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[Formula: see text]inadequate effort on neuropsychological evaluation is associated with increased healthcare utilization. | Patients who exert inadequate effort on neuropsychological examination might not receive accurate diagnoses and recommendations, and might not cooperate fully with other aspects of healthcare. This study examined whether inadequate effort is associated with increased healthcare utilization. Of 355 patients seen for rou... | ['Adult', 'Aged', 'Costs and Cost Analysis', 'Diagnostic and Statistical Manual of Mental Disorders', 'Emergency Service, Hospital', 'Female', 'Health Resources', 'Hospitalization', 'Hospitals, Psychiatric', 'Humans', 'Male', 'Mental Disorders', 'Middle Aged', 'Neuropsychological Tests', 'Outpatients', 'Patient Complia... | 24,931,877 | [['M01.060.116'], ['M01.060.116.100'], ['N03.219.151'], ['L01.453.245.945.200'], ['N02.278.216.500.968.336', 'N02.421.297.195', 'N04.452.442.452.422.336'], ['N03.349.340', 'N05.300.420'], ['E02.760.400', 'N02.421.585.400'], ['N02.278.421.556.508'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F03'], ['M01.060.116... | ['Named Groups [M]', 'Health Care [N]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
A functional null mutation of SCN1B in a patient with Dravet syndrome. | Dravet syndrome (also called severe myoclonic epilepsy of infancy) is one of the most severe forms of childhood epilepsy. Most patients have heterozygous mutations in SCN1A, encoding voltage-gated sodium channel Na(v)1.1 alpha subunits. Sodium channels are modulated by beta1 subunits, encoded by SCN1B, a gene also link... | ['Animals', 'Arginine', 'Biophysics', 'Cell Line, Transformed', 'Cysteine', 'DNA Mutational Analysis', 'Disease Models, Animal', 'Electric Stimulation', 'Epilepsies, Myoclonic', 'Female', 'Green Fluorescent Proteins', 'Hippocampus', 'Humans', 'In Vitro Techniques', 'Infant', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Mice,... | 19,710,327 | [['B01.050'], ['D12.125.068.050', 'D12.125.095.104', 'D12.125.142.087'], ['H01.158.344', 'H01.671.100'], ['A11.251.210.172'], ['D02.886.030.230', 'D02.886.489.155', 'D12.125.154.299', 'D12.125.166.230'], ['E05.393.760.700.300'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['E05.723.402'], ['C10.228.140.490.375.130',... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Increased release of interleukin-1 beta, interleukin-6, and tumor necrosis factor-alpha by bronchoalveolar cells lavaged from involved sites in pulmonary tuberculosis. | Mycobacterium tuberculosis and its components have been shown to stimulate mononuclear phagocytes in vitro to release interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6). Animal models of tuberculosis (TB) also demonstrate the presence of cytokines in granulomas. We hypothe... | ['AIDS-Related Opportunistic Infections', 'Adult', 'Blotting, Northern', 'Bronchoalveolar Lavage Fluid', 'Cell Count', 'Cells, Cultured', 'Enzyme-Linked Immunosorbent Assay', 'Female', 'Humans', 'Interleukin-1', 'Interleukin-6', 'Lymphocytes', 'Macrophages', 'Male', 'Neutrophils', 'RNA, Messenger', 'Tuberculosis, Pulmo... | 8,564,135 | [['C01.221.250.875.100', 'C01.597.050', 'C01.610.684.050', 'C01.925.597.050', 'C01.925.782.815.616.400.100', 'C20.673.480.100'], ['M01.060.116'], ['E05.196.401.095', 'E05.301.300.074', 'E05.601.100'], ['E05.927.100.500'], ['E01.370.225.500.195', 'E05.200.500.195', 'E05.242.195', 'G04.140'], ['A11.251'], ['E05.478.566.3... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The effect of a single oral dose of azithromycin on chlamydial salpingitis in mice. | Progesterone-treated C3H mice were inoculated under the ovarian bursa with a human Chlamydia trachomatis strain, serovar E, and treated variously from one week before inoculation to two weeks afterwards with a single oral dose of azithromycin. At autopsy, all 27 control mice, not given azithromycin, had histological ev... | ['Animals', 'Azithromycin', 'Chlamydia Infections', 'Chlamydia trachomatis', 'Erythromycin', 'Female', 'Mice', 'Mice, Inbred C3H', 'Salpingitis'] | 1,663,931 | [['B01.050'], ['D02.540.576.500.992.050'], ['C01.150.252.400.210.125', 'C01.150.252.734.301', 'C01.221.812.281.301', 'C01.778.281.301', 'C12.294.668.281.301', 'C13.351.500.711.281.301'], ['B03.440.190.190.190.750'], ['D02.540.576.500.992'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.388', 'B... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Successful treatment of a congenital pulmonic valvular stenosis in a snow leopard (Uncia uncia) by percutaneous balloon valvuloplasty. | A 3-yr-old intact female snow leopard (Uncia uncia) was evaluated for progressive apathy, lethargy, and decreased appetite. Cardiac auscultation revealed a left basal grade IV/VI systolic ejection murmur, and an echocardiogram confirmed a severe pulmonic valvular stenosis (pressure gradient of 98 mm Hg). The lesion was... | ['Animals', 'Catheterization', 'Felidae', 'Female', 'Pulmonary Valve', 'Pulmonary Valve Stenosis'] | 21,370,661 | [['B01.050'], ['E02.148', 'E05.157'], ['B01.050.150.900.649.313.750.377.750'], ['A07.541.510.738'], ['C14.280.484.716', 'C14.280.955.750']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Molecular cloning and sequence analysis of human dipeptidyl peptidase IV, a serine proteinase on the cell surface. | The cDNA coding for the human dipeptidyl peptidase IV (DPPIV) has been isolated and sequenced. The nucleotide sequence (3465 bp) of the cDNA contains an open reading frame encoding a polypeptide comprising 766 amino acids, one residue less than those of rat DPPIV. The predicted amino acid sequence exhibits 84.9% identi... | ['Amino Acid Sequence', 'Base Sequence', 'Cloning, Molecular', 'Dipeptidyl Peptidase 4', 'Dipeptidyl-Peptidases and Tripeptidyl-Peptidases', 'Humans', 'Membrane Glycoproteins', 'Molecular Sequence Data'] | 1,352,704 | [['G02.111.570.060', 'L01.453.245.667.060'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.393.220'], ['D08.811.277.656.350.350.126', 'D08.811.277.656.959.250', 'D23.050.301.264.894.160', 'D23.101.100.894.160'], ['D08.811.277.656.350.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.3... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Effect of early gestational undernutrition on angiogenic factor expression and vascularity in the bovine placentome. | The effect of early gestation maternal undernutrition followed by realimentation on placentomal vascular growth and angiogenic factor expression was determined in multiparous beef cows bred to the same bull. Cows gestating only female fetuses (n = 30) were fed in equal numbers to meet the NRC requirements (control) or ... | ['Angiogenesis Inducing Agents', 'Animal Nutritional Physiological Phenomena', 'Animals', 'Cattle', 'Female', 'Food Deprivation', 'Gestational Age', 'Maternal Nutritional Physiological Phenomena', 'Neovascularization, Physiologic', 'Organ Size', 'Placenta', 'Placental Circulation', 'Pregnancy', 'Receptor Protein-Tyrosi... | 17,565,057 | [['D27.505.696.377.077.077'], ['G07.203.650.161'], ['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['F01.658.433'], ['G07.345.500.325.235.968', 'G08.686.320'], ['G07.203.650.566'], ['G09.330.630'], ['E01.370.600.115.100.660', 'E05.041.124.715', 'G07.100.100.660', 'G07.345.249.690'], ['A16.710'], ['G09.330.100.749... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Airway obstruction by a ball. | A toddler died as the result of choking on a toy ball that occluded his upper airway. The size of this toy was within the federal safety standards for use by children under the age of three years. Though it has been recognized since 1987 that the minimum safe diameter set by the Federal Hazardous Substances Act may be ... | ['Airway Obstruction', 'Child, Preschool', 'Fatal Outcome', 'Forensic Medicine', 'Humans', 'Inhalation', 'Male', 'Play and Playthings'] | 10,486,963 | [['C08.618.846.185'], ['M01.060.406.448'], ['E05.318.308.985.550.325', 'N01.224.935.698.201', 'N06.850.505.400.975.550.325', 'N06.850.520.308.985.550.325'], ['H02.403.330', 'I01.198.780.937'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G09.772.705.700.390'], ['I03.450.642.693']] | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 |
Ciprofloxacin as prophylaxis for urinary tract infection: prospective, randomized, cross-over, placebo controlled study in patients with spinal cord lesion. | To evaluate the efficacy of low-dose long-term treatment with ciprofloxacin in the prevention of recurrent urinary tract infections in patients with spinal cord lesions and neurogenic bladder dysfunction, a prospective, randomized, cross-over, placebo-controlled study was performed. The study period was 12 months long,... | ['Adult', 'Aged', 'Alanine Transaminase', 'Ciprofloxacin', 'Double-Blind Method', 'Feces', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Middle Aged', 'Prospective Studies', 'Spinal Cord Injuries', 'Urinary Bladder, Neurogenic', 'Urinary Tract Infections', 'Urine'] | 8,254,783 | [['M01.060.116'], ['M01.060.116.100'], ['D08.811.913.477.700.100'], ['D03.633.100.810.835.322.186'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['A12.459'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Genetic analysis of pod dehiscence in pea (Pisum sativum L.). | The inheritance of the dehiscent pod character was investigated in two recombinant inbred populations using a simplified correlation analysis. The approach identified three regions on the pea genome that affect the expression of pod dehiscence. The region on linkage group III corresponded to the expected position of Dp... | ['Chromosome Mapping', 'Crosses, Genetic', 'Genetic Linkage', 'Genetic Markers', 'Genome, Plant', 'Peas', 'Quantitative Trait Loci'] | 12,378,224 | [['E05.393.183'], ['E05.393.281'], ['G05.348'], ['D23.101.387', 'G05.695.450'], ['G05.360.340.365'], ['B01.650.940.800.575.912.250.401.630'], ['G05.360.340.024.380.937']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The development of the 'Quality-of-life for Respiratory Illness Questionnaire (QOL-RIQ)': a disease-specific quality-of-life questionnaire for patients with mild to moderate chronic non-specific lung disease. | Chronic non-specific lung disease (CNSLD) encompasses asthma as well as chronic obstructive pulmonary disease (COPD). Recently in health care, there has been increasing awareness in the functional, psychological and social aspects of the health of patients; their quality of life (QOL). Quality-of-life research addressi... | ['Adolescent', 'Adult', 'Aged', 'Asthma', 'Bronchitis', 'Evaluation Studies as Topic', 'Humans', 'Lung', 'Lung Diseases, Obstructive', 'Middle Aged', 'Pulmonary Emphysema', 'Quality of Life', 'Regression Analysis', 'Severity of Illness Index', 'Surveys and Questionnaires'] | 9,176,649 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['C01.748.099', 'C08.127.446', 'C08.381.495.146', 'C08.730.099'], ['E05.337', 'N05.715.360.335'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A04.411'], ['C08.381.495'], ['M01.060.116... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
The role of 1% sodium hyaluronate in anterior capsulotomy with the neodymium:YAG laser in patients with diseased cornea. | Patients with preexisting corneal pathology who needed cataract extraction had an anterior capsulotomy performed with a Q-switched Nd:YAG laser (LASAG Microruptor II). Thirty-two patients had no sodium hyaluronate (Healon) and 36 patients had Healon injected into the anterior chamber prior to the laser surgery. The non... | ['Cataract', 'Cataract Extraction', 'Corneal Diseases', 'Drug Evaluation', 'Humans', 'Hyaluronic Acid', 'Intraoperative Period', 'Laser Therapy', 'Lens Capsule, Crystalline', 'Lens, Crystalline', 'Osmolar Concentration'] | 3,783,473 | [['C11.510.245'], ['E04.540.825.249'], ['C11.204'], ['E05.290.625', 'E05.337.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D09.698.373.475'], ['E04.614.374', 'N02.421.585.753.374'], ['E02.594', 'E04.014.520'], ['A09.371.060.500.155'], ['A09.371.060.500'], ['G02.640']] | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Expression of conserved mucin domains by epithelial tissues in various mammalian species. | UNLABELLED: Mucins are related to infectious and non-infectious diseases in Veterinary and Human Medicine. MUC1 mucin is a transmembrane glycoprotein expressed on the apical surface of human epithelia while MUC5AC is the predominant secreted mucin expressed in human gastric epithelium and goblet cells of lung and eyes.... | ['Animals', 'Antibodies, Monoclonal', 'Blotting, Western', 'Epithelium', 'Humans', 'Immunohistochemistry', 'Mammals', 'Mucin 5AC', 'Mucin-1', 'Protein Structure, Tertiary'] | 18,582,913 | [['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['A10.272'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
