Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Impact of Lactobacillus acidophilus on the normal intestinal microflora after administration of two antimicrobial agents. | Twenty healthy volunteers participated in a comparative study concerning the influence of Lactobacillus acidophilus supplements on the normal intestinal microflora after the administration of two antimicrobial agents, enoxacin and clindamycin, respectively. L. acidophilus NCFB 1748 was given as a fermented milk product... | ['Adult', 'Clindamycin', 'Colon', 'Enoxacin', 'Feces', 'Female', 'Gram-Negative Aerobic Bacteria', 'Gram-Negative Anaerobic Bacteria', 'Humans', 'Lactobacillus acidophilus', 'Male', 'Middle Aged'] | 3,146,551 | [['M01.060.116'], ['D03.383.773.532.500.125', 'D09.408.471.500.125'], ['A03.556.124.526.356', 'A03.556.249.249.356'], ['D03.633.100.810.835.322.280'], ['A12.459'], ['B03.440.400'], ['B03.440.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B03.353.750.450.475.100', 'B03.510.460.400.410.475.475.100', 'B03.510.5... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Phantom limb pain and residual limb pain following lower limb amputation: a descriptive analysis. | PURPOSE: This research aimed to develop a clearer picture of the experience of residual limb pain and phantom limb pain following a lower limb amputation and to gain a greater understanding of their relationships with physical and psychosocial variables.METHOD: One hundred and four participants completed the Trinity Am... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Amputation', 'Female', 'Humans', 'Male', 'Middle Aged', 'Phantom Limb'] | 11,432,649 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E04.555.080'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C10.597.606.762.700', 'C23.550.767.700.500', 'C23.888.592.604.764.700', 'C23.888.592.612.832.500', 'F01.700.750.700']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Quantification of power Doppler energy and its future potential. | OBJECTIVE: To test a new software package (Color Quantifier, Kinetic Imaging, Liverpool, United Kingdom) that quantifies power Doppler energy and to determine its reproducibility.DESIGN: Intraobserver and interobserver reproducibility study.SETTING: University tertiary referral center.PATIENT(S): Transvaginal power Dop... | ['Analysis of Variance', 'Endometrium', 'Female', 'Humans', 'Menstrual Cycle', 'Observer Variation', 'Ovarian Follicle', 'Ovary', 'Reproducibility of Results', 'Software', 'Ultrasonography, Doppler, Color', 'Uterus', 'Vagina'] | 11,532,485 | [['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['A05.360.319.679.490'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G08.686.605'], ['E01.354.753', 'N02.421.450.600', 'N05.715.350.150.675', 'N06.850.490.500.250'], ['A05.360.319.114.630.535', 'A06.300.312.497.535'], ['A05.360.319.114.630', 'A0... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Mechanistic Insights into the Carbon Dioxide/Cyclohexene Oxide Copolymerization Reaction: Is One Metal Center Enough? | A detailed study on the mechanism for the alternating copolymerization of cyclohexene oxide (CHO) and CO2 mediated by an [Al{amino-tri(phenolate)}]/NBu4 I binary catalyst system was performed by using DFT-based methods. Four potential mechanisms (one monometallic and three bimetallic) were considered for the first prop... | ['Aluminum', 'Carbon Dioxide', 'Catalysis', 'Cyclohexenes', 'Epoxy Compounds', 'Models, Molecular', 'Molecular Conformation', 'Organometallic Compounds', 'Polymerization', 'Quantum Theory', 'Thermodynamics'] | 27,957,819 | [['D01.268.557.050', 'D01.552.547.050'], ['D01.200.200', 'D01.362.150', 'D01.650.550.200'], ['G02.130'], ['D02.455.426.392.368.367.379'], ['D02.355.291.411'], ['E05.599.595'], ['G02.111.570.820'], ['D02.691'], ['G02.750'], ['H01.671.579.800'], ['G01.906']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
One hundred consecutive thymectomies for myasthenia gravis. | BACKGROUND: Between June 1997 and November 1993, 100 consecutive thymectomies for myasthenia gravis were performed at University of North Carolina Hospitals in Chapel Hill.METHODS: A consistent, planned protocol involving preoperative, intraoperative, and postoperative care was followed. All thymectomies were performed... | ['Adult', 'Female', 'Follow-Up Studies', 'Humans', 'Length of Stay', 'Male', 'Morbidity', 'Myasthenia Gravis', 'Postoperative Complications', 'Severity of Illness Index', 'Sternum', 'Thymectomy', 'Time Factors'] | 8,678,650 | [['M01.060.116'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.760.400.480', 'N02.421.585.400.480'], ['E05.318.308.985.525', 'N01.224.935.597', 'N06.850.505.400.975.525', 'N06.850.520.308.985.525'], ['C04.588.614.550.50... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Dynamics of forward and reverse transport by the glial glycine transporter, glyt1b. | Glycine is a coagonist at the N-methyl-D-aspartate receptor. Changes in extracellular glycine concentration may modulate N-methyl-D-aspartate receptor function and excitatory synaptic transmission. The GLYT1 glycine transporter is present in glia surrounding excitatory synapses, and plays a key role in regulating extra... | ['Animals', 'Biological Transport', 'Biophysics', 'CHO Cells', 'Cricetinae', 'Dose-Response Relationship, Drug', 'GABA Plasma Membrane Transport Proteins', 'Glycine', 'Glycine Plasma Membrane Transport Proteins', 'Kinetics', 'Models, Biological', 'Patch-Clamp Techniques', 'Receptors, N-Methyl-D-Aspartate', 'Sodium', 'S... | 15,951,392 | [['B01.050'], ['G03.143'], ['H01.158.344', 'H01.671.100'], ['A11.251.210.200', 'A11.436.155'], ['B01.050.150.900.649.313.992.635.075.250'], ['G07.690.773.875', 'G07.690.936.500'], ['D12.776.157.530.450.625.139', 'D12.776.157.530.562.374.750', 'D12.776.543.585.450.625.139', 'D12.776.543.585.562.374.750'], ['D12.125.481'... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Interferon induction by transfection of Sendai virus C gene cDNA. | To elucidate the mechanism of interferon (IFN) induction on virus infection, we constructed two types of plasmids by inserting a part of the cDNA of the Sendai virus into a simian virus 40-derived expression vector (pSV2-0). One, pSV2-PC, contained the P + C gene, which codes for the P and C proteins in overlapping rea... | ['Animals', 'Cell Line', 'DNA', 'Genes, Viral', 'Interferon Inducers', 'Interferon Type I', 'L Cells', 'Mice', 'Parainfluenza Virus 1, Human', 'Plasmids', 'Transfection'] | 3,027,393 | [['B01.050'], ['A11.251.210'], ['D13.444.308'], ['G05.360.340.024.340.364.875', 'G05.360.340.358.024.875', 'G05.360.340.358.840.500'], ['D27.505.696.477.828'], ['D12.644.276.374.440.890', 'D12.776.467.374.440.890', 'D23.529.374.440.890'], ['A11.251.210.505', 'A11.329.228.505'], ['B01.050.150.900.649.313.992.635.505.500... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Imprecise exposure assessment and the sample size requirements of case-control studies of residential magnetic field exposure and cancer in adults. | A computer program simulating case-control studies is described. It is used to estimate the minimum sample size required and to assess how this is affected by imprecise exposure assessment. In particular, the consequences of neglecting measurements of nonresidential exposure in case-control studies of residentially exp... | ['Adult', 'Algorithms', 'Breast Neoplasms', 'Case-Control Studies', 'Computer Simulation', 'Electromagnetic Fields', 'Environmental Exposure', 'Female', 'Forecasting', 'Housing', 'Humans', 'Magnetics', 'Models, Biological', 'Models, Statistical', 'Neoplasms, Radiation-Induced', 'Risk Factors', 'Sample Size', 'Sensitivi... | 7,612,028 | [['M01.060.116'], ['G17.035', 'L01.224.050'], ['C04.588.180', 'C17.800.090.500'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['L01.224.160'], ['G01.358.500.260', 'G01.358.750.500'], ['N06.850.460.350'], ['I01.320'], ['J03.340', 'N01.224.791.400', 'N06.230.150.360', 'N06.850.505.400.8... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Discipl... | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
Platelet-activating factor-induced homologous and heterologous desensitization in cultured vascular smooth muscle cells. | Intracellular free Ca2+ concentrations were monitored in vascular smooth muscle cells (VSMC) using the Ca2+-sensitive dye fura II. Superfusion of VSMC with platelet-activating factor (S-PAF; 1-100 nM) increased cytosolic Ca2+ in a dose-dependent manner. The response was transient and returned to base line even though t... | ['Angiotensin II', 'Animals', 'Aorta', 'Benzofurans', 'Calcium', 'Cells, Cultured', 'Cytosol', 'Diglycerides', 'Fluorescent Dyes', 'Fura-2', 'Inositol 1,4,5-Trisphosphate', 'Inositol Phosphates', 'Male', 'Muscle, Smooth, Vascular', 'Platelet Activating Factor', 'Rats', 'Rats, Inbred Strains', 'Spectrometry, Fluorescenc... | 3,262,105 | [['D06.472.699.094.078', 'D12.644.400.070.078', 'D12.644.456.073.041', 'D12.644.548.058.078', 'D12.776.631.650.070.078', 'D23.469.050.050.050'], ['B01.050'], ['A07.015.114.056'], ['D03.633.100.127'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['A11.251'], ['A11.284.430.214.200', 'A11.284.430.429.200', 'A11.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Introducing ethical evaluation of the use of animals in experiments in the Near East. | Turkey and Iran are two Near East countries that are developing ethical regulation systems for animal experiments, following significant developments in this field in neighbouring Europe. In Turkey, legislation was passed between 2004 and 2006 to mandate ethical review of experiments which involve the use of laboratory... | ['Animal Experimentation', 'Animal Testing Alternatives', 'Animal Welfare', 'Animals', 'Iran', 'Islam', 'Middle East', 'Turkey'] | 20,822,325 | [['E05.017', 'H01.770.644.053'], ['E05.017.080.100'], ['I01.880.604.100'], ['B01.050'], ['Z01.252.245.500.350'], ['K01.844.275'], ['Z01.252.245.500'], ['Z01.252.245.500.850']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Geographicals [Z]', 'Humanities [K]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 |
Some concluding thoughts on the debate about the Vividness of Visual Imagery Questionnaire. | The case for the validity of the Vividness of Visual Imagery Questionnaire is examined. It is argued that the validity of the questionnaire is not established in the literature and that paradigmatic and conceptual ambiguity militate against a clear understanding of that literature. Phenomenological problems with questi... | ['Humans', 'Imagination', 'Judgment', 'Memory', 'Reproducibility of Results', 'Surveys and Questionnaires'] | 1,454,501 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.188.634'], ['F02.463.785.626'], ['F02.463.425.540'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980']] | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[Subclinical varicocele: detection using Doppler and thermography]. | We think that we must find out a varicocele in every case of oligospermia, asthenospermia and teratospermia, particularly with spindle-shaped spermatozoa. If the clinical examination remains negative, it is necessary to provoke a backflow at the Doppler by carrying out a Valsalva's maneuver. If the obtained result is p... | ['Humans', 'Male', 'Sperm Count', 'Thermography', 'Ultrasonography', 'Varicocele'] | 7,287,470 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.195.870', 'E01.370.225.992.624', 'E05.200.500.195.870', 'E05.200.992.624', 'E05.242.195.870', 'G04.140.870'], ['E01.370.350.800', 'E05.933.500'], ['E01.370.350.850'], ['C12.294.936', 'C14.907.903']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Radioimmunotherapy: clinical results and dosimetric considerations. | Radiolabeled antibodies for cancer therapy are being investigated in clinical trials in more than 30 centers. 