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Involvement of glutamate receptors, protein kinases, and protein synthesis in memory for visual discrimination in the young chick. | Two-day-old chicks were trained to discriminate between edible chick crumbs and arrays of colored beads glued to the floor of their cage. Normal chicks learned this task within a few minutes and retained it for at least 24 h. The role of several biochemical systems known to be required for other forms of early learning... | ['Animals', 'Anisomycin', 'Behavior, Animal', 'Chickens', 'Discrimination, Psychological', 'Female', 'Male', 'Memory', 'Protein Biosynthesis', 'Protein Kinases', 'Receptors, Glutamate', 'Visual Perception'] | 8,616,587 | [['B01.050'], ['D03.383.773.050'], ['F01.145.113'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['F02.463.593.257'], ['F02.463.425.540'], ['G02.111.660.871', 'G03.734.871', 'G05.297.670'], ['D08.811.913.696.620.682'], ['D12.776.543.750.720.200.450'], ['F02.463.593.932']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Oxidative phosphorylation dysfunction does not increase the rate of accumulation of age-related mtDNA deletions in skeletal muscle. | Several reports described an age-related accumulation of a particular mitochondrial DNA (mtDNA) deletion ('common deletion') in post-mitotic tissues. These findings led to the hypothesis that free radicals generated inside the mitochondria could damage mtDNA during a normal life span. The impaired electron transfer fun... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Aging', 'Child', 'Child, Preschool', 'DNA, Mitochondrial', 'Epilepsies, Myoclonic', 'Female', 'Gene Deletion', 'Humans', 'MELAS Syndrome', 'Male', 'Middle Aged', 'Muscle, Skeletal', 'Oxidative Phosphorylation', 'Point Mutation', 'Polymerase Chain Reaction'] | 9,330,617 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['G07.345.124'], ['M01.060.406'], ['M01.060.406.448'], ['D13.444.308.283.225'], ['C10.228.140.490.375.130', 'C10.228.140.490.493.063'], ['G05.365.590.762.320', 'G05.558.800.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C05.651.... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Ultrasonic integrated backscatter coefficient profiling of human coronary arteries in vitro. | A theoretical formulation for the profile of the integrated backscatter coefficient (IBC) is derived. This new formulation is based on a theoretical treatment by Chen et al. [1]. It includes correction for the diffraction of the ultrasonic beam and correction for the non-ideal nature of the reference signal. The inclus... | ['Adult', 'Aged', 'Coronary Artery Disease', 'Coronary Vessels', 'Female', 'Humans', 'Image Processing, Computer-Assisted', 'Male', 'Mathematical Computing', 'Middle Aged', 'Models, Cardiovascular', 'Phantoms, Imaging', 'Scattering, Radiation', 'Tunica Intima', 'Ultrasonography'] | 11,367,784 | [['M01.060.116'], ['M01.060.116.100'], ['C14.280.647.250.260', 'C14.907.137.126.339', 'C14.907.585.250.260'], ['A07.015.114.269', 'A07.015.908.194'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['L01.224.680'], ['M01.060.116.630'], ['E05.599.395.161'], ['E07.671'], ['E05.196.822', 'G01.867'], ['A0... | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
CSM-lig: a web server for assessing and comparing protein-small molecule affinities. | Determining the affinity of a ligand for a given protein is a crucial component of drug development and understanding their biological effects. Predicting binding affinities is a challenging and difficult task, and despite being regarded as poorly predictive, scoring functions play an important role in the analysis of ... | ['Databases, Protein', 'Datasets as Topic', 'Internet', 'Ligands', 'Molecular Docking Simulation', 'Mutation', 'Protein Binding', 'Proteins', 'Reproducibility of Results', 'Small Molecule Libraries', 'Software', 'Substrate Specificity', 'User-Computer Interface'] | 27,151,202 | [['L01.313.500.750.300.188.400.300.750', 'L01.313.500.750.300.188.400.325.710', 'L01.470.750.750.300.750', 'L01.470.750.750.325.710'], ['E05.318.308.056', 'L01.313.500.750.300.188.400.500', 'L01.399.250.224', 'L01.470.750.750.431', 'N05.715.360.300.224', 'N06.850.520.308.056'], ['L01.224.230.110.500'], ['D27.720.470.48... | ['Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Moniezia infection in the dwarf breeds of small ruminants in Southern Nigeria. | A survey of Moniezia infection was conducted among two groups of sheep and goats, of dwarf breeds, in Nigeria: (i) those being reared under a traditional, extensive husbandry system in groups of rural villages situated in two different ecological zones; and (ii) those reared under an intensive system on experimental st... | ['Age Factors', 'Animals', 'Cestoda', 'Eating', 'Feces', 'Goats', 'Monieziasis', 'Nigeria', 'Parasite Egg Count', 'Seasons', 'Sheep', 'Sheep Diseases'] | 6,880,006 | [['N05.715.350.075', 'N06.850.490.250'], ['B01.050'], ['B01.050.500.500.736.215'], ['G07.203.650.283', 'G10.261.330'], ['A12.459'], ['B01.050.150.900.649.313.500.380.513'], ['C01.610.335.190.628', 'C01.610.335.349.656', 'C01.610.701.377.656', 'C22.674.377.656'], ['Z01.058.290.190.565'], ['E01.370.225.932.600', 'E05.200... | ['Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
The rapid detection of clonal T-cell proliferations in patients with lymphoid disorders. | A series of T-cell proliferations in peripheral blood, bone marrow, or tissue samples were analyzed for clonality. The technique used employs the polymerase chain reaction to amplify portions of the rearranged T-cell receptor beta chain genes, using primers recognizing conserved sequences of the variable, diversity, an... | ['B-Lymphocytes', 'Cell Division', 'Clone Cells', 'Gene Rearrangement, T-Lymphocyte', 'Humans', 'Leukemia', 'Lymphoma, Non-Hodgkin', 'Polymerase Chain Reaction', 'Sensitivity and Specificity', 'T-Lymphocytes'] | 2,012,172 | [['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.251.353'], ['G05.344.801', 'G12.500.287'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.337'], ['C04.557... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Stereoselectivity of each of the three steps of the heme oxygenase reaction: hemin to meso-hydroxyhemin, meso-hydroxyhemin to verdoheme, and verdoheme to biliverdin. | Heme oxygenase catalyzes the regiospecific oxidation of hemin to biliverdin IXalpha with concomitant liberation of CO and iron by three sequential monooxygenase reactions. The alpha-regioselectivity of heme oxygenase has been thought to result from the regioselective oxygenation of the heme alpha-meso position at the f... | ['Animals', 'Biliverdine', 'Carbon Monoxide', 'Ferrous Compounds', 'Heme', 'Heme Oxygenase (Decyclizing)', 'Hemin', 'Hydroxylation', 'Oxidation-Reduction', 'Rats', 'Spectrophotometry', 'Stereoisomerism'] | 12,809,497 | [['B01.050'], ['D03.383.129.578.840.249.184.200', 'D03.633.400.909.249.184.200', 'D04.345.783.249.184.200', 'D23.767.193.184.200'], ['D01.200.250', 'D01.362.200', 'D01.650.550.250'], ['D01.490.200'], ['D03.383.129.578.840.500.640.587', 'D03.633.400.909.500.640.587', 'D04.345.783.500.640.587', 'D23.767.727.640.587'], ['... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Psychometric properties of the Dutch version of the Orofacial Esthetic Scale (OES-NL) in dental patients with and without self-reported tooth wear. | The aim of this study was to test the psychometric properties of the Dutch version of the Orofacial Esthetic Scale (OES) in dental patients with and without self-reported tooth wear. The English version of the OES was translated into Dutch, following established guidelines for cross-cultural adaptation of health-relate... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Case-Control Studies', 'Female', 'Humans', 'Male', 'Middle Aged', 'Netherlands', 'Psychometrics', 'Reproducibility of Results', 'Self Concept', 'Self Report', 'Surveys and Questionnaires', 'Tooth Wear', 'Young Adult'] | 26,037,598 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['Z01.542.651'], ['F04.711.780'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685'... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Hepatitis B virus (HBV) genotyping in Belgian patients with chronic HBV infection. | Several studies have demonstrated that pathogenic and therapeutic differences exist among hepatitis B virus (HBV) genotypes. Therefore, this study established the prevalence of different HBV genotypes in 128 Belgian patients with chronic HBV infection. The prevalences of genotypes A and D, and mixed genotypes A and D, ... | ['Adult', 'Belgium', 'Blood Donors', 'DNA, Viral', 'Female', 'Genotype', 'Hepatitis B virus', 'Hepatitis B, Chronic', 'Humans', 'Male', 'Middle Aged', 'Prevalence'] | 15,882,202 | [['M01.060.116'], ['Z01.542.115'], ['M01.898.313'], ['D13.444.308.568'], ['G05.380'], ['B04.280.375.650.425', 'B04.450.390.650.425'], ['C01.221.250.500.100', 'C01.925.256.430.400.100', 'C01.925.440.435.100', 'C06.552.380.350.100', 'C06.552.380.705.437.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.11... | ['Named Groups [M]', 'Geographicals [Z]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Non-hybridization saturable mechanisms play a role in the uptake of (68)Ga-Labeled LNA-DNA mixmer antisense oligonucleotides in rats. | Oligonucleotides (ODN) are key molecules for the aim of preventing translation of a gene product or monitoring gene expression in tissues. However, multiple methodological and biological hurdles need to be solved before in vivo application in humans will be possible. For positron emission tomography (PET) investigation... | ['Animals', 'Cell Line, Tumor', 'Chromogranin A', 'Gallium Radioisotopes', 'Humans', 'Male', 'Oligonucleotides', 'Oligonucleotides, Antisense', 'Poly A', 'Poly I', 'RNA, Messenger', 'Rats', 'Rats, Sprague-Dawley', 'Receptors, Scavenger'] | 19,732,020 | [['B01.050'], ['A11.251.210.190', 'A11.251.860.180'], ['D12.776.631.199.249'], ['D01.268.556.289.500.400', 'D01.496.360.400', 'D01.496.749.360', 'D01.552.544.289.500.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D13.695.578.424'], ['D13.150.480', 'D13.444.600.150.640', 'D13.695.578.424.480', 'D27.720.470.53... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
In-vivo evaluation of the response of Galleria mellonella larvae to novel copper(II) phenanthroline-phenazine complexes. | Herein we report the in-vivo characterisation and metabolic changes in Galleria mellonella larvae to a series of bis-chelate copper(II) phenanthroline-phenazine cationic complexes of [Cu(phen)2]2+ (Cu-Phen), [Cu(DPQ)(Phen)]2+ (Cu-DPQ-Phen) and [Cu(DPPZ)(Phen)]2+ (Cu-DPPZ-Phen) (where phen = 1,10-phenanthroline, DPQ = d... | ['Animals', 'Copper', 'Drug Evaluation', 'Insecticides', 'Larva', 'Moths', 'Organometallic Compounds', 'Phenanthrolines', 'Phenazines'] | 29,906,780 | [['B01.050'], ['D01.268.556.195', 'D01.268.956.170', 'D01.552.544.195'], ['E05.290.625', 'E05.337.425'], ['D27.720.031.700.491', 'D27.888.723.491'], ['B05.500.500', 'G07.345.500.550.500.500'], ['B01.050.500.131.617.720.500.500.937.650'], ['D02.691'], ['D03.633.300.669'], ['D03.633.300.704']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effect of phenobarbital, spironolactone and pregnenolone-16 alpha-carbonitrile on bile formation in the rat. | The effects of pretreatment for 4 days with the hepatic microsomal enzyme inducers phenobarbital (8 mg/100 g body weight), spironolactone (20 mg/100 g body weight) and pregnenolone-16alpha-carbonitrile (7 mg/100 g body weight) on bile flow and bile pipid secretion have been compared in rats. Similar to phenobarbital, ... | ['Animals', 'Bile', 'Bile Acids and Salts', 'Body Weight', 'Cholesterol', 'Liver', 'Male', 'Organ Size', 'Phenobarbital', 'Phospholipids', 'Pregnenolone Carbonitrile', 'Rats', 'Spironolactone', 'Taurocholic Acid'] | 1,118,040 | [['B01.050'], ['A12.200.087'], ['D04.210.500.105'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['A03.620'], ['E01.370.600.115.100.660', 'E05.041.124.715', 'G07.100.100.660... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Methane plasma as a protective coating on intraocular lenses: an in vitro study. | A new methane plasma polymer was used to treat eight polymethylmetacrylate intraocular lenses (IOL). Another group of four lenses which had no treatment was used as control. The groups was compared in terms of the amount of endothelial cell damage caused after each of the twelve IOLs touched the central endothelium of ... | ['Animals', 'Endothelium, Corneal', 'In Vitro Techniques', 'Lenses, Intraocular', 'Methane', 'Methylmethacrylates', 'Microscopy, Electron, Scanning', 'Polymers', 'Rabbits'] | 2,625,384 | [['B01.050'], ['A09.371.060.067.318', 'A09.371.060.217.318', 'A10.272.491.318'], ['E05.481'], ['E07.632.500.460', 'E07.695.460'], ['D02.455.326.146.571'], ['D02.241.081.069.800.550', 'D05.750.716.822.111.650.605', 'D25.720.716.822.111.650.605', 'J01.637.051.720.716.822.111.650.605'], ['E01.370.350.515.402.541', 'E05.59... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