[Clinical evaluation of combined spinal-epidural anesthesia by needle-through-needle approach in 485 surgical cases]. | We analyzed retrospectively the technical and clinical consequences of combined spinal-epidural anesthesia by needle-through-needle approach over the last two years. A Tuohy-type 18-gauge epidural needle (Perican; B. Braun Co.) and long pencil-pointed 27-gauge spinal needle (Whitacre; Becton-Dikinson Co.) were selected... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Anesthesia, Epidural', 'Anesthesia, Spinal', 'Buprenorphine', 'Child', 'Female', 'Humans', 'Male', 'Mepivacaine', 'Middle Aged', 'Needles', 'Retrospective Studies', 'Tetracaine'] | 11,025,950 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E03.155.086.131'], ['E03.155.086.331'], ['D03.132.577.249.150', 'D03.605.497.150', 'D03.633.400.686.150', 'D04.615.723.795.150'], ['M01.060.406'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.383.621.450'], ['M01.060.116.630'],... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The cataract national data set electronic multi-centre audit of 55,567 operations: case-mix adjusted surgeon's outcomes for posterior capsule rupture. | AIMS: To develop a methodology for case-mix adjustment of surgical outcomes for individual cataract surgeons using electronically collected multi-centre data conforming to the cataract national data set (CND).METHODS: Routinely collected anonymised data were remotely extracted from electronic patient record (EPR) syste... | ['Cataract Extraction', 'Clinical Competence', 'Electronic Health Records', 'England', 'Humans', 'Intraoperative Complications', 'Medical Audit', 'Ophthalmology', 'Outcome Assessment, Health Care', 'Posterior Capsular Rupture, Ocular', 'Quality of Health Care', 'Risk Adjustment'] | 21,546,922 | [['E04.540.825.249'], ['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['E05.318.308.940.968.625.500', 'N04.452.859.564.650.125', 'N05.715.360.300.715.500.530.250', 'N06.850.520.308.940.968.625.250'], ['Z01.542.363.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.505'], ['N04.761.700.250.500', 'N05.7... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Geographicals [Z]', 'Organisms [B]', 'Diseases [C]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 |
[Design and manufacture of a utility artificial hand for a burned child by three-dimensional printing technology and its application]. | In May 2015, a child with absence of most of the five fingers with scar formation after healing of a left hand burn wound hospitalized in our burn ward. According to the free online design program for making artificial limbs using three-dimensional printing technology on the internet, a utility artificial hand, most of... | ['Artificial Limbs', 'Burns', 'Child', 'Hand', 'Humans', 'Printing, Three-Dimensional', 'Prosthesis Design'] | 30,157,556 | [['E07.695.050', 'E07.858.082.050', 'E07.858.442.050'], ['C26.200'], ['M01.060.406'], ['A01.378.800.667'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['J01.897.564', 'L01.224.108.150.500', 'L01.296.110.150.500'], ['E05.320.550', 'E07.695.680']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 |
'I just can't help myself': effects of food-cue exposure in overweight and lean individuals. | OBJECTIVE: Even brief exposure to the sight and smell of food has been shown to increase reported appetite, initiate 'cephalic phase responses,' and increase planned and actual consumption. This experiment tested the hypothesis that overweight individuals are especially sensitive to these established effects of food-cu... | ['Adult', 'Appetite', 'Cues', 'Feeding Behavior', 'Female', 'Food', 'Humans', 'Impulsive Behavior', 'Overweight', 'Prospective Studies', 'Salivation', 'Satiation', 'Smell'] | 20,548,302 | [['M01.060.116'], ['F02.830.071', 'G07.203.650.390.070', 'G10.261.390.070'], ['F02.463.425.234'], ['F01.145.113.547', 'F01.145.407', 'G07.203.650.353'], ['G07.203.300', 'J02.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.527'], ['C23.888.144.699', 'E01.370.600.115.100.160.120.699', 'G07.100.100.160.1... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Ultrastructural and biochemical modifications of rabbit arteries induced by immunization with soluble elastin peptides. | Immunization of rabbits with soluble elastin peptides (kappa 1-elastin) in complete Freund's adjuvant resulted in morphological and biochemical modifications in aorta and in lung arterioles. The elastic fibers of both tissues appeared fragmented at the light microscopical and ultrastructural levels. The presence of IgG... | ['Animals', 'Antibodies', 'Aorta', 'Arterioles', 'Elastin', 'Immunization', 'Lung', 'Male', 'Pancreatic Elastase', 'Rabbits'] | 6,566,612 | [['B01.050'], ['D12.776.124.486.485.114', 'D12.776.124.790.651.114', 'D12.776.377.715.548.114'], ['A07.015.114.056'], ['A07.015.114.060', 'A07.015.461.080'], ['D05.750.078.421', 'D12.776.860.300.350'], ['E02.095.465.425.400', 'E05.478.550', 'N02.421.726.758.310', 'N06.850.780.200.425', 'N06.850.780.680.310'], ['A04.411... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Temporary abdominal closure: long-term outcomes. | BACKGROUND: Temporary abdominal closure (TAC) is an invaluable tool in the armamentarium of surgeons caring for critically ill and injured patients. The objective of this study was to determine the incidence of abdominal wall hernias and intestinal obstructions in patients who underwent TAC.METHODS: A retrospective rev... | ['Abdominal Injuries', 'Abdominal Wound Closure Techniques', 'Adult', 'Aged', 'Aged, 80 and over', 'Critical Illness', 'Female', 'Follow-Up Studies', 'Hernia, Abdominal', 'Humans', 'Incidence', 'Intestinal Obstruction', 'Male', 'Middle Aged', 'Postoperative Complications', 'Retrospective Studies', 'Survival Rate', 'Tim... | 21,610,384 | [['C26.017'], ['E04.987.100'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C23.550.291.625'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['C23.300.707.374'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Resonance energy transfer measurements between substrate binding sites within the large (Klenow) fragment of Escherichia coli DNA polymerase I. | Resonance energy transfer was used to determine separation distances between fluorescent derivatives of substrates for Klenow fragment and a unique sulfhydryl, cysteine 907, on the enzyme. Fluorescent derivatives of duplex DNA, deoxynucleotide triphosphates (dNTP), and deoxynucleotide monophosphates (dNMP), modified wi... | ['Base Sequence', 'Binding Sites', 'DNA Polymerase I', 'DNA, Bacterial', 'Energy Transfer', 'Escherichia coli', 'Fluorescence', 'Phosphates', 'Protein Conformation', 'Quantum Theory', 'Substrate Specificity', 'Sulfhydryl Compounds'] | 2,692,712 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G02.111.570.120'], ['D08.811.913.696.445.308.300.225'], ['D13.444.308.212'], ['G01.154.240', 'G02.111.255', 'G02.216'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['G01.358.500.505.650.665.500', 'G01.590.540.665.500'], ['D01.029.260.700.675.374'... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Per-Oral Endoscopic Myotomy Versus Laparoscopic Heller Myotomy for Achalasia: A Meta-Analysis of Nonrandomized Comparative Studies. | We aimed to assess the short-term outcomes of per-oral endoscopic myotomy (POEM) compared with laparoscopic Heller myotomy (LHM) for achalasia through a meta-analysis of nonrandomized comparative studies.We searched PubMed, Embase, Medline, Cochrane Library, and Google Scholar for studies that compared POEM and LHM for... | ['Cardia', 'Esophageal Achalasia', 'Esophageal Sphincter, Lower', 'Esophagoscopy', 'Humans', 'Laparoscopy', 'Models, Statistical', 'Natural Orifice Endoscopic Surgery', 'Treatment Outcome'] | 26,871,816 | [['A03.556.875.875.163'], ['C06.405.117.119.500.432'], ['A02.633.570.210', 'A03.556.875.500.414.350', 'A03.556.875.875.330.350'], ['E01.370.372.250.250.275', 'E01.370.388.250.250.250.260', 'E04.210.240.250.260', 'E04.502.250.250.250.260'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.388.250.520', 'E04.50... | ['Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Is an integral nutritional approach to eating disorders feasible in primary care? | Patients with eating disorders (ED) show alterations in both their behaviour and their intake of food, frequently presenting nutritional and somatic affectations. Besides the classical forms such as anorexia or bulimia nervosa, there has recently been an increase in atypical or incomplete forms of ED, such as binge eat... | ['Energy Intake', 'Feeding Behavior', 'Feeding and Eating Disorders', 'Health Education', 'Humans', 'Nutritional Physiological Phenomena', "Physician's Role", 'Physician-Patient Relations', 'Physicians, Family'] | 16,923,258 | [['G07.203.650.240.340'], ['F01.145.113.547', 'F01.145.407', 'G07.203.650.353'], ['F03.400'], ['I02.233.332', 'N02.421.726.407'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G07.203.650'], ['F01.829.316.616.625.600'], ['F01.829.401.650.675', 'N05.300.660.625'], ['M01.526.485.810.770', 'N02.360.810.770']] | ['Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Effects of population dispersal on regional signaling networks: An example from northern Iroquoia. | The dispersal of Iroquoian groups from St. Lawrence River valley during the 15th and 16th centuries A.D. has been a source of archaeological inquiry for decades. Social network analysis presented here indicates that sites from Jefferson County, New York at the head of the St. Lawrence River controlled interactions with... | ['Archaeology', 'Geography', 'History, 15th Century', 'History, 16th Century', 'History, 17th Century', 'History, Medieval', 'Humans', 'Models, Theoretical', 'New York', 'Ontario', 'Population Dynamics', 'Quebec', 'Social Networking'] | 28,808,682 | [['I01.076.201.208'], ['H01.277.500'], ['K01.400.475.500'], ['K01.400.475.750'], ['K01.400.504.750'], ['K01.400.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599'], ['Z01.107.567.875.075.437', 'Z01.107.567.875.350.530', 'Z01.107.567.875.500.530'], ['Z01.107.567.176.639'], ['I01.240.600', 'N01.224.625', ... | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Disciplines and Occupations [H]', 'Humanities [K]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Health Care [N]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 |
