Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Effect of total higher-order aberrations on accommodation in pseudophakic eyes. | PURPOSE: To analyze the effect of total higher-order aberrations (HOAs) on the range of accommodation in pseudophakic eyes and the size of near-vision optotypes.SETTING: Department of Ophthalmology, Nara Medical University, Nara, Japan.METHODS: The study comprised 30 patients (44 eyes) who were diagnosed with cataract ... | ['Accommodation, Ocular', 'Aged', 'Aged, 80 and over', 'Humans', 'Lens Implantation, Intraocular', 'Middle Aged', 'Minimally Invasive Surgical Procedures', 'Phacoemulsification', 'Pseudophakia', 'Refractive Errors', 'Visual Acuity'] | 17,010,861 | [['G14.010'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.540.825.600'], ['M01.060.116.630'], ['E04.502'], ['E04.540.825.249.704', 'E04.943.875'], ['C23.888.681'], ['C11.744'], ['E01.370.380.850.950', 'F02.463.593.932.901', 'G14.940']] | ['Phenomena and Processes [G]', 'Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Pelvic kystic schwannoma evoking a tumor of the right seminal vesicle]. | We present the case of a pelvic schwannoma in a 36 year old man. It was discovered by chance during the medical assessment of a prostatitis. A computed tomography scan and magnetic resonance imaging revealed a 8 centimeters cystic pelvic tumor, closed to the right seminal vesicle. The patient underwent a transrectal ul... | ['Adult', 'Diagnosis, Differential', 'Genital Neoplasms, Male', 'Humans', 'Male', 'Neurilemmoma', 'Pelvic Neoplasms', 'Seminal Vesicles'] | 20,951,936 | [['M01.060.116'], ['E01.171'], ['C04.588.945.440', 'C12.294.260', 'C12.758.409'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.465.625.650.595', 'C04.557.580.600.610.595', 'C04.557.580.625.650.595'], ['C04.588.699'], ['A05.360.444.713']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Impact of traumatic and violent victimization experiences in individuals with schizophrenia and schizoaffective disorder. | Individuals with schizophrenia or schizoaffective disorder (SZ) experience more violent victimization and noninterpersonal traumatic experiences than the general population. Earlier studies, however, have generally excluded one or grouped together victimization and trauma experiences into single outcome variables, whic... | ['Adult', 'Anxiety Disorders', 'Autistic Disorder', 'Cognition Disorders', 'Comorbidity', 'Crime Victims', 'Diagnostic and Statistical Manual of Mental Disorders', 'Female', 'Humans', 'Life Change Events', 'Male', 'Middle Aged', 'Psychiatric Status Rating Scales', 'Psychotic Disorders', 'Risk Factors', 'Schizophrenia',... | 20,921,860 | [['M01.060.116'], ['F03.080'], ['F03.625.164.113.500'], ['F03.615.250'], ['N05.715.350.225', 'N06.850.490.687'], ['M01.135'], ['L01.453.245.945.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.458.410'], ['M01.060.116.630'], ['F04.711.513.653'], ['F03.700.675'], ['E05.318.740.600.800.725', 'N05.715.350... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 0 |
To determine the effect of metoclopramide on gastric emptying in severe head injuries: a prospective, randomized, controlled clinical trial. | To determine the effect of 8-hourly administration of 10 mg intravenous metoclopramide, over a 48-h period on gastric emptying in severe head injury (SHI), 22 patients were prospectively randomized (Glasgow Coma Score of 3-8) to receive 2 ml of intravenous metoclopramide or 2 ml of 5% saline 8-hourly for 48 h. Baseline... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Antiemetics', 'Area Under Curve', 'Craniocerebral Trauma', 'Enteral Nutrition', 'Female', 'Gastric Emptying', 'Humans', 'Injections, Intravenous', 'Male', 'Metoclopramide', 'Middle Aged'] | 12,779,198 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.696.663.050.030', 'D27.505.954.427.095', 'D27.505.954.483.200'], ['E05.318.740.200', 'G03.787.101', 'G07.690.725.064', 'N06.850.520.830.200'], ['C10.900.300', 'C26.915.300'], ['E02.421.360', 'E02.642.500.360'], ['G10.261.360.400'... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Membrane-fusions and cytoplasmic bridges in the cells of the developing cerebellum. | In the developing cerebellum of the neonate rats membrane-fusions and cytoplasmic bridges between cells were observed. These membrane-fusions were characterized by the presence of loops of membrane and cytoplasmic bridges between the two limits of the membrane-fusions. They were found between Purkinje cells, Purkinje c... | ['Animals', 'Animals, Newborn', 'Cell Differentiation', 'Cerebellum', 'Fixatives', 'Intercellular Junctions', 'Microscopy, Electron', 'Purkinje Cells', 'Rats'] | 832,309 | [['B01.050'], ['B01.050.050.282'], ['G04.152'], ['A08.186.211.132.810.428.200'], ['D27.720.355'], ['A11.284.149.165.420'], ['E01.370.350.515.402', 'E05.595.402'], ['A08.186.211.132.810.428.200.212.600', 'A08.675.784', 'A11.671.784'], ['B01.050.150.900.649.313.992.635.505.700']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Studies on interactions between metmyoglobin and heparin. | The complex formation between metmyoglobin and heparin was investigated by absorbance and fluorescence spectroscopy as well as differential scanning microcalorimetry. In acidic pH region, three distinct complexes detected by absorbance measurements are formed depending on pH and time of equilibration. The kinetics of t... | ['Animals', 'Biophysical Phenomena', 'Biophysics', 'Calorimetry, Differential Scanning', 'Heparin', 'Horses', 'Hydrogen-Ion Concentration', 'In Vitro Techniques', 'Macromolecular Substances', 'Metmyoglobin', 'Protein Conformation', 'Protein Denaturation', 'Spectrometry, Fluorescence', 'Spectrophotometry', 'Thermodynami... | 9,785,100 | [['B01.050'], ['G01.154'], ['H01.158.344', 'H01.671.100'], ['E05.196.131.310', 'E05.196.370.310'], ['D09.698.373.400'], ['B01.050.150.900.649.313.984.235.472'], ['G02.300'], ['E05.481'], ['D05'], ['D12.776.422.316.940.500'], ['G02.111.570.820.709'], ['G01.154.651.750.500', 'G02.111.688.750.500'], ['E05.196.712.516.600.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Elevated levels of decidual insulin-like growth factor binding protein-1 in cervical fluid in early and mid-pregnancy are associated with an increased risk of spontaneous preterm delivery. | OBJECTIVE: To study whether elevated levels of decidual insulin-like growth factor binding protein-1 (IGFBP-1) in the cervical fluid of unselected asymptomatic women in early or mid-pregnancy are associated with spontaneous preterm delivery (PTD).DESIGN: Prospective population-based cohort study.SETTING: Maternity Clin... | ['Adolescent', 'Adult', 'Biomarkers', 'Cervix Uteri', 'Decidua', 'Female', 'Humans', 'Insulin-Like Growth Factor Binding Protein 1', 'Middle Aged', 'Obstetric Labor, Premature', 'Pregnancy', 'Pregnancy Trimester, First', 'Pregnancy Trimester, Second', 'Prenatal Diagnosis', 'Prospective Studies', 'Risk Factors', 'Sensit... | 20,374,609 | [['M01.060.057'], ['M01.060.116'], ['D23.101'], ['A05.360.319.679.256'], ['A05.360.319.679.490.373', 'A16.710.289'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.157.420.250'], ['M01.060.116.630'], ['C13.703.420.491'], ['G08.686.784.769'], ['G08.686.707.408'], ['G08.686.707.490'], ['E01.370.378.630'], ['E... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The serine protease HtrA2 cleaves UCH-L1 and inhibits its hydrolase activity: implication in the UCH-L1-mediated cell death. | Ubiquitin (Ub) carboxyl-terminal hydrolase L1 (UCH-L1) has dual functions, such as hydrolase activity on the chemical bonds formed by the C-terminal Gly of Ub and dimerization-dependent ubiquitin ligase activity. Accumulating evidence suggests that dual activities of UCH-L1 were intimately associated with Parkinson's d... | ['Apoptosis', 'Cell Line, Tumor', 'HEK293 Cells', 'High-Temperature Requirement A Serine Peptidase 2', 'Humans', 'Mitochondrial Proteins', 'Proteolysis', 'RNA, Small Interfering', 'Serine Endopeptidases', 'Ubiquitin Thiolesterase'] | 22,001,920 | [['G04.146.954.035'], ['A11.251.210.190', 'A11.251.860.180'], ['A11.251.210.172.750', 'A11.436.334'], ['D08.811.277.656.300.760.431', 'D08.811.277.656.959.350.431', 'D12.644.360.075.429', 'D12.776.476.075.429', 'D12.776.575.656', 'D12.776.637.625'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.575'], ['G0... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Chondrocyte activation by interleukin-1: analysis of the synergistic properties of fibroblast growth factor and phorbol myristate acetate. | Following activation, monolayers of lapine articular chondrocytes secreted into their culture media large amounts of prostaglandin E2 (PGE2) and the neutral metalloproteinases collagenase and gelatinase. Partially purified preparations of synovial "chondrocyte activating factors" (CAF), which contain interleukin-1 (IL-... | ['Animals', 'Calcimycin', 'Cartilage, Articular', 'DNA Probes', 'Dinoprostone', 'Drug Synergism', 'Fibroblast Growth Factors', 'Gelatinases', 'Interleukin-1', 'Metalloendopeptidases', 'Microbial Collagenase', 'Pepsin A', 'Rabbits', 'Signal Transduction', 'Tetradecanoylphorbol Acetate'] | 2,552,926 | [['B01.050'], ['D03.633.100.221.173'], ['A02.165.407.150', 'A02.835.583.192'], ['D13.444.600.223', 'D27.505.259.750.600.223', 'D27.720.470.530.600.223'], ['D10.251.355.255.550.250.200', 'D23.469.050.175.725.250.200'], ['G07.690.773.968.477'], ['D12.644.276.624', 'D12.776.467.624', 'D23.529.624'], ['D08.811.277.656.300.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bottlenose dolphin (Tursiops truncatus) discrimination of harmonic stimuli with range-dependent signal degradation. | The importance of perceived sound source distance has been noted in controlled exposure studies with free-ranging marine mammals. Different behavioral reactions have been observed for sonar exposures with a similar received level but differing source distances. This psychophysical study examined bottlenose dolphins' us... | ['Acoustic Stimulation', 'Animals', 'Behavior, Animal', 'Bottle-Nosed Dolphin', 'Cues', 'Female', 'Hearing', 'Male', 'Motion', 'Pattern Recognition, Physiological', 'Pitch Discrimination', 'Psychoacoustics', 'Sound', 'Vibration'] | 29,960,462 | [['E02.037', 'E02.190.888.030', 'E05.723.136'], ['B01.050'], ['F01.145.113'], ['B01.050.150.900.649.313.875.267.100'], ['F02.463.425.234'], ['F02.830.816.263', 'G07.888.500', 'G11.561.790.263'], ['G01.482'], ['F02.463.593.524'], ['F02.463.593.071.700.408', 'G07.888.125.700.408'], ['E01.370.382.375.060.530', 'E01.370.68... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Socioeconomic and political issues in radiology: a historical analysis. | Radiology literature indexes were searched for articles concerning socioeconomic and political issues published during two 21-year periods: 1920-1940 and 1970-1990. Of 200 articles found, 96 were considered appropriate for study, 40 from 1920-1940 and 56 from 1970-1990. All except two of the articles were from Radiolog... | ['Bibliometrics', 'History, 20th Century', 'Institutional Practice', 'Radiology', 'Socioeconomic Factors', 'State Medicine'] | 1,871,301 | [['L01.178.682.099.325', 'L01.453.183.291'], ['K01.400.504.968'], ['N04.452.758.367'], ['H02.403.740'], ['I01.880.853.996', 'N01.824'], ['N03.349.550.902', 'N03.858']] | ['Information Science [L]', 'Humanities [K]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 |
Spatial But Not Oculomotor Information Biases Perceptual Memory: Evidence From Face Perception and Cognitive Modeling. | Recent research put forward the hypothesis that eye movements are integrated in memory representations and are reactivated when later recalled. However, "looking back to nothing" during recall might be a consequence of spatial memory retrieval. Here, we aimed at distinguishing between the effect of spatial and oculomot... | ['Adolescent', 'Adult', 'Aged', 'Attention', 'Cognition', 'Eye Movements', 'Facial Recognition', 'Female', 'Humans', 'Male', 'Memory', 'Middle Aged', 'Models, Theoretical', 'Photic Stimulation', 'Space Perception', 'Spatial Memory', 'Visual Perception', 'Young Adult'] | 27,859,647 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['F02.830.104.214'], ['F02.463.188'], ['G11.427.410.140', 'G14.350'], ['F02.463.593.524.250.500', 'F02.463.593.524.500.500', 'F02.463.593.932.622.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.425.540'], ['M01.060.116.630'], ['E05.599'], ['E05.7... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Self suppression of phosphoinositide turnover and contraction by stimulating release of endogenous endothelium derived relaxing factor in vascular action of histamine. | STUDY OBJECTIVE: The aim of the study was to examine the relationship between phosphoinositide turnover and vascular contraction in response to histamine, and the role of endothelium derived relaxing factor (EDRF) in these activities.DESIGN: Thoracic aortic strips were studied under isometric tension in an organ bath. ... | ['Animals', 'Calcimycin', 'Calcium', 'Cimetidine', 'Cyclic GMP', 'Diphenhydramine', 'Endothelium, Vascular', 'Histamine', 'In Vitro Techniques', 'Methylene Blue', 'Muscle Contraction', 'Muscle, Smooth, Vascular', 'Nitric Oxide', 'Phosphatidylinositols', 'Rabbits'] | 2,164,882 | [['B01.050'], ['D03.633.100.221.173'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D02.078.370.200', 'D03.383.129.308.130'], ['D03.633.100.759.646.454.160', 'D13.695.462.275', 'D13.695.667.454.160', 'D13.695.827.426.160'], ['D02.092.471.320', 'D02.455.426.559.389.115.250'], ['A07.015.700.500', 'A10.272.491... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Determining early speech development in children with cochlear implants using the ELFRA-2 parental questionnaire. | OBJECTIVES: Increased early identification of hearing loss has led to infants younger than 24 months of age being implanted with cochlear implants. The objective of this study was to assess early speech development in children implanted with a cochlear implant before 24 months of age using the German questionnaire Elte... | ['Age Factors', 'Case-Control Studies', 'Child, Preschool', 'Cochlear Implantation', 'Cochlear Implants', 'Cohort Studies', 'Deafness', 'Female', 'Follow-Up Studies', 'Germany', 'Humans', 'Infant', 'Language Development', 'Male', 'Parents', 'Reference Values', 'Risk Assessment', 'Speech Perception', 'Speech Production ... | 22,465,105 | [['N05.715.350.075', 'N06.850.490.250'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['M01.060.406.448'], ['E04.580.450.220', 'E04.650.220'], ['E07.305.250.319.381.500.500', 'E07.695.150', 'E07.695.202.381.500.500', 'E07.814.458.150'], ['E05.318.372.500.750', 'N05.715.360.330.500.750'... | ['Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Diseases [C]', 'Geographicals [Z]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Differential regulation of adult and embryonic glutamate decarboxylases in rat dentate granule cells after kainate-induced limbic seizures. | In adult brain, the inhibitory GABAergic neurons utilize two distinct molecular forms of the GABA-synthesizing enzyme glutamate decarboxylase (GAD), GAD65 and GAD67. During embryonic development, two truncated forms of GAD67 are also expressed (GAD25 and GAD44), which are translated from two embryonic-specific splice v... | ['Animals', 'Dentate Gyrus', 'Excitatory Amino Acid Agonists', 'Glutamate Decarboxylase', 'Kainic Acid', 'Male', 'RNA, Messenger', 'Rats', 'Rats, Sprague-Dawley', 'Reverse Transcriptase Polymerase Chain Reaction', 'Seizures'] | 11,008,167 | [['B01.050'], ['A08.186.211.180.405.200', 'A08.186.211.200.885.287.500.345.200'], ['D27.505.519.625.190.200', 'D27.505.696.577.190.200'], ['D08.811.520.224.125.250'], ['D03.383.773.400'], ['D13.444.735.544'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.750'], ['E05.393.620.500... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Portable lung ventilators: the potential risk from bacterial colonisation. | Seven portable lung ventilators were investigated to assess the risk of bacterial colonization of the ventilator valve. One valve was deliberately contaminated with Serratia marcescens and the survival of organisms within the valve studied. Periods of colonization by Acinetobacter were found in all the hospital ventila... | ['Acinetobacter', 'Drug Resistance, Microbial', 'Equipment Contamination', 'Sterilization', 'Time Factors', 'Ventilators, Mechanical'] | 3,463,607 | [['B03.440.400.425.537.050', 'B03.660.250.530.050'], ['G06.225', 'G07.690.773.984.269'], ['N06.850.540'], ['N06.850.780.200.450.850'], ['G01.910.857'], ['E07.950']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
LACK OF SYMBIONT ACCOMMODATION controls intracellular symbiont accommodation in root nodule and arbuscular mycorrhizal symbiosis in Lotus japonicus. | Nitrogen-fixing rhizobia and arbuscular mycorrhizal fungi (AMF) form symbioses with plant roots and these are established by precise regulation of symbiont accommodation within host plant cells. In model legumes such as Lotus japonicus and Medicago truncatula, rhizobia enter into roots through an intracellular invasion... | ['Gene Expression Regulation, Plant', 'Lotus', 'Medicago truncatula', 'Mutation', 'Mycorrhizae', 'Plant Proteins', 'Plant Root Nodulation', 'Plant Roots', 'Rhizobium', 'Root Nodules, Plant', 'Symbiosis'] | 30,605,473 | [['G05.308.375'], ['B01.650.940.800.575.912.250.401.565'], ['B01.650.940.800.575.912.250.401.590.750'], ['G05.365.590'], ['A18.400.525', 'A19.690', 'B01.300.655', 'B05.550'], ['D12.776.765'], ['G15.682'], ['A18.400'], ['B03.440.400.425.700.800', 'B03.585.900', 'B03.660.050.662.670'], ['A18.400.875'], ['G06.550.800', 'G... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Binding steps of apolipoprotein A-I with phospholipid monolayers: adsorption and penetration. | In whole HDL particles, the arrangement of apoA-I relative to phospholipids is of crucial interest with respect to the physiological formations of HDL. We report here new data concerning the nature of the interaction of apoA-I with condensed phospholipid (PL) monolayers (phosphatidylcholine and phosphatidylserine). The... | ['Adsorption', 'Apolipoprotein A-I', 'Binding Sites', 'Cholesterol', 'Electrodes', 'Electrolytes', 'Humans', 'Mercury', 'Phosphatidylcholines', 'Phospholipids', 'Polarography', 'Protein Binding'] | 9,819,208 | [['G01.030', 'G02.020'], ['D10.532.091.200.100', 'D12.776.070.400.200.100', 'D12.776.521.120.200.100'], ['G02.111.570.120'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['E07.305.250'], ['D01.248'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.268.556.504', 'D01.268.956.437', 'D... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Demands on professional nursing staff in institutions for dialysis from the view of male and female patients--the results of a survey by means of Critical Incident Technique]. | Contemporary models of competence in nursing are usually based on the questioning of nursing staff and therefore reflect their professional self-image. Our research focuses on the views of male and female patients on the relevant competencies of professional nursing staff. The "Critical Incident Techniqu" (CIT) (Flanag... | ['Attitude of Health Personnel', 'Empathy', 'Female', 'Humans', 'Male', 'Nurse-Patient Relations', 'Nursing Staff', 'Renal Replacement Therapy'] | 15,869,015 | [['F01.100.050', 'N05.300.100'], ['F01.752.355', 'F01.752.543.500.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.401.650.600', 'N05.300.660.560'], ['M01.526.485.680', 'N02.360.680'], ['E02.870']] | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Bladder distension and activation of the efferent function of sensory fibres: similarities with the effect of capsaicin. | 1. The effects of the tachykinin NK2 receptor antagonist MEN 11420 (100 nmol kg(-1), i.v.) and isoprenaline (400 nmol kg(-1), i.v.) were compared in a model of distension-induced bladder activity in isovolumetric conditions. MEN 11420 induced a relaxation of the basal tone of the urinary bladder that was dependent on t... | ['Adrenergic beta-Agonists', 'Animals', 'Capsaicin', 'Cyclooxygenase Inhibitors', 'Drug Interactions', 'Isoproterenol', 'Ketoprofen', 'Male', 'Muscle Contraction', 'Muscle Relaxation', 'Muscle, Smooth', 'Nerve Fibers', 'Neurons, Afferent', 'Peptides, Cyclic', 'Rats', 'Rats, Wistar', 'Receptors, Tachykinin', 'Ruthenium ... | 9,641,541 | [['D27.505.519.625.050.100.200', 'D27.505.696.577.050.100.200'], ['B01.050'], ['D02.065.690.500', 'D02.455.326.271.690.222', 'D02.455.426.559.389.657.166.099', 'D03.132.760.200', 'D10.251.355.325.190'], ['D27.505.519.389.310', 'D27.505.696.663.850.014.040.500.500', 'D27.505.954.158.030.500', 'D27.505.954.329.030.500'],... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Continual neurogenesis of vomeronasal neurons in vitro. | We developed a culture system of vomeronasal neurons in which continuous degeneration and regeneration of axon bundles were observed. Partially dissociated vomeronasal cells from rat embryonic day 15 were grown in culture and formed a miniature vomeronasal-like epithelium. We called these structures vomeronasal pockets... | ['Animals', 'Aphidicolin', 'Axons', 'Cell Division', 'Cells, Cultured', 'Microscopy, Electron', 'Microvilli', 'Nerve Degeneration', 'Nerve Regeneration', 'Olfactory Receptor Neurons', 'Organoids', 'Rats', 'Rats, Sprague-Dawley', 'Vomeronasal Organ'] | 10,413,452 | [['B01.050'], ['D02.455.849.291.075'], ['A08.675.542.145', 'A11.284.180.075', 'A11.671.137', 'A11.671.501.145'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.251'], ['E01.370.350.515.402', 'E05.595.402'], ['A11.284.180.565'], ['C23.550.737'], ['G11.561.585', 'G16.762.611'], ['A04.531.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Neighbourhood environment and transport-related and leisure-time sedentary behaviour amongst women in a city in Southern Brazil: a multilevel analysis. | OBJECTIVES: To assess the association between neighbourhood environmental variables and excessive transport-related and leisure-time sedentary behaviour (ETSB and ELSB, respectively) amongst adult women in Southern Brazil.METHODS: A cross-sectional survey was conducted using a representative sample of 1079 women 20 to ... | ['Adult', 'Aged', 'Brazil', 'Cities', 'Cross-Sectional Studies', 'Environment Design', 'Female', 'Humans', 'Leisure Activities', 'Male', 'Middle Aged', 'Multilevel Analysis', 'Residence Characteristics', 'Sedentary Behavior', 'Surveys and Questionnaires', 'Young Adult'] | 30,888,433 | [['M01.060.116'], ['M01.060.116.100'], ['Z01.107.757.176'], ['G16.500.275.069', 'N06.230.069', 'Z01.433'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['I01.283', 'I01.880.709.359', 'N06.230.145'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I03.450'], ['M01.060.116.630'], ['N0... | ['Named Groups [M]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
The relation of dietary patterns to future survival, health, and cardiovascular events in older adults. | BACKGROUND: There have been few long-term follow-up studies of older adults who follow different dietary patterns.METHODS: We cluster-analyzed data on dietary fat, fiber, protein, carbohydrate, and calorie consumption from the U.S. Cardiovascular Health Study (mean age=73), and examined the relationship of the dietary ... | ['Aged', 'Cardiovascular Diseases', 'Cluster Analysis', 'Diet', 'Energy Intake', 'Female', 'Follow-Up Studies', 'Health Status', 'Humans', 'Incidence', 'Linear Models', 'Male', 'Nutritional Physiological Phenomena', 'Survival Rate'] | 14,680,674 | [['M01.060.116.100'], ['C14'], ['E05.318.740.250', 'N05.715.360.750.200', 'N06.850.520.830.250'], ['G07.203.650.240'], ['G07.203.650.240.340'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['I01.240.425', 'N01.224.425', 'N06.850.505.400.425'], ['B01.050.150.900.649.313.988.... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
The effects of two different low level laser therapies in the treatment of patients with chronic low back pain: A double-blinded randomized clinical trial. | OBJECTIVE: The purpose of this study was to compare the effectiveness of two different laser therapy regimens on pain, lumbar range of motions (ROM) and functional capacity in patients with chronic low back pain (CLBP).METHODS: Forty nine patients with CLBP were randomly assigned into two groups. Group 1 (n= 20) receiv... | ['Adult', 'Aged', 'Chronic Pain', 'Combined Modality Therapy', 'Exercise Therapy', 'Female', 'Hot Temperature', 'Humans', 'Lasers, Gas', 'Lasers, Semiconductor', 'Low Back Pain', 'Low-Level Light Therapy', 'Lumbosacral Region', 'Male', 'Middle Aged', 'Pain Measurement', 'Range of Motion, Articular', 'Surveys and Questi... | 27,472,858 | [['M01.060.116'], ['M01.060.116.100'], ['C23.888.592.612.274'], ['E02.186'], ['E02.760.169.063.500.387', 'E02.779.483', 'E02.831.535.483'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.775.710.380', 'N06.230.300.100.725.232', 'N06.230.300.100.725.710.380'], ['B01.050.150.900.649.313.988.400.112.400.4... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Salicylic acid has a role in regulating gene expression during leaf senescence. | Leaf senescence is a complex process that is controlled by multiple developmental and environmental signals and is manifested by induced expression of a large number of different genes. In this paper we describe experiments that show, for the first time, that the salicylic acid (SA)-signalling pathway has a role in the... | ['Arabidopsis', 'Blotting, Northern', 'Gene Expression Regulation, Plant', 'Mutation', 'Plant Leaves', 'Salicylic Acid', 'Signal Transduction'] | 10,972,893 | [['B01.650.940.800.575.912.250.157.100'], ['E05.196.401.095', 'E05.301.300.074', 'E05.601.100'], ['G05.308.375'], ['G05.365.590'], ['A18.024.812'], ['D02.241.223.100.300.595.608', 'D02.241.511.390.595.608', 'D02.455.426.559.389.127.281.595.608', 'D02.455.426.559.389.657.410.595.608'], ['G02.111.820', 'G04.835']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Behavioral and physiological responses to central administration of corticotropin-releasing factor in the bluebanded goby (Lythrypnus dalli). | Central manipulation of neuromodulators is critical to establishing causal links between brain function and behavioral output. The absence of a rigorous method of evaluating intracerebroventricular (i.c.v.) injection efficacy in small model organisms is one reason why peripheral administration of neuroactive substances... | ['Analysis of Variance', 'Animals', 'Behavior, Animal', 'Corticotropin-Releasing Hormone', 'Fishes', 'Hydrocortisone', 'Injections, Intraventricular', 'Pulmonary Ventilation', 'Time Factors'] | 22,561,750 | [['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['B01.050'], ['F01.145.113'], ['D06.472.699.327.740.140', 'D12.644.400.400.740.140', 'D12.644.548.365.740.140', 'D12.776.631.650.405.740.140'], ['B01.050.150.900.493'], ['D04.210.500.745.745.654.600', 'D06.472.040.585.353.476', 'D06.472.040.585.478.392... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Effectiveness of the typhoid Vi vaccine in overseas travelers from England. | BACKGROUND: Approximately 500 cases of enteric fever, caused by Salmonella enterica serovar Typhi and Paratyphi, are reported in the UK each year. The majority are associated with travel to the Indian subcontinent. The typhoid Vi vaccine protects against S. Typhi and is available to travelers from their general practic... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Case-Control Studies', 'Child', 'Child, Preschool', 'Female', 'Humans', 'Male', 'Middle Aged', 'Travel', 'Treatment Outcome', 'Typhoid Fever', 'Typhoid-Paratyphoid Vaccines', 'United Kingdom', 'Young Adult'] | 25,444,695 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['I03.883'], ['E01.789.800', 'N04.761.559.590.800', ... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Genome sequences of Oceanicola granulosus HTCC2516(T) and Oceanicola batsensis HTCC2597(TDelta). | Genome sequences from the prolific Roseobacter clade in the Alphaproteobacteria are beginning to reveal the genetic basis for the diverse lifestyles of these organisms. Here we present the genome sequences of Oceanicola granulosus HTCC2516(T) and Oceanicola batsensis HTCC2597(T), two marine Roseobacter species isolated... | ['Genome, Bacterial', 'Molecular Sequence Data', 'Rhodobacteraceae'] | 20,418,400 | [['G05.360.340.358.207'], ['L01.453.245.667'], ['B03.660.050.750']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
[Determination of residual organic solvents in flunixin meglumine raw material by headspace gas chromatography]. | A method for the determination of five kinds of residual organic solvents in flunixin meglumine raw material was developed by headspace gas chromatography. An HP-FFAP capillary column (30 m x 0.32 mm x 1.0 microm), a flame ionization detector and the external standard method were used for the separation and quantitativ... | ['2-Propanol', 'Acetates', 'Chromatography, Gas', 'Clonixin', 'Drug Contamination', 'Ethanol', 'Methanol', 'Solvents'] | 22,667,101 | [['D02.033.755.615'], ['D02.241.081.018', 'D10.251.400.045'], ['E05.196.181.349'], ['D03.066.515.375', 'D03.383.725.547.375'], ['N06.850.360'], ['D02.033.375'], ['D02.033.623'], ['D27.720.844']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Combination therapy with mexiletine and sotalol suppresses inherited ventricular arrhythmias in German shepherd dogs better than mexiletine or sotalol monotherapy: a randomized cross-over study. | OBJECTIVES: To determine the spontaneous variability of ventricular arrhythmias (VA) and evaluate anti-arrhythmic efficacy of mexiletine, sotalol, and a mexiletine-sotalol combination in German shepherd dogs (GSD) with inherited arrhythmias.ANIMALS, MATERIALS AND METHODS: 12 affected GSD, median age 20 weeks, received ... | ['Animals', 'Anti-Arrhythmia Agents', 'Arrhythmias, Cardiac', 'Cross-Over Studies', 'Dog Diseases', 'Dogs', 'Drug Therapy, Combination', 'Electrocardiography, Ambulatory', 'Female', 'Male', 'Mexiletine', 'Prospective Studies', 'Sotalol', 'Tachycardia, Ventricular', 'Ventricular Premature Complexes'] | 20,663,731 | [['B01.050'], ['D27.505.954.411.097'], ['C14.280.067', 'C23.550.073'], ['E05.318.370.150', 'N05.715.360.325.150', 'N06.850.520.445.150'], ['C22.268'], ['B01.050.150.900.649.313.750.250.216.200'], ['E02.319.310'], ['E01.370.370.380.240.230', 'E01.370.405.240.230', 'E01.370.520.500.230'], ['D02.092.831.500', 'D02.455.426... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Dual-task effects of simulated lane navigation and story recall in older adults with and without memory impairment. | While driving is a complex task, it becomes relatively automatic over time although unfamiliar situations require increased cognitive effort. Much research has examined driving risk in cognitively impaired elders and found little effect. This study assessed whether mildly memory impaired elders made disproportionate er... | ['Aged', 'Aged, 80 and over', 'Aging', 'Attention', 'Automobile Driving', 'Executive Function', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Memory Disorders', 'Mental Recall', 'Narration', 'Neuropsychological Tests', 'User-Computer Interface'] | 23,043,546 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['G07.345.124'], ['F02.830.104.214'], ['I03.125'], ['F02.463.217'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.597.606.525', 'C23.888.592.604.529', 'F01.700.625'], ['F02.... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Information Science [L]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 0 |
Combination of imatinib and vinorelbine enhances cell growth inhibition in breast cancer cells via PDGFR beta signalling. | INTRODUCTION: Imatinib mesylate is a tyrosine kinase receptor inhibitor targeted against PDGFR alpha and beta, c-kit and bcr-abl. These receptors regulate cellular processes such as proliferation, differentiation, and survival. This study was performed to evaluate the effects of imatinib on breast cancer cell lines wit... | ['Antineoplastic Agents', 'Apoptosis', 'Benzamides', 'Breast Neoplasms', 'Cell Line, Tumor', 'Cell Proliferation', 'Drug Therapy, Combination', 'Female', 'Humans', 'Imatinib Mesylate', 'Immunoblotting', 'Immunohistochemistry', 'Oncogene Protein v-akt', 'Phosphorylation', 'Piperazines', 'Pyrimidines', 'Receptor, Platele... | 18,809,244 | [['D27.505.954.248'], ['G04.146.954.035'], ['D02.065.277', 'D02.241.223.100.100', 'D02.455.426.559.389.127.085'], ['C04.588.180', 'C17.800.090.500'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.161.750', 'G07.345.249.410.750'], ['E02.319.310'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.065.277.456', 'D02... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Intracisternal granules in the somatotrophs in the anterior pituitary of the mouse. | A detailed study of the anterior pituitaries of pregnant and lactating mice revealed changes occurring in the ultrastructure of the somatotrophs. The rough endoplasmic reticulum cisternae become greatly dilated forming channels that are continuous with the perivascular space. This occurrence expands the membrane surfac... | ['Animals', 'Cytoplasmic Granules', 'Female', 'Growth Hormone', 'Lactation', 'Mice', 'Mice, Inbred C57BL', 'Microscopy, Electron', 'Pituitary Gland, Anterior', 'Pregnancy', 'Pregnancy, Animal', 'Weaning'] | 3,590,152 | [['B01.050'], ['A11.284.430.214.190.500', 'A11.284.430.214.190.875.190.190'], ['D06.472.699.631.525.425', 'D12.644.548.691.525.425'], ['G08.686.523', 'G08.686.702.500'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420'], ['E01.370.350.515.402... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Genome-wide scan reveals population stratification and footprints of recent selection in Nelore cattle. | BACKGROUND: This study aimed at (1) assessing the genomic stratification of experimental lines of Nelore cattle that have experienced different selection regimes for growth traits, and (2) identifying genomic regions that have undergone recent selection. We used a sample of 763 animals genotyped with the Illumina Bovin... | ['Animals', 'Breeding', 'Cattle', 'DNA Fingerprinting', 'Energy Metabolism', 'Female', 'Genotype', 'Growth', 'Haplotypes', 'Male', 'Phenotype', 'Polymorphism, Single Nucleotide', 'Quantitative Trait Loci', 'Selection, Genetic', 'Whole Genome Sequencing'] | 29,720,080 | [['B01.050'], ['E05.820.150', 'G05.090'], ['B01.050.150.900.649.313.500.380.271'], ['E05.318.740.225.500.500', 'E05.393.290', 'I01.198.780.937.375', 'N04.452.910.099.750'], ['G03.295'], ['G05.380'], ['G07.345.249'], ['G05.380.360'], ['G05.695'], ['G05.365.795.598'], ['G05.360.340.024.380.937'], ['G05.783'], ['E05.393.7... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
[Biological factor of work conditions in medical institutions and its influence on health status of medical personnel]. | The article covers epidemiologic analysis of medical staff health state, epidemiologic evaluation of biologic factor's influence (degree and character of) on clinical staff, detection of principal risk factors for being infected. The aim is to create a supervision system and to elaborate effective measures for occupati... | ['Adolescent', 'Adult', 'Bacterial Infections', 'Candidiasis', 'Health Personnel', 'Humans', 'Middle Aged', 'Occupational Diseases', 'Occupational Health', 'Risk Factors'] | 9,662,936 | [['M01.060.057'], ['M01.060.116'], ['C01.150.252'], ['C01.150.703.160'], ['M01.526.485', 'N02.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C24'], ['N01.400.525'], ['E05.318.740.600.800.725', 'N05.715.350.200.700', 'N05.715.360.750.625.700.700', 'N06.850.490.625.750', 'N06.850.520.830.6... | ['Named Groups [M]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A study of some mitochondrial and peroxisomal enzymes in human colonic adenocarcinoma. | Three mitochondrial enzymes, cytochrome oxidase, succinate dehydrogenase, and monoamine oxidase, and two peroxisomal enzymes, catalase and urate oxidase, were measured spectrophotometrically in the postnuclear supernatant prepared from homogenates of normal mucosa and carcinoma of the human colon. The specific activiti... | ['Adenocarcinoma', 'Catalase', 'Colonic Neoplasms', 'Electron Transport Complex IV', 'Humans', 'Intestinal Mucosa', 'Microbodies', 'Mitochondria', 'Monoamine Oxidase', 'Succinate Dehydrogenase', 'Urate Oxidase'] | 6,256,583 | [['C04.557.470.200.025'], ['D08.811.682.732.332'], ['C04.588.274.476.411.307.180', 'C06.301.371.411.307.180', 'C06.405.249.411.307.180', 'C06.405.469.158.356.180', 'C06.405.469.491.307.180'], ['D05.500.562.374', 'D08.811.600.250.687', 'D08.811.682.285', 'D12.776.157.530.450.250.875.304', 'D12.776.543.277.687', 'D12.776... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Reproductive history and stage of breast cancer. | A woman's reproductive history influences her risk of breast cancer. The authors hypothesized that reproductive history also influences stage of disease at the time of diagnosis. The authors analyzed a population-based cohort of 1.5 million Danish women born between 1935 and 1978 for whom individual information on birt... | ['Adult', 'Age Factors', 'Aged', 'Breast Neoplasms', 'Cohort Studies', 'Disease Progression', 'Female', 'Humans', 'Middle Aged', 'Neoplasm Staging', 'Prognosis', 'Reproductive History', 'Risk Assessment'] | 10,604,775 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['C04.588.180', 'C17.800.090.500'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['C23.550.291.656'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.789.625'], ['E01.789'], ['E01... | ['Named Groups [M]', 'Health Care [N]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Seed storage protein deficiency improves sulfur amino acid content in common bean (Phaseolus vulgaris L.): redirection of sulfur from gamma-glutamyl-S-methyl-cysteine. | The contents of sulfur amino acids in seeds of common bean ( Phaseolus vulgaris L.) are suboptimal for nutrition. They accumulate large amounts of a gamma-glutamyl dipeptide of S-methyl-cysteine, a nonprotein amino acid that cannot substitute for methionine or cysteine in the diet. Protein accumulation and amino acid c... | ['Amino Acids', 'Amino Acids, Sulfur', 'Cysteine', 'Dipeptides', 'Nutritive Value', 'Phaseolus', 'Plant Proteins', 'Seeds', 'Sulfur'] | 18,588,315 | [['D12.125'], ['D02.886.030', 'D12.125.166'], ['D02.886.030.230', 'D02.886.489.155', 'D12.125.154.299', 'D12.125.166.230'], ['D12.644.456.345'], ['G07.203.650.660', 'J01.576.423.850.730.750', 'N06.850.601.750'], ['B01.650.940.800.575.912.250.401.649'], ['D12.776.765'], ['A18.024.500.750', 'G07.203.300.775', 'J02.500.77... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Biosynthesis of elastin and other matrix-macromolecules in veinous arterial prosthesis. | Homologous saphenous veins where implanted in the arterial circilation (femoral artery) of dogs for various times (1 to 9 months, most data given for 3 months). After this period, the in vitro biosynthesis of intercullar matrix macromolecules was studied by incubating the veins in organ culture conditions in the presen... | ['Animals', 'Arteries', 'Blood Circulation', 'Blood Vessel Prosthesis', 'Collagen', 'Desmosine', 'Dogs', 'Elastin', 'Female', 'Femoral Artery', 'Glycoproteins', 'Graft Survival', 'Hexosamines', 'Hydroxyproline', 'Lysine', 'Macromolecular Substances', 'Male', 'Organ Culture Techniques', 'Proteoglycans', 'Saphenous Vein'... | 796,809 | [['B01.050'], ['A07.015.114'], ['G09.330.100'], ['E07.695.110'], ['D05.750.078.280', 'D12.776.860.300.250'], ['D03.383.725.762.300', 'D12.125.072.200'], ['B01.050.150.900.649.313.750.250.216.200'], ['D05.750.078.421', 'D12.776.860.300.350'], ['A07.015.114.351'], ['D09.400.430', 'D12.776.395'], ['G12.875.545.340'], ['D0... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitotic phosphorylation of DNA topoisomerase II alpha by protein kinase CK2 creates the MPM-2 phosphoepitope on Ser-1469. | DNA topoisomerase II alpha is required for chromatin condensation during prophase. This process is temporally linked with the appearance of mitosis-specific phosphorylation sites on topoisomerase IIalpha including one recognized by the MPM-2 monoclonal antibody. We now report that the ability of mitotic extracts to cre... | ['Amino Acid Sequence', 'Animals', 'Antigens, Neoplasm', 'Casein Kinase II', 'Catalysis', 'Cell Cycle Proteins', 'Cell Extracts', 'Chromosomes, Human', 'DNA Topoisomerases, Type II', 'DNA-Binding Proteins', 'Guanosine Triphosphate', 'HeLa Cells', 'Heparin', 'Humans', 'Isoenzymes', 'Kinesin', 'Mitosis', 'Molecular Seque... | 10,942,766 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D23.050.285'], ['D08.811.913.696.620.682.700.140.600', 'D12.776.476.150.600'], ['G02.130'], ['D12.776.167'], ['D20.777.162'], ['A11.284.187.520.300', 'G05.360.162.520.300'], ['D08.811.399.403.741'], ['D12.776.260'], ['D03.633.100.759.646.454.504', 'D13.695.667... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Combined blockade of ADP receptors and PI3-kinase p110â fully prevents platelet and leukocyte activation during hypothermic extracorporeal circulation. | Extracorporeal circulation (ECC) and hypothermia are used to maintain stable circulatory parameters and improve the ischemia tolerance of patients in cardiac surgery. However, ECC and hypothermia induce activation mechanisms in platelets and leukocytes, which are mediated by the platelet agonist ADP and the phosphoinos... | ['Adenosine Diphosphate', 'Analysis of Variance', 'Cardiac Surgical Procedures', 'Class I Phosphatidylinositol 3-Kinases', 'Enzyme-Linked Immunosorbent Assay', 'Extracorporeal Circulation', 'Flow Cytometry', 'Humans', 'Hypothermia, Induced', 'In Vitro Techniques', 'Leukocytes', 'Models, Biological', 'Morpholines', 'P-S... | 22,701,645 | [['D03.633.100.759.646.138.124', 'D13.695.667.138.124', 'D13.695.827.068.124'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['E04.100.376', 'E04.928.220'], ['D08.811.913.696.620.500.100.100', 'D08.811.913.696.620.500.200.100', 'D12.776.476.162'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E0... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Favourable mid-term outcome after heart transplantation for late Fontan failure. | OBJECTIVES: Fontan failure (FF) represents a growing and challenging indication for paediatric orthotopic heart transplantation (OHT). The aim of this study was to identify predictors of the best mid-term outcome in OHT after FF.METHODS: Twenty-year multi-institutional retrospective analysis on OHT for FF.RESULTS: Betw... | ['Adolescent', 'Child', 'Child, Preschool', 'Female', 'Fontan Procedure', 'Heart Defects, Congenital', 'Heart Failure', 'Heart Transplantation', 'Humans', 'Infant', 'Kaplan-Meier Estimate', 'Male', 'Retrospective Studies', 'Treatment Outcome'] | 25,035,415 | [['M01.060.057'], ['M01.060.406'], ['M01.060.406.448'], ['E04.035.410.295', 'E04.100.376.410.295', 'E04.100.376.724.500', 'E04.100.814.868.875.295', 'E04.928.220.370.295', 'E04.928.220.560.500'], ['C14.240.400', 'C14.280.400', 'C16.131.240.400'], ['C14.280.434'], ['E04.100.376.475', 'E04.928.220.390', 'E04.936.450.475'... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Calcium-regulating hormones across the menstrual cycle: evidence of a secondary hyperparathyroidism in women with PMS. | Calcium metabolism across one menstrual cycle was studied in 12 healthy, premenopausal women. Seven women had documented premenstrual syndrome (PMS), and five were asymptomatic controls. Fasting blood samples were drawn at six points throughout the ovulatory cycle. In both the asymptomatic and the PMS groups, total and... | ['Calcifediol', 'Calcitriol', 'Calcium', 'Cohort Studies', 'Estradiol', 'Female', 'Humans', 'Hyperparathyroidism', 'Luteinizing Hormone', 'Menstrual Cycle', 'Multivariate Analysis', 'Parathyroid Hormone', 'Premenopause', 'Premenstrual Syndrome', 'Reference Values'] | 7,608,284 | [['D04.210.500.247.222.159.478.250', 'D04.210.500.247.808.146.478.250', 'D04.210.500.812.768.196.478.250', 'D10.570.938.146.478.250'], ['D04.210.500.247.222.159.478.387.300', 'D04.210.500.247.808.146.478.387.300', 'D04.210.500.812.768.196.478.387.300', 'D10.570.938.146.478.387.300'], ['D01.268.552.100', 'D01.552.539.28... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Expression of the green fluorescent protein in Paramecium tetraurelia. | In this paper we describe the expression of green fluorescent protein (GFP) as a reporter in vivo to monitor transformation in Paramecium cells. This is not trivial because of the limited number of strong promoters available for heterologous expression and the very high AT content of the genomic DNA, the consequence of... | ['Animals', 'Gene Expression', 'Gene Transfer Techniques', 'Genes, Reporter', 'Green Fluorescent Proteins', 'Luminescent Proteins', 'Paramecium tetraurelia', 'Promoter Regions, Genetic'] | 10,727,022 | [['B01.050'], ['G05.297'], ['E05.393.350'], ['G05.360.340.024.340.435'], ['D12.776.532.265'], ['D12.776.532'], ['B01.043.185.650.375.550.637.700'], ['G02.111.570.080.689.675', 'G05.360.080.689.675', 'G05.360.340.024.340.137.750.680']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Outcomes of idiopathic chronic large pericardial effusion. | OBJECTIVE: Aim of this paper is to evaluate the outcomes of 'idiopathic' chronic large pericardial effusions without initial evidence of pericarditis.METHODS: All consecutive cases of idiopathic chronic large pericardial effusions evaluated from 2000 to 2015 in three Italian tertiary referral centres for pericardial di... | ['Aged', 'Asymptomatic Diseases', 'Cardiac Tamponade', 'Echocardiography', 'Female', 'Follow-Up Studies', 'Humans', 'Italy', 'Male', 'Middle Aged', 'Pericardial Effusion', 'Pericardiectomy', 'Pericardiocentesis', 'Pericarditis', 'Prospective Studies', 'Recurrence', 'Risk Factors', 'Severity of Illness Index', 'Survival... | 30,274,986 | [['M01.060.116.100'], ['C23.550.291.187'], ['C14.280.155'], ['E01.370.350.130.750', 'E01.370.350.850.220', 'E01.370.370.380.220'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.542.489'], ['M01.060.116.630'], ['C14.280.6... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Multi-channel audio-based estimation of the Pre-Ejection Period. | Systolic time intervals (STI) have significant diagnostic and prognostic value to assess the global cardiac function. Presently, STIs are regarded as a promising tool for long-term follow-up of patients with chronic cardiovascular diseases. Heart sound has proven to be a valuable approach for STI estimation, in particu... | ['Algorithms', 'Auscultation', 'Echocardiography', 'Heart Sounds', 'Humans', 'Signal Processing, Computer-Assisted', 'Systole'] | 26,737,642 | [['G17.035', 'L01.224.050'], ['E01.370.600.060'], ['E01.370.350.130.750', 'E01.370.350.850.220', 'E01.370.370.380.220'], ['G09.330.380.510'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.800'], ['G09.330.580.880', 'G11.427.494.570.880']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
[Mechanism of platelet aggregation and mode of action of platelet antiaggregants]. | Platelets play an important role in arterial thrombosis. Following the adhesion of platelets to an injured vascular wall, platelet activation occurs, involving calcium fluxes, phosphoinositol metabolism, protein phosphorylation, arachidonate cascade. This leads to the formation of the fibrinogen membrane receptor, the ... | ['Arachidonic Acids', 'Aspirin', 'Blood Vessels', 'Cyclic AMP', 'Humans', 'Platelet Adhesiveness', 'Platelet Aggregation', 'Platelet Aggregation Inhibitors'] | 2,556,779 | [['D10.251.355.255.100', 'D10.251.355.310.166'], ['D02.455.426.559.389.657.410.595.176'], ['A07.015'], ['D03.633.100.759.646.138.395', 'D13.695.462.200', 'D13.695.667.138.395', 'D13.695.827.068.395'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G09.188.390.600.500', 'G09.188.670'], ['G09.188.370.687', 'G09.188.3... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Identification of a surface for binding to the GDNF-GFR alpha 1 complex in the first cadherin-like domain of RET. | The RET receptor tyrosine kinase is activated by binding to a ligand complex formed by a member of the glial cell line-derived neurotrophic factor (GDNF) family of neurotrophic factors bound to its cognate GDNF-family receptor-alpha (GFR alpha) glycosylphosphatidylinositol-linked co-receptor. Molecular modeling studies... | ['Amino Acid Sequence', 'Animals', 'CHO Cells', 'Cadherins', 'Carbohydrates', 'Cell Line', 'Cricetinae', 'Cross-Linking Reagents', 'Cysteine', 'DNA', 'Dose-Response Relationship, Drug', 'Glial Cell Line-Derived Neurotrophic Factor', 'Glial Cell Line-Derived Neurotrophic Factor Receptors', 'Glycosylation', 'Glycosylphos... | 14,514,671 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['A11.251.210.200', 'A11.436.155'], ['D12.776.395.550.200.200', 'D12.776.543.550.200.200', 'D23.050.301.350.200'], ['D09'], ['A11.251.210'], ['B01.050.150.900.649.313.992.635.075.250'], ['D27.720.470.410.210'], ['D02.886.030.230', 'D02.886.489.155', 'D12.125.154... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Ten-year follow-up of an anatomical hydroxyapatite-coated total hip prosthesis. | We report our results after ten year follow-up of 107 consecutive ABG-I hip prostheses implanted between June 1990 and December 1992: Only 84 prostheses were still in the study after ten years, but only six patients had undergone surgical revision. We can consider our clinical outcomes as excellent, with a whole-implan... | ['Coated Materials, Biocompatible', 'Durapatite', 'Equipment Failure Analysis', 'Female', 'Follow-Up Studies', 'Hip Prosthesis', 'Humans', 'Male', 'Middle Aged', 'Prosthesis Design', 'Prosthesis Failure', 'Reoperation', 'Survival Rate', 'Zirconium'] | 16,506,026 | [['D25.130.420', 'J01.637.051.130.420'], ['D01.029.260.700.675.374.075.025.300.150', 'D01.146.360.050.300.200', 'D01.578.122.477.300', 'D01.695.625.675.650.075.025.300.150'], ['E05.325.192'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['E07.695.400.400'], ['B01.050.150.90... | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Changes in meibomian fatty acids and clinical signs in patients with meibomian gland dysfunction after minocycline treatment. | AIMS: To assess the changes in ocular surface abnormalities and meibomian fatty acid composition in patients suffering from meibomian gland dysfunction (MGD) after treatment with oral minocycline associated with lid hygiene versus lid hygiene only.METHODS: We evaluated the break-up time, corneal staining and quality of... | ['Administration, Oral', 'Aged', 'Aged, 80 and over', 'Analysis of Variance', 'Anti-Bacterial Agents', 'Blepharitis', 'Eyelid Diseases', 'Fatty Acids', 'Female', 'Humans', 'Hygiene', 'Male', 'Meibomian Glands', 'Middle Aged', 'Minocycline', 'Tears', 'Treatment Outcome'] | 18,511,542 | [['E02.319.267.100'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['D27.505.954.122.085'], ['C11.338.133'], ['C11.338'], ['D10.251'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.547', 'N06.850.670'], ['A09.371.337.614', 'A10.336.827.600'], ... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The contribution of changes in milk delivery to the prolongation of lactational infertility induced by food restriction or increased litter size. | In rats, the length of lactational anovulation is prolonged when litter size is increased or when the dam is food restricted. In both of these situations the energetic demand on the dam is increased, milk delivery to each pup is reduced, and consequently, patterns of pup suckling may be changed. We investigated the con... | ['Animals', 'Body Weight', 'Diestrus', 'Eating', 'Energy Metabolism', 'Female', 'Fertility', 'Food Deprivation', 'Lactation', 'Litter Size', 'Mammary Glands, Animal', 'Rats', 'Rats, Wistar'] | 10,073,472 | [['B01.050'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['G08.686.195.374'], ['G07.203.650.283', 'G10.261.330'], ['G03.295'], ['G08.686.210'], ['F01.658.433'], ['G08.686.523', 'G08.686.702.500'], ['G08.686.530', 'G08.686.784.769.498.300'], ['A10... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Electrophoretic profiles of proteins and glycoproteins of chick embryo fibroblasts during development]. | The variations of proteins and glycoproteins of Chick embryo fibroblasts are studied during development. This investigation is carried out using polyacrylamide disc gel electrophoresis in SDS. Two glycoproteins of high apparent molecular weight (250,000 and 200,000) undergo quantitative modification: they increase from... | ['Animals', 'Chick Embryo', 'Electrophoresis, Polyacrylamide Gel', 'Fibroblasts', 'Glycoproteins', 'Proteins', 'Time Factors'] | 111,822 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Development of partial ontogenic resistance to powdery mildew in hop cones and its management implications. | Knowledge of processes leading to crop damage is central to devising rational approaches to disease management. Multiple experiments established that infection of hop cones by Podosphaera macularis was most severe if inoculation occurred within 15 to 21 days after bloom. This period of infection was associated with the... | ['Ascomycota', 'Crops, Agricultural', 'Disease Resistance', 'Fungicides, Industrial', 'Phenotype', 'Plant Diseases', 'Plant Leaves'] | 25,811,173 | [['B01.300.107'], ['B01.650.160', 'G07.203.300.300', 'J02.500.300'], ['C23.550.291.671', 'G12.450.564.250', 'G12.450.800.250', 'G15.630.250'], ['D27.720.031.700.288', 'D27.888.723.288'], ['G05.695'], ['G15.610'], ['A18.024.812']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Near-ultraviolet circular dichroism of bovine high molecular weight alpha-crystallin. | High molecular weight (HMW) alpha-crystallin isolated from cow nucleus has a molecular weight greater than 5 x 10(6) Daltons. Its particle dimensions have been reported to be over 500 nm. It is derived mainly from low molecular weight (LMW) alpha-crystallin. The conformational change as LMW alpha-crystallin is converte... | ['Absorption', 'Animals', 'Cattle', 'Circular Dichroism', 'Crystallins', 'Electrophoresis, Polyacrylamide Gel', 'Molecular Weight', 'Spectrum Analysis', 'Ultraviolet Rays'] | 2,777,524 | [['G01.015', 'G02.010', 'G03.015', 'G03.787.024', 'G07.690.725.015'], ['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['E05.196.867.151'], ['D12.776.306.366'], ['E05.196.401.402', 'E05.301.300.319'], ['G02.494'], ['E05.196.867'], ['G01.358.500.505.650.891', 'G01.590.540.891', 'G01.750.250.650.891', 'G01.750.750.6... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Statistical modeling for Bayesian extrapolation of adult clinical trial information in pediatric drug evaluation. | Children represent a large underserved population of "therapeutic orphans," as an estimated 80% of children are treated off-label. However, pediatric drug development often faces substantial challenges, including economic, logistical, technical, and ethical barriers, among others. Among many efforts trying to remove th... | ['Adult', 'Bayes Theorem', 'Clinical Trials as Topic', 'Colitis, Ulcerative', 'Drug Evaluation', 'Humans', 'Models, Statistical', 'Research Design'] | 28,448,684 | [['M01.060.116'], ['E05.318.740.600.200', 'N05.715.360.750.625.150', 'N06.850.520.830.600.200'], ['E05.318.372.250.250', 'N05.715.360.330.250.250', 'N06.850.520.450.250.250'], ['C06.405.205.265.231', 'C06.405.205.731.249', 'C06.405.469.158.188.231', 'C06.405.469.432.249'], ['E05.290.625', 'E05.337.425'], ['B01.050.150.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Biochemical and hematological reference intervals for Krefft's turtles Emydura macquarii krefftii from the Burnett River Catchment, Australia. | Biochemical and hematological reference intervals have not previously been reported for Emydura macquarii krefftii. In 2009, 56 E. m. krefftii were captured by hand from the Burnett Catchment, clinically assessed to determine health status and blood sampled. Reference intervals were calculated from the 35 clinically he... | ['Animals', 'Australia', 'Blood Chemical Analysis', 'Female', 'Male', 'Reference Values', 'Rivers', 'Turtles'] | 21,797,034 | [['B01.050'], ['Z01.639.100', 'Z01.678.100.373'], ['E01.370.225.124.100', 'E05.200.124.100'], ['E05.978.810'], ['G01.311.750', 'G16.500.275.280.650', 'N06.230.232.650'], ['B01.050.150.900.833.848']] | ['Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Use of sodium trimetaphosphate in the inhibition of dentin matrix metalloproteinases and as a remineralizing agent. | OBJECTIVES: Because of its ability to act as an antiproteolytic agent, the effect of sodium trimetaphosphate (STMP) against specific enzymes extracted from sound dentin and its performance under acidic challenge on demineralized dentin were investigated.METHODS: The antiproteolytic potential of STMP (0.5%, 1.0%, and 1.... | ['Adolescent', 'Adult', 'Analysis of Variance', 'Animals', 'Brazil', 'Calcium Hydroxide', 'Cattle', 'Dentin', 'Hardness', 'Humans', 'Hydrogen-Ion Concentration', 'In Vitro Techniques', 'Matrix Metalloproteinase 2', 'Matrix Metalloproteinase 9', 'Matrix Metalloproteinase Inhibitors', 'Matrix Metalloproteinases', 'Polyph... | 29,079,452 | [['M01.060.057'], ['M01.060.116'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['B01.050'], ['Z01.107.757.176'], ['D01.045.250.313', 'D01.146.335', 'D01.248.497.158.459.150'], ['B01.050.150.900.649.313.500.380.271'], ['A14.549.167.900.280'], ['G01.374.647'], ['B01.050.150.900.649.313.988.400.112.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
Survival of breast cancer patients according to changes in expression of selected markers between primary tumor and lymph node metastases. | BACKGROUND: The differences between primary and metastatic tumor cells might be important for treatment selection and prognostication.MATERIALS & METHODS: Expression of ER, PR, HER2, CK5/6, EGFR, Ki-67, Ep-CAM, P-cadherin, CD24, CD44, ALDH was assessed immunohistochemically in primary tumor (T) and corresponding synchr... | ['Adult', 'Aged', 'Aged, 80 and over', 'Biomarkers, Tumor', 'Breast Neoplasms', 'Female', 'Humans', 'Lymphatic Metastasis', 'Middle Aged', 'Neoplasm Proteins', 'Proportional Hazards Models', 'Sentinel Lymph Node', 'Survival Analysis'] | 26,860,337 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D23.101.140'], ['C04.588.180', 'C17.800.090.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.697.650.560', 'C23.550.727.650.560'], ['M01.060.116.630'], ['D12.776.624'], ['E05.318.740.500.700', 'E05.318.740.600.700', 'E05.318.740.750.725', 'E... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Cerebrovascular mortality in Spain]. | INTRODUCTION: Although the mortality due to cerebrovascular disease in Spain has been considerably reduced in the past twenty years, at all ages and in both sexes, it is still the second cause of death in men and first in women.OBJECTIVE: To describe the mortality due to cerebrovascular disease in Spain.MATERIAL AND ME... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Cerebrovