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Proinsulin levels in patients with pancreatic diabetes are associated with functional changes in insulin secretion rather than pancreatic beta-cell area. | INTRODUCTION: Hyperproinsulinaemia has been reported in patients with type 2 diabetes. It is unclear whether this is due to an intrinsic defect in â-cell function or secondary to the increased demand on the â-cells. We investigated whether hyperproinsulinaemia is also present in patients with secondary diabetes, and wh... | ['Blood Glucose', 'Diabetes Mellitus', 'Female', 'Humans', 'Insulin', 'Insulin Resistance', 'Insulin Secretion', 'Insulin-Secreting Cells', 'Male', 'Pancreatic Diseases', 'Proinsulin'] | 20,679,359 | [['D09.947.875.359.448.500'], ['C18.452.394.750', 'C19.246'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D06.472.699.587.200.500.625', 'D12.644.548.586.200.500.625'], ['C18.452.394.968.500', 'G07.690.773.984.617'], ['G03.442', 'G07.475'], ['A03.734.414.131', 'A06.300.414.087', 'A06.390.131', 'A11.382.625.092', ... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Children with smoking parents have a higher airway resistance measured by the interruption technique. | Children exposed to environmental tobacco smoke, during or after pregnancy, are known to have decreased lung function. So far this has been measured using spirometry in schoolchildren and invasive techniques in newborns. The interruption technique (Rint) is a noninvasive technique to measure airway resistance in presch... | ['Airway Resistance', 'Child', 'Child, Preschool', 'Female', 'Humans', 'Male', 'Parent-Child Relations', 'Reference Values', 'Smoking', 'Tobacco Smoke Pollution'] | 15,470,684 | [['E01.370.386.700.050', 'G09.772.060'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.263.370.290'], ['E05.978.810'], ['F01.145.805'], ['D20.633.937.680', 'N06.850.460.100.555']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Named Groups [M]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
PARTIAL ANOMALOUS PULMONARY VENOUS CONNECTION WITH INTACT ATRIAL SEPTUM: A CASE REPORT. | Partial anomalous pulmonary venous connection (PAPVC) is a type of left to right shunt, when one or more lung veins drain to right atrium directly or indirectly via systemic veins. PAPVC is a rare condition, discovered by 0.4 to 0.7% of cases in autopsy series. It is often associated with atrial septal defect, but can ... | ['Adult', 'Anticoagulants', 'Atrial Septum', 'Brachiocephalic Veins', 'Female', 'Humans', 'Multidetector Computed Tomography', 'Pulmonary Artery', 'Pulmonary Veins', 'Thrombosis', 'Vascular Malformations'] | 26,719,548 | [['M01.060.116'], ['D27.505.954.502.119'], ['A07.541.459.249'], ['A07.015.908.130'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.350.810.800.500', 'E01.370.350.600.350.700.810.800.500', 'E01.370.350.700.700.810.800.500', 'E01.370.350.700.810.810.800.249', 'E01.370.350.825.810.810.800.249'], ['A07.015... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Understanding the physiological roles of polyhydroxybutyrate (PHB) in Rhodospirillum rubrum S1 under aerobic chemoheterotrophic conditions. | Polyhydroxybutyrate (PHB) is an important biopolymer accumulated by bacteria and associated with cell survival and stress response. Here, we make two surprising findings in the PHB-accumulating species Rhodospirillum rubrum S1. We first show that the presence of PHB promotes the increased assimilation of acetate prefer... | ['Acetates', 'Aerobiosis', 'Carbon Isotopes', 'Hydroxybutyrates', 'Isotope Labeling', 'Metabolic Flux Analysis', 'Polyesters', 'Rhodospirillum rubrum'] | 27,480,532 | [['D02.241.081.018', 'D10.251.400.045'], ['G02.111.017', 'G03.049'], ['D01.268.150.075', 'D01.496.123'], ['D02.241.081.114.937', 'D02.241.511.429', 'D10.251.400.143.781'], ['E05.522'], ['E01.370.225.500.810', 'E05.200.500.810', 'E05.242.654'], ['D05.750.728', 'D25.720.728', 'J01.637.051.720.728'], ['B03.440.400.425.708... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Vascular access cannulation in hemodialysis patients - a survey of current practice and its relation to dialysis dose. | PURPOSE: The appropriate use of vascular access is of fundamental importance in the treatment of hemodialysis (HD) patients. This survey entailed collecting data on current practice of vascular access cannulation to assess its relation to dialysis dose.METHODS: This international, multicenter, observational, cross-sect... | ['Arteriovenous Shunt, Surgical', 'Blood Vessel Prosthesis Implantation', 'Cross-Sectional Studies', 'Equipment Design', 'Europe', 'Health Care Surveys', 'Humans', 'Logistic Models', 'Needles', 'Odds Ratio', 'Punctures', 'Quality Improvement', 'Quality Indicators, Health Care', 'Renal Dialysis', 'South Africa', 'Survey... | 21,688,239 | [['E04.035.087', 'E04.100.814.868.249'], ['E04.100.814.868.500', 'E04.650.200'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['E05.320'], ['Z01.542'], ['E05.318.308.980.344', 'N03.349.380.210', 'N05.425.210', 'N05.715.360.300.800.344', 'N06.850.520.308.980.344'], ['B01.050.150.900.649... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
Glial cell line-derived neurotrophic factor (GDNF) as a novel candidate gene of anxiety. | Glial cell line-derived neurotrophic factor (GDNF) is a neurotrophic factor for dopaminergic neurons with promising therapeutic potential in Parkinson's disease. A few association analyses between GDNF gene polymorphisms and psychiatric disorders such as schizophrenia, attention deficit hyperactivity disorder and drug ... | ['Adult', 'Alleles', 'Anxiety', 'Depression', 'European Continental Ancestry Group', 'Female', 'Genetic Predisposition to Disease', 'Glial Cell Line-Derived Neurotrophic Factor', 'Haplotypes', 'Humans', 'Male', 'Polymorphism, Single Nucleotide', 'Self Report', 'Sex Factors', 'Young Adult'] | 24,324,616 | [['M01.060.116'], ['G05.360.340.024.340.030'], ['F01.470.132'], ['F01.145.126.350'], ['M01.686.508.400'], ['C23.550.291.687.500', 'G05.380.355'], ['D12.644.276.860.381.500', 'D12.776.467.860.381.500', 'D12.776.631.600.381.500', 'D23.529.850.381.500'], ['G05.380.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[The dependence of the corticoliberin-like activity of the hypothalamus on parathormone]. | Corticoliberine-like activity of the paraventricular nucleus area and median eminence, concentration of plasma 11-oxycorticosteroids and total blood calcium were studied after parathyroidectomy, parathyroid hormone of calcium gluconate injections in rats. Hypercalcemia and especially parathyroid hormone stimulated the ... | ['11-Hydroxycorticosteroids', 'Animals', 'Calcium', 'Calcium Gluconate', 'Corticotropin-Releasing Hormone', 'Hypothalamus', 'Male', 'Parathyroid Glands', 'Parathyroid Hormone', 'Physical Exertion', 'Rats'] | 2,163,921 | [['D06.472.040.585.353'], ['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D02.241.081.844.322.200', 'D02.241.511.902.322.200', 'D09.811.308.200'], ['D06.472.699.327.740.140', 'D12.644.400.400.740.140', 'D12.644.548.365.740.140', 'D12.776.631.650.405.740.140'], ['A08.186.211.180.497', 'A08.186.211.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Refined carbohydrate intake in relation to non-verbal intelligence among Tehrani schoolchildren. | OBJECTIVE: Nutrition has long been considered one of the most important environmental factors affecting human intelligence. Although carbohydrates are the most widely studied nutrient for their possible effects on cognition, limited data are available linking usual refined carbohydrate intake and intelligence. The pres... | ['Child', 'Child Development', 'Child Nutritional Physiological Phenomena', 'Cross-Sectional Studies', 'Diet', 'Dietary Carbohydrates', 'Female', 'Food Handling', 'Humans', 'Intelligence', 'Intelligence Tests', 'Iran', 'Male', 'Socioeconomic Factors'] | 22,153,053 | [['M01.060.406'], ['F01.525.200', 'G07.345.374.750'], ['G07.203.650.220'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['G07.203.650.240'], ['D09.301', 'G07.203.300.362', 'J02.500.362'], ['J01.576.423.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.752.543'], ['F04.711.1... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Geographicals [Z]', 'Anthropology, Education, Sociolog... | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
The pendulum test for evaluating spasticity of the elbow joint. | OBJECTIVE: To develop a modification of the pendulum test to allow evaluation of elbow spasticity.DESIGN: The main difficulties of directly applying the conventional pendulum test to the elbow were the small inertia of the forearm and the uncomfortable posture. We designed an experimental apparatus similar to a clock p... | ['Adult', 'Aged', 'Algorithms', 'Biomechanical Phenomena', 'Elbow Joint', 'Electromyography', 'Humans', 'Middle Aged', 'Muscle Spasticity', 'Stroke Rehabilitation'] | 12,589,623 | [['M01.060.116'], ['M01.060.116.100'], ['G17.035', 'L01.224.050'], ['G01.154.090', 'G01.374.089'], ['A02.835.583.290'], ['E01.370.405.255', 'E01.370.530.255'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C05.651.512', 'C10.597.613.550.550', 'C23.888.592.608.550.550'], ['E02.760.169.063.500.4... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 |
Ephaptic recurrent response in man. | The antidromic impulse associated to the ephaptic response can produce a recurrent wave (Fe). Its latency, which is longer than that of the F wave, will augment if the site of stimulation is remote from the muscle. It is therefore a direct-indirect response. The 'Fe' wave is similar to the 'S' response described by Tho... | ['Aged', 'Electric Stimulation', 'Evoked Potentials', 'Humans', 'Middle Aged', 'Motor Neurons', 'Muscles', 'Neural Conduction'] | 488,144 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bisected, complex N-glycans and galectins in mouse mammary tumor progression and human breast cancer. | Bisected, complex N-glycans on glycoproteins are generated by the glycosyltransferase MGAT3 and cause reduced cell surface binding of galectins. Previously, we showed that MGAT3 reduces growth factor signaling and retards mammary tumor progression driven by the Polyoma middle T antigen (PyMT) expressed in mammary epith... | ['Animals', 'Antigens, Polyomavirus Transforming', 'Breast Neoplasms', 'Disease Models, Animal', 'Disease Progression', 'Female', 'Galectins', 'Humans', 'Mammary Neoplasms, Experimental', 'Mammary Tumor Virus, Mouse', 'Mice', 'Mice, Inbred Strains', 'N-Acetylglucosaminyltransferases', 'Polysaccharides'] | 24,037,315 | [['B01.050'], ['D12.776.624.664.520.090', 'D12.776.964.700.090', 'D23.050.285.062.090', 'D23.050.327.062.090'], ['C04.588.180', 'C17.800.090.500'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['C23.550.291.656'], ['D12.776.503.307'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.531.500', 'C04.619.590',... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Biosynthesis of enniatin by washed cells of Fusarium sambucinum]. | Biosynthesis of the depsipeptide membrane ionophore--enniatin B by the washed mycelium Fusarium sambucinum Fuck 52 377 was studied. Metabolic precursors of enniatin B, alpha-ketovaleric acid, 14C-L-valine, and 14CH3-methionine, were added to the system after starvation. The amino acid content in the metabolic pool incr... | ['Anti-Bacterial Agents', 'Carbon Radioisotopes', 'Fusarium', 'Kinetics', 'Methionine', 'Valerates', 'Valine'] | 583,180 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Urethral strictures in boys. | While common in adult males, urethral strictures are comparatively rare in boys. We report our experience with this condition in 19 boys. Ten of the strictures were iatrogenic, seven traumatic, and three inflammatory in origin. Dilation is reportedly unsatisfactory for the management of most urethral strictures in chil... | ['Child', 'Child, Preschool', 'Dilatation', 'Humans', 'Male', 'Urethra', 'Urethral Stricture'] | 3,603,909 | [['M01.060.406'], ['M01.060.406.448'], ['E05.284'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A05.360.444.492.726', 'A05.810.876'], ['C12.777.767.700.700', 'C13.351.968.767.700.700']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Patterns of developmental expression of the RNA editing enzyme rADAR2. | To date, two structurally related RNA-editing enzymes with adenosine deaminase activity have been identified in mammalian tissue: ADAR1 and ADAR2 [Bass B. I. et al. (1997) RNA 3, 947-949]. In rodents, ADAR2 undergoes alternative RNA splicing, giving rise to two splice variants that differ by the presence or absence of ... | ['Adenosine Deaminase', 'Aging', 'Animals', 'Animals, Newborn', 'Embryonic and Fetal Development', 'Fetus', 'Hippocampus', 'RNA Editing', 'RNA, Double-Stranded', 'RNA-Binding Proteins', 'Rats', 'Rats, Sprague-Dawley'] | 10,670,454 | [['D08.811.277.151.486.075'], ['G07.345.124'], ['B01.050'], ['B01.050.050.282'], ['G07.345.500.325', 'G08.686.784.170'], ['A16.378'], ['A08.186.211.180.405', 'A08.186.211.200.885.287.500.345'], ['G02.111.760.250', 'G03.839.250', 'G05.308.700.250'], ['D13.444.735.490', 'G02.111.570.820.486.775', 'G05.360.580.775'], ['D1... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Experiences of psychosocial adjustment within 18 months of amputation: an interpretative phenomenological analysis. | PURPOSE: To explore participants' experiences of psychosocial adjustment within 18-months following amputation in a manner that can inform further research and clinical practice.METHOD: Transcript data from eight semi-structured interviews were analysed using Interpretative Phenomenological Analysis.RESULTS: Three supe... | ['Adaptation, Psychological', 'Adult', 'Amputation', 'Decision Making', 'Disabled Persons', 'Female', 'Humans', 'Interviews as Topic', 'Male', 'Pain', 'Qualitative Research', 'Social Identification'] | 20,302,441 | [['F01.058'], ['M01.060.116'], ['E04.555.080'], ['F02.463.785.373'], ['M01.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.420', 'L01.399.250.520', 'N05.715.360.300.400', 'N06.850.520.308.420'], ['C23.888.592.612', 'F02.830.816.444', 'G11.561.790.444'], ['H01.770.644.241.850'], ['F01.145.813.708']... | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Information Science [L]', 'Health Care [N]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 |
Stimulus duration and waves of auditory brainstem response. | This study was conducted to investigate the effects of stimulus duration on auditory brainstem response (ABR) waveform. Stimuli were 3-kHz tone bursts with 1 ms rise/fall times and durations of 5, 10, 20 and 30 ms. They were delivered at interstimuli intervals ranging from 80 to 140 ms. Latency and amplitude increases ... | ['Acoustic Stimulation', 'Animals', 'Brain Stem', 'Evoked Potentials, Auditory', 'Humans', 'Rats', 'Reaction Time', 'Time Factors'] | 3,753,306 | [['E02.037', 'E02.190.888.030', 'E05.723.136'], ['B01.050'], ['A08.186.211.132'], ['G07.265.216.500.370', 'G07.888.250', 'G11.561.200.500.370'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649.313.992.635.505.700'], ['E05.796.817', 'F02.830.650', 'F04.669.817', 'G11.561.677'], ['G01.910.857']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Liability in the context of misdiagnosis of melanoma in Australia. | Malignant melanoma is a serious and relatively common condition, the diagnosis of which may be difficult. In a recent Supreme Court of New South Wales case, misdiagnosis of melanoma occurred, but there was failure to establish causation of the patient's poor prognosis. Aggressive melanomas may grow quickly, fail to con... | ['Australia', 'Diagnostic Errors', 'Humans', 'Liability, Legal', 'Melanoma', 'Skin Neoplasms'] | 24,484,118 | [['Z01.639.100', 'Z01.678.100.373'], ['E01.354', 'N02.421.450.280'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I01.880.604.583.490', 'N03.706.535.547'], ['C04.557.465.625.650.510', 'C04.557.580.625.650.510', 'C04.557.665.510'], ['C04.588.805', 'C17.800.882']] | ['Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Adenosine and selective A(2A) receptor agonists reduce ischemia/reperfusion injury of rat liver mainly by inhibiting leukocyte activation. | To examine whether adenosine reduces ischemia/reperfusion (I/R)-induced liver injury by inhibiting leukocyte activation via A(2) receptor (A(2)R) stimulation, we investigated the effects of adenosine and selective A(2A) receptor (A(2A)R) agonists (YT-146 and CGS21680C) on I/R-induced liver injury in rats. Adenosine, YT... | ['Adenosine', 'Alkynes', 'Animals', 'Calcium', 'Cells, Cultured', 'Chemokine CXCL1', 'Chemokines, CXC', 'Chemotactic Factors', 'Growth Substances', 'Humans', 'Intercellular Signaling Peptides and Proteins', 'Ischemia', 'Leukocyte Elastase', 'Lipopolysaccharides', 'Liver', 'Male', 'Monocytes', 'Neutrophil Activation', '... | 10,945,856 | [['D03.633.100.759.590.138', 'D13.570.583.138', 'D13.570.800.096'], ['D02.455.326.397'], ['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['A11.251'], ['D12.644.276.374.200.120.050', 'D12.776.467.374.200.120.050', 'D12.776.624.664.700.049', 'D23.125.300.120.050', 'D23.469.200.120.050', 'D23.529.374.2... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Duration of recurrent ileitis after ileocolonic resection correlates with presurgical extent of Crohn's disease. | Crohn's disease of the terminal ileum recurs in a predictable sequence proximal to the ileocolonic anastomosis after surgical resection. To confirm the suspicion that the duration of recurrent ileitis correlates with the extent of presurgical disease, this study investigated 23 consecutive patients with recurrent Crohn... | ['Adolescent', 'Adult', 'Child', 'Crohn Disease', 'Female', 'Humans', 'Ileitis', 'Male', 'Postoperative Period', 'Prognosis', 'Recurrence'] | 7,797,122 | [['M01.060.057'], ['M01.060.116'], ['M01.060.406'], ['C06.405.205.731.500', 'C06.405.469.432.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C06.405.205.462.624', 'C06.405.469.326.875', 'C06.405.469.420.520'], ['E04.614.750', 'N02.421.585.753.750'], ['E01.789'], ['C23.550.291.937']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Biodiversity of killer activity in yeasts isolated from the Brazilian rain forest. | The occurrence of killer activity against a panel composed of 22 industrially and (or) medically important yeasts was investigated in 438 yeast and yeast-like cultures belonging to 96 species, isolated from different environments of the Brazilian rain forest. Altogether, 26% of ascomycetes, 56% of basidiomycetes, and 4... | ['Ascomycota', 'Basidiomycota', 'Brazil', 'Drug Evaluation, Preclinical', 'Ecosystem', 'Microbial Sensitivity Tests', 'Mycotoxins', 'Plasmids', 'Trees', 'Yeasts'] | 10,932,353 | [['B01.300.107'], ['B01.300.179'], ['Z01.107.757.176'], ['E05.290.750', 'E05.337.550'], ['G16.500.275.157', 'N06.230.124'], ['E01.370.225.875.595', 'E05.200.875.595', 'E05.337.550.400'], ['D23.946.587'], ['G05.360.600'], ['B01.650.915'], ['B01.300.930']] | ['Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Lymphatic invasion predicts sentinel lymph node metastasis and adverse outcome in primary cutaneous melanoma. | BACKGROUND: Sentinel lymph node (SLN) metastasis is a powerful predictor of survival in primary cutaneous melanoma. Lymphatic invasion (LI) may correlate with increased risk of SLN metastasis. Intralymphatic metastases, often difficult to detect on hematoxylin and eosin (H&E) stained sections, are readily identified wi... | ['Adult', 'Aged', 'Biomarkers, Tumor', 'Disease-Free Survival', 'Female', 'Humans', 'Immunohistochemistry', 'Kaplan-Meier Estimate', 'Lymphatic Metastasis', 'Male', 'Melanoma', 'Middle Aged', 'Proportional Hazards Models', 'Sentinel Lymph Node', 'Skin Neoplasms'] | 28,555,886 | [['M01.060.116'], ['M01.060.116.100'], ['D23.101.140'], ['E01.789.800.190', 'E05.318.740.998.300', 'N04.761.559.590.800.190', 'N05.715.360.575.575.800.190', 'N05.715.360.750.795.300', 'N06.850.520.830.998.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Neuronal organization of the central respiratory mechanisms in the brain stem of the cat. | In order to obtain basic evidence on the neuronal organization and localization of the central respiratory mechanism in the brain stem of the cat, the following experiments were undertaken: reexamination of the physiological meaning of apneusis and the gasp; differences in stability of spontaneous burst activity of res... | ['Animals', 'Brain Stem', 'Cats', 'Electroencephalography', 'Electrophysiology', 'Hyperventilation', 'Neurons', 'Phrenic Nerve', 'Respiration', 'Respiration, Artificial', 'Respiratory Center', 'Reticular Formation', 'Vagus Nerve'] | 4,698,502 | [['B01.050'], ['A08.186.211.132'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['E01.370.376.300', 'E01.370.405.245'], ['H01.158.344.528', 'H01.158.782.236'], ['C08.618.501', 'C23.888.852.591'], ['A08.675', 'A11.671'], ['A08.800.800.720.150.700'], ['G09.772.705'], ['E02.041.625', 'E02.365.647.729', 'E02.880.820'],... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
First cases of spotted fever group rickettsiosis in Thailand. | The first three cases of spotted fever group rickettsiosis from Thailand are reported. The patients presented with fever, headache, lymphadenopathy, and petechial maculopapular rash. One patient also had an eschar and overt evidence of confusion. An indirect fluorescent antibody test, an indirect immunoperoxidase test,... | ['Adult', 'Agglutination Tests', 'Antibodies, Bacterial', 'Child', 'Enzyme-Linked Immunosorbent Assay', 'Fluorescent Antibody Technique', 'Humans', 'Immunoenzyme Techniques', 'Male', 'Middle Aged', 'Rickettsia', 'Rickettsia Infections', 'Thailand'] | 8,024,059 | [['M01.060.116'], ['E01.370.225.812.735.050', 'E05.200.812.735.050', 'E05.478.594.760.050'], ['D12.776.124.486.485.114.107', 'D12.776.124.790.651.114.125', 'D12.776.377.715.548.114.125'], ['M01.060.406'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360']... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
The effects of thyroid hormones on the skin of beagle dogs. | The effects of hypothyroidism on canine skin were determined by comparing morphologic, morphometric, and hair cycle differences in skin biopsy samples from 3 groups of age- and gender-matched Beagle dogs: (1) euthyroid dogs; (2) dogs made hypothyroid by administration of 131I; and (3) dogs made hypothyroid and maintain... | ['Alopecia', 'Animals', 'Dog Diseases', 'Dogs', 'Hair Follicle', 'Hypothyroidism', 'Male', 'Thyroxine'] | 11,817,058 | [['C17.800.329.937.122', 'C23.300.035'], ['B01.050'], ['C22.268'], ['B01.050.150.900.649.313.750.250.216.200'], ['A10.272.497.500', 'A17.360.710', 'A17.815.250.500'], ['C19.874.482'], ['D06.472.931.812', 'D12.125.072.050.767']] | ['Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cloning and characterization of a galactitol 2-dehydrogenase from Rhizobium legumenosarum and its application in D-tagatose production. | Galactitol 2-dehydrogenase (GDH) belongs to the protein subfamily of short-chain dehydrogenases/reductases and can be used to produce optically pure building blocks and for the bioconversion of bioactive compounds. An NAD(+)-dependent GDH from Rhizobium leguminosarum bv. viciae 3841 (RlGDH) was cloned and overexpressed... | ['Amino Acid Motifs', 'Amino Acid Sequence', 'Bacterial Proteins', 'Catalysis', 'Chromatography, Affinity', 'Chromatography, Gel', 'Cloning, Molecular', 'Electrophoresis, Polyacrylamide Gel', 'Escherichia coli', 'Galactitol', 'Genes, Bacterial', 'Hydrogen-Ion Concentration', 'Models, Molecular', 'Molecular Sequence Dat... | 24,731,824 | [['G02.111.570.820.709.275.500', 'G02.111.570.820.709.600.500'], ['G02.111.570.060', 'L01.453.245.667.060'], ['D12.776.097'], ['G02.130'], ['E05.196.181.400.170'], ['E05.196.181.400.250'], ['E05.393.220'], ['E05.196.401.402', 'E05.301.300.319'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D02.033.800.400'... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
