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Expression of girdin in human colorectal cancer and its association with tumor progression. | BACKGROUND: Girdin is crucial for cellular motility in cancer cell lines and for metastasis in a mouse model. Its expression has been demonstrated in a range of cancers by a few studies and was a prognostic factor in a subset of patients.OBJECTIVE: The aim of this study was to investigate the relationship of Girdin exp... | ['Aged', 'Biopsy', 'Colorectal Neoplasms', 'Disease Progression', 'Female', 'Humans', 'Immunohistochemistry', 'Liver Neoplasms', 'Lymphatic Metastasis', 'Male', 'Medical Records, Problem-Oriented', 'Microfilament Proteins', 'Middle Aged', 'Multivariate Analysis', 'Neoplasm Invasiveness', 'Neoplasm Staging', 'Prognosis'... | 23,222,280 | [['M01.060.116.100'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['C04.588.274.476.411.307', 'C06.301.371.411.307', 'C06.405.249.411.307', 'C06.405.469.158.356', 'C06.405.469.491.307', 'C06.405.469.860.180'], ['C23.550.2... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
Energy transfers from photosystem II to photosystem I in Cryptomonas rufescens (Cryptophyceae). | In Cryptomonas rufescens (Cryptophyceae), phycoerythrin located in the thylakoid lumen is the major accessory pigment. Oxygen action spectra prove phycoerythrin to be efficient in trapping light energy. The fluorescence excitation spectra at -196 degrees C obtained by the method of Butler and Kitajima (Butler, W.L. and... | ['Chlorophyll', 'Energy Transfer', 'Eukaryota', 'Light', 'Photosynthesis', 'Phycoerythrin', 'Spectrometry, Fluorescence', 'Spectrophotometry'] | 7,388,009 | [['D03.383.129.578.840.374', 'D03.633.400.909.374', 'D04.345.783.374'], ['G01.154.240', 'G02.111.255', 'G02.216'], ['B01'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['G02.111.158.937', 'G02.111.669.700', 'G02.740.921', 'G03.191.937', 'G03.493.700', 'G03.800.700', 'G15.568'], ['D05.5... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Hydroxyapatite chromatography of phage-display virions. | Hydroxyapatite column chromatography can be used to purify filamentous bacteriophage--the phage most commonly used for phage display. Virions that have been partially purified from culture supernatant by two cycles of precipitation in 2% polyethylene glycol are adsorbed onto the matrix at a density of at least 7.6 x 10... | ['Bacteriophages', 'Blotting, Western', 'Chromatography', 'Durapatite', 'Virion'] | 16,382,907 | [['B04.123'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['E05.196.181'], ['D01.029.260.700.675.374.075.025.300.150', 'D01.146.360.050.300.200', 'D01.578.122.477.300', 'D01.695.625.675.650.075.025.300.150'], ['A21.249']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Hepatocellular carcinoma immunopathogenesis: clinical evidence for global T cell defects and an immunomodulatory role for soluble CD25 (sCD25). | BACKGROUND: The mechanisms involved in hepatocellular carcinoma (HCC) establishing an immunologically tolerogenic tumor environment remain poorly characterized.AIMS: This study evaluates effector T cell responses and soluble IL-2 receptor alpha chains (sCD25) in relation to HCC stage/survival and characterizes the impa... | ['Adult', 'Aged', 'Aged, 80 and over', 'Biomarkers, Tumor', 'Carcinoma, Hepatocellular', 'Cell Proliferation', 'Enzyme-Linked Immunosorbent Assay', 'Female', 'Flow Cytometry', 'Humans', 'Immunity, Cellular', 'Interleukin-2 Receptor alpha Subunit', 'Liver Neoplasms', 'Male', 'Middle Aged', 'T-Lymphocytes', 'Tumor Cells,... | 19,714,465 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D23.101.140'], ['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['G04.161.750', 'G07.345.249.410.750'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Anipamil prevents intimal thickening in the aorta of hypertensive rabbits through changes in smooth muscle cell phenotype. | The aim of this study was to evaluate the effect of anipamil, a phenyalkylamine-derived Ca(2+)-antagonist, on aortic intimal thickening and smooth muscle cell (SMC) phenotype in 2K-1C hypertensive rabbits. Monoclonal antimyosin antibodies [SM-E7, NM-G2, and NM-F6, which respectively, recognize smooth muscle (SM), A-typ... | ['Animals', 'Aorta, Thoracic', 'Blood Pressure', 'Calcium Channel Blockers', 'Cell Differentiation', 'Culture Techniques', 'Fluorescent Antibody Technique, Direct', 'Hypertension', 'Male', 'Muscle, Smooth, Vascular', 'Phenotype', 'Propylamines', 'Rabbits'] | 8,806,982 | [['B01.050'], ['A07.015.114.056.372'], ['E01.370.600.875.249', 'G09.330.380.076'], ['D27.505.519.562.249', 'D27.505.696.260.500', 'D27.505.954.411.192'], ['G04.152'], ['E05.481.500'], ['E01.370.225.500.607.512.240.300', 'E01.370.225.750.551.512.240.300', 'E05.200.500.607.512.240.300', 'E05.200.750.551.512.240.300', 'E0... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Prospective assessment of the gastroesophageal microbiome in VLBW neonates. | BACKGROUND: The distal GI microbiota of hospitalized preterm neonates has been established to be unique from that of healthy full-term infants; the proximal GI, more specifically gastroesophageal colonization has not been systematically addressed. We prospectively evaluated early colonization of gastroesophageal portio... | ['DNA, Bacterial', 'Esophagus', 'Female', 'Humans', 'Infant, Newborn', 'Infant, Premature', 'Infant, Very Low Birth Weight', 'Intensive Care Units, Neonatal', 'Male', 'Metagenome', 'Phylogeny', 'Polymerase Chain Reaction', 'Prospective Studies', 'RNA, Ribosomal, 16S', 'Stomach'] | 23,560,555 | [['D13.444.308.212'], ['A03.556.875.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['M01.060.703.520.520'], ['M01.060.703.520.460.600'], ['N02.278.388.493.390.380'], ['G05.360.340.550'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['E05.393.620.500'], ['E05.318.372.500.750.625', 'N05.715.36... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Named Groups [M]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
X-ray emission analysis of human plasma by proton excitation of thick samples in air. | Thick plasma samples have been irradiated in air by 2.3 MeV protons for trace elemental analysis by proton-induced X-ray emission spectroscopy. Accurate calibration curves were obtained for Fe, Zn and Sr and detection limits in dry plasma were estimated to be 0.08 PPM for Fe, 0.065 PPM for Zn and 0.12 PPM for Sr. Low t... | ['Air', 'Humans', 'In Vitro Techniques', 'Iron', 'Protons', 'Specimen Handling', 'Spectrometry, X-Ray Emission', 'Strontium', 'Trace Elements', 'Zinc'] | 472,008 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Ventricular arrhythmia risk after subarachnoid hemorrhage. | INTRODUCTION: Cardiac morbidity and mortality after aneurysmal subarachnoid hemorrhage (SAH) are attributable to myocardial injury, decreased ventricular function, and ventricular arrhythmia (VA). Our objective was to test the relationships between QTc prolongation, VA, and survival after SAH.METHODS: In 200 subjects w... | ['Adult', 'Age Factors', 'Aged', 'Cohort Studies', 'Electrocardiography, Ambulatory', 'Female', 'Humans', 'Long QT Syndrome', 'Male', 'Middle Aged', 'Risk Factors', 'Severity of Illness Index', 'Stroke Volume', 'Subarachnoid Hemorrhage', 'Survival Rate'] | 19,184,553 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E01.370.370.380.240.230', 'E01.370.405.240.230', 'E01.370.520.500.230'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.280.067.565', 'C14.280.123.625',... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Measles mortality. Analysis of the primary cause of death. | Four hundred fifty-four death certificates showing measles as the cause of death were analyzed. These represented 35.4% of the recorded deaths due to measles from 1964 through 1971. Respiratory or neurologic complications of measles or both were noted as the primary cause of death on nearly 90% of the certificates revi... | ['Adolescent', 'Age Factors', 'Child', 'Child, Preschool', 'Death Certificates', 'Down Syndrome', 'Encephalitis', 'Female', 'Humans', 'Infant', 'Male', 'Measles', 'Pneumonia', 'Retrospective Studies'] | 123,705 | [['M01.060.057'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.406'], ['M01.060.406.448'], ['E05.318.308.940.350', 'L01.399.250.900.350', 'N04.452.859.264', 'N05.715.360.300.715.315', 'N06.850.520.308.940.350'], ['C10.597.606.360.220', 'C16.131.077.327', 'C16.131.260.260', 'C16.320.180.260'], ['C10.228.140.430'], ... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Hepatitis C virus infection in volunteer blood donors in Taiwan. Evaluation by hepatitis C antibody assays and the polymerase chain reaction. | A total of 2671 plasma samples that were selected from 22,500 volunteer blood donors in Taiwan were studied for hepatitis C virus (HCV) infection. The donors were stratified into three groups by serum alanine aminotransferase (ALT) levels. Of the donors, 20,768 (92.3%) had an ALT level less than 30 IU/L (group 1), 1080... | ['Antigens, Viral', 'Base Sequence', 'Blood Donors', 'Enzyme-Linked Immunosorbent Assay', 'Hepacivirus', 'Hepatitis Antibodies', 'Hepatitis C', 'Hepatitis C Antibodies', 'Humans', 'Molecular Sequence Data', 'Polymerase Chain Reaction', 'Predictive Value of Tests', 'Seroepidemiologic Studies', 'Taiwan', 'Viral Nonstruct... | 8,381,269 | [['D23.050.327'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['M01.898.313'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['B04.450.380', 'B04.820.578.344.475'], ['D12.776.124.486.485.114.254.450', 'D12.776.124.790.651.114.254.450'... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
Ookinete rates in Afrotropical anopheline mosquitoes as a measure of human malaria infectiousness. | Anopheles gambiae s.1. and An. funestus were sampled for Plasmodium spp. ookinetes in two P. falciparum-endemic sites in western Kenya. Since the ookinete is a transitional stage of short duration, occurring after fertilization and before oocyst development, only females in the half-gravid and gravid stages of blood di... | ['Animals', 'Anopheles', 'Feeding Behavior', 'Female', 'Humans', 'Insect Vectors', 'Kenya', 'Malaria', 'Plasmodium'] | 1,636,882 | [['B01.050'], ['B01.050.500.131.617.720.500.500.750.712.500.875.120'], ['F01.145.113.547', 'F01.145.407', 'G07.203.650.353'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N06.850.335.188.100.500', 'N06.850.520.203.375.100.500'], ['Z01.058.290.120.400'], ['C01.610.752.530', 'C01.920.875'], ['B01.043.075.380.611']] | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Geographicals [Z]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Alternative oxidase rescues mitochondria-mediated dopaminergic cell loss in Drosophila. | Mitochondrial dysfunction is commonly observed in degenerative disorders, including Alzheimer's and Parkinson's disease that are characterized by the progressive and selective loss of neuronal subpopulations. It is currently unclear, however, whether mitochondrial dysfunction is primary or secondary to other pathogenic... | ['Adenosine Triphosphate', 'Aging', 'Animals', 'Blotting, Western', 'Cytoskeletal Proteins', 'DNA, Mitochondrial', 'DNA-Directed DNA Polymerase', 'Dopaminergic Neurons', 'Drosophila Proteins', 'Drosophila melanogaster', 'Electron Transport', 'Electron Transport Complex I', 'GTP-Binding Proteins', 'Humans', 'Mitochondri... | 22,398,207 | [['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['G07.345.124'], ['B01.050'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['D12.776.220'], ['D13.444.308.283.225'], ['D08.811.913.696.445.308.300'], ['A08.675.278', 'A11.671.270'], ['... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Isolated juvenile xanthogranuloma in the larynx of a three-year-old child. | Juvenile xanthogranuloma (JXG) is a benign manifestation of non-Langerhans cell histiocytosis characterized by yellowish cutaneous nodules. Its occurrence in the larynx is very rare, but laryngeal JXG may cause severe respiratory distress. We report a patient with isolated laryngeal JXG treated by laryngomicrosurgery, ... | ['Child, Preschool', 'Female', 'Glottis', 'Histiocytosis, Langerhans-Cell', 'Humans', 'Immunohistochemistry', 'Larynx', 'Prognosis', 'Respiratory Tract Diseases', 'Treatment Outcome', 'Xanthogranuloma, Juvenile'] | 23,801,051 | [['M01.060.406.448'], ['A04.329.364'], ['C08.381.483.375', 'C15.604.250.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512', 'H01.158.201.344.512', 'H01.158.201.486.512', 'H0... | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Late-onset muscle weakness in partial phosphofructokinase deficiency: a unique myopathy with vacuoles, abnormal mitochondria, and absence of the common exon 5/intron 5 junction point mutation. | Three patients (ages 51, 59, and 79) from two generations of an Ashkenazi Jewish family had partial (33% activity) phosphofructokinase (PFK) deficiency that presented with fixed muscle weakness after the age of 50 years. MR spectroscopy revealed accumulation of phosphomonoesters during exercise. Muscle biopsy showed a ... | ['Adult', 'Age of Onset', 'Aged', 'Aged, 80 and over', 'Base Sequence', 'Biopsy', 'DNA Primers', 'Electron Transport Complex IV', 'Europe', 'Exons', 'Glycogen Storage Disease Type VII', 'Humans', 'Introns', 'Jews', 'Middle Aged', 'Mitochondria, Muscle', 'Molecular Sequence Data', 'Muscle Fibers, Fast-Twitch', 'Muscle, ... | 8,628,478 | [['M01.060.116'], ['N05.715.350.075.100', 'N06.850.490.250.100'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['D13.... | ['Named Groups [M]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