131Iodine-labeled antibody (Ab) therapy of solid tumors has produced few responses when given alone. When given in conjunction with chemotherapy and external beam therapy in hepatoma patients, objective respons... | ['Humans', 'Meta-Analysis as Topic', 'Neoplasms', 'Radiation Dosage', 'Radioimmunotherapy'] | 1,534,796 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.370.500', 'E05.581.500.501', 'N05.715.360.325.515', 'N06.850.520.445.500'], ['C04'], ['E05.799.513', 'G01.750.740', 'N06.850.810.250'], ['E02.095.465.425.750', 'E02.186.750', 'E02.815.520']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Expression of low-frequency Ala108Pro substitution in the platelet glycoprotein Ibbeta gene. | We determined the gene frequency of the glycoprotein (GP) Ibbeta Ala108Pro substitution. The Pro108 allele was not found in 208 healthy Japanese and 200 healthy Caucasians. In vitro expression studies showed surface expression of the GPIbbeta Pro108 variant, suggesting the possibility of the involvement of the substitu... | ['Amino Acid Substitution', 'Humans', 'Platelet Glycoprotein GPIb-IX Complex'] | 12,648,286 | [['E05.393.420.601.035', 'G05.558.109'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.395.550.625.460', 'D12.776.543.550.625.460', 'D12.776.543.750.705.675.568']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Ultrastable, redispersible, small, and highly organomodified mesoporous silica nanotherapeutics. | Practical biomedical application of mesoporous silica nanoparticles is limited by poor particle dispersity and stability due to serious irreversible aggregation in biological media. To solve this problem, hydrothermally treated mesoporous silica nanoparticles of small size with dual-organosilane (hydrophilic and hydrop... | ['Magnetic Resonance Spectroscopy', 'Microscopy, Electron, Transmission', 'Nanotechnology', 'Silicon Dioxide', 'X-Ray Diffraction'] | 22,050,408 | [['E05.196.867.519'], ['E01.370.350.515.402.580', 'E05.595.402.580'], ['H01.603', 'J01.897.520.600'], ['D01.578.750', 'D01.650.550.825', 'D01.837.725'], ['E05.196.309.742', 'E05.196.822.950', 'G01.867.950', 'G02.965']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Bioluminescence Imaging as a Tool for Poxvirus Biology. | Bioluminescence imaging, with luciferase as a reporter-encoding gene, has been successfully and widely used for studies to follow viral infection in an organism and to measure therapeutic efficacy of antiviral agents in small animal models. Bioluminescence is produced by the reaction of a luciferase enzyme stably inser... | ['Animals', 'Antiviral Agents', 'Humans', 'Luminescent Measurements', 'Poxviridae', 'Virus Diseases'] | 31,240,684 | [['B01.050'], ['D27.505.954.122.388'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.196.712.516'], ['B04.280.650'], ['C01.925']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Work sampling. Analyzing nursing staff productivity. | Most managers have only a vague idea of how their employees spend their time. Work sampling is a technique that can identify the types of activities that staff perform and the amount of time that they spend on each activity. With this information, managers can make decisions regarding allocation of staff and activities... | ['Data Collection', 'Efficiency', 'Hospital Bed Capacity, 500 and over', 'Humans', 'Michigan', 'Nurse Administrators', 'Nursing Service, Hospital', 'Planning Techniques', 'Psychiatric Department, Hospital', 'Time and Motion Studies', 'Work'] | 3,897,485 | [['E05.318.308', 'L01.399.250', 'N05.715.360.300', 'N06.850.520.308'], ['F02.784.692.351', 'N04.452.209'], ['N02.278.306.472.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.107.567.875.350.500', 'Z01.107.567.875.510.500'], ['M01.526.070.670', 'M01.526.485.650.580', 'N02.360.650.580'], ['N02.278.216.500.96... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Geographicals [Z]', 'Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
Seroprevalence of pertussis among children in Eastern Turkey. | The aim of this cross-sectional study was to determine the immunity status of children to pertussis by socio-demographic characteristics in Eastern Turkey. The study sample consisted of 840 randomly selected and healthy children aged 0-71 months. The seroprevalence of pertussis was 30.1%. Age, parent education and econ... | ['Antibody Formation', 'Child, Preschool', 'Cross-Sectional Studies', 'Diphtheria-Tetanus-Pertussis Vaccine', 'Female', 'Humans', 'Immunization', 'Infant', 'Infant, Newborn', 'Male', 'Risk Factors', 'Seroepidemiologic Studies', 'Socioeconomic Factors', 'Turkey', 'Whooping Cough'] | 15,826,897 | [['G12.450.050.370.250'], ['M01.060.406.448'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['D20.215.894.135.535.300', 'D20.215.894.691.263.300', 'D20.215.894.691.824.300', 'D20.215.894.815.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.095.465.425.400', 'E05.478.550', ... | ['Phenomena and Processes [G]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Dynamic physiological temperature and pressure sensing with phase-resolved low-coherence interferometry. | We report the development and characterisation of highly miniaturised fibre-optic sensors for simultaneous pressure and temperature measurement, and a compact interrogation system with a high sampling rate. The sensors, which have a maximum diameter of 250 µm, are based on multiple low-finesse optical cavities formed f... | ['Equipment Design', 'Fiber Optic Technology', 'Interferometry', 'Optical Fibers', 'Pressure', 'Temperature', 'Transducers'] | 30,876,162 | [['E05.320'], ['H01.671.617.249'], ['E05.490'], ['E07.632.750'], ['G01.374.715'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.150.450', 'N06.230.300.100.725.710'], ['E07.305.812']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Effect of heparin on the biological properties and molecular signature of human mesenchymal stem cells. | Chronic use of heparin as an anti-coagulant for the treatment of thrombosis or embolism invokes many adverse systemic events including thrombocytopenia, vascular reactions and osteoporosis. Here, we addressed whether adverse effects might also be directed to mesenchymal stem cells that reside in the bone marrow compart... | ['Bone Marrow Cells', 'Cell Differentiation', 'Cell Proliferation', 'Cells, Cultured', 'Culture Media', 'Dose-Response Relationship, Drug', 'Gene Expression Regulation', 'Heparin', 'Humans', 'Mesenchymal Stem Cells', 'Signal Transduction'] | 26,484,394 | [['A11.148', 'A15.378.316'], ['G04.152'], ['G04.161.750', 'G07.345.249.410.750'], ['A11.251'], ['D27.720.470.305', 'E07.206'], ['G07.690.773.875', 'G07.690.936.500'], ['G05.308'], ['D09.698.373.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.329.830.500', 'A11.872.590.500'], ['G02.111.820', 'G04.835']] | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Enhanced production of biosynthesized lycopene via heterogenous MVA pathway based on chromosomal multiple position integration strategy plus plasmid systems in Escherichia coli. | The multiple plasmid system, mostly relied, for heterogeneous gene expression, results in genetic instability and low mean productivity. To address this, an integration method was employed for investigating expression of heterogenous pathway in E. coli cells; where mevalonate upper pathway was found efficiently express... | ['Carotenoids', 'Escherichia coli', 'Lycopene', 'Mevalonic Acid', 'Plasmids'] | 29,195,149 | [['D02.455.326.271.665.202', 'D02.455.426.392.368.367.379.249', 'D02.455.849.131', 'D23.767.261'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D02.455.326.271.665.202.216', 'D02.455.426.392.368.367.379.249.213', 'D02.455.849.131.216', 'D23.767.261.375'], ['D02.241.511.579'], ['G05.360.600']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Influence of a titanium mesh on the management of segmental long bone defects. An experimental study in a canine ulnar model. | OBJECTIVES: To evaluate the influence of titanium mesh on guided bone regeneration when used, either alone or in combination with autogenous bone block graft, in a canine ulnar model.METHODS: Thirty-two, purpose bred, adult, castrated male Beagles were used, divided into four equal-size groups. A unilateral mid-diaphys... | ['Animals', 'Biomechanical Phenomena', 'Bone Regeneration', 'Dogs', 'Forelimb', 'Internal Fixators', 'Male', 'Osseointegration', 'Surgical Mesh', 'Titanium'] | 26,449,275 | [['B01.050'], ['G01.154.090', 'G01.374.089'], ['G11.427.213.140', 'G16.762.150.150'], ['B01.050.150.900.649.313.750.250.216.200'], ['A13.395'], ['E07.695.370', 'E07.858.442.660.460', 'E07.858.690.725.460'], ['G11.427.213.140.570', 'G16.762.150.150.570'], ['E07.858.708'], ['D01.268.557.800', 'D01.268.956.878', 'D01.552.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
When should expanded criteria donor kidneys be used for single versus dual kidney transplants? | BACKGROUND: To increase the utilization of cadaveric donor kidneys, we have recently expanded our acceptable criteria to include aged donors (frequently with a history of hypertension), by selectively using both donor kidneys (dual transplant) into a single recipient.METHODS: To define when these expanded criteria dono... | ['Adult', 'Aged', 'Cadaver', 'Cold Temperature', 'Creatinine', 'Humans', 'Kidney', 'Kidney Transplantation', 'Middle Aged', 'Organ Preservation', 'Regression Analysis', 'Retrospective Studies', 'Tissue Donors', 'Tissue and Organ Procurement', 'Treatment Outcome'] | 9,355,831 | [['M01.060.116'], ['M01.060.116.100'], ['C23.550.260.224'], ['G01.906.595.272', 'G16.500.275.063.725.710.300', 'G16.500.750.775.710.300', 'N06.230.300.100.725.154', 'N06.230.300.100.725.710.300'], ['D03.383.129.308.207'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A05.810.453'], ['E02.870.500', 'E04.936.450.485... | ['Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Consumer sensory evaluations of aging effects on beef quality. | The most important sensory attribute affecting consumer acceptability is tenderness, which is a complex trait. Aging is the practice of holding meat at low temperatures to improve tenderness. In order to assess consumer quality attributes, cattle were selected to represent a range of quality grades from Utility to Prim... | ['Animals', 'Cattle', 'Consumer Behavior', 'Food Handling', 'Humans', 'Hydrogen-Ion Concentration', 'Lipids', 'Meat', 'Muscle, Skeletal', 'Quality Control', 'Temperature', 'Time Factors', 'Water'] | 18,211,374 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['F01.145.236'], ['J01.576.423.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.300'], ['D10'], ['G07.203.300.600', 'J02.500.600'], ['A02.633.567', 'A10.690.552.500'], ['J01.897.608'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', '... | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Prevalence and risk factors of urinary incontinence and its influence on the quality of life of Japanese women. | Urinary incontinence is a common problem as women age. The aims of this study were to assess the prevalence and risk factors of urinary incontinence and their impact on the quality of life of working Japanese women. In this cross-sectional study, 975 women completed the Urogenital Distress Inventory-6, the Short Form (... | ['Adult', 'Aged', 'Body Mass Index', 'Cross-Sectional Studies', 'Female', 'Health Knowledge, Attitudes, Practice', 'Health Surveys', 'Humans', 'Japan', 'Middle Aged', 'Prevalence', 'Quality of Life', 'Risk Factors', 'Surveys and Questionnaires', 'Urinary Incontinence'] | 18,466,389 | [['M01.060.116'], ['M01.060.116.100'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['F01.100.150.500', 'N05.300.150.410'], ['E05.318.308.980.438', 'N05.715.360.300.800.438', 'N06.850.520.308.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Distinct roles of CTLA-4 and TGF-beta in CD4+CD25+ regulatory T cell function. | Both CTLA-4 and TGF-beta have been implicated in suppression by CD4+CD25+ regulatory T cells (Treg). In this study, the relationship between CTLA-4 and TGF-beta in Treg function was examined. Blocking CTLA-4 on wild-type Treg abrogated their suppressive activity in vitro, whereas neutralizing TGF-beta had no effect, su... | ['Animals', 'Antigens, CD', 'Antigens, Differentiation', 'Blotting, Western', 'CD4-Positive T-Lymphocytes', 'CTLA-4 Antigen', 'Interleukin-10', 'L-Selectin', 'Lymphocyte Subsets', 'Mice', 'Mice, Inbred C57BL', 'Mice, Knockout', 'Mice, Transgenic', 'RNA', 'Receptors, Interleukin-2', 'Reverse Transcriptase Polymerase Cha... | 15,468,055 | [['B01.050'], ['D23.050.301.264.035', 'D23.101.100.110'], ['D23.050.301.264', 'D23.101.100'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['A11.118.637.555.567.569.200', 'A15.145.229.637.555.567.569.200', 'A15.382.490.555.567.569.200'], ['D12.776.465.782', 'D12.7... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Methods for analysis and visualization of SNP genotype data for complex diseases. | SNP markers are becoming central for studying genetic determinants of complex diseases. Large SNP data collected in such studies call for the development of specialized analysis tools. We present methods for selecting sets of SNPs that can be associated to sample properties in case/control studies. We also describe how... | ['Bayes Theorem', 'Case-Control Studies', 'Chromosomes, Human, Pair 15', 'Chromosomes, Human, Pair 2', 'Chromosomes, Human, Pair 7', 'Computational Biology', 'Computer Graphics', 'Data Interpretation, Statistical', 'Diabetes Mellitus, Type 2', 'Genotype', 'Humans', 'Mexican Americans', 'Polymorphism, Single Nucleotide'... | 12,603,057 | [['E05.318.740.600.200', 'N05.715.360.750.625.150', 'N06.850.520.830.600.200'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['A11.284.187.520.300.370.385', 'G05.360.162.520.300.370.385'], ['A11.284.187.520.300.235.245', 'G05.360.162.520.300.235.245'], ['A11.284.187.520.300.325.335', '... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Information Science [L]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 |