IDH1 and IDH2 have critical roles in 2-hydroxyglutarate production in D-2-hydroxyglutarate dehydrogenase depleted cells. | D-2-hydroxyglutaric aciduria (D-2HGA) is a hereditary metabolic disorder characterized by the elevated levels of D-2-hydroxyglutaric acid (D-2HG) in urine, plasma and cerebrospinal fluid. About half of the patients have autosomal recessive mutations in D-2-hydroxyglutarate dehydrogenase (D2HGDH) gene. To analyze the or... | ['Alcohol Oxidoreductases', 'Cell Line, Tumor', 'Gene Knockdown Techniques', 'Glutarates', 'Humans', 'Isocitrate Dehydrogenase', 'RNA, Small Interfering'] | 22,683,334 | [['D08.811.682.047'], ['A11.251.210.190', 'A11.251.860.180'], ['E05.393.335.500'], ['D02.241.081.337.351'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.682.047.820.475'], ['D13.150.650.700', 'D13.444.735.150.700', 'D13.444.735.790.552.875']] | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Cartilage joint transplantation (author's transl)]. | The present day knowledge and the practical use of cartilage joint transplantation in the knee joint are reviewed. Apart from the refixation of cartilage-bone and pure cartilage fragments, autologous transplantation has not fulfilled the expectation anticipated from animal experiments. Apart from the question of the so... | ['Adult', 'Cartilage, Articular', 'Child', 'Child, Preschool', 'Humans', 'Knee Joint', 'Male', 'Middle Aged', 'Temporomandibular Joint', 'Transplantation, Autologous', 'Transplantation, Homologous'] | 919,841 | [['M01.060.116'], ['A02.165.407.150', 'A02.835.583.192'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.583.475'], ['M01.060.116.630'], ['A02.835.583.861', 'A14.907'], ['E04.936.664'], ['E04.936.864']] | ['Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Improvement of left ventricular function in alcoholic cardiomyopathy documented by serial gated cardiac pool scanning. | Serial gated cardiac blood pool scans showed a gradual return to normal left ventricular function over ten months in a 44-year-old patient who presented initially with severe alcoholic congestive cardiomyopathy. The clinical signs of left ventricular failure abated considerably before myocardial function improved objec... | ['Adult', 'Cardiomyopathy, Alcoholic', 'Coronary Vessels', 'Heart Ventricles', 'Humans', 'Male', 'Radiography', 'Radionuclide Imaging', 'Remission, Spontaneous'] | 292,382 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
HFR1 encodes an atypical bHLH protein that acts in phytochrome A signal transduction. | Phytochromes are informational photoreceptors through which plants adapt their growth and development to prevailing light conditions. These adaptations are effected primarily through phytochrome regulation of gene expression by mechanisms that remain unclear. We describe a new mutant, hfr1 (long hypocotyl in far-red), ... | ['Amino Acid Sequence', 'Arabidopsis', 'Arabidopsis Proteins', 'Basic Helix-Loop-Helix Transcription Factors', 'Chromosome Mapping', 'Cloning, Molecular', 'DNA-Binding Proteins', 'Gene Expression Regulation, Plant', 'Genetic Complementation Test', 'Hypocotyl', 'Light', 'Molecular Sequence Data', 'Nuclear Proteins', 'Ph... | 10,995,393 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.650.940.800.575.912.250.157.100'], ['D12.776.765.149'], ['D12.776.260.103', 'D12.776.930.125'], ['E05.393.183'], ['E05.393.220'], ['D12.776.260'], ['G05.308.375'], ['E05.393.281.526'], ['A18.024.875.750', 'A18.024.937.249', 'A18.550.500'], ['G01.358.500.505.650', 'G01.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Adaptive Resonance Theory in the time scales calculus. | Engineering applications of algorithms based on Adaptive Resonance Theory have proven to be fast, reliable, and scalable solutions to modern industrial machine learning problems. A key emerging area of research is in the combination of different kinds of inputs within a single learning architecture along with ensuring ... | ['Mathematical Concepts', 'Unsupervised Machine Learning'] | 31,500,932 | [['G17'], ['G17.035.250.500.750', 'L01.224.050.375.530.750']] | ['Phenomena and Processes [G]', 'Information Science [L]'] | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Full-dose gemcitabine with concurrent radiation therapy in patients with nonmetastatic pancreatic cancer: a multicenter phase II trial. | PURPOSE: Gemcitabine is effective in the treatment of pancreatic cancer and is a potent radiosensitizer. This study assessed safety and efficacy of full-dose gemcitabine administered before and during concurrent three-dimensional conformal radiation (3D-CRT) in patients with nonmetastatic pancreatic cancer.PATIENTS AND... | ['Adult', 'Aged', 'Aged, 80 and over', 'Antimetabolites, Antineoplastic', 'Biomarkers, Tumor', 'CA-19-9 Antigen', 'Chemotherapy, Adjuvant', 'Deoxycytidine', 'Female', 'Humans', 'Male', 'Middle Aged', 'Nausea', 'Neoplasm Staging', 'Neutropenia', 'Pancreatic Neoplasms', 'Radiotherapy, Adjuvant', 'Radiotherapy, Conformal'... | 18,281,668 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.519.186.144', 'D27.505.954.248.144', 'D27.888.569.042.030'], ['D23.101.140'], ['D23.050.285.050.119', 'D23.050.301.290.544.119', 'D23.050.550.325.119', 'D23.050.705.230.544.119', 'D23.101.140.075.119'], ['E02.186.170', 'E02.319.170'], ['D03.383.7... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Information Science [L]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
[Impact of COVID-19 during de-escalation in pediatric urology.] | Medical and surgical priorities have changed dramatically following the COVID-19 pandemic declaration. The rapid spread of the virus and the high number of cases has saturated the health system in our country and has forced many hospitals to redistribute resources to care for infected patients. This has led to asignifi... | ['Betacoronavirus', 'COVID-19', 'Child', 'Coronavirus Infections', 'Humans', 'Pandemics', 'Pneumonia, Viral', 'SARS-CoV-2', 'Urologic Surgical Procedures', 'Urology'] | 32,538,817 | [['B04.820.578.500.540.150.113'], ['C01.748.214', 'C01.748.610.763.500', 'C01.925.705.500', 'C01.925.782.600.550.200.163', 'C08.381.677.807.500', 'C08.730.214', 'C08.730.610.763.500'], ['M01.060.406'], ['C01.925.782.600.550.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N06.850.290.200.600'], ['C01.748.610.7... | ['Organisms [B]', 'Diseases [C]', 'Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Activation of MAPKs in proximal tubule cells from spontaneously hypertensive and control Wistar-Kyoto rats. | The aim of this study was to test the hypothesis that differences exist in the activity and/or expression of mitogen-activated protein kinases (MAPKs) between spontaneously hypertensive rats (SHR) and control Wistar-Kyoto rats (WKY) and that these differences may account for the enhanced activity of the Na(+)/H(+) exch... | ['Angiotensin II', 'Animals', 'Hypertension', 'Kidney Tubules', 'Mitogen-Activated Protein Kinases', 'Rats', 'Rats, Inbred SHR', 'Rats, Inbred WKY'] | 10,818,081 | [['D06.472.699.094.078', 'D12.644.400.070.078', 'D12.644.456.073.041', 'D12.644.548.058.078', 'D12.776.631.650.070.078', 'D23.469.050.050.050'], ['B01.050'], ['C14.907.489'], ['A05.810.453.736.560'], ['D08.811.913.696.620.682.700.567', 'D12.644.360.450', 'D12.776.476.450'], ['B01.050.150.900.649.313.992.635.505.700'], ... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Immunohistochemical localization of minor gangliosides in the rat central nervous system. | We previously described the differential distribution of major gangliosides (GM1, GD1a, GD1b, GT1b and GQ1b) in adult rat brain detected by specific antibodies (Kotani, M., Kawashima, I., Ozawa, I., Terashima, T. and Tai, T. Glycobiology, 3, 137-146, 1993). We report here the distribution of minor gangliosides in the a... | ['Animals', 'Antibodies, Monoclonal', 'Antibody Specificity', 'Carbohydrate Sequence', 'Central Nervous System', 'Cerebellar Cortex', 'Cerebral Cortex', 'Gangliosides', 'Hippocampus', 'Immunohistochemistry', 'Molecular Sequence Data', 'Rats', 'Spinal Cord'] | 7,734,848 | [['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['G12.100'], ['G02.111.570.160', 'L01.453.245.667.160'], ['A08.186'], ['A08.186.211.132.810.428.200.212'], ['A08.186.211.200.885.287.500'], ['D09.400.410.420.025.475', 'D10.390.470.025.475', 'D10.570.877.360.025... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
[Pararheumatic diseases in leukoses]. | Pararheumatic complaints may be the leading clinical symptom in the individual case also in leucoses and may lead to diagnostic errors. They are caused by leucotic infiltrates in juxta-articular bone segments, sporadically also by blast infiltrates of the synovial membrane, by secondary osteoporoses or osteoscleroses a... | ['Diagnosis, Differential', 'Humans', 'Leukemia', 'Osteoarthritis', 'Osteoporosis', 'Osteosclerosis', 'Rheumatic Diseases'] | 302,068 | [['E01.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.337'], ['C05.550.114.606', 'C05.799.613'], ['C05.116.198.579', 'C18.452.104.579'], ['C05.116.099.708.702'], ['C05.799', 'C17.300.775']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Oronasal partitioning of ventilation during exercise in humans. | The partitioning of oronasal breathing was studied in five normal subjects during progressive exercise. Subjects performed three to five identical runs, each consisting of four 1-min work periods at increments of 50 W. Nasal and oral airflow were measured simultaneously using a partitioned face mask both during and for... | ['Adult', 'Airway Resistance', 'Ergometry', 'Exercise', 'Humans', 'Male', 'Mouth Breathing', 'Nose', 'Respiratory Function Tests', 'Respiratory Mechanics'] | 1,938,727 | [['M01.060.116'], ['E01.370.386.700.050', 'G09.772.060'], ['E05.333'], ['G11.427.410.698.277', 'I03.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C08.618.659', 'C23.888.852.761'], ['A01.456.505.733', 'A04.531', 'A09.531'], ['E01.370.386.700'], ['G09.772.705.700']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Repeatability in the assessment of multi-segment foot kinematics. | A recently published systematic review on 3D multi-segment foot models has illustrated the lack of repeatability studies providing evidence for appropriate clinical decision making. The aim of the current study was to assess the repeatability of the recently published model developed by Leardini et al. [10]. Foot kinem... | ['Adult', 'Biomechanical Phenomena', 'Exercise Test', 'Female', 'Foot', 'Forefoot, Human', 'Gait', 'Humans', 'Imaging, Three-Dimensional', 'Male', 'Middle Aged', 'Photogrammetry', 'Radiography', 'Reference Values', 'Reproducibility of Results', 'Sampling Studies', 'Sensitivity and Specificity', 'Young Adult'] | 22,100,210 | [['M01.060.116'], ['G01.154.090', 'G01.374.089'], ['E01.370.370.380.250', 'E01.370.386.700.250', 'E05.333.250'], ['A01.378.610.250'], ['A01.378.610.250.300'], ['E01.370.600.250', 'G11.427.410.568.900.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.400', 'L01.224.308.410'], ['M01.060.116.630'], ['E... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Information Science [L]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Integrative structure modeling with the Integrative Modeling Platform. | Building models of a biological system that are consistent with the myriad data available is one of the key challenges in biology. Modeling the structure and dynamics of macromolecular assemblies, for example, can give insights into how biological systems work, evolved, might be controlled, and even designed. Integrati... | ['Computational Biology', 'Computer Simulation', 'Models, Molecular', 'Software'] | 28,960,548 | [['H01.158.273.180', 'L01.313.124'], ['L01.224.160'], ['E05.599.595'], ['L01.224.900']] | ['Disciplines and Occupations [H]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
[Neonatal meningitis. Study of 26 cases and a review of its sequelae after 5 years]. | Twenty-six cases of neonatal meningitis in term newborns are studied. Incidence, etiological features, treatment, clinical and biochemical evolution and mortality are analysed. Lief motif of this paper is the search for deficits in psychomotor growth in propositi of four and six years old, finding an important relation... | ['Developmental Disabilities', 'Follow-Up Studies', 'Humans', 'Infant, Newborn', 'Intelligence', 'Meningitis', 'Psychomotor Performance'] | 2,461,673 | [['F03.625.421'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['F01.752.543'], ['C10.228.614'], ['F02.808', 'G11.427.700', 'G11.561.660']] | ['Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Patient preferences for early discharge after laparoscopic cholecystectomy. | UNLABELLED: Patients may have concerns about their ability to manage postoperative symptoms at home after ambulatory surgery. We assessed patients' attitudes toward postoperative care at home or in the hospital after laparoscopic cholecystectomy. Thirty-eight patients undergoing elective laparoscopic cholecystectomy we... | ['Adult', 'Cholecystectomy, Laparoscopic', 'Female', 'Humans', 'Length of Stay', 'Male', 'Middle Aged', 'Patient Discharge', 'Patient Satisfaction', 'Postoperative Care'] | 10,357,330 | [['M01.060.116'], ['E04.210.120.172.140', 'E04.502.250.520.160'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.760.400.480', 'N02.421.585.400.480'], ['M01.060.116.630'], ['E02.760.169.125', 'E02.760.400.610', 'N02.421.585.169.125', 'N02.421.585.400.610', 'N04.590.233.727.210.125'], ['F01.100.150.750.625', 'F0... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Evaluation of a proposed molecular methodology for the serotyping of Avibacterium paragallinarum. | A multiplex (m)PCR and a PCR followed by restriction fragment length polymorphism (RFLP) analysis of Avibacterium paragallinarum have been proposed as alternatives to conventional serotyping by the Page scheme. We evaluated both methods, and also sequenced the PCR-RFLP target fragment to reexamine the capacity of molec... | ['Animals', 'Chickens', 'Haemophilus Infections', 'Haemophilus paragallinarum', 'Polymerase Chain Reaction', 'Polymorphism, Restriction Fragment Length', 'Poultry Diseases', 'Sensitivity and Specificity', 'Serotyping'] | 27,423,732 | [['B01.050'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['C01.150.252.400.700.433'], ['B03.440.450.600.450.665', 'B03.660.250.550.290.665'], ['E05.393.620.500'], ['G05.365.795.595'], ['C22.131.728'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700', 'N05.715.360.750.725', 'N... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Effect of lead acetate on the in vitro engulfment and killing capability of toad (Bufo arenarum) neutrophils. | Lead is an element of risk for the environment and human health and has harmful effects that may exceed those of other inorganic toxicants. The immune system is one of the targets of lead. Its immunomodulatory actions depend on the level of exposure, and it has been demonstrated that environmental amounts of the metal ... | ['Animals', 'Bufo arenarum', 'Candida tropicalis', 'Lead', 'Lead Poisoning', 'Leukocyte Count', 'Male', 'Neutrophils', 'Organometallic Compounds', 'Phagocytosis', 'Water Pollutants, Chemical'] | 14,659,456 | [['B01.050'], ['B01.050.150.900.090.180.210.080'], ['B01.300.107.795.095.800', 'B01.300.381.147.800', 'B01.300.930.176.800'], ['D01.268.556.435', 'D01.552.544.435'], ['C25.723.522.750'], ['E01.370.225.500.195.107.595', 'E01.370.225.625.107.595', 'E05.200.500.195.107.595', 'E05.200.625.107.595', 'E05.242.195.107.595', '... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Ethanol directly inhibits delta 5-3 beta-hydroxysteroid dehydrogenase-isomerase activity in rat testis interstitial cells. | Acute ethanol exposure has been demonstrated to inhibit testosterone synthesis both in vivo and in vitro; however, the precise step(s) affected is controversial. Using intact collagenase-dispersed interstitial cells or 10,000 xg supernatants of interstitial cell homogenates, studies were undertaken to determine whether... | ['3-Hydroxysteroid Dehydrogenases', 'Alcohol Oxidoreductases', 'Animals', 'Ethanol', 'Fomepizole', 'In Vitro Techniques', 'Leydig Cells', 'Male', 'NAD', 'Pyrazoles', 'Rats', 'Rats, Inbred Strains', 'Testis'] | 6,388,053 | [['D08.811.682.047.436.350'], ['D08.811.682.047'], ['B01.050'], ['D02.033.375'], ['D03.383.129.539.344'], ['E05.481'], ['A05.360.444.849.513', 'A06.300.312.782.513', 'A11.382.906', 'A11.436.513'], ['D03.633.100.759.646.138.694', 'D08.211.589', 'D13.695.667.138.694', 'D13.695.827.068.694'], ['D03.383.129.539'], ['B01.05... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Progranulin associates with hexosaminidase A and ameliorates GM2 ganglioside accumulation and lysosomal storage in Tay-Sachs disease. | Tay-Sachs disease (TSD) is a lethal lysosomal storage disease (LSD) caused by mutations in the HexA gene, which can lead to deficiency of â-hexosaminidase A (HexA) activity and consequent accumulation of its substrate, GM2 ganglioside. Recent reports that progranulin (PGRN) functions as a chaperone of lysosomal enzymes... | ['Animals', 'Brain', 'Disease Models, Animal', 'Fibroblasts', 'Gangliosides', 'HEK293 Cells', 'Hexosaminidase A', 'Humans', 'Lysosomes', 'Mice', 'Mice, Knockout', 'Progranulins', 'RAW 264.7 Cells', 'Recombinant Proteins', 'Tay-Sachs Disease'] | 30,341,570 | [['B01.050'], ['A08.186.211'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['A11.329.228'], ['D09.400.410.420.025.475', 'D10.390.470.025.475', 'D10.570.877.360.025.475'], ['A11.251.210.172.750', 'A11.436.334'], ['D08.811.277.450.483.180.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.284.430.214.190.87... | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of stylet-in versus stylet-out collection of cerebrospinal fluid from the cisterna magna on contamination of samples, sample quality, and collection time. | OBJECTIVE: To evaluate safety of stylet-in and stylet-out techniques for collection of CSF from the cisterna magna and to assess whether there were differences between techniques with regard to contamination of samples, sample quality, and efficiency of collection.ANIMALS: 10 adult purpose-bred research Beagles.PROCEDU... | ['Animals', 'Cerebrospinal Fluid', 'Cisterna Magna', 'Cross-Over Studies', 'Dogs', 'Female', 'Male', 'Needles', 'Prospective Studies', 'Specimen Handling', 'Spinal Puncture'] | 31,339,768 | [['B01.050'], ['A12.207.270.210'], ['A08.186.566.166.686.351'], ['E05.318.370.150', 'N05.715.360.325.150', 'N06.850.520.445.150'], ['B01.050.150.900.649.313.750.250.216.200'], ['E07.612'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['E01.370.225.998', 'E05.200.998'], ['E0... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Dietary beta-carotene and cancer of the prostate: a case-control study in Kyoto, Japan. | One hundred patients with prostate cancer and two different control series [100 benign prostatic hyperplasia (BPH) patients and 100 general hospital patients] were matched to each other upon hospital admittance, age (+/- 3 years) and date of admission (+/- 3 months), and directly interviewed during admission from 1981 ... | ['Age Factors', 'Aged', 'Carotenoids', 'Diet', 'Dietary Fats', 'Energy Intake', 'Humans', 'Japan', 'Male', 'Middle Aged', 'Prostatic Hyperplasia', 'Prostatic Neoplasms', 'Risk Factors', 'Vitamin A', 'beta Carotene'] | 2,449,278 | [['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['D02.455.326.271.665.202', 'D02.455.426.392.368.367.379.249', 'D02.455.849.131', 'D23.767.261'], ['G07.203.650.240'], ['D10.212.302', 'G07.203.300.375', 'J02.500.375'], ['G07.203.650.240.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.474.... | ['Health Care [N]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Geographicals [Z]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
Relating the microscopic and macroscopic response of a polymeric fluid in a shearing flow. | The microscopic and macroscopic response of a polymer solution in start-up shear flow was investigated using fluorescence microscopy of single molecules, bulk viscosity measurements, and Brownian dynamics simulations. An overshoot in viscosity was observed upon flow inception and understood via the observed molecular e... | ['Polymers', 'Stress, Mechanical', 'Surface Properties'] | 10,970,672 | [['D05.750', 'D25.720', 'J01.637.051.720'], ['G01.374.835'], ['G02.860']] | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
NADPH oxidases regulate septin-mediated cytoskeletal remodeling during plant infection by the rice blast fungus. | The rice blast fungus Magnaporthe oryzae infects plants with a specialized cell called an appressorium, which uses turgor to drive a rigid penetration peg through the rice leaf cuticle. Here, we show that NADPH oxidases (Nox) are necessary for septin-mediated reorientation of the F-actin cytoskeleton to facilitate cuti... | ['Cytoskeleton', 'Magnaporthe', 'Microscopy, Fluorescence', 'NADPH Oxidases', 'Oryza', 'Reactive Oxygen Species', 'Septins'] | 23,382,235 | [['A11.284.430.214.190.750'], ['B01.300.107.575'], ['E01.370.350.515.458', 'E05.595.458'], ['D08.811.682.608.575', 'D12.776.331.894', 'D12.776.543.653'], ['B01.650.940.800.575.912.250.822.616'], ['D01.339.431', 'D01.650.775'], ['D08.811.277.040.330.300.700', 'D12.776.157.325.757', 'D12.776.220.932']] | ['Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Applying Machine Learning to Linked Administrative and Clinical Data to Enhance the Detection of Homelessness among Vulnerable Veterans. | U.S. military veterans who were discharged from service for misconduct are at high risk for homelessness. Stratifying homelessness risk based on both military service factors and clinical characteristics could facilitate targeted provision of preventive services to those at critical risk. Using administrative data from... | ['Adult', 'Databases as Topic', 'Electronic Health Records', 'Female', 'Homeless Persons', 'Humans', 'Machine Learning', 'Male', 'Management Information Systems', 'Medical Record Linkage', 'Models, Statistical', 'United States', 'United States Department of Veterans Affairs', 'Veterans', 'Veterans Health'] | 30,815,069 | [['M01.060.116'], ['L01.313.500.750.300.188', 'L01.470.750'], ['E05.318.308.940.968.625.500', 'N04.452.859.564.650.125', 'N05.715.360.300.715.500.530.250', 'N06.850.520.308.940.968.625.250'], ['M01.325'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G17.035.250.500', 'L01.224.050.375.530'], ['N04.452.515'], ['E05... | ['Named Groups [M]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
Educating for advocacy: recommendations for professional preparation and development based on a needs and capacity assessment of health education faculty. | An electronic survey was used to conduct a needs and capacity assessment of health education faculty to determine the extent to which advocacy instruction is present in undergraduate and graduate curricula in health education and to identify faculty members' needs and capacity to provide professional preparation and de... | ['Female', 'Health Education', 'Health Educators', 'Health Promotion', 'History, 17th Century', 'Humans', 'Male', 'Needs Assessment', 'Surveys and Questionnaires'] | 18,381,970 | [['I02.233.332', 'N02.421.726.407'], ['M01.526.485.410'], ['I02.233.332.445', 'N02.421.726.407.579'], ['K01.400.504.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I02.594', 'N03.349.380.565', 'N05.300.537'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980']] | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Named Groups [M]', 'Humanities [K]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
[Who benefits from stepwise occupational reintegration provided under the statutory pension insurance scheme?]. | BACKGROUND: Stepwise occupational reintegration (SOR) - since law amendments in April 2004 also provided under the German pension insurance scheme (Deutsche Rentenversicherung, DRV) - is an instrument intended to support insurants on sick-leave in reintegrating into work step by step after long-term illness. In 2008, t... | ['Adult', 'Aged', 'Female', 'Germany', 'Humans', 'Male', 'Middle Aged', 'National Health Programs', 'Pensions', 'Recovery of Function', 'Rehabilitation', 'Rehabilitation, Vocational', 'Sick Leave', 'Young Adult'] | 21,626,465 | [['M01.060.116'], ['M01.060.116.100'], ['Z01.542.315'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['N03.349.550'], ['N01.824.417.510'], ['G16.757'], ['E02.760.169.063.500', 'E02.831', 'H02.403.680.600', 'N02.421.784'], ['E02.760.169.063.500.782', 'E02.831.782', 'N02.421.784.644'], ['N01.824.... | ['Named Groups [M]', 'Geographicals [Z]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
The use of quantitative computed tomography to estimate risk of fracture of the hip from falls. | We conducted an in vitro investigation of the loads and energies needed to fracture the proximal part of the femur in twelve fresh cadavera under loading conditions simulating one particular type of fall. The fracture loads ranged from 778 to 4,040 newtons and the work to fracture, from five to fifty-one joules. We als... | ['Accidental Falls', 'Accidents', 'Aged', 'Aged, 80 and over', 'Biomechanical Phenomena', 'Female', 'Hip Fractures', 'Humans', 'In Vitro Techniques', 'Male', 'Middle Aged', 'Risk', 'Tomography, X-Ray Computed'] | 2,355,030 | [['N06.850.135.122'], ['N06.850.135'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['G01.154.090', 'G01.374.089'], ['C26.404.061.425', 'C26.531.750', 'C26.558.276.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.481'], ['M01.060.116.630'], ['E05.318.740.600.800', 'G17.680.750', 'N05.715.360.750.625.700',... | ['Health Care [N]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The potential mechanism of Bawei Xileisan in the treatment of dextran sulfate sodium-induced ulcerative colitis in mice. | ETHNOPHARMACOLOGICAL RELEVANCE: Bawei Xileisan (BXS), a traditional Chinese compound medicine, has been historically used in the treatment of ulcers and inflammation. BXS is also used as a topical agent for the treatment of ulcerative colitis in China. The underlying mechanism, however, remains elusive.MATERIALS AND ME... | ['Animals', 'Anti-Inflammatory Agents', 'Bacteroides', 'Colitis, Ulcerative', 'Colon', 'Cytokines', 'Dextran Sulfate', 'Disease Models, Animal', 'Dose-Response Relationship, Drug', 'Drugs, Chinese Herbal', 'Feces', 'Female', 'Gastrointestinal Agents', 'Inflammation Mediators', 'Lactobacillus', 'Mice, Inbred C57BL', 'T-... | 27,132,718 | [['B01.050'], ['D27.505.954.158'], ['B03.440.080.094.152', 'B03.440.425.410.194.152'], ['C06.405.205.265.231', 'C06.405.205.731.249', 'C06.405.469.158.188.231', 'C06.405.469.432.249'], ['A03.556.124.526.356', 'A03.556.249.249.356'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['D09.698.365.272.300'], ['C22.2... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Comparison of pseudophakic visual quality in spherical and aspherical intraocular lenses. | OBJECTIVE: This study compares the visual performance of spherical and aspherical intraocular lenses (IOLs) by measuring higher-order aberration and contrast sensitivity (CS) values.DESIGN: Prospective controlled study.PARTICIPANTS: Fifty-seven patients with age-related cataract (61 eyes).METHODS: Patients were randoml... | ['Aged', 'Aged, 80 and over', 'Cataract Extraction', 'Female', 'Follow-Up Studies', 'Humans', 'Lens Implantation, Intraocular', 'Lenses, Intraocular', 'Male', 'Middle Aged', 'Postoperative Period', 'Prospective Studies', 'Prosthesis Design', 'Pseudophakia', 'Visual Acuity'] | 19,491,981 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['E04.540.825.249'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.540.825.600'], ['E07.632.500.460', 'E07.695.460'], ['M01.060.116.630'], ['E04.614.750', 'N02.421.585.753.7... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
LncRNA-CDC6 promotes breast cancer progression and function as ceRNA to target CDC6 by sponging microRNA-215. | Rapid proliferation and metastasis of breast cancers resulted in poor prognosis in clinic. Recent studies have proved that long noncoding RNAs (lncRNAs) were involved in tumor progression. In this study, we aimed to determine the roles and mechanisms of lncRNA-cell division cycle 6 (CDC6) in regulating proliferation an... | ['Breast Neoplasms', 'Cell Cycle Proteins', 'Cell Movement', 'Cell Proliferation', 'Disease Progression', 'Female', 'G1 Phase Cell Cycle Checkpoints', 'Gene Expression Regulation, Neoplastic', 'Humans', 'MCF-7 Cells', 'MicroRNAs', 'Neoplasm Invasiveness', 'Nuclear Proteins', 'RNA, Long Noncoding', 'Signal Transduction'... | 30,362,551 | [['C04.588.180', 'C17.800.090.500'], ['D12.776.167'], ['G04.198', 'G07.568.500.180'], ['G04.161.750', 'G07.345.249.410.750'], ['C23.550.291.656'], ['G04.144.109.249', 'G04.144.500.320.500'], ['G05.308.370'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.251.210.190.630'], ['D13.150.650.319', 'D13.444.735.150.3... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Low dose and gene gun immunization with a hepatitis C virus nonstructural (NS) 3 DNA-based vaccine containing NS4A inhibit NS3/4A-expressing tumors in vivo. | The hepatitis C virus (HCV) protease and helicase encompasses the nonstructural (NS) 3 protein and the cofactor NS4A, which targets the NS3/4A-complex to intracellular membranes. We here evaluate the importance of NS4A in NS3-based genetic immunogens. A full-length genotype 1 NS3/4A gene was cloned into a eucaryotic ex... | ['Animals', 'Biolistics', 'Genetic Therapy', 'Hepacivirus', 'Immunohistochemistry', 'Mice', 'Mice, Inbred BALB C', 'Mice, Inbred C57BL', 'Multiple Myeloma', 'Statistics, Nonparametric', 'T-Lymphocytes, Cytotoxic', 'Th1 Cells', 'Vaccines, DNA', 'Viral Nonstructural Proteins'] | 12,692,597 | [['B01.050'], ['E02.319.267.530.620.570.100', 'E05.393.350.100'], ['E02.095.301', 'E05.393.420.301'], ['B04.450.380', 'B04.820.578.344.475'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512', 'H01.158.201.344.512', 'H01.158.201... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Diseases [C]', 'Health Care [N]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Diaphragm paralysis and ventilatory failure in chronic proximal spinal muscular atrophy. | Ventilatory failure occurred in a patient suffering from proximal neurogenic muscular atrophy resembling the adult form of Kugelberg-Welander syndrome. Diaphragmatic paralysis was diagnosed when patient was found to be unable to generate a transdiaphragmatic pressure difference on deep inspiration. Post-mortem examinat... | ['Adult', 'Back', 'Chronic Disease', 'Diaphragm', 'Humans', 'Male', 'Middle Aged', 'Muscles', 'Muscular Atrophy', 'Respiratory Insufficiency', 'Respiratory Paralysis', 'Spinal Cord'] | 7,224,359 | [['M01.060.116'], ['A01.923.176'], ['C23.550.291.500'], ['A02.633.567.900.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['A02.633', 'A10.690'], ['C10.597.613.612', 'C23.300.070.500', 'C23.888.592.608.612'], ['C08.618.846'], ['C08.618.846.812', 'C10.597.622.812', 'C23.888.592.636.812'], ['... | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Structural heart interventions training in Europe. | BACKGROUND: Structural heart interventions have made major strides over the last years with the introduction of TAVR, percutaneous mitral valve repair and adult congenital heart disease procedures.METHODS: As part of the SCAI SHD Early Career Task Force committee, we complied a survey of 17 questions using a Survey Mon... | ['Cardiac Surgical Procedures', 'Cardiology', 'Clinical Competence', 'Europe', 'Heart Defects, Congenital', 'Humans', 'Internship and Residency', 'Physician Executives', 'Surveys and Questionnaires'] | 26,443,939 | [['E04.100.376', 'E04.928.220'], ['H02.403.429.163'], ['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['Z01.542'], ['C14.240.400', 'C14.280.400', 'C16.131.240.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I02.358.337.350.500', 'I02.358.399.350.750'], ['M01.526.070.700', 'M01.526.485.800', 'N02.360.800'],... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Geographicals [Z]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Improvable quality of diagnostic assessment of colorectal cancer in southern Netherlands. | OBJECTIVE: To determine the extent of guideline implementation of the diagnostic approach in patients with colorectal cancer (CRC) in southern Netherlands in 2005, with special focus on colonoscopy.METHODS: Data were extracted from the medical records for a random sample of 257 colon and 251 rectal cancer patients newl... | ['Adult', 'Aged', 'Aged, 80 and over', 'Colonoscopy', 'Colorectal Neoplasms', 'Female', 'Guideline Adherence', 'Humans', 'Male', 'Middle Aged', 'Neoplasm Staging', 'Netherlands', 'Physical Examination', 'Practice Guidelines as Topic', 'Quality of Health Care', 'Registries', 'Tomography, X-Ray Computed'] | 19,190,499 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E01.370.372.250.250.200', 'E01.370.388.250.250.250.160', 'E04.210.240.250.160', 'E04.502.250.250.250.160'], ['C04.588.274.476.411.307', 'C06.301.371.411.307', 'C06.405.249.411.307', 'C06.405.469.158.356', 'C06.405.469.491.307', 'C06.405.469.860.180'], ['... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Attitudes and practices of dermatologists and primary care physicians who treat patients for MPHL: results of a survey. | OBJECTIVES: The study's objectives were (a) to characterize physicians' attitudes and practices in relation to treating male pattern hair loss (MPHL), (b) to examine differences vis-?-vis physician distinctions, and (c) to consider the findings in relation to published research on MPHL patients' treatment-seeking exper... | ['Alopecia', 'Attitude of Health Personnel', 'Clinical Competence', 'Data Collection', 'Dermatology', 'Female', 'Humans', 'Male', 'Online Systems', 'Patient Satisfaction', 'Physician-Patient Relations', 'Physicians, Family', 'Professional Practice', 'Surveys and Questionnaires'] | 19,968,597 | [['C17.800.329.937.122', 'C23.300.035'], ['F01.100.050', 'N05.300.100'], ['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['E05.318.308', 'L01.399.250', 'N05.715.360.300', 'N06.850.520.308'], ['H02.403.225'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.313.500.750.300.742'], ['F01.100.150.750.625', 'F01.14... | ['Diseases [C]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 |
Endoplasmic reticulum chaperone GRP78 mediates cigarette smoke-induced necroptosis and injury in bronchial epithelium. | Introduction: Bronchial epithelial cell death and airway inflammation induced by cigarette smoke (CS) have been involved in the pathogenesis of COPD. GRP78, belonging to heat shock protein 70 family, has been implicated in cell death and inflammation, while little is known about its roles in COPD. Here, we demonstrate ... | ['Animals', 'Apoptosis', 'Bronchi', 'Cell Line', 'Cytokines', 'Disease Models, Animal', 'Epithelial Cells', 'Heat-Shock Proteins', 'Humans', 'Imidazoles', 'Indoles', 'Inflammation Mediators', 'Lung Injury', 'Mice, Inbred C57BL', 'Mucin 5AC', 'Mucus', 'NF-kappa B', 'Necrosis', 'Pneumonia', 'RNA Interference', 'Signal Tr... | 29,445,274 | [['B01.050'], ['G04.146.954.035'], ['A04.411.125'], ['A11.251.210'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['A11.436'], ['D12.776.580.216'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.383.129.308'], ['D03.633.100.473'], ['D23.469'], ['C08.381.5... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Selective pharyngeal brain cooling]. | Whole-body cooling can be used in the treatment of various brain pathologies, for example, after hypoxic events. Potential complications include haemodynamic instability, coagulation disorders and infection. Selective brain cooling (SBC) would therefore appear to make good sense. In an animal model a new approach to SB... | ['Animals', 'Body Temperature', 'Brain Diseases', 'Catheterization', 'Cold Temperature', 'Cryotherapy', 'Hypothermia, Induced', 'Pharynx', 'Rats', 'Sensitivity and Specificity', 'Somatosensory Cortex'] | 14,661,532 | [['B01.050'], ['E01.370.600.875.374', 'G07.110'], ['C10.228.140'], ['E02.148', 'E05.157'], ['G01.906.595.272', 'G16.500.275.063.725.710.300', 'G16.500.750.775.710.300', 'N06.230.300.100.725.154', 'N06.230.300.100.725.710.300'], ['E02.258'], ['E02.258.750'], ['A03.556.750', 'A04.623', 'A14.724'], ['B01.050.150.900.649.3... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Tannin structural elucidation and quantitative ³?P NMR analysis. 1. Model compounds. | Tannins and flavonoids are secondary metabolites of plants that display a wide array of biological activities. This peculiarity is related to the inhibition of extracellular enzymes that occurs through the complexation of peptides by tannins. Not only the nature of these interactions, but more fundamentally also the st... | ['Anti-Infective Agents', 'Catechin', 'Chemistry, Agricultural', 'Hydrolyzable Tannins', 'Isotope Labeling', 'Models, Chemical', 'Molecular Structure', 'Nuclear Magnetic Resonance, Biomolecular', 'Phosphorus Isotopes', 'Proanthocyanidins', 'Solubility', 'Tannins'] | 24,059,814 | [['D27.505.954.122'], ['D03.383.663.283.240.190', 'D03.383.663.283.266.450.206', 'D03.633.100.150.240.190', 'D03.633.100.150.266.450.206'], ['H01.181.216'], ['D02.241.223.100.300.200.299', 'D02.241.511.390.200.299', 'D02.455.426.559.389.127.281.200.299', 'D02.455.426.559.389.657.410.200.299', 'D05.750.078.937.214'], ['... | ['Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Use of food waste-recycling wastewater as an alternative carbon source for denitrification process: A full-scale study. | Using organic wastes as an alternative to commercial carbon sources could be beneficial by reducing costs and environmental impacts. In this study, food waste-recycling wastewater (FRW) was evaluated as an alternative carbon source for biological denitrification over a period of seven months in a full-scale sewage wast... | ['Bioreactors', 'Carbon', 'Denitrification', 'Nitrogen', 'Sewage', 'Waste Disposal, Fluid', 'Waste Water'] | 28,946,203 | [['E07.115', 'J01.897.120.115'], ['D01.268.150'], ['G02.111.587.250', 'G02.607.560.250', 'G16.500.768.249'], ['D01.268.604', 'D01.362.625'], ['D20.944.932.500'], ['N06.850.780.200.800.800.890', 'N06.850.860.510.900.600.900'], ['D20.944.932', 'N06.850.460.710.865']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Cartilage-wire-fascia compact total ossicular replacement prosthesis in one-stage cholesteatoma surgery. | PURPOSE: Retraction pocket and extrusion of the ossicular prosthesis remain significant problems after tympanoplasty in cholesteatoma surgery. This study presents an alternative surgical technique with a total compact ossicular prosthesis including cartilage, wire, and temporalis fascia.MATERIALS AND METHODS: A total o... | ['Adolescent', 'Adult', 'Audiometry', 'Cartilage', 'Child', 'Child, Preschool', 'Cholesteatoma, Middle Ear', 'Cohort Studies', 'Fascia', 'Fasciotomy', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Middle Aged', 'Ossicular Prosthesis', 'Ossicular Replacement', 'Otoscopy', 'Postoperative Care', 'Postoperative Complic... | 19,144,300 | [['M01.060.057'], ['M01.060.116'], ['E01.370.382.375.060'], ['A02.165', 'A10.165.382'], ['M01.060.406'], ['M01.060.406.448'], ['C09.218.200', 'C17.800.428.260.300'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['A02.340', 'A10.165.425'], ['E04.321'], ['E05.318.372.500.750.249', 'N05.7... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
In silico method for identification of novel copper and iron metabolism proteins in various neurodegenerative disorders. | Copper (Cu) and Iron (Fe) has been the subject of intensive research over several decades as numerous seminal studies robustly support the involvement of Cu and Fe metabolism dyshomeostasis as a common denominator in several neurodegenerative disorders (particularly Alzheimer's disease and Parkinson's disease); however... | ['Brain', 'Computational Biology', 'Computer Simulation', 'Databases, Protein', 'Factor V', 'Factor VII', 'Humans', 'Nerve Degeneration', 'Neurodegenerative Diseases', 'Osteonectin', 'Protein Interaction Maps', 'Signal Transduction'] | 30,831,127 | [['A08.186.211'], ['H01.158.273.180', 'L01.313.124'], ['L01.224.160'], ['L01.313.500.750.300.188.400.300.750', 'L01.313.500.750.300.188.400.325.710', 'L01.470.750.750.300.750', 'L01.470.750.750.325.710'], ['D12.776.124.125.300', 'D12.776.811.272', 'D23.119.300'], ['D08.622.432', 'D12.776.124.125.325', 'D12.776.811.243.... | ['Anatomy [A]', 'Disciplines and Occupations [H]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Thiol-sensitive sites in cell adhesion. Decreased entry of SH-binding reagents into attached BHK cells. | Studies were carried out to learn more about the critical SH groups involved in cell spreading. Pretreatment of suspended baby hamster kidney (BHK) cells with 3 mM-iodoacetate or iodoacetamide for 10 min at 4 degrees C completely inhibited the ability of the cells to spread on fibronectin-coated substrata. If, however,... | ['Animals', 'Binding Sites', 'Cell Adhesion', 'Cell Line', 'Cell Membrane Permeability', 'Chromatography, Ion Exchange', 'Cricetinae', 'Iodoacetamide', 'Iodoacetates', 'Iodoacetic Acid', 'Kidney', 'Sulfhydryl Compounds'] | 7,159,413 | [['B01.050'], ['G02.111.570.120'], ['G04.022'], ['A11.251.210'], ['G03.143.335', 'G04.175'], ['E05.196.181.400.383'], ['B01.050.150.900.649.313.992.635.075.250'], ['D02.065.064.400', 'D02.241.081.018.110.400', 'D02.241.081.018.487.249', 'D02.455.526.581.247.249'], ['D02.241.081.018.487', 'D02.455.526.581.247'], ['D02.2... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Gluten and the small intestine in rheumatoid arthritis. | A study of the small intestine in patients with rheumatoid arthritis was undertaken because it has been suggested that the disease arises secondary to hereditary enteropathy. No abnormality of jejunal mucosa was detected histologically in five patients with arthritis, and studies of bowel function were normal in six pa... | ['Adult', 'Arthritis, Rheumatoid', 'Biopsy', 'Female', 'Glutens', 'Humans', 'Jejunum', 'Male', 'Middle Aged'] | 12,608,175 | [['M01.060.116'], ['C05.550.114.154', 'C05.799.114', 'C17.300.775.099', 'C20.111.199'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['D12.776.765.433.500.500', 'D12.776.765.725.500.500'], ['B01.050.150.900.649.313.988.400... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Deficiency of vitamin E in the alveolar fluid of cigarette smokers. Influence on alveolar macrophage cytotoxicity. | Cigarette smoking produces oxidant-mediated changes in the lung important to the pathogenesis of emphysema. Since vitamin E can neutralize reactive oxygen species and prevent peroxidation of unsaturated lipids, it may constitute an important component of the lung's defense against oxidant injury. To better characterize... | ['Cell Survival', 'Humans', 'Macrophages', 'Pulmonary Alveoli', 'Smoking', 'Vitamin E', 'Vitamin E Deficiency'] | 3,949,977 | [['G04.346'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.329.372', 'A11.627.482', 'A11.733.397', 'A15.382.670.522', 'A15.382.680.397'], ['A04.411.715'], ['F01.145.805'], ['D03.383.663.283.909', 'D03.633.100.150.909'], ['C18.654.521.500.133.841']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Pilot study of the mechanism of action of preoperative trastuzumab in patients with primary operable breast tumors overexpressing HER2. | PURPOSE: To elucidate the mechanism by which trastuzumab, a humanized monoclonal antibody against HER2 with proven survival benefit in women with HER2-positive metastatic breast cancer, mediates its antitumor activity.EXPERIMENTAL DESIGN: A pilot study including 11 patients with HER2-positive tumors treated in a neo-ad... | ['Antibodies, Monoclonal', 'Antibodies, Monoclonal, Humanized', 'Antibody-Dependent Cell Cytotoxicity', 'Antineoplastic Agents', 'Breast Neoplasms', 'Cell Proliferation', 'Female', 'Humans', 'Lymphocytes', 'Neoadjuvant Therapy', 'Pilot Projects', 'Preoperative Care', 'Receptor, ErbB-2', 'Remission Induction', 'Trastuzu... | 15,355,889 | [['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D12.776.124.486.485.114.224.060', 'D12.776.124.790.651.114.224.060', 'D12.776.377.715.548.114.224.200'], ['G12.287.070'], ['D27.505.954.248'], ['C04.588.180', 'C17.800.090.500'], ['G04.161.750', 'G07.345.249.410.750'], ['B... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[Aortopexy for tracheomalacia in infants and children]. | During the past 12 years (1985-1998), 28 infants and children were operated on here for tracheomalacia. The diagnosis was made in all using rigid bronchoscopy. During the examination the infants breathed spontaneously, but the trachea collapsed on forced expiration. Indications for surgery were repeated cyanotic spells... | ['Aorta, Thoracic', 'Child, Preschool', 'Humans', 'Infant', 'Infant, Newborn', 'Laryngeal Cartilages', 'Retrospective Studies', 'Tracheal Diseases'] | 10,979,425 | [['A07.015.114.056.372'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['A02.165.257.625', 'A02.165.407.500', 'A04.329.591'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.520.4... | ['Anatomy [A]', 'Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The power of confession: the role of the criminal law and courtpractices in the production of knowledge concerning sexuality between women: Finland, in the 1950s. | The article discusses a number of court cases on women's same-sex fornication in the Finnish countryside in the 1950s. Based on a close reading of the minutes of the police investigations and the court records, the article shows how the notion of sexual acts between women, and the notion of certain modes of conduct as ... | ['Female', 'History, 20th Century', 'Homosexuality, Female', 'Humans', 'Jurisprudence', 'Sweden'] | 9,638,560 | [['K01.400.504.968'], ['F01.145.802.975.500.400', 'G08.686.867.500.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I01.880.604.583', 'N03.706.535'], ['Z01.542.816.500']] | ['Humanities [K]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
A novel computer aided breast mass detection scheme based on morphological enhancement and SLIC superpixel segmentation. | PURPOSE: To develop a computer-aided detection (CAD) scheme for mass detection on digitized mammograms that achieves a high sensitivity while maintaining a low false positive (FP) rate using morphological enhancement and simple linear iterative clustering (SLIC) method.METHODS: The authors developed a multiple stage me... | ['Breast', 'Breast Diseases', 'Cluster Analysis', 'Databases, Factual', 'Datasets as Topic', 'Humans', 'Image Interpretation, Computer-Assisted', 'Linear Models', 'Mammography', 'ROC Curve', 'Sensitivity and Specificity', 'Support Vector Machine'] | 26,133,587 | [['A01.236'], ['C17.800.090'], ['E05.318.740.250', 'N05.715.360.750.200', 'N06.850.520.830.250'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['E05.318.308.056', 'L01.313.500.750.300.188.400.500', 'L01.399.250.224', 'L01.470.750.750.431', 'N05.715.360.300.224', 'N06.850.520.308.056'], ['B01.050.150.900.649.313.... | ['Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Information Science [L]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Anabolic steroid abuse causing recurrent hepatic adenomas and hemorrhage. | Anabolic steroid abuse is common among athletes and is associated with a number of medical complications. We describe a case of a 27-year-old male bodybuilder with multiple hepatic adenomas induced by anabolic steroids. He initially presented with tumor hemorrhage and was treated with left lateral hepatic segmentectomy... | ['Adenoma', 'Adult', 'Anabolic Agents', 'Hemorrhage', 'Humans', 'Liver Neoplasms', 'Male', 'Neoplasm Recurrence, Local', 'Steroids', 'Substance-Related Disorders'] | 18,680,242 | [['C04.557.470.035'], ['M01.060.116'], ['D27.505.696.399.472.080'], ['C23.550.414'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.274.623', 'C06.301.623', 'C06.552.697'], ['C04.697.655', 'C23.550.727.655'], ['D04.210.500'], ['C25.775', 'F03.900']] | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Left ventricular diastolic function abnormalities in hypopituitary patients with GH deficiency: evidence for a subclinical cardiomyopathy. | The aim of this study was to evaluate cardiac performance, in particular diastolic function, in adult patients with adulthood onset GH deficiency. The study group was composed of 19 GH deficient adult hypopituitary patients with at-least 3 additional pituitary hormone deficits and 19 age, sex and BMI matched healthy co... | ['Adult', 'Blood Glucose', 'Body Composition', 'Cardiomyopathies', 'Cholesterol, LDL', 'Diastole', 'Electric Impedance', 'Female', 'Human Growth Hormone', 'Humans', 'Hypopituitarism', 'Insulin-Like Growth Factor I', 'Lipids', 'Male', 'Middle Aged', 'Systole', 'Ultrasonography', 'Ventricular Dysfunction, Left'] | 12,150,332 | [['M01.060.116'], ['D09.947.875.359.448.500'], ['G02.111.130', 'G03.180', 'G07.100.049'], ['C14.280.238'], ['D04.210.500.247.808.197.244', 'D10.532.515.500', 'D10.570.938.208.275', 'D12.776.521.550.500'], ['G09.330.580.295', 'G11.427.494.554.250', 'G11.427.494.570.295'], ['G01.358.500.249.277.350'], ['D06.472.699.631.5... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Observation on twins of cosmic radiation influence as a risk factor]. | UNLABELLED: During flight, cosmic radiation is capable to penetrate the walls of airplanes and produce mutations in human chromosomes.AIM: To evaluate the correlations between cosmic radiation and the pathology of flying personnel.MATERIAL AND METHOD: Two twin patients, one with 15 years work as a flight crew member, a... | ['Adult', 'Aircraft', 'Aviation', 'Chromosomes, Human', 'Cosmic Radiation', 'Female', 'Genetic Testing', 'Humans', 'Hypercholesterolemia', 'Mothers', 'Occupational Diseases', 'Occupational Exposure', 'Pedigree', 'Risk Factors', 'Twins, Dizygotic'] | 20,191,877 | [['M01.060.116'], ['J01.937.285.100'], ['J01.937.285'], ['A11.284.187.520.300', 'G05.360.162.520.300'], ['G01.060.185', 'G01.750.750.235', 'G16.500.200', 'N06.230.300.100.300'], ['E01.370.225.562', 'E05.200.562', 'E05.393.435', 'N02.421.308.430', 'N02.421.726.233.221'], ['B01.050.150.900.649.313.988.400.112.400.400'], ... | ['Named Groups [M]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phe... | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 |
