Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Parameters for the RM1 Quantum Chemical Calculation of Complexes of the Trications of Thulium, Ytterbium and Lutetium. | The RM1 quantum chemical model for the calculation of complexes of Tm(III), Yb(III) and Lu(III) is advanced. Subsequently, we tested the models by fully optimizing the geometries of 126 complexes. We then compared the optimized structures with known crystallographic ones from the Cambridge Structural Database. Results ... | ['Lutetium', 'Models, Chemical', 'Quantum Theory', 'Thulium', 'Ytterbium'] | 27,223,475 | [['D01.268.558.362.562', 'D01.268.956.311', 'D01.552.550.399.562'], ['E05.599.495'], ['H01.671.579.800'], ['D01.268.558.362.984', 'D01.552.550.399.984'], ['D01.268.558.362.992', 'D01.552.550.399.992']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
A mathematical model for germinal centre kinetics and affinity maturation. | We present a mathematical model which reproduces experimental data on the germinal centre (GC) kinetics of the primed primary immune response and on affinity maturation observed during the reaction. We show that antigen masking by antibodies which are produced by emerging plasma cells can drive affinity maturation and ... | ['Antibody Affinity', 'Antigens', 'Clone Cells', 'Germinal Center', 'Humans', 'Immunologic Memory', 'Models, Immunological', 'Plasma Cells'] | 12,413,873 | [['G12.040', 'G12.122.125'], ['D23.050'], ['A11.251.353'], ['A10.549.400.500', 'A15.382.520.604.412.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G12.450.050.500'], ['E05.599.395.500'], ['A11.063.438.725', 'A11.118.637.555.567.562.725', 'A15.145.229.637.555.567.562.725', 'A15.382.032.438.725', 'A15.382.490.... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Comparison of a miniaturized shake-flask solubility method with automated potentiometric acid/base titrations and calculated solubilities. | Solubility is one of the most important parameters for lead selection and optimization during drug discovery. Its determination should therefore take place as early as possible in the process. Because of the large numbers of compounds involved and the very low amounts of each compound available in the early development... | ['Algorithms', 'Buffers', 'Chemistry, Pharmaceutical', 'Chromatography, High Pressure Liquid', 'Drug Compounding', 'Glyburide', 'Hydrogen-Ion Concentration', 'Neural Networks, Computer', 'Pharmaceutical Preparations', 'Potentiometry', 'Solubility'] | 15,761,925 | [['G17.035', 'L01.224.050'], ['D27.720.470.280'], ['H01.158.703.007', 'H01.181.466'], ['E05.196.181.400.300'], ['E05.916.270'], ['D02.065.950.828.575', 'D02.886.590.795.575'], ['G02.300'], ['G17.485', 'L01.224.050.375.605'], ['D26'], ['E05.196.922.750', 'E05.301.710'], ['G02.805']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
A modular approach to create a neurovascular unit-on-a-chip. | In this work, we describe the fabrication and working of a modular microsystem that recapitulates the functions of the "Neurovascular Unit". The microdevice comprised a vertical stack of a poly(dimethylsiloxane) (PDMS) neural parenchymal chamber separated by a vascular channel via a microporous polycarbonate (PC) membr... | ['Animals', 'Brain', 'Cell Differentiation', 'Cell Shape', 'Cell Survival', 'Cells, Cultured', 'Coculture Techniques', 'Endothelial Cells', 'Microfluidic Analytical Techniques', 'Microvessels', 'Neurons', 'Rats'] | 23,108,480 | [['B01.050'], ['A08.186.211'], ['G04.152'], ['G04.320'], ['G04.346'], ['A11.251'], ['E05.481.500.374'], ['A11.436.275'], ['E05.588.465'], ['A07.015.461'], ['A08.675', 'A11.671'], ['B01.050.150.900.649.313.992.635.505.700']] | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Regulators of G-protein signaling 2 and 4 differentially regulate cocaine-induced rewarding effects. | There is a need to identify new therapeutic targets for the treatment of cocaine addiction due to the rise in cocaine abuse and deaths due to cocaine overdose. Regulator of G protein signaling (RGS) proteins such as RGS2 and RGS4 are widely distributed in brain regions that play a role in drug reward. Importantly, RGS2... | ['Animals', 'Cocaine', 'Cocaine-Related Disorders', 'Conditioning, Psychological', 'Dopamine Uptake Inhibitors', 'Female', 'Male', 'Mice, Knockout', 'Motor Activity', 'RGS Proteins', 'Reward', 'Sex Factors', 'Spatial Behavior'] | 30,036,561 | [['B01.050'], ['D02.145.074.722.388', 'D03.132.889.354', 'D03.605.084.500.722.388', 'D03.605.869.388'], ['C25.775.300', 'F03.900.300'], ['F02.463.425.179'], ['D27.505.519.562.437.220', 'D27.505.519.625.150.800', 'D27.505.519.625.600.220', 'D27.505.696.577.150.800', 'D27.505.696.577.600.220'], ['B01.050.050.136.500.500'... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Macular pigment density in monozygotic twins. | PURPOSE: Research shows wide variation in macular pigment density between individuals. As are other ocular pigments, this variation may be genetic. To test this hypothesis, the authors measured macular pigment density, serum carotenoid concentrations, and general dietary patterns in 10 pairs of identical twins.METHODS:... | ['Adult', 'Carotenoids', 'Chromatography, High Pressure Liquid', 'Diet Surveys', 'Feeding Behavior', 'Female', 'Humans', 'Macula Lutea', 'Male', 'Psychophysics', 'Retinal Pigments', 'Spectrophotometry', 'Twins, Monozygotic'] | 7,591,643 | [['M01.060.116'], ['D02.455.326.271.665.202', 'D02.455.426.392.368.367.379.249', 'D02.455.849.131', 'D23.767.261'], ['E05.196.181.400.300'], ['E05.318.308.980.485.350', 'N05.715.360.300.800.469.300', 'N06.850.505.616.300', 'N06.850.520.308.980.469.350'], ['F01.145.113.547', 'F01.145.407', 'G07.203.650.353'], ['B01.050.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Embryonic stem cell therapy in experimental stroke: host-dependent malignant transformation]. | INTRODUCTION: Therapeutic application of embryonic stem cells in neurodegenerative disorders like stroke is widely investigated in preclinical animal models.AIM: The authors studied the therapeutic potential of murine embryonic stem cells in two rodent models of stroke.METHODS: Undifferentiated and predifferentiated st... | ['Animals', 'Blotting, Western', 'Brain', 'Brain Neoplasms', 'Disease Models, Animal', 'Embryo, Mammalian', 'Immunohistochemistry', 'Mice', 'Rats', 'Stem Cell Transplantation', 'Stroke', 'Teratocarcinoma', 'Time Factors', 'Transplantation, Heterologous', 'Transplantation, Homologous'] | 15,285,148 | [['B01.050'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['A08.186.211'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['A16.254'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.5... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Prenatal ethanol exposure impairs spatial cognition and synaptic plasticity in female rats. | Chronic prenatal ethanol exposure (CPEE) can impair long-term potentiation (LTP) in the male hippocampus. Sexually specific alterations were frequently reported in female animals that had been prenatally exposed to ethanol. This study aimed to examine the effects of CPEE on spatial learning and memory, as well as on hi... | ['Animals', 'Cognition', 'Cognition Disorders', 'Ethanol', 'Female', 'Maze Learning', 'Neuronal Plasticity', 'Pregnancy', 'Prenatal Exposure Delayed Effects', 'Rats', 'Rats, Wistar'] | 26,251,263 | [['B01.050'], ['F02.463.188'], ['F03.615.250'], ['D02.033.375'], ['F02.463.425.874.500'], ['G11.561.638'], ['G08.686.784.769'], ['C13.703.824.500'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.900']] | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Hospitalization for pneumonia in the Cardiovascular Health Study: incidence, mortality, and influence on longer-term survival. | OBJECTIVES: To estimate the rate of hospitalization for pneumonia in community-dwelling older adults and to assess its risk factors and contribution to mortality.DESIGN: Prospective observational study.SETTING: The Cardiovascular Health Study (CHS) in four U.S. communities.PARTICIPANTS: Five thousand eight hundred eigh... | ['Aged', 'Aged, 80 and over', 'Cognition', 'Comorbidity', 'Diabetes Complications', 'Female', 'Hospitalization', 'Humans', 'Male', 'Mortality', 'Pneumonia', 'Prospective Studies', 'Respiratory Physiological Phenomena', 'Risk Factors', 'Smoking'] | 16,108,926 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['F02.463.188'], ['N05.715.350.225', 'N06.850.490.687'], ['C19.246.099'], ['E02.760.400', 'N02.421.585.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.550', 'N01.224.935.698', 'N06.850.505.400.975.550', 'N06.850.520.308.985.550'], ['C01.748.610', ... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Using a TightRope® to treat a complex fracture of the trapezium. | We present the case of a 23-year-old man with a combined scaphoid fracture and comminuted trapezium fracture, treated surgically with percutaneous fixation of the scaphoid fracture and concomitant Arthrex Mini TightRope(®) stabilisation of base of thumb metacarpal to base of index finger metacarpal. The patient made a ... | ['Accidents, Traffic', 'Bone Screws', 'Bone Wires', 'Carpometacarpal Joints', 'Fracture Fixation, Internal', 'Fractures, Bone', 'Fractures, Comminuted', 'Humans', 'Male', 'Minimally Invasive Surgical Procedures', 'Motorcycles', 'Radiography', 'Range of Motion, Articular', 'Recovery of Function', 'Scaphoid Bone', 'Trape... | 25,245,724 | [['N06.850.135.392'], ['E07.695.370.437', 'E07.858.442.660.460.437', 'E07.858.690.725.460.437'], ['E07.695.370.468', 'E07.858.442.660.460.468', 'E07.858.690.725.460.468'], ['A02.835.583.405.200'], ['E04.555.300.300'], ['C26.404'], ['C26.404.186'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.502'], ['J01.937.... | ['Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Named Groups [M]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
The effects of parts, wholes, and familiarity on face-selective responses in MEG. | Although face perception is commonly characterized as holistic, as opposed to part-based, we have recently shown that both face parts and wholes are represented in "face-selective" cortical regions, with greater adaptation of holistic representations for familiar faces (A. Harris & G. K. Aguirre, 2008). Here we investi... | ['Adolescent', 'Adult', 'Cues', 'Face', 'Field Dependence-Independence', 'Humans', 'Magnetoencephalography', 'Pattern Recognition, Visual', 'Photic Stimulation', 'Recognition, Psychology', 'Time Factors', 'Vision Disparity', 'Visual Cortex'] | 19,146,346 | [['M01.060.057'], ['M01.060.116'], ['F02.463.425.234'], ['A01.456.505'], ['F02.463.593.343'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.376.500', 'E01.370.405.440', 'E05.540.500'], ['F02.463.593.524.500', 'F02.463.593.932.622'], ['E05.723.729'], ['F02.463.425.540.706'], ['G01.910.857'], ['F02.463.593.7... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Perioperative restrictive versus goal-directed fluid therapy for adults undergoing major non-cardiac surgery. | BACKGROUND: Perioperative fluid management is a crucial element of perioperative care and has been studied extensively recently; however, 'the right amount' remains uncertain. One concept in perioperative fluid handling is goal-directed fluid therapy (GDFT), wherein fluid administration targets various continuously mea... | ['Fluid Therapy', 'Humans', 'Length of Stay', 'Perioperative Care', 'Postoperative Complications', 'Randomized Controlled Trials as Topic', 'Surgical Procedures, Operative'] | 31,829,446 | [['E02.319.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.760.400.480', 'N02.421.585.400.480'], ['E02.760.731', 'E04.604', 'N02.421.585.722'], ['C23.550.767'], ['E05.318.372.250.250.365.500', 'N05.715.360.330.250.250.365.500', 'N06.850.520.450.250.250.365.500'], ['E04']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Enhancement of phase separation by the addition of de-emulsifiers to three-phase (diesel oil/biocatalyst/aqueous phase) emulsion in diesel biodesulfurization. | Ethanol, added as a de-emulsifier to separate oil and biocatalyst (or bacterial cells) from a three-phase (oil/biocatalyst/aqueous phase) emulsion, formed in diesel biodesulfurization employing Gordonia nitida, improved oil recovery by centrifugation from about 50% in its absence to almost 100% at 3% (v/v). The biocata... | ['Actinomycetales', 'Air Pollution', 'Biodegradation, Environmental', 'Bioreactors', 'Catalysis', 'Cell Culture Techniques', 'Centrifugation', 'Culture Media', 'Emulsions', 'Ethanol', 'Excipients', 'Gasoline', 'Petroleum', 'Quality Control', 'Sulfur', 'Sulfur Compounds', 'Surface Tension', 'Viscosity'] | 12,882,310 | [['B03.510.024.049'], ['N06.850.460.100'], ['N06.230.080.600.500', 'N06.850.460.375.500'], ['E07.115', 'J01.897.120.115'], ['G02.130'], ['E01.370.225.500.223', 'E05.200.500.265', 'E05.242.223', 'E05.481.500.249'], ['E05.181'], ['D27.720.470.305', 'E07.206'], ['D20.280.260', 'D26.255.165.260'], ['D02.033.375'], ['D26.65... | ['Organisms [B]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Pestalotiopsis-Like Species Causing Gray Blight Disease on Camellia sinensis in China. | Gray blight of tea, caused by several Pestalotiopsis-like species, is one of the most destructive foliar diseases in tea cultivation yet the characteristics of these pathogens have not been confirmed until now. With morphological and multigene phylogenetic analyses, we have identified the gray blight fungi as Pseudopes... | ['Bacterial Proteins', 'Camellia sinensis', 'China', 'Phylogeny', 'Plant Diseases', 'RNA, Bacterial', 'Sequence Analysis, DNA', 'Xylariales'] | 30,673,469 | [['D12.776.097'], ['B01.650.940.800.575.912.250.341.998.500.500'], ['Z01.252.474.164'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['G15.610'], ['D13.444.735.473'], ['E05.393.760.700'], ['B01.300.107.950']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 |