Morality and politics: Comparing alternate theories. | Debates about the American "culture wars" have led scholars to develop several theories relating morality to political attitudes and behaviors. However, researchers have not adequately compared these theories, nor have they examined the overall contribution of morality to explaining political variation. This study uses... | ['Attitude', 'Culture', 'Dissent and Disputes', 'Humans', 'Morals', 'Politics', 'Social Values', 'United States'] | 26,188,452 | [['F01.100'], ['I01.076.201.450', 'I01.880.853.100'], ['F01.829.401.094', 'F02.463.785.373.476'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.500', 'K01.752.566'], ['I01.738'], ['F01.829.873'], ['Z01.107.567.875']] | ['Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Humanities [K]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 |
Early life stress increases testosterone and corticosterone and alters stress physiology in zebra finches. | Early life stress has enduring effects on behavior and physiology. However, the effects on hormones and stress physiology remain poorly understood. In the present study, parents of zebra finches of both sexes were exposed to an increased foraging paradigm from 3 to 33days post hatching. Plasma and brains were collected... | ['Animals', 'Animals, Newborn', 'Brain', 'Corticosterone', 'Corticotropin-Releasing Hormone', 'Estradiol', 'Female', 'Finches', 'Glucocorticoids', 'Hypothalamus', 'Male', 'Receptors, Glucocorticoid', 'Stress, Physiological', 'Stress, Psychological', 'Testosterone'] | 28,782,547 | [['B01.050'], ['B01.050.050.282'], ['A08.186.211'], ['D04.210.500.745.745.654.237', 'D06.472.040.585.353.237'], ['D06.472.699.327.740.140', 'D12.644.400.400.740.140', 'D12.644.548.365.740.140', 'D12.776.631.650.405.740.140'], ['D04.210.500.365.415.248', 'D06.472.334.851.437.500'], ['B01.050.150.900.248.620.750.250'], [... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Development of a Breastfeeding Support Scale for Couples. | The aim of this study was to develop a Breastfeeding Support Scale for Couples (BSSC) and to examine its reliability and validity. The BSSC was designed to evaluate current state of mutual support necessary for breastfeeding from the perspective of wife as support recipient, and husband as support provider. Subjects we... | ['Breast Feeding', 'Female', 'Humans', 'Infant', 'Interpersonal Relations', 'Japan', 'Male', 'Reproducibility of Results', 'Social Support', 'Spouses'] | 27,040,061 | [['F01.145.407.199', 'G07.203.650.195', 'G07.203.650.220.500.500', 'G07.203.650.353.199'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['F01.829.401'], ['Z01.252.474.463', 'Z01.639.595'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['I01.880.853.500.600'], ['F... | ['Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Named Groups [M]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Probabilistic muscle characterization using QEMG: application to neuropathic muscle. | Clinicians who use electromyographic (EMG) signals to help determine the presence or absence of abnormality in a muscle often, with varying degrees of success, evaluate sets of motor unit potentials (MUPs) qualitatively and/or quantitatively to characterize the muscle in a clinically meaningful way. The resulting muscl... | ['Action Potentials', 'Adult', 'Amyotrophic Lateral Sclerosis', 'Bayes Theorem', 'Charcot-Marie-Tooth Disease', 'Electromyography', 'Humans', 'Isometric Contraction', 'Middle Aged', 'Models, Statistical', 'Motor Neurons', 'Muscle, Skeletal', 'Reproducibility of Results', 'Sensitivity and Specificity'] | 19,768,760 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['M01.060.116'], ['C10.228.854.139', 'C10.574.562.250', 'C10.574.950.050', 'C10.668.467.250', 'C18.452.845.800.050'], ['E05.318.740.600.200', 'N05.715.360.750.625.150', 'N06.850.520.830.600.200'], ['C10.500.300.200', 'C10.574.500.495.200', 'C10.668.829.800.300.200... | ['Phenomena and Processes [G]', 'Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Kinetics of in vivo bone deposition by bone marrow stromal cells into porous calcium phosphate scaffolds: an X-ray computed microtomography study. | In a typical bone tissue engineering application, osteogenic cells are harvested and seeded on a three-dimensional (3D) synthetic scaffold that acts as guide and stimulus for tissue growth, creating a tissue engineering construct or living biocomposite. Despite the large number of performed experiments in different lab... | ['Animals', 'Bone Marrow Cells', 'Calcium Phosphates', 'Kinetics', 'Mice', 'Mice, Nude', 'Osteogenesis', 'Porosity', 'Sheep', 'Stromal Cells', 'Tissue Engineering', 'Tomography, X-Ray Computed'] | 17,518,681 | [['B01.050'], ['A11.148', 'A15.378.316'], ['D01.029.260.700.675.374.075', 'D01.146.360', 'D01.695.625.675.650.075'], ['G01.374.661', 'G02.111.490'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.150.900.649.313.992.635.505.500.550.500'], ['G07.345.500.325.377.625.050.500.729', 'G11.427.578.050.500.729'], ['G01... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Transcription factor expression in the developing human fetal endocrine pancreas. | AIMS/HYPOTHESIS: Morphological changes that occur during pancreatic endocrine cell differentiation have been shown in rodent systems to be dependent on sequential alterations in transcription factor expression. However, similar data for humans have been limited. The aim of the present study was to provide a connection ... | ['Basic Helix-Loop-Helix Transcription Factors', 'Biomarkers', 'Down-Regulation', 'Gene Expression Profiling', 'Gene Expression Regulation, Developmental', 'Gestational Age', 'Hepatocyte Nuclear Factor 1-alpha', 'Hepatocyte Nuclear Factor 3-beta', 'Hepatocyte Nuclear Factor 6', 'Homeodomain Proteins', 'Humans', 'Nerve ... | 18,491,072 | [['D12.776.260.103', 'D12.776.930.125'], ['D23.101'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['E05.393.332'], ['G05.308.310'], ['G07.345.500.325.235.968', 'G08.686.320'], ['D12.776.260.262.500.500', 'D12.776.260.400.218.500', 'D12.776.660.352.500.500', 'D12.776.930.318.500.500'], ['D12.776.260.262.875', 'D1... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
High prevalence of prehypertension is associated with the increased body mass index in community-dwelling Japanese. | Hypertension and obesity are likely the most common disease in Japan. It has been reported that subjects with prehypertension (systolic blood pressure [SBP] 120-139 mmHg and/or diastolic blood pressure [DBP] 80-89 mmHg) have also an increased risk of cardiovascular disease; however, only limited data are available on t... | ['Adult', 'Aged', 'Aged, 80 and over', 'Blood Pressure', 'Body Mass Index', 'Disease Susceptibility', 'Female', 'Humans', 'Hypertension', 'Japan', 'Male', 'Middle Aged', 'Odds Ratio', 'Prevalence', 'Residence Characteristics', 'Young Adult'] | 19,060,450 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['C23.550.291.687', 'G07.100.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['Z01.252.474.46... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Late presentations of congenital diaphragmatic hernia. | The occurrence of congenital diaphragmatic hernia in adults is rare and misleading even to experienced clinicians. In contrast to neonatal diaphragmatic hernias, most of the adult patients present with vague gastrointestinal and respiratory symptoms mimicking other diseases. Hence high index of suspicion is required. W... | ['Adult', 'Diagnosis, Differential', 'Female', 'Hernia, Diaphragmatic', 'Hernias, Diaphragmatic, Congenital', 'Humans', 'Male', 'Radiography'] | 22,929,853 | [['M01.060.116'], ['E01.171'], ['C23.300.707.960.500'], ['C16.131.433', 'C23.300.707.960.500.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.700']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Captopril treatment reverses erectile dysfunction in male stroke prone spontaneously hypertensive rats. | The involvement of antihypertensive therapy in the pathology of hypertension associated male erectile dysfunction is unclear. Stroke prone spontaneously hypertensive rats (SHRSP) were treated chronically with the angiotensin converting enzyme (ACE) inhibitor captopril or placebo, normotensive rats served as controls. M... | ['Angiotensin-Converting Enzyme Inhibitors', 'Animals', 'Blood Pressure', 'Captopril', 'Erectile Dysfunction', 'Genetic Predisposition to Disease', 'Hypertension', 'Male', 'Penile Erection', 'Rats', 'Rats, Inbred SHR', 'Stroke'] | 12,494,284 | [['D27.505.519.389.745.085'], ['B01.050'], ['E01.370.600.875.249', 'G09.330.380.076'], ['D12.125.072.401.623.270'], ['C12.294.644.486', 'F03.835.400'], ['C23.550.291.687.500', 'G05.380.355'], ['C14.907.489'], ['G08.686.784.717'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760.300', 'B01.050.150.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A new and simple method for evaluating masticatory function using newly developed artificial test food. | The aim of this study was to develop an objective evaluation system for the masticatory function. This system used paraffin wax cubes as a test food, which had six red- and green-coloured layers so that each of the six surfaces showed a pseudo-checkered pattern. A total of 100 paraffin cubes were chewed by 37 subjects ... | ['Adult', 'Discriminant Analysis', 'Female', 'Humans', 'Image Processing, Computer-Assisted', 'Male', 'Mastication', 'Paraffin', 'Photography', 'Waxes'] | 12,485,386 | [['M01.060.116'], ['E05.318.740.350', 'N05.715.360.750.325', 'N06.850.520.830.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['G07.203.650.283.500', 'G10.261.330.500'], ['D02.455.612'], ['E01.370.350.600', 'E05.712'], ['D10.945']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Information Science [L]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
[Research on root fracture resistance after root canal filling]. | OBJECTIVE: To compare the fracture resistance of roots filled with three different root canal filling techniques.METHODS: Forty extracted single-rooted permanent teeth were instrumented and randomly divided into four groups. Three experimental groups were filled with lateral compaction technique, vertical compaction te... | ['Dental Pulp Cavity', 'Dental Stress Analysis', 'Gutta-Percha', 'Humans', 'Root Canal Filling Materials', 'Root Canal Obturation', 'Tooth Fractures', 'Tooth Root'] | 23,841,290 | [['A14.549.167.900.265'], ['E06.308'], ['D20.215.721.061', 'D25.339.859.495', 'D25.720.327.840.119', 'J01.637.051.339.859.495'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D25.339.859', 'J01.637.051.339.859'], ['E06.397.778.778'], ['C07.793.850.750', 'C26.900.750'], ['A14.549.167.900.750']] | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
