Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Epidemiology of Kawasaki disease in Italy: surveillance from national hospitalization records. | Kawasaki disease is a systemic vasculitis with an acute and self-limited course. The incidence of the disease differs widely among ethnic groups and is higher in the Asian populations. In Italy, no recent data are available. We studied the epidemiology of Kawasaki disease in the years 2008-2013 in children 0-14 years o... | ['Adolescent', 'Child', 'Child, Preschool', 'Databases, Factual', 'Female', 'Hospitalization', 'Humans', 'Incidence', 'Infant', 'Infant, Newborn', 'Italy', 'Male', 'Mucocutaneous Lymph Node Syndrome', 'Public Health Surveillance'] | 28,612,175 | [['M01.060.057'], ['M01.060.406'], ['M01.060.406.448'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['E02.760.400', 'N02.421.585.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.985.525.375'], ['M01.060.703... | ['Named Groups [M]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
A case of M?n?trier disease in a child. | M?n?trier disease is a protein-losing gastroenteropathy often misdiagnosed in the pediatric population. The disease is characterized by hypoalbuminemia secondary to protein loss through the gastrointestinal mucosa and resultant peripheral edema. It is important for emergency department practitioners to consider this di... | ['Child, Preschool', 'Gastritis, Hypertrophic', 'Humans', 'Male'] | 22,391,924 | [['M01.060.406.448'], ['C06.405.205.697.410', 'C06.405.748.398.410'], ['B01.050.150.900.649.313.988.400.112.400.400']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Preparation and application of rabbit anti-mouse Setd8 polyclonal antibody]. | Objective: To purify the recombinant Setd8 protein and prepare rabbit anti-mouse Setd8 polyclonal antibody.Methods: The recombinant plasmid p ET-30a-Setd8 was constructed by double enzyme digestion and linkage,and then transformed into E. coli BL21. The expression of the target protein was induced by IPTG and the expre... | ['Animals', 'Antibodies', 'Antibody Affinity', 'Antibody Specificity', 'Blotting, Western', 'Enzyme-Linked Immunosorbent Assay', 'Escherichia coli', 'Histone-Lysine N-Methyltransferase', 'Immunohistochemistry', 'Mice', 'Plasmids', 'Rabbits', 'Recombinant Proteins'] | 29,763,214 | [['B01.050'], ['D12.776.124.486.485.114', 'D12.776.124.790.651.114', 'D12.776.377.715.548.114'], ['G12.040', 'G12.122.125'], ['G12.100'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.47... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Mechanical characteristics of dilated polytetraflouroethylene used for transluminally placed endovascular grafts. | This study was conducted to assess the mechanical characteristics of dilated polytetraflouroethylene (PTFE) for use in transluminally placed endovascular grafts (TPEGs). Ten-centimeter lengths of 3- and 4-mm thinwalled PTFE were dilated to 8, 10, 12, and 15 mm diameters (3 mm) and 10-, 14-, 16-, and 20-mm diameters (4 ... | ['Blood Vessel Prosthesis', 'Catheterization', 'Humans', 'Microscopy, Electron, Scanning', 'Perfusion', 'Polytetrafluoroethylene', 'Prosthesis Failure', 'Stress, Mechanical', 'Time Factors'] | 9,061,142 | [['E07.695.110'], ['E02.148', 'E05.157'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.515.402.541', 'E05.595.402.541'], ['E05.680'], ['D05.750.395.616', 'D25.720.395.616', 'J01.637.051.720.395.616'], ['C23.550.767.865', 'E05.325.771'], ['G01.374.835'], ['G01.910.857']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
A parallel group double-blind RCT of vitamin D3 assessing physical function: is the biochemical response to treatment affected by overweight and obesity? | UNLABELLED: Vitamin D may affect skeletal muscle function. In a double-blind, randomised, placebo-controlled trial, we found that vitamin D3 supplementation (400 or 1,000 I.U. vs. placebo daily for 1 year with bimonthly study visits) does not improve grip strength or reduce falls.INTRODUCTION: This study aimed to test ... | ['Accidental Falls', 'Aged', 'Anthropometry', 'Body Composition', 'Body Mass Index', 'Calcium', 'Cholecalciferol', 'Diet', 'Dietary Supplements', 'Dose-Response Relationship, Drug', 'Double-Blind Method', 'Female', 'Hand Strength', 'Humans', 'Middle Aged', 'Motor Activity', 'Obesity', 'Overweight', 'Phosphates', 'Sunli... | 23,982,800 | [['N06.850.135.122'], ['M01.060.116.100'], ['E01.370.600.024', 'E05.041', 'N06.850.505.200.100'], ['G02.111.130', 'G03.180', 'G07.100.049'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D04.210.500.247.222.159', 'D... | ['Health Care [N]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Resistin gene variation is associated with systemic inflammation but not plasma adipokine levels, metabolic syndrome or coronary atherosclerosis in nondiabetic Caucasians. | OBJECTIVE: Resistin causes insulin resistance and diabetes in mice whereas in humans it is linked to inflammation and atherosclerosis. Few human genetic studies of resistin in inflammation and atherosclerosis have been performed. We hypothesized that the -420C>G putative gain-of-function resistin variant would be assoc... | ['Adipokines', 'Adiposity', 'Adult', 'Biomarkers', 'Coronary Artery Disease', 'Cytokines', 'European Continental Ancestry Group', 'Female', 'Gene Frequency', 'Genetic Variation', 'Haplotypes', 'Humans', 'Inflammation', 'Inflammation Mediators', 'Linkage Disequilibrium', 'Male', 'Metabolic Syndrome', 'Middle Aged', 'Pol... | 18,710,472 | [['D06.472.699.042', 'D12.644.276.024', 'D12.644.548.011', 'D12.776.467.024', 'D23.529.024'], ['E01.370.600.115.100.062.500', 'G02.111.130.134.500', 'G03.180.134.500', 'G07.100.049.134.500'], ['M01.060.116'], ['D23.101'], ['C14.280.647.250.260', 'C14.907.137.126.339', 'C14.907.585.250.260'], ['D12.644.276.374', 'D12.77... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Named Groups [M]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Differential toxicity of processed and non-processed states of CoCrMo degradation products generated from a hip simulator on neural cells. | Physico-chemical characteristics of the CoCrMo degradation products have played an important role in cytotoxicity and clinical complications on the orthopedic patients who have metal implants. Previous studies have limited reflection on the physicochemical characteristics of the degradation products generated in vivo, ... | ['Apoptosis', 'Cell Differentiation', 'Cell Survival', 'Dose-Response Relationship, Drug', 'Hip Prosthesis', 'Humans', 'Induced Pluripotent Stem Cells', 'Materials Testing', 'Middle Aged', 'Neurons', 'Oxidation-Reduction', 'Protein Corona', 'Reactive Oxygen Species', 'Surface Properties', 'Vitallium'] | 30,251,573 | [['G04.146.954.035'], ['G04.152'], ['G04.346'], ['G07.690.773.875', 'G07.690.936.500'], ['E07.695.400.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.872.040.500', 'A11.872.700.500'], ['E05.570'], ['M01.060.116.630'], ['A08.675', 'A11.671'], ['G02.700', 'G03.295.531'], ['D12.776.642'], ['D01.339.431', 'D0... | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 |
Susceptibility testing of Aspergillus flavus: inoculum dependence with itraconazole and lack of correlation between susceptibility to amphotericin B in vitro and outcome in vivo. | We have attempted to validate in Aspergillus flavus the main in vitro methodologies that have been used to detect resistance in Aspergillus fumigatus. We developed a murine model with two A. flavus isolates, one that was apparently resistant in vitro to amphotericin B (AFL5) and another that was resistant to itraconazo... | ['Amphotericin B', 'Animals', 'Antifungal Agents', 'Aspergillosis', 'Aspergillus flavus', 'Disease Models, Animal', 'Drug Resistance, Microbial', 'Itraconazole', 'Male', 'Mice', 'Microbial Sensitivity Tests', 'Statistics as Topic'] | 11,302,810 | [['D02.540.576.500.500'], ['B01.050'], ['D27.505.954.122.136'], ['C01.150.703.080'], ['B01.300.381.081.170'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['G06.225', 'G07.690.773.984.269'], ['D03.383.129.799.550', 'D03.383.606.530'], ['B01.050.150.900.649.313.992.635.505.500'], ['E01.370.225.875.595', 'E05.200.875.5... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Clinical and neuroimaging features of severely brain-injured patients treated in a neurosurgical unit compared with patients treated in peripheral non-neurosurgical hospitals. | Most European TBI patients are managed in peripheral hospitals without benefit of guidelines for transfer of such patients to neurosurgical units as needed. This report compares clinical features and outcomes in two series of severe TBI patients: those admitted to a neurosurgical centre or to a general hospital, all in... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Brain Injuries', 'Child', 'Child, Preschool', 'Female', 'Glasgow Outcome Scale', 'Hospitalization', 'Hospitals, General', 'Humans', 'Infant', 'Male', 'Middle Aged', 'Neurosurgical Procedures', 'Tomography, X-Ray Computed', 'Treatment Outcome'] | 16,753,622 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C10.228.140.199', 'C10.900.300.087', 'C26.915.300.200'], ['M01.060.406'], ['M01.060.406.448'], ['E05.318.308.940.968.875.260', 'E05.944.510', 'N04.452.859.564.800.260', 'N05.715.360.300.715.500.800.335'], ['E02.760.400', 'N02.421.585.400... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Human peripheral blood lymphocytes targeted with bispecific antibodies release cytokines that are essential for inhibiting tumor growth. | We have compared the mechanisms by which human PBL targeted with bispecific antibodies either lyse tumor cells or block their growth in culture or in mice. We found that resting PBL were unable to mediate lysis, but were able to block tumor growth. Moreover, targeted PBL were unable to lyse bystander cells, whereas tar... | ['Animals', 'Antibodies, Neoplasm', 'Antibody Specificity', 'Antigens, CD', 'Antigens, Differentiation', 'Antigens, Differentiation, T-Lymphocyte', 'CD3 Complex', 'Cytokines', 'Humans', 'Immunotherapy', 'Interferon-gamma', 'Isoantibodies', 'Lymphocytes', 'Lymphotoxin-alpha', 'Mice', 'Mice, Nude', 'Neoplasm Transplantat... | 1,826,709 | [['B01.050'], ['D12.776.124.486.485.114.240', 'D12.776.124.790.651.114.240', 'D12.776.377.715.548.114.240'], ['G12.100'], ['D23.050.301.264.035', 'D23.101.100.110'], ['D23.050.301.264', 'D23.101.100'], ['D23.050.301.264.894', 'D23.101.100.894'], ['D23.050.301.264.894.095', 'D23.101.100.894.095'], ['D12.644.276.374', 'D... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Clinical characteristics of T790M-positive lung adenocarcinoma after resistance to epidermal growth factor receptor-tyrosine kinase inhibitors with an emphasis on brain metastasis and survival. | OBJECTIVES: We aimed to investigate the clinical characteristics of lung adenocarcinomas with acquired EGFR T790M mutation focusing on brain metastasis and survival.MATERIALS AND METHODS: Our study included patients who had lung adenocarcinoma harboring EGFR mutation at 1st biopsy and then underwent 2nd biopsy after re... | ['Acrylamides', 'Adenocarcinoma of Lung', 'Adult', 'Aged', 'Aged, 80 and over', 'Aniline Compounds', 'Antineoplastic Agents', 'Brain Neoplasms', 'Drug Resistance, Neoplasm', 'ErbB Receptors', 'Female', 'Humans', 'Lung Neoplasms', 'Male', 'Middle Aged', 'Mutation', 'Neoplasm Metastasis', 'Piperazines', 'Prognosis', 'Pro... | 29,858,020 | [['D02.065.122', 'D02.241.081.069.094'], ['C04.557.470.200.025.022', 'C04.588.894.797.520.055'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D02.092.146'], ['D27.505.954.248'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['G07.690.773.984.395'], ['D08.811.913.696.620.682.725.400.... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