Dynamic ABCG2 expression in human embryonic stem cells provides the basis for stress response. | ABCG2 is a plasma membrane multidrug transporter with an established role in the cancer drug-resistance phenotype. This protein is expressed in a variety of tissues, including several types of stem cell. Although ABCG2 is not essential for life, knock-out mice were found to be hypersensitive to xenobiotics and had redu... | ['ATP Binding Cassette Transporter, Subfamily G, Member 2', 'ATP-Binding Cassette Transporters', 'Cell Line', 'Embryonic Stem Cells', 'Gene Expression Regulation', 'Humans', 'Neoplasm Proteins', 'Oxidative Stress', 'Protein Transport', 'Ultraviolet Rays', 'Xenobiotics'] | 22,851,001 | [['D12.776.157.530.100.228.500', 'D12.776.395.550.020.457.500', 'D12.776.543.550.192.457.500', 'D12.776.543.585.100.228.500'], ['D12.776.157.530.100', 'D12.776.395.550.020', 'D12.776.543.550.192', 'D12.776.543.585.100'], ['A11.251.210'], ['A11.872.700.250'], ['G05.308'], ['B01.050.150.900.649.313.988.400.112.400.400'],... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Mercury in hair as an indicator of total body burden. | Hair is known to concentrate mercury, and in general the concentration of mercury in hair is proportional to and many times higher than its concentration in the blood. The variation of the mercury concentration in human head hair was used to follow the history of poisoning in people who ingested grain treated with meth... | ['Adolescent', 'Adult', 'Aged', 'Child', 'Female', 'Hair', 'Half-Life', 'Humans', 'Kinetics', 'Male', 'Mercury', 'Mercury Poisoning', 'Methylmercury Compounds', 'Middle Aged'] | 1,086,158 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.406'], ['A17.360'], ['G01.910.405'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.374.661', 'G02.111.490'], ['D01.268.556.504', 'D01.268.956.437', 'D01.552.544.504'], ['C25.723.522.875'], ['D02.691.750.100.738'], ['M01.060.116.630']] | ['Named Groups [M]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Negative regulation of TSC1-TSC2 by mammalian D-type cyclins. | The metazoan cell cycle is driven by the timely and composite activities of cyclin-dependent kinases (CDKs). Among these, cyclin D- and cyclin E-dependent kinases phosphorylate the pRb family proteins during G(1) phase of the cell cycle and thereby advance cells beyond the restriction point. Increasing evidence suggest... | ['Adaptor Proteins, Signal Transducing', 'Bone Neoplasms', 'Carrier Proteins', 'Cell Cycle Proteins', 'Cells, Cultured', 'Cyclin D1', 'Cyclin-Dependent Kinase 4', 'Cyclin-Dependent Kinase 6', 'Cyclin-Dependent Kinase Inhibitor p16', 'G1 Phase', 'Gene Expression Regulation', 'Humans', 'Kidney', 'Osteosarcoma', 'Phosphop... | 16,357,142 | [['D12.644.360.024', 'D12.776.157.057', 'D12.776.476.024'], ['C04.588.149', 'C05.116.231'], ['D12.776.157'], ['D12.776.167'], ['A11.251'], ['D12.644.360.262.150.100', 'D12.776.167.218.150.100', 'D12.776.476.262.150.100', 'D12.776.624.664.700.100'], ['D08.811.913.696.620.682.700.646.500.875', 'D12.644.360.250.451', 'D12... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Preliminary report: laboratory-induced stain removal as assessed by environmental scanning electron microscopy. | Environmental scanning electron microscopy (ESEM) was employed to observe stain removal during brushing with Arm & Hammer Dental Care and Crest Regular Toothpaste. ESEM allows serial examinations of the same sample, and does not require a destructive preparative process. Three extracted molars were cleaned, placed into... | ['Chlorhexidine', 'Humans', 'Hydrogen Peroxide', 'Microscopy, Electron, Scanning', 'Molar', 'Silicic Acid', 'Silicon Dioxide', 'Sodium Bicarbonate', 'Sodium Fluoride', 'Tooth Discoloration', 'Toothbrushing', 'Toothpastes'] | 10,518,864 | [['D02.078.370.141.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.248.497.158.685.750.424', 'D01.339.431.374.424', 'D01.650.550.750.400', 'D02.389.338.253'], ['E01.370.350.515.402.541', 'E05.595.402.541'], ['A14.549.167.860.525'], ['D01.029.260.863', 'D01.837.725.700'], ['D01.578.750', 'D01.650.550.825',... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Use of contraceptive depot medroxyprogesterone acetate is associated with impaired cervicovaginal mucosal integrity. | BACKGROUND: Injectable depot medroxyprogesterone acetate (DMPA) is one of the most popular contraception methods in areas of high HIV seroprevalence. Evidence is accumulating that use of DMPA might be associated with an increased risk of HIV-1 acquisition by women; however, mechanisms of this association are not comple... | ['Adult', 'Cervix Uteri', 'Contraceptive Agents, Female', 'Female', 'HIV Infections', 'HIV-1', 'Humans', 'Immunity, Mucosal', 'Medroxyprogesterone Acetate', 'Middle Aged', 'Mucous Membrane', 'Prospective Studies', 'Seroepidemiologic Studies', 'Vagina'] | 30,222,141 | [['M01.060.116'], ['A05.360.319.679.256'], ['D27.505.696.875.360.276', 'D27.505.954.705.360.276'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['B04.820.650.589.650.350.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G12.450.573']... | ['Named Groups [M]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Determination of methadone, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine and alprazolam in human plasma by liquid chromatography-electrospray ionization mass spectrometry. | A fast liquid chromatographic assay with mass spectrometric detection (LC/MS) has been developed and validated for the simultaneous determination of methadone (MT), its primary metabolite, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) and alprazolam, in human plasma. The extraction procedure was performed wi... | ['Alprazolam', 'Calibration', 'Chromatography, Liquid', 'Humans', 'Methadone', 'Pyrrolidines', 'Reproducibility of Results', 'Sensitivity and Specificity', 'Spectrometry, Mass, Electrospray Ionization'] | 16,517,229 | [['D03.633.100.079.080.030'], ['E05.978.155'], ['E05.196.181.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.522.675'], ['D03.383.773'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700', 'N05.715.360.7... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Effect of unsaturated menthol analogues on the in vitro penetration of 5-fluorouracil through rat skin. | To explore the structure-activity relationship for terpenes as transdermal penetration enhancers, unsaturated menthol analogues were synthesized in our study, including p-menth-1-en-3-ol (Compd 1), p-menth-4-en-3-ol (Compd 2), p-menth-4(8)-en-3-ol (Compd 3) and p-menth-8-en-3-ol (Compd 4). Their enhancing activity on t... | ['Administration, Cutaneous', 'Animals', 'Antimetabolites, Antineoplastic', 'Binding Sites', 'Chromatography, High Pressure Liquid', 'Drug Carriers', 'Fluorouracil', 'Hydrophobic and Hydrophilic Interactions', 'In Vitro Techniques', 'Lipids', 'Male', 'Menthol', 'Models, Molecular', 'Molecular Structure', 'Rats', 'Rats,... | 23,333,756 | [['E02.319.267.120.060'], ['B01.050'], ['D27.505.519.186.144', 'D27.505.954.248.144', 'D27.888.569.042.030'], ['G02.111.570.120'], ['E05.196.181.400.300'], ['D26.255.260', 'E02.319.300.380'], ['D03.383.742.698.875.404'], ['G02.409'], ['E05.481'], ['D10'], ['D02.033.415.510.500.605', 'D02.455.426.392.368.367.211.750', '... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
An in vivo model for evaluation of the postantibiotic effect. | A new experimental model to evaluate the postantibiotic effect (PAE) in vivo was developed using subcutaneously implanted tissue cages in rabbits with normal host defence mechanisms. The rabbits received benzylpenicillin i.v. in a dose giving a free penicillin concentration of 10 X MIC in the tissue cage fluid (TCF). A... | ['Animals', 'Anti-Bacterial Agents', 'Bacteria', 'Female', 'Microbial Sensitivity Tests', 'Models, Biological', 'Penicillin G', 'Prostheses and Implants', 'Protein Binding', 'Rabbits', 'Streptococcus pyogenes'] | 3,283,924 | [['B01.050'], ['D27.505.954.122.085'], ['B03'], ['E01.370.225.875.595', 'E05.200.875.595', 'E05.337.550.400'], ['E05.599.395'], ['D02.065.589.099.750.750', 'D02.886.108.750.750', 'D03.633.100.300.750.750'], ['E07.695'], ['G02.111.679', 'G03.808'], ['B01.050.150.900.649.313.968.700'], ['B03.353.750.737.872.575', 'B03.51... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Prognostic significance of constitutive phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase phosphorylation in acute myeloid leukemia. | Acute myeloid leukemia (AML) is a malignant hematopoietic disease with poor clinical course and outcome. There is a constant need for new prognostic factors that could facilitate patient risk stratification. The aim of our research was to determine the phosphorylation levels of phosphatidylinositol 3-kinase (PI3K)/Akt ... | ['ATP Binding Cassette Transporter, Subfamily B, Member 1', 'Antineoplastic Combined Chemotherapy Protocols', 'Biomarkers', 'Female', 'Gene Expression', 'Humans', 'Immunophenotyping', 'Kaplan-Meier Estimate', 'Leukemia, Myeloid, Acute', 'Male', 'Mitogen-Activated Protein Kinases', 'Phosphatidylinositol 3-Kinases', 'Pho... | 25,426,669 | [['D12.776.157.530.100.075.063', 'D12.776.157.530.450.074.500.500.250.125', 'D12.776.395.550.020.400.153', 'D12.776.543.550.192.400.153', 'D12.776.543.585.100.200.125', 'D12.776.543.585.450.074.500.500.250.125'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['D23.101'], ['G05.297'], ['B01.050.150.900.649.... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
A mixed-methods survey to explore views of staff and patients from mental health wards prior to introduction of a digital early warning system for physical deterioration. | WHAT IS KNOWN ON THE SUBJECT?: The potential benefits of introducing technological innovation into all types of health services are recognized internationally. There are few studies exploring the use of technology in inpatient mental health settings, or the views of staff and patients regarding such developments. "Earl... | ['Adult', 'Attitude of Health Personnel', 'Computers, Handheld', 'Hospital Information Systems', 'Humans', 'Inpatients', 'Observation', 'Patient Preference', 'Psychiatric Department, Hospital', 'Surveys and Questionnaires'] | 30,742,343 | [['M01.060.116'], ['F01.100.050', 'N05.300.100'], ['L01.224.230.260.550.500'], ['N04.452.442.452.452', 'N04.452.515.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.643.470'], ['E05.581.249'], ['F01.100.150.750.625.500', 'F01.145.488.887.625.500', 'N04.452.822.700.500', 'N05.300.150.800.625.500'], ['N02.27... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
A very limited number of keywords (main patterns) describes all sequences of the human variable heavy (VH) and kappa (Vkappa) domains. | Sequences of the variable heavy (VH) and kappa (Vkappa) domains of Ig structures were divided into 21 fragments that correspond to strands, loops, or parts of these structural units of the variable domains. Amino acid sequences of fragments (termed "words") were collected from the 1,172 human heavy and 668 human kappa ... | ['Computer Simulation', 'Humans', 'Immunoglobulin Heavy Chains', 'Immunoglobulin Variable Region', 'Immunoglobulin kappa-Chains', 'Sequence Analysis', 'Statistics as Topic'] | 9,356,489 | [['L01.224.160'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.124.486.485.705.500', 'D12.776.124.790.651.705.500', 'D12.776.377.715.548.705.500'], ['D12.644.541.500.650.500', 'D12.776.124.486.485.680.650.500', 'D12.776.124.486.485.797', 'D12.776.124.790.651.680.650.500', 'D12.776.124.790.651.797', 'D12.7... | ['Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Fine mapping for double podding gene in chickpea. | KEY MESSAGE: For the first time, fine mapping for sfl locus was carried out using a battery of new STMS and SNP markers. The target region was delimited to 92.6 Kb where seven annotated genes were found that could be candidate genes for the simple/double podding trait in chickpea. Four recombinant inbred populations (R... | ['Cicer', 'Crosses, Genetic', 'Genes, Plant', 'Genetic Linkage', 'Genetic Markers', 'Microsatellite Repeats', 'Phenotype', 'Physical Chromosome Mapping', 'Polymorphism, Single Nucleotide', 'Sequence Tagged Sites'] | 26,433,827 | [['B01.650.940.800.575.912.250.401.150'], ['E05.393.281'], ['G05.360.340.024.340.393', 'G05.360.340.365.500'], ['G05.348'], ['D23.101.387', 'G05.695.450'], ['G02.111.570.080.708.800.500', 'G05.360.080.708.800.500', 'G05.360.340.024.850.500'], ['G05.695'], ['E05.393.183.620'], ['G05.365.795.598'], ['G05.360.340.024.810'... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Predicting the chances of a live birth after one or more complete cycles of in vitro fertilisation: population based study of linked cycle data from 113 873 women. | OBJECTIVE: To develop a prediction model to estimate the chances of a live birth over multiple complete cycles of in vitro fertilisation (IVF) based on a couple's specific characteristics and treatment information.DESIGN: Population based cohort study.SETTING: All licensed IVF clinics in the UK. National data from t... | ['Adult', 'Age Factors', 'Birth Rate', 'Female', 'Fertilization in Vitro', 'Humans', 'Live Birth', 'Predictive Value of Tests', 'Pregnancy', 'Pregnancy Rate', 'Probability', 'Time Factors', 'United Kingdom'] | 27,852,632 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['E05.318.308.985.775.500', 'N01.224.935.849.500', 'N06.850.505.400.975.775.500', 'N06.850.520.308.985.775.500'], ['E02.875.800.750', 'E05.820.800.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G08.686.784.769.496.249'], ['E05.318.370.800.650', 'N05.7... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Effects of ascorbic acid and EDTA on vascular concentration-response to catecholamines. | Concentration-response curves are often used as indicators of vascular reactivity and receptor sensitivity. Some investigators use ethylenediaminetetraacetate (EDTA) or ascorbic acid (ASC) to prevent catecholamine oxidation but many others do not. This difference may affect estimates of reactivity. We tested the effect... | ['Animals', 'Aorta, Thoracic', 'Ascorbic Acid', 'Cricetinae', 'Dose-Response Relationship, Drug', 'Edetic Acid', 'Epinephrine', 'Male', 'Mesocricetus', 'Muscle, Smooth, Vascular', 'Muscles', 'Norepinephrine', 'Oxidation-Reduction', 'Rats', 'Rats, Inbred Strains', 'Vasoconstriction'] | 6,412,040 | [['B01.050'], ['A07.015.114.056.372'], ['D02.241.081.844.107', 'D02.241.511.902.107', 'D09.811.100'], ['B01.050.150.900.649.313.992.635.075.250'], ['G07.690.773.875', 'G07.690.936.500'], ['D02.092.782.258.368.250', 'D02.241.081.018.253'], ['D02.033.100.291.310', 'D02.092.063.291.310', 'D02.092.211.215.454', 'D02.092.31... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Potentiation of twitch contraction in guinea pig ureter by sodium vanadate. | The effect of sodium vanadate on action potential and twitch contraction of guinea pig ureter was studied and compared with that of ouabain, elevated K+, low temperature, and a Ca agonist (BAY K 8644), which can be expected to exert certain comparative effects. Sodium vanadate markedly potentiated twitch contraction. P... | ['Action Potentials', 'Animals', 'Calcium', 'Cytosol', 'Guinea Pigs', 'Muscle Contraction', 'Muscle, Smooth', 'Ouabain', 'Potassium', 'Sodium', 'Temperature', 'Ureter', 'Vanadates'] | 1,443,105 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['A11.284.430.214.200', 'A11.284.430.429.200', 'A11.284.835.450.200'], ['B01.050.150.900.649.313.992.550'], ['G11.427.494'], ['A02.633.570', 'A10.690.467'], ['D04.210.500.155.580.130.750.600', 'D0... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