[The function of the digestive processes in the stomach and small intestine in complicated peptic ulcer]. | On the basis of investigations designed to study the condition of intragastric proteolysis and membrane digestion in the small intestine in 148 patients it has been found out that peptic ulcer is accompanied by enhancement of digestive processes in the stomach and by decrease thereof in the small intestine. With the de... | ['Adult', 'Aged', 'Chronic Disease', 'Digestion', 'Duodenal Ulcer', 'Humans', 'Hydrogen-Ion Concentration', 'Intestine, Small', 'Middle Aged', 'Peptic Ulcer Hemorrhage', 'Peptic Ulcer Perforation', 'Peptide Hydrolases', 'Pyloric Stenosis', 'Stomach'] | 9,844,870 | [['M01.060.116'], ['M01.060.116.100'], ['C23.550.291.500'], ['G07.203.650.250', 'G10.261.190'], ['C06.405.469.275.800.348', 'C06.405.748.586.349'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.300'], ['A03.556.124.684'], ['M01.060.116.630'], ['C06.405.227.700', 'C23.550.414.788.700'], ['C06.405.469.275.800.69... | ['Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Application of the principal component analysis (PCA) to the ecological study of an artificial environment: the tunny-fishing net of Camogli (Ligurian Sea). | The management of the marine environment and resource exploitation depend on the knowledge of both water conditions and ecological relationships between organisms. In the framework of fishing problems, an adequate food availability is important in order to allow maintaining and growth of fish stocks. The tunny-fishing ... | ['Animals', 'Ecology', 'Environment', 'Fishes', 'Seasons'] | 11,449,824 | [['B01.050'], ['H01.158.273.248', 'H01.277.249'], ['G16.500.275', 'N06.230'], ['B01.050.150.900.493'], ['G01.910.645.661', 'G16.500.275.071.590', 'N06.230.300.100.250.525']] | ['Organisms [B]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
[Changes in the content of neuromediator amino acids in the brain of mice with a convulsive syndrome induced by the hyperactivation of CNS cholinergic structures]. | Methods of thin-layer chromatography with the following elution and photometry were used to determine the amount of taurin, glycin and glutamate in mouse brain 20 and 60 min after injections of arecolin (10 mg/kg), nicotin (9 mg/kg), fluorostigmin (3 mg/kg) and picrotoxin (8 mg/kg). It was determined that seizures indu... | ['Amino Acids', 'Animals', 'Brain', 'Brain Chemistry', 'Male', 'Mice', 'Neurotransmitter Agents', 'Receptors, Cholinergic', 'Seizures', 'Syndrome', 'Time Factors'] | 1,973,059 | [['D12.125'], ['B01.050'], ['A08.186.211'], ['G02.111.150', 'G03.185'], ['B01.050.150.900.649.313.992.635.505.500'], ['D27.505.519.625', 'D27.505.696.577'], ['D12.776.543.750.720.360'], ['C10.597.742', 'C23.888.592.742'], ['C23.550.288.500'], ['G01.910.857']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
In vitro properties of antimicrobial bromotyrosine alkaloids. | A bromotyrosine alkaloid family of antimicrobial agents was synthesized using the known structure of a natural inhibitor of the mycobacterial mycothiol S-conjugate amidase (MCA) as a template. This series of compounds represents a novel class of anti-infective agents against Gram-positive pathogens, including mycobacte... | ['Alkaloids', 'Anti-Bacterial Agents', 'Bacteria', 'Cell Line', 'Humans', 'Macrophages', 'Models, Chemical', 'Molecular Structure', 'Monocytes', 'Tyrosine'] | 16,533,988 | [['D03.132'], ['D27.505.954.122.085'], ['B03'], ['A11.251.210'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.329.372', 'A11.627.482', 'A11.733.397', 'A15.382.670.522', 'A15.382.680.397'], ['E05.599.495'], ['G02.111.570', 'G02.466'], ['A11.118.637.555.652', 'A11.148.580', 'A11.627.624', 'A11.733.547', 'A15.14... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
DNA fingerprinting of Pasteurella multocida recovered from avian sources. | Repetitive sequence-based PCR (rep-PCR) and amplified fragment length polymorphism (AFLP) were used to characterize a sample of 43 field isolates and 4 attenuated vaccine strains of Pasteurella multocida recovered from multiple avian species. Both rep-PCR and AFLP assays were rapid and reproducible, with high indices o... | ['Animals', 'Bacterial Typing Techniques', 'Bird Diseases', 'Birds', 'Chickens', 'DNA Fingerprinting', 'DNA, Bacterial', 'Disease Outbreaks', 'Pasteurella Infections', 'Pasteurella multocida', 'Polymerase Chain Reaction', 'Polymorphism, Restriction Fragment Length', 'Poultry Diseases', 'Reproducibility of Results', 'So... | 12,149,370 | [['B01.050'], ['E01.370.225.875.150.125', 'E05.200.875.150.125'], ['C22.131'], ['B01.050.150.900.248'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['E05.318.740.225.500.500', 'E05.393.290', 'I01.198.780.937.375', 'N04.452.910.099.750'], ['D13.444.308.212'], ['N06.850.290'], ['C01.150.252.400.700.66... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 |
Receptors for the liver synthesized growth factors IGF-1 and HGF/SF in uveal melanoma: intercorrelation and prognostic implications. | PURPOSE: Uveal melanoma disseminates preferentially to the liver. The mechanism for this homing is largely unknown, but growth factors synthesized in the liver may be involved. The present study was undertaken to investigate the possible relationship between cell surface receptors for two such growth factors: the c-Met... | ['Adult', 'Aged', 'Aged, 80 and over', 'Biomarkers, Tumor', 'Female', 'Humans', 'Immunoenzyme Techniques', 'Liver', 'Male', 'Melanoma', 'Middle Aged', 'Neoplasm Proteins', 'Prognosis', 'Proto-Oncogene Proteins c-met', 'Receptor, IGF Type 1', 'Survival Rate', 'Uveal Neoplasms'] | 16,303,922 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D23.101.140'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.478.566.350', 'E05.478.583.400', 'E05.601.470.350'], ['A03.620'], ['C04.557.465.625.650.510', 'C04.557.580.625.650.510', 'C04.557.665.510'], ['M01.060.116.630'], ['D12.776.624'], ['E01... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Comparison of static airway pressures during total liquid ventilation while applying different expiratory modes and time patterns. | To compare pump driven (active) and gravity-siphon (passive) expiration modes during perfluorocarbon total liquid ventilation (TLV), a liquid ventilator was developed capable of providing either expiration mode. In a prospective, controlled laboratory study, 90 rabbits (3.2 +/- 0.1 kg) were anesthetized, tracheotomized... | ['Animals', 'Biomedical Engineering', 'Female', 'Fluorocarbons', 'Liquid Ventilation', 'Male', 'Prospective Studies', 'Rabbits', 'Respiratory Mechanics', 'Time Factors'] | 14,763,494 | [['B01.050'], ['H02.070', 'J01.293.140'], ['D02.455.526.510.435'], ['E02.041.625.525', 'E02.880.820.525'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['B01.050.150.900.649.313.968.700'], ['G09.772.705.700'], ['G01.910.857']] | ['Organisms [B]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 |
Antimicrobial susceptibility and mechanism of quinolone resistance in Campylobacter jejuni strains isolated from diarrheal patients in a hospital in Tokyo. | We determined the minimum inhibitory concentrations of six types of antimicrobial agents for 523 strains of Campylobacter jejuni that were isolated from diarrheal patients in a general hospital in Tokyo during the period between 2003 and 2005. It was revealed that 20.2%, 22.9%, 6.7%, and 0.6% of all the C. jejuni strai... | ['Amino Acid Substitution', 'Anti-Bacterial Agents', 'Campylobacter Infections', 'Campylobacter jejuni', 'DNA Gyrase', 'DNA Mutational Analysis', 'Diarrhea', 'Drug Resistance, Bacterial', 'Electrophoresis, Gel, Pulsed-Field', 'Feces', 'Humans', 'Microbial Sensitivity Tests', 'Quinolones', 'Tokyo'] | 18,936,886 | [['E05.393.420.601.035', 'G05.558.109'], ['D27.505.954.122.085'], ['C01.150.252.400.177'], ['B03.440.180.425', 'B03.660.150.235.250.500.375'], ['D08.811.399.403.741.149', 'D12.776.097.237'], ['E05.393.760.700.300'], ['C23.888.821.214'], ['G06.099.225', 'G06.225.347', 'G07.690.773.984.269.347'], ['E05.196.401.220', 'E05... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Geographicals [Z]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
[Canine teeth impacted in the palate--case report]. | Maxillary canines have the longest period of development, the deepest area of formation and the most difficult path of all teeth. The maxillary canines are the most likely to remain unerupted or impacted. The maxillary permanent canine is considered important by virtue of its place in the scheme of functional occlusion... | ['Adolescent', 'Adult', 'Cuspid', 'Female', 'Humans', 'Orthodontic Wires', 'Palate, Hard', 'Radiography, Panoramic', 'Tooth Eruption, Ectopic', 'Tooth, Impacted', 'Treatment Outcome'] | 22,276,481 | [['M01.060.057'], ['M01.060.116'], ['A14.549.167.860.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E06.658.453.684'], ['A02.835.232.781.324.502.660', 'A14.521.658.660', 'A14.549.617.660'], ['E01.370.350.700.720.750', 'E06.342.764.750'], ['C07.793.790'], ['C07.793.905'], ['E01.789.800', 'N04.761.559.590.800'... | ['Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Target range maximum of cyclosporine blood concentration two hours post dose in stable liver transplant patients. | Recently, single blood level measurement 2 hours after cyclosporine administration (C2) is taken as a more sensitive indicator of drug exposure in de novo transplant recipients than trough levels (C0). However, few studies focused on the determination of the C2 target range maximum and its associated adverse events in ... | ['Adult', 'Aged', 'Cyclosporine', 'Dose-Response Relationship, Drug', 'Drug Monitoring', 'Female', 'Humans', 'Immunosuppressive Agents', 'Liver Transplantation', 'Male', 'Middle Aged', 'Prospective Studies', 'Time Factors'] | 16,720,277 | [['M01.060.116'], ['M01.060.116.100'], ['D04.345.566.235.300', 'D12.644.641.235.300'], ['G07.690.773.875', 'G07.690.936.500'], ['E01.370.520.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.477.656'], ['E02.095.147.725.490', 'E04.210.650', 'E04.936.450.490', 'E04.936.580.490'], ['M01.060.116.630'],... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
FoxP3+ T regulatory cells and immunomodulation after Schistosoma mansoni egg antigen immunization in experimental model of inflammatory bowel disease. | To assess the effect of Schistosoma mansoni egg antigen immunization on the immunomodulation in dextran sodium sulfate (DSS) induced colitis as an experimental model of IBD in comparison to non immunization and healthy control. The study was performed on 180 mice; 25 healthy control, 15 to identify the inflammatory pea... | ['Animals', 'Antigens, Helminth', 'Cytokines', 'Dextran Sulfate', 'Enzyme-Linked Immunosorbent Assay', 'Female', 'Forkhead Transcription Factors', 'Immunization', 'Immunohistochemistry', 'Immunomodulation', 'Inflammatory Bowel Diseases', 'Lymphocyte Count', 'Mice', 'Ovum', 'Peroxidase', 'Schistosoma mansoni', 'Severity... | 25,766,778 | [['B01.050'], ['D23.050.223'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['D09.698.365.272.300'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['D12.776.260.950.249', 'D12.776.930.977.249'], ['E02.095.465.425.400', 'E05.478.550', 'N02.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Hepatocyte sortilin 1 knockout and treatment with a sortilin 1 inhibitor reduced plasma cholesterol in Western diet-fed mice. | Sortilin 1 (Sort1) is a member of the Vps10p domain intracellular trafficking receptor family. Genetic variations of the SORT1 gene are strongly associated with plasma cholesterol levels in humans. Recent studies have linked Sort1 to regulation of cholesterol metabolism in hepatocytes and pro-inflammatory response in m... | ['Adaptor Proteins, Vesicular Transport', 'Animals', 'Blood Glucose', 'Cholesterol', 'Cytokines', 'Diet, Western', 'Fasting', 'Fatty Liver', 'Gene Expression Regulation', 'Gene Knockout Techniques', 'Hepatocytes', 'Macrophages', 'Mice', 'Mice, Inbred C57BL'] | 30,670,473 | [['D12.776.543.990.150'], ['B01.050'], ['D09.947.875.359.448.500'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['G07.203.650.240.310'], ['F01.145.407.400', 'G07.203.650.240.587', 'G07.203.650.353.400'], ['C06.552.241'], ['G05.308'], ... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The antinociceptive and antihyperalgesic effect of tapentadol is partially retained in OPRM1 (ì-opioid receptor) knockout mice. | Activation of the ì-opioid receptor (MOR) and noradrenaline reuptake inhibition (NRI) are well recognized as analgesic principles in acute and chronic pain indications. The novel analgesic tapentadol combines MOR agonism and NRI in a single molecule. The present study used OPRM1 (MOR) knockout (KO) mice to determine th... | ['Analgesics, Opioid', 'Animals', 'Diabetes Mellitus, Experimental', 'Diabetic Neuropathies', 'Mice', 'Mice, Knockout', 'Neuralgia', 'Phenols', 'Receptors, Opioid, mu', 'Tapentadol'] | 21,232,580 | [['D27.505.696.277.600.500', 'D27.505.696.663.850.014.760.500', 'D27.505.954.427.040.550.500', 'D27.505.954.427.210.600.500'], ['B01.050'], ['C18.452.394.750.074', 'C19.246.240', 'E05.598.500.374'], ['C10.668.829.300', 'C19.246.099.937'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.136.500.500', 'B01.050... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Upregulation of hsa_circ_0136666 contributes to breast cancer progression by sponging miR-1299 and targeting CDK6. | Circular RNAs (circRNAs) can participate in multiple cancers, including breast cancer. Increasing circRNAs are recognized in various cancers because of the high-throughput sequencing. However, the potential physiological effect of hsa_circ_0136666 in breast cancer progression is unknown. In our study, the biological ro... | ["3' Untranslated Regions", 'Breast Neoplasms', 'Cell Line, Tumor', 'Cell Movement', 'Cell Proliferation', 'Cyclin-Dependent Kinase 6', 'Disease Progression', 'Female', 'Gene Expression Regulation, Neoplastic', 'Humans', 'MCF-7 Cells', 'MicroRNAs', 'RNA, Circular', 'Up-Regulation'] | 30,993,801 | [['D13.444.735.544.875.880', 'D13.444.735.790.878.880', 'G05.360.340.024.220.880.880', 'G05.360.340.024.340.137.910.880'], ['C04.588.180', 'C17.800.090.500'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.198', 'G07.568.500.180'], ['G04.161.750', 'G07.345.249.410.750'], ['D08.811.913.696.620.682.700.646.500.937', 'D12.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mannose 6-phosphate/insulin-like growth factor II receptor is a death receptor for granzyme B during cytotoxic T cell-induced apoptosis. | The serine proteinase granzyme B is crucial for the rapid induction of target cell apoptosis by cytotoxic T cells. Granzyme B was recently demonstrated to enter cells in a perforin-independent manner, thus predicting the existence of a cell surface receptor(s). We now present evidence that this receptor is the cation-i... | ['Animals', 'Apoptosis', 'Binding, Competitive', 'Cell Transplantation', 'Cells, Cultured', 'Cytotoxicity, Immunologic', 'Endocytosis', 'Flow Cytometry', 'Graft Rejection', 'Granzymes', 'Humans', 'In Situ Nick-End Labeling', 'Jurkat Cells', 'Kidney', 'L Cells', 'Mannosephosphates', 'Mice', 'Mice, Inbred BALB C', 'Mice,... | 11,081,635 | [['B01.050'], ['G04.146.954.035'], ['E05.196.080', 'G02.111.084', 'G02.111.570.120.309'], ['E02.095.147.500', 'E04.936.225'], ['A11.251'], ['G12.287'], ['G04.417'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.200.500.386.350', 'E05.242.363.342', 'E05... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Radiology of ileal pouch-anal anastomosis: normal findings, examination pitfalls, and complications. | Ileal pouch-anal anastomosis (IPAA) is a procedure in which an ileal reservoir is constructed after total colectomy and anastomosed to the anus. IPAA is a well-established option for patients who require surgery for chronic ulcerative colitis or familial adenomatous polyposis. Although excellent functional results can ... | ['Adolescent', 'Adult', 'Barium Sulfate', 'Contrast Media', 'Female', 'Humans', 'Ileum', 'Male', 'Middle Aged', 'Postoperative Complications', 'Proctocolectomy, Restorative', 'Tomography, X-Ray Computed'] | 9,017,801 | [['M01.060.057'], ['M01.060.116'], ['D01.103.075', 'D01.875.800.800.850.075'], ['D27.505.259.500', 'D27.720.259'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A03.556.124.684.249', 'A03.556.249.124'], ['M01.060.116.630'], ['C23.550.767'], ['E04.210.219.620', 'E04.210.895.500'], ['E01.370.350.350.810', 'E01.370.3... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
cDNA cloning and bacterial expression of phospholipase A(2) inhibitor PLIalpha from the serum of the Chinese mamushi, Agkistrodon blomhoffii siniticus(1). | The cDNA encoding of a phospholipase A(2) inhibitor (PLIalpha) of the Chinese mamushi, Agkistrodon blomhoffii siniticus, was identified from a liver cDNA library by use of a probe prepared by polymerase chain reaction (PCR) on the basis of the amino acid sequence of PLIalpha. It encoded a polypeptide of 166 amino acid ... | ['Agkistrodon', 'Amino Acid Sequence', 'Animals', 'Base Sequence', 'Blood Proteins', 'Cloning, Molecular', 'DNA, Complementary', 'Gene Library', 'Molecular Sequence Data', 'Mutation', 'Phosphodiesterase Inhibitors', 'Phospholipases A', 'Reverse Transcriptase Polymerase Chain Reaction'] | 10,526,227 | [['B01.050.150.900.833.672.125.937.240.250'], ['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D12.776.124'], ['E05.393.220'], ['D13.444.308.497.220', 'D13.444.600.223.500', 'D27.720.470.530.600.223.260'], ['G05.360.325'], ['L01.453.245.667'], ['G05.3... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Antioxidant effect of propolis against exposure to chromium in Cyprinus carpio. | The aim of the present study was to investigate the ameliorative properties of propolis against the toxic effects of chromium (VI) by examining oxidative damage markers such as lipid peroxidation and the antioxidant defence system components in carp (Cyprinus carpio). The fish were exposed to sublethal concentrations o... | ['Animals', 'Antioxidants', 'Carps', 'Catalase', 'Chromium', 'Gills', 'Glutathione', 'Glutathione Peroxidase', 'Kidney', 'Lipid Peroxidation', 'Liver', 'Malondialdehyde', 'Oxidative Stress', 'Propolis', 'Spleen', 'Superoxide Dismutase', 'Water Pollutants, Chemical'] | 22,052,654 | [['B01.050'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['B01.050.150.900.493.200.244.248'], ['D08.811.682.732.332'], ['D01.268.556.175', 'D01.268.956.124', 'D01.552.544.175'], ['A13.421'], ['D12.644.456.448'], ['D08.811.682.732.500'], ['A05.810.453'], ['G02.111.515', 'G03.295.531.587'], ['A03.620'... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Duplex PCR to differentiate between Mycoplasma synoviae and Mycoplasma gallisepticum on the basis of conserved species-specific sequences of their hemagglutinin genes. | We developed a duplex PCR assay targeting the hemagglutinin multigene families, vlhA and pMGA, of Mycoplasma synoviae and Mycoplasma gallisepticum, respectively. The assay proved to be specific and sensitive enough to justify its use for the simultaneous detection of the two major avian mycoplasma species from field is... | ['Animals', 'Bacterial Proteins', 'Conserved Sequence', 'Hemagglutinins', 'Mycoplasma Infections', 'Mycoplasma gallisepticum', 'Mycoplasma synoviae', 'Polymerase Chain Reaction', 'Poultry Diseases', 'Sensitivity and Specificity', 'Species Specificity', 'Trachea'] | 15,695,715 | [['B01.050'], ['D12.776.097'], ['G02.111.570.580'], ['D27.505.696.477.136.377'], ['C01.150.252.400.610.610'], ['B03.440.860.580.553.553.345'], ['B03.440.860.580.553.553.770'], ['E05.393.620.500'], ['C22.131.728'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700', 'N05.715.360.750.725', 'N06.850.5... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Spatial competition with Lactococcus lactis in mixed-species continuous-flow biofilms inhibits Listeria monocytogenes growth. | Surfaces in industrial settings provide a home for resident biofilms that are likely to interact with the attachment, growth and survival of pathogens such as Listeria monocytogenes. Experimental results have indicated that L. monocytogenes cells were inhibited by the presence of a model resident flora (Lactococcus lac... | ['Antibiosis', 'Bacterial Load', 'Bacteriological Techniques', 'Biofilms', 'Culture Media', 'Humans', 'Lactococcus lactis', 'Listeria monocytogenes', 'Microscopy, Confocal'] | 22,043,862 | [['G06.550.050', 'G16.062'], ['E01.370.225.875.150.115', 'E01.370.225.875.220.115', 'E05.200.875.150.115', 'E05.200.875.220.115', 'G06.099.100'], ['E01.370.225.875.150', 'E05.200.875.150'], ['A20.593', 'G06.120'], ['D27.720.470.305', 'E07.206'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B03.353.750.737.500.400... | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Quantification of 1,5-anhydro-D-glucitol in urine by automated borate complex anion-exchange chromatography with an immobilized enzyme reactor. | HPLC using a borate form of a strongly anion-exchange resin column and an immobilized enzyme reactor for colorimetric detection was used to quantify urinary 1,5-anhydro-D-glucitol. Urine samples were introduced into the system every 7 min without any pretreatment, and after separation of interfering substances in the c... | ['Borates', 'Chromatography, Gas', 'Chromatography, High Pressure Liquid', 'Chromatography, Ion Exchange', 'Deoxyglucose', 'Enzymes, Immobilized', 'Humans', 'Mass Spectrometry'] | 9,187,379 | [['D01.132.250.075', 'D01.248.497.158.076', 'D02.203.130.075'], ['E05.196.181.349'], ['E05.196.181.400.300'], ['E05.196.181.400.383'], ['D09.254.229'], ['D08.811.180', 'D12.776.463.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.196.566']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Gastro-oesophageal candidiasis. | A prospective search for gastro-oesophageal candidiasis was made by histological examination of all the biopsies taken from 465 patients endoscoped consecutively during a 12 month period. The criterion for diagnosis was the demonstration of infiltration of tissue or ulcer slough by yeasts and hyphae. Nineteen cases of ... | ['Aged', 'Candidiasis', 'Esophageal Diseases', 'Female', 'Humans', 'Male', 'Middle Aged', 'Prospective Studies', 'Stomach Diseases'] | 7,068,036 | [['M01.060.116.100'], ['C01.150.703.160'], ['C06.405.117'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['C06.405.748']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
QTL mapping of the production of wine aroma compounds by yeast. | BACKGROUND: Wine aroma results from the combination of numerous volatile compounds, some produced by yeast and others produced in the grapes and further metabolized by yeast. However, little is known about the consequences of the genetic variation of yeast on the production of these volatile metabolites, or on the meta... | ['Acyclic Monoterpenes', 'Alleles', 'Chromosome Mapping', 'Fermentation', 'Gene Deletion', 'Genetic Variation', 'Metabolic Networks and Pathways', 'Monoterpenes', 'Odorants', 'Organic Chemicals', 'Quantitative Trait Loci', 'Saccharomyces cerevisiae', 'Sesquiterpenes', 'Vitis', 'Wine'] | 23,110,365 | [['D02.455.849.575.125'], ['G05.360.340.024.340.030'], ['E05.393.183'], ['G02.111.158.249', 'G03.191.249'], ['G05.365.590.762.320', 'G05.558.800.320'], ['G05.365'], ['G03.493'], ['D02.455.849.575'], ['G16.500.275.640', 'N06.230.480'], ['D02'], ['G05.360.340.024.380.937'], ['B01.300.107.795.785.800', 'B01.300.930.705.65... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Trace metals and radionuclides in macroalgae from Moroccan coastal waters. | Macroalgae species Codium sp, Bangia atropurpurea, Membranoptera alata, Plocamium cartilagineum, Dictyota dichotoma, Fucus spiralis and Stypocaulon scoparia were collected from seven stations along the north coast of Morocco. Samples were analysed to determine activities of naturally occurring radionuclides ((210)Pb, U... | ['Environmental Monitoring', 'Metals', 'Morocco', 'Radioisotopes', 'Seawater', 'Seaweed', 'Water Pollutants, Chemical', 'Water Pollution, Chemical'] | 21,298,402 | [['N06.850.460.350.080', 'N06.850.780.375'], ['D01.552'], ['Z01.058.266.629'], ['D01.496.749'], ['G16.500.275.725.500'], ['B05.080.750'], ['D27.888.284.903.655'], ['N06.850.460.790.410']] | ['Health Care [N]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Blood plasma binding of acebutolol and diacetolol in man. | 1 Acebutolol or diacetolol were added to fresh human plasma in varying concentrations and their extent of binding at 25 degrees C measureed by an equilibrium dialysis technique. 