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National trends in CT use in the emergency department: 1995-2007. | PURPOSE: To identify nationwide trends and factors associated with the use of computed tomography (CT) in the emergency department (ED).MATERIALS AND METHODS: This study was exempt from institutional review board approval. Data from the 1995-2007 National Hospital Ambulatory Medical Care Survey were used to evaluate th... | ['Chi-Square Distribution', 'Emergency Service, Hospital', 'Health Care Surveys', 'Humans', 'Logistic Models', 'Tomography, X-Ray Computed', 'United States'] | 21,115,875 | [['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['N02.278.216.500.968.336', 'N02.421.297.195', 'N04.452.442.452.422.336'], ['E05.318.308.980.344', 'N03.349.380.210', 'N05.425.210', 'N05.715.360.300.800.344', 'N06.850.520.308.980.344'], ['B01.050.150.900.649.313.988.400.112... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Supernumerary ovary. A case report. | To date only 13 cases of histologically confirmed supernumerary ovary have been reported. This case met Wharton's criteria and histologically represents the 14th case. The patient had undergone a transabdominal hysterectomy and bilateral salpingo-oophorectomy for chronic pelvic pain. Several years postoperatively she a... | ['Adult', 'Choristoma', 'Colonic Neoplasms', 'Female', 'Humans', 'Ovary'] | 3,612,636 | [['M01.060.116'], ['C23.300.250'], ['C04.588.274.476.411.307.180', 'C06.301.371.411.307.180', 'C06.405.249.411.307.180', 'C06.405.469.158.356.180', 'C06.405.469.491.307.180'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A05.360.319.114.630', 'A05.360.576.497', 'A06.300.312.497']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Lipid metabolism in the adipose tissues of a carnivore, the raccoon dog, during prolonged fasting. | Previous studies on laboratory rodents, rabbits, and humans have demonstrated that adipose tissue fatty acid (FA) mobilization is selective, and its efficiency is related to the molecular structure of FAs. This study was undertaken to find out whether such preferences of FA mobilization are a general feature of mammali... | ['Animals', 'Fasting', 'Fatty Acids', 'Gas Chromatography-Mass Spectrometry', 'Intra-Abdominal Fat', 'Lipid Mobilization', 'Raccoon Dogs', 'Subcutaneous Fat'] | 17,202,586 | [['B01.050'], ['F01.145.407.400', 'G07.203.650.240.587', 'G07.203.650.353.400'], ['D10.251'], ['E05.196.181.349.500', 'E05.196.566.500'], ['A10.165.114.830.500.500'], ['G03.458.500.500'], ['B01.050.150.900.649.313.750.250.216.700'], ['A10.165.114.830.750']] | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Progressive supranuclear palsy: phenotypic sex differences in a clinical cohort. | We examined sex-based differences in phenotypic expression among a consecutive clinical series of 121 individuals diagnosed with probable progressive supranuclear palsy (PSP). For both men (44%) and women (56%), the age at symptomatic onset (66.2 and 68.5 years, respectively) and disease duration (4.6 and 4.3 years, re... | ['Adult', 'Age of Onset', 'Aged', 'Aged, 80 and over', 'Body Mass Index', 'Cohort Studies', 'Female', 'Humans', 'Male', 'Middle Aged', 'Phenotype', 'Retrospective Studies', 'Severity of Illness Index', 'Sex Characteristics', 'Supranuclear Palsy, Progressive'] | 16,342,256 | [['M01.060.116'], ['N05.715.350.075.100', 'N06.850.490.250.100'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['B01.050.150.900.649.313.988.400.1... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Parathyroid sensing of the direction of change of calcium in uremia. | It could be advantageous for the parathyroids to be able to sense not only the absolute concentration of extracellular Ca2+, but also the rate and direction of change of Ca2+, thereby allowing the parathyroids to respond earlier to threats to Ca2+ homeostasis. By using high and low Ca2+ dialysis in a single session, we... | ['Adult', 'Aged', 'Calcium', 'Female', 'Humans', 'Male', 'Middle Aged', 'Osmolar Concentration', 'Parathyroid Glands', 'Regression Analysis', 'Time Factors', 'Uremia'] | 8,510,389 | [['M01.060.116'], ['M01.060.116.100'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['G02.640'], ['A06.300.560'], ['E05.318.740.750', 'N05.715.360.750.695', 'N06.850.520.830.750'], ['G01.910.857'], ['C12.777.419.936', 'C13.351.968.419.936']... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Measurement of ankle brachial index for assessment of atherosclerosis in patients with stroke. | BACKGROUND: Though atherosclerosis is generally regarded as a risk factor for stroke, its quantitative assessment in patients with stroke has not yet been reported. Recently, the ankle brachial index (ABI) has been receiving increasing attention as a noninvasive measurement of atherosclerosis. In this study, we investi... | ['Aged', 'Ankle', 'Arteriosclerosis', 'Brachial Artery', 'Brain Ischemia', 'Female', 'Humans', 'Logistic Models', 'Male', 'Middle Aged', 'Retrospective Studies', 'Risk Factors', 'Stroke'] | 14,707,424 | [['M01.060.116.100'], ['A01.378.610.050'], ['C14.907.137.126'], ['A07.015.114.139'], ['C10.228.140.300.150', 'C14.907.253.092'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.525', 'E05.318.740.600.800.450', 'E05.318.740.750.450', 'E05.599.835.875', 'N05.715.360.750.530.480', 'N05.715.360.750.625.7... | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Interleukin-8 production by human peritoneal mesothelial cells in response to tumor necrosis factor-alpha, interleukin-1, and medium conditioned by macrophages cocultured with Staphylococcus epidermidis. | Patients treated with continuous ambulatory peritoneal dialysis (CAPD) may suffer from recurrent peritonitis episodes caused by Staphylococcus epidermidis. Early recruitment of granulocytes from the peripheral blood is important for the peritoneal antibacterial defense of CAPD patients. In this study, human peritoneal ... | ['Cells, Cultured', 'Chemotaxis, Leukocyte', 'Culture Media, Conditioned', 'Cytokines', 'Humans', 'Interleukin-1', 'Interleukin-8', 'Macrophages, Peritoneal', 'Peritoneum', 'Phagocytosis', 'Staphylococcus epidermidis', 'Tumor Cells, Cultured', 'Tumor Necrosis Factor-alpha'] | 8,228,354 | [['A11.251'], ['G04.198.424.233'], ['D27.720.470.305.250', 'E07.206.250'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.465.010', 'D12.644.276.374.500.400', 'D12.776.467.374.465.010', 'D12.776.467.374.500.400', 'D23.529.374.465.131', 'D23.529.... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Two-dimensional 1H, 15N NMR investigation of uniformly 15N-labeled lac repressor headpiece. | 15N uniformly labeled lac repressor and lac repressor headpiece were prepared. 15N NMR spectra of lac repressor were shown resolution inadequate for detailed study while the data showed that the 15N labeled N-terminal part of the protein is quite suitable for this type of study allowing future investigation of the spec... | ['Amino Acid Sequence', 'Magnetic Resonance Spectroscopy', 'Molecular Sequence Data', 'Protein Conformation', 'Repressor Proteins'] | 1,524,707 | [['G02.111.570.060', 'L01.453.245.667.060'], ['E05.196.867.519'], ['L01.453.245.667'], ['G02.111.570.820.709'], ['D12.776.260.703', 'D12.776.930.780']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
NMDA receptor binding in focal epilepsies. | OBJECTIVE: To demonstrate altered N-methyl-d-aspartate (NMDA) receptor availability in patients with focal epilepsies using positron emission tomography (PET) and [(18)F]GE-179, a ligand that selectively binds to the open NMDA receptor ion channel, which is thought to be overactive in epilepsy.METHODS: Eleven patients ... | ['Adult', 'Antidepressive Agents', 'Brain Mapping', 'Carbazoles', 'Cross-Sectional Studies', 'Drug Interactions', 'Drug Resistant Epilepsy', 'Electroencephalography', 'Epilepsies, Partial', 'Female', 'Humans', 'Male', 'Middle Aged', 'Radionuclide Imaging', 'Radiopharmaceuticals', 'Receptors, N-Methyl-D-Aspartate', 'You... | 25,991,402 | [['M01.060.116'], ['D27.505.954.427.700.122'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['D03.633.100.473.144', 'D03.633.300.148'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['G07.690.773.968'], ['C10.228.140.490.125'], ['E01.370.376.300', 'E01.370.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Increased risk of pyogenic liver abscess in patients with alcohol intoxication: A population-based retrospective cohort study. | We designed a population-based retrospective cohort study to investigate the association between the event of alcohol intoxication and the risk of pyogenic liver abscess. The present study enrolled 245,076 patients with a history of alcohol intoxication from 2000 to 2010 and matched each of them with four comparison pa... | ['Adult', 'Alcoholic Intoxication', 'Cohort Studies', 'Female', 'Follow-Up Studies', 'Humans', 'Liver Abscess, Pyogenic', 'Male', 'Middle Aged', 'Population Surveillance', 'Retrospective Studies', 'Risk Factors', 'Taiwan', 'Young Adult'] | 28,965,652 | [['M01.060.116'], ['C25.775.100.175', 'F03.900.100.300'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C01.830.025.020.455.730', 'C06.552.597.75... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Chondromodulin-I expression in the growth plate of young uremic rats. | BACKGROUND: Growth retardation of chronic renal failure is associated with alterations in the growth plate suggestive of a disturbed chondrocyte maturation process and abnormal vascular invasion at the chondro-osseous interphase. Chondromodulin I (ChM-I) is a potent cartilage-specific angiostatic factor. Its pattern of... | ['Animal Nutritional Physiological Phenomena', 'Animals', 'Cell Division', 'Chondrocytes', 'Female', 'Growth', 'Growth Plate', 'Immunohistochemistry', 'Intercellular Signaling Peptides and Proteins', 'Kidney', 'Membrane Proteins', 'RNA, Messenger', 'Rats', 'Rats, Sprague-Dawley', 'Reverse Transcriptase Polymerase Chain... | 15,200,412 | [['G07.203.650.161'], ['B01.050'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.329.171'], ['G07.345.249'], ['A02.835.232.251.352'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512', 'H01.158.... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Lynch syndrome-associated breast cancers: clinicopathologic characteristics of a case series from the colon cancer family registry. | PURPOSE: The recognition of breast cancer as a spectrum tumor in Lynch syndrome remains controversial. The aim of this study was to explore features of breast cancers arising in Lynch syndrome families.EXPERIMENTAL DESIGN: This observational study involved 107 cases of breast cancer identified from the Colorectal Cance... | ['Adult', 'Aged', 'Aged, 80 and over', 'Breast Neoplasms', 'Breast Neoplasms, Male', 'Carcinoma', 'Case-Control Studies', 'Colonic Neoplasms', 'Colorectal Neoplasms, Hereditary Nonpolyposis', 'DNA Mismatch Repair', 'Family', 'Female', 'Genetic Carrier Screening', 'Genetic Predisposition to Disease', 'Humans', 'Male', '... | 20,215,533 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C04.588.180', 'C17.800.090.500'], ['C04.588.180.260', 'C17.800.090.500.260'], ['C04.557.470.200'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['C04.588.274.476.411.307.180', 'C06.301.371.411.307.180', 'C06.405.249.411.... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Fragmentation of protonated 2-(2-phenylethyl)chromones from agarwood: the diagnostic role of ion/neutral complexes as reactive intermediates. | A positive-ion electrospray ionisation collision-induced dissociation mass spectrometric study on the fragmentation of the [M + H](+) ions of 2-(2-phenylethyl)chromone and a set of nine hydroxyl- and/or methoxy-substituted derivatives has revealed a highly prominent fragmentation channel, the loss of benzoquinomethanes... | ['Flavonoids', 'Ions', 'Models, Chemical', 'Models, Molecular', 'Protons', 'Spectrometry, Mass, Electrospray Ionization', 'Wood'] | 26,307,740 | [['D03.383.663.283.266.450', 'D03.633.100.150.266.450'], ['D01.248.497'], ['E05.599.495'], ['E05.599.595'], ['D01.248.497.300.459.700', 'D01.268.406.750', 'D01.362.340.750', 'G01.249.660.500'], ['E05.196.566.600'], ['A18.450.500.500', 'J01.637.241.900']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]'] | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Clinical Performance of One-Piece, Screw-Retained Implant Crowns Based on Hand-Veneered CAD/CAM Zirconia Abutments After a Mean Follow-up Period of 2.3 Years. | PURPOSE: The aim of this study was to evaluate the clinical performance of one-piece, screw-retained implant crowns based on hand-veneered computer-aided design/computer-aided manufacture (CAD/CAM) zirconium dioxide abutments with a crossfit connection at least 1 year after insertion of the crown.MATERIALS AND METHODS:... | ['Adult', 'Aged', 'Aged, 80 and over', 'Bone Screws', 'Computer-Aided Design', 'Crowns', 'Dental Abutments', 'Dental Implant-Abutment Design', 'Dental Prosthesis, Implant-Supported', 'Esthetics, Dental', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Middle Aged', 'Young Adult', 'Zirconium'] | 29,340,353 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E07.695.370.437', 'E07.858.442.660.460.437', 'E07.858.690.725.460.437'], ['L01.224.108.150', 'L01.296.110.150'], ['E06.780.346.250', 'E07.695.190.088'], ['E06.780.346.500', 'E07.695.190.175'], ['E06.780.346.625.500', 'E06.912.145.750'], ['E06.780.346.706... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Leap-dynamics: efficient sampling of conformational space of proteins and peptides in solution. | A molecular simulation scheme, called Leap-dynamics, that provides efficient sampling of protein conformational space in solution is presented. The scheme is a combined approach using a fast sampling method, imposing conformational 'leaps' to force the system over energy barriers, and molecular dynamics (MD) for refine... | ['Alanine', 'Amino Acid Substitution', 'Animals', 'Aprotinin', 'Cattle', 'Computer Simulation', 'Dipeptides', 'Models, Molecular', 'Motion', 'Pliability', 'Protein Conformation', 'Solutions', 'Solvents', 'Thermodynamics', 'Water'] | 10,745,078 | [['D12.125.042'], ['E05.393.420.601.035', 'G05.558.109'], ['B01.050'], ['D12.776.083'], ['B01.050.150.900.649.313.500.380.271'], ['L01.224.160'], ['D12.644.456.345'], ['E05.599.595'], ['G01.482'], ['G01.374.705'], ['G02.111.570.820.709'], ['D26.776'], ['D27.720.844'], ['G01.906'], ['D01.045.250.875', 'D01.248.497.158.4... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Information Science [L]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Atherosclerotic plaque metabolism in high cardiovascular risk subjects - A subclinical atherosclerosis imaging study with 18 | BACKGROUND AND AIMS: Atherosclerotic plaque molecular imaging with 18F-sodium fluoride (NaF) in positron emission tomography with computed tomography (PET-CT) provides potential discrimination between active unstable microcalcification and established dormant calcification. We aimed to study 18F-NaF atherosclerotic pla... | ['Adult', 'Calcinosis', 'Cardiovascular Diseases', 'Disease Progression', 'Female', 'Fluorodeoxyglucose F18', 'Humans', 'Male', 'Middle Aged', 'Molecular Imaging', 'Plaque, Atherosclerotic', 'Portugal', 'Positron Emission Tomography Computed Tomography', 'Predictive Value of Tests', 'Prevalence', 'Prospective Studies',... | 28,349,887 | [['M01.060.116'], ['C18.452.174.130'], ['C14'], ['C23.550.291.656'], ['D09.254.229.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.370.350.557', 'E05.601.555'], ['C23.300.823'], ['Z01.542.727'], ['E01.370.350.350.800.700.500', 'E01.370.350.350.810.645', 'E01.370.350.567.500', 'E01.370... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Thermosensitive hexanoyl glycol chitosan-based ocular delivery system for glaucoma therapy. | UNLABELLED: Conventional eye drops quickly move away from the surface of the eye; as a result, ocular bioavailability is very limited. To overcome this issue, we developed a thermosensitive hexanoyl glycol chitosan (HGC) as a carrier for topical drug delivery to the eye. Here, we modulated the degree of N-hexanoylation... | ['Administration, Ophthalmic', 'Animals', 'Brimonidine Tartrate', 'Delayed-Action Preparations', 'Glaucoma', 'Glycols', 'Hot Temperature', 'Male', 'Rabbits'] | 27,163,401 | [['E02.319.267.120.805'], ['B01.050'], ['D03.633.100.857.070'], ['D26.255.210', 'E02.319.300.253'], ['C11.525.381'], ['D02.033.455'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.775.710.380', 'N06.230.300.100.725.232', 'N06.230.300.100.725.710.380'], ['B01.050.150.900.649.313.968.700']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Hypothalamic hamartomas: seven cases and review of the literature. | Hypothalamic hamartomas constitute rare developmental lesions associated with gelastic epilepsy and/or precocious puberty (PP). We elected to review cases encountered at our center (7 patients) and the existing literature (277 patients) to obtain a better understanding of the clinical aspects, pathogenesis, and treatme... | ['Adolescent', 'Adult', 'Anticonvulsants', 'Brain Diseases', 'Cognition Disorders', 'Electroencephalography', 'Epilepsies, Partial', 'Female', 'Growth Hormone-Releasing Hormone', 'Hamartoma', 'Humans', 'Hypothalamus', 'Magnetic Resonance Imaging', 'Male', 'Neurosurgical Procedures', 'Puberty, Precocious', 'Radiosurgery... | 12,791,326 | [['M01.060.057'], ['M01.060.116'], ['D27.505.954.427.080'], ['C10.228.140'], ['F03.615.250'], ['E01.370.376.300', 'E01.370.405.245'], ['C10.228.140.490.360'], ['D06.472.699.327.740.860', 'D12.644.400.400.740.860', 'D12.644.548.365.740.860', 'D12.776.631.650.405.740.860'], ['C04.445'], ['B01.050.150.900.649.313.988.400.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Demography of an apex predator at the edge of its range: impacts of changing sea ice on polar bears in Hudson Bay. | Changes in the abundance and distribution of wildlife populations are common consequences of historic and contemporary climate change. Some Arctic marine mammals, such as the polar bear (Ursus maritimus), may be particularly vulnerable to such changes due to the loss of Arctic sea ice. We evaluated the impacts of envir... | ['Animals', 'Arctic Regions', 'Bays', 'Climate Change', 'Ecosystem', 'Female', 'Ice Cover', 'Male', 'Models, Biological', 'Population Dynamics', 'Time Factors', 'Ursidae'] | 27,755,745 | [['B01.050'], ['Z01.208'], ['G01.311.625.080'], ['G16.500.175.374'], ['G16.500.275.157', 'N06.230.124'], ['G01.311.400', 'G16.500.275.410.500', 'N06.230.291.500'], ['E05.599.395'], ['I01.240.600', 'N01.224.625', 'N06.850.505.400.700'], ['G01.910.857'], ['B01.050.150.900.649.313.750.250.761']] | ['Organisms [B]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
[Prostate cancer, antiandrogen treatment and cardiovascular risk]. | AIM: To assess if cardiovascular risk (CVR) charts are able to identify the increased risk caused by androgen deprivation therapy (ADT) in patients with prostate cancer (PCa).DESIGN: Retrospective cohort study.LOCATION: Urban and rural health centres in the province of Ourense.PARTICIPANTS: Patients diagnosed with PCa ... | ['Aged', 'Aged, 80 and over', 'Androgen Antagonists', 'Cardiovascular Diseases', 'Cohort Studies', 'Humans', 'Male', 'Middle Aged', 'Prostatic Neoplasms', 'Retrospective Studies', 'Risk Assessment', 'Risk Factors'] | 21,211,867 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['D06.347.065', 'D27.505.696.399.450.065'], ['C14'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C04.588.945.440.770', 'C12.294.260.750', 'C12.294.565.625', 'C12.758.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
FGF21-FGFR1 Coordinates Phospholipid Homeostasis, Lipid Droplet Function, and ER Stress in Obesity. | The antiobese and antidiabetic fibroblast growth factor 21 (FGF21) regulates lipid metabolism and energy homeostasis by targeting the âKlotho-FGFR1 (fibroblast growth factor receptor 1) binary complex in adipose tissue adipocytes. Because lipid droplet is the organelle responsible for storing lipid energy in adipocytes... | ['Adipocytes', 'Adipose Tissue', 'Animals', 'Endoplasmic Reticulum Stress', 'Energy Metabolism', 'Fibroblast Growth Factors', 'Homeostasis', 'Lipid Droplets', 'Lipid Metabolism', 'Liver', 'Membrane Proteins', 'Mice', 'Mice, Knockout', 'Obesity', 'Phospholipids', 'Receptor, Fibroblast Growth Factor, Type 1', 'Signal Tra... | 27,690,692 | [['A11.329.114'], ['A10.165.114'], ['B01.050'], ['G04.434'], ['G03.295'], ['D12.644.276.624', 'D12.776.467.624', 'D23.529.624'], ['G07.410'], ['A11.284.430.214.190.875.393'], ['G03.458'], ['A03.620'], ['D12.776.543'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.136.500.500', 'B01.050.150.900.649.313.992.... | ['Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Classification of wines from five Spanish origin denominations by aromatic compound analysis. | Wine is a complex matrix in which aroma compounds play an important role in the characterization of the flavor pattern of a given wine. Twelve volatile compounds were determined in 244 samples of Spanish red wines from different denominations of origin: Rioja, Navarra, Valdepe?as, La Mancha, and Cari?ena. The samples w... | ['Calibration', 'Chromatography, Gas', 'Discriminant Analysis', 'Geography', 'Hydrocarbons, Aromatic', 'Indicators and Reagents', 'Mass Spectrometry', 'Principal Component Analysis', 'Software', 'Solid Phase Microextraction', 'Spain', 'Wine'] | 21,313,821 | [['E05.978.155'], ['E05.196.181.349'], ['E05.318.740.350', 'N05.715.360.750.325', 'N06.850.520.830.350'], ['H01.277.500'], ['D02.455.426.559'], ['D27.720.470.410'], ['E05.196.566'], ['E05.318.740.562'], ['L01.224.900'], ['E05.196.155.800.500'], ['Z01.542.846'], ['G07.203.100.100.900', 'G07.203.200.887', 'J02.200.100.90... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Information Science [L]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 |
Drosophila Histone Demethylase KDM5 Regulates Social Behavior through Immune Control and Gut Microbiota Maintenance. | Loss-of-function mutations in the histone demethylases KDM5A, KDM5B, or KDM5C are found in intellectual disability (ID) and autism spectrum disorders (ASD) patients. Here, we use the model organism Drosophila melanogaster to delineate how KDM5 contributes to ID and ASD. We show that reducing KDM5 causes intestinal barr... | ['Animals', 'Autism Spectrum Disorder', 'Behavior, Animal', 'Disease Models, Animal', 'Drosophila', 'Drosophila Proteins', 'Drosophila melanogaster', 'Female', 'Gastrointestinal Microbiome', 'Histone Demethylases', 'Humans', 'Intestinal Mucosa', 'Male', 'Social Behavior'] | 30,902,578 | [['B01.050'], ['F03.625.164.113'], ['F01.145.113'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['B01.050.500.131.617.720.500.500.750.310.250'], ['D12.776.093.500.462'], ['B01.050.500.131.617.720.500.500.750.310.250.500'], ['G06.591.375', 'G16.500.275.157.049.100.500.375', 'N06.230.124.049.100.500.250'], ['D08.811.6... | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Donated ovarian tissue in embryo research and assisted conception--the view of women of reproductive age. | In response to widespread interest by the media, the Human Fertilisation and Embryology Authority (HFEA) recently produced a document entitled 'Donated Ovarian Tissue in Embryology Research and Assisted Conception'. Interested organizations and the public were asked for their views on the use of eggs or ovarian tissue ... | ['Aborted Fetus', 'Adolescent', 'Adult', 'Aged', 'Cadaver', 'Embryo Research', 'Embryology', 'Ethics, Medical', 'Female', 'Fetal Tissue Transplantation', 'Government Regulation', 'Human Experimentation', 'Humans', 'Middle Aged', 'Oocyte Donation', 'Pregnant Women', 'Public Opinion', 'Reproductive Techniques', 'Research... | 7,657,774 | [['A16.378.099'], ['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['C23.550.260.224'], ['E05.313', 'H01.770.644.145.250'], ['H01.158.100.529', 'H01.158.273.200.350'], ['K01.752.566.479.171.132.750', 'N05.350.340.162.500'], ['E02.095.147.725.300', 'E04.936.580.300'], ['I01.880.604.394', 'N03.706.358'], ['E05.445'... | ['Anatomy [A]', 'Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Humanities [K]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 |