Competition between the GlnR and PhoP regulators for the glnA and amtB promoters in Streptomyces coelicolor. | Interaction of regulatory networks is a subject of great interest in systems biology of bacteria. Phosphate control of metabolism in Streptomyces is mediated by the two-component system PhoR-PhoP. Similarly, the utilization of different nitrogen sources is controlled by the regulator GlnR. Transcriptomic and biochemica... | ['Bacterial Proteins', 'Binding Sites', 'Binding, Competitive', 'Cation Transport Proteins', 'Glutamate-Ammonia Ligase', 'Mutagenesis', 'Nitrogen', 'Operator Regions, Genetic', 'Promoter Regions, Genetic', 'Streptomyces coelicolor', 'Trans-Activators'] | 23,248,009 | [['D12.776.097'], ['G02.111.570.120'], ['E05.196.080', 'G02.111.084', 'G02.111.570.120.309'], ['D12.776.157.530.450.250', 'D12.776.543.585.450.250'], ['D08.811.464.259.200.600'], ['G05.558'], ['D01.268.604', 'D01.362.625'], ['G02.111.570.080.689.650', 'G05.360.080.689.650', 'G05.360.340.024.686.645', 'G05.360.340.358.2... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Making the nursing curriculum more inclusive for students with specific learning difficulties (SpLD): embedding specialist study skills into a core module. | BACKGROUND: Wray et al. (2012) found that providing specialist 'add on' study skills sessions to students with SpLD increased the likelihood of progression and earlier identification. However, 48% of students identified as 'at risk' of having a SpLD did not pursue further assessment/support, which is of concern. OBJECT... | ['Adult', 'Cohort Studies', 'Curriculum', 'Education, Nursing, Baccalaureate', 'England', 'Female', 'Humans', 'Interprofessional Relations', 'Learning Disabilities', 'Mainstreaming, Education', 'Male', 'Personal Satisfaction', 'Students, Nursing', 'Writing', 'Young Adult'] | 22,863,211 | [['M01.060.116'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['I02.158'], ['I02.358.462.316'], ['Z01.542.363.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.401.205'], ['C10.597.606.150.550', 'C23.888.592.604.150.550', 'F03.625.562'], ['I02.158.600', 'I02.233.213.60... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Information Science [L]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
Cost-effectiveness of medical expulsive therapy using alpha-blockers for the treatment of distal ureteral stones. | OBJECTIVE: Medical expulsive therapy (MET) has recently emerged as an efficacious and safe option for the initial management of ureteral stones. The objective of this study was to assess the cost-effectiveness of MET compared with conservative therapy for the treatment of ureteral stones using international cost data f... | ['Adrenergic alpha-Antagonists', 'Cost-Benefit Analysis', 'Female', 'Germany', 'Humans', 'Incidence', 'Italy', 'Male', 'Observation', 'Sulfonamides', 'Tamsulosin', 'Turkey', 'United Kingdom', 'United States', 'Ureteral Calculi'] | 17,889,988 | [['D27.505.519.625.050.200.100', 'D27.505.696.577.050.200.100'], ['N03.219.151.125'], ['Z01.542.315'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.985.525.375'], ['Z01.542.489'], ['E05.581.249'], ['D02.065.884', 'D02... | ['Chemicals and Drugs [D]', 'Health Care [N]', 'Geographicals [Z]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
[Characteristics of hospital care and its relationship to severe maternal morbidity in Medell?n, Colombia]. | OBJECTIVE: The objective of this study was to determine whether there is an association between severe maternal mortality (SMM) and the characteristics of access to and use of obstetric services by the participating women.METHODS: A study of cases and controls was conducted in a group of 600 women who were attended dur... | ['Adult', 'Case-Control Studies', 'Colombia', 'Female', 'Health Services Accessibility', 'Hospitalization', 'Humans', 'Maternal Health Services', 'Maternal Mortality', 'Pregnancy', 'Pregnancy Complications', 'Surveys and Questionnaires'] | 24,626,443 | [['M01.060.116'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['Z01.107.757.284'], ['N04.590.374.350', 'N05.300.430'], ['E02.760.400', 'N02.421.585.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N02.421.143.620', 'N02.421.800.500'], ['E05.318.308.985.550.500', 'N01.224.935.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Cardiovascular Safety of Tocilizumab Versus Tumor Necrosis Factor Inhibitors in Patients With Rheumatoid Arthritis: A Multi-Database Cohort Study. | OBJECTIVE: While tocilizumab (TCZ) is known to increase low-density lipoprotein (LDL) cholesterol levels, it is unclear whether TCZ increases cardiovascular risk in patients with rheumatoid arthritis (RA). This study was undertaken to compare the cardiovascular risk associated with receiving TCZ versus tumor necrosis f... | ['Adult', 'Aged', 'Antibodies, Monoclonal, Humanized', 'Antirheumatic Agents', 'Arthritis, Rheumatoid', 'Cardiovascular Diseases', 'Cohort Studies', 'Databases, Factual', 'Drug Substitution', 'Female', 'Hospitalization', 'Humans', 'Incidence', 'Male', 'Middle Aged', 'Myocardial Infarction', 'Propensity Score', 'Proport... | 28,245,350 | [['M01.060.116'], ['M01.060.116.100'], ['D12.776.124.486.485.114.224.060', 'D12.776.124.790.651.114.224.060', 'D12.776.377.715.548.114.224.200'], ['D27.505.954.329'], ['C05.550.114.154', 'C05.799.114', 'C17.300.775.099', 'C20.111.199'], ['C14'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.75... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Information Science [L]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
EphrinB2/EphB4 inhibition in the osteoblast lineage modifies the anabolic response to parathyroid hormone. | Previous reports indicate that ephrinB2 expression by osteoblasts is stimulated by parathyroid hormone (PTH) and its related protein (PTHrP) and that ephrinB2/EphB4 signaling between osteoblasts and osteoclasts stimulates osteoblast differentiation while inhibiting osteoclast differentiation. To determine the role of t... | ['Anabolic Agents', 'Animals', 'Biomarkers', 'Cell Count', 'Cell Lineage', 'Cells, Cultured', 'Ephrin-B2', 'Femur', 'Humans', 'Male', 'Mice, Inbred C57BL', 'Organ Size', 'Osteoblasts', 'Osteocytes', 'Parathyroid Hormone', 'RANK Ligand', 'RNA, Messenger', 'Receptor, EphB4', 'Skull', 'Solubility'] | 23,165,727 | [['D27.505.696.399.472.080'], ['B01.050'], ['D23.101'], ['E01.370.225.500.195', 'E05.200.500.195', 'E05.242.195', 'G04.140'], ['G04.172', 'G07.345.500.325.180.500', 'G08.686.155', 'G08.686.784.170.104.249'], ['A11.251'], ['D12.644.276.500.700', 'D12.776.467.500.700', 'D12.776.543.287.700', 'D23.529.500.700'], ['A02.835... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The erythroid niche: molecular processes occurring within erythroblastic islands. | Erythroblasts terminally differentiate within specialized niches composed of erythroblast islands nesting in extracellular matrix proteins. A number of adhesion molecules active in erythroid island attachments have been identified. We have recently observed a receptor/counter receptor interaction that appears to mainta... | ['Animals', 'Cell Adhesion Molecules', 'Cell Differentiation', 'Elliptocytosis, Hereditary', 'Erythroblasts', 'Erythrocyte Membrane', 'Erythrocytes', 'Erythropoiesis', 'Fibronectins', 'Laminin', 'Mice', 'Mice, Knockout', 'Reticulocytes', 'Spherocytosis, Hereditary'] | 20,655,267 | [['B01.050'], ['D12.776.395.550.200', 'D12.776.543.550.200', 'D23.050.301.350'], ['G04.152'], ['C15.378.071.141.150.365', 'C16.320.070.365'], ['A11.148.378.590.837.250.200', 'A11.443.240.497.200', 'A15.378.316.378.590.837.250.200'], ['A11.118.290.270', 'A11.284.149.356', 'A15.145.229.334.270'], ['A11.118.290', 'A11.443... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Development of a delayed-release nutrient for appetite control in adults with obesity and type 2 diabetes and initial clinical testing in a single dose randomized controlled trial. | BACKGROUND AND OBJECTIVES: Delivery of nutrients directly to the small intestine, either via enteral feeding tube or by gastric bypass surgery, is associated with increased levels of appetite-suppressing and glucoregulatory hormones, including GLP-1, and reduced appetite. Achieving these changes non-invasively using fo... | ['Adult', 'Appetite', 'Appetite Regulation', 'Blood Glucose', 'C-Peptide', 'Cross-Over Studies', 'Diabetes Mellitus, Type 2', 'Dietary Supplements', 'Energy Intake', 'Female', 'Glucagon-Like Peptide 1', 'Humans', 'Insulin', 'Male', 'Middle Aged', 'Obesity', 'Pilot Projects', 'Prospective Studies'] | 31,308,360 | [['M01.060.116'], ['F02.830.071', 'G07.203.650.390.070', 'G10.261.390.070'], ['G07.203.650.170', 'G07.203.650.390.070.290', 'G10.261.390.070.290'], ['D09.947.875.359.448.500'], ['D06.472.699.587.200.500.250', 'D12.644.548.586.200.500.250'], ['E05.318.370.150', 'N05.715.360.325.150', 'N06.850.520.445.150'], ['C18.452.39... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Anaplasmosis: experimental immunodeficient state model. | OBJECTIVE: Introduction: The recently described anaplasmosis infection is widespread but concerns to the insufficiently known group of diseases. The aim of our research is the development of uniform biological model for reproducing of artificial immunodeficient state by experimental anaplasmosis.PATIENTS AND METHODS: M... | ['Anaplasmosis', 'Animals', 'Disease Models, Animal', 'Mice'] | 31,622,262 | [['C01.150.252.400.054.500', 'C01.150.252.400.082', 'C01.920.930.163', 'C22.085'], ['B01.050'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['B01.050.150.900.649.313.992.635.505.500']] | ['Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Management strategy for multifocal branch duct intraductal papillary mucinous neoplasms of the pancreas. | OBJECTIVES: Branch duct intraductal papillary mucinous neoplasms of the pancreas (BD-IPMNs) often are composed of multifocal lesions. We aimed to clarify the clinicopathologic features of multifocal BD-IPMNs.METHODS: Medical records of 211 patients with BD-IPMNs (169 solitary and 42 multifocal) were retrospectively ana... | ['Adenocarcinoma, Mucinous', 'Adenocarcinoma, Papillary', 'Adult', 'Aged', 'Aged, 80 and over', 'Carcinoma, Pancreatic Ductal', 'Female', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Neoplasm Invasiveness', 'Pancreatectomy', 'Pancreatic Neoplasms', 'Prognosis', 'Survival Rate', 'Treatment Outcome'] | 22,850,621 | [['C04.557.470.200.025.075', 'C04.557.470.590.075'], ['C04.557.470.200.025.085'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C04.557.470.200.025.232.750', 'C04.557.470.615.132.750', 'C04.588.274.761.750', 'C04.588.322.475.750', 'C06.301.761.750', 'C06.689.667.625', 'C19.344.421.750'], ['B01.050.15... | ['Diseases [C]', 'Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Treatment of reoccurring instent restenosis following reintervention after stent-supported renal artery angioplasty. | BACKGROUND: Reoccurrence of restenosis following angioplasty of renal instent restenosis is a considerable drawback of stent-supported angioplasty of renal artery stenosis especially in small vessel diameters. We therefore prospectively studied the long-term outcome of different techniques of endovascular treatment of ... | ['Adult', 'Aged', 'Angioplasty, Balloon', 'Cardiovascular Agents', 'Feasibility Studies', 'Female', 'Follow-Up Studies', 'Humans', 'Kaplan-Meier Estimate', 'Male', 'Metals', 'Middle Aged', 'Proportional Hazards Models', 'Prospective Studies', 'Prosthesis Design', 'Recurrence', 'Registries', 'Renal Artery', 'Renal Arter... | 17,630,674 | [['M01.060.116'], ['M01.060.116.100'], ['E02.148.050.060', 'E04.100.814.529.124.060', 'E04.502.382.124.060', 'E05.157.016.060'], ['D27.505.954.411'], ['E05.318.372.550', 'E05.337.675', 'N05.715.360.330.550', 'N06.850.520.450.550'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Impaired insulin signaling affects renal organic anion transporter 3 (Oat3) function in streptozotocin-induced diabetic rats. | Organic anion transporter 3 (Oat3) is a major renal Oats expressed in the basolateral membrane of renal proximal tubule cells. We have recently reported decreases in renal Oat3 function and expression in diabetic rats and these changes were recovered after insulin treatment for four weeks. However, the mechanisms by wh... | ['Animals', 'Diabetes Mellitus, Experimental', 'Insulin', 'Kidney', 'Male', 'Organic Anion Transporters, Sodium-Independent', 'Protein Kinase Inhibitors', 'Rats', 'Rats, Wistar', 'Signal Transduction'] | 24,801,871 | [['B01.050'], ['C18.452.394.750.074', 'C19.246.240', 'E05.598.500.374'], ['D06.472.699.587.200.500.625', 'D12.644.548.586.200.500.625'], ['A05.810.453'], ['D12.776.157.530.450.074.500.781', 'D12.776.543.585.450.074.500.875'], ['D27.505.519.389.755'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.31... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Climacteric arthralgia and hand arthrosis]. | This study aimed at a possible classification of climacteric arthroses of the hand. 132 females suffering from arthralgias of the wrist and finger joints who had consulted our outpatient department originally because of climacteric complaints, were examined while asking them to complete a questionnaire with clinical cr... | ['Aged', 'Arthralgia', 'Climacteric', 'Diagnosis, Differential', 'Female', 'Finger Joint', 'Hand Deformities, Acquired', 'Humans', 'Middle Aged', 'Osteoarthritis', 'Radiography', 'Range of Motion, Articular'] | 8,707,044 | [['M01.060.116.100'], ['C05.550.091', 'C23.888.592.612.094', 'F02.830.816.444.350', 'G11.561.790.444.350'], ['G08.686.157', 'G08.686.841.249'], ['E01.171'], ['A02.835.583.405.350'], ['C05.390.110'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C05.550.114.606', 'C05.799.613'], ['E01.370.350.7... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Inhibition of electron flow through complex I of the mitochondrial respiratory chain of Ehrlich ascites carcinoma cells by methylglyoxal. | The effect of methylglyoxal on the oxygen consumption of Ehrlich-ascites-carcinoma (EAC)-cell mitochondria was tested by using different respiratory substrates, electron donors at different segments of the mitochondrial respiratory chain and site-specific inhibitors to identify the specific respiratory complex which mi... | ['Aldehydes', 'Animals', 'Carcinoma, Ehrlich Tumor', 'Electron Transport', 'Hydroquinones', 'Ketoglutaric Acids', 'Kinetics', 'Malonates', 'Mice', 'Mitochondria', 'NAD(P)H Dehydrogenase (Quinone)', 'Oxygen Consumption', 'Pyruvaldehyde'] | 7,945,267 | [['D02.047'], ['B01.050'], ['C04.557.470.200.200', 'C04.619.169'], ['G02.111.248', 'G03.295.531.403', 'G03.493.350'], ['D02.455.426.559.389.657.393'], ['D02.241.081.337.351.502', 'D02.241.755.465'], ['G01.374.661', 'G02.111.490'], ['D02.241.081.337.540'], ['B01.050.150.900.649.313.992.635.505.500'], ['A11.284.430.214.1... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Hemagglutination with avian infectious laryngotracheitis virus. | Avian infectious laryngotracheitis virus grown in primary chicken kidney cell cultures was tested for hemagglutination (HA) with erythrocytes of a variety of species at 4 degrees C, 22 degrees C, and 37 degrees C. HA was observed at all temperatures with mouse erythrocytes but not with cattle, sheep, goat, swine, rabbi... | ['Animals', 'Cells, Cultured', 'Chickens', 'Guinea Pigs', 'Hemagglutination Inhibition Tests', 'Hemagglutination Tests', 'Hemagglutination, Viral', 'Herpesvirus 1, Gallid', 'Mice', 'Neutralization Tests'] | 2,171,463 | [['B01.050'], ['A11.251'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['B01.050.150.900.649.313.992.550'], ['E01.370.225.812.735.370', 'E05.200.812.735.370', 'E05.478.594.760.370'], ['E01.370.225.812.735.050.375', 'E05.200.812.735.050.375', 'E05.478.594.760.050.375'], ['G02.111.026.500.500', 'G06.9... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cbl-b accelerates trypsin-induced cell detachment through ubiquitination and degradation of proline-rich tyrosine kinase 2. | Trypsin is a digestive enzyme that is widely used for cell detachment, which is the first stage of tumor metastasis. Recent studies show that adhesion-related kinases are involved in cell detachment. Proline-rich tyrosine kinase 2 (Pyk2) is a crucial kinase in the regulation of cell adhesion and detachment. However, th... | ['Apoptosis', 'Blotting, Western', 'Cell Adhesion', 'Cell Proliferation', 'Focal Adhesion Kinase 2', 'Humans', 'Immunoprecipitation', 'Neoplasms', 'Phosphorylation', 'Proteolysis', 'Proto-Oncogene Proteins c-cbl', 'RNA, Small Interfering', 'Trypsin', 'Tumor Cells, Cultured', 'Ubiquitination'] | 25,099,615 | [['G04.146.954.035'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['G04.022'], ['G04.161.750', 'G07.345.249.410.750'], ['D08.811.913.696.620.682.725.049.750', 'D23.050.301.500.600.350', 'D23.050.705.552.600.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ... | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Prooxidant-antioxidant balance and cardiac function in patients with cardiovascular disease following cardiac surgery. | BACKGROUND AND AIM OF THE STUDY: Cardiopulmonary bypass (CPB) is used during on-pump coronary artery bypass grafting (CABG) and heart valvular replacement surgery, and is associated with the induction of oxidative stress. The aim of the study was to assess the association between indices of cardiac function and prooxid... | ['Aged', 'Antioxidants', 'Benzidines', 'Cardiopulmonary Bypass', 'Cardiovascular Diseases', 'Chromogenic Compounds', 'Coronary Artery Bypass', 'Female', 'Heart Function Tests', 'Heart Valve Prosthesis Implantation', 'Humans', 'Male', 'Middle Aged', 'Oxidants', 'Oxidative Stress', 'Postoperative Care', 'Preoperative Car... | 24,151,768 | [['M01.060.116.100'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['D02.455.426.559.389.185.100'], ['E04.292.413'], ['C14'], ['D27.720.233.174', 'D27.720.470.410.200'], ['E04.100.376.719.332', 'E04.100.814.868.750', 'E04.928.220.520.220'], ['E01.370.370.380'], ['E04.100.376.485', 'E04.650.410', 'E04.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
The effect of ischemia and reperfusion on mitochondrial contact sites in isolated rat hearts. | Contact sites may be described as energy channels between the mitochondria and the cytosol, created by fusion of the inner and the outer mitochondrial membranes, and their number depends highly on the energy state of the cell. The aim of the present study was to examine the early changes of ischemia and reperfusion on ... | ['Animals', 'Blood Pressure', 'Female', 'Heart Rate', 'In Vitro Techniques', 'Membranes', 'Mitochondria, Heart', 'Myocardial Contraction', 'Myocardial Ischemia', 'Myocardial Reperfusion Injury', 'Myocardium', 'Rats', 'Rats, Wistar', 'Ventricular Function, Left'] | 7,599,437 | [['B01.050'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E01.370.600.875.500', 'G09.330.380.500'], ['E05.481'], ['A10.615'], ['A11.284.430.214.190.875.564.627.603', 'A11.284.835.626.627.603'], ['G09.330.580', 'G11.427.494.570'], ['C14.280.647', 'C14.907.585'], ['C14.280.238.615', 'C14.280.647.625', 'C14.907.585.625'... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Rapid radiofrequency calibration in MRI. | A collection of modified procedures for setting rf transmitter levels using a three-pulse sequence is described. Based on a geometrically weighted ratio of four signals, an estimate of the flip angle is calculated and used for an updating prescription. These techniques are designed to perform rapidly yet eschew systema... | ['Algorithms', 'Calibration', 'Humans', 'Magnetic Resonance Imaging', 'Radio Waves'] | 2,233,222 | [['G17.035', 'L01.224.050'], ['E05.978.155'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['G01.358.500.505.810', 'G01.750.250.810', 'G01.750.770.721']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
[Effect of Tongfeng trace elements nutrient balance agent on growth, physiological characteristics and content of active constituents of Glycyrrhiza uralensis]. | OBJECTIVE: To investigate the effects of Tongfeng trace elements nutrient balance agent on the various growth indicators, physiological indicators, and the contents of liquiritin and glycyrrhizic acid in one-year old Glycyrrhiza uralensis.METHOD: The plants of G. uralensis growing in Chifeng of Inner Mongolia and medic... | ['Enzyme Activation', 'Fertilizers', 'Flavanones', 'Glucosides', 'Glycyrrhiza uralensis', 'Glycyrrhizic Acid', 'Oxidoreductases', 'Photosynthesis', 'Trace Elements'] | 22,066,433 | [['G02.111.263', 'G03.328'], ['D27.720.031.400'], ['D03.383.663.283.266.450.252', 'D03.633.100.150.266.450.252'], ['D09.408.348'], ['B01.650.940.800.575.912.250.401.300.500'], ['D02.455.849.919.530.466'], ['D08.811.682'], ['G02.111.158.937', 'G02.111.669.700', 'G02.740.921', 'G03.191.937', 'G03.493.700', 'G03.800.700',... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
CRISPR tracking reveals global spreading of antimicrobial resistance genes by Staphylococcus of canine origin. | The close contact between pets and their owners is a potential source for microorganisms and genetic material exchange. Staphylococcus species considered as harmless inhabitants of animals' and humans' microbiota can act as reservoirs of antimicrobial resistance genes to more virulent species, thereby increasing their ... | ['Animals', 'Clustered Regularly Interspaced Short Palindromic Repeats', 'Disease Reservoirs', 'Dogs', 'Drug Resistance, Bacterial', 'Gene Transfer, Horizontal', 'Genome, Bacterial', 'Humans', 'Methicillin Resistance', 'Microbial Sensitivity Tests', 'Pets', 'Plasmids', 'Staphylococcal Infections', 'Staphylococcus'] | 31,030,846 | [['B01.050'], ['G02.111.570.080.708.800.325.500', 'G05.360.080.708.800.325.500', 'G05.360.340.024.850.069'], ['N06.850.520.203.250'], ['B01.050.150.900.649.313.750.250.216.200'], ['G06.099.225', 'G06.225.347', 'G07.690.773.984.269.347'], ['G05.728.390'], ['G05.360.340.358.207'], ['B01.050.150.900.649.313.988.400.112.40... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
The conserved glutamine-rich region of chick csal1 and csal3 mediates protein interactions with other spalt family members. Implications for Townes-Brocks syndrome. | Members of the spalt family of zinc finger-containing proteins have been implicated in development and disease. However, very little is known about the molecular function of spalt proteins. We have used biochemical approaches to characterize functional domains of two chick spalt homologs, csal1 and csal3. We show that ... | ['Amino Acid Sequence', 'Animals', 'Cell Line', 'Chick Embryo', 'Conserved Sequence', 'Disease Models, Animal', 'Extremities', 'Glutamine', 'Homeodomain Proteins', 'Humans', 'Molecular Sequence Data', 'Morphogenesis', 'Peptide Fragments', 'Protein Isoforms', 'Recombinant Proteins', 'Syndrome', 'Transcription Factors', ... | 12,482,848 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['A11.251.210'], ['A13.350.150', 'A16.331.200'], ['G02.111.570.580'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['A01.378'], ['D12.125.068.330', 'D12.125.095.461', 'D12.125.154.424'], ['D12.776.260.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Inhibition of spinal protein kinase C-epsilon or -gamma isozymes does not affect halothane minimum alveolar anesthetic concentration in rats. | Anesthetic effects on receptor or ion channel phosphorylation by enzymes such as protein kinase C (PKC) have been postulated to underlie some aspects of anesthesia. In vitro studies show that anesthetic effects on several receptors are mediated by PKC. To test the importance of PKC for the immobility produced by inhale... | ['Aging', 'Anesthetics, Inhalation', 'Animals', 'Enzyme Inhibitors', 'Halothane', 'Injections, Spinal', 'Protein Kinase C', 'Protein Kinase C-epsilon', 'Pulmonary Alveoli', 'Rats', 'Rats, Sprague-Dawley', 'Spinal Cord'] | 15,281,508 | [['G07.345.124'], ['D27.505.696.277.100.035.060', 'D27.505.954.427.210.100.035.060'], ['B01.050'], ['D27.505.519.389'], ['D02.455.526.340'], ['E02.319.267.530.580'], ['D08.811.913.696.620.682.700.725'], ['D08.811.913.696.620.682.700.725.750'], ['A04.411.715'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