2 The extent of binding for both compounds was shown to be very low, being 11-19% for acebutolol and 6-9% for diacetolol. 3 Partition coeffici... | ['Acebutolol', 'Blood Proteins', 'Humans', 'In Vitro Techniques', 'Protein Binding', 'Solubility'] | 7,378,256 | [['D02.033.100.624.698.025', 'D02.033.755.624.698.025', 'D02.092.063.624.698.025'], ['D12.776.124'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.481'], ['G02.111.679', 'G03.808'], ['G02.805']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Lingual mandibular bone concavity. | The lingual mandibular bone concavity is not pathognomonic but is a radiographic bone entity. The origin of the entity and the histologic picture of the contents found within the concavity are probably related to the size and growth of the structures located in the submandibular space and the contiguous area. This acco... | ['Biopsy', 'Bone Cysts', 'Mandible', 'Mandibular Diseases', 'Radiography, Panoramic', 'Terminology as Topic'] | 1,054,053 | [['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['C04.182.089', 'C05.116.070'], ['A02.835.232.781.324.502.632', 'A14.521.632'], ['C05.500.607', 'C07.320.610'], ['E01.370.350.700.720.750', 'E06.342.764.750'], ['L01.559.598.40... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]', 'Information Science [L]'] | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. II. Purification and characterization. | This paper describes the purification and characterization of a sterol regulatory element binding protein (SREBP) that recognizes the SRE-1 sequence in the 5' flanking region of the gene for the low density lipoprotein (LDL) receptor. The protein was purified more than 38,000-fold from nuclear extracts of human HeLa ce... | ['Base Sequence', 'Binding Sites', 'CCAAT-Enhancer-Binding Proteins', 'Cell Nucleus', 'Chromatography, Affinity', 'Chromatography, Gel', 'Chromatography, Ion Exchange', 'DNA-Binding Proteins', 'Electrophoresis, Polyacrylamide Gel', 'HeLa Cells', 'Humans', 'Kinetics', 'Molecular Sequence Data', 'Molecular Weight', 'Nucl... | 8,314,806 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G02.111.570.120'], ['D12.776.260.108.124', 'D12.776.660.167', 'D12.776.930.127.124'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['E05.196.181.400.170'], ['E05.196.181.400.250'], ['E05.196.181.400.383'], ['D12.776.260'], ['E05.196.401.402', 'E05.301... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Innervation and neural regulation of the sex pheromone gland in female Heliothis moths. | Female Heliothis moths normally produce their species-specific male attractant (sex pheromone blend) during scotophase, and this production is stimulated by pheromone biosynthesis activating neuropeptide (PBAN), presumably carried in the hemolymph. Several lines of evidence indicate that the central nervous system play... | ['Animals', 'Electric Stimulation', 'Endocrine Glands', 'Female', 'In Vitro Techniques', 'Male', 'Moths', 'Nervous System', 'Nervous System Physiological Phenomena', 'Octopamine', 'Pheromones'] | 2,052,579 | [['B01.050'], ['E05.723.402'], ['A06.300'], ['E05.481'], ['B01.050.500.131.617.720.500.500.937.650'], ['A08'], ['G11.561'], ['D02.033.100.291.525', 'D02.092.063.291.525', 'D02.092.211.215.811.651', 'D02.092.471.683.725'], ['D23.641']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Dynamics of Purcell's three-link microswimmer with a passive elastic tail. | One of the few possible mechanisms for self-propulsion at low Reynolds number is undulations of a passive elastic tail, as proposed in the classical work of Purcell (1977). This effect is studied here by investigating a variant of Purcell's three-link swimmer model where the front joint angle is periodically actuated w... | ['Elasticity', 'Microbiology', 'Models, Biological', 'Movement'] | 22,907,616 | [['G01.374.590'], ['H01.158.273.540'], ['E05.599.395'], ['G07.568', 'G11.427.410']] | ['Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
[Effects of sodium hypochlorite on structure and function of pond microcosms]. | OBJECTIVE: To study the influence of sodium hypochlorite on destruction and restoration of simulated pond ecosystems.METHODS: Six pond microcosms were established to simulate aquatic ecosystems. 0, 1, 2.5, 5.0, 10.0 and 20.0 mg/L of sodium hypochlorite were put in these simulated pond microcosms every 24 h for 13 days ... | ['Bacteria', 'Chlorophyll', 'Chlorophyll A', 'Disinfectants', 'Dose-Response Relationship, Drug', 'Ecosystem', 'Fresh Water', 'Sodium Hypochlorite', 'Water Microbiology'] | 17,555,086 | [['B03'], ['D03.383.129.578.840.374', 'D03.633.400.909.374', 'D04.345.783.374'], ['D03.383.129.578.840.374.140', 'D03.633.400.909.374.140', 'D04.345.783.374.140'], ['D27.505.954.122.425', 'D27.720.274'], ['G07.690.773.875', 'G07.690.936.500'], ['G16.500.275.157', 'N06.230.124'], ['G16.500.275.280', 'N06.230.232'], ['D0... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Cross-modal plasticity among sensory networks in neuromyelitis optica spectrum disorders. | OBJECTIVE: To explore resting-state (RS) functional connectivity (FC) of the main sensory/motor networks of patients with neuromyelitis optica spectrum disorders (NMOSDs), clinically isolated optic neuritis (ON), and myelitis.METHODS: Clinical evaluation and RS fMRI were obtained from 28 NMOSD, 11 recurrent ON, and 12 ... | ['Adult', 'Connectome', 'Female', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Nerve Net', 'Neuromyelitis Optica', 'Neuronal Plasticity', 'Sensorimotor Cortex'] | 29,771,186 | [['M01.060.116'], ['E01.370.350.578.875.500.249', 'E01.370.376.537.625.500.249', 'E05.629.875.500.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['M01.060.116.630'], ['A08.511'], ['C10.114.375.600.500', 'C10.114.375.800', 'C10.292.700.550.500', 'C10.314.350.600.500', 'C10.314.350.800',... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Emergency medical information system for transferring patients to the medical institute by triage-result. | The Objective of this study was to triage the emergency patients in a pre-hospital stage and transfer them to the appropriate medical institute by the triaged result. For this, considering the pre-hospital emergence situation, we selected the Manchester system as the triage. So we analyzed the components of the ambulan... | ['Emergency Service, Hospital', 'Hospital Information Systems', 'Humans', 'Korea', 'Patient Transfer', 'Triage'] | 17,102,448 | [['N02.278.216.500.968.336', 'N02.421.297.195', 'N04.452.442.452.422.336'], ['N04.452.442.452.452', 'N04.452.515.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.474.557', 'Z01.586.407'], ['E02.760.169.624', 'E02.760.400.630', 'N02.421.585.169.624', 'N02.421.585.400.630', 'N04.590.233.727.210.624'], ['... | ['Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
[Anesthesia unrelated triggering of a fatal malignant hyperthermia crisis]. | For incidents of malignant hyperthermia (MH) outside the hospital, a high number of unrecorded cases must be reckoned with because of an insufficient knowledge of emergency services and poor identification and documentation that make it impossible to classify acute situations under the diagnosis of malignant hypertherm... | ['Adult', 'Alcohol Drinking', 'Anesthesia, General', 'Fatal Outcome', 'Heart Arrest', 'Humans', 'Male', 'Malignant Hyperthermia'] | 9,451,492 | [['M01.060.116'], ['F01.145.317.269'], ['E03.155.197'], ['E05.318.308.985.550.325', 'N01.224.935.698.201', 'N06.850.505.400.975.550.325', 'N06.850.520.308.985.550.325'], ['C14.280.383'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.505.700', 'C23.550.767.600']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Studies on the life history of Megaselia scalaris (Loew) in Thailand. | The morphological, life-cycle, and experimental studies of Megaselia scalaris were reported. This fly is commonly found both in urban and rural areas in Thailand. It is easily identified and the humped thorax was the most distinct characteristic of the adult. The egg to the adult stage and the life span required 15 to ... | ['Animals', 'Diptera', 'Female', 'Male', 'Myiasis', 'Rats', 'Thailand'] | 887,997 | [['B01.050'], ['B01.050.500.131.617.720.500.500.750'], ['C01.610.858.211.503'], ['B01.050.150.900.649.313.992.635.505.700'], ['Z01.252.145.841']] | ['Organisms [B]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Tolerance induction by a poorly arthritogenic collagen II can prevent collagen-induced arthritis. | Collagen type II (CII)-induced arthritis (CIA) can be induced in 78% of B10.RIII mice (H2r) by intradermal (id) immunization with CII of bovine origin in complete Freund's adjuvant (CFA), whereas immunization with CII of chick origin induces arthritis in less than 5% of these mice. Nevertheless, tolerization of B10.RII... | ['Animals', 'Arthritis', 'Arthritis, Experimental', 'Cattle', 'Chickens', 'Collagen', 'Immune Tolerance', 'Injections, Intradermal', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Mice, Inbred DBA', 'Species Specificity', 'Time Factors'] | 3,401,929 | [['B01.050'], ['C05.550.114'], ['C05.550.114.015', 'E05.598.500.249'], ['B01.050.150.900.649.313.500.380.271'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['D05.750.078.280', 'D12.776.860.300.250'], ['G12.535.425'], ['E02.319.267.530.620.410'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Determination of methylxanthines in urine by liquid chromatography with diode array UV detection. | A liquid chromatography-diode array UV detection (LC-UVDAD) method for the simultaneous determination of four methylxanthines (caffeine, theobromine, paraxanthine and theophylline) is described. The chromatographic separation was achieved on a LC-18-DB column using 20:80 methanol:buffer (5mM citric acid adjusted to pH ... | ['Chromatography, Liquid', 'Humans', 'Spectrophotometry, Ultraviolet', 'Xanthines'] | 15,522,539 | [['E05.196.181.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.196.712.726.802', 'E05.196.867.826.802'], ['D03.132.960', 'D03.633.100.759.758.824']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Diagnosis of renal metanephric adenoma: relevance of immunohistochemistry and biopsy]. | Most renal tumors of the adult are carcinomas. Their treatment is surgical, consisting of limited excision or nephrectomy. In some instances, biopsy of the tumor can be performed in order to adapt treatment. We report the case of a 45 year-old woman presenting with renal tumor. A biopsy of the mass showed a metanephric... | ['Adenoma', 'Adult', 'Biopsy', 'Humans', 'Immunohistochemistry', 'Kidney Neoplasms'] | 18,185,471 | [['C04.557.470.035'], ['M01.060.116'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.75... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Awareness of general practitioners towards treatment of laryngopharyngeal reflux: a British survey. | OBJECTIVE: Patients with acid reflux can occasionally present with atypical symptoms such as globus pharyngeus, constant throat clearing, chronic cough, hoarseness, catarrh, choking episodes or asthma-like symptoms. The aim of this survey was to determine whether general practitioners are aware of the atypical manifest... | ['Anti-Ulcer Agents', 'Clinical Competence', 'Gastroesophageal Reflux', 'Health Care Surveys', 'Humans', 'Hypopharynx', 'Life Style', 'Physicians, Family', 'Proton Pump Inhibitors', 'United Kingdom'] | 16,213,919 | [['D27.505.954.483.203'], ['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['C06.405.117.119.500.484'], ['E05.318.308.980.344', 'N03.349.380.210', 'N05.425.210', 'N05.715.360.300.800.344', 'N06.850.520.308.980.344'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A04.623.490', 'A14.724.490'], ['F01.829.458'], ['M... | ['Chemicals and Drugs [D]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Named Groups [M]', 'Geographicals [Z]'] | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Genetic Alterations and Their Clinical Implications in High-Recurrence Risk Papillary Thyroid Cancer. | PURPOSE: Papillary thyroid carcinomas (PTCs) frequently involve genetic alterations. The objective of this study was to investigate genetic alterations and further explore the relationships between these genetic alterations and clinicopathological characteristics in a high-recurrence risk (node positive, N1) PTC group.... | ['Adult', 'Aged', 'Biomarkers, Tumor', 'Carcinoma, Papillary', 'Class I Phosphatidylinositol 3-Kinases', 'DNA Mutational Analysis', 'Female', 'Gene Expression', 'Genes, ras', 'Genetic Association Studies', 'Genetic Variation', 'Humans', 'Kaplan-Meier Estimate', 'Male', 'Middle Aged', 'Mutation', 'Neoplasm Metastasis', ... | 28,052,655 | [['M01.060.116'], ['M01.060.116.100'], ['D23.101.140'], ['C04.557.470.200.360', 'C04.557.470.700.360'], ['D08.811.913.696.620.500.100.100', 'D08.811.913.696.620.500.200.100', 'D12.776.476.162'], ['E05.393.760.700.300'], ['G05.297'], ['G05.360.340.024.340.375.500.791.550'], ['E05.393.385'], ['G05.365'], ['B01.050.150.90... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
