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Altered expression of signalling lymphocyte activation molecule (SLAM) family receptors CS1 (CD319) and 2B4 (CD244) in patients with systemic lupus erythematosus. | CS1 (CRACC, CD319) and 2B4 (CD244), members of the signalling lymphocyte activation molecule (SLAM) family receptors, regulate various immune functions. Genes encoding SLAM family receptors are located at 1q23, implicated in systemic lupus erythematosus (SLE). In this study, we have investigated the expression and alte... | ['Adult', 'Aged', 'Aged, 80 and over', 'Alternative Splicing', 'Antigens, CD', 'Autocrine Communication', 'Case-Control Studies', 'Cell Proliferation', 'Chromosomes, Human, Pair 1', 'Cytokines', 'Female', 'Flow Cytometry', 'Humans', 'Leukocytes, Mononuclear', 'Lupus Erythematosus, Systemic', 'Male', 'Middle Aged', 'Rec... | 20,345,977 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['G02.111.760.700.100', 'G03.839.700.100', 'G05.308.700.700.100'], ['D23.050.301.264.035', 'D23.101.100.110'], ['G04.085.100'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['G04.161.750', 'G07.345.249.410.750'], ['A11.284... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Ectopic Darier's disease of the cervix: an extraordinary cause of an abnormal smear. | A small number of skin diseases may involve either extremity of the alimentary tract or the vulva. Fortunately for patients and cytoscreeners, they rarely involve the cervix or vagina. When they do, difficulty in diagnosis may arise if a full history is not provided. A case is described of cervicovaginal Darier's disea... | ['Cell Nucleus', 'Cervix Uteri', 'Colposcopy', 'Darier Disease', 'Diagnosis, Differential', 'Etretinate', 'Female', 'Humans', 'Middle Aged', 'Skin Diseases', 'Uterine Cervical Diseases', 'Vaginal Smears'] | 8,958,475 | [['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['A05.360.319.679.256'], ['E01.370.378.150', 'E01.370.388.250.150', 'E04.502.250.150', 'E04.520.150', 'E04.950.300.210'], ['C16.320.850.190', 'C17.800.428.275', 'C17.800.827.190'], ['E01.171'], ['D02.455.326.271.665.202.495.250', 'D02.455.849.131.495.250', 'D23.767.2... | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Named Groups [M]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Patterns of gene expression associated with Pten deficiency in the developing inner ear. | In inner ear development, phosphatase and tensin homolog (PTEN) is necessary for neuronal maintenance, such as neuronal survival and accurate nerve innervations of hair cells. We previously reported that Pten conditional knockout (cKO) mice exhibited disorganized fasciculus with neuronal apoptosis in spiral ganglion ne... | ['Animals', 'Ear, Inner', 'Gene Expression Profiling', 'Gene Expression Regulation, Developmental', 'Gene Regulatory Networks', 'Mice, Knockout', 'Oligonucleotide Array Sequence Analysis', 'Osteopontin', 'PTEN Phosphohydrolase', 'RGS Proteins', 'Reproducibility of Results', 'Reverse Transcriptase Polymerase Chain React... | 24,893,171 | [['B01.050'], ['A09.246.300'], ['E05.393.332'], ['G05.308.310'], ['G05.360.080.689.360'], ['B01.050.050.136.500.500', 'B01.050.150.900.649.313.992.635.505.500.550.455', 'B01.050.150.900.649.313.992.635.505.500.800.500'], ['E05.393.661.640', 'E05.393.760.640', 'E05.588.570.660', 'E05.601.640'], ['D12.644.276.374.625', '... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Model of oscillatory activity in thalamic neurons: role of voltage- and calcium-dependent ionic conductances. | This paper describes a computer modeling study of the generation of 10 Hz oscillations in the electrical activity of guinea pig thalamic neurons in vitro. The computer model was based on experimental evidence suggesting that single thalamic neurons in guinea pig have a set of voltage- and calcium-dependent ionic conduc... | ['Action Potentials', 'Animals', 'Calcium', 'Computer Simulation', 'Dendrites', 'Electric Conductivity', 'Guinea Pigs', 'Ion Channels', 'Membrane Potentials', 'Models, Biological', 'Neurons', 'Periodicity', 'Potassium', 'Sodium', 'Thalamus'] | 2,451,936 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['L01.224.160'], ['A08.675.256', 'A11.284.180.225', 'A11.671.240'], ['G01.358.500.249.277'], ['B01.050.150.900.649.313.992.550'], ['D12.776.157.530.400', 'D12.776.543.550.450', 'D12.776.543.585.40... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Information Science [L]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
The effect of semicarbazide on the nature and stability of collagen fibrils. | Semicarbazide affected both the final width and stability of fibrils reconstituted from solutions of acid-soluble collagen. Fibril width was increased after semicarbazide treatment at pH2.6 and 4.3, whereas after treatment at pH8.9 it decreased. Fibril stability was decreased after semicarbazide treatment at all values... | ['Aldehydes', 'Chemical Precipitation', 'Collagen', 'Densitometry', 'Hydrogen-Ion Concentration', 'Macromolecular Substances', 'Protein Binding', 'Semicarbazides', 'Spectrum Analysis', 'Temperature'] | 5,472,156 | [['D02.047'], ['E05.196.150', 'G02.159'], ['D05.750.078.280', 'D12.776.860.300.250'], ['E05.196.712.224'], ['G02.300'], ['D05'], ['G02.111.679', 'G03.808'], ['D02.845'], ['E05.196.867'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.150.450', 'N06.230.300.100.725.710']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
UV irradiation induces downregulation of bcl-2 expression in vitro and in vivo. | Recently, the proto-oncogenes bcl-2 and bax have emerged as important regulators of the apoptotic form of cell death. We examined UV irradiation-elicited apoptosis and regulation of bcl-2 and bax expression both in vivo in human skin and in vitro in HeLa cells. Using flow cytometric analysis, HeLa cells were found to u... | ['Adult', 'Apoptosis', 'DNA Fragmentation', 'Flow Cytometry', 'Gene Expression', 'HeLa Cells', 'Humans', 'Immunohistochemistry', 'Male', 'Proto-Oncogene Proteins', 'Proto-Oncogene Proteins c-bcl-2', 'RNA, Messenger', 'Skin', 'Ultraviolet Rays', 'bcl-2-Associated X Protein'] | 10,335,918 | [['M01.060.116'], ['G04.146.954.035'], ['G05.200.230'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.200.500.386.350', 'E05.242.363.342', 'E05.242.386.350'], ['G05.297'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'], ['B01.050.150.900... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Undiagnosed spinal cord injuries in brain-injured children. | Four children with brain injury were later found to have coexisting spinal cord injury (SCI). Findings that warrant investigation for coexisting SCI include a dermatome pattern sensory loss; absence of movement and reflexes in either both arms or both legs with preservation in the remaining extremities; flaccidity; abs... | ['Brain Injuries', 'Child, Preschool', 'Diagnosis, Differential', 'Female', 'Humans', 'Infant', 'Male', 'Physical Examination', 'Spinal Cord Injuries', 'Wounds and Injuries'] | 3,414,628 | [['C10.228.140.199', 'C10.900.300.087', 'C26.915.300.200'], ['M01.060.406.448'], ['E01.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['E01.370.600'], ['C10.228.854.763', 'C10.900.850', 'C26.819'], ['C26']] | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Comparison of the effectiveness of oral diazepam and midazolam for the sedation of autistic patients during dental treatment. | PURPOSE: This study was undertaken to compare the effectiveness of oral diazepam and midazolam in sedating autistic patients during dental treatment.METHODS: The treatment regimen consisted of nitrous oxide/oxygen inhalation in conjunction with oral administration of either diazepam 0.3 mg/kg or midazolam 0.5 mg/kg in ... | ['Administration, Oral', 'Adolescent', 'Anesthesia, Dental', 'Anesthetics, Inhalation', 'Autistic Disorder', 'Child', 'Child Behavior', 'Child, Preschool', 'Conscious Sedation', 'Cross-Over Studies', 'Dental Care for Disabled', 'Diazepam', 'Double-Blind Method', 'Female', 'Humans', 'Hypnotics and Sedatives', 'Male', 'M... | 16,173,223 | [['E02.319.267.100'], ['M01.060.057'], ['E03.155.141', 'E06.045'], ['D27.505.696.277.100.035.060', 'D27.505.954.427.210.100.035.060'], ['F03.625.164.113.500'], ['M01.060.406'], ['F01.145.179'], ['M01.060.406.448'], ['E03.250'], ['E05.318.370.150', 'N05.715.360.325.150', 'N06.850.520.445.150'], ['E06.170.310', 'N02.421.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Quantitative study of the somatosensory sensitization underlying cross-modal plasticity. | Loss of one sensory modality can cause other types to become more perceptive (cross-modal plasticity). To test the hypothesis that the loss of vision changes the perceptual threshold in the somatosensory system, we applied optogenetics to directly manipulate the afferent inputs involved in the whisker-barrel system usi... | ['Animals', 'Conditioning, Psychological', 'Female', 'Grooming', 'Light', 'Male', 'Mechanoreceptors', 'Neuronal Plasticity', 'Optogenetics', 'Peripheral Nerves', 'Rats', 'Rats, Transgenic', 'Sensory Thresholds', 'Somatosensory Cortex', 'Time Factors', 'Touch', 'Trigeminal Ganglion', 'Vibrissae', 'Vision, Ocular'] | 30,517,160 | [['B01.050'], ['F02.463.425.179'], ['F01.145.113.111.453'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['A08.675.650.915.750', 'A08.800.950.750', 'A11.671.650.915.750'], ['G11.561.638'], ['E05.393.667'], ['A08.800.800'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.136.7... | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Laser for optical thrombolysis and facilitation of balloon angioplasty in acute myocardial infarction following failed pharmacologic thrombolysis. | This report discusses a new indication for the use of holmium:YAG laser. It includes facilitation of thrombolysis and plaque ablation in acute myocardial infarction after failure of thrombolytic agents. Further study is required to define optimal utilization and integration of this novel device for patients who fail to... | ['Angioplasty, Balloon, Laser-Assisted', 'Combined Modality Therapy', 'Coronary Angiography', 'Coronary Thrombosis', 'Equipment Design', 'Female', 'Humans', 'Middle Aged', 'Myocardial Infarction', 'Thrombolytic Therapy', 'Treatment Failure'] | 7,489,590 | [['E02.148.050.060.105', 'E02.148.050.075.080', 'E02.594.060.080', 'E04.014.520.060.080', 'E04.100.814.529.124.060.105', 'E04.100.814.529.124.075.080', 'E04.502.382.124.060.105', 'E04.502.382.124.075.080', 'E05.157.016.060.105', 'E05.157.016.075.080'], ['E02.186'], ['E01.370.350.130.625', 'E01.370.350.700.060.200', 'E0... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Childhood leukaemia in North West England 1954-1977: epidemiology, incidence and survival. | The annual incidence of leukaemia among children aged up to 14 years as estimated by the Manchester Children's Tumour Registry has been analysed for the 24 years 1954-1977. A significant increase in acute lymphoid leukaemia (ALL) was found, while the incidence of acute myeloid leukaemia (AML) remained constant. Other t... | ['Adolescent', 'Age Factors', 'Child', 'Child, Preschool', 'England', 'Female', 'Humans', 'Infant', 'Infant, Newborn', 'Leukemia', 'Leukemia, Lymphoid', 'Leukocyte Count', 'Male', 'Retrospective Studies', 'Sex Factors'] | 6,939,448 | [['M01.060.057'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.406'], ['M01.060.406.448'], ['Z01.542.363.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['C04.557.337'], ['C04.557.337.428', 'C15.604.515.560', 'C20.683.515.528'], ['E01.370.225.500.195.107.595', 'E01.370... | ['Named Groups [M]', 'Health Care [N]', 'Geographicals [Z]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Radiological Evaluation of Artificial Stone Silicosis Outbreak: Emphasizing Findings in Lung Transplant Recipients. | OBJECTIVE: The aim of this study was to describe the computed tomography (CT) findings and correlate pulmonary function tests (PFTs) of silicosis patients with emphasis on the findings in lung transplantation (LTX) recipients.METHODS: We studied the chest CT scans from 82 marble workers exposed to artificial stone dust... | ['Disease Outbreaks', 'Humans', 'Israel', 'Lung Transplantation', 'Male', 'Middle Aged', 'Mining', 'Occupational Exposure', 'Prevalence', 'Pulmonary Fibrosis', 'Radiography, Thoracic', 'Risk Factors', 'Silicosis', 'Tomography, X-Ray Computed'] | 27,680,410 | [['N06.850.290'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.245.500.375'], ['E04.928.600.495', 'E04.936.450.495'], ['M01.060.116.630'], ['J01.576.655.875.500'], ['N06.850.460.350.600'], ['E05.318.308.985.525.750', 'N01.224.935.597.750', 'N06.850.505.400.975.525.750', 'N06.850.520.308.985.525.750'], ['C... | ['Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