DNA cytofluorometry in micro-dissected paraffin embedded breast tissue: description of a method. | DNA microfluorometry on smears obtained from paraffin embedded tissue has been shown to be a distinctive possibility. In this paper a simple method for the detachment of cells from mammary ducts and ductules is described. Areas of interest were selected in conventional slides stained with Haematoxylin and Eosin. The co... | ['Breast Neoplasms', 'Carcinoma', 'DNA, Neoplasm', 'Flow Cytometry', 'Humans', 'Microtomy', 'Paraffin'] | 3,442,555 | [['C04.588.180', 'C17.800.090.500'], ['C04.557.470.200'], ['D13.444.308.425'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.200.500.386.350', 'E05.242.363.342', 'E05.242.386.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.620... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Spatial projection as a preprocessing step for EEG source reconstruction using spatiotemporal Kalman filtering. | The reconstruction of brain sources from non-invasive electroencephalography (EEG) or magnetoencephalography (MEG) via source imaging can be distorted by information redundancy in case of high-resolution recordings. Dimensionality reduction approaches such as spatial projection may be used to alleviate this problem. In... | ['Algorithms', 'Brain', 'Brain Mapping', 'Electroencephalography', 'Magnetoencephalography'] | 29,060,336 | [['G17.035', 'L01.224.050'], ['A08.186.211'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['E01.370.376.300', 'E01.370.405.245'], ['E01.370.376.500', 'E01.370.405.440', 'E05.540.500']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
The association between Facebook addiction and depression: A pilot survey study among Bangladeshi students. | Social media addiction has become an area of increasing research interest over the past few years. However, there has been no previous research on social media addiction in Bangladesh. The present pilot study is the first ever in Bangladesh to examine the relationship between one specific form of social media addiction... | ['Bangladesh', 'Behavior, Addictive', 'Comorbidity', 'Depression', 'Depressive Disorder', 'Female', 'Humans', 'Male', 'Pilot Projects', 'Prevalence', 'Social Media', 'Students', 'Young Adult'] | 30,791,335 | [['Z01.252.245.131'], ['F01.145.527.100.120'], ['N05.715.350.225', 'N06.850.490.687'], ['F01.145.126.350'], ['F03.600.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.750', 'E05.337.737', 'N05.715.360.330.720', 'N06.850.520.450.720'], ['E05.318.308.985.525.750', 'N01.224.935.597.750', 'N06.850.505.... | ['Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Named Groups [M]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
Photosensitization of electro-active microbes for solar assisted carbon dioxide transformation. | Tandem bio-inorganic platform by combining efficient light harvesting properties of nano-inorganic semiconductor cadmium sulfide (CdS) with biocatalytic ability of electro-active bacteria (EAB) towards carbon dioxide (CO2) conversion is reported. Sulfur was obtained from either cysteine (EAB-Cys-CdS) or hydrogen sulfid... | ['Acetic Acid', 'Acetobacterium', 'Biocatalysis', 'Cadmium Compounds', 'Carbon Dioxide', 'Clostridium', 'Cysteine', 'Electrons', 'Hydrogen Sulfide', 'Myricaceae', 'Pseudomonas', 'Sulfides', 'Sunlight'] | 30,366,289 | [['D02.241.081.018.165', 'D10.251.400.045.500'], ['B03.510.460.400.400.024'], ['G02.111.086', 'G02.130.500', 'G03.105'], ['D01.142'], ['D01.200.200', 'D01.362.150', 'D01.650.550.200'], ['B03.300.390.400.200', 'B03.353.625.375.500', 'B03.510.415.400.200'], ['D02.886.030.230', 'D02.886.489.155', 'D12.125.154.299', 'D12.1... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Fertility desires and fertility: hers, his, and theirs. | The relationship between desired and achieved fertility may be misspecified by excluding husbands' fertility desires or by confounding effects of shared desires with the resolution of conflicting desires. Using couple data from the classic Princeton Fertility Surveys, we find relatively large husband effects on fertili... | ['Birth Rate', 'Choice Behavior', 'Family Characteristics', 'Fathers', 'Female', 'Fertility', 'Humans', 'Male', 'Marriage', 'Mothers', 'Surveys and Questionnaires', 'United States'] | 2,249,746 | [['E05.318.308.985.775.500', 'N01.224.935.849.500', 'N06.850.505.400.975.775.500', 'N06.850.520.308.985.775.500'], ['F02.463.785.373.346'], ['F01.829.263.315', 'I01.240.361', 'I01.880.853.150.423', 'N01.224.361', 'N01.824.308', 'N06.850.505.400.400'], ['F01.829.263.500.320.100', 'I01.880.853.150.500.340.210', 'M01.620.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Development of autoimmune hepatitis following liver transplantation for primary biliary cirrhosis. | Two patients undergoing liver transplantation for classical end-stage primary biliary cirrhosis (PBC) are described, who went on to develop de novo autoimmune hepatitis (AIH) in the transplanted liver. The presentation, in both instances, was with malaise and lethargy. Markedly elevated serum transaminases were found, ... | ['Female', 'Hepatitis, Autoimmune', 'Histocompatibility Antigens Class I', 'Histocompatibility Testing', 'Humans', 'Immunoglobulin G', 'Immunosuppressive Agents', 'Liver Cirrhosis, Biliary', 'Liver Transplantation', 'Postoperative Complications', 'Sleep Stages', 'Tissue Donors'] | 10,385,638 | [['C06.552.380.350.300', 'C20.111.567'], ['D12.776.395.550.489', 'D12.776.543.550.439', 'D23.050.301.500.100', 'D23.050.705.552.100'], ['E01.370.225.812.385', 'E05.200.812.385', 'E05.478.594.385'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.124.486.485.114.619.393', 'D12.776.124.790.651.114.619.393', 'D... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Direct thymic involvement in anterior chamber-associated immune deviation: evidence for a nondeletional mechanism of centrally induced tolerance to extrathymic antigens in adult mice. | Recent reports have suggested that the dichotomy between central (thymic) and peripheral T cell tolerance is not absolute and that self-tolerance in perinatal animals may also involve the intrathymic generation and release to the periphery of Ag-specific immunoregulatory T cells. We have expanded this concept to includ... | ['Adoptive Transfer', 'Animals', 'Anterior Chamber', 'Antigens', 'Clonal Deletion', 'Epitopes', 'Female', 'Hypersensitivity, Delayed', 'Injections', 'Mice', 'Mice, Inbred BALB C', 'Phenotype', 'Serum Albumin, Bovine', 'T-Lymphocyte Subsets', 'Thymectomy', 'Thymus Gland', 'Trinitrobenzenes'] | 9,036,960 | [['E02.095.465.425.400.330.050', 'E05.478.550.520.050'], ['B01.050'], ['A09.371.060.067'], ['D23.050'], ['G12.535.425.120'], ['D23.050.550'], ['C20.543.418'], ['E02.319.267.530'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.338', 'B01.050.150.900.649.313.992.635.505.500.400.338'], ['G05.695']... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Divergent synthesis of L-sugars and L-iminosugars from D-sugars. | An efficient divergent synthesis of L-sugars and L-iminosugars from D-sugars is described. The important intermediate, delta-hydroxyalkoxamate, prepared from D-glucono-/galactono-1,5-lactone, was cyclized under Mitsunobu conditions to give the O-cyclized oxime compound and the N-cyclized lactam compound as mixtures. A ... | ['Carbohydrate Conformation', 'Carbohydrates', 'Cyclization', 'Iduronic Acid', 'Imino Sugars', 'Lactones', 'Siloxanes', 'Styrenes'] | 16,718,730 | [['G02.111.570.820.235'], ['D09'], ['G02.111.180', 'G02.607.133', 'G03.208'], ['D02.241.081.844.915.400.500', 'D02.241.152.811.400.500', 'D02.241.511.902.915.400.500', 'D09.811.922.400.500'], ['D02.491.567', 'D09.553'], ['D02.540'], ['D01.837.800', 'D02.756.650', 'D05.750.900', 'D25.720.900', 'J01.637.051.720.900'], ['... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
The effect of auditory verbal imagery on signal detection in hallucination-prone individuals. | Cognitive models have suggested that auditory hallucinations occur when internal mental events, such as inner speech or auditory verbal imagery (AVI), are misattributed to an external source. This has been supported by numerous studies indicating that individuals who experience hallucinations tend to perform in a biase... | ['Adolescent', 'Adult', 'Auditory Perception', 'Female', 'Hallucinations', 'Humans', 'Imagination', 'Male', 'Signal Detection, Psychological', 'Speech Perception', 'Young Adult'] | 26,435,050 | [['M01.060.057'], ['M01.060.116'], ['F02.463.593.071', 'G07.888.125'], ['C10.597.606.762.300', 'C23.888.592.604.764.300', 'F01.700.750.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.188.634'], ['E01.370.685.814', 'E05.796.908', 'F02.463.593.257.800', 'F02.463.593.710.725', 'F04.096.753.814', 'F04.669... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Effects of light intensity and dilution rate on the semicontinuous cultivation of Arthrospira (Spirulina) platensis. A kinetic Monod-type approach. | Semicontinuous cultures were carried out at different dilution rates (D) and light intensities (I) to determine the maximum productivity of Arthrospira platensis cultivated in helicoidal photobioreactor up to the achievement of pseudo-steady-state conditions. At I=108 ìmol photons m(-2) s(-1), the semicontinuous regime... | ['Cell Proliferation', 'Computer Simulation', 'Light', 'Models, Biological', 'Photobioreactors', 'Radiation Dosage', 'Spirulina'] | 21,111,613 | [['G04.161.750', 'G07.345.249.410.750'], ['L01.224.160'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['E05.599.395'], ['E07.115.600', 'J01.897.120.115.600'], ['E05.799.513', 'G01.750.740', 'N06.850.810.250'], ['B03.280.697']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 |
Forging alliances to meet future research and training needs. | There are countless challenges in meeting the future needs of the biomedical research community. In an era of flattened research budgets, the overarching concern has become how more can be done with less. One approach, still novel for the biomedical research community but proven successful for the commercial sector, is... | ['Humans', 'Interinstitutional Relations', 'Minority Groups', 'Models, Organizational', 'National Institutes of Health (U.S.)', 'Research', 'United States'] | 9,253,223 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['N04.452.822.400'], ['I01.880.853.300'], ['E05.599.670', 'N04.452.534'], ['I01.409.418.750.600.650.496', 'N03.540.052.750', 'N03.540.348.500.500.600.650.496'], ['H01.770.644'], ['Z01.107.567.875']] | ['Organisms [B]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 |