The Anterior Temporal Face Area Contains Invariant Representations of Face Identity That Can Persist Despite the Loss of Right FFA and OFA. | Macaque neurophysiology found image-invariant representations of face identity in a face-selective patch in anterior temporal cortex. A face-selective area in human anterior temporal lobe (fATL) has been reported, but has not been reliably identified, and its function and relationship with posterior face areas is poorl... | ['Adolescent', 'Brain Mapping', 'Facial Recognition', 'Female', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Neuropsychological Tests', 'Occipital Lobe', 'Prosopagnosia', 'Temporal Lobe', 'Young Adult'] | 25,527,821 | [['M01.060.057'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['F02.463.593.524.250.500', 'F02.463.593.524.500.500', 'F02.463.593.932.622.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['F04.711.513'], ['A08.186.211.200.885.287.500.571'], ['C10.597.606.76... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Acquisition of operant-trained bipedal locomotion in juvenile Japanese monkeys (Macaca fuscata): a longitudinal study. | This study investigated developmental aspects of the acquisition of operant-trained bipedal (Bp) standing and Bp walking in the normally quadrupedal (Qp) juvenile Japanese monkey (M. fuscata). Four male monkeys (age: 1.6 to 2.4 years, body weight: 3.3 to 4.6 kg) were initially operantly trained to stand upright on a sm... | ['Age Factors', 'Animals', 'Conditioning, Operant', 'Foot', 'Learning', 'Locomotion', 'Longitudinal Studies', 'Macaca', 'Male', 'Postural Balance'] | 14,999,136 | [['N05.715.350.075', 'N06.850.490.250'], ['B01.050'], ['F02.463.425.179.509'], ['A01.378.610.250'], ['F02.463.425', 'F02.784.629.529'], ['G07.568.500', 'G11.427.410.568'], ['E05.318.372.500.750.500', 'N05.715.360.330.500.750.500', 'N06.850.520.450.500.750.500'], ['B01.050.150.900.649.313.988.400.112.199.120.510'], ['F0... | ['Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Severe bradyarrhythmia in a patient with Alzheimer's disease and a patient with cerebral ischaemia, both induced by acute distension of the bladder. | Two case reports are presented of bradycardia in two elderly patients, which was resistant to atropine but which resolved immediately the acute bladder distension was treated. Generally, a sympathetic cardiac response is expected, and this paradoxical response may be due not only to lesions of the reflex loop involving... | ['Acute Disease', 'Aged', 'Aged, 80 and over', 'Alzheimer Disease', 'Atropine', 'Bradycardia', 'Brain Ischemia', 'Electrocardiography', 'Female', 'Humans', 'Tomography, X-Ray Computed', 'Urinary Bladder Diseases', 'Urinary Catheterization', 'Urinary Retention'] | 11,452,681 | [['C23.550.291.125'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['D02.145.074.722.229.199', 'D03.132.760.180.572.199', 'D03.132.889.180.648.199', 'D03.605.084.500.722.229.199', 'D03.605.869.229.199'], ['C14.280.067.319', 'C23.550.073.300'], ['C10.228.14... | ['Diseases [C]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Hypertension during pregnancy in South Australia, part 1: pregnancy outcomes. | BACKGROUND: There have been conflicting reports about pregnancy outcome in the hypertensive disorders of pregnancy. The present study was undertaken to examine outcomes using a population database.AIMS: To examine for differences in a range of pregnancy outcomes between three different groups of hypertensive women and ... | ['Birth Weight', 'Female', 'Gestational Age', 'Humans', 'Hypertension, Pregnancy-Induced', 'Incidence', 'Infant, Newborn', 'Length of Stay', 'Pregnancy', 'Pregnancy Complications, Cardiovascular', 'Pregnancy Outcome', 'Risk Factors', 'South Australia'] | 15,387,860 | [['C23.888.144.186', 'E01.370.600.115.100.160.120.186', 'E05.041.124.160.750.149', 'G07.100.100.160.120.186', 'G07.345.249.314.120.186'], ['G07.345.500.325.235.968', 'G08.686.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C13.703.395', 'C14.907.489.480'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]', 'Named Groups [M]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Medical relevance of protein-truncating variants across 337,205 individuals in the UK Biobank study. | Protein-truncating variants can have profound effects on gene function and are critical for clinical genome interpretation and generating therapeutic hypotheses, but their relevance to medical phenotypes has not been systematically assessed. Here, we characterize the effect of 18,228 protein-truncating variants across ... | ['Databases, Nucleic Acid', 'Genome-Wide Association Study', 'Humans', 'Phenotype', 'Proteins', 'Sequence Deletion', 'United Kingdom'] | 29,691,392 | [['L01.313.500.750.300.188.400.300.500', 'L01.313.500.750.300.188.400.325.630', 'L01.470.750.750.300.500', 'L01.470.750.750.325.630'], ['E05.318.370.392', 'E05.318.416.249', 'E05.393.385.500', 'E05.393.522.500', 'E05.393.760.640.500', 'N06.850.520.445.392', 'N06.850.520.470.500'], ['B01.050.150.900.649.313.988.400.112.... | ['Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Geographicals [Z]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 |
Two-Level Circumferential Lumbar Fusion Comparing Midline and Paraspinal Posterior Approach: 5-Year Interim Outcomes of a Randomized, Blinded, Prospective Study. | STUDY DESIGN: A prospective randomized and blinded comparative study of 2 patient groups with >5-year follow-up.OBJECTIVE: To compare the clinical outcomes and postoperative posterior muscle changes in patients with advanced degenerative disk disease undergoing 2-level circumferential spinal fusion using a posterior mi... | ['Adult', 'Female', 'Follow-Up Studies', 'Humans', 'Low Back Pain', 'Lumbar Vertebrae', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Pain Measurement', 'Paraspinal Muscles', 'Prospective Studies', 'Spinal Fusion', 'Treatment Outcome'] | 24,136,056 | [['M01.060.116'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.888.592.612.107.400'], ['A02.835.232.834.519'], ['E01.370.350.825.500'], ['M01.060.116.630'], ['E01.370.600.550.324'], ['A02.633.567.175.750'], ['E05.318.37... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Transcriptional analysis of the IL-33 receptor suppression of tumourigenicity 2 and its effects on canine Type 2 T helper cells: a preliminary study. | BACKGROUND: Interleukin (IL)-33 has been implicated in the pathogenesis of canine atopic dermatitis, a Type 2 T helper cell (Th2)-associated disease. In humans, IL-33 mediates its biological effects through the receptor suppression of tumourigenicity 2 (ST2), which is preferentially expressed on Th2 cells. The effects ... | ['Animals', 'Carcinogenesis', 'Cytokines', 'Dermatitis, Atopic', 'Dog Diseases', 'Dogs', 'Interleukin-13', 'Interleukin-33', 'Interleukin-5', 'Receptors, Cytokine', 'Th2 Cells', 'Transcription, Genetic'] | 29,178,475 | [['B01.050'], ['C04.697.098', 'C23.550.727.098'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['C16.320.850.210', 'C17.800.174.193', 'C17.800.815.193', 'C17.800.827.210', 'C20.543.480.343'], ['C22.268'], ['B01.050.150.900.649.313.750.250.216.200'], ['D12.644.276.374.465.513', 'D12.776.467.374.465.513', 'D23.... | ['Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A new approach to the limiting dilution assay. | Improved methods of human immunodeficiency virus isolation have sparked an increased interest in determination of the number and proportion of infected cells in plasma samples. The limiting dilution assay is a popular method of determining the proportion of infected cells. We propose a new estimator of the proportion o... | ['Acquired Immunodeficiency Syndrome', 'Colony Count, Microbial', 'HIV', 'Humans', 'Markov Chains', 'Reproducibility of Results'] | 8,019,579 | [['C01.221.250.875.040', 'C01.221.812.640.400.040', 'C01.778.640.400.040', 'C01.925.782.815.616.400.040', 'C01.925.813.400.040', 'C01.925.839.040', 'C20.673.480.040'], ['E01.370.225.875.220', 'E05.200.875.220'], ['B04.820.650.589.650.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.600.500', 'E05.3... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Intake of grapefruit juice alters the metabolic pattern of cyclosporin A in renal transplant recipients. | OBJECTIVE: The aim of the present study was to investigate the effect of grapefruit juice on the pharmacokinetics of cyclosporin A (CsA), as Sandimmun Neoral, and its main metabolites, M1, M9 and M4N, in renal transplant recipients.METHODS: Ten renal transplant recipients, on CsA-based immunosuppressive therapy, were i... | ['Adolescent', 'Adult', 'Aged', 'Area Under Curve', 'Beverages', 'Citrus paradisi', 'Cross-Over Studies', 'Cyclosporine', 'Female', 'Food-Drug Interactions', 'Humans', 'Immunosuppressive Agents', 'Kidney Transplantation', 'Male', 'Middle Aged', 'Time Factors', 'Water'] | 12,395,977 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['E05.318.740.200', 'G03.787.101', 'G07.690.725.064', 'N06.850.520.830.200'], ['G07.203.100', 'J02.200'], ['B01.650.940.800.575.912.250.875.177.538'], ['E05.318.370.150', 'N05.715.360.325.150', 'N06.850.520.445.150'], ['D04.345.566.235.300', 'D12.644.641.235.300']... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Production of IL-10 by melanoma cells: examination of its role in immunosuppression mediated by melanoma. | Previous studies have shown that IL-10 may modulate immune responses towards the humoral arm by inhibiting production of cytokines involved in cell-mediated responses. In the present studies, we found that mRNA to IL-10 could be demonstrated in 66% of melanoma cell lines by PCR amplification of reverse-transcribed mRNA... | ['Base Sequence', 'Blotting, Southern', 'Enzyme-Linked Immunosorbent Assay', 'Humans', 'Interleukin-10', 'Interleukin-2', 'Lymphocyte Culture Test, Mixed', 'Melanoma', 'Molecular Sequence Data', 'Molecular Weight', 'Polymerase Chain Reaction', 'Precipitin Tests', 'RNA, Messenger', 'Skin Neoplasms', 'Tumor Cells, Cultur... | 8,314,354 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.196.401.114', 'E05.301.300.087', 'E05.601.150'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.465.510', 'D12.776.46... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
The postmortem incidence of senile ecchymoses. | Although senile ecchymoses are a well-recognized phenomenon on hospital wards, in patients who die in other settings they may be wrongly interpreted as bruising caused by physical assault. Therefore, we studied a total of 410 elderly (> 50 years of age) patients by a prospective examination of autopsy reports to elucid... | ['Aged', 'Aged, 80 and over', 'Aging', 'Ecchymosis', 'Female', 'Humans', 'Incidence', 'Male', 'Middle Aged', 'Postmortem Changes'] | 7,825,549 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['G07.345.124'], ['C15.378.100.452', 'C23.550.414.625', 'C23.888.885.312'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.985.525.375'], ['M01.060.116.630'], ['C23.550.260... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The cytology, histology and prevalence of cell types in canine lymphoma classified according to the National Cancer Institute Working Formulation. | No significance has been shown yet between the cytological subtypes of canine lymphoma and clinical behaviour. This paper describes and illustrates the cytological and histological criteria for application of the National Cancer Institute Working Formulation classification system, a scheme with demonstrated prognostic ... | ['Animals', 'Burkitt Lymphoma', 'Dog Diseases', 'Dogs', 'Humans', 'Lymphoma', 'Lymphoma, Non-Hodgkin', 'Mitosis', 'National Institutes of Health (U.S.)', 'Prognosis', 'United States'] | 3,756,669 | [['B01.050'], ['C01.925.256.466.313.165', 'C01.925.928.313.165', 'C04.557.386.480.150.165', 'C15.604.515.569.480.150.165', 'C20.683.515.761.480.150.165'], ['C22.268'], ['B01.050.150.900.649.313.750.250.216.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.386', 'C15.604.515.569', 'C20.683.515.761'], ['C... | ['Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