[Pituitary system with special reference to pituitary antibodies]. | Amino et al. postulated a postpartum autoimmune thyroid syndrome and Sugiura et al. established an assay for detecting antibodies to anterior pituitary cell surface membrane (PCSA) by immunofluorescent methods. Using this technique, we attempted to determine the prevalence of PCSA before and after delivery. Studies wer... | ['Animals', 'Autoantibodies', 'Cell Membrane', 'Female', 'Fluorescent Antibody Technique', 'Humans', 'Mice', 'Pituitary Gland, Anterior', 'Postpartum Period', 'Pregnancy', 'Rats', 'Thyroiditis, Autoimmune'] | 8,361,014 | [['B01.050'], ['D12.776.124.486.485.114.323', 'D12.776.124.790.651.114.323', 'D12.776.377.715.548.114.323'], ['A11.284.149'], ['E01.370.225.500.607.512.240', 'E01.370.225.750.551.512.240', 'E05.200.500.607.512.240', 'E05.200.750.551.512.240', 'E05.478.583.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.05... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Human prochymase activation. A novel role for heparin in zymogen processing. | Human prochymase is packaged with heparin in mast cell granules and appears to be activated by dipeptidylpeptidase I. We show that a high affinity interaction between heparin and prochymase allows the 2-residue propeptide to be cleaved by dipeptidylpeptidase I. A conserved Glu in the propeptide is necessary for this he... | ['Amino Acid Sequence', 'Base Sequence', 'Chymases', 'DNA Primers', 'Dipeptidyl-Peptidases and Tripeptidyl-Peptidases', 'Enzyme Activation', 'Enzyme Precursors', 'Heparin', 'Humans', 'In Vitro Techniques', 'Kinetics', 'Molecular Sequence Data', 'Mutagenesis, Site-Directed', 'Serine Endopeptidases', 'Structure-Activity ... | 7,836,453 | [['G02.111.570.060', 'L01.453.245.667.060'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D08.811.277.656.300.760.103', 'D08.811.277.656.959.350.103'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['D08.811.277.656.350.350'], ['G02.111.263', 'G03.328'], ['D08.622', 'D12.776.811.243'], ['D... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Layers of the abdominal wall: anatomical investigation of subcutaneous tissue and superficial fascia. | INTRODUCTION: In recent times new surgical approaches have been developed, in which subcutaneous tissue is the primary object, such as flaps and fat removal techniques, but different descriptions and abundance of terminology persist in Literature about this tissue.AIM AND METHODS: In order to investigate the structure ... | ['Abdominal Wall', 'Aged', 'Aged, 80 and over', 'Fascia', 'Female', 'Humans', 'Male', 'Middle Aged', 'Radiography', 'Subcutaneous Fat, Abdominal'] | 21,212,951 | [['A01.923.047.050'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['A02.340', 'A10.165.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.370.350.700'], ['A10.165.114.830.500.750', 'A10.165.114.830.750.500']] | ['Anatomy [A]', 'Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Relationship between duration of type 2 diabetes and self-reported participation in diabetes education in Korea. | The increasing prevalence of diabetes is a pressing issue in Korea. The aim of this study was to determine the relationship between duration of diabetes and self-reported participation in diabetes education among diabetic patients in Korea. This study used data from the Korean National Health and Nutrition Examination ... | ['Adult', 'Aged', 'Diabetes Mellitus, Type 2', 'Female', 'Health Education', 'Humans', 'Logistic Models', 'Male', 'Middle Aged', 'Nutrition Surveys', 'Odds Ratio', 'Patient Education as Topic', 'Prevalence', 'Republic of Korea', 'Self Care', 'Social Class', 'Surveys and Questionnaires', 'Young Adult'] | 22,500,039 | [['M01.060.116'], ['M01.060.116.100'], ['C18.452.394.750.149', 'C19.246.300'], ['I02.233.332', 'N02.421.726.407'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.525', 'E05.318.740.600.800.450', 'E05.318.740.750.450', 'E05.599.835.875', 'N05.715.360.750.530.480', 'N05.715.360.750.625.700.450', 'N05.... | ['Named Groups [M]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Tiotropium and salmeterol/fluticasone combination do not cause oxygen desaturation in COPD. | It has been documented that tiotropium is less likely to induce oxygen desaturation in stable COPD patients compared to long-acting beta2-agonists (LABAs) and combined administration of a LABA and an inhaled corticosteroid (ICS) reduces the potential for acute effects of LABA on blood-gas tensions. In this study, we ha... | ['Adrenergic beta-Agonists', 'Albuterol', 'Androstadienes', 'Anti-Inflammatory Agents', 'Bronchodilator Agents', 'Carbon Dioxide', 'Cross-Over Studies', 'Drug Combinations', 'Fluticasone', 'Forced Expiratory Volume', 'Humans', 'Oxygen', 'Partial Pressure', 'Pulmonary Disease, Chronic Obstructive', 'Salmeterol Xinafoate... | 18,343,646 | [['D27.505.519.625.050.100.200', 'D27.505.696.577.050.100.200'], ['D02.033.100.291.057', 'D02.092.063.291.057', 'D02.092.471.683.061'], ['D04.210.500.054.079.129'], ['D27.505.954.158'], ['D27.505.696.663.050.110', 'D27.505.954.796.050.100'], ['D01.200.200', 'D01.362.150', 'D01.650.550.200'], ['E05.318.370.150', 'N05.71... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Age-dependent enzymatic poly (A) metabolism in quail oviduct. | The poly(A) metabolism in oviducts from adult and senescent quails has been studied. The incorporation studies by double-labelling of mRNA with [3H]adenosine and [3H]uridine revealed, that after inhibition of transcription by actinomycin D, the incorporation ratio adenosine/uridine increases drastically in adult animal... | ['Adenosine', 'Aging', 'Animals', 'Avidin', 'Coturnix', 'Dactinomycin', 'Female', 'Oviducts', 'Poly A', 'Polynucleotide Adenylyltransferase', 'Progesterone', 'RNA, Messenger', 'Ribonucleases', 'Uridine'] | 428,737 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Less pain after transvaginal/transumbilical cholecystectomy than after the classical laparoscopic technique: short-term results of a matched-cohort study. | BACKGROUND: Natural orifice surgery (NOS) is gaining acceptance as an alternative to the traditional laparoscopic technique, especially for cholecystectomy through the transvaginal route. However, NOS remains controversial concerning expected advantages in terms of short- and long-term outcomes and potential side effec... | ['Adult', 'Aged', 'Cholecystectomy', 'Cholecystectomy, Laparoscopic', 'Cohort Studies', 'Female', 'Humans', 'Laparoscopy', 'Middle Aged', 'Natural Orifice Endoscopic Surgery', 'Pain, Postoperative', 'Prospective Studies', 'Time Factors', 'Treatment Outcome', 'Umbilicus', 'Vagina', 'Young Adult'] | 22,926,893 | [['M01.060.116'], ['M01.060.116.100'], ['E04.210.120.172'], ['E04.210.120.172.140', 'E04.502.250.520.160'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.388.250.520', 'E04.502.250.520'], ['M01.060.116.630'], ['E01.370.388.250.6... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
PMA increases M3 muscarinic receptor levels and decreases retinal cells proliferation through a change in the levels of cell-cycle regulatory proteins. | Protein kinase C (PKC) pathway plays important roles in different phenomena in nervous system development. Our previous data demonstrated that phorbol 12-myristate 13-acetate (PMA) treatment, a PKC activator, for 48 h decreases retinal cells proliferation by a mechanism mediated by muscarinic receptor activation, invol... | ['Animals', 'Cell Proliferation', 'Cells, Cultured', 'Cyclin D1', 'Cyclin-Dependent Kinase Inhibitor p21', 'Phorbol Esters', 'Rats', 'Receptor, Muscarinic M3', 'Retinal Neurons', 'Tumor Suppressor Protein p53'] | 23,827,230 | [['B01.050'], ['G04.161.750', 'G07.345.249.410.750'], ['A11.251'], ['D12.644.360.262.150.100', 'D12.776.167.218.150.100', 'D12.776.476.262.150.100', 'D12.776.624.664.700.100'], ['D12.644.360.225.500', 'D12.776.157.687.250', 'D12.776.167.187.500', 'D12.776.476.225.500', 'D12.776.624.776.355.500', 'D12.776.660.720.250'],... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Metal and redox selectivity of protoporphyrin binding to the heme chaperone CcmE. | The interaction of heme with the heme chaperone CcmE is central to our understanding of cytochrome c maturation, a complex post-translational process involving at least eight proteins in many Gram-negative bacteria and plant mitochondria. We have shown previously that Escherichia coli CcmE can interact with heme non-co... | ['Bacterial Outer Membrane Proteins', 'Cobalt', 'Escherichia coli', 'Escherichia coli Proteins', 'Hemeproteins', 'Manganese', 'Metals', 'Models, Molecular', 'Oxidation-Reduction', 'Protein Binding', 'Protoporphyrins', 'Tin', 'Zinc'] | 21,283,867 | [['D12.776.097.120', 'D12.776.543.100'], ['D01.268.556.185', 'D01.268.956.155', 'D01.552.544.185'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D12.776.097.275'], ['D12.776.422'], ['D01.268.556.484', 'D01.268.956.374', 'D01.552.544.484'], ['D01.552'], ['E05.599.595'], ['G02.700', 'G03.295.531'], ['G02.111... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
High serum haptoglobin level is associated with tumor progression and predicts poor prognosis in non-small cell lung cancer. | The overall survival time of non-small cell lung cancer (NSCLC) has not improved dramatically in recent decades. An important reason is the lacking of valuable biomarkers. Haptoglobin was reported to have activities of anti-inflammatory, anti-oxidant, autoimmune and tumor angiogenesis. However its potential role as a t... | ['Aged', 'Biomarkers, Tumor', 'Carcinoma, Non-Small-Cell Lung', 'Disease Progression', 'Female', 'Haptoglobins', 'Humans', 'Kaplan-Meier Estimate', 'Lung Neoplasms', 'Male', 'Middle Aged', 'Multivariate Analysis', 'Predictive Value of Tests', 'Prognosis', 'ROC Curve'] | 27,248,178 | [['M01.060.116.100'], ['D23.101.140'], ['C04.588.894.797.520.109.220.249', 'C08.381.540.140.500', 'C08.785.520.100.220.500'], ['C23.550.291.656'], ['D12.776.124.050.300', 'D12.776.124.790.106.394', 'D12.776.377.715.085.394', 'D12.776.395.560.373'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.998.650'... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Modelling the response of auditory midbrain neurons in the grassfrog to temporally structured monaural stimuli. | In a previous paper [Van Stokkum and Gielen, Hear. Res. 41, 71-86, 1989] a model was presented to describe the processing of monaural stimuli by the auditory periphery of the grassfrog. The main components of this model were: a middle ear filter, transduction and tuning of the haircell, short-term adaptation, action po... | ['Acoustic Stimulation', 'Animals', 'Auditory Pathways', 'Mesencephalon', 'Models, Neurological', 'Rana temporaria', 'Time Factors'] | 2,312,415 | [['E02.037', 'E02.190.888.030', 'E05.723.136'], ['B01.050'], ['A08.612.220.110'], ['A08.186.211.132.659'], ['E05.599.395.642'], ['B01.050.150.900.090.180.708.420'], ['G01.910.857']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Tissue and site-specific methylation correlates with expression of the mouse lactoferrin gene. | We have previously examined the regulatory region of the mouse lactoferrin gene and have identified sequences essential for basal and hormonally induced expression. In this study, we explore the relationship between the methylation state of the mouse lactoferrin gene promoter and its expression in selected mouse tissue... | ['Animals', 'Brain', 'Chloramphenicol O-Acetyltransferase', 'DNA', 'DNA-Cytosine Methylases', 'Deoxyribonuclease HpaII', 'Diethylstilbestrol', 'Estrogens, Non-Steroidal', 'Female', 'Gene Expression', 'Humans', 'Kidney', 'Lactoferrin', 'Liver', 'Lung', 'Methylation', 'Mice', 'Promoter Regions, Genetic', 'Recombinant Fus... | 10,425,446 | [['B01.050'], ['A08.186.211'], ['D08.811.913.050.134.170'], ['D13.444.308'], ['D08.811.913.555.500.350.100'], ['D08.811.150.280.260.420', 'D08.811.277.352.335.350.300.260.300', 'D08.811.277.352.355.325.300.260.300'], ['D02.455.426.559.389.150.700.725.500'], ['D27.505.696.399.472.277.540'], ['G05.297'], ['B01.050.150.90... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