One-Step Assembly of TiO2 | There is a growing interest in the use of hybrid liposomes for various biochemical and biomedical applications. In this study, we report the first preparation and characterization of a class of TiO2-reinforced liposomes by a one-step assembly approach. The amphiphilic natural structure of lipids is exploited to localiz... | ['Hydrophobic and Hydrophilic Interactions', 'Lipid Bilayers', 'Liposomes', 'Microscopy, Electron, Scanning', 'Nanostructures', 'Spectrometry, X-Ray Emission', 'Titanium'] | 31,066,285 | [['G02.409'], ['D10.570.510', 'J01.637.087.500.510'], ['D25.479.517', 'D26.255.260.517', 'J01.637.051.479.517', 'J01.637.087.500.517'], ['E01.370.350.515.402.541', 'E05.595.402.541'], ['J01.637.512'], ['E05.196.867.800', 'E05.799.830'], ['D01.268.557.800', 'D01.268.956.878', 'D01.552.547.800']] | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Radical prostatectomy for clinically localized prostate cancer: local tumor extension and prognosis. | BACKGROUND: This study was performed to evaluate the frequency of local tumor extension and its effect on disease progression after radical prostatectomy.METHODS: The study consisted of 66 consecutive men who underwent radical prostatectomy for clinically localized prostate cancer without any prior hormonal therapy. Ca... | ['Aged', 'Aged, 80 and over', 'Disease Progression', 'Follow-Up Studies', 'Humans', 'Lymphatic Metastasis', 'Male', 'Middle Aged', 'Neoplasm Invasiveness', 'Neoplasm Recurrence, Local', 'Prognosis', 'Prostatectomy', 'Prostatic Neoplasms', 'Retrospective Studies'] | 8,886,914 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['C23.550.291.656'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.697.650.560', 'C23.550.727.650.560'], ['M01.060.116.630'], ['C04.697.645', 'C23.550.727.645'], ['C04.697.6... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Feasibility of using recombinant factor VIIa in continuous infusion. | Recombinant factor VIIa (rFVIIa; NovoSeven) is a recent addition to the hemostatic alternatives for the treatment of hemophiliacs with inhibitors. A drawback in the use of rFVIIa has been its half-life of only about 2 h, which necessitates very frequent and punctual injections. We evaluated the stability of reconstitut... | ['Drug Stability', 'Drug Therapy, Combination', 'Factor VIIa', 'Feasibility Studies', 'Half-Life', 'Hemophilia A', 'Hemostatics', 'Heparin', 'Humans', 'Infusion Pumps', 'Injections, Intravenous', 'Recombinant Proteins', 'Sterilization', 'Treatment Outcome'] | 8,701,403 | [['E05.916.330'], ['E02.319.310'], ['D08.811.277.656.300.760.300', 'D08.811.277.656.959.350.300', 'D12.776.124.125.325.300', 'D23.119.325.300'], ['E05.318.372.550', 'E05.337.675', 'N05.715.360.330.550', 'N06.850.520.450.550'], ['G01.910.405'], ['C15.378.100.100.500', 'C15.378.100.141.500', 'C15.378.463.500', 'C16.320.0... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Purification and characterization of a membrane-associated cAMP-binding protein from developing Dictyostelium discoideum. | Plasma membranes of 6-h differentiated Dictyostelium discoideum cells contain a cAMP-binding protein with the properties ascribed to the chemotaxis receptor present on these cells. We have purified this cAMP-binding protein using DEAE-Sephadex chromatography, hydrophobic chromatography on decylagarose and preparative p... | ['Binding, Competitive', 'Cell Membrane', 'Cyclic AMP', 'Dictyostelium', 'Kinetics', 'Molecular Weight', 'Receptors, Cyclic AMP'] | 6,323,468 | [['E05.196.080', 'G02.111.084', 'G02.111.570.120.309'], ['A11.284.149'], ['D03.633.100.759.646.138.395', 'D13.695.462.200', 'D13.695.667.138.395', 'D13.695.827.068.395'], ['B01.046.550.200.300'], ['G01.374.661', 'G02.111.490'], ['G02.494'], ['D12.776.543.750.695.700.150', 'D12.776.543.750.720.700.150']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The influence of sex hormones on rat platelet sensitivity to adenosine-diphosphate. | The sensitivity of rat platelets to the aggregating agent adenosine-diphosphate (ADP) was studied. Platelets form male and female rats demonstrated comparable sensitivity. Neither ovariectomy nor castration altered platelet sensitivity to ADP. However platelets form mock-operated female, but not mock-operated male rats... | ['Adenosine Diphosphate', 'Animals', 'Blood Platelets', 'Castration', 'Estradiol', 'Female', 'Male', 'Rats', 'Rats, Inbred Strains', 'Testosterone'] | 7,302,887 | [['D03.633.100.759.646.138.124', 'D13.695.667.138.124', 'D13.695.827.068.124'], ['B01.050'], ['A11.118.188', 'A15.145.229.188'], ['E04.270.282', 'E04.950.165'], ['D04.210.500.365.415.248', 'D06.472.334.851.437.500'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760', 'B01.050.150.900.649.313.992.6... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Structural determinants of heparin-transforming growth factor-â1 interactions and their effects on signaling. | Transforming growth factor-â1 (TGF-â1, Uniprot: P01137) is a heparin-binding protein that has been implicated in a number of physiological processes, including the initiation of chondrogenesis by human mesenchymal stem cells (hMSCs). Here, we identify the molecular features in the protein and in heparin required for bi... | ['Amino Acid Sequence', 'Binding Sites', 'Cell Line', 'Cells, Cultured', 'Heparin', 'Humans', 'Mesenchymal Stem Cells', 'Molecular Sequence Data', 'Protein Binding', 'Signal Transduction', 'Smad2 Protein', 'Transforming Growth Factor beta1'] | 26,306,634 | [['G02.111.570.060', 'L01.453.245.667.060'], ['G02.111.570.120'], ['A11.251.210'], ['A11.251'], ['D09.698.373.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.329.830.500', 'A11.872.590.500'], ['L01.453.245.667'], ['G02.111.679', 'G03.808'], ['G02.111.820', 'G04.835'], ['D12.644.360.024.334.500.200', 'D12.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Weight-loss intervention using implementation intentions and mental imagery: a randomised control trial study protocol. | BACKGROUND: Overweight and obesity are major health problems worldwide. This protocol describes the HEALTHI (Healthy Eating and Active LifesTyle Health Intervention) Program, a 12-week randomised-controlled weight-loss intervention that adopts two theory-based intervention techniques, mental imagery and implementation ... | ['Adult', 'Behavior Therapy', 'Blood Glucose', 'Body Weight', 'Female', 'Humans', 'Imagery, Psychotherapy', 'Intention', 'Life Style', 'Male', 'Middle Aged', 'Motivation', 'Obesity', 'Quality of Life', 'Self Efficacy', 'Text Messaging', 'Weight Loss'] | 25,879,572 | [['M01.060.116'], ['F04.754.137'], ['D09.947.875.359.448.500'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.190.525.249', 'F04.754.462'], ['F01.658.650', 'F02.463.306'], ['F01.829.458'], ['M01... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Health Care [N]', 'I... | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 0 |
Digestibility of amino acid in full-fat canola seeds, canola meal, and canola expellers fed to broiler chickens and pigs. | Canola products including full-fat canola seeds (FFCS), canola meal (CM), and canola expellers (CE) have been used in diets for both broiler chickens and pigs. However, their ability to utilize the AA in canola products might be different from each other. Therefore, this study was conducted to compare the apparent ilea... | ['Amino Acids', 'Animal Feed', 'Animal Nutritional Physiological Phenomena', 'Animals', 'Brassica napus', 'Chickens', 'Diet', 'Digestion', 'Food Handling', 'Ileum', 'Male', 'Palmitic Acid', 'Seeds', 'Soybeans', 'Swine'] | 30,535,386 | [['D12.125'], ['G07.203.300.300.100', 'J02.500.300.100'], ['G07.203.650.161'], ['B01.050'], ['B01.650.940.800.575.912.250.157.200.249'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['G07.203.650.240'], ['G07.203.650.250', 'G10.261.190'], ['J01.576.423.200'], ['A03.556.124.684.249', 'A03.556.249.124'... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Ultrasound-assisted activation of zero-valent magnesium for nitrate denitrification: identification of reaction by-products and pathways. | Zero-valent magnesium (Mg(0)) was activated by ultrasound (US) in an aim to promote its potential use in water treatment without pH control. In this context, nitrate reduction was studied at batch conditions using various doses of magnesium powder and ultrasound power. While neither ultrasound nor zero-valent magnesium... | ['Denitrification', 'Magnesium', 'Nitrates', 'Oxidation-Reduction', 'Ultrasonics'] | 25,781,370 | [['G02.111.587.250', 'G02.607.560.250', 'G16.500.768.249'], ['D01.268.552.437', 'D01.268.557.500', 'D01.552.547.500'], ['D01.248.497.158.606', 'D01.625.525.550', 'D02.583'], ['G02.700', 'G03.295.531'], ['H01.671.031.849']] | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Differential D1 dephosphorylation in functional and photodamaged photosystem II centers. Dephosphorylation is a prerequisite for degradation of damaged D1. | Light dependence and kinetics of reversible phosphorylation of the D1 reaction center protein of Photosystem II was studied in pumpkin leaves. At growth light, maximal phosphorylation of D1 was observed after illumination of 1 h, with higher phosphorylation rates at stronger irradiances. 70-85% of D1 became phosphoryla... | ['Carbon Dioxide', 'Chlorophyll', 'Darkness', 'Kinetics', 'Light', 'Light-Harvesting Protein Complexes', 'Models, Biological', 'Phosphorylation', 'Photosynthesis', 'Photosynthetic Reaction Center Complex Proteins', 'Photosystem II Protein Complex', 'Plant Leaves', 'Sodium Fluoride', 'Vegetables'] | 8,663,006 | [['D01.200.200', 'D01.362.150', 'D01.650.550.200'], ['D03.383.129.578.840.374', 'D03.633.400.909.374', 'D04.345.783.374'], ['G01.590.540.233'], ['G01.374.661', 'G02.111.490'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['D05.500.562.488.490', 'D08.811.600.710.490', 'D12.776.543.930.50... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Cost-effectiveness of smoking cessation treatment initiated during psychiatric hospitalization: analysis from a randomized, controlled trial. | OBJECTIVE: We examined the cost-effectiveness of smoking cessation treatment for psychiatric inpatients.METHOD: Smokers, regardless of intention to quit, were recruited during psychiatric hospitalization and randomized to receive stage-based smoking cessation services or usual aftercare. Smoking cessation services, qua... | ['Adult', 'Cost-Benefit Analysis', 'Female', 'Health Care Costs', 'Health Services', 'Hospitalization', 'Humans', 'Inpatients', 'Male', 'Markov Chains', 'Mental Disorders', 'Smoking', 'Smoking Cessation'] | 26,528,651 | [['M01.060.116'], ['N03.219.151.125'], ['N03.219.151.400', 'N05.300.375'], ['N02.421'], ['E02.760.400', 'N02.421.585.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.643.470'], ['E05.318.740.600.500', 'E05.318.740.996.500', 'G17.830.500', 'N05.715.360.750.625.500', 'N05.715.360.750.770.500', 'N06.850.520.8... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Multiple Brain Metastases from Pancreatic Adenocarcinoma Manifesting with Simultaneous Intratumoral Hemorrhages. | BACKGROUND: Pancreatic adenocarcinoma rarely metastasizes to the brain, and clinical features of brain metastasis in such cases remain elusive. To the best of our knowledge, only 21 cases of brain metastasis from pancreatic adenocarcinoma have been previously reported in the English language literature.CASE DESCRIPTION... | ['Adenocarcinoma', 'Brain Neoplasms', 'Cerebral Hemorrhage', 'Fatal Outcome', 'Female', 'Humans', 'Middle Aged', 'Pancreatic Neoplasms'] | 30,579,022 | [['C04.557.470.200.025'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['C10.228.140.300.535.200', 'C14.907.253.573.200', 'C23.550.414.913.100'], ['E05.318.308.985.550.325', 'N01.224.935.698.201', 'N06.850.505.400.975.550.325', 'N06.850.520.308.985.550.325'], ['B01.050.150.900.649.313.988.400.112.400.... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Expression of potential molecular markers in prostate cancer: correlation with clinicopathological outcomes in patients undergoing radical prostatectomy. | The objective of this study was to evaluate the expression levels of multiple potential molecular markers in prostate cancer to clarify the significance of these markers as prognostic indicators in patients undergoing radical prostatectomy (RP). This study included a total of 193 patients with clinically organ-confined... | ['Aged', 'Biomarkers, Tumor', 'Humans', 'Immunohistochemistry', 'Male', 'Middle Aged', 'Neoplasm Recurrence, Local', 'Neoplasm Staging', 'Prognosis', 'Prostatectomy', 'Prostatic Neoplasms'] | 18,848,789 | [['M01.060.116.100'], ['D23.101.140'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512', 'H01.158.201.344.512', 'H01.158.201.486.512', 'H01.181.122.573.512', 'H01.181.122.605.512... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
The role of multiple hydrogen-bonding groups in specific alcohol binding sites in proteins: insights from structural studies of LUSH. | It is now generally accepted that many of the physiological effects of alcohol consumption are a direct result of binding to specific sites in neuronal proteins such as ion channels or other components of neuronal signaling cascades. Binding to these targets generally occurs in water-filled pockets and leads to alterat... | ['Amino Acid Substitution', 'Animals', 'Butanols', 'Crystallography, X-Ray', 'Drosophila melanogaster', 'Ethanol', 'Hydrogen Bonding', 'Models, Molecular', 'Mutagenesis, Site-Directed', 'Protein Binding', 'Receptors, Odorant'] | 18,234,222 | [['E05.393.420.601.035', 'G05.558.109'], ['B01.050'], ['D02.033.415.110', 'D10.289.110'], ['E05.196.309.742.225'], ['B01.050.500.131.617.720.500.500.750.310.250.500'], ['D02.033.375'], ['G02.282'], ['E05.599.595'], ['E05.393.420.601.575'], ['G02.111.679', 'G03.808'], ['D12.776.543.750.695.600']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Tetramer monitoring to assess risk factors for recurrent cytomegalovirus reactivation and reconstitution of antiviral immunity post allogeneic hematopoietic stem cell transplantation. | BACKGROUND: Reactivation of cytomegalovirus (CMV) is a major cause of morbidity after allogeneic hematopoietic stem cell transplantation (HSCT). In healthy individuals, virus-specific T cells (CMV-CTL) control the reactivation of latent CMV. The monitoring of virus-epitope-binding CD8(+) T cells using major histocompat... | ['Adult', 'CD8-Positive T-Lymphocytes', 'Cohort Studies', 'Cytomegalovirus', 'Cytomegalovirus Infections', 'Female', 'Hematopoietic Stem Cell Transplantation', 'Histocompatibility Antigens Class I', 'Humans', 'Immune Reconstitution Inflammatory Syndrome', 'Male', 'Middle Aged', 'Multiprotein Complexes', 'Peptides', 'Re... | 21,585,633 | [['M01.060.116'], ['A11.118.637.555.567.569.220', 'A15.145.229.637.555.567.569.220', 'A15.382.490.555.567.569.220'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['B04.280.382.150.150'], ['C01.925.256.466.245'], ['E02.095.147.500.500.500', 'E04.936.225.687.500'], ['D12.776.395.550.489'... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Significance of IA-2 antibody in Japanese type 1 diabetes: its association with GAD antibody. | To investigate the presence and level of serum antibodies to IA-2 (IA-2A) in Japanese patients with adult type 1 diabetes in order to clarify its association with glutamic acid decarboxylase (GAD) antibody. Serum samples were obtained from 101 Japanese patients with type 1 diabetes, including 37 patients with slowly pr... | ['Adult', 'Autoantibodies', 'Diabetes Mellitus, Type 1', 'Glutamate Decarboxylase', 'Humans', 'Japan', 'Prevalence'] | 15,620,435 | [['M01.060.116'], ['D12.776.124.486.485.114.323', 'D12.776.124.790.651.114.323', 'D12.776.377.715.548.114.323'], ['C18.452.394.750.124', 'C19.246.267', 'C20.111.327'], ['D08.811.520.224.125.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.474.463', 'Z01.639.595'], ['E05.318.308.985.525.750', 'N01.224.9... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Microtubule alterations occur early in experimental parkinsonism and the microtubule stabilizer epothilone D is neuroprotective. | The role of microtubule (MT) dysfunction in Parkinson's disease is emerging. It is still unknown whether it is a cause or a consequence of neurodegeneration. Our objective was to assess whether alterations of MT stability precede or follow axonal transport impairment and neurite degeneration in experimental parkinsonis... | ['1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine', 'Animals', 'Axonal Transport', 'Blotting, Western', 'Dopamine Agents', 'Dopaminergic Neurons', 'Epothilones', 'Immunoenzyme Techniques', 'MPTP Poisoning', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Microtubules', 'Nerve Degeneration', 'Neurons', 'Neuroprotective Agents', 'Pa... | 23,670,541 | [['D03.383.725.450'], ['B01.050'], ['G03.143.355.040', 'G04.392.040', 'G11.561.050'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['D27.505.519.625.150', 'D27.505.696.577.150'], ['A08.675.278', 'A11.671.270'], ['D02.540.576.500.984'], ['E05.478.566.350', 'E05.478... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
T cell tumorigenesis in Lmo2 transgenic mice is independent of V-D-J recombinase activity. | The LMO2 gene is involved in T-cell acute leukaemia (T-ALL) in children with chromosomal translocations t(11;14)(p13;q11) or (7;11)(q35;p13). Transgenic expression of Lmo2 in T cells results in clonal tumours with long latency indicating that mutations in other genes are required for the development of overt tumours. R... | ['Adaptor Proteins, Signal Transducing', 'Animals', 'DNA-Binding Proteins', 'Homeodomain Proteins', 'LIM Domain Proteins', 'Leukemia-Lymphoma, Adult T-Cell', 'Metalloproteins', 'Mice', 'Mice, Knockout', 'Mice, Transgenic', 'Mutation', 'Thymoma'] | 11,466,623 | [['D12.644.360.024', 'D12.776.157.057', 'D12.776.476.024'], ['B01.050'], ['D12.776.260'], ['D12.776.260.400'], ['D12.776.512'], ['C04.557.337.428.580.100', 'C15.604.515.560.575.100', 'C20.683.515.528.582.100'], ['D12.776.556'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.136.500.500', 'B01.050.150.900.64... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Kinetics of monensin complexation with sodium ions by 23NaNMR spectroscopy. | The kinetics of the sodium binding to the ionophore monensin (Mon) in methanol has been studied by 23NaNMR spectroscopy. Fast quadrupole relaxation of the bound sodium affected the relaxation rate of the free sodium through an exchange process between these two species. The exchange was found to be dominated by the rea... | ['Chemical Phenomena', 'Chemistry', 'Furans', 'Ionophores', 'Kinetics', 'Magnetic Resonance Spectroscopy', 'Monensin', 'Sodium', 'Sodium Radioisotopes', 'Temperature', 'Thermodynamics', 'Viscosity'] | 880,346 | [['G02'], ['H01.181'], ['D03.383.312'], ['D27.505.519.562.374', 'D27.720.395'], ['G01.374.661', 'G02.111.490'], ['E05.196.867.519'], ['D03.383.312.600'], ['D01.268.549.750', 'D01.268.557.650', 'D01.552.528.850', 'D01.552.547.725'], ['D01.268.549.750.500.800', 'D01.268.557.650.500.800', 'D01.496.749.795', 'D01.496.807.8... | ['Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Levodopa affects functional brain networks in Parkinsonian resting tremor. | Resting tremor in idiopathic Parkinson's disease (PD) is associated with an oscillatory network comprising cortical as well as subcortical brain areas. To shed light on the effect of levodopa on these network interactions, we investigated 10 patients with tremor-dominant PD and reanalyzed data in 11 healthy volunteers ... | ['Antiparkinson Agents', 'Brain', 'Brain Mapping', 'Cerebellum', 'Electromyography', 'Female', 'Humans', 'Levodopa', 'Male', 'Middle Aged', 'Motor Cortex', 'Nerve Net', 'Parietal Lobe', 'Parkinsonian Disorders', 'Somatosensory Cortex', 'Thalamus', 'Tremor'] | 18,823,037 | [['D27.505.954.427.090.050'], ['A08.186.211'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['A08.186.211.132.810.428.200'], ['E01.370.405.255', 'E01.370.530.255'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.092.311.200.480', 'D02.455.426.559.389.657.166.175.200.480', 'D12.125.... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A direct and simple method of coupling matrix-assisted laser desorption and ionization time-of-flight mass spectrometry (MALDI-TOF MS) to thin-layer chromatography (TLC) for the analysis of phospholipids from egg yolk. | Although the most important application of matrix-assisted laser desorption and ionization time-of-flight mass spectrometry (MALDI-TOF MS) is "proteomics," there is growing evidence that this soft ionization method is also useful for phospholipid (PL) analysis. Although all PLs are detectable by MALDI-TOF MS, some lipi... | ['Animals', 'Chickens', 'Chromatography, Thin Layer', 'Egg Yolk', 'Lasers', 'Phosphatidylcholines', 'Phospholipids', 'Reproducibility of Results', 'Sensitivity and Specificity', 'Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization'] | 17,673,987 | [['B01.050'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['E05.196.181.400.537'], ['A16.690.325', 'G07.203.300.470.800', 'J02.500.470.800'], ['E07.632.490', 'E07.710.520'], ['D10.570.755.375.760.400.800'], ['D10.570.755'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.7... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Activation of the particulate low Km phosphodiesterase of adipocytes by addition of cAMP-dependent protein kinase. | The purified catalytic subunit (C) of cAMP-dependent protein kinase produced a 2-fold activation of the low Km phosphodiesterase in crude microsomes (P-2 pellet) of rat adipocytes. This activation was C subunit concentration-dependent, ATP-dependent, blocked by a specific peptide inhibitor, and lost if the C subunit wa... | ['Adipose Tissue', 'Animals', 'Enzyme Activation', 'In Vitro Techniques', 'Kinetics', 'Macromolecular Substances', 'Male', 'Microsomes', 'Phosphoric Diester Hydrolases', 'Protein Kinases', 'Rats', 'Rats, Inbred Strains', 'Trypsin'] | 2,839,486 | [['A10.165.114'], ['B01.050'], ['G02.111.263', 'G03.328'], ['E05.481'], ['G01.374.661', 'G02.111.490'], ['D05'], ['A11.284.835.540'], ['D08.811.277.352.640'], ['D08.811.913.696.620.682'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760', 'B01.050.150.900.649.313.992.635.505.700.400'], ['D08.811.2... | ['Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Coronary calcium scanning independently detects coronary artery disease in asymptomatic firefighters: a prospective study. | BACKGROUND: Sudden cardiac death is the leading cause of death among firefighters in the United States. Fire departments commonly maintain physical examination protocols, often with exercise stress testing, to detect risk of coronary heart disease.OBJECTIVE: We sought to determine whether coronary calcium detected by e... | ['Adult', 'Age Distribution', 'Aged', 'Calcinosis', 'California', 'Comorbidity', 'Coronary Angiography', 'Coronary Artery Disease', 'Female', 'Firefighters', 'Humans', 'Male', 'Middle Aged', 'Prevalence', 'Risk Assessment', 'Tomography, X-Ray Computed', 'Young Adult'] | 23,394,820 | [['M01.060.116'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['M01.060.116.100'], ['C18.452.174.130'], ['Z01.107.567.875.580.200', 'Z01.107.567.875.760.200'], ['N05.715.350.225', 'N06.850.490.687'], ['E01.370.350.130.625', 'E01.370.350.700.060.200', 'E01.370.370.050.200', 'E01.370.370.380.200'], ['C14.280.6... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Diseases [C]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Gene cluster involved in the biosynthesis of griseobactin, a catechol-peptide siderophore of Streptomyces sp. ATCC 700974. | The main siderophores produced by streptomycetes are desferrioxamines. Here we show that Streptomyces sp. ATCC 700974 and several Streptomyces griseus strains, in addition, synthesize a hitherto unknown siderophore with a catechol-peptide structure, named griseobactin. The production is repressed by iron. We sequenced ... | ['Catechols', 'Gene Expression Regulation, Bacterial', 'Genetic Complementation Test', 'Genotype', 'Models, Genetic', 'Molecular Sequence Data', 'Multigene Family', 'Peptides', 'Sequence Analysis, DNA', 'Siderophores', 'Spectrometry, Mass, Electrospray Ionization', 'Streptomyces'] | 19,915,026 | [['D02.455.426.559.389.657.166'], ['G05.308.300'], ['E05.393.281.526'], ['G05.380'], ['E05.599.395.397'], ['L01.453.245.667'], ['G05.360.340.024.340.645'], ['D12.644'], ['E05.393.760.700'], ['D27.505.519.914.500.410.750', 'D27.720.832.500.410.750'], ['E05.196.566.600'], ['B03.300.390.400.810.768', 'B03.510.024.997.775'... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Rectal compliance, capacity, and rectoanal sensation in fecal incontinence. | OBJECTIVE: Assessments of the pathophysiology of fecal incontinence are skewed toward anal sphincter function; however, rectal compliance, rectoanal sensation and capacity may also be relevant. The aim of this study was to evaluate the usual and some novel diagnostic approaches in fecal incontinence.METHODS: In 22 unse... | ['Adult', 'Aged', 'Anal Canal', 'Compliance', 'Fecal Incontinence', 'Female', 'Humans', 'Male', 'Manometry', 'Middle Aged', 'Pain Threshold', 'Pilot Projects', 'Pressure', 'ROC Curve', 'Rectum', 'Sensation', 'Sensory Thresholds', 'Thermosensing', 'Ultrasonography'] | 11,467,648 | [['M01.060.116'], ['M01.060.116.100'], ['A03.556.124.526.070', 'A03.556.249.249.070'], ['G01.374.590.210'], ['C06.405.469.860.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.559'], ['M01.060.116.630'], ['F02.463.593.710.560', 'F02.830.816.444.700', 'G11.561.790.444.700'], ['E05.318.372.750', 'E05.337.737'... | ['Named Groups [M]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A novel technique to monitor thermal discharges using thermal infrared imaging. | Coastal temperature is an important indicator of water quality, particularly in regions where delicate ecosystems sensitive to water temperature are present. Remote sensing methods are highly reliable for assessing the thermal dispersion. The plume dispersion from the thermal outfall of the nuclear power plant at Kalpa... | ['Environmental Monitoring', 'India', 'Infrared Rays', 'Nuclear Power Plants', 'Oceans and Seas', 'Temperature', 'Water Quality'] | 23,839,171 | [['N06.850.460.350.080', 'N06.850.780.375'], ['Z01.252.245.393'], ['G01.358.500.505.650.552', 'G01.590.540.552', 'G01.750.250.650.552', 'G01.750.770.578.552', 'G16.500.275.063.725.525.400', 'G16.500.750.775.525.400', 'N06.230.300.100.725.525.400'], ['E07.710.600.500', 'J01.780.600', 'J03.540.680.600'], ['G01.311.625', ... | ['Health Care [N]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