BDNF contributes to both rapid and homeostatic alterations in AMPA receptor surface expression in nucleus accumbens medium spiny neurons. | Brain-derived neurotrophic factor (BDNF) plays a critical role in plasticity at glutamate synapses and in the effects of repeated cocaine exposure. We recently showed that intracranial injection of BDNF into the rat nucleus accumbens (NAc), a key region for cocaine addiction, rapidly increases á-amino-3-hyroxy-5-methyl... | ['Animals', 'Bicuculline', 'Brain-Derived Neurotrophic Factor', 'Cells, Cultured', 'Excitatory Postsynaptic Potentials', 'Homeostasis', 'Mice', 'Neurons', 'Nucleus Accumbens', 'Protein Transport', 'Rats', 'Rats, Sprague-Dawley', 'Receptors, AMPA', 'Synaptic Membranes'] | 24,712,995 | [['B01.050'], ['D03.132.098.077', 'D03.633.100.531.085.077'], ['D12.644.276.860.100', 'D12.776.467.860.100', 'D12.776.631.600.100', 'D23.529.850.100'], ['A11.251'], ['G04.580.887.249', 'G07.265.675.887.249', 'G07.265.880.750.199', 'G11.561.570.918.249', 'G11.561.830.750.199'], ['G07.410'], ['B01.050.150.900.649.313.992... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Otolaryngology outreach to Komfo Anokye Teaching Hospital: a medical and educational partnership. | BACKGROUND: Medical and educational partnerships between high- and low-resourced countries provide opportunities to have a long-term meaningful impact on medical training and healthcare delivery.METHODS: An otolaryngology partnership between Komfo Anokye Teaching Hospital in Kumasi, Ghana, and the University of Michiga... | ['Delivery of Health Care', 'Developing Countries', 'Durable Medical Equipment', 'Ghana', 'Hospitals, Teaching', 'Hospitals, University', 'Humans', 'International Cooperation', 'Internship and Residency', 'Michigan', 'Otolaryngology'] | 28,193,299 | [['N04.590.374', 'N05.300'], ['I01.615.500.300'], ['E07.278'], ['Z01.058.290.190.320'], ['N02.278.020.300', 'N02.278.421.639'], ['N02.278.020.300.310', 'N02.278.421.639.725'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I01.615.500'], ['I02.358.337.350.500', 'I02.358.399.350.750'], ['Z01.107.567.875.350.500', 'Z... | ['Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 |
Lactate dehydrogenase and Haemolysis Index as quality control markers of haemolysis in intra-operative cell salvage. | OBJECTIVES: The aim of this investigation was to explore the potential use of the tests lactate dehydrogenase (LDH) and Haemolysis Index as haemolysis markers in intra-operative cell salvage (ICS) blood in comparison to plasma free haemoglobin levels.BACKGROUND: Quality control (QC) should be seen as a fundamental part... | ['Biomarkers', 'Female', 'Hemoglobins', 'Hemolysis', 'Humans', 'L-Lactate Dehydrogenase', 'Male', 'Operative Blood Salvage', 'Quality Control'] | 23,849,190 | [['D23.101'], ['D12.776.124.400', 'D12.776.422.316.762'], ['C23.550.403', 'G12.122.545'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.682.047.551.400', 'D08.811.682.047.820.493'], ['E04.936.537.687'], ['J01.897.608']] | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Retrieval and monitoring of atmospheric trace gas concentrations in nadir and limb geometry using the space-borne SCIAMACHY instrument. | The Scanning Imaging Absorption Spectrometer for Atmospheric Chartography (SCIAMACHY) onboard the European Envisat spacecraft performs continuous spectral observations of reflected, scattered and transmitted sunlight in various observation geometries. A unique feature of SCIAMACHY is the capability of probing the atmos... | ['Air Pollutants', 'Atmosphere', 'Environmental Monitoring', 'Gases', 'Nitrogen Dioxide', 'Ozone', 'Spacecraft'] | 16,715,354 | [['D27.888.284.101'], ['G16.500.275.063', 'N06.230.300.100'], ['N06.850.460.350.080', 'N06.850.780.375'], ['D01.362'], ['D01.362.635.600', 'D01.625.550.525', 'D01.650.550.587.625'], ['D01.362.670.600'], ['J01.937.285.850.900']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Chlormethiazole as sleep cover for the elderly. Intravenous infusion during local analgesia. | A method of avoiding postoperative confusion when local analgesic techniques are indicated for the elderly is described. Basal sedation using 0.8% chlormethiazole infusion intravenously, was employed. Mental function was not altered when the technique was used and it is suggested that the length of stay in hospital can... | ['Aged', 'Anesthesia, Intravenous', 'Anesthesia, Local', 'Chlormethiazole', 'Humans', 'Intelligence Tests', 'Postoperative Period', 'Preoperative Care'] | 7,435,903 | [['M01.060.116.100'], ['E03.155.308'], ['E03.155.086.231'], ['D02.886.675.180', 'D03.383.129.708.180'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F04.711.141.493'], ['E04.614.750', 'N02.421.585.753.750'], ['E02.760.795', 'E04.604.750', 'N02.421.585.795']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Post-Transplant Recurrence of Focal Segmental Glomerulosclerosis in a Child With Heterozygous Mutations in NPHS1 and NPHS2. | Renal transplantation is the optimal renal replacement therapy (RRT) in children, but some primary diseases can recur after transplantation, and recurrence accounts for a significant proportion of graft losses, being second only to acute rejection. The risk of disease recurrence is highest among patients with idiopathi... | ['Child', 'Disease Progression', 'Female', 'Glomerulosclerosis, Focal Segmental', 'Humans', 'Intracellular Signaling Peptides and Proteins', 'Kidney Failure, Chronic', 'Kidney Transplantation', 'Membrane Proteins', 'Mutation', 'Recurrence'] | 27,312,921 | [['M01.060.406'], ['C23.550.291.656'], ['C12.777.419.570.363.660', 'C13.351.968.419.570.363.640'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.360', 'D12.776.476'], ['C12.777.419.780.750.500', 'C13.351.968.419.780.750.500'], ['E02.870.500', 'E04.936.450.485', 'E04.950.774.400'], ['D12.776.543'], ['G05.36... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Isolated noncompaction of the ventricular myocardium. A study in an adult male and literature review. | Noncompaction of the ventricular myocardium is a rare congenital disorder characterized by the presence of numerous prominent trabeculations and deep intertrabecular recesses which communicate with the left ventricular cavity. The disease uniformly affects the left ventricle, sometimes also affecting the right ventricl... | ['Adult', 'Echocardiography', 'Heart Ventricles', 'Humans', 'Male', 'Myocardium'] | 10,832,816 | [['M01.060.116'], ['E01.370.350.130.750', 'E01.370.350.850.220', 'E01.370.370.380.220'], ['A07.541.560'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.633.580', 'A07.541.704', 'A10.690.552.750']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Flightless I exacerbation of inflammatory responses contributes to increased colonic damage in a mouse model of dextran sulphate sodium-induced ulcerative colitis. | Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by cytokine driven inflammation that disrupts the mucosa and impedes intestinal structure and functions. Flightless I (Flii) is an immuno-modulatory protein is a member of the gelsolin family of actin-remodelling proteins that regulates cellu... | ['Adult', 'Animals', 'Colitis, Ulcerative', 'Colon', 'Dextran Sulfate', 'Disease Models, Animal', 'Female', 'Humans', 'Inflammation', 'Mice', 'Mice, Inbred BALB C', 'Microfilament Proteins', 'Trans-Activators', 'Wnt Proteins'] | 31,488,864 | [['M01.060.116'], ['B01.050'], ['C06.405.205.265.231', 'C06.405.205.731.249', 'C06.405.469.158.188.231', 'C06.405.469.432.249'], ['A03.556.124.526.356', 'A03.556.249.249.356'], ['D09.698.365.272.300'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.470'], ['B01... | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Results of dobutamine stress echocardiography in patients with syndrome X. | This study describes the results of Dobutamine stress echocardiography in 10 patients with Syndrome X. The diagnosis of Syndrome X was made on the basis of the presence of exertional angina, positive exercise stress test, negative ergonovine stress test and normal coronary arteries at angiography. All patients underwen... | ['Adult', 'Angina Pectoris', 'Blood Pressure', 'Coronary Angiography', 'Dobutamine', 'Echocardiography', 'Electrocardiography', 'Ergonovine', 'Exercise Test', 'Female', 'Heart Rate', 'Humans', 'Male', 'Microvascular Angina', 'Middle Aged', 'Myocardial Contraction', 'Myocardial Ischemia', 'Ventricular Function, Left'] | 7,963,753 | [['M01.060.116'], ['C14.280.647.187', 'C14.907.585.187', 'C23.888.592.612.233.500'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E01.370.350.130.625', 'E01.370.350.700.060.200', 'E01.370.370.050.200', 'E01.370.370.380.200'], ['D02.092.311.220', 'D02.092.471.683.410', 'D02.455.426.559.389.657.166.175.220'], ['E01.370.... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Facial profileplasty by liposuction extraction. | Facial profileplasty can include the removal of abnormal fat deposits in the face and neck as an individual begins to age and, in many cases, the correction of chin projection to achieve a better neck-chin contour line. In this report we retrospectively analyze the complications and results from 142 patients undergoing... | ['Adipose Tissue', 'Adult', 'Aged', 'Bandages', 'Esthetics', 'Face', 'Female', 'Humans', 'Male', 'Middle Aged', 'Postoperative Care', 'Preoperative Care', 'Retrospective Studies', 'Suction', 'Surgery, Plastic'] | 3,937,092 | [['A10.165.114'], ['M01.060.116'], ['M01.060.116.100'], ['E07.101'], ['F02.463.785.477', 'K01.752.210'], ['A01.456.505'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E02.760.731.700', 'E04.604.500', 'N02.421.585.722.700'], ['E02.760.795', 'E04.604.750', 'N02.421.585.795'], ['E05.318.372.500.... | ['Anatomy [A]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Humanities [K]', 'Organisms [B]', 'Health Care [N]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Effects of equisetin on rat liver mitochondria: evidence for inhibition of substrate anion carriers of the inner membrane. | The effect of equisetin, an antibiotic produced by Fusarium equiseti, has been studied on mitochondrial functions (respiration, ATPase, ion transport). Equisetin inhibits the DNP-stimulated ATPase activity of rat liver mitochondria and mitoplasts in a concentration-dependent manner; 50% inhibition is caused by about 8 ... | ['Adenosine Diphosphate', 'Adenosine Triphosphatases', 'Adenosine Triphosphate', 'Animals', 'Anions', 'Biological Transport', 'Calcium', 'Carrier Proteins', 'Energy Metabolism', 'Intracellular Membranes', 'Membrane Potentials', 'Mitochondria, Liver', 'Oxygen Consumption', 'Phosphates', 'Pyrrolidinones', 'Rats', 'Succin... | 8,132,493 | [['D03.633.100.759.646.138.124', 'D13.695.667.138.124', 'D13.695.827.068.124'], ['D08.811.277.040.025'], ['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['B01.050'], ['D01.248.497.158'], ['G03.143'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D12.776.157'], ['G03.295'], ['A1... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Versatile format of minichaperone-based protein fusion system. | Hydrophobic recombinant proteins often tend to aggregate upon expression into inclusion bodies and are difficult to refold. Producing them in soluble forms constitutes a common bottleneck problem. A fusion system for production of insoluble hydrophobic proteins in soluble stable forms with thermophilic minichaperone, G... | ['Chaperonin 60', 'Models, Molecular', 'Molecular Chaperones', 'Protein Domains', 'Recombinant Fusion Proteins', 'Solubility', 'Thermus thermophilus'] | 31,636,289 | [['D08.811.277.040.025.142.500.500', 'D12.776.580.216.210.590.750'], ['E05.599.595'], ['D12.776.580'], ['G02.111.570.820.709.275.750', 'G02.111.570.820.709.610.500'], ['D12.776.828.300'], ['G02.805'], ['B03.440.400.425.875.875']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Delayed chemokine receptor 1 blockade prolongs survival in collagen 4A3-deficient mice with Alport disease. | Human Alport disease is caused by a lack of the alpha3-, 4-, or 5-chain of type IV collagen (COL4A). Affected humans and COL4A3-deficient mice develop glomerulosclerosis and progressive renal fibrosis in the presence of interstitial macrophages, but their contribution to disease progression is under debate. This questi... | ['Animals', 'Autoantigens', 'Blood Vessels', 'Cell Adhesion', 'Cell Count', 'Chemokine CCL3', 'Chemokine CCL4', 'Chemokine CCL5', 'Chemokines, CC', 'Chemotaxis, Leukocyte', 'Collagen Type IV', 'Kidney', 'Kidney Glomerulus', 'Kidney Tubules', 'Leukocyte Rolling', 'Leukocytes', 'Macrophage Inflammatory Proteins', 'Macrop... | 15,716,328 | [['B01.050'], ['D23.050.422'], ['A07.015'], ['G04.022'], ['E01.370.225.500.195', 'E05.200.500.195', 'E05.242.195', 'G04.140'], ['D12.644.276.374.200.110.150', 'D12.644.276.374.200.600.150', 'D12.776.467.374.200.110.150', 'D12.776.467.374.200.600.150', 'D23.125.300.110.150', 'D23.125.300.600.500', 'D23.469.200.110.150',... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Persistence of hemostatic alterations in patients affected by Crohn's disease after bowel surgery. | In Crohn's disease (CD) a condition of hypercoagulability with increased risk for thrombotic events has been reported. In this study we have investigated hemostatic parameters in thirty-one patients affected by CD before, 3 and 12 months after bowel operation, and in thirty healthy controls. Before surgery platelet num... | ['Adolescent', 'Adult', 'Antibodies, Antiphospholipid', 'Colostomy', 'Crohn Disease', 'Factor XIII', 'Female', 'Fibrinogen', 'Hemostasis', 'Humans', 'Male', 'Middle Aged', 'Plasminogen Inactivators', 'Platelet Aggregation', 'Platelet Count', 'Prothrombin', 'Severity of Illness Index'] | 9,330,436 | [['M01.060.057'], ['M01.060.116'], ['D12.776.124.486.485.114.323.210', 'D12.776.124.790.651.114.323.210', 'D12.776.377.715.548.114.323.210'], ['E04.210.338.225', 'E04.579.338.225'], ['C06.405.205.731.500', 'C06.405.469.432.500'], ['D08.622.505', 'D12.776.124.125.475', 'D12.776.811.243.505', 'D23.119.475'], ['D12.776.12... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Decreasing photobleaching by silver island films: application to muscle. | Recently it has become possible to study interactions between proteins at the level of single molecules. This requires collecting data from an extremely small volume, small enough to contain one molecule-typically of the order of attoliters (10(-18) L). Collection of data from such a small volume with sufficiently high... | ['Actins', 'Animals', 'Microscopy, Atomic Force', 'Muscle, Skeletal', 'Myofibrils', 'Phalloidine', 'Photobleaching', 'Rabbits', 'Rhodamines', 'Silver'] | 17,531,183 | [['D05.750.078.730.250', 'D12.776.210.500.100', 'D12.776.220.525.255'], ['B01.050'], ['E01.370.350.515.666.400', 'E05.595.666.400'], ['A02.633.567', 'A10.690.552.500'], ['A10.690.552.875', 'A11.284.430.214.190.750.620', 'A11.620.249.850', 'A11.620.500.500'], ['D04.345.566.735', 'D12.644.456.735', 'D12.644.641.735', 'D2... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Reducing conduct problems among children exposed to intimate partner violence: a randomized clinical trial examining effects of Project Support. | This study was a randomized clinical trial of Project Support, an intervention designed to reduce conduct problems among children exposed to intimate partner violence. Participants were 66 families (mothers and children) with at least 1 child exhibiting clinical levels of conduct problems. Families were recruited from ... | ['Adult', 'Child', 'Child of Impaired Parents', 'Child, Preschool', 'Conduct Disorder', 'Education', 'Family Therapy', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Mother-Child Relations', 'Parenting', 'Social Support', 'Spouse Abuse', 'Stress Disorders, Post-Traumatic', 'Young Adult'] | 19,634,963 | [['M01.060.116'], ['M01.060.406'], ['M01.106'], ['M01.060.406.448'], ['F03.625.094.300'], ['I02'], ['F04.754.864.581.273'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.263.370.290.170'], ['F01.829.263.370.310'], ['... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Silymarin prevents apoptosis through inhibiting the Bax/caspase-3 expression and suppresses toll like receptor-4 pathway in the SNc of 6-OHDA intoxicated rats. | BACKGROUND AND PURPOSE: Several lines of evidence show that apoptosis, oxidative stress and neuroinflammation are associated with the development of Parkinson's disease (PD). In the present study, we investigated the effect of pre-treatment with silymarin (SM) on oxidative stress, apoptosis and toll-like receptor 4 (TL... | ['Animals', 'Apoptosis', 'Caspase 3', 'Glutathione Reductase', 'Male', 'Oxidative Stress', 'Oxidopamine', 'Parkinson Disease', 'Rats', 'Rats, Wistar', 'Silymarin', 'Substantia Nigra', 'Superoxide Dismutase', 'Thiobarbituric Acid Reactive Substances', 'Toll-Like Receptor 4', 'bcl-2-Associated X Protein'] | 29,772,432 | [['B01.050'], ['G04.146.954.035'], ['D08.811.277.656.262.500.126.350.300', 'D08.811.277.656.300.200.126.350.300', 'D12.644.360.075.405.350.300', 'D12.776.476.075.405.350.300'], ['D08.811.682.667.092'], ['G03.673', 'G07.775.750'], ['D02.092.311.342.478.650', 'D02.455.426.559.389.657.166.175.342.478.650'], ['C10.228.140.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Adult zebrafish as a model system for cutaneous wound-healing research. | Upon injury, the skin must quickly regenerate to regain its barrier function. In mammals, wound healing is rapid and scar free during embryogenesis, whereas in adults it involves multiple steps including blood clotting, inflammation, re-epithelialization, vascularization, and granulation tissue formation and maturation... | ['Animals', 'Animals, Genetically Modified', 'Blood Coagulation', 'Cicatrix', 'Dermatitis', 'Disease Models, Animal', 'Epithelial Cells', 'Fibroblast Growth Factors', 'Granulation Tissue', 'Neovascularization, Physiologic', 'Signal Transduction', 'Skin', 'Wound Healing', 'Zebrafish'] | 23,325,040 | [['B01.050'], ['B01.050.050.136', 'B05.620.136'], ['G09.188.390.150'], ['A10.165.450.300', 'C23.550.355.274', 'G16.762.891.249'], ['C17.800.174'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['A11.436'], ['D12.644.276.624', 'D12.776.467.624', 'D23.529.624'], ['A10.165.450'], ['G09.330.630'], ['G02.111.820', 'G04.835... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Contributions of individual syndromes to global psychopathology ratings for mental health and substance abuse patients. | Used the SCL-90 Analogue to rate nine psychiatric syndromes-and overall psychopathology in 1,046 mental health and 809 substance abuse patients admitted to a large metropolitan, community mental health center. Stepwise multiple regressions of the nine syndrome ratings on the global psychopathology ratings for each samp... | ['Adult', 'Female', 'Humans', 'Male', 'Mental Disorders', 'Psychological Tests', 'Psychometrics', 'Substance-Related Disorders'] | 7,068,890 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F03'], ['F04.711'], ['F04.711.780'], ['C25.775', 'F03.900']] | ['Named Groups [M]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Semi-automatic determination of the variations in volume of LS fibroblasts grown in the presence of saccharose]. | A method is described for determination of the volume of fibroblasts, grown in suspension, in normal medium, in medium supplemented with sucrose (Su) 0,04 and 0.08 M. A 4 days permanence in these last two mediums causes an obvious cytoplasmic vacuolation and an increase in cell volume (Tab.1) that reaches its maximum f... | ['Cells, Cultured', 'Culture Media', 'Fibroblasts', 'Sucrose'] | 7,236,415 | [['A11.251'], ['D27.720.470.305', 'E07.206'], ['A11.329.228'], ['D09.698.629.305.770', 'D09.947.750.770']] | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Secular Trends in the Cost of Immunosuppressants after Solid Organ Transplantation in the United States. | BACKGROUND AND OBJECTIVES: Immunosuppressive medications are critical for maintenance of graft function in transplant recipients but can represent a substantial financial burden to patients and their insurance carriers.DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: To determine whether availability of generic immunosup... | ['Adolescent', 'Adult', 'Aged', 'Cost Savings', 'Cost-Benefit Analysis', 'Drug Costs', 'Drug Utilization', 'Drugs, Generic', 'Female', 'Health Expenditures', 'Humans', 'Immunosuppressive Agents', 'Insurance, Health, Reimbursement', 'Male', 'Medicare Part D', 'Middle Aged', 'Organ Transplantation', 'Registries', 'Time F... | 30,819,667 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['N03.219.151.160.200'], ['N03.219.151.125'], ['N03.219.151.400.350', 'N05.300.375.300'], ['N04.452.706.477'], ['D26.360'], ['N03.219.151.450', 'N05.300.385'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.477.656'], ['N03.219.521.576.343.480', 'N... | ['Named Groups [M]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
The induction of c-fos mRNA expression by mechanical stress in human periodontal ligament cells. | The periodontal ligament is subjected to mechanical loading during occlusion and mastication. Although internuclear transcription factors are associated with the regulatory pathway that converts these extracellular mechanical stimuli into a cellular response, there are no reports on these in human periodontal ligament ... | ['1-Carboxyglutamic Acid', 'Alkaline Phosphatase', 'Bite Force', 'Bone and Bones', 'Calcium-Binding Proteins', 'Cell Culture Techniques', 'Collagen Type I', 'Collagen Type III', 'Extracellular Matrix Proteins', 'Fibroblasts', 'Gene Expression Regulation', 'Humans', 'Mastication', 'Osteocalcin', 'Osteonectin', 'Osteopon... | 12,102,763 | [['D02.241.081.901.400', 'D12.125.067.625.174', 'D12.125.119.409.174'], ['D08.811.277.352.650.035'], ['E06.276.125'], ['A02.835.232', 'A10.165.265'], ['D12.776.157.125'], ['E01.370.225.500.223', 'E05.200.500.265', 'E05.242.223', 'E05.481.500.249'], ['D05.750.078.280.300.100', 'D12.776.860.300.250.300.100'], ['D05.750.0... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Folding of the human immunoglobulin G3 Kus core hinge into the thirteenth globular domain. | Earlier, the electron microscopy and hydrodynamic studies revealed the transformation of the globule-like form of the human (h) IgG3 Kus hinge into a rod-like shape under non-denaturing perturbations [Eur. J. Biochem. 190 (1990) 393]. In this work, it is shown with the differential scanning calorimetry (DSC) that the m... | ['Calorimetry, Differential Scanning', 'Humans', 'Immunoglobulin G', 'Models, Molecular', 'Protein Folding', 'Protein Structure, Tertiary', 'Temperature'] | 14,611,906 | [['E05.196.131.310', 'E05.196.370.310'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.124.486.485.114.619.393', 'D12.776.124.790.651.114.619.393', 'D12.776.377.715.548.114.619.393'], ['E05.599.595'], ['G01.154.651', 'G02.111.688'], ['G02.111.570.820.709.610'], ['G01.906.595', 'G16.500.275.063.725.710', 'G... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Comparative kinetics of nucleotide analog incorporation by vent DNA polymerase. | Comparative kinetic and structural analyses of a variety of polymerases have revealed both common and divergent elements of nucleotide discrimination. Although the parameters for dNTP incorporation by the hyperthermophilic archaeal Family B Vent DNA polymerase are similar to those previously derived for Family A and B ... | ['Amino Acid Sequence', 'Base Sequence', 'Binding Sites', 'Catalysis', 'DNA Primers', 'DNA-Directed DNA Polymerase', 'Kinetics', 'Molecular Sequence Data', 'Sequence Homology, Amino Acid'] | 14,699,133 | [['G02.111.570.060', 'L01.453.245.667.060'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G02.111.570.120'], ['G02.130'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['D08.811.913.696.445.308.300'], ['G01.374.661', 'G02.111.490'], ['L01.453.245.667'], ['G02.111.810.200', 'G05.810.200']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Can delirium research activity impact on routine delirium recognition? A prospective cohort study. | OBJECTIVE: To assess if ongoing delirium research activity within an acute admissions unit impacts on prevalent delirium recognition.DESIGN: Prospective cohort study.SETTING: Single-site tertiary university teaching hospital.PARTICIPANTS: 125 patients with delirium, as diagnosed by an expert using Diagnostic and Statis... | ['Aged, 80 and over', 'Biomedical Research', 'Clinical Competence', 'Delirium', 'Female', 'Hospitals, University', 'Humans', 'Male', 'Patient Admission', 'Patient Discharge', 'Prospective Studies', 'Tertiary Care Centers'] | 30,385,447 | [['M01.060.116.100.080'], ['H01.770.644.145'], ['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['C10.597.606.337.500', 'C23.888.592.604.339.500', 'F01.700.250.500', 'F03.615.350'], ['N02.278.020.300.310', 'N02.278.421.639.725'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.760.400.600', 'N02.421.585.400.60... | ['Named Groups [M]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 |
Safety signals from avoidance learning but not from yoked classical conditioning training pass both summation and retardation tests for inhibition. | In one experiment half of the animals were trained to avoid a signaled footshock by jumping (30 or 160 trials), whereas the rest of the animals received the same events as yoked. For all of them the termination of the warning signal and of the shock was followed by a safety signal. Several tests were conducted to asses... | ['Animals', 'Avoidance Learning', 'Behavior, Animal', 'Conditioning, Classical', 'Female', 'Inhibition, Psychological', 'Rats', 'Rats, Wistar', 'Teaching', 'Time Factors'] | 15,110,917 | [['B01.050'], ['F02.463.425.097', 'F02.463.785.373.173'], ['F01.145.113'], ['F02.463.425.179.308'], ['F01.145.544', 'F02.463.425.475', 'F02.739.794.405'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.900'], ['I02.903'], ['G01.910.857']] | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
