Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Cell division and targeted cell cycle arrest opens and stabilizes basement membrane gaps. | Large gaps in basement membrane (BM) occur during organ remodelling and cancer cell invasion. Whether dividing cells, which temporarily reduce their attachment to BM, influence these breaches is unknown. Here we analyse uterine-vulval attachment during development across 21 species of rhabditid nematodes and find that ... | ['Animals', 'Basement Membrane', 'Caenorhabditis elegans', 'Caenorhabditis elegans Proteins', 'Cell Cycle Checkpoints', 'Female', 'Laminin', 'Vulva'] | 24,924,309 | [['B01.050'], ['A10.272.220', 'A10.615.179'], ['B01.050.500.500.294.400.875.660.250.250'], ['D12.776.419.500'], ['G04.144.109'], ['D12.776.395.550.530', 'D12.776.543.550.500', 'D12.776.860.300.675'], ['A05.360.319.887']] | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Efficacy of remission induction chemotherapy and prognostic analysis in elderly patients with acute myeloid leukemia]. | OBJECTIVE: To explore the outcome of remission induction chemotherapy (IC) and prognostic in elderly patients with acute myeloid leukemia (AML).METHODS: The clinical data of 156 AML patients older than 60 years in the Institute of Hematology, Union Hospital of Fujian Medical University from January 2003 to July 2010 we... | ['Aged', 'Aged, 80 and over', 'Female', 'Humans', 'Induction Chemotherapy', 'Leukemia, Myeloid, Acute', 'Male', 'Middle Aged', 'Prognosis', 'Retrospective Studies'] | 22,730,652 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.499', 'E02.860.500'], ['C04.557.337.539.275'], ['M01.060.116.630'], ['E01.789'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.520.450... | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Physicians--victims or promoters of corruption?]. | According to the media the recent physician bribery scandal in Germany draws ever further sets. The public prosecutor determines against hospital physicians and coworkers of a pharmaceutical firm. The suspicion: Physicians were recompensed for using up medicines particularly with pleasure trips. Which is qualified in G... | ['Conflict of Interest', 'Drug Industry', 'Ethics, Medical', 'Fraud', 'Germany', 'Humans', "Physician's Role", 'Research Support as Topic'] | 12,094,402 | [['K01.752.566.479.095', 'N05.350.225'], ['J01.576.655.750'], ['K01.752.566.479.171.132.750', 'N05.350.340.162.500'], ['I01.198.240.300'], ['Z01.542.315'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.316.616.625.600'], ['N03.219.483.645']] | ['Humanities [K]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 |
Effect of steroid hormones on membrane profiles of HeLa S3 cells. | The cervical carcinoma cell line, HeLa S3, was exposed to oestradiol and progesterone separately and combined in ratios similar to those of the luteal and follicular phases of the menstrual cycle. After 48 h of exposure, membrane proteins were extracted from the plasma membrane and analyzed. The lipid composition of th... | ['Cell Membrane', 'Chromatography', 'Down-Regulation', 'Estradiol', 'Glycosylation', 'HeLa Cells', 'Humans', 'Lectins', 'Lipid Metabolism', 'Progesterone', 'Time Factors', 'Up-Regulation'] | 11,237,413 | [['A11.284.149'], ['E05.196.181'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['D04.210.500.365.415.248', 'D06.472.334.851.437.500'], ['G02.111.158.812', 'G02.607.299', 'G03.191.812'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.503']... | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Identification in Xenopus laevis of a class of oocyte-specific proteins bound to messenger RNA. | Proteins associated with poly(A)-rich RNA in Xenopus laevis oocytes have been identified in immature ovary homogenates using sucrose gradient centrifugation, oligo(dT)-cellulose fractionation and analysis by sodium dodecyl sulphate/polyacrylamide gel electrophoresis and two-dimensional acid/urea/sodium dodecyl sulphate... | ['Animals', 'Cytoplasm', 'Female', 'Molecular Weight', 'Nucleoproteins', 'Oocytes', 'Oogenesis', 'Ovum', 'Poly A', 'RNA, Messenger', 'Ribonucleases', 'Ribonucleoproteins', 'Xenopus laevis'] | 7,215,334 | [['B01.050'], ['A11.284.430.214'], ['G02.494'], ['D12.776.664'], ['A05.360.490.690.680', 'A11.497.497.600'], ['G04.152.650.249', 'G08.686.784.310.500'], ['A05.360.490.690', 'A11.497.497', 'A16.690'], ['D13.695.578.550.500'], ['D13.444.735.544'], ['D08.811.277.352.700'], ['D12.776.157.725.500', 'D12.776.664.962.500'], [... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Is analgesia required for transvaginal single-follicle aspiration in in vitro fertilization? A double-blind study. | High oocyte retrieval rates using transvaginal follicular aspiration for single follicles and improved laboratory techniques have engendered renewed interest in natural-cycle in vitro fertilization (IVF). To assess analgesia requirements during single-follicle aspiration, a double-blind study was set up in 30 patients ... | ['Analgesia', 'Double-Blind Method', 'Female', 'Fentanyl', 'Fertilization in Vitro', 'Humans', 'Ovarian Follicle', 'Pain Measurement', 'Ultrasonography', 'Vagina'] | 2,193,071 | [['E03.091'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['D03.383.621.265'], ['E02.875.800.750', 'E05.820.800.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A05.360.319.114.630.535', 'A06.300.312.497.535'], ['E01.370.600.550.324'], ['E01.370.350.850'], ['A05.360.31... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Increased frequency of the long (S) allotype of CR1 (the C3b/C4b receptor, CD35) in patients with systemic lupus erythematosus. | The allotypic forms of the C3b/C4b receptor (CR1, CD35) differ in length, in the number of expressed C3b binding sites and thus in their ability to mediate the processing of circulating C3- and C4-bearing immune complexes. We have used a combination of three informative restriction fragment length polymorphisms (RFLPs)... | ['Blotting, Southern', 'DNA', 'European Continental Ancestry Group', 'France', 'Gene Frequency', 'Humans', 'Isoantigens', 'Lupus Erythematosus, Systemic', 'Polymorphism, Restriction Fragment Length', 'Receptors, Complement', 'Receptors, Complement 3b'] | 1,352,746 | [['E05.196.401.114', 'E05.301.300.087', 'E05.601.150'], ['D13.444.308'], ['M01.686.508.400'], ['Z01.542.286'], ['G05.330'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D23.050.705'], ['C17.300.480', 'C20.111.590'], ['G05.365.795.595'], ['D12.776.543.750.705.833'], ['D12.776.543.750.705.833.600']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Named Groups [M]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
Digital single-operator cholangioscopy: a useful tool for selective guidewire placements across complex biliary strictures. | BACKGROUND: Treatment of biliary strictures is challenging. Digital single-operator cholangioscopes (SOCs) equipped with an improved imaging quality, were recently introduced and may be useful for selective guidewire placement in difficult biliary strictures.METHODS: A total of 167 digital SOC procedures performed betw... | ['Adult', 'Bile Duct Neoplasms', 'Bile Ducts', 'Biliary Tract Surgical Procedures', 'Catheterization', 'Cholangitis', 'Cholestasis', 'Constriction, Pathologic', 'Endoscopy, Digestive System', 'Female', 'Humans', 'Liver Transplantation', 'Male', 'Middle Aged', 'Pancreatitis', 'Retrospective Studies'] | 30,006,839 | [['M01.060.116'], ['C04.588.274.120.250', 'C06.130.120.120', 'C06.130.320.120', 'C06.301.120.250'], ['A03.159.183'], ['E04.210.120'], ['E02.148', 'E05.157'], ['C06.130.120.200'], ['C06.130.120.135'], ['C23.300.287'], ['E01.370.372.250', 'E01.370.388.250.250', 'E04.210.240', 'E04.502.250.250'], ['B01.050.150.900.649.313... | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Socioeconomic factors related to attendance at a Type 2 diabetes screening programme. | AIMS: The prevalence of diabetes is increasing, and screening of high-risk populations is recommended. A low attendance rate has been observed in many Type 2 diabetes screening programmes, so that an analysis of factors related to attendance is therefore relevant. This paper analyses the association between socioeconom... | ['Adult', 'Aged', 'Cross-Sectional Studies', 'Denmark', 'Diabetes Mellitus, Type 2', 'Family Practice', 'Female', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Male', 'Mass Screening', 'Middle Aged', 'Patient Acceptance of Health Care', 'Socioeconomic Factors', 'Surveys and Questionnaires'] | 19,646,192 | [['M01.060.116'], ['M01.060.116.100'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['Z01.542.816.124'], ['C18.452.394.750.149', 'C19.246.300'], ['H02.403.340.500'], ['F01.100.150.500', 'N05.300.150.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.500', 'E05.318.308.98... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Diseases [C]', 'Disciplines and Occupations [H]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
The relationship of anxious and depressive symptoms in Parkinson's disease with voxel-based neuroanatomical and functional connectivity measures. | BACKGROUND: Anxiety and depression are two frequent comorbidities of Parkinson's disease (PD). However, the underlying neural mechanism is still unclear and the studies on their neural correlates were insufficient.METHODS: Using voxel-based neuroanatomical and functional connectivity (FC) measures, i.e. grey matter vol... | ['Aged', 'Amygdala', 'Anxiety', 'Cross-Sectional Studies', 'Depression', 'Emotions', 'Female', 'Gray Matter', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Neural Pathways', 'Parietal Lobe', 'Parkinson Disease', 'Temporal Lobe'] | 30,439,681 | [['M01.060.116.100'], ['A08.186.211.180.090', 'A08.186.211.200.885.287.249.152'], ['F01.470.132'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['F01.145.126.350'], ['F01.470'], ['A08.186.211.168', 'A08.186.854.348'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.5... | ['Named Groups [M]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Statistical estimation of gene expression using multiple laser scans of microarrays. | UNLABELLED: We propose a statistical model for estimating gene expression using data from multiple laser scans at different settings of hybridized microarrays. A functional regression model is used, based on a non-linear relationship with both additive and multiplicative error terms. The function is derived as the expe... | ['Algorithms', 'Data Interpretation, Statistical', 'Gene Expression Profiling', 'Image Interpretation, Computer-Assisted', 'In Situ Hybridization, Fluorescence', 'Microscopy, Confocal', 'Microscopy, Fluorescence', 'Models, Genetic', 'Models, Statistical', 'Oligonucleotide Array Sequence Analysis', 'Reproducibility of R... | 16,303,798 | [['G17.035', 'L01.224.050'], ['E05.245.380', 'E05.318.740.300', 'L01.313.500.750.190.380', 'N05.715.360.750.300', 'N06.850.520.830.300'], ['E05.393.332'], ['E01.158.600', 'E01.370.350.350', 'L01.313.500.750.100.158.600'], ['E01.370.225.500.620.670.325.350', 'E01.370.225.750.600.670.325.350', 'E05.200.500.620.670.325.35... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Pediatric Intestinal Failure-Associated Liver Disease: Challenges in Identifying Clinically Relevant Biomarkers. | BACKGROUND: Intestinal failure-associated liver disease (IFALD) is complex and diagnosed by concurrent use of parenteral nutrition, clinical presentation, and alterations in hepatic biomarkers exclusive of other causes of liver disease. In comparison with individual measures, composite biomarkers may provide a more eff... | ['Adolescent', 'Adult', 'Alanine Transaminase', 'Alkaline Phosphatase', 'Bilirubin', 'Biomarkers', 'Child', 'Child, Preschool', 'Female', 'Humans', 'Infant', 'Intestinal Diseases', 'Intestines', 'Liver Diseases', 'Male', 'Middle Aged', 'Young Adult', 'gamma-Glutamyltransferase'] | 29,443,401 | [['M01.060.057'], ['M01.060.116'], ['D08.811.913.477.700.100'], ['D08.811.277.352.650.035'], ['D03.383.129.578.840.249.184', 'D03.633.400.909.249.184', 'D04.345.783.249.184', 'D23.767.193.184'], ['D23.101'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['C06.40... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Microencapsulation, chemical characterization, and antimicrobial activity of Mexican (Lippia graveolens H.B.K.) and European (Origanum vulgare L.) oregano essential oils. | The effect of solvent polarity (methanol and pentane) on the chemical composition of hydrodistilled essential oils (EO's) of Lippia graveolens H.B.K. (MXO) and Origanum vulgare L. (EUO) was studied by GC-MS. Composition of modified starch microencapsulated EO's was conducted by headspace-solid-phase microextraction (HS... | ['Anti-Bacterial Agents', 'Bicyclic Monoterpenes', 'Brochothrix', 'Capsules', 'Cyclohexane Monoterpenes', 'Cymenes', 'Lactobacillus plantarum', 'Lippia', 'Micrococcus luteus', 'Monoterpenes', 'Oils, Volatile', 'Origanum', 'Pseudomonas fragi', 'Salmonella', 'Starch', 'Thymol'] | 25,177,730 | [['D27.505.954.122.085'], ['D02.455.426.100.080.050', 'D02.455.849.575.141'], ['B03.353.500.120', 'B03.510.100.120', 'B03.510.460.400.410.120'], ['D26.255.150'], ['D02.455.426.392.368.367.211', 'D02.455.849.575.157'], ['D02.455.426.559.389.310', 'D02.455.849.575.219'], ['B03.353.750.450.475.612', 'B03.510.460.400.410.4... | ['Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Characterizing breast cancer treatment pathways in Kumasi, Ghana from onset of symptoms to final outcome: outlook towards cancer control. | BACKGROUND: Cancer rates are increasing in Africa, including Ghana. Breast cancer is the second most common cancer in incidence and mortality in Ghana.OBJECTIVE: We outlined both breast cancer patient characteristics and management at the Komfo Anokye Teaching Hospital (KATH), the main cancer management hospital in cen... | ['Adult', 'Aged', 'Breast Neoplasms', 'Female', 'Ghana', 'Humans', 'Logistic Models', 'Middle Aged', 'Patient Acceptance of Health Care'] | 24,934,170 | [['M01.060.116'], ['M01.060.116.100'], ['C04.588.180', 'C17.800.090.500'], ['Z01.058.290.190.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.525', 'E05.318.740.600.800.450', 'E05.318.740.750.450', 'E05.599.835.875', 'N05.715.360.750.530.480', 'N05.715.360.750.625.700.450', 'N05.715.360.750.695... | ['Named Groups [M]', 'Diseases [C]', 'Geographicals [Z]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Determination of non-bilayer phospholipid arrangements and their antibodies in placentae and sera of patients with hypertensive disorders of pregnancy. | Studies suggest that preeclampsia (PE) originates in the placenta and is associated with deficient trophoblast invasion of spiral arteries. The direct cause remains unknown, but preeclampsia is often associated with circulating factors that can induce generalized endothelial dysfunction. Antiphospholipid antibodies (AP... | ['Antibodies, Antiphospholipid', 'Female', 'Fetal Growth Retardation', 'Humans', 'Membrane Lipids', 'Phospholipids', 'Placenta', 'Pre-Eclampsia', 'Pregnancy'] | 16,338,467 | [['D12.776.124.486.485.114.323.210', 'D12.776.124.790.651.114.323.210', 'D12.776.377.715.548.114.323.210'], ['C13.703.277.370', 'C16.300.390', 'C23.550.393.450'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D10.570'], ['D10.570.755'], ['A16.710'], ['C13.703.395.249'], ['G08.686.784.769']] | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell cycle-dependent expression of cyclin D1 and a 45 kD protein in human A549 lung carcinoma cells. | Cyclin D1, which is suggested to have a role in G1 control during the cell cycle, is genetically linked to BCL-1 and is widely overexpressed in parathyroid, breast, and squamous cancer cells. We postulated that cyclin D1 regulation may also be important in lung cancer. Therefore, we characterized the cell cycle-depende... | ['Amino Acid Sequence', 'Amino Acids', 'Animals', 'Carcinoma', 'Cell Transformation, Neoplastic', 'Cells, Cultured', 'Cyclin D1', 'Cyclins', 'Gene Expression Regulation, Neoplastic', 'Humans', 'Interphase', 'Lung', 'Lung Neoplasms', 'Molecular Sequence Data', 'Molecular Weight', 'Oligopeptides', 'Oncogene Proteins', 'P... | 8,136,159 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D12.125'], ['B01.050'], ['C04.557.470.200'], ['C04.697.098.500', 'C23.550.727.098.500'], ['A11.251'], ['D12.644.360.262.150.100', 'D12.776.167.218.150.100', 'D12.776.476.262.150.100', 'D12.776.624.664.700.100'], ['D12.644.360.262', 'D12.776.167.218', 'D12.776.476.262'], ['... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Laparoscopic-assisted nephrectomy with inferior vena cava tumor thrombectomy: preliminary results. | OBJECTIVES: To evaluate the feasibility and outcome of laparoscopic-assisted radical nephrectomy and inferior vena cava (IVC) tumor thrombectomy in patients with renal cell carcinoma and level I IVC tumor thrombus.METHODS: The clinical, operative, and pathologic data were retrospectively obtained from patients undergoi... | ['Aged', 'Carcinoma, Renal Cell', 'Feasibility Studies', 'Follow-Up Studies', 'Humans', 'Kidney Neoplasms', 'Laparoscopy', 'Length of Stay', 'Male', 'Middle Aged', 'Neoplasm Invasiveness', 'Nephrectomy', 'Retrospective Studies', 'Thrombectomy', 'Thrombosis', 'Vena Cava, Inferior'] | 15,533,479 | [['M01.060.116.100'], ['C04.557.470.200.025.390', 'C04.588.945.947.535.160', 'C12.758.820.750.160', 'C12.777.419.473.160', 'C13.351.937.820.535.160', 'C13.351.968.419.473.160'], ['E05.318.372.550', 'E05.337.675', 'N05.715.360.330.550', 'N06.850.520.450.550'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', '... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Initial Series of Four-Arm Robotic Completely Intracorporeal Ileal Ureter. | Ileal ureter formation has been found to be a suitable treatment option for long, chronic ureteral strictures not amendable to less invasive forms of repair. Minimally invasive surgical techniques for this condition have been investigated. We report the first series of robotic completely intracorporeal ileal ureter usi... | ['Adult', 'Blood Loss, Surgical', 'Carcinoma, Transitional Cell', 'Constriction, Pathologic', 'Humans', 'Ileum', 'Intestinal Volvulus', 'Male', 'Middle Aged', 'Operative Time', 'Postoperative Complications', 'Reoperation', 'Robotic Surgical Procedures', 'Ureter', 'Ureteral Neoplasms', 'Ureteral Obstruction'] | 26,859,439 | [['M01.060.116'], ['C23.550.414.300', 'C23.550.505.300'], ['C04.557.470.200.430'], ['C23.300.287'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A03.556.124.684.249', 'A03.556.249.124'], ['C06.405.469.531.568', 'C23.300.970.500'], ['M01.060.116.630'], ['E04.614.374.500', 'N02.421.585.753.374.500'], ['C23.550.767'... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Benzyl butyl phthalate induces epigenetic stress to enhance adipogenesis in mesenchymal stem cells. | Endocrine disruptors, phthalates, may have contributed to recent global obesity health crisis. Our study investigated the potential of benzyl butyl phthalate (BBP) to regulate the mesenchymal stem cell epigenome to drive adipogenesis. BBP exposure enhanced lipid accumulation and adipogenesis in a dose-dependent manner ... | ['Acetylation', 'Adipogenesis', 'Animals', 'CCAAT-Enhancer-Binding Protein-alpha', 'Cell Line', 'Endocrine Disruptors', 'Epigenesis, Genetic', 'Epigenomics', 'Gene Expression', 'Histone Methyltransferases', 'Histone-Lysine N-Methyltransferase', 'Mesenchymal Stem Cells', 'Mice', 'PPAR gamma', 'Phthalic Acids'] | 27,164,441 | [['G02.111.012.052', 'G02.607.063.052', 'G03.040.052'], ['G04.152.149'], ['B01.050'], ['D12.776.260.108.124.500', 'D12.776.660.167.500', 'D12.776.930.127.124.500'], ['A11.251.210'], ['D27.505.696.353', 'D27.888.141'], ['G05.308.203'], ['H01.158.273.180.350.074', 'H01.158.273.343.350.042'], ['G05.297'], ['D08.811.913.55... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Poly(Amido Amine)s Containing Agmatine and Butanol Side Chains as Efficient Gene Carriers. | A new type of bioreducible poly(amido amine) copolymer is synthesized by the Michael addition polymerization of cystamine bisacrylamide (CBA) with 4-aminobutylguanidine (agmatine, AGM) and 4-aminobutanol (ABOL). Since the positively charged guanidinium groups of AGM and the hydroxybutyl groups of ABOL in the side chain... | ['Agmatine', 'Amino Alcohols', 'Cell Line, Tumor', 'Cell Survival', 'Cystamine', 'Epithelial Cells', 'Gene Expression', 'Genes, Reporter', 'HEK293 Cells', 'Humans', 'Lactates', 'Luciferases', 'Mesenchymal Stem Cells', 'Oxidation-Reduction', 'Polymerization', 'Transfection'] | 26,663,734 | [['D02.078.370.060'], ['D02.033.100', 'D02.092.063'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.346'], ['D02.092.471.200'], ['A11.436'], ['G05.297'], ['G05.360.340.024.340.435'], ['A11.251.210.172.750', 'A11.436.334'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.241.511.459'], ['D08.811.682.517', 'D12.77... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Role of Leishmania (Leishmania) amazonensis amastigote glycosphingolipids in macrophage infectivity. | The role of glycosphingolipids (GSLs) present in amastigote forms of Leishmania (Leishmania) amazonensis during infection of macrophages was analyzed, with particular emphasis on GSLs presenting the terminal Galpss1-3Galpa disaccharide. Macrophage invasion by L. (L.) amazonensis amastigotes was reduced by 37% when the ... | ['Animals', 'Antibodies, Monoclonal', 'Blotting, Western', 'Cricetinae', 'Electrophoresis, Polyacrylamide Gel', 'Glycosphingolipids', 'Leishmania mexicana', 'Macrophages', 'Mice', 'Mice, Inbred BALB C'] | 17,581,678 | [['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['B01.050.150.900.649.313.992.635.075.250'], ['E05.196.401.402', 'E05.301.300.319'], ['D09.400.410.420', 'D10.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Stimulation and suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase in normal human fibroblasts by high density lipoprotein subclasses. | Plasma concentrations of high density lipoproteins, (HDL3), a subclass of HDL, are relatively constant, while those of HDL2 are variable. We report that HDL2 suppress, while HDL3 stimulate 3-hydroxy-3-methylglutaryl-CoA reductase (EC 1.1.1.34) activity in normal human fibroblasts. HDL3, which contained no detectable HD... | ['Apolipoproteins', 'Cells, Cultured', 'Fatty Acids', 'Humans', 'Hydroxymethylglutaryl CoA Reductases', 'Immunoelectrophoresis', 'Infant, Newborn', 'Lipoproteins, HDL', 'Skin', 'Sterols'] | 7,407,213 | [['D10.532.091', 'D12.776.070.400', 'D12.776.521.120'], ['A11.251'], ['D10.251'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.682.047.820.150.415'], ['E01.370.225.812.735.645.350.350', 'E05.196.401.568', 'E05.200.812.735.645.350.350', 'E05.301.300.568', 'E05.478.594.760.645.350.350', 'E05.478.605.492.350... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Selecting an acoustic correlate for automated measurement of American English rhotic production in children. | Purpose: A current need in the field of speech-language pathology is the development of reliable and efficient techniques to evaluate accuracy of speech targets over the course of treatment. As acoustic measurement techniques improve, it should become possible to use automated scoring in lieu of ratings from a trained ... | ['Algorithms', 'Child', 'Female', 'Humans', 'Male', 'Speech Acoustics', 'Speech Production Measurement', 'Speech Recognition Software', 'Speech-Language Pathology'] | 28,795,872 | [['G17.035', 'L01.224.050'], ['M01.060.406'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G11.561.812.650', 'G11.561.820'], ['E01.370.760'], ['L01.224.900.889'], ['H02.010.750']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 |
Kinetic measurement of the urinary production rate of cortisol in male piglets: is the prerequisite 'collection until all label has disappeared' necessary? | Urinary cortisol production rate (CPR) was calculated by two different methods in five male piglets (about 3 kg bodyweight) injected i.v. with 40-120 kBq tritiated cortisol ([3H]F. After administration of [3H]F, urine was obtained from four consecutive collections for the following 2 days, during which 80-100% of the l... | ['Animals', 'Half-Life', 'Hydrocortisone', 'Kinetics', 'Male', 'Mathematics', 'Swine', 'Tetrahydrocortisol', 'Tetrahydrocortisone', 'Time Factors', 'Tritium'] | 3,805,969 | [['B01.050'], ['G01.910.405'], ['D04.210.500.745.745.654.600', 'D06.472.040.585.353.476', 'D06.472.040.585.478.392'], ['G01.374.661', 'G02.111.490'], ['H01.548'], ['B01.050.150.900.649.313.500.880'], ['D04.210.500.745.887', 'D06.472.040.585.353.825', 'D06.472.040.585.478.782'], ['D04.210.500.745.558.783', 'D06.472.040.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
