Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Cancer-associated fibroblasts enhance pancreatic cancer cell invasion by remodeling the metabolic conversion mechanism. | We investigated the mechanism of cancer-associated fibroblasts (CAFs) in promoting the invasion and metastasis of pancreatic cancer cells in a non-vascular manner. We verified the original generation of isolated cultured CAFs and normal fibroblasts (NFs) based on the expression of á-SMA and vimentin, and we examined th... | ['Actins', 'Cancer-Associated Fibroblasts', 'Cell Adhesion', 'Cell Cycle Proteins', 'Cell Line, Tumor', 'Cell Movement', 'Cell Proliferation', 'Fumarate Hydratase', 'Gene Expression Regulation, Neoplastic', 'Humans', 'Neoplasm Invasiveness', 'Oncogene Proteins', 'Oxidative Phosphorylation', 'Pancreatic Neoplasms', 'Suc... | 28,260,082 | [['D05.750.078.730.250', 'D12.776.210.500.100', 'D12.776.220.525.255'], ['A11.329.228.105'], ['G04.022'], ['D12.776.167'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.198', 'G07.568.500.180'], ['G04.161.750', 'G07.345.249.410.750'], ['D08.811.520.241.300.300'], ['G05.308.370'], ['B01.050.150.900.649.313.988.400.112.4... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[A case of idiopathic hypertrophic cranial pachymeningitis presenting as chronic subdural hematoma]. | A 26-year-old male presented with a 6-day history of paroxysmal headache which was worsen with nausea and vomiting for 1 day. Head CT on admission revealed left chronic subdural hematoma with midline shift. An emergency Burr hole drainage for hematoma was performed. Headache recurred 6 days later. MRI of the brain reve... | ['Adult', 'Biopsy', 'Brain', 'Drainage', 'Dura Mater', 'Hematoma, Subdural, Chronic', 'Humans', 'Hypertrophy', 'Immunoglobulin G', 'Intracranial Hypertension', 'Magnetic Resonance Imaging', 'Male', 'Meningitis', 'Steroids', 'Tomography, X-Ray Computed'] | 28,087,916 | [['M01.060.116'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['A08.186.211'], ['E02.309', 'E04.237'], ['A08.186.566.395'], ['C10.228.140.300.535.450.400.120', 'C10.900.300.837.600.120', 'C14.907.253.573.400.450.120', 'C2... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Does individual psychotherapy have a place in the treatment of schizophrenia?]. | Psychotherapy of schizophrenia has caused considerable debate. In 1990 prominent researchers proposed "a moratorium" on such treatment. It is now generally accepted that neuroleptic drugs cannot eliminate the need for comprehensive training in practical and social skills in patients with schizophrenia and that most pat... | ['Antipsychotic Agents', 'Humans', 'Patient Care Planning', 'Psychotherapy', 'Schizophrenia'] | 12,426,900 | [['D27.505.696.277.950.040', 'D27.505.954.427.210.950.040', 'D27.505.954.427.700.872.331'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N04.590.233.624'], ['F04.754'], ['F03.700.750']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Health Care [N]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Improving detection of intraoperative medical errors (iMEs) and intraoperative adverse events (iAEs) and their contribution to postoperative outcomes. | Our knowledge of the types of intraoperative patient safety events, their harm to patients, and relationship to postoperative complications is sparse. This study examined intraoperative medical errors (iMEs) and intraoperative adverse events (iAEs) voluntarily reported by providers using two programs at our hospital: s... | ['Databases, Factual', 'Humans', 'Intraoperative Complications', 'Medical Errors', 'Morbidity', 'Patient Safety', 'Postoperative Complications', 'Quality Improvement', 'Retrospective Studies', 'Risk Management', 'Surgical Procedures, Operative', 'United States'] | 29,563,021 | [['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.505'], ['N02.421.450'], ['E05.318.308.985.525', 'N01.224.935.597', 'N06.850.505.400.975.525', 'N06.850.520.308.985.525'], ['N06.850.135.060.075.399'], ['C23.550.767'], ['J01.293.754', 'N04.761.744'], ['E05.31... | ['Information Science [L]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 |
Use of low-cost video recording device in reflective practice in cataract surgery. | Reflective surgical practice is invaluable for surgeons at all levels of experience. For trainees in particular, every surgical opportunity must be optimized for its learning potential. Recording and reviewing cataract surgery is an invaluable tool. We describe a video recording device that has the advantages of ease o... | ['Cataract Extraction', 'Humans', 'Internship and Residency', 'Ophthalmology', 'Video Recording'] | 20,362,842 | [['E04.540.825.249'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I02.358.337.350.500', 'I02.358.399.350.750'], ['H02.403.810.468'], ['L01.280.960']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Disciplines and Occupations [H]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 |
The uptake and fate of vanadyl ion in ascidian blood cells and a detailed hypothesis for the mechanism and location of biological vanadium reduction. A visible and X-ray absorption spectroscopic study. | Vanadium K-edge X-ray absorption spectroscopy (XAS) has been used to track the uptake and fate of VO(2+) ion in blood cells from Ascidia ceratodes, following exposure to dithiothreitol (DTT) or to DTT plus VO(2+). The full range of endogenous vanadium was queried by fitting the XAS of blood cells with the XAS spectra o... | ['Animals', 'Spectrum Analysis', 'Urochordata', 'Vanadates', 'X-Rays'] | 18,234,345 | [['B01.050'], ['E05.196.867'], ['B01.050.150.200.727', 'B01.050.500.272.727'], ['D01.248.497.158.952', 'D01.960.960'], ['G01.358.500.505.970', 'G01.750.250.970', 'G01.750.750.918']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Modifications of small intestine lysosomal enzymes after irradiation at different times of the day. | The modification of lysosomal enzyme activities in animals irradiated with the same sublethal dose at 4 different times of the day is reported. The results confirmed the absence of circadian fluctuations in all the lysosomal enzymes and in protein content. A difference in behaviour between acid beta-galactosidase and b... | ['Acid Phosphatase', 'Cathepsins', 'Circadian Rhythm', 'Glucuronidase', 'Humans', 'Intestine, Small', 'Lysosomes', 'Radiation Injuries', 'beta-Galactosidase'] | 6,283,798 | [['D08.811.277.352.650.025'], ['D08.811.277.656.224'], ['G07.180.562.190'], ['D08.811.277.450.426'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A03.556.124.684'], ['A11.284.430.214.190.875.190.550'], ['C26.733', 'G01.750.748.500', 'N06.850.460.350.850.500', 'N06.850.810.300.360'], ['D08.811.277.450.410.100']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Ambulance 12-lead electrocardiography transmission via cell phone technology to cardiologists. | This study demonstrates transmission of 12-lead electrocardiography (ECG) in an ambulance to the cell phone of the attendant emergency medical technician and then to the hospital and to cell phones of off-site cardiologists. The emergency medical technician cell phone receives Extensible Markup Language files generated... | ['Ambulances', 'Body Surface Potential Mapping', 'Cardiology', 'Cell Phone', 'Emergency Medical Technicians', 'Emergency Service, Hospital', 'Humans', 'Taiwan', 'Telemedicine', 'Wireless Technology'] | 20,925,562 | [['J01.937.500.050', 'N02.421.297.879.100'], ['E01.370.370.380.240.850.100', 'E01.370.405.240.850.100'], ['H02.403.429.163'], ['L01.178.847.698.300'], ['M01.526.373.250', 'M01.526.485.067.150', 'N02.360.067.150'], ['N02.278.216.500.968.336', 'N02.421.297.195', 'N04.452.442.452.422.336'], ['B01.050.150.900.649.313.988.4... | ['Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Information Science [L]', 'Named Groups [M]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 1 |
Proteomic analysis of the acid-soluble nacre matrix of the bivalve Unio pictorum: detection of novel carbonic anhydrase and putative protease inhibitor proteins. | The matrix extracted from mollusc shell nacre is a mixture of proteins and glycoproteins that is thought to play a major role in controlling biomineral synthesis and in increasing its mechanical properties. We investigated the nacreous shell of the freshwater mussel Unio pictorum, to which we applied a proteomics appro... | ['Amino Acid Sequence', 'Animals', 'Carbonic Anhydrases', 'Chromatography, Liquid', 'Databases, Protein', 'Molecular Sequence Data', 'Protease Inhibitors', 'Proteome', 'Sequence Analysis, Protein', 'Spectrometry, Mass, Electrospray Ionization', 'Unio'] | 20,815,006 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D08.811.520.241.300.150'], ['E05.196.181.400'], ['L01.313.500.750.300.188.400.300.750', 'L01.313.500.750.300.188.400.325.710', 'L01.470.750.750.300.750', 'L01.470.750.750.325.710'], ['L01.453.245.667'], ['D27.505.519.389.745'], ['D12.776.817'], ['E05.393.760.7... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
The role of plants and plant/microbial systems in the reduction of exposure. | The activities of plants and plant/microbial associations may offer a viable means of accomplishing the in situ remediation of contaminated soils. Two uses of plants for phytoremediation are reported here. In one set of studies, the ability of plants to foster degradative microorganisms was investigated. Results indica... | ['Biodegradation, Environmental', 'Environmental Exposure', 'Humans', 'Metals', 'Plant Physiological Phenomena', 'Plant Roots', 'Soil Microbiology', 'Soil Pollutants', 'Xenobiotics'] | 8,565,900 | [['N06.230.080.600.500', 'N06.850.460.375.500'], ['N06.850.460.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.552'], ['G15'], ['A18.400'], ['H01.158.273.540.274.555', 'N06.850.425.300'], ['D27.888.284.756'], ['D26.969']] | ['Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
An aggressive protocol of ESWL and dissolution therapy of gallbladder stones. | OBJECTIVES: to assess the overall efficacy and which factors are independent predictors of success of ESWL and oral dissolution therapy of gallbladder stones using an aggressive protocol (high energy shock waves -median 22 Kv- and allowance to up to 6 sessions with an electro-hydraulic lithotripter).PATIENTS AND METHOD... | ['Age Factors', 'Body Mass Index', 'Cholelithiasis', 'Combined Modality Therapy', 'Disease-Free Survival', 'Female', 'Follow-Up Studies', 'Gastrointestinal Agents', 'Humans', 'Lithotripsy', 'Male', 'Middle Aged', 'Proportional Hazards Models', 'Prospective Studies', 'Sex Factors', 'Time Factors', 'Treatment Outcome', '... | 7,590,575 | [['N05.715.350.075', 'N06.850.490.250'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['C06.130.409'], ['E02.186'], ['E01.789.800.190', 'E05.318.740.998.300', 'N04.761.559.590.800.190', 'N05.715.360.575.575.800.190', 'N05.715.360.750.795.300', 'N06.850.520.830.998.300'],... | ['Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Evolution of an altruistic trait through group selection as studied by the diffusion equation method. | A diffusion model is formulated which incorporates the process of group selection (i.e. interdeme competition) in addition to mutation, migration, individual selection, and random genetic drift. A condition is obtained for group selection to prevail over individual selection in the evolution of an altruistic trait. Let... | ['Biometry', 'Gene Frequency', 'Models, Genetic', 'Mutation', 'Selection, Genetic'] | 6,600,088 | [['E05.318.740.225', 'N06.850.505.200'], ['G05.330'], ['E05.599.395.397'], ['G05.365.590'], ['G05.783']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[Outcome of various inpatient lymph drainage procedures]. | Three groups of patients (n: 10 each group) with extensive or massive secondary lymphedema of the arm were treated with different types of manual lymphatic drainage. The decrease of volume based on arm circumference was measured before and four weeks after treatment. The first group received one hour of manual lymph dr... | ['Aged', 'Aged, 80 and over', 'Arm', 'Bandages', 'Drainage', 'Female', 'Follow-Up Studies', 'Humans', 'Lymphedema', 'Middle Aged', 'Physical Therapy Modalities', 'Time Factors', 'Treatment Outcome'] | 8,768,046 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['A01.378.800.075'], ['E07.101'], ['E02.309', 'E04.237'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C15.604.496'], ['M01.060.116.630'], ['E02.779', 'E02.831.535'], ['G01.910... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Intraobserver and interobserver consistency for grading esophagitis with narrow-band imaging. | BACKGROUND: Narrow-band imaging (NBI) is a novel, noninvasive optical technique that adjusts reflected light to enhance the contrast between the esophageal mucosa and the gastric mucosa. Whether the use of this optical technique may increase consistency in describing the presence and severity of mucosal breaks remains ... | ['Esophagitis', 'Esophagoscopy', 'Esophagus', 'Gastric Mucosa', 'Humans', 'Mucous Membrane', 'Observer Variation', 'Video Recording'] | 17,643,694 | [['C06.405.117.620', 'C06.405.205.663'], ['E01.370.372.250.250.275', 'E01.370.388.250.250.250.260', 'E04.210.240.250.260', 'E04.502.250.250.250.260'], ['A03.556.875.500'], ['A03.556.875.875.440', 'A10.615.550.291'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A10.615.550'], ['E01.354.753', 'N02.421.450.600', 'N0... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Health Care [N]', 'Information Science [L]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Hypovitaminosis D in adolescent females--an analytical cohort study in the United Arab Emirates. | BACKGROUND: Despite living in a sunny country, hypovitaminosis D is common in women of reproductive age in Al Ain, United Arab Emirates (UAE).AIMS AND OBJECTIVES: To establish the prevalence of hypovitaminosis D in adolescent female Emirati nationals and its risk factors.METHODS: This was an analytical prospective coho... | ['Adolescent', 'Child', 'Cholecalciferol', 'Cohort Studies', 'Cross-Sectional Studies', 'Ergocalciferols', 'Female', 'Humans', 'Luminescent Measurements', 'Prevalence', 'Prospective Studies', 'United Arab Emirates', 'Vitamin D Deficiency'] | 25,547,176 | [['M01.060.057'], ['M01.060.406'], ['D04.210.500.247.222.159', 'D04.210.500.247.808.146', 'D04.210.500.812.768.196', 'D10.570.938.146'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['D04.210.500.247.222.474... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Seasonal changes in liver and serum proteins, serum calcium, inorganic phosphate and magnesium levels in relation to vitellogenesis in a freshwater catfish, Heteropneustes fossilis (Bloch). | Female specimens of Heteropneustes fossilis show marked seasonal changes in liver and serum proteins, serum calcium, inorganic phosphate and magnesium levels in relation to the ovarian cycle. Their levels increase with the ovarian maturation, record the maximum values during the prespawning phase and gradually decline ... | ['Analysis of Variance', 'Animals', 'Blood Proteins', 'Calcium', 'Catfishes', 'Female', 'Liver', 'Magnesium', 'Phosphates', 'Proteins', 'Seasons', 'Vitellogenesis'] | 7,857,087 | [['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['B01.050'], ['D12.776.124'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['B01.050.150.900.493.080'], ['A03.620'], ['D01.268.552.437', 'D01.268.557.500', 'D01.552.547.500'], ['D01.029.260.700.675.374', 'D01.248.497.158.730', 'D01.695.625.67... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Pathological observation on experimental swine dysentery. | Experimental swine dysentery caused by 4 cultured strains (S73/2, DJ183, DJ70 and DK762) of Treponema hyodysenteriae was studied pathologically. The distribution and quantity of treponemes were examined on tissue sections stained by the Warthin-Starry method. Of the organs the colon contained the largest number of trep... | ['Animals', 'Colon', 'Dysentery', 'Intestinal Mucosa', 'Swine', 'Swine Diseases', 'Treponemal Infections'] | 522,890 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Significance of positive and negative syndromes in chronic schizophrenia. | Positive and negative syndromes were studied in relation to demographic, historical, genealogical, clinical, psychometric, extrapyramidal, and follow-up measures of 101 chronic schizophrenic patients. The criterion scales proved to be reliable, normally distributed, and strongly correlated with general psychopathology,... | ['Adult', 'Aged', 'Chronic Disease', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Middle Aged', 'Neuropsychological Tests', 'Psychiatric Status Rating Scales', 'Regression Analysis', 'Schizophrenia', 'Schizophrenic Psychology', 'Syndrome'] | 3,814,927 | [['M01.060.116'], ['M01.060.116.100'], ['C23.550.291.500'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['F04.711.513'], ['F04.711.513.653'], ['E05.318.740.750', 'N05.715.360.750.695', 'N06.850.520.830.7... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Prognostic significance of using solid versus whole tumor size on high-resolution computed tomography for predicting pathologic malignant grade of tumors in clinical stage IA lung adenocarcinoma: a multicenter study. | OBJECTIVES: The present multicenter study compared the usefulness of the solid tumor size with that of the whole tumor size on preoperative high-resolution computed tomography for predicting pathologic high-grade malignancy (positive lymphatic, vascular, or pleural invasion) and the prognosis of clinical stage IA lung ... | ['Adenocarcinoma', 'Adenocarcinoma of Lung', 'Aged', 'Disease-Free Survival', 'Female', 'Fluorodeoxyglucose F18', 'Humans', 'Japan', 'Kaplan-Meier Estimate', 'Logistic Models', 'Lung Neoplasms', 'Male', 'Middle Aged', 'Multimodal Imaging', 'Neoplasm Grading', 'Neoplasm Staging', 'Positron-Emission Tomography', 'Predict... | 22,104,678 | [['C04.557.470.200.025'], ['C04.557.470.200.025.022', 'C04.588.894.797.520.055'], ['M01.060.116.100'], ['E01.789.800.190', 'E05.318.740.998.300', 'N04.761.559.590.800.190', 'N05.715.360.575.575.800.190', 'N05.715.360.750.795.300', 'N06.850.520.830.998.300'], ['D09.254.229.500'], ['B01.050.150.900.649.313.988.400.112.40... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Geographicals [Z]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Paneth cell ablation in the presence of Klebsiella pneumoniae induces necrotizing enterocolitis (NEC)-like injury in the small intestine of immature mice. | Necrotizing enterocolitis (NEC) is a leading cause of morbidity and mortality in premature infants. During NEC pathogenesis, bacteria are able to penetrate innate immune defenses and invade the intestinal epithelial layer, causing subsequent inflammation and tissue necrosis. Normally, Paneth cells appear in the intesti... | ['Aging', 'Animals', 'Cell Differentiation', 'Cytoplasmic Granules', 'Disease Models, Animal', 'Dithizone', 'Enteral Nutrition', 'Enterocolitis, Necrotizing', 'Humans', 'Infant, Newborn', 'Inflammation', 'Intestine, Small', 'Klebsiella pneumoniae', 'Mice', 'Paneth Cells', 'Zinc'] | 22,328,592 | [['G07.345.124'], ['B01.050'], ['G04.152'], ['A11.284.430.214.190.500', 'A11.284.430.214.190.875.190.190'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['D02.172.530', 'D02.442.726.200'], ['E02.421.360', 'E02.642.500.360'], ['C06.405.205.596.700', 'C06.405.469.363.700'], ['B01.050.150.900.649.313.988.400.112.400.400... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Named Groups [M]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The dual-use dilemma for the life sciences: perspectives, conundrums, and global solutions. | The term "dual-use" traditionally has been used to describe technologies that could have both civilian and military usage, but this term has at least three different dimensions that pose a dilemma for modern biology and its possible misuse for hostile purposes: (1) ostensibly civilian facilities that are in fact intend... | ['Access to Information', 'Biological Science Disciplines', 'Biological Warfare', 'Biotechnology', 'Containment of Biohazards', 'Diffusion of Innovation', 'Global Health', 'Humans', 'International Cooperation', 'Military Science', 'Public Health', 'Security Measures', 'Social Responsibility'] | 16,999,588 | [['I01.880.604.473.352.500.030', 'L01.143.024', 'L01.737.030'], ['H01.158'], ['I01.880.735.950.500.226'], ['H01.158.550', 'J01.897.120'], ['E05.235', 'N06.850.135.060.075.249'], ['L01.143.320'], ['H02.403.371', 'N01.400.337'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I01.615.500'], ['J01.675'], ['H02.403.720'... | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Information Science [L]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Humani... | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 |
Cancer procoagulant in patients with adenocarcinomas. | Cancer procoagulant (CP) is a cysteine proteinase that may be produced by malignant and foetal tissue. The possible role of CP in the pathogenesis of cancer-related thrombosis has been suggested recently. The purpose of the study was to evaluate coagulation prothrombotic markers and their relation to CP concentration i... | ['Adenocarcinoma', 'Adult', 'Aged', 'Biomarkers', 'Blood Proteins', 'Colonic Neoplasms', 'Cysteine Endopeptidases', 'Female', 'Humans', 'Male', 'Middle Aged', 'Neoplasm Proteins', 'Partial Thromboplastin Time', 'Predictive Value of Tests', 'Risk Factors', 'Stomach Neoplasms', 'Venous Thrombosis'] | 16,269,926 | [['C04.557.470.200.025'], ['M01.060.116'], ['M01.060.116.100'], ['D23.101'], ['D12.776.124'], ['C04.588.274.476.411.307.180', 'C06.301.371.411.307.180', 'C06.405.249.411.307.180', 'C06.405.469.158.356.180', 'C06.405.469.491.307.180'], ['D08.811.277.656.262.500', 'D08.811.277.656.300.200'], ['B01.050.150.900.649.313.988... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Photoactivation of Drosophila melanogaster | Cryptochromes are blue-light photoreceptor proteins, which provide input to circadian clocks. The cryptochrome from Drosophila melanogaster (DmCry) modulates the degradation of Timeless and itself. It is unclear how light absorption by the chromophore and the subsequent redox reactions trigger these events. Here, we us... | ['Animals', 'Catalytic Domain', 'Cryptochromes', 'Drosophila melanogaster', 'Hydrogen Bonding', 'Hydrogen-Ion Concentration', 'Light', 'Models, Biological', 'Molecular Dynamics Simulation', 'Protein Conformation', 'Signal Transduction', 'Spectrum Analysis', 'Structure-Activity Relationship'] | 31,328,161 | [['B01.050'], ['G02.111.570.120.704', 'G02.111.570.820.709.275.750.188'], ['D12.644.360.138.150', 'D12.776.331.180', 'D12.776.476.156.250', 'D12.776.765.593.500'], ['B01.050.500.131.617.720.500.500.750.310.250.500'], ['G02.282'], ['G02.300'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'],... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Synthetic tetrapeptides related to dermorphin: potent long lasting analgesic action following subcutaneous administration. | To examine the opioid properties of D-MetO2-dermorphin tetrapeptides, eight new analogues based on the following formula, X-Tyr-D-MetO-Phe-aa-Y, were prepared. All these peptides show dose-related naloxone-reversible opioid effects in vitro and in vivo. Substitution of Sar or Gly-ol for Gly4 were well tolerated by the ... | ['Amino Acid Sequence', 'Analgesics', 'Animals', 'Biological Assay', 'Guinea Pigs', 'In Vitro Techniques', 'Injections, Subcutaneous', 'Oligopeptides', 'Opioid Peptides', 'Structure-Activity Relationship'] | 3,831,956 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D27.505.696.663.850.014', 'D27.505.954.427.040'], ['B01.050'], ['E05.091'], ['B01.050.150.900.649.313.992.550'], ['E05.481'], ['E02.319.267.530.620'], ['D12.644.456'], ['D12.644.400.575', 'D12.776.631.650.575'], ['G02.111.830', 'G07.690.773.997']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Gastroparesis and jejunal feeding. | A kidney transplant patient with diabetic gastroparesis was effectively treated by jejunal feeding. The patient, a 31-year-old woman, has a complicated medical history, with insulin-dependent diabetes mellitus. Complications include kidney failure followed by transplantation, bilateral knee amputations, and being regis... | ['Adult', 'Diabetes Mellitus, Type 1', 'Diabetic Nephropathies', 'Diabetic Retinopathy', 'Enteral Nutrition', 'Female', 'Gastroparesis', 'Gastrostomy', 'Humans', 'Jejunum', 'Treatment Outcome'] | 10,528,053 | [['M01.060.116'], ['C18.452.394.750.124', 'C19.246.267', 'C20.111.327'], ['C12.777.419.192', 'C13.351.968.419.192', 'C19.246.099.875'], ['C11.768.257', 'C14.907.320.382', 'C19.246.099.500.382'], ['E02.421.360', 'E02.642.500.360'], ['C06.405.748.543', 'C23.888.592.636.263'], ['E04.210.496', 'E04.579.408'], ['B01.050.150... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Partial complementation of a DNA ligase I deficiency by DNA ligase III and its impact on cell survival and telomere stability in mammalian cells. | DNA ligase I (LigI) plays a central role in the joining of strand interruptions during replication and repair. In our current study, we provide evidence that DNA ligase III (LigIII) and XRCC1, which form a complex that functions in single-strand break repair, are required for the proliferation of mammalian LigI-deplete... | ['Animals', 'Blotting, Western', 'Cell Survival', 'Cells, Cultured', 'Chromatin', 'Colony-Forming Units Assay', 'DNA Damage', 'DNA Ligase ATP', 'DNA Ligases', 'DNA Repair', 'DNA Replication', 'DNA-Binding Proteins', 'Embryo, Mammalian', 'Fibroblasts', 'Fluorescent Antibody Technique', 'Genetic Complementation Test', 'H... | 22,460,582 | [['B01.050'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['G04.346'], ['A11.251'], ['A11.284.430.106.279.345.190.160.180', 'D12.776.664.224', 'G05.360.160.180'], ['E01.370.225.500.383', 'E05.200.500.383', 'E05.242.383'], ['G05.200'], ['D08.811.074.500.500', 'D08... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Older adult users of outpatient mental health services. | Descriptive demographic, clinical and interview data from clients of an outpatient mental health clinic for older adults are presented. These clients are better educated and have a more frequent history of marital difficulties than older adults in general. Although a significant minority received V code and Adjustment ... | ['Aged', 'Community Mental Health Services', 'Educational Status', 'Female', 'Health Services for the Aged', 'Humans', 'Male', 'Marriage', 'Middle Aged'] | 2,019,100 | [['M01.060.116.100'], ['F04.408.307', 'N02.421.143.183', 'N02.421.461.232'], ['N01.824.196'], ['N02.421.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.263.315.500.500', 'I01.240.361.500.500', 'I01.880.853.150.423.500.500', 'N01.224.361.500.500', 'N01.824.308.500.500'], ['M01.060.116.630']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