A new colimetric assay for monoamine oxidase in serum and its clinical application. | A new colimetric assay for serum monoamine oxidase and clinical findings based on this method are described. This rapid, precise procedure employs 1-[(4-aminomethylphenyl)azol]-2-naphthol as a substrate. The enzymatically generated 1-[(4-formyl phenyl)azo]-2-naphthol is extracted into cyclohexane to form a colored solu... | ['Aldehydes', 'Animals', 'Buffers', 'Cattle', 'Colorimetry', 'Diabetes Mellitus', 'Electrophoresis, Agar Gel', 'Female', 'Heart Diseases', 'Hepatitis', 'Humans', 'Hydrogen-Ion Concentration', 'In Vitro Techniques', 'Kidney Diseases', 'Liver Cirrhosis', 'Male', 'Monoamine Oxidase', 'Naphthols', 'Oxygen Consumption', 'Th... | 237,053 | [['D02.047'], ['B01.050'], ['D27.720.470.280'], ['B01.050.150.900.649.313.500.380.271'], ['E05.196.922.250'], ['C18.452.394.750', 'C19.246'], ['E05.196.401.153', 'E05.301.300.100'], ['C14.280'], ['C06.552.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.300'], ['E05.481'], ['C12.777.419', 'C13.351.968.419'... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Therapeutic approaches to the treatment of hairy cell leukemia. | Although a rare disease, hairy cell leukemia has great biologic and clinical significance. New therapeutic options of alpha-interferon and pentostatin have challenged the role of splenectomy in the overall management of the disease. alpha-Interferon can now be considered the treatment of choice for patients who progres... | ['Antineoplastic Agents', 'Antineoplastic Combined Chemotherapy Protocols', 'Bone Marrow Transplantation', 'Coformycin', 'Humans', 'Interferon Type I', 'Leukapheresis', 'Leukemia, Hairy Cell', 'Pentostatin', 'Recombinant Proteins', 'Splenectomy'] | 3,541,219 | [['D27.505.954.248'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['E02.095.147.725.040', 'E04.936.580.040'], ['D03.383.742.680.350.200', 'D13.570.685.350.200', 'D13.570.800.410.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.440.890', 'D12.776.467.374.440.890', 'D23.529.374.440... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Binding of 3H-diazepam by cerebral cortex synaptic membranes in the rat during conditioned reflex elaboration]. | In-vitro experiments were made to compare specific binding of 3H-diazepam with synaptic membranes obtained from the large hemispheres of rats trained the defense conditioned reflex to that in rats exposed to non-combined stimuli (active control). Within the concentration range of 0.37 nM-30 nM, specific binding of 3H-d... | ['Animals', 'Avoidance Learning', 'Cerebral Cortex', 'Conditioning, Classical', 'Diazepam', 'Electroshock', 'In Vitro Techniques', 'Light', 'Male', 'Rats', 'Synaptic Membranes'] | 7,326,418 | [['B01.050'], ['F02.463.425.097', 'F02.463.785.373.173'], ['A08.186.211.200.885.287.500'], ['F02.463.425.179.308'], ['D03.633.100.079.080.070.216'], ['E05.723.402.403', 'F04.669.224'], ['E05.481'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['B01.050.150.900.649.313.992.635.505.700'],... | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Flagellar quiescence response in sea urchin sperm induced by electric stimulation. | To investigate the mechanism of the flagellar quiescence in sperm, we examined the effect of electric stimulation of individual spermatozoa of the sea urchin, Hemicentrotus pulcherrimus. Stimulation with a suction electrode attached to the sperm head elicited a flagellar quiescence response, in which the sperm showed a... | ['Animals', 'Calcium', 'Electric Stimulation', 'Electrodes', 'Electrophysiology', 'Male', 'Membrane Potentials', 'Sea Urchins', 'Sperm Motility', 'Sperm Tail'] | 7,553,902 | [['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['E05.723.402'], ['E07.305.250'], ['H01.158.344.528', 'H01.158.782.236'], ['G01.154.535', 'G04.580', 'G07.265.675', 'G11.561.570'], ['B01.050.500.408.578'], ['E01.370.225.992.812', 'E05.200.992.812', 'G04.198.750'], ['A05.360.490.890.840', 'A11.284.18... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Relative genotoxic activities of pesticides evaluated by a modified SOS microplate assay. | The genotoxic activities of 47 pesticides were determined using a modified SOS microplate assay in which the induction of beta-galactosidase in E. coli PQ37 was used as a quantitative measure of genotoxic activity. The results were compared with those obtained with anethole, curcumin, and capsaicin, a few examples of n... | ['DNA Damage', 'Escherichia coli', 'Micelles', 'Mutagenicity Tests', 'Pesticides', 'SOS Response, Genetics', 'beta-Galactosidase'] | 7,875,128 | [['G05.200'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D05.374', 'D26.255.560'], ['E05.393.560', 'E05.940.560'], ['D27.720.031.700', 'D27.888.723'], ['G02.111.222.830', 'G05.219.830'], ['D08.811.277.450.410.100']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Acquiring English at different ages: the English displacement effect and other findings. | An analysis of the language backgrounds of 237 persons in a psychology department subject pool is presented. Specific findings indicate that (a) only about two-thirds of the subjects were native speakers of English, (b) native English speakers can be divided into several different groups on the basis of bilingual backg... | ['Adolescent', 'Adult', 'Child', 'Child, Preschool', 'Humans', 'Language', 'Language Development', 'Memory', 'Mental Recall', 'Semantics'] | 2,374,106 | [['M01.060.057'], ['M01.060.116'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.209.399', 'L01.559'], ['F01.525.200.310'], ['F02.463.425.540'], ['F02.463.425.540.641'], ['L01.559.598.745']] | ['Named Groups [M]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
A genome-wide screen for linkage in Nordic sib-pairs with multiple sclerosis. | Genetic factors influence susceptibility to multiple sclerosis but the responsible genes remain largely undefined, association with MHC class II alleles being the only established genetic feature of the disease. The Nordic countries have a high prevalence of multiple sclerosis, and to further explore the genetic backgr... | ['Denmark', 'Female', 'Finland', 'Genes, MHC Class II', 'Genetic Linkage', 'Genetic Markers', 'Genome, Human', 'HLA-DR Antigens', 'HLA-DR Serological Subtypes', 'Humans', 'Lod Score', 'Male', 'Multiple Sclerosis', 'Norway', 'Sweden'] | 12,140,746 | [['Z01.542.816.124'], ['Z01.542.816.186'], ['G05.360.340.024.340.610.600', 'G05.360.340.024.380.500.600', 'G12.500.500.600'], ['G05.348'], ['D23.101.387', 'G05.695.450'], ['G05.360.340.350'], ['D12.776.395.550.509.400.440', 'D12.776.543.550.440.400.440', 'D23.050.301.500.400.400.440', 'D23.050.301.500.450.400.440', 'D2... | ['Geographicals [Z]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Characterizing the binding motifs of 11 common human HLA-DP and HLA-DQ molecules using NNAlign. | Compared with HLA-DR molecules, the specificities of HLA-DP and HLA-DQ molecules have only been studied to a limited extent. The description of the binding motifs has been mostly anecdotal and does not provide a quantitative measure of the importance of each position in the binding core and the relative weight of diffe... | ['Alleles', 'Amino Acid Motifs', 'Binding Sites', 'Computational Biology', 'Databases, Protein', 'HLA-DP Antigens', 'HLA-DQ Antigens', 'Humans', 'Hydrophobic and Hydrophilic Interactions', 'Neural Networks, Computer', 'Sequence Alignment'] | 22,352,343 | [['G05.360.340.024.340.030'], ['G02.111.570.820.709.275.500', 'G02.111.570.820.709.600.500'], ['G02.111.570.120'], ['H01.158.273.180', 'L01.313.124'], ['L01.313.500.750.300.188.400.300.750', 'L01.313.500.750.300.188.400.325.710', 'L01.470.750.750.300.750', 'L01.470.750.750.325.710'], ['D12.776.395.550.509.400.420', 'D1... | ['Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
BLAST PRINTS--alternative perspectives on sequence similarity. | SUMMARY: An implementation of BLAST for searching the PRINTS database is presented. The interface allows submission of either protein or DNA queries, and returns the familiar form of output, but modified by means of direct links both to the familial discriminators in PRINTS and to fingerprint profile visualization soft... | ['Animals', 'Computational Biology', 'DNA', 'Databases, Factual', 'Evaluation Studies as Topic', 'Humans', 'Proteins', 'Sequence Alignment', 'Software'] | 10,383,477 | [['B01.050'], ['H01.158.273.180', 'L01.313.124'], ['D13.444.308'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['E05.337', 'N05.715.360.335'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776'], ['E05.393.751'], ['L01.224.900']] | ['Organisms [B]', 'Disciplines and Occupations [H]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Occurrence of phthalate esters in sediments in Qiantang River, China and inference with urbanization and river flow regime. | Phthalate esters (PAEs), a group of emerging organic contaminants, have become a serious issue arousing much attention for their ubiquitous presence and hazardous impact on the environment. This study provides the first data on distribution of PAEs in the sediments in the Qiantang River, Zhejiang Province, China, and t... | ['China', 'Environmental Monitoring', 'Geologic Sediments', 'Phthalic Acids', 'Risk Assessment', 'Rivers', 'Urbanization', 'Water Movements', 'Water Pollutants, Chemical'] | 23,339,883 | [['Z01.252.474.164'], ['N06.850.460.350.080', 'N06.850.780.375'], ['G01.311.330', 'G16.500.320'], ['D02.241.223.805'], ['E05.318.740.600.800.715', 'N04.452.871.715', 'N05.715.360.750.625.700.690', 'N06.850.505.715', 'N06.850.520.830.600.800.715'], ['G01.311.750', 'G16.500.275.280.650', 'N06.230.232.650'], ['I01.880.853... | ['Geographicals [Z]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
ChIP-seq and transcriptome analysis of the OmpR regulon of Salmonella enterica serovars Typhi and Typhimurium reveals accessory genes implicated in host colonization. | OmpR is a multifunctional DNA binding regulator with orthologues in many enteric bacteria that exhibits classical regulator activity as well as nucleoid-associated protein-like characteristics. In the enteric pathogen Salmonella enterica, using chromatin immunoprecipitation of OmpR:FLAG and nucleotide sequencing, 43 pu... | ['Animals', 'Binding Sites', 'Cecum', 'Chromatin Immunoprecipitation', 'Colitis', 'DNA, Bacterial', 'Disease Models, Animal', 'Gene Expression Profiling', 'Ileum', 'Mice', 'Regulon', 'Salmonella Infections, Animal', 'Salmonella typhi', 'Salmonella typhimurium', 'Sequence Analysis, DNA', 'Trans-Activators', 'Virulence'] | 23,190,111 | [['B01.050'], ['G02.111.570.120'], ['A03.556.124.526.209', 'A03.556.249.249.209'], ['E05.393.170', 'E05.478.605.160'], ['C06.405.205.265', 'C06.405.469.158.188'], ['D13.444.308.212'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['E05.393.332'], ['A03.556.124.684.249', 'A03.556.249.124'], ['B01.050.150.900.649.313.99... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Preferential looking in the mentally handicapped. | We have assessed the feasibility of Preferential Looking (PL), using Teller Acuity Cards, for the estimation of binocular and monocular visual acuities in a group of mentally handicapped adults. Our results show the comparison between grating and recognition acuities, inter-observer variation, success rate, time taken ... | ['Adult', 'Aged', 'Aged, 80 and over', 'Female', 'Humans', 'Intellectual Disability', 'Male', 'Middle Aged', 'Observer Variation', 'Random Allocation', 'Vision Tests', 'Vision, Binocular', 'Vision, Monocular', 'Visual Acuity'] | 2,630,367 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.597.606.360', 'C23.888.592.604.646', 'F01.700.687', 'F03.625.539'], ['M01.060.116.630'], ['E01.354.753', 'N02.421.450.600', 'N05.715.350.150.675', 'N06.850.490.500.250'], ['E05.318.370.700', 'E05.581.5... | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
NF-ê B-dependent upregulation of ICAM-1 by HPV16-E6/E7 facilitates NK cell/target cell interaction. | NK cell recognition of tumor cells is mediated by a delicate balance of signals received by MHC class I-binding inhibitory NK cell receptors and activating NK cell receptors, which mainly bind to virus-, stress- or tumor-induced ligands. In addition, adhesion molecules such as the intercellular adhesion molecule-1 (ICA... | ['Base Sequence', 'Blotting, Western', 'Cells, Cultured', 'DNA Primers', 'Enzyme-Linked Immunosorbent Assay', 'Flow Cytometry', 'Humans', 'Intercellular Adhesion Molecule-1', 'Keratinocytes', 'NF-kappa B', 'Oncogene Proteins, Viral', 'Papillomavirus E7 Proteins', 'Repressor Proteins', 'Reverse Transcriptase Polymerase ... | 20,473,930 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['A11.251'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Electro-acupuncture-modulated miR-214 prevents neuronal apoptosis by targeting Bax and inhibits sodium channel Nav1.3 expression in rats after spinal cord injury. | Electro-acupuncture (EA) has been proven to contribute towards neurologic and functional recoveries in spinal cord injury (SCI), but the underlying mechanism remains largely unknown especially regarding the effects of preventing neuronal apoptosis and alleviating neuropathic pain involved in the development of EA. In t... | ['Acupuncture', 'Animals', 'Apoptosis', 'Caspase 3', 'Cell Line', 'Disease Models, Animal', 'Down-Regulation', 'Female', 'Mice', 'MicroRNAs', 'NAV1.3 Voltage-Gated Sodium Channel', 'Proto-Oncogene Proteins c-bcl-2', 'Rats', 'Rats, Sprague-Dawley', 'Recovery of Function', 'Spinal Cord', 'Spinal Cord Injuries', 'Up-Regul... | 28,298,073 | [['H02.004'], ['B01.050'], ['G04.146.954.035'], ['D08.811.277.656.262.500.126.350.300', 'D08.811.277.656.300.200.126.350.300', 'D12.644.360.075.405.350.300', 'D12.776.476.075.405.350.300'], ['A11.251.210'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['B01.050.150.9... | ['Disciplines and Occupations [H]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