RNAplex: a fast tool for RNA-RNA interaction search. | MOTIVATION: Regulatory RNAs often unfold their action via RNA-RNA interaction. Transcriptional gene silencing by means of siRNAs and miRNA as well as snoRNA directed RNA editing rely on this mechanism. Additionally ncRNA regulation in bacteria is mainly based upon RNA duplex formation. Finding putative target sites for... | ['Binding Sites', 'Computational Biology', 'Humans', 'RNA', 'Sensitivity and Specificity', 'Software', 'Time Factors'] | 18,434,344 | [['G02.111.570.120'], ['H01.158.273.180', 'L01.313.124'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D13.444.735'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700', 'N05.715.360.750.725', 'N06.850.520.445.800', 'N06.850.520.830.872'], ['L01.224.900'], ['G01.910.857']] | ['Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Cloning of urease gene sequences from Providencia stuartii. | Providencia stuartii was the most prevalent isolate recovered from urine specimens taken weekly over a 1-year period from 51 nursing home patients with urinary catheters in place. Thirty percent of the isolates were urease positive. Urease, which is implicated in renal stone formation, was shown to be transmissible on ... | ['Cell Compartmentation', 'Chromatography, Gel', 'Cloning, Molecular', 'Electrophoresis, Polyacrylamide Gel', 'Enzyme Induction', 'Genes, Bacterial', 'Kinetics', 'Macromolecular Substances', 'Molecular Weight', 'Mutation', 'Plasmids', 'Proteus', 'Providencia', 'Urease'] | 3,759,233 | [['G04.128'], ['E05.196.181.400.250'], ['E05.393.220'], ['E05.196.401.402', 'E05.301.300.319'], ['G05.308.320.200'], ['G05.360.340.024.340.364.249', 'G05.360.340.358.024.249', 'G05.360.340.358.207.249'], ['G01.374.661', 'G02.111.490'], ['D05'], ['G02.494'], ['G05.365.590'], ['G05.360.600'], ['B03.440.450.425.600', 'B03... | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Social media and drug resistance in nursing training: Using a Twitterchat to develop an international community of practice for antimicrobial resistance. | AIMS AND OBJECTIVES: To assess the impact of a Twitterchat focusing on antimicrobial resistance and it is feasibility for integration within a nursing prelicensure research methods class.BACKGROUND: Antimicrobial resistance is one of the greatest threats to global health and food security. Consequently, developing a gl... | ['Drug Resistance, Bacterial', 'Global Health', 'Humans', 'Information Dissemination', 'Social Media', 'Students, Nursing'] | 31,944,460 | [['G06.099.225', 'G06.225.347', 'G07.690.773.984.269.347'], ['H02.403.371', 'N01.400.337'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.143.443'], ['L01.178.751', 'L01.224.230.110.500.750'], ['M01.848.769.685']] | ['Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Organisms [B]', 'Information Science [L]', 'Named Groups [M]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 |
Caspase-8: a key role in the pathogenesis of diabetic embryopathy. | Maternal diabetes causes neural tube defects in embryos, which are associated with increased apoptosis in the neuroepithelium. Many factors, including effector caspases, have been shown to be involved in the events. However, the key regulators have not been identified and the underlying mechanisms remain to be addresse... | ['Abnormalities, Drug-Induced', 'Animals', 'Apoptosis', 'BH3 Interacting Domain Death Agonist Protein', 'Caspase 3', 'Caspase 8', 'Caspase 9', 'Diabetes Mellitus, Experimental', 'Disease Models, Animal', 'Dose-Response Relationship, Drug', 'Female', 'Fluorescent Antibody Technique, Indirect', 'Glucose', 'Image Processi... | 19,194,987 | [['C16.131.042'], ['B01.050'], ['G04.146.954.035'], ['D12.644.360.075.718.968', 'D12.776.476.075.718.937'], ['D08.811.277.656.262.500.126.350.300', 'D08.811.277.656.300.200.126.350.300', 'D12.644.360.075.405.350.300', 'D12.776.476.075.405.350.300'], ['D08.811.277.656.262.500.126.550.800', 'D08.811.277.656.300.200.126.5... | ['Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Radiological findings when very small lung volumes are irradiated in breast and chest wall treatment. | Acute pneumonitis following breast irradiation is a rare and transient phenomenon that can be easily managed by drugs. The aim of this study is to evaluate late sequelae on lung, after postoperative radiotherapy (RT) for breast cancer. We were concerned with investigating late radiological findings when very small lung... | ['Adult', 'Aged', 'Breast Neoplasms', 'Female', 'Humans', 'Lung', 'Middle Aged', 'Radiation Dosage', 'Radiation Pneumonitis', 'Radiotherapy', 'Thoracic Neoplasms', 'Tomography, X-Ray Computed'] | 9,503,490 | [['M01.060.116'], ['M01.060.116.100'], ['C04.588.180', 'C17.800.090.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A04.411'], ['M01.060.116.630'], ['E05.799.513', 'G01.750.740', 'N06.850.810.250'], ['C08.381.483.675', 'C08.381.520.734', 'C26.733.762', 'G01.750.748.500.762'], ['E02.815'], ['C04.588.894'], ['E... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
MicroRNA-137 is negatively associated with clinical outcome and regulates tumor development through EZH2 in cervical cancer. | We intend to evaluate the expression, clinical relevance, and functional role of microRNA-137 (miR-137) in human cervical cancer (CC). MiR-137 expressions were assessed by qPCR in CC cell lines and human CC tumors. The correlation between endogenous miR-137 expression and CC patients' postoperative overall survival was... | ["3' Untranslated Regions", 'Animals', 'Cell Line, Tumor', 'Cell Movement', 'Cell Proliferation', 'Disease-Free Survival', 'Enhancer of Zeste Homolog 2 Protein', 'Female', 'Gene Expression Regulation, Neoplastic', 'HeLa Cells', 'Humans', 'Mice', 'MicroRNAs', 'Neoplasm Transplantation', 'Prognosis', 'Uterine Cervical Ne... | 28,681,918 | [['D13.444.735.544.875.880', 'D13.444.735.790.878.880', 'G05.360.340.024.220.880.880', 'G05.360.340.024.340.137.910.880'], ['B01.050'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.198', 'G07.568.500.180'], ['G04.161.750', 'G07.345.249.410.750'], ['E01.789.800.190', 'E05.318.740.998.300', 'N04.761.559.590.800.190', 'N... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Pulmonary gas exchange during exercise in women: effects of exercise type and work increment. | Exercise-induced arterial hypoxemia (EIAH) has been reported in male athletes, particularly during fast-increment treadmill exercise protocols. Recent reports suggest a higher incidence in women. We hypothesized that 1-min incremental (fast) running (R) protocols would result in a lower arterial PO(2) (Pa(O(2))) than 5... | ['Adult', 'Blood Gas Analysis', 'Carbon Dioxide', 'Cardiac Output', 'Exercise', 'Exercise Test', 'Female', 'Humans', 'Hypoxia', 'Male', 'Oxygen', 'Oxygen Consumption', 'Pulmonary Gas Exchange', 'Respiratory Function Tests', 'Running'] | 10,926,659 | [['M01.060.116'], ['E01.370.225.124.100.100', 'E01.370.386.700.100', 'E05.200.124.100.100'], ['D01.200.200', 'D01.362.150', 'D01.650.550.200'], ['E01.370.370.380.150', 'G09.330.380.124'], ['G11.427.410.698.277', 'I03.350'], ['E01.370.370.380.250', 'E01.370.386.700.250', 'E05.333.250'], ['B01.050.150.900.649.313.988.400... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Interleukin-2 stimulates resting human T lymphocytes' response to allogeneic, gamma interferon-treated keratinocytes. | In order to investigate the biologic significance of HLA-DR expression by human keratinocytes, we have examined the possibility that DR-positive keratinocytes become alloantigen presenting cells for resting T cells in the presence of interleukin-2. Using this system, gamma interferon-treated, DR-positive keratinocytes ... | ['Antibodies, Monoclonal', 'Cells, Cultured', 'Epidermal Cells', 'Epidermis', 'HLA-D Antigens', 'HLA-DR Antigens', 'Humans', 'Interferon-gamma', 'Interleukin-2', 'Isoantibodies', 'Lymphocyte Activation', 'Recombinant Proteins', 'Stimulation, Chemical', 'T-Lymphocytes'] | 3,117,903 | [['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['A11.251'], ['A11.409'], ['A10.272.497', 'A17.815.250'], ['D12.776.395.550.509.400', 'D12.776.543.550.440.400', 'D23.050.301.500.400.400', 'D23.050.301.500.450.400', 'D23.050.705.552.410.400', 'D23.050.705.552.450.400'], ['... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Evidence for differential folding of farnesyl pyrophosphate in the active site of aristolochene synthase: a single-point mutation converts aristolochene synthase into an (E)-beta-farnesene synthase. | Sesquiterpene cyclases, many of which share significant structural similarity, catalyze the cyclization reactions of the universal alicyclic precursor farnesyl pyrophosphate to produce more than 300 different hydrocarbon skeletons with high regio- and stereospecificity. The molecular basis of this exquisite specificity... | ['Circular Dichroism', 'Isomerases', 'Penicillium', 'Point Mutation', 'Polyisoprenyl Phosphates', 'Sesquiterpenes', 'Structure-Activity Relationship'] | 12,820,883 | [['E05.196.867.151'], ['D08.811.399'], ['B01.300.381.662'], ['G05.365.590.675'], ['D02.455.849.690', 'D02.705.400.725'], ['D02.455.849.765'], ['G02.111.830', 'G07.690.773.997']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Agonist-stimulated Cl- efflux from human neutrophils. A common phenomenon during neutrophil activation. | When human peripheral blood neutrophils were stimulated with various agonists which activate and/or prime neutrophils, we found that Cl- efflux was enhanced with a dramatic (50%) loss of intracellular Cl-. Interestingly, the Cl- efflux was enhanced by both agonists which induce a rapid transient increase in intracellul... | ['Biological Transport', 'Calcium', 'Cell Size', 'Chlorides', 'Complement C5a', 'Dose-Response Relationship, Drug', 'Humans', 'Hydrogen-Ion Concentration', 'Interleukin-8', 'Lipopolysaccharides', 'N-Formylmethionine Leucyl-Phenylalanine', 'Neutrophils', 'Tumor Necrosis Factor-alpha'] | 8,494,532 | [['G03.143'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['G04.325'], ['D01.210.450.150', 'D01.248.497.158.215'], ['D12.776.124.486.274.024.270', 'D12.776.124.486.274.450.250'], ['G07.690.773.875', 'G07.690.936.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.300'], ['D12.644.276.374.200.120.80... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Association of reduced immunohistochemical expression of E-cadherin with a poor ovarian cancer prognosis--results of a meta-analysis. | PURPOSE: E-cadherin is a transmemberane protein which is responsible for adhesion of endothelial cells. The aim of our study was to assess existing evidence of associations between reduced expression of E-cadherin and prognosis of ovarian cancer with a discussion of potential approaches to exploiting any prognostic val... | ['Biomarkers, Tumor', 'Cadherins', 'Female', 'Humans', 'Immunoenzyme Techniques', 'Ovarian Neoplasms', 'Prognosis', 'Survival Rate'] | 22,901,162 | [['D23.101.140'], ['D12.776.395.550.200.200', 'D12.776.543.550.200.200', 'D23.050.301.350.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.478.566.350', 'E05.478.583.400', 'E05.601.470.350'], ['C04.588.322.455', 'C13.351.500.056.630.705', 'C13.351.937.418.685', 'C19.344.410', 'C19.391.630.705'], ['E01.789'... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Organophilic worm-like ruthenium nanoparticles catalysts by the modification of CTAB on montmorillonite supports. | A supported Ru catalyst was prepared by using cetyltrimethylammonium bromide (CTAB) intercalated montmorillonite as the supporting matrix. The as-prepared Ru catalyst was subsequently characterized by XRD, XPS, N(2) sorption, TEM, and dispersibility measurement. The results showed that the Ru nanoparticles were in the ... | ['Bentonite', 'Catalysis', 'Cetrimonium', 'Cetrimonium Compounds', 'Hydrogenation', 'Metal Nanoparticles', 'Particle Size', 'Quinolines', 'Ruthenium', 'Surface Properties'] | 23,141,762 | [['D01.056.050.075.100', 'D01.578.725.025.100', 'D01.650.550.050.075.100', 'D01.837.725.700.760.050.100'], ['G02.130'], ['D02.092.877.883.111.500', 'D02.675.276.190.500'], ['D02.092.877.883.111', 'D02.675.276.190'], ['G02.111.380', 'G02.607.324', 'G03.409'], ['J01.637.512.600.500'], ['G02.712'], ['D03.633.100.810'], ['... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Surgery for gastrointestinal stromal tumors of the duodenum. | BACKGROUND: Duodenal gastrointestinal stromal tumors (GISTs) represent a unique dilemma with varied surgical treatment options. However, the impact of operative methods on disease recurrence has never been addressed.METHODS: We retrospectively reviewed the medical records of all patients with duodenal GISTs treated at ... | ['Adult', 'Aged', 'Duodenal Neoplasms', 'Female', 'Follow-Up Studies', 'Gastrointestinal Stromal Tumors', 'Humans', 'Male', 'Medical Records', 'Middle Aged', 'Neoplasm Recurrence, Local', 'Pancreaticoduodenectomy', 'Prognosis', 'Retrospective Studies', 'Survival Rate', 'Treatment Outcome'] | 19,841,981 | [['M01.060.116'], ['M01.060.116.100'], ['C04.588.274.476.411.445', 'C06.301.371.411.445', 'C06.405.249.411.445', 'C06.405.469.275.270', 'C06.405.469.491.445'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['C04.557.450.565.370', 'C06.301.371.308', 'C06.405.249.308'], ['B01.... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Improved multiplex immunoassay performance in human plasma and synovial fluid following removal of interfering heterophilic antibodies. | Cytokines, chemokines and soluble adhesion molecules interact in a complex network within the immune system. Fingerprinting of these proteins may allow the use of these proteins as biomarkers for identification of disease, disease subtyping and monitoring therapeutic interventions. We developed a multiplex immunoassay ... | ['Antibodies, Heterophile', 'Arthritis, Rheumatoid', 'Autoantibodies', 'Blood Proteins', 'Case-Control Studies', 'Chemokines', 'Cytokines', 'Enzyme-Linked Immunosorbent Assay', 'Humans', 'Immunoassay', 'Osteoarthritis', 'Synovial Fluid'] | 15,896,801 | [['D12.776.124.486.485.114.191', 'D12.776.124.790.651.114.191', 'D12.776.377.715.548.114.191'], ['C05.550.114.154', 'C05.799.114', 'C17.300.775.099', 'C20.111.199'], ['D12.776.124.486.485.114.323', 'D12.776.124.790.651.114.323', 'D12.776.377.715.548.114.323'], ['D12.776.124'], ['E05.318.372.500.500', 'N05.715.360.330.5... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Challenges in bringing exempt psychiatric services under a prospective payment system. | By December 31, 1985, the Secretary of the Department of Health and Human Services must report to Congress on whether psychiatric programs now exempt from Medicare's prospective payment system can be brought under that system, and if so, how. The underlying issue is determining how funds for psychiatric treatment shoul... | ['Costs and Cost Analysis', 'Diagnosis-Related Groups', 'Evaluation Studies as Topic', 'Health Services Research', 'Hospitals, Psychiatric', 'Humans', 'Length of Stay', 'Medicare', 'Mental Disorders', 'Mental Health Services', 'Prospective Payment System', 'Psychiatric Department, Hospital', 'Reimbursement Mechanisms',... | 3,926,623 | [['N03.219.151'], ['N03.219.521.710.305.200.080'], ['E05.337', 'N05.715.360.335'], ['H01.770.644.145.360', 'N03.349.380', 'N05.425'], ['N02.278.421.556.508'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.760.400.480', 'N02.421.585.400.480'], ['N03.219.521.346.506.564.663', 'N03.219.521.576.343.840', 'N03.706.... | ['Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 |
A novel human surrogate model of noninjurious sharp mechanical pain. | We propose a blade as a noninjurious nociceptive stimulus modeling sharp mechanical pain and yielding acute pain and hyperalgesia responses with closer proximity to incision-induced pain/hyperalgesia than punctate or blunt pressure mechanical pain models. Twenty-six healthy men and women were investigated to compare a ... | ['Adolescent', 'Adult', 'Female', 'Humans', 'Hyperalgesia', 'Male', 'Pain Measurement', 'Pain Threshold', 'Physical Stimulation', 'Young Adult'] | 26,397,930 | [['M01.060.057'], ['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.597.751.791.400', 'C23.888.592.763.770.400'], ['E01.370.600.550.324'], ['F02.463.593.710.560', 'F02.830.816.444.700', 'G11.561.790.444.700'], ['E05.723'], ['M01.060.116.815']] | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Neuropeptides in the gastrointestinal canal of Necturus maculosus. Distribution and effects on motility. | The presence and distribution of regulatory peptides in nerves and endocrine cells of the stomach, intestine and rectum of a urodele amphibian, the mudpuppy, Necturus maculosus, was studied immunohistochemically in sections or whole-mount preparations of the gut wall. The effect of the occurring peptides on gut motilit... | ['Animals', 'Bombesin', 'Cholecystokinin', 'Digestive System', 'Digestive System Physiological Phenomena', 'Enkephalin, Methionine', 'Fluorescent Antibody Technique', 'Gastrins', 'Gastrointestinal Motility', 'Immune Sera', 'Microscopy, Electron', 'Necturus', 'Nerve Tissue Proteins', 'Neurotensin', 'Somatostatin', 'Subs... | 2,411,414 | [['B01.050'], ['D06.472.699.100', 'D12.644.400.085', 'D12.644.548.100', 'D12.776.631.650.085', 'D20.888.033.137', 'D23.946.833.033.137'], ['D06.472.317.152', 'D12.644.120'], ['A03'], ['G10.261'], ['D12.644.400.575.281.381', 'D12.776.631.650.575.281.381'], ['E01.370.225.500.607.512.240', 'E01.370.225.750.551.512.240', '... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Choriocarcinoma cells increase the number of differentiating human cytotrophoblasts through an in vitro interaction. | The human placenta arises from the zygote through single cell intermediates called cytotrophoblasts that in turn give rise to a syncytium. In culture, mononucleated cytotrophoblasts exhibit little, if any, cell division but are converted to multinucleated cells. Choriocarcinoma, the malignant tumor of placenta trophobl... | ['Animals', 'Cell Communication', 'Cell Differentiation', 'Cell Line', 'Choriocarcinoma', 'Cricetinae', 'Female', 'HeLa Cells', 'Humans', 'Kinetics', 'Ovary', 'Placenta', 'Placental Hormones', 'Trophoblasts', 'Tumor Cells, Cultured', 'Uterine Neoplasms'] | 2,022,665 | [['B01.050'], ['G04.085'], ['G04.152'], ['A11.251.210'], ['C04.557.465.955.207', 'C04.557.470.200.025.455', 'C04.850.908.208', 'C13.703.720.949.208'], ['B01.050.150.900.649.313.992.635.075.250'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.374.66... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Antibiotic use in five children's hospitals during 2002-2006: the impact of antibiotic guidelines issued by the Chinese Ministry of Health. | PURPOSE: To investigate the pattern of antibiotic use in five Chinese children's hospitals from 2002 to 2006. To see if the Guidelines to encourage rational use of antibiotics issued by the Ministry of Health in October 2004 have any impact on the use.METHODS: The Anatomical Therapeutic Chemical Classification/Defined ... | ['Adolescent', 'Anti-Bacterial Agents', 'Cephalosporins', 'Child', 'Child, Preschool', 'China', 'Databases, Factual', 'Drug Utilization', 'Female', 'Guideline Adherence', 'Hospitals, Pediatric', 'Humans', 'Infant', 'Male', 'Practice Guidelines as Topic', "Practice Patterns, Physicians'", 'Retrospective Studies'] | 18,165,944 | [['M01.060.057'], ['D27.505.954.122.085'], ['D02.065.589.099.249', 'D02.886.665.074', 'D03.633.100.300.249'], ['M01.060.406'], ['M01.060.406.448'], ['Z01.252.474.164'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['N04.452.706.477'], ['N04.761.337', 'N05.715.360.395'], ['N02.278.421.556.437'], ['B01.050.150.900... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Information Science [L]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
A note on the impact of hours worked on mortality in OECD countries. | We investigate whether an increase in hours worked per employed person raises the total mortality rate in a sample of 23 OECD countries. We build on earlier research but extend the analysis by introducing the number of hours worked per employed as an additional regressor. Contrary to our expectations, we found that an ... | ['Female', 'Humans', 'Male', 'Models, Statistical', 'Mortality', 'Risk Factors', 'Work Schedule Tolerance'] | 15,452,736 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500', 'E05.599.835', 'N05.715.360.750.530', 'N06.850.520.830.500'], ['E05.318.308.985.550', 'N01.224.935.698', 'N06.850.505.400.975.550', 'N06.850.520.308.985.550'], ['E05.318.740.600.800.725', 'N05.715.350.200.700', 'N05.715.360.750.625.700.700', 'N06.850... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Clinical significance of osmotic matrix errors in automated hematology: the frequency of hyperglycemic osmotic matrix errors producing spurious macrocytosis. | Sporadic examples of spurious macrocytosis due to hyperglycemic osmotic matrix effects have been reported. The present study defines the degree of macrocytosis expected under hyperglycemic normonatremic conditions using a Coulter S + II Isoton + System and its frequency in a large inpatient and outpatient population. N... | ['Erythrocyte Indices', 'Glucose', 'Humans', 'Hyperglycemia', 'Methods', 'Osmosis', 'Osmotic Fragility', 'Prospective Studies'] | 6,637,892 | [['E01.370.225.625.230', 'E05.200.625.230', 'G09.188.260'], ['D09.947.875.359.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C18.452.394.952'], ['E05.581'], ['G01.154.090.750', 'G02.111.655', 'G02.691', 'G02.723.495'], ['E01.370.225.625.550', 'E05.200.625.550', 'G09.188.640'], ['E05.318.372.500.750.625', 'N0... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Evidence of Self-Sustaining Drug Resistant HIV-1 Lineages Among Untreated Patients in the United Kingdom. | BACKGROUND: About 10% of new diagnoses of subtype B human immunodeficiency virus type 1 (HIV-1) in the United Kingdom are with viruses showing transmitted drug resistance (TDR). However, there is discordance between the mutation patterns observed in HIV-infected patients failing therapy and those seen in TDR.METHODS: W... | ['Drug Resistance, Viral', 'Female', 'HIV Infections', 'HIV-1', 'Humans', 'Male', 'Models, Statistical', 'Phylogeny', 'United Kingdom'] | 25,991,470 | [['G06.225.420', 'G06.920.225', 'G07.690.773.984.269.420'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['B04.820.650.589.650.350.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500', 'E05.599.835', 'N05.715.360.750.53... | ['Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Information Science [L]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 |