[The non-neurogenic neurogenic bladder (Hinman's syndrome) in children: What are pronostic criteria based on a 31 cases multicentric study]. | PURPOSE: To identify in children the pejorative estimated criteria of a extreme dysfunctional voiding can leading to a Hinman syndrome.PATIENTS AND METHODS: Retrospective and multicentric study of 31 patients (19 boys and 12 girls), resulting from three universitary medical center (Besancon, Lyon, Nantes), which were d... | ['Adolescent', 'Child', 'Child, Preschool', 'Female', 'Humans', 'Infant', 'Male', 'Prognosis', 'Retrospective Studies', 'Urinary Bladder, Neurogenic'] | 20,380,992 | [['M01.060.057'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['E01.789'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.520.450.500.500.500', 'N06.850.520.450.500.750.825'], ['C10... | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Estradiol stimulates in vitro the secretion of insulin-like growth factors by the clonal osteoblastic cell line, UMR106. | UMR106 cells, a rat osteosarcoma derived clonal line, secreted insulin-like growth factors (IGF) in vitro. The IGF-II levels corrected for the cell numbers were 7-8 times higher than the IGF-I levels in the medium. Both growth factors were higher by 4-5 fold in medium conditioned by rapidly growing cells than in medium... | ['Animals', 'Calcitriol', 'Estradiol', 'In Vitro Techniques', 'Osteoblasts', 'Osteosarcoma', 'Rats', 'Somatomedins', 'Time Factors', 'Tumor Cells, Cultured'] | 2,916,989 | [['B01.050'], ['D04.210.500.247.222.159.478.387.300', 'D04.210.500.247.808.146.478.387.300', 'D04.210.500.812.768.196.478.387.300', 'D10.570.938.146.478.387.300'], ['D04.210.500.365.415.248', 'D06.472.334.851.437.500'], ['E05.481'], ['A11.329.629'], ['C04.557.450.565.575.650', 'C04.557.450.795.620'], ['B01.050.150.900.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A balanced translocation t(4;9) (q35;q12) with a breakpoint within the heterochromatic region of chromosome 9 in a woman with recurrent abortion. | A case of recurrent abortion was found to be associated with the presence in the mother of a balanced translocation between chromosomes 4 and 9. The karyotypes of the proposita was: 46,XX,t(4;9)(q35;q12). The effects of this translocation are discussed in the light of other cases reported in the literature. | ['Abortion, Habitual', 'Adult', 'Chromosomes, Human, 4-5', 'Chromosomes, Human, 6-12 and X', 'Female', 'Heterochromatin', 'Humans', 'Pedigree', 'Pregnancy', 'Translocation, Genetic', 'Trisomy'] | 7,438,505 | [['C13.703.039.089'], ['M01.060.116'], ['A11.284.187.520.300.280', 'G05.360.162.520.300.280'], ['A11.284.187.520.300.325', 'G05.360.162.520.300.325'], ['A11.284.430.106.279.345.190.160.180.383', 'D12.776.664.224.466', 'G05.360.160.180.383'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.393.673'], ['G08.686.78... | ['Diseases [C]', 'Named Groups [M]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Antiendothelial antibodies in sera of patients with infective endocarditis. | Infective endocarditis is characterized by the colonization of endocardium by microorganisms. Except for Staphylococcus aureus, microorganisms are not able to adhere to and grow on endocardial cells; prior damage, e.g., by shear stress or other mechanical factors, is necessary. But other causes may well have a share. T... | ['Antibodies', 'Cells, Cultured', 'Cytoplasm', 'Endocarditis', 'Endothelium, Vascular', 'Enzyme-Linked Immunosorbent Assay', 'Fluorescent Antibody Technique, Indirect', 'Humans', 'Infections', 'Reference Values'] | 11,215,535 | [['D12.776.124.486.485.114', 'D12.776.124.790.651.114', 'D12.776.377.715.548.114'], ['A11.251'], ['A11.284.430.214'], ['C14.280.282'], ['A07.015.700.500', 'A10.272.491.355'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['E01.370.225.500.607.512.24... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Sensory gating event-related potentials and oscillations in schizophrenia patients and their unaffected relatives. | BACKGROUND: The P50 event-related potential sensory gating deficit, a failure to inhibit responses to repeated stimuli, is a leading endophenotype for schizophrenia (SZ). Both gamma and beta event-related oscillations (EROs) are major contributors to the auditory P50 response. However, the topographic distribution of g... | ['Adult', 'Aged', 'Electroencephalography', 'Evoked Potentials', 'Family', 'Female', 'Humans', 'Male', 'Middle Aged', 'Reaction Time', 'Schizophrenia', 'Sensory Gating'] | 20,363,872 | [['M01.060.116'], ['M01.060.116.100'], ['E01.370.376.300', 'E01.370.405.245'], ['G07.265.216.500', 'G11.561.200.500'], ['F01.829.263', 'I01.880.853.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.796.817', 'F02.830.650', 'F04.669.817', 'G11.561.677'], ['F03.700.750'], ['G11.561.794']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Comparison of the prognostic value of tumour- and patient-related factors in patients undergoing potentially curative surgery for colon cancer. | AIM: To comprehensively compare the prognostic value of tumour- and patient-related factors in patients undergoing curative surgery for colon cancer.METHOD: From a database of 287 patients who underwent elective resection between 1997 and 2005, tumour factors including stage and host factors including systemic inflamma... | ['Age Factors', 'Aged', 'Alkaline Phosphatase', 'Biomarkers', 'Blood Cell Count', 'Cause of Death', 'Chi-Square Distribution', 'Colonic Neoplasms', 'Female', 'Follow-Up Studies', 'Hemoglobins', 'Humans', 'Male', 'Neoplasm Invasiveness', 'Neoplasm Staging', 'Prognosis', 'Risk Factors'] | 19,555,389 | [['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['D08.811.277.352.650.035'], ['D23.101'], ['E01.370.225.500.195.107', 'E01.370.225.625.107', 'E05.200.500.195.107', 'E05.200.625.107', 'E05.242.195.107', 'G04.140.107', 'G09.188.105'], ['E05.318.308.985.550.250', 'N01.224.935.698.100', 'N06.850.505.400.975.5... | ['Health Care [N]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Multiple neural origins of early auditory evoked potential of rat. | The multiple-origin hypothesis has been often considered for an unclear neurogenesis of a characteristic wave in various evoked potentials, none of which has been verified so far. Auditory evoked potential (AEP) in the temporal cortex of rodents has typical slow positive/negative (P1/N1) biphasic waves, which are occas... | ['Acoustic Stimulation', 'Animals', 'Brain Mapping', 'Electroencephalography', 'Evoked Potentials, Auditory', 'Principal Component Analysis', 'Rats', 'Rats, Wistar', 'Reaction Time', 'Temporal Lobe'] | 17,825,493 | [['E02.037', 'E02.190.888.030', 'E05.723.136'], ['B01.050'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['E01.370.376.300', 'E01.370.405.245'], ['G07.265.216.500.370', 'G07.888.250', 'G11.561.200.500.370'], ['E05.318.740.562'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.9... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Physician adherence to blood pressure guidelines and its effect on seniors. | STUDY OBJECTIVE: To compare physician adherence to guidelines from the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure for patients younger than 65 years of age with those aged 65 years and older, and to analyze whether factor groupings (subsets ... | ['Adult', 'Aged', 'Aged, 80 and over', 'Female', 'Guideline Adherence', 'Humans', 'Hypertension', 'Male', 'Middle Aged', 'Practice Guidelines as Topic', 'Retrospective Studies'] | 18,576,899 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['N04.761.337', 'N05.715.360.395'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['M01.060.116.630'], ['N04.761.700.350.650', 'N05.700.350.650'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N0... | ['Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Regioselective enzymatic acylation of ribavirin to give potential multifunctional derivatives. | Lipase-catalyzed synthesis of potential multifunctional ribavirin derivatives was performed in acetone. Divinyl dicarboxylates with different chain lengths (C4, C6, C9, C10) were used as acyl donors and the reactions were catalyzed by lipase immobilized on acrylic resin from Candida antarctica (CAL-B). Ribavirin was re... | ['Acetone', 'Acylation', 'Alkenes', 'Butadienes', 'Candida', 'Chromatography, Thin Layer', 'Dicarboxylic Acids', 'Enzymes, Immobilized', 'Lipase', 'Ribavirin', 'Substrate Specificity'] | 16,049,740 | [['D02.522.064'], ['G02.111.012', 'G02.607.063', 'G03.040'], ['D02.455.326.271'], ['D02.455.326.271.665.146.240'], ['B01.300.107.795.095', 'B01.300.381.147', 'B01.300.930.176'], ['E05.196.181.400.537'], ['D02.241.081.337'], ['D08.811.180', 'D12.776.463.500'], ['D08.811.277.352.100.400'], ['D13.570.800.790'], ['G02.111.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
5-HTTLPR, anxiety and gender interaction moderates right amygdala volume in healthy subjects. | Genetic variants within the serotonin transporter gene (5-HTTLPR) impact the neurobiology and risk for anxiety-related behaviours. There are also gender differences in the prevalence of anxiety-related behaviours. Although numerous studies have investigated the influence of 5-HTTLPR genotype on the neural systems invol... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Amygdala', 'Analysis of Variance', 'Anxiety', 'Chi-Square Distribution', 'Female', 'Functional Laterality', 'Genotype', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Psychiatric Status Rating Scales', 'Serotonin Plasma Membrane Transport Proteins',... | 23,986,266 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['A08.186.211.180.090', 'A08.186.211.200.885.287.249.152'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['F01.470.132'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], [... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
High Prevalence and Temporal Variation of Extended Spectrum â-Lactamase-Producing Bacteria in Urban Swedish Mallards. | Antibiotic resistant bacteria present a growing global healthcare challenge. Previous research demonstrates that wild birds harbor extended spectrum â-lactamase (ESBL)-producing Enterobacteriaceae and may contribute to their dissemination. We aimed to assess prevalence and temporal variation in the detection rate of ES... | ['Anti-Bacterial Agents', 'Escherichia coli', 'Escherichia coli Infections', 'Genetic Variation', 'Humans', 'Klebsiella Infections', 'Klebsiella pneumoniae', 'Microbial Sensitivity Tests', 'Prevalence', 'Sweden', 'beta-Lactamases'] | 29,304,312 | [['D27.505.954.122.085'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['C01.150.252.400.310.330'], ['G05.365'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C01.150.252.400.310.503'], ['B03.440.450.425.425.600', 'B03.660.250.150.400.590'], ['E01.370.225.875.595', 'E05.200.875.595', 'E05.337.550.400'],... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Lymphoid cell dependence of eosinophil response to antigen. VI. The effect of selective removal of T or B lymphocytes on the capacity of primed spleen cells to adoptively transferred immunity to tetanus toxoid. | Spleens from mice primed with tetanus toxoid 30 days earlier contain memory cells capable of adoptively transferring secondary type cell-mediated (eosinophil) and humoral (antitoxin) responses to irradiated, reconstituted recipients. Spleen cells derived from 10-day-primed donors, on the other hand, possess the capacit... | ['Animals', 'Antibody Formation', 'Antibody-Producing Cells', 'Antilymphocyte Serum', 'B-Lymphocytes', 'Eosinophils', 'Female', 'Immunity, Cellular', 'Immunity, Maternally-Acquired', 'Immunoglobulin G', 'Immunologic Memory', 'Mice', 'Rabbits', 'Radiation Chimera', 'Radiation Effects', 'Spleen', 'T-Lymphocytes', 'Tetanu... | 1,079,015 | [['B01.050'], ['G12.450.050.370.250'], ['A11.063', 'A15.382.032'], ['A12.207.152.846.500.203', 'D12.776.124.486.485.114.573.203', 'D12.776.124.790.651.114.573.203', 'D12.776.377.715.548.114.573.203', 'D20.215.401.203'], ['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.38... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