Non-contact confocal microscopy of the tear film in unoperated eyes. | PURPOSE: The NIDEK ConfoScan4 (CS4) is a digital scanning slit confocal microscope. The corneal structure and tear film can be viewed, magnified, measured, and photographed at magnifications up to 500x, in vivo, in a noninvasive manner. The objective of this study was to evaluate and illustrate various conditions relat... | ['Conjunctivitis', 'Conjunctivitis, Allergic', 'Diagnosis, Computer-Assisted', 'Disability Evaluation', 'Dry Eye Syndromes', 'Humans', 'Infections', 'Microscopy, Confocal', 'Pilot Projects', 'Severity of Illness Index', 'Tears', 'Visual Acuity'] | 17,455,839 | [['C11.187.183'], ['C11.187.183.200', 'C20.543.480.200'], ['E01.158', 'L01.313.500.750.100.158'], ['E01.370.400'], ['C11.496.260'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C01'], ['E01.370.350.515.395', 'E05.595.395'], ['E05.318.372.750', 'E05.337.737', 'N05.715.360.330.720', 'N06.850.520.450.720'], ['E05.31... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Organisms [B]', 'Health Care [N]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
[Anniversary of profile preparing of air physicians on the department of organization and tactics of medical service]. | The article presents stages of forming of heading of organization and tactics of medical service of the Air Forces in MMedA by Kirov S.M. (OTMS AF). The Academy celebrates the 50th anniversary in 2009 year. The following directions were basic ones of scientific searches in department OTMS: elaboration of system of trea... | ['Anniversaries and Special Events', 'Education, Medical', 'History, 20th Century', 'History, 21st Century', 'Humans', 'Military Medicine', 'Russia'] | 20,120,361 | [['K01.400.095', 'N04.452.822.070'], ['I02.358.399'], ['K01.400.504.968'], ['K01.400.504.984'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H02.403.500'], ['Z01.252.122.500', 'Z01.542.248.775']] | ['Humanities [K]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 |
Escherichia coli virulence patterns may help to predict vesicoureteral reflux in paediatric urinary tract infections. | AIM: Ultrasound and biological tools are used to predict high-grade vesicoureteral reflux, but other markers are needed to better select patients who need voiding cystography. Our aim was to determine whether studying Escherichia coli virulence factors would help to predict vesicoureteral reflux in patients with their ... | ['Adhesins, Bacterial', 'Bacterial Toxins', 'Bacteriuria', 'Escherichia coli', 'Female', 'Humans', 'Infant', 'Male', 'Retrospective Studies', 'Vesico-Ureteral Reflux', 'Virulence Factors'] | 26,099,938 | [['D12.776.097.120.050', 'D12.776.543.100.050', 'D23.050.161.050'], ['D23.946.123'], ['C01.915.219', 'C12.777.892.219', 'C13.351.968.892.219'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750',... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Comparison of sodium and potassium intake with excretion. | Nine well-motivated adults, knowledgeable about nutrition, kept food records, saved food portions equal to what had been eaten, and collected 24-hour urine samples for 3 consecutive days. Estimates of sodium and potassium intake were calculated from food table analyses of written food records and from flame photometric... | ['Creatinine', 'Female', 'Humans', 'Male', 'Potassium', 'Sodium', 'Time Factors'] | 7,419,270 | [['D03.383.129.308.207'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.268.549.550', 'D01.268.557.575', 'D01.552.528.652', 'D01.552.547.650'], ['D01.268.549.750', 'D01.268.557.650', 'D01.552.528.850', 'D01.552.547.725'], ['G01.910.857']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Suffering for science: the effects of implicit social demands on response to experimentally induced pain. | In two experiments subjects rated their pain during baseline trials of cold pressor and finger pressure pain. After various instructional treatments, they were posttested with these same stimuli. As in previous studies, we found in both experiments that coping suggestions significantly reduced reported pain. Experiment... | ['Adolescent', 'Adult', 'Cognition', 'Cold Temperature', 'Female', 'Humans', 'Hypnosis', 'Male', 'Pain', 'Pressure', 'Research Design', 'Suggestion'] | 6,737,210 | [['M01.060.057'], ['M01.060.116'], ['F02.463.188'], ['G01.906.595.272', 'G16.500.275.063.725.710.300', 'G16.500.750.775.710.300', 'N06.230.300.100.725.154', 'N06.230.300.100.725.710.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.190.525.217', 'F04.754.424'], ['C23.888.592.612', 'F02.830.816.444', 'G11.56... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Clinical response to ertapenem in severe community-acquired pneumonia: a retrospective series in an elderly population. | To evaluate in routine hospital practice the clinical response to ertapenem in comparison with other parenteral antibiotics in the treatment of community-acquired pneumonia (CAP), clinical records from patients with severe CAP treated with ertapenem from July 2002 to June 2006 in seven Spanish hospitals were retrospect... | ['Aged', 'Aged, 80 and over', 'Anti-Bacterial Agents', 'Case-Control Studies', 'Community-Acquired Infections', 'Ertapenem', 'Female', 'Hospitals', 'Humans', 'Length of Stay', 'Male', 'Pneumonia', 'Retrospective Studies', 'Severity of Illness Index', 'Spain', 'Treatment Outcome', 'beta-Lactams'] | 19,548,926 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.954.122.085'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['C01.234'], ['D02.065.589.099.124.225', 'D03.633.100.300.124.225'], ['N02.278.421'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.760.400.480', 'N02.421.585.4... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Transcranial color-coded Doppler assessment of cerebral arteriovenous malformation hemodynamics in patients treated surgically or with staged embolization. | OBJECTIVE: The etiology of hemodynamic disturbances following embolization or surgical resection of arteriovenous malformations (AVMs) has not been fully explained. The aim of the study was the assessment of the selected hemodynamic parameters in patients treated for cerebral AVMs using transcranial color-coded Doppler... | ['Adolescent', 'Blood Flow Velocity', 'Cerebrovascular Circulation', 'Embolization, Therapeutic', 'Female', 'Hemodynamics', 'Humans', 'Intracranial Arteriovenous Malformations', 'Male', 'Middle Aged', 'Neurosurgical Procedures', 'Ultrasonography, Doppler, Transcranial', 'Young Adult'] | 24,309,152 | [['M01.060.057'], ['E01.370.370.130', 'G09.330.380.630.080'], ['G09.330.100.159'], ['E02.520.360', 'E02.926.500'], ['G09.330.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.228.140.300.520', 'C10.500.190.500', 'C14.240.850.750.295', 'C14.240.850.875.500', 'C14.907.150.295', 'C14.907.253.560.400', 'C16.131... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Minocycline suppresses interleukine-6, its receptor system and signaling pathways and impairs migration, invasion and adhesion capacity of ovarian cancer cells: in vitro and in vivo studies. | Interleukin (IL)-6 has been shown to be a major contributing factor in growth and progression of ovarian cancer. The cytokine exerts pro-tumorigenic activity through activation of several signaling pathways in particular signal transducer and activator of transcription (STAT3) and extracellular signal-regulated kinase ... | ['Active Transport, Cell Nucleus', 'Animals', 'Cell Adhesion', 'Cell Line, Tumor', 'Cell Movement', 'Cell Nucleus', 'Estrogens, Catechol', 'Female', 'Gene Expression Regulation, Neoplastic', 'Humans', 'Interleukin-1beta', 'Interleukin-6', 'Matrix Metalloproteinase 2', 'Matrix Metalloproteinase 9', 'Mice', 'Minocycline'... | 23,593,315 | [['G03.143.310.100', 'G03.143.700.100'], ['B01.050'], ['G04.022'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.198', 'G07.568.500.180'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['D02.455.426.559.389.657.166.350', 'D06.472.334.851.437.984'], ['G05.308.370'], ['B01.050.150.900.649.313.988.400.112.400.400'],... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Reliability of the rapid Streptococcus A test]. | The results of three second-generation immune assays for direct detection of group A streptococcus were compared in 65 patients with acute pharyngitis. The assays included Strep A Plus, (Abbott), Concise Strep A (Hybritech) and Cards Plus (Pacific Biotech). A standard culture was used as reference. Additionally a nucle... | ['Adolescent', 'Adult', 'Bacterial Outer Membrane Proteins', 'Bacterial Proteins', 'Bacteriological Techniques', 'Child', 'DNA Probes', 'Female', 'Humans', 'Immunoassay', 'Male', 'Membrane Glycoproteins', 'Middle Aged', 'Nucleic Acid Hybridization', 'Pharyngitis', 'Sensitivity and Specificity', 'Streptococcal Infection... | 8,926,181 | [['M01.060.057'], ['M01.060.116'], ['D12.776.097.120', 'D12.776.543.100'], ['D12.776.097'], ['E01.370.225.875.150', 'E05.200.875.150'], ['M01.060.406'], ['D13.444.600.223', 'D27.505.259.750.600.223', 'D27.720.470.530.600.223'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.478.566', 'E05.601.470'], ['D12.776.3... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Challenging expectancies to prevent nonmedical prescription stimulant use: a randomized, controlled trial. | BACKGROUND: College students continue to report nonmedical prescription stimulant use to enhance alertness and concentration. Despite increasing prevalence of this behavior, techniques for preventing or treating it are lacking. An intervention that focuses on challenging positive consequence-oriented beliefs about pres... | ['Adolescent', 'Alcoholism', 'Central Nervous System Stimulants', 'Data Interpretation, Statistical', 'Female', 'Guilt', 'Humans', 'Linear Models', 'Male', 'Marijuana Abuse', 'Methylphenidate', 'Nootropic Agents', 'Prescription Drug Diversion', 'Prospective Studies', 'Risk', 'Social Behavior', 'Students', 'Substance-Re... | 23,570,818 | [['M01.060.057'], ['C25.775.100.250', 'F03.900.100.350'], ['D27.505.696.282', 'D27.505.954.427.220'], ['E05.245.380', 'E05.318.740.300', 'L01.313.500.750.190.380', 'N05.715.360.750.300', 'N06.850.520.830.300'], ['F01.470.483'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.500', 'E05.318.740.750.42... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes... | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 |
A method for removal of low frequency components associated with head movements from dual-axis swallowing accelerometry signals. | Head movements can greatly affect swallowing accelerometry signals. In this paper, we implement a spline-based approach to remove low frequency components associated with these motions. Our approach was tested using both synthetic and real data. Synthetic signals were used to perform a comparative analysis of the splin... | ['Adolescent', 'Adult', 'Aged', 'Algorithms', 'Deglutition', 'Head Movements', 'Humans', 'Middle Aged', 'Motion', 'Reproducibility of Results', 'Signal Processing, Computer-Assisted', 'Young Adult'] | 22,479,402 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['G17.035', 'L01.224.050'], ['G10.261.178'], ['G11.427.410.478'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['G01.482'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['L01.224.800'], ['M01.060.116.81... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Comparison of analgesic effects and patient tolerability of nabilone and dihydrocodeine for chronic neuropathic pain: randomised, crossover, double blind study. | OBJECTIVE: To compare the analgesic efficacy and side effects of the synthetic cannabinoid nabilone with those of the weak opioid dihydrocodeine for chronic neuropathic pain.DESIGN: Randomised, double blind, crossover trial of 14 weeks' duration comparing dihydrocodeine and nabilone.SETTING: Outpatient units of three h... | ['Adult', 'Aged', 'Aged, 80 and over', 'Analgesics, Opioid', 'Chronic Disease', 'Codeine', 'Cross-Over Studies', 'Double-Blind Method', 'Dronabinol', 'Humans', 'Middle Aged', 'Pain', 'Treatment Outcome'] | 18,182,416 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.696.277.600.500', 'D27.505.696.663.850.014.760.500', 'D27.505.954.427.040.550.500', 'D27.505.954.427.210.600.500'], ['C23.550.291.500'], ['D03.132.577.249.562.149', 'D03.605.497.607.204', 'D03.633.400.686.607.204', 'D04.615.723.795.576.149'], ['E... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Kidney transplantation in the cyclosporine era. | Seventy-seven patients underwent transplantation, using a cyclosporine-prednisone immunosuppression protocol. No recipients died, and graft survival at one year was 100% for living related donor (LRD) recipients and 84% for cadaver donor (CD) recipients. Nineteen percent of locally harvested, flush-cooled kidney recipi... | ['Cyclosporins', 'Drug Therapy, Combination', 'Female', 'Graft Rejection', 'Humans', 'Kidney Transplantation', 'Male', 'Postoperative Complications', 'Prednisone', 'Renal Dialysis', 'Reoperation', 'Tissue and Organ Procurement'] | 3,304,197 | [['D04.345.566.235', 'D12.644.641.235'], ['E02.319.310'], ['G12.875.545.328'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.870.500', 'E04.936.450.485', 'E04.950.774.400'], ['C23.550.767'], ['D04.210.500.745.432.719.702'], ['E02.870.300', 'E02.912.800'], ['E04.690'], ['N02.421.911']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