The relative timing of trunk muscle activation is retained in response to unanticipated postural-perturbations during acute low back pain. | The purpose of this study was to assess the activation of the erector spinae (ES) and external oblique (EO) in response to unanticipated, bi-directional postural perturbations before and after the induction of acute low back pain (LBP) in healthy individuals. An experimental session consisted of a baseline, control, an... | ['Acute Disease', 'Adaptation, Physiological', 'Female', 'Humans', 'Low Back Pain', 'Male', 'Muscle Contraction', 'Muscle, Skeletal', 'Postural Balance', 'Reaction Time', 'Reflex', 'Time Factors', 'Young Adult'] | 21,442,223 | [['C23.550.291.125'], ['G07.025', 'G16.012.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.888.592.612.107.400'], ['G11.427.494'], ['A02.633.567', 'A10.690.552.500'], ['F02.830.816.541.752', 'G07.888.750.500', 'G11.427.690', 'G11.561.790.541.595'], ['E05.796.817', 'F02.830.650', 'F04.669.817', 'G11.561.67... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Highly sensitive reaction of tryptophan with p-phenylenediamine. | A simple and sensitive spectrophotometric method for the determination of tryptophan (TRP) is described. The method is based on the coupling reaction of tryptophan with diazotized p-phenylenediamine dihydrochloride (PPDD) in sulfuric acid medium to give the colored product having an absorption maximum at 520 nm. The co... | ['Molecular Structure', 'Phenylenediamines', 'Proteins', 'Reproducibility of Results', 'Sensitivity and Specificity', 'Spectrophotometry', 'Tablets', 'Tryptophan'] | 12,531,200 | [['G02.111.570', 'G02.466'], ['D02.092.146.651', 'D02.092.782.258.651'], ['D12.776'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700', 'N05.715.360.750.725', 'N06.850.520.445.800', 'N06.850.520.830.872'], ['E05.196... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Fluorescence polarization studies on Escherichia coli membrane stability and its relation to the resistance of the cell to freeze-thawing. II. Stabilization of the membranes by polyamines. | The effects of polyamines, spermine, spermidine and putrescine on the stabilization of the membrane organization of Escherichia coli cells were studied using measurements of fluorescence polarization change of extrinsic fluorescence probes in membrane specimens as a function of temperature. The effects of the polyamine... | ['Cell Membrane', 'Escherichia coli', 'Fluorescence Polarization', 'Freezing', 'Membrane Fluidity', 'Membrane Lipids', 'Phospholipids', 'Polyamines'] | 3,530,328 | [['A11.284.149'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['E05.196.712.516.600.390'], ['G01.645.500', 'G01.906.595.272.437', 'G02.734.466'], ['G01.154.500', 'G02.111.550', 'G04.570'], ['D10.570'], ['D10.570.755'], ['D02.092.782']] | ['Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Device for measuring the acoustic impedance of the middle ear]. | There exists a direct proportional relation between the acoustic impedance of the tympanic membrane and static pressure in the external acoustic duct. This relation forms the basis of the UM-01 device which enables the acoustic impedance to be determined and allows it to judge from its magnitude on the condition of the... | ['Acoustics', 'Ear, Middle', 'Electronics, Medical', 'Hearing Tests', 'USSR'] | 1,214,573 | [['H01.671.031'], ['A09.246.397'], ['H01.671.293.319'], ['E01.370.382.375'], ['Z01.542.931', 'Z01.586.950']] | ['Disciplines and Occupations [H]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 |
Dietary nitrate supplementation improves sprint and high-intensity intermittent running performance. | The influence of dietary nitrate (NO3-) supplementation on indices of maximal sprint and intermittent exercise performance is unclear.PURPOSE: To investigate the effects of NO3- supplementation on sprint running performance, and cognitive function and exercise performance during the sport-specific Yo-Yo Intermittent Re... | ['Adult', 'Athletic Performance', 'Beta vulgaris', 'Blood Pressure', 'Cross-Over Studies', 'Dietary Supplements', 'Double-Blind Method', 'Fruit and Vegetable Juices', 'Humans', 'Male', 'Nitrates', 'Nitrites', 'Running', 'Stroop Test', 'Young Adult'] | 27,777,094 | [['M01.060.116'], ['I03.450.642.845.054'], ['B01.650.940.800.575.912.250.200.399'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E05.318.370.150', 'N05.715.360.325.150', 'N06.850.520.445.150'], ['G07.203.300.456', 'J02.500.456'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['G... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]', 'Psychiatry and Psycholo... | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 |
Three-dimensional structure of an Fab-peptide complex: structural basis of HIV-1 protease inhibition by a monoclonal antibody. | F11.2.32, a monoclonal antibody raised against HIV-1 protease (Kd = 5 nM), which inhibits proteolytic activity of the enzyme (K(inh) = 35(+/-3)nM), has been studied by crystallographic methods. The three-dimensional structure of the complex between the Fab fragment and a synthetic peptide, spanning residues 36 to 46 of... | ['Amino Acid Sequence', 'Antibodies, Monoclonal', 'Base Sequence', 'Binding Sites', 'Cloning, Molecular', 'Computer Simulation', 'Cross Reactions', 'Crystallography, X-Ray', 'HIV Protease', 'HIV Protease Inhibitors', 'Hybridomas', 'Immunoglobulin Fab Fragments', 'Models, Molecular', 'Molecular Sequence Data', 'Sequence... | 9,150,407 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G02.111.570.120'], ['E05.393.220'], ['L01.224.160'], ['G12.122.281'], ['E05.196.309.742.225'], ['D08.811.277.656.074.50... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
The International Dermatology Outcome Measures Group: formation of patient-centered outcome measures in dermatology. | As quality standards are increasingly in demand throughout medicine, dermatology needs to establish outcome measures to quantify the effectiveness of treatments and providers. The International Dermatology Outcome Measures Group was established to address this need. Beginning with psoriasis, the group aims to create a ... | ['Arthritis, Psoriatic', 'Dermatology', 'Forecasting', 'Foundations', 'Humans', 'Internationality', 'Outcome Assessment, Health Care', 'Patient Outcome Assessment', 'Patient-Centered Care', 'Psoriasis', 'Quality of Life', 'Rheumatology', 'Severity of Illness Index'] | 25,486,914 | [['C05.116.900.853.625.800.424', 'C05.550.114.145', 'C05.550.114.865.800.424', 'C17.800.859.675.175'], ['H02.403.225'], ['I01.320'], ['N03.219.483.311', 'N03.540.630.180'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I01.615'], ['H01.770.644.145.431', 'N04.761.559.590', 'N05.715.360.575.575'], ['N04.761.559.590.... | ['Diseases [C]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Humanities [K]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 |
Recovering from mental health problems: perceived positive and negative effects of medication on reconnecting with life. | BACKGROUND: At present there is no coherent theory of mental health recovery capable of guiding clinical practice.MATERIALS: On the basis of 32 interviews with those recovering in Ireland, a grounded theory study generated a theory of recovery as reconnecting with life. This paper reports extended findings on the perce... | ['Adult', 'Aged', 'Female', 'Humans', 'Interpersonal Relations', 'Interviews as Topic', 'Ireland', 'Male', 'Mental Disorders', 'Middle Aged', 'Models, Theoretical', 'Psychotropic Drugs'] | 20,659,964 | [['M01.060.116'], ['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.401'], ['E05.318.308.420', 'L01.399.250.520', 'N05.715.360.300.400', 'N06.850.520.308.420'], ['Z01.542.467', 'Z01.639.587'], ['F03'], ['M01.060.116.630'], ['E05.599'], ['D27.505.954.427.700']] | ['Named Groups [M]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]', 'Geographicals [Z]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
Pain relief in medical patients: does clinical judgment and prescribing knowledge suffice? | The aim of this study was to evaluate the quality of pain management in hospitalised patients. A cross-sectional study design that included all medical patients experiencing pain was used. Out of 167 patients hospitalized at the Department of Medicine at the University Hospital Zagreb, 41 patients were experiencing pai... | ['Adult', 'Analgesia', 'Analgesics', 'Clinical Competence', 'Cross-Sectional Studies', 'Female', 'Humans', 'Male', 'Middle Aged', 'Pain', 'Pain Measurement', 'Patient Satisfaction', 'Physicians'] | 21,755,704 | [['M01.060.116'], ['E03.091'], ['D27.505.696.663.850.014', 'D27.505.954.427.040'], ['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C23.888.592.612', 'F02.830.816.444'... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Outperforming whom? A multilevel study of performance-prove goal orientation, performance, and the moderating role of shared team identification. | Performance-prove goal orientation affects performance because it drives people to try to outperform others. A proper understanding of the performance-motivating potential of performance-prove goal orientation requires, however, that we consider the question of whom people desire to outperform. In a multilevel analysis... | ['Adult', 'Cooperative Behavior', 'Female', 'Goals', 'Group Processes', 'Humans', 'Male', 'Social Identification', 'Work Performance'] | 26,011,723 | [['M01.060.116'], ['F01.145.813.115'], ['F01.658.500'], ['F01.829.316'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.813.708'], ['I03.946.675']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Determination of adefovir in human plasma by liquid chromatography/tandem mass spectrometry: application to a pharmacokinetic study. | A liquid chromatography/tandem mass spectrometry (LC/MS/MS) method was developed and validated to determine the concentrations of adefovir [9-(2-phosphonylmethoxyethyl)adenine, PMEA] in human plasma. After one-step protein precipitation of plasma samples by methanol, adefovir was analyzed by LC/MS/MS using positive ele... | ['Adenine', 'Administration, Oral', 'Adult', 'Blood Chemical Analysis', 'Chromatography, High Pressure Liquid', 'Dose-Response Relationship, Drug', 'Drug Evaluation', 'Female', 'Humans', 'Male', 'Metabolic Clearance Rate', 'Organophosphonates', 'Pharmacokinetics', 'Reproducibility of Results', 'Sensitivity and Specific... | 16,167,376 | [['D03.633.100.759.138'], ['E02.319.267.100'], ['M01.060.116'], ['E01.370.225.124.100', 'E05.200.124.100'], ['E05.196.181.400.300'], ['G07.690.773.875', 'G07.690.936.500'], ['E05.290.625', 'E05.337.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.843', 'E05.200.843', 'G03.490', 'G07.690.595', 'G07.... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Microscopic innervation of the spermatic ducts and testis. I. Vas deferens]. | The microscopic innervation of the vas deferens in the rat was studied both in light and electron microscope. The nerve fibres form perivascular, intramuscular and subepithelial plexuses. Inside the connective tissue surrounding the vas deferens both isolated nerve fibres and sensory corpuscles (glomerular and Ruffine-... | ['Adrenergic Fibers', 'Animals', 'Cholinergic Fibers', 'Connective Tissue', 'Male', 'Muscle, Smooth', 'Nerve Endings', 'Rats', 'Rats, Inbred Strains', 'Vas Deferens'] | 2,817,980 | [['A08.675.100.500', 'A08.675.542.075', 'A11.671.501.075'], ['B01.050'], ['A08.675.127.500', 'A08.675.542.234', 'A11.671.188.500', 'A11.671.501.234'], ['A10.165'], ['A02.633.570', 'A10.690.467'], ['A08.800.550'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760', 'B01.050.150.900.649.313.992.635.5... | ['Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Self-control as a predictor of relapse and recidivism in adolescent therapeutic community treatment. | Despite the effectiveness of Therapeutic Communities (TCs), empirical studies of TCs are mostly atheoretical. In this study, concepts related to Gottfredson and Hirschi's General Theory of Crime were used to predict posttreatment delinquency among adolescents. Using data collected as part of Drug Abuse Treatment Outcom... | ['Adolescent', 'Alcohol Drinking', 'Crime', 'Female', 'Humans', 'Juvenile Delinquency', 'Male', 'Program Evaluation', 'Psychological Theory', 'Secondary Prevention', 'Social Control, Informal', 'Substance-Related Disorders', 'Therapeutic Community'] | 23,181,932 | [['M01.060.057'], ['F01.145.317.269'], ['I01.198.240', 'I01.880.735.191'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I01.880.735.479'], ['E05.337.820', 'N04.761.685', 'N05.715.360.650'], ['F02.739'], ['E02.897', 'N02.421.726.825', 'N06.850.780.750'], ['I01.880.630'], ['C25.775', 'F03.900'], ['F04.754.864.392.7... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
[Differentiation of K562 cells induced by antisense oligonucleotide targeting survivin]. | OBJECTIVE: Gene therapy of leukemia is a new and effective method. It is known to all that the pathogenesis and development of leukemia are related to a variety of genes. Survivin is a member of inhibitors of apoptotic proteins (IAP). Its cDNA was cloned from target cell protease receptor-1 (EPR-1). It is expressed in ... | ['Antigens, CD', 'Antigens, Differentiation, Myelomonocytic', 'Cell Differentiation', 'Humans', 'Inhibitor of Apoptosis Proteins', 'K562 Cells', 'Microtubule-Associated Proteins', 'Oligonucleotides, Antisense', 'Sialic Acid Binding Ig-like Lectin 3', 'Survivin', 'Transfection'] | 15,924,721 | [['D23.050.301.264.035', 'D23.101.100.110'], ['D23.050.301.264.900', 'D23.101.100.900'], ['G04.152'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.464.938.750.210', 'D12.644.360.075.437', 'D12.776.476.075.437'], ['A11.251.210.190.510', 'A11.251.860.180.510', 'A11.443.240.497.480'], ['D12.776.220.600.450',... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Acetaminophen elimination kinetics in neonates, children, and adults. | The elimination of acetaminophen (APAP) following an oral dose of 10 mg/kg in newborn infants, children, and adults was compared. Urinary excretion of unchanged APAP, APAP-sulfate, and APAP-glucuronide was complete within 30 hr at all ages. Higher percentages of the dose were excreted in the urine as APAP-sulfate in ne... | ['Acetaminophen', 'Adult', 'Age Factors', 'Child', 'Child, Preschool', 'Female', 'Glucuronates', 'Half-Life', 'Humans', 'Infant', 'Infant, Newborn', 'Kinetics', 'Male', 'Models, Biological', 'Sulfates'] | 1,261,167 | [['D02.065.199.092.040', 'D02.092.146.113.092.040'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.406'], ['M01.060.406.448'], ['D02.241.081.844.915.162', 'D02.241.152.811.162', 'D02.241.511.902.915.162', 'D09.811.922.162'], ['G01.910.405'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.06... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Early rheological and microcirculatory changes in children with type I diabetes mellitus. | In order to determine early changes in microcirculation and hemorheological parameters in diabetics, a cross-sectional study was carried out with 273 children with diabetes mellitus type I during their vacation in a state country convalescent home for diabetic children and teenagers in Kaiserslautern. Compared to healt... | ['Adolescent', 'Blood Viscosity', 'Capillaries', 'Child', 'Diabetes Mellitus, Type 1', 'Diabetic Angiopathies', 'Erythrocyte Deformability', 'Hematocrit', 'Hemorheology', 'Humans', 'Microcirculation', 'Platelet Aggregation', 'Reference Values'] | 9,849,927 | [['M01.060.057'], ['G09.188.370.124', 'G09.330.380.630.110'], ['A07.015.461.165'], ['M01.060.406'], ['C18.452.394.750.124', 'C19.246.267', 'C20.111.327'], ['C14.907.320', 'C19.246.099.500'], ['G09.188.370.249'], ['E01.370.225.625.400', 'E05.200.625.400', 'G09.188.370.374'], ['E05.830.250', 'G09.188.370', 'G09.330.380.6... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Physicochemical properties of newly developed bioactive glass cement and its effects on various cells. | Biomaterials used in dental treatments are expected to have favorable properties such as biocompatibility and an ability to induce tissue formation in dental pulp and periapical tissue, as well as sealing to block external stimuli. Bioactive glasses have been applied in bone engineering, but rarely applied in the field... | ['Animals', 'Dental Cements', 'Glass', 'Humans', 'Materials Testing', 'Mice', 'PC12 Cells', 'Rats'] | 24,895,094 | [['B01.050'], ['D25.339.291', 'J01.637.051.339.291'], ['J01.637.437'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.570'], ['B01.050.150.900.649.313.992.635.505.500'], ['A11.251.210.190.750', 'A11.251.860.180.750', 'A11.299.500'], ['B01.050.150.900.649.313.992.635.505.700']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Coincidence of conchachoanal polyp and complete mulberry hypertrophy of inferior concha. | We report two unique cases of 50- and 28-year-old Turkish men with coincidence of conchachoanal polyp and mulberry hypertrophy of the inferior concha. We operated on both cases with endoscopic stripping of the polypoid tissue while preserving the periosteum and healthy mucosa of the inferior nasal concha. The polypoid ... | ['Adult', 'Humans', 'Hypertrophy', 'Male', 'Middle Aged', 'Nasal Obstruction', 'Nasal Polyps', 'Turbinates'] | 19,205,019 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.300.775'], ['M01.060.116.630'], ['C08.460.525', 'C08.618.846.185.525', 'C09.603.525'], ['C08.460.572', 'C09.603.557', 'C23.300.825.557'], ['A02.835.232.781.324.948', 'A04.531.898']] | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Descent of ova and embryos in cows superovulated with serum gonadotropin]. | The descent and localization of eggs and embryos in individual segments of the reproductive tract of superovulated cows were studied in this work. For the induction of superovulation, serum gonadotropin (PMSG, Ivanovice in Han?) at a dose of 2,500-3,500 I.U. was used, in combination with 0.5 mg of Cloprostenol (Oestrop... | ['Animals', 'Cattle', 'Embryo, Mammalian', 'Female', 'Gonadotropins, Equine', 'Ovum Transport', 'Superovulation'] | 1,413,397 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['A16.254'], ['D06.472.699.322.451', 'D06.472.699.649.451', 'D12.644.548.726.451', 'D12.776.780.451'], ['G04.198.700', 'G08.686.784.277.360'], ['E02.875.800.984.500', 'E05.820.800.984.500', 'G08.686.784.690.768']] | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Thyroid micro-carcinoma: only a diagnostic epidemic? | BACKGROUND: The incidence of thyroid carcinoma ranges from 0.5 to 10 cases every 100,000, depending on the country, the context and purpose of the study. The high incidence of differentiated thyroid tumor is continuously growing. While most malignant pathologies affect the adults, a proportion of 1-2% of pediatric popu... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Biopsy, Fine-Needle', 'Carcinoma', 'Epidemics', 'Female', 'Humans', 'Incidence', 'Italy', 'Male', 'Middle Aged', 'Predictive Value of Tests', 'Prospective Studies', 'Thyroid Neoplasms', 'Thyroidectomy', 'Ultrasonography, Doppler, Color', 'Young Adult'] | 27,589,679 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E01.370.225.500.384.100.119.500', 'E01.370.225.998.054.119.500', 'E01.370.388.100.100.500', 'E04.074.119.500', 'E04.665.100.500', 'E05.200.500.384.100.119.500', 'E05.200.998.054.119.500', 'E05.242.384.100.119.500'], ['C04.557.470.200'], ... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Cross talk between NO and cyclic nucleotide phosphodiesterases in the modulation of signal transduction in blood vessel. | An increase in cAMP and/or cGMP induces vasodilation which could be potentiated by endothelium or NO-donors. Cyclic nucleotide phosphodiesterases (PDE) are differently distributed in vascular tissues. cAMP hydrolyzing PDE isozymes in endothelial cells are represented by PDE2 (cGMP stimulated-PDE) and PDE4 (cGMP insensi... | ['Animals', 'Aorta', 'Cattle', 'Cells, Cultured', 'Cyclic AMP', 'Cyclic GMP', 'Dose-Response Relationship, Drug', 'Endothelium, Vascular', 'In Vitro Techniques', 'Nitric Oxide', 'Phosphodiesterase Inhibitors', 'Protein Kinases', 'Radioimmunoassay', 'Rats', 'Rats, Wistar', 'Recombinant Proteins', 'Signal Transduction', ... | 10,639,014 | [['B01.050'], ['A07.015.114.056'], ['B01.050.150.900.649.313.500.380.271'], ['A11.251'], ['D03.633.100.759.646.138.395', 'D13.695.462.200', 'D13.695.667.138.395', 'D13.695.827.068.395'], ['D03.633.100.759.646.454.160', 'D13.695.462.275', 'D13.695.667.454.160', 'D13.695.827.426.160'], ['G07.690.773.875', 'G07.690.936.50... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Transplantation rates for living- but not deceased-donor kidneys vary with socioeconomic status in Australia. | Socioeconomic disadvantage has been linked to reduced access to kidney transplantation. To understand and address potential barriers to transplantation, we used the Australia and New Zealand Dialysis and Transplant Registry and examined primary kidney-only transplantation among adult non-Indigenous patients who commenc... | ['Aged', 'Australia', 'Female', 'Health Services Accessibility', 'Humans', 'Kidney Failure, Chronic', 'Kidney Transplantation', 'Living Donors', 'Male', 'Middle Aged', 'Registries', 'Retrospective Studies', 'Sex Factors', 'Social Class', 'Tissue Donors', 'Tissue and Organ Procurement'] | 22,895,516 | [['M01.060.116.100'], ['Z01.639.100', 'Z01.678.100.373'], ['N04.590.374.350', 'N05.300.430'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.777.419.780.750.500', 'C13.351.968.419.780.750.500'], ['E02.870.500', 'E04.936.450.485', 'E04.950.774.400'], ['M01.898.656'], ['M01.060.116.630'], ['E05.318.308.970', 'N04... | ['Named Groups [M]', 'Geographicals [Z]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Growth inhibitory activity of cucurbitacin glucosides isolated from Citrullus colocynthis on human breast cancer cells. | Our aim was to study the effects of cucurbitacin glucosides extracted from Citrullus colocynthis leaves on human breast cancer cell growth. Leaves were extracted, resulting in the identification of cucurbitacin B/E glucosides. The cucurbitacin glucoside combination (1:1) inhibited growth of ER(+) MCF-7 and ER(-) MDA-MB... | ['Blotting, Western', 'Breast Neoplasms', 'Cell Cycle', 'Cell Division', 'Cell Line, Tumor', 'Citrullus', 'Flow Cytometry', 'Glucosides', 'Humans', 'Magnetic Resonance Spectroscopy', 'Membrane Potentials', 'Microscopy, Fluorescence'] | 17,049,494 | [['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['C04.588.180', 'C17.800.090.500'], ['G04.144'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.251.210.190', 'A11.251.860.180'], ['B01.650.940.800.575.912.250.300.140'], ['E01.370.225.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
An introduction to multiple time series analysis. | An expository account of multiple time series analysis is presented. Modeling several related time series together makes it possible to ascertain dynamic leading, lagging, and feedback relationships among the series; to produce more efficient forecasts and, in some situations; to develop control schemes. Procedures for... | ['Health Services Research', 'Linear Models', 'Normal Distribution', 'Smoke', 'Survival Analysis', 'Time Factors'] | 8,492,590 | [['H01.770.644.145.360', 'N03.349.380', 'N05.425'], ['E05.318.740.500.500', 'E05.318.740.750.425', 'E05.599.835.750', 'N05.715.360.750.530.460', 'N05.715.360.750.695.460', 'N06.850.520.830.500.500', 'N06.850.520.830.750.425'], ['E05.318.740.994.500', 'G17.820.500', 'N05.715.360.750.750.565', 'N06.850.520.830.994.500'],... | ['Disciplines and Occupations [H]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
A multicenter, randomized, double-blind study comparing famotidine with ranitidine in the treatment of active duodenal ulcer disease. | Famotidine, a new long-acting histamine (H2)-receptor antagonist, has recently been shown to be more effective than placebo in healing active duodenal ulcer. In the current study, the efficacy and tolerability of famotidine were further investigated and compared with those of ranitidine in a multicenter, double-blind, ... | ['Adolescent', 'Adult', 'Clinical Trials as Topic', 'Double-Blind Method', 'Drug Administration Schedule', 'Duodenal Ulcer', 'Famotidine', 'Female', 'Histamine H2 Antagonists', 'Humans', 'Male', 'Middle Aged', 'Random Allocation', 'Ranitidine', 'Thiazoles'] | 2,877,570 | [['M01.060.057'], ['M01.060.116'], ['E05.318.372.250.250', 'N05.715.360.330.250.250', 'N06.850.520.450.250.250'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['E02.319.283'], ['C06.405.469.275.800.348', 'C06.405.748.586.349'], ['D02.886.675.215', 'D03.383.129.708.215'], ['D27.5... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Fish sperm subpopulations: Changes after cryopreservation process and relationship with fertilization success in tambaqui (Colossoma macropomum). | Fish tambaqui (Colossoma macropomum) is the native Brazilian fish with the highest agricultural production under intensive aquaculture in South America. However, the decrease in the genetic variability in fish farms has become necessary the improvement of cryopreservation process through new statistical studies of sper... | ['Animals', 'Biomarkers', 'Cryopreservation', 'Female', 'Fertility', 'Fertilization', 'Fishes', 'Male', 'Ovum', 'Semen', 'Semen Preservation', 'Sperm Motility', 'Spermatozoa'] | 27,616,215 | [['B01.050'], ['D23.101'], ['E01.370.225.500.620.760.160', 'E01.370.225.750.600.760.160', 'E02.792.156', 'E05.200.500.620.760.160', 'E05.200.750.600.760.160', 'E05.760.156'], ['G08.686.210'], ['G08.686.784.277'], ['B01.050.150.900.493'], ['A05.360.490.690', 'A11.497.497', 'A16.690'], ['A12.200.732'], ['E02.792.833.890'... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Tyrannosaurus was not a fast runner. | The fastest gait and speed of the largest theropod (carnivorous) dinosaurs, such as Tyrannosaurus, is controversial. Some studies contend that Tyrannosaurus was limited to walking, or at best an 11 m s(-1) top speed, whereas others argue for at least 20 m s(-1) running speeds. We demonstrate a method of gauging running... | ['Alligators and Crocodiles', 'Animals', 'Biomechanical Phenomena', 'Chickens', 'Dinosaurs', 'Models, Anatomic', 'Muscle, Skeletal', 'Running', 'Walking'] | 11,875,567 | [['B01.050.150.900.833.100'], ['B01.050'], ['G01.154.090', 'G01.374.089'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['B01.050.150.900.833.150'], ['J01.897.280.500.545.129', 'L01.178.820.090.545.129'], ['A02.633.567', 'A10.690.552.500'], ['G11.427.410.568.610', 'G11.427.410.698.277.750', 'I03.350.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]', 'Anatomy [A]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 |
The first nutritionDay in nursing homes: participation may improve malnutrition awareness. | BACKGROUND & AIMS: A modified version of the nutritionDay project was developed for nursing homes (NHs) to increase malnutrition awareness in this area. This report aims to describe the first results from the NH setting.METHODS: On February 22, 2007, 8 Austrian and 30 German NHs with a total of 79 units and 2137 reside... | ['Aged, 80 and over', 'Aging', 'Austria', 'Body Mass Index', 'Cross-Sectional Studies', 'Feasibility Studies', 'Female', 'Follow-Up Studies', 'Geriatric Assessment', 'Germany', 'Health Knowledge, Attitudes, Practice', 'Health Promotion', 'Homes for the Aged', 'Humans', 'Male', 'Malnutrition', 'Nursing Homes', 'Nutritio... | 19,264,381 | [['M01.060.116.100.080'], ['G07.345.124'], ['Z01.542.088'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['E05.318.372.550', 'E05.337.675', 'N05.715.360.330.550', 'N06.850.520.450.550'], ['E05... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Psychiatry and Psychology [F]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]... | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
The over-expression of an alfalfa RING-H2 gene induces pleiotropic effects on plant growth and development. | The alfalfa MsRH2-1 gene encodes a small protein with a RING-H2 motif and an N-terminal transmembrane domain. The transcript can be found in all tested plant organs, but roots and nodules show the highest levels of RH2-1 mRNA accumulation. Promoter-GUS fusion studies demonstrate that the activity of this gene is closel... | ['Amino Acid Sequence', 'Arabidopsis', 'Blotting, Northern', 'DNA, Plant', 'Gene Expression Regulation, Developmental', 'Gene Expression Regulation, Plant', 'Glucuronidase', 'Medicago sativa', 'Molecular Sequence Data', 'Plant Proteins', 'Plant Roots', 'Plants, Genetically Modified', 'Promoter Regions, Genetic', 'RNA, ... | 12,825,694 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.650.940.800.575.912.250.157.100'], ['E05.196.401.095', 'E05.301.300.074', 'E05.601.100'], ['D13.444.308.435'], ['G05.308.310'], ['G05.308.375'], ['D08.811.277.450.426'], ['B01.650.940.800.575.912.250.401.590.500'], ['L01.453.245.667'], ['D12.776.765'], ['A18.400'], ['B... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Methyl-selenium compounds inhibit prostate carcinogenesis in the transgenic adenocarcinoma of mouse prostate model with survival benefit. | Chemoprevention of prostate cancer by second-generation selenium compounds in reference to selenomethionine holds strong promise to deal with the disease at the root. Here we used the transgenic adenocarcinoma mouse prostate (TRAMP) model to establish the efficacy of methylseleninic acid (MSeA) and methylselenocysteine... | ['Adenocarcinoma', 'Animals', 'Antineoplastic Agents', 'Apoptosis', 'Blotting, Western', 'Cell Proliferation', 'Cysteine', 'Enzyme-Linked Immunosorbent Assay', 'In Situ Nick-End Labeling', 'Insulin-Like Growth Factor I', 'Male', 'Mice', 'Mice, Transgenic', 'Organoselenium Compounds', 'Prostatic Neoplasms', 'Selenocyste... | 19,401,524 | [['C04.557.470.200.025'], ['B01.050'], ['D27.505.954.248'], ['G04.146.954.035'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['G04.161.750', 'G07.345.249.410.750'], ['D02.886.030.230', 'D02.886.489.155', 'D12.125.154.299', 'D12.125.166.230'], ['E05.478.566.350.17... | ['Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
WEB-based GEne SeT AnaLysis Toolkit (WebGestalt): update 2013. | Functional enrichment analysis is an essential task for the interpretation of gene lists derived from large-scale genetic, transcriptomic and proteomic studies. WebGestalt (WEB-based GEne SeT AnaLysis Toolkit) has become one of the popular software tools in this field since its publication in 2005. For the last 7 years... | ['Gene Expression Profiling', 'Genes', 'Genomics', 'Humans', 'Internet', 'Protein Interaction Mapping', 'Proteomics', 'Software'] | 23,703,215 | [['E05.393.332'], ['G05.360.340.024.340'], ['H01.158.273.180.350', 'H01.158.273.343.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.230.110.500'], ['E05.601.690'], ['H01.158.201.843', 'H01.158.273.180.350.700', 'H01.158.273.343.350.700', 'H01.181.122.738'], ['L01.224.900']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Critical role of Ras in the proliferation and prevention of apoptosis mediated by IL-2. | Activation of the Ras small guanine nucleotide-binding proteins upon IL-2 stimulation of T lymphocytes has been described previously. However, the relevance of the Ras molecules in the cellular events triggered by IL-2 still remained to be clarified. To analyze the effects of Ras inhibition in early proliferative respo... | ['Animals', 'Apoptosis', 'Cell Line', 'Interleukin-2', 'Lymphocyte Activation', 'Mice', 'Mutation', 'T-Lymphocytes', 'Tetracycline', 'Transfection', 'ras Proteins'] | 8,805,624 | [['B01.050'], ['G04.146.954.035'], ['A11.251.210'], ['D12.644.276.374.465.021', 'D12.644.276.374.480.372', 'D12.776.467.374.465.021', 'D12.776.467.374.480.372', 'D23.529.374.465.155', 'D23.529.374.480.372'], ['E01.370.225.812.482', 'E05.200.812.482', 'E05.478.594.530', 'G12.450.050.400.545', 'G12.565'], ['B01.050.150.9... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Increased expression of SIM2-s protein is a novel marker of aggressive prostate cancer. | PURPOSE: The human SIM2 gene is located within the Down's syndrome critical region of chromosome 21 and encodes transcription factors involved in brain development and neuronal differentiation. SIM2 has been assigned a possible role in the pathogenesis of solid tumors, and the SIM2-short isoform (SIM2-s) was recently p... | ['Aged', 'Basic Helix-Loop-Helix Transcription Factors', 'Biomarkers, Tumor', 'Disease Progression', 'Gene Expression Regulation, Neoplastic', 'Humans', 'Immunohistochemistry', 'In Situ Hybridization', 'Ki-67 Antigen', 'Male', 'Middle Aged', 'Multivariate Analysis', 'Neoplasm Invasiveness', 'Oligonucleotide Array Seque... | 17,289,882 | [['M01.060.116.100'], ['D12.776.260.103', 'D12.776.930.125'], ['D23.101.140'], ['C23.550.291.656'], ['G05.308.370'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512', 'H01.158.20... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Contralateral hindlimb responses to cutaneous stimulation during locomotion in high decerebrate cats. | High intensity stimuli of the skin were delivered to one hindlimb in various parts of the step cycle of decerebrate cats walking on a treadmill. Whereas the stimulated limb always flexes after the stimulation there is, in the contralateral limb, a crossed flexion response during swing or a crossed extension response du... | ['Animals', 'Cats', 'Electromyography', 'Functional Laterality', 'Hindlimb', 'Locomotion', 'Mechanoreceptors', 'Muscle Contraction', 'Reflex', 'Skin', 'Spinal Cord'] | 7,470,911 | [['B01.050'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['E01.370.405.255', 'E01.370.530.255'], ['F02.830.297.425', 'G11.561.225.425'], ['A13.473'], ['G07.568.500', 'G11.427.410.568'], ['A08.675.650.915.750', 'A08.800.950.750', 'A11.671.650.915.750'], ['G11.427.494'], ['E01.370.376.550.650', 'E01.370.600.550.650... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Alpha-tocopheryl hydroquinone is an efficient multifunctional inhibitor of radical-initiated oxidation of low density lipoprotein lipids. | As the oxidation of low density lipoprotein (LDL) lipids may be a key event in atherogenesis, there is interest in antioxidants as potential anti-atherogenic compounds. Here we report that alpha-tocopheryl hydroquinone (alpha-TQH2) strongly inhibited or completely prevented the (per)oxidation of ubiquinol-10 (CoQ10H2),... | ['Coenzymes', 'Free Radical Scavengers', 'Humans', 'Lipoproteins, LDL', 'Oxidation-Reduction', 'Ubiquinone', 'Vitamin E', 'alpha-Tocopherol'] | 9,223,282 | [['D08.211'], ['D27.505.519.217.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D10.532.515', 'D12.776.521.550'], ['G02.700', 'G03.295.531'], ['D02.806.250.900', 'D08.211.935'], ['D03.383.663.283.909', 'D03.633.100.150.909'], ['D03.383.663.283.909.750.249', 'D03.633.100.150.909.750.249']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Leaks from laparoscopic cholecystectomy. | BACKGROUND/AIMS: Significant postoperative bile leaks occur in approximately 1% of patients. The goal of endoscopic therapy is to eliminate the transpapillary pressure gradient, thereby permitting preferential transpapillary bile flow rather than extravasation at the site of leak.METHODOLOGY: Sixty-four patients were r... | ['Adult', 'Aged', 'Biliary Fistula', 'Cholecystectomy, Laparoscopic', 'Drainage', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Middle Aged', 'Postcholecystectomy Syndrome', 'Retrospective Studies', 'Risk Factors', 'Sphincterotomy, Endoscopic', 'Stents'] | 12,143,242 | [['M01.060.116'], ['M01.060.116.100'], ['C06.267.150', 'C23.300.575.185.150'], ['E04.210.120.172.140', 'E04.502.250.520.160'], ['E02.309', 'E04.237'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C06.13... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Influence of socioeconomic factors on the adherence of alendronate treatment in incident users in Norway. | PURPOSE: To examine whether socioeconomic factors influence adherence to alendronate drug treatment among incident users in Norway during 2005-2009.METHODS: The study included 7610 incident alendronate users in 2005 (40-79 years), followed until 31 December 2009. Mean age was 66.6 years, and 86.7% of the patients were ... | ['Adult', 'Aged', 'Alendronate', 'Bone Density Conservation Agents', 'Cohort Studies', 'Databases, Factual', 'Drug Prescriptions', 'Female', 'Humans', 'Insurance, Health, Reimbursement', 'Male', 'Marital Status', 'Medication Adherence', 'Middle Aged', 'Multivariate Analysis', 'Norway', 'Osteoporosis', 'Prospective Stud... | 22,237,942 | [['M01.060.116'], ['M01.060.116.100'], ['D02.705.429.500.100'], ['D27.505.696.242'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['E02.319.307', 'N02.421.668.778.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.219.521.5... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Information Science [L]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]', 'Diseases [C]', 'Ph... | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
Genome-wide transcriptomic analysis of the response of Botrytis cinerea to wuyiencin. | Grey mould is caused by the ascomycetes Botrytis cinerea in a range of crop hosts. As a biological control agent, the nucleoside antibiotic wuyiencin has been industrially produced and widely used as an effective fungicide. To elucidate the effects of wuyiencin on the transcriptional regulation in B. cinerea, we, for t... | ['ATP-Binding Cassette Transporters', 'Antifungal Agents', 'Botrytis', 'Drug Resistance, Fungal', 'Fungal Proteins', 'Gene Expression Regulation, Fungal', 'Transcriptome', 'Up-Regulation'] | 32,348,310 | [['D12.776.157.530.100', 'D12.776.395.550.020', 'D12.776.543.550.192', 'D12.776.543.585.100'], ['D27.505.954.122.136'], ['B01.300.381.128'], ['G06.225.383', 'G07.690.773.984.269.383'], ['D12.776.354'], ['G05.308.330'], ['G02.111.873.750', 'G05.297.700.750', 'G05.360.920'], ['G02.111.905', 'G05.308.850', 'G07.690.773.99... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
An Ontology-Based Approach to Estimate the Frequency of Rare Diseases in Narrative-Text Radiology Reports. | This study sought to use ontology-based knowledge to identify patients with rare diseases and to estimate the frequency of those diseases in a large database of radiology reports. Natural language processing methods were applied to 12,377,743 narrarive-text radiology reports of 7,803,811 patients at an academic health ... | ['Biological Ontologies', 'Humans', 'Information Storage and Retrieval', 'Narration', 'Natural Language Processing', 'Radiology', 'Radiology Information Systems', 'Rare Diseases'] | 29,295,229 | [['L01.224.050.375.480.500', 'L01.313.500.750.300.550.500', 'L01.453.245.945.079'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.313.500.750.280', 'L01.470'], ['E05.318.308.502', 'F01.145.209.459', 'L01.399.250.660', 'N05.715.360.300.480', 'N06.850.520.308.502'], ['L01.224.050.375.580'], ['H02.403.740'], ['N0... | ['Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
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