The lack of transmission of NANB/C hepatitis between acute and chronically infected patients and their heterosexual partners. | In order to study the risk of heterosexual transmission of non-A, non-B/C (NANB/C) hepatitis, 34 spouses and/or sexual partners to 34 index patients (13 women, 21 men; median age 39 years) with acute NANB/C hepatitis (anti-HCV positive 13/34) were repeatedly tested for antibodies to hepatitis C virus (anti-HCV) and ser... | ['Acute Disease', 'Adult', 'Aged', 'Alanine Transaminase', 'Chronic Disease', 'Female', 'Follow-Up Studies', 'Hepatitis Antibodies', 'Hepatitis C', 'Humans', 'Male', 'Middle Aged', 'Probability', 'Risk Factors', 'Sexual Behavior', 'Sexual Partners', 'Sexually Transmitted Diseases', 'Substance Abuse, Intravenous', 'Tran... | 1,957,126 | [['C23.550.291.125'], ['M01.060.116'], ['M01.060.116.100'], ['D08.811.913.477.700.100'], ['C23.550.291.500'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['D12.776.124.486.485.114.254.450', 'D12.776.124.790.651.114.254.450', 'D12.776.377.715.548.114.254.450'], ['C01.221.25... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Can subtypes of contact lens-associated corneal infiltrative events be clinically differentiated? | PURPOSE: A schema has recently been described for clinical differentiation among 4 symptomatic subtypes of contact lens-associated corneal infiltrative events (CIEs): microbial keratitis (MK), contact lens-induced peripheral ulcer (CLPU), contact lens-induced acute red eye (CLARE), and infiltrative keratitis (IK). The ... | ['Contact Lenses', 'Cornea', 'Corneal Ulcer', 'Diagnosis, Differential', 'Diagnostic Techniques, Ophthalmological', 'Humans', 'Keratitis', 'Prospective Studies', 'Severity of Illness Index'] | 16,783,142 | [['E07.632.500.276'], ['A09.371.060.217'], ['C01.375.177', 'C11.204.564.225', 'C11.294.177'], ['E01.171'], ['E01.370.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C11.204.564'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['E05.318.308.980.438.475.456.500', 'N0... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[Blood oxygenation in patients with arterial occlusive diseases of the lower limbs]. | The examination of 25 patients after intraarterial infusions of hydrogen peroxide has shown that temporary oxygen supersaturation of blood can improve the oxygenation of tissues. | ['Adult', 'Arteriosclerosis Obliterans', 'Endarteritis', 'Femoral Artery', 'Humans', 'Hydrogen Peroxide', 'Hypoxia', 'Infusions, Intra-Arterial', 'Ischemia', 'Leg', 'Middle Aged', 'Oxygen'] | 4,090,189 | [['M01.060.116'], ['C14.907.137.126.114'], ['C14.907.940.090.340'], ['A07.015.114.351'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.248.497.158.685.750.424', 'D01.339.431.374.424', 'D01.650.550.750.400', 'D02.389.338.253'], ['C23.888.852.079'], ['E02.319.267.510.520'], ['C23.550.513'], ['A01.378.610.500'], ... | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Massive endometriosis in two rhesus monkeys. | Massive endometriosis was found in two rhesus monkeys during a chronic toxicological experiment. These cases had metastatic lesions in lymph nodes in addition to the foci on the serosal wall of pelvic organs. Invasion to the intestinal mucosal layer was also noted in a case. These observation indicated that endometrios... | ['Animals', 'Endometriosis', 'Intestinal Neoplasms', 'Lymphatic Metastasis', 'Macaca mulatta', 'Monkey Diseases', 'Urinary Bladder Neoplasms'] | 2,792,209 | [['B01.050'], ['C13.351.500.163'], ['C04.588.274.476.411', 'C06.301.371.411', 'C06.405.249.411', 'C06.405.469.491'], ['C04.697.650.560', 'C23.550.727.650.560'], ['B01.050.150.900.649.313.988.400.112.199.120.510.550'], ['C22.735.500'], ['C04.588.945.947.960', 'C12.758.820.968', 'C12.777.829.813', 'C13.351.937.820.945', ... | ['Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Percutaneous mitral valve repair with MitraClip for severe functional mitral regurgitation. | A 67-year-old Chinese woman with comorbidities of chronic obstructive lung disease, hypertension and prior coronary artery bypass surgery presented with severe functional mitral regurgitation (MR) and severely depressed left ventricular function. She was in New York Heart Association (NYHA) Class II-III. Due to high su... | ['Aged', 'Cardiac Surgical Procedures', 'Cardiology', 'Catheters', 'Echocardiography', 'Equipment and Supplies', 'Female', 'Heart Ventricles', 'Humans', 'Mitral Valve', 'Mitral Valve Insufficiency', 'Pulmonary Disease, Chronic Obstructive', 'Risk', 'Ultrasonography, Doppler', 'Ventricular Dysfunction, Left'] | 23,338,929 | [['M01.060.116.100'], ['E04.100.376', 'E04.928.220'], ['H02.403.429.163'], ['E07.132'], ['E01.370.350.130.750', 'E01.370.350.850.220', 'E01.370.370.380.220'], ['E07'], ['A07.541.560'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A07.541.510.507'], ['C14.280.484.461'], ['C08.381.495.389'], ['E05.318.740.600.800',... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Efficacy and tolerability of two different formulations of atorvastatin in Korean patients with hypercholesterolemia: a multicenter, prospective, randomized clinical trial. | PURPOSE: This study was designed to compare the efficacy and tolerability of the generic formulation (Atorva®) and the reference formulation (Lipitor®) of atorvastatin, both at a dosage of 20 mg once daily.METHODS: This study was a prospective open-label, randomized controlled study. Hypercholesterolemic patients who h... | ['Atorvastatin', 'Drug Administration Schedule', 'Drug Compounding', 'Drug Tolerance', 'Female', 'Humans', 'Hypercholesterolemia', 'Male', 'Middle Aged', 'Molecular Conformation', 'Prospective Studies', 'Republic of Korea'] | 28,814,835 | [['D03.383.129.578.075', 'D10.251.450.200'], ['E02.319.283'], ['E05.916.270'], ['G07.690.773.992'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C18.452.584.500.500.396'], ['M01.060.116.630'], ['G02.111.570.820'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['Z01.252... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Named Groups [M]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Hepatitis C genotyping by denaturing high-performance liquid chromatography. | Determination of the hepatitis C virus (HCV) genotype for infected patients increasingly has become accepted as the standard of care. Genotype assignment helps in assessing disease prognosis and assists in establishing the appropriate duration of treatment. The great genetic diversity of HCV, with 11 major genotypes an... | ["5' Untranslated Regions", 'Base Sequence', 'Chromatography, High Pressure Liquid', 'Genotype', 'Hepacivirus', 'Molecular Sequence Data'] | 14,715,747 | [['D13.444.735.544.875.885', 'D13.444.735.790.878.885', 'G05.360.340.024.220.880.885', 'G05.360.340.024.340.137.910.885'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.196.181.400.300'], ['G05.380'], ['B04.450.380', 'B04.820.578.344.475'], ['L01.453.245.667']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
The 150/30 formulation. Experience in the United Kingdom. | Oral contraceptive agents (OCs) containing levonorgestrel, 150 micrograms, and ethinyl estradiol, 30 micrograms, account for almost half the sales of such agents in the United Kingdom. The remarkable success of this formulation has occurred primarily because it provides extremely low doses of both hormonal constituents... | ['Adult', 'Cardiovascular Diseases', 'Clinical Trials as Topic', 'Contraceptives, Oral', 'Contraceptives, Oral, Combined', 'Contraceptives, Oral, Synthetic', 'Ethinyl Estradiol', 'Female', 'Humans', 'Levonorgestrel', 'Middle Aged', 'Norgestrel', 'Risk', 'Smoking', 'Stereoisomerism', 'United Kingdom'] | 6,403,702 | [['M01.060.116'], ['C14'], ['E05.318.372.250.250', 'N05.715.360.330.250.250', 'N06.850.520.450.250.250'], ['D27.505.696.875.360.276.210', 'D27.505.954.705.360.276.210'], ['D26.310.360', 'D27.505.696.875.360.276.210.100', 'D27.505.954.705.360.276.210.100'], ['D27.505.696.875.360.276.210.443', 'D27.505.954.705.360.276.21... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Aspirin inhibits nuclear factor-kappa B mobilization and monocyte adhesion in stimulated human endothelial cells. | BACKGROUND: The induction of vascular cell adhesion molecule-1 (VCAM-1) and E-selectin by tumor necrosis factor-alpha (TNF) is mediated by mobilization of the transcription factor nuclear factor-kappa B (NF-kappa B). Since salicylates have been reported to inhibit NF-kappa B activation by preventing the degradation of ... | ['Aspirin', 'Cell Adhesion', 'Cell Adhesion Molecules', 'Cells, Cultured', 'E-Selectin', 'Endothelium, Vascular', 'Humans', 'In Vitro Techniques', 'Monocytes', 'NF-kappa B', 'Tumor Necrosis Factor-alpha', 'Vascular Cell Adhesion Molecule-1'] | 7,534,663 | [['D02.455.426.559.389.657.410.595.176'], ['G04.022'], ['D12.776.395.550.200', 'D12.776.543.550.200', 'D23.050.301.350'], ['A11.251'], ['D12.776.395.550.200.700.300', 'D12.776.503.843.300', 'D12.776.543.550.200.700.300', 'D23.050.301.350.700.300'], ['A07.015.700.500', 'A10.272.491.355'], ['B01.050.150.900.649.313.988.4... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Arch index as a predictor of pes planus: a comparative study of indigenous Kenyans and Tanzanians. | We determined the arch index of able-bodied indigenous Kenyan and Tanzanian individuals free of foot pain by using their dynamic footprints to classify the foot arch type and determine the prevalence of pes planus according to a previously described method. Males had a significantly higher arch index than females in bo... | ['Adolescent', 'Child', 'Female', 'Flatfoot', 'Foot', 'Humans', 'Kenya', 'Male', 'Predictive Value of Tests', 'Prevalence', 'Sex Factors', 'Tanzania'] | 15,901,815 | [['M01.060.057'], ['M01.060.406'], ['C05.330.488.655.250', 'C05.330.495.681.250', 'C05.660.585.512.380.813.250', 'C16.131.621.585.512.500.681.250'], ['A01.378.610.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.058.290.120.400'], ['E05.318.370.800.650', 'N05.715.360.325.700.640', 'N06.850.520.445.800.650'... | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Comparison of camera-based 99mTc-MAG3 and 24-hour creatinine clearances for evaluation of kidney function. | OBJECTIVE: The 24-hour creatinine clearance is the standard clinical technique for measuring kidney function; however, this measurement is cumbersome and inconvenient for patients. We hypothesized that a camera-based technetium-99m mercaptoacetyltriglycine (MAG3) clearance obtained simultaneously with a standard MAG3 s... | ['Adult', 'Creatinine', 'Female', 'Humans', 'Kidney', 'Kidney Diseases', 'Kidney Transplantation', 'Male', 'Middle Aged', 'Radionuclide Imaging', 'Radiopharmaceuticals', 'Retrospective Studies', 'Technetium Tc 99m Mertiatide', 'Tissue Donors'] | 16,928,911 | [['M01.060.116'], ['D03.383.129.308.207'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A05.810.453'], ['C12.777.419', 'C13.351.968.419'], ['E02.870.500', 'E04.936.450.485', 'E04.950.774.400'], ['M01.060.116.630'], ['E01.370.350.710', 'E01.370.384.730'], ['D27.505.259.843', 'D27.505.519.871', 'D27.720.470.410.650... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A novel functional domain of Cdc15 kinase is required for its interaction with Tem1 GTPase in Saccharomyces cerevisiae. | Exit from mitosis requires the inactivation of cyclin-dependent kinase (CDK) activity. In the budding yeast Saccharomyces cerevisiae, a number of gene products have been identified as components of the signal transduction network regulating inactivation of CDK (called the MEN, for the mitotic exit network). Cdc15, one ... | ['Amino Acid Sequence', 'Binding Sites', 'Cell Cycle Proteins', 'Fungal Proteins', 'GTP-Binding Proteins', 'Molecular Sequence Data', 'Monomeric GTP-Binding Proteins', 'Mutagenesis', 'Protein Kinases', 'Saccharomyces cerevisiae', 'Saccharomyces cerevisiae Proteins', 'Spindle Apparatus'] | 11,290,702 | [['G02.111.570.060', 'L01.453.245.667.060'], ['G02.111.570.120'], ['D12.776.167'], ['D12.776.354'], ['D08.811.277.040.330.300', 'D12.776.157.325'], ['L01.453.245.667'], ['D08.811.277.040.330.300.400', 'D12.644.360.525', 'D12.776.157.325.515', 'D12.776.476.525'], ['G05.558'], ['D08.811.913.696.620.682'], ['B01.300.107.7... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Caring for the forensic population: recognizing the educational needs of emergency department nurses and physicians. | The Emergency Department (ED) is a point of contact for victims of violence after an act of criminal activity has occurred. Hence, ED clinicians are in a key position to have a significant impact on both the medical and legal outcomes of the forensic patient population. The purpose of this study was to describe and com... | ['Adult', 'Clinical Competence', 'Emergency Medicine', 'Emergency Nursing', 'Emergency Service, Hospital', 'Female', 'Forensic Sciences', 'Humans', 'Male', 'Medical Staff, Hospital', 'Middle Aged', 'Needs Assessment', 'New England', 'Nursing Staff, Hospital', 'Surveys and Questionnaires', 'Young Adult'] | 23,176,357 | [['M01.060.116'], ['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['H02.403.250'], ['H02.478.676.200', 'N02.421.533.200'], ['N02.278.216.500.968.336', 'N02.421.297.195', 'N04.452.442.452.422.336'], ['I01.198.780'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.526.485.630.490', 'M01.526.485.740.422', 'N02.3... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Real-life outcome of anti-tumor necrosis factor á in the ambulatory treatment of ulcerative colitis. | AIM: To evaluate the outcome of anti-tumor necrosis factor alpha (anti-TNFá) therapy in outpatients with ulcerative colitis at a tertiary referral center.METHODS: All patients with a confirmed diagnosis of ulcerative colitis undergoing therapy with infliximab and/or adalimumab at the outpatient clinic for inflammatory ... | ['Adalimumab', 'Adolescent', 'Adult', 'Aged', 'Ambulatory Care', 'Anti-Inflammatory Agents', 'Colectomy', 'Colitis, Ulcerative', 'Drug Resistance', 'Drug Substitution', 'Drug Therapy, Combination', 'Female', 'Germany', 'Hospitals, University', 'Humans', 'Infliximab', 'Male', 'Middle Aged', 'Remission Induction', 'Retro... | 25,805,935 | [['D12.776.124.486.485.114.224.060.250', 'D12.776.124.790.651.114.224.060.250', 'D12.776.377.715.548.114.224.200.250'], ['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['E02.760.106', 'N02.421.585.106'], ['D27.505.954.158'], ['E04.210.219'], ['C06.405.205.265.231', 'C06.405.205.731.249', 'C06.405.469.158.188.231... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Elevated marrow inflammatory cells and osteoclasts in subchondral osteosclerosis in human knee osteoarthritis. | Subchondral osteosclerosis, characterized by an increase of hypomineralized bone material, is a pathological hallmark of osteoarthritis. The cellular components in the subchondral marrow compartment that participate in this aberrant bone remodeling process remain to be elucidated. This study assessed the presence of ma... | ['Aged', 'Aged, 80 and over', 'Bone Marrow', 'Culture Media, Conditioned', 'Female', 'Humans', 'Male', 'Osteoarthritis, Knee', 'Osteoblasts', 'Osteoclasts', 'Osteosclerosis', 'Retrospective Studies'] | 26,250,062 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['A15.382.216'], ['D27.720.470.305.250', 'E07.206.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C05.550.114.606.500', 'C05.799.613.500'], ['A11.329.629'], ['A11.329.372.700', 'A11.627.482.700'], ['C05.116.099.708.702'], ['E05.318.372.500.500.500', 'E05.318.372.... | ['Named Groups [M]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
IgG subclass responses to Pseudomonas aeruginosa a- and b-type flagellins in patients with cystic fibrosis: a prospective study. | Sera from 20 cystic fibrosis patients, whose lungs were colonised by Pseudomonas aeruginosa, were examined in a 3-5-year prospective study for any relationship between IgG subclass antibody levels to P. aeruginosa a- and b-type flagellins and pulmonary function (FEV1 and radiological score). Patients were divided into ... | ['Adolescent', 'Adult', 'Antibodies, Bacterial', 'Antigens, Bacterial', 'Child', 'Cystic Fibrosis', 'Electrophoresis, Polyacrylamide Gel', 'Enzyme-Linked Immunosorbent Assay', 'Female', 'Flagellin', 'Forced Expiratory Volume', 'Humans', 'Immunoblotting', 'Immunoglobulin G', 'Lung', 'Male', 'Prospective Studies', 'Pseud... | 7,562,988 | [['M01.060.057'], ['M01.060.116'], ['D12.776.124.486.485.114.107', 'D12.776.124.790.651.114.125', 'D12.776.377.715.548.114.125'], ['D23.050.161'], ['M01.060.406'], ['C06.689.202', 'C08.381.187', 'C16.320.190', 'C16.614.213'], ['E05.196.401.402', 'E05.301.300.319'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.47... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Pattern of connexin 26 (GJB2) mutations causing sensorineural hearing impairment in Ghana. | Mutations of the connexin 26 gene (GJB2) were studied in 365 apparently unrelated individuals with profound nonsyndromic, sensorineural hearing impairment from Ghana, West Africa. Among 121 mutated chromosomes found, 110 carried the previously described R143W mutation. A total of 6 novel mutations: L79P, V178A, R184Q, ... | ['Adolescent', 'Adult', 'Child', 'Connexin 26', 'Connexins', 'Genes, Dominant', 'Genes, Recessive', 'Genetic Testing', 'Genotype', 'Ghana', 'Hearing Loss, Sensorineural', 'Humans', 'Mutation', 'Mutation, Missense'] | 11,439,000 | [['M01.060.057'], ['M01.060.116'], ['M01.060.406'], ['D12.776.543.585.250.100'], ['D12.776.543.585.250'], ['G05.360.340.024.340.240', 'G05.420.320'], ['G05.360.340.024.340.415', 'G05.420.325'], ['E01.370.225.562', 'E05.200.562', 'E05.393.435', 'N02.421.308.430', 'N02.421.726.233.221'], ['G05.380'], ['Z01.058.290.190.32... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Lactose malabsorption among the Pima indians of Arizona. | Lactose loading tests and other means were used to determine the pattern of primary "adult" lactose malabsorption (LM) and milk use among 171 subjects, including 122 children and 49 adults, almost all of them Pima Indians of Arizona. LM develops at quite young ages in full-blooded Pima children: already in the 3- to 4-... | ['Adolescent', 'Adult', 'Age Factors', 'Animals', 'Arizona', 'Child', 'Child, Preschool', 'Feeding Behavior', 'Female', 'Genes, Dominant', 'Humans', 'Indians, North American', 'Infant', 'Lactose Intolerance', 'Lactose Tolerance Test', 'Male', 'Milk', 'Pedigree'] | 578,795 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['B01.050'], ['Z01.107.567.875.760.100'], ['M01.060.406'], ['M01.060.406.448'], ['F01.145.113.547', 'F01.145.407', 'G07.203.650.353'], ['G05.360.340.024.340.240', 'G05.420.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.686.508.150... | ['Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
Microbleeds and free active MMP-9 are independent risk factors for neurological deterioration in acute lacunar stroke. | BACKGROUND AND PURPOSE: in this prospective study, we evaluated mutual relationships amongst microbleeds, matrix metalloproteinase-9 (MMP-9) and neurological deterioration in patients with their first acute lacunar stroke.METHODS: based on diffusion-weighted image findings, we recruited 206 patients with their first ac... | ['Aged', 'Analysis of Variance', 'Brain', 'Cerebral Hemorrhage', 'Disease Progression', 'Enzyme-Linked Immunosorbent Assay', 'Female', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Matrix Metalloproteinase 9', 'Middle Aged', 'Prognosis', 'Prospective Studies', 'Regression Analysis', 'Risk Factors', 'Severity of Illn... | 20,550,564 | [['M01.060.116.100'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['A08.186.211'], ['C10.228.140.300.535.200', 'C14.907.253.573.200', 'C23.550.414.913.100'], ['C23.550.291.656'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], [... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A versatile in vivo chamber angiogenesis assay for measuring anti-angiogenic activity in mice. | We recently described an in vivo angiogenesis assay for rats--an optimized Matrigel plug assay based on subcutaneously implanted chambers with fixed volume and shape. Here we examine the possibility of switching the host animal from rat to mouse, thereby reducing the requirement for test compound an order of magnitude.... | ['Angiogenesis Inhibitors', 'Animals', 'Female', 'Fibroblast Growth Factor 2', 'Mice', 'Mice, Inbred BALB C', 'Mice, Inbred C57BL', 'Mice, Nude', 'Neovascularization, Pathologic'] | 14,719,059 | [['D27.505.696.377.077.099', 'D27.505.696.377.450.100', 'D27.505.954.248.025'], ['B01.050'], ['D12.644.276.624.120', 'D12.776.467.624.120', 'D23.529.624.120'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.338', 'B01.050.150.900.649.313.992.635.505.500.400.338'], ['B01.050.050.199.520.520.420',... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Characterization and plasma measurement of the WE-14 peptide in patients with pheochromocytoma. | Granins and their derived peptides are valuable circulating biological markers of neuroendocrine tumors. The aim of the present study was to investigate the tumoral chromogranin A (CgA)-derived peptide WE-14 and the potential advantage to combine plasma WE-14 detection with the EM66 assay and the existing current CgA a... | ['Adrenal Gland Neoplasms', 'Adult', 'Aged', 'Biomarkers', 'Chromaffin Cells', 'Chromogranin A', 'Female', 'Gene Expression Regulation, Neoplastic', 'Healthy Volunteers', 'Humans', 'Male', 'Middle Aged', 'Mutation', 'Neoplasm Proteins', 'Neuroendocrine Tumors', 'Peptides', 'Pheochromocytoma', 'Predictive Value of Tests... | 24,523,932 | [['C04.588.322.078', 'C19.053.347', 'C19.344.078'], ['M01.060.116'], ['M01.060.116.100'], ['D23.101'], ['A06.224.161', 'A11.299'], ['D12.776.631.199.249'], ['G05.308.370'], ['M01.774.500', 'M01.955.236'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['G05.365.590'], ['D12.776.624'], ['C04.557.4... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Efficient removal of endosulfan from aqueous solution by UV-C/peroxides: a comparative study. | This study explored the efficiency of UV-C-based advanced oxidation processes (AOPs), i.e., UV/S2O8(2-), UV/HSO5(-), and UV/H2O2 for the degradation of endosulfan, an organochlorine insecticide and an emerging water pollutant. A significant removal, 91%, 86%, and 64%, of endosulfan, at an initial concentration of 2.45 ... | ['Alcohols', 'Anions', 'Dose-Response Relationship, Drug', 'Dose-Response Relationship, Radiation', 'Endosulfan', 'Free Radical Scavengers', 'Gas Chromatography-Mass Spectrometry', 'Hydrogen Peroxide', 'Hydroxyl Radical', 'Kinetics', 'Models, Chemical', 'Organic Chemicals', 'Oxygen', 'Peroxides', 'Pesticides', 'Photoly... | 24,231,332 | [['D02.033'], ['D01.248.497.158'], ['G07.690.773.875', 'G07.690.936.500'], ['E05.799.513.500', 'G01.750.740.500', 'G04.712.500', 'G07.225', 'G07.738.500', 'N06.850.810.250.180'], ['D02.886.092.408', 'D03.633.100.197.408'], ['D27.505.519.217.500'], ['E05.196.181.349.500', 'E05.196.566.500'], ['D01.248.497.158.685.750.42... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[Experimental study on the splenic factor influencing hepatic regeneration]. | The splenic factor influencing hepatic regeneration was investigated by using primary cultures of adult rat hepatocytes. The uptake of 3H-thymidine into DNA (DNA synthesis) of primary cultured hepatocytes reached maximum at 48 hours after initiation of incubation both in a splenic-extract added group and in a control-s... | ['Animals', 'Cells, Cultured', 'Chromatography, Gel', 'DNA', 'Liver', 'Liver Regeneration', 'Male', 'Molecular Weight', 'Rats', 'Rats, Inbred Strains', 'Spleen', 'Thymidine', 'Tissue Extracts'] | 3,807,879 | [['B01.050'], ['A11.251'], ['E05.196.181.400.250'], ['D13.444.308'], ['A03.620'], ['G10.261.475', 'G16.762.468'], ['G02.494'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760', 'B01.050.150.900.649.313.992.635.505.700.400'], ['A10.549.700', 'A15.382.520.604.700'], ['D03.383.742.680.705', 'D13.570... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Northern Spotted Owl (Strix occidentalis caurina) Genome: Divergence with the Barred Owl (Strix varia) and Characterization of Light-Associated Genes. | We report here the assembly of a northern spotted owl (Strix occidentalis caurina) genome. We generated Illumina paired-end sequence data at 90? coverage using nine libraries with insert lengths ranging from ?250 to 9,600 nt and read lengths from 100 to 375 nt. The genome assembly is comprised of 8,108 scaffolds totali... | ['Animals', 'Birds', 'Genome', 'Genome, Mitochondrial', 'Light', 'Molecular Sequence Annotation', 'Strigiformes', 'Vision, Ocular'] | 28,992,302 | [['B01.050'], ['B01.050.150.900.248'], ['G05.360.340'], ['G05.360.340.360'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['E05.393.760.479', 'L01.453.245.667.580'], ['B01.050.150.900.248.815.550'], ['F02.830.816.964', 'G02.111.820.480.900', 'G04.835.480.900', 'G11.561.790.964', 'G14.93... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Epigenotoxicity of environmental pollutants evaluated by a combination of DNA methylation inhibition and capillary electrophoresis-laser-induced fluorescence immunoassay. | A variety of environmental pollutants may cause abnormal DNA methylation, which further disturb gene expression. In this work, we developed a rapid and sensitive method for the characterization and identification of the epigenotoxicity of environmental pollutants in terms of DNA methylation. The method combines in vitr... | ['DNA', 'DNA Methylation', 'DNA Modification Methylases', 'Electrophoresis, Capillary', 'Environmental Pollutants', 'Enzyme Inhibitors', 'Immunoassay'] | 23,377,082 | [['D13.444.308'], ['G02.111.035.538.161', 'G02.111.218', 'G03.059.538.161', 'G05.206'], ['D08.811.150.240', 'D08.811.913.555.500.350'], ['E05.196.401.190', 'E05.301.300.190'], ['D27.888.284'], ['D27.505.519.389'], ['E05.478.566', 'E05.601.470']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Methanol metabolism in the Asian corn borer, Ostrinia furnacalis (Guen?e) (Lepidoptera: Pyralidae). | Plants produce and release large quantities of methanol, especially when attacked by herbivores. It seems that the herbivores may suffer from methanol intoxication. Here we reported the tolerance to and the metabolism of methanol by Ostrinia furnacalis third-instar larvae. When larvae were exposed to dietary methanol, ... | ['Alcohol Dehydrogenase', 'Animals', 'Catalase', 'Cytochrome P-450 Enzyme System', 'Insect Proteins', 'Larva', 'Methanol', 'Moths'] | 19,883,652 | [['D08.811.682.047.820.250'], ['B01.050'], ['D08.811.682.732.332'], ['D08.244.453', 'D08.811.682.690.708.170', 'D12.776.422.220.453'], ['D12.776.093.500'], ['B05.500.500', 'G07.345.500.550.500.500'], ['D02.033.623'], ['B01.050.500.131.617.720.500.500.937.650']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of gut-directed hypnotherapy on IBS in different clinical settings-results from two randomized, controlled trials. | OBJECTIVES: Gut-directed hypnotherapy has been found to be effective in irritable bowel syndrome (IBS). However, randomized, controlled studies are rare and few have been performed outside highly specialized research centers. The objective of this study was to study the effect of gut-directed hypnotherapy in IBS in dif... | ['Adult', 'Aged', 'Female', 'Humans', 'Hypnosis', 'Irritable Bowel Syndrome', 'Male', 'Middle Aged', 'Quality of Life', 'Surveys and Questionnaires', 'Treatment Outcome'] | 21,971,535 | [['M01.060.116'], ['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.190.525.217', 'F04.754.424'], ['C06.405.469.158.272.608'], ['M01.060.116.630'], ['I01.800', 'K01.752.400.750', 'N06.850.505.400.425.837'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980'], ['E01.789.800', 'N04... | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Stability and succession of the rhizosphere microbiota depends upon plant type and soil composition. | We examined succession of the rhizosphere microbiota of three model plants (Arabidopsis, Medicago and Brachypodium) in compost and sand and three crops (Brassica, Pisum and Triticum) in compost alone. We used serial inoculation of 24 independent replicate microcosms over three plant generations for each plant/soil comb... | ['Arabidopsis', 'Bacteria', 'Brachypodium', 'Brassica', 'Crops, Agricultural', 'Fungi', 'Hydrogen-Ion Concentration', 'Medicago', 'Microbiota', 'Peas', 'Plant Development', 'RNA, Ribosomal, 16S', 'Rhizosphere', 'Soil', 'Soil Microbiology', 'Triticum'] | 25,909,975 | [['B01.650.940.800.575.912.250.157.100'], ['B03'], ['B01.650.940.800.575.912.250.822.072'], ['B01.650.940.800.575.912.250.157.200'], ['B01.650.160', 'G07.203.300.300', 'J02.500.300'], ['B01.300'], ['G02.300'], ['B01.650.940.800.575.912.250.401.590'], ['G06.591', 'G16.500.275.157.049.100.500', 'N06.230.124.049.100.500']... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 |
Cholecystectomy and abdominal hysterectomy. | Cholelithiasis is a common disease in women and can lead to serious complications. At Wilford Hall USAF Medical Center, we have performed 21 cholecystectomies at the time of abdominal hysterectomy. All patients had been asymptomatic with regard to gallbladder disease, but showed either preoperative or intraoperative ev... | ['Adult', 'Aged', 'Cholecystectomy', 'Cholecystitis', 'Cholelithiasis', 'Diagnostic Techniques, Surgical', 'Female', 'Genital Diseases, Female', 'Humans', 'Hysterectomy', 'Middle Aged', 'Risk'] | 7,431,553 | [['M01.060.116'], ['M01.060.116.100'], ['E04.210.120.172'], ['C06.130.564.263'], ['C06.130.409'], ['E01.370.388'], ['C13.351.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.950.300.399'], ['M01.060.116.630'], ['E05.318.740.600.800', 'G17.680.750', 'N05.715.360.750.625.700', 'N06.850.520.830.600.800']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Transition states. Trapping a transition state in a computationally designed protein bottle. | The fleeting lifetimes of the transition states (TSs) of chemical reactions make determination of their three-dimensional structures by diffraction methods a challenge. Here, we used packing interactions within the core of a protein to stabilize the planar TS conformation for rotation around the central carbon-carbon b... | ['Alanine', 'Archaeal Proteins', 'Biphenyl Compounds', 'Computer Simulation', 'Computer-Aided Design', 'Crystallography, X-Ray', 'Entropy', 'Models, Chemical', 'Protein Structure, Secondary', 'Pyrococcus abyssi', 'Software', 'Threonine-tRNA Ligase'] | 25,700,516 | [['D12.125.042'], ['D12.776.090'], ['D02.455.426.559.389.185'], ['L01.224.160'], ['L01.224.108.150', 'L01.296.110.150'], ['E05.196.309.742.225'], ['G01.906.345'], ['E05.599.495'], ['G02.111.570.820.709.600'], ['B02.200.825.800.650.020'], ['L01.224.900'], ['D08.811.464.263.200.800']] | ['Chemicals and Drugs [D]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Perturbations alter community convergence, divergence, and formation of multiple community states. | Environmental perturbations (e.g., disturbance, fertilization) commonly shift communities to a new mean state, but much less is known about their effects on the variability (dispersion) of communities around the mean, particularly when perturbations are combined. Community dispersion may increase or decrease (represent... | ['Biological Evolution', 'Biomass', 'Conservation of Natural Resources', 'Demography', 'Ecosystem', 'Fertilizers', 'Models, Biological', 'Plant Development', 'Poaceae', 'Random Allocation', 'Rosaceae', 'Soil'] | 18,724,727 | [['G05.045', 'G16.075'], ['G16.500.275.157.100', 'N06.230.124.100'], ['J01.256', 'N06.230.080'], ['I01.240', 'N01.224', 'N06.850.505.400'], ['G16.500.275.157', 'N06.230.124'], ['D27.720.031.400'], ['E05.599.395'], ['G07.345.625', 'G15.589'], ['B01.650.940.800.575.912.250.822'], ['E05.318.370.700', 'E05.581.500.805', 'N... | ['Phenomena and Processes [G]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 |
Cell-mediated immunity to hepatitis B virus antigens in mice: correlation of in vivo and in vitro assays. | Cell mediated immunity (CMI) to hepatitis B viral antigens was studied in BALB/mice after immunization with purified hepatitis B surface antigen (HBsAg), or core antigen (HBcAg), with adjuvants. The two in vitro assays for cell-mediated immunity (CMI), utilizing lymph node cells, were release of interferon after exposu... | ['Adjuvants, Immunologic', 'Animals', 'Female', 'Hepatitis B', 'Hepatitis B Antigens', 'Hepatitis B Core Antigens', 'Hepatitis B Surface Antigens', 'Hypersensitivity, Delayed', 'Immunity, Cellular', 'Immunization, Passive', 'Interferon-gamma', 'Lymphocyte Activation', 'Mice', 'Mice, Inbred BALB C'] | 3,091,300 | [['D27.505.696.477.067'], ['B01.050'], ['C01.221.250.500', 'C01.925.256.430.400', 'C01.925.440.435', 'C06.552.380.705.437'], ['D23.050.327.495.500'], ['D23.050.327.495.500.450'], ['D23.050.327.495.500.475'], ['C20.543.418'], ['G12.450.050.400'], ['E02.095.465.425.400.330', 'E05.478.550.520'], ['D12.644.276.374.440.893'... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Systematic Comparison of Bacterial Colonization of Endometrial Tissue and Fluid Samples in Recurrent Miscarriage Patients: Implications for Future Endometrial Microbiome Studies. | BACKGROUND: A recent study has reported that the microbiota in endometrial fluid of patients receiving in vitro fertilization and embryo transfer (IVF-ET) may predict implantation and pregnancy rates. However, studies are lacking that simultaneously compare the microbiota between endometrial fluid and tissue samples. W... | ['Abortion, Habitual', 'Adult', 'Bacteria', 'Body Fluids', 'Endometrium', 'Female', 'Fertilization in Vitro', 'High-Throughput Nucleotide Sequencing', 'Humans', 'Microbiota', 'RNA, Ribosomal, 16S'] | 30,237,148 | [['C13.703.039.089'], ['M01.060.116'], ['B03'], ['A12.207'], ['A05.360.319.679.490'], ['E02.875.800.750', 'E05.820.800.750'], ['E05.393.760.319'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G06.591', 'G16.500.275.157.049.100.500', 'N06.230.124.049.100.500'], ['D13.444.735.686.670']] | ['Diseases [C]', 'Named Groups [M]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Recurrent Granulibacter bethesdensis infections and chronic granulomatous disease. | Chronic granulomatous disease (CGD) is characterized by frequent infections, most of which are curable. Granulibacter bethesdensis is an emerging pathogen in patients with CGD that causes fever and necrotizing lymphadenitis. However, unlike typical CGD organisms, this organism can cause relapse after clinical quiescenc... | ['Acetobacteraceae', 'Adolescent', 'Adult', 'Base Sequence', 'Communicable Diseases, Emerging', 'DNA Primers', 'Genome, Bacterial', 'Genomic Instability', 'Gram-Negative Bacterial Infections', 'Granulomatous Disease, Chronic', 'Humans', 'Male', 'RNA, Bacterial', 'RNA, Ribosomal, 16S', 'Recurrence'] | 20,735,916 | [['B03.440.400.425.100', 'B03.660.050.755.050'], ['M01.060.057'], ['M01.060.116'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['C01.221.500', 'C23.550.291.531.750'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['G05.360.340.358.207'], ['C23.550.362', 'G05.365.590.335', 'G05.370'], ['C01.... | ['Organisms [B]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Bladder augmentation with an omental pedicled gastric seromuscular flap without the necessity of gastric resection. | Bladder augmentation using gastrointestinal segments requires gastric or intestinal resection. This has several risks. In a rat model, we aimed to test the efficacy of a new procedure in which a gastric seromuscular (GSM) flap is separated from the gastric mucosa without the necessity of gastric resection, and this GSM... | ['Animals', 'Biopsy, Needle', 'Disease Models, Animal', 'Female', 'Gastric Mucosa', 'Immunohistochemistry', 'Omentum', 'Probability', 'Rats', 'Rats, Inbred Strains', 'Reconstructive Surgical Procedures', 'Risk Assessment', 'Sensitivity and Specificity', 'Surgical Flaps', 'Survival Rate', 'Treatment Outcome', 'Urinary B... | 15,103,430 | [['B01.050'], ['E01.370.225.500.384.100.119', 'E01.370.225.998.054.119', 'E01.370.388.100.100', 'E04.074.119', 'E04.665.100', 'E05.200.500.384.100.119', 'E05.200.998.054.119', 'E05.242.384.100.119'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['A03.556.875.875.440', 'A10.615.550.291'], ['E01.370.225.500.607.512', '... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Serum microRNA-21 predicted treatment outcome and survival in HER2-positive breast cancer patients receiving neoadjuvant chemotherapy combined with trastuzumab. | PURPOSE: The purpose of this study was to evaluate the expression of ser-miRNAs at different periods during treatment and analyze their relationship with therapeutic response and prognosis in HER2-positive breast cancer patients receiving neoadjuvant chemotherapy combined with trastuzumab (NCCT).METHODS: Venous blood w... | ['Adult', 'Aged', 'Antineoplastic Agents, Immunological', 'Breast Neoplasms', 'Disease-Free Survival', 'Female', 'Humans', 'MicroRNAs', 'Middle Aged', 'Neoadjuvant Therapy', 'Prognosis', 'Receptor, ErbB-2', 'Survival Rate', 'Trastuzumab', 'Treatment Outcome'] | 31,482,230 | [['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.248.384'], ['C04.588.180', 'C17.800.090.500'], ['E01.789.800.190', 'E05.318.740.998.300', 'N04.761.559.590.800.190', 'N05.715.360.575.575.800.190', 'N05.715.360.750.795.300', 'N06.850.520.830.998.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D13.150.650.3... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