Regulation of KIF1A-Driven Dense Core Vesicle Transport: Ca2+ | Tight regulation of neuronal transport allows for cargo binding and release at specific cellular locations. The mechanisms by which motor proteins are loaded on vesicles and how cargoes are captured at appropriate sites remain unclear. To better understand how KIF1A-driven dense core vesicle (DCV) transport is regulate... | ['Adaptor Proteins, Signal Transducing', 'Animals', 'Calcium', 'Calmodulin', 'Dendritic Spines', 'HEK293 Cells', 'Humans', 'Intracellular Signaling Peptides and Proteins', 'Kinesin', 'Mutation', 'Nerve Tissue Proteins', 'Protein Binding', 'Rats, Wistar', 'Secretory Vesicles', 'Synapses'] | 30,021,165 | [['D12.644.360.024', 'D12.776.157.057', 'D12.776.476.024'], ['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D12.644.360.372.249', 'D12.776.157.125.412.249', 'D12.776.476.387.249'], ['A08.675.256.200', 'A11.284.180.225.169', 'A11.671.240.169'], ['A11.251.210.172.750', 'A11.436.334'], ['B01.050.150.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Increased expression of the multidrug resistance-associated protein 1 (MRP1) in kidney glomeruli of streptozotocin-induced diabetic rats. | Oxidative stress has been linked to the podocytopathy, mesangial expansion and progression of diabetic nephropathy. The major cell defence mechanism against oxidative stress is reduced glutathione (GSH). Some ABC transporters have been shown to extrude GSH, oxidised glutathione or their conjugates out of the cell, thus... | ['Animals', 'Diabetes Mellitus, Experimental', 'Glutathione', 'Kidney Glomerulus', 'Male', 'Multidrug Resistance-Associated Proteins', 'Oxidative Stress', 'Propionates', 'Quinolines', 'RNA, Messenger', 'Rats', 'Rats, Sprague-Dawley', 'Reverse Transcriptase Polymerase Chain Reaction', 'Streptozocin', 'Structure-Activity... | 21,495,913 | [['B01.050'], ['C18.452.394.750.074', 'C19.246.240', 'E05.598.500.374'], ['D12.644.456.448'], ['A05.810.453.324.359', 'A05.810.453.736.520'], ['D12.776.157.530.100.304', 'D12.776.157.530.450.074.500.500.500', 'D12.776.543.585.100.304', 'D12.776.543.585.450.074.500.500.500'], ['G03.673', 'G07.775.750'], ['D02.241.081.75... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Enhanced immunogenicity of gp120 protein when combined with recombinant DNA priming to generate antibodies that neutralize the JR-FL primary isolate of human immunodeficiency virus type 1. | Strategies are needed for human immunodeficiency virus type 1 vaccine development that improves the neutralizing antibody response against primary isolates of the virus. Here we examined recombinant DNA priming followed by subunit protein boosting as a strategy to generate neutralizing antibodies. Both plasmid-based an... | ['AIDS Vaccines', 'Animals', 'DNA, Recombinant', 'HIV Antibodies', 'HIV Envelope Protein gp120', 'HIV Infections', 'HIV-1', 'Humans', 'Immunization', 'Neutralization Tests', 'Rabbits', 'Vaccines, DNA'] | 15,919,951 | [['D20.215.894.899.050'], ['B01.050'], ['D13.444.308.460'], ['D12.776.124.486.485.114.254.150.440', 'D12.776.124.790.651.114.254.150.440', 'D12.776.377.715.548.114.254.150.440'], ['D12.776.964.775.325.164.249', 'D12.776.964.775.562.500.500', 'D12.776.964.970.880.325.164.249', 'D23.050.327.520.350'], ['C01.221.250.875',... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Probing of CD4 binding pocket of HIV-1 gp120 glycoprotein using unnatural phenylalanine analogues. | CD4-gp120 interaction is the first step for HIV-1 entry into host cells. A highly conserved pocket in gp120 protein is an attractive target for developing gp120 inhibitors or novel HIV detection tools. Here we incorporate seven phenylalanine derivatives having different sizes and steric conformations into position 43 o... | ['Binding Sites', 'CD4 Antigens', 'HIV Envelope Protein gp120', 'Humans', 'Models, Molecular', 'Molecular Structure', 'Phenylalanine', 'Protein Conformation'] | 25,453,804 | [['G02.111.570.120'], ['D12.776.543.750.705.852.420.810.500', 'D12.776.543.750.830.700.025', 'D23.050.301.264.894.100', 'D23.101.100.894.100'], ['D12.776.964.775.325.164.249', 'D12.776.964.775.562.500.500', 'D12.776.964.970.880.325.164.249', 'D23.050.327.520.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Sequencing, tissue distribution and chromosomal assignment of a novel ubiquitin-specific protease USP23. | We have identified human and mouse cDNAs encoding a novel ubiquitin-specific protease designated USP23. Both cDNAs encode a 62-kDa protein containing the highly conserved His and Cys domains characteristic of the C19 cysteine protease family of ubiquitin-specific processing proteases (UCH-2). Human tissue Northern blot... | ['Amino Acid Sequence', 'Animals', 'Base Sequence', 'Carbon-Nitrogen Lyases', 'Chromosome Mapping', 'Cysteine Endopeptidases', 'Gene Expression', 'Humans', 'Mice', 'Molecular Sequence Data', 'Sequence Alignment', 'Sequence Homology', 'Ubiquitin Thiolesterase'] | 10,786,635 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D08.811.520.232'], ['E05.393.183'], ['D08.811.277.656.262.500', 'D08.811.277.656.300.200'], ['G05.297'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649.313.992.635.505.500'], ['... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Gastroprotective activity of epitaondiol and sargaol. | The effects of epitaondiol (1) and sargaol (2), isolated from the brown alga Stypopodium flabelliforme on HCl/ethanol-induced gastric lesions in mice were evaluated and compared with that of lansoprazole. Epitaondiol and sargaol (6.25 - 50 mg/kg) dose-dependently inhibited the appearance of gastric lesions in mice, dis... | ['2-Pyridinylmethylsulfinylbenzimidazoles', 'Animals', 'Anti-Ulcer Agents', 'Ethanol', 'Hydrochloric Acid', 'Lansoprazole', 'Mice', 'Molecular Structure', 'Phaeophyta', 'Phytotherapy', 'Plant Extracts', 'Stomach Ulcer', 'Terpenes'] | 21,922,901 | [['D02.886.640.074', 'D03.383.725.024', 'D03.633.100.103.034'], ['B01.050'], ['D27.505.954.483.203'], ['D02.033.375'], ['D01.029.260.326', 'D01.210.450'], ['D02.886.640.074.249', 'D03.383.725.024.249', 'D03.633.100.103.034.249'], ['B01.050.150.900.649.313.992.635.505.500'], ['G02.111.570', 'G02.466'], ['B01.750.600'], ... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Increased frequency of chromosome aberrations in long-term cultured cerebrospinal fluid lymphocytes of patients with multiple sclerosis. | A method employing long-term lymphocyte culturing was developed to study chromosome aberrations in samples with very few cells. It was used to examine lymphocytes from the cerebrospinal fluid (CSF) and peripheral blood (PB) in 23 patients with clinically definite multiple sclerosis (MS), nine patients with other neurol... | ['Adult', 'Aged', 'Blood Cells', 'Cells, Cultured', 'Cerebrospinal Fluid', 'Chromosome Aberrations', 'Female', 'Humans', 'Lymphocytes', 'Male', 'Middle Aged', 'Multiple Sclerosis', 'Nervous System Diseases'] | 1,856,732 | [['M01.060.116'], ['M01.060.116.100'], ['A11.118', 'A15.145.229'], ['A11.251'], ['A12.207.270.210'], ['C23.550.210', 'G05.365.590.175'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.118.637.555.567', 'A15.145.229.637.555.567', 'A15.382.490.555.567'], ['M01.060.116.630'], ['C10.114.375.500', 'C10.314.350.500',... | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Aphrodisiac Activity of the Aqueous Crude Extract of Purple Corn ( Zea mays) in Male Rats. | In the present study, the aphrodisiac properties of the purple corn ( Zea mays) in male rats were analyzed. The aqueous crude extract of purple corn (at 25, 50, and 75 mg/kg) was administered to ( a) copulating male rats and ( b) anesthetized and spinal cord transected male rats. Behavioral parameters of copulatory beh... | ['Animals', 'Aphrodisiacs', 'Copulation', 'Male', 'Motor Activity', 'Plant Extracts', 'Rats', 'Rats, Wistar', 'Sexual Behavior, Animal', 'Zea mays'] | 28,508,664 | [['B01.050'], ['D27.505.696.282.045', 'D27.505.954.427.220.045'], ['F01.145.113.252.748.200'], ['F01.145.632', 'G11.427.410.698'], ['D20.215.784.500', 'D26.667'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.900'], ['F01.145.113.252.748'], ['B01.650.940.800.575.912.250.822.966'... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Stabilization of influenza vaccine enhances protection by microneedle delivery in the mouse skin. | BACKGROUND: Simple and effective vaccine administration is particularly important for annually recommended influenza vaccination. We hypothesized that vaccine delivery to the skin using a patch containing vaccine-coated microneedles could be an attractive approach to improve influenza vaccination compliance and efficac... | ['Animals', 'Drug Delivery Systems', 'Female', 'Immunoglobulin G', 'Influenza Vaccines', 'Injections, Intradermal', 'Injections, Intramuscular', 'Mice', 'Mice, Inbred BALB C', 'Needles', 'Skin', 'Trehalose', 'Vaccination'] | 19,779,615 | [['B01.050'], ['E02.319.300'], ['D12.776.124.486.485.114.619.393', 'D12.776.124.790.651.114.619.393', 'D12.776.377.715.548.114.619.393'], ['D20.215.894.899.302'], ['E02.319.267.530.620.410'], ['E02.319.267.530.460'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.338', 'B01.050.150.900.649.313.9... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
mRNA stability is regulated by a coding-region element and the unique 5' untranslated leader sequences of the three Synechococcus psbA transcripts. | The psbAI and psbAIII transcripts in Synechococcus sp. strain PCC 7942 are subject to accelerated turnover when cells are exposed to high light intensities, but psbAII message stability is unaffected. We used a psbAI 'minigene' which has a part of the coding sequence removed as a reporter gene in order to identify the ... | ['Cyanobacteria', 'Genes, Bacterial', 'Photosynthetic Reaction Center Complex Proteins', 'Photosystem II Protein Complex', 'Protein Biosynthesis', 'RNA Processing, Post-Transcriptional', 'RNA, Bacterial', 'RNA, Messenger', 'Ribosomes'] | 9,218,763 | [['B03.280', 'B03.440.475.100'], ['G05.360.340.024.340.364.249', 'G05.360.340.358.024.249', 'G05.360.340.358.207.249'], ['D05.500.562.488', 'D08.811.600.710', 'D12.776.543.930.500', 'D12.776.765.199.750.750'], ['D05.500.562.488.750', 'D08.811.600.710.750', 'D12.776.543.930.500.750', 'D12.776.765.199.750.750.750'], ['G0... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Enzyme recovery during gas/liquid two-phase flow microfiltration of enzyme/yeast mixtures. | The effect of a gas/liquid two-phase flow on the recovery of an enzyme was evaluated and compared with standard crossflow operation when confronted with the microfiltration of a high-fouling yeast suspension. Ceramic tubular and flat sheet membranes were used. At constant feed concentration (permeate recycling) and tra... | ['Adsorption', 'Colloids', 'Enzyme Stability', 'Enzymes', 'Gases', 'Glycoside Hydrolases', 'Membranes, Artificial', 'Permeability', 'Powders', 'Quality Control', 'Reproducibility of Results', 'Restriction Mapping', 'Saccharomyces cerevisiae', 'Sensitivity and Specificity', 'Solutions', 'Ultrafiltration', 'beta-Fructofu... | 12,378,602 | [['G01.030', 'G02.020'], ['D20.280', 'D26.255.165'], ['E05.916.360', 'G02.111.700.500'], ['D08.811'], ['D01.362'], ['D08.811.277.450'], ['D25.479', 'J01.637.051.479', 'J01.637.087.500'], ['G02.723'], ['D26.255.779'], ['J01.897.608'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['E0... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Sodium sensitivity in human subjects. Hemodynamic and hormonal correlates. | To investigate factors associated with sodium sensitivity, 157 subjects were studied while receiving 10 and 200 mEq sodium diets. Measurements included blood pressure (BP), forearm vascular resistance, plasma renin activity (PRA), and plasma aldosterone. Sodium repletion was associated with a greater than 5% increase i... | ['Adult', 'Aldosterone', 'Female', 'Hemodynamics', 'Humans', 'Hypertension', 'Male', 'Renin', 'Sodium, Dietary'] | 3,292,416 | [['M01.060.116'], ['D04.210.500.745.745.654.062', 'D06.472.040.585.353.118'], ['G09.330.