Effect of Gray strain infectious bronchitis virus and high dietary calcium on renal function of Single Comb White Leghorn pullets at 6, 10, and 18 weeks of age. | Experiments were designed to evaluate the effects of Gray strain infectious bronchitis virus (IBV) and high dietary calcium (Ca), alone and in combination, on renal function in pullets. Eight hundred female Single Comb White Leghorn chicks were raised on starter ration. Five hundred chicks were inoculated intravenously... | ['Age Factors', 'Animals', 'Calcium, Dietary', 'Chickens', 'Coronaviridae Infections', 'Female', 'Infectious bronchitis virus', 'Kidney', 'Poultry Diseases'] | 2,847,130 | [['N05.715.350.075', 'N06.850.490.250'], ['B01.050'], ['D01.146.395'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['C01.925.782.600.550'], ['B04.820.578.500.540.150.400.750'], ['A05.810.453'], ['C22.131.728']] | ['Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Acute type B viral hepatitis due to accidental transfusion of blood containing HBs Ag in a patient with liver cirrhosis. | Patients with liver cirrhosis have the opportunity of receiving blood transfusions rather frequently. Accidental transfusion of blood containing HBs Ag occurred in such a case. Recently, we encountered a case of hepatocellular carcinoma based on posthepatitic cirrhosis in which an emergency blood transfusion because of... | ['Carcinoma, Hepatocellular', 'Female', 'Hepatitis B', 'Hepatitis B Surface Antigens', 'Humans', 'Liver Cirrhosis', 'Liver Neoplasms', 'Middle Aged', 'Peptic Ulcer', 'Transfusion Reaction'] | 6,275,574 | [['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['C01.221.250.500', 'C01.925.256.430.400', 'C01.925.440.435', 'C06.552.380.705.437'], ['D23.050.327.495.500.475'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C06.552.630', 'C23.550.355.412'], ['C04.588.274.623', 'C06.301.... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Ethics, epidemiology, and women's health. | Ethical issues arise throughout the conduct of epidemiologic studies, in the processes of determining the study question, designing the protocol, and implementing the study. There also is an ethical dimension when studies are not done, for example, in studies of the effect of drugs and chemicals on male reproductive ca... | ['AIDS Serodiagnosis', 'Anonymous Testing', 'Clinical Trials as Topic', 'Epidemiology', 'Ethics, Medical', 'Federal Government', 'Female', 'Government Regulation', 'HIV Seroprevalence', 'Humans', 'Infant, Newborn', 'Mandatory Programs', 'Population Surveillance', 'Pregnant Women', 'Research', 'Voluntary Programs', "Wom... | 8,205,284 | [['E01.370.225.812.735.060', 'E01.370.225.875.408.500', 'E05.200.812.735.060', 'E05.200.875.408.500', 'E05.478.594.760.060'], ['E01.370.500.174', 'E05.318.308.980.438.580.174', 'N02.421.726.233.443.221', 'N05.715.360.300.800.438.500.174', 'N06.850.520.308.980.438.580.174', 'N06.850.780.500.162'], ['E05.318.372.250.250'... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Humanities [K]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 |
A type IV paraesophageal hernia containing a volvulized sigmoid colon. | A type IV paraesophageal hernia is a rare complication in esophageal hiatus and is an uncommon presentation of hiatal hernia. We report herein a 71-year-old man who presented with abdominal pain, nausea and constipation that was attributed to a sigmoid volvulus. At laparotomy, the sigmoid volvulus was identified as str... | ['Aged', 'Esophagus', 'Fundoplication', 'Hernia, Hiatal', 'Humans', 'Intestinal Volvulus', 'Male', 'Sigmoid Diseases'] | 18,197,947 | [['M01.060.116.100'], ['A03.556.875.500'], ['E04.210.390'], ['C23.300.707.960.500.467'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C06.405.469.531.568', 'C23.300.970.500'], ['C06.405.469.158.850']] | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A novel simultaneous measurement method to assess the influence of intracerebroventricular obestatin on colonic motility and secretion in conscious rats. | Obestatin, a novel putative 23-amino acid peptide, is derived from mammalian preproghrelin gene via a bioinformatics approach. Although obestatin regulates thirst, sleep, memory, anxiety, activates cortical neurons in the brain and stimulate proliferation of retinal pigment epithelial cells, there is no study to explor... | ['Animals', 'Colon', 'Corticotropin-Releasing Hormone', 'Defecation', 'Feces', 'Gastrointestinal Motility', 'Ghrelin', 'Humans', 'Injections, Intraventricular', 'Male', 'Rats', 'Rats, Sprague-Dawley'] | 20,338,205 | [['B01.050'], ['A03.556.124.526.356', 'A03.556.249.249.356'], ['D06.472.699.327.740.140', 'D12.644.400.400.740.140', 'D12.644.548.365.740.140', 'D12.776.631.650.405.740.140'], ['G10.261.165'], ['A12.459'], ['G10.261.360'], ['D06.472.699.301', 'D12.644.548.322'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.31... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Wollaston's effect in infants: Do infants integrate eye and head information in gaze perception? | The current study examined infants' sensitivity to Wollaston's effect: When identical eyes are placed in differently angled faces, the perceived gaze direction shifts toward the orientation of the face such that physically, the direct gaze is perceived as averted toward the orientation of the face. Consistent with Woll... | ['Female', 'Fixation, Ocular', 'Head', 'Humans', 'Infant', 'Male', 'Ocular Physiological Phenomena', 'Orientation', 'Psychophysics', 'Visual Perception'] | 26,842,857 | [['G14.350.253'], ['A01.456'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['G14'], ['F01.058.577', 'F02.830.606'], ['E01.370.685', 'F04.096.753'], ['F02.463.593.932']] | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Processing fixed and stored adipose-derived stem cells for quantitative protein array assays. | Accurately characterizing cellular subpopulations is essential for elucidating the mechanisms underlying normal and pathological biology. Isolation of specific cell types can be accomplished by labeling unique cell-associated proteins with fluorescent antibodies. Cell fixation is commonly used to prepare these samples ... | ['Adipose Tissue', 'Cell Adhesion Molecules', 'Cells, Cultured', 'Feasibility Studies', 'Fluorescent Antibody Technique', 'Formaldehyde', 'Humans', 'Protein Array Analysis', 'Stem Cells'] | 29,235,974 | [['A10.165.114'], ['D12.776.395.550.200', 'D12.776.543.550.200', 'D23.050.301.350'], ['A11.251'], ['E05.318.372.550', 'E05.337.675', 'N05.715.360.330.550', 'N06.850.520.450.550'], ['E01.370.225.500.607.512.240', 'E01.370.225.750.551.512.240', 'E05.200.500.607.512.240', 'E05.200.750.551.512.240', 'E05.478.583.375'], ['D... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Design and characterization of an eight-element passively fed meander-dipole array with improved specific absorption rate efficiency for 7 T body imaging. | OBJECTIVE: To evaluate the transmit efficiency and specific absorption rate (SAR) efficiency of a new eight-element passively fed meander-dipole antenna array designed for body MRI at 7 T, and to compare these values with a conventional directly fed meander-dipole array.METHODS: The main radiating element of the passiv... | ['Computer Simulation', 'Electricity', 'Equipment Design', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Phantoms, Imaging', 'Prostate'] | 31,131,944 | [['L01.224.160'], ['G01.358.500.249'], ['E05.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['E07.671'], ['A05.360.444.575', 'A10.336.707']] | ['Information Science [L]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Acute focal neurological deficits in aneurysmal subarachnoid hemorrhage: relation of clinical course, CT findings, and metabolite abnormalities monitored with bedside microdialysis. | BACKGROUND AND PURPOSE: We sought (1) to identify early metabolic markers for the development of (ir)reversible neurological deficits and cerebral infarction in subarachnoid hemorrhage (SAH) patients by using the microdialysis technique and (2) to evaluate the influence of intracerebral hemorrhage (ICH) on microdialysi... | ['Acute Disease', 'Biomarkers', 'Brain', 'Cerebral Angiography', 'Demography', 'Disease Progression', 'Female', 'Glucose', 'Glutamic Acid', 'Glycerol', 'Humans', 'Lactose', 'Male', 'Microdialysis', 'Middle Aged', 'Monitoring, Physiologic', 'Nervous System Diseases', 'Paresis', 'Predictive Value of Tests', 'Prospective ... | 12,750,537 | [['C23.550.291.125'], ['D23.101'], ['A08.186.211'], ['E01.370.350.578.937.180', 'E01.370.350.700.060.180', 'E01.370.350.700.560.180', 'E01.370.370.050.180', 'E01.370.376.537.750.180', 'E05.629.937.180'], ['I01.240', 'N01.224', 'N06.850.505.400'], ['C23.550.291.656'], ['D09.947.875.359.448'], ['D12.125.067.625.349', 'D1... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Do We Measure What Patients Feel?: An Analysis of Correspondence Between Somatosensory Modalities Upon Quantitative Sensory Testing and Self-reported Pain Experience. | OBJECTIVES: Hyperalgesia and allodynia are typical signs of neuropathic pain. Quantitative sensory testing (QST) is a validated tool to clinically assess these phenomena. However, whether QST reveals findings that are reported by the patients is unclear. The aim of this study was therefore to investigate the associatio... | ['Adult', 'Aged', 'Aged, 80 and over', 'Chronic Pain', 'Cold Temperature', 'Female', 'Hot Temperature', 'Humans', 'Hyperalgesia', 'Hypesthesia', 'Male', 'Middle Aged', 'Neuralgia', 'Pain Measurement', 'Pressure', 'Self Report', 'Touch', 'Young Adult'] | 29,271,799 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C23.888.592.612.274'], ['G01.906.595.272', 'G16.500.275.063.725.710.300', 'G16.500.750.775.710.300', 'N06.230.300.100.725.154', 'N06.230.300.100.725.710.300'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.775.710.380', 'N06.230.300.100... | ['Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Predictors of speech outcomes in children with Pierre Robin sequence. | BACKGOUND: Pierre Robin sequence (PRS) has worse speech outcomes than isolated cleft palate. We aimed to search for possible associations of phonological outcomes with PRS status (isolated vs syndromic), clinical severity, soft palate muscles deficiency, or surgical procedure.METHODS: We designed a retrospective study ... | ['Child', 'Cleft Palate', 'Female', 'Humans', 'Male', 'Pierre Robin Syndrome', 'Prognosis', 'Retrospective Studies', 'Speech', 'Treatment Outcome'] | 29,317,143 | [['M01.060.406'], ['C05.500.460.185', 'C05.660.207.540.460.185', 'C07.320.440.185', 'C07.465.525.185', 'C07.650.500.460.185', 'C07.650.525.185', 'C16.131.621.207.540.460.185', 'C16.131.850.500.460.185', 'C16.131.850.525.185'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C05.500.460.606', 'C05.660.207.540.460.606... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Information Science [L]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Diploid human lymphoblastoid and Burkitt lymphoma cell lines: susceptibility to murine NK cells and heterotransplantation to nude mice. | Human lymphoid cell lines which had been classified on the basis of studies on clonality and morphological, on the basis of studies on clonality and morphological, chromosomal and functional parameters as lymphoblastoid cell line (LCL) of presumed non-neoplastic origin and Burkitt lymphoma (BL) lines of proven malignan... | ['Animals', 'Burkitt Lymphoma', 'Cell Line', 'Cytotoxicity, Immunologic', 'Herpesvirus 4, Human', 'Humans', 'Killer Cells, Natural', 'Lymphocytes', 'Mice', 'Mice, Nude', 'Neoplasm Transplantation', 'Transplantation, Heterologous'] | 6,273,332 | [['B01.050'], ['C01.925.256.466.313.165', 'C01.925.928.313.165', 'C04.557.386.480.150.165', 'C15.604.515.569.480.150.165', 'C20.683.515.761.480.150.165'], ['A11.251.210'], ['G12.287'], ['B04.280.210.400.500.450', 'B04.280.382.400.500.400', 'B04.613.204.500.500.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A... | ['Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Comparison of Mortality Prediction Models on Long-Term Mortality in Hospitalized Patients With Acute Heart Failure?- The Importance of Accounting for Nutritional Status. | BACKGROUND: The ideal mortality prediction model (MPM) for acute heart failure (AHF) patients would have sufficient and stable predictive ability for long-term as well as short-term mortality. However, published MPMs for AHF predominantly predict short-term mortality up to 90 days, and their prognostic performance for ... | ['Acute Disease', 'Aged', 'Aged, 80 and over', 'Cholesterol', 'Female', 'Heart Failure', 'Hospitalization', 'Humans', 'Male', 'Middle Aged', 'Nutritional Status', 'Prognosis', 'Risk Assessment', 'Serum Albumin'] | 30,700,666 | [['C23.550.291.125'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['C14.280.434'], ['E02.760.400', 'N02.421.585.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['G07.203.650.650', 'N01.224.425.525'], ['E01.789'], [... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