[Disease of the left coronary trunk. Our experience. An analysis of surgical morbimortality]. | INTRODUCTION AND OBJECTIVES: The superiority of surgical treatment over other procedures in the left main coronary artery stenosis is well known, being today the therapy of choice. The purpose of this work is to analyze the clinical characteristics and the immediate results of surgery in our patients.PATIENTS AND METHO... | ['Adult', 'Age Distribution', 'Aged', 'Aged, 80 and over', 'Analysis of Variance', 'Chi-Square Distribution', 'Coronary Disease', 'Female', 'Hospital Mortality', 'Humans', 'Male', 'Middle Aged', 'Postoperative Complications', 'Retrospective Studies', 'Sex Distribution', 'Spain'] | 9,026,839 | [['M01.060.116'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['C14.280.647.250', 'C14.907.585.250'], ... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Clinical outcomes of wavefront-guided laser in situ keratomileusis: 6-month follow-up. | PURPOSE: To evaluate the clinical outcomes 6 months after wavefront-guided laser in situ keratomileusis (LASIK) for myopia in Japan.SETTING: Department of Ophthalmology, Sanno Hospital, Tokyo, Japan.METHODS: This prospective study comprised 22 eyes of 12 patients treated with wavefront-guided LASIK who were available f... | ['Adult', 'Cornea', 'Female', 'Follow-Up Studies', 'Humans', 'Keratomileusis, Laser In Situ', 'Male', 'Middle Aged', 'Myopia', 'Postoperative Complications', 'Prospective Studies', 'Safety', 'Treatment Outcome', 'Visual Acuity'] | 12,954,297 | [['M01.060.116'], ['A09.371.060.217'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.594.480.750', 'E04.014.520.480.750', 'E04.378.500.750', 'E04.540.825.437.374'], ['M01.060.116.630'], ['C11.744.636'], ['C23.550.767'], ... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Genome variants of human adenovirus 40 (subgroup F). | Twenty-six strains of faecal adenovirus from three continents (two from Europe, 16 from South Africa, and eight from Canada) were typed as Ad40 by restriction enzyme analysis of the DNA using Sma I. The DNA of the strains was further compared by digestion with six other enzymes, namely Bam HI, Eco RI, Bgl I, Xho I, Sst... | ['Adenoviridae Infections', 'Adenoviruses, Human', 'DNA Restriction Enzymes', 'DNA, Viral', 'Diarrhea, Infantile', 'Feces', 'Genes, Viral', 'Humans', 'Virus Cultivation'] | 6,094,722 | [['C01.925.256.076'], ['B04.280.030.500.350'], ['D08.811.150.280', 'D08.811.277.352.335.350.300', 'D08.811.277.352.355.325.300'], ['D13.444.308.568'], ['C23.888.821.214.500'], ['A12.459'], ['G05.360.340.024.340.364.875', 'G05.360.340.358.024.875', 'G05.360.340.358.840.500'], ['B01.050.150.900.649.313.988.400.112.400.40... | ['Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Surgical treatment of active infective endocarditis--early and late results of active native and prosthetic valve endocarditis. | The purpose of this study was to determine the clinical predictors of active infective endocarditis in 45 cases we treated between January 1971 and August 1991 (30 native valve endocarditis (NVE) and 15 prosthetic valve endocarditis (PVE). The indication of surgery in 45 patients was progressive congestive heart failur... | ['Abscess', 'Adolescent', 'Adult', 'Aged', 'Aortic Valve', 'Child', 'Endocarditis, Bacterial', 'Female', 'Heart Valve Diseases', 'Heart Valve Prosthesis', 'Humans', 'Male', 'Middle Aged', 'Mitral Valve', 'Prognosis', 'Prosthesis-Related Infections', 'Retrospective Studies', 'Staphylococcal Infections', 'Survival Rate'] | 8,230,684 | [['C01.830.025', 'C23.550.470.756.100'], ['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['A07.541.510.110'], ['M01.060.406'], ['C01.150.252.245', 'C01.190.249', 'C14.260.249', 'C14.280.282.407'], ['C14.280.484'], ['E07.695.310'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['A07.541.51... | ['Diseases [C]', 'Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Within-session score gains for repeat examinees on a standardized patient examination. | PURPOSE: Previous studies on standardized patient (SP) exams reported score gains both across attempts when examinees failed and retook the exam and over multiple SP encounters within a single exam session. The authors analyzed the within-session score gains of examinees who repeated the United States Medical Licensing... | ['Canada', 'Clinical Competence', 'Educational Measurement', 'Humans', 'Licensure, Medical', 'Models, Statistical', 'Physical Examination', 'Regression Analysis', 'United States'] | 23,524,920 | [['Z01.107.567.176'], ['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['I02.399'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.706.110.510.410', 'N05.700.200.450.500'], ['E05.318.740.500', 'E05.599.835', 'N05.715.360.750.530', 'N06.850.520.830.500'], ['E01.370.600'], ['E05.318.740.750', 'N05.715.360.750.6... | ['Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Specific pattern of p53 phosphorylation during nitric oxide-induced cell cycle arrest. | Nitric oxide (NO) is an efficient inhibitor of cell proliferation. Here we show that part of the antiproliferative activity of NO in fibroblasts is mediated through p53 signaling pathway. Cells from p53-/- knockout mice are compromised in their ability to stop dividing in the presence of NO. NO strongly induces express... | ['3T3 Cells', 'Animals', 'Cell Cycle', 'Cell Division', 'Doxorubicin', 'Fibroblasts', 'Gamma Rays', 'Gene Expression Profiling', 'Mice', 'Mice, Knockout', 'Nitric Oxide', 'Phosphorylation', 'Signal Transduction', 'Transcriptional Activation', 'Tumor Suppressor Protein p53', 'Ultraviolet Rays'] | 11,175,352 | [['A11.251.210.100', 'A11.329.228.100'], ['B01.050'], ['G04.144'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['D02.455.426.559.847.562.050.200.175', 'D04.615.562.050.200.175', 'D09.408.051.059.200.175'], ['A11.329.228'], ['G01.358.500.505.300', 'G01.750.250.300', 'G01.750.750.400'], ['E0... | ['Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Increased Retinal Thinning after Combination of Internal Limiting Membrane Peeling and Silicone Oil Endotamponade in Proliferative Diabetic Retinopathy. | BACKGROUND: The aim of this study was to examine the change in retinal thickness after vitrectomy with internal limiting membrane (ILM) peeling and/or silicone oil (SO) endotamponade in proliferative diabetic retinopathy (PDR).METHODS: The actual amount and ratio of changes in the retinal thickness were calculated.RESU... | ['Aged', 'Basement Membrane', 'Diabetic Retinopathy', 'Endotamponade', 'Female', 'Humans', 'Male', 'Middle Aged', 'Retina', 'Retrospective Studies', 'Silicone Oils', 'Tomography, Optical Coherence', 'Visual Acuity', 'Vitrectomy'] | 28,854,441 | [['M01.060.116.100'], ['A10.272.220', 'A10.615.179'], ['C11.768.257', 'C14.907.320.382', 'C19.246.099.500.382'], ['E02.520.392'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['A09.371.729'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.... | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
[Digestive and cutaneous colonization of Staphylococcus epidermidis in hairless axenic mice]. | In order to determine the cutaneous and digestive colonization of S. epidermidis in germ-free HRS mice, several groups of animals were contaminated with this strain according to different methods. The bacterial cutaneous enumerations were performed after preliminary crushing of the cutaneous biopsy. In this study, what... | ['Animals', 'Digestive System', 'Disease Models, Animal', 'Female', 'Germ-Free Life', 'Male', 'Mice', 'Mice, Hairless', 'Skin', 'Staphylococcal Infections', 'Staphylococcus epidermidis'] | 6,721,329 | [['B01.050'], ['A03'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['G06.320'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.200', 'B01.050.150.900.649.313.992.635.505.500.400.200', 'B01.050.150.900.649.313.992.635.505.500.550.230'], ['A17.815'], ['C01.150.252.410.868'], ['B03.300.390.400.8... | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Perceived discrimination at work for being an immigrant: a study on self-perceived mental health status among immigrants in Italy]. | BACKGROUND: exposure to discrimination is widely understood as a social determinant of psychophysical health and a contributing factor to health inequities among social groups. Few studies exist, particularly in Italy, about the effects of discrimination among immigrants at workplace.OBJECTIVES: to analyse the associat... | ['Adult', 'Emigrants and Immigrants', 'Female', 'Health Status', 'Humans', 'Italy', 'Male', 'Mental Disorders', 'Middle Aged', 'Prejudice', 'Self Concept', 'Surveys and Questionnaires', 'Workplace'] | 28,929,725 | [['M01.060.116'], ['M01.189'], ['I01.240.425', 'N01.224.425', 'N06.850.505.400.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.542.489'], ['F03'], ['M01.060.116.630'], ['F01.145.813.550', 'F01.829.595'], ['F01.752.747.792'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980'], ['N01.824.245.... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Effect of prostacyclin on cardiac transmembrane currents. | The relatively stable sodium salt of prostacyclin, PGI2-Na, kindly supplied by Chinoin Works (Budapest), was found to induce a dose-dependent increase in the inward-going membrane current of the sinoauricular fiber of the frog. Threshold concentration was 0.05 microgram/ml, and maximal effect was reached at a concentra... | ['Animals', 'Electrocardiography', 'Epinephrine', 'Epoprostenol', 'Ion Channels', 'Myocardial Contraction', 'Prostaglandins', 'Ranidae', 'Sinoatrial Node', 'Tetrodotoxin'] | 6,302,755 | [['B01.050'], ['E01.370.370.380.240', 'E01.370.405.240'], ['D02.033.100.291.310', 'D02.092.063.291.310', 'D02.092.211.215.454', 'D02.092.311.461', 'D02.455.426.559.389.657.166.175.461'], ['D10.251.355.255.550.550.500', 'D23.469.050.175.725.550.500'], ['D12.776.157.530.400', 'D12.776.543.550.450', 'D12.776.543.585.400']... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Affinity Maturation of Monoclonal Antibody 1E11 by Targeted Randomization in CDR3 Regions Optimizes Therapeutic Antibody Targeting of HER2-Positive Gastric Cancer. | Anti-HER2 murine monoclonal antibody 1E11 has strong and synergistic anti-tumor activity in HER2-overexpressing gastric cancer cells when used in combination with trastuzumab. We presently optimized this antibody for human therapeutics. First, the complementarity determining regions (CDRs) of the murine antibody were g... | ['Amino Acid Sequence', 'Animals', 'Antibodies, Monoclonal, Humanized', 'Antibody Affinity', 'Cell Line, Tumor', 'Complementarity Determining Regions', 'Female', 'Genes, erbB-2', 'Humans', 'Mice', 'Mice, Nude', 'Molecular Sequence Data', 'Sequence Homology, Amino Acid', 'Stomach Neoplasms'] | 26,225,765 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D12.776.124.486.485.114.224.060', 'D12.776.124.790.651.114.224.060', 'D12.776.377.715.548.114.224.200'], ['G12.040', 'G12.122.125'], ['A11.251.210.190', 'A11.251.860.180'], ['D12.644.541.500.650.500.180', 'D12.776.124.486.485.680.650.500.180', 'D12.776.124.486... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Minimal fluorous tagging strategy that enables the synthesis of the complete stereoisomer library of SCH725674 macrolactones. | Four mixtures of four fluorous-tagged quasiisomers have been synthesized, demixed, and detagged to make all 16 stereoisomers of the macrocyclic lactone natural product Sch725674. A new bare-minimum tagging pattern needs only two tags--one fluorous and one nonfluorous--to encode four isomers. The structure of Sch725674 ... | ['Antifungal Agents', 'Aspergillus', 'Halogenation', 'Lactones', 'Macrocyclic Compounds', 'Stereoisomerism'] | 22,515,682 | [['D27.505.954.122.136'], ['B01.300.381.081'], ['G02.111.323', 'G03.360'], ['D02.540'], ['D04.345'], ['G02.607.445.682']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The impact of endodontic irrigating solutions on the push-out shear bond strength of glass fiber posts luted with resin cements. | Resin-based restorative materials, widely used to cement posts, may be influenced by irrigants used during endodontic chemical-mechanical preparation. This study evaluated the impact of endodontic irrigating solutions and adhesive cement systems on the push-out shear bond strength of glass fiber posts to root dentin. N... | ['Animals', 'Cattle', 'Dental Bonding', 'Post and Core Technique', 'Resin Cements', 'Root Canal Irrigants', 'Root Canal Preparation', 'Shear Strength'] | 26,742,163 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['E06.095'], ['E06.780.346.250.500', 'E07.695.190.088.500'], ['D05.750.716.822.730', 'D25.339.291.750', 'D25.720.716.822.730', 'J01.637.051.339.291.750', 'J01.637.051.720.716.822.730'], ['D25.800', 'D27.505.954.122.425.300.500', 'D27.720.274.300.500', 'J01.637.051.... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
An antisense RNA in a lytic cyanophage links psbA to a gene encoding a homing endonuclease. | Cyanophage genomes frequently possess the psbA gene, encoding the D1 polypeptide of photosystem II. This protein is believed to maintain host photosynthetic capacity during infection and enhance phage fitness under high-light conditions. Although the first documented cyanophage-encoded psbA gene contained a group I int... | ['Amino Acid Sequence', 'Bacteriophages', 'Blotting, Northern', 'Computational Biology', 'Cyanobacteria', 'Endonucleases', 'Gene Expression Profiling', 'Introns', 'Metagenome', 'Molecular Sequence Data', 'Photosystem II Protein Complex', 'Phylogeny', 'RNA Splicing', 'RNA, Antisense', 'RNA, Messenger', 'RNA, Viral', 'Se... | 20,410,936 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B04.123'], ['E05.196.401.095', 'E05.301.300.074', 'E05.601.100'], ['H01.158.273.180', 'L01.313.124'], ['B03.280', 'B03.440.475.100'], ['D08.811.277.352.355'], ['E05.393.332'], ['G05.360.340.024.220.400', 'G05.360.340.024.340.137.515'], ['G05.360.340.550'], ['L01.453.245.66... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Establishment of the B cell precursor acute lymphoblastic leukemia cell line MUTZ-5 carrying a (12:13) translocation. | Continuous leukemia-lymphoma cell lines are important research tools, in particular as starting material for the cloning of recurrent translocations. In 1998, we established the continuous leukemia cell line MUTZ-5 and its two simultaneous sister cell lines MUTZ-6 and MUTZ-7. The primary specimen was obtained from the ... | ['Adult', 'B-Lymphocytes', 'Chromosomes, Human, Pair 12', 'Chromosomes, Human, Pair 13', 'DNA Fingerprinting', 'Humans', 'Karyotyping', 'Male', 'Precursor Cell Lymphoblastic Leukemia-Lymphoma', 'Translocation, Genetic', 'Tumor Cells, Cultured'] | 11,516,110 | [['M01.060.116'], ['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['A11.284.187.520.300.325.360', 'G05.360.162.520.300.325.360'], ['A11.284.187.520.300.370.375', 'G05.360.162.520.300.370.375'], ['E05.318.740.225.500.500', 'E05.393.290', 'I01.198.7... | ['Named Groups [M]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Endosonographic findings of gastric ectopic pancreas: a single center experience. | BACKGROUND AND AIM: Ectopic pancreas is a common submucosal lesion in the stomach, but its histological diagnosis is usually difficult when tissue samples are obtained with a conventional biopsy forceps. The aim of this study was to describe the endosonographic features of gastric ectopic pancreas.METHODS: We retrospec... | ['Adolescent', 'Adult', 'Aged', 'Biopsy', 'Chi-Square Distribution', 'Choristoma', 'Diagnosis, Differential', 'Endosonography', 'Female', 'Humans', 'Male', 'Middle Aged', 'Pancreas', 'Predictive Value of Tests', 'Republic of Korea', 'Retrospective Studies', 'Stomach Diseases', 'Stomach Neoplasms', 'Young Adult'] | 21,557,771 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['C23.300.250'], ['E01.171'... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Geographicals [Z]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Identification of a unique B-cell-stimulating factor produced by a cloned dendritic cell. | We describe a cloned dendritic cell, clone Den-1, which is a potent accessory cell for some B-cell responses. Clone Den-1 produces a unique lymphokine that induces polyclonal B-cell proliferation in the absence of other costimulators. This clone or factors produced by it also stimulate purified B cells to develop plaqu... | ['Animals', 'Antibody Formation', 'B-Lymphocytes', 'Cell Line', 'Growth Substances', 'Lymphocyte Activation', 'Lymphokines', 'Mice', 'Spleen'] | 3,871,522 | [['B01.050'], ['G12.450.050.370.250'], ['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['A11.251.210'], ['D27.505.696.377'], ['E01.370.225.812.482', 'E05.200.812.482', 'E05.478.594.530', 'G12.450.050.400.545', 'G12.565'], ['D12.644.276.374.480', '... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Elevated erythrocyte adenosine deaminase activity in patients with acquired immunodeficiency syndrome. | Acquired immunodeficiency syndrome (AIDS) is an often fatal disease caused by a retrovirus frequently resulting in malignancy and/or opportunistic infection. Because the immune deficiency in AIDS is similar to that in some purine enzyme deficiencies, we measured erythrocyte adenosine deaminase (ADA) and purine nucleosi... | ['Acquired Immunodeficiency Syndrome', 'Adenosine Deaminase', 'Antibodies, Viral', 'Deltaretrovirus', 'Erythrocytes', 'Humans', 'Lymphatic Diseases', 'Nucleoside Deaminases', 'Retroviridae Infections'] | 3,006,027 | [['C01.221.250.875.040', 'C01.221.812.640.400.040', 'C01.778.640.400.040', 'C01.925.782.815.616.400.040', 'C01.925.813.400.040', 'C01.925.839.040', 'C20.673.480.040'], ['D08.811.277.151.486.075'], ['D12.776.124.486.485.114.254', 'D12.776.124.790.651.114.254', 'D12.776.377.715.548.114.254'], ['B04.613.807.200', 'B04.820... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Prenatal ultrasound diagnosis of MYH7 non-compaction cardiomyopathy. | We report on two prenatal ultrasound diagnoses of left ventricular non-compaction cardiomyopathy (LVNC) associated with mutation of the cardiac â-myosin heavy chain gene (MYH7). LVNC is characterized by a trabecular meshwork and deep intertrabecular myocardial recesses communicating with the left ventricular cavity. Cl... | ['Cardiac Myosins', 'Child, Preschool', 'Female', 'Fetal Diseases', 'Genetic Predisposition to Disease', 'Heart Ventricles', 'Humans', 'Infant', 'Infant, Newborn', 'Isolated Noncompaction of the Ventricular Myocardium', 'Male', 'Mutation', 'Myosin Heavy Chains', 'Pregnancy', 'Prenatal Diagnosis', 'Treatment Outcome', '... | 22,859,017 | [['D05.750.078.730.475.475.124', 'D08.811.277.040.025.193.750.750.124', 'D12.776.210.500.600.470.249', 'D12.776.220.525.475.475.124'], ['M01.060.406.448'], ['C13.703.277', 'C16.300'], ['C23.550.291.687.500', 'G05.380.355'], ['A07.541.560'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Nucleosomes are phased along the mouse beta-major globin gene in erythroid and nonerythroid cells. | We have used the chemical cleavage reagent methidiumpropyl-EDTA-Fe(II) to determine the location of the nucleosomes along the mouse beta-major globin gene in erythroid and nonerythroid cells. In mouse L cells, in which the globin gene is inactive, the nucleosomes are precisely positioned with respect to the underlying ... | ['Animals', 'Edetic Acid', 'Erythrocytes', 'Fibroblasts', 'Gene Expression Regulation', 'Globins', 'Hematopoietic Stem Cells', 'Mice', 'Nucleosomes', 'Transcription, Genetic'] | 3,081,263 | [['B01.050'], ['D02.092.782.258.368.250', 'D02.241.081.018.253'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['A11.329.228'], ['G05.308'], ['D12.776.422.316'], ['A11.148.378', 'A11.872.378', 'A15.378.316.378'], ['B01.050.150.900.649.313.992.635.505.500'], ['A11.284.430.106.279.345.190.160.180.625', 'D12.776.664... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Adherence, invasion, toxigenic, and chemotactic properties of Mexican campylobacter strains. | To determine the virulence factors of Mexican wild-type strains of Campylobacter jejuni and Campylobacter coli, 31 wild-type strains were isolated from food and from humans. The production of cytolethal distending toxin and the adherence and invasion capabilities of these strains were assayed in Vero cells. Hard agar p... | ['Animals', 'Bacterial Adhesion', 'Campylobacter', 'Campylobacter coli', 'Campylobacter jejuni', 'Chlorocebus aethiops', 'Consumer Product Safety', 'Food Contamination', 'Food Microbiology', 'Humans', 'Mexico', 'Vero Cells', 'Virulence'] | 21,219,724 | [['B01.050'], ['G06.099.050'], ['B03.440.180', 'B03.660.150.235.250.500'], ['B03.440.180.200', 'B03.660.150.235.250.500.100'], ['B03.440.180.425', 'B03.660.150.235.250.500.375'], ['B01.050.150.900.649.313.988.400.112.199.120.126.110'], ['N06.850.210'], ['J01.576.423.850.730.500.249', 'N06.850.460.400', 'N06.850.601.500... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Disciplines and Occupations [H]', 'Geographicals [Z]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 |
The sequence and model structure analysis of three Polish peanut stunt virus strains. | Peanut stunt virus (PSV) belongs to the Cucumovirus genus of the family Bromoviridae and is widely distributed worldwide, also in Poland. PSV is a common pathogen of a wide range of economically important plants. Its coat protein (CP), similarly as in other viruses, plays an important role in many processes during vira... | ['Amino Acid Sequence', 'Arachis', 'Base Sequence', 'Capsid Proteins', 'Cucumovirus', 'Models, Biological', 'Models, Molecular', 'Molecular Sequence Data', 'Phylogeny', 'Plant Diseases', 'Plants', 'Poland', 'Sequence Alignment', 'Viral Proteins'] | 18,049,887 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.650.940.800.575.912.250.401.077'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D12.776.964.970.600.550'], ['B04.715.081.180', 'B04.715.464.180', 'B04.820.578.282.180'], ['E05.599.395'], ['E05.599.595'], ['L01.453.245.667'], ['G05.697', 'G16.075.605', '... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 |
Rapid short-term clearance of chrysotile compared with amosite asbestos in the guinea pig. | Compared with amphibole forms of asbestos, chrysotile asbestos fails to accumulate in lung tissue; the mechanism of this effect is disputed. To investigate this problem, we administered a mixture of the amphibole, amosite, and chrysotile to guinea pigs by intratracheal instillation. At 1 day, 1 week, and 1 month after ... | ['Animals', 'Asbestos', 'Asbestos, Amosite', 'Asbestos, Serpentine', 'Female', 'Guinea Pigs', 'Lung', 'Mucociliary Clearance', 'Time Factors'] | 2,539,032 | [['B01.050'], ['D01.578.725.050', 'D01.837.725.700.760.070'], ['D01.524.500.040', 'D01.578.725.050.050.050', 'D01.578.725.500.040', 'D01.837.725.700.760.070.050.060', 'D01.837.725.700.760.535.040'], ['D01.524.500.050', 'D01.578.725.050.075', 'D01.578.725.500.050', 'D01.837.725.700.760.070.110', 'D01.837.725.700.760.535... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Comparative sequence analysis reveals an intricate network among REST, CREB and miRNA in mediating neuronal gene expression. | BACKGROUND: Two distinct classes of regulators have been implicated in regulating neuronal gene expression and mediating neuronal identity: transcription factors such as REST/NRSF (RE1 silencing transcription factor) and CREB (cAMP response element-binding protein), and microRNAs (miRNAs). How these two classes of regu... | ['Cyclic AMP Response Element-Binding Protein', 'Gene Expression Regulation', 'Genome, Human', 'Humans', 'MicroRNAs', 'Nerve Tissue Proteins', 'Nervous System Physiological Phenomena', 'Repressor Proteins', 'Sequence Analysis', 'Transcription Factors'] | 17,002,790 | [['D12.776.260.108.184', 'D12.776.930.127.184'], ['G05.308'], ['G05.360.340.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D13.150.650.319', 'D13.444.735.150.319', 'D13.444.735.790.552.500'], ['D12.776.631'], ['G11.561'], ['D12.776.260.703', 'D12.776.930.780'], ['E05.393.760'], ['D12.776.930']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
GM1 up-regulates Ubiquilin 1 expression in human neuroblastoma cells and rat cortical neurons. | GM1 ganglioside was reported to mediate the amyloid beta-protein (Abeta) secretion and accumulation in the pathogenesis of Alzheimer's disease (AD). The objective of this project was to comprehend the underlying molecular changes related to amyloid beta-protein precursor (APP) processing pathway induced by GM1. Using s... | ['Adaptor Proteins, Signal Transducing', 'Amyloid beta-Protein Precursor', 'Analysis of Variance', 'Animals', 'Animals, Newborn', 'Autophagy-Related Proteins', 'Blotting, Western', 'Carrier Proteins', 'Cell Cycle Proteins', 'Cells, Cultured', 'Cerebral Cortex', 'Dose-Response Relationship, Drug', 'G(M1) Ganglioside', '... | 16,949,204 | [['D12.644.360.024', 'D12.776.157.057', 'D12.776.476.024'], ['D12.776.049.407.249', 'D12.776.543.039', 'D12.776.645.468.500', 'D12.776.811.050'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['B01.050'], ['B01.050.050.282'], ['D12.776.094'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Cobalt blocks postsynaptic responses induced by neurotransmitters in the hippocampus in vitro. | Divalent metals such as cobalt are frequently used by neurophysiologists to prevent synaptic transmission, because they are thought to selectively block presynaptic calcium conductance. Recording intracellularly from hippocampal CA3 pyramidal cells we show that Co2+ (2 mM) is not specific in this action but also dimini... | ['Animals', 'Artifacts', 'Calcium Channels', 'Cobalt', 'Hippocampus', 'Ion Channel Gating', 'Neurotransmitter Agents', 'Rats', 'Rats, Inbred Strains', 'Receptors, GABA-A', 'Receptors, Glutamate', 'Receptors, N-Methyl-D-Aspartate', 'Receptors, Neurotransmitter', 'Receptors, Purinergic', 'Synapses', 'Synaptic Transmissio... | 1,687,700 | [['B01.050'], ['E05.047'], ['D12.776.157.530.400.150', 'D12.776.543.550.450.150', 'D12.776.543.585.400.150'], ['D01.268.556.185', 'D01.268.956.155', 'D01.552.544.185'], ['A08.186.211.180.405', 'A08.186.211.200.885.287.500.345'], ['G02.111.820.400', 'G04.835.400', 'G07.265.625'], ['D27.505.519.625', 'D27.505.696.577'], ... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Age differences in the maintenance and restructuring of movement preparation. | In 2 experiments, elderly and young subjects performed simple reaction time, choice reaction time, and movement plan restructuring tasks, using a stimulus precuing paradigm. In Experiment 1, the precue display (200 ms) and preparation interval (250, 500, 750, or 1,000 ms) were experimentally determined. In Experiment 2... | ['Adult', 'Aged', 'Aging', 'Attention', 'Cues', 'Female', 'Humans', 'Kinesthesis', 'Male', 'Orientation', 'Pattern Recognition, Visual', 'Psychomotor Performance', 'Reaction Time'] | 1,930,762 | [['M01.060.116'], ['M01.060.116.100'], ['G07.345.124'], ['F02.830.104.214'], ['F02.463.425.234'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.830.816.541.504', 'G11.561.790.541.587'], ['F01.058.577', 'F02.830.606'], ['F02.463.593.524.500', 'F02.463.593.932.622'], ['F02.808', 'G11.427.700', 'G11.561.660'], ['... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Biochemical effect of antioxidants on lipids and liver function in experimentally-induced liver damage. | Recent studies demonstrated the role of antioxidants in preventing organ damage caused by free radicals. The present study was conducted to find out the modulatory effect of some antioxidants on lipid patterns in experimentally-induced liver damage. Rats chronically intoxicated with carbon tetrachloride (CCl4) were use... | ['Animals', 'Antioxidants', 'Carbon Tetrachloride Poisoning', 'Lipid Metabolism', 'Lipids', 'Liver', 'Liver Cirrhosis, Experimental', 'Liver Function Tests', 'Male', 'Necrosis', 'Rats'] | 9,367,004 | [['B01.050'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['C25.723.177'], ['G03.458'], ['D10'], ['A03.620'], ['C06.552.630.467', 'C23.550.355.412.467', 'E05.598.500.468'], ['E01.370.372.460'], ['C23.550.717'], ['B01.050.150.900.649.313.992.635.505.700']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Approaches to risk assessment in food allergy: report from a workshop ''developing a framework for assessing the risk from allergenic foods". | A workshop was organised to investigate whether risk assessment strategies and methodologies used in classical/conventional toxicology may be used for risk assessment of allergenic foods, to discuss the advantages and limitations of different approaches and to determine the research needed to move the area forward. Thr... | ['Animals', 'Disease Models, Animal', 'Food', 'Food Hypersensitivity', 'Food Supply', 'Humans', 'Plant Proteins', 'Risk Assessment', 'Toxicity Tests'] | 19,101,602 | [['B01.050'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['G07.203.300', 'J02.500'], ['C20.543.480.370'], ['J01.576.423.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.765'], ['E05.318.740.600.800.715', 'N04.452.871.715', 'N05.715.360.750.625.700.690', 'N06.850.505.715', 'N06.850.520.830.600.800.7... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Limb gangrene secondary to thromboembolic disease of the newborn. | Thromboembolic disease of the newborn is a well-known entity to neonatologists. When severe arterial compromise threatens limb survival, the orthopaedic surgeon may be called on to assist in the management of this disorder. A case of spontaneous postnatal ischemic gangrene of an upper extremity that resulted in amputat... | ['Arm', 'Cellulitis', 'Female', 'Gangrene', 'Humans', 'Infant, Newborn', 'Skin', 'Skin Diseases', 'Thromboembolism'] | 1,565,512 | [['A01.378.800.075'], ['C01.800.130', 'C01.830.200', 'C17.300.185', 'C23.550.470.756.200'], ['C23.550.717.427'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['A17.815'], ['C17.800'], ['C14.907.355.590']] | ['Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Trehalose phosphate synthase overexpression in Parachlorella kessleri improves growth and photosynthetic performance under high light conditions. | Parachlorella kessleri is a promising oil-bearing marine alga which shows decreased growth under high light stress. Osmolytes are known to relieve stress by protecting the cell membrane, proteins, and enzymes. Enhanced production of osmolyte (trehalose) was thus used to relieve stress in P. kessleri by overexpression o... | ['Biofuels', 'Biomass', 'Chlorophyta', 'Gene Transfer Techniques', 'Glucosyltransferases', 'Light', 'Lipid Peroxidation', 'Photosynthesis', 'Plant Proteins', 'Trehalose', 'Up-Regulation'] | 26,829,380 | [['D20.147', 'N06.230.132.644.124'], ['G16.500.275.157.100', 'N06.230.124.100'], ['B01.650.940.150'], ['E05.393.350'], ['D08.811.913.400.450.460'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['G02.111.515', 'G03.295.531.587'], ['G02.111.158.937', 'G02.111.669.700', 'G02.740.921', 'G03... | ['Chemicals and Drugs [D]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Identification and characterization of rns4/vps32 mutation in the RNase T1 expression-sensitive strain of Saccharomyces cerevisiae: Evidence for altered ambient response resulting in transportation of the secretory protein to vacuoles. | We previously reported a genetic analysis of the growth-inhibitory effect caused by the overexpression of the Aspergillus oryzae rntA gene, encoding RNase T1 (Ribonuclease T1), in Saccharomyces cerevisiae. Subsequently, rns (ribonuclease T1 sensitive) mutants with mutations in the rns1 (DSL1), rns2 (UMP1), and rns3 (SE... | ['Biological Transport', 'Endoplasmic Reticulum', 'Endosomal Sorting Complexes Required for Transport', 'Gene Expression Regulation, Fungal', 'Genetic Complementation Test', 'Genome, Fungal', 'Microscopy, Fluorescence', 'Mutagenesis, Insertional', 'Nuclear Proteins', 'Oligonucleotide Array Sequence Analysis', 'Plasmids... | 15,925,308 | [['G03.143'], ['A11.284.430.214.190.875.248'], ['D05.500.199', 'D12.776.543.990.493'], ['G05.308.330'], ['E05.393.281.526'], ['G05.360.340.358.365'], ['E01.370.350.515.458', 'E05.595.458'], ['E05.393.420.601.550', 'G05.365.590.575', 'G05.558.550'], ['D12.776.660'], ['E05.393.661.640', 'E05.393.760.640', 'E05.588.570.66... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
groEL is a suitable genetic marker for detecting Vibrio parahaemolyticus by loop-mediated isothermal amplification assay. | A groEL gene-based loop-mediated isothermal amplification (LAMP) assay was developed to detect Vibrio parahaemolyticus in contaminated seafood and water. The assay was optimized and conducted at 63°C for 40 min using Bacillus stearothermophilus (Bst) DNA polymerase, large fragment. Amplification was analysed via multip... | ['Bacterial Proteins', 'Chaperonin 60', 'Foodborne Diseases', 'Genetic Markers', 'Limit of Detection', 'Nucleic Acid Amplification Techniques', 'Reproducibility of Results', 'Seafood', 'Sensitivity and Specificity', 'Species Specificity', 'Vibrio parahaemolyticus'] | 28,585,379 | [['D12.776.097'], ['D08.811.277.040.025.142.500.500', 'D12.776.580.216.210.590.750'], ['C25.723.415'], ['D23.101.387', 'G05.695.450'], ['E05.318.740.872.374', 'N05.715.360.750.725.500', 'N06.850.520.830.872.500'], ['E05.393.620'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['G07.2... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Glucocorticoids inhibit cytokine-mediated eosinophil survival. | Glucocorticoids characteristically induce eosinopenia in vivo and are effective for treating allergic and other eosinophilic disorders. We studied the effect of glucocorticoids on cytokine-induced survival of human eosinophils in vitro. Eosinophils were purified from normal or mildly atopic volunteers by Percoll densit... | ['Cell Survival', 'Cytokines', 'Dexamethasone', 'Eosinophils', 'Glucocorticoids', 'Granulocyte-Macrophage Colony-Stimulating Factor', 'Humans', 'Hydrocortisone', 'In Vitro Techniques', 'Interferon-gamma', 'Interleukin-3', 'Interleukin-5', 'Methylprednisolone'] | 1,940,348 | [['G04.346'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['D04.210.500.745.432.769.344', 'D04.210.500.908.238'], ['A11.118.637.415.345', 'A11.627.340.345', 'A15.145.229.637.415.345', 'A15.382.490.315.251'], ['D06.472.040.543', 'D27.505.696.399.472.488'], ['D12.644.276.374.410.240.375', 'D12.776.395.240.300'... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effectiveness of mindfulness-based cognitive therapy for co-morbid depression in drug-dependent males. | The present study aimed at examining the effect of Mindfulness-Based Cognitive Therapy (MBCT) in decreasing depression symptoms in dully diagnosed males (drug dependent males with co-morbid depression).An experimental research design with pre- and post-tests and a control group was used. The sample of the study compris... | ['Adolescent', 'Adult', 'Depression', 'Humans', 'Male', 'Mindfulness', 'Psychiatric Status Rating Scales', 'Substance-Related Disorders', 'Treatment Outcome', 'Young Adult'] | 25,439,972 | [['M01.060.057'], ['M01.060.116'], ['F01.145.126.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.551', 'F04.754.137.350.500'], ['F04.711.513.653'], ['C25.775', 'F03.900'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800'], ['M01.060.116.815']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Directed evolution of Bacillus subtilis lipase A by use of enantiomeric phosphonate inhibitors: crystal structures and phage display selection. | Phage display can be used as a protein-engineering tool for the selection of proteins with desirable binding properties from a library of mutants. Here we describe the application of this method for the directed evolution of Bacillus subtilis lipase A, an enzyme that has important properties for the preparation of the ... | ['Bacillus subtilis', 'Bacterial Proteins', 'Cloning, Molecular', 'Crystallization', 'Crystallography, X-Ray', 'Directed Molecular Evolution', 'Enzyme Inhibitors', 'Hydrolysis', 'Models, Molecular', 'Molecular Structure', 'Mutation', 'Peptide Library', 'Phosphates', 'Protein Conformation', 'Protein Structure, Tertiary'... | 16,342,303 | [['B03.300.390.400.158.218.725', 'B03.353.500.100.218.725', 'B03.510.100.100.218.725', 'B03.510.415.400.158.218.725', 'B03.510.460.410.158.218.725'], ['D12.776.097'], ['E05.393.220'], ['E05.196.300', 'G02.171'], ['E05.196.309.742.225'], ['E05.393.420.175'], ['D27.505.519.389'], ['G02.380'], ['E05.599.595'], ['G02.111.5... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Further evidence for an association between a mutation in the APP gene and Lewy body formation. | There have been two detailed neuropathological reports of families with a valine to isoleucine substitution at position 717 of the amyloid precursor protein gene. Surprisingly, in one of these families substantial Lewy body formation occurred in addition to Alzheimer's disease, prompting the speculation that such a gen... | ['Alzheimer Disease', 'Amyloid beta-Protein Precursor', 'Brain', 'Chromosomes, Human, Pair 21', 'Female', 'Humans', 'Isoleucine', 'Lewy Bodies', 'Middle Aged', 'Point Mutation'] | 9,178,856 | [['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['D12.776.049.407.249', 'D12.776.543.039', 'D12.776.645.468.500', 'D12.776.811.050'], ['A08.186.211'], ['A11.284.187.520.300.505.510', 'G05.360.162.520.300.505.510'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.125.070.577', 'D12.125.142.383'], ... | ['Diseases [C]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Named Groups [M]'] | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[MiR-24 improves beta-like globin gene expression through targeting Sp1]. | We studied the function and mechanism of miR-24 in regulating beta-like globin gene expression. We first detected the expression of miR-24 during erythroid differentiation and also detected the globin gene expression in miR-24 overexpressing K562 cells through q-PCR. Dual-luciferase reporter assay and Western blotting ... | ['Cell Differentiation', 'Gene Expression Regulation', 'Hematopoietic Stem Cells', 'Humans', 'K562 Cells', 'MicroRNAs', 'Sp1 Transcription Factor', 'epsilon-Globins', 'gamma-Globins'] | 24,195,361 | [['G04.152'], ['G05.308'], ['A11.148.378', 'A11.872.378', 'A15.378.316.378'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.251.210.190.510', 'A11.251.860.180.510', 'A11.443.240.497.480'], ['D13.150.650.319', 'D13.444.735.150.319', 'D13.444.735.790.552.500'], ['D12.776.260.522.750.249', 'D12.776.930.375.750.24... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Characterization of the receptor for insulin-like growth factor II in bone cells. | We have previously shown that insulin-like growth factor II (IGF-II) is produced by bone cells and that IGF-II stimulates cell proliferation and collagen synthesis in bone cells. We now extend these in vitro findings by demonstrating specific IGF-II binding to bone cells derived from newborn mouse calvaria and embryoni... | ['Animals', 'Binding, Competitive', 'Bone and Bones', 'Cell Division', 'Cells, Cultured', 'Chick Embryo', 'Mice', 'Mice, Inbred Strains', 'Osteoblasts', 'Receptors, Cell Surface', 'Receptors, Somatomedin', 'Recombinant Proteins', 'Temperature', 'Time Factors'] | 2,544,614 | [['B01.050'], ['E05.196.080', 'G02.111.084', 'G02.111.570.120.309'], ['A02.835.232', 'A10.165.265'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.251'], ['A13.350.150', 'A16.331.200'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520', 'B01.050.150.900.649.313.99... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Hemodynamic characteristics of Edwards Sapien aortic valve prosthesis assessed with transesophageal echocardiography. | BACKGROUND AND AIM OF THE STUDY: Transcatheter aortic valve implantation (TAVI) has become the therapy of choice in high-risk patients with aortic stenosis. Transesophageal echocardiography provides important anatomic and functional information before, during, and after any procedure. The study aim was to determine the... | ['Aortic Valve', 'Echocardiography', 'Heart Valve Prosthesis', 'Hemodynamics', 'Humans', 'Reference Values'] | 23,167,233 | [['A07.541.510.110'], ['E01.370.350.130.750', 'E01.370.350.850.220', 'E01.370.370.380.220'], ['E07.695.310'], ['G09.330.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.978.810']] | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Severe colitis after PD-1 blockade with nivolumab in advanced melanoma patients: potential role of Th1-dominant immune response in immune-related adverse events: two case reports. | BACKGROUND: Nivolumab is an immune checkpoint inhibitor specific to the programmed death 1 (PD-1) receptor. Nivolumab has shown clinical responses in many malignancies. Although immune-related adverse events (irAEs) associated with nivolumab are largely tolerable, severe irAEs have occurred in some patients. However, t... | ['Aged, 80 and over', 'Antineoplastic Agents, Immunological', 'Biomarkers, Tumor', 'C-Reactive Protein', 'CD8-Positive T-Lymphocytes', 'Colitis', 'Fatal Outcome', 'Follow-Up Studies', 'Humans', 'Interleukin-6', 'Lymphocytes, Tumor-Infiltrating', 'Male', 'Melanoma', 'Middle Aged', 'Nivolumab', 'Programmed Cell Death 1 R... | 31,664,934 | [['M01.060.116.100.080'], ['D27.505.954.248.384'], ['D23.101.140'], ['D12.776.034.145', 'D12.776.124.050.120', 'D12.776.124.486.157'], ['A11.118.637.555.567.569.220', 'A15.145.229.637.555.567.569.220', 'A15.382.490.555.567.569.220'], ['C06.405.205.265', 'C06.405.469.158.188'], ['E05.318.308.985.550.325', 'N01.224.935.6... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Quality of life and a symptom cluster associated with breast cancer treatment-related lymphedema. | OBJECTIVES: The aim of this study was to compare quality of life and symptoms between breast cancer survivors who have developed and undergone treatment for chronic lymphedema with those who have not developed lymphedema.PATIENTS AND METHODS: The cross-sectional, mixed-methods design included 64 breast cancer survivors... | ['Breast Neoplasms', 'Chronic Disease', 'Cross-Sectional Studies', 'Female', 'Humans', 'Lymphedema', 'Quality of Life', 'Sickness Impact Profile', 'Survivors'] | 15,812,652 | [['C04.588.180', 'C17.800.090.500'], ['C23.550.291.500'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C15.604.496'], ['I01.800', 'K01.752.400.750', 'N06.850.505.400.425.837'], ['E05.318.308.980.438.475.730', 'N05.715.360.300.800.438.3... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Specific membrane binding of the carboxypeptidase Y inhibitor I(C), a phosphatidylethanolamine-binding protein family member. | I(C), an endogenous cytoplasmic inhibitor of vacuolar carboxypeptidase Y in the yeast Saccharomyces cerevisiae, is classified as a member of the phosphatidylethanolamine-binding protein family. The binding of I(C) to phospholipid membranes was first analyzed using a liposome-binding assay and by surface plasmon resonan... | ['Binding Sites', 'Carrier Proteins', 'Cell Membrane', 'Green Fluorescent Proteins', 'Microscopy, Fluorescence', 'Phosphatidylethanolamine Binding Protein', 'Phosphatidylethanolamines', 'Phospholipids', 'Protein Conformation', 'Saccharomyces cerevisiae', 'Saccharomyces cerevisiae Proteins', 'Surface Plasmon Resonance'] | 17,076,703 | [['G02.111.570.120'], ['D12.776.157'], ['A11.284.149'], ['D12.776.532.265'], ['E01.370.350.515.458', 'E05.595.458'], ['D12.644.360.562', 'D12.776.157.661', 'D12.776.476.555'], ['D10.570.755.375.760.400.840'], ['D10.570.755'], ['G02.111.570.820.709'], ['B01.300.107.795.785.800', 'B01.300.930.705.655'], ['D12.776.354.750... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Rapid detection of the Chlamydiaceae and other families in the order Chlamydiales: three PCR tests. | Few identification methods will rapidly or specifically detect all bacteria in the order Chlamydiales, family Chlamydiaceae. In this study, three PCR tests based on sequence data from over 48 chlamydial strains were developed for identification of these bacteria. Two tests exclusively recognized the Chlamydiaceae: a mu... | ['Bacterial Outer Membrane Proteins', 'Chlamydiaceae', 'Chlamydiaceae Infections', 'Chlamydiales', 'DNA Primers', 'DNA, Ribosomal', 'Gram-Negative Bacterial Infections', 'Humans', 'Introns', 'Polymerase Chain Reaction', 'RNA, Bacterial', 'RNA, Ribosomal, 23S', 'Sensitivity and Specificity'] | 9,986,815 | [['D12.776.097.120', 'D12.776.543.100'], ['B03.440.190.190'], ['C01.150.252.400.210'], ['B03.440.190'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['D13.444.308.475'], ['C01.150.252.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G05.360.340.024.220.400', 'G05.360.340.024.340.137.515'], ['E05... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Ambient air pollution, smog episodes and mortality in Jinan, China. | We aimed to assess the acute effects of ambient air pollution and weather conditions on mortality in the context of Chinese smog episodes. A total of 209,321 deaths were recorded in Jinan, a large city in eastern China, during 2011-15. The mean concentrations of daily particulate matter ?10 ìm (PM10), fine particulate ... | ['Age Distribution', 'Air Pollution', 'China', 'Female', 'Humans', 'Male', 'Mortality', 'Risk Assessment', 'Seasons', 'Sex Distribution', 'Smog', 'Survival Analysis', 'Weather'] | 28,894,179 | [['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['N06.850.460.100'], ['Z01.252.474.164'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.550', 'N01.224.935.698', 'N06.850.505.400.975.550', 'N06.850.520.308.985.550'], ['E05.318.740.600.800.715', 'N04.452.871.715', 'N05.715.360.750.625.700.690... | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Geographicals [Z]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Comparative study of glucosidases from the thermophilic fungus Thermoascus aurantiacus Miehe. Purification and characterization of intracellular beta-glucosidase. | Intracellular beta-glucosidase was extracted from the mycelium of Th. aurantiacus, concentrated by DEAE-cellulose treatment, separated from alpha-glucosidase by hydroxylapatite chromatography and purified to electrophoretic homogeneity. Optimally active at 75 degrees C and pH 4.2, beta-glucosidase displayed complex kin... | ['Amino Acids', 'Ascomycota', 'Carbohydrates', 'Catalysis', 'Chromatography', 'Chromatography, Gel', 'Electrophoresis, Polyacrylamide Gel', 'Glucosidases', 'Glycoproteins', 'Hydrogen-Ion Concentration', 'Isoelectric Point', 'Kinetics', 'Molecular Weight', 'Temperature', 'alpha-Glucosidases', 'beta-Glucosidase'] | 3,935,599 | [['D12.125'], ['B01.300.107'], ['D09'], ['G02.130'], ['E05.196.181'], ['E05.196.181.400.250'], ['E05.196.401.402', 'E05.301.300.319'], ['D08.811.277.450.420'], ['D09.400.430', 'D12.776.395'], ['G02.300'], ['E05.301.300.663.500', 'G02.300.500'], ['G01.374.661', 'G02.111.490'], ['G02.494'], ['G01.906.595', 'G16.500.275.0... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Trypsin increases pseudorabies virus production through activation of the ERK signalling pathway. | Extracellular proteases that are expressed in primary and secondary foci of viral infection are potentially important mediators of infectious inflammatory processes. For some viruses, such as influenza virus and rotaviruses, proteases such as trypsin enhance infectivity by a direct proteolytic effect on some virion pro... | ['Animals', 'Cattle', 'Cell Line', 'Herpesvirus 1, Suid', 'Mitogen-Activated Protein Kinase 1', 'Mitogen-Activated Protein Kinase 3', 'Pseudorabies', 'Swine', 'Trypsin', 'Virus Replication'] | 16,603,510 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['A11.251.210'], ['B04.280.382.100.900.510'], ['D08.811.913.696.620.682.700.567.249.500', 'D12.644.360.450.169.500', 'D12.776.476.450.169.500'], ['D08.811.913.696.620.682.700.567.249.750', 'D12.644.360.450.169.750', 'D12.776.476.450.169.750'], ['C01.207.245.710', '... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Evaluation of the Etest and disk diffusion methods for determining susceptibilities of 235 bloodstream isolates of Candida glabrata to fluconazole and voriconazole. | The performances of the Etest and the disk diffusion methods for testing of the susceptibilities of 235 Candida glabrata isolates to fluconazole and voriconazole were compared with that of the National Committee for Clinical Laboratory Standards (NCCLS) approved standard broth microdilution (BMD) method. The NCCLS meth... | ['Agar', 'Antifungal Agents', 'Candida glabrata', 'Candidiasis', 'Culture Media', 'Fluconazole', 'Fungemia', 'Humans', 'Microbial Sensitivity Tests', 'Pyrimidines', 'Quality Control', 'Triazoles', 'Voriconazole'] | 12,734,220 | [['D09.698.360.041'], ['D27.505.954.122.136'], ['B01.300.107.795.095.400', 'B01.300.381.147.400', 'B01.300.930.176.400'], ['C01.150.703.160'], ['D27.720.470.305', 'E07.206'], ['D03.383.129.799.450'], ['C01.150.703.492.594', 'C01.757.360', 'C23.550.470.790.500.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E0... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Constitutive overexpression of human erythropoietin protects the mouse retina against induced but not inherited retinal degeneration. | Elevation of erythropoietin (Epo) concentrations by hypoxic preconditioning or application of recombinant human Epo (huEpo) protects the mouse retina against light-induced degeneration by inhibiting photoreceptor cell apoptosis. Because photoreceptor apoptosis is also the common path to cell loss in retinal dystrophies... | ['Animals', 'Apoptosis', 'Erythropoietin', 'Humans', 'Immunohistochemistry', 'Light', 'Mice', 'Mice, Transgenic', 'Mutation', 'Phosphoric Diester Hydrolases', 'Photoreceptor Cells', 'Protein Subunits', 'Recombinant Proteins', 'Retina', 'Retinal Degeneration', 'Rhodopsin'] | 15,215,287 | [['B01.050'], ['G04.146.954.035'], ['D12.644.276.374.410.240.150', 'D12.776.395.240.150', 'D12.776.467.374.410.240.150', 'D23.529.374.410.240.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.1... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Polyol-enhanced dispersive liquid-liquid microextraction coupled with gas chromatography and nitrogen phosphorous detection for the determination of organophosphorus pesticides from aqueous samples, fruit juices, and vegetables. | Polyol-enhanced dispersive liquid-liquid microextraction has been proposed for the extraction and preconcentration of some organophosphorus pesticides from different samples. In the present study, a high volume of an aqueous phase containing a polyol (sorbitol) is prepared and then a disperser solvent along with an ext... | ['Chemistry Techniques, Analytical', 'Chromatography, Gas', 'Food Analysis', 'Fruit and Vegetable Juices', 'Limit of Detection', 'Liquid Phase Microextraction', 'Nitrogen', 'Organophosphorus Compounds', 'Pesticides', 'Phosphorus', 'Vegetables', 'Water'] | 26,420,025 | [['E05.196'], ['E05.196.181.349'], ['E05.362', 'J01.576.423.850.100'], ['G07.203.100.606', 'J02.200.606'], ['E05.318.740.872.374', 'N05.715.360.750.725.500', 'N06.850.520.830.872.500'], ['E05.196.155.650.500'], ['D01.268.604', 'D01.362.625'], ['D02.705'], ['D27.720.031.700', 'D27.888.723'], ['D01.268.666'], ['B01.650.1... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Stepped-Wedge Cluster Randomized Controlled Trial to Promote Option B+ Retention in Central Mozambique. | BACKGROUND: This randomized trial studied performance of Option B+ in Mozambique and evaluated an enhanced retention package in public clinics.SETTING: The study was conducted at 6 clinics in Manica and Sofala Provinces in central Mozambique.METHODS: Seven hundred sixty-one pregnant women tested HIV+, immediately initi... | ['Adult', 'Anti-HIV Agents', 'CD4 Lymphocyte Count', 'Delivery of Health Care', 'Female', 'HIV Infections', 'Humans', 'Infectious Disease Transmission, Vertical', 'Medication Adherence', 'Middle Aged', 'Mozambique', 'Patient Acceptance of Health Care', 'Pregnancy', 'Pregnancy Complications, Infectious', 'Young Adult'] | 28,777,263 | [['M01.060.116'], ['D27.505.954.122.388.077.088'], ['E01.370.225.500.195.107.595.500.150', 'E01.370.225.625.107.595.500.150', 'E05.200.500.195.107.595.500.150', 'E05.200.625.107.595.500.150', 'E05.242.195.107.595.500.150', 'G04.140.107.595.500.150', 'G09.188.105.595.500.150'], ['N04.590.374', 'N05.300'], ['C01.221.250.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Activating oxidative phosphorylation by a pyruvate dehydrogenase kinase inhibitor overcomes sorafenib resistance of hepatocellular carcinoma. | BACKGROUND: Sorafenib is the only drug approved for the treatment of hepatocellular carcinoma (HCC). The bioenergetic propensity of cancer cells has been correlated to anticancer drug resistance, but such correlation is unclear in sorafenib resistance of HCC.METHODS: Six sorafenib-naive HCC cell lines and one sorafenib... | ['Animals', 'Apoptosis', 'Carcinoma, Hepatocellular', 'Cell Line, Tumor', 'Drug Resistance, Neoplasm', 'Glycolysis', 'Humans', 'Liver Neoplasms', 'Mice', 'Niacinamide', 'Oxidative Phosphorylation', 'Phenylurea Compounds', 'Protein-Serine-Threonine Kinases', 'Pyruvate Dehydrogenase Acetyl-Transferring Kinase', 'Sorafeni... | 23,257,894 | [['B01.050'], ['G04.146.954.035'], ['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['A11.251.210.190', 'A11.251.860.180'], ['G07.690.773.984.395'], ['G02.111.158.750', 'G03.191.750', 'G03.295.436', 'G03.493.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.274.6... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Carrier-mediated mechanism for the biliary excretion of the quinolone antibiotic grepafloxacin and its glucuronide in rats. | Grepafloxacin (GPFX) has a comparatively greater hepatobiliary transport than other quinolone antibiotics. The biliary excretion mechanism of GPFX was investigated in a series of in vivo and in vitro studies with Sprague-Dawley rats and the mutant strain Eisai-hyperbilirubinemia rats (EHBR), which have a hereditary def... | ['Animals', 'Anti-Infective Agents', 'Bile', 'Biological Transport, Active', 'Fluoroquinolones', 'Glucuronates', 'Glutathione', 'Hyperbilirubinemia', 'Male', 'Piperazines', 'Quinolones', 'Rats', 'Rats, Mutant Strains', 'Rats, Sprague-Dawley'] | 9,495,864 | [['B01.050'], ['D27.505.954.122'], ['A12.200.087'], ['G03.143.310'], ['D03.633.100.810.835.322'], ['D02.241.081.844.915.162', 'D02.241.152.811.162', 'D02.241.511.902.915.162', 'D09.811.922.162'], ['D12.644.456.448'], ['C23.550.429'], ['D03.383.606'], ['D03.633.100.810.835'], ['B01.050.150.900.649.313.992.635.505.700'],... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Sustainable urban water systems in rich and poor cities--steps towards a new approach. | The 'big pipes in, big pipes out' approach to urban water management was developed in the 19th century for a particular linear urban form. Large, sprawling car-dependent cities are pushing this approach to new limits in rich cities and it has never worked in poor cities. An alternative which uses new small-scale techno... | ['Conservation of Natural Resources', 'Global Health', 'Humans', 'Indonesia', 'New South Wales', 'Poverty', 'Residence Characteristics', 'Urbanization', 'Water Supply'] | 11,379,232 | [['J01.256', 'N06.230.080'], ['H02.403.371', 'N01.400.337'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.145.380', 'Z01.639.580'], ['Z01.639.100.750', 'Z01.678.100.373.750'], ['I01.880.735.634', 'I01.880.853.996.535', 'N01.824.600'], ['N01.224.791', 'N06.850.505.400.800'], ['I01.880.853.400.726'], ['J01.... | ['Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 1 |
Upper gastrointestinal bleeding associated with biliary diversion. | Significant upper gastrointestinal bleeding following operation was noted in 14 of 218 patients undergoing external biliary drainage. None of these patients sustained hepatic injury or needed hepatic resection. Three patients died from causes related to the upper gastrointestinal hemorrhage, and in 12 of the 14 patient... | ['Adult', 'Biliary Tract Diseases', 'Cholecystectomy', 'Common Bile Duct', 'Drainage', 'Duodenal Ulcer', 'Esophagitis', 'Female', 'Gastrointestinal Hemorrhage', 'Humans', 'Male', 'Peptic Ulcer Hemorrhage', 'Postoperative Complications', 'Sepsis'] | 1,083,703 | [['M01.060.116'], ['C06.130'], ['E04.210.120.172'], ['A03.159.183.079.300'], ['E02.309', 'E04.237'], ['C06.405.469.275.800.348', 'C06.405.748.586.349'], ['C06.405.117.620', 'C06.405.205.663'], ['C06.405.227', 'C23.550.414.788'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C06.405.227.700', 'C23.550.414.788.700']... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Exploiting the kernel trick to correlate fragment ions for peptide identification via tandem mass spectrometry. | MOTIVATION: The correlation among fragment ions in a tandem mass spectrum is crucial in reducing stochastic mismatches for peptide identification by database searching. Until now, an efficient scoring algorithm that considers the correlative information in a tunable and comprehensive manner has been lacking.RESULTS: Th... | ['Algorithms', 'Ions', 'Mass Spectrometry', 'Models, Chemical', 'Models, Molecular', 'Models, Statistical', 'Peptide Fragments', 'Peptides', 'Sequence Alignment', 'Sequence Analysis, Protein', 'Software', 'Statistics as Topic'] | 15,044,235 | [['G17.035', 'L01.224.050'], ['D01.248.497'], ['E05.196.566'], ['E05.599.495'], ['E05.599.595'], ['E05.318.740.500', 'E05.599.835', 'N05.715.360.750.530', 'N06.850.520.830.500'], ['D12.644.541'], ['D12.644'], ['E05.393.751'], ['E05.393.760.705'], ['L01.224.900'], ['E05.318.740', 'H01.548.832', 'N05.715.360.750', 'N06.8... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Sortal concepts and causal continuity: comment of Rips, Blok, and Newman (2006). | L. J. Rips, S. Blok, and G. Newman (2006) proposed that singular concepts, which support the tracing of individual objects across their existence, are governed by a principle of causal continuity. They purported to show that causal continuity is better than existing theories at explaining judgments of the persistence o... | ['Cognition', 'Humans', 'Judgment', 'Models, Psychological', 'Social Identification'] | 17,907,874 | [['F02.463.188'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.785.626'], ['E05.599.695'], ['F01.145.813.708']] | ['Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Homogeneous Escherichia coli FPG protein. A DNA glycosylase which excises imidazole ring-opened purines and nicks DNA at apurinic/apyrimidinic sites. | The repair of 2,6-diamino-4-hydroxy-5-N-methyl-formamidopyrimidine (Fapy) residues in DNA is performed by a Fapy-DNA glycosylase activity which is encoded for by the fpg gene in Escherichia coli. Besides DNA glycosylase activity, this protein, the FPG protein, is endowed with an EDTA-resistant activity nicking DNA at a... | ['Amino Acid Sequence', 'Bacterial Proteins', 'Base Sequence', 'DNA-(Apurinic or Apyrimidinic Site) Lyase', 'DNA-Formamidopyrimidine Glycosylase', 'Deoxyribonuclease IV (Phage T4-Induced)', 'Endodeoxyribonucleases', 'Escherichia coli', 'Escherichia coli Proteins', 'Genes, Bacterial', 'Kinetics', 'Molecular Sequence Dat... | 1,689,309 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D12.776.097'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D08.811.074.750', 'D08.811.520.241.225'], ['D08.811.074.249.500', 'D08.811.277.450.430.099.500'], ['D08.811.277.352.335.350.275'], ['D08.811.277.352.335.350', 'D08.811.277.352.355.325'], ['B03.440.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Eprosartan for the treatment of hypertension. | Antihypertensive agents are proven to reduce the cardiovascular risk of stroke, coronary heart disease and cardiac failure. The ideal antihypertensive agent should control all grades of hypertension and have a placebo-like side effect profile. Angiotensin II (AII) receptor antagonists are a relatively new class of anti... | ['Acrylates', 'Administration, Oral', 'Angiotensin II Type 1 Receptor Blockers', 'Female', 'Humans', 'Hypertension', 'Imidazoles', 'Male', 'Receptor, Angiotensin, Type 1', 'Spain', 'Thiophenes'] | 12,517,247 | [['D02.241.081.069'], ['E02.319.267.100'], ['D27.505.519.162.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['D03.383.129.308'], ['D12.776.543.750.695.047.625', 'D12.776.543.750.750.130.750'], ['Z01.542.846'], ['D02.886.778', 'D03.383.903']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Common attentional constraints in visual foraging. | Predators are known to select food of the same type in non-random sequences or "runs" that are longer than would be expected by chance. If prey are conspicuous, predators will switch between available sources, interleaving runs of different prey types. However, when prey are cryptic, predators tend to focus on one food... | ['Adult', 'Animals', 'Attention', 'Female', 'Humans', 'Male', 'Predatory Behavior', 'Visual Perception', 'Young Adult'] | 24,964,082 | [['M01.060.116'], ['B01.050'], ['F02.830.104.214'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.113.111.600', 'F01.145.113.252.520'], ['F02.463.593.932'], ['M01.060.116.815']] | ['Named Groups [M]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Functional analysis of dicer-2 missense mutations in the siRNA pathway of Drosophila. | The Drosophila RNase III enzyme Dicer-2 processes double-stranded RNA (dsRNA) precursors into small interfering RNAs (siRNAs). It also interacts with the siRNA product and R2D2 protein to facilitate the assembly of an RNA-induced silencing complex (RISC) that mediates RNA interference. Here, we characterized six indepe... | ['Alleles', 'Amino Acid Sequence', 'Animals', 'DNA Mutational Analysis', 'Drosophila Proteins', 'Drosophila melanogaster', 'Molecular Sequence Data', 'Mutation, Missense', 'Protein Structure, Tertiary', 'RNA Helicases', 'RNA, Small Interfering', 'Ribonuclease III', 'Structure-Activity Relationship'] | 18,454,937 | [['G05.360.340.024.340.030'], ['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['E05.393.760.700.300'], ['D12.776.093.500.462'], ['B01.050.500.131.617.720.500.500.750.310.250.500'], ['L01.453.245.667'], ['G05.365.590.650'], ['G02.111.570.820.709.610'], ['D08.811.913.696.445.735.720'], ['D13.150.650.700', 'D13.4... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Supercharged reverse-flow sural flap: a new modification increasing the reliability of the flap. | The management of soft-tissue defects in the lower third of the leg and foot presents a considerable problem because of composite tissue defects, inadequate and tight local tissue for reconstruction, and poor circulation. Although the reverse sural flap is frequently preferred and is fairly reliable, some complications... | ['Adult', 'Anastomosis, Surgical', 'Child, Preschool', 'Female', 'Foot Diseases', 'Foot Injuries', 'Humans', 'Leg Injuries', 'Male', 'Melanoma', 'Middle Aged', 'Surgical Flaps'] | 15,481,044 | [['M01.060.116'], ['E04.035'], ['M01.060.406.448'], ['C05.360', 'C17.800.321'], ['C26.558.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C26.558'], ['C04.557.465.625.650.510', 'C04.557.580.625.650.510', 'C04.557.665.510'], ['M01.060.116.630'], ['A10.850.710', 'E07.862.710']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Antiviral effect of lithium chloride on porcine epidemic diarrhea virus in vitro. | Porcine epidemic diarrhea virus (PEDV), a member of the Coronaviridae family, causes acute diarrhea, vomiting, dehydration, and high mortality rates in neonatal piglets. Severe outbreaks of PEDV variants have re-emerged in Asia and North America since 2010, causing tremendous economic losses to the swine industry. The ... | ['Animals', 'Antiviral Agents', 'Chlorocebus aethiops', 'Coronavirus Infections', 'In Vitro Techniques', 'Lithium Chloride', 'Porcine epidemic diarrhea virus', 'Swine', 'Swine Diseases', 'Vero Cells'] | 29,547,727 | [['B01.050'], ['D27.505.954.122.388'], ['B01.050.150.900.649.313.988.400.112.199.120.126.110'], ['C01.925.782.600.550.200'], ['E05.481'], ['D01.210.450.150.450', 'D01.510.500'], ['B04.820.578.500.540.150.075.937'], ['B01.050.150.900.649.313.500.880'], ['C22.905'], ['A11.251.210.955', 'A11.436.955']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Isolation of foot-and-mouth disease virus specific bovine antibody fragments from phage display libraries. | Foot-and-mouth disease virus (FMDV) is an important veterinary pathogen which can cause widespread epidemics. Due to the high antigenic variability of FMDV, it is important to undertake mutation analysis under immunological pressure. To study the bovine antibody response at a molecular level, phage display technology w... | ['Amino Acid Sequence', 'Animals', 'Antibodies, Viral', 'Base Sequence', 'Blotting, Western', 'Cattle', 'Cattle Diseases', 'Cloning, Molecular', 'DNA, Viral', 'Enzyme-Linked Immunosorbent Assay', 'Epitopes', 'Foot-and-Mouth Disease', 'Foot-and-Mouth Disease Virus', 'Gene Library', 'Immunoglobulin Fragments', 'Immunoglo... | 15,087,230 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D12.776.124.486.485.114.254', 'D12.776.124.790.651.114.254', 'D12.776.377.715.548.114.254'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['B01.0... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