Agricultural health and safety: incorporating the worker perspective. | This commentary offers a worker's perspective on agricultural health and safety and describes (1) the historical exemption of agriculture from regulatory oversight and barriers encountered due to lack of regulations and poor enforcement of the existing standards; (2) the effect of immigration status on worker protectio... | ['Accidents, Occupational', 'Agriculture', 'Emigrants and Immigrants', 'History, 20th Century', 'History, 21st Century', 'Humans', 'Occupational Exposure', 'Occupational Health', 'Organizational Case Studies', 'Safety Management', 'Transients and Migrants', 'United States', 'United States Occupational Safety and Health... | 20,665,305 | [['N06.850.135.240'], ['J01.040'], ['M01.189'], ['K01.400.504.968'], ['K01.400.504.984'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N06.850.460.350.600'], ['N01.400.525'], ['N03.349.380.710', 'N05.715.360.455'], ['N04.452.871.900', 'N06.850.135.060.075.800'], ['M01.920'], ['Z01.107.567.875'], ['I01.409.418.750... | ['Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Named Groups [M]', 'Humanities [K]', 'Organisms [B]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination. | RAG1 and RAG2 initiate V(D)J recombination, the process of rearranging the antigen-binding domain of immunoglobulins and T-cell receptors, by introducing site-specific double-strand breaks (DSB) in chromosomal DNA during lymphocyte development. These breaks are generated in two steps, nicking of one strand (hydrolysis)... | ['Amino Acid Sequence', 'Amino Acid Substitution', 'Animals', 'Binding Sites', 'CHO Cells', 'Catalysis', 'Catalytic Domain', 'Cricetinae', 'Cricetulus', 'Cysteine', 'DNA', 'DNA Nucleotidyltransferases', 'DNA-Binding Proteins', 'Gene Rearrangement', 'Homeodomain Proteins', 'Humans', 'Lymphocytes', 'Manganese', 'Molecula... | 10,601,032 | [['G02.111.570.060', 'L01.453.245.667.060'], ['E05.393.420.601.035', 'G05.558.109'], ['B01.050'], ['G02.111.570.120'], ['A11.251.210.200', 'A11.436.155'], ['G02.130'], ['G02.111.570.120.704', 'G02.111.570.820.709.275.750.188'], ['B01.050.150.900.649.313.992.635.075.250'], ['B01.050.150.900.649.313.992.635.075.250.250']... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Effect of flow and surface conditions on human lymphocyte isolation using microfluidic chambers. | Phenotypically pure subpopulations of lymphocytes can provide valuable insights into the immune response to injury and disease. The isolation of these subpopulations presents unique challenges, particularly when preprocessing incubation to attach fluorescent or antibody tags is to be minimized. This paper examines the ... | ['Antibodies', 'Avidin', 'CD5 Antigens', 'Cell Adhesion', 'Cell Line', 'Cell Separation', 'Humans', 'Lymphocytes', 'Microfluidics', 'Microscopy, Atomic Force', 'Polyethylene Glycols', 'Rheology'] | 15,595,794 | [['D12.776.124.486.485.114', 'D12.776.124.790.651.114', 'D12.776.377.715.548.114'], ['D12.776.034.614.300', 'D12.776.256.159.157.663.300', 'D12.776.290.663.100', 'D12.776.395.175'], ['D23.050.301.264.051.101', 'D23.050.301.264.894.101', 'D23.101.100.150.101', 'D23.101.100.894.101'], ['G04.022'], ['A11.251.210'], ['E01.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Interactions between scopolamine and muscarinic cholinergic agonists or cholinesterase inhibitors on spatial alternation performance in rats. | The effects on working memory of the muscarinic cholinergic agonists oxotremorine, arecoline, RS86 and pilocarpine, and the cholinesterase inhibitors physostigmine and tetrahydroaminoacadine were investigated in male F344 rats. Working memory was assessed by behavior maintained under a spatial alternation schedule of f... | ['Animals', 'Arecoline', 'Behavior, Animal', 'Cholinesterase Inhibitors', 'Dose-Response Relationship, Drug', 'Drug Interactions', 'Male', 'Memory', 'Oxotremorine', 'Parasympathomimetics', 'Physostigmine', 'Pilocarpine', 'Rats', 'Rats, Inbred F344', 'Scopolamine', 'Spatial Behavior', 'Succinimides', 'Tacrine'] | 2,262,893 | [['B01.050'], ['D03.066.515.292', 'D03.132.080', 'D03.383.725.547.292'], ['F01.145.113'], ['D27.505.519.389.275', 'D27.505.519.625.120.300', 'D27.505.696.577.120.300'], ['G07.690.773.875', 'G07.690.936.500'], ['G07.690.773.968'], ['F02.463.425.540'], ['D03.383.773.812.498'], ['D27.505.696.663.050.675'], ['D02.241.081.2... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The EMIT FreeLevel ultrafiltration technique compared with equilibrium dialysis and ultracentrifugation to determine protein binding of phenytoin. | A rapid new ultrafiltration technique (EMIT FreeLevel System I) for the routine measurement of unbound phenytoin concentrations was evaluated. The precision of this procedure was sufficient (between-days coefficient of variation, 11.7%). The results obtained by the ultrafiltration technique for the percentage of free p... | ['Adolescent', 'Adult', 'Aged', 'Blood Proteins', 'Child', 'Dialysis', 'Humans', 'Middle Aged', 'Phenytoin', 'Protein Binding', 'Ultracentrifugation', 'Ultrafiltration'] | 6,705,428 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['D12.776.124'], ['M01.060.406'], ['E05.196.353', 'G02.186'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['D03.383.129.308.432.555.730'], ['G02.111.679', 'G03.808'], ['E05.181.724', 'E05.196.941'], ['E04.292.975', 'E05.196.454.807', 'G01... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Effect of Senokot on rat intestinal electrolyte transport. Evidence of Ca++ dependence. | The mechanism of action of Senokot, a widely used laxative, has not been established. Senokot was given orally to rats 8-14 h before intestinal water and electrolyte transport were studied. Senokot significantly decreased colonic and jejunal water absorption measured in vivo by the single-pass perfusion technique. The ... | ['Adenylyl Cyclases', 'Animals', 'Biological Transport, Active', 'Calcium', 'Chlorides', 'Colon', 'Cyclic AMP', 'Intestinal Mucosa', 'Jejunum', 'Male', 'Quinacrine', 'Rats', 'Rats, Inbred Strains', 'Senna Extract', 'Sodium', 'Verapamil'] | 6,086,440 | [['D08.811.520.650.200', 'D12.644.360.050', 'D12.776.476.050'], ['B01.050'], ['G03.143.310'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D01.210.450.150', 'D01.248.497.158.215'], ['A03.556.124.526.356', 'A03.556.249.249.356'], ['D03.633.100.759.646.138.395', 'D13.695.462.200', 'D13.695.667.138.395', 'D13.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Pharmacological validation of Trypanosoma brucei phosphodiesterases as novel drug targets. | The development of drugs for neglected infectious diseases often uses parasite-specific enzymes as targets. We here demonstrate that parasite enzymes with highly conserved human homologs may represent a promising reservoir of new potential drug targets. The cyclic nucleotide-specific phosphodiesterases (PDEs) of Trypan... | ['Animals', 'Cell Proliferation', 'Drug Delivery Systems', 'Enzyme-Linked Immunosorbent Assay', 'Female', 'Gene Expression Regulation, Enzymologic', 'Mice', 'Molecular Structure', 'Phosphodiesterase Inhibitors', 'Phosphoric Diester Hydrolases', 'Pyridazines', 'Tetrazoles', 'Trypanosoma brucei brucei', 'Trypanosomiasis,... | 22,291,195 | [['B01.050'], ['G04.161.750', 'G07.345.249.410.750'], ['E02.319.300'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['G05.308.320'], ['B01.050.150.900.649.313.992.635.505.500'], ['G02.111.570', 'G02.466'], ['D27.505.519.389.735'], ['D08.811.277.352... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
'Lewy body disease': clinico-pathological correlations in 18 consecutive cases of Parkinson's disease with and without dementia. | One of the characteristic histological features of Parkinson's disease (PD), with or without dementia, is the presence of Lewy bodies (LBs) in the brainstem and neocortical and limbic structures. They are often accompanied by Alzheimer type pathology (ATP). In the present retrospective study the clinical features and p... | ['Aged', 'Aged, 80 and over', 'Alzheimer Disease', 'Brain', 'Dementia', 'Female', 'Humans', 'Lewy Bodies', 'Male', 'Mental Status Schedule', 'Neurons', 'Neuropsychological Tests', 'Organ Size', 'Parkinson Disease'] | 7,788,967 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['A08.186.211'], ['C10.228.140.380', 'F03.615.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.284.420.460'], ['F04.711.513.603.500', 'F04.711.513.653.574'], ['A08.675', 'A11.671'], ['F04.711.513']... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Alcohol mixed with energy drinks are robustly associated with patterns of problematic alcohol consumption among young adult college students. | BACKGROUND: Young adults are a population at great risk for problematic health behaviors. Alcohol mixed with energy drink (AmED) consumption is a relatively popular health risk behavior among young adults. AmED consumption continues to illustrate negative outcomes in the research literature, having been linked with oth... | ['Adolescent', 'Adult', 'Alcoholic Beverages', 'Alcoholism', 'Energy Drinks', 'Female', 'Humans', 'Male', 'Mid-Atlantic Region', 'Risk-Taking', 'Students', 'Surveys and Questionnaires', 'Young Adult'] | 25,452,057 | [['M01.060.057'], ['M01.060.116'], ['G07.203.100.100', 'J02.200.100'], ['C25.775.100.250', 'F03.900.100.350'], ['G07.203.100.512', 'J02.200.512'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.107.567.875.500'], ['F01.145.722'], ['M01.848'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980'], ['... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
Comprehensive Determination of Unregulated Pesticide Residues in Oregon Cannabis | A comprehensive multiresidue pesticide analysis for Cannabis flower matrices using quick, easy, cheap, effective, rugged, and safe (QuEChERS) sample preparation, liquid chromatography paired with triple quadrupole mass spectrometry (LC-MS/MS), and gas chromatography paired with triple quadrupole mass spectrometry (GC-M... | ['Cannabis', 'Flowers', 'Food Contamination', 'Gas Chromatography-Mass Spectrometry', 'Mass Spectrometry', 'Oregon', 'Pesticide Residues'] | 31,398,037 | [['B01.650.940.800.575.912.250.859.937.055.500'], ['A18.024.249.500'], ['J01.576.423.850.730.500.249', 'N06.850.460.400', 'N06.850.601.500.249'], ['E05.196.181.349.500', 'E05.196.566.500'], ['E05.196.566'], ['Z01.107.567.875.560.550', 'Z01.107.567.875.580.550'], ['D27.720.031.700.672', 'D27.888.723.697', 'N06.850.460.2... | ['Organisms [B]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
Age at first childbirth and oral contraceptive use are associated with risk of androgen receptor-negative breast cancer: the Malm? Diet and Cancer Cohort. | PURPOSE: Risk factors for breast cancer vary according to breast cancer subtype. This study analyzes the impact of potential risk factors in breast cancer by androgen receptor (AR) status.METHODS: A total of 17,035 women were followed in the population-based prospective Malm? Diet and Cancer Study. Baseline data includ... | ['Age Factors', 'Breast Neoplasms', 'Cohort Studies', 'Contraceptives, Oral', 'Female', 'Humans', 'Immunohistochemistry', 'Life Style', 'Middle Aged', 'Prospective Studies', 'Receptors, Androgen', 'Receptors, Estrogen', 'Receptors, Progesterone', 'Reproductive History', 'Risk Factors', 'Sweden'] | 24,825,327 | [['N05.715.350.075', 'N06.850.490.250'], ['C04.588.180', 'C17.800.090.500'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['D27.505.696.875.360.276.210', 'D27.505.954.705.360.276.210'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.51... | ['Health Care [N]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Psychiatry and Psychology [F]', 'Named Groups [M]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
Evaluating the effectiveness of the abilities-focused approach to morning care of people with dementia. | BACKGROUND AND PURPOSE: The abilities-focused approach demonstrated efficacy in promoting engagement of residents with dementia in care. The extent to which these resident outcomes can be replicated when the abilities-focused approach is implemented by nursing staff under the conditions of day-to-day practice was inves... | ['Aged', 'Aged, 80 and over', 'Dementia', 'Female', 'Geriatric Assessment', 'Geriatric Nursing', 'Humans', 'Hygiene', 'Male', 'Middle Aged', 'Nursing Assessment', 'Patient Participation', 'Patient-Centered Care', 'Psychomotor Agitation', 'Self Care', 'Toilet Facilities'] | 21,631,884 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['C10.228.140.380', 'F03.615.400'], ['E05.318.308.225', 'I01.240.425.350', 'N01.224.425.350', 'N05.715.360.300.360', 'N06.850.505.400.425.350', 'N06.850.520.308.225'], ['H02.478.676.236', 'N02.421.533.245'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.547', 'N06... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]'... | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 0 |