TGF-â1 levels and intraocular tissue alterations in mice infected with a virulent type I RH Toxoplasma gondii strain. | Toxoplasmosis is generally self-limiting in healthy adults but it may cause toxoplasmic retinochoroiditis in cases of congenital infection leading to blindness. The importance of host genetics in determining disease severity in ocular toxoplasmosis has been shown in different inbred mouse strains using low-virulence to... | ['Animals', 'Aqueous Humor', 'Cytokines', 'Down-Regulation', 'Eye', 'Female', 'Immunity, Cellular', 'Inflammation', 'Mice', 'Mice, Inbred BALB C', 'Toxoplasma', 'Toxoplasmosis, Animal', 'Toxoplasmosis, Ocular', 'Transforming Growth Factor beta1', 'Virulence'] | 26,773,166 | [['B01.050'], ['A09.371.060.067.070', 'A12.207.270.040'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['A01.456.505.420', 'A09.371'], ['G12.450.050.400'], ['C23.550.470'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.338', 'B01.050.... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mapping of eight testis-specific genes to mouse chromosomes. | We previously identified eight testis-specific genes using antibodies raised against testicular germ cells. They are expressed during spermatogenesis and are presumed to be involved in testicular germ cell differentiation and sperm formation. We have mapped the genomic loci for these testis-specific genes using restric... | ['Animals', 'Calcium-Binding Proteins', 'Calnexin', 'Chromosome Mapping', 'Crosses, Genetic', 'DNA-Binding Proteins', 'Genes', 'Insulin', 'Male', 'Mice', 'Mice, Inbred C3H', 'Molecular Chaperones', 'Molecular Sequence Data', 'Muridae', 'Nerve Tissue Proteins', 'Nuclear Proteins', 'Phosphoproteins', 'Polymorphism, Restr... | 9,403,069 | [['B01.050'], ['D12.776.157.125'], ['D12.644.360.372.311', 'D12.776.157.125.412.311', 'D12.776.476.387.311', 'D12.776.503.295', 'D12.776.543.162'], ['E05.393.183'], ['E05.393.281'], ['D12.776.260'], ['G05.360.340.024.340'], ['D06.472.699.587.200.500.625', 'D12.644.548.586.200.500.625'], ['B01.050.150.900.649.313.992.63... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
The Provision of Health Care by Family Physicians in Taiwan as Illustrated With Population Pyramids. | Family physicians serve as personal doctors for individuals and their families and also act as gatekeepers of the health care system. If no special status is accorded to family physicians, however, then the rates at which health care recipients utilize their service might be affected. In the present cross-sectional stu... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Ambulatory Care', 'Child', 'Child, Preschool', 'Chronic Disease', 'Cross-Sectional Studies', 'Female', 'Humans', 'Infant', 'Infant, Newborn', 'Male', 'Medicine', 'Middle Aged', 'National Health Programs', 'Physicians, Family', 'Taiwan', 'Young Adult'] | 30,947,595 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E02.760.106', 'N02.421.585.106'], ['M01.060.406'], ['M01.060.406.448'], ['C23.550.291.500'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'],... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
The value of post-mortem CT in neonaticide in case of severe decomposition: description of 12 cases. | INTRODUCTION: In cases of neonaticide with delayed finding of the body, interpretation of autopsy results can be difficult because of decomposition. Postmortem computed tomography (PMCT) has become an increasingly popular tool in the (pediatric) forensic field. We performed a retrospective study to compare the outcome ... | ['Age Determination by Skeleton', 'Female', 'Femur', 'Foot', 'Forensic Pathology', 'Gestational Age', 'Humans', 'Imaging, Three-Dimensional', 'Infant, Newborn', 'Infanticide', 'Live Birth', 'Male', 'Multidetector Computed Tomography', 'Postmortem Changes', 'Retrospective Studies', 'Stillbirth'] | 24,314,533 | [['E01.370.049', 'E01.370.350.700.050'], ['A02.835.232.043.150'], ['A01.378.610.250'], ['H02.403.330.300', 'H02.403.650.249', 'I01.198.780.937.460'], ['G07.345.500.325.235.968', 'G08.686.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.400', 'L01.224.308.410'], ['M01.060.703.520'], ['I01.198.240.47... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Information Science [L]', 'Named Groups [M]', 'Diseases [C]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 |
Induction of CD8+ regulatory T cells protects macaques against SIV challenge. | Efforts to develop a vaccine against HIV have so far met with limited success. Given that CD4(+) T cell activation drives the initial burst of viral replication, we explored in macaques whether an oral vaccine comprised of Lactobacillus plantarum, a commensal bacterium that favors immune tolerance, and inactivated simi... | ['Animals', 'CD4-Positive T-Lymphocytes', 'CD8-Positive T-Lymphocytes', 'Female', 'Lactobacillus plantarum', 'Lymphocyte Activation', 'Macaca mulatta', 'Male', 'SAIDS Vaccines', 'Simian Acquired Immunodeficiency Syndrome', 'Simian Immunodeficiency Virus'] | 23,260,669 | [['B01.050'], ['A11.118.637.555.567.569.200', 'A15.145.229.637.555.567.569.200', 'A15.382.490.555.567.569.200'], ['A11.118.637.555.567.569.220', 'A15.145.229.637.555.567.569.220', 'A15.382.490.555.567.569.220'], ['B03.353.750.450.475.612', 'B03.510.460.400.410.475.475.612', 'B03.510.550.450.475.612'], ['E01.370.225.812... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Brunner's gland adenomas: clinical presentation and surgical management. | Tumors of the Brunner's glands are rare, and the etiology remains obscure. Bleeding is the most common presenting symptom and may be occult or exsanguinating. Gastric outlet or duodenal obstruction may also occur. Often there is a history of preexisting nonspecific upper gastrointestinal symptoms, or the adenoma may be... | ['Adenoma', 'Aged', 'Brunner Glands', 'Duodenal Neoplasms', 'Duodenal Obstruction', 'Duodenum', 'Female', 'Gastrointestinal Hemorrhage', 'Humans', 'Male', 'Middle Aged'] | 316,193 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Comparison of mother, father, and teacher reports of ADHD core symptoms in a sample of child psychiatric outpatients. | OBJECTIVE: To explore the significance of adding father ratings to mother and teacher ratings in the assessment of ADHD symptoms in children.METHOD: The ADHD Rating Scale-IV, the Child Behavior Checklist, and the Teacher Report Form were filled out by all three informants for a sample of 48 clinically referred children... | ['Adolescent', 'Attention Deficit Disorder with Hyperactivity', 'Child', 'Faculty', 'Fathers', 'Female', 'Humans', 'Male', 'Mothers', 'Outpatients', 'Symptom Assessment'] | 22,441,890 | [['M01.060.057'], ['F03.625.094.150'], ['M01.060.406'], ['M01.526.702.250'], ['F01.829.263.500.320.100', 'I01.880.853.150.500.340.210', 'M01.620.390'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.263.500.320.200', 'I01.880.853.150.500.340.270', 'M01.620.630'], ['M01.643.630'], ['E01.370.872']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Craniometaphyseal dysplasia. Report of a case. | Craniometaphyseal dysplasia, often referred to as Pyle's disease, is a hereditary disease involving the expansion of the metaphyses of the long bones, giving the appearance of an Erlenmeyer flask. There is diffuse hyperostosis of the entire cranial vault, along with absence or decreased development of the paranasal sin... | ['Bone Diseases, Developmental', 'Child', 'Dentition', 'Female', 'Follow-Up Studies', 'Humans', 'Malocclusion', 'Maxilla', 'Skull'] | 1,058,438 | [['C05.116.099'], ['M01.060.406'], ['A03.556.500.379', 'A14.549.167'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C07.793.494'], ['A02.835.232.781.324.502.645', 'A14.521.645'], ['A02.835.232.781']] | ['Diseases [C]', 'Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Osteoarthritis antirheumatic drug trials. II. Tables for calculating sample size for clinical trials. | The calculation of sample size for clinical trials requires knowledge of the standard deviation (SD) of index variables. There are no published lists of SD and it is difficult to locate variance estimates based on relevant populations. In this study we used standardized procedures to determine in 60 patients with osteo... | ['Clinical Trials as Topic', 'Humans', 'Osteoarthritis', 'Research Design'] | 1,578,461 | [['E05.318.372.250.250', 'N05.715.360.330.250.250', 'N06.850.520.450.250.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C05.550.114.606', 'C05.799.613'], ['E05.581.500', 'H01.770.644.728']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Vulnerability and fragility risk indices for non-renewable resources. | Protected areas are tasked with mitigating impacts to a wide range of invaluable resources. These resources are often subject to a variety of potential natural and anthropogenic impacts that require monitoring efforts and management actions to minimize the degradation of these resources. However, due to insufficient fu... | ['Caves', 'Conservation of Natural Resources', 'Environmental Monitoring', 'Humans', 'Parks, Recreational', 'Risk', 'Risk Assessment'] | 29,860,559 | [['G01.311.169', 'G16.500.275.067', 'N06.230.066'], ['J01.256', 'N06.230.080'], ['N06.850.460.350.080', 'N06.850.780.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['J03.925.680'], ['E05.318.740.600.800', 'G17.680.750', 'N05.715.360.750.625.700', 'N06.850.520.830.600.800'], ['E05.318.740.600.800.715', 'N04.452... | ['Phenomena and Processes [G]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
[Premorbid personality as a risk factor in the appearance of psychological and behavioural symptoms of dementia: Systematic review]. | The aetiology of behavioural and psychological symptoms of dementia (BPSD) is defined by a diversity of factors, and recent studies suggest that premorbid personality could be a risk factor for BPSD. This study aimed to review studies on the relationship between premorbid personality and BPSD. Studies were identified u... | ['Aged', 'Dementia', 'Humans', 'Mental Disorders', 'Personality', 'Risk Factors'] | 30,482,462 | [['M01.060.116.100'], ['C10.228.140.380', 'F03.615.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F03'], ['F01.752'], ['E05.318.740.600.800.725', 'N05.715.350.200.700', 'N05.715.360.750.625.700.700', 'N06.850.490.625.750', 'N06.850.520.830.600.800.725']] | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The role of National Institutes of Health category IV prostatitis in accurately staging the newly diagnosed prostate cancer. | BACKGROUND: It has been known that the National Institutes of Health category IV (NIH-IV) prostatitis increases the serum total prostate-specific antigen (tPSA) in patients with benign prostatic hyperplasia. However, the effect of NIH-IV prostatitis on tPSA levels, which are used for staging prostate cancer (PCa) in pa... | ['Aged', 'Humans', 'Male', 'Middle Aged', 'Neoplasm Staging', 'Prostate-Specific Antigen', 'Prostatic Neoplasms', 'Prostatitis', 'Statistics, Nonparametric', 'United States'] | 23,370,973 | [['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.789.625'], ['D08.811.277.656.300.760.442.750', 'D08.811.277.656.959.350.442.750', 'D12.776.866.249.500', 'D23.050.285.625', 'D23.101.140.625'], ['C04.588.945.440.770', 'C12.294.260.750', 'C12.294.565.625', 'C12.758.409.750... | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Central pontine myelinolysis after living donor liver transplantation. | There are few reports of central pontine myelinolysis after living donor liver transplantation. A 59-year-old male received a right liver graft from his daughter for hepatitis B-related liver cirrhosis. Methylprednisolone and tracrolimus were used for immunosuppression. Dysarthria and dysphasia were noted on the second... | ['Humans', 'Liver Transplantation', 'Living Donors', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Myelinolysis, Central Pontine'] | 15,011,876 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.095.147.725.490', 'E04.210.650', 'E04.936.450.490', 'E04.936.580.490'], ['M01.898.656'], ['E01.370.350.825.500'], ['M01.060.116.630'], ['C10.228.140.163.560', 'C10.314.500', 'C18.452.132.560']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Chronic hepatitis C infection and liver disease in HIV-coinfected patients in Asia. | Data on markers of hepatitis C virus (HCV) disease in HIV-HCV-coinfected patients in resource-limited settings are scarce. We assessed HCV RNA, HCV genotype (GT), IL28B GT and liver fibrosis (FibroScan® ) in 480 HIV-infected patients with positive HCV antibody in four HIV treatment centres in South-East Asia. We enroll... | ['Adult', 'Alleles', 'Asia, Southeastern', 'CD4 Lymphocyte Count', 'Coinfection', 'Female', 'Genotype', 'HIV Infections', 'Hepacivirus', 'Hepatitis C Antibodies', 'Hepatitis C, Chronic', 'Humans', 'Interferons', 'Interleukins', 'Liver Cirrhosis', 'Male', 'Middle Aged', 'RNA, Viral', 'Viral Load'] | 27,917,597 | [['M01.060.116'], ['G05.360.340.024.340.030'], ['Z01.252.145'], ['E01.370.225.500.195.107.595.500.150', 'E01.370.225.625.107.595.500.150', 'E05.200.500.195.107.595.500.150', 'E05.200.625.107.595.500.150', 'E05.242.195.107.595.500.150', 'G04.140.107.595.500.150', 'G09.188.105.595.500.150'], ['C01.218'], ['G05.380'], ['C... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
Molecular events associated with dysplastic morphologic transformation and initiation of ovarian tumorigenicity. | BACKGROUND: Disabled-2 (Dab2), a candidate tumor suppressor of ovarian carcinoma, frequently (around 80%) loses its expression in ovarian tumors. Expression of exogenous Dab2 in tumor cell lines negatively regulates growth and suppresses the downstream signal of the Ras/mitogen activated protein kinase mitogenic pathwa... | ['Adaptor Proteins, Signal Transducing', 'Adaptor Proteins, Vesicular Transport', 'Adult', 'Aged', 'Antigens, Nuclear', 'Apoptosis Regulatory Proteins', 'Basement Membrane', 'Cell Transformation, Neoplastic', 'Collagen', 'Epithelial Cells', 'Female', 'Genes, Tumor Suppressor', 'Humans', 'Immunohistochemistry', 'Ki-67 A... | 12,015,763 | [['D12.644.360.024', 'D12.776.157.057', 'D12.776.476.024'], ['D12.776.543.990.150'], ['M01.060.116'], ['M01.060.116.100'], ['D12.776.660.625', 'D23.050.290'], ['D12.644.360.075', 'D12.776.476.075'], ['A10.272.220', 'A10.615.179'], ['C04.697.098.500', 'C23.550.727.098.500'], ['D05.750.078.280', 'D12.776.860.300.250'], [... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Partial nephrectomy in the treatment of renal adenocarcinoma. | During a 20-year period 17 patients underwent partial nephrectomy as primary curative therapy for renal adenocarcinoma. In 15 patients (88 per cent) partial nephrectomy was performed satisfactorily in situ with free margins of resection. Eleven patients are alive (65 per cent) and only 3 (17 per cent) died of recurrent... | ['Adenocarcinoma', 'Adult', 'Aged', 'Female', 'Humans', 'Kidney Neoplasms', 'Male', 'Middle Aged', 'Nephrectomy', 'Ohio', 'Recurrence'] | 926,268 | [['C04.557.470.200.025'], ['M01.060.116'], ['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.945.947.535', 'C12.758.820.750', 'C12.777.419.473', 'C13.351.937.820.535', 'C13.351.968.419.473'], ['M01.060.116.630'], ['E04.950.774.435'], ['Z01.107.567.875.075.512', 'Z01.107.567.875.350.540', '... | ['Diseases [C]', 'Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
Deciphering the 8q24.21 association for glioma. | We have previously identified tagSNPs at 8q24.21 influencing glioma risk. We have sought to fine-map the location of the functional basis of this association using data from four genome-wide association studies, comprising a total of 4147 glioma cases and 7435 controls. To improve marker density across the 700 kb regio... | ['Alleles', 'Case-Control Studies', 'Chromosome Mapping', 'Chromosomes, Human, Pair 8', 'European Continental Ancestry Group', 'Genetic Association Studies', 'Genotype', 'Glioma', 'Humans', 'Neoplasm Grading', 'Odds Ratio', 'Polymorphism, Single Nucleotide'] | 23,399,484 | [['G05.360.340.024.340.030'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['E05.393.183'], ['A11.284.187.520.300.325.340', 'G05.360.162.520.300.325.340'], ['M01.686.508.400'], ['E05.393.385'], ['G05.380'], ['C04.557.465.625.600.380', 'C04.557.470.670.380', 'C04.557.580.625.600.380'], ... | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Named Groups [M]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Variations of patient doses in interventional examinations at different angiographic units. | PURPOSE: We analyzed doses for various angiographic procedures using different X-ray systems in order to assess dose variations.METHODS: Dose-area product (DAP), skin doses from thermoluminescent dosimeters and air kerma measurements of 308 patients (239 diagnostic and 69 interventional) were assessed for five differen... | ['Angiography', 'Fluoroscopy', 'Humans', 'Radiation Dosage', 'Radiography, Interventional', 'Thermoluminescent Dosimetry'] | 16,718,424 | [['E01.370.350.700.060', 'E01.370.370.050'], ['E01.370.350.700.225'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.799.513', 'G01.750.740', 'N06.850.810.250'], ['E01.370.350.700.725', 'E04.502.780'], ['E05.799.638.785', 'N06.850.810.370.420']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Using codon optimization, chaperone co-expression, and rational mutagenesis for production and NMR assignments of human eIF2 alpha. | Producing a well behaved sample at high concentration is one of the main hurdles when starting a new project on an interesting protein. Especially when one attempts to overexpress a eukaryotic protein in bacteria, some difficulties are encountered, such as low expression level, low solubility, or even lack of folded st... | ['Amino Acid Sequence', 'Codon', 'Escherichia coli', 'Eukaryotic Initiation Factor-2', 'Gene Expression Regulation, Bacterial', 'Humans', 'Magnetic Resonance Imaging', 'Molecular Chaperones', 'Molecular Sequence Data', 'Mutagenesis', 'Mutation', 'Protein Structure, Secondary', 'Sequence Alignment', 'Solubility'] | 14,872,127 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D13.444.735.544.355', 'G05.360.335.355', 'G05.360.340.024.340.137.190'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D12.776.835.725.868.249'], ['G05.308.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['D12.776.580'], ['L01.4... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Trans-Tenon's retrobulbar triamcinolone infusion for myopic choroidal neovascularization. | PURPOSE: To report the effects of trans-Tenon's retrobulbar injection of triamcinolone acetonide for subfoveal and juxtafoveal choroidal neovascularization (CNV) caused by pathological myopia.METHODS: Eleven consecutive patients (11 eyes) with myopic CNV were treated with trans-Tenon's retrobulbar injection of triamcin... | ['Adult', 'Aged', 'Choroidal Neovascularization', 'Fascia', 'Female', 'Fluorescein Angiography', 'Glucocorticoids', 'Humans', 'Infusions, Parenteral', 'Male', 'Middle Aged', 'Myopia, Degenerative', 'Orbit', 'Tomography, Optical Coherence', 'Triamcinolone Acetonide', 'Visual Acuity'] | 17,083,532 | [['M01.060.116'], ['M01.060.116.100'], ['C11.941.160.244', 'C23.550.589.500.145'], ['A02.340', 'A10.165.425'], ['E01.370.370.050.350', 'E01.370.380.250'], ['D06.472.040.543', 'D27.505.696.399.472.488'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.267.510'], ['M01.060.116.630'], ['C11.744.636.500'], ['A02... | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Understanding and using organizational politics, Part Two. | Politics is a fact of life in industry, academia, the military, religion, and even health care. Remember these five major ideas: 1. Politics exists in organizations. 2. Politics can be understood. 3. Politics can be managed. 4. Denial won't make politics go away. 5. You can become a better and more ethical organization... | ['Leadership', 'Organizational Innovation', 'Organizational Objectives', 'Organizational Policy', 'United States'] | 15,222,156 | [['F01.752.609'], ['N04.452.610'], ['N04.452.615'], ['I01.655.500.550', 'I01.880.604.825.550', 'N03.623.500.550'], ['Z01.107.567.875']] | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Air in the aorta: treatment by reversed perfusion. | A ventricular septal defect was repaired in a 3 1/2-year-old child on cardiopulmonary bypass. Because of excessive pulmonary venous return, a period of circulatory arrest under deep hypothermia was used. A large volume of air was found in the arterial line and the ascending aorta before perfusion was reinstituted. The ... | ['Aortic Diseases', 'Cardiopulmonary Bypass', 'Child, Preschool', 'Embolism, Air', 'Female', 'Humans', 'Perfusion'] | 3,954,509 | [['C14.907.109'], ['E04.292.413'], ['M01.060.406.448'], ['C14.907.355.350.254'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.680']] | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Menstrual cycle modulation of the relationship between cortisol and long-term memory. | Numerous cognitive effects of fluctuations in ovarian hormones across the menstrual cycle have been previously identified. However, the influence of ovarian hormones on learning under stressful conditions is not well understood. In this experiment, the relationship between salivary cortisol and recall performance was a... | ['Adolescent', 'Adult', 'Female', 'Gonadal Steroid Hormones', 'Humans', 'Hydrocortisone', 'Memory', 'Menstrual Cycle', 'Mental Recall', 'Saliva', 'Stress, Psychological', 'Time Factors'] | 18,468,808 | [['M01.060.057'], ['M01.060.116'], ['D06.472.334.851'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D04.210.500.745.745.654.600', 'D06.472.040.585.353.476', 'D06.472.040.585.478.392'], ['F02.463.425.540'], ['G08.686.605'], ['F02.463.425.540.641'], ['A12.200.666'], ['F01.145.126.990', 'F02.830.900'], ['G01.910.85... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Silicone-fat differentiation in the breast: exploiting the bright-fat phenomenon in fast spin-echo MR imaging. | Selective suppression of silicone or fat with chemical shift-selective (CHESS) pulses is difficult because of the small chemical shift difference between the primary lipid signal and the primary silicone signal at 1.5 T. Differentiation of these chemically distinct species is, however, an important clinical task in ass... | ['Adipose Tissue', 'Breast', 'Breast Implants', 'Corn Oil', 'Equipment Failure', 'Female', 'Humans', 'Image Enhancement', 'Magnetic Resonance Imaging', 'Models, Structural', 'Signal Processing, Computer-Assisted', 'Silicones', 'Water'] | 7,865,948 | [['A10.165.114'], ['A01.236'], ['E07.695.140'], ['D10.212.302.380.370', 'D10.212.507.340', 'D10.627.700.240', 'D20.215.784.750.240', 'G07.203.300.375.400.250', 'J02.500.375.400.250'], ['E05.325'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.600.350', 'L01.224.308.380'], ['E01.370.350.825.500'], ['J01... | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Information Science [L]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Cluster organization and pore structure of ion channels formed by beticolin 3, a nonpeptidic fungal toxin. | Beticolin 3 (B3) belongs to a family of nonpeptidic phytotoxins produced by the fungus Cercospora beticola, which present a broad spectrum of cytotoxic effects. We report here that, at cytotoxic concentration (10 microM), B3 formed voltage-independent, weakly selective ion channels with multiple conductance levels in p... | ['Biophysical Phenomena', 'Biophysics', 'Electric Conductivity', 'Heterocyclic Compounds, 4 or More Rings', 'In Vitro Techniques', 'Ion Channels', 'Lipid Bilayers', 'Membrane Potentials', 'Models, Molecular', 'Molecular Conformation', 'Mycotoxins'] | 10,585,927 | [['G01.154'], ['H01.158.344', 'H01.671.100'], ['G01.358.500.249.277'], ['D03.633.400'], ['E05.481'], ['D12.776.157.530.400', 'D12.776.543.550.450', 'D12.776.543.585.400'], ['D10.570.510', 'J01.637.087.500.510'], ['G01.154.535', 'G04.580', 'G07.265.675', 'G11.561.570'], ['E05.599.595'], ['G02.111.570.820'], ['D23.946.58... | ['Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Antiobesity effects of etiocholanolones in diabetes (db), viable yellow (Avy), and normal mice. | Two metabolites of the adrenal steroid dehydroepiandrosterone (DHEA), 3 alpha-hydroxyetiocholanolone and 3 beta-hydroxyetiocholanolone, were found to have antiobesity properties with respect to both prevention of the development of obesity as well as weight reduction after obesity was established. All of the obesity ty... | ['Animals', 'Blood Glucose', 'Body Weight', 'Dehydroepiandrosterone', 'Diabetes Mellitus', 'Diabetes Mellitus, Experimental', 'Diet', 'Energy Intake', 'Etiocholanolone', 'Female', 'Insulin', 'Male', 'Mice', 'Mice, Inbred C3H', 'Mice, Inbred C57BL', 'Obesity'] | 2,933,245 | [['B01.050'], ['D09.947.875.359.448.500'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['D04.210.500.054.079.429.625', 'D04.210.500.578.502.400', 'D06.472.040.502.400', 'D06.472.334.851.968.952'], ['C18.452.394.750', 'C19.246'], ['C18.452.394.750.