High level expression of Ricinus communis casbene synthase in Escherichia coli and characterization of the recombinant enzyme. | Casbene synthase catalyzes the cyclization of geranylgeranyl diphosphate (2) to casbene (1), a diterpene phytoalexin with antibacterial and antifungal activity that is produced by seedlings of castor bean (Ricinus communis L.) in response to fungal attack. We report the high-level expression of casbene synthase cDNA in... | ['Castor Bean', 'Escherichia coli', 'Gas Chromatography-Mass Spectrometry', 'Inclusion Bodies', 'Lyases', 'Phosphorus-Oxygen Lyases', 'Plants, Toxic', 'Recombinant Proteins', 'Solubility'] | 8,954,576 | [['B01.650.940.800.575.912.250.859.797.438.650.300'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['E05.196.181.349.500', 'E05.196.566.500'], ['A11.284.420'], ['D08.811.520'], ['D08.811.520.650'], ['B01.650.660'], ['D12.776.828'], ['G02.805']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Autoregulation of I kappa B alpha activity. | Transcription factor NF-kappa B regulates the expression of a plethora of genes. The activity of NF-kappa B proteins is regulated by I kappa B proteins. We report that induction of I kappa B alpha, a member of the I kappa B family of proteins, is preceded by activation of NF-kappa B complex. The promoter of the I kappa... | ['Animals', 'Base Sequence', 'Cell Line', 'Cycloheximide', 'Gene Expression Regulation', 'Mice', 'Molecular Sequence Data', 'NF-kappa B', 'Oligodeoxyribonucleotides', 'Promoter Regions, Genetic', 'Proto-Oncogene Proteins', 'RNA, Messenger', 'Tosylphenylalanyl Chloromethyl Ketone', 'Transcription Factor RelB', 'Transcri... | 8,278,379 | [['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A11.251.210'], ['D03.383.621.808.240'], ['G05.308'], ['B01.050.150.900.649.313.992.635.505.500'], ['L01.453.245.667'], ['D05.500.672', 'D12.776.260.600', 'D12.776.660.600', 'D12.776.930.600'], ['D13.695.578.424.450'], ['G02.111.570.080.689.675',... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Adiponectin complexes in human cerebrospinal fluid: distinct complex distribution from serum. | AIMS/HYPOTHESIS: Adiponectin is an adipocyte-derived secretory factor that is specifically produced in adipocytes. It exerts effects on energy homeostasis via peripheral and central mechanisms. However, it is not clear whether adiponectin crosses the blood-brain barrier in humans. In serum, adiponectin circulates in se... | ['Adiponectin', 'Aged', 'Aged, 80 and over', 'Body Mass Index', 'European Continental Ancestry Group', 'Female', 'Humans', 'Male', 'Middle Aged', 'Molecular Weight'] | 17,242,917 | [['D06.472.699.042.249', 'D12.644.276.024.249', 'D12.644.548.011.249', 'D12.776.467.024.249', 'D23.529.024.249'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['M01.686.508.400'], ['B01.050.150.900.649.313.988.400.112.400.400... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Muscarinic and Nicotinic Contribution to Contrast Sensitivity of Macaque Area V1 Neurons. | Acetylcholine is a neuromodulator that shapes information processing in different cortical and subcortical areas. Cell type and location specific cholinergic receptor distributions suggest that acetylcholine in macaque striate cortex should boost feed-forward driven activity, while also reducing population excitability... | ['Action Potentials', 'Animals', 'Contrast Sensitivity', 'Macaca mulatta', 'Male', 'Mecamylamine', 'Microelectrodes', 'Models, Neurological', 'Muscarinic Antagonists', 'Neurons', 'Neuropsychological Tests', 'Nicotinic Antagonists', 'Photic Stimulation', 'Receptors, Muscarinic', 'Receptors, Nicotinic', 'Scopolamine', 'V... | 29,311,843 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['B01.050'], ['E01.370.380.850.950.500', 'F02.463.593.778.435.110', 'F02.463.593.932.281', 'F02.463.593.932.901.500', 'G14.940.500'], ['B01.050.150.900.649.313.988.400.112.199.120.510.550'], ['D02.455.426.100.080.550.500', 'D04.075.080.500.500'], ['E07.305.250.500... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Rhizobacteria-mediated resistance against the blackeye cowpea mosaic strain of bean common mosaic virus in cowpea (Vigna unguiculata). | BACKGROUND: The present study investigated the effect of seven Bacillus-species plant-growth-promoting rhizobacteria (PGPR) seed treatments on the induction of disease resistance in cowpea against mosaic disease caused by the blackeye cowpea mosaic strain of bean common mosaic virus (BCMV).RESULTS: Initially, although ... | ['Bacillus', 'Comovirus', 'Fabaceae', 'Immunity, Innate', 'Plant Diseases', 'Plant Roots', 'Seeds'] | 19,569,083 | [['B03.300.390.400.158.218', 'B03.353.500.100.218', 'B03.510.100.100.218', 'B03.510.415.400.158.218', 'B03.510.460.410.158.218'], ['B04.715.464.150', 'B04.715.700.150', 'B04.820.578.813.150'], ['B01.650.940.800.575.912.250.401'], ['G12.450.564'], ['G15.610'], ['A18.400'], ['A18.024.500.750', 'G07.203.300.775', 'J02.500... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Evaluation of (13C)ethanol incorporation into very-low-density lipoprotein triglycerides using gas chromatography/isotope ratio mass spectrometry coupling. | Gas chromatography/isotope ratio mass spectrometry (GC/IRMS) coupling was used to evaluate (13C)ethanol incorporation into plasmatic very-low-density lipoprotein (VLDL) triglycerides of three healthy human volunteers. After the perfusion of 13C-enriched alcohol, VLDL triglyceride fractions were extracted from plasma sa... | ['Carbon Isotopes', 'Ethanol', 'Gas Chromatography-Mass Spectrometry', 'Humans', 'Lipoproteins, VLDL', 'Triglycerides'] | 1,812,987 | [['D01.268.150.075', 'D01.496.123'], ['D02.033.375'], ['E05.196.181.349.500', 'E05.196.566.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D10.532.599', 'D12.776.521.622'], ['D10.351.801']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Methods of dynamic spectral analysis by self-exciting autoregressive moving average models and their application to analysing biosignals. | Dynamic methods in the spectral domain are necessary to analyse biological signals because of the frequently nonstationary character of the signals. The paper presents an adaptive procedure of fitting time-dependent ARMA models to nonstationary signals, which is suitable for on-line calculations. The properties of the ... | ['Electroencephalography', 'Flow Cytometry', 'Humans', 'Image Processing, Computer-Assisted', 'Mathematics', 'Models, Biological'] | 7,666,700 | [['E01.370.376.300', 'E01.370.405.245'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.200.500.386.350', 'E05.242.363.342', 'E05.242.386.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['H01.548'], ['E05.599.395']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Information Science [L]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Maternal viral load and vertical transmission of HIV-1 in mid-trimester gestation. | BACKGROUND: It is now accepted that the majority of HIV-1 vertical transmissions occur in late gestation and at the time of delivery. However, there is wide variation in the prevalence rate of mid-trimester vertical transmission. We assessed the maternal HIV-1 RNA viral load and in utero transmission during mid-trimest... | ['Adult', 'Female', 'HIV Infections', 'HIV-1', 'Humans', 'Infectious Disease Transmission, Vertical', 'Pregnancy', 'Pregnancy Complications, Infectious', 'Pregnancy Trimester, Second', 'Viral Load'] | 10,513,652 | [['M01.060.116'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['B04.820.650.589.650.350.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N06.850.335.875'], ['G08.686.784.769'], ['C01.674', 'C13.703.700'], ['G08.686.707.490'], ['E01... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Effect of microalgae on intestinal inflammation triggered by soybean meal and bacterial infection in zebrafish. | Soybean meal has been used in many commercial diets for farm fish; despite this component inducing intestinal inflammation. On the other hand, microalgae have increasingly been used as dietary supplements in fish feed. Nevertheless, the vast quantity of microalgae species means that many remain under- or unstudied, thu... | ['Animal Feed', 'Animals', 'Bacterial Infections', 'Dietary Supplements', 'Edwardsiella tarda', 'Fish Diseases', 'Inflammation', 'Intestines', 'Microalgae', 'Neutrophils', 'Soybeans', 'Zebrafish'] | 29,117,213 | [['G07.203.300.300.100', 'J02.500.300.100'], ['B01.050'], ['C01.150.252'], ['G07.203.300.456', 'J02.500.456'], ['B03.440.450.425.260.750', 'B03.660.250.150.160.750'], ['C22.362'], ['C23.550.470'], ['A03.556.124'], ['B05.080.500.600.500'], ['A11.118.637.415.583', 'A11.627.340.583', 'A11.733.689', 'A15.145.229.637.415.58... | ['Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Selective polarization transfer using a single rf field. | NMR is a popular and mature technique used in fields as diverse as chemistry, biology, or material science. One reason for this versatility lies in its ability to correlate the nuclei that are present in one molecule to another. This provides the researcher with correlation maps allowing for studies of the molecules at... | ['Magnetic Resonance Spectroscopy', 'Magnetics', 'Sensitivity and Specificity'] | 18,624,480 | [['E05.196.867.519'], ['H01.671.493'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700', 'N05.715.360.750.725', 'N06.850.520.445.800', 'N06.850.520.830.872']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
[Identification of Salmonella typhi phage types 1991-1996 in the Slovak Republic]. | A total of 102 strains of Salmonella typhi were received at the National Salmonella Phage Typing Centre at Bratislava during January 1991-December 1996 from various regions of the Slovak Republic. From these, 24 strains were isolated and confirmed by cultivation from patients with typhoid fever and 78 strains were isol... | ['Bacteriophage Typing', 'Carrier State', 'Humans', 'Salmonella typhi', 'Slovakia', 'Typhoid Fever'] | 9,611,893 | [['E01.370.225.875.150.125.150', 'E05.200.875.150.125.150'], ['N06.850.520.169'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B03.440.450.425.800.200.800', 'B03.660.250.150.710.160.750'], ['Z01.542.248.797'], ['C01.150.252.400.310.821.873']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Pulmonary hydatid cysts: the naturally occurring models for rupture. | BACKGROUND: Pulmonary hydatid cysts are recognized to have high rate of rupture compared to those in other affected organs. To identify risk factors associated with endobronchial rupture, we prospectively assessed 32 patients with hydatid cysts. There were 21 males and 11 females, with a mean age of 32 ± 15 years (rang... | ['Adolescent', 'Adult', 'Aged', 'Bronchial Fistula', 'Bronchoscopy', 'Child', 'Echinococcosis, Pulmonary', 'Female', 'Humans', 'Logistic Models', 'Male', 'Middle Aged', 'Multivariate Analysis', 'Pressure', 'Prospective Studies', 'Risk Factors', 'Rupture, Spontaneous', 'Saudi Arabia', 'Thoracotomy', 'Young Adult'] | 27,432,057 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['C08.127.196', 'C08.702.196', 'C23.300.575.687.225'], ['E01.370.386.105', 'E01.370.388.250.100', 'E04.502.250.100', 'E04.928.600.080'], ['M01.060.406'], ['C01.610.335.190.396.480', 'C01.610.582.314', 'C01.748.450.314', 'C08.381.517.314', 'C08.730.450.314'], ['B01... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Nitrogen and phosphorus removed from a subsurface flow multi-stage filtration system purifying agricultural runoff. | Agricultural nonpoint source pollution has been increasingly serious in China since the 1990s. The main causes were excessive inputs of nitrogen fertilizer and pesticides. A multi-stage filtration system was built to test the purification efficiencies and removal characteristics of nitrogen and phosphorus when treating... | ['China', 'Environmental Monitoring', 'Nitrogen', 'Phosphorus', 'Water Movements', 'Water Pollutants, Chemical', 'Water Purification'] | 28,562,188 | [['Z01.252.474.164'], ['N06.850.460.350.080', 'N06.850.780.375'], ['D01.268.604', 'D01.362.625'], ['D01.268.666'], ['G16.500.971', 'N06.230.132.644.750', 'N06.230.850'], ['D27.888.284.903.655'], ['N06.850.780.200.800.800.900.900', 'N06.850.860.510.900.900']] | ['Geographicals [Z]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
