Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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DNA alkylations and mutation after exposure to ethyl methanesulphonate in mammalian cell lines routinely used in mutagenicity testing. | DNA ethylations were measured in four mammalian cell lines, Chinese hamster ovary CHO, mouse lymphoma L5178Y t k+/-, human lymphoblastoid TK6 and Chinese hamster V79, following exposure to [3H]ethyl methanesulphonate. Concurrent estimates of cytotoxicity and gene mutation were also carried out. Total DNA-binding and re... | ['Adenine', 'Alkylation', 'Animals', 'Cell Line', 'Chromatography, High Pressure Liquid', 'DNA', 'DNA Damage', 'Ethyl Methanesulfonate', 'Guanine', 'Humans', 'Mutagenicity Tests', 'Mutagens', 'Mutation', 'Tritium'] | 2,184,323 | [['D03.633.100.759.138'], ['G02.111.035', 'G02.607.094', 'G03.059'], ['B01.050'], ['A11.251.210'], ['E05.196.181.400.300'], ['D13.444.308'], ['G05.200'], ['D02.455.326.146.100.050.500.300', 'D02.886.645.600.055.050.510.300'], ['D03.633.100.759.758.399.454'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.393.56... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Inter-domain Cooperation in INCENP Promotes Aurora B Relocation from Centromeres to Microtubules. | The chromosomal passenger complex is essential for error-free chromosome segregation and proper execution of cytokinesis. To coordinate nuclear division with cytoplasmic division, its enzymatic subunit, Aurora B, relocalizes from centromeres in metaphase to the spindle midzone in anaphase. In budding yeast, this requir... | ['Anaphase', 'Aurora Kinase B', 'Centromere', 'Chromosomal Proteins, Non-Histone', 'Chromosome Segregation', 'HeLa Cells', 'Humans', 'Microtubules', 'Protein Binding', 'Protein Structure, Tertiary'] | 26,166,576 | [['G04.144.220.220.687.222', 'G04.144.220.220.781.050', 'G05.113.220.687.250', 'G05.113.220.781.050'], ['D08.811.913.696.620.682.700.103.750', 'D12.776.167.049.750'], ['A11.284.430.106.279.345.190.160.165', 'G05.360.160.165'], ['D12.776.660.235', 'D12.776.664.235'], ['G04.144.220.220.625', 'G05.113.220.625'], ['A11.251... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Performance measures and their benchmarks for assessing organizational cultural competency in behavioral health care service delivery. | A project is described in which performance measures of cultural competency in behavioral health care were selected and benchmarked. Input from an Expert Panel representing the four major ethnic and racial groups in the U.S. and persons with extensive experience in implementing cultural competency in health care, along... | ['Attitude of Health Personnel', 'Benchmarking', 'Consumer Behavior', 'Cultural Diversity', 'Ethnic Groups', 'Health Care Surveys', 'Humans', 'Mental Health Services', 'Needs Assessment', 'Organizational Culture', 'Professional-Patient Relations', 'Quality Indicators, Health Care', 'United States'] | 14,756,197 | [['F01.100.050', 'N05.300.100'], ['N04.452.500.150', 'N04.761.685.150', 'N04.761.700.150', 'N05.700.150', 'N05.715.360.650.150'], ['F01.145.236'], ['I01.076.201.450.350', 'I01.880.853.100.450'], ['M01.686.754', 'N01.224.317'], ['E05.318.308.980.344', 'N03.349.380.210', 'N05.425.210', 'N05.715.360.300.800.344', 'N06.850... | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Predicting developmental outcomes at school entry using a multiple-risk model: four American communities. The Conduct Problems Prevention Research Group. | The contributions of different risk factors in predicting children's psychological and academic outcomes at the end of 1st grade were examined. Using a regression model, levels of ecobehavioral risk were assessed in the following order: specific demographics, broad demographics, family psychosocial status, mother's dep... | ['Achievement', 'Child', 'Child Behavior', 'Child Development', 'Child, Preschool', 'Female', 'Humans', 'Male', 'Maternal Behavior', 'Prognosis', 'Psychology, Child', 'Risk Assessment', 'Socialization', 'United States'] | 10,082,011 | [['F01.658.059', 'F02.784.629.054'], ['M01.060.406'], ['F01.145.179'], ['F01.525.200', 'G07.345.374.750'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.263.370.215'], ['E01.789'], ['F04.096.628.193'], ['E05.318.740.600.800.715', 'N04.452.871.715', 'N05.715.360.750.625.700.690', 'N06.8... | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Low-income Canadians' experiences with health-related services: implications for health care reform. | This study investigated the use of health-related services by low-income Canadians living in two large cities, Edmonton and Toronto. Interview data collected from low-income people, service providers and managers, advocacy group representatives, and senior-level public servants were analyzed using thematic content anal... | ['Alberta', 'Canada', 'Female', 'Health Care Reform', 'Health Services', 'Humans', 'Interviews as Topic', 'Male', 'National Health Programs', 'Ontario', 'Patient Satisfaction', 'Poverty'] | 15,978,694 | [['Z01.107.567.176.064'], ['Z01.107.567.176'], ['I01.655.500.608.400.285', 'I01.880.604.825.608.400.285', 'N03.349.285', 'N03.623.500.608.428.285', 'N04.590.374.285', 'N05.300.380'], ['N02.421'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.420', 'L01.399.250.520', 'N05.715.360.300.400', 'N06.850.520.... | ['Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 1 |
Glutamine reduces myocardial cell apoptosis in a rat model of sepsis by promoting expression of heat shock protein 90. | BACKGROUND: Myocardial cell injury and cardiac myocyte apoptosis are associated with sepsis. Glutamine (Gln) has been reported to repair myocardial cell injury. The aim of this study was to explore the role of Gln on cardiac myocytes in a cecal ligation and puncture (CLP) model of sepsis in Wistar rats.MATERIALS AND ME... | ['Animals', 'Apoptosis', 'Caspases', 'Disease Models, Animal', 'Glutamine', 'HSP90 Heat-Shock Proteins', 'Myocytes, Cardiac', 'Rats, Wistar', 'Sepsis'] | 29,180,187 | [['B01.050'], ['G04.146.954.035'], ['D08.811.277.656.262.500.126', 'D08.811.277.656.300.200.126', 'D12.644.360.075.405', 'D12.776.476.075.405'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['D12.125.068.330', 'D12.125.095.461', 'D12.125.154.424'], ['D12.776.580.216.380'], ['A07.541.704.570', 'A10.690.552.750.570', '... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Human BAHD1 promotes heterochromatic gene silencing. | Gene silencing via heterochromatin formation plays a major role in cell differentiation and maintenance of homeostasis. Here we report the identification and characterization of a novel heterochromatinization factor in vertebrates, bromo adjacent homology domain-containing protein 1 (BAHD1). This nuclear protein intera... | ['Chromatin', 'Chromosomal Proteins, Non-Histone', 'Chromosome Mapping', 'CpG Islands', 'Gene Silencing', 'Heterochromatin', 'Histones', 'Humans', 'Insulin-Like Growth Factor II', 'Lysine', 'Microscopy, Fluorescence', 'Models, Genetic', 'Nuclear Proteins', 'Protein Binding', 'Protein Structure, Tertiary', 'Transcriptio... | 19,666,599 | [['A11.284.430.106.279.345.190.160.180', 'D12.776.664.224', 'G05.360.160.180'], ['D12.776.660.235', 'D12.776.664.235'], ['E05.393.183'], ['G02.111.570.080.380.160', 'G05.360.080.380.160', 'G05.360.340.024.159'], ['G05.308.203.374'], ['A11.284.430.106.279.345.190.160.180.383', 'D12.776.664.224.466', 'G05.360.160.180.383... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Identifying <i>Neogobius</i> species from the southern Caspian Sea by otolith shape (Teleostei: Gobiidae). | Three Neogobius species are common in the southern Caspian Sea. Identification of these species, especially from remains, is not fully understood. The present study compares the morphological characteristics of sagittal otoliths of N. caspius, N. pallasi and N. melanostomus. Furthermore, it also provides a dichotomous ... | ['Animals', 'Female', 'Geography', 'Iran', 'Male', 'Oceans and Seas', 'Perciformes'] | 27,988,598 | [['B01.050'], ['H01.277.500'], ['Z01.252.245.500.350'], ['G01.311.625', 'G16.500.275.725.500.650', 'Z01.756'], ['B01.050.150.900.493.602']] | ['Organisms [B]', 'Disciplines and Occupations [H]', 'Geographicals [Z]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 |
Ossifying hemangioma of the temporal bone. | Intratemporal vascular tumors are more frequent than has previously been noted. Despite their small size, hemangiomas of the temporal bone are extremely aggressive and produce severe neural deficits. The term ossifying hemangioma is used to denote an intratemporal vascular tumor characterized by new bone formation, whi... | ['Adult', 'Diagnosis, Differential', 'Hemangioma', 'Humans', 'Male', 'Ossification, Heterotopic', 'Skull Neoplasms', 'Temporal Bone'] | 2,116,153 | [['M01.060.116'], ['E01.171'], ['C04.557.645.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.751'], ['C04.588.149.721', 'C05.116.231.754'], ['A02.835.232.781.885']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The packaging unit: a basic structural feature for the condensation of late cricket spermatid nuclei. | The alignment, folding and packaging of cricket chromatin was examined during late spermiogenesis by an electron-microscope study of nuclei dispersed by air--liquid surface tension forces after detergent treatment. Late developing spermatid genomes arrange themselves in multiple packaging units in a stepwise process wh... | ['Animals', 'Cell Nucleus', 'Chromatin', 'Male', 'Microscopy, Electron', 'Orthoptera', 'Phosphotungstic Acid', 'Spermatids', 'Spermatogenesis', 'Spermatozoa'] | 721,904 | [['B01.050'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['A11.284.430.106.279.345.190.160.180', 'D12.776.664.224', 'G05.360.160.180'], ['E01.370.350.515.402', 'E05.595.402'], ['B01.050.500.131.617.678'], ['D01.029.260.700.675.750', 'D01.695.625.675.750', 'D01.940.700'], ['A05.360.490.890.860', 'A11.497.760.60... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Verification of model development technique for NIR-based real-time monitoring of ingredient concentration during blending. | There has been a considerable research on the process analytical technology (PAT) and real-time monitoring based on NIR, but the model development is still an important issue and persons in charge have difficulty in building good models. In this study, to realize efficient NIR-based real-time monitoring of ingredient c... | ['Algorithms', 'Drug Compounding', 'Equipment Design', 'Least-Squares Analysis', 'Models, Theoretical', 'Pharmaceutical Preparations', 'Pharmacopoeias as Topic', 'Sensitivity and Specificity', 'Spectroscopy, Near-Infrared'] | 24,834,879 | [['G17.035', 'L01.224.050'], ['E05.916.270'], ['E05.320'], ['E05.318.740.750.400', 'N05.715.360.750.695.440', 'N06.850.520.830.750.400'], ['E05.599'], ['D26'], ['L01.178.682.192.836.749'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700', 'N05.715.360.750.725', 'N06.850.520.445.800', 'N06.850.520... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Masc2, a C5-DNA-methyltransferase from Ascobolus immersus with similarity to methyltransferases of higher organisms. | The filamentous fungus Ascobolus immersus represents an eukaryotic model organism to study genetic phenomena linked to DNA methylation. Following our previous characterization of a gene, masc1 from A. immersus, encoding the 'de novo' C5-DNA-methyltransferase (MTase), we report here the identification of a second MTase ... | ['Amino Acid Sequence', 'Animals', 'Ascomycota', 'Base Sequence', 'Cell Line', 'Cloning, Molecular', 'DNA (Cytosine-5-)-Methyltransferases', 'DNA Methylation', 'DNA, Fungal', 'Fungal Proteins', 'Gene Expression', 'Humans', 'Molecular Sequence Data', 'Sequence Homology, Amino Acid', 'Spodoptera'] | 9,461,345 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['B01.300.107'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A11.251.210'], ['E05.393.220'], ['D08.811.913.555.500.350.100.500'], ['G02.111.035.538.161', 'G02.111.218', 'G03.059.538.161', 'G05.206'], ['D13.444.308.300'], ['D12.776.354'], ['G05.2... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Thirty-five years of paediatric scalds: are lessons being learned? | All paediatric scalds admitted in 1991 to the Welsh Centre for Burns and Plastic Surgery have been analysed retrospectively and the results compared with similar studies from this centre reported in 1956 and 1984. This data was compared with similar reports from 6 other world-wide centres. Despite a modest population i... | ['Accident Prevention', 'Accidents, Home', 'Age Distribution', 'Burns', 'Child, Preschool', 'Female', 'Humans', 'Incidence', 'Infant', 'Infant, Newborn', 'Male', 'Retrospective Studies', 'Wales'] | 7,743,043 | [['N06.850.135.060'], ['N06.850.135.217'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['C26.200'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.985.525.375'], ['M01.060.703'], ['M01.06... | ['Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Diseases [C]', 'Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Role of adiponectin in preventing vascular stenosis. The missing link of adipo-vascular axis. | Obesity is more linked to vascular disease, including atherosclerosis and restenotic change, after balloon angioplasty. The precise mechanism linking obesity and vascular disease is still unclear. Previously we have demonstrated that the plasma levels of adiponectin, an adipose-derived hormone, decreases in obese subje... | ['Adenoviridae', 'Adiponectin', 'Animals', 'Cell Division', 'Cells, Cultured', 'Collagen', 'Coronary Disease', 'DNA Replication', 'Endothelium, Vascular', 'Intercellular Signaling Peptides and Proteins', 'Mice', 'Mice, Knockout', 'Obesity', 'Proteins', 'RNA, Messenger', 'Transcription, Genetic', 'Tunica Intima', 'Vascu... | 12,138,120 | [['B04.280.030'], ['D06.472.699.042.249', 'D12.644.276.024.249', 'D12.644.548.011.249', 'D12.776.467.024.249', 'D23.529.024.249'], ['B01.050'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.251'], ['D05.750.078.280', 'D12.776.860.300.250'], ['C14.280.647.250', 'C14.907.585.250'], ['G02... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Little cherry virus-2: sequence and genomic organization of an unusual member of the Closteroviridae. | The complete genomic sequence of variant USA6b of Little cherry virus-2 (LChV-2), has been determined and is 15045 nucleotides in length, coding for 11 open reading frames (ORFs). The sequence shares 77.2% identity with a previously published, ca. 6 kb partial replicase sequence of LChV-2 (variant USA6a). Both LChV-2/U... | ['Amino Acid Sequence', 'Closteroviridae', 'Genome, Viral', 'Molecular Sequence Data', 'Open Reading Frames', 'Prunus', 'RNA, Viral'] | 15,449,137 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B04.715.110', 'B04.820.578.313'], ['G05.360.340.358.840'], ['L01.453.245.667'], ['G05.360.335.760.640', 'G05.360.340.024.340.137.650'], ['B01.650.940.800.575.912.250.859.937.500.625'], ['D13.444.735.828']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Suitability of saphenous vein graft lesions for the use of distal embolic protection devices. | The use of distal embolic protection devices (EPD) in saphenous vein graft percutaneous interventions (SVG-PCI) has been associated with a decrease in adverse events. Currently, there are limited data regarding the percentage of SVG lesions that are suitable for EPD deployment. We retrospectively reviewed 131 SVG-PCI p... | ['Aged', 'Aged, 80 and over', 'Angioplasty, Balloon, Coronary', 'Coronary Disease', 'Cross-Sectional Studies', 'Embolism', 'Female', 'Graft Occlusion, Vascular', 'Humans', 'Male', 'Middle Aged', 'Registries', 'Retrospective Studies', 'Saphenous Vein', 'Treatment Outcome'] | 18,987,394 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['E02.148.050.060.100', 'E04.100.376.719.100', 'E04.100.814.529.124.060.100', 'E04.100.814.529.968.050', 'E04.502.382.124.060.100', 'E04.502.382.968.050', 'E04.928.220.520.100', 'E05.157.016.060.100'], ['C14.280.647.250', 'C14.907.585.250'], ['E05.318.372.500.875', 'N05.71... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[The application of partial 3D reconstruction for the maxillofacial tumor resection with one-stage reconstruction]. | OBJECTIVE: To introduce a novel digital surgery technique based on partial reconstruction of skull and its application in tumor resection and on-sport reconstruction surgery.METHODS: The partial 3d reconstruction according to CT scanning data was obtained to get 3d model of both tumor and normal skull, then to define t... | ['Adult', 'Female', 'Head and Neck Neoplasms', 'Humans', 'Imaging, Three-Dimensional', 'Male', 'Middle Aged', 'Reconstructive Surgical Procedures', 'Surgery, Computer-Assisted', 'Young Adult'] | 17,554,873 | [['M01.060.116'], ['C04.588.443'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.400', 'L01.224.308.410'], ['M01.060.116.630'], ['E04.680'], ['E04.749'], ['M01.060.116.815']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Updating the nurse's bedside manner. | The current tendency for nurses to be on a first name basis with their patients and to wear less professional clothing provides new metaphors for interpreting nurses' work status. We argue that this prevailing social informality in communications and dress perpetuates themes that diminish the professional image of nurs... | ['Clothing', 'Communication', 'Humans', 'Interprofessional Relations', 'Language', 'Nurse-Patient Relations', 'Nursing Process', 'Organizational Culture', 'Physicians', 'Stereotyping', 'Workplace'] | 8,340,122 | [['J01.637.215'], ['F01.145.209', 'L01.143'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.401.205'], ['F01.145.209.399', 'L01.559'], ['F01.829.401.650.600', 'N05.300.660.560'], ['N04.590.233.508'], ['N04.452.606'], ['M01.526.485.810', 'N02.360.810'], ['F01.100.920', 'F01.145.813.854'], ['N01.824.245.925'... | ['Technology, Industry, and Agriculture [J]', 'Psychiatry and Psychology [F]', 'Information Science [L]', 'Organisms [B]', 'Health Care [N]', 'Named Groups [M]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 0 |
n-3 PUFAs improve erythrocyte fatty acid profile in patients with small AAA: a randomized controlled trial. | Abdominal aortic aneurysm (AAA) is an important cause of death in older adults, which has no current drug therapy. Inflammation and abnormal redox status are believed to be key pathogenic mechanisms for AAA. In light of evidence correlating inflammation with aberrant fatty acid profiles, this study compared erythrocyte... | ['Aged', 'Antioxidants', 'Aortic Aneurysm, Abdominal', 'Erythrocytes', 'Fatty Acid Elongases', 'Fatty Acids', 'Fatty Acids, Omega-3', 'Fatty Acids, Unsaturated', 'Female', 'Gas Chromatography-Mass Spectrometry', 'Humans', 'Linoleic Acid', 'Lipid Metabolism', 'Male', 'Middle Aged'] | 30,914,500 | [['M01.060.116.100'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['C14.907.055.239.075', 'C14.907.109.139.075'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['D08.811.913.050.134.343'], ['D10.251'], ['D10.212.302.380.410', 'D10.251.355.337', 'D10.627.430.450'], ['D10.251.355'], ['E05.196.181.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A partitioning deletion/substitution/addition algorithm for creating survival risk groups. | Accurately assessing a patient's risk of a given event is essential in making informed treatment decisions. One approach is to stratify patients into two or more distinct risk groups with respect to a specific outcome using both clinical and demographic variables. Outcomes may be categorical or continuous in nature; im... | ['Algorithms', 'Brain Diseases', 'Computer Simulation', 'Epidemiologic Methods', 'Humans', 'Incidence', 'Models, Statistical', 'Proportional Hazards Models', 'Regression Analysis', 'Risk Factors', 'Survival Analysis', 'Survival Rate'] | 22,519,965 | [['G17.035', 'L01.224.050'], ['C10.228.140'], ['L01.224.160'], ['E05.318', 'N06.850.520'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.985.525.375'], ['E05.318.740.500', 'E05.599.835', 'N05.715.360.750.530', 'N06.850... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Activation and redistribution of c-jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease. | Cellular responses to increased oxidative stress appear to be a mechanism that contributes to the varied cytopathology of Alzheimer's disease (AD). In this regard, we suspect that c-Jun N-terminal kinase/Stress activated protein kinase (JNK/SAPK), a major cellular stress response protein induced by oxidative stress, pl... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Alzheimer Disease', 'Antibody Specificity', 'Cerebral Cortex', 'Child', 'Enzyme Activation', 'Hippocampus', 'Humans', 'Immunoblotting', 'Immunohistochemistry', 'Isoenzymes', 'JNK Mitogen-Activated Protein Kinases', 'Middle Aged', 'Mitogen-Activated Protein Kinase 10... | 11,208,906 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['G12.100'], ['A08.186.211.200.885.287.500'], ['M01.060.406'], ['G02.111.263', 'G03.328'], ['A08.186.211.180.405', 'A08.186.211.200.885.287.500.345'], ['B01.050.150.900.649.313... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
The value of including broth cultures as part of a routine culture protocol. | Three hundred seventeen clinical specimens from both superficially and deeply infected sites were prospectively examined to assess the true value of including liquid media as part of the routine culture procedure. All broth cultures were subcultured after overnight incubation onto plate media. The isolates obtained fro... | ['Bacterial Typing Techniques', 'Cell Culture Techniques', 'Culture Media'] | 9,114,388 | [['E01.370.225.875.150.125', 'E05.200.875.150.125'], ['E01.370.225.500.223', 'E05.200.500.265', 'E05.242.223', 'E05.481.500.249'], ['D27.720.470.305', 'E07.206']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Do all fair-skinned Caucasians consider themselves fair? | BACKGROUND: Fair skin color is a risk factor for skin cancer. We aimed to determine whether Caucasians have an accurate perception of their skin color.METHODS: A convenience sample of 341 Caucasian adults in Townsville, Queensland, Australia was asked to categorize the color of their unexposed skin as fair, medium, or ... | ['Adult', 'European Continental Ancestry Group', 'Female', 'Humans', 'Linear Models', 'Male', 'Melanins', 'Queensland', 'Risk Factors', 'Self-Assessment', 'Skin Neoplasms', 'Skin Pigmentation', 'Statistics, Nonparametric'] | 10,564,626 | [['M01.060.116'], ['M01.686.508.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.500', 'E05.318.740.750.425', 'E05.599.835.750', 'N05.715.360.750.530.460', 'N05.715.360.750.695.460', 'N06.850.520.830.500.500', 'N06.850.520.830.750.425'], ['D12.125.072.050.875.379', 'D23.767.620'], ['Z01.639.100... | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Analysis of mutations that uncouple transport from phosphorylation in enzyme IIGlc of the Escherichia coli phosphoenolpyruvate-dependent phosphotransferase system. | Mutations that uncouple glucose transport from phosphorylation were isolated in plasmid-encoded Escherichia coli enzyme IIGlc of the phosphoenolpyruvate-dependent phosphotransferase system (PTS). The uncoupled enzymes IIGlc were able to transport glucose in the absence of the general phosphoryl-carrying proteins of the... | ['Base Sequence', 'Binding Sites', 'Biological Transport', 'Chromosome Mapping', 'Escherichia coli', 'Genes, Bacterial', 'Glucose', 'Kinetics', 'Mutation', 'Phosphoenolpyruvate Sugar Phosphotransferase System', 'Phosphorylation'] | 1,569,016 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G02.111.570.120'], ['G03.143'], ['E05.393.183'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['G05.360.340.024.340.364.249', 'G05.360.340.358.024.249', 'G05.360.340.358.207.249'], ['D09.947.875.359.448'], ['G01.374.661', 'G02.111.490'], ['G05.365... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Implantation of VEGF transfected preadipocytes improves vascularization of fibrin implants on the cylinder chorioallantoic membrane (CAM) model. | The successful substitution or augmentation of soft tissues by implantation of three dimensional cell constructs, consisting of human preadipocytes and fibrin glue as a carrier matrix, requires a rapid and homogeneous vascularization of the whole implant in order to provide a sufficient blood supply of centrally situat... | ['Adipocytes', 'Chorioallantoic Membrane', 'Electroporation', 'Fibrin Tissue Adhesive', 'Genetic Vectors', 'Humans', 'Neovascularization, Physiologic', 'Tissue Engineering', 'Transfection', 'Vascular Endothelial Growth Factor A'] | 17,573,620 | [['A11.329.114'], ['A10.615.284.375', 'A13.350.575', 'A16.331.400'], ['E05.200.500.454', 'E05.242.448', 'E05.301.500'], ['D12.776.124.270.305'], ['G05.360.337'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G09.330.630'], ['E05.481.500.311.500', 'J01.293.069.249.500'], ['E05.393.350.810', 'G05.728.860'], ['D12.64... | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Cimetidine kinetics during resuscitation from burn shock. | Severely burned patients suffer from rapidly changing metabolic and hemodynamic abnormalities that could alter drug kinetics. The kinetics of cimetidine, commonly used in the prophylaxis of acute stress erosions, were studied during fluid resuscitation of 11 patients with mean burn sizes of 45% total body surface area.... | ['Adult', 'Burns', 'Cimetidine', 'Creatinine', 'Female', 'Humans', 'Kidney', 'Kinetics', 'Male', 'Metabolic Clearance Rate', 'Resuscitation', 'Shock, Traumatic', 'p-Aminohippuric Acid'] | 6,744,781 | [['M01.060.116'], ['C26.200'], ['D02.078.370.200', 'D03.383.129.308.130'], ['D03.383.129.308.207'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A05.810.453'], ['G01.374.661', 'G02.111.490'], ['E01.370.225.843', 'E05.200.843', 'G03.490', 'G07.690.595', 'G07.690.725.513'], ['E02.365.647'], ['C23.550.835.888', 'C26... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Mutagenesis of nisin's leader peptide proline strongly modulates export of precursor nisin. | The lantibiotic nisin is produced by Lactococcus lactis as a precursor peptide comprising a 23 amino acid leader peptide and a 34 amino acid post-translationally modifiable core peptide. We previously demonstrated that the conserved FNLD part of the leader is essential for intracellular enzyme-catalyzed introduction of... | ['Amino Acid Sequence', 'Anti-Bacterial Agents', 'Bacterial Proteins', 'Cloning, Molecular', 'Lactococcus lactis', 'Membrane Proteins', 'Mutagenesis', 'Nisin', 'Proline', 'Protein Processing, Post-Translational', 'Protein Sorting Signals', 'Protein Transport', 'Serine Endopeptidases', 'Subtilisins'] | 27,830,473 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D27.505.954.122.085'], ['D12.776.097'], ['E05.393.220'], ['B03.353.750.737.500.400', 'B03.510.400.800.500.400', 'B03.510.550.737.500.400'], ['D12.776.543'], ['G05.558'], ['D04.345.566.582', 'D12.644.641.582', 'D12.776.097.151.700', 'D12.776.543.695.110.700'], ['D12.125.072... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Molecular cloning and functional analysis of porcine SULT1A1 gene and its variant: a single mutation SULT1A1 causes a significant decrease in sulfation activity. | The characterization of the SULT1A1 gene and its variants should have an important impact on the efforts to develop genetic markers to select for low skatole in pigs. Raising intact male pigs would have a significant economic impact on the pork industry; however, the presence of skatole (a major cause of boar taint) in... | ['Amino Acid Sequence', 'Animal Husbandry', 'Animals', 'Arylsulfotransferase', 'Base Sequence', 'Blotting, Western', 'COS Cells', 'Chlorocebus aethiops', 'DNA Primers', 'Gene Library', 'Liver', 'Male', 'Molecular Sequence Data', 'Point Mutation', 'Polymorphism, Single-Stranded Conformational', 'Sequence Alignment', 'Se... | 15,014,971 | [['G02.111.570.060', 'L01.453.245.667.060'], ['J01.040.090'], ['B01.050'], ['D08.811.913.817.400.300'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['A11.251.210.172.500', 'A11.329.228.220'], ['B01.050.15... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Decentration of flexible loop posterior chamber intraocular lenses in a series of 222 postmortem eyes. | Two hundred twenty-two postmortem eyes containing posterior chamber intraocular lenses (IOLs) were analyzed for optic decentration in relationship to lens style, implant duration, and loop fixation site. Decentration values were not affected significantly by either lens style or implant duration. In 33.3% of specimens,... | ['Ciliary Body', 'Equipment Design', 'Humans', 'Lens Capsule, Crystalline', 'Lenses, Intraocular', 'Time Factors', 'Uvea'] | 3,174,001 | [['A09.371.060.160', 'A09.371.894.280'], ['E05.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A09.371.060.500.155'], ['E07.632.500.460', 'E07.695.460'], ['G01.910.857'], ['A09.371.894']] | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Dopamine beta-hydroxylase like immunoreactive cells in the frog taste disc. | We immunohistochemically examined the existence of dopamine beta-hydroxylase (DBH), a noradrenalin (NA)-synthesizing enzyme from dopamine, in the taste disc of frog, Rana catesbeiana. DBH-like immunoreactive cells were located in the intermediate layer in the taste disc; the cells showed an apical process reaching the ... | ['Animals', 'Dopamine beta-Hydroxylase', 'Immunohistochemistry', 'Microscopy, Electron', 'Rana catesbeiana', 'Taste Buds'] | 17,693,417 | [['B01.050'], ['D08.811.682.690.708.292'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512', 'H01.158.201.344.512', 'H01.158.201.486.512', 'H01.181.122.573.512', 'H01.181.122.605.512'], ['E01.370.350.515.402', 'E05.595.402'], [... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
GM2 gangliosidosis in a UK study of children with progressive neurodegeneration: 73 cases reviewed. | AIM: To report the demographic, phenotypic, and time-to-diagnosis characteristics of children with GM2 gangliosidosis referred to the UK study of Progressive Intellectual and Neurological Deterioration.METHOD: Case notification is made via monthly surveillance card, administered by the British Paediatric Surveillance U... | ['Adolescent', 'Child', 'Child, Preschool', 'Cohort Studies', 'Community Health Planning', 'Female', 'Gangliosidoses, GM2', 'Humans', 'Infant', 'Male', 'Neurodegenerative Diseases', 'Pediatrics', 'Retrospective Studies', 'Severity of Illness Index', 'United Kingdom'] | 22,115,551 | [['M01.060.057'], ['M01.060.406'], ['M01.060.406.448'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['N03.349.650.185'], ['C10.228.140.163.100.435.825.300.300', 'C16.320.565.189.435.825.300.300', 'C16.320.565.398.641.803.350.300', 'C16.320.565.595.554.825.300.300', 'C18.452.132.100.43... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
What's in children's backpacks: foods brought from home. | Forty-one percent of elementary schoolchildren bring lunch to school on any given day. Forty-five percent bring snacks. Surprisingly, little is known about the foods and beverages they bring. This cross-sectional analysis of baseline data from the GREEN (Growing Right: Eco-friendly Eating and Nutrition) Project Lunch B... | ['Animals', 'Beverages', 'Child', 'Cross-Sectional Studies', 'Dietary Proteins', 'Edible Grain', 'Feeding Behavior', 'Female', 'Food Quality', 'Fruit', 'Humans', 'Lunch', 'Male', 'Milk', 'Nutrition Assessment', 'Snacks', 'Vegetables'] | 25,037,557 | [['B01.050'], ['G07.203.100', 'J02.200'], ['M01.060.406'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['D12.776.256', 'G07.203.300.428', 'J02.500.428'], ['A18.024.500.750.500', 'B01.650.160.250', 'B01.650.510.250', 'G07.203.300.300.550', 'G07.203.300.775.500', 'J02.500.300.550', 'J02... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
KGF Enhances Oral Epithelial Adhesion and Rete Peg Elongation via Integrins. | Oral epithelial adhesion to the lamina propria underlies the physiologic function of the oral mucosa and contributes to resisting bacterial invasion, preventing body fluid loss, and maintaining routine chewing; thus, understanding the factors that positively influence oral epithelial adhesion is a research topic of gre... | ['Animals', 'Blotting, Western', 'Cell Adhesion', 'Cell Culture Techniques', 'Epithelial Cells', 'Fibroblast Growth Factor 7', 'Integrins', 'Male', 'Mouth Mucosa', 'Oligopeptides', 'Rats', 'Rats, Sprague-Dawley', 'Real-Time Polymerase Chain Reaction'] | 28,732,179 | [['B01.050'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['G04.022'], ['E01.370.225.500.223', 'E05.200.500.265', 'E05.242.223', 'E05.481.500.249'], ['A11.436'], ['D12.644.276.624.170', 'D12.776.467.624.170', 'D23.529.624.170'], ['D12.776.543.750.705.408'], ['A10... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Gender-specific roles for the melanocortin-3 receptor in the regulation of the mesolimbic dopamine system in mice. | The melanocortin-3 receptor (MC3R) and MC4R are known to play critical roles in energy homeostasis. However, the physiological functions of the MC3R remain poorly understood. Earlier reports indicated that the ventral tegmental area (VTA) is one of the highest sites of MC3R expression, and we sought to determine the fu... | ['Animals', 'Appetitive Behavior', 'Behavior, Animal', 'Dopamine', 'Dopaminergic Neurons', 'Female', 'Food Preferences', 'Green Fluorescent Proteins', 'Homeostasis', 'Limbic System', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Mice, Knockout', 'Mice, Mutant Strains', 'Mice, Transgenic', 'Nerve Tissue Proteins', 'Ovariectomy... | 24,605,830 | [['B01.050'], ['F01.145.113.111'], ['F01.145.113'], ['D02.092.211.215.406', 'D02.092.311.342', 'D02.455.426.559.389.657.166.175.342'], ['A08.675.278', 'A11.671.270'], ['F01.145.407.516', 'G07.203.650.353.516'], ['D12.776.532.265'], ['G07.410'], ['A08.186.211.180'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050... | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cyclooxygenase-2 does not mediate late preconditioning induced by activation of adenosine A1 or A3 receptors. | Recent studies have demonstrated that the adenosine A1 receptor agonist 2-chloro-N6-cyclopentyladenosine (CCPA) and the adenosine A3 receptor agonist N6-(3-iodobenzyl)adenosine-5'-N-methyluronamide (IB-MECA) produce a delayed phase of protection against infarction similar to the late phase of ischemic preconditioning (... | ['Animals', 'Cyclooxygenase 2', 'Heart Rate', 'Ischemic Preconditioning, Myocardial', 'Isoenzymes', 'Male', 'Prostaglandin-Endoperoxide Synthases', 'Rabbits', 'Receptor, Adenosine A3', 'Receptors, Purinergic P1'] | 11,454,603 | [['B01.050'], ['D08.811.600.720.750'], ['E01.370.600.875.500', 'G09.330.380.500'], ['E02.592.325', 'E05.516.325'], ['D08.811.348', 'D12.776.800.300'], ['D08.811.600.720', 'D08.811.682.690.708.715'], ['B01.050.150.900.649.313.968.700'], ['D12.776.543.750.695.700.700.300', 'D12.776.543.750.720.700.700.300'], ['D12.776.54... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Development and External Validation of Multiparametric MRI-Derived Nomogram to Predict Risk of Pathologic Upgrade in Patients on Active Surveillance for Prostate Cancer. | OBJECTIVE. The aim of this study was to create, develop, and externally validate a nomogram that predicts pathologic upgrade in patients on active surveillance (AS) for prostate cancer using commonly available clinical and multiparametric MRI (mpMRI) factors. MATERIALS AND METHODS. A consecutive sample of 300 patients ... | ['Aged', 'Aged, 80 and over', 'Humans', 'Male', 'Middle Aged', 'Multiparametric Magnetic Resonance Imaging', 'Neoplasm Grading', 'Nomograms', 'Predictive Value of Tests', 'Prostatic Neoplasms', 'Risk Assessment', 'Watchful Waiting'] | 31,913,073 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.370.350.825.500.755'], ['E01.789.612'], ['E01.789.650', 'E05.318.740.500.625', 'E05.599.835.895', 'G17.582', 'N05.715.360.750.530.530', 'N06.850.520.830.500.625'], ['E05.318.370.800.650', 'N05.715.... | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Does long-term intermittent treatment with glutamine improve the well-being of fed and fasted very old rats? | BACKGROUND: Glutamine is known to have a specific role in very old rats (>25 months of age). For this reason, we have orally supplemented female rats with glutamine (20% of diet protein) intermittently. The treatment started before animals became very old and lasted 5 months. Very old rats were studied in fed state or ... | ['Age Factors', 'Aging', 'Animals', 'Dietary Supplements', 'Disease Models, Animal', 'Fasting', 'Female', 'Glutamate-Ammonia Ligase', 'Glutamine', 'Intestines', 'Muscle, Skeletal', 'Nutritional Status', 'Rats', 'Rats, Wistar'] | 17,947,599 | [['N05.715.350.075', 'N06.850.490.250'], ['G07.345.124'], ['B01.050'], ['G07.203.300.456', 'J02.500.456'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['F01.145.407.400', 'G07.203.650.240.587', 'G07.203.650.353.400'], ['D08.811.464.259.200.600'], ['D12.125.068.330', 'D12.125.095.461', 