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Emergence of inflammatory alveolar macrophages during rejection or infection after lung transplantation. | Local activation of macrophages may play an important role in immune complications following lung transplantation. To document such a phenomenon, we have investigated the possible changes of alveolar macrophage surface antigen expression after lung transplantation. Using immunocytofluorometry, we have analyzed the phen... | ['Adolescent', 'Adult', 'Antigens, CD', 'Antigens, Differentiation, Myelomonocytic', 'Bronchoalveolar Lavage Fluid', 'Female', 'Graft Rejection', 'HLA-DR Antigens', 'Humans', 'Infections', 'Lipopolysaccharide Receptors', 'Lung Transplantation', 'Macrophages, Alveolar', 'Male', 'Middle Aged', 'Phenotype'] | 7,516,588 | [['M01.060.057'], ['M01.060.116'], ['D23.050.301.264.035', 'D23.101.100.110'], ['D23.050.301.264.900', 'D23.101.100.900'], ['E05.927.100.500'], ['G12.875.545.328'], ['D12.776.395.550.509.400.440', 'D12.776.543.550.440.400.440', 'D23.050.301.500.400.400.440', 'D23.050.301.500.450.400.440', 'D23.050.705.552.410.400.440',... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A method for preparing biologically active aqueous cyclosporin A solutions avoiding the use of detergents or organic solvents. | The immunosuppressive agent cyclosporin A (CsA) is highly hydrophobic and is, therefore, being taken for in vitro use directly from ethanolic stock solutions. In the present study it is demonstrated that ethanol itself affects several immunological activities in vitro, thus interfering with the immunosuppressive effect... | ["2',5'-Oligoadenylate Synthetase", 'Cell Line', 'Cyclosporins', 'Detergents', 'Enzyme Induction', 'Ethanol', 'Genes, myc', 'Humans', 'Interferon-gamma', 'Leukocytes, Mononuclear', 'Lymphocyte Activation', 'Lymphokines', 'Povidone', 'RNA, Messenger', 'Solubility', 'Solvents', 'Tumor Cells, Cultured'] | 2,125,618 | [['D08.811.913.696.445.625'], ['A11.251.210'], ['D04.345.566.235', 'D12.644.641.235'], ['D27.720.877.265', 'J01.516.381'], ['G05.308.320.200'], ['D02.033.375'], ['G05.360.340.024.340.375.500.791.420'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.440.893', 'D12.644.276.374.480.615.350', 'D12.776.4... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Microwave drying of selected greens and their sensory characteristics. | Green leafy vegetables which supply minerals and vitamins to the diet, are highly perishable. Therefore, post harvest losses are extremely high. Limited studies are available in the literature with regard to preservation of greens. The effect of microwave drying and storage on physical and sensory properties of selecte... | ['Amaranthus', 'Color', 'Coriandrum', 'Desiccation', 'Food Preservation', 'Mentha', 'Microwaves', 'Odorants', 'Sensation', 'Taste', 'Trigonella', 'Vegetables'] | 11,678,436 | [['B01.650.940.800.575.912.250.198.500.100.130'], ['G01.590.540.199'], ['B01.650.940.800.575.912.250.075.211'], ['E05.196.335', 'G02.176'], ['J01.576.423.850.700'], ['B01.650.940.800.575.912.250.583.520.483'], ['G01.358.500.505.810.500', 'G01.750.250.810.500', 'G01.750.770.721.500'], ['G16.500.275.640', 'N06.230.480'],... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Influence of SLCO1B1 and CYP2C8 gene polymorphisms on rosiglitazone pharmacokinetics in healthy volunteers. | Polymorphisms in drug transporter genes and/or drug-metabolising enzyme genes may contribute to inter-individual variability in rosiglitazone pharmacokinetics in humans. We sought to determine the joint effects of polymorphisms in the SLCO1B1 drug transporter gene and the cytochrome P450 ( CYP ) 2C8-metabolising enzyme... | ['Adolescent', 'Adult', 'Area Under Curve', 'Aryl Hydrocarbon Hydroxylases', 'Cytochrome P-450 CYP2C8', 'Female', 'Genotype', 'Health', 'Humans', 'Liver-Specific Organic Anion Transporter 1', 'Male', 'Middle Aged', 'Organic Anion Transporters', 'Polymorphism, Genetic', 'Rosiglitazone', 'Thiazolidinediones', 'Time Facto... | 19,129,086 | [['M01.060.057'], ['M01.060.116'], ['E05.318.740.200', 'G03.787.101', 'G07.690.725.064', 'N06.850.520.830.200'], ['D08.244.453.005', 'D08.811.682.690.708.170.010', 'D12.776.422.220.453.010'], ['D08.244.453.005.590', 'D08.244.453.491.368', 'D08.811.682.690.708.170.010.590', 'D08.811.682.690.708.170.450.360', 'D12.776.42... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Active growth factor delivery from poly(D,L-lactide-co-glycolide) foams prepared in supercritical CO(2). | A method for the production of microporous poly(D, L-lactide-co-glycolide) foams containing encapsulated proteins using supercritical carbon dioxide is described. Foams generated as aqueous protein emulsions in a polymer-solvent solution were saturated with carbon dioxide at supercritical conditions, and then suddenly ... | ['Animals', 'Biocompatible Materials', 'Carbon Dioxide', 'Cattle', 'Cold Temperature', 'Drug Carriers', 'Drug Delivery Systems', 'Fibroblast Growth Factor 2', 'Growth Substances', 'Lactic Acid', 'Methylene Chloride', 'Microscopy, Electron, Scanning', 'Polyglycolic Acid', 'Polylactic Acid-Polyglycolic Acid Copolymer', '... | 10,742,578 | [['B01.050'], ['D25.130', 'D27.720.102.130', 'J01.637.051.130'], ['D01.200.200', 'D01.362.150', 'D01.650.550.200'], ['B01.050.150.900.649.313.500.380.271'], ['G01.906.595.272', 'G16.500.275.063.725.710.300', 'G16.500.750.775.710.300', 'N06.230.300.100.725.154', 'N06.230.300.100.725.710.300'], ['D26.255.260', 'E02.319.3... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Five donors-one recipient: modeling a mosaic of granulocytes, natural killer and T cells from cord-blood and third-party donors. | BACKGROUND: A 21-year-old man was admitted to hospital because of leukocytosis, thrombocytopenia and anemia. The patient had been in good health until a few days earlier, when he developed fever and night sweats and his performance status dramatically declined.INVESTIGATIONS: Laboratory tests, immunophenotyping, cytoge... | ['Adult', 'Cell Transplantation', 'Cord Blood Stem Cell Transplantation', 'Granulocytes', 'Humans', 'Killer Cells, Natural', 'Male', 'Mosaicism', 'Precursor Cell Lymphoblastic Leukemia-Lymphoma', 'T-Lymphocytes'] | 18,364,724 | [['M01.060.116'], ['E02.095.147.500', 'E04.936.225'], ['E02.095.147.500.500.312', 'E04.936.225.687.312'], ['A11.118.637.415', 'A11.148.350', 'A11.627.340', 'A15.145.229.637.415', 'A15.378.316.340', 'A15.382.490.315'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.118.637.555.567.537', 'A15.145.229.637.555.567.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The role of eicosanoids in cyclosporine nephrotoxicity in the rat. | Nephrotoxicity is the most troublesome complication of cyclosporine (CSA) therapy. The present study was designed to investigate the effects of chronic treatment with CSA on the 24-hr urinary excretion of prostanoids (PGs) and thromboxane (Tx) and on the renal function in the absence or presence of indomethacin. CSA ad... | ['Animals', 'Cyclosporins', 'In Vitro Techniques', 'Kidney', 'Kidney Cortex', 'Kidney Medulla', 'Male', 'Prostaglandins', 'Rats', 'Rats, Inbred Strains', 'Reference Values', 'Thromboxane B2'] | 2,735,953 | [['B01.050'], ['D04.345.566.235', 'D12.644.641.235'], ['E05.481'], ['A05.810.453'], ['A05.810.453.324'], ['A05.810.453.466'], ['D10.251.355.255.550', 'D23.469.050.175.725'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760', 'B01.050.150.900.649.313.992.635.505.700.400'], ['E05.978.810'], ['D10.25... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Impact of pancreaticoduodenal arcade dilation on postoperative outcomes after pancreaticoduodenectomy. | BACKGROUND: The aim of this study was to investigate the impact of pancreaticoduodenal arcade (PDA) dilation on postoperative outcomes after pancreaticoduodenectomy.METHODS: Consecutive patients submitted to pancreaticoduodenectomy between 2008 and 2016 underwent preoperative multi-detector computed tomography, the ima... | ['Adult', 'Aged', 'Aged, 80 and over', 'Dilatation, Pathologic', 'Duodenum', 'Female', 'Humans', 'Male', 'Middle Aged', 'Pancreas', 'Pancreatic Neoplasms', 'Pancreaticoduodenectomy', 'Postoperative Complications', 'Retrospective Studies', 'Tomography, X-Ray Computed', 'Young Adult'] | 28,919,282 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C23.300.325'], ['A03.556.124.684.124', 'A03.556.875.249'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['A03.734'], ['C04.588.274.761', 'C04.588.322.475', 'C06.301.761', 'C06.689.667', 'C19.344.421'], ['E04.210.760'], ['C23.550.... | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Outcomes of Preterm Infants following Discussions about Withdrawal or Withholding of Life Support. | OBJECTIVES: To describe the frequency of postnatal discussions about withdrawal or withholding of life-sustaining therapy (WWLST), ensuing WWLST, and outcomes of infants surviving such discussions. We hypothesized that such survivors have poor outcomes.STUDY DESIGN: This retrospective review included registry data from... | ['Decision Making', 'Female', 'Humans', 'Infant', 'Infant Mortality', 'Infant, Newborn', 'Infant, Premature', 'Life Support Care', 'Male', 'Morbidity', 'Outcome Assessment, Health Care', 'Registries', 'Retrospective Studies', 'Survival Rate', 'Withholding Treatment'] | 28,647,272 | [['F02.463.785.373'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['E05.318.308.985.550.475', 'N01.224.935.698.489', 'N06.850.505.400.975.550.475', 'N06.850.520.308.985.550.475'], ['M01.060.703.520'], ['M01.060.703.520.520'], ['E02.760.440', 'N02.421.585.440'], ['E05.318.308.985.525', 'N01.224.935... | ['Psychiatry and Psychology [F]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Molecular subtyping of Borrelia burgdorferi sensu lato isolates from five patients with solitary lymphocytoma. | Solitary lymphocytoma is a rare cutaneous manifestation of Lyme borreliosis that has been reported almost exclusively from Europe. This suggests that its etiologic agent may be absent or extremely rare on the North American continent. All three species of B. burgdorferi sensu lato known to be associated with human Lyme... | ['Adult', 'Aged', 'Antigens, Surface', 'Bacterial Outer Membrane Proteins', 'Bacterial Vaccines', 'Biopsy', 'Borrelia burgdorferi Group', 'DNA Primers', 'DNA, Bacterial', 'Electrophoresis, Gel, Pulsed-Field', 'Electrophoresis, Polyacrylamide Gel', 'Europe', 'Female', 'Gene Amplification', 'Humans', 'Leukemia, Lymphocyt... | 8,980,295 | [['M01.060.116'], ['M01.060.116.100'], ['D23.050.301'], ['D12.776.097.120', 'D12.776.543.100'], ['D20.215.894.135'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['B03.440.425.410.711.193.150', 'B03.851.595.193.150'], ['D1... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
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