trans-acting mutations in loci other than kdpDE that affect kdp operon regulation in Escherichia coli: effects of cytoplasmic thiol oxidation status and nucleoid protein H-NS on kdp expression. | Transcription of the K(+) transport operon kdp in Escherichia coli is induced during K(+)-limited growth by the action of a dual-component phosphorelay regulatory system comprised of a sensor kinase (integral membrane protein), KdpD, and a DNA-binding response regulator (cytoplasmic protein), KdpE. In this study, we sc... | ['Bacterial Proteins', 'Cytoplasm', 'DNA-Binding Proteins', 'Escherichia coli', 'Escherichia coli Proteins', 'Gene Expression Regulation, Bacterial', 'Ion Transport', 'Mutation', 'Operon', 'Oxidation-Reduction', 'Potassium', 'Protein Kinases', 'Sulfhydryl Compounds', 'Thioredoxin-Disulfide Reductase', 'Thioredoxins', '... | 11,114,904 | [['D12.776.097'], ['A11.284.430.214'], ['D12.776.260'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D12.776.097.275'], ['G05.308.300'], ['G03.143.500'], ['G05.365.590'], ['G05.360.340.024.686', 'G05.360.340.358.207.500'], ['G02.700', 'G03.295.531'], ['D01.268.549.550', 'D01.268.557.575', 'D01.552.528.652'... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Improvement of cisplatin-related renal dysfunction by synthetic ghrelin: a prospective randomised phase II trial. | BACKGROUND: Ghrelin, a 28-amino acid peptide predominantly produced by the stomach, exerts powerful renal protective effects by increasing levels of insulin-like growth factor-1 (IGF-1). The aim of this study was to evaluate the effects of ghrelin on the incidence of renal dysfunction in patients receiving cisplatin-ba... | ['Aged', 'Antineoplastic Combined Chemotherapy Protocols', 'Carcinoma, Squamous Cell', 'Cisplatin', 'Creatinine', 'Drug Interactions', 'Esophageal Neoplasms', 'Esophageal Squamous Cell Carcinoma', 'Female', 'Ghrelin', 'Humans', 'Insulin-Like Growth Factor I', 'Kidney', 'Kidney Diseases', 'Male', 'Prospective Studies'] | 27,253,174 | [['M01.060.116.100'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['D01.210.375', 'D01.625.125', 'D01.710.100'], ['D03.383.129.308.207'], ['G07.690.773.968'], ['C04.588.274.476.205', 'C04.588.443.353', 'C06.301.371.205', 'C06.405.117.430', 'C06.405.249.205'... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Measuring the projected public health impact of lung cancer through lifetime and age-conditional risk estimates. | PURPOSE: Lifetime and age-conditional probability (risk) estimates of developing lung cancer in the United States are presented by age, race, and gender. Effects on the risk estimates of an aging population and changing tobacco use are identified.METHODS: Risk estimates were derived by applying cross-sectional, populat... | ['Adult', 'Age Distribution', 'Age of Onset', 'Aged', 'Cohort Studies', 'Continental Population Groups', 'Cross-Sectional Studies', 'Female', 'Humans', 'Incidence', 'Life Tables', 'Lung Neoplasms', 'Male', 'Middle Aged', 'Probability', 'Risk Assessment', 'Sex Factors', 'Smoking'] | 10,691,062 | [['M01.060.116'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['N05.715.350.075.100', 'N06.850.490.250.100'], ['M01.060.116.100'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['M01.686.508'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Development and validation of a liquid chromatography/mass spectrometry method for pharmacokinetic studies of OZ78, a fasciocidal drug candidate. | Fascioliasis is a zoonotic disease of considerable public health and great veterinary significance and new drugs are needed. OZ78 is a promising fasciocidal drug candidate. In order to support the development of OZ78, including pharmacokinetic (PK) studies an accurate, precise, and selective liquid chromatography/mass ... | ['Adamantane', 'Animals', 'Antiplatyhelmintic Agents', 'Chromatography, Liquid', 'Drug Stability', 'Fascioliasis', 'Mass Spectrometry', 'Reproducibility of Results', 'Sensitivity and Specificity', 'Sheep'] | 20,829,125 | [['D02.455.426.100.050', 'D02.455.426.392.368.075'], ['B01.050'], ['D27.505.954.122.250.075.100'], ['E05.196.181.400'], ['E05.916.330'], ['C01.610.335.865.354', 'C01.610.518.424', 'C06.552.664.424'], ['E05.196.566'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['E05.318.370.800', '... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
The release of hydrogen reaction of graphene modified NaAlH4. | In this experiment, we prepared a better performance graphene, by using butyrolactone and flavanone, promoting the graphite into high quality graphene strip. The obtained graphene were used to catalyze the hydrogen released by NaAlH4. The result proved that 5 wt% doped butyrolactone treated graphite and 2 wt% doped fla... | ['4-Butyrolactone', 'Aluminum Compounds', 'Flavanones', 'Graphite', 'Hydrogen', 'Sodium Compounds'] | 22,413,337 | [['D02.540.150', 'D03.383.312.150'], ['D01.056'], ['D03.383.663.283.266.450.252', 'D03.633.100.150.266.450.252'], ['D01.268.150.300', 'D01.578.300'], ['D01.268.406', 'D01.362.340'], ['D01.857']] | ['Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cerebral proton magnetic resonance spectroscopy of a patient with giant axonal neuropathy. | Magnetic resonance imaging of a girl with giant axonal neuropathy revealed a progressive white matter disease. In close agreement with histopathological features reported previously, localized proton magnetic resonance spectroscopy at 9 and 12 years of age indicated a specific damage or loss of axons (reduced N-acetyla... | ['Axons', 'Brain', 'Child', 'Cytoskeletal Proteins', 'Demyelinating Diseases', 'Disease Progression', 'Female', 'Humans', 'Infant', 'Magnetic Resonance Spectroscopy', 'Metabolism, Inborn Errors', 'Mutation'] | 12,536,033 | [['A08.675.542.145', 'A11.284.180.075', 'A11.671.137', 'A11.671.501.145'], ['A08.186.211'], ['M01.060.406'], ['D12.776.220'], ['C10.314'], ['C23.550.291.656'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['E05.196.867.519'], ['C16.320.565', 'C18.452.648'], ['G05.365.590']] | ['Anatomy [A]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Molecular determinants of cetuximab efficacy. | PURPOSE: To investigate whether mRNA expression levels of cyclin D1 (CCND1), cyclooxygenase 2 (Cox-2), epidermal growth factor receptor (EGFR), interleukin 8 (IL-8), and vascular endothelial growth factor (VEGF), all members of the EGFR signaling pathway, are associated with clinical outcome in patients with EGFR-expre... | ['Adult', 'Aged', 'Aged, 80 and over', 'Antibodies, Monoclonal', 'Antibodies, Monoclonal, Humanized', 'Cetuximab', 'Colorectal Neoplasms', 'Cyclooxygenase 2', 'ErbB Receptors', 'Female', 'Gene Expression Regulation, Neoplastic', 'Genetic Markers', 'Humans', 'Interleukin-8', 'Male', 'Membrane Proteins', 'Middle Aged', '... | 15,908,664 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D12.776.124.486.485.114.224.060', 'D12.776.124.790.651.114.224.060', 'D12.776.377.715.548.114.224.200'], ['D12.776.124.486.485.114.224.060.750', 'D12.776.124.7... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The influence of behavioural and psychological factors on medication adherence over time in rheumatoid arthritis patients: a study in the biologics era. | OBJECTIVES: To investigate levels of self-reported adherence to biologic treatment and establish the contribution of demographic, physical and psychological factors to biologic medication adherence in an RA cohort.METHODS: Adalimumab-treated patients were recruited through the British Society for Rheumatology Biologics... | ['Adalimumab', 'Adult', 'Arthritis, Rheumatoid', 'Biological Products', 'Culture', 'Female', 'Humans', 'Longitudinal Studies', 'Male', 'Medication Adherence', 'Middle Aged', 'Patient Compliance', 'Retrospective Studies', 'Self Report', 'Severity of Illness Index', 'Social Support', 'Surveys and Questionnaires', 'Time F... | 25,972,390 | [['D12.776.124.486.485.114.224.060.250', 'D12.776.124.790.651.114.224.060.250', 'D12.776.377.715.548.114.224.200.250'], ['M01.060.116'], ['C05.550.114.154', 'C05.799.114', 'C17.300.775.099', 'C20.111.199'], ['D20.215'], ['I01.076.201.450', 'I01.880.853.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.3... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Is geomagnetic activity a risk factor for sudden unexplained death in epilepsies? | OBJECTIVE: To test the hypothesis that sudden unexplained death (SUD) in epilepsy is related to geomagnetic activity.BACKGROUND: Prior studies presume that geomagnetic activity (with average amplitudes above 50 nanotesla [nT]) is associated with SUD in epileptic human patients and in epileptic laboratory rats.METHODS: ... | ['Adult', 'Death, Sudden', 'Earth, Planet', 'Electromagnetic Fields', 'Epilepsy', 'Female', 'Humans', 'Male', 'Middle Aged', 'Risk Factors', 'Time Factors'] | 10,690,984 | [['M01.060.116'], ['C23.550.260.322'], ['G01.060.075.730.700.200'], ['G01.358.500.260', 'G01.358.750.500'], ['C10.228.140.490'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.740.600.800.725', 'N05.715.350.200.700', 'N05.715.360.750.625.700.700', 'N06.850.490.625.750', 'N06.850.520.830... | ['Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
CD36 mediates long-chain fatty acid transport in human myocardium: complete myocardial accumulation defect of radiolabeled long-chain fatty acid analog in subjects with CD36 deficiency. | Long-chain fatty acids (LCFA) are the major energy substrate for heart and their oxidation is important for achieving maximal cardiac work. However, the mechanism of uptake of LCFA by myocardium has not been clarified. We previously reported that bovine myocardial LCFA transporter has a sequence homology to human CD36.... | ['Aged', 'CD36 Antigens', 'Carrier Proteins', 'Fatty Acids', 'Female', 'Flow Cytometry', 'Heart', 'Humans', 'Male', 'Middle Aged', 'Mutation', 'Myocardium', 'Radionuclide Imaging'] | 10,331,667 | [['M01.060.116.100'], ['D12.776.157.530.300.500', 'D12.776.395.550.625.136', 'D12.776.543.550.625.136', 'D12.776.543.585.300.500', 'D12.776.543.750.011', 'D12.776.543.750.705.675.136', 'D12.776.543.750.705.940.625.249', 'D12.776.543.750.710.450.750.625.249'], ['D12.776.157'], ['D10.251'], ['E01.370.225.500.363.342', 'E... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Cigarette smoking is negatively associated with keratoconus. | PURPOSE: To investigate a correlation between cigarette smoking and keratoconus.METHODS: Patients with keratoconus who were treated with corneal collagen cross-linking from June 2006 to November 2007 were asked about their smoking habits. A person smoking a minimum of two cigarettes per day for more than 1 year was cla... | ['Adolescent', 'Adult', 'Collagen', 'Corneal Stroma', 'Disease Progression', 'Female', 'Humans', 'Keratoconus', 'Male', 'Photochemotherapy', 'Photosensitizing Agents', 'Riboflavin', 'Smoking', 'Surveys and Questionnaires', 'Ultraviolet Rays'] | 18,811,121 | [['M01.060.057'], ['M01.060.116'], ['D05.750.078.280', 'D12.776.860.300.250'], ['A09.371.060.217.228'], ['C23.550.291.656'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C11.204.627'], ['E02.186.500', 'E02.319.685', 'E02.774.722'], ['D27.505.954.444.600', 'D27.505.954.600.710'], ['D03.633.100.733.315.650', 'D03.6... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Anticipatory Behavior in Response to Medicare Part D's Coverage Gap. | Under the standard Medicare Part D benefit structure, copayments for medications change discontinuously at certain levels of accumulative drug spending. Beneficiaries pay 25% of the cost of medications in the initial phase, 100% in the coverage gap, and 5% in the catastrophic phase. We examine whether individuals antic... | ['Aged', 'Choice Behavior', 'Cost Sharing', 'Drug Utilization', 'Female', 'Humans', 'Insurance Coverage', 'Insurance, Health', 'Male', 'Medicare Part D', 'Medication Adherence', 'Poverty', 'Prescription Drugs', 'United States'] | 26,749,399 | [['M01.060.116.100'], ['F02.463.785.373.346'], ['N03.219.151.170', 'N03.219.521.576.090'], ['N04.452.706.477'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.219.521.576.265'], ['N03.219.521.576.343'], ['N03.219.521.576.343.575.500', 'N03.219.521.576.343.840.938', 'N03.706.615.752'], ['F01.100.150.750.500.600.... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Chemicals and Drugs [D]', 'Geographicals [Z]'] | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Direct exchange of vitamin B12 is demonstrated by modelling the growth dynamics of algal-bacterial cocultures. | The growth dynamics of populations of interacting species in the aquatic environment is of great importance, both for understanding natural ecosystems and in efforts to cultivate these organisms for industrial purposes. Here we consider a simple two-species system wherein the bacterium Mesorhizobium loti supplies vitam... | ['Chlorophyta', 'Coculture Techniques', 'Ecosystem', 'Fresh Water', 'Mesorhizobium', 'Models, Statistical', 'Symbiosis', 'Vitamin B 12'] | 24,522,262 | [['B01.650.940.150'], ['E05.481.500.374'], ['G16.500.275.157', 'N06.230.124'], ['G16.500.275.280', 'N06.230.232'], ['B03.660.050.600.500'], ['E05.318.740.500', 'E05.599.835', 'N05.715.360.750.530', 'N06.850.520.830.500'], ['G06.550.800', 'G16.840'], ['D03.383.129.578.840.437.777', 'D03.633.400.909.437.777', 'D04.345.78... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Staged partitioning of single ventricle. | Five patients between the ages of 3 and 10 months underwent a two-stage septation for common ventricle. The first stage involved the placement of a small patch in the apex and a second patch between the atrioventricular and semilunar valves. A center section was left open, as if there were ventricular septal defect. A ... | ['Heart Septal Defects, Ventricular', 'Heart Valves', 'Heart Ventricles', 'Humans', 'Infant', 'Polytetrafluoroethylene', 'Postoperative Complications', 'Pulmonary Artery'] | 6,503,319 | [['C14.240.400.560.540', 'C14.280.400.560.540', 'C16.131.240.400.560.540'], ['A07.541.510'], ['A07.541.560'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['D05.750.395.616', 'D25.720.395.616', 'J01.637.051.720.395.616'], ['C23.550.767'], ['A07.015.114.715']] | ['Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 |
Adhesion of Streptococcus mitis and Actinomyces oris in co-culture to machined and anodized titanium surfaces as affected by atmosphere and pH. | BACKGROUND: With the rising demand for osseointegrated titanium implants for replacing missing teeth, often in patients with a history of periodontitis, implant-related infections have become an issue of growing concern. Novel methods for treating and preventing implant-associated infections are urgently needed. The ai... | ['Actinomyces', 'Aerobiosis', 'Anaerobiosis', 'Bacterial Adhesion', 'Colony Count, Microbial', 'Dental Implants', 'Hydrogen-Ion Concentration', 'Microscopy, Confocal', 'Streptococcus mitis', 'Surface Properties', 'Titanium'] | 23,298,213 | [['B03.510.024.049.050.050', 'B03.510.460.400.400.049.049.178'], ['G02.111.017', 'G03.049'], ['G02.111.062', 'G03.078'], ['G06.099.050'], ['E01.370.225.875.220', 'E05.200.875.220'], ['D25.339.312', 'E06.780.346.593', 'E07.695.185', 'J01.637.051.339.312'], ['G02.300'], ['E01.370.350.515.395', 'E05.595.395'], ['B03.353.7... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Notch3 is necessary for neuronal differentiation and maturation in the adult spinal cord. | Notch receptors are key regulators of nervous system development and promoters of neural stem cells renewal and proliferation. Defects in the expression of Notch genes result in severe, often lethal developmental abnormalities. Notch3 is generally thought to have a similar proliferative, anti-differentiation and glioge... | ['Adult', 'Animals', 'Behavior, Animal', 'Blotting, Western', 'Cell Differentiation', 'Cells, Cultured', 'Fluorescent Antibody Technique', 'Gene Expression Regulation, Developmental', 'Humans', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Mice, Knockout', 'Neural Stem Cells', 'Neurons', 'Rats', 'Rats, Sprague-Dawley', 'Recep... | 25,164,209 | [['M01.060.116'], ['B01.050'], ['F01.145.113'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['G04.152'], ['A11.251'], ['E01.370.225.500.607.512.240', 'E01.370.225.750.551.512.240', 'E05.200.500.607.512.240', 'E05.200.750.551.512.240', 'E05.478.583.375'], ['G05.30... | ['Named Groups [M]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Excluded volume in solvation: sensitivity of scaled-particle theory to solvent size and density. | Changes in solvent environment greatly affect macromolecular structure and stability. To investigate the role of excluded volume in solvation, scaled-particle theory is often used to calculate delta G(tr)(ev), the excluded-volume portion of the solute transfer free energy, delta G(tr). The inputs to SPT are the solvent... | ['Biophysical Phenomena', 'Biophysics', 'Ethanol', 'Ethylene Glycol', 'Macromolecular Substances', 'Models, Chemical', 'Solvents', 'Sucrose', 'Thermodynamics', 'Urea'] | 11,053,104 | [['G01.154'], ['H01.158.344', 'H01.671.100'], ['D02.033.375'], ['D02.033.455.250.268'], ['D05'], ['E05.599.495'], ['D27.720.844'], ['D09.698.629.305.770', 'D09.947.750.770'], ['G01.906'], ['D02.065.950']] | ['Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Integration of filgrastim into chemoradiation for limited small cell lung cancer: a Phase I study. | PURPOSE: Recent studies document the value of early combined modality therapy of small cell lung cancer, but also indicate that early thoracic radiation adds to myelosuppression and can complicate further chemotherapy. Other studies indicate that simultaneous use of growth factors with thoracic radiation may be deleter... | ['Adult', 'Aged', 'Antineoplastic Combined Chemotherapy Protocols', 'Carcinoma, Small Cell', 'Cisplatin', 'Cohort Studies', 'Combined Modality Therapy', 'Disease-Free Survival', 'Etoposide', 'Female', 'Fever', 'Filgrastim', 'Granulocyte Colony-Stimulating Factor', 'Humans', 'Ifosfamide', 'Lung Neoplasms', 'Male', 'Midd... | 9,457,817 | [['M01.060.116'], ['M01.060.116.100'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['C04.557.470.200.380'], ['D01.210.375', 'D01.625.125', 'D01.710.100'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E02.186'], ['E01.789.800.190', 'E05.318.740.998.300', 'N04.761.559.59... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Aroma-active components of Lycii fructus (kukija). | The fruit of Lycii fructus has been used as a tonic medicine and a long-term healthy food without side effect in Asia. An increase in the demand for natural healthy food, L. fructus has been thought as a source of healthy foods. For its value adding, its character impact aromas were isolated by using direct solvent ext... | ['Aldehydes', 'Butyrates', 'Drugs, Chinese Herbal', 'Fruit', 'Gas Chromatography-Mass Spectrometry', 'Humans', 'Lycium', 'Odorants', 'Plant Extracts', 'Smell', 'Volatilization'] | 19,241,541 | [['D02.047'], ['D02.241.081.114', 'D10.251.400.143'], ['D20.215.784.500.350', 'D26.335'], ['A18.024.500', 'G07.203.300.562', 'J02.500.562'], ['E05.196.181.349.500', 'E05.196.566.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.650.940.800.575.912.250.908.500.310'], ['G16.500.275.640', 'N06.230.480'], ['D20... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Caregiver experience in mental illness: a perspective from a rural community in South Africa. | After the democratization of South Africa in 1994, the health-care system was reorganized in accordance with the primary health-care philosophy advocated by the World Health Organization. This was accompanied by a process of deinstitutionalization of mental health-care services, which has led families to become the mai... | ['Adaptation, Psychological', 'Adult', 'Aged', 'Attitude to Health', 'Caregivers', 'Cost of Illness', 'Deinstitutionalization', 'Family', 'Female', 'Health Services Needs and Demand', 'Humans', 'Male', 'Medication Adherence', 'Mental Disorders', 'Middle Aged', 'Nursing Methodology Research', 'Qualitative Research', 'Ru... | 19,740,145 | [['F01.058'], ['M01.060.116'], ['M01.060.116.100'], ['F01.100.150', 'N05.300.150'], ['M01.085', 'M01.526.485.200', 'N02.360.200'], ['N03.219.151.165', 'N05.715.360.300.800.438.375.182', 'N06.850.520.308.980.438.475.046'], ['E02.760.415.280', 'N02.421.585.415.280'], ['F01.829.263', 'I01.880.853.150'], ['N03.349.380.420'... | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Childhood pulmonary Langerhans cell histiocytosis: a comprehensive clinical-histopathological and BRAFV600E | Childhood pulmonary Langerhans cell histiocytosis (PLCH) is a rare disease. Its pulmonary histopathology, according to comprehensive clinical-radiological findings and BRAFV600E mutation status, has not yet been thoroughly documented. From the 167 childhood PLCH cases entered in the French National Histiocytosis Regist... | ['Adolescent', 'Child', 'Child, Preschool', 'Cohort Studies', 'Female', 'France', 'Histiocytosis, Langerhans-Cell', 'Humans', 'Infant', 'Infant, Newborn', 'Lung Diseases', 'Male', 'Mutation', 'Proto-Oncogene Proteins B-raf', 'Retrospective Studies'] | 31,054,893 | [['M01.060.057'], ['M01.060.406'], ['M01.060.406.448'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['Z01.542.286'], ['C08.381.483.375', 'C15.604.250.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['C08.381'], ['G05.365.590'], ['D08.811.9... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Allergy to limpet. | Allergy to mollusk has rarely been described. The limpet, belonging to Phylum mollusca, is one of the most frequent mollusks in the Canary Islands, as in all warm maritime regions. We report two cases of atopic patients who developed anaphylactic reactions after ingestion of this mollusk. Type I hypersensitivity to lim... | ['Adult', 'Anaphylaxis', 'Animals', 'Female', 'Food Hypersensitivity', 'Humans', 'Hypersensitivity, Immediate', 'Immunoglobulin E', 'Male', 'Mollusca', 'Shellfish', 'Spain'] | 1,796,776 | [['M01.060.116'], ['C20.543.480.099'], ['B01.050'], ['C20.543.480.370'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C20.543.480'], ['D12.776.124.486.485.114.619.312', 'D12.776.124.790.651.114.619.312', 'D12.776.377.715.548.114.619.312'], ['B01.050.500.644'], ['G07.203.300.600.875.700', 'J02.500.600.875.700'], [... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 |
Simplification of rat intubation on inclined metal plate. | Small-animal intubation is often necessary during inhalation anesthesia to allow steady-state conditions for large operations and in vivo experiments in all fields of experimental surgery. In rats, placing an orotracheal tube is technically difficult primarily because of the small size of the subject and the lack of eq... | ['Anesthetics, Inhalation', 'Animals', 'Ether', 'Intubation, Intratracheal', 'Otoscopes', 'Physiology', 'Posture', 'Rats'] | 14,973,009 | [['D27.505.696.277.100.035.060', 'D27.505.954.427.210.100.035.060'], ['B01.050'], ['D02.355.417.332'], ['E02.041.500', 'E02.585.578', 'E05.497.578'], ['E07.230.550'], ['H01.158.782'], ['G11.427.695'], ['B01.050.150.900.649.313.992.635.505.700']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Levels and turnover of the proteinase B inhibitors in yeast. | The ratio of the proteinase B inhibitors IB1 and IB2 from baker's yeast was shown to depend on the yeast strain by specific immunoprecipitation from boiled yeast extract and subsequent electrophoresis of the heat-dissociated precipitates on polyacrylamide gels. Bothe IB1 and IB2 were found, IB2 being by far predominant... | ['Fungal Proteins', 'Hot Temperature', 'Precipitin Tests', 'Protease Inhibitors', 'Saccharomyces', 'Saccharomyces cerevisiae', 'Species Specificity'] | 1,100,120 | [['D12.776.354'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.775.710.380', 'N06.230.300.100.725.232', 'N06.230.300.100.725.710.380'], ['E01.370.225.812.735.645', 'E05.196.150.639.500', 'E05.200.812.735.645', 'E05.478.594.760.645', 'E05.478.605.492'], ['D27.505.519.389.745'], ['B01.300.107.795.785',... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
In vitro studies of liposome-mediated gene transfer into head and neck cancer cell lines. | The 5-year survival rate of patients with squamous cell carcinoma of the head and neck (HNSCC) has remained poor despite innovative surgery and new radiation and chemotherapeutic strategies. In such patients, gene therapy relying on the modification of tumor cells by gene transfer may have great potential as a new trea... | ['Carcinoma', 'Carcinoma, Squamous Cell', 'Cell Line', 'Chloramphenicol O-Acetyltransferase', 'Cytomegalovirus', 'DNA, Viral', 'Enzyme-Linked Immunosorbent Assay', 'Epithelial Cells', 'Epithelium', 'Fatty Acids, Monounsaturated', 'Feasibility Studies', 'Gene Transfer Techniques', 'Genetic Therapy', 'HeLa Cells', 'Head ... | 9,065,647 | [['C04.557.470.200'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['A11.251.210'], ['D08.811.913.050.134.170'], ['B04.280.382.150.150'], ['D13.444.308.568'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['A11.436'], ['A10.272'], ['D10.251.355.3... | ['Diseases [C]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