The regulation of urea amidolyase of Saccharomyces cerevisiae: mating type influence on a constitutivity mutation acting in cis. | Constitutivity for the synthesis of the urea amidolyase bienzymatic complex is obtained by durOh mutations located in the regulatory genetic region adjacent to the dur1, dur2 gene cluster. The durOh mutations act only in cis and are a new case of cis effect strongly cancelled in alpha/a diploid, similar to cargA+Oh mut... | ['Allophanate Hydrolase', 'Amidohydrolases', 'Carbon-Nitrogen Ligases', 'Chromosome Mapping', 'Diploidy', 'Genes, Dominant', 'Genes, Recessive', 'Genes, Regulator', 'Ligases', 'Multienzyme Complexes', 'Mutation', 'Phenotype', 'Saccharomyces cerevisiae', 'Urea'] | 368,577 | [['D08.811.277.087.060'], ['D08.811.277.087'], ['D08.811.464.259'], ['E05.393.183'], ['G05.700.264'], ['G05.360.340.024.340.240', 'G05.420.320'], ['G05.360.340.024.340.415', 'G05.420.325'], ['G05.360.340.024.340.425'], ['D08.811.464'], ['D05.500.562', 'D08.811.600'], ['G05.365.590'], ['G05.695'], ['B01.300.107.795.785.... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
N-trimethyl chitosan nanoparticles and CSKSSDYQC peptide: N-trimethyl chitosan conjugates enhance the oral bioavailability of gemcitabine to treat breast cancer. | Gemcitabine is a nucleoside analogue effective against a number of cancers. However, the full potential of this drug has not been realised, in part due to low oral bioavailability and frequent dosing requirements. This study reports the synthesis, in-vitro, ex-vivo and in-vivo evaluation of trimethyl chitosan (TMC) - C... | ['Administration, Oral', 'Animals', 'Antimetabolites, Antineoplastic', 'Biological Availability', 'Breast Neoplasms', 'Caco-2 Cells', 'Cell Survival', 'Chitosan', 'Deoxycytidine', 'Female', 'HT29 Cells', 'Humans', 'Male', 'Mice', 'Mice, Inbred BALB C', 'Mice, Nude', 'Nanoparticles', 'Peptide Fragments', 'Rats', 'Rats, ... | 29,548,985 | [['E02.319.267.100'], ['B01.050'], ['D27.505.519.186.144', 'D27.505.954.248.144', 'D27.888.569.042.030'], ['G03.787.151', 'G07.690.725.129'], ['C04.588.180', 'C17.800.090.500'], ['A11.251.210.190.160', 'A11.251.860.180.160', 'A11.436.140'], ['G04.346'], ['D05.750.078.139.500', 'D09.698.211.500'], ['D03.383.742.680.245.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Acceleration of growth of cultured cardiomyocytes and translocation of protein kinase C. | Phorbol 12-myristate 13-acetate (PMA), norepinephrine (NE), and contraction stimulate cardiomyocyte growth (increased protein content). Differences exist in the time course and extent of protein and RNA accumulation. Cells plated at 4 x 10(6) cells/60-mm dish and arrested with 50 mM KCl demonstrated no significant grow... | ['Alkaloids', 'Cell Division', 'Cell Nucleus', 'Cells, Cultured', 'Muscle Proteins', 'Myocardial Contraction', 'Myocardium', 'Norepinephrine', 'Protein Kinase C', 'Protein Kinases', 'Staurosporine', 'Tetradecanoylphorbol Acetate', 'Time Factors', 'Translocation, Genetic'] | 1,514,580 | [['D03.132'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['A11.251'], ['D12.776.210.500'], ['G09.330.580', 'G11.427.494.570'], ['A02.633.580', 'A07.541.704', 'A10.690.552.750'], ['D02.033.100.291.502', 'D02.092.063.480', 'D02.092.211.215... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Blastic plasmacytoid dendritic cell neoplasm. | Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare haematological malignancy that originates from the precursors of plasmacytoid dendritic cells. It commonly presents with findings isolated to the skin although it usually progresses to a leukaemic phase. It has a poor prognosis but is curable, particularly ... | ['Adrenal Cortex Hormones', 'Aged', 'Antineoplastic Combined Chemotherapy Protocols', 'Dendritic Cells', 'Fatal Outcome', 'Hematologic Neoplasms', 'Humans', 'Male', 'Skin Neoplasms'] | 23,582,004 | [['D06.472.040'], ['M01.060.116.100'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['A11.066.270', 'A11.436.270', 'A15.382.066.270', 'A15.382.670.260'], ['E05.318.308.985.550.325', 'N01.224.935.698.201', 'N06.850.505.400.975.550.325', 'N06.850.520.308.985.550.325'], ['C04.588.448', 'C15.378.400'], ['B01.... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The relationship of sweat gland count to electrodermal activity. | This study assessed whether greater skin conductance activity at the distal versus medial site (Scerbo, Freedman, Raine, Dawson, & Venables, 1992) is attributable to a greater number of active (open) sweat glands at the distal site. The number of sweat glands was measured using the Palmar Sweat Index (PSI). Twenty-four... | ['Acoustic Stimulation', 'Adult', 'Arousal', 'Attention', 'Female', 'Galvanic Skin Response', 'Humans', 'Male', 'Middle Aged', 'Reference Values', 'Sweat Glands', 'Sweating'] | 8,153,256 | [['E02.037', 'E02.190.888.030', 'E05.723.136'], ['M01.060.116'], ['F02.830.104', 'G11.561.035'], ['F02.830.104.214'], ['E05.796.332', 'F02.830.702.315', 'F04.669.332', 'G07.265.563', 'G13.750.415'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.978.810'], ['A10.336.899', 'A17.815.830'], ['... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Synthesis and antiviral activities of antofine analogues with different C-6 substituent groups. | On the basis of previous structure-activity relationship (SAR) and antiviral mechanism studies, antofine analogues with different substituent groups at the C-6 position targeting tobacco mosaic virus (TMV) RNA were synthesized for the first time. The antofine analogues 1a-8a and 1b-9b were evaluated for their antiviral... | ['Antiviral Agents', 'Indoles', 'Magnetic Resonance Spectroscopy', 'Phenanthrolines', 'RNA, Viral', 'Structure-Activity Relationship', 'Tobacco Mosaic Virus'] | 23,320,928 | [['D27.505.954.122.388'], ['D03.633.100.473'], ['E05.196.867.519'], ['D03.633.300.669'], ['D13.444.735.828'], ['G02.111.830', 'G07.690.773.997'], ['B04.715.464.725.800', 'B04.820.578.844.800']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Breastfeeding self-efficacy among blind mothers. | OBJECTIVE: To evaluate breastfeeding self-efficacy among blind mothers.METHOD: This is a descriptive and exploratory research carried out in Fortaleza-Ceara, with ten blind mothers. Data were collected through an interview with the application of a socioeconomic and obstetric questionnaire and the Breastfeeding Self-Ef... | ['Adult', 'Breast Feeding', 'Female', 'Humans', 'Mothers', 'Postpartum Period', 'Pregnancy', 'Self Efficacy', 'Surveys and Questionnaires', 'Visually Impaired Persons'] | 30,517,400 | [['M01.060.116'], ['F01.145.407.199', 'G07.203.650.195', 'G07.203.650.220.500.500', 'G07.203.650.353.199'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.263.500.320.200', 'I01.880.853.150.500.340.270', 'M01.620.630'], ['G08.686.702'], ['G08.686.784.769'], ['F01.752.747.792.700'], ['E05.318.308.980', 'N05.... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
The influence of androgen deprivation therapy on metabolism in patients with prostate cancer. | The effects of androgen deprivation therapy (ADT) include not only suppression of tumor growth, but also adverse effects on various bodily functions. The aim of this study was to determine the metabolic effects of ADT in patients with nonmetastatic prostate cancer. Forty-nine men with prostate cancer were treated with ... | ['Absorptiometry, Photon', 'Aged', 'Aged, 80 and over', 'Androgen Antagonists', 'Blood Glucose', 'Blood Urea Nitrogen', 'Body Weight', 'Cholesterol', 'Erythrocyte Count', 'Flutamide', 'Humans', 'Male', 'Middle Aged', 'Neoplasm Staging', 'Orchiectomy', 'Prostatic Neoplasms'] | 15,562,007 | [['E01.370.350.700.024', 'E05.196.712.224.187'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D06.347.065', 'D27.505.696.399.450.065'], ['D09.947.875.359.448.500'], ['E01.370.225.124.100.115', 'E01.370.390.400.100', 'E05.200.124.100.115'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.10... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Sublethal copper toxicity and food response in the freshwater crayfish Cambarus bartonii (Cambaridae, Decapoda, Crustacea). | Food response preceding and following exposure to Cu concentrations of 0.00, 0.02, and 0.2 mg/L was observed in male and female Cambarus bartonii from an uncontaminated, freshwater lake. The animals were tested in a Y-maze. Control animals demonstrated food localization, and the treated animals, either no localization ... | ['Animals', 'Astacoidea', 'Copper', 'Dose-Response Relationship, Drug', 'Feeding Behavior', 'Female', 'Male', 'Time Factors'] | 10,903,830 | [['B01.050'], ['B01.050.500.131.365.190.070'], ['D01.268.556.195', 'D01.268.956.170', 'D01.552.544.195'], ['G07.690.773.875', 'G07.690.936.500'], ['F01.145.113.547', 'F01.145.407', 'G07.203.650.353'], ['G01.910.857']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Identification and validation of a novel cell-recognition site (KNEED) on the 8th type III domain of fibronectin. | Interactions between cell-surface integrins and extracellular matrix proteins underlie a versatile recognition system providing cells with anchorage, traction for migration or matrix remodeling, as well as signals for polarity, differentiation and growth. Short peptide sequences of fibronectin (FN), most notably RGD fo... | ['3T3 Cells', 'Amino Acid Sequence', 'Animals', 'Binding Sites', 'Biocompatible Materials', 'Cell Adhesion', 'Cell Differentiation', 'Cell Division', 'Cell Movement', 'Cells, Cultured', 'Dose-Response Relationship, Drug', 'Extracellular Matrix', 'Fibroblasts', 'Fibronectins', 'Mice', 'Mice, Inbred BALB C', 'Microscopy,... | 12,164,191 | [['A11.251.210.100', 'A11.329.228.100'], ['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.120'], ['D25.130', 'D27.720.102.130', 'J01.637.051.130'], ['G04.022'], ['G04.152'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['G04.198', 'G07.568.500.180'], ['A11.251'], ['G07... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
The psychosocial difficulties in brain disorders that explain short term changes in health outcomes. | BACKGROUND: This study identifies a set of psychosocial difficulties that are associated with short term changes in health outcomes across a heterogeneous set of brain disorders, neurological and psychiatric.METHODS: Longitudinal observational study over approximately 12 weeks with three time points of assessment and 7... | ['Activities of Daily Living', 'Adult', 'Aged', 'Bipolar Disorder', 'Brain Diseases', 'Brain Injuries', 'Depressive Disorder', 'Disability Evaluation', 'Disabled Persons', 'Emotions', 'Female', 'Humans', 'Longitudinal Studies', 'Male', 'Middle Aged', 'Migraine Disorders', 'Mood Disorders', 'Multiple Sclerosis', 'Parkin... | 23,497,332 | [['E02.760.169.063.500.067', 'E02.831.067', 'I03.050', 'N02.421.784.110'], ['M01.060.116'], ['M01.060.116.100'], ['F03.084.500'], ['C10.228.140'], ['C10.228.140.199', 'C10.900.300.087', 'C26.915.300.200'], ['F03.600.300'], ['E01.370.400'], ['M01.150'], ['F01.470'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Organisms [B]', 'Humanities [K]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