The Scarborough express train crash: four case reports. | Four cases are presented of patients who sustained blunt trauma to the epigastrium in a train crash. Two patients sustained a transected pancreas. The mechanism of injury is discussed. | ['Abdominal Injuries', 'Accidents', 'Adult', 'Aged', 'Emergencies', 'Female', 'Humans', 'Male', 'Middle Aged', 'Pancreas', 'Wounds, Nonpenetrating'] | 3,730,080 | [['C26.017'], ['N06.850.135'], ['M01.060.116'], ['M01.060.116.100'], ['C23.550.291.781', 'N06.230.100.083', 'N06.850.376'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['A03.734'], ['C26.974']] | ['Diseases [C]', 'Health Care [N]', 'Named Groups [M]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Design, synthesis, and biological evaluation of 1,3-diarylisoquinolines as novel topoisomerase I catalytic inhibitors. | With a goal of identifying potent topoisomerase (topo) inhibitor, the C4-aromatic ring of the anticancer agent, 3,4-diarylisoquinolone, was strategically shifted to design 1,3-diarylisoquinoline. Twenty-two target compounds were synthesized in three simple and efficient steps. The 1,3-diarylisoquinolines exhibited pote... | ['Antineoplastic Agents', 'Biocatalysis', 'Cell Line, Tumor', 'Cell Proliferation', 'DNA Topoisomerases, Type I', 'Dose-Response Relationship, Drug', 'Drug Design', 'Drug Screening Assays, Antitumor', 'Humans', 'Isoquinolines', 'Molecular Structure', 'Polymerization', 'Structure-Activity Relationship', 'Topoisomerase I... | 29,174,815 | [['D27.505.954.248'], ['G02.111.086', 'G02.130.500', 'G03.105'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.161.750', 'G07.345.249.410.750'], ['D08.811.399.403.483', 'D12.776.157.687.375', 'D12.776.660.720.375'], ['G07.690.773.875', 'G07.690.936.500'], ['E05.290.500', 'H01.158.703.007.338.500', 'H01.181.466.338.500'... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Isolated del(5q) in myeloid malignancies: clinicopathologic and molecular features in 143 consecutive patients. | World Health Organization (WHO) criteria were used to identify 143 consecutive patients (median age 73 years; 90 females) with myeloid neoplasms and isolated del(5q) seen between 1989 and 2009. We have previously reported on 88 (61%) of these patients who met criteria for WHO defined "myelodysplastic syndromes (MDS) wi... | ['Adult', 'Aged', 'Aged, 80 and over', 'Cell Transformation, Neoplastic', 'Chromosome Deletion', 'Chromosomes, Human, Pair 15', 'Female', 'Follow-Up Studies', 'Humans', 'Isocitrate Dehydrogenase', 'Janus Kinase 2', 'Leukemia, Myeloid, Acute', 'Leukocytosis', 'Male', 'Medical Records', 'Middle Aged', 'Mutation', 'Myelod... | 21,523,797 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C04.697.098.500', 'C23.550.727.098.500'], ['C23.550.210.050.500.500', 'G05.365.590.029.530.175', 'G05.365.590.175.050.500.500', 'G05.365.590.762.180', 'G05.558.800.180', 'G05.700.131.500.500'], ['A11.284.187.520.300.370.385', 'G05.360.162.520.300.370.385... | ['Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Geographicals [Z]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Constitutive expression of stromal derived factor-1 by mucosal epithelia and its role in HIV transmission and propagation. | HIV particles that use the chemokine receptor CXCR4 as a coreceptor for entry into cells (X4-HIV) inefficiently transmit infection across mucosal surfaces [1], despite their presence in seminal fluid and mucosal secretions from infected individuals [2] [3] [4]. In addition, although intestinal lymphocytes are susceptib... | ['Chemokine CXCL12', 'Chemokines, CXC', 'HIV', 'Humans', 'Intestinal Mucosa', 'Receptors, CCR5', 'Receptors, CXCR4'] | 10,744,978 | [['D12.644.276.374.200.120.600', 'D12.776.467.374.200.120.600', 'D23.125.300.120.600', 'D23.469.200.120.600', 'D23.529.374.200.120.600'], ['D12.644.276.374.200.120', 'D12.776.467.374.200.120', 'D23.125.300.120', 'D23.469.200.120', 'D23.529.374.200.120'], ['B04.820.650.589.650.350'], ['B01.050.150.900.649.313.988.400.11... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Recollections of general anaesthesia: a survey of anaesthesiological practice. | In order to identify the factors to which patients attach importance when undergoing general anaesthesia, 678 patients were retrospectively asked about their recollections of previous anaesthetics during routine preoperative screening over a period of 14 months. The most frequently mentioned recollections concerned the... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Anesthesia Recovery Period', 'Anesthesia, General', 'Anesthetics', 'Awareness', 'Child', 'Female', 'Humans', 'Hypnotics and Sedatives', 'Male', 'Memory', 'Middle Aged', 'Nausea', 'Patient Satisfaction', 'Preanesthetic Medication', 'Sex Factors', 'Sleep Stages', 'Vom... | 1,466,211 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E03.160', 'E04.614.750.055', 'N02.421.585.753.750.055'], ['E03.155.197'], ['D27.505.696.277.100', 'D27.505.954.427.210.100'], ['F02.463.188.150'], ['M01.060.406'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.277.350', ... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Visualization of membrane rafts using a perylene monoimide derivative and fluorescence lifetime imaging. | A new membrane probe, based on the perylene imide chromophore, with excellent photophysical properties (high absorption coefficient, quantum yield (QY) approximately 1, high photostability) and excited in the visible domain is proposed for the study of membrane rafts. Visualization of separation between the liquid-orde... | ['Lipid Bilayers', 'Membrane Fluidity', 'Membrane Microdomains', 'Microscopy, Fluorescence', 'Molecular Conformation', 'Molecular Probe Techniques', 'Perylene'] | 17,573,424 | [['D10.570.510', 'J01.637.087.500.510'], ['G01.154.500', 'G02.111.550', 'G04.570'], ['A11.284.149.165.570'], ['E01.370.350.515.458', 'E05.595.458'], ['G02.111.570.820'], ['E05.601'], ['D02.455.426.559.847.149.700', 'D02.455.426.559.847.680.500', 'D04.615.149.700', 'D04.615.680.500']] | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Visual functions after laser photocoagulation in central serous chorioretinopathy. | The authors evalute the visual functions of patients with unilateral central serous chorioretinopathy (CSC) and compare them with their non-affected eye and with a control group. Fourteen patients with CSC treated with direct laser-photocoagulation were examined preoperatively and followed-up, up to 2 years postoperati... | ['Adult', 'Central Serous Chorioretinopathy', 'Contrast Sensitivity', 'Female', 'Humans', 'Laser Coagulation', 'Male', 'Middle Aged', 'Visual Acuity'] | 21,171,526 | [['M01.060.116'], ['C11.768.175'], ['E01.370.380.850.950.500', 'F02.463.593.778.435.110', 'F02.463.593.932.281', 'F02.463.593.932.901.500', 'G14.940.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.520.745.410', 'E02.594.530', 'E04.014.520.530', 'E04.350.750.410', 'E04.540.630.410'], ['M01.060.116.630'], [... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Sodium nitrite blocks the activity of aminoglycosides against Pseudomonas aeruginosa biofilms. | Sodium nitrite has broad antimicrobial activity at pH 6.5, including the ability to prevent biofilm growth by Pseudomonas aeruginosa on the surfaces of airway epithelial cells. Because of its antimicrobial activity, nitrite is being investigated as an inhaled agent for chronic P. aeruginosa airway infections in cystic ... | ['Aminoglycosides', 'Anti-Bacterial Agents', 'Biofilms', 'Microbial Sensitivity Tests', 'Pseudomonas aeruginosa', 'Sodium Nitrite'] | 25,801,569 | [['D09.408.051'], ['D27.505.954.122.085'], ['A20.593', 'G06.120'], ['E01.370.225.875.595', 'E05.200.875.595', 'E05.337.550.400'], ['B03.440.400.425.625.625.100', 'B03.660.250.580.590.050'], ['D01.625.600.600.800', 'D01.857.775']] | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Use of guanidine hydrochloride and ammonium sulfate in comprehensive in-line sorption enrichment of xenobiotics in biological fluids by high-performance liquid chromatography. | A novel approach has been developed for direct injection of physiological fluids on an in-line extraction pre-column followed by column switching in order to introduce the adsorbed xenobiotic onto the analytical column. The physiological fluid is pre-treated with guanidinium solution in water (200 microliters of fluid ... | ['Ammonium Sulfate', 'Chromatography, High Pressure Liquid', 'Guanidine', 'Guanidines', 'Humans', 'Indicators and Reagents', 'Organophosphate Poisoning', 'Solvents', 'Spectrophotometry, Ultraviolet', 'Xenobiotics'] | 8,468,376 | [['D01.625.062.374', 'D01.875.800.800.850.050'], ['E05.196.181.400.300'], ['D02.078.370.472'], ['D02.078.370'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.720.470.410'], ['C25.723.717'], ['D27.720.844'], ['E05.196.712.726.802', 'E05.196.867.826.802'], ['D26.969']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Human trophoblast invasion. Autocrine control and paracrine modulation. | Development of the human placenta involves rapid invasion of the uterine wall by fetal trophoblasts, a process with certain similarities to tumor cell invasion. Unlike tumor invasion, however, this unique interaction between genetically dissimilar trophoblast and uterine cells is closely regulated and limited both temp... | ['Animals', 'Cell Differentiation', 'Cytokines', 'Female', 'Growth Substances', 'Hormones', 'Humans', 'Placenta', 'Pregnancy', 'Trophoblasts', 'Uterus'] | 7,978,909 | [['B01.050'], ['G04.152'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['D27.505.696.377'], ['D06.472', 'D27.505.696.399.472'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A16.710'], ['G08.686.784.769'], ['A11.382.992', 'A16.254.500.766', 'A16.710.802'], ['A05.360.319.679']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Health psychology: psychological adjustment to chronic disease. | Chronic diseases carry important psychological and social consequences that demand significant psychological adjustment. The literature is providing increasingly nuanced conceptualizations of adjustment, demonstrating that the experience of chronic disease necessitates adaptation in multiple life domains. Heterogeneity... | ['Adaptation, Psychological', 'Arthritis, Rheumatoid', 'Behavioral Medicine', 'Cardiovascular Diseases', 'Character', 'Chronic Disease', 'Cultural Characteristics', 'Gender Identity', 'Humans', 'Individuality', 'Internal-External Control', 'Motivation', 'Neoplasms', 'Quality of Life', 'Sick Role', 'Social Support', 'So... | 16,930,096 | [['F01.058'], ['C05.550.114.154', 'C05.799.114', 'C17.300.775.099', 'C20.111.199'], ['F04.096.080', 'H02.403.090'], ['C14'], ['F01.752.190'], ['C23.550.291.500'], ['I01.076.201.450.324', 'I01.880.853.100.329'], ['F01.393.446.250', 'F01.752.747.385.200', 'F01.752.747.722.200', 'F02.739.794.793.200'], ['B01.050.150.900.6... | ['Psychiatry and Psychology [F]', 'Diseases [C]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Humanities [K]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 |
Factors influencing suicidal ideation among Chinese patients with stomach cancer: qualitative study. | AIM: The aim of this qualitative descriptive study was to explore the influencing factors of suicidal ideation in Chinese patients diagnosed with stomach cancer.INTRODUCTION: More recently, links have been made between suicide and cancer. For inpatients with cancer, nurses are at the front line to cope with suicidal is... | ['Adult', 'Aged', 'Aged, 80 and over', 'Asian Continental Ancestry Group', 'Depression', 'Female', 'Humans', 'Male', 'Middle Aged', 'Qualitative Research', 'Stomach Neoplasms', 'Suicidal Ideation', 'Surveys and Questionnaires'] | 27,995,609 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['M01.686.508.200'], ['F01.145.126.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['H01.770.644.241.850'], ['C04.588.274.476.767', 'C06.301.371.767', 'C06.405.249.767', 'C06.405.748.789'], ['F01.145.126.980.875.149', 'I01.880.... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 |