'D12.125.154.424'], ['A03.556.1... | ['Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Transimination reactions in [b-3C-im][NTf2] ionic liquid. | Compared to conventional molecular solvents, the ionic liquid [b-3C-im][NTf(2)] was found to promote transimination reactions with up to ?100-fold rate enhancement. This rate effect observed at ambient temperature might be explained by the fact that the ionic liquid displays weak Lewis acidity with very low, if any, nu... | ['Amines', 'Bridged Bicyclo Compounds, Heterocyclic', 'Imines', 'Ionic Liquids', 'Kinetics', 'Molecular Structure', 'Stereoisomerism', 'Sulfonamides', 'Temperature'] | 21,505,683 | [['D02.092'], ['D03.605.084'], ['D02.491'], ['D27.720.844.500'], ['G01.374.661', 'G02.111.490'], ['G02.111.570', 'G02.466'], ['G02.607.445.682'], ['D02.065.884', 'D02.886.590.700'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.150.450', 'N06.230.300.100.725.710']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Pravastatin improves endothelial function in arteries used in coronary bypass grafting. | Internal mammary artery (IMA) and radial artery (RA) are the 2 main arterial conduits used in coronary artery bypass grafting (CABG). The aim of this study was to analyze in vitro the vasoreactive properties in both vessels and to investigate the effects of pravastatin incubation on vascular function. IMA and RA rings ... | ['15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid', 'Acetylcholine', 'Aged', 'Coronary Artery Bypass', 'Coronary Artery Disease', 'Endothelium, Vascular', 'Female', 'Humans', 'Hydroxymethylglutaryl-CoA Reductase Inhibitors', 'Male', 'Mammary Arteries', 'Nitroprusside', 'Phenylephrine', 'Postoperative... | 23,429,595 | [['D01.248.497.158.685.750.744.650.500.500', 'D01.339.431.374.744.650.500.500', 'D01.650.550.750.700.650.500.500', 'D02.389.338.638.650.500.500', 'D10.251.355.255.550.025.650.500.500', 'D23.469.050.175.725.025.650.500.500', 'D23.469.700.630.500'], ['D02.092.211.111'], ['M01.060.116.100'], ['E04.100.376.719.332', 'E04.1... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Hypersensitivity of the hypothalamic-pituitary-adrenal axis to naloxone in post-traumatic stress disorder. | Naloxone, which increases endogenous corticotropin-releasing hormone (CRH) release by blocking an inhibitory opioidergic tone on the hypothalamic-pituitary-adrenal (HPA) axis, was administered in a dose-response protocol to seven healthy volunteers and 13 patients with treated posttraumatic stress disorder (PTSD). Six ... | ['Adrenocorticotropic Hormone', 'Adult', 'Analysis of Variance', 'Chromatography, High Pressure Liquid', 'Dose-Response Relationship, Drug', 'Humans', 'Hydrocortisone', 'Hypothalamo-Hypophyseal System', 'Male', 'Middle Aged', 'Naloxone', 'Pilot Projects', 'Pituitary-Adrenal System', 'Psychiatric Status Rating Scales', ... | 8,392,385 | [['D06.472.699.327.935.531.500', 'D06.472.699.631.525.600.531.500', 'D12.644.400.400.935.531.500', 'D12.644.548.365.935.531.500', 'D12.644.548.691.525.690.531.500', 'D12.776.631.650.405.935.531.500'], ['M01.060.116'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['E05.196.181.400.300'], ['G07.690.... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Unilateral pulmonary edema after drainage of a spontaneous pneumothorax: case report and review of the world literature. | Unilateral pulmonary edema has been associated with a variety of clinical disorders including post re-expansion of a pneumothorax. We present a case of unilateral pulmonary edema following chest tube drainage of a spontaneous pneumothorax. A literature review of this complication is reported, the pathophysiology explor... | ['Adult', 'Humans', 'Lung', 'Male', 'Pneumothorax', 'Pressure', 'Pulmonary Edema', 'Pulmonary Surfactants', 'Radiography', 'Suction', 'Time Factors'] | 6,689,613 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A04.411'], ['C08.528.778'], ['G01.374.715'], ['C08.381.742'], ['D27.505.954.796.600'], ['E01.370.350.700'], ['E04.237.890'], ['G01.910.857']] | ['Named Groups [M]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Human dermal fibroblasts escape from the long-term phenocopy of senescence induced by psoralen photoactivation. | We have previously shown that following psoralen photoactivation (PUVA treatment) human dermal fibroblasts undergo long-term growth arrest as well as morphological and functional changes reminiscent of cellular senescence [ 1 ]. In the absence of molecular data on what constitutes normal senescence, it has been difficu... | ['Cell Differentiation', 'Cell Division', 'Cell Line, Transformed', 'Cells, Cultured', 'Cellular Senescence', 'Child', 'Child, Preschool', 'Dermis', 'Fibroblasts', 'Humans', 'Male', 'Matrix Metalloproteinase 1', 'PUVA Therapy', 'Phenotype', 'Skin Diseases', 'Stress, Physiological', 'Telomerase', 'Telomere', 'beta-Galac... | 11,900,490 | [['G04.152'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.251.210.172'], ['A11.251'], ['G04.043'], ['M01.060.406'], ['M01.060.406.448'], ['A17.815.180'], ['A11.329.228'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.277.656.300.480.205.351', 'D08.811.277.656.300.480.525... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Named Groups [M]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Quinacrine-positive neurones in some regions of the guinea-pig brain. | Quinacrine, which has been shown to bind to neurones in the peripheral nervous system, was localized in Purkinje cells in the cerebellum and pyramidal cells in the cerebral cortex and hippocampus of the guinea-pig brain. In the basal ganglia, different populations of fluorescent nerve cell bodies as well as a dense qui... | ['Adenosine Triphosphate', 'Animals', 'Basal Ganglia', 'Binding Sites', 'Brain', 'Cerebellar Nuclei', 'Cerebellum', 'Cerebral Cortex', 'Female', 'Guinea Pigs', 'Hippocampus', 'Male', 'Microscopy, Fluorescence', 'Neurotransmitter Agents', 'Quinacrine'] | 6,145,512 | [['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['B01.050'], ['A08.186.211.200.885.287.249'], ['G02.111.570.120'], ['A08.186.211'], ['A08.186.211.132.810.428.200.337'], ['A08.186.211.132.810.428.200'], ['A08.186.211.200.885.287.500'], ['B01.050.150.900.649.313.992.550'], ['A08.186.211.18... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Discovery of aminobenzyloxyarylamides as ê opioid receptor selective antagonists: application to preclinical development of a ê opioid receptor antagonist receptor occupancy tracer. | Arylphenylpyrrolidinylmethylphenoxybenzamides were found to have high affinity and selectivity for ê opioid receptors. On the basis of receptor binding assays in Chinese hamster ovary (CHO) cells expressing cloned human opioid receptors, (S)-3-fluoro-4-(4-((2-(3-fluorophenyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide (25... | ['Animals', 'Benzamides', 'Brain', 'CHO Cells', 'Chromatography, Liquid', 'Cricetinae', 'Cricetulus', 'HEK293 Cells', 'Humans', 'Pyrrolidines', 'Radioligand Assay', 'Rats', 'Receptors, Opioid, kappa', 'Stereoisomerism', 'Structure-Activity Relationship', 'Tandem Mass Spectrometry'] | 21,958,337 | [['B01.050'], ['D02.065.277', 'D02.241.223.100.100', 'D02.455.426.559.389.127.085'], ['A08.186.211'], ['A11.251.210.200', 'A11.436.155'], ['E05.196.181.400'], ['B01.050.150.900.649.313.992.635.075.250'], ['B01.050.150.900.649.313.992.635.075.250.250'], ['A11.251.210.172.750', 'A11.436.334'], ['B01.050.150.900.649.313.9... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Upregulation of plakophilin-2 and its acquisition to adherens junctions identifies a novel molecular ensemble of cell-cell-attachment characteristic for transformed mesenchymal cells. | In contrast to the desmosome-containing epithelial and carcinoma cells, normal and malignantly transformed cells derived from mesenchymal tissues and tumors are connected only by adherens junctions (AJs) containing N-cadherins and/or cadherin-11, anchored in a cytoplasmic plaque assembled by alpha- and beta-catenin, pl... | ['Adherens Junctions', 'Animals', 'Cell Adhesion', 'Cell Transformation, Neoplastic', 'Cells, Cultured', 'Humans', 'Mesenchymal Stem Cells', 'Mesoderm', 'Mice', 'Plakophilins', 'Up-Regulation'] | 19,551,809 | [['A11.284.149.165.420.020'], ['B01.050'], ['G04.022'], ['C04.697.098.500', 'C23.550.727.098.500'], ['A11.251'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.329.830.500', 'A11.872.590.500'], ['A16.504.660'], ['B01.050.150.900.649.313.992.635.505.500'], ['D12.776.091.750', 'D12.776.220.885'], ['G02.111.905', ... | ['Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Body composition of preschool children and relation to birth weight. | OBJECTIVE: to evaluate the relationship between body composition of preschool children suffering from excess weight and birth weight (BW).METHODS: probabilistic sample, by conglomerates, with 17 daycare centers (of a total of 59) composing a final sample of 479 children. We used Z-score of Body Mass Index (zBMI) ? +1 a... | ['Age Factors', 'Arm', 'Birth Weight', 'Body Composition', 'Brazil', 'Child Day Care Centers', 'Child, Preschool', 'Cluster Analysis', 'Cross-Sectional Studies', 'Female', 'Humans', 'Male', 'Muscle, Skeletal', 'Overweight', 'Pediatric Obesity', 'Prevalence', 'Risk Assessment', 'Skinfold Thickness'] | 24,919,001 | [['N05.715.350.075', 'N06.850.490.250'], ['A01.378.800.075'], ['C23.888.144.186', 'E01.370.600.115.100.160.120.186', 'E05.041.124.160.750.149', 'G07.100.100.160.120.186', 'G07.345.249.314.120.186'], ['G02.111.130', 'G03.180', 'G07.100.049'], ['Z01.107.757.176'], ['J03.160', 'N02.421.143.098'], ['M01.060.406.448'], ['E0... | ['Health Care [N]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Technology, Industry, and Agriculture [J]', 'Named Groups [M]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
Adaptive evolution of metabolic pathways in Drosophila. | The adaptive significance of enzyme variation has been of central interest in population genetics. Yet, how natural selection operates on enzymes in the larger context of biochemical pathways has not been broadly explored. A basic expectation is that natural selection on metabolic phenotypes will target enzymes that co... | ['Adaptation, Physiological', 'Animals', 'Drosophila melanogaster', 'Evolution, Molecular', 'Metabolic Networks and Pathways', 'Molecular Sequence Data'] | 17,379,620 | [['G07.025', 'G16.012.500'], ['B01.050'], ['B01.050.500.131.617.720.500.500.750.310.250.500'], ['G05.045.250', 'G16.075.250'], ['G03.493'], ['L01.453.245.667']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Effects of quadriceps functional exercise with isometric contraction in the treatment of knee osteoarthritis. | OBJECTIVE: This study aims to investigate the effects of a quadriceps isometric contraction exercise method in the treatment of knee osteoarthritis (OA).METHODS: A total of 250 patients with a confirmed diagnosis of knee OA were enrolled. The patients were randomly divided into an exercise treatment test group (128 pat... | ['Aged', 'Biomechanical Phenomena', 'China', 'Disability Evaluation', 'Exercise Therapy', 'Female', 'Humans', 'Isometric Contraction', 'Knee Joint', 'Male', 'Middle Aged', 'Osteoarthritis, Knee', 'Pain Measurement', 'Quadriceps Muscle', 'Recovery of Function', 'Time Factors', 'Treatment Outcome'] | 28,544,687 | [['M01.060.116.100'], ['G01.154.090', 'G01.374.089'], ['Z01.252.474.164'], ['E01.370.400'], ['E02.760.169.063.500.387', 'E02.779.483', 'E02.831.535.483'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G11.427.494.472'], ['A02.835.583.475'], ['M01.060.116.630'], ['C05.550.114.606.500', 'C05.799.613.500'], ['E01.370... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Possible mechanism for the influence of weak magnetic fields on biological systems. | A physical mechanism is suggested for a resonant interaction of weak magnetic fields with biological systems. An ion inside a Ca(2+)-binding protein is approximated by a charged oscillator. A shift in the probability of ion transition between different vibrational energy levels occurs when a combination of static and a... | ['Calcium-Binding Proteins', 'Ions', 'Magnetics'] | 2,039,557 | [['D12.776.157.125'], ['D01.248.497'], ['H01.671.493']] | ['Chemicals and Drugs [D]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Oral Candida flora in a group of Jordanian patients with beta-thalassemia major. | OBJECTIVE: Thalassemic patients present with multiple immune abnormalities that may predispose them to oral Candida, however this has not been investigated. The aim of this study was to assess oral candidal colonization in a group of patients with beta-thalassemia major both qualitatively and quantitatively.STUDY DESIG... | ['Adolescent', 'Candida', 'Carrier State', 'Case-Control Studies', 'Chi-Square Distribution', 'Colony Count, Microbial', 'Female', 'Humans', 'Male', 'Mouth', 'Splenectomy', 'Statistics, Nonparametric', 'beta-Thalassemia'] | 20,123,410 | [['M01.060.057'], ['B01.300.107.795.095', 'B01.300.381.147', 'B01.300.930.176'], ['N06.850.520.169'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['E01.370.225.875.220', 'E05.200.875.220'], [... | ['Named Groups [M]', 'Organisms [B]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Safety and Effectiveness of Transforaminal Epiduroscopic Laser Ablation in Single Level Disc Disease: A Case-Control Study. | BACKGROUND: The non-operative treatment of herniated intervertebral discs has long been a fundamental challenge. A novel technique of laser ablation to ablate the nucleus pulposus under a transforaminal epiduroscope (TELA system, Lutronics, Seoul, Republic of Korea) was recently developed.OBJECTIVE: The purpose of this... | ['Adult', 'Aged', 'Back Pain', 'Case-Control Studies', 'Decompression, Surgical', 'Endoscopy', 'Female', 'Humans', 'Intervertebral Disc Degeneration', 'Intervertebral Disc Displacement', 'Laser Therapy', 'Lasers, Solid-State', 'Lumbar Vertebrae', 'Male', 'Middle Aged', 'Neurosurgical Procedures', 'Prospective Studies',... | 30,508,995 | [['M01.060.116'], ['M01.060.116.100'], ['C23.888.592.612.107'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['E04.188'], ['E01.370.388.250', 'E04.502.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C05.116.900.153'], ['C05.116.900.307', 'C23.300.707.952'], ['E02.594', 'E04.0... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Geographicals [Z]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Placebo-controlled comparison of the efficacy and tolerability of once-daily moxonidine and enalapril in mild-to-moderate essential hypertension. | OBJECTIVES: To compare the antihypertensive efficacy and tolerability of the imidazoline I1 receptor agonist moxonidine, a centrally acting antihypertensive, with the angiotensin converting enzyme inhibitor enalapril.DESIGN: An 8-week, double-blind, randomized, placebo-controlled study involving 140 outpatients with mi... | ['Adult', 'Angiotensin-Converting Enzyme Inhibitors', 'Antihypertensive Agents', 'Blood Pressure', 'Double-Blind Method', 'Drug Administration Schedule', 'Drug Tolerance', 'Enalapril', 'Female', 'Humans', 'Hypertension', 'Imidazoles', 'Imidazoline Receptors', 'Male', 'Middle Aged', 'Receptors, Drug'] | 9,050,976 | [['M01.060.116'], ['D27.505.519.389.745.085'], ['D27.505.954.411.162'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['E02.319.283'], ['G07.690.773.992'], ['D12.644.456.345.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Changes in job satisfaction among doctors in Norway from 2010 to 2017: a study based on repeated surveys. | OBJECTIVE: To assess job satisfaction for different categories of Norwegian doctors from 2010 to 2016-2017.DESIGN: Cross-sectional surveys in 2010, 2012, 2014 and 2016-2017 of partly overlapping samples.SETTING: Norway from 2010 to 2016-2017.PARTICIPANTS: Doctors working in different job positions (hospital doctors, ge... | ['Adult', 'Cross-Sectional Studies', 'Female', 'Humans', 'Job Satisfaction', 'Male', 'Norway', 'Physicians', 'Surveys and Questionnaires'] | 31,501,103 | [['M01.060.116'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.784.692.425'], ['Z01.542.816.374'], ['M01.526.485.810', 'N02.360.810'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
The Medical Student Expectation Scale (MSES): a device for measuring students' expectations of each others' values and behaviours. | A study assessing the differences between institutional and matriculants' expectations of students' attitudes and behaviour was undertaken in 1992 at the Drew/UCLA Medical Education Program (DUMEP) in Los Angeles, California. Responding to a 33-item questionnaire utilizing 5-point Likert scales were 113/122 students in... | ['Attitude of Health Personnel', 'Ethics, Medical', 'Female', 'Humans', 'Male', 'Medically Underserved Area', 'Schools, Medical', 'Social Responsibility', 'Students, Medical', 'United States'] | 8,949,552 | [['F01.100.050', 'N05.300.100'], ['K01.752.566.479.171.132.750', 'N05.350.340.162.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.349.650.340', 'N05.300.450.520'], ['I02.783.495.552', 'N02.278.020.578'], ['F01.829.500.760', 'K01.752.566.869'], ['M01.848.769.602'], ['Z01.107.567.875']] | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Humanities [K]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Named Groups [M]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Multi-omic molecular profiling of lung cancer in COPD. | Chronic obstructive pulmonary disease (COPD) is a known risk factor for developing lung cancer but the underlying mechanisms remain unknown. We hypothesise that the COPD stroma contains molecular mechanisms supporting tumourigenesis.We conducted an unbiased multi-omic analysis to identify gene expression patterns that ... | ['Aged', 'Case-Control Studies', 'Female', 'Gene Expression Profiling', 'Genetic Predisposition to Disease', 'Humans', 'Logistic Models', 'Lung Neoplasms', 'Male', 'Middle Aged', 'Proteome', 'Pulmonary Disease, Chronic Obstructive', 'RNA, Messenger', 'Signal Transduction', 'Transcriptome'] | 29,794,131 | [['M01.060.116.100'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['E05.393.332'], ['C23.550.291.687.500', 'G05.380.355'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.525', 'E05.318.740.600.800.450', 'E05.318.740.750.450', 'E05.599.835.875', 'N05.715.360.750.530... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Genu recurvatum as a complication after total knee arthroplasty. | A 73-year-old female patient underwent total knee arthroplasty for arthrosis. After surgery, recurvatum instability over 55 degrees occurred. Two years later, primary endoprosthesis was removed and a revision endoprosthesis implanted. However, complete deformity occurred again. Two years later, the thickest revision po... | ['Aged', 'Arthroplasty, Replacement, Knee', 'Female', 'Humans', 'Joint Deformities, Acquired', 'Knee Joint', 'Knee Prosthesis', 'Recurrence', 'Reoperation'] | 23,115,953 | [['M01.060.116.100'], ['E04.555.110.110.115', 'E04.650.110.115', 'E04.680.101.110.115'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C05.550.515'], ['A02.835.583.475'], ['E07.695.400.410'], ['C23.550.291.937'], ['E04.690']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Keep music live: music and the alleviation of apathy in dementia subjects. | BACKGROUND: A recent Cochrane report concluded that more and better quality research is required to investigate the effectiveness of music therapy in reducing problems in behavioral, social, emotional and cognitive domains in patients with dementia. This randomized placebo-controlled trial with blinded observer rater a... | ['Aged', 'Aged, 80 and over', 'Alzheimer Disease', 'England', 'Female', 'Homes for the Aged', 'Humans', 'Male', 'Motivation', 'Music Therapy', 'Nursing Homes', 'Social Behavior Disorders', 'Social Environment'] | 16,805,928 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['Z01.542.363.300'], ['J03.775.462', 'N02.278.825.462'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.658', 'F01.752.543.500.750'], ['E02.190.888.500', 'E02.760.169.063.500.440', 'E02.831.440', 'F04.7... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
No association of spastic paraparesis genes in PSEN1 Alzheimer's disease with spastic paraparesis. | Familial Alzheimer's disease due to presenilin 1 (PSEN1) mutations shows considerable phenotypic variability with differences in neuropathology and neurological symptoms. Spastic paraparesis is a common neurological phenotype associated with Alzheimer's disease arising from PSEN1 mutations. To investigate whether known... | ['Adult', 'Alzheimer Disease', 'DNA Mutational Analysis', 'Female', 'Gene Deletion', 'Genetic Markers', 'Genetic Predisposition to Disease', 'Genetic Testing', 'Genetic Variation', 'Genotype', 'Humans', 'Male', 'Middle Aged', 'Mutation', 'Paraparesis, Spastic', 'Pedigree', 'Phenotype', 'Presenilin-1'] | 17,632,280 | [['M01.060.116'], ['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['E05.393.760.700.300'], ['G05.365.590.762.320', 'G05.558.800.320'], ['D23.101.387', 'G05.695.450'], ['C23.550.291.687.500', 'G05.380.355'], ['E01.370.225.562', 'E05.200.562', 'E05.393.435', 'N02.421.308.430', 'N02.421.726.233.221'], ['G05... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Analysis of the airway registry from an academic emergency department in South Africa. | BACKGROUND: Airway management is an essential skill for doctors working in the emergency department (ED). Safety and efficacy are crucial to its success. Analysis of an airway registry can provide feedback that can be used for quality improvement purposes.OBJECTIVES: To examine the first airway registry from an ED in S... | ['Adult', 'Aged', 'Airway Management', 'Emergency Service, Hospital', 'Female', 'Fluid Therapy', 'Humans', 'Intubation, Intratracheal', 'Laryngoscopy', 'Male', 'Middle Aged', 'Oxygen Inhalation Therapy', 'Registries', 'Retrospective Studies', 'South Africa'] | 32,880,559 | [['M01.060.116'], ['M01.060.116.100'], ['E02.041'], ['N02.278.216.500.968.336', 'N02.421.297.195', 'N04.452.442.452.422.336'], ['E02.319.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.041.500', 'E02.585.578', 'E05.497.578'], ['E01.370.386.460', 'E01.370.388.250.525', 'E04.502.250.525', 'E04.580.373'], ['... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Thrombospondin 2 gene expression is correlated with decreased vascularity in non-small cell lung cancer. | Stromal vascularity is thought to be a major factor involved in the progression of carcinoma. However, the crucial mechanisms of vascularization in the stroma are not well understood. Vascularity could be regulated by various cytokines produced by neoplastic or stromal cells in carcinoma. Thrombospondin (TSP) has an in... | ['Carcinoma, Non-Small-Cell Lung', 'Gene Expression', 'Humans', 'Lung Neoplasms', 'Neoplasm Proteins', 'Prognosis', 'Thrombospondin 1', 'Thrombospondins'] | 9,676,856 | [['C04.588.894.797.520.109.220.249', 'C08.381.540.140.500', 'C08.785.520.100.220.500'], ['G05.297'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['D12.776.624'], ['E01.789'], ['D12.776.395.550.895.800', 'D12.776.543.550.895.800'], ['D12.776.395.550.895', 'D12.... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Post-marketing survey on the safety of sublingual immunotherapy in children below the age of 5 years. | BACKGROUND: The age below 5 years is considered a prudential limit for immunotherapy in view of the possible severity of side-effects. Sublingual immunotherapy (SLIT) seems to be safe, but no study in very young children is available. We performed a safety post-marketing surveillance study in children below 5 years.MET... | ['Administration, Sublingual', 'Allergens', 'Alternaria', 'Asthma', 'Child, Preschool', 'Drug Administration Schedule', 'Female', 'Humans', 'Immunotherapy, Active', 'Male', 'Parietaria', 'Product Surveillance, Postmarketing', 'Pyroglyphidae', 'Respiratory Hypersensitivity', 'Rhinitis'] | 15,898,975 | [['E02.319.267.100.878'], ['D23.050.063'], ['B01.300.381.075'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['M01.060.406.448'], ['E02.319.283'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.095.465.425.400.530', 'E05.478.550.600'], ['B01.650.940.800.575.912.250.859.937.937.777']... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Inducible cardiac arrhythmias caused by enhanced â1-adrenergic autoantibody expression in the rabbit. | Previous studies demonstrated burst pacing and intravenous infusion of ACh induced sustained atrial tachycardia when rabbits were immunized to produce â2-adrenergic receptor (â2AR)-activating autoantibodies. The objective of this study was to examine the arrhythmogenic effect of â1-adrenergic receptor (â1AR)-activating... | ['Acetylcholine', 'Animals', 'Arrhythmias, Cardiac', 'Autoantibodies', 'Heart Rate', 'Rabbits', 'Receptors, Adrenergic, beta-1'] | 24,271,491 | [['D02.092.211.111'], ['B01.050'], ['C14.280.067', 'C23.550.073'], ['D12.776.124.486.485.114.323', 'D12.776.124.790.651.114.323', 'D12.776.377.715.548.114.323'], ['E01.370.600.875.500', 'G09.330.380.500'], ['B01.050.150.900.649.313.968.700'], ['D12.776.543.750.670.300.300.340.100', 'D12.776.543.750.695.150.300.340.700'... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Indoleamine 2,3-dioxygenase 1 is a lung-specific innate immune defense mechanism that inhibits growth of Francisella tularensis tryptophan auxotrophs. | Upon microbial challenge, organs at various anatomic sites of the body employ different innate immune mechanisms to defend against potential infections. Accordingly, microbial pathogens evolved to subvert these organ-specific host immune mechanisms to survive and grow in infected organs. Francisella tularensis is a bac... | ['Animals', 'Biosynthetic Pathways', 'Cell Line', 'Colony Count, Microbial', 'Female', 'Francisella tularensis', 'Gene Expression Profiling', 'Indoleamine-Pyrrole 2,3,-Dioxygenase', 'Lung', 'Macrophages', 'Mice', 'Mice, Inbred C57BL', 'Mice, Knockout', 'Oligonucleotide Array Sequence Analysis', 'Spleen', 'Streptococcus... | 20,385,761 | [['B01.050'], ['G02.111.098', 'G03.493.100'], ['A11.251.210'], ['E01.370.225.875.220', 'E05.200.875.220'], ['B03.440.400.425.340.590', 'B03.660.250.200.750'], ['E05.393.332'], ['D08.811.682.690.416.333'], ['A04.411'], ['A11.329.372', 'A11.627.482', 'A11.733.397', 'A15.382.670.522', 'A15.382.680.397'], ['B01.050.150.900... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Biological significance of amino acids deletion in NA stalk of H5N1 avian influenza virus]. | It has been reported that NA gene of some H1N1 Influenza A virus strains isolated since 1933 is characterized by a deletion of 11 to 16 amino acids in the stalk. The spontaneous mutant in NA stalk of H1N1 virus lacks enzyme activity with large substrate (fetuin) but not with small substrate (sialyllactose). Recently, H... | ['Animals', 'Cell Line', 'Chick Embryo', 'Dogs', 'Erythrocytes', 'Guinea Pigs', 'Influenza A Virus, H1N1 Subtype', 'Influenza A Virus, H5N1 Subtype', 'Neuraminidase', 'Recombination, Genetic', 'Sequence Deletion', 'Viral Proteins'] | 17,037,051 | [['B01.050'], ['A11.251.210'], ['A13.350.150', 'A16.331.200'], ['B01.050.150.900.649.313.750.250.216.200'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['B01.050.150.900.649.313.992.550'], ['B04.820.480.968.405.400.214'], ['B04.820.480.968.405.400.500'], ['D08.811.277.450.692'], ['G05.728'], ['G05.365.590.762', ... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Modeling dense-colloid and virus cotransport in three-dimensional porous media. | A three-dimensional numerical model was developed to investigate the simultaneous transport (cotransport) of dense colloids and viruses in homogeneous, water saturated, porous media with horizontal uniform flow. The dense colloids are assumed to exist in two different phases: suspended in the aqueous phase, and attache... | ['Colloids', 'Gravitation', 'Groundwater', 'Hydrology', 'Models, Theoretical', 'Porosity', 'Viruses'] | 26,071,628 | [['D20.280', 'D26.255.165'], ['G01.060.350'], ['G01.311.355'], ['H01.158.273.248.875', 'H01.277.249.875', 'J01.293.622'], ['E05.599'], ['G01.374.710'], ['B04']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Absence of truncating BRIP1 mutations in chromosome 17q-linked hereditary prostate cancer families. | BACKGROUND: In a genome-wide scan (GWS) of 175 multiplex prostate cancer (PCa) families from the University of Michigan Prostate Cancer Genetics Project (PCGP), linkage was observed to markers on chromosome 17q21-24, a region that includes two breast cancer susceptibility genes, BRCA1 and BRIP1. BRIP1 is a Fanconi anae... | ['Aged', 'Chromosomes, Human, Pair 17', 'DNA-Binding Proteins', 'Fanconi Anemia Complementation Group Proteins', 'Female', 'Genetic Linkage', 'Humans', 'Male', 'Middle Aged', 'Mutation', 'Polymorphism, Single Nucleotide', 'Prostatic Neoplasms', 'RNA Helicases'] | 19,935,797 | [['M01.060.116.100'], ['A11.284.187.520.300.415.425', 'G05.360.162.520.300.415.425'], ['D12.776.260'], ['D12.776.313'], ['G05.348'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['G05.365.590'], ['G05.365.795.598'], ['C04.588.945.440.770', 'C12.294.260.750', 'C12.294.565.625', 'C12.758.409.750'... | ['Named Groups [M]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Reduced nicotinamide adenine dinucleotide oxidase activity in membranes and cytoplasm of Acholeplasma laidlawii and Mycoplasma mycoides subsp. capri. | The properties of the membrane-bound reduced nicotinamide adenine dinucleotide (NADH) oxidase of Acholeplasma laidlawii were compared with those of the corresponding cytoplasmic activity of Mycoplasma mycoides subsp. capri. The striking differences in pH optima, susceptibility to inhibitors and detergents, and heat ina... | ['Acholeplasma laidlawii', 'Chloromercuribenzoates', 'Cytoplasm', 'Deoxycholic Acid', 'Dinitrophenols', 'Electrophoresis, Polyacrylamide Gel', 'Hot Temperature', 'Hydrogen-Ion Concentration', 'Membranes', 'Mycoplasma mycoides', 'NADH, NADPH Oxidoreductases', 'Polyethylene Glycols', 'Subcellular Fractions', 'Sulfhydryl ... | 11,208 | [['B03.440.860.074.150.500'], ['D02.241.223.100.200.311', 'D02.241.223.100.500.261', 'D02.455.426.559.389.127.250.311', 'D02.455.426.559.389.127.500.261', 'D02.691.750.740.644.261'], ['A11.284.430.214'], ['D04.210.500.105.225.272', 'D04.210.500.221.430.342'], ['D02.455.426.559.389.657.566.304', 'D02.640.743.304'], ['E0... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
[Evaluation of long-term occupational exposure to dust and its effect on health during production of ceramic tiles]. | A medical examination has been carried out of 500 workers (290 men and 210 women) of a ceramic plates plant. Also, the measurements of dust concentrations were made at some standard work places . In the materials used for manufacturing the plates crystalline phases and the content of free crystalline silica were determ... | ['Adult', 'Air Pollutants, Occupational', 'Ceramics', 'Chronic Disease', 'Dust', 'Female', 'Household Articles', 'Humans', 'Male', 'Middle Aged', 'Occupations', 'Poland', 'Sex Factors', 'Silicon Dioxide', 'Silicosis', 'Smoking', 'Time Factors'] | 1,321,940 | [['M01.060.116'], ['D27.888.284.101.268'], ['J01.637.153'], ['C23.550.291.500'], ['D20.633.222'], ['J01.494'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['N01.824.547'], ['Z01.542.248.679'], ['N05.715.350.675', 'N06.850.490.875'], ['D01.578.750', 'D01.650.550.825', 'D01.837.725'], ['C08.381.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
Global Hypomethylation (LINE-1) and Gene-Specific Hypermethylation (GSTP1) on Initial Negative Prostate Biopsy as Markers of Prostate Cancer on a Rebiopsy. | PURPOSE: Men at risk of missed prostate cancer on a negative biopsy often undergo a rebiopsy. We evaluated whether global hypomethylation, measured through LINE-1 methylation, and GSTP1 hypermethylation on a negative biopsy are associated with subsequent prostate cancer diagnosis.EXPERIMENTAL DESIGN: We performed a cas... | ['Biomarkers, Tumor', 'Biopsy', 'Case-Control Studies', 'DNA Methylation', 'Glutathione S-Transferase pi', 'Humans', 'Long Interspersed Nucleotide Elements', 'Male', 'Neoplasm Grading', 'Prostate', 'Prostatic Neoplasms'] | 26,475,336 | [['D23.101.140'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['G02.111.035.538.161', 'G02.111.218', 'G03.059.538.161', 'G05.206'], ['D08.811.... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Tumor necrosis factor in the serum of patients with systemic lupus erythematosus. | In view of recent data demonstrating defective production of tumor necrosis factor alpha (TNF cachectin) in murine autoimmune lupus nephritis, we studied the serum levels of TNF in 22 patients with systemic lupus erythematosus (SLE), using a specific radioimmunoassay. Patients with SLE had either normal or slightly ele... | ['Adolescent', 'Adult', 'Aged', 'Autoantibodies', 'C-Reactive Protein', 'DNA', 'Female', 'Follow-Up Studies', 'Humans', 'Infections', 'Lupus Erythematosus, Systemic', 'Male', 'Middle Aged', 'Radioimmunoassay', 'Time Factors', 'Tumor Necrosis Factor-alpha'] | 2,920,050 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['D12.776.124.486.485.114.323', 'D12.776.124.790.651.114.323', 'D12.776.377.715.548.114.323'], ['D12.776.034.145', 'D12.776.124.050.120', 'D12.776.124.486.157'], ['D13.444.308'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.3... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Thoracic inflammatory pseudotumors : A rare differential diagnosis]. | BACKGROUND: Inflammatory pseudotumors are a rare and in the main benign tumor entity but infiltrative growth, recurrence and metastases are described. Generally, a complete resection is needed to exclude lung cancer. This study analyzed our data and experiences with this rare tumor entity.MATERIAL AND METHODS: We perfo... | ['Adult', 'Aged', 'Diagnosis, Differential', 'Female', 'Granuloma, Plasma Cell', 'Humans', 'Lung Neoplasms', 'Male', 'Middle Aged', 'Neoplasm Recurrence, Local', 'Retrospective Studies'] | 29,305,634 | [['M01.060.116'], ['M01.060.116.100'], ['E01.171'], ['C23.550.382.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['M01.060.116.630'], ['C04.697.655', 'C23.550.727.655'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', ... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Risks, stigma and Honduran Gar?funa conceptions of HIV/AIDS. | The HIV/AIDS epidemic along Honduras' north coast has intensified in recent years and become particularly severe in Gar?funa communities. Based on a qualitative study in the community of Las Espinas and comparison with results from an earlier knowledge, attitudes, beliefs and practices survey, this article explores Gar... | ['Adolescent', 'Adult', 'Child', 'Culture', 'Female', 'HIV Infections', 'Health Knowledge, Attitudes, Practice', 'Honduras', 'Humans', 'Male', 'Middle Aged', 'Prejudice', 'Qualitative Research', 'Safe Sex', 'Sexual Behavior'] | 15,144,758 | [['M01.060.057'], ['M01.060.116'], ['M01.060.406'], ['I01.076.201.450', 'I01.880.853.100'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['F01.100.150.500', 'N05.300.150.410'], ['Z01.107.169.534'], ['B01.050.150.900.649.313.988.400.112.400.4... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Geographicals [Z]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Bowel Sonography and MR Enterography in Children. | OBJECTIVE: The objective of this study was to assess the diagnostic agreement between bowel sonography and MR enterography in children with suspected or confirmed inflammatory bowel disease (IBD).SUBJECTS AND METHODS: We prospectively studied 33 children undergoing clinically indicated MR enterography. Bowel sonography... | ['Adolescent', 'Child', 'Female', 'Humans', 'Inflammatory Bowel Diseases', 'Magnetic Resonance Imaging', 'Male', 'Prospective Studies', 'Sensitivity and Specificity', 'Transducers', 'Ultrasonography'] | 26,700,349 | [['M01.060.057'], ['M01.060.406'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C06.405.205.731', 'C06.405.469.432'], ['E01.370.350.825.500'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700', 'N05.71... | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Acid-shock responses in Staphylococcus aureus investigated by global gene expression analysis. | A general overview is presented of the changes in the genetic expression along a time curve through the first 20 min after acidification to pH 4.5 of exponentially growing cultures of the food pathogenic strain Staphylococcus aureus 50583. A newly developed method for statistical significance testing was used to detect... | ['Acids', 'Adaptation, Physiological', 'Bacterial Proteins', 'Down-Regulation', 'Gene Expression Regulation, Bacterial', 'Gene Expression Regulation, Enzymologic', 'Hydrogen-Ion Concentration', 'Oxidative Stress', 'Staphylococcus aureus', 'Up-Regulation', 'Urease'] | 17,600,073 | [['D01.029'], ['G07.025', 'G16.012.500'], ['D12.776.097'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['G05.308.300'], ['G05.308.320'], ['G02.300'], ['G03.673', 'G07.775.750'], ['B03.300.390.400.800.750.100', 'B03.353.500.750.750.100', 'B03.510.100.750.750.100', 'B03.510.400.790.750.100'], ['G02.111.905', 'G05.