[Macroadenoma of the pituitary gland with moderate hyperprolactinaemia]. | HISTORY AND CLINICAL FINDINGS: A 46-year-old woman was referred to the neurosurgery department for treatment of a macroadenoma of the pituitary. She had complained of recurrent galactorrhoea for 7 years; a hysterectomy was performed 4 years ago. The clinical investigation was unremarkable, except for a slight galactorr... | ['Cabergoline', 'Diagnosis, Differential', 'Ergolines', 'Female', 'Follow-Up Studies', 'Humans', 'Hyperprolactinemia', 'Magnetic Resonance Imaging', 'Middle Aged', 'Neoplasm, Residual', 'Pituitary Gland', 'Pituitary Neoplasms', 'Postoperative Complications', 'Prolactinoma'] | 12,660,899 | [['D03.132.327.287.131', 'D03.633.400.439.197'], ['E01.171'], ['D03.132.327.287', 'D03.633.400.439'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.228.140.617.738.250.450', 'C19.700.355.600'], ['E01.370.350.825.500'], [... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Named Groups [M]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Fasciola hepatica tegumental antigens induce anergic-like T cells via dendritic cells in a mannose receptor-dependent manner. | FoxP3(+) Treg cells and anergic T cells are the two regulatory phenotypes of T-cell responses associated with helminth infection. Here, we examine the T-cell responses in mice during Fasciola hepatica infection, and to its tegumental coat antigens (FhTeg) that are shed from the fluke every 2-3 h. FhTeg comprises a rich... | ['Animals', 'Antigens, Helminth', 'Biomarkers', 'CD4-Positive T-Lymphocytes', 'Clonal Anergy', 'Cytokines', 'Dendritic Cells', 'Early Growth Response Protein 2', 'Fasciola hepatica', 'Host-Pathogen Interactions', 'Inducible T-Cell Co-Stimulator Protein', 'Lectins, C-Type', 'Mannose-Binding Lectins', 'Mice', 'Mice, Inbr... | 26,931,640 | [['B01.050'], ['D23.050.223'], ['D23.101'], ['A11.118.637.555.567.569.200', 'A15.145.229.637.555.567.569.200', 'A15.382.490.555.567.569.200'], ['G12.535.425.100'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['A11.066.270', 'A11.436.270', 'A15.382.066.270', 'A15.382.670.260'], ['D12.776.260.158.750', 'D12.77... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Thyroid Hormone Signaling Pathways: Time for a More Precise Nomenclature. | Current literature makes a distinction between two pathways for thyroid hormone signaling: genomic and nongenomic. However, this classification is a source of confusion. We propose a clarification in the nomenclature that may help to avoid unproductive controversies and favor progress in this field of research. Four ty... | ['Animals', 'DNA', 'Humans', 'Receptors, Thyroid Hormone', 'Signal Transduction', 'Terminology as Topic', 'Thyroid Hormones', 'Transcription Factors'] | 28,472,304 | [['B01.050'], ['D13.444.308'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.624.664.700.830', 'D12.776.826.850'], ['G02.111.820', 'G04.835'], ['L01.559.598.400'], ['D06.472.931'], ['D12.776.930']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Pharmacokinetics and safety of olmesartan medoxomil in combination with either amlodipine or atenolol compared to respective monotherapies in healthy subjects. | The aim of this study was to investigate any influence on olmesartan plasma pharmacokinetics from amlodipine or atenolol. We analysed pharmacokinetics and safety of olmesartan medoxomil in combination with either amlodipine or atenolol compared to respective monotherapies in two separate studies. In one study, 18 subje... | ['Adrenergic beta-Antagonists', 'Adult', 'Amlodipine', 'Angiotensin II Type 1 Receptor Blockers', 'Area Under Curve', 'Atenolol', 'Calcium Channel Blockers', 'Cross-Over Studies', 'Drug Interactions', 'Drug Therapy, Combination', 'Humans', 'Imidazoles', 'Male', 'Olmesartan Medoxomil', 'Tetrazoles', 'Therapeutic Equival... | 19,659,504 | [['D27.505.519.625.050.200.200', 'D27.505.696.577.050.200.200'], ['M01.060.116'], ['D03.383.725.203.065'], ['D27.505.519.162.500'], ['E05.318.740.200', 'G03.787.101', 'G07.690.725.064', 'N06.850.520.830.200'], ['D02.033.100.624.698.070', 'D02.033.755.624.698.070', 'D02.092.063.624.698.070'], ['D27.505.519.562.249', 'D2... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Budd-Chiari syndrome. | UNLABELLED: A 16-year-old Ethiopian male patient presented with 18 months history of anasarca, anemia & hepatomegaly associated with hypoprothrombinemia, and diagnosed to have Budd-Chiari syndrome (BCS). The patient responded markedly to medical therapy with diuretics, anticoagulation and salt restriction. The clinical... | ['Adolescent', 'Anticoagulants', 'Budd-Chiari Syndrome', 'Combined Modality Therapy', 'Diagnosis, Differential', 'Female', 'Hepatomegaly', 'Humans', 'Male', 'Sodium Chloride', 'Treatment Outcome', 'Ultrasonography, Doppler', 'Vena Cava, Inferior'] | 20,608,021 | [['M01.060.057'], ['D27.505.954.502.119'], ['C06.552.347', 'C14.907.355.830.925.275'], ['E02.186'], ['E01.171'], ['C06.552.416', 'C23.300.775.525'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.210.450.150.875', 'D01.857.650'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800'], ['E01.370.350.8... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Rapidly increasing incidence of eosinophilic esophagitis in a large cohort. | BACKGROUND: Recent literature has shown increasing incidence and prevalence rates of eosinophilic esophagitis (EoE). However, data are mainly based on small studies and come from centers dedicated to EoE. Aim of this study was to estimate the incidence rates of EoE by using a large database.METHODS: We performed a cros... | ['Adolescent', 'Adult', 'Age Distribution', 'Aged', 'Aged, 80 and over', 'Child', 'Child, Preschool', 'Cohort Studies', 'Cross-Sectional Studies', 'Eosinophilic Esophagitis', 'Female', 'Humans', 'Incidence', 'Infant', 'Infant, Newborn', 'Male', 'Middle Aged', 'Netherlands', 'Sex Distribution', 'Young Adult'] | 22,963,642 | [['M01.060.057'], ['M01.060.116'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['M01.060.406'], ['M01.060.406.448'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Statistical Exploration of Local Transmission Routes for African Swine Fever in Pigs in the Russian Federation, 2007-2014. | African swine fever (ASF) is a devastating viral disease of swine that is present in both pigs and wild boar in the western part of the Russian Federation and the eastern part of the European Union. It represents a significant threat for the European pig production industry as neither treatment nor vaccine is available... | ['African Swine Fever', 'African Swine Fever Virus', 'Animals', 'Disease Outbreaks', 'Russia', 'Spatio-Temporal Analysis', 'Sus scrofa', 'Swine'] | 26,192,820 | [['C01.920.930.125', 'C01.925.081.078', 'C01.925.256.142', 'C22.905.072'], ['B04.280.049.035'], ['B01.050'], ['N06.850.290'], ['Z01.252.122.500', 'Z01.542.248.775'], ['E05.318.740.933.500', 'N05.715.360.750.746.500', 'N06.850.520.830.933.500'], ['B01.050.150.900.649.313.500.880.399'], ['B01.050.150.900.649.313.500.880'... | ['Diseases [C]', 'Organisms [B]', 'Health Care [N]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Intestinal epithelial damage in sids babies and its similarity to that caused by bacterial toxins in the rabbit. | Sections of the duodenum, jejunum, ileum, caecum and large intestine from 14 sudden infant death syndrome (SIDS) babies were examined by scanning (SEM) and transmission electron microscopy (TEM). The type and amount of damage was characterised and quantitated and compared with the presence of Clostridium perfringens, C... | ['Animals', 'Bacterial Toxins', 'Clostridioides difficile', 'Clostridium perfringens', 'Enterotoxins', 'Escherichia coli', 'Feces', 'Humans', 'Immunoenzyme Techniques', 'Infant', 'Infant, Newborn', 'Intestinal Diseases', 'Intestinal Mucosa', 'Microscopy, Electron, Scanning', 'Rabbits', 'Staphylococcus aureus', 'Sudden ... | 11,358,053 | [['B01.050'], ['D23.946.123'], ['B03.353.625.657.500'], ['B03.300.390.400.200.575', 'B03.353.625.375.500.575', 'B03.510.415.400.200.575'], ['D23.946.330'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['A12.459'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.478.566.350', 'E05.478.583.400', 'E05.60... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A Novel Medical Device for Early Detection of Melanoma. | Melanoma is the deadliest form of skin cancer. Early detection of melanoma is vital, as it helps in decreasing the death rate as well as treatment costs. Dermatologists are using image-based diagnostic tools to assist them in decision-making and detecting melanoma at an early stage. We aim to develop a novel handheld m... | ['Computer-Aided Design', 'Computers', 'Early Detection of Cancer', 'Humans', 'Melanoma', 'Skin Neoplasms'] | 31,156,102 | [['L01.224.108.150', 'L01.296.110.150'], ['L01.224.230.260'], ['E01.390.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.465.625.650.510', 'C04.557.580.625.650.510', 'C04.557.665.510'], ['C04.588.805', 'C17.800.882']] | ['Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
5alpha-Androstane-3alpha,17beta-diol activates pathway that resembles the epidermal growth factor responsive pathways in stimulating human prostate cancer LNCaP cell proliferation. | 5alpha-Androstane-3alpha,17beta-diol (3alpha-diol) is considered to have no androgenic effects in androgen target organs unless it is oxidized to 5alpha-dihydrotestosterone (5alpha-DHT). We used microarray and bioinformatics to identify and compare 3alpha-diol and 5alpha-DHT responsive gene in human prostate LNCaP cell... | ['Anabolic Agents', 'Androstane-3,17-diol', 'Cell Proliferation', 'Computational Biology', 'Epidermal Growth Factor', 'Gene Expression Profiling', 'Humans', 'Male', 'Oligonucleotide Array Sequence Analysis', 'Prostatic Neoplasms', 'Receptors, Androgen', 'Signal Transduction', 'Tumor Cells, Cultured'] | 15,452,555 | [['D27.505.696.399.472.080'], ['D04.210.500.054.040.080', 'D06.472.334.851.968.500'], ['G04.161.750', 'G07.345.249.410.750'], ['H01.158.273.180', 'L01.313.124'], ['D06.472.317.350', 'D12.644.276.382.500', 'D12.776.467.382.500', 'D23.529.382.500'], ['E05.393.332'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Ectopic osteogenic tissue formation by MC3T3-E1 cell-laden chitosan/hydroxyapatite composite scaffold. | This study evaluates the suitability of a macroporous three-dimensional chitosan/hydroxyapatite (CS/HA) composite as a bone tissue engineering scaffold using MC3T3-E1 cells. The CS/HA scaffold was produced by freeze-drying, and characterized by means of SEM and FTIR. In vitro findings demonstrated that CS/HA supported ... | ['Animals', 'Bone Regeneration', 'Cell Line', 'Chitosan', 'Durapatite', 'Mice', 'Osteogenesis', 'Rats', 'Rats, Wistar', 'Tissue Scaffolds'] | 25,968,048 | [['B01.050'], ['G11.427.213.140', 'G16.762.150.150'], ['A11.251.210'], ['D05.750.078.139.500', 'D09.698.211.500'], ['D01.029.260.700.675.374.075.025.300.150', 'D01.146.360.050.300.200', 'D01.578.122.477.300', 'D01.695.625.675.650.075.025.300.150'], ['B01.050.150.900.649.313.992.635.505.500'], ['G07.345.500.325.377.625.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Effect of colchicine and 3H-thymidine on the proliferation and mitotic cycle of chick embryo cells in the gastrulation period]. | The effect of colchicine and 3H-thymidine on the proliferation and mitotic cycle of cells of different rudiments of the chick embryo has been studied during gastrulation. Colchicine (1-10-6 g/ml) was shown not to influence both the portion of cells synthesizing DNA and entering mitosis and the intensity of DNA synthesi... | ['Animals', 'Cell Cycle', 'Cell Division', 'Chick Embryo', 'Colchicine', 'DNA', 'Kinetics', 'Mitosis', 'Thymidine', 'Tritium'] | 904,858 | [['B01.050'], ['G04.144'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A13.350.150', 'A16.331.200'], ['D03.132.225'], ['D13.444.308'], ['G01.374.661', 'G02.111.490'], ['G04.144.220.220.781', 'G05.113.220.781'], ['D03.383.742.680.705', 'D13.570.230.855', 'D13.570.685.705'], ['D01.268.406.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Continuous-flow ozonation over modified ceramsite: implications for the degradation of cation red x-GRL. | Catalytic ozonation has been widely used for refractory dye wastewater treatment due to highly reactive HO·. In this study, a kind of low-cost and environmental-friendly modified ceramsite sphere derived from pyrite cinder, silty clay and kaolin was prepared as ozonation catalyst. The degradation performances of cation... | ['Azo Compounds', 'Catalysis', 'Cations', 'Models, Chemical', 'Ozone', 'Water Pollutants, Chemical'] | 30,767,922 | [['D02.172'], ['G02.130'], ['D01.248.497.300'], ['E05.599.495'], ['D01.362.670.600'], ['D27.888.284.903.655']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A New Approach for Deep Gray Matter Analysis Using Partial-Volume Estimation. | INTRODUCTION: The existence of partial volume effects in brain MR images makes it challenging to understand physio-pathological alterations underlying signal changes due to pathology across groups of healthy subjects and patients. In this study, we implement a new approach to disentangle gray and white matter alteratio... | ['Adult', 'Basal Ganglia', 'Case-Control Studies', 'Female', 'Gray Matter', 'Humans', 'Image Processing, Computer-Assisted', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Multiple Sclerosis', 'Thalamus', 'White Matter', 'Young Adult'] | 26,845,760 | [['M01.060.116'], ['A08.186.211.200.885.287.249'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['A08.186.211.168', 'A08.186.854.348'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['E01.370.350.825.500'], ['M01.060.116.630'], ['C10.114.375.500', 'C10.314.350.500',... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Information Science [L]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Disruption of OsYSL15 leads to iron inefficiency in rice plants. | Uptake and translocation of metal nutrients are essential processes for plant growth. Graminaceous species release phytosiderophores that bind to Fe(3+); these complexes are then transported across the plasma membrane. We have characterized OsYSL15, one of the rice (Oryza sativa) YS1-like (YSL) genes that are strongly ... | ['Actins', 'Cell Membrane', 'Gene Expression Regulation, Plant', 'Genes, Plant', 'Genetic Complementation Test', 'Glucuronidase', 'Homeostasis', 'Iron', 'Membrane Transport Proteins', 'Molecular Sequence Data', 'Mutation', 'Nitric Oxide', 'Oryza', 'Phenotype', 'Plant Proteins', 'Plant Roots', 'Plant Shoots', 'Plants, G... | 19,376,836 | [['D05.750.078.730.250', 'D12.776.210.500.100', 'D12.776.220.525.255'], ['A11.284.149'], ['G05.308.375'], ['G05.360.340.024.340.393', 'G05.360.340.365.500'], ['E05.393.281.526'], ['D08.811.277.450.426'], ['G07.410'], ['D01.268.556.412', 'D01.268.956.287', 'D01.552.544.412'], ['D12.776.157.530', 'D12.776.543.585'], ['L0... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Intrafamilial Transmission of Hepatitis C Virus Among Families of Infected Pediatric Oncology Patients. | BACKGROUND: Hepatitis C virus (HCV) is the most commonly encountered blood transmittable hepatitis among cancer patients. Several studies have reported clustering of HCV infections in families or household contacts of infected cases. Data about the epidemiologic aspects of intrafamilial transmission from pediatric canc... | ['Adolescent', 'Adult', 'Case-Control Studies', 'Child', 'Child, Preschool', 'Cross-Sectional Studies', 'Disease Transmission, Infectious', 'Egypt', 'Family Characteristics', 'Family Health', 'Female', 'Hepatitis C', 'Hepatitis C Antibodies', 'Hospitals, University', 'Humans', 'Infant', 'Infant, Newborn', 'Interviews a... | 30,985,515 | [['M01.060.057'], ['M01.060.116'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['M01.060.406'], ['M01.060.406.448'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['N06.850.335'], ['Z01.058.266.317'], ['F01.829.263.315', 'I01.240.361', 'I01.880.853.150... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Information Science [L]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
Selection of the type of urinary diversion in conjunction with radical cystectomy. | Several different methods of urinary diversion currently are available for use in conjunction with radical cystectomy. The method of urinary diversion performed at the time of radical cystectomy was reviewed for patients undergoing surgery from April 1984 through March 1986. A total of 91 urinary diversions was perform... | ['Humans', 'Ileum', 'Urinary Bladder', 'Urinary Bladder Neoplasms', 'Urinary Diversion'] | 3,586,145 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['A03.556.124.684.249', 'A03.556.249.124'], ['A05.810.890'], ['C04.588.945.947.960', 'C12.758.820.968', 'C12.777.829.813', 'C13.351.937.820.945', 'C13.351.968.829.707'], ['E04.950.774.852']] | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Discrepancies in the values of standard atmospheric pressure: the riddle resolved. | Over half a century ago, when I took Beginning Physics at university, I was bothered by the anomaly that normal air pressure (which is arbitrary anyhow) was taken to be 1.013250 bar instead of a sensible 1.000000 bar. My professor could not explain why, nor could any of the many other scientists whom I have asked since... | ['Air Pressure', 'Atmospheric Pressure', 'History, 17th Century', 'History, 18th Century', 'History, 19th Century', 'History, 20th Century', 'Physics', 'Sensitivity and Specificity'] | 11,468,797 | [['G16.500.750.274.100', 'N06.230.300.100.185.100'], ['G16.500.750.274', 'N06.230.300.100.185'], ['K01.400.504.750'], ['K01.400.504.875'], ['K01.400.504.937'], ['K01.400.504.968'], ['H01.671'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700', 'N05.715.360.750.725', 'N06.850.520.445.800', 'N06.85... | ['Phenomena and Processes [G]', 'Health Care [N]', 'Humanities [K]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Building psychological resilience in support staff caring for people with intellectual disabilities: pilot evaluation of an acceptance-based intervention. | Support staff in intellectual disability services may experience significant work-related stress. The aim of the present study was to pilot an intervention called the Promotion of Acceptance in Carers and Teachers (PACT). Fourteen staff provided data on work stress and general wellbeing before and after attending PACT ... | ['Activities of Daily Living', 'Adaptation, Psychological', 'Adult', 'Attitude of Health Personnel', 'Burnout, Professional', 'Education', 'Female', 'Follow-Up Studies', 'Home Care Services', 'Humans', 'Intellectual Disability', 'Job Satisfaction', 'Male', 'Mental Disorders', 'Middle Aged', 'Pilot Projects', 'Resilienc... | 19,332,508 | [['E02.760.169.063.500.067', 'E02.831.067', 'I03.050', 'N02.421.784.110'], ['F01.058'], ['M01.060.116'], ['F01.100.050', 'N05.300.100'], ['C24.580.500', 'F01.145.126.990.367.500', 'F02.830.900.333.500'], ['I02'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['N02.421.143.52... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Named Groups [M]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
InfleCS: Clustering Free Energy Landscapes with Gaussian Mixtures. | Free energy landscapes provide insights into conformational ensembles of biomolecules. In order to analyze these landscapes and elucidate mechanisms underlying conformational changes, there is a need to extract metastable states with limited noise. This has remained a formidable task, despite a plethora of existing clu... | ['Calmodulin', 'Cluster Analysis', 'Entropy', 'Molecular Dynamics Simulation', 'Molecular Structure', 'Static Electricity'] | 31,647,864 | [['D12.644.360.372.249', 'D12.776.157.125.412.249', 'D12.776.476.387.249'], ['E05.318.740.250', 'N05.715.360.750.200', 'N06.850.520.830.250'], ['G01.906.345'], ['E05.599.595.500', 'G02.111.570.895', 'L01.224.160.500'], ['G02.111.570', 'G02.466'], ['G01.358.500.249.820']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Information Science [L]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Stable mixed acidemia in anesthetized pigs--a model for research on biocompatibility of hemofilters under a deteriorated acid-base balance. | In recent years, acidosis has been of growing interest in intensive care medicine. Most animal models only provide a short-term investigation of the effects of acidosis. They are not suitable for research on interactions with extracorporeal organ support (here continuous venovenous hemofiltration, CVVH). The rationale ... | ['Acidosis', 'Animals', 'Disease Models, Animal', 'Hemofiltration', 'Hydrochloric Acid', 'Lactic Acid', 'Male', 'Materials Testing', 'Swine'] | 21,323,687 | [['C18.452.076.176'], ['B01.050'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['E02.870.225', 'E04.292.471'], ['D01.029.260.326', 'D01.210.450'], ['D02.241.511.459.450'], ['E05.570'], ['B01.050.150.900.649.313.500.880']] | ['Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The acoustic role of tracheal chambers and nasal cavities in the production of sonar pulses by the horseshoe bat, Rhinolophus hildebrandti. | The acoustic role of the enlarged, bony, nasal cavities and rigid tracheal chambers in the horseshoe bat, Rhinolophus hildebrandti (Fig. 2) was investigated by determining the effect of their selective filling on the nasally emitted sonar pulse and on the sound traveling backwards down the trachea. Normal sonar signals... | ['Animals', 'Auditory Perception', 'Brain', 'Chiroptera', 'Nose', 'Sound Localization', 'Trachea', 'Vocalization, Animal'] | 3,397,922 | [['B01.050'], ['F02.463.593.071', 'G07.888.125'], ['A08.186.211'], ['B01.050.150.900.649.313.937'], ['A01.456.505.733', 'A04.531', 'A09.531'], ['F02.463.593.071.869', 'G07.888.125.869'], ['A04.889'], ['F01.145.113.055.800']] | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Assay Conditions Influence Affinities of Rat Organic Cation Transporter 1: Analysis of Mutagenesis in the Modeled Outward-Facing Cleft by Measuring Effects of Substrates and Inhibitors on Initial Uptake. | The effects of mutations in the modeled outward-open cleft of rat organic cation transporter 1 (rOCT1) on affinities of substrates and inhibitors were investigated. Human embryonic kidney 293 cells were stably transfected with rOCT1 or rOCT1 mutants, and uptake of the substrates 1-methyl-4-phenylpyridinium+ (MPP+) and ... | ['1-Methyl-4-phenylpyridinium', 'Animals', 'Catecholamine Plasma Membrane Transport Proteins', 'Dose-Response Relationship, Drug', 'Female', 'HEK293 Cells', 'Humans', 'Mutagenesis', 'Quaternary Ammonium Compounds', 'Rats', 'Substrate Specificity', 'Xenopus laevis'] | 29,339,398 | [['D03.383.725.762.550'], ['B01.050'], ['D12.776.157.530.562.374.500', 'D12.776.543.585.562.374.500'], ['G07.690.773.875', 'G07.690.936.500'], ['A11.251.210.172.750', 'A11.436.334'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G05.558'], ['D01.625.062.500', 'D02.092.877', 'D02.675.276'], ['B01.050.150.900.649.31... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Lipid mediators of autophagy in stress-induced premature senescence of endothelial cells. | Our group (Patschan S, Chen J, Gealekman O, Krupincza K, Wang M, Shu L, Shayman JA, Goligorsky MS; Am J Physiol Renal Physiol 294: F100-F109, 2008) previously observed an accumulation of gangliosides coincident with development of cell senescence and demonstrated lysosomal permeabilization in human umbilical vein endot... | ['Aging', 'Apoptosis', 'Autophagy', 'Cells, Cultured', 'Ceramides', 'Chromatography, High Pressure Liquid', 'Endothelial Cells', 'Fluorescent Antibody Technique', 'Humans', 'Immunohistochemistry', 'Indicators and Reagents', 'Lipids', 'Lysophospholipids', 'Lysosomes', 'Membrane Microdomains', 'Microtubule-Associated Pro... | 18,203,850 | [['G07.345.124'], ['G04.146.954.035'], ['G04.011'], ['A11.251'], ['D02.065.313', 'D09.400.410.420.525.200', 'D10.390.470.675.200', 'D10.570.877.360.612.200'], ['E05.196.181.400.300'], ['A11.436.275'], ['E01.370.225.500.607.512.240', 'E01.370.225.750.551.512.240', 'E05.200.500.607.512.240', 'E05.200.750.551.512.240', 'E... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
A multi-spectroscopic study on the interaction of food polyphenols with a bioactive gluten peptide: From chemistry to biological implications. | This study aims to exploit the molecular and cellular mechanisms concerning the functionality of dietary polyphenols (catechin, procyanidin B3, procyanidin C2, epigallocatechin and epigallocatechin gallate) in a nutritional context to prevent Celiac Disease (CD). In that sense, the interaction between the main CD bioac... | ['Food', 'Glutens', 'Intestinal Mucosa', 'Peptide Fragments', 'Polyphenols', 'Protein Binding', 'Protein Transport', 'Spectrum Analysis'] | 31,284,245 | [['G07.203.300', 'J02.500'], ['D12.776.765.433.500.500', 'D12.776.765.725.500.500'], ['A03.556.124.369', 'A10.615.550.444'], ['D12.644.541'], ['D02.455.426.559.389.657.715', 'D03.633.100.150.266.450.260.777'], ['G02.111.679', 'G03.808'], ['G03.143.700'], ['E05.196.867']] | ['Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