Polarized expression of GABA transporters in Madin-Darby canine kidney cells and cultured hippocampal neurons. | At least three high affinity Na+- and Cl--dependent gamma-aminobutyric acid (GABA) transporters are known to exist in the rat and mouse brain. These transporters share 50-65% amino acid sequence identity with the kidney betaine transporter which also transports GABA but with lower affinity. The betaine transporter (BGT... | ['Amino Acid Sequence', 'Animals', 'Axons', 'Base Sequence', 'Carrier Proteins', 'Cell Line', 'DNA Primers', 'DNA, Complementary', 'Dogs', 'GABA Plasma Membrane Transport Proteins', 'Hippocampus', 'Kidney', 'Membrane Proteins', 'Membrane Transport Proteins', 'Microinjections', 'Molecular Sequence Data', 'Neurons', 'Org... | 8,636,119 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['A08.675.542.145', 'A11.284.180.075', 'A11.671.137', 'A11.671.501.145'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D12.776.157'], ['A11.251.210'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['D13.444.308.497.220', 'D13.444.60... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Cytogenetics of vesper mice, Calomys (Sigmodontinae): a new karyotype from the Puna region and its implication for chromosomal phylogeny. | The karyotype of specimens identified as Calomys lepidus, trapped at 3600 m above sea level in the Puna region, northwestern Argentina, was studied. All specimens analysed showed a 2n = 44 (NF(a) = 68) asymmetrical karyotype with 13 pairs of metacentric/submetacentric autosomes and 7 pairs of telocentric chromosomes. T... | ['Animals', 'Argentina', 'Biological Evolution', 'Chromosome Banding', 'Chromosomes, Mammalian', 'Female', 'Karyotyping', 'Male', 'Phylogeny', 'Sigmodontinae', 'Spermatozoa', 'X Chromosome'] | 19,492,477 | [['B01.050'], ['Z01.107.757.077'], ['G05.045', 'G16.075'], ['E01.370.225.500.385.130', 'E01.370.225.500.620.670.130', 'E01.370.225.750.600.670.130', 'E05.200.500.385.130', 'E05.200.500.620.670.130', 'E05.200.750.600.670.130', 'E05.242.385.130', 'E05.393.285.130'], ['A11.284.187.520', 'G05.360.162.520'], ['E01.370.225.5... | ['Organisms [B]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Information Science [L]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 |
Polymorphisms in the protein C gene as risk factor for venous thrombosis. | Protein C is an important inhibitor of blood coagulation. We investigated the effect of two polymorphisms within the promoter region of the protein C gene (C/T at position 2405 and A/G at position 2418) on risk of venous thrombosis and on plasma protein C levels. In addition the combined effect of the two polymorphisms... | ['Adult', 'Aged', 'Case-Control Studies', 'Contraceptives, Oral', 'Factor V', 'Female', 'Gene Frequency', 'Genetic Predisposition to Disease', 'Haplotypes', 'Humans', 'Male', 'Middle Aged', 'Odds Ratio', 'Phenotype', 'Polymorphism, Single Nucleotide', 'Promoter Regions, Genetic', 'Protein C', 'Risk Assessment', 'Risk F... | 19,132,190 | [['M01.060.116'], ['M01.060.116.100'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['D27.505.696.875.360.276.210', 'D27.505.954.705.360.276.210'], ['D12.776.124.125.300', 'D12.776.811.272', 'D23.119.300'], ['G05.330'], ['C23.550.291.687.500', 'G05.380.355'], ['G05.380.360'], ['B01.050... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Annoyance due to air pollution in Europe. | BACKGROUND: Annoyance due to air pollution is a subjective score of air quality, which has been incorporated into the National Environmental monitoring of some countries. The objectives of this study are to describe the variations in annoyance due to air pollution in Europe and its individual and environmental determin... | ['Adult', 'Air Pollutants', 'Air Pollution', 'Anger', 'Educational Status', 'Environmental Monitoring', 'Europe', 'Female', 'Humans', 'Inhalation Exposure', 'Linear Models', 'Male', 'Middle Aged', 'Multivariate Analysis', 'Respiratory Tract Diseases', 'Sex Factors', 'Sulfur Dioxide', 'Tobacco Smoke Pollution', 'Urban P... | 17,470,482 | [['M01.060.116'], ['D27.888.284.101'], ['N06.850.460.100'], ['F01.470.093'], ['N01.824.196'], ['N06.850.460.350.080', 'N06.850.780.375'], ['Z01.542'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N06.850.460.350.112'], ['E05.318.740.500.500', 'E05.318.740.750.425', 'E05.599.835.750', 'N05.715.360.750.530.460', 'N... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Determining content for a simulation-based curriculum in pediatric emergency medicine: results from a national Delphi process. | OBJECTIVES: By the end of residency training, pediatric emergency medicine (PEM) residents are expected to have developed the confidence and abilities required to manage acutely ill children. Acquisition of competence requires exposure and/or supplemental formal education for critical and noncritical medical clinical p... | ['Canada', 'Child', 'Clinical Competence', 'Computer Simulation', 'Curriculum', 'Delphi Technique', 'Education, Medical, Graduate', 'Emergency Medicine', 'Humans', 'Internship and Residency', 'Pediatric Emergency Medicine', 'Pediatrics'] | 25,989,837 | [['Z01.107.567.176'], ['M01.060.406'], ['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['L01.224.160'], ['I02.158'], ['L01.906.197'], ['I02.358.337.350', 'I02.358.399.350'], ['H02.403.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I02.358.337.350.500', 'I02.358.399.350.750'], ['H02.403.250.500', 'H02.403.... | ['Geographicals [Z]', 'Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Information Science [L]', 'Disciplines and Occupations [H]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
Fade or fate. Seroma in laparoscopic inguinal hernia repair. | BACKGROUND: Postoperative fluid collection in the space left behind the dissected hernia sac in laparoscopic herniorraphy puts the surgeon in a dilemma as to whether it is a recurrence or a seroma, and it is not always easily judged only by physical examination (PE). Another important issue is what kind of seroma can b... | ['Adult', 'Aged', 'Hernia, Inguinal', 'Humans', 'Laparoscopy', 'Male', 'Middle Aged', 'Physical Examination', 'Postoperative Period', 'Remission, Spontaneous', 'Seroma', 'Time Factors', 'Ultrasonography'] | 16,333,536 | [['M01.060.116'], ['M01.060.116.100'], ['C23.300.707.374.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.388.250.520', 'E04.502.250.520'], ['M01.060.116.630'], ['E01.370.600'], ['E04.614.750', 'N02.421.585.753.750'], ['C23.550.291.656.700', 'G16.767'], ['C23.550.470.640'], ['G01.910.857'], ['E01.370.3... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Change implementation: the association of adaptive reserve and burnout among inpatient medicine physicians and nurses. | Adaptive Reserve (AR) is positively associated with implementing change in ambulatory settings. Deficits in AR may lead to change fatigue or burnout. We studied the association of self-reported AR and burnout among providers to hospitalized medicine patients in an academic medical center. An electronic survey containin... | ['Attitude of Health Personnel', 'Burnout, Professional', 'Burnout, Psychological', 'Humans', 'Job Satisfaction', 'Medical Staff, Hospital', 'Nursing Staff, Hospital', 'Surveys and Questionnaires', 'Workforce'] | 29,558,229 | [['F01.100.050', 'N05.300.100'], ['C24.580.500', 'F01.145.126.990.367.500', 'F02.830.900.333.500'], ['F01.145.126.990.367', 'F02.830.900.333'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.784.692.425'], ['M01.526.485.630.490', 'M01.526.485.740.422', 'N02.360.630.490', 'N02.360.740.422'], ['M01.526.485.680.49... | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Evaluation of glucose as a cryoprotectant for boar semen. | Fertility parameters of boar spermatozoa were evaluated in vitro, after freeze-thawing the semen in three different extenders containing permeable and non-permeable cryoprotectants: A (111.0 mM Tris, 31.4 mM citric acid, 185.0 mM glucose, 20 per cent egg yolk, 3 per cent glycerol and 100 iu/ml penicillin G); B (200 mM ... | ['Acrosome', 'Animals', 'Cryoprotective Agents', 'Female', 'Fertility', 'Glucose', 'Male', 'Microscopy, Phase-Contrast', 'Semen', 'Semen Preservation', 'Sperm Motility', 'Sperm-Ovum Interactions', 'Spermatozoa', 'Swine'] | 12,418,531 | [['A05.360.490.890.820.100', 'A11.284.430.214.190.875.190.550.040', 'A11.497.760.400.100'], ['B01.050'], ['D27.505.696.706.320', 'D27.720.799.180'], ['G08.686.210'], ['D09.947.875.359.448'], ['E01.370.350.515.513.569', 'E05.490.630.569', 'E05.595.513.569'], ['A12.200.732'], ['E02.792.833.890', 'E05.760.833.890'], ['E01... | ['Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of direction and rate of ear-canal pressure changes on tympanometric measures. | The effects of the direction (ascending and descending) and rate (12.5, 25.0, and 50.0 daPa/s) of ear-canal pressure changes on three tympanometric measures (peak static admittance, shape, and tympanometric peak pressure) were studied in 24 adults with normal middle-ear transmission systems. Susceptance, conductance, a... | ['Acoustic Impedance Tests', 'Acoustics', 'Adult', 'Ear Canal', 'Humans', 'Pressure'] | 3,702,371 | [['E01.370.382.375.050'], ['H01.671.031'], ['M01.060.116'], ['A09.246.272.396'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.374.715']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
CXC chemokine ligand 10 neutralization suppresses the occurrence of diabetes in nonobese diabetic mice through enhanced beta cell proliferation without affecting insulitis. | We have shown that neutralization of IFN-inducible protein 10/CXCL10, a chemokine for Th1 cells, breaks Th1 retention in the draining lymph nodes, resulting in exacerbation in Th1-dominant autoimmune disease models induced by immunization with external Ags. However, there have been no studies on the role of CXCL10 neut... | ['Animals', 'Antibodies, Blocking', 'Antibodies, Monoclonal', 'Cell Proliferation', 'Chemokine CXCL10', 'Chemokines, CXC', 'Chemotaxis, Leukocyte', 'Cyclophosphamide', 'Diabetes Mellitus, Type 1', 'Disease Progression', 'Female', 'Immunosuppression', 'Injections, Intraperitoneal', 'Islets of Langerhans', 'Mice', 'Mice,... | 15,557,199 | [['B01.050'], ['D12.776.124.486.485.114.143', 'D12.776.124.790.651.114.143', 'D12.776.377.715.548.114.143'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['G04.161.750', 'G07.345.249.410.750'], ['D12.644.276.374.200.120.500', 'D12.776.467.374.200.120.500', 'D23.125.300.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Multicentric development of pancreatic intraductal carcinoma through atypical papillary hyperplasia. | We report a case of multiple intraductal carcinomas of the pancreas associated with diffuse atypical papillary hyperplasia. A 67-year-old Japanese man with a complaint of epigastric pain was examined by endoscopic retrograde pancreatography, which demonstrated multiple dilated branches of the pancreatic duct in the bod... | ['Aged', 'Carcinoma, Intraductal, Noninfiltrating', 'Cell Transformation, Neoplastic', 'Humans', 'Hyperplasia', 'Male', 'Pancreatic Neoplasms'] | 1,312,058 | [['M01.060.116.100'], ['C04.557.470.200.025.275', 'C04.557.470.200.240.187.250', 'C04.557.470.615.275'], ['C04.697.098.500', 'C23.550.727.098.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.444'], ['C04.588.274.761', 'C04.588.322.475', 'C06.301.761', 'C06.689.667', 'C19.344.421']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Screening women for gonorrhea: demographic screening criteria for general clinical use. | OBJECTIVES: The purpose of this analysis was to derive potential gonorrhea screening criteria for women.METHODS: Data corresponding to 44,366 gonorrhea cultures from women 15 through 44 years of age in Columbus, Ohio, were analyzed.RESULTS: Characteristics that were associated with gonococcal infection and were suitabl... | ['Adolescent', 'Adult', 'Age Factors', 'Female', 'Gonorrhea', 'Humans', 'Logistic Models', 'Marital Status', 'Mass Screening', 'Ohio', 'Prevalence', 'ROC Curve', 'Sensitivity and Specificity', 'Urban Population'] | 9,314,811 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['C01.150.252.400.625.275', 'C01.150.252.734.401', 'C01.221.812.281.401', 'C01.778.281.401', 'C12.294.668.281.401', 'C13.351.500.711.281.401'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.525', 'E05.318.740.600.800.450', '... | ['Named Groups [M]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
A novel peptide-modified and gene-activated biomimetic bone matrix accelerating bone regeneration. | The osteogenic differentiation of bone marrow stromal cells (BMSCs) can be regulated by systemic or local growth factor, especially by transforming growth factor beta 1 (TGF-â1). However, how to maintain the bioactivity of exogenous TGF-â1 is a great challenge due to its short half-life time. The most promising solutio... | ['Alkaline Phosphatase', 'Animals', 'Aspartic Acid', 'Biomechanical Phenomena', 'Biomimetic Materials', 'Bone Matrix', 'Bone Regeneration', 'Bone Transplantation', 'Collagen Type I', 'Femur', 'Lactic Acid', 'Mesenchymal Stem Cells', 'Osteocalcin', 'Osteogenesis', 'Peptides', 'Phenotype', 'Polyethylene Glycols', 'Polygl... | 24,115,366 | [['D08.811.277.352.650.035'], ['B01.050'], ['D12.125.067.500', 'D12.125.119.170', 'D12.125.427.040'], ['G01.154.090', 'G01.374.089'], ['J01.637.087'], ['A10.165.265.166'], ['G11.427.213.140', 'G16.762.150.150'], ['E02.095.147.725.052', 'E04.555.130', 'E04.936.580.052'], ['D05.750.078.280.300.100', 'D12.776.860.300.250.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Interplay of Supersaturation and Solubilization: Lack of Correlation between Concentration-Based Supersaturation Measurements and Membrane Transport Rates in Simulated and Aspirated Human Fluids. | Supersaturating formulations are increasingly being used to improve the absorption of orally administered poorly water-soluble drugs. To better predict outcomes in vivo, we must be able to accurately determine the degree of supersaturation in complex media designed to provide a surrogate for the gastrointestinal enviro... | ['Atazanavir Sulfate', 'Biological Transport', 'Body Fluids', 'Chemistry, Pharmaceutical', 'Crystallization', 'Diffusion', 'Humans', 'Kinetics', 'Solubility', 'Thermodynamics', 'Triazoles'] | 31,638,397 | [['D03.383.725.068', 'D12.644.456.157'], ['G03.143'], ['A12.207'], ['H01.158.703.007', 'H01.181.466'], ['E05.196.300', 'G02.171'], ['G01.202', 'G02.196'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.374.661', 'G02.111.490'], ['G02.805'], ['G01.906'], ['D03.383.129.799']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