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Antiviral effects of antisense morpholino oligomers in murine coronavirus infection models. | The recent emergence of novel pathogenic human and animal coronaviruses has highlighted the need for antiviral therapies that are effective against a spectrum of these viruses. We have used several strains of murine hepatitis virus (MHV) in cell culture and in vivo in mouse models to investigate the antiviral character... | ['Animals', 'Antiviral Agents', 'Chlorocebus aethiops', 'Coronavirus Infections', 'Disease Models, Animal', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Morpholines', 'Murine hepatitis virus', 'Oligonucleotides, Antisense', 'Vero Cells', 'Viral Load'] | 17,344,287 | [['B01.050'], ['D27.505.954.122.388'], ['B01.050.150.900.649.313.988.400.112.199.120.126.110'], ['C01.925.782.600.550.200'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420'], ['D03.383.533.640']... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Toxigenicity of culture filtrates of Salmonella enteritidis isolates on three mammalian cell lines. | Culture filtrates of 28 Salmonella enteritidis isolates were tested for toxicity on Vero-, CHO-, and human foreskin fibroblast (HFF) cells. Cytopathic effects on HFF cells were extensive, and were observed even with some filtrates diluted 1:256. Vero cells showed effects with filtrates diluted up to 1:16, and CHO cells... | ['Animals', 'CHO Cells', 'Cell Death', 'Cell Line', 'Chlorocebus aethiops', 'Cricetinae', 'Cytotoxins', 'Humans', 'Salmonella enteritidis', 'Siderophores', 'Vero Cells'] | 7,553,360 | [['B01.050'], ['A11.251.210.200', 'A11.436.155'], ['G04.146'], ['A11.251.210'], ['B01.050.150.900.649.313.988.400.112.199.120.126.110'], ['B01.050.150.900.649.313.992.635.075.250'], ['D27.888.569.213'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B03.440.450.425.800.200.300', 'B03.660.250.150.710.160.160'], ['D2... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Toxicity of silver and copper to Cucurbita pepo: differential effects of nano and bulk-size particles. | The phytotoxicity of bulk and nanoparticle Cu and Ag was directly compared. NP Ag reduced biomass and transpiration by 66-84% when compared with bulk Ag. The Ag ion concentration was 4.4-10-times greater in NP than bulk particle solutions. The Cu ion concentration was 1.4-4.4-times greater in bulk than NP amended solut... | ['Biomass', 'Copper', 'Cucurbita', 'Hydroponics', 'Metal Nanoparticles', 'Particle Size', 'Plant Transpiration', 'Silver'] | 22,887,766 | [['G16.500.275.157.100', 'N06.230.124.100'], ['D01.268.556.195', 'D01.268.956.170', 'D01.552.544.195'], ['B01.650.940.800.575.912.250.300.222'], ['J01.040.581'], ['J01.637.512.600.500'], ['G02.712'], ['G15.713'], ['D01.268.556.812', 'D01.268.956.843', 'D01.552.544.812']] | ['Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
A unified in vitro test system for the assessment of tight junction modulators. | Tight junction (TJ) modulation is a promising approach for improving drug bioavailability by enhancing the absorption of active pharmaceutical ingredients. However, the application of many different test methods to determine the efficacy of new TJ modulators (TJMs) or to assess different compounds is accompanied by a l... | ['Animals', 'Biological Availability', 'Cell Line', 'Cell Survival', 'Dogs', 'Excipients', 'Madin Darby Canine Kidney Cells', 'Mannitol', 'Permeability', 'Pharmaceutical Preparations', 'Tight Junctions'] | 31,278,992 | [['B01.050'], ['G03.787.151', 'G07.690.725.129'], ['A11.251.210'], ['G04.346'], ['B01.050.150.900.649.313.750.250.216.200'], ['D26.650.700.419', 'D27.720.744.770.419'], ['A11.251.210.827', 'A11.436.589'], ['D02.033.800.609', 'D09.853.609'], ['G02.723'], ['D26'], ['A11.284.149.165.420.820']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Sporotrichosis. | Five cases of cutaneous sporotrichosis were seen at the Stanford University Department of Dermatology from 1966 to 1977, where the disease was previously unreported. The possibility of sporotrichosis should be considered when suppurative cutaneous lesions do not respond to antibacterial agents. Skin biopsy of sporotric... | ['Adult', 'Aged', 'Child, Preschool', 'Dermatomycoses', 'Female', 'Fluorescent Antibody Technique', 'Hot Temperature', 'Humans', 'Male', 'Middle Aged', 'Potassium Iodide', 'Sporothrix', 'Sporotrichosis'] | 389,841 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Two Cases of Difficult-to-Treat Acute Epidural Hematoma and a Review of Decompressive Craniectomy with Hematoma Evacuation]. | INTRODUCTION: Decompressive craniectomy(DC)with craniotomy for acute epidural hematoma(AEDH)removal is controversial. Here, we summarized two difficult AEDH cases where DC was performed. CASE 1:A 26-year-old man sustained a head injury in a bicycle accident, with a Japan Coma Scale(JCS)score of 200, right pupil mydrias... | ['Adolescent', 'Adult', 'Craniocerebral Trauma', 'Craniotomy', 'Hematoma, Epidural, Cranial', 'Humans', 'Male', 'Tomography, X-Ray Computed'] | 29,567,873 | [['M01.060.057'], ['M01.060.116'], ['C10.900.300', 'C26.915.300'], ['E04.525.190'], ['C10.228.140.300.535.450.300', 'C10.900.300.837.300', 'C14.907.253.573.400.400', 'C23.550.414.838.349', 'C23.550.414.913.400', 'C26.915.300.490.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.350.810', 'E01.370.35... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Pitfalls of PCR-based genotyping in patients with 21-hydroxylase deficiency. | Mutation analysis of CYP21A2 gene was performed in seven patients with congenital adrenal hyperplasia (CAH) by combining differential long template polymerase chain reaction (PCR) amplification and amplified created restriction site (ACRS) methods. All mutations were identified, including five alleles of deletions, thr... | ['Adrenal Hyperplasia, Congenital', 'DNA Mutational Analysis', 'Female', 'Genetic Carrier Screening', 'Genetic Linkage', 'Genotype', 'Humans', 'Polymerase Chain Reaction'] | 11,431,859 | [['C12.706.316.090.500', 'C13.351.875.253.090.500', 'C16.131.939.316.129.500', 'C16.320.033', 'C16.320.565.925.249', 'C18.452.648.925.249', 'C19.053.440', 'C19.391.119.090.500'], ['E05.393.760.700.300'], ['E01.370.225.562.250', 'E05.200.562.250', 'E05.393.435.250', 'N02.421.308.200', 'N02.421.726.233.221.250'], ['G05.3... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Effect of follicle cell autophagy on gonadal development of triploid female rainbow trout (Oncorhynchus mykiss). | Autophagy is a cellular process which occurs in eukaryotic cells. To study the mechanism regulating polyploid fish growth and development is of significance in genetic, because of its growth advantages and economic values. This study focused on triploid female rainbow trout (RBT) which discusses the effects of autophag... | ['Animals', 'Antibodies', 'Autophagy', 'Female', 'Fish Proteins', 'Gene Expression Regulation, Developmental', 'Oncorhynchus mykiss', 'Ovarian Follicle', 'Recombinant Proteins', 'Sex Differentiation', 'Triploidy'] | 29,086,110 | [['B01.050'], ['D12.776.124.486.485.114', 'D12.776.124.790.651.114', 'D12.776.377.715.548.114'], ['G04.011'], ['D12.776.325'], ['G05.308.310'], ['B01.050.150.900.493.817.750.825.580.600'], ['A05.360.319.114.630.535', 'A06.300.312.497.535'], ['D12.776.828'], ['G07.345.500.325.377.843', 'G07.345.750.500', 'G08.686.841.50... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of apoE gene polymorphism on Lp(a) concentrations depend on the size of apo(a): a study of 466 white men. | Polymorphisms in the genes for the low-density lipoprotein (LDL) receptor ligands, apolipoprotein E (apoE), and apolipoprotein B (apoB) are associated with variation in plasma levels of LDL cholesterol. Lp(a) lipoprotein(a) [Lp(a)] is LDL in which apoB is attached to a glycoprotein called apolipoprotein(a) [apo(a)]. Ap... | ['Apolipoproteins A', 'Apolipoproteins E', 'Body Weight', 'Cholesterol', 'Coronary Disease', 'European Continental Ancestry Group', 'Humans', 'Lipoprotein(a)', 'Lipoproteins, LDL', 'Male', 'Molecular Weight', 'Phenotype', 'Plasminogen Activators', 'Polymorphism, Genetic', 'Polymorphism, Restriction Fragment Length', 'R... | 8,956,154 | [['D10.532.091.200', 'D12.776.070.400.200', 'D12.776.521.120.200'], ['D10.532.091.500', 'D12.776.070.400.500', 'D12.776.521.120.500'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Named Groups [M]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Ureterocystoneostomy in urinary tuberculosis: a personal technique. | A personal surgical technique in the treatment of the tuberculous stenosis of the juxtavesical and intramural ureter, is described. 62 patients suffering from tuberculosis of the urinary tract underwent surgical treatment. 42 of these cases presented with ureteral stenosis: 14 were submitted to ureterocystoneostomy (UC... | ['Constriction, Pathologic', 'Female', 'Humans', 'Methods', 'Postoperative Complications', 'Suture Techniques', 'Tuberculosis, Urogenital', 'Ureter', 'Ureteral Diseases', 'Urinary Bladder'] | 6,378,829 | [['C23.300.287'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.581'], ['C23.550.767'], ['E04.987.775'], ['C01.150.252.410.040.552.846.944', 'C12.672', 'C13.351.750'], ['A05.810.776'], ['C12.777.725', 'C13.351.968.725'], ['A05.810.890']] | ['Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Key steps in ERAD of luminal ER proteins reconstituted with purified components. | Misfolded proteins of the endoplasmic reticulum (ER) are retrotranslocated into the cytosol, polyubiquitinated, and degraded by the proteasome, a process called ER-associated protein degradation (ERAD). Here, we use purified components from Saccharomyces cerevisiae to analyze the mechanism of retrotranslocation of lumi... | ['Adenosine Triphosphatases', 'Cell Cycle Proteins', 'Endopeptidases', 'Endoplasmic Reticulum', 'Endoplasmic Reticulum-Associated Degradation', 'Protein Folding', 'Proteolipids', 'Saccharomyces cerevisiae', 'Saccharomyces cerevisiae Proteins', 'Ubiquitin-Protein Ligases', 'Ubiquitination', 'Valosin Containing Protein'] | 25,215,493 | [['D08.811.277.040.025'], ['D12.776.167'], ['D08.811.277.656.300'], ['A11.284.430.214.190.875.248'], ['G02.111.660.871.790.600.962.500', 'G02.111.691.600.850.500', 'G03.734.871.790.600.850.500', 'G05.308.670.600.850.500'], ['G01.154.651', 'G02.111.688'], ['D10.570.780', 'D12.776.816'], ['B01.300.107.795.785.800', 'B01.... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Development and validation of a prognostic gene-expression signature for lung adenocarcinoma. | Although several prognostic signatures have been developed in lung cancer, their application in clinical practice has been limited because they have not been validated in multiple independent data sets. Moreover, the lack of common genes between the signatures makes it difficult to know what biological process may be r... | ['Adenocarcinoma', 'Adenocarcinoma of Lung', 'Adult', 'Aged', 'Aged, 80 and over', 'Chemotherapy, Adjuvant', 'Cluster Analysis', 'Cohort Studies', 'Female', 'Gene Expression Regulation, Neoplastic', 'Genes, Neoplasm', 'Humans', 'Lung Neoplasms', 'Male', 'Middle Aged', 'Models, Genetic', 'Multivariate Analysis', 'Progno... | 22,970,185 | [['C04.557.470.200.025'], ['C04.557.470.200.025.022', 'C04.588.894.797.520.055'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E02.186.170', 'E02.319.170'], ['E05.318.740.250', 'N05.715.360.750.200', 'N06.850.520.830.250'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Influence of socioeconomic factors on medically unnecessary ambulance calls. | BACKGROUND: Unnecessary ambulance use has become a socioeconomic problem in Japan. We investigated the possible relations between socioeconomic factors and medically unnecessary ambulance calls, and we estimated the incremental demand for unnecessary ambulance use produced by socioeconomic factors.METHODS: We conducted... | ['Adult', 'Age Factors', 'Aged', 'Aged, 80 and over', 'Ambulances', 'Automobiles', 'Decision Making', 'Emergency Medical Service Communication Systems', 'Female', 'Health Services Misuse', 'Health Services Needs and Demand', 'Humans', 'Japan', 'Male', 'Middle Aged', 'Regression Analysis', 'Sex Factors', 'Socioeconomic ... | 17,655,772 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['J01.937.500.050', 'N02.421.297.879.100'], ['J01.937.500.100'], ['F02.463.785.373'], ['N02.421.297.058'], ['N02.421.380', 'N05.300.150.395'], ['N03.349.380.420', 'N05.300.450'], ['B01.050.150.900.649.313.988.400.112... | ['Named Groups [M]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