The Fo subunits of the Escherichia coli F1Fo-ATP synthase are sufficient to form a functional proton pore. | The assembly of the Fo sector of the Escherichia coli ATP synthase has been studied using both structural and functional criteria for assembly. Cross-linking E. coli minicell membranes containing only the Fo subunits a, b, and c with dithiobis(succinimidyl propionate) (DSP) produces b2 and c2 dimers that are generated ... | ['Carbonyl Cyanide m-Chlorophenyl Hydrazone', 'Cell Membrane', 'Cross-Linking Reagents', 'DNA Restriction Enzymes', 'Escherichia coli', 'Kinetics', 'Macromolecular Substances', 'Plasmids', 'Proton-Translocating ATPases', 'Species Specificity', 'Succinimides'] | 2,863,271 | [['D02.442.288.200', 'D02.626.260'], ['A11.284.149'], ['D27.720.470.410.210'], ['D08.811.150.280', 'D08.811.277.352.335.350.300', 'D08.811.277.352.355.325.300'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['G01.374.661', 'G02.111.490'], ['D05'], ['G05.360.600'], ['D08.811.277.040.025.325', 'D08.811.913.696... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A lack of correlation between mast cells, angiogenesis, and outcome in non-small cell lung cancer. | Although a direct association between mast cells and cancer tumors is generally accepted, the exact nature of this relationship appears contradictory. The aim of this study was to clarify the effect of mast cells on tumor angiogenesis and outcome in Non-small cell lung cancer (NSCLC) patients. The tissue specimens eval... | ['Carcinoma, Non-Small-Cell Lung', 'Cell Count', 'Endothelial Cells', 'Female', 'Follow-Up Studies', 'Humans', 'Lung Neoplasms', 'Male', 'Mast Cells', 'Microvessels', 'Middle Aged', 'Neovascularization, Pathologic', 'Prognosis'] | 22,646,306 | [['C04.588.894.797.520.109.220.249', 'C08.381.540.140.500', 'C08.785.520.100.220.500'], ['E01.370.225.500.195', 'E05.200.500.195', 'E05.242.195', 'G04.140'], ['A11.436.275'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Molecular pathogenesis of equine coital exanthema (ECE): temperature sensitivity (TS) and restriction endonuclease (RE) fragment profiles of several field isolates. | Examination of six field isolates of equine herpesvirus 3, the causative agent of equine coital exanthema, indicates that all were temperature sensitive (ts) at the body temperature, 39 degrees C, of their host (Equine asinus and callabus) when grown in cell culture. The isolates were characterized by fingerprint analy... | ['Animals', 'Cells, Cultured', 'Cytopathogenic Effect, Viral', 'DNA Restriction Enzymes', 'DNA, Viral', 'Genes, Viral', 'Herpesviridae', 'Herpesvirus 3, Equid', 'Horses', 'Nucleotide Mapping', 'Temperature'] | 3,028,334 | [['B01.050'], ['A11.251'], ['E01.370.225.500.384.235', 'E05.200.500.384.235', 'E05.242.384.235', 'G06.920.190'], ['D08.811.150.280', 'D08.811.277.352.335.350.300', 'D08.811.277.352.355.325.300'], ['D13.444.308.568'], ['G05.360.340.024.340.364.875', 'G05.360.340.358.024.875', 'G05.360.340.358.840.500'], ['B04.280.382'],... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Curcumin prevents oxidative renal damage induced by acetaminophen in rats. | Acetaminophen (APAP) can cause life-threatening renal damages and there is no specific treatment for APAP-induced renal damage. The aim of this study was to investigate the protective effects of curcumin (CMN) on APAP-induced nephrotoxicity. Nephrotoxicity was induced in male Wistar Albino rats by the administration of... | ['Acetaminophen', 'Analgesics, Non-Narcotic', 'Animals', 'Anti-Inflammatory Agents, Non-Steroidal', 'Catalase', 'Curcumin', 'Glutathione', 'Glutathione Peroxidase', 'Kidney Diseases', 'Male', 'Oxidative Stress', 'Protective Agents', 'Rats', 'Rats, Wistar', 'Superoxide Dismutase'] | 19,345,714 | [['D02.065.199.092.040', 'D02.092.146.113.092.040'], ['D27.505.696.663.850.014.040', 'D27.505.954.427.040.100'], ['B01.050'], ['D27.505.696.663.850.014.040.500', 'D27.505.954.158.030', 'D27.505.954.329.030'], ['D08.811.682.732.332'], ['D02.455.326.146.485.222.222', 'D02.455.426.559.389.657.166.200', 'D02.455.426.559.69... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Movement as an index of vitality: comparing wild type and the age-1 mutant of Caenorhabditis elegans. | We have asked whether the mutant form of the age-1 gene, which lengthens the life span of the nematode Caenorhabditis elegans up to 70%, also affects the ability to move during this extended period of life. Both age-1 mutants and wild-type controls display a linear loss of movement as the nematodes age. age-1 mutant st... | ['Aging', 'Animals', 'Behavior, Animal', 'Caenorhabditis elegans', 'Habituation, Psychophysiologic', 'Longevity', 'Movement', 'Mutation', 'Reproducibility of Results'] | 7,671,016 | [['G07.345.124'], ['B01.050'], ['F01.145.113'], ['B01.050.500.500.294.400.875.660.250.250'], ['F02.463.425.393', 'F02.830.422', 'G11.561.312'], ['G07.345.124.519', 'G07.540'], ['G07.568', 'G11.427.410'], ['G05.365.590'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Genotyping of single-nucleotide polymorphisms by primer extension reaction in a dry-reagent dipstick format. | The primer extension (PEXT) reaction is the most widely used approach to genotyping of single-nucleotide polymorphisms (SNPs). Current methods for analysis of PEXT reaction products are based on electrophoresis, fluorescence resonance energy transfer, fluorescence polarization, pyrosequencing, mass spectrometry, microa... | ['DNA Primers', 'Genotype', 'Humans', 'Mannose-Binding Lectin', 'Nucleic Acid Hybridization', 'Polymerase Chain Reaction', 'Polymorphism, Single Nucleotide', 'Sensitivity and Specificity', 'Sequence Analysis, DNA'] | 17,222,001 | [['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['G05.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.503.280.249.500', 'D12.776.503.311.500'], ['E05.393.661', 'G02.111.611'], ['E05.393.620.500'], ['G05.365.795.598'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700'... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Rapid diagnosis of Mycobacterium tuberculosis by multiplex polymerase chain reaction from clinical specimens. | An essential element in the control of tuberculosis is the rapid, sensitive and specific identification of the causative agent. Until now, screening and diagnosis are largely based on clinical signs, radiological examination, tuberculin tests, sputum examination under the microscope, or culture for mycobacteria. Tuberc... | ['DNA, Bacterial', 'Humans', 'Mycobacterium tuberculosis', 'Polymerase Chain Reaction', 'RNA, Ribosomal, 16S', 'Sensitivity and Specificity', 'Time Factors', 'Tuberculosis'] | 12,561,502 | [['D13.444.308.212'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B03.510.024.962.500.702', 'B03.510.460.400.410.552.552.702'], ['E05.393.620.500'], ['D13.444.735.686.670'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700', 'N05.715.360.750.725', 'N06.850.520.445.800', 'N06.850.520.830.872... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Non-invasive sensitive brain tumor detection using dual-modality bioimaging nanoprobe. | Despite decades of efforts, non-invasive sensitive detection of small malignant brain tumors still remains challenging. Here we report a dual-modality 124I-labeled gold nanostar (124I-GNS) probe for sensitive brain tumor imaging with positron emission tomography (PET) and subcellular tracking with two-photon photolumin... | ['Animals', 'Brain Neoplasms', 'Diagnostic Imaging', 'Fluorodeoxyglucose F18', 'Gold', 'HEK293 Cells', 'Humans', 'Iodine Radioisotopes', 'Metal Nanoparticles', 'Mice', 'Optical Imaging', 'Organ Specificity', 'Positron Emission Tomography Computed Tomography'] | 30,856,613 | [['B01.050'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['E01.370.350'], ['D09.254.229.500'], ['D01.268.556.322', 'D01.268.956.186', 'D01.552.544.322'], ['A11.251.210.172.750', 'A11.436.334'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.268.380.400.500.496', 'D01.496.448.496', 'D01.496.7... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
The lipid lowering drug lovastatin protects against doxorubicin-induced hepatotoxicity. | Liver is the main detoxifying organ and therefore the target of high concentrations of genotoxic compounds, such as environmental carcinogens and anticancer drugs. Here, we investigated the usefulness of lovastatin, which is nowadays widely used for lipid lowering purpose, as a hepatoprotective drug following the admin... | ['Animals', 'Antibiotics, Antineoplastic', 'Chemical and Drug Induced Liver Injury', 'Connective Tissue Growth Factor', 'DNA Damage', 'Dose-Response Relationship, Drug', 'Doxorubicin', 'Epirubicin', 'Gene Expression Regulation', 'Hydroxymethylglutaryl-CoA Reductase Inhibitors', 'Inflammation', 'Liver Cirrhosis', 'Lovas... | 22,712,078 | [['B01.050'], ['D27.505.954.248.106'], ['C06.552.100', 'C25.100.562', 'C25.723.260'], ['D12.644.276.200.100', 'D12.776.467.200.100', 'D12.776.860.300.200.100', 'D23.529.237.100'], ['G05.200'], ['G07.690.773.875', 'G07.690.936.500'], ['D02.455.426.559.847.562.050.200.175', 'D04.615.562.050.200.175', 'D09.408.051.059.200... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Photochemical degradation of marbofloxacin and enrofloxacin in natural waters. | The photochemical fate of Marbofloxacin (MAR) and Enrofloxacin (ENR), two Fluoroquinolones (FQs) largely used as veterinary bactericides known to be present in surface waters, was investigated in aqueous solution. The degradation of these pollutants (5-50 microg L(-1) starting concentration) was complete in about 1 h b... | ['Enrofloxacin', 'Fluoroquinolones', 'Hydrogen-Ion Concentration', 'Organic Chemicals', 'Photochemistry', 'Photolysis', 'Rivers', 'Salts', 'Sunlight', 'Water'] | 20,481,547 | [['D03.633.100.810.835.322.304'], ['D03.633.100.810.835.322'], ['G02.300'], ['D02'], ['H01.181.529.711'], ['G02.740.685'], ['G01.311.750', 'G16.500.275.280.650', 'N06.230.232.650'], ['D01.786'], ['G01.358.500.505.650.836', 'G01.750.250.650.836', 'G01.750.770.578.836', 'G16.500.275.063.725.525', 'G16.500.750.775.525', '... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Proximal hypospadias and risk of acquired cryptorchidism. | PURPOSE: We hypothesized that boys with proximal hypospadias are at increased risk for acquired cryptorchidism.MATERIALS AND METHODS: We retrospectively studied the records of 114 boys who underwent repair for proximal hypospadias and had at least 1 year of followup, and 342 age matched boys receiving well child examin... | ['Adolescent', 'Child', 'Child, Preschool', 'Cohort Studies', 'Cryptorchidism', 'Humans', 'Hypospadias', 'Infant', 'Male', 'Retrospective Studies', 'Risk Factors'] | 20,639,045 | [['M01.060.057'], ['M01.060.406'], ['M01.060.406.448'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['C12.294.829.258', 'C12.706.258', 'C16.131.939.258', 'C19.391.829.258'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.294.494.400', 'C12.706.516', 'C13.351.875.466', 'C16.131... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The influence of hip muscle strength on gait in individuals with a unilateral transfemoral amputation. | INTRODUCTION: A unilateral transfemoral amputation (TFA) has a major impact on function. A leg-length discrepancy is the primary structural change, accompanied by the loss of lower-limb muscle volume and function. Prostheses can help individuals with a TFA to regain function, but such individuals still do not reach the... | ['Adult', 'Amputation', 'Female', 'Femur', 'Gait', 'Hip', 'Humans', 'Male', 'Middle Aged', 'Muscle Strength', 'Young Adult'] | 32,877,428 | [['M01.060.116'], ['E04.555.080'], ['A02.835.232.043.150'], ['E01.370.600.250', 'G11.427.410.568.900.750'], ['A01.378.610.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.370.600.425', 'G11.427.560'], ['M01.060.116.815']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Regulation of melatonin synthesis in the ovine pineal gland. | The results presented here show clearly that the rapid nocturnal increase in circulating melatonin in sheep is associated with an equally rapid increase in melatonin production in the pineal gland. Pineal NAT activity and NAS concentration also increased under this condition, indicating that NAT activity is an importan... | ['Acetylation', 'Acetylserotonin O-Methyltransferase', 'Animals', 'Arylamine N-Acetyltransferase', 'Circadian Rhythm', 'Cycloheximide', 'Gene Expression Regulation', 'Isoproterenol', 'Light', 'Melatonin', 'Pineal Gland', 'Prazosin', 'Receptors, Adrenergic', 'Reproduction', 'Serotonin', 'Sheep', 'Tryptophan'] | 1,772,063 | [['G02.111.012.052', 'G02.607.063.052', 'G03.040.052'], ['D08.811.913.555.500.100'], ['B01.050'], ['D08.811.913.050.134.138'], ['G07.180.562.190'], ['D03.383.621.808.240'], ['G05.308'], ['D02.033.100.291.439', 'D02.092.063.291.439', 'D02.092.311.649', 'D02.455.426.559.389.657.166.175.649'], ['G01.358.500.505.650', 'G01... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effect of biogenic polyamine spermine on the structure and function of photosystem I. | We located the binding sites of spermine (Spm) to PSI sub-membrane proteins and the impact of this interaction on the photoprotection of PSI activity, using spectroscopic methods and molecular modeling. Our results showed that at high Spm content the polyamine binds PSI polypeptides through H-bonding and induces major ... | ['Binding Sites', 'Hydrogen Bonding', 'Hydrophobic and Hydrophilic Interactions', 'Light', 'Molecular Docking Simulation', 'Oxidation-Reduction', 'Photosystem I Protein Complex', 'Protein Binding', 'Protein Structure, Quaternary', 'Protein Structure, Secondary', 'Spectroscopy, Fourier Transform Infrared', 'Spermine', '... | 25,318,020 | [['G02.111.570.120'], ['G02.282'], ['G02.409'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['E05.599.595.249', 'L01.224.160.249'], ['G02.700', 'G03.295.531'], ['D05.500.562.488.500', 'D08.811.600.710.500', 'D12.776.157.530.450.250.875.492', 'D12.776.543.585.450.250.875.492', 'D12.776.... | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