An epidemiological model of rinderpest. II. Simulations of the behaviour of rinderpest virus in populations. | Fixed parameters for different hypothetical strains of rinderpest virus (RV) and different susceptible populations are described together with details of their derivation. Simulations were then carried out in a computer model to determine the effects that varying these parameters would have on the behaviour of RV in th... | ['Animals', 'Cattle', 'Computer Simulation', 'Disease Susceptibility', 'Immunity, Active', 'Probability', 'Rinderpest', 'Rinderpest virus', 'Seasons', 'Vaccination', 'Viral Vaccines', 'Virulence'] | 2,711,465 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['L01.224.160'], ['C23.550.291.687', 'G07.100.250'], ['G12.450.050.370'], ['E05.318.740.600', 'G17.680', 'N05.715.360.750.625', 'N06.850.520.830.600'], ['C01.925.782.580.600.500.700', 'C22.780'], ['B04.820.480.937.600.650.500.675'], ['G01.910.645.661', 'G16.500.275... | ['Organisms [B]', 'Information Science [L]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Sucrose, sodium dodecyl sulfate, urea, and 2-mercaptoethanol affect the thermal inactivation of R-phycoerythrin. | Thermal inactivation kinetics (D- and z-values) of the algal protein, R-phycoerythrin (R-PE), were studied under different buffer conditions (pH 4.0, 7.0, and 10.0) and concentrations of sucrose, sodium dodecyl sulfate (SDS), urea, and 2-mercaptoethanol (ME). R-PE solutions were heated in capillary tubes at temperature... | ['Fluorescence', 'Hot Temperature', 'Hydrogen-Ion Concentration', 'Mercaptoethanol', 'Phycoerythrin', 'Sodium Dodecyl Sulfate', 'Sucrose', 'Temperature', 'Time Factors', 'Urea'] | 11,726,163 | [['G01.358.500.505.650.665.500', 'G01.590.540.665.500'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.775.710.380', 'N06.230.300.100.725.232', 'N06.230.300.100.725.710.380'], ['G02.300'], ['D02.033.375.534', 'D02.886.489.409'], ['D05.500.562.488.490.500.500.777', 'D08.811.600.710.490.500.500.777', 'D... | ['Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Intestinal barrier integrity in patients with plaque psoriasis. | Psoriasis is a chronic inflammatory systemic disease. Growing evidence suggests that human homeostasis depends on a mutualistic relationship with gut bacteria that produce a number of biologically active compounds. Therefore, enteric microbiota dysbiosis with gut barrier disruption may be an important factor in the dev... | ['Adult', 'Case-Control Studies', 'Claudin-3', 'Dysbiosis', 'Enterocytes', 'Fatty Acid-Binding Proteins', 'Female', 'Gastrointestinal Microbiome', 'Humans', 'Intestinal Mucosa', 'Male', 'Middle Aged', 'Permeability', 'Psoriasis', 'Tight Junctions', 'Young Adult'] | 30,222,202 | [['M01.060.116'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['D12.776.543.940.200.300'], ['C23.550.308'], ['A03.556.124.369.290', 'A10.615.550.444.290', 'A11.436.290'], ['D12.776.157.170'], ['G06.591.375', 'G16.500.275.157.049.100.500.375', 'N06.230.124.049.100.500.250'], ['B01.050.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Expression of UreB and HspA of Helicobacter pylori in silkworm pupae and identification of its immunogenicity. | For mass production of urease B subunit (UreB) and heat shock protein A subunit (HspA) of Helicobacter pylori with Bombyx mori nuclear polyhedrosis virus (BmNPV) baculovirus expression system (BES) and to determine whether they could be used as an oral vaccine against H. pylori, besides, to determine the time course of... | ['Animals', 'Bacterial Proteins', 'Bombyx', 'Female', 'Green Fluorescent Proteins', 'Heat-Shock Proteins', 'Helicobacter pylori', 'Humans', 'Mice', 'Mice, Inbred BALB C', 'Molecular Sequence Data', 'Protein Subunits', 'Pupa', 'Recombinant Fusion Proteins', 'Urease'] | 20,127,514 | [['B01.050'], ['D12.776.097'], ['B01.050.500.131.617.720.500.500.937.650.100'], ['D12.776.532.265'], ['D12.776.580.216'], ['B03.440.500.550', 'B03.660.150.235.500.250.550'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.338', 'B01.050.150.900.649... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Information Science [L]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Preampullary congenital duodenal obstruction in a father and son. | This is the report of an infant seen on June 25, 1960 with preampullary total duodenal obstruction caused by a combined annular pancreas and duodenal stenosis above the ampulla. A gastroduodenostomy was performed. In December 1989, he fathered a 1,700-g boy with preampullary duodenal atresia. A duodeno-duodenostomy was... | ['Adult', 'Duodenal Obstruction', 'Duodenostomy', 'Humans', 'Infant, Newborn', 'Intestinal Atresia', 'Male'] | 8,301,499 | [['M01.060.116'], ['C06.405.469.275.395', 'C06.405.469.531.311'], ['E04.210.338.303', 'E04.579.338.303'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['C06.198.719', 'C06.405.469.445', 'C16.131.314.466']] | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
An oligonucleotide complementary to the SL-B1 domain in the 3'-end of the minus-strand RNA of the hepatitis C virus inhibits in vitro initiation of RNA synthesis by the viral polymerase. | We describe oligonucleotides (ODNs) that inhibit hepatitis C virus (HCV) RNA synthesis in vitro. From a series of 13 ODNs complementary to the 3'-end of the minus-strand HCV RNA, only 4 inhibited RNA synthesis with IC(50) values lower than 1 microM. The inhibition was sequence-specific, since no effect was observed whe... | ["3' Untranslated Regions", 'Base Sequence', 'Genetic Complementation Test', 'Hepacivirus', 'Molecular Sequence Data', 'Oligonucleotides', 'RNA, Viral', 'RNA-Dependent RNA Polymerase', 'Viral Nonstructural Proteins'] | 14,517,074 | [['D13.444.735.544.875.880', 'D13.444.735.790.878.880', 'G05.360.340.024.220.880.880', 'G05.360.340.024.340.137.910.880'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.393.281.526'], ['B04.450.380', 'B04.820.578.344.475'], ['L01.453.245.667'], ['D13.695.578.424'], ['D13.444.735.828'], ['D08.811.913.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Stunting is associated with poor outcomes in childhood pneumonia. | OBJECTIVE: Stunting affects 26.7% of children worldwide, and little is known about its effects on the outcomes of childhood pneumonia. We evaluated the effect of stunting on the outcomes of pneumonia among children enrolled in two large clinical trials.METHODS: We analysed data from two WHO and USAID-sponsored inpatien... | ['Amoxicillin', 'Anti-Bacterial Agents', 'Child, Preschool', 'Female', 'Growth Disorders', 'Humans', 'Infant', 'Male', 'Penicillins', 'Pneumonia', 'Risk Factors', 'Time Factors', 'Treatment Outcome'] | 26,083,963 | [['D02.065.589.099.750.750.050.050', 'D02.886.108.750.750.050.050', 'D03.633.100.300.750.750.050.050'], ['D27.505.954.122.085'], ['M01.060.406.448'], ['C23.550.393'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['D02.065.589.099.750', 'D02.886.108.750', 'D03.633.100.300.750'], ['C01.748.610', 'C08... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Carbon tetrachloride-induced alterations of hepatic calmodulin and free calcium levels in rats pretreated with chlordecone. | Calmodulin, a low molecular weight Ca2+ binding protein, regulates a large number of cell activities including cell division. Previous studies from our laboratory indicated excessive accumulation of Ca2+ in hepatocytes succeeded by rapid glycogen breakdown and suppressed cell division in rats receiving CCl4 after previ... | ['Alanine Transaminase', 'Animals', 'Aspartate Aminotransferases', 'Calcium', 'Calmodulin', 'Carbon Tetrachloride', 'Chemical and Drug Induced Liver Injury', 'Chlordecone', 'Cyclic AMP', 'Drug Synergism', 'Liver', 'Liver Diseases', 'Male', 'Phosphorylase a', 'Rats', 'Rats, Inbred Strains', 'Subcellular Fractions'] | 1,704,867 | [['D08.811.913.477.700.100'], ['B01.050'], ['D08.811.913.477.700.225'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D12.644.360.372.249', 'D12.776.157.125.412.249', 'D12.776.476.387.249'], ['D02.455.526.439.150'], ['C06.552.100', 'C25.100.562', 'C25.723.260'], ['D02.455.526.439.190'], ['D03.633.100.759.646... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Influence of recovery method and microbial contamination on the response to freezing-thawing in ibex (Capra pyrenaica) epididymal spermatozoa. | The method of sperm recovery may influence the initial quality of sperm samples and their response to freezing-thawing. The aim of the present work was to compare two methods for collecting epididymal spermatozoa in order to improve the quality of recovered sperm and reduce possible contamination. Testes were obtained ... | ['Acrosome', 'Animals', 'Cryopreservation', 'Goats', 'Male', 'Semen Preservation', 'Specimen Handling', 'Sperm Motility', 'Spermatozoa', 'Therapeutic Irrigation'] | 19,786,008 | [['A05.360.490.890.820.100', 'A11.284.430.214.190.875.190.550.040', 'A11.497.760.400.100'], ['B01.050'], ['E01.370.225.500.620.760.160', 'E01.370.225.750.600.760.160', 'E02.792.156', 'E05.200.500.620.760.160', 'E05.200.750.600.760.160', 'E05.760.156'], ['B01.050.150.900.649.313.500.380.513'], ['E02.792.833.890', 'E05.7... | ['Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Confronting the challenge of computerization for social workers in health care settings. | Computerization and information technology will profoundly affect the work of health care social workers in the coming years. This paper reviews recent trends in information technology in health care systems and their implications for social workers. It describes recent innovations in information systems designed speci... | ['Attitude to Computers', 'Computer User Training', 'Hospital Departments', 'Hospital Information Systems', 'Humans', 'Social Work Department, Hospital', 'Software', 'Task Performance and Analysis', 'United States'] | 2,633,052 | [['F01.100.100'], ['I02.903.080'], ['N02.278.216.500.968', 'N04.452.442.452.422'], ['N04.452.442.452.452', 'N04.452.515.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N02.278.216.500.968.730', 'N04.452.442.452.422.730'], ['L01.224.900'], ['F02.784.412.846', 'F02.784.692.746', 'F02.808.600'], ['Z01.107.567.87... | ['Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Information Science [L]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 1 |
Contribution of 24 obesity-associated genetic variants to insulin resistance, pancreatic beta-cell function and type 2 diabetes risk in the French population. | CONTEXT: Obesity is the major determinant of type 2 diabetes (T2D), presumably through its effect on insulin resistance. Genome-wide association studies reported many single-nucleotide polymorphisms (SNPs) that increase obesity risk and body mass index (BMI), but their impact on T2D-related traits and risk is unclear.O... | ['Adult', 'Aged', 'Alpha-Ketoglutarate-Dependent Dioxygenase FTO', 'Body Mass Index', 'Cyclin-Dependent Kinase 5', 'Diabetes Mellitus, Type 2', 'European Continental Ancestry Group', 'Female', 'France', 'Genetic Predisposition to Disease', 'Genetic Variation', 'Genome-Wide Association Study', 'Genotype', 'Homeostasis',... | 23,090,577 | [['M01.060.116'], ['M01.060.116.100'], ['D08.811.074.062.968', 'D08.811.682.662.582.242', 'D08.811.682.690.416.139.992'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['D08.811.913.696.620.682.700.646.500.500.500', 'D12.644.360.250.067.875', 'D12.776.167.200.067.875', 'D... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]', 'Geographicals [Z]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Microscopic evaluation of the ventricular tissue using stereological and Voronoi tessellation methods: Application on doxorubicin-induced cardiotoxicity in rats. | There is limited quantitative microscopic information concerning the three-dimensional arrangement of cardiomyocytes and microvessels in cardiotoxic condition. The aim of this study was to evaluate the cardiac tissue of rats under different experimental conditions using modern second-order stereology and Voronoi tessel... | ['Animals', 'Antibiotics, Antineoplastic', 'Cardiotoxicity', 'Doxorubicin', 'Heart Ventricles', 'Image Processing, Computer-Assisted', 'Microscopy', 'Myocardium', 'Rats, Sprague-Dawley'] | 28,558,328 | [['B01.050'], ['D27.505.954.248.106'], ['C14.280.260', 'C23.550.161', 'C25.100.389', 'C26.733.266', 'G01.750.748.500.266'], ['D02.455.426.559.847.562.050.200.175', 'D04.615.562.050.200.175', 'D09.408.051.059.200.175'], ['A07.541.560'], ['L01.224.308'], ['E01.370.350.515', 'E05.595', 'H01.671.617.562'], ['A02.633.580', ... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Detection of caprine arthritis-encephalitis virus by polymerase chain reaction. | Detection of caprine arthritis-encephalitis virus (CAEV) infection in goats is currently limited to serologic testing or cell culture. We developed a polymerase chain reaction (PCR) assay to detect CAEV sequences in peripheral blood mononuclear cells (PBMC), synovial fluid cells (SFC), and milk cells (MC) obtained from... | ['Animals', 'Arthritis, Infectious', 'Base Sequence', 'Encephalomyelitis', 'Goats', 'Lentivirus', 'Lentivirus Infections', 'Molecular Sequence Data', 'Polymerase Chain Reaction'] | 8,263,195 | [['B01.050'], ['C01.100', 'C05.550.114.099'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['C01.207.291', 'C10.228.228.291', 'C10.228.440'], ['B01.050.150.900.649.313.500.380.513'], ['B04.820.650.589'], ['C01.925.782.815.616'], ['L01.453.245.667'], ['E05.393.620.500']] | ['Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