A history of cardiology in Jamaica. | The history of cardiology in Jamaica is conveniently considered in decades beginning in the 1950s. The decade of the 1950s was characterized by early descriptions of the pattern of cardiac disease in adults and children in Jamaica, the establishment of a cardiac clinic at the University Hospital of the West Indies and ... | ['Cardiac Surgical Procedures', 'Cardiology', 'Cardiology Service, Hospital', 'Cardiovascular Diseases', 'History, 20th Century', 'Hospitals, University', 'Humans', 'Jamaica', 'Surgery Department, Hospital', 'Voluntary Health Agencies'] | 15,352,749 | [['E04.100.376', 'E04.928.220'], ['H02.403.429.163'], ['N02.278.216.500.968.215', 'N04.452.442.452.422.215'], ['C14'], ['K01.400.504.968'], ['N02.278.020.300.310', 'N02.278.421.639.725'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.107.084.900.525', 'Z01.639.880.525'], ['N02.278.216.500.968.750', 'N04.452.44... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Diseases [C]', 'Humanities [K]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
The influence of informal learning and learning transfer on nurses' clinical performance: A descriptive cross-sectional study. | BACKGROUND: Workplace learning in hospitals consists mostly of informal learning processes that take place during specific work situations. Informal learning and effective learning transfer are expected to have a positive impact on nurses' clinical performance.OBJECTIVES: The purpose of this study was to examine the in... | ['Attitude of Health Personnel', 'Clinical Competence', 'Cross-Sectional Studies', 'Humans', 'Nurses', 'Republic of Korea', 'Surveys and Questionnaires', 'Transfer, Psychology', 'Translational Medical Research'] | 31,253,442 | [['F01.100.050', 'N05.300.100'], ['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.526.485.650', 'N02.360.650'], ['Z01.252.474.557.750'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06... | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]', 'Geographicals [Z]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Hyperforin, a bio-active compound of St. John's Wort, is a new inhibitor of angiogenesis targeting several key steps of the process. | Hyperforin, a phloroglucinol derivative found in St. John's wort related mainly to its antidepressant effects, has been reported recently to induce apoptosis in tumour cells and to inhibit cancer invasion and metastasis. We show that hyperforin inhibits angiogenesis in vitro in bovine aortic endothelial cells and in vi... | ['3T3 Cells', 'Angiogenesis Inhibitors', 'Animals', 'Bridged Bicyclo Compounds', 'Cattle', 'Cell Division', 'Cell Line, Tumor', 'Cells, Cultured', 'Endothelium, Vascular', 'Extracellular Matrix', 'Humans', 'Hypericum', 'Mice', 'Neovascularization, Physiologic', 'Phloroglucinol', 'Terpenes'] | 15,981,212 | [['A11.251.210.100', 'A11.329.228.100'], ['D27.505.696.377.077.099', 'D27.505.696.377.450.100', 'D27.505.954.248.025'], ['B01.050'], ['D02.455.426.100.080', 'D04.075.080'], ['B01.050.150.900.649.313.500.380.271'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.251.210.190', 'A11.251.860... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Comprehensive analysis of the L-arginine/L-homoarginine/nitric oxide pathway in preterm neonates: potential roles for homoarginine and asymmetric dimethylarginine in foetal growth. | L-Arginine (Arg) and L-homoarginine (hArg) are precursors of nitric oxide (NO), a signalling molecule with multiple important roles in human organism. In the circulation of adults, high concentrations of asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) and low concentrations of hArg emerged as c... | ['Arginine', 'Female', 'Fetal Development', 'Gestational Age', 'Homoarginine', 'Humans', 'Infant, Newborn', 'Infant, Premature', 'Male', 'Metabolic Networks and Pathways', 'Nitric Oxide'] | 28,161,799 | [['D12.125.068.050', 'D12.125.095.104', 'D12.125.142.087'], ['G07.345.500.325.235', 'G08.686.784.170.157'], ['G07.345.500.325.235.968', 'G08.686.320'], ['D12.125.068.050.400', 'D12.125.095.104.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['M01.060.703.520.520'], ['G03.493'], ['D01.339.38... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Coculture with intraocular lens material-activated macrophages induces an inflammatory phenotype in lens epithelial cells. | Cataracts are the leading cause of blindness worldwide, requiring surgical implantation of an intraocular lens. Despite evidence of leukocyte ingress into the postoperative lens, few studies have investigated the leukocyte response to intraocular lens materials. A novel coculture model was developed to examine macropha... | ['Actins', 'Biocompatible Materials', 'Capsule Opacification', 'Cell Adhesion', 'Cell Line', 'Coculture Techniques', 'Cytokines', 'Epithelial Cells', 'Humans', 'Hydrophobic and Hydrophilic Interactions', 'Inflammation', 'Inflammation Mediators', 'Intercellular Adhesion Molecule-1', 'Lens, Crystalline', 'Lenses, Intraoc... | 25,281,645 | [['D05.750.078.730.250', 'D12.776.210.500.100', 'D12.776.220.525.255'], ['D25.130', 'D27.720.102.130', 'J01.637.051.130'], ['C11.510.245.500'], ['G04.022'], ['A11.251.210'], ['E05.481.500.374'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['A11.436'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.40... | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Development of an immune function assay by measuring intracellular adenosine triphosphate (iATP) levels in mitogen-stimulated CD4+ T lymphocytes. | We developed an immune function assay for monitoring CD4+ T cells activity based on changes in intracellular adenosine triphosphate (iATP) levels after phytohemagglutinin (PHA) stimulation. Blood samples were obtained from 40 healthy subjects and 30 RTRs and incubated with 5 µg/mL of PHA for 15-18 hr at 37°C and 5% CO2... | ['Adenosine Triphosphate', 'Adult', 'CD4-Positive T-Lymphocytes', 'Female', 'Humans', 'Immunity, Cellular', 'Immunoassay', 'Male', 'Middle Aged', 'Phytohemagglutinins', 'Young Adult'] | 27,089,103 | [['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['M01.060.116'], ['A11.118.637.555.567.569.200', 'A15.145.229.637.555.567.569.200', 'A15.382.490.555.567.569.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G12.450.050.400'], ['E05.478.566', 'E05.601.470'], ['M01.060.116.630'], [... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Effects of human neutrophil granule extracts on macromolecular synthesis in Neisseria gonorrhoeae. | Neisseria gonorrhoeae were exponentially killed for 120 min (i.e., they were prevented from forming colonies on agar) by extracts of human neutrophil granules; however, macromolecular synthesis, indicated by incorporation of radiolabeled precursors in trichloroacetic acid-precipitable material, continued at or above ze... | ['Anions', 'Bacterial Proteins', 'Cations', 'Cell Membrane Permeability', 'DNA, Bacterial', 'Humans', 'Kinetics', 'Lysosomes', 'Neisseria gonorrhoeae', 'Neutrophils', 'RNA, Bacterial'] | 6,168,589 | [['D01.248.497.158'], ['D12.776.097'], ['D01.248.497.300'], ['G03.143.335', 'G04.175'], ['D13.444.308.212'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.374.661', 'G02.111.490'], ['A11.284.430.214.190.875.190.550'], ['B03.440.400.425.550.550.474', 'B03.660.075.525.520.400'], ['A11.118.637.415.583', 'A11.627.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Early evidence of molariform hypsodonty in a Triassic stem-mammal. | Hypsodonty, the occurrence of high-crowned teeth, is widespread among mammals with diets rich in abrasive material, such as plants or soil, because it increases the durability of dentitions against wear. Hypsodont postcanine teeth evolved independently in multiple mammalian lineages and in the closely related mammaliaf... | ['Animals', 'Dentition', 'Fossils', 'Mammals', 'Phylogeny', 'Tooth', 'Tooth Wear'] | 31,253,810 | [['B01.050'], ['A03.556.500.379', 'A14.549.167'], ['I01.076.368.584.311'], ['B01.050.150.900.649'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['A14.549.167.860'], ['C07.793.818']] | ['Organisms [B]', 'Anatomy [A]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 |
Defects of the LDL receptor in WHHL transgenic rabbits lead to a marked accumulation of plasma lipoprotein[a]. | In this study, we created LDL receptor (LDLr) defective (WHHL) transgenic rabbits expressing human apo[a] to examine whether LDLr mediates the Lp[a] clearance from the plasma. By crossbreeding WHHL rabbits with human apo[a] transgenic rabbits, we obtained two groups of human apo[a] transgenic rabbits with defective LDL... | ['Animals', 'Animals, Genetically Modified', 'Humans', 'Lipoprotein(a)', 'RNA, Messenger', 'Rabbits', 'Receptors, LDL'] | 10,828,093 | [['B01.050'], ['B01.050.050.136', 'B05.620.136'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D10.532.350', 'D12.776.521.400'], ['D13.444.735.544'], ['B01.050.150.900.649.313.968.700'], ['D12.776.543.750.710.450']] | ['Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Molecular Modelling of Berberine Derivatives as Inhibitors of Human Smoothened Receptor and Hedgehog Signalling Pathway Using a Newly Developed Algorithm on Anti-Cancer Drugs. | BACKGROUND: Protoberberine isoquinoline alkaloids are found in many plant species. They consist of a diverse class of secondary metabolites with many pharmacologically active members, such as different derivatives of berberine already patented. In the development of approximately 20-25% of all cancers, altered hedgehog... | ['Algorithms', 'Antineoplastic Agents', 'Berberine', 'Computer Simulation', 'Hedgehog Proteins', 'Humans', 'Hydrogen Bonding', 'Ligands', 'Models, Molecular', 'Molecular Docking Simulation', 'Neoplasms', 'Patents as Topic', 'RNA, Messenger', 'Signal Transduction', 'Smoothened Receptor', 'Zinc Finger Protein GLI1'] | 28,969,581 | [['G17.035', 'L01.224.050'], ['D27.505.954.248'], ['D03.132.098.057.100', 'D03.633.400.168.100'], ['L01.224.160'], ['D12.644.276.671', 'D12.776.467.671', 'D23.529.671'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.282'], ['D27.720.470.480'], ['E05.599.595'], ['E05.599.595.249', 'L01.224.160.249'], ['C04'], [... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 |
Intensive care unit drug use and subsequent quality of life in acute lung injury patients. | OBJECTIVE: To examine the relationship between the use of sedative and neuromuscular blocking agents during a patient's intensive care unit (ICU) stay and subsequent measures of health-related quality of life.DESIGN: Cross-sectional mail survey and retrospective medical record abstraction of a prospectively identified ... | ['APACHE', 'Adolescent', 'Adult', 'Aged', 'Critical Care', 'Cross-Sectional Studies', 'Female', 'Humans', 'Hypnotics and Sedatives', 'Male', 'Middle Aged', 'Neuromuscular Blocking Agents', 'Quality of Life', 'Respiratory Distress Syndrome', 'Retrospective Studies', 'Severity of Illness Index', 'Stress Disorders, Post-T... | 11,098,964 | [['E05.318.308.980.438.475.365', 'E05.318.308.980.438.475.456.500.250', 'N05.715.360.300.800.438.375.364.500.250', 'N06.850.520.308.980.438.475.364.500.250'], ['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['E02.760.190', 'N02.421.585.190'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.50... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Named Groups [M]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Diseases [C]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Visualizing long-range movement of the morphogen Xnr2 in the Xenopus embryo. | One way in which cells acquire positional information during embryonic development is by measuring the local concentration of a signaling factor, or morphogen, that is secreted by an organizing center . The ways in which morphogen gradients are established, particularly in vertebrates, remain obscure, although various ... | ['Activins', 'Animals', 'Blotting, Western', 'DNA Primers', 'Diffusion', 'Fluorescence', 'Green Fluorescent Proteins', 'In Situ Hybridization', 'Intercellular Signaling Peptides and Proteins', 'Microscopy, Confocal', 'Morphogenesis', 'Reverse Transcriptase Polymerase Chain Reaction', 'Signal Transduction', 'Transformin... | 15,530,392 | [['D06.472.334.500', 'D06.472.699.009', 'D12.644.548.009', 'D12.776.395.022'], ['B01.050'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['G01.202', 'G02.196'], ['G01.358.500.505.650.665.500', 'G01.590.54... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
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