In vitro and in vivo activity of 1-(1-naphthyl)piperazine at terminal 5-HT autoreceptors in guinea-pig brain. | The effect of 1-(1-naphthyl)piperazine (NP) on the 5-HT terminal autoreceptor modulating 5-HT release was investigated in vitro and in vivo. In vitro 5-HT release was measured in slices of guinea-pig substantia nigra and hypothalamus prelabelled with 3H-5-HT, superfused with Krebs solution and depolarized electrically.... | ['Animals', 'Brain Chemistry', 'Electric Stimulation', 'Extracellular Space', 'Guinea Pigs', 'Hydroxylation', 'Hypothalamus', 'In Vitro Techniques', 'Male', 'Microdialysis', 'Nerve Endings', 'Piperazines', 'Receptors, Serotonin', 'Serotonin', 'Serotonin Receptor Agonists', 'Substantia Nigra', 'Tetrodotoxin', 'Tryptopha... | 7,630,428 | [['B01.050'], ['G02.111.150', 'G03.185'], ['E05.723.402'], ['A10.082.500', 'A11.284.295'], ['B01.050.150.900.649.313.992.550'], ['G02.111.385', 'G02.607.348', 'G03.425'], ['A08.186.211.180.497', 'A08.186.211.200.317.357'], ['E05.481'], ['E05.196.353.500'], ['A08.800.550'], ['D03.383.606'], ['D12.776.543.750.670.800', '... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Disseminated cryptococcosis complicated with bilateral pleural effusion and ascites during corticosteroid therapy for organizing pneumonia with myelodysplastic syndrome. | An 83-year-old man with myelodysplastic syndrome was admitted to our hospital due to dyspnea and abnormal shadows on chest X-ray films during corticosteroid therapy for organizing pneumonia. He was diagnosed as having disseminated cryptococcosis with pulmonary lesions after detecting Cryptococcus neoformans. Both bilat... | ['Adrenal Cortex Hormones', 'Aged, 80 and over', 'Ascites', 'Cryptococcosis', 'Cryptogenic Organizing Pneumonia', 'Humans', 'Male', 'Myelodysplastic Syndromes', 'Pleural Effusion'] | 19,015,612 | [['D06.472.040'], ['M01.060.116.100.080'], ['C23.550.081'], ['C01.150.703.248'], ['C08.127.446.135.140.200', 'C08.381.483.487.249', 'C08.381.495.146.135.140.200', 'C08.381.765.500.750.249'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C15.378.190.625'], ['C08.528.652']] | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Platelet PAR1 receptor density--correlation to platelet activation response and changes in exposure after platelet activation. | INTRODUCTION: A polymorphism (-14 A/T) affecting PAR1 expression on the platelet surface has recently been identified. A two-fold variation in receptor density, which correlated with the platelet response to PAR1-activating peptide (PAR1-AP), has been reported.MATERIALS AND METHODS: We used flow cytometry to measure th... | ['Adult', 'Aged', 'Blood Platelets', 'Female', 'Flow Cytometry', 'Humans', 'Male', 'Middle Aged', 'Platelet Activation', 'Platelet Aggregation', 'Receptor, PAR-1'] | 17,675,219 | [['M01.060.116'], ['M01.060.116.100'], ['A11.118.188', 'A15.145.229.188'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.200.500.386.350', 'E05.242.363.342', 'E05.242.386.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['G0... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Leprosy with ANA positive mistaken for connective tissue disease. | Leprosy is associated with the occurrence of various skin lesions such as macules, papules, plaques, nodules, and even diffused infiltration, depending on the patient's immune response. Its clinical presentation is often different from the usual pattern, leading to confusion in diagnosis. We present a case of leprosy w... | ['Antibodies, Antinuclear', 'Biopsy', 'Connective Tissue Diseases', 'Diagnosis, Differential', 'Diagnostic Errors', 'Edema', 'Female', 'Humans', 'Hypesthesia', 'Leprosy', 'Middle Aged', 'Skin Ulcer'] | 23,381,668 | [['D12.776.124.486.485.114.323.204', 'D12.776.124.790.651.114.323.204', 'D12.776.377.715.548.114.323.204'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['C17.300'], ['E01.171'], ['E01.354', 'N02.421.450.280'], ['C23.888.2... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Methodological problems and results of light microscopic morphometric studies on the rat myocardium]. | Morphometrical results obtained on rat myocard by means of 2 different histological techniques (conventional and semithin slices) have been compared. For certain parameters the abovementioned techniques provided different values. For an exact estimation of all parameters of myocardial cells a combination of semithin se... | ['Animals', 'Cell Nucleus', 'Extracellular Space', 'Male', 'Methods', 'Microscopy', 'Myocardium', 'Organoids', 'Rats'] | 7,450,473 | [['B01.050'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['A10.082.500', 'A11.284.295'], ['E05.581'], ['E01.370.350.515', 'E05.595', 'H01.671.617.562'], ['A02.633.580', 'A07.541.704', 'A10.690.552.750'], ['A10.802'], ['B01.050.150.900.649.313.992.635.505.700']] | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Anchor clip technique helps in easy prevention of post-polypectomy hemorrhage of large colonic polyps. | Large colonic polyps have large vessels, which often cause post-polypectomy hemorrhage. Some of the stalks of large pedunculated polyps are formed by the weight of the polyps and disappear after polypectomy. There are some reports suggesting that pre-ligation with Endoloop(R) may minimize the risk of post-polypectomy h... | ['Colonic Polyps', 'Gastrointestinal Hemorrhage', 'Hemostasis, Surgical', 'Humans', 'Postoperative Complications', 'Surgical Instruments'] | 21,175,500 | [['C23.300.825.411.235'], ['C06.405.227', 'C23.550.414.788'], ['E02.520.490', 'E04.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.767'], ['E07.858.700']] | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Calcium phosphate in catheter encrustation. | Encrusted catheters from nine female patients were the source of samples of deposits which were examined by X-ray diffraction, atomic absorption spectroscopy, infra-red spectroscopy and extended X-ray absorption fine structure (EXAFS) spectroscopy. In eight samples the only crystalline phase which could be clearly dist... | ['Catheters, Indwelling', 'Crystallization', 'Durapatite', 'Female', 'Humans', 'Hydroxyapatites', 'Magnesium', 'Magnesium Compounds', 'Phosphates', 'Spectrum Analysis', 'Struvite', 'Urinary Catheterization'] | 3,030,487 | [['E07.132.500'], ['E05.196.300', 'G02.171'], ['D01.029.260.700.675.374.075.025.300.150', 'D01.146.360.050.300.200', 'D01.578.122.477.300', 'D01.695.625.675.650.075.025.300.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.029.260.700.675.374.075.025.300', 'D01.146.360.050.300', 'D01.578.122.477', 'D01.695.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Molecular Pathway of Microtubule Organization at the Golgi Apparatus. | The Golgi apparatus controls the formation of non-centrosomal microtubule arrays important for Golgi organization, polarized transport, cell motility, and cell differentiation. Here, we show that CAMSAP2 stabilizes and attaches microtubule minus ends to the Golgi through a complex of AKAP450 and myomegalin. CLASPs stab... | ['A Kinase Anchor Proteins', 'Cell Line', 'Cell Movement', 'Cell Polarity', 'Centrioles', 'Cytoskeletal Proteins', 'Golgi Apparatus', 'Humans', 'Imaging, Three-Dimensional', 'Intracellular Membranes', 'Microtubule-Associated Proteins', 'Microtubules', 'Protein Binding', 'Protein Stability', 'Pyrimidines', 'Signal Trans... | 27,666,745 | [['D12.644.360.024.065', 'D12.776.157.057.003', 'D12.776.476.024.069'], ['A11.251.210'], ['G04.198', 'G07.568.500.180'], ['G04.250'], ['A11.284.430.214.190.750.585.160.130', 'A11.284.430.214.190.750.820.500.500.130'], ['D12.776.220'], ['A11.284.430.214.190.875.336'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
[Closed traumas of the kidney in children. Conservative treatment]. | Therapeutic approach to 36 children with blunt trauma of the kidney is reported. Generally, conservative attitude was applied. In case of type II or type III lesions, according to the Hodges classification, or when a urohematoma does not regress or worsens, we propose endoscopic drainage to avoid complications. Seventy... | ['Child', 'Drainage', 'Endoscopy', 'Follow-Up Studies', 'Humans', 'Kidney', 'Kidney Diseases', 'Monitoring, Physiologic', 'Nephrectomy', 'Tomography, X-Ray Computed'] | 8,763,600 | [['M01.060.406'], ['E02.309', 'E04.237'], ['E01.370.388.250', 'E04.502.250'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A05.810.453'], ['C12.777.419', 'C13.351.968.419'], ['E01.370.520'], ['E04.950.774.435'], ['E01.370.3... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Analysis of S-adenosylmethionine and related sulfur metabolites in animal tissues. | A high-performance liquid chromatographic method was devised that separates S-adenosylmethionine and related sulfur metabolites on a Radial-PAK SCX cation-exchange column using a four-step NH4COOH/(NH4)2SO4 elution gradient. This new procedure permits, in a single run of 60 min, the quantitative analysis of S-adenosylm... | ['Adrenal Glands', 'Animals', 'Chemical Phenomena', 'Chemistry', 'Chromatography, High Pressure Liquid', 'Fishes', 'HeLa Cells', 'Humans', 'Liver', 'Male', 'Rats', 'Rats, Inbred Strains', 'S-Adenosylmethionine', 'Spleen', 'Sulfur'] | 6,496,925 | [['A06.300.071'], ['B01.050'], ['G02'], ['H01.181'], ['E05.196.181.400.300'], ['B01.050.150.900.493'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A03.620'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760', 'B01.050.150.900.64... | ['Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Summary Care Records in urgent and emergency care in England. | Summary Care Records (SCRs) have been created for more than 50% of the population of England. The number is increasing at about 100,000 records a week. Fewer than 1.5% of people have elected not to have a SCR. SCRs contain updated details of patient medication, allergies and adverse reactions, electronically extracted ... | ['Continuity of Patient Care', 'Electronic Health Records', 'Emergency Medical Services', 'England', 'Humans', 'Patient Safety', 'Quality of Health Care', 'State Medicine'] | 24,098,879 | [['E02.760.169', 'N02.421.585.169', 'N04.590.233.727.210'], ['E05.318.308.940.968.625.500', 'N04.452.859.564.650.125', 'N05.715.360.300.715.500.530.250', 'N06.850.520.308.940.968.625.250'], ['N02.421.297'], ['Z01.542.363.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N06.850.135.060.075.399'], ['N04.761', 'N... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
[Do lactoferrin, lysozyme and the lactoperoxidase-thiocyanate-hydrogen peroxide-system cause negative microbiological results in mastitis secretions?]. | Lactoferrin, lysozyme and the lactoperoxidase-thiocyanate-peroxide-system are naturally occurring antimicrobial components of milk. The objective of this study was to examine, whether these components were responsible for negative results, when mastitis milk is cultured microbiologically. Quarter milk samples from 75 c... | ['Animals', 'Cattle', 'Female', 'Fermentation', 'Hydrogen Peroxide', 'Lactoferrin', 'Lactoperoxidase', 'Mastitis, Bovine', 'Milk', 'Muramidase', 'Thiocyanates'] | 12,161,968 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['G02.111.158.249', 'G03.191.249'], ['D01.248.497.158.685.750.424', 'D01.339.431.374.424', 'D01.650.550.750.400', 'D02.389.338.253'], ['D08.811.277.656.300.760.471', 'D08.811.277.656.959.350.471', 'D12.776.157.427.750.249', 'D12.776.256.159.750.816.500.507', 'D12.7... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
HER2 exon 27 mutations predict worse survival of breast cancer patients, especially in HER2-negative patients. | The aims of this study were to assess the prognostic value of the HER2 exon 27 mutations in breast cancer patients. Genomic DNA was isolated from peripheral blood leukocytes, and then HER2 exon 27 mutations were detected by direct sequencing. Survival curves were estimated by Kaplan-Meier curves and the differences bet... | ['Adult', 'Aged', 'Aged, 80 and over', 'Biomarkers, Tumor', 'Breast Neoplasms', 'Chi-Square Distribution', 'DNA Mutational Analysis', 'Disease Progression', 'Disease-Free Survival', 'Exons', 'Female', 'Genetic Predisposition to Disease', 'Humans', 'Kaplan-Meier Estimate', 'Lymphatic Metastasis', 'Middle Aged', 'Multiva... | 29,072,371 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D23.101.140'], ['C04.588.180', 'C17.800.090.500'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['E05.393.760.700.300'], ['C23.550.291.656'], ['E01.789.800.190', 'E05.318.740.998.300', 'N04.761.559.590.800... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Insemination of husband's semen with and without the addition of caffeine. | Four hundred cervicovaginal artificial inseminations using husband's semen were carried out for a variety of clinical indications. Before insemination, to one-half of the samples caffeine was added to a final concentration of 6 mM. Although the motility of the spermatozoa was enhanced in each case, no pregnancies were ... | ['Caffeine', 'Female', 'Humans', 'Insemination, Artificial', 'Insemination, Artificial, Homologous', 'Male', 'Pregnancy', 'Semen', 'Sperm Motility'] | 668,935 | [['D03.132.960.175', 'D03.633.100.759.758.824.175'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.875.800.937', 'E05.820.800.937', 'G08.686.784.363.492'], ['E02.875.800.937.525', 'E05.820.800.937.525', 'G08.686.784.363.492.750'], ['G08.686.784.769'], ['A12.200.732'], ['E01.370.225.992.812', 'E05.200.992.812',... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Oral sustained release tablets of zidovudine using binary blends of natural and synthetic polymers. | Oral sustained release matrix tablets of zidovudine (ZDV) were prepared using different types, proportions and blends of carbopol 71G (C71) and a plant gum obtained from Abelmoschus esculentus (AEG). The effect of various formulation factors like polymer proportion, polymer type and pH of the dissolution medium on the ... | ['Abelmoschus', 'Acrylates', 'Administration, Oral', 'Chemistry, Pharmaceutical', 'Delayed-Action Preparations', 'Plant Extracts', 'Plant Gums', 'Polymers', 'Tablets', 'Zidovudine'] | 20,823,575 | [['B01.650.940.800.575.912.250.859.821.500.100'], ['D02.241.081.069'], ['E02.319.267.100'], ['H01.158.703.007', 'H01.181.466'], ['D26.255.210', 'E02.319.300.253'], ['D20.215.784.500', 'D26.667'], ['D05.750.078.739', 'D09.698.700', 'D20.215.721.249'], ['D05.750', 'D25.720', 'J01.637.051.720'], ['D26.255.830'], ['D03.383... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Oxygen transportation in the blood. | The most important determinants of the overall O2 delivery to tissues are the cardiac output and the arteriovenous O2 content difference. The latter is influenced mainly by the haemoglobin concentration, arterial haemoglobin O2 saturation and venous haemoglobin O2 saturation. Also the O2 tension has a minor contributio... | ['2,3-Diphosphoglycerate', 'Biological Transport', 'Diphosphoglyceric Acids', 'Hemoglobins', 'Humans', 'Oxygen', 'Partial Pressure'] | 7,342,842 | [['D02.241.081.844.387.388.175', 'D02.241.511.902.387.388.175', 'D02.705.400.140.175', 'D09.811.366.388.175'], ['G03.143'], ['D02.241.081.844.387.388', 'D02.241.511.902.387.388', 'D02.705.400.140', 'D09.811.366.388'], ['D12.776.124.400', 'D12.776.422.316.762'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.268... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Outcomes of an automated procedure for the selection of effective platelets for patients refractory to random donors based on cross-matching locally available platelet products. | In 1999, we implemented an automated platelet cross-matching (XM) programme to select compatible platelets from the local inventory for patients refractory to random donor platelets. In this study, we evaluated platelet count increments in 40 consecutive refractory patients (8.3% of 480 consecutive platelet recipients)... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Blood Grouping and Crossmatching', 'Female', 'HLA Antigens', 'Humans', 'Isoantibodies', 'Leukocyte Count', 'Male', 'Middle Aged', 'Platelet Count', 'Platelet Transfusion', 'Program Evaluation', 'Treatment Outcome'] | 15,015,974 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E01.370.225.625.120', 'E01.370.225.812.385.120', 'E05.200.625.120', 'E05.200.812.385.120', 'E05.478.594.385.120'], ['D23.050.301.500.450', 'D23.050.705.552.450'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.124.486.485.114... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Relation between motoneuron position and lateral rectus motor unit contraction speed: an intracellular study in the cat abducens nucleus. | Thirty-one single muscle units of the cat lateral rectus muscle were activated through intracellular stimulation of their motoneurons in the principal abducens nucleus. Motoneurons encountered from dorsal to ventral in the nucleus tended to innervate muscle units with progressively slower contraction times. In addition... | ['Abducens Nerve', 'Animals', 'Axonal Transport', 'Axons', 'Cats', 'Electric Stimulation', 'Horseradish Peroxidase', 'Motor Neurons', 'Muscle Contraction', 'Muscles'] | 6,164,966 | [['A08.800.800.120.030'], ['B01.050'], ['G03.143.355.040', 'G04.392.040', 'G11.561.050'], ['A08.675.542.145', 'A11.284.180.075', 'A11.671.137', 'A11.671.501.145'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['E05.723.402'], ['D08.811.682.732.512'], ['A08.675.655.500', 'A11.671.655.500'], ['G11.427.494'], ['A02.63... | ['Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Health-related service utilization and HIV risk behaviors among HIV infected injection drug users and crack smokers. | This study was designed to assess utilization of health-related services and HIV risk related behaviors by HIV infected drug users one year prior to and two years following the availability of Ryan White Title I funding. Using a cross-sectional design, a total of 777 drug injectors and crack smokers from five US cities... | ['Adult', 'Crack Cocaine', 'Cross-Sectional Studies', 'Female', 'HIV Seropositivity', 'Health Services', 'Humans', 'Male', 'Middle Aged', 'Risk-Taking', 'Smoking', 'Substance Abuse, Intravenous'] | 10,402,151 | [['M01.060.116'], ['D02.145.074.722.388.250', 'D03.132.889.354.250', 'D03.605.084.500.722.388.250', 'D03.605.869.388.250', 'D26.878.250'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['C01.221.250.875.500', 'C01.221.812.640.400.500', 'C01.778.640.400.500', 'C01.925.782.815.616.400.500... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Detection of denervated but viable myocardium in cardiac sarcoidosis with I-123 MIBG and Tl-201 SPECT imaging. | A 58-year-old man, who had biopsy-proven cardiac sarcoidosis, underwent TI-201 and I-123 MIBG cardiac scintigraphy. Although no perfusion defect was identified by Tl-201, mild heterogeneity of I-123 MIBG uptake was present in the myocardium. The denervated but viable myocardium was demonstrated in the heart with sarcoi... | ['3-Iodobenzylguanidine', 'Cardiomyopathies', 'Denervation', 'Heart Conduction System', 'Humans', 'Iodine Radioisotopes', 'Male', 'Middle Aged', 'Radiopharmaceuticals', 'Sarcoidosis', 'Sympathetic Nervous System', 'Thallium Radioisotopes', 'Tomography, Emission-Computed, Single-Photon'] | 11,577,764 | [['D02.078.370.510', 'D02.455.426.559.389.454.300', 'D02.455.526.581.496.300'], ['C14.280.238'], ['E04.525.210'], ['A07.541.409'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.268.380.400.500.496', 'D01.496.448.496', 'D01.496.749.474'], ['M01.060.116.630'], ['D27.505.259.843', 'D27.505.519.871', 'D27.720.470.... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Named Groups [M]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Agranulocytosis in the course of infectious mononucleosis. Demonstration of leukoagglutinins (author's transl)]. | A case of agranulocytosis, quickly and spontaneously reversible, occurring in the fourth week of infectious mononucleosis in a 7-year old girl, is reported. The interest of the case lies in the importance of the symptomatology (jaundice, eruption, fever for 40 days), the serological detection of the role of the Epstein... | ['Agglutinins', 'Agranulocytosis', 'Child', 'Female', 'Humans', 'Infectious Mononucleosis', 'Leukocytes'] | 7,469,685 | [['D27.505.696.477.136', 'D27.505.954.502.270.232'], ['C15.378.553.546.184'], ['M01.060.406'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C01.925.256.466.313.400', 'C15.378.553.381', 'C15.604.515.516', 'C20.683.515.515'], ['A11.118.637', 'A15.145.229.637', 'A15.382.490']] | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Named Groups [M]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Protection against simian immunodeficiency virus vaginal challenge by using Sabin poliovirus vectors. | Here we provide the first report of protection against a vaginal challenge with a highly virulent simian immunodeficiency virus (SIV) by using a vaccine vector. New poliovirus vectors based on Sabin 1 and 2 vaccine strain viruses were constructed, and these vectors were used to generate a series of new viruses containi... | ['Animals', 'Arenaviruses, New World', 'Female', 'Genetic Vectors', 'Humans', 'Macaca', 'Recombination, Genetic', 'Simian Acquired Immunodeficiency Syndrome', 'Simian Immunodeficiency Virus', 'Vagina', 'Viral Vaccines'] | 11,462,016 | [['B01.050'], ['B04.820.480.500.070.095'], ['G05.360.337'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649.313.988.400.112.199.120.510'], ['G05.728'], ['C01.925.782.815.616.850', 'C01.925.839.850', 'C22.735.500.850'], ['B04.820.650.589.650.800', 'B04.820.650.805.700'], ['A05.360.319.779'], ['D20... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Determination of Trace Nickel in Water Samples by Graphite Furnace Atomic Absorption Spectrometry after Mixed Micelle-Mediated Cloud Point Extraction. | A simple and sensitive cloud point extraction method for the preconcentration of ultra-trace amounts of nickel as a prior step to its determination by graphite furnace atomic absorption spectrometry was proposed. It is based on the reaction of nickel with 2-(5-bromo-2-pyridylazo)-5-dimethylaminoaniline (5-Br-PADMA) in ... | ['Aniline Compounds', 'Calibration', 'Graphite', 'Hydrogen-Ion Concentration', 'Ions', 'Limit of Detection', 'Micelles', 'Nickel', 'Octoxynol', 'Polyethylene Glycols', 'Sodium Dodecyl Sulfate', 'Spectrophotometry, Atomic', 'Temperature', 'Time Factors', 'Water Pollutants, Chemical'] | 30,309,038 | [['D02.092.146'], ['E05.978.155'], ['D01.268.150.300', 'D01.578.300'], ['G02.300'], ['D01.248.497'], ['E05.318.740.872.374', 'N05.715.360.750.725.500', 'N06.850.520.830.872.500'], ['D05.374', 'D26.255.560'], ['D01.268.556.607', 'D01.268.956.625', 'D01.552.544.607'], ['D02.033.455.250.700.660', 'D05.750.741.610', 'D25.7... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Proteomic analysis of MCF-7 breast cancer cell line exposed to mitogenic concentration of 17beta-estradiol. | Estrogens are powerful mitogens that play a critical role in the onset of breast cancer and its progression. About two-thirds of all breast cancers are estrogen receptor (ER)+ at the time of diagnosis, and the ER expression is the determinant of a tumor phenotype associated with hormone responsiveness. The molecular ba... | ['Breast Neoplasms', 'Cell Cycle', 'Cell Line, Tumor', 'Chromatography, High Pressure Liquid', 'Electrophoresis, Gel, Two-Dimensional', 'Estradiol', 'Gene Expression Regulation, Neoplastic', 'Humans', 'Mitogens', 'Nanotechnology', 'Proteomics', 'Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization'] | 17,051,647 | [['C04.588.180', 'C17.800.090.500'], ['G04.144'], ['A11.251.210.190', 'A11.251.860.180'], ['E05.196.181.400.300'], ['E05.196.401.250', 'E05.301.300.230'], ['D04.210.500.365.415.248', 'D06.472.334.851.437.500'], ['G05.308.370'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.519.593.624'], ['H01.603', 'J01.8... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
[Elderly women, invisible lesbians]. | The social invisibility of aging lesbians is a major obstacle to the adaptation of residential services to their needs. After looking at the difficulties associated with aging among lesbians, this article examines social mechanisms that reproduce their invisibility. Findings are based on a qualitative analysis of two s... | ['Age Factors', 'Aged', 'Attitude', 'Female', 'Health Facility Environment', 'Health Services Needs and Demand', 'Homes for the Aged', 'Homosexuality, Female', 'Humans', 'Interviews as Topic', 'Mental Health Services', 'Professional Competence', 'Quebec', 'Social Support'] | 15,868,840 | [['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['F01.100'], ['N02.278.220', 'N05.300.430.400'], ['N03.349.380.420', 'N05.300.450'], ['J03.775.462', 'N02.278.825.462'], ['F01.145.802.975.500.400', 'G08.686.867.500.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.420', 'L01.399.250.520... | ['Health Care [N]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Anthropology, Education, Sociology, and Social Phenome... | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 |
[Caloric intake and distribution of the main nutrients in a population of obese children]. | Calorie intake and the main nutrient contents were assessed in a population of 152 obese (OB) children (86 M; 66 F; age 7-11) and 153 normal weight (NW) peers (87 M; 66 F). The following method was used: a) an interview using a food dictionary to assess food intake during the 2 days prior to the study and on one holida... | ['Child', 'Diet Surveys', 'Dietary Carbohydrates', 'Dietary Fats', 'Dietary Proteins', 'Energy Intake', 'Feeding Behavior', 'Female', 'Humans', 'Italy', 'Male', 'Nutrition Assessment', 'Obesity'] | 2,099,995 | [['M01.060.406'], ['E05.318.308.980.485.350', 'N05.715.360.300.800.469.300', 'N06.850.505.616.300', 'N06.850.520.308.980.469.350'], ['D09.301', 'G07.203.300.362', 'J02.500.362'], ['D10.212.302', 'G07.203.300.375', 'J02.500.375'], ['D12.776.256', 'G07.203.300.428', 'J02.500.428'], ['G07.203.650.240.340'], ['F01.145.113.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Geographicals [Z]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
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