Exposure duration and line length: an analogy to the Broca-Sulzer effect in perception of extent? | For 30 undergraduates, brief exposures were shown to increase the apparent length of a line. This enhancement of length diminished as duration of exposure increased, creating an illusion of line length that resembles the Broca-Sulzer brightness anomaly. | ['Humans', 'Illusions', 'Optical Illusions', 'Photic Stimulation', 'Size Perception'] | 7,208,241 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.597.606.762.400', 'C23.888.592.604.764.400', 'F01.700.750.400', 'F02.463.593.446'], ['F02.463.593.446.659'], ['E05.723.729'], ['F02.463.593.725', 'F02.463.593.778.794']] | ['Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Lead contamination in American woodcock (Scolopax minor) from Wisconsin. | An initial survey of lead levels in American woodcock (Scolopax minor) from Wisconsin was conducted in 1998 using wing bones from hunter-donated woodcock. The results of this initial survey indicated that young-of-year woodcock were accumulating extremely high levels of lead in their bones. Similar collections were mad... | ['Animals', 'Bone and Bones', 'Charadriiformes', 'Environmental Monitoring', 'Environmental Pollutants', 'Lead', 'Liver', 'Porphobilinogen Synthase', 'Wisconsin'] | 16,132,412 | [['B01.050'], ['A02.835.232', 'A10.165.265'], ['B01.050.150.900.248.150'], ['N06.850.460.350.080', 'N06.850.780.375'], ['D27.888.284'], ['D01.268.556.435', 'D01.552.544.435'], ['A03.620'], ['D08.811.520.241.300.550'], ['Z01.107.567.875.350.900', 'Z01.107.567.875.510.900']] | ['Organisms [B]', 'Anatomy [A]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Geographicals [Z]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Counteracting quasispecies adaptability: extinction of a ribavirin-resistant virus mutant by an alternative mutagenic treatment. | BACKGROUND: Lethal mutagenesis, or virus extinction promoted by mutagen-induced elevation of mutation rates of viruses, may meet with the problem of selection of mutagen-resistant variants, as extensively documented for standard, non-mutagenic antiviral inhibitors. Previously, we characterized a mutant of foot-and-mout... | ['Amino Acid Substitution', 'Antiviral Agents', 'Cells, Cultured', 'Drug Resistance, Viral', 'Foot-and-Mouth Disease Virus', 'Mutagenesis', 'Mutagens', 'Mutation', 'RNA, Viral', 'RNA-Dependent RNA Polymerase', 'Ribavirin', 'Species Specificity', 'Viral Proteins'] | 19,436,746 | [['E05.393.420.601.035', 'G05.558.109'], ['D27.505.954.122.388'], ['A11.251'], ['G06.225.420', 'G06.920.225', 'G07.690.773.984.269.420'], ['B04.820.578.750.070.250'], ['G05.558'], ['D27.888.569.468'], ['G05.365.590'], ['D13.444.735.828'], ['D08.811.913.696.445.735.780'], ['D13.570.800.790'], ['G16.824'], ['D12.776.964'... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Efficient translation of Dnmt1 requires cytoplasmic polyadenylation and Musashi binding elements. | Regulation of DNMT1 is critical for epigenetic control of many genes and for genome stability. Using phylogenetic analysis we characterized a block of 27 nucleotides in the 3'UTR of Dnmt1 mRNA identical between humans and Xenopus and investigated the role of the individual elements contained within it. This region cont... | ['Animals', 'Base Sequence', 'Blotting, Southern', 'Blotting, Western', 'Chickens', 'Cytoplasm', 'DNA (Cytosine-5-)-Methyltransferase 1', 'DNA (Cytosine-5-)-Methyltransferases', 'DNA Primers', 'Genetic Vectors', 'HeLa Cells', 'Humans', 'Immunoprecipitation', 'Mice', 'Molecular Sequence Data', 'Nerve Tissue Proteins', '... | 24,586,322 | [['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.196.401.114', 'E05.301.300.087', 'E05.601.150'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['A11.284.430.214'], ['D08.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Robustness, evolvability, and neutrality. | Biological systems, from macromolecules to whole organisms, are robust if they continue to function, survive, or reproduce when faced with mutations, environmental change, and internal noise. I focus here on biological systems that are robust to mutations and ask whether such systems are more or less evolvable, in the ... | ['Animals', 'Biological Evolution', 'Evolution, Molecular', 'Humans', 'Models, Genetic', 'Mutation', 'Phenotype', 'Selection, Genetic'] | 15,763,550 | [['B01.050'], ['G05.045', 'G16.075'], ['G05.045.250', 'G16.075.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.395.397'], ['G05.365.590'], ['G05.695'], ['G05.783']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Fasciocutaneous flaps]. | Fasciocutaneous flaps proved useful for covering soft tissue defects in the region of the leg. After experience with the use of these flaps in six patients the authors recommend this method for covering these defects. In all patients very satisfactory results were achieved. | ['Humans', 'Leg', 'Surgical Flaps'] | 8,310,343 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['A01.378.610.500'], ['A10.850.710', 'E07.862.710']] | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Conversion of levulinic acid into alkyl levulinates: Using lipase immobilized on meso-molding three-dimensional macroporous organosilica as catalyst. | For conversion of biomass-derived levulinic acid into alkyl levulinates, a novel kind of lipase-based biocatalyst was prepared through immobilized lipase B from C. antarctica (CALB) on organosilica material with highly ordered 3D macroporous organosilica frameworks and a 2D hexagonal meso-structure (named 3DOM/m-OS) fo... | ['1-Butanol', 'Catalysis', 'Enzymes, Immobilized', 'Esterification', 'Fungal Proteins', 'Levulinic Acids', 'Lipase'] | 28,982,086 | [['D02.033.415.110.175', 'D10.289.110.175'], ['G02.130'], ['D08.811.180', 'D12.776.463.500'], ['G02.111.270', 'G02.607.250', 'G03.344'], ['D12.776.354'], ['D02.241.755.547'], ['D08.811.277.352.100.400']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Analysis of genetic variation in the GenomEUtwin project. | Multiallelic short tandem repeat polymorphisms, or microsatellites, are useful markers in genome wide scans to identify chromosomal regions containing genes underlying disease loci. The biallelic single nucleotide polymorphism (SNP) can be used to fine map previously identified large candidate regions or to test functi... | ['Databases, Genetic', 'European Union', 'Genetic Variation', 'Genotype', 'Humans', 'International Cooperation', 'Microsatellite Repeats', 'Polymorphism, Single Nucleotide', 'Twin Studies as Topic'] | 14,624,723 | [['L01.313.500.750.300.188.400.325', 'L01.470.750.750.325'], ['I01.615.500.475'], ['G05.365'], ['G05.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I01.615.500'], ['G02.111.570.080.708.800.500', 'G05.360.080.708.800.500', 'G05.360.340.024.850.500'], ['G05.365.795.598'], ['E05.318.372.900', 'N05.715.360.330.9... | ['Information Science [L]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 |
CONTINUOUS VASCULAR RING (COV1) is a trans-Golgi network-localized membrane protein required for Golgi morphology and vacuolar protein sorting. | The trans-Golgi network (TGN) is a tubular-vesicular organelle that matures from the trans cisternae of the Golgi apparatus. In plants, the TGN functions as a central hub for three trafficking pathways: the secretory pathway, the vacuolar trafficking pathway and the endocytic pathway. Here, we describe a novel TGN-loca... | ['Arabidopsis Proteins', 'Cell Differentiation', 'Concanavalin A', 'Genetic Complementation Test', 'Green Fluorescent Proteins', 'Luminescent Proteins', 'Membrane Proteins', 'Phenotype', 'Plant Leaves', 'Plant Vascular Bundle', 'Protein Transport', 'Seed Storage Proteins', 'Vacuoles', 'trans-Golgi Network'] | 24,363,287 | [['D12.776.765.149'], ['G04.152'], ['D12.776.503.499.500', 'D12.776.765.678.500'], ['E05.393.281.526'], ['D12.776.532.265'], ['D12.776.532'], ['D12.776.543'], ['G05.695'], ['A18.024.812'], ['A18.450'], ['G03.143.700'], ['D12.776.765.725'], ['A11.284.430.214.190.875.190.920'], ['A11.284.430.214.190.875.336.850']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Pigment-dispersing hormone-immunoreactive neurons in the nervous system of wild-type Drosophila melanogaster and of several mutants with altered circadian rhythmicity. | Antisera against the crustacean pigment-dispersing hormone (beta-PDH) were used in immunocytochemical preparations to investigate the anatomy of PDH-immunoreactive neurons in the nervous system of wild-type Drosophila melanogaster and in that of several brain mutants of this species, some of which express altered circa... | ['Animals', 'Antibody Specificity', 'Circadian Rhythm', 'Drosophila melanogaster', 'Ganglia, Invertebrate', 'Immunohistochemistry', 'Invertebrate Hormones', 'Motor Activity', 'Mutation', 'Nerve Fibers', 'Nervous System', 'Peptides'] | 8,276,996 | [['B01.050'], ['G12.100'], ['G07.180.562.190'], ['B01.050.500.131.617.720.500.500.750.310.250.500'], ['A08.340.352', 'A13.408'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512', 'H01.158.201.344.512', 'H01.158.201.486.512', 'H... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Using the analytic hierarchy process (AHP) to develop and disseminate guidelines. | To be effective, practice guidelines must accommodate the unique circumstances of individual patients. This article describes how the analytic hierarchy process (AHP), a decision-making technique, could be used to create flexible guidelines by linking guideline developers and clinical decision makers as coworkers in a ... | ['Barium Sulfate', 'Clinical Medicine', 'Colonoscopy', 'Colorectal Neoplasms', 'Decision Support Techniques', 'Enema', 'Humans', 'Information Services', 'Physician-Patient Relations', 'Practice Guidelines as Topic', 'Sensitivity and Specificity'] | 1,287,526 | [['D01.103.075', 'D01.875.800.800.850.075'], ['H02.403.200'], ['E01.370.372.250.250.200', 'E01.370.388.250.250.250.160', 'E04.210.240.250.160', 'E04.502.250.250.250.160'], ['C04.588.274.476.411.307', 'C06.301.371.411.307', 'C06.405.249.411.307', 'C06.405.469.158.356', 'C06.405.469.491.307', 'C06.405.469.860.180'], ['E0... | ['Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Information Science [L]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Progesterone enhances in vitro development of bovine embryos. | Increased pregnancy rates in cattle given progesterone (P4) prior to 5 d after breeding have recently been reported. The objective was to determine if this increase in pregnancy rate could be attributed to a direct positive effect of P4 on the developing embryo. In Experiment 1, 280 bovine oocytes were inseminated in v... | ['Animals', 'Cattle', 'Embryo Culture Techniques', 'Embryo, Mammalian', 'Embryonic Development', 'Female', 'Fertilization in Vitro', 'Pregnancy', 'Pregnancy Rate', 'Progesterone'] | 21,872,313 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['E05.481.500.468'], ['A16.254'], ['G07.345.500.325.180', 'G08.686.784.170.104'], ['E02.875.800.750', 'E05.820.800.750'], ['G08.686.784.769'], ['E05.318.308.985.775', 'G08.686.705', 'N01.224.935.849', 'N06.850.505.400.975.775', 'N06.850.520.308.985.775'], ['D04.210... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Intakes of selected nutrients and food groups and risk of ovarian cancer. | In a hospital-based case-control study, we examined dietary intakes of selected nutrients and food groups and ovarian cancer risk among 496 women with primary, histologically confirmed epithelial ovarian cancer and 1,425 women with nonneoplastic diagnoses, ages 20-87 years, admitted to Roswell Park Cancer Institute bet... | ['Adult', 'Aged', 'Aged, 80 and over', 'Case-Control Studies', 'Diet', 'Dietary Fiber', 'Female', 'Fruit', 'Humans', 'Middle Aged', 'Odds Ratio', 'Ovarian Neoplasms', 'Regression Analysis', 'Risk Factors', 'Surveys and Questionnaires', 'Vegetables'] | 11,588,898 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['G07.203.650.240'], ['D09.301.416', 'G07.203.300.400', 'J02.500.400'], ['A18.024.500', 'G07.203.300.562', 'J02.500.562'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
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