Outcome and patient acceptance of outpatient laparoscopic cholecystectomy. | OBJECTIVE: The aim of this prospective study was to evaluate patients' experience and the outcome of outpatient laparoscopic cholecystectomy performed by a single upper gastrointestinal surgeon at a district hospital.METHODS: Between November 1999 and May 2003, 100 patients underwent outpatient laparoscopic cholecystec... | ['Adult', 'Ambulatory Surgical Procedures', 'Cholecystectomy, Laparoscopic', 'Female', 'Follow-Up Studies', 'Gallstones', 'Humans', 'Male', 'Morbidity', 'Patient Acceptance of Health Care', 'Patient Admission', 'Patient Readmission', 'Patient Satisfaction', 'Prospective Studies', 'Surveys and Questionnaires', 'Time Fac... | 15,347,113 | [['M01.060.116'], ['E04.030'], ['E04.210.120.172.140', 'E04.502.250.520.160'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['C06.130.409.633', 'C06.130.564.332.500', 'C23.300.175.525'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525', 'N01.224.935.5... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The Drosophila Grp/Chk1 DNA damage checkpoint controls entry into anaphase. | It is well established that DNA damage induces checkpoint-mediated interphase arrest in higher eukaryotes, but recent studies demonstrate that DNA damage delays entry into anaphase as well. Damaged DNA in syncytial and gastrulating Drosophila embryos delays the metaphase/anaphase transition . In human cultured cells, D... | ['Anaphase', 'Animals', 'Brain', 'Cell Cycle Proteins', 'Checkpoint Kinase 1', 'DNA Damage', 'DNA Mutational Analysis', 'DNA Restriction Enzymes', 'Drosophila', 'Drosophila Proteins', 'Larva', 'Metaphase', 'Neurons', 'Protein Kinases', 'Protein-Serine-Threonine Kinases', 'X-Rays'] | 15,723,794 | [['G04.144.220.220.687.222', 'G04.144.220.220.781.050', 'G05.113.220.687.250', 'G05.113.220.781.050'], ['B01.050'], ['A08.186.211'], ['D12.776.167'], ['D08.811.913.696.620.682.700.143'], ['G05.200'], ['E05.393.760.700.300'], ['D08.811.150.280', 'D08.811.277.352.335.350.300', 'D08.811.277.352.355.325.300'], ['B01.050.50... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Development and validation of an administrative case definition for inflammatory bowel diseases. | BACKGROUND: A population-based database of inflammatory bowel disease (IBD) patients is invaluable to explore and monitor the epidemiology and outcome of the disease. In this context, an accurate and validated population-based case definition for IBD becomes critical for researchers and health care providers.METHODS: I... | ['Colitis, Ulcerative', 'Humans', 'Inflammatory Bowel Diseases', 'Registries', 'Sensitivity and Specificity'] | 23,061,064 | [['C06.405.205.265.231', 'C06.405.205.731.249', 'C06.405.469.158.188.231', 'C06.405.469.432.249'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C06.405.205.731', 'C06.405.469.432'], ['E05.318.308.970', 'N04.452.859.819', 'N05.715.360.300.715.700', 'N06.850.520.308.970'], ['E05.318.370.800', 'E05.318.740.872', 'G1... | ['Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Making Sense of the 'Chemical Revolution'. Patients' Voices on the Introduction of Neuroleptics in the 1950s. | The so-called chemical revolution has produced a vast historiographical corpus. Yet the patient's voice remains surprisingly absent from these stories. Based on the archives of the Institut de Psychiatrie (Brussels), this paper traces the introduction of Largactil as recounted in patient letters, physician records and ... | ['Antipsychotic Agents', 'France', 'History, 20th Century', 'Hospitals, Psychiatric', 'Humans', 'Male', 'Mental Disorders', 'Professional-Patient Relations', 'Psychotropic Drugs', 'Treatment Refusal'] | 26,651,188 | [['D27.505.696.277.950.040', 'D27.505.954.427.210.950.040', 'D27.505.954.427.700.872.331'], ['Z01.542.286'], ['K01.400.504.968'], ['N02.278.421.556.508'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F03'], ['F01.829.401.650', 'N05.300.660'], ['D27.505.954.427.700'], ['F01.100.150.750.750', 'F01.145.488.887.750',... | ['Chemicals and Drugs [D]', 'Geographicals [Z]', 'Humanities [K]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
An analysis of career enquiries made to a school of radiography over a five-year period. | A follow-up enquiry form is described and results provided from a survey over a five-year period. The information gained has enabled a further and we hope more searching questionnaire to be designed. At the time of producing the pro-forma in 1969, career and salary prospects in radiography were not as good as at presen... | ['Allied Health Personnel', 'Career Choice', 'Decision Making', 'England', 'Radiography', 'Surveys and Questionnaires'] | 968,022 | [['M01.526.485.067', 'N02.360.067'], ['F02.463.785.373.346.400'], ['F02.463.785.373'], ['Z01.542.363.300'], ['E01.370.350.700'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980']] | ['Named Groups [M]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Metabolic effect of a LoBAG30 diet in men with type 2 diabetes. | We recently reported that in subjects with untreated type 2 diabetes a 5-wk diet of 30:30:40 carbohydrate/protein/fat ratio resulted in a significant decrease in 24-h integrated glucose, total %glycohemoglobin, and total cholesterol compared with a control diet of 55:15:30 carbohydrate/protein/fat given at the beginnin... | ['Blood Chemical Analysis', 'Cross-Over Studies', 'Diabetes Mellitus, Type 2', 'Diet, Diabetic', 'Dietary Carbohydrates', 'Dietary Proteins', 'Fatty Acids, Nonesterified', 'Human Growth Hormone', 'Humans', 'Insulin-Like Growth Factor I', 'Male', 'Uric Acid', 'Urinalysis'] | 16,720,631 | [['E01.370.225.124.100', 'E05.200.124.100'], ['E05.318.370.150', 'N05.715.360.325.150', 'N06.850.520.445.150'], ['C18.452.394.750.149', 'C19.246.300'], ['E02.642.249.240', 'G07.203.650.240.240'], ['D09.301', 'G07.203.300.362', 'J02.500.362'], ['D12.776.256', 'G07.203.300.428', 'J02.500.428'], ['D10.251.310'], ['D06.472... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Type C particle-positive and type C particle-negative rat cell lines: characterization of the coding capacity of endogenous sarcoma virus-specific RNA. | Various rat cell lines have been analyzed for expression of endogenous RNA homologous either to RT21C, a typical rat type C virus, or to Kirsten sarcoma virus. Cells have been found that express either (i) high levels of RNA homologous to RT21C rat type C virus and low levels of RNA homologous to Kirsten sarcoma virus ... | ['Base Sequence', 'Cell Line', 'Polyribosomes', 'RNA, Viral', 'RNA-Directed DNA Polymerase', 'Retroviridae', 'Transcription, Genetic', 'Viral Proteins'] | 62,849 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A11.251.210'], ['A11.284.430.214.190.875.811.740'], ['D13.444.735.828'], ['D08.811.913.696.445.308.300.750', 'D12.776.964.775.375.750', 'D12.776.964.900.750.500.750', 'D12.776.964.970.600.850.375.750'], ['B04.613.807', 'B04.820.650'], ['G02.111.873', 'G05.29... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Novel insights into Sabino1 and splashed white coat color patterns in horses. | Within the framework of genome-wide analyses using the novel Axiom® genotyping array, we investigated the distribution of two previously described coat color patterns, namely sabino1 (SBI), associated with the KIT gene (KI16+1037A), and splashed white, associated with the PAX3 gene (ECA6:g.11429753C>T; PAX3C70Y ), incl... | ['Adaptor Proteins, Signal Transducing', 'Alleles', 'Animals', 'Breeding', 'Genetic Association Studies', 'Hair Color', 'Heterozygote', 'Horses', 'PAX3 Transcription Factor', 'Phenotype', 'Pigmentation'] | 29,635,692 | [['D12.644.360.024', 'D12.776.157.057', 'D12.776.476.024'], ['G05.360.340.024.340.030'], ['B01.050'], ['E05.820.150', 'G05.090'], ['E05.393.385'], ['G13.500', 'G16.690.490'], ['G05.380.383'], ['B01.050.150.900.649.313.984.235.472'], ['D12.776.260.645.782', 'D12.776.930.700.782'], ['G05.695'], ['E01.370.600.620', 'G16.6... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A simple mathematical model of adaptation to high osmolarity in yeast. | We present a simple ordinary differential equation (ODE) model of the adaptive response to an osmotic shock in the yeast Saccharomyces cerevisiae. The model consists of two main components. First, a biophysical model describing how the cell volume and the turgor pressure are affected by varying extra-cellular osmolarit... | ['Acclimatization', 'Glycerol', 'Models, Biological', 'Osmolar Concentration', 'Osmotic Pressure', 'Reproducibility of Results', 'Saccharomyces cerevisiae', 'Water-Electrolyte Balance'] | 16,922,683 | [['G07.025.133', 'G16.012.500.133'], ['D02.033.800.875.500', 'D09.853.875.500'], ['E05.599.395'], ['G02.640'], ['G01.374.715.578', 'G02.640.249', 'G02.723.661'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['B01.300.107.795.785.800', 'B01.300.930.705.655'], ['G02.111.635.500', 'G03... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Coronary stent implantation is superior to balloon angioplasty for chronic coronary occlusions: six-year clinical follow-up of the GISSOC trial. | OBJECTIVES: We investigated whether the benefits of stent implantation over balloon percutaneous transluminal coronary angioplasty (PTCA) for treatment of chronic total coronary occlusions (CTO) are maintained in the long term.BACKGROUND: Several randomized trials have shown that in CTO, stent implantation confers clin... | ['Adult', 'Aged', 'Angioplasty, Balloon, Coronary', 'Blood Vessel Prosthesis Implantation', 'Chronic Disease', 'Coronary Angiography', 'Coronary Stenosis', 'Disease-Free Survival', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Middle Aged', 'Stents', 'Time Factors'] | 12,742,287 | [['M01.060.116'], ['M01.060.116.100'], ['E02.148.050.060.100', 'E04.100.376.719.100', 'E04.100.814.529.124.060.100', 'E04.100.814.529.968.050', 'E04.502.382.124.060.100', 'E04.502.382.968.050', 'E04.928.220.520.100', 'E05.157.016.060.100'], ['E04.100.814.868.500', 'E04.650.200'], ['C23.550.291.500'], ['E01.370.350.130.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Photopenic defects in marrow-containing skeleton on indium-111 leucocyte scintigraphy: prevalence at sites suspected of osteomyelitis and as an incidental finding. | The skeletal distribution of red marrow-containing sites with a decreased uptake of indium-111-labelled leucocytes was examined as part of a retrospective review of 128 consecutive scans in 113 patients. The prevalence of photopenic defects was determined for sites of suspected osteomyelitis and for other skeletal loca... | ['Bone Marrow', 'Bone and Bones', 'Female', 'Humans', 'Indium Radioisotopes', 'Leukocytes', 'Male', 'Middle Aged', 'Osteomyelitis', 'Radionuclide Imaging', 'Retrospective Studies'] | 1,451,701 | [['A15.382.216'], ['A02.835.232', 'A10.165.265'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.496.749.460'], ['A11.118.637', 'A15.145.229.637', 'A15.382.490'], ['M01.060.116.630'], ['C01.160.495', 'C05.116.165.495'], ['E01.370.350.710', 'E01.370.384.730'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750... | ['Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A putative serine protease, SpSsp1, from Saprolegnia parasitica is recognised by sera of rainbow trout, Oncorhynchus mykiss. | Saprolegniosis, the disease caused by Saprolegnia sp., results in considerable economic losses in aquaculture. Current control methods are inadequate, as they are either largely ineffective or present environmental and fish health concerns. Vaccination of fish presents an attractive alternative to these control methods... | ['Animals', 'Antibodies', 'Antigens', 'Aquaculture', 'Chromatography, Liquid', 'Electrophoresis, Gel, Two-Dimensional', 'Electrophoresis, Polyacrylamide Gel', 'Oncorhynchus mykiss', 'Saprolegnia', 'Serine Proteases', 'Tandem Mass Spectrometry', 'United Kingdom'] | 25,088,077 | [['B01.050'], ['D12.776.124.486.485.114', 'D12.776.124.790.651.114', 'D12.776.377.715.548.114'], ['D23.050'], ['J01.040.168'], ['E05.196.181.400'], ['E05.196.401.250', 'E05.301.300.230'], ['E05.196.401.402', 'E05.301.300.319'], ['B01.050.150.900.493.817.750.825.580.600'], ['B01.750.580.825'], ['D08.811.277.656.959'], [... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 |