[Discuss on risk management of medical device production and after-production]. | By analysis on the risk management regulations and the situation of medical device after the product on the market, information list of problems and risk analysis process of the production and after-production were described, simultaneously, the suggestions were put forward to risk management after the product on the m... | ['Equipment Safety', 'Product Surveillance, Postmarketing', 'Risk Management'] | 25,330,612 | [['E05.330'], ['E05.337.800'], ['N03.219.463.800', 'N04.452.871']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
The effect of Breezy candy on halitosis: a double-blind, controlled, and randomized study. | Halitosis (bad breath) is a common condition that is socially crippling for vast parts of the population and results from malodorous volatile sulfur compounds, which are by-products of oral bacteria. In this doubled-blind, randomized study, 75 subjects with halitosis were evaluated. The participants were treated with o... | ['Adult', 'Candy', 'Double-Blind Method', 'Female', 'Gluconates', 'Halitosis', 'Humans', 'Male', 'Middle Aged', 'Propolis', 'Sulfur Compounds', 'Sweetening Agents', 'Young Adult'] | 22,532,945 | [['M01.060.116'], ['G07.203.300.140', 'J02.500.140'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['D02.241.081.844.322', 'D02.241.511.902.322', 'D09.811.308'], ['C23.888.821.475'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['D05.750.078.840.762', 'D... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Human LINE retrotransposons generate processed pseudogenes. | Long interspersed elements (LINEs) are endogenous mobile genetic elements that have dispersed and accumulated in the genomes of higher eukaryotes via germline transposition, with up to 100,000 copies in mammalian genomes. In humans, LINEs are the major source of insertional mutagenesis, being involved in both germinal ... | ['Animals', 'Cats', 'Cell Line', 'Gene Expression', 'Genes, Reporter', 'Genetic Complementation Test', 'Genetic Vectors', 'Humans', 'Long Interspersed Nucleotide Elements', 'Mutagenesis, Site-Directed', 'Open Reading Frames', 'Polymerase Chain Reaction', 'Pseudogenes', 'RNA, Messenger', 'Recombination, Genetic', 'Retro... | 10,742,098 | [['B01.050'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['A11.251.210'], ['G05.297'], ['G05.360.340.024.340.435'], ['E05.393.281.526'], ['G05.360.337'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.111.570.080.708.330.800.400', 'G05.360.080.708.330.800.400', 'G05.360.340.024.425.800.400'], ['E05.393.42... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A simple and safe operation method for brachiocephalic artery aneurysms. | A 64-year-old man was referred to our hospital due to dyspnea and fever. The chest computed tomogram revealed a 60-mm aneurysm of the brachiocephalic artery with mural thrombus. The aneurysm of the brachiocephalic artery and the right subclavian artery were exposed through only median sternotomy. Cardiopulmonary bypass... | ['Aneurysm', 'Brachiocephalic Trunk', 'Cardiopulmonary Bypass', 'Cerebrovascular Circulation', 'Humans', 'Male', 'Middle Aged', 'Tomography, X-Ray Computed'] | 18,384,572 | [['C14.907.055'], ['A07.015.114.145'], ['E04.292.413'], ['G09.330.100.159'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.370.350.350.810', 'E01.370.350.600.350.700.810', 'E01.370.350.700.700.810', 'E01.370.350.700.810.810', 'E01.370.350.825.810.810']] | ['Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Named Groups [M]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Arformoterol and salmeterol in the treatment of chronic obstructive pulmonary disease: a one year evaluation of safety and tolerance. | INTRODUCTION: Concerns have been raised regarding the safety of extended use of long-acting beta2-agonists (LABAs). The safety of arformoterol (50 microg QD), and salmeterol (42 microg BID), was assessed over 12 months in subjects with COPD. The study also examined the occurrence of tolerance with these agents, i.e. wh... | ['Albuterol', 'Arrhythmias, Cardiac', 'Bronchitis', 'Bronchodilator Agents', 'Ethanolamines', 'Female', 'Forced Expiratory Volume', 'Formoterol Fumarate', 'Humans', 'Ipratropium', 'Male', 'Middle Aged', 'Myocardial Ischemia', 'Nebulizers and Vaporizers', 'Prospective Studies', 'Pulmonary Disease, Chronic Obstructive', ... | 19,124,357 | [['D02.033.100.291.057', 'D02.092.063.291.057', 'D02.092.471.683.061'], ['C14.280.067', 'C23.550.073'], ['C01.748.099', 'C08.127.446', 'C08.381.495.146', 'C08.730.099'], ['D27.505.696.663.050.110', 'D27.505.954.796.050.100'], ['D02.033.100.291', 'D02.033.375.291', 'D02.092.063.291'], ['E01.370.386.700.660.230', 'G09.77... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Named Groups [M]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Human skin-derived fibroblasts acquire in vitro anti-tumor potential after priming with Paclitaxel. | The main goal in cancer chemotherapy is to drive the drug into the tumor microenvironment to kill as many cancer cells as possible while producing the lowest collateral toxicity. Previously, we have shown that human bone marrow derived mesenchymal stromal cells (hBM-MSCs) exposed to Paclitaxel (PTX) were able to uptake... | ['Antineoplastic Agents', 'Biological Transport', 'Cell Cycle', 'Cell Line, Tumor', 'Cell Proliferation', 'Cell Survival', 'Coculture Techniques', 'Culture Media, Conditioned', 'Delayed-Action Preparations', 'Fibroblasts', 'Humans', 'Paclitaxel', 'Skin', 'Tumor Microenvironment'] | 22,931,415 | [['D27.505.954.248'], ['G03.143'], ['G04.144'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.161.750', 'G07.345.249.410.750'], ['G04.346'], ['E05.481.500.374'], ['D27.720.470.305.250', 'E07.206.250'], ['D26.255.210', 'E02.319.300.253'], ['A11.329.228'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.455.426.39... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A classification of essential hypertensive patients according to the erythrocyte Na transport abnormalities: an application for monitoring the antihypertensive response to cicletanide. | We have studied the kinetic properties of the interaction of internal Na with four different Na transport pathways (ouabain-sensitive Na, K pump, bumetanide-sensitive Na,K cotransport, Li:Na countertransport and passive Na permeability) in erythrocytes from 197 essential hypertensive patients. This study permitted us t... | ['Adult', 'Aged', 'Antihypertensive Agents', 'Biological Transport', 'Diuretics', 'Erythrocytes', 'Female', 'Humans', 'Hypertension', 'Ion Channels', 'Lithium', 'Male', 'Middle Aged', 'Potassium', 'Pyridines', 'Sodium'] | 2,582,180 | [['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.411.162'], ['G03.143'], ['D27.505.696.560.500'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['D12.776.157.530.400', 'D12.776.543.550.450', 'D12.776.543.585.400'], ['D01.268.549.450', 'D01.268.5... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Catalytic role of monovalent cations in the mechanism of proton transfer which gates an interprotein electron transfer reaction. | Within the methylamine dehydrogenase (MADH)-amicyanin protein complex, long range intermolecular electron transfer (ET) occurs between tryptophan tryptophylquinone (TTQ) of MADH and the type I copper of amicyanin. The reoxidations of two chemically distinct reduced forms of TTQ were studied, a quinol (O-quinol) generat... | ['Bacterial Proteins', 'Catalysis', 'Cations, Monovalent', 'Electron Transport', 'Hydroquinones', 'Kinetics', 'Oxidoreductases Acting on CH-NH Group Donors', 'Paracoccus denitrificans', 'Protons', 'Solvents'] | 9,354,627 | [['D12.776.097'], ['G02.130'], ['D01.248.497.300.459'], ['G02.111.248', 'G03.295.531.403', 'G03.493.350'], ['D02.455.426.559.389.657.393'], ['G01.374.661', 'G02.111.490'], ['D08.811.682.662'], ['B03.440.400.425.600.380', 'B03.660.050.750.600.125'], ['D01.248.497.300.459.700', 'D01.268.406.750', 'D01.362.340.750', 'G01.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Four new species of Cichlidogyrus (Monogenea, Ancyrocephalidae) from Sarotherodon mvogoi and Tylochromis sudanensis (Teleostei, Cichlidae) in Cameroon. | The four Cichlidogyrus species (Monogenea, Ancyrocephalidae) found on the gills of Sarotherodon mvogoi and Tylochromis sudanensis (Teleostei, Cichlidae) in Cameroon are considered new and are described herein. Cichlidogyrus mvogoi n. sp. from Sarotherodon mvogoi, characterised by a long (> 100 µm), thin and spirally co... | ['Animal Distribution', 'Animals', 'Cameroon', 'Cichlids', 'Male', 'Trematoda'] | 25,543,634 | [['F01.145.113.069', 'G16.049'], ['B01.050'], ['Z01.058.290.100.110'], ['B01.050.150.900.493.602.200'], ['B01.050.500.500.736.715']] | ['Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Adaptation of the AACN Synergy Model for Patient Care to critical care transport. | Today's health care delivery system relies heavily on interhospital transfer of patients who require higher levels of care. Although numerous tools and algorithms have been used for the prehospital determination of mode of transport, no tool for the transfer of patients between hospitals has been widely accepted. Typic... | ['Critical Care', 'Models, Nursing', 'Patient Transfer'] | 24,488,887 | [['E02.760.190', 'N02.421.585.190'], ['E05.599.645'], ['E02.760.169.624', 'E02.760.400.630', 'N02.421.585.169.624', 'N02.421.585.400.630', 'N04.590.233.727.210.624']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
There is hope for the future: national survey results reveal that geriatric medicine fellows are well-educated in end-of-life care. | OBJECTIVES: To assess the status of geriatric medicine (GM) fellows' training experiences in end-of-life care via self-report.DESIGN: Anonymous surveys completed by mail, Web access, and telephone.SETTING: U.S. accredited GM fellowship training programs.PARTICIPANTS: Two hundred ninety-six surveys were sent to graduati... | ['Adult', 'Aged', 'Clinical Competence', 'Curriculum', 'Education, Medical, Graduate', 'Fellowships and Scholarships', 'Female', 'Geriatrics', 'Humans', 'Male', 'Palliative Care', 'Program Evaluation', 'Terminal Care', 'United States'] | 15,817,021 | [['M01.060.116'], ['M01.060.116.100'], ['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['I02.158'], ['I02.358.337.350', 'I02.358.399.350'], ['N03.219.483.838.276'], ['H02.403.355'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.760.666', 'N02.421.585.666'], ['E05.337.820', 'N04.761.685', 'N05.715.360.650'],... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Management of a rare presentation of Vogt-Koyanagi-Harada disease in human immunodeficiency virus/acquired immunodeficiency disease syndrome patient. | Vogt-Koyanagi-Harada (VKH), a multisystem autoimmune bilateral panuveitis with systemic manifestations, is uncommon in immunocompromised patients such as human immunodeficiency virus (HIV)/acquired immunodeficiency disease syndrome (AIDS). We report a rare presentation of VKH in a 45-year-old HIV-positive female on hig... | ['Acquired Immunodeficiency Syndrome', 'Female', 'Glucocorticoids', 'HIV', 'Humans', 'Middle Aged', 'Ophthalmologic Surgical Procedures', 'Panuveitis', 'Uveomeningoencephalitic Syndrome'] | 28,574,002 | [['C01.221.250.875.040', 'C01.221.812.640.400.040', 'C01.778.640.400.040', 'C01.925.782.815.616.400.040', 'C01.925.813.400.040', 'C01.925.839.040', 'C20.673.480.040'], ['D06.472.040.543', 'D27.505.696.399.472.488'], ['B04.820.650.589.650.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E04... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Impurity profiling of varenicline tartrate by LC-QTOF mass spectrometric techniques during drug development. | An LC-QTOF-MS method was developed for the separation and characterization of related substances in varenicline tartrate. The separation was established on an InertSustain C18 column (4.6 mm ? 150 mm, 5 ìm) by liner gradient elution using 0.05% trifluoroacetic acid as mobile phase A and acetonitrile as mobile phase B. ... | ['Chromatography, High Pressure Liquid', 'Drug Discovery', 'Drug Stability', 'Oxidation-Reduction', 'Photolysis', 'Spectrometry, Mass, Electrospray Ionization', 'Tandem Mass Spectrometry', 'Varenicline'] | 29,679,875 | [['E05.196.181.400.300'], ['E05.295', 'H01.158.703.007.675', 'H01.181.466.675'], ['E05.916.330'], ['G02.700', 'G03.295.531'], ['G02.740.685'], ['E05.196.566.600'], ['E05.196.566.880'], ['D03.633.100.079.900', 'D03.633.100.857.942']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Influence of lithium on cyclic AMP accumulation in isolated rat fat cells. | Lithium inhibits in vitro as well as in vivo several hormone-stimulated adenylate cyclases. The aim of this study was to investigate the mechanism by which lithium inhibits adenylate cyclase in vitro. It was found that lithium inhibited both the norepinephrine- and the glucagon-induced cAMP accumulation in rat fat cell... | ['Adenylyl Cyclase Inhibitors', 'Adipose Tissue', 'Animals', 'Cyclic AMP', 'Dose-Response Relationship, Drug', 'Glucagon', 'Lithium', 'Norepinephrine', 'Propranolol', 'Rats', 'Receptors, Cell Surface', 'Time Factors'] | 231,891 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The need for global certification in the field of health informatics: some ethical issues. | In the past, the training of health information professionals (HIPs) has focussed almost exclusively on technical matters, the concerns of software developers and purveyors have essentially centred on security and functionality, and health care providers have mainly worried about costs and efficiency. This paper outlin... | ['Certification', 'Codes of Ethics', 'Confidentiality', 'Informatics', 'Organizations', 'Security Measures', 'United States'] | 17,911,713 | [['N03.706.110.120', 'N05.700.200.190'], ['K01.752.566.479.068', 'K01.752.566.479.171.066', 'N04.761.700.350.324', 'N05.350.213', 'N05.350.340.080', 'N05.700.350.324'], ['F04.096.544.335.240', 'I01.880.604.473.650.500', 'I01.880.604.583.080', 'N03.706.437.650.124', 'N03.706.535.230'], ['L01.313'], ['N03.540'], ['N04.45... | ['Health Care [N]', 'Humanities [K]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Information Science [L]', 'Geographicals [Z]'] | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 1 |