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['D08.811.277.656.074.500.780', 'D08.811.277.656.300.048.780', 'D08.811.277.656.837.750'], ['D01.857.875']] | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Radiolytic degradation of atrazine aqueous solution containing humic substances. | Degradation of atrazine herbicide in humic substances (HS) aqueous solutions and distilled water solutions was investigated on a laboratory scale upon gamma-irradiation from a (60)Co source. In addition, the effect of ionizing radiation on the atrazine residues removal efficiency was investigated in relation to degrada... | ['Atrazine', 'Decontamination', 'Dose-Response Relationship, Radiation', 'Environmental Monitoring', 'Environmental Restoration and Remediation', 'Gamma Rays', 'Gas Chromatography-Mass Spectrometry', 'Herbicides', 'Humic Substances', 'Pesticide Residues', 'Water Pollutants, Chemical', 'Water Purification'] | 18,597,846 | [['D03.383.931.247'], ['N06.850.780.325'], ['E05.799.513.500', 'G01.750.740.500', 'G04.712.500', 'G07.225', 'G07.738.500', 'N06.850.810.250.180'], ['N06.850.460.350.080', 'N06.850.780.375'], ['N06.230.080.600', 'N06.850.460.375'], ['G01.358.500.505.300', 'G01.750.250.300', 'G01.750.750.400'], ['E05.196.181.349.500', 'E... | ['Chemicals and Drugs [D]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[A case of massive hemorrhagic enteritis due to rotavirus]. | We described a 8-month-old boy of massive hemorrhagic enteritis due to rotavirus complicated by shock. As far as we know, this case is the first patient who developed vascular collapse from the gastrointestinal tract bleeding by rotavirus infection. Clinicians should be alerted to the possibility of the occurrence of s... | ['Enteritis', 'Gastrointestinal Hemorrhage', 'Humans', 'Infant', 'Male', 'Rotavirus', 'Rotavirus Infections', 'Shock, Hemorrhagic'] | 2,170,542 | [['C06.405.205.462', 'C06.405.469.326'], ['C06.405.227', 'C23.550.414.788'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['B04.820.223.719.790'], ['C01.925.782.791.814'], ['C23.550.414.980', 'C23.550.835.650']] | ['Diseases [C]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Acute urinary retention after transperineal template-guided prostate biopsy. | PURPOSE: Urinary retention occurs in 5%-36% of patients with prostate cancer after implantation of radioactive seeds for brachytherapy. We used transperineal biopsy as a model to determine the influence of needle trauma on urinary retention.METHODS AND MATERIAL: We retrospectively reviewed medical records of 157 men wi... | ['Acute Disease', 'Age Factors', 'Aged', 'Aged, 80 and over', 'Biopsy, Needle', 'Humans', 'Logistic Models', 'Male', 'Middle Aged', 'Multivariate Analysis', 'Prostate', 'Prostatic Neoplasms', 'Retrospective Studies', 'Ultrasonography, Interventional', 'Urinary Retention'] | 15,275,721 | [['C23.550.291.125'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E01.370.225.500.384.100.119', 'E01.370.225.998.054.119', 'E01.370.388.100.100', 'E04.074.119', 'E04.665.100', 'E05.200.500.384.100.119', 'E05.200.998.054.119', 'E05.242.384.100.119'], ['B01.050.150.900.649.313.... | ['Diseases [C]', 'Health Care [N]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Transfers for Hand Surgery Correlate with Increased Reoperations for Complications. | Wrist, hand, and finger trauma are the most common nonlethal injuries presenting to emergency departments. In Tennessee, lack of available hand care, particularly the need for emergency hand surgery, could be detrimental to patient outcomes. This is a retrospective outcomes study of patients requiring revisional hand s... | ['Emergency Medical Services', 'Hand Injuries', 'Health Services Accessibility', 'Humans', 'Income', 'Postoperative Complications', 'Reoperation', 'Residence Characteristics', 'Retrospective Studies', 'Tennessee'] | 26,672,590 | [['N02.421.297'], ['C26.448'], ['N04.590.374.350', 'N05.300.430'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N01.824.417'], ['C23.550.767'], ['E04.690'], ['N01.224.791', 'N06.850.505.400.800'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', ... | ['Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
The citalopram challenge test in patients with major depression and in healthy controls. | Neuroendocrine challenge tests in depressed patients have revealed a blunted hormonal reaction to serotonergic stimuli. In the present study, citalopram was chosen as the serotonergic agent for neuroendocrine stimulation. Compared to earlier challenge agents, citalopram has the advantage of serotonergic selectivity, it... | ['Acute Disease', 'Adult', 'Case-Control Studies', 'Citalopram', 'Depressive Disorder, Major', 'Female', 'Humans', 'Hydrocortisone', 'Male', 'Middle Aged', 'Predictive Value of Tests', 'Prolactin', 'Serotonin', 'Serotonin Uptake Inhibitors'] | 10,622,344 | [['C23.550.291.125'], ['M01.060.116'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['D02.092.831.170', 'D02.626.320', 'D03.633.100.127.187'], ['F03.600.300.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D04.210.500.745.745.654.600', 'D06.472.040.585.353.476', 'D06.472.040.5... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Training in pregnant women: effects on fetal development and birth. | OBJECTIVE: The effects of high- and medium-intensity exercise on the fetus and on the onset and length of labor, birth weight, and Apgar score were studied in healthy athletes who performed a high level of exercise before conception.STUDY DESIGN: Forty-two women were recruited to the study by newspaper ads and through ... | ['Adult', 'Apgar Score', 'Birth Weight', 'Embryonic and Fetal Development', 'Exercise', 'Female', 'Gestational Age', 'Humans', 'Labor, Obstetric', 'Male', 'Physical Fitness', 'Pregnancy', 'Retrospective Studies', 'Sex Characteristics', 'Sports', 'Weight Gain'] | 9,500,487 | [['M01.060.116'], ['E01.370.600.050'], ['C23.888.144.186', 'E01.370.600.115.100.160.120.186', 'E05.041.124.160.750.149', 'G07.100.100.160.120.186', 'G07.345.249.314.120.186'], ['G07.345.500.325', 'G08.686.784.170'], ['G11.427.410.698.277', 'I03.350'], ['G07.345.500.325.235.968', 'G08.686.320'], ['B01.050.150.900.649.31... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Reliability of in vivo neutron activation analysis for measuring body composition: comparisons with tracer dilution and dual-energy x-ray absorptiometry. | In vivo neutron activation (IVNA) analysis has the capacity to measure several total body elements in human subjects. Although it has been considered a criterion method for the past 3 decades, the reliability of IVNA analysis has been tested only in phantom calibrations. In 5 male weight-stable patients with AIDS, tota... | ['Absorptiometry, Photon', 'Acquired Immunodeficiency Syndrome', 'Adult', 'Body Composition', 'Body Water', 'Bromides', 'Calcium', 'Deuterium', 'Extracellular Space', 'Humans', 'Male', 'Neutron Activation Analysis', 'Radioisotope Dilution Technique', 'Sodium Compounds', 'Sulfates', 'Sulfur Radioisotopes', 'Tritium'] | 8,621,978 | [['E01.370.350.700.024', 'E05.196.712.224.187'], ['C01.221.250.875.040', 'C01.221.812.640.400.040', 'C01.778.640.400.040', 'C01.925.782.815.616.400.040', 'C01.925.813.400.040', 'C01.925.839.040', 'C20.673.480.040'], ['M01.060.116'], ['G02.111.130', 'G03.180', 'G07.100.049'], ['A12.207.200'], ['D01.139.300.050', 'D01.24... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Neuromas of the facial nerve. | Forty-eight patients with facial nerve neuromas were treated at the Otologic Medical Group Inc. between 1974 and 1985. The most common presenting symptoms were hearing loss and tinnitus. Facial paralysis occurred in 22 patients (46%). A mass behind the tympanic membrane was seen on otoscopy in 14 patients (29%). These ... | ['Adolescent', 'Adult', 'Aged', 'Child', 'Child, Preschool', 'Cranial Nerve Neoplasms', 'Facial Nerve Diseases', 'Facial Paralysis', 'Female', 'Hearing Disorders', 'Humans', 'Infant', 'Male', 'Middle Aged', 'Neuroma', 'Tinnitus', 'Tomography, X-Ray Computed'] | 2,719,087 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.406'], ['M01.060.406.448'], ['C04.588.614.300', 'C04.588.614.596.240', 'C10.292.225', 'C10.551.360', 'C10.551.775.250'], ['C07.465.299', 'C10.292.319'], ['C07.465.327', 'C10.597.622.214', 'C23.888.592.636.214'], ['C09.218.458', 'C10.597.751.418', 'C23.88... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Diverse effects of ANXA7 and p53 on LNCaP prostate cancer cells are associated with regulation of SGK1 transcription and phosphorylation of the SGK1 target FOXO3A. | Tumor suppressor function of the calcium/phospholipid-binding Annexin-A7 (ANXA7) has been shown in Anxa7-deficient mice and validated in human cancers. In the androgen-resistant prostate cancer cells, ANXA7 and p53 showed similar cytotoxicity levels. However, in the androgen-sensitive LNCaP, ANXA7 greatly exceeded the ... | ['Androgens', 'Animals', 'Annexin A7', 'Base Sequence', 'Cell Count', 'Cell Cycle', 'Cell Death', 'Cell Line, Tumor', 'Cell Survival', 'Forkhead Box Protein O3', 'Forkhead Transcription Factors', 'Gene Expression Regulation, Neoplastic', 'Humans', 'Immediate-Early Proteins', 'Isoenzymes', 'Male', 'Mice', 'Molecular Seq... | 24,864,229 | [['D27.505.696.399.472.161'], ['B01.050'], ['D12.776.157.125.050.120'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E01.370.225.500.195', 'E05.200.500.195', 'E05.242.195', 'G04.140'], ['G04.144'], ['G04.146'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.346'], ['D12.776.260.950.249.125', 'D12.776.930... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Identification of Dlk1, Ptpru and Klhl1 as novel Nurr1 target genes in meso-diencephalic dopamine neurons. | The orphan nuclear receptor Nurr1 is essential for the development of meso-diencephalic dopamine (mdDA) neurons and is required, together with the homeobox transcription factor Pitx3, for the expression of genes involved in dopamine metabolism. In order to elucidate the molecular mechanisms that underlie the neuronal d... | ['Animals', 'Base Sequence', 'Binding Sites', 'Calcium-Binding Proteins', 'Cell Differentiation', 'Cells, Cultured', 'DNA Primers', 'DNA-Binding Proteins', 'Diencephalon', 'Dopamine', 'Dopamine Plasma Membrane Transport Proteins', 'Female', 'Gene Expression Regulation, Developmental', 'Homeodomain Proteins', 'Intercell... | 19,515,692 | [['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G02.111.570.120'], ['D12.776.157.125'], ['G04.152'], ['A11.251'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['D12.776.260'], ['A08.186.211.200.317'], ['D02.092.211.215.406', 'D02.092.311.342', 'D02.455.426.559.389.657.166.175.3... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Changing organisations: a study of the context and processes of mergers of health care providers in England. | This paper presents findings from a study of the context and processes of provider mergers in the NHS in England. Mergers are an example of organisational restructuring, a key lever for change in the UK health care sector and elsewhere, although it is only one strategy for organisational change. The framework for the s... | ['England', 'Health Facility Merger', 'Health Personnel', 'Humans', 'Mental Health Services', 'Organizational Innovation', 'Organizational Objectives', 'State Medicine'] | 15,482,872 | [['Z01.542.363.300'], ['N02.278.235'], ['M01.526.485', 'N02.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F04.408', 'N02.421.461'], ['N04.452.610'], ['N04.452.615'], ['N03.349.550.902', 'N03.858']] | ['Geographicals [Z]', 'Health Care [N]', 'Named Groups [M]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Prostate Cancer Antigen 3 Score Does Not Predict for Adverse Pathologic Features at Radical Prostatectomy or for Progression-free Survival in Clinically Localized, Intermediate- and High-risk Prostate Cancer. | OBJECTIVE: To evaluate whether preoperative urinary prostate cancer antigen 3 (PCA3) scores predict for adverse pathologic features (APFs) or progression-free survival (PFS) in men with intermediate- or high-risk prostate cancer (PCa) undergoing radical prostatectomy (RP).MATERIALS AND METHODS: One hundred nine men wit... | ['Aged', 'Antigens, Neoplasm', 'Biomarkers, Tumor', 'Biopsy', 'Combined Modality Therapy', 'Disease-Free Survival', 'Follow-Up Studies', 'Humans', 'Incidence', 'Los Angeles', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Neoplasm Grading', 'Neoplasm Recurrence, Local', 'Predictive Value of Tests', 'Prostatectom... | 28,552,819 | [['M01.060.116.100'], ['D23.050.285'], ['D23.101.140'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['E02.186'], ['E01.789.800.190', 'E05.318.740.998.300', 'N04.761.559.590.800.190', 'N05.715.360.575.575.800.190', 'N05.71... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
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