A homologue of Cdk8 is required for spore cell differentiation in Dictyostelium. | The Cdk8 proteins are kinases which phosphorylate the carboxy terminal domain (CTD) of RNA polymerase II (Pol II) as well as some transcription factors and, therefore, are involved in the regulation of transcription. Here, we report that a Cdk8 homologue from Dictyostelium discoideum is localized in the nucleus where i... | ['Animals', 'Blotting, Northern', 'Chemotaxis', 'Chromatography, Gel', 'Dictyostelium', 'Fluorescent Antibody Technique', 'Gene Expression Regulation, Developmental', 'Gene Library', 'Mutagenesis, Insertional', 'Phenotype', 'Precipitin Tests', 'Sequence Analysis, DNA', 'Spores', 'Transfection', 'beta-Galactosidase'] | 15,196,949 | [['B01.050'], ['E05.196.401.095', 'E05.301.300.074', 'E05.601.100'], ['F01.145.113.780.500', 'F01.145.875.439.500.500', 'G04.198.424', 'G07.568.500.590.500', 'G11.427.410.568.850.500'], ['E05.196.181.400.250'], ['B01.046.550.200.300'], ['E01.370.225.500.607.512.240', 'E01.370.225.750.551.512.240', 'E05.200.500.607.512.... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Visual field global indices in patients with reversal of glaucomatous cupping after intraocular pressure reduction. | The authors investigated visual field changes in 28 eyes of 28 adult patients with early-to-moderate chronic open-angle glaucoma (COAG) in whom reversal of glaucomatous disc cupping was documented by computerized image analysis (Rodenstock Optic Nerve Head Analyzer) after intraocular pressure (IOP) reduction from 29.3 ... | ['Adult', 'Aged', 'Chronic Disease', 'Female', 'Glaucoma, Open-Angle', 'Humans', 'Image Processing, Computer-Assisted', 'Intraocular Pressure', 'Male', 'Middle Aged', 'Ophthalmic Solutions', 'Optic Disk', 'Trabeculectomy', 'Visual Fields'] | 1,945,318 | [['M01.060.116'], ['M01.060.116.100'], ['C23.550.291.500'], ['C11.525.381.407'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['G14.440'], ['M01.060.116.630'], ['D26.776.708.645', 'D27.505.954.578.645', 'D27.720.752.608'], ['A08.800.800.120.680.660', 'A09.371.729.690'], ['E04.540.450.700'], ['F02.4... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Information Science [L]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Voltage-dependent elements are involved in the generation of the cochlear microphonic and the sound-induced resistance changes measured in scala media of the guinea pig. | The injection of d.c. current into scale media alters both the cochlear microphonic (CM) and the acoustically synchronized changing resistance (CR) measured in scala media. Positive current increases the CM and decreases the CR. The effect on the CM is greatest at high sound pressure level (SPL), whereas the effect on ... | ['Acoustic Stimulation', 'Animals', 'Cochlea', 'Cochlear Duct', 'Cochlear Microphonic Potentials', 'Evoked Potentials, Auditory', 'Guinea Pigs', 'Hair Cells, Auditory', 'Hypoxia'] | 7,440,425 | [['E02.037', 'E02.190.888.030', 'E05.723.136'], ['B01.050'], ['A09.246.300.246'], ['A09.246.300.246.292'], ['G07.265.216.500.370.223', 'G07.888.250.223', 'G11.561.200.500.370.223'], ['G07.265.216.500.370', 'G07.888.250', 'G11.561.200.500.370'], ['B01.050.150.900.649.313.992.550'], ['A08.675.650.250', 'A08.675.650.915.7... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cesarean: changing the trends. | A rising cesarean birth rate, both nationally and at our institution, led us to attempt to reverse the trend. Vaginal birth after cesarean (VBAC) was introduced as an alternative to repeat cesarean in 1982. The impact of VBAC on the cesarean rate for our institution was assessed from 1982-1988. Over the period studied,... | ['Adult', 'Cesarean Section', 'Chicago', 'Female', 'Hospitals, Maternity', 'Humans', 'Pregnancy', 'Reoperation', 'Vaginal Birth after Cesarean'] | 1,988,880 | [['M01.060.116'], ['E04.520.252.500'], ['Z01.107.567.875.350.350.200', 'Z01.107.567.875.510.350.200', 'Z01.433.305'], ['N02.278.421.556.366'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G08.686.784.769'], ['E04.690'], ['E04.520.252.992']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Community pharmacy service users' views and perceptions of alcohol screening and brief intervention. | INTRODUCTION AND AIMS: Community pharmacists have the potential to deliver alcohol screening and brief interventions (SBI) to pharmacy users. However, little is known if SBI would be utilised and views of people who might use the service. Therefore, the aim was to investigate potential barriers and enablers of pharmacy... | ['Adolescent', 'Adult', 'Age Factors', 'Alcohol Drinking', 'Alcoholism', 'Child', 'Community Pharmacy Services', 'Counseling', 'Ethanol', 'Female', 'Humans', 'Interviews as Topic', 'Male', 'Mass Screening', 'Middle Aged', 'Pharmacists', 'Surveys and Questionnaires', 'Young Adult'] | 20,973,842 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['F01.145.317.269'], ['C25.775.100.250', 'F03.900.100.350'], ['M01.060.406'], ['N02.421.143.221', 'N02.421.668.274'], ['F02.784.176', 'F04.408.413', 'N02.421.143.303', 'N02.421.461.363'], ['D02.033.375'], ['B01.050.150.900.649.313.988.400.112.40... | ['Named Groups [M]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Limits on CPP survivor benefits for same-sex couples unconstitutional. | On 19 December 2003, the Ontario Superior Court of Justice declared the federal government's Canada Pension Plan (CPP) survivor benefits regime as it applied to same-sex couples unconstitutional. Under the law, survivors in same-sex relationships could not receive benefits if their partner had died prior to 1 January 1... | ['Homosexuality', 'Humans', 'Ontario', 'Spouses'] | 15,216,837 | [['F01.145.802.975.500', 'G08.686.867.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.107.567.176.639'], ['F01.829.263.500.660', 'I01.880.853.150.500.670', 'M01.816']] | ['Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Named Groups [M]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 |
Prenatal alcohol exposure is associated with conduct disorder in adolescence: findings from a birth cohort. | OBJECTIVE: To evaluate the association between prenatal alcohol exposure and the rate of conduct disorder in exposed compared with unexposed adolescents.METHOD: Data for these analyses are from a longitudinal study of prenatal substance exposures. Women were interviewed at their fourth and seventh prenatal months, and ... | ['Adolescent', 'Adult', 'Alcohol Drinking', 'Alcohol-Related Disorders', 'Child', 'Child, Preschool', 'Conduct Disorder', 'Diagnostic and Statistical Manual of Mental Disorders', 'Female', 'Fetal Alcohol Spectrum Disorders', 'Humans', 'Infant', 'Infant, Newborn', 'Longitudinal Studies', 'Maternal-Fetal Exchange', 'Preg... | 21,334,566 | [['M01.060.057'], ['M01.060.116'], ['F01.145.317.269'], ['C25.775.100', 'F03.900.100'], ['M01.060.406'], ['M01.060.406.448'], ['F03.625.094.300'], ['L01.453.245.945.200'], ['C13.703.277.220', 'C16.300.070', 'C25.775.100.087.323'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Thrombotic Primary Antiphospholipid Syndrome: the profile of antibody positivity in patients from North India. | AIM: We evaluated the frequency of antiphospholipid antibody syndrome (APS) in patients presenting with thrombosis of various vascular beds from North India and report the antibody profiles encountered.PATIENTS AND METHODS: A retrospective analysis was performed on the laboratory results of aCL (anticardiolipin), aâ2 G... | ['Adolescent', 'Adult', 'Aged', 'Antibodies, Anticardiolipin', 'Antibodies, Antiphospholipid', 'Antiphospholipid Syndrome', 'Biomarkers', 'Blood Coagulation', 'Blood Coagulation Tests', 'Child', 'Child, Preschool', 'Enzyme-Linked Immunosorbent Assay', 'Female', 'Humans', 'India', 'Infant', 'Infant, Newborn', 'Lupus Coa... | 25,292,011 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['D12.776.124.486.485.114.323.210.100', 'D12.776.124.790.651.114.323.210.100', 'D12.776.377.715.548.114.323.210.100'], ['D12.776.124.486.485.114.323.210', 'D12.776.124.790.651.114.323.210', 'D12.776.377.715.548.114.323.210'], ['C20.111.197'], ['D23.101'], ['G09.18... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Tetanus in the adult: intensive care and management experience with 233 cases. | Over a period of 10 years, 233 adult patients were treated for severe tetanus in this ICU. Criteria of severity, clinical patterns, and a detailed plan of treatment are outlined. The authors emphasize that such treatment implicates the permanent availability of trained personel in handling cardiorespiratory emergencies... | ['Anti-Bacterial Agents', 'Anticonvulsants', 'Heart Arrest', 'Humans', 'Respiratory Insufficiency', 'Respiratory Tract Infections', 'Tetanus', 'Water-Electrolyte Imbalance'] | 7,408,509 | [['D27.505.954.122.085'], ['D27.505.954.427.080'], ['C14.280.383'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C08.618.846'], ['C01.748', 'C08.730'], ['C01.150.252.410.222.864'], ['C18.452.950']] | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Efficacy of Haemophilus influenzae type b vaccines in Massachusetts children 18 to 59 months of age. | Since 1987 Haemophilus influenzae b (Hib) conjugate vaccines have been licensed for use in children ages 18 months and older. Before licensure there were no clinical trials of a single dose of any conjugate vaccine in children ages 18 months or older. To fulfill this need we performed an age- and residence-matched case... | ['Bacterial Capsules', 'Bacterial Proteins', 'Bacterial Vaccines', 'Case-Control Studies', 'Child, Preschool', 'Diphtheria Toxoid', 'Female', 'Haemophilus Infections', 'Haemophilus Vaccines', 'Haemophilus influenzae', 'Humans', 'Infant', 'Male', 'Massachusetts', 'Polysaccharides, Bacterial', 'Statistics as Topic'] | 1,630,857 | [['A20.186'], ['D12.776.097'], ['D20.215.894.135'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['M01.060.406.448'], ['D20.215.894.691.263'], ['C01.150.252.400.700.433'], ['D20.215.894.135.450'], ['B03.440.450.600.450.330', 'B03.660.250.550.290.330'], ['B01.050.150.900.649.313.988.400... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
Oral Bicarbonate Slows Decline of Residual Renal Function in Peritoneal Dialysis Patients. | BACKGROUND/AIMS: Metabolic acidosis is a common consequence of end-stage renal disease (ESRD) which may result in a substantial adverse outcome. The effect of oral bicarbonate on the preservation of residual renal function (RRF) in peritoneal dialysis (PD) patients has been rarely reported.METHODS: We randomly assigned... | ['Acidosis', 'Adult', 'Aged', 'Bicarbonates', 'Creatinine', 'Female', 'Humans', 'Kidney Failure, Chronic', 'Male', 'Middle Aged', 'Peritoneal Dialysis, Continuous Ambulatory'] | 29,032,379 | [['C18.452.076.176'], ['M01.060.116'], ['M01.060.116.100'], ['D01.200.275.150.100', 'D01.248.497.158.165.100'], ['D03.383.129.308.207'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.777.419.780.750.500', 'C13.351.968.419.780.750.500'], ['M01.060.116.630'], ['E02.760.106.500', 'E02.870.300.650.500', 'E02.912.8... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Site-directed mutagenesis of the GTP-binding domain of beta-tubulin. | Tubulin binds guanine nucleotides with high affinity and specificity. GTP, an allosteric effector of microtubule assembly, requires Mg2+ for its interaction with beta-tubulin and binds as the MgGTP complex. In contrast, GDP binding does not require Mg2+. The structural basis for this difference is not understood but ma... | ['Amino Acid Sequence', 'Animals', 'Binding Sites', 'Cattle', 'Guanosine Triphosphate', 'In Vitro Techniques', 'Molecular Sequence Data', 'Mutagenesis, Site-Directed', 'Polymers', 'Protein Binding', 'Structure-Activity Relationship', 'Tubulin'] | 1,522,595 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.120'], ['B01.050.150.900.649.313.500.380.271'], ['D03.633.100.759.646.454.504', 'D13.695.667.454.504', 'D13.695.827.426.504'], ['E05.481'], ['L01.453.245.667'], ['E05.393.420.601.575'], ['D05.750', 'D25.720', 'J01.637.051.720'], ['G02.111.679', 'G0... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