[Maternal and obstetrical data in a retrospective cohort of 170 newborns from polydrug using mothers, in the Paris area, 1999-2008]. | OBJECTIVES: Polydrug use in pregnancy is harmful. This survey aimed to explore the issue of the associations of substances during pregnancy and to determine the consumer profiles.PATIENTS AND METHODS: One hundred and seventy newborns whose mothers were psychoactive substances users were identified over the period 1999 ... | ['Abortion, Induced', 'Cocaine-Related Disorders', 'Cohort Studies', 'Ethanol', 'Female', 'Heroin Dependence', 'Humans', 'Infant, Newborn', 'Marijuana Smoking', 'N-Methyl-3,4-methylenedioxyamphetamine', 'Pregnancy', 'Pregnancy Complications', 'Pregnancy Outcome', 'Psychotropic Drugs', 'Retrospective Studies', 'Smoking'... | 20,708,857 | [['E04.520.050'], ['C25.775.300', 'F03.900.300'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['D02.033.375'], ['C25.775.643.500.400', 'F03.900.647.500.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['F01.145.610.875', 'F01.145.805.250.500'], ['D02.092.47... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Named Groups [M]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Safety of Live Liver Donation by Individuals With G6PD Deficiency: Initial Results and Comparative Study. | BACKGROUND: G6PD deficiency (G6PDd) is the commonest genetic enzyme defect in the world. However, baring a single case report, there is no published literature regarding the safety of donor hepatectomy in G6PDd individuals.METHODS: Potential donors with World Health Organization class III or class IV G6PDd without evid... | ['Adolescent', 'Adult', 'Biomarkers', 'Blood Transfusion', 'Case-Control Studies', 'Donor Selection', 'Female', 'Glucosephosphate Dehydrogenase Deficiency', 'Hemoglobins', 'Hemolysis', 'Hepatectomy', 'Humans', 'Liver Transplantation', 'Male', 'Postoperative Complications', 'Risk Factors', 'Time Factors', 'Tissue Donors... | 26,760,569 | [['M01.060.057'], ['M01.060.116'], ['D23.101'], ['E02.095.135'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['E04.936.537.500', 'N02.421.911.600'], ['C15.378.071.141.150.480', 'C16.320.070.480', 'C16.320.565.202.402', 'C18.452.648.202.402'], ['D12.776.124.400', 'D12.776.422.316.762']... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Effects of dietary fucoxanthin on cholesterol metabolism in diabetic/obese KK-A(y) mice. | BACKGROUND: Fucoxanthin is a xanthophyll present in brown seaweeds and has several beneficial effects, including anti-obesity and anti-diabetic effects. However, we and another group previously observed that fucoxanthin increases serum cholesterol levels in rodents. Cholesterol is an important component of cell membran... | ['Adipose Tissue, White', 'Administration, Oral', 'Animals', 'Anti-Obesity Agents', 'Cholesterol', 'Epididymis', 'Gene Expression', 'Hydroxymethylglutaryl CoA Reductases', 'Liver', 'Male', 'Mice', 'Mice, Obese', 'Muscle, Skeletal', 'Obesity', 'Organ Size', 'Proprotein Convertase 9', 'Proprotein Convertases', 'Serine En... | 22,962,999 | [['A10.165.114.830'], ['E02.319.267.100'], ['B01.050'], ['D27.505.954.203'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['A05.360.444.371'], ['G05.297'], ['D08.811.682.047.820.150.415'], ['A03.620'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.150.900.649.313.992.635.505.500.5... | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleotide sequence of a cDNA clone for human aldolase B. | Two specific clones for human aldolase B were isolated from a human liver cDNA library using a rat aldolase B cDNA probe. The clones were identified by positive hybridization-selection and one of them was sequenced. The 127 C-terminal residues of the human protein were deduced from this nucleotide sequence analysis. Th... | ['Amino Acid Sequence', 'Animals', 'Base Sequence', 'Cloning, Molecular', 'DNA', 'Fructose-Bisphosphate Aldolase', 'Humans', 'Isoenzymes', 'Liver', 'Nucleic Acid Hybridization', 'Rats'] | 6,689,266 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.393.220'], ['D13.444.308'], ['D08.811.520.224.062.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.348', 'D12.776.800.300'], ['A03.620'], ['E05.393.661', 'G02.111.611'], ['B01.050.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Community analysis of the abundance and diversity of biting midge species (Diptera: Ceratopogonidae) in three European countries at different latitudes. | BACKGROUND: The outbreaks of bluetongue and Schmallenberg disease in Europe have increased efforts to understand the ecology of Culicoides biting midges and their role in pathogen transmission. However, most studies have focused on a specific habitat, region, or country. To facilitate wider comparisons, and to obtain a... | ['Animals', 'Biodiversity', 'Ceratopogonidae', 'Ecosystem', 'Entomology', 'Female', 'Insect Vectors', 'Italy', 'Microscopy', 'Netherlands', 'Sweden'] | 29,587,832 | [['B01.050'], ['G16.500.275.157.049', 'N06.230.124.049'], ['B01.050.500.131.617.720.500.500.750.712.500.500'], ['G16.500.275.157', 'N06.230.124'], ['H01.158.273.943.409'], ['N06.850.335.188.100.500', 'N06.850.520.203.375.100.500'], ['Z01.542.489'], ['E01.370.350.515', 'E05.595', 'H01.671.617.562'], ['Z01.542.651'], ['Z... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
The effect of autologous conditioned plasma on the treatment of focal chondral defects of the knee. An experimental study. | The purpose of the present study was to evaluate the effect of local application of Autologous Conditioned Plasma (ACP) on the treatment of full-thickness cartilage injuries of the knee. The hypothesis of the study was that ACP can enhance healing response of injured cartilage. A full-thickness chondral lesion on the w... | ['Animals', 'Bone Regeneration', 'Cartilage, Articular', 'Chondrocytes', 'Data Interpretation, Statistical', 'Endpoint Determination', 'Hindlimb', 'Intercellular Signaling Peptides and Proteins', 'Joints', 'Platelet-Rich Plasma', 'Prostheses and Implants', 'Sheep', 'Treatment Outcome'] | 21,669,149 | [['B01.050'], ['G11.427.213.140', 'G16.762.150.150'], ['A02.165.407.150', 'A02.835.583.192'], ['A11.329.171'], ['E05.245.380', 'E05.318.740.300', 'L01.313.500.750.190.380', 'N05.715.360.750.300', 'N06.850.520.830.300'], ['E05.315'], ['A13.473'], ['D12.644.276', 'D12.776.467', 'D23.529'], ['A02.835.583'], ['A12.207.152.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Electronic interpretation of conformational preferences in benzyl derivatives and related compounds. | Quantum Theory of Atoms in Molecules (QTAIM) analysis on B3LYP/6-311++G(2d,2p) 6d electron densities of five benzyl derivatives (C(6)H(5)-CH(2)X; X = F, Cl, OH, SH, NH(2)) and seven related fluorides of furan, pyrrole, and naphthalene indicates that the preference for perpendicular or gauche conformation exhibited by t... | ['Benzyl Compounds', 'Electrons', 'Molecular Conformation', 'Quantum Theory'] | 21,939,255 | [['D02.455.426.559.389.140'], ['G01.249.335', 'G01.358.500.750'], ['G02.111.570.820'], ['H01.671.579.800']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
MRI findings in a case of a superficial siderosis associated with an ependymoma. | We present the imaging findings of superficial siderosis of the central nervous system associated with an ependymoma of the posterior fossa in a patient who presented with progressive bilateral sensorineural hearing loss and cerebellar ataxia. The ependymoma was a homogeneous well-defined mass of the fourth ventricle w... | ['Adult', 'Ependymoma', 'Female', 'Humans', 'Infratentorial Neoplasms', 'Magnetic Resonance Imaging', 'Siderosis'] | 12,297,737 | [['M01.060.116'], ['C04.557.465.625.600.380.290', 'C04.557.470.670.380.290', 'C04.557.580.625.600.380.290'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.614.250.195.411', 'C10.228.140.211.500', 'C10.551.240.250.400'], ['E01.370.350.825.500'], ['C08.381.483.581.750', 'C08.381.520.702.750', 'C24.800.773']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Is magnetic resonance imaging of hepatic hemangioma any different in liver fibrosis and cirrhosis compared to normal liver? | PURPOSE: To compare qualitative and quantitative magnetic resonance (MR) imaging characteristics of hepatic hemangiomas in patients with normal, fibrotic and cirrhotic livers.MATERIALS AND METHODS: Retrospective, institutional review board approved study (waiver of informed consent). Eighty-nine consecutive patients wi... | ['Adult', 'Aged', 'Aged, 80 and over', 'Diagnosis, Differential', 'Female', 'Hemangioma', 'Humans', 'Liver Cirrhosis', 'Liver Neoplasms', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Retrospective Studies'] | 25,703,650 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E01.171'], ['C04.557.645.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C06.552.630', 'C23.550.355.412'], ['C04.588.274.623', 'C06.301.623', 'C06.552.697'], ['E01.370.350.825.500'], ['M01.060.116.630'], ['E05.318.372.500.500.500', 'E05.318.372... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Clinical significance of surveillance culture in liver transplant recipients. | BACKGROUND: Routine microbiologic surveillance is a method of infection control, but its clinical significance in transplant recipients is not known. We analyzed microbiologic data to evaluate the influence of cultured microorganisms between the point of surveillance and infectious episodes in liver transplant recipien... | ['Bacteria', 'Colony Count, Microbial', 'Humans', 'Liver Transplantation', 'Prospective Studies'] | 24,767,358 | [['B03'], ['E01.370.225.875.220', 'E05.200.875.220'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.095.147.725.490', 'E04.210.650', 'E04.936.450.490', 'E04.936.580.490'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Changing varicella epidemiology in active surveillance sites--United States, 1995-2005. | Significant reductions in varicella incidence were reported from 1995 to 2000 in the varicella active surveillance sites of Antelope Valley (AV), California, and West Philadelphia (WP), Pennsylvania. We examined incidence rates, median age, and vaccination status of case patients for 1995-2005. Coverage data were from ... | ['Adolescent', 'Adult', 'California', 'Chickenpox', 'Chickenpox Vaccine', 'Child', 'Child, Preschool', 'Humans', 'Immunization Programs', 'Incidence', 'Infant', 'Pennsylvania', 'Population Surveillance', 'United States'] | 18,419,413 | [['M01.060.057'], ['M01.060.116'], ['Z01.107.567.875.580.200', 'Z01.107.567.875.760.200'], ['C01.925.256.466.930.250'], ['D20.215.894.899.290.130'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N02.421.726.608'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505... | ['Named Groups [M]', 'Geographicals [Z]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Interviews of medical school entrants: to what purpose? | Students entering the Faculty of Medicine at The University of New South Wales are selected by one of two methods. Most of the students are selected solely on the basis of results of higher school certificate examinations, the remainder under a special category for mature-age entrants. After they have been accepted int... | ['Educational Measurement', 'Female', 'Humans', 'Interview, Psychological', 'Male', 'Probability', 'Retrospective Studies', 'School Admission Criteria', 'Students, Medical'] | 7,132,876 | [['I02.399'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F04.669.599'], ['E05.318.740.600', 'G17.680', 'N05.715.360.750.625', 'N06.850.520.830.600'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.520.450.500.500.500', 'N06.850.520.4... | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Named Groups [M]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
CD47 augments Fas/CD95-mediated apoptosis. | Fas (CD95) mediates apoptosis of many cell types, but the susceptibility of cells to killing by Fas ligand and anti-Fas antibodies is highly variable. Jurkat T cells lacking CD47 (integrin-associated protein) are relatively resistant to Fas-mediated death but are efficiently killed by Fas ligand or anti-Fas IgM (CH11) ... | ['Animals', 'Antigens, CD', 'Apoptosis', 'CD47 Antigen', 'Humans', 'Jurkat Cells', 'Mice', 'Mice, Inbred C57BL', 'fas Receptor'] | 15,917,238 | [['B01.050'], ['D23.050.301.264.035', 'D23.101.100.110'], ['G04.146.954.035'], ['D12.776.395.550.014', 'D12.776.543.550.147'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.251.210.190.495', 'A11.251.860.180.495', 'A15.382.490.555.567.569.440'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.52... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Molecular analysis of spontaneous glomerulosclerosis in Os/+ mice, a model with reduced nephron mass. | Oligosyndactyly mice (ROP Os/+) are a radiation-induced mutant strain with reduced glomerular number and increased glomerular size. We found that they develop glomerulosclerosis. At 3 mo, ROP Os/+ mice had diffuse mesangial expansion by light microscopy, whereas their +/+ littermates did not. Electron microscopic morph... | ['Actins', 'Animals', 'Cell Adhesion Molecules, Neuronal', 'Collagen', 'Collagenases', 'Extracellular Matrix Proteins', 'Female', 'Fluorescent Antibody Technique', 'Glomerulosclerosis, Focal Segmental', 'Kidney', 'Kidney Glomerulus', 'Mice', 'Mice, Mutant Strains', 'Microscopy, Fluorescence', 'Nephrons', 'Organ Size', ... | 7,544,540 | [['D05.750.078.730.250', 'D12.776.210.500.100', 'D12.776.220.525.255'], ['B01.050'], ['D12.776.395.550.200.250', 'D12.776.543.550.200.250', 'D23.050.301.350.250'], ['D05.750.078.280', 'D12.776.860.300.250'], ['D08.811.277.656.300.480.205', 'D08.811.277.656.675.374.205'], ['D12.776.860.300'], ['E01.370.225.500.607.512.2... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Renegotiating masculine identity after prostate cancer treatment. | Because little is known about how low-income Latino and African American men attribute meaning and adapt to prostate cancer treatment-related symptoms relative to masculine identity, in this study we sought to develop a descriptive model of this process. Using qualitative methods, 60 Latino and 35 African American/Blac... | ['African Americans', 'California', 'Erectile Dysfunction', 'Gender Identity', 'Hispanic Americans', 'Humans', 'Interviews as Topic', 'Male', "Men's Health", 'Prostatic Neoplasms', 'Psychology'] | 18,955,461 | [['M01.686.508.100.100', 'M01.686.754.100'], ['Z01.107.567.875.580.200', 'Z01.107.567.875.760.200'], ['C12.294.644.486', 'F03.835.400'], ['F01.393.446.250', 'F01.752.747.385.200', 'F01.752.747.722.200', 'F02.739.794.793.200'], ['M01.686.754.441'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.420', 'L0... | ['Named Groups [M]', 'Geographicals [Z]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
Inhibitory effect of substituted aromatic hydrocarbons on adherence of Escherichia coli to human epithelial cells. | Adherence of Escherichia coli to epithelial cells is postulated to be a necessary step in the pathogenesis of urinary tract infections. Investigations have focused on the role of carbohydrates in adherence because of the ability of mannose to inhibit adherence; however, there have been several reports of an additional ... | ['Adhesiveness', 'Animals', 'Binding Sites', 'Dose-Response Relationship, Drug', 'Epithelium', 'Escherichia coli', 'Female', 'Guinea Pigs', 'Hemagglutination', 'Humans', 'In Vitro Techniques', 'Mannose', 'Nitrophenols', 'Structure-Activity Relationship', 'Vagina'] | 3,519,463 | [['G02.860.139'], ['B01.050'], ['G02.111.570.120'], ['G07.690.773.875', 'G07.690.936.500'], ['A10.272'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['B01.050.150.900.649.313.992.550'], ['G02.111.026.500', 'G12.122.100.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.481'], ['D09.947.875.359.58... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The effects of cytochalasin D and phorbol myristate acetate on the apical endocytosis of ricin in polarised Caco-2 cells. | Apical endocytosis of 125I-ricin in Caco-2 cells was inhibited > 95% by hypertonic and/or acid media, consistent with the major uptake route being clathrin-mediated. The presence of apical cell surface bound ricin-gold in clathrin coated pits and vesicles was observed by electron microscopy. An electron microscopic inv... | ['Caco-2 Cells', 'Cell Polarity', 'Coated Pits, Cell-Membrane', 'Cytochalasin D', 'Down-Regulation', 'Endocytosis', 'Humans', 'Microscopy, Electron', 'Microvilli', 'Protein Kinase C', 'Ricin', 'Tetradecanoylphorbol Acetate'] | 9,013,340 | [['A11.251.210.190.160', 'A11.251.860.180.160', 'A11.436.140'], ['G04.250'], ['A11.284.149.165.175'], ['D03.633.100.473.231.450', 'D23.946.587.370.450'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['G04.417'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.515.402', 'E05.595.402'], ['A11.284.180... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Spiritual wellbeing and perceived uncertainty in patients with multiple sclerosis in south-east Iran. | BACKGROUND: The increasing incidence of multiple sclerosis (MS) over the previous decade in Iran has been examined in the literature. This chronic and unpredictable disease creates psychological impairment, including uncertainty, among patients. It is important to examine the extent of uncertainty experienced by patien... | ['Adolescent', 'Adult', 'Female', 'Humans', 'Iran', 'Male', 'Middle Aged', 'Multiple Sclerosis', 'Spirituality', 'Uncertainty', 'Young Adult'] | 25,350,214 | [['M01.060.057'], ['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.245.500.350'], ['M01.060.116.630'], ['C10.114.375.500', 'C10.314.350.500', 'C20.111.258.250.500'], ['F02.880.705', 'K01.844.664.500'], ['E05.318.740.600.900', 'F02.463.785.373.820', 'G17.680.875', 'N05.715.360.750.625.850', 'N... | ['Named Groups [M]', 'Organisms [B]', 'Geographicals [Z]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Humanities [K]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
[Effect and mechanism of aerial parts of Salvia miltiorrhiza effective constituents on glycolipid metabolism of high sugar-induced Drosophila melanogaster metabolic disorder model]. | To evaluate the effect and mechanism of aerial parts of Salvia miltiorrhiza(SM) on high sugar-induced Drosophila melanogaster metabolic disorder model. The levels of glucose, triglyceride and protein in SM were detected; nymphosis time was recorded, and the reliability of metabolic disorder model as well as the mechani... | ['Animals', 'Drosophila melanogaster', 'Glycolipids', 'Metabolic Diseases', 'Plant Components, Aerial', 'Plant Extracts', 'Reproducibility of Results', 'Salvia miltiorrhiza', 'Sugars'] | 29,728,041 | [['B01.050'], ['B01.050.500.131.617.720.500.500.750.310.250.500'], ['D09.400.410', 'D10.390'], ['C18.452'], ['A18.024'], ['D20.215.784.500', 'D26.667'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['B01.650.940.800.575.912.250.583.520.922.750'], ['D09.947']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Nicotine Promotes Cholangiocarcinoma Growth in Xenograft Mice. | Nicotine, the main addictive substance in tobacco, is known to play a role in the development and/or progression of a number of malignant tumors. However, nicotine's involvement in the pathogenesis of cholangiocarcinoma is controversial. Therefore, we studied the effects of nicotine on the growth of cholangiocarcinoma ... | ['Aged', 'Animals', 'Bile Duct Neoplasms', 'Cell Line, Tumor', 'Cell Proliferation', 'Cholangiocarcinoma', 'Extracellular Signal-Regulated MAP Kinases', 'Female', 'Fibrosis', 'Heterografts', 'Humans', 'Keratin-19', 'MAP Kinase Signaling System', 'Male', 'Mice', 'Middle Aged', 'Neoplasm Transplantation', 'Nicotine', 'Ni... | 28,315,314 | [['M01.060.116.100'], ['B01.050'], ['C04.588.274.120.250', 'C06.130.120.120', 'C06.130.320.120', 'C06.301.120.250'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.161.750', 'G07.345.249.410.750'], ['C04.557.470.200.025.450'], ['D08.811.913.696.620.682.700.567.249', 'D12.644.360.450.169', 'D12.776.476.450.169'], ['C23.5... | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Hormone stimulation and chemotherapy in advanced prostate cancer: interim analysis of an ongoing randomized trial. | We report here in the interim analysis of an ongoing randomized clinical trial designed to test whether androgen priming enhances tumor chemosensitivity in men with stage D prostate cancer refractory to orchiectomy. All patients are continuously treated with aminoglutethimide and hydrocortisone, to lower adrenal androg... | ['Aged', 'Aminoglutethimide', 'Androgens', 'Antineoplastic Combined Chemotherapy Protocols', 'Bone Neoplasms', 'Clinical Trials as Topic', 'Humans', 'Hydrocortisone', 'Male', 'Middle Aged', 'Prostatic Neoplasms', 'Random Allocation', 'Spinal Cord Compression', 'Time Factors'] | 3,518,596 | [['M01.060.116.100'], ['D03.383.621.808.425.100'], ['D27.505.696.399.472.161'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['C04.588.149', 'C05.116.231'], ['E05.318.372.250.250', 'N05.715.360.330.250.250', 'N06.850.520.450.250.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D04.210.500.745.745... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Merkel cell carcinoma and multiple basal cell carcinoma in an African albino woman with HIV infection. | A 25-year-old HIV-infected African albino woman developed an aggressive Merkel cell carcinoma on her face and at least 10 basal cell carcinomas, mainly on sun-exposed parts of her body. HIV infection, immune deficiency and sun exposure are known risk factors for the development of Merkel cell carcinoma. Chemotherapy an... | ['Adult', 'Albinism', 'Antineoplastic Agents', 'Antiretroviral Therapy, Highly Active', 'Carcinoma, Basal Cell', 'Carcinoma, Merkel Cell', 'Drug Therapy, Combination', 'Fatal Outcome', 'Female', 'HIV Infections', 'Humans', 'Skin Neoplasms'] | 15,544,700 | [['M01.060.116'], ['C11.270.040', 'C16.320.290.040', 'C16.320.565.100.102', 'C16.320.850.080', 'C17.800.621.440.102', 'C17.800.827.080', 'C18.452.648.100.102'], ['D27.505.954.248'], ['E02.319.310.075'], ['C04.557.470.200.165', 'C04.557.470.565.165'], ['C01.925.256.721.150', 'C01.925.928.216', 'C04.557.465.625.650.240.3... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Direct-fed glucose oxidase and its combination with B. amyloliquefaciens SC06 on growth performance, meat quality, intestinal barrier, antioxidative status, and immunity of yellow-feathered broilers. | This experiment investigated the effects of dietary glucose oxidase (GOD) and its combination with B. amyloliquefaciens SC06 (BaSC06) on the growth performance, meat quality, intestinal physical barrier, antioxidative status and immunity of male Lingnan yellow-feathered broilers. A total of 720 1-d-old broilers were as... | ['Animal Feed', 'Animal Nutritional Physiological Phenomena', 'Animals', 'Bacillus amyloliquefaciens', 'Chickens', 'Diet', 'Dietary Supplements', 'Glucose Oxidase', 'Male', 'Meat', 'Probiotics', 'Random Allocation'] | 30,085,304 | [['G07.203.300.300.100', 'J02.500.300.100'], ['G07.203.650.161'], ['B01.050'], ['B03.300.390.400.158.218.076', 'B03.353.500.100.218.076', 'B03.510.100.100.218.076', 'B03.510.415.400.158.218.076', 'B03.510.460.410.158.218.076'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['G07.203.650.240'], ['G07.2... | ['Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Chronic I(1)-imidazoline agonism : sympathetic mechanisms in hypertension. | Evidence exists for a state of sympathetic hyperactivity in essential hypertension, and moxonidine, a new central sympathetic inhibitor, has been introduced for its treatment. Acute administration of moxonidine lowers peripheral sympathetic neural output. This study examined the effect of chronic moxonidine therapy, at... | ['Aged', 'Antihypertensive Agents', 'Blood Pressure', 'Cold Temperature', 'Hand Strength', 'Heart Rate', 'Humans', 'Hypertension', 'Imidazoles', 'Isometric Contraction', 'Leg', 'Longitudinal Studies', 'Middle Aged', 'Reflex', 'Sympathetic Nervous System', 'Vascular Resistance', 'Vasoconstriction'] | 10,856,275 | [['M01.060.116.100'], ['D27.505.954.411.162'], ['E01.370.600.875.249', 'G09.330.380.076'], ['G01.906.595.272', 'G16.500.275.063.725.710.300', 'G16.500.750.775.710.300', 'N06.230.300.100.725.154', 'N06.230.300.100.725.710.300'], ['E01.370.600.425.500', 'G11.427.560.500'], ['E01.370.600.875.500', 'G09.330.380.500'], ['B0... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A novel accurate ACRS-PCR method with a digestion internal control for identification of wild type and YMDD mutants of hepatitis B virus strains. | As a consequence of the point mutation in the YMDD motif of the hepatitis B virus (HBV) polymerase gene, lamivudine-resistant mutants have been reported in chronic hepatitis B patients who underwent lamivudine therapy. The objective of the study was to develop a novel accurate artificially created restriction site (ACR... | ['Adult', 'Aged', 'Antiviral Agents', 'DNA Primers', 'DNA, Viral', 'Deoxyribonucleases, Type II Site-Specific', 'Drug Resistance, Viral', 'Female', 'Hepatitis B virus', 'Hepatitis B, Chronic', 'Humans', 'Lamivudine', 'Male', 'Middle Aged', 'Mutation', 'Polymerase Chain Reaction', 'Reference Standards', 'Reproducibility... | 16,962,669 | [['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.122.388'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['D13.444.308.568'], ['D08.811.150.280.260', 'D08.811.277.352.335.350.300.260', 'D08.811.277.352.355.325.300.260'], ['G06.225.420', 'G06.920.225', 'G07.690.773.984.269.420'], ['B04.280.375.650.425... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Blood pressure measurement in pregnant women in the left lateral recumbent position. | To evaluate blood pressure in pregnant women in the left lateral position, we studied indirect blood pressure in 169 patients with normal blood pressure, chronic hypertension, and preeclampsia in the supine and then the lateral recumbent positions. Two additional patients had aortic arch blood pressure compared with in... | ['Blood Pressure', 'Blood Pressure Determination', 'Female', 'Humans', 'Hypertension', 'Pre-Eclampsia', 'Pregnancy', 'Pregnancy Complications, Cardiovascular', 'Reference Values'] | 9,077,621 | [['E01.370.600.875.249', 'G09.330.380.076'], ['E01.370.370.140', 'E01.370.600.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['C13.703.395.249'], ['G08.686.784.769'], ['C13.703.634', 'C14.583'], ['E05.978.810']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bayesian models of cognition revisited: Setting optimality aside and letting data drive psychological theory. | Recent debates in the psychological literature have raised questions about the assumptions that underpin Bayesian models of cognition and what inferences they license about human cognition. In this paper we revisit this topic, arguing that there are 2 qualitatively different ways in which a Bayesian model could be cons... | ['Bayes Theorem', 'Cognition', 'Drive', 'Humans', 'Models, Psychological', 'Psychological Theory'] | 28,358,549 | [['E05.318.740.600.200', 'N05.715.360.750.625.150', 'N06.850.520.830.600.200'], ['F02.463.188'], ['F01.658.293'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.695'], ['F02.739']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Evaluation of Coomassie dye binding method for microprotein assay in diabetic proteinuria. | A simple and relatively cheap method for quantitating diabetic microproteinuria with Coomassie brilliant blue dye binding method was evaluated. It provides a proportional reactivity to urinary albumin as measured by the more expensive immunoassay. The significant correlation between haemoglobin A1 and microproteinuria ... | ['Adult', 'Aged', 'Albuminuria', 'Clinical Laboratory Techniques', 'Diabetes Mellitus, Type 1', 'Female', 'Humans', 'Male', 'Methods', 'Middle Aged', 'Rosaniline Dyes'] | 3,717,876 | [['M01.060.116'], ['M01.060.116.100'], ['C12.777.934.734.269', 'C13.351.968.934.734.269', 'C23.888.942.750.269'], ['E01.370.225', 'E05.200'], ['C18.452.394.750.124', 'C19.246.267', 'C20.111.327'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.581'], ['M01.060.116.630'], ['D02.092.146.755']] | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Influence of female cuticular hydrocarbon (CHC) profile on male courtship behavior in two hybridizing field crickets Gryllus firmus and Gryllus pennsylvanicus. | BACKGROUND: The hybridizing field crickets, Gryllus firmus and Gryllus pennsylvanicus have several barriers that prevent gene flow between species. The behavioral pre-zygotic mating barrier, where males court conspecifics more intensely than heterospecifics, is important because by acting earlier in the life cycle it h... | ['Animal Scales', 'Animals', 'Courtship', 'Female', 'Gryllidae', 'Hybridization, Genetic', 'Hydrocarbons', 'Male', 'Reproduction', 'Sexual Behavior, Animal'] | 32,019,492 | [['A13.079', 'A17.100'], ['B01.050'], ['F01.145.802.279'], ['B01.050.500.131.617.678.410'], ['E05.820.150.390', 'G05.090.390'], ['D02.455'], ['G08.686.784'], ['F01.145.113.252.748']] | ['Anatomy [A]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Three-dimensional analysis of mandibular functional units in adult patients with unilateral posterior crossbite: A cone beam study with the use of mirroring and surface-to-surface matching techniques | OBJECTIVES: To use three-dimensional (3D) mirroring and surface-to-surface techniques to determine any differences in mandibular functional unit shape and morphology between the crossbite side and non-crossbite side in adult patients with posterior unilateral crossbite who had not received any corrective treatment for ... | ['Adult', 'Cone-Beam Computed Tomography', 'Facial Asymmetry', 'Female', 'Humans', 'Male', 'Malocclusion', 'Mandible', 'Mandibular Condyle', 'Young Adult'] | 31,013,132 | [['M01.060.116'], ['E01.370.350.700.810.810.490', 'E01.370.350.825.810.810.399'], ['C23.300.505'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C07.793.494'], ['A02.835.232.781.324.502.632', 'A14.521.632'], ['A02.835.232.781.324.502.632.600', 'A14.521.632.600'], ['M01.060.116.815']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Size-related changes in foot impact mechanics in hoofed mammals. | Foot-ground impact is mechanically challenging for all animals, but how do large animals mitigate increased mass during foot impact? We hypothesized that impact force amplitude scales according to isometry in animals of increasing size through allometric scaling of related impact parameters. To test this, we measured l... | ['Animals', 'Biomechanical Phenomena', 'Body Size', 'Hoof and Claw', 'Mammals', 'Models, Theoretical', 'Organ Size'] | 23,382,967 | [['B01.050'], ['G01.154.090', 'G01.374.089'], ['E01.370.600.115.100.160', 'E05.041.124.160', 'G07.100.100.160', 'G07.345.249.314'], ['A13.491'], ['B01.050.150.900.649'], ['E05.599'], ['E01.370.600.115.100.660', 'E05.041.124.715', 'G07.100.100.660', 'G07.345.249.690']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Intracellular pH on protein kinase C and ionomycin potentiation of isoproterenol-stimulated cyclic AMP and cyclic GMP production in rat pinealocytes. | In rat pinealocytes, alpha 1-adrenergic activation, which leads to cytoplasmic alkalinization, also potentiates the beta-adrenergic stimulated cyclic AMP (cAMP) and cyclic GMP (cGMP) responses. Both elevation of intracellular calcium ([Ca2+]i) and activation of protein kinase C are involved in the potentiation mechanis... | ['Ammonium Chloride', 'Animals', 'Cells, Cultured', 'Cyclic AMP', 'Cyclic GMP', 'Hydrogen-Ion Concentration', 'Ionomycin', 'Isoproterenol', 'Male', 'Nifedipine', 'Phorbol Esters', 'Pineal Gland', 'Propionates', 'Protein Kinase C', 'Rats', 'Rats, Sprague-Dawley'] | 1,331,328 | [['D01.210.450.150.050', 'D01.625.062.249'], ['B01.050'], ['A11.251'], ['D03.633.100.759.646.138.395', 'D13.695.462.200', 'D13.695.667.138.395', 'D13.695.827.068.395'], ['D03.633.100.759.646.454.160', 'D13.695.462.275', 'D13.695.667.454.160', 'D13.695.827.426.160'], ['G02.300'], ['D10.251.355.391'], ['D02.033.100.291.4... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Interleukin-10 but not transforming growth factor-â1 gene expression is up-regulated by vitamin D treatment in multiple sclerosis patients. | Multiple sclerosis (MS) is an inflammatory and autoimmune disease. Variety of different genetics and environmental factors are involved in MS pathology. The epidemiological studies demonstrated that vitamin D has immune and immunomodulating effects on MS disease. Therefore, this study aims to evaluate the effect of vit... | ['Adult', 'Female', 'Humans', 'Injections, Intramuscular', 'Interleukin-10', 'Male', 'Multiple Sclerosis', 'Transforming Growth Factor beta1', 'Treatment Outcome', 'Up-Regulation', 'Vitamin D', 'Young Adult'] | 25,680,585 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.267.530.460'], ['D12.644.276.374.465.510', 'D12.776.467.374.465.510', 'D23.529.374.465.510'], ['C10.114.375.500', 'C10.314.350.500', 'C20.111.258.250.500'], ['D12.644.276.374.687.100', 'D12.644.276.954.775.100', 'D12.776.467.374.687.100', 'D12... | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Pyeloureteral junction stenosis and ureteral valve causing hydronephrosis. | A young female patient underwent ureteral resection and Hynes-Anderson pyeloureteroplasty because of pyeloureteral junction stenosis and a ureteral valve (UV), which caused hydronephrosis. Despite using ultrasonography and intravenous urography the ureteral valve was observed only on exploration. UV should be considere... | ['Adult', 'Female', 'Humans', 'Hydronephrosis', 'Kidney Pelvis', 'Ureter', 'Ureteral Obstruction'] | 11,487,081 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.777.419.307', 'C13.351.968.419.307'], ['A05.810.453.537'], ['A05.810.776'], ['C12.777.725.776', 'C13.351.968.725.776']] | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