[Simultaneous determination of seven sexual hormones in essential oil by high performance liquid chromatography with diode array and fluorescence detectors]. | An efficient method for analyzing seven sexual hormones (estradiol-17beta, estriol, estrone, testosterone, methyl-testosterone, progesterone and diethylstilbestrol) in essential oil by high performance liquid chromatography was developed. The samples were dissolved in n-hexane, then extracted with 90% methanol solution... | ['Chromatography, High Pressure Liquid', 'Diethylstilbestrol', 'Estradiol', 'Fluorescence', 'Gonadal Steroid Hormones', 'Oils, Volatile', 'Spectrometry, Fluorescence', 'Testosterone'] | 19,803,139 | [['E05.196.181.400.300'], ['D02.455.426.559.389.150.700.725.500'], ['D04.210.500.365.415.248', 'D06.472.334.851.437.500'], ['G01.358.500.505.650.665.500', 'G01.590.540.665.500'], ['D06.472.334.851'], ['D10.627.675'], ['E05.196.712.516.600.676', 'E05.196.867.726'], ['D04.210.500.054.079.429.824', 'D06.472.334.851.968.98... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Ocular manifestations in patients with human immunodeficiency virus infection before and after the introduction of highly active antiretroviral therapy]. | The aim of this study was to determine and compare the incidence of various ophthalmlogic changes before anfd after the initiation of highly active antiretroviral therapy (HAART) in HIV-infected patients treated at the University Hospital for Infectious Diseases "Dr. Fran Mihaljevi?" in Zagreb. This retrospective longi... | ['AIDS-Related Opportunistic Infections', 'Adult', 'Antiretroviral Therapy, Highly Active', 'Cytomegalovirus Retinitis', 'Eye Diseases', 'Female', 'HIV Infections', 'HIV-1', 'Humans', 'Male', 'Middle Aged'] | 16,281,473 | [['C01.221.250.875.100', 'C01.597.050', 'C01.610.684.050', 'C01.925.597.050', 'C01.925.782.815.616.400.100', 'C20.673.480.100'], ['M01.060.116'], ['E02.319.310.075'], ['C01.375.725.270', 'C01.925.256.466.245.150', 'C01.925.325.270', 'C11.294.800.270', 'C11.768.773.360'], ['C11'], ['C01.221.250.875', 'C01.221.812.640.40... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Modified lateral block of the suprascapular nerve: a safe approach and how much to inject? A morphological study. | BACKGROUND AND OBJECTIVES: This paper presents an evaluation of a modified lateral suprascapular nerve block with easy orientation, low risk of displacement of the needle, and with an assessment of 2 different volumes to propose an ideal volume for a successful block.METHODS: Both shoulders of 34 cadavers were investig... | ['Adult', 'Aged', 'Aged, 80 and over', 'Analysis of Variance', 'Anesthetics, Local', 'Cadaver', 'Female', 'Humans', 'Image Processing, Computer-Assisted', 'Male', 'Middle Aged', 'Nerve Block', 'Peripheral Nerves', 'Scapula', 'Shoulder', 'Skin', 'Tomography, X-Ray Computed'] | 18,035,294 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['D27.505.696.277.100.200', 'D27.505.696.663.850.025', 'D27.505.954.427.210.100.200'], ['C23.550.260.224'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['M01.060.116.6... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Information Science [L]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
A novel FBN1 heterozygous mutation identified in a Chinese family with autosomal dominant Marfan syndrome. | The purpose of this study was to identify the clinical features and mutations in the fibrillin-1 gene (FBN1) in a large Chinese family with autosomal dominant Marfan syndrome (MFS). Seventeen members from a Chinese family of 4 generations were included in the study. All members underwent complete ophthalmic examination... | ['Adolescent', 'Adult', 'Aged', 'Amino Acid Substitution', 'Asian Continental Ancestry Group', 'Base Sequence', 'Child', 'DNA Mutational Analysis', 'Ectopia Lentis', 'Exons', 'Female', 'Fibrillin-1', 'Fibrillins', 'Genotype', 'Heterozygote', 'Humans', 'Male', 'Marfan Syndrome', 'Middle Aged', 'Mutation, Missense', 'Seq... | 25,966,184 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['E05.393.420.601.035', 'G05.558.109'], ['M01.686.508.200'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['M01.060.406'], ['E05.393.760.700.300'], ['C11.250.300', 'C11.510.598.373', 'C16.131.384.405'], ['G05.360.340.024.340.137.232'], ['D09.400.430.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Works in progress #2. Threaded acetabular components. Design rationale and preliminary clinical experience. | Two design rationales for threaded acetabular components, the S-ROM Anderson cup and S-ROM SuperCup, are discussed. Components have been followed for at least six months, with a range of six to 24 months. The average follow up is nine months. One hundred components in 96 patients had sufficient follow up and full clini... | ['Acetabulum', 'Adult', 'Aged', 'Female', 'Follow-Up Studies', 'Hip Joint', 'Hip Prosthesis', 'Humans', 'Male', 'Middle Aged', 'Prosthesis Design', 'Radiography'] | 3,174,210 | [['A02.835.232.043.825.108'], ['M01.060.116'], ['M01.060.116.100'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['A02.835.583.411'], ['E07.695.400.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.320.550', 'E07.695.680'], ['E01.370.350.700... | ['Anatomy [A]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Effects of Apocynum hendersonii (Hook. f.) Woodson on cardiac electric and mechanical activity]. | Calcium antagonist-like effect of Apocynum hendersonii on myocardiac preparations was observed in the present experiments. The action potential duration and contractility were decreased. Automatic or exciting activity in partially depolarized fibers was considerably inhibited or concealed. Observation in vivo showed th... | ['Action Potentials', 'Animals', 'Bundle of His', 'Depression, Chemical', 'Drugs, Chinese Herbal', 'Electrocardiography', 'Female', 'Guinea Pigs', 'Heart', 'In Vitro Techniques', 'Male', 'Myocardial Contraction', 'Purkinje Fibers', 'Rabbits'] | 2,506,895 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['B01.050'], ['A07.541.409.273'], ['G07.690.773.750'], ['D20.215.784.500.350', 'D26.335'], ['E01.370.370.380.240', 'E01.370.405.240'], ['B01.050.150.900.649.313.992.550'], ['A07.541'], ['E05.481'], ['G09.330.580', 'G11.427.494.570'], ['A07.541.409.683'], ['B01.050... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Role of caspases in human renal proximal tubular epithelial cell apoptosis. | In the present study, we have used an in vitro model of apoptosis using primary human renal proximal tubular epithelial (RPTE) cells to investigate the mechanisms involved in renal cell apoptosis. Treatment of RPTE cells with okadaic acid for 24-48 h induced apoptosis in a concentration-dependent manner. Apoptosis was ... | ['Amino Acid Chloromethyl Ketones', 'Apoptosis', 'Caspases', 'Cytoskeletal Proteins', 'Humans', 'Kidney Tubules, Proximal', 'Mitogen-Activated Protein Kinases', 'Okadaic Acid', 'Oligopeptides', 'Trans-Activators', 'beta Catenin', 'p38 Mitogen-Activated Protein Kinases'] | 11,755,144 | [['D12.125.065'], ['G04.146.954.035'], ['D08.811.277.656.262.500.126', 'D08.811.277.656.300.200.126', 'D12.644.360.075.405', 'D12.776.476.075.405'], ['D12.776.220'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A05.810.453.736.560.570'], ['D08.811.913.696.620.682.700.567', 'D12.644.360.450', 'D12.776.476.450'], [... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Clostridium aldrichii sp. nov., a cellulolytic mesophile inhabiting a wood-fermenting anaerobic digester. | An anaerobic, mesophilic, spore-forming, cellulolytic bacterium was repeatedly isolated from a wood-fermenting anaerobic digester. Cells of this organism were gram-positive rods, motile with a bundle of polar flagella, and formed subterminal oblong spores. The colonies in agar had an irregular shape with many platelike... | ['Bacteria, Anaerobic', 'Base Composition', 'Biodegradation, Environmental', 'Clostridium', 'DNA, Bacterial', 'Fermentation'] | 2,397,194 | [['B03.130'], ['G02.111.080'], ['N06.230.080.600.500', 'N06.850.460.375.500'], ['B03.300.390.400.200', 'B03.353.625.375.500', 'B03.510.415.400.200'], ['D13.444.308.212'], ['G02.111.158.249', 'G03.191.249']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Genome analysis of two novel Pseudomonas strains exhibiting differential hypersensitivity reactions on tobacco seedlings reveals differences in nonflagellar T3SS organization and predicted effector proteins. | Multilocus sequence analysis (MLSA) of two new biological control strains (S1E40 and S3E12) of Pseudomonas was performed to assess their taxonomic position relative to close lineages, and comparative genomics employed to investigate whether these strains differ in key genetic features involved in hypersensitivity respo... | ['Biofilms', 'DNA Gyrase', 'DNA, Bacterial', 'DNA-Directed RNA Polymerases', 'Flagella', 'Genome, Bacterial', 'Multilocus Sequence Typing', 'Phylogeny', 'Plant Diseases', 'Pseudomonas', 'RNA, Ribosomal, 16S', 'Seedlings', 'Sequence Analysis, DNA', 'Sigma Factor', 'Tobacco', 'Type III Secretion Systems'] | 29,464,939 | [['A20.593', 'G06.120'], ['D08.811.399.403.741.149', 'D12.776.097.237'], ['D13.444.308.212'], ['D08.811.913.696.445.735.270'], ['A11.284.180.290'], ['G05.360.340.358.207'], ['E01.370.225.875.150.125.457.500', 'E05.200.875.150.125.457.500', 'E05.393.542.500', 'E05.393.760.700.650'], ['G05.697', 'G16.075.605', 'L01.100.6... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Effect of tannic acid on brush border disaccharidases in mammalian intestine. | Tannic acid is a glucoside (penta-m-digallolyl-glucose), which exhibits a wide variety of physiological functions. Around neutral pH, 0.4 mM tannic acid produced 84% inhibition of rat brush border sucrase activity, but 35-40% enzyme inhibition was observed in the rabbit intestine at 0.08 mM concentration. In the mice, ... | ['Animals', 'Disaccharidases', 'Intestines', 'Mice', 'Mice, Inbred BALB C', 'Microvilli', 'Rabbits', 'Rats', 'Rats, Wistar', 'Tannins'] | 17,477,307 | [['B01.050'], ['D08.811.277.450.329'], ['A03.556.124'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.338', 'B01.050.150.900.649.313.992.635.505.500.400.338'], ['A11.284.180.565'], ['B01.050.150.900.649.313.968.700'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.63... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Intraoperative neuromonitoring for function-guided resection differs for supratentorial motor eloquent gliomas and metastases. | BACKGROUND: Recent data show differences in intraoperative neuromonitoring (IOM) in relation to the operated brain lesion. Due to the recently shown infiltrative nature of cerebral metastases, this work investigates the differences of IOM for cerebral metastases and glioma resection concerning sensitivity, specificity,... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Brain Neoplasms', 'Cohort Studies', 'Evoked Potentials, Motor', 'Female', 'Glioma', 'Humans', 'Intraoperative Neurophysiological Monitoring', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Monitoring, Intraoperative', 'Motor Cortex', 'Neoplasm, Residual', 'Pa... | 26,487,091 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['G07.265.216.500.385', 'G11.561.200.500.385'], ['C04.557.465.625.600.380', 'C04.557.470.670.380'... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Referral bias in hospital register studies of geographical and industrial differences in health. | INTRODUCTION: The Danish National Hospital Register contains four patient types: full-time inpatients, part-time inpatients, outpatients and emergency ward patients. The aim of the present study was to investigate whether results from comparative hospital register studies depend on which patient types we choose to incl... | ['Adult', 'Day Care, Medical', 'Denmark', 'Hospitalization', 'Humans', 'Inpatients', 'Middle Aged', 'Occupational Diseases', 'Occupational Health Services', 'Outpatients', 'Referral and Consultation', 'Registries'] | 16,009,057 | [['M01.060.116'], ['E02.760.246', 'N02.421.585.246'], ['Z01.542.816.124'], ['E02.760.400', 'N02.421.585.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.643.470'], ['M01.060.116.630'], ['C24'], ['N02.421.143.740'], ['M01.643.630'], ['N04.452.758.849'], ['E05.318.308.970', 'N04.452.859.819', 'N05.715.360.30... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Differential expression of perforin in muscle-infiltrating T cells in polymyositis and dermatomyositis. | Polymyositis (PM) and dermatomyositis (DM) are the prototypical inflammatory diseases of skeletal muscle. In PM, CD8+ T cells invade and destroy muscle fibers, whereas humoral effector mechanisms prevail in DM. We studied the expression of the cytotoxic mediator perforin in inflammatory cells in PM and DM muscle by sem... | ['Base Sequence', 'Dermatomyositis', 'Humans', 'Membrane Glycoproteins', 'Molecular Sequence Data', 'Muscles', 'Perforin', 'Polymerase Chain Reaction', 'Polymyositis', 'Pore Forming Cytotoxic Proteins', 'T-Lymphocytes'] | 8,675,705 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['C05.651.594.819.500', 'C10.668.491.562.575.500', 'C17.300.250', 'C17.800.185'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.395.550', 'D12.776.543.550'], ['L01.453.245.667'], ['A02.633', 'A10.690'], ['D12.776.543.695.875'], ['E05.393.620.500']... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Exploring the fMRI based neural correlates of the dot probe task and its modulation by sex and body odor. | The dot probe task implicitly cues attention via emotional information, an effect which is especially pronounced for threat-related cues. However, several questions remain unexplored. The first one is whether chemosignals like the androgen-derivative androstadienone can influence such attentional biases. Second, few st... | ['Adult', 'Androstadienes', 'Attention', 'Attentional Bias', 'Cues', 'Emotional Intelligence', 'Emotions', 'Facial Expression', 'Facial Recognition', 'Female', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Odorants', 'Olfactory Perception', 'Sex Factors', 'Young Adult'] | 30,216,766 | [['M01.060.116'], ['D04.210.500.054.079.129'], ['F02.830.104.214'], ['F02.830.104.214.500'], ['F02.463.425.234'], ['F01.752.543.500'], ['F01.470'], ['E01.370.600.225', 'F01.145.209.530.385'], ['F02.463.593.524.250.500', 'F02.463.593.524.500.500', 'F02.463.593.932.622.500'], ['B01.050.150.900.649.313.988.400.112.400.400... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Increased platelet aggregation in early diabetus mellitus. | In view of the tendency toward vascular disease in diabetes mellitus, we studied platelet aggregation in 15 normal, 7 prediabetic, 12 latent, and 20 frankly diabetic subjects. Platelets from latent and frank diabetics showed increased platelet aggregation 4 minutes after adding adenosine 5'-diphosphate (60% verus 29% a... | ['Adenosine Diphosphate', 'Administration, Oral', 'Aspirin', 'Collagen', 'Diabetes Mellitus', 'Diabetic Angiopathies', 'Epinephrine', 'Glucose', 'Glucose Tolerance Test', 'Humans', 'In Vitro Techniques', 'Platelet Adhesiveness', 'Platelet Aggregation', 'Prediabetic State', 'Time Factors', 'Tolbutamide'] | 1,138,583 | [['D03.633.100.759.646.138.124', 'D13.695.667.138.124', 'D13.695.827.068.124'], ['E02.319.267.100'], ['D02.455.426.559.389.657.410.595.176'], ['D05.750.078.280', 'D12.776.860.300.250'], ['C18.452.394.750', 'C19.246'], ['C14.907.320', 'C19.246.099.500'], ['D02.033.100.291.310', 'D02.092.063.291.310', 'D02.092.211.215.45... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Effect of flumazenil on hypoglossal and phrenic nerves activities in rabbits]. | BACKGROUND: Upper airway obstruction and inadequate ventilation often arise during sedation and anesthesia by benzodiazepines (Bz). Flumazenil antagonizes these effects of active benzodiazepines on the central nervous system. To estimate the influence of flumazenil on the endogenous Bz system related respiratory contro... | ['Action Potentials', 'Animals', 'Benzodiazepines', 'Diazepam', 'Flumazenil', 'Hypoglossal Nerve', 'Male', 'Phrenic Nerve', 'Rabbits', 'Respiration'] | 15,298,241 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['B01.050'], ['D03.633.100.079.080'], ['D03.633.100.079.080.070.216'], ['D03.633.100.079.080.070.305'], ['A08.800.800.120.330'], ['A08.800.800.720.150.700'], ['B01.050.150.900.649.313.968.700'], ['G09.772.705']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A community rheumatology practice offers an educational experience comparable to that of a university tertiary care center. | OBJECTIVE: To compare the teaching value of rheumatology patients seen in either a community rheumatology practice or in a tertiary care university center.METHODS: Consecutive patients seen at the 2 sites over a one month period were assessed for rheumatology diagnosis, complexity of rheumatologic disease, and treatmen... | ['Community Health Services', 'Female', 'Hospitals, University', 'Humans', 'Male', 'Middle Aged', 'Rheumatology', 'Teaching'] | 11,128,683 | [['N02.421.143'], ['N02.278.020.300.310', 'N02.278.421.639.725'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['H02.403.429.730'], ['I02.903']] | ['Health Care [N]', 'Organisms [B]', 'Named Groups [M]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 |
Multi-modal distraction. Using technology to combat pain in young children with burn injuries. | BACKGROUND: The use of non-pharmacological pain management remains adhoc within acute paediatric burns pain management protocols despite ongoing acknowledgement of its role. Advancements in adult based pain services including the integration of virtual reality has been adapted to meet the needs of children in pain, as ... | ['Adult', 'Analgesia', 'Analysis of Variance', 'Attention', 'Bandages', 'Burns', 'Child', 'Child, Preschool', 'Female', 'Humans', 'Male', 'Pain', 'Pain Management', 'Pain Measurement', 'Pediatrics', 'Prospective Studies', 'User-Computer Interface', 'Video Games'] | 19,889,502 | [['M01.060.116'], ['E03.091'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['F02.830.104.214'], ['E07.101'], ['C26.200'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.888.592.612', 'F02.830.816.444', 'G11.561.790.444'], ['E02.745', 'N04.590.607.500'... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Information Science [L]', 'Anthropology, Education, Sociology, and Social P... | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 |
Short communication: Daily intake of 125 g of cheese for 2 weeks did not alter amount or distribution of serum lipids or desaturase indexes in healthy adults in an exploratory pilot study. | Regular cheese contains saturated fat, consumption of which may negatively influence the amount of serum lipids. The American Dietary Guidelines (https://health.gov/dietaryguidelines/2015/guidelines/) recommend consumption of low-fat food. However, we observed a negative association between cheese intake and serum trig... | ['Adult', 'Cheese', 'Cholesterol', 'Cholesterol, HDL', 'Cholesterol, LDL', 'Cross-Over Studies', 'Diet', 'Dietary Fats', 'Fatty Acid Desaturases', 'Fatty Acids', 'Female', 'Humans', 'Lipids', 'Male', 'Metabolic Syndrome', 'Middle Aged', 'Pilot Projects', 'Risk Factors', 'Triglycerides'] | 30,146,282 | [['M01.060.116'], ['G07.203.200.500.444', 'G07.203.300.350.300.444', 'J02.350.500.444', 'J02.500.350.300.444'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['D04.210.500.247.808.197.238', 'D10.532.432.400', 'D10.570.938.208.270', 'D12.776.521.479.470'], ['D04.210.500.247.808.197.244', 'D1... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Axial length changes accompanying successful nonpenetrating glaucoma filtration surgery. | We aimed to evaluate the effect of nonpenetrating glaucoma filtration surgery on axial length (AL). Thirty patients (30 eyes) who underwent successful nonpenetrating glaucoma filtration surgery were prospectively analyzed. AL was measured preoperatively and postoperatively at 1 and 12 months. Associations between chang... | ['Adult', 'Aged', 'Aged, 80 and over', 'Female', 'Glaucoma', 'Glaucoma Drainage Implants', 'Humans', 'Intraocular Pressure', 'Male', 'Middle Aged', 'Postoperative Complications', 'Postoperative Period', 'Refractive Errors', 'Regression Analysis', 'Retrospective Studies', 'Trabeculectomy', 'Treatment Outcome', 'Visual A... | 12,660,483 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C11.525.381'], ['E07.695.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G14.440'], ['M01.060.116.630'], ['C23.550.767'], ['E04.614.750', 'N02.421.585.753.750'], ['C11.744'], ['E05.318.740.750', 'N05.715.360.750.695', 'N06.850.520.830.750'], ['... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Distinct intraspecific variations of garlic (Allium sativum L.) revealed by the exon-intron sequences of the alliinase gene. | Garlic (Allium sativum L.) has been used worldwide as a food and for medicinal purposes since early times. Garlic cultivars exhibit considerable morphological diversity despite the fact that they are mostly sterile and are grown only by vegetative propagation of cloves. Considerable recombination occurs in garlic genom... | ['Base Sequence', 'Carbon-Sulfur Lyases', 'Exons', 'Garlic', 'Genetic Variation', 'Haplotypes', 'Introns'] | 24,352,587 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D08.811.520.300'], ['G05.360.340.024.340.137.232'], ['B01.650.940.800.575.912.250.618.100.050.060.300'], ['G05.365'], ['G05.380.360'], ['G05.360.340.024.220.400', 'G05.360.340.024.340.137.515']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Prenatal diagnosis: a directive approach to genetic counseling using decision analysis. | The decision which prospective parents face concerning mid-trimester amniocentesis for prenatal diagnosis was examined by decision analysis. The prospective parents' decision depends on the likelihood of the birth of a child affected by a genetic disorder, the risk of amniocentesis, and the probability that the diagnos... | ['Decision Making', 'Down Syndrome', 'Female', 'Genetic Counseling', 'Humans', 'Meningomyelocele', 'Muscular Dystrophies', 'Prenatal Diagnosis'] | 142,379 | [['F02.463.785.373'], ['C10.597.606.360.220', 'C16.131.077.327', 'C16.131.260.260', 'C16.320.180.260'], ['H01.158.273.343.385.500.384', 'N02.421.308.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.500.680.610', 'C16.131.666.680.610'], ['C05.651.534.500', 'C10.668.491.175.500', 'C16.320.577'], ['E01.370.37... | ['Psychiatry and Psychology [F]', 'Diseases [C]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
A tentorial sling in microvascular decompression for trigeminal neuralgia. Technical note. | The key to the successful microvascular decompression of the trigeminal nerve is the maintenance of the separation between the trigeminal nerve and the offending vessel. The authors describe a technique whereby a dural sling is fashioned from the tentorium cerebelli (the anatomy of which is briefly reviewed), which is ... | ['Cerebellum', 'Constriction', 'Humans', 'Microcirculation', 'Trigeminal Neuralgia'] | 8,613,820 | [['A08.186.211.132.810.428.200'], ['E05.225'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G09.330.100.645'], ['C07.465.299.625.500.700', 'C10.292.319.625.700.700']] | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Inhibition of DNA synthesis in murine tumor cells by geldanamycin, an antibiotic of the benzoquinoid ansamycin group. | The mechanism of action of geldanamycin, a benzoquinoid ansamycin, was investigated with murine lymphoblastoma L5178Y cells. The agent inhibited the cell growth at concentrations over 0.01 micrograms/ml. The antibiotic blocked DNA synthesis more markedly than RNA and protein syntheses. Mitosis was not significantly aff... | ['Animals', 'Antibiotics, Antineoplastic', 'Benzoquinones', 'Carcinoma, Ehrlich Tumor', 'Cell Division', 'Cells, Cultured', 'DNA, Neoplasm', 'Depression, Chemical', 'Lactams, Macrocyclic', 'Lymphoma, Non-Hodgkin', 'Macromolecular Substances', 'Mice', 'Neoplasm Proteins', 'Nucleic Acid Synthesis Inhibitors', 'Quinones',... | 6,897,401 | [['B01.050'], ['D27.505.954.248.106'], ['D02.806.250'], ['C04.557.470.200.200', 'C04.619.169'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.251'], ['D13.444.308.425'], ['G07.690.773.750'], ['D02.065.589.327', 'D04.345.295'], ['C04.557.386.480', 'C15.604.515.569.480', 'C20.683.515.761... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