2-[2-Substituted-3-(3,4-dichlorobenzylamino)propylamino]-1H-quinolin-4-ones as Staphylococcus aureus methionyl-tRNA synthetase inhibitors. | New analogues of 2-[2-substituted-3-(3,4-dichlorobenzylamino)propylamino]quinolin-4-ones, 26a, 26b, 31a-e, 34, 35, 38 and 40, have been synthesized and evaluated against Staphylococcus aureus methionyl-tRNA synthetase. All of the synthesized compounds were less active than the reference compound 2. The compounds were a... | ['Anti-Bacterial Agents', 'Enterococcus', 'Methionine-tRNA Ligase', 'Microbial Sensitivity Tests', 'Quinolones', 'Staphylococcus aureus'] | 18,403,059 | [['D27.505.954.122.085'], ['B03.353.750.250.250', 'B03.510.550.250.250'], ['D08.811.464.263.200.600'], ['E01.370.225.875.595', 'E05.200.875.595', 'E05.337.550.400'], ['D03.633.100.810.835'], ['B03.300.390.400.800.750.100', 'B03.353.500.750.750.100', 'B03.510.100.750.750.100', 'B03.510.400.790.750.100']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Reparative changes following oxygen-induced lung injury: effect on serotonin disposition and metabolism. | Exposure of mice to normobaric 100% oxygen for 72 hr has been shown to damage lung capillary endothelial cells and to markedly alter the pulmonary disposition and metabolism of endogenous serotonin (5-HT) and exogenous [3H]5-HT in a time-dependent manner. We have extended these studies to examine the reparative changes... | ['Animals', 'Blood Platelets', 'Capillaries', 'Lung', 'Male', 'Mice', 'Monoamine Oxidase', 'Oxygen', 'Peptidyl-Dipeptidase A', 'Serotonin', 'Thrombocytopenia'] | 6,312,629 | [['B01.050'], ['A11.118.188', 'A15.145.229.188'], ['A07.015.461.165'], ['A04.411'], ['B01.050.150.900.649.313.992.635.505.500'], ['D08.811.682.664.750'], ['D01.268.185.550', 'D01.362.670'], ['D08.811.277.656.350.350.687'], ['D02.092.211.215.801.852', 'D03.633.100.473.914.814', 'D23.469.050.650'], ['C15.378.140.855']] | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Altrenogest treatment before weaning improves litter size in sows. | The study aimed to assess whether altrenogest treatment, fed before weaning (from -8 to -2 days), could improve fertility of sows showing reproductive seasonality. Ninety sows (50 in winter-spring [WS] and 40 in summer-autumn [SA]) were randomly selected and assigned to control (C; 27 in WS and 20 in SA) or altrenogest... | ['Animals', 'Estrus', 'Female', 'Insemination, Artificial', 'Lactation', 'Litter Size', 'Male', 'Ovarian Follicle', 'Pregnancy', 'Progestins', 'Sus scrofa', 'Trenbolone Acetate'] | 29,052,320 | [['B01.050'], ['G08.686.195.500'], ['E02.875.800.937', 'E05.820.800.937', 'G08.686.784.363.492'], ['G08.686.523', 'G08.686.702.500'], ['G08.686.530', 'G08.686.784.769.498.300'], ['A05.360.319.114.630.535', 'A06.300.312.497.535'], ['G08.686.784.769'], ['D27.505.696.399.472.858'], ['B01.050.150.900.649.313.500.880.399'],... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Double labeling of S-phase murine cells with bromodeoxyuridine and a second DNA-specific probe. | A rapid method has been developed which combines immunofluorescence and autoradiography and permits the double labeling of DNA. P388 murine leukemic cells were incubated with bromodeoxyuridine and tritiated thymidine simultaneously. After fixation, the sample was first processed with a monoclonal antibody to bromodeoxy... | ['Animals', 'Antibodies, Monoclonal', 'Autoradiography', 'Bromodeoxyuridine', 'Cell Cycle', 'Cytarabine', 'DNA', 'Leukemia P388', 'Mice', 'Thymidine', 'Tritium'] | 3,986,772 | [['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['E01.370.225.750.132', 'E05.200.750.132', 'E05.799.256'], ['D03.383.742.680.852.300.150', 'D13.570.230.430.196', 'D13.570.685.852.300.150'], ['G04.144'], ['D03.383.742.680.245.453', 'D13.570.065.300', 'D13.570.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
An investigation of the role of transmembrane domains in Golgi protein retention. | The single transmembrane domains (TMDs) of the resident glycosylation enzymes of the Golgi apparatus are involved in preventing these proteins moving beyond the Golgi. It has been proposed that either the TMDs associate, resulting in the formation of large oligomers of Golgi enzymes, or that they mediate the lateral se... | ['Amino Acid Sequence', 'Animals', 'Base Sequence', 'Biological Transport', 'CD8 Antigens', 'Cell Membrane', 'Glycosyltransferases', 'Golgi Apparatus', 'Molecular Sequence Data', 'Mutation', 'Oligopeptides', 'Phenylalanine', 'Protein Sorting Signals', 'Rats', 'Recombinant Fusion Proteins', 'Sialyltransferases'] | 7,588,599 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G03.143'], ['D23.050.301.264.894.108', 'D23.101.100.894.108'], ['A11.284.149'], ['D08.811.913.400'], ['A11.284.430.214.190.875.336'], ['L01.453.245.667'], ['G05.365.590'], ['D12.644.456'], ['D12.125.07... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Management of chemotherapy-induced neutropenia in patients with cancer: 2019 guidelines of the Italian Medical Oncology Association (AIOM). | Neutropenia is the most frequent side effect of commercially available myelosuppressive drugs and its most significant complication is febrile neutropenia. It is associated with increased hospital admissions and higher probability of death. Prophylaxis with the administration of granulocyte colony-stimulating factor ca... | ['Antineoplastic Agents', 'Disease Management', 'Granulocyte Colony-Stimulating Factor', 'Guidelines as Topic', 'Humans', 'Induction Chemotherapy', 'Neoplasms', 'Neutropenia'] | 32,538,316 | [['D27.505.954.248'], ['N04.590.607'], ['D12.644.276.374.410.240.350', 'D12.776.395.240.200', 'D12.776.467.374.410.240.350', 'D23.529.374.410.240.350'], ['N04.761.700.350', 'N05.700.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.499', 'E02.860.500'], ['C04'], ['C15.378.553.546.184.564']] | ['Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Physiologic mechanism of discordance between instantaneous wave-free ratio and fractional flow reserve: Insight from 13 | BACKGROUND: Invasive physiologic indices, such as fractional flow reserve (FFR) or instantaneous wave-free ratio (iFR), are used in clinical practice. We sought to evaluate the physiological mechanism of discordance between iFR and FFR using 13N-ammonia positron emission tomography (PET)-derived quantitative parameters... | ['Aged', 'Ammonium Compounds', 'Blood Flow Velocity', 'Coronary Stenosis', 'Female', 'Fractional Flow Reserve, Myocardial', 'Humans', 'Male', 'Middle Aged', 'Nitrogen Radioisotopes', 'Positron-Emission Tomography', 'Registries'] | 28,600,102 | [['M01.060.116.100'], ['D01.625.062'], ['E01.370.370.130', 'G09.330.380.630.080'], ['C14.280.647.250.285', 'C14.907.585.250.285'], ['G09.330.100.324.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['D01.268.604.500.520', 'D01.362.625.500.520', 'D01.496.586.520', 'D01.496.749.615'], ['E01.37... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Molecular dynamics simulations of ribonuclease T1: comparison of the free enzyme and the 2' GMP-enzyme complex. | Molecular dynamics simulations were performed on free RNase T1 and the 2'GMP-RNase T1 complex in vacuum and with water in the active site along with crystallographically identified waters, allowing analysis of both active site and overall structural and dynamics changes due to the presence of 2'GMP. Differences in the ... | ['Binding Sites', 'Computer Simulation', 'Endoribonucleases', 'Fluorescence Polarization', 'Fungal Proteins', 'Guanine Nucleotides', 'Guanosine Monophosphate', 'Models, Molecular', 'Protein Binding', 'Protein Conformation', 'Ribonuclease T1', 'Tryptophan', 'Tyrosine', 'X-Ray Diffraction'] | 2,558,378 | [['G02.111.570.120'], ['L01.224.160'], ['D08.811.277.352.355.350', 'D08.811.277.352.700.350'], ['E05.196.712.516.600.390'], ['D12.776.354'], ['D03.633.100.759.646.454', 'D13.695.667.454', 'D13.695.827.426'], ['D03.633.100.759.646.454.400', 'D13.695.667.454.400', 'D13.695.827.426.400'], ['E05.599.595'], ['G02.111.679', ... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Hypertrophy of the tongue associated with inhaled corticosteroid therapy in premature infants. | We describe three infants in whom hypertrophy of the tongue developed while they were receiving beclomethasone inhalation therapy. The condition resolved after cessation of treatment, an outcome suggesting that tongue hypertrophy is a possible side effect of this therapy. | ['Administration, Inhalation', 'Adrenal Cortex Hormones', 'Bronchopulmonary Dysplasia', 'Dexamethasone', 'Female', 'Humans', 'Hypertrophy', 'Infant, Newborn', 'Infant, Premature', 'Male', 'Tongue'] | 7,562,295 | [['E02.319.267.050'], ['D06.472.040'], ['C08.381.520.750.500', 'C16.614.521.125'], ['D04.210.500.745.432.769.344', 'D04.210.500.908.238'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.300.775'], ['M01.060.703.520'], ['M01.060.703.520.520'], ['A03.556.500.885', 'A14.549.885']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Identification and biological activities of a new antiangiogenic small molecule that suppresses mitochondrial reactive oxygen species. | Mitochondrial reactive oxygen species (ROS) are associated with multiple cellular functions such as cell proliferation, differentiation, and apoptosis. In particular, high levels of mitochondrial ROS in hypoxic cells regulate many angiogenesis-related diseases, including cancer and ischemic disorders. Here we report a ... | ['Angiogenesis Inhibitors', 'Cell Hypoxia', 'Cell Line, Tumor', 'Cells, Cultured', 'Chorioallantoic Membrane', 'Humans', 'Hydrazones', 'Hypoxia', 'Mitochondria', 'Neovascularization, Physiologic', 'Nitroimidazoles', 'Reactive Oxygen Species', 'Small Molecule Libraries'] | 21,144,820 | [['D27.505.696.377.077.099', 'D27.505.696.377.450.100', 'D27.505.954.248.025'], ['G03.197.300', 'G04.270.300'], ['A11.251.210.190', 'A11.251.860.180'], ['A11.251'], ['A10.615.284.375', 'A13.350.575', 'A16.331.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.442.288'], ['C23.888.852.079'], ['A11.284.430.214... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Enhanced biofuel production potential with nutritional stress amelioration through optimization of carbon source and light intensity in Scenedesmus sp. CCNM 1077. | Microalgal mixotrophic cultivation is one of the most potential ways to enhance biomass and biofuel production. In the present study, first of all ability of microalgae Scenedesmus sp. CCNM 1077 to utilize various carbon sources under mixotrophic growth condition was evaluated followed by optimization of glucose concen... | ['Biofuels', 'Biomass', 'Biotechnology', 'Carbon', 'Diuron', 'Glucose', 'Light', 'Microalgae', 'Photosynthesis', 'Pigments, Biological', 'Scenedesmus', 'Stress, Physiological'] | 25,579,231 | [['D20.147', 'N06.230.132.644.124'], ['G16.500.275.157.100', 'N06.230.124.100'], ['H01.158.550', 'J01.897.120'], ['D01.268.150'], ['D02.065.950.681.397', 'D02.455.426.559.389.703.397'], ['D09.947.875.359.448'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['B05.080.500.600.500'], ['G02.... | ['Chemicals and Drugs [D]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 |
Analysis of differential gene expression mediated by clozapine in human postmortem brains. | Clozapine is the only medication indicated for treating refractory schizophrenia, due to its superior efficacy among all antipsychotic agents, but its mechanism of action is poorly understood. To date, no studies of human postmortem brain have characterized the gene expression response to clozapine. Therefore, we addre... | ['Antipsychotic Agents', 'Autopsy', 'Brain', 'Clozapine', 'Databases, Bibliographic', 'Female', 'Gene Expression', 'Humans', 'Male', 'Schizophrenia', 'Signal Transduction'] | 28,038,920 | [['D27.505.696.277.950.040', 'D27.505.954.427.210.950.040', 'D27.505.954.427.700.872.331'], ['E01.370.060', 'E05.070', 'I01.198.780.937.120'], ['A08.186.211'], ['D03.633.300.240.220'], ['L01.313.500.750.300.188.300', 'L01.470.750.500'], ['G05.297'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F03.700.750'], ['G0... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Anatomy [A]', 'Information Science [L]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 |
Increased Gal-9 and Tim-3 expressions during liver damage in a murine malarial model. | Malaria has been one of the most devastating tropical parasite infectious diseases popular around the world. Severe malaria is characterized by multiple organ dysfunctions, especially liver damage. However, the mechanisms of malarial liver injury remain to be better clarified. In this study, Kunming mice inoculated int... | ['Animals', 'Cytokines', 'Disease Models, Animal', 'Female', 'Galectins', 'Gene Expression Regulation', 'Hepatitis A Virus Cellular Receptor 2', 'Immunohistochemistry', 'Liver', 'Liver Diseases, Parasitic', 'Malaria', 'Mice', 'Parasitemia', 'Plasmodium berghei', 'RNA, Messenger', 'Real-Time Polymerase Chain Reaction', ... | 26,486,943 | [['B01.050'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['D12.776.503.307'], ['G05.308'], ['D12.776.395.550.479', 'D12.776.465.798', 'D12.776.543.550.437', 'D12.776.543.750.830.219'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512'... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
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