In vitro effect of orexin A on the transcriptomic profile of the endometrium during early pregnancy in pigs. | Orexin A belongs to the group of hypothalamic-derived peptides that are involved in a number of processes, such as regulation of energy metabolism, control of food intake and regulation of the reproductive system, by influencing the hypothalamic-pituitary-ovarian axis. Orexin A is also present in the endometrium, myome... | ['Animals', 'Cells, Cultured', 'Embryo Implantation', 'Endometrium', 'Female', 'Gestational Age', 'Orexins', 'Pregnancy', 'Pregnancy, Animal', 'Swine', 'Transcriptome'] | 30,545,750 | [['B01.050'], ['A11.251'], ['G08.686.784.170.104.500'], ['A05.360.319.679.490'], ['G07.345.500.325.235.968', 'G08.686.320'], ['D12.644.400.360', 'D12.776.631.650.363'], ['G08.686.784.769'], ['G08.686.784.769.498'], ['B01.050.150.900.649.313.500.880'], ['G02.111.873.750', 'G05.297.700.750', 'G05.360.920']] | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Suppression of NF-kappaB and AP-1 activation in monocytic cells persistently infected with measles virus. | A major cause of the high morbidity and mortality associated with measles infection is attributed to virus-mediated immunosuppression. In this report, we present evidence for a novel strategy of immunosuppression by the measles virus. We observed a marked suppression of lipopolysaccharide (LPS)-induced IL-8, RANTES, TN... | ['Cell Line', 'Down-Regulation', 'Humans', 'Measles', 'Measles virus', 'Monocytes', 'NF-kappa B', 'Transcription Factor AP-1'] | 17,196,632 | [['A11.251.210'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C01.925.782.580.600.500.500'], ['B04.820.480.937.600.650.500.500'], ['A11.118.637.555.652', 'A11.148.580', 'A11.627.624', 'A11.733.547', 'A15.145.229.637.555.652', 'A15.378.316.580', 'A15.382.490.555.... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Hypercapnic acidosis attenuates endotoxin-induced acute lung injury. | Deliberate induction of prophylactic hypercapnic acidosis protects against lung injury after in vivo ischemia-reperfusion and ventilation-induced lung injury. However, the efficacy of hypercapnic acidosis in sepsis, the commonest cause of clinical acute respiratory distress syndrome, is not known. We investigated wheth... | ['Acidosis, Respiratory', 'Analysis of Variance', 'Animals', 'Blood Gas Analysis', 'Disease Models, Animal', 'Endotoxins', 'Hypercapnia', 'Male', 'Primary Prevention', 'Probability', 'Pulmonary Gas Exchange', 'Random Allocation', 'Rats', 'Rats, Sprague-Dawley', 'Respiratory Distress Syndrome', 'Respiratory Insufficienc... | 12,958,048 | [['C08.618.846.093', 'C18.452.076.176.310'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['B01.050'], ['E01.370.225.124.100.100', 'E01.370.386.700.100', 'E05.200.124.100.100'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['D23.946.123.329'], ['C23.888.852.544'], ['N02.421.726.758', 'N06.850.78... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Mitochondrial function in the yeast form of the pathogenic fungus Paracoccidioides brasiliensis. | Differences between the respiratory chain of the fungus Paracoccidioides brasiliensis and its mammalian host are reported. Respiration, membrane potential, and oxidative phosphorylation in mitochondria from P. brasiliensis spheroplasts were evaluated in situ, and the presence of a complete (Complex I-V) functional resp... | ['Ascomycota', 'Cell Respiration', 'Membrane Potential, Mitochondrial', 'Mitochondria', 'Oxygen', 'Species Specificity'] | 18,797,987 | [['B01.300.107'], ['G03.197', 'G04.270'], ['G03.295.770.500', 'G04.580.550', 'G07.265.675.550'], ['A11.284.430.214.190.875.564', 'A11.284.835.626'], ['D01.268.185.550', 'D01.362.670'], ['G16.824']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Epidemiological explanation of an outbreak of gastro-enteritis in Sweden in the absence of detailed microbiological information. | Waterborne gastroenteritis outbreaks have often gone undetected or been incompletely defined in terms of source and extent. Methods which allow detection or clarification of such events are therefore useful. We describe the methods used to detect and investigate such an outbreak. In autumn 1996 high school absence rate... | ['Disease Outbreaks', 'Environmental Exposure', 'Gastroenteritis', 'Humans', 'Sweden', 'Water Microbiology', 'Water Supply'] | 9,849,833 | [['N06.850.290'], ['N06.850.460.350'], ['C06.405.205'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.542.816.500'], ['H01.158.273.540.274.777', 'N06.850.425.450'], ['J01.293.821.500']] | ['Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 |
The Clinical Features and Predisposing Factors of Asymptomatic Erosive Esophagitis. | BACKGROUND: Asymptomatic erosive esophagitis (AEE) is considered an erosive esophagitis without the typical reflux symptoms, but the clinical course and significance of AEE is still unclear.AIM: We investigated the prevalence and predisposing factors of AEE, and tried to determine its clinical features and significance... | ['Adult', 'Aged', 'Aged, 80 and over', 'Alcohol Drinking', 'Antibodies, Bacterial', 'Asymptomatic Diseases', 'Body Mass Index', 'Endoscopy, Digestive System', 'Esophagitis, Peptic', 'Female', 'Gastroesophageal Reflux', 'Helicobacter Infections', 'Helicobacter pylori', 'Hernia, Hiatal', 'Humans', 'Immunoglobulin G', 'Ma... | 27,796,766 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['F01.145.317.269'], ['D12.776.124.486.485.114.107', 'D12.776.124.790.651.114.125', 'D12.776.377.715.548.114.125'], ['C23.550.291.187'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['E01.370.372.250', 'E01.... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Experimental bacterial infection of the biliary tract. | The bacterial species commonly found in the human obstructed biliary tract were studied in an animal model of acute hepato-cholangitis. A rank order of their virulence and persistence in the bile and liver was shown which corresponded well to the clinical effects in the animals and also to the prevalence of bile bacter... | ['Animals', 'Bacteria', 'Bile', 'Cholangitis', 'Enterobacteriaceae', 'Female', 'Liver', 'Male', 'Pseudomonas aeruginosa', 'Rats', 'Time Factors', 'Virulence'] | 6,775,669 | [['B01.050'], ['B03'], ['A12.200.087'], ['C06.130.120.200'], ['B03.440.450.425', 'B03.660.250.150'], ['A03.620'], ['B03.440.400.425.625.625.100', 'B03.660.250.580.590.050'], ['B01.050.150.900.649.313.992.635.505.700'], ['G01.910.857'], ['G06.930']] | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Clinical significance of bcl2 and p53 protein expression in diffuse large B-cell lymphoma: a population-based study. | PURPOSE: We studied the prognostic significance of bcl2 and p53 protein expression in relation to clinical and pathologic characteristics in patients with diffuse large B-cell lymphoma (LCL).PATIENTS AND METHODS: Three hundred seventy-two patients with LCL were retrieved from a population-based registry for non-Hodgkin... | ['Adult', 'Aged', 'Aged, 80 and over', 'Biomarkers, Tumor', 'Disease-Free Survival', 'Female', 'Humans', 'Immunohistochemistry', 'Lymphoma, B-Cell', 'Lymphoma, Large B-Cell, Diffuse', 'Male', 'Middle Aged', 'Multivariate Analysis', 'Prognosis', 'Proto-Oncogene Proteins', 'Proto-Oncogene Proteins c-bcl-2', 'Risk Factors... | 8,683,246 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D23.101.140'], ['E01.789.800.190', 'E05.318.740.998.300', 'N04.761.559.590.800.190', 'N05.715.360.575.575.800.190', 'N05.715.360.750.795.300', 'N06.850.520.830.998.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.3... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Kinetic and thermodynamic characterization of DNA duplex-hairpin interconversion for two DNA decamers: d(CAACGGGTTG) and d(CAACCCGTTG). | The duplex-hairpin interconversion of two DNA decamers, d(CAACGGGTTG) and d(CAACCCGTTG), has been characterized thermodynamically and kinetically by using uv-melting and nmr relaxation methods. Separately, each decamer shows slow exchange between hairpin and duplex conformations. The hairpin conformations have melting ... | ['Base Sequence', 'DNA', 'Kinetics', 'Magnetic Resonance Spectroscopy', 'Molecular Sequence Data', 'Nucleic Acid Conformation', 'Nucleic Acid Heteroduplexes', 'Thermodynamics'] | 7,696,564 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D13.444.308'], ['G01.374.661', 'G02.111.490'], ['E05.196.867.519'], ['L01.453.245.667'], ['G02.111.570.820.486', 'G05.360.580'], ['D13.444.500'], ['G01.906']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Serum vitamin B12 levels in parturients, in the intervillous space of the placenta and in full-term newborns and their interrelationships with folate levels. | Serum vitamin B12 levels were determined in a group of 51 parturients as well as in their babies and placentas. The results obtained showed that newborns had 2.3 times higher vitamin B12 levels than their mothers and that the concentrations of this vitamin in the intervillous space of the placenta was 1.3- and 3.2-fold... | ['Female', 'Fetal Blood', 'Folic Acid', 'Humans', 'Infant, Newborn', 'Placenta', 'Pregnancy', 'Vitamin B 12'] | 3,969,940 | [['A12.207.152.200', 'A15.145.300', 'A16.378.200'], ['D03.633.100.733.631.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['A16.710'], ['G08.686.784.769'], ['D03.383.129.578.840.437.777', 'D03.633.400.909.437.777', 'D04.345.783.437.777']] | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Named Groups [M]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
NIR laser tissue welding of in vitro porcine cornea and sclera tissue. | BACKGROUND AND OBJECTIVE: The objective of this study was to test the hypothesis that an near infrared (NIR) laser system (1,455 nm) in combination with a motorized translational stage to control the position and speed of the laser beam and a shutter to control the laser exposure to the tissue being welded could be use... | ['Animals', 'Cornea', 'In Vitro Techniques', 'Laser Therapy', 'Sclera', 'Swine'] | 15,493,021 | [['B01.050'], ['A09.371.060.217'], ['E05.481'], ['E02.594', 'E04.014.520'], ['A09.371.784'], ['B01.050.150.900.649.313.500.880']] | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Postural coordination patterns as a function of rhythmical dynamics of the surface of support. | This study investigated the organization of postural coordination patterns as a function of the rhythmical dynamics of the surface of support. We examined how the number and nature of the dynamical degrees of freedom in the movement coordination patterns changed as a function of the amplitude and frequency of support s... | ['Adult', 'Female', 'Humans', 'Male', 'Periodicity', 'Postural Balance', 'Principal Component Analysis', 'Psychomotor Performance'] | 23,392,472 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.910.645', 'G07.180.562'], ['F02.830.816.541.752', 'G07.888.750.500', 'G11.427.690', 'G11.561.790.541.595'], ['E05.318.740.562'], ['F02.808', 'G11.427.700', 'G11.561.660']] | ['Named Groups [M]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Trypsin promotes C6 glioma cell proliferation in serum- and growth factor-free medium. | C6 glioma cells could be successively subcultured and maintained in serum- and growth factor-free medium (SF/GFF medium). C6 cell proliferation in SF/GFF medium was positively correlated with the initial cell density at plating. This correlation disappeared when the medium had been renewed early after cell adhesion (3 ... | ['Animals', 'Cell Division', 'Culture Media', 'Culture Media, Serum-Free', 'Glioma', 'Growth Substances', 'Rats', 'Trypsin', 'Tumor Cells, Cultured'] | 8,856,716 | [['B01.050'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['D27.720.470.305', 'E07.206'], ['D27.720.470.305.255', 'E07.206.255'], ['C04.557.465.625.600.380', 'C04.557.470.670.380', 'C04.557.580.625.600.380'], ['D27.505.696.377'], ['B01.050.150.900.649.313.992.635.505.700'], ['D08.811.277.6... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Robustness of a network formed by n interdependent networks with a one-to-one correspondence of dependent nodes. | Many real-world networks interact with and depend upon other networks. We develop an analytical framework for studying a network formed by n fully interdependent randomly connected networks, each composed of the same number of nodes N. The dependency links connecting nodes from different networks establish a unique one... | ['Computer Simulation', 'Models, Biological', 'Models, Theoretical'] | 23,005,189 | [['L01.224.160'], ['E05.599.395'], ['E05.599']] | ['Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Can rectal endoscopic sonography be used to predict infiltration depth in patients with deep infiltrating endometriosis of the rectum? | OBJECTIVES: To evaluate the diagnostic accuracy of rectal endoscopic sonography (RES) in the prediction of the infiltration depth of rectal endometriosis and to ascertain whether RES could be used to choose between segmental bowel resection and a more conservative approach, such as shaving or discoid resection.METHODS:... | ['Adult', 'Endometriosis', 'Endosonography', 'Female', 'Humans', 'Laparoscopy', 'Middle Aged', 'Predictive Value of Tests', 'Rectal Diseases', 'Retrospective Studies', 'Sensitivity and Specificity'] | 23,754,206 | [['M01.060.116'], ['C13.351.500.163'], ['E01.370.350.850.280'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.388.250.520', 'E04.502.250.520'], ['M01.060.116.630'], ['E05.318.370.800.650', 'N05.715.360.325.700.640', 'N06.850.520.445.800.650'], ['C06.405.469.860'], ['E05.318.372.500.500.500', 'E05.318.372.5... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
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