In vivo study of transepithelial potential difference (TEPD) in proximal convoluted tubules of rat kidney by synchronization modulation electric field. | Synchronization modulation (SM) electric field has been shown to effectively activate function of Na(+)/K(+) pumps in various cells and tissues, including skeletal muscle cells, cardiomyocyte, monolayer of cultured cell line, and peripheral blood vessels. We are now reporting the in vivo studies in application of the S... | ['Animals', 'Ion Transport', 'Kidney Tubules, Proximal', 'Membrane Potentials', 'Microelectrodes', 'Rats', 'Sodium-Potassium-Exchanging ATPase'] | 24,894,719 | [['B01.050'], ['G03.143.500'], ['A05.810.453.736.560.570'], ['G01.154.535', 'G04.580', 'G07.265.675', 'G11.561.570'], ['E07.305.250.500'], ['B01.050.150.900.649.313.992.635.505.700'], ['D08.811.277.040.025.314.750', 'D12.776.157.530.450.162.780', 'D12.776.157.530.450.250.880', 'D12.776.157.530.813.750', 'D12.776.543.58... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
An Intelligent Model for Blood Vessel Segmentation in Diagnosing DR Using CNN. | Diabetic retinopathy (DR) is an eye disease, which affects the people who are all having the diabetes for more than 10 years. The ophthalmologist identifies when the dilated eye exam causes severe in any one of the following deviations in the retina: changes in blood vessels, leaking blood vessels, newly grown blood ve... | ['Algorithms', 'Diabetic Retinopathy', 'Fundus Oculi', 'Humans', 'India', 'Neural Networks, Computer'] | 30,109,508 | [['G17.035', 'L01.224.050'], ['C11.768.257', 'C14.907.320.382', 'C19.246.099.500.382'], ['A09.371.729.313'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.245.393'], ['G17.485', 'L01.224.050.375.605']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Geographicals [Z]'] | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 |
Fenfluramine potentiates canine pulmonary vasoreactivity to endothelin-1. | The appetite suppressant fenfluramine, a serotonin uptake inhibitor, has been implicated in the development of primary pulmonary hypertension (PPH). The effect of fenfluramine on the pressor response to endothelin-1 (ET-1) in the canine pulmonary circulation was determined using the isolated perfused dog lung. Pulmonar... | ['Animals', 'Appetite Depressants', 'Capillary Resistance', 'Dogs', 'Endothelin-1', 'Female', 'Fenfluramine', 'Hypertension, Pulmonary', 'Male', 'Pulmonary Artery', 'Serotonin', 'Serotonin Uptake Inhibitors', 'Vasoconstriction'] | 9,918,753 | [['B01.050'], ['D27.505.954.203.155'], ['G09.330.380.921.327'], ['B01.050.150.900.649.313.750.250.216.200'], ['D12.644.276.400.225', 'D12.776.467.400.225', 'D23.529.400.225'], ['D02.092.471.683.467'], ['C08.381.423', 'C14.907.489.556'], ['A07.015.114.715'], ['D02.092.211.215.801.852', 'D03.633.100.473.914.814', 'D23.46... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Regioselective and stereospecific cleavage of a terminal oxirane system: a novel synthetic approach to lipid mediator congeners--1,2(2,3)-diacyl-3(1)-halo-sn-glycerols. | Glycidyl esters upon treatment with a mixture of carboxylic acid anhydride (CAA) and trimethylsilyl halide (TMSX) in the presence of tetra-n-butylammonium halide (Bu(4)NX, X=Cl, Br or I) undergo stereospecific and regioselective opening of the oxirane ring to afford mixed-(or mono)-acid 1,2(2,3)-diacyl-3(1)-halo-sn-gly... | ['Diglycerides', 'Ethylene Oxide', 'Molecular Structure', 'Stereoisomerism'] | 16,677,811 | [['D10.351.303'], ['D02.355.291.411.417'], ['G02.111.570', 'G02.466'], ['G02.607.445.682']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Membrane energization in relation with nitrogen fixation in Azotobacter vinelandii and Rhizobium leguminosarum bacteroids. | Nitrogen fixation in A. vinelandii and R. leguminosarum bacteroides shows identical characteristics with respect to the dependence on membrane energization, the sensitivity to uncouplers, the ATP/ADP-ratio, and the dependences on flavodoxinhydroquinone as electrondonor. Although we have been successful in preparing ins... | ['Adenosine Diphosphate', 'Adenosine Triphosphate', 'Azotobacter', 'Carbonyl Cyanide m-Chlorophenyl Hydrazone', 'Cell Membrane', 'Electron Transport', 'Kinetics', 'Nitrogen Fixation', 'Nitrogenase', 'Oligomycins', 'Rhizobium', 'Species Specificity'] | 667,180 | [['D03.633.100.759.646.138.124', 'D13.695.667.138.124', 'D13.695.827.068.124'], ['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['B03.440.400.425.625.050', 'B03.660.250.580.022'], ['D02.442.288.200', 'D02.626.260'], ['A11.284.149'], ['G02.111.248', 'G03.295.531.403', 'G03.493.350'], ['G01... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SIRT1 exerts protective effects against paraquat-induced injury in mouse type II alveolar epithelial cells by deacetylating NRF2 in vitro. | Silent information regulator 2-related enzyme 1 (SIRT1), a protein deacetylase, is known to strongly protect cells against oxidative stress-induced injury. The nuclear factor E2-related factor 2 (NRF2)-antioxidant response element (ARE) antioxidant pathway plays important regulatory roles in the antioxidant therapy of ... | ['Acetylation', 'Alveolar Epithelial Cells', 'Animals', 'Cells, Cultured', 'Lung Injury', 'Mice', 'Mice, Inbred ICR', 'NF-E2-Related Factor 2', 'Oxidative Stress', 'Paraquat', 'Sirtuin 1', 'Up-Regulation'] | 26,935,021 | [['G02.111.012.052', 'G02.607.063.052', 'G03.040.052'], ['A04.411.715.100', 'A11.436.081'], ['B01.050'], ['A11.251'], ['C08.381.520', 'C26.891.554'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.510', 'B01.050.150.900.649.313.992.635.505.500.400.510'], ['D12.776.260.108.737', 'D12.776.930.127.... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Genetic association in vitiligo: ABO, MNSs, Rhesus, Kell and Duffy blood groups. | One hundred and seventy Sudanese patients suffering from vitiligo were investigated for the distribution of A1A2BO, MNSs, Rhesus (genotypes), Kell and Duffy blood groups. The same genetic markers were investigated in Sudanese controls, consisting of two series: a published population series and a random sample of healt... | ['ABO Blood-Group System', 'Blood Group Antigens', 'Duffy Blood-Group System', 'Female', 'Humans', 'Kell Blood-Group System', 'MNSs Blood-Group System', 'Male', 'Rh-Hr Blood-Group System', 'Sudan', 'Vitiligo'] | 6,772,363 | [['D23.050.301.290.031', 'D23.050.705.230.031'], ['D23.050.301.290', 'D23.050.705.230'], ['D23.050.301.290.301', 'D23.050.705.230.301'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D23.050.301.290.533', 'D23.050.705.230.533'], ['D23.050.301.290.606', 'D23.050.705.230.606'], ['D23.050.301.290.775', 'D23.050.705.2... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Geographicals [Z]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Comparison of MR perfusion imaging and microsphere measurements of regional cerebral blood flow in a rat model of middle cerebral artery occlusion. | The purpose of this investigation was to correlate magnetic resonance (MR) perfusion measurements with absolute regional cerebral blood flow (rCBF) in a rat model of focal ischemia. The MR perfusion measurements were made using dynamic first-pass bolus tracking of a susceptibility contrast agent, whereas rCBF was measu... | ['Animals', 'Cerebral Arteries', 'Cerebrovascular Circulation', 'Contrast Media', 'Ischemic Attack, Transient', 'Magnetic Resonance Imaging', 'Male', 'Microspheres', 'Radioisotopes', 'Radionuclide Imaging', 'Rats', 'Rats, Wistar'] | 9,065,908 | [['B01.050'], ['A07.015.114.228'], ['G09.330.100.159'], ['D27.505.259.500', 'D27.720.259'], ['C10.228.140.300.150.836', 'C14.907.253.092.836'], ['E01.370.350.825.500'], ['E07.565'], ['D01.496.749'], ['E01.370.350.710', 'E01.370.384.730'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.50... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Parasites found in the mouths of inhabitants of three villages of South Kalimantan (Borneo), Indonesia. | Infection rates of parasites in the oral cavity were compared for two study areas in South Kalimantan, Indonesia. Penguiran and Sungai Baru, two adjacent villages, were considered a single study area and were inhabited by 151 individuals ranging from 2 to 70 years. Tanah Intan, the second study area, had a population o... | ['Adolescent', 'Adult', 'Aged', 'Candidiasis', 'Child', 'Child, Preschool', 'Entamoebiasis', 'Gingiva', 'Humans', 'Indonesia', 'Middle Aged', 'Mouth', 'Parasitic Diseases', 'Periodontal Diseases', 'Socioeconomic Factors', 'Trichomonas Infections'] | 6,729,983 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['C01.150.703.160'], ['M01.060.406'], ['M01.060.406.448'], ['C01.610.752.049.407'], ['A14.549.167.646.480'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.145.380', 'Z01.639.580'], ['M01.060.116.630'], ['A01.456.505.631', 'A03.556.500', 'A14.549'], ['... | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Learning curve for endoscopic submucosal dissection of gastric submucosal tumors: is it more difficult than it may seem? | BACKGROUND: Endoscopic submucosal dissection (ESD), as a minimally invasive technique, is gaining wide acceptance for treating epithelial neoplasms. More recently, some pioneers have developed ESD for the treatment of submucosal tumors (SMTs), but characterization of the learning curve is lacking. In this study we aime... | ['Adolescent', 'Adult', 'Aged', 'Choristoma', 'Clinical Competence', 'Dissection', 'Female', 'Gastric Mucosa', 'Gastrointestinal Stromal Tumors', 'Gastroscopy', 'Humans', 'Learning Curve', 'Leiomyoma', 'Middle Aged', 'Operative Time', 'Pancreas', 'Retrospective Studies', 'Stomach Diseases', 'Stomach Neoplasms', 'Tumor ... | 24,927,224 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['C23.300.250'], ['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['E01.370.225.998.221', 'E04.221', 'E05.200.998.221'], ['A03.556.875.875.440', 'A10.615.550.291'], ['C04.557.450.565.370', 'C06.301.371.308', 'C06.405.249.308'], ['E01.370.372.250.250.325', 'E01.3... | ['Named Groups [M]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Factors influencing palatoplasty and pharyngeal flap surgery. | An experience of 154 patients undergoing palatoplasty or pharyngeal flap surgery at the University of California, Davis, Medical Center (Sacramento) was retrospectively analyzed. There were 114 palatoplasties, 37 pharyngeal flaps, and three combined palatoplasty and pharyngeal flap procedures performed. Factors that co... | ['Airway Obstruction', 'Anti-Bacterial Agents', 'Body Temperature', 'California', 'Cephalosporins', 'Child, Preschool', 'Dexamethasone', 'Fluid Therapy', 'Humans', 'Incidence', 'Infant', 'Intraoperative Care', 'Length of Stay', 'Palate', 'Penicillins', 'Pharynx', 'Premedication', 'Retrospective Studies', 'Surgical Flap... | 2,021,474 | [['C08.618.846.185'], ['D27.505.954.122.085'], ['E01.370.600.875.374', 'G07.110'], ['Z01.107.567.875.580.200', 'Z01.107.567.875.760.200'], ['D02.065.589.099.249', 'D02.886.665.074', 'D03.633.100.300.249'], ['M01.060.406.448'], ['D04.210.500.745.432.769.344', 'D04.210.500.908.238'], ['E02.319.360'], ['B01.050.150.900.64... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Named Groups [M]', 'Organisms [B]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
[Multiparameter analysis using flow cytometry as additional tool for bladder cancer diagnosis]. | In order to find additional ways to classify bladder cancer, multiparameter analysis with antibodies against urothelial associated-glycoproteins (UAGAb: Uro1, -5, -9, -10; Signet) and cytokeratins (CKAb: KL1, Immunotech) were used in parallel with DNA staining. Single cell suspensions of 21 bladder cancer specimens (4p... | ['Antigens, Neoplasm', 'Carcinoma, Transitional Cell', 'DNA', 'DNA, Neoplasm', 'Epithelial Cells', 'Epithelium', 'Flow Cytometry', 'Humans', 'Immunohistochemistry', 'Neoplasm Staging', 'Ploidies', 'Urinary Bladder Neoplasms'] | 7,511,281 | [['D23.050.285'], ['C04.557.470.200.430'], ['D13.444.308'], ['D13.444.308.425'], ['A11.436'], ['A10.272'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.200.500.386.350', 'E05.242.363.342', 'E05.242.386.350'], ['B01.050.150.900.649.313.988.400.112.400.... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
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