High-throughput gene and SNP discovery in Eucalyptus grandis, an uncharacterized genome. | BACKGROUND: Benefits from high-throughput sequencing using 454 pyrosequencing technology may be most apparent for species with high societal or economic value but few genomic resources. Rapid means of gene sequence and SNP discovery using this novel sequencing technology provide a set of baseline tools for genome-level... | ['Alleles', 'DNA, Complementary', 'Eucalyptus', 'Expressed Sequence Tags', 'Gene Library', 'Genes, Plant', 'Genetic Variation', 'Haplotypes', 'Polymorphism, Single Nucleotide', 'Reproducibility of Results', 'Sequence Analysis, DNA', 'Software', 'Transcription, Genetic'] | 18,590,545 | [['G05.360.340.024.340.030'], ['D13.444.308.497.220', 'D13.444.600.223.500', 'D27.720.470.530.600.223.260'], ['B01.650.940.800.575.912.250.773.366'], ['G05.360.340.024.340.137.275'], ['G05.360.325'], ['G05.360.340.024.340.393', 'G05.360.340.365.500'], ['G05.365'], ['G05.380.360'], ['G05.365.795.598'], ['E05.318.370.725... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Information Science [L]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Environmental survey of salmonella and comparison of genotypic character with human isolates in Western Japan. | To estimate the prevalence and distribution of salmonellae, especially Salmonella enterica subsp. enterica serovar Enteritidis (S. Enteritidis), in Western Japan, an investigation was conducted of the chicken industry and environmental sources between 1995 and 1998. Salmonellae were isolated from 34 of 90 samples (37.8... | ['Animals', 'Bacteriophage Typing', 'Chickens', 'Disease Outbreaks', 'Eggs', 'Electrophoresis, Gel, Pulsed-Field', 'Environmental Microbiology', 'Food Microbiology', 'Genotype', 'Humans', 'Japan', 'Meat', 'Prevalence', 'Salmonella Food Poisoning', 'Salmonella enteritidis', 'Water Microbiology'] | 11,349,965 | [['B01.050'], ['E01.370.225.875.150.125.150', 'E05.200.875.150.125.150'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['N06.850.290'], ['G07.203.300.470', 'J02.500.470'], ['E05.196.401.220', 'E05.301.300.220'], ['H01.158.273.540.274', 'N06.850.425'], ['H01.158.273.540.274.332', 'J01.576.423.850.730.... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Disciplines and Occupations [H]', 'Geographicals [Z]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 |
Different respiratory behaviors disclosed by induced bronchoconstriction in mild asthma patients. | Respiratory responses to bronchoconstriction in asthma have been partially assessed and their significance is unclear. In 44 mild asthma patients we investigated respiratory responses during increasing levels of methacholine-induced bronchoconstriction. Inspiratory muscle activity, tidal volume, inspiratory and expirat... | ['Adult', 'Asthma', 'Bronchial Provocation Tests', 'Bronchoconstriction', 'Bronchoconstrictor Agents', 'Dyspnea', 'Electromyography', 'Female', 'Humans', 'Male', 'Methacholine Chloride', 'Plethysmography', 'Pulmonary Ventilation', 'Tidal Volume', 'Time Factors', 'Visual Analog Scale', 'Young Adult'] | 23,999,000 | [['M01.060.116'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['E01.370.386.700.125'], ['G09.772.705.700.080'], ['D27.505.696.663.050.100', 'D27.505.954.796.170'], ['C08.618.326', 'C23.888.852.371'], ['E01.370.405.255', 'E01.370.530.255'], ['B01.050.150.900.649.313.988.400.112.400.400'], [... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Bioequivalence study of two letrozole tablet formulations. Single dose, randomized, open-label, two-way crossover bioequivalence study of letrozole 2.5 mg tablets in healthy volunteers under fasting conditions. | The study was conducted in order to compare the bioavailability of two tablet formulations containing letrozole 2.5 mg (CAS 112809-51-5). Twenty healthy subjects were enrolled in a single-centre, bioequivalence, randomised, single-dose, open-label, two-way crossover study, performed under fasting conditions with a mini... | ['Adult', 'Aged', 'Antineoplastic Agents', 'Area Under Curve', 'Aryl Hydrocarbon Hydroxylases', 'Chemistry, Pharmaceutical', 'Cross-Over Studies', 'Cytochrome P-450 CYP2A6', 'Double-Blind Method', 'Fasting', 'Female', 'Humans', 'Letrozole', 'Linear Models', 'Middle Aged', 'Nitriles', 'Tablets', 'Triazoles'] | 18,807,583 | [['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.248'], ['E05.318.740.200', 'G03.787.101', 'G07.690.725.064', 'N06.850.520.830.200'], ['D08.244.453.005', 'D08.811.682.690.708.170.010', 'D12.776.422.220.453.010'], ['H01.158.703.007', 'H01.181.466'], ['E05.318.370.150', 'N05.715.360.325.150', 'N06.850.520.445.150'], ... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Psychiatry and Psychology [F]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Overexpression and mutagenesis of the catalytic domain of dihydrolipoamide acetyltransferase from Saccharomyces cerevisiae. | The inner core domain (residues approximately 221-454) of the dihydrolipoamide acetyltransferase component (E2P) of the pyruvate dehydrogenase complex from Saccharomyces cerevisiae has been overexpressed in Escherichia coli strain JM105 via the expression vector pKK233-2. The truncated E2p was purified to apparent homo... | ['Acetyltransferases', 'Base Sequence', 'Binding Sites', 'Catalysis', 'Consensus Sequence', 'Dihydrolipoyllysine-Residue Acetyltransferase', 'Fungal Proteins', 'Genetic Vectors', 'Molecular Sequence Data', 'Mutagenesis, Site-Directed', 'Oligodeoxyribonucleotides', 'Protein Conformation', 'Protein Engineering', 'Pyruvat... | 2,271,545 | [['D08.811.913.050.134'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G02.111.570.120'], ['G02.130'], ['G02.111.570.580.175'], ['D05.500.562.625.750', 'D08.811.600.741.625', 'D08.811.913.050.134.310'], ['D12.776.354'], ['G05.360.337'], ['L01.453.245.667'], ['E05.393.420.601.575'], ['D13.695.578.424.450... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Neuroprotective exendin-4 enhances hypothermia therapy in a model of hypoxic-ischaemic encephalopathy. | Hypoxic-ischaemic encephalopathy remains a global health burden. Despite medical advances and treatment with therapeutic hypothermia, over 50% of cooled infants are not protected and still develop lifelong neurodisabilities, including cerebral palsy. Furthermore, hypothermia is not used in preterm cases or low resource... | ['Animals', 'Animals, Newborn', 'Brain', 'Disease Models, Animal', 'Exenatide', 'Humans', 'Hypothermia, Induced', 'Hypoxia-Ischemia, Brain', 'Mice', 'Neuroprotective Agents'] | 30,165,597 | [['B01.050'], ['B01.050.050.282'], ['A08.186.211'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['D12.644.187', 'D20.888.300', 'D23.946.833.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.258.750'], ['C10.228.140.300.150.716', 'C10.228.140.624.500', 'C14.907.253.092.716', 'C23.888.852.079.797.500'], ['... | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Implantation of balloon-expandable intravascular grafts by catheterization in pulmonary arteries and systemic veins. | The purpose of this investigation was to evaluate the efficacy and safety of implanting expandable intravascular stents in pulmonary arteries and systemic veins. Twenty-seven balloon-expandable grafts were placed in 13 mongrel dogs under anesthesia. A long sheath was introduced over a wire and catheter or dilator into ... | ['Animals', 'Blood Vessel Prosthesis', 'Catheterization', 'Constriction, Pathologic', 'Dogs', 'Female', 'Male', 'Prostheses and Implants', 'Pulmonary Artery', 'Stainless Steel', 'Vascular Diseases'] | 3,335,067 | [['B01.050'], ['E07.695.110'], ['E02.148', 'E05.157'], ['C23.300.287'], ['B01.050.150.900.649.313.750.250.216.200'], ['E07.695'], ['A07.015.114.715'], ['D01.490.800.900', 'D01.552.033.847.681', 'D25.058.807.681', 'J01.637.051.058.807.681'], ['C14.907']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Use of glycopyrrolate in the treatment of Meniere's disease. | OBJECTIVES/HYPOTHESIS: The objective of this study was to determine whether glycopyrrolate is useful as a vestibular suppressant in patients with Meniere's disease. The tested hypotheses were that glycopyrrolate would decrease the perception of dizziness measured by the Dizziness Handicap Inventory in patients with Men... | ['Adult', 'Aged', 'Audiometry', 'Female', 'Glycopyrrolate', 'Humans', 'Male', 'Meniere Disease', 'Middle Aged', 'Parasympatholytics', 'Prospective Studies', 'Treatment Outcome', 'Vertigo'] | 9,778,280 | [['M01.060.116'], ['M01.060.116.100'], ['E01.370.382.375.060'], ['D02.092.877.425', 'D02.675.276.425', 'D03.383.773.342'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C09.218.568.217.500'], ['M01.060.116.630'], ['D27.505.696.663.050.650'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.4... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A quick rhizobacterial selection tests for the remediation of copper contaminated soils. | AIMS: The main objective of the study is to develop and improve quick bacterial tests to select the best candidates for the bioaugmentation of metal-contaminated soil, coupled with phytoextraction.METHODS AND RESULTS: Bacteria isolates (181) were selected from a collection originated from a Cu-contaminated sediment, on... | ['Bacteria', 'Biodegradation, Environmental', 'Copper', 'Hydroxides', 'Molecular Sequence Data', 'Siderophores', 'Soil Microbiology', 'Soil Pollutants'] | 26,042,640 | [['B03'], ['N06.230.080.600.500', 'N06.850.460.375.500'], ['D01.268.556.195', 'D01.268.956.170', 'D01.552.544.195'], ['D01.045.250', 'D01.248.497.158.459'], ['L01.453.245.667'], ['D27.505.519.914.500.410.750', 'D27.720.832.500.410.750'], ['H01.158.273.540.274.555', 'N06.850.425.300'], ['D27.888.284.756']] | ['Organisms [B]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Information Science [L]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Femtosecond laser-assisted hyperopic laser in situ keratomileusis with tissue-saving ablation: analysis of 800 eyes. | PURPOSE: To evaluate the results and complications of hyperopic laser in situ keratomileusis (LASIK) with a low-energy femtosecond laser and non-custom tissue-saving ablation profile.SETTING: Private practice, Siena, Italy.DESIGN: Case series.METHODS: Hyperopic eyes with a spherical equivalent (SE) between +1.0 and +6.... | ['Adult', 'Cornea', 'Corneal Pachymetry', 'Corneal Topography', 'Female', 'Humans', 'Hyperopia', 'Intraocular Pressure', 'Intraoperative Complications', 'Keratomileusis, Laser In Situ', 'Lasers, Excimer', 'Male', 'Postoperative Complications', 'Prospective Studies', 'Reoperation', 'Surgical Flaps', 'Tonometry, Ocular',... | 24,874,770 | [['M01.060.116'], ['A09.371.060.217'], ['E01.370.380.112'], ['E01.370.380.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C11.744.479'], ['G14.440'], ['C23.550.505'], ['E02.594.480.750', 'E04.014.520.480.750', 'E04.378.500.750', 'E04.540.825.437.374'], ['E07.632.490.244', 'E07.710.520.244'], ['C23.550.767'], ... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Blast: injury patterns and their recording. | Exposure to explosive blast results in a variety of injuries dependent on the degree of blast loading, the relative contribution of secondary fragments and the interaction of a casualty with the surroundings. The internal and more covert injuries peculiar to blast are easily overlooked in the haste to treat the obvious... | ['Blast Injuries', 'Humans', 'Photography', 'Radiography'] | 1,460,242 | [['C26.120.126'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.600', 'E05.712'], ['E01.370.350.700']] | ['Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The clinical and cost effectiveness of cognitive behavioural therapy plus treatment as usual for the treatment of depression in advanced cancer (CanTalk): study protocol for a randomised controlled trial. | BACKGROUND: The prevalence of depressive disorder in adults with advanced cancer is around 20 %. Although cognitive behavioural therapy (CBT) is recommended for depression and may be beneficial in depressed people with cancer, its use for depression in those with advanced disease for whom cure is not likely has not bee... | ['Antidepressive Agents', 'Clinical Protocols', 'Cognitive Behavioral Therapy', 'Combined Modality Therapy', 'Cost-Benefit Analysis', 'Depressive Disorder, Major', 'Drug Costs', 'England', 'Humans', 'Neoplasms', 'Psychiatric Status Rating Scales', 'Quality of Life', 'Quality-Adjusted Life Years', 'Research Design', 'Si... | 26,926,910 | [['D27.505.954.427.700.122'], ['E02.183', 'N05.715.360.330.125'], ['F04.754.137.350'], ['E02.186'], ['N03.219.151.125'], ['F03.600.300.375'], ['N03.219.151.400.350', 'N05.300.375.300'], ['Z01.542.363.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04'], ['F04.711.513.653'], ['I01.800', 'K01.752.400.750', 'N0... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]', 'Organisms [B]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Disciplines and Occupations [H]... | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 |