[Effect of hot water extract of Korean ginseng on neuroblastoma cell parthanatos]. | OBJECTIVE: To explore the effect of pretreatment of neuroblastoma cells with hot water extract of Korean ginseng on MNNG-induced parthanatos and its mechanism.METHODS: Neuroblastoma SH-SY5Y cells were pretreated with 1 mg/L hot water extract of Korean ginseng before induction with 250 ìmol/L MNNG for 1 h or 4 h. CCK-8 ... | ['Apoptosis Inducing Factor', 'Humans', 'Neuroblastoma', 'Panax', 'Parthanatos', 'Republic of Korea'] | 32,990,232 | [['D08.811.682.608.047', 'D12.644.360.075.311', 'D12.776.157.687.063', 'D12.776.331.161', 'D12.776.476.075.311', 'D12.776.660.720.063'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.465.625.600.590.650.550', 'C04.557.470.670.590.650.550', 'C04.557.580.625.600.590.650.550'], ['B01.650.940.800.575.912.250.0... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Relationship among knowledge acquisition, motivation to change, and self-efficacy in CME participants. | INTRODUCTION: The relationship among an individual's sense of self-efficacy, motivation to change, barriers to change, and the implementation of improvement programs has been reported. This research reports the relationship among self-efficacy, motivation to change, and the acquisition of knowledge in a continuing medi... | ['Adult', 'Education, Medical, Continuing', 'Female', 'Humans', 'Learning', 'Male', 'Middle Aged', 'Motivation', 'Self Efficacy', 'Surveys and Questionnaires'] | 26,115,236 | [['M01.060.116'], ['I02.358.212.350', 'I02.358.399.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.425', 'F02.784.629.529'], ['M01.060.116.630'], ['F01.658', 'F01.752.543.500.750'], ['F01.752.747.792.700'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980']] | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Psychotic-Like Experiences in Offspring of Parents With Bipolar Disorder and Community Controls: A Longitudinal Study. | OBJECTIVE: To compare the prevalence and risk factors associated with psychotic-like experiences (PLE) in offspring of parents with bipolar disorder (BP) and offspring of community control parents.METHOD: Delusional and hallucinatory subclinical psychotic experiences were evaluated at intake and longitudinally in a coh... | ['Adolescent', 'Adult', 'Bipolar Disorder', 'Child', 'Child of Impaired Parents', 'Female', 'Humans', 'Longitudinal Studies', 'Male', 'Parent-Child Relations', 'Parents', 'Prevalence', 'Proportional Hazards Models', 'Psychotic Disorders', 'Risk Factors', 'Young Adult'] | 30,768,403 | [['M01.060.057'], ['M01.060.116'], ['F03.084.500'], ['M01.060.406'], ['M01.106'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.500.750.500', 'N05.715.360.330.500.750.500', 'N06.850.520.450.500.750.500'], ['F01.829.263.370.290'], ['F01.829.263.500.320', 'I01.880.853.150.500.340', 'M01.620'], ['E05.318.... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Diagnosis of subdural haematoma by computed axial tomography: use of xenon inhalation for contrast enhancement. | A subdural haematoma is described in which a definite computed tomographic (CT) scan diagnosis was made only after contrast enhancement had been achieved by the inhalation of xenon. The different types of enhancement obtained with iodide containing contrast media and with xenon are discussed. The use of xenon to obtain... | ['Contrast Media', 'Hematoma, Subdural', 'Humans', 'Male', 'Middle Aged', 'Radiographic Image Enhancement', 'Tomography, X-Ray Computed', 'Xenon'] | 650,246 | [['D27.505.259.500', 'D27.720.259'], ['C10.228.140.300.535.450.400', 'C10.900.300.837.600', 'C14.907.253.573.400.450', 'C23.550.414.838.700', 'C23.550.414.913.700', 'C26.915.300.490.450'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.370.350.600.350.700', 'E01.370.350.700.700', 'L01.224.3... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Successful application of a simple specimen transport method for the conduct of respiratory virus surveillance in remote Indigenous communities in Australia. | OBJECTIVE: Surveillance programs and research for acute respiratory infections in remote Aboriginal communities are complicated by difficulties in the storage and transport of frozen samples to urban laboratories for testing. This study assessed the sensitivity of a simple method for transporting respiratory samples fr... | ['Acute Disease', 'Adolescent', 'Adult', 'Australia', 'Child', 'Child, Preschool', 'Cryopreservation', 'Female', 'Humans', 'Infant', 'Infant, Newborn', 'Male', 'Medically Underserved Area', 'Nasal Cavity', 'Oceanic Ancestry Group', 'Polymerase Chain Reaction', 'Population Surveillance', 'Postal Service', 'Respiratory T... | 21,418,445 | [['C23.550.291.125'], ['M01.060.057'], ['M01.060.116'], ['Z01.639.100', 'Z01.678.100.373'], ['M01.060.406'], ['M01.060.406.448'], ['E01.370.225.500.620.760.160', 'E01.370.225.750.600.760.160', 'E02.792.156', 'E05.200.500.620.760.160', 'E05.200.750.600.760.160', 'E05.760.156'], ['B01.050.150.900.649.313.988.400.112.400.... | ['Diseases [C]', 'Named Groups [M]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Anatomy [A]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
A solitary large radioiodine accumulative lung lesion in high-dose 131i therapeutic scan: bronchial atresia with mucocele. | We reported a large radioiodine accumulative lung lesion on I therapeutic whole-body scan performed in a 50-year-old woman for thyroid cancer ablation therapy. Previously, her chest radiography and contrast-enhanced chest CT images showed bronchial atresia in the left upper lobar bronchus and mucus-filled dilated dista... | ['Bronchi', 'Carcinoma', 'Carcinoma, Papillary', 'Female', 'Humans', 'Iodine Radioisotopes', 'Middle Aged', 'Mucocele', 'Radiopharmaceuticals', 'Thyroid Cancer, Papillary', 'Thyroid Neoplasms', 'Tomography, Emission-Computed, Single-Photon', 'Tomography, X-Ray Computed'] | 24,978,338 | [['A04.411.125'], ['C04.557.470.200'], ['C04.557.470.200.360', 'C04.557.470.700.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.268.380.400.500.496', 'D01.496.448.496', 'D01.496.749.474'], ['M01.060.116.630'], ['C04.182.511'], ['D27.505.259.843', 'D27.505.519.871', 'D27.720.470.410.650'], ['C04.557.470.20... | ['Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Teratoma formation in immunocompetent mice after syngeneic and allogeneic implantation of germline capable mouse embryonic stem cells. | BACKGROUND: Embryonic stem cells (ESCs) have the potential to form teratomas when implanted into immunodeficient mice, but data in immunocompetent mice are limited. We therefore investigated teratoma formation after implantation of three different mouse ESC (mESC) lines into immunocompetent mice.MATERIALS AND METHODS: ... | ['Animals', 'Cell Differentiation', 'Cell Line', 'Embryonic Stem Cells', 'Mice', 'Mice, Inbred BALB C', 'Mice, Inbred C57BL', 'Teratoma'] | 24,289,566 | [['B01.050'], ['G04.152'], ['A11.251.210'], ['A11.872.700.250'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.338', 'B01.050.150.900.649.313.992.635.505.500.400.338'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420'], ['C04.557.465.910']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Lipoprotein profile, lipoprotein-associated phospholipase A2 and cardiovascular risk in hemodialysis patients. | BACKGROUND: Cardiovascular disease is the leading cause of morbidity and mortality in hemodialysis patients; the increased risk of cardiovascular disease is due to accelerated atherosclerosis, inflammation and impaired lipoprotein metabolism. We aimed to evaluate lipoprotein-associated phospholipase A2 (Lp-PLA2) and so... | ['1-Alkyl-2-acetylglycerophosphocholine Esterase', 'Adult', 'Aged', 'Aged, 80 and over', 'Apolipoprotein A-I', 'Apolipoproteins B', 'Atherosclerosis', 'C-Reactive Protein', 'Cardiovascular Diseases', 'Case-Control Studies', 'Ceruloplasmin', 'Cholesterol', 'Female', 'Follow-Up Studies', 'Humans', 'Lipoproteins, HDL', 'L... | 25,971,848 | [['D08.811.277.352.100.680.750.937.249'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D10.532.091.200.100', 'D12.776.070.400.200.100', 'D12.776.521.120.200.100'], ['D10.532.091.300', 'D12.776.070.400.300', 'D12.776.521.120.300'], ['C14.907.137.126.307'], ['D12.776.034.145', 'D12.776.124.050.120', '... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Sex-Related Differences in the Sensitivity to Carcinogenic Effect of Urethane on the Lungs in Mice Are Reversed after Neonatal Androgenization. | Experiments on male and female CC57BR/Mv mice differing by the sensitivity to carcinogenic effect of urethane on the lungs showed that castration 1 week before carcinogen challenge reduced the number of lung adenomas caused by it in males and somewhat increased the number of tumors in females. Exogenous testosterone af... | ['Animals', 'Animals, Newborn', 'Carcinogenicity Tests', 'Carcinogens', 'Dose-Response Relationship, Drug', 'Drug Resistance', 'Female', 'Lung', 'Lung Neoplasms', 'Male', 'Mice', 'Pregnancy', 'Sex Characteristics', 'Urethane', 'Virilism'] | 26,515,180 | [['B01.050'], ['B01.050.050.282'], ['E05.940.150'], ['D27.888.569.100'], ['G07.690.773.875', 'G07.690.936.500'], ['G07.690.773.984'], ['A04.411'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['B01.050.150.900.649.313.992.635.505.500'], ['G08.686.784.769'], ['G08.686.815'], ['D02.241.081.251.944'], ['C23.888.... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The myosin motor in muscle generates a smaller and slower working stroke at higher load. | Muscle contraction is driven by the motor protein myosin II, which binds transiently to an actin filament, generates a unitary filament displacement or 'working stroke', then detaches and repeats the cycle. The stroke size has been measured previously using isolated myosin II molecules at low load, with rather variable... | ['Animals', 'Biomechanical Phenomena', 'Isometric Contraction', 'Molecular Motor Proteins', 'Muscle Fibers, Skeletal', 'Muscle, Skeletal', 'Myosin Type II', 'Ranidae', 'X-Rays'] | 15,058,307 | [['B01.050'], ['G01.154.090', 'G01.374.089'], ['G11.427.494.472'], ['D05.500.500', 'D08.811.277.040.025.193'], ['A10.690.552.500.500', 'A11.620.249'], ['A02.633.567', 'A10.690.552.500'], ['D05.750.078.730.475.475', 'D08.811.277.040.025.193.750.750', 'D12.776.210.500.600.470', 'D12.776.220.525.475.475'], ['B01.050.150.9... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Gender differences in restricted and repetitive behaviors and interests in youth with autism. | Previous work has found gender differences in restricted and repetitive behaviors and interests (RRBI) for autism spectrum disorder (ASD). Compared to girls, affected boys have increased stereotyped and restricted behaviors; however much less is known about gender differences in other areas of RRBI. This study aims to ... | ['Adolescent', 'Autism Spectrum Disorder', 'Child', 'Child, Preschool', 'Female', 'Humans', 'Male', 'Sex Factors', 'Stereotyped Behavior'] | 30,561,911 | [['M01.060.057'], ['F03.625.164.113'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N05.715.350.675', 'N06.850.490.875'], ['F01.145.896']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Quantification of collateral blood flow in coarctation of the aorta by velocity encoded cine magnetic resonance imaging. | BACKGROUND: Knowledge about the volume of collateral flow provides insight into the severity of coarctation of the aorta and may be critical in planning the operative approach. There is currently no method for the quantification of collateral flow in coarctation of the aorta. In this study, we applied velocity encoded ... | ['Aorta, Thoracic', 'Aortic Coarctation', 'Blood Flow Velocity', 'Child', 'Collateral Circulation', 'Female', 'Humans', 'Image Processing, Computer-Assisted', 'Linear Models', 'Magnetic Resonance Imaging', 'Male', 'Observer Variation'] | 8,044,965 | [['A07.015.114.056.372'], ['C14.240.400.090', 'C14.280.400.090', 'C16.131.240.400.090'], ['E01.370.370.130', 'G09.330.380.630.080'], ['M01.060.406'], ['G09.330.100.248'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['E05.318.740.500.500', 'E05.318.740.750.425', 'E05.599.835.750', 'N05.715.360.750.... | ['Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Named Groups [M]', 'Organisms [B]', 'Information Science [L]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