A complicated case of altered sensorium. | Tuberculosis and malaria are two common diseases afflicting the population of the Indian subcontinent. Both are associated with fatal neurological complications. Clinically, it may be difficult to differentiate between the two, except for that the focal neurological complications are more common with central nervous sy... | ['Diagnosis, Differential', 'Female', 'Humans', 'Malaria, Cerebral', 'Middle Aged', 'Sensation Disorders', 'Tuberculoma, Intracranial'] | 23,955,980 | [['E01.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C01.207.205.300.500', 'C01.610.105.300.500', 'C01.610.752.530.620', 'C01.920.875.620', 'C10.228.228.205.300.500'], ['M01.060.116.630'], ['C10.597.751', 'C23.888.592.763'], ['C01.150.252.223.850.400', 'C01.150.252.410.040.552.846.493.400', 'C01.150.252.410... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Transcription of synthetic oligonucleotides]. | The decadeoxynucleotides d(pTTC)3 and d(CCATCTTTT) transcription by E. coli RNA-polymerase was studied. The nucleotide composition of d(pTTC)3 transcript was shown to be consistent with that of the template, but RNA-product was several times longer than the template. With nonanucleotide d(CCATCTTTT) the poly(A) synthes... | ['DNA-Directed RNA Polymerases', 'Escherichia coli', 'Kinetics', 'Oligodeoxyribonucleotides', 'Oligonucleotides', 'Templates, Genetic', 'Transcription, Genetic'] | 381,899 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Characteristics of cognitive impairment of different infarct locations among patients after acute ischemic stroke]. | OBJECTIVE: To investigate the characteristics of cognitive function changes of different infarct sites among patients after acute ischemic stroke, so as to provide theoretical basis for preventing and treating vascular cognitive dysfunction.METHODS: One hundred and five cases of acute ischemic stroke within fourteen da... | ['Attention', 'Brain', 'Brain Infarction', 'Cognition', 'Cognition Disorders', 'Cognitive Dysfunction', 'Humans', 'Language', 'Memory', 'Neuropsychological Tests', 'Stroke'] | 27,117,369 | [['F02.830.104.214'], ['A08.186.211'], ['C10.228.140.300.150.477', 'C10.228.140.300.775.200', 'C14.907.253.092.477', 'C14.907.253.855.200', 'C23.550.513.355.250', 'C23.550.717.489.250'], ['F02.463.188'], ['F03.615.250'], ['F03.615.250.700'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.209.399', 'L01.559'... | ['Psychiatry and Psychology [F]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Information Science [L]'] | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
The removal of cystic duct and gallbladder remnant by microlaparotomy. | The so called "Postcholecystectomy Syndrome" may be due to various pathological biliary causes. While a very small number of patients may have symptoms attributable to problems related to cholecystectomy. Twenty five patients underwent a second operation on the bile ducts after cholecystectomy, cholecystostomy and chol... | ['Bile Ducts', 'Cholecystectomy', 'Cholecystostomy', 'Choledochostomy', 'Cicatrix', 'Cystic Duct', 'Gallbladder', 'Gallstones', 'Humans', 'Inflammation', 'Laparoscopy', 'Laparotomy', 'Microsurgery', 'Minimally Invasive Surgical Procedures', 'Postoperative Complications', 'Recurrence', 'Reoperation', 'Risk Factors', 'Sy... | 9,408,381 | [['A03.159.183'], ['E04.210.120.172'], ['E04.035.195', 'E04.210.120.195'], ['E04.035.200', 'E04.210.120.200'], ['A10.165.450.300', 'C23.550.355.274', 'G16.762.891.249'], ['A03.159.183.079.450'], ['A03.159.439'], ['C06.130.409.633', 'C06.130.564.332.500', 'C23.300.175.525'], ['B01.050.150.900.649.313.988.400.112.400.400... | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Comparative potencies of calcium channel antagonists and antischizophrenic drugs on central and peripheral calcium channel binding sites. | Dihydropyridines are potent agents on [3H]nitrendipine binding sites in heart and brain membranes. Like the phenylalkylamines, they are slightly more active on heart than on brain [3H]nitrendipine binding sites. On the other hand, the diphenylalkylamines, the diphenylpiperazines and the antischizophrenic drugs of the d... | ['Animals', 'Antipsychotic Agents', 'Binding Sites', 'Binding, Competitive', 'Calcium Channel Blockers', 'Cerebral Cortex', 'In Vitro Techniques', 'Ion Channels', 'Male', 'Myocardium', 'Nifedipine', 'Nitrendipine', 'Rats', 'Rats, Inbred Strains'] | 2,410,588 | [['B01.050'], ['D27.505.696.277.950.040', 'D27.505.954.427.210.950.040', 'D27.505.954.427.700.872.331'], ['G02.111.570.120'], ['E05.196.080', 'G02.111.084', 'G02.111.570.120.309'], ['D27.505.519.562.249', 'D27.505.696.260.500', 'D27.505.954.411.192'], ['A08.186.211.200.885.287.500'], ['E05.481'], ['D12.776.157.530.400'... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Clinical presentation and biochemical abnormalities in black (Zulu) patients with cirrhosis in Durban. | A retrospective was designed to analyse the mode of presentation, clinical signs and haematological and biochemical abnormalities in 225 consecutive Black (Zulu) patients who were admitted to a general medical ward between the years 1970 and 1981 and in whom cirrhosis was later diagnosed. The most common presenting com... | ['Abdomen', 'Adolescent', 'Adult', 'Aged', 'Blood Cell Count', 'Child', 'Edema', 'Female', 'Hepatomegaly', 'Humans', 'Liver Cirrhosis, Alcoholic', 'Male', 'Middle Aged', 'Pain', 'Retrospective Studies'] | 7,079,888 | [['A01.923.047'], ['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['E01.370.225.500.195.107', 'E01.370.225.625.107', 'E05.200.500.195.107', 'E05.200.625.107', 'E05.242.195.107', 'G04.140.107', 'G09.188.105'], ['M01.060.406'], ['C23.888.277'], ['C06.552.416', 'C23.300.775.525'], ['B01.050.150.900.649.313.988.400.... | ['Anatomy [A]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Benign symptomatic hyperandrogenism in a postmenopausal woman. | Hyperandrogenemia in postmenopausal women requires an evaluation to exclude pathologic ovarian or adrenal causes. Our patient exhibited no signs of hypercortisolism, congenital adrenal hyperplasia, or adrenal or ovarian neoplasia based on biochemical testing and pelvic sonography. We hypothesized that unexplained andro... | ['Aged', 'Aged, 80 and over', 'Female', 'Follicle Stimulating Hormone', 'Gonadal Steroid Hormones', 'Humans', 'Hydrocortisone', 'Leuprolide', 'Luteinizing Hormone', 'Menopause', 'Virilism'] | 1,743,531 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['D06.472.699.322.576.288', 'D06.472.699.631.525.343.288', 'D12.644.548.691.525.343.288'], ['D06.472.334.851'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D04.210.500.745.745.654.600', 'D06.472.040.585.353.476', 'D06.472.040.585.478.392'], ['D06.472.699.327.740.320... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The identification of the sympathetic neurons innervating the hamster submandibular gland and their electrophysiological membrane properties. | The neuron innervating the hamster submandibular (SM) gland was identified in the superior cervical ganglion (SCG) in vitro by recording the antidromic response using the intracellular recording technique. After the cellular response was recorded, methylene blue was injected iontophoretically into the neuron from the r... | ['4-Aminopyridine', 'Animals', 'Calcium Channels', 'Cell Size', 'Coloring Agents', 'Cricetinae', 'Electric Conductivity', 'Electric Impedance', 'Electrodes, Implanted', 'Electrophysiology', 'Evoked Potentials', 'Excitatory Postsynaptic Potentials', 'Iontophoresis', 'Membrane Potentials', 'Methylene Blue', 'Microelectro... | 11,484,792 | [['D02.092.080.060', 'D03.383.725.050.060'], ['B01.050'], ['D12.776.157.530.400.150', 'D12.776.543.550.450.150', 'D12.776.543.585.400.150'], ['G04.325'], ['D27.720.233'], ['B01.050.150.900.649.313.992.635.075.250'], ['G01.358.500.249.277'], ['G01.358.500.249.277.350'], ['E07.305.250.319', 'E07.695.202'], ['H01.158.344.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Primary invasive squamous carcinoma of the vagina. | Forty-three cases of primary vaginal squamous cell cancer were treated at the University of Wisconsin Hospital between 1956 and 1971. These cases comprised 1.2% of patients admitted to the University Hospital with female genital tract cancer. Evidence is presented to support a modification of the currently accepted FIG... | ['Adult', 'Aged', 'Carcinoma, Squamous Cell', 'Colitis', 'Colon, Sigmoid', 'Female', 'Humans', 'Middle Aged', 'Neoplasms, Radiation-Induced', 'Proctitis', 'Radiotherapy', 'Rectovaginal Fistula', 'Vaginal Diseases', 'Vaginal Neoplasms', 'Vesicovaginal Fistula'] | 418,978 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Transsphenoidal microsurgical results of non-invasive prolactinomas]. | OBJECTIVE: To analyze the transsphenoidal microsurgical results of non-invasive prolactinomas, in order to provide reference for their treatment choice.METHODS: To review the transsphenoidal microsurgical results of 234 non-invasive prolactinomas treated in our department in recent 10 years, and to analyze the prognost... | ['Adolescent', 'Adult', 'Female', 'Follow-Up Studies', 'Humans', 'Hypophysectomy', 'Male', 'Microsurgery', 'Middle Aged', 'Pituitary Neoplasms', 'Prolactinoma', 'Retrospective Studies', 'Sphenoid Sinus', 'Treatment Outcome'] | 18,683,769 | [['M01.060.057'], ['M01.060.116'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.270.532', 'E04.525.400'], ['E04.494', 'E05.591.580'], ['M01.060.116.630'], ['C04.588.322.609', 'C04.588.614.250.195.885.500.600', 'C10.228.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Extended interaction of beta1 integrin subunit-deficient cells (GD25) with surfaces modified with fibronectin-derived peptides: Culture optimization, adhesion and cytokine panel studies. | The modification of biomaterials with extracellular matrix-mimicking factors is a common technique used to influence the cellular response through integrin-mediated signaling. The inherent limitations of antibody-inhibition studies necessitate the use of complementary methods to block integrin function to confirm cell-... | ['Animals', 'Biomimetic Materials', 'Cell Adhesion', 'Cell Culture Techniques', 'Cell Line', 'Coated Materials, Biocompatible', 'Cytokines', 'Fibroblasts', 'Fibronectins', 'Integrin beta1', 'Materials Testing', 'Mice', 'Peptides', 'Surface Properties', 'Tissue Engineering'] | 18,514,047 | [['B01.050'], ['J01.637.087'], ['G04.022'], ['E01.370.225.500.223', 'E05.200.500.265', 'E05.242.223', 'E05.481.500.249'], ['A11.251.210'], ['D25.130.420', 'J01.637.051.130.420'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['A11.329.228'], ['D12.776.377.715.390', 'D12.776.395.550.350', 'D12.776.543.550.350',... | ['Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Vehicular traffic noise prediction and propagation modelling using neural networks and geospatial information system. | This study proposes a neural network (NN) model to predict and simulate the propagation of vehicular traffic noise in a dense residential area at the New Klang Valley Expressway (NKVE) in Shah Alam, Malaysia. The proposed model comprises of two main simulation steps: that is, the prediction of vehicular traffic noise u... | ['Environmental Monitoring', 'Geographic Information Systems', 'Malaysia', 'Models, Theoretical', 'Motor Vehicles', 'Neural Networks, Computer', 'Noise, Transportation'] | 30,809,746 | [['N06.850.460.350.080', 'N06.850.780.375'], ['L01.313.500.750.300.314', 'L01.470.750.750.462'], ['Z01.252.145.487'], ['E05.599'], ['J01.937.500'], ['G17.485', 'L01.224.050.375.605'], ['N06.230.400.550', 'N06.850.460.610.680']] | ['Health Care [N]', 'Information Science [L]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 |
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