Spontaneous recovery rates for unilateral sixth nerve palsies. | Two hundred and thirteen patients with unilateral isolated sixth nerve palsies were assessed to determine what proportion of them underwent spontaneous recovery and over what period of time this recovery occurred. All were primary ophthalmic referrals from which trauma was excluded. In all, 78.4% of patients experience... | ['Abducens Nerve', 'Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Child', 'Child, Preschool', 'Cranial Nerve Diseases', 'Diplopia', 'Female', 'Humans', 'Male', 'Middle Aged', 'Ophthalmoplegia', 'Remission, Spontaneous', 'Time Factors'] | 7,498,570 | [['A08.800.800.120.030'], ['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['M01.060.406'], ['M01.060.406.448'], ['C10.292'], ['C10.597.751.941.339', 'C11.966.339', 'C23.888.592.763.941.339'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C10.292.562.750', 'C10.5... | ['Anatomy [A]', 'Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Excision of Expanded GAA Repeats Alleviates the Molecular Phenotype of Friedreich's Ataxia. | Friedreich's ataxia (FRDA) is an autosomal recessive neurological disease caused by expansions of guanine-adenine-adenine (GAA) repeats in intron 1 of the frataxin (FXN) gene. The expansion results in significantly decreased frataxin expression. We report that human FRDA cells can be corrected by zinc finger nuclease-m... | ['Aconitate Hydratase', 'Adenine', 'Alleles', 'Cell Differentiation', 'Endodeoxyribonucleases', 'Fibroblasts', 'Friedreich Ataxia', 'Genetic Therapy', 'Guanine', 'Heterozygote', 'Humans', 'Induced Pluripotent Stem Cells', 'Introns', 'K562 Cells', 'Neurons', 'Phenotype', 'RNA, Messenger', 'Trinucleotide Repeat Expansion... | 25,758,173 | [['D08.811.520.241.300.050'], ['D03.633.100.759.138'], ['G05.360.340.024.340.030'], ['G04.152'], ['D08.811.277.352.335.350', 'D08.811.277.352.355.325'], ['A11.329.228'], ['C10.228.140.252.700.150', 'C10.228.854.787.200', 'C10.574.500.825.200', 'C16.320.400.780.200', 'C18.452.660.300'], ['E02.095.301', 'E05.393.420.301'... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
RAE-1, a novel PHR binding protein, is required for axon termination and synapse formation in Caenorhabditis elegans. | Previous studies in Caenorhabditis elegans showed that RPM-1 (Regulator of Presynaptic Morphology-1) regulates axon termination and synapse formation. To understand the mechanism of how rpm-1 functions, we have used mass spectrometry to identify RPM-1 binding proteins, and have identified RAE-1 (RNA Export protein-1) a... | ['Adaptor Proteins, Signal Transducing', 'Amino Acid Motifs', 'Amino Acid Sequence', 'Animals', 'Animals, Genetically Modified', 'Axons', 'Caenorhabditis elegans', 'Caenorhabditis elegans Proteins', 'F-Box Proteins', 'Gene Expression Regulation', 'Guanine Nucleotide Exchange Factors', 'Humans', 'Immunoprecipitation', '... | 22,357,847 | [['D12.644.360.024', 'D12.776.157.057', 'D12.776.476.024'], ['G02.111.570.820.709.275.500', 'G02.111.570.820.709.600.500'], ['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['B01.050.050.136', 'B05.620.136'], ['A08.675.542.145', 'A11.284.180.075', 'A11.671.137', 'A11.671.501.145'], ['B01.050.500.500.294.400.875... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Improved identification of endothelial erosion by simultaneous detection of endothelial cells (CD31/CD34) and platelets (CD42b). | Loss of endothelial cells (ECs) with ensuing exposure of thrombogenic subendothelial surface is a common cause of thromboembolic complications in atherosclerotic arteries. Thus, endothelial denudation has emerged as a major contributor to the pathogenesis of atherosclerosis and its complications. Despite ongoing effort... | ['Adult', 'Antigens, CD34', 'Blood Platelets', 'Blotting, Western', 'Coronary Vessels', 'Endothelial Cells', 'Humans', 'Middle Aged', 'Platelet Aggregation', 'Platelet Endothelial Cell Adhesion Molecule-1', 'Platelet Glycoprotein GPIb-IX Complex'] | 17,497,364 | [['M01.060.116'], ['D23.050.301.264.035.134', 'D23.101.100.110.134'], ['A11.118.188', 'A15.145.229.188'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['A07.015.114.269', 'A07.015.908.194'], ['A11.436.275'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.0... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
miR-183 as a molecular and protective biomarker for cancer in schizophrenic subjects. | Previous studies have suggested that schizophrenia is associ-ated with a reduced risk of cancer. Genes that are involved in cell cycle regulation seem to have additional functions in post-mitotic neurons involved in neuronal migration and synaptic plasticity. MicroRNAs (miRNAs) play ... | ['Adult', 'Aged', 'Apoptosis', 'Biomarkers, Tumor', 'Down-Regulation', 'Female', 'Gene Expression Profiling', 'Gene Expression Regulation, Neoplastic', 'Genes, Tumor Suppressor', 'Humans', 'Male', 'MicroRNAs', 'Middle Aged', 'Neoplasms', 'Schizophrenia'] | 23,007,659 | [['M01.060.116'], ['M01.060.116.100'], ['G04.146.954.035'], ['D23.101.140'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['E05.393.332'], ['G05.308.370'], ['G05.360.340.024.340.375.249', 'G05.360.340.024.340.415.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D13.150.650.319', 'D13.444.735.150.319', 'D... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Etomidate and mortality in cirrhotic patients with septic shock. | BACKGROUND: Clinical effects and outcomes of a single dose etomidate prior to intubation in the intensive care setting is controversial. The aim of this study is to evaluate the association of a single dose effect of etomidate prior to intubation on the mortality of septic cirrhotic patients and the impact of the subse... | ['Cohort Studies', 'Double-Blind Method', 'Etomidate', 'Female', 'Fibrosis', 'Hospital Mortality', 'Humans', 'Hydrocortisone', 'Intensive Care Units', 'Intubation', 'Male', 'Middle Aged', 'Shock, Septic', 'Treatment Outcome', 'Vasoconstrictor Agents'] | 22,208,901 | [['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['D03.383.129.308.265'], ['C23.550.355'], ['E05.318.308.985.550.400', 'N01.224.935.698.400', 'N06.850.505.400.975.550.400', 'N06.850.520.308.985.550.400']... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Coupled folding and binding of the disordered protein PUMA does not require particular residual structure. | Many cellular proteins are 'disordered' in isolation. A subset of these intrinsically disordered proteins (IDPs) can, upon binding another molecule, fold to a well-defined three-dimensional structure. In the structurally heterogeneous, unbound ensemble of these IDPs, conformations are likely to exist that, in part, res... | ['Apoptosis Regulatory Proteins', 'Binding Sites', 'Humans', 'Models, Molecular', 'Myeloid Cell Leukemia Sequence 1 Protein', 'Protein Conformation', 'Protein Folding', 'Proto-Oncogene Proteins'] | 24,654,952 | [['D12.644.360.075', 'D12.776.476.075'], ['G02.111.570.120'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.595'], ['D12.644.360.075.718.984', 'D12.776.476.075.718.968', 'D12.776.624.664.700.169.500'], ['G02.111.570.820.709'], ['G01.154.651', 'G02.111.688'], ['D12.776.624.664.700']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Prophylactic systemic P2X7 receptor blockade prevents experimental colitis. | BACKGROUND: The P2X7 receptor (P2X7-R) is a non-selective adenosine triphosphate-gated cation channel present in epithelial and immune cells, and involved in inflammatory response. Extracellular nucleotides released in conditions of cell stress or inflammation may function as a danger signal alerting the immune system ... | ['Animals', 'Anti-Inflammatory Agents', 'Apoptosis', 'Colitis', 'Collagen', 'Colon', 'Extracellular Signal-Regulated MAP Kinases', 'Gene Expression', 'Goblet Cells', 'Injections, Intraperitoneal', 'Macrophages', 'Male', 'NF-kappa B', 'Peroxidase', 'Purinergic P2X Receptor Antagonists', 'Rats', 'Rats, Wistar', 'Receptor... | 24,184,714 | [['B01.050'], ['D27.505.954.158'], ['G04.146.954.035'], ['C06.405.205.265', 'C06.405.469.158.188'], ['D05.750.078.280', 'D12.776.860.300.250'], ['A03.556.124.526.356', 'A03.556.249.249.356'], ['D08.811.913.696.620.682.700.567.249', 'D12.644.360.450.169', 'D12.776.476.450.169'], ['G05.297'], ['A03.556.124.369.320', 'A04... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cloning, expression, purification and preliminary X-ray crystallographic studies of Escherichia coli Hsp100 ClpB N-terminal domain. | Escherichia coli Hsp100 ClpB plays critical roles in multi-chaperone systems in cell physiology. After the ATPase activity is stimulated by protein or peptide binding, ClpB disaggregates denatured polypeptides by employing ATP hydrolysis and allows other molecular chaperones such as Hsp70 DnaK and Hsp40 DnaJ to more ef... | ['Crystallization', 'Crystallography, X-Ray', 'Endopeptidase Clp', 'Escherichia coli', 'Heat-Shock Proteins', 'Protein Conformation', 'Protein Structure, Tertiary', 'Protozoan Proteins'] | 11,717,522 | [['E05.196.300', 'G02.171'], ['E05.196.309.742.225'], ['D08.811.277.040.013.500.032.099.500', 'D08.811.277.040.025.024.032.099.500', 'D08.811.277.656.149.099.500', 'D08.811.277.656.300.065.500', 'D12.776.157.025.750.032.099.500', 'D12.776.575.374', 'D12.776.765.199.249'], ['B03.440.450.425.325.300', 'B03.660.250.150.18... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Revisiting the novelty effect: when familiarity, not novelty, enhances memory. | Reports of superior memory for novel relative to familiar material have figured prominently in recent theories of memory. However, such novelty effects are incongruous with long-standing observations that familiar items are remembered better. In 2 experiments, we explored whether this discrepancy was explained by diffe... | ['Female', 'Humans', 'Male', 'Mental Recall', 'Photic Stimulation', 'Recognition, Psychology', 'Young Adult'] | 20,804,299 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.425.540.641'], ['E05.723.729'], ['F02.463.425.540.706'], ['M01.060.116.815']] | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Interaction of recA protein with left-handed Z-DNA. | The ability of recA protein to interact with a Z-DNA polymer, Br-poly(dG-dC), or M13 bacteriophage single-stranded DNA was investigated. RecA protein binds more avidly to Z-DNA than to single-stranded DNA in the absence of a nucleotide cofactor. This binding pattern changes in the presence of adenosine 5'-(gamma-thio)t... | ['Adenosine Triphosphate', 'Bacteriophages', 'Binding, Competitive', 'Cross-Linking Reagents', 'DNA', 'DNA, Single-Stranded', 'DNA, Viral', 'Escherichia coli', 'Nucleic Acid Conformation', 'Plasmids', 'Polydeoxyribonucleotides', 'Rec A Recombinases'] | 2,039,448 | [['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['B04.123'], ['E05.196.080', 'G02.111.084', 'G02.111.570.120.309'], ['D27.720.470.410.210'], ['D13.444.308'], ['D13.444.308.497', 'G02.111.570.820.486.437', 'G05.360.580.437'], ['D13.444.308.568'], ['B03.440.450.425.325.300', 'B03.660.250.1... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Common cuckoo females may escape male sexual harassment by color polymorphism. | Sexual conflict over mating rate is widely regarded as a selective force on the evolution of female-limited color polymorphism in invertebrates, such as damselflies and butterflies. However, evidence confirming its use in higher vertebrates remains limited. The common cuckoo, Cuculus canorus, is an avian brood parasite... | ['Animals', 'Biological Evolution', 'Birds', 'Copulation', 'Female', 'Male', 'Mating Preference, Animal', 'Models, Biological', 'Pigmentation', 'Polymorphism, Genetic', 'Republic of Korea', 'Sexual Behavior, Animal'] | 31,101,873 | [['B01.050'], ['G05.045', 'G16.075'], ['B01.050.150.900.248'], ['F01.145.113.252.748.200'], ['F01.145.113.252.748.300'], ['E05.599.395'], ['E01.370.600.620', 'G16.690'], ['G05.365.795'], ['Z01.252.474.557.750'], ['F01.145.113.252.748']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Mechanism of infiltration and activation of glomerular monocytes/macrophages in IgA nephropathy. | Glomerular deposits of fibrin-related antigens (FRA), C3c, membrane attack complex (MAC) were examined by the immunoperoxidase method on 176 renal biopsy specimens from 120 cases with IgA nephropathy including 56 cases with sequential biopsies. On 47 sets of repeated renal biopsy specimens, the glomerular infiltration ... | ['Adult', 'Antigens', 'Biopsy', 'Complement C3c', 'Complement Membrane Attack Complex', 'Female', 'Fibrin Fibrinogen Degradation Products', 'Glomerulonephritis, IGA', 'Humans', 'Immunoenzyme Techniques', 'Kidney Glomerulus', 'Macrophage Activation', 'Macrophages', 'Male', 'Monocytes'] | 9,096,444 | [['M01.060.116'], ['D23.050'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['D12.776.124.486.274.250.260.500'], ['D12.776.124.486.274.930'], ['D12.776.124.270.300', 'D12.776.811.300.290'], ['C12.777.419.570.363.608', 'C13... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
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