The significance of aryl acylamidase activity of acetylcholinesterase in osteoblast differentiation and mineralization. | Osteoblast differentiation is an essential event in the developmental process, which is favoured by the production of extra cellular matrix proteins and various enzymes including discrete ones like acetylcholinesterase (AChE). Despite the fact that AChE facilitates osteoblast differentiation, the significance of its ca... | ['Acetylcholinesterase', 'Amidohydrolases', 'Antigens, Differentiation', 'Calcification, Physiologic', 'Cell Differentiation', 'Cell Line, Tumor', 'GPI-Linked Proteins', 'Humans', 'Osteoblasts'] | 28,852,920 | [['D08.811.277.352.100.170.176'], ['D08.811.277.087'], ['D23.050.301.264', 'D23.101.100'], ['G07.345.155.500', 'G07.345.500.325.377.625.050.500.175', 'G11.427.578.050.500.175'], ['G04.152'], ['A11.251.210.190', 'A11.251.860.180'], ['D12.776.395.550.448', 'D12.776.543.484.500', 'D12.776.543.550.418'], ['B01.050.150.900.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Is comprehension necessary for error detection? A conflict-based account of monitoring in speech production. | Despite the existence of speech errors, verbal communication is successful because speakers can detect (and correct) their errors. The standard theory of speech-error detection, the perceptual-loop account, posits that the comprehension system monitors production output for errors. Such a comprehension-based monitor, h... | ['Adult', 'Aphasia', 'Comprehension', 'Computer Simulation', 'Female', 'Humans', 'Language', 'Male', 'Middle Aged', 'Models, Psychological', 'Speech', 'Speech Production Measurement'] | 21,652,015 | [['M01.060.116'], ['C10.597.606.150.500.800.100', 'C23.888.592.604.150.500.800.100'], ['F02.463.188.357'], ['L01.224.160'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.209.399', 'L01.559'], ['M01.060.116.630'], ['E05.599.695'], ['F01.145.209.908.677', 'G11.561.812', 'L01.559.423.676'], ['E01.370.760']] | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Vitamin D3 abates BDL-induced cholestasis and fibrosis in rats via regulating Hedgehog pathway. | Liver cholestasis is a complex disease of broad etiologies. Hedgehog (Hh) signaling has been shown to play a pivotal role in modulating liver repair post cholestatic liver injury. We here investigated the role of vitamin D in experimental liver cholestasis induced by bile-duct ligation (BDL) in rats. Male Sprague Dawle... | ['Animals', 'Bile Ducts', 'Cholecalciferol', 'Cholestasis', 'Extracellular Matrix Proteins', 'Hedgehog Proteins', 'Ligation', 'Liver', 'Liver Cirrhosis', 'Male', 'Molecular Docking Simulation', 'Rats, Sprague-Dawley', 'Signal Transduction', 'Smoothened Receptor', 'Transforming Growth Factor beta', 'Vitamins', 'Zinc Fin... | 31,394,158 | [['B01.050'], ['A03.159.183'], ['D04.210.500.247.222.159', 'D04.210.500.247.808.146', 'D04.210.500.812.768.196', 'D10.570.938.146'], ['C06.130.120.135'], ['D12.776.860.300'], ['D12.644.276.671', 'D12.776.467.671', 'D23.529.671'], ['E04.426'], ['A03.620'], ['C06.552.630', 'C23.550.355.412'], ['E05.599.595.249', 'L01.224... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
The ipsilateral cortico-cortical connexions between the cytoarchitectonic subdivisions of the primary somatic sensory cortex in the monkey. | The ipsilateral cortico-cortical connexions passing between the architectonic subdivisions of the primary somatic sensory cortex, S1, of the monkey have been studied with axonal degeneration methods after the placement of small lesions. All architectonic subdivisions except area 3a, and all the topographic representati... | ['Animals', 'Brain Mapping', 'Macaca', 'Neural Pathways', 'Somatosensory Cortex'] | 3,995,355 | [['B01.050'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['B01.050.150.900.649.313.988.400.112.199.120.510'], ['A08.612'], ['A08.186.211.200.885.287.500.670.675', 'A08.186.211.200.885.287.500.814.906']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Umbilical venous Doppler velocity pulsations and inferior vena cava pressure elevations in fetal lambs. | OBJECTIVE: To examine effects of fluid administration on inferior vena cava pressure and umbilical venous Doppler velocities in the term fetal lamb.METHODS: With the ewe given inhalation anesthetics, eight chronically instrumented intrauterine fetal lambs at 125-135 days' gestation were given normal saline fluid boluse... | ['Animals', 'Blood Flow Velocity', 'Blood Pressure', 'Fetus', 'Heart Rate', 'Pulse', 'Sheep', 'Ultrasonography, Doppler', 'Umbilical Veins', 'Vena Cava, Inferior'] | 8,602,319 | [['B01.050'], ['E01.370.370.130', 'G09.330.380.630.080'], ['E01.370.600.875.249', 'G09.330.380.076'], ['A16.378'], ['E01.370.600.875.500', 'G09.330.380.500'], ['E01.370.370.380.650', 'G09.330.380.750'], ['B01.050.150.900.649.313.500.380.791'], ['E01.370.350.850.850'], ['A07.015.908.670.874', 'A16.378.693.807'], ['A07.0... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
When authorship fails. A proposal to make contributors accountable. | A published article is the primary means whereby new work is communicated, priority is established, and academic promotion is determined. Publication depends on trust and requires that authors be held to standards of honesty, completeness, and fairness in their reporting, and to accountability for their statements. The... | ['Authorship', 'Biomedical Research', 'Databases, Bibliographic', 'Disclosure', 'Editorial Policies', 'Information Dissemination', 'Publishing', 'Social Responsibility', 'Trust'] | 9,268,280 | [['L01.559.423.906.215'], ['H01.770.644.145'], ['L01.313.500.750.300.188.300', 'L01.470.750.500'], ['F01.829.401.046', 'I01.880.604.583.080.134', 'L01.143.335'], ['L01.737.484'], ['L01.143.443'], ['L01.737'], ['F01.829.500.760', 'K01.752.566.869'], ['F01.829.401.825']] | ['Information Science [L]', 'Disciplines and Occupations [H]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]'] | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 |
Maintaining hemodynamic stability and myocardial performance during off-pump coronary bypass surgery. | Patients presenting for coronary artery bypass (CAB) surgery are now older and have more comorbid conditions. Off-pump (OPCAB) methods may reduce morbidity and mortality in these higher risk patients. Multivessel surgery has been limited by the difficulty in maintaining hemodynamic stability during lateral wall vessel ... | ['Aged', 'Cardiopulmonary Bypass', 'Coronary Artery Bypass', 'Coronary Disease', 'Female', 'Hemodynamics', 'Humans', 'Intra-Aortic Balloon Pumping', 'Male', 'Middle Aged', 'Postoperative Complications', 'Retrospective Studies'] | 12,607,721 | [['M01.060.116.100'], ['E04.292.413'], ['E04.100.376.719.332', 'E04.100.814.868.750', 'E04.928.220.520.220'], ['C14.280.647.250', 'C14.907.585.250'], ['G09.330.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.050.215.400'], ['M01.060.116.630'], ['C23.550.767'], ['E05.318.372.500.500.500', 'E05.318.372.500.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Expression of GM-CSF in patients with pulmonary alveolar proteinosis]. | OBJECTIVE: To investigate the expression of granulocyte-macrophage colony-stimulating factor (GM-CSF) protein and mRNA in four patients with pulmonary alveolar proteinosis (PAP).METHODS: GM-CSF levels were measured with a commercial ELISA kit. RT-PCR was employed to detect the expression of the GM-CSF mRNA in periphera... | ['Adult', 'Enzyme-Linked Immunosorbent Assay', 'Female', 'Gene Expression', 'Granulocyte-Macrophage Colony-Stimulating Factor', 'Humans', 'Leukocytes, Mononuclear', 'Lipopolysaccharides', 'Macrophages, Alveolar', 'Male', 'Middle Aged', 'Pulmonary Alveolar Proteinosis', 'RNA, Messenger', 'Reverse Transcriptase Polymeras... | 11,802,999 | [['M01.060.116'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['G05.297'], ['D12.644.276.374.410.240.375', 'D12.776.395.240.300', 'D12.776.467.374.410.240.375', 'D23.529.374.410.240.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.118... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Prenatal Choline Supplementation during High-Fat Feeding Improves Long-Term Blood Glucose Control in Male Mouse Offspring. | Maternal obesity increases the risk of metabolic dysregulation in rodent offspring, especially when offspring are exposed to a high-fat (HF), obesogenic diet later in life. We previously demonstrated that maternal choline supplementation (MCS) in HF-fed mouse dams during gestation prevents fetal overgrowth and excess a... | ['Adiposity', 'Animals', 'Blood Glucose', 'Choline', 'Diet, High-Fat', 'Dietary Supplements', 'Female', 'Glucose Intolerance', 'Insulin Receptor Substrate Proteins', 'Intra-Abdominal Fat', 'Male', 'Maternal Nutritional Physiological Phenomena', 'Mice', 'Mice, Inbred C57BL', 'Obesity', 'Pregnancy', 'Prenatal Exposure De... | 31,947,955 | [['E01.370.600.115.100.062.500', 'G02.111.130.134.500', 'G03.180.134.500', 'G07.100.049.134.500'], ['B01.050'], ['D09.947.875.359.448.500'], ['D02.033.100.291.211', 'D02.092.063.291.211', 'D02.092.877.883.333', 'D02.675.276.232'], ['G07.203.650.240.267'], ['G07.203.300.456', 'J02.500.456'], ['C18.452.394.952.500'], ['D... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Identification of endogenous phosphorylation sites of bovine medium and low molecular weight neurofilament proteins by tandem mass spectrometry. | Neurofilament proteins (NFP) are intermediate filaments found in the neuronal cytoskeleton. They are highly phosphorylated, a condition that is believed to be responsible for the assembly and stability of the filaments. Matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) mass spectrometry (MS) show... | ['Amino Acid Motifs', 'Amino Acid Sequence', 'Animals', 'Cattle', 'Chromatography, High Pressure Liquid', 'Molecular Sequence Data', 'Molecular Weight', 'Neurofilament Proteins', 'Peptide Fragments', 'Peptide Mapping', 'Phosphorylation', 'Protein Structure, Tertiary', 'Protein Subunits', 'Sequence Analysis, Protein', '... | 14,967,049 | [['G02.111.570.820.709.275.500', 'G02.111.570.820.709.600.500'], ['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['E05.196.181.400.300'], ['L01.453.245.667'], ['G02.494'], ['D05.750.078.593.630', 'D12.776.220.475.630', 'D12.776.631.630'], ['D12.644.541'], ['E05.196.181.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Belongingness: a prerequisite for nursing students' clinical learning. | The concept of belongingness has intuitive appeal. Human beings are social creatures; the need to belong and be accepted is fundamental, and social exclusion can be devastating. This paper reports on the selected findings from the qualitative phase of mixed-methods study that explored nursing students' experience of be... | ['Clinical Competence', 'Group Processes', 'Humans', 'Interviews as Topic', 'Learning', 'New South Wales', 'Nursing Education Research', 'Preceptorship', 'Psychology, Educational', 'Qualitative Research', 'Queensland', 'Social Alienation', 'Social Environment', 'Social Identification', 'Students, Nursing', 'United King... | 18,291,327 | [['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['F01.829.316'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.420', 'L01.399.250.520', 'N05.715.360.300.400', 'N06.850.520.308.420'], ['F02.463.425', 'F02.784.629.529'], ['Z01.639.100.750', 'Z01.678.100.373.750'], ['H01.770.644.145.390.413', 'H02.478... | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Geographicals [Z]', 'Disciplines and Occupations [H]', 'Named Groups [M]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
The effect of a tin-containing fluoride mouth rinse on the bond between resin composite and erosively demineralised dentin. | OBJECTIVES: To evaluate the effect of a tin-containing fluoride (Sn/F) mouth rinse on microtensile bond strength (ìTBS) between resin composite and erosively demineralised dentin.MATERIALS AND METHODS: Dentin of 120 human molars was erosively demineralised using a 10-day cyclic de- and remineralisation model. For 40 mo... | ['Adhesiveness', 'Cariostatic Agents', 'Collagenases', 'Composite Resins', 'Dental Bonding', 'Dental Materials', 'Dental Stress Analysis', 'Dentin', 'Humans', 'Light-Curing of Dental Adhesives', 'Materials Testing', 'Microscopy, Electron, Scanning', 'Mouthwashes', 'Resin Cements', 'Sodium Fluoride', 'Spectrometry, X-Ra... | 22,431,144 | [['G02.860.139'], ['D25.223', 'D27.505.696.706.222', 'D27.720.102.223', 'D27.720.799.113', 'J01.637.051.223'], ['D08.811.277.656.300.480.205', 'D08.811.277.656.675.374.205'], ['D05.750.716.822.308', 'D25.339.816.500', 'D25.720.716.822.308', 'J01.637.051.339.816.500', 'J01.637.051.720.716.822.308'], ['E06.095'], ['D25.3... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Inhibitory effects of bromocriptine on vascular smooth muscle cell proliferation. | Bromocriptine (BC), an ergot alkaloid with wide therapeutic use in humans, has been shown to inhibit proliferation of several abnormally hyperproliferative cells in vivo and in vitro. In the present study, direct effects of BC on mitogen-stimulated proliferation of rat vascular smooth muscle cells (VSMC) (A7r5 cells) a... | ['Animals', 'Bromocriptine', 'Cell Division', 'Cells, Cultured', 'Dopamine', 'Dopamine Agonists', 'Humans', 'Insulin-Like Growth Factor I', 'Muscle, Smooth, Vascular', 'Platelet-Derived Growth Factor', 'Prolactin', 'Protein Kinase C', 'Rats', 'Receptors, Dopamine D2', 'Tetradecanoylphorbol Acetate'] | 9,258,405 | [['B01.050'], ['D03.132.327.412.100', 'D03.633.400.439.131', 'D03.633.400.562.100'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.251'], ['D02.092.211.215.406', 'D02.092.311.342', 'D02.455.426.559.389.657.166.175.342'], ['D27.505.519.625.150.151', 'D27.505.696.577.150.151'], ['B01.050... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Comparison of preschool children's performance using the Denver developmental test, before and after nutritional intervention]. | UNLABELLED: Psychomotor and development analysis must be emphasized when studying institutionalized children. Many previous investigations have been showing deleterious effects of day care centers over developmental performance in children.OBJECTIVE: This study is aimed at comparing the performance in the Development S... | ['Child', 'Child Day Care Centers', 'Child Development', 'Child Nutritional Physiological Phenomena', 'Child, Preschool', 'Developmental Disabilities', 'Female', 'Food, Fortified', 'Humans', 'Iron, Dietary', 'Male', 'Neuropsychological Tests', 'Nutrition Surveys'] | 9,336,043 | [['M01.060.406'], ['J03.160', 'N02.421.143.098'], ['F01.525.200', 'G07.345.374.750'], ['G07.203.650.220'], ['M01.060.406.448'], ['F03.625.421'], ['G07.203.300.515', 'J02.500.515'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.490.600'], ['F04.711.513'], ['E05.318.308.980.485', 'N05.715.360.300.800.469', 'N06.... | ['Named Groups [M]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
A G/C element mediates repression of the SM22alpha promoter within phenotypically modulated smooth muscle cells in experimental atherosclerosis. | A hallmark of smooth muscle cell (SMC) phenotypic switching in atherosclerotic lesions is suppression of SMC differentiation marker gene expression. Yet little is known regarding the molecular mechanisms that control this process. Here we show that transcription of the SMC differentiation marker gene SM22alpha is reduc... | ['Animals', 'Aorta', 'Apolipoproteins E', 'Arteriosclerosis', 'Becaplermin', 'Cell Differentiation', 'Cells, Cultured', 'Crosses, Genetic', 'Extracellular Matrix Proteins', 'Gene Silencing', 'Genes, Reporter', 'Hypercholesterolemia', 'Lac Operon', 'Mice', 'Mice, Inbred CBA', 'Mice, Transgenic', 'Microfilament Proteins'... | 15,486,317 | [['B01.050'], ['A07.015.114.056'], ['D10.532.091.500', 'D12.776.070.400.500', 'D12.776.521.120.500'], ['C14.907.137.126'], ['D12.644.276.910.650.500', 'D12.776.260.690.500', 'D12.776.467.910.650.500', 'D23.529.910.650.500'], ['G04.152'], ['A11.251'], ['E05.393.281'], ['D12.776.860.300'], ['G05.308.203.374'], ['G05.360.... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[The atypical neuroleptic concept]. | Atypical neuroleptics can be defined as dopamine (DA) receptor blockers which differ from typical neuroleptics in that they have a markedly lower or absent propensity for the induction of parkinsonian side effects of tardive dyskinesias. Some of them, but not all, are also more effective in treating schizophrenic patie... | ['Antipsychotic Agents', 'Humans', 'Psychotic Disorders', 'Receptors, Adrenergic', 'Receptors, Cholinergic', 'Receptors, GABA-A', 'Receptors, Glutamate', 'Receptors, Serotonin', 'Schizophrenia'] | 1,364,079 | [['D27.505.696.277.950.040', 'D27.505.954.427.210.950.040', 'D27.505.954.427.700.872.331'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F03.700.675'], ['D12.776.543.750.670.300.300', 'D12.776.543.750.695.150.300', 'D12.776.543.750.720.330.300'], ['D12.776.543.750.720.360'], ['D12.776.157.530.400.175.562', 'D12.7... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A comparative study of machine-learning methods to predict the effects of single nucleotide polymorphisms on protein function. | MOTIVATION: The large volume of single nucleotide polymorphism data now available motivates the development of methods for distinguishing neutral changes from those which have real biological effects. Here, two different machine-learning methods, decision trees and support vector machines (SVMs), are applied for the fi... | ['Algorithms', 'Animals', 'Artificial Intelligence', 'Caenorhabditis elegans Proteins', 'Cluster Analysis', 'Gene Expression Profiling', 'Pattern Recognition, Automated', 'Polymorphism, Single Nucleotide', 'Proteins', 'Reproducibility of Results', 'Sensitivity and Specificity', 'Sequence Alignment', 'Sequence Analysis,... | 14,630,648 | [['G17.035', 'L01.224.050'], ['B01.050'], ['G17.035.250', 'L01.224.050.375'], ['D12.776.419.500'], ['E05.318.740.250', 'N05.715.360.750.200', 'N06.850.520.830.250'], ['E05.393.332'], ['L01.399.750'], ['G05.365.795.598'], ['D12.776'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['E0... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Characterization of two Streptomyces enzymes that convert ferulic acid to vanillin. | Production of flavors from natural substrates by microbial transformation has become a growing and expanding field of study over the past decades. Vanillin, a major component of vanilla flavor, is a principal flavoring compound used worldwide. Streptomyces sp. strain V-1 is known to be one of the most promising microbi... | ['Bacterial Proteins', 'Benzaldehydes', 'Biocatalysis', 'Biosynthetic Pathways', 'Cloning, Molecular', 'Coenzyme A Ligases', 'Coumaric Acids', 'Enoyl-CoA Hydratase', 'Escherichia coli', 'Hydrogen-Ion Concentration', 'Kinetics', 'Streptomyces', 'Substrate Specificity'] | 23,840,666 | [['D12.776.097'], ['D02.047.222'], ['G02.111.086', 'G02.130.500', 'G03.105'], ['G02.111.098', 'G03.493.100'], ['E05.393.220'], ['D08.811.464.267.500'], ['D02.241.223.200.210'], ['D08.811.520.241.300.250'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['G02.300'], ['G01.374.661', 'G02.111.490'], ['B03.300.390... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Synthesis of a novel histidine analogue and its efficient incorporation into a protein in vivo. | Proteins containing unnatural amino acids have immense potential in biotechnology and medicine. We prepared several histidine analogues including a novel histidine analogue, beta-(1,2,3-triazol-4-yl)-DL-alanine. These histidine analogues were assayed for translational activity in histidine-auxotrophic Escherichia coli ... | ['Bacterial Proteins', 'Cloning, Molecular', 'Escherichia coli', 'Histidine', 'Models, Molecular', 'Molecular Mimicry', 'Mutation'] | 14,560,056 | [['D12.776.097'], ['E05.393.220'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D12.125.072.329', 'D12.125.142.308'], ['E05.599.595'], ['G02.111.560', 'G05.545', 'G16.012.750.500'], ['G05.365.590']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Anti-neutrophil cytoplasmic antibodies (ANCA): a seromarker for Wegener's granulomatosis. | Wegener's granulomatosis can be a difficult diagnosis to establish. It is not uncommon to require repeated biopsies over many months for histologic confirmation. A recently developed seromarker--anti-neutrophil cytoplasm antibody--ANCA (synonymous with anticytoplasmic autoantibody--ACPA) adds a new and valuable tool fo... | ['Autoantibodies', 'Cytoplasm', 'Female', 'Granulomatosis with Polyangiitis', 'Humans', 'Middle Aged', 'Neutrophils', 'Nose Diseases', 'Paranasal Sinus Diseases', 'Serologic Tests'] | 1,920,582 | [['D12.776.124.486.485.114.323', 'D12.776.124.790.651.114.323', 'D12.776.377.715.548.114.323'], ['A11.284.430.214'], ['C08.381.483.950', 'C14.907.940.897.249.750', 'C20.111.193.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['A11.118.637.415.583', 'A11.627.340.583', 'A11.733.689', 'A15.145... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Effect of silicone elastomer contact lens wear on endothelial cell morphology in aphakic eyes. | We prospectively evaluated the effect of extended silicone elastomer contact lens wear on the endothelial mosaic of aphakic subjects. Endothelial cell photography and central corneal thickness measurements were performed on 23 eyes of 15 aphakic subjects (mean age 60 +/- 10 years). These measurements were made before l... | ['Adult', 'Aged', 'Aged, 80 and over', 'Aphakia', 'Contact Lenses, Extended-Wear', 'Endothelium, Corneal', 'Female', 'Humans', 'Longitudinal Studies', 'Male', 'Middle Aged', 'Oxygen', 'Photography', 'Prospective Studies', 'Silicone Elastomers'] | 2,297,994 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C11.510.103'], ['E07.632.500.276.360.220'], ['A09.371.060.067.318', 'A09.371.060.217.318', 'A10.272.491.318'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.500.750.500', 'N05.715.360.330.500.750.500', 'N06.850.520.450.500.750.500'], ['M... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Evaluation of the toxicity of Rh(III) and Pt(II) complexes against Trypanosoma cruzi culture forms. | In the present study the activity of 15 complexes of Rh(III) and 19 of Pt(II) against Trypanosoma cruzi epimastigote forms was investigated. The results obtained show that complexes of Rh(III) with the highest antitumoural activity also appear to be more effective against cultured epimastigotes. Thus, complexes [Rh(L)4... | ['Animals', 'Cisplatin', 'Drug Evaluation, Preclinical', 'Platinum', 'Rhodium', 'Structure-Activity Relationship', 'Trypanosoma cruzi'] | 3,513,774 | [['B01.050'], ['D01.210.375', 'D01.625.125', 'D01.710.100'], ['E05.290.750', 'E05.337.550'], ['D01.268.556.690', 'D01.268.956.734', 'D01.552.544.690'], ['D01.268.556.793', 'D01.268.956.781', 'D01.552.544.793'], ['G02.111.830', 'G07.690.773.997'], ['B01.268.475.868.887.140']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[The preliminary clinical results of laparoscopic ileum augmentation cystoplasty for low compliance bladder]. | OBJECTIVE: To study the effectiveness and safety of the laparoscopic ileal bladder augmentation treatment for low compliance bladder.METHODS: A retrospective analysis was performed based on 36 cases admitted to the Zhejiang Provincial People's Hospital with highly reflective and low compliance bladder accepted laparosc... | ['Adult', 'Anastomosis, Surgical', 'Female', 'Follow-Up Studies', 'Humans', 'Ileum', 'Laparoscopy', 'Male', 'Middle Aged', 'Orthopedic Procedures', 'Postoperative Complications', 'Retrospective Studies', 'Treatment Outcome', 'Urinary Bladder, Overactive', 'Urodynamics', 'Urologic Surgical Procedures', 'Young Adult'] | 26,653,959 | [['M01.060.116'], ['E04.035'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A03.556.124.684.249', 'A03.556.249.124'], ['E01.370.388.250.520', 'E04.502.250.520'], ['M01.060.116.630'], ['E02.718', 'E04.555'], ['C23.550.767'],... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The phenotype of the Arabidopsis cue1 mutant is not simply caused by a general restriction of the shikimate pathway. | The Arabidopsis thalianachlorophyll a/b binding protein underexpressed (cue1) mutant, which has been isolated in a screen for chlorophyll a/b binding protein (CAB) underexpressors, exhibits a reticulate leaf phenotype combined with delayed chloroplast development and aberrant shape of the palisade parenchyma cells. The... | ['Arabidopsis', 'Arabidopsis Proteins', 'Carrier Proteins', 'Chromatography, High Pressure Liquid', 'Light-Harvesting Protein Complexes', 'Membrane Proteins', 'Phenotype', 'Photosynthesis', 'Restriction Mapping', 'Shikimic Acid', 'Signal Transduction', 'Ultraviolet Rays'] | 14,617,088 | [['B01.650.940.800.575.912.250.157.100'], ['D12.776.765.149'], ['D12.776.157'], ['E05.196.181.400.300'], ['D05.500.562.488.490', 'D08.811.600.710.490', 'D12.776.543.930.500.490', 'D12.776.765.199.750.750.490'], ['D12.776.543'], ['G05.695'], ['G02.111.158.937', 'G02.111.669.700', 'G02.740.921', 'G03.191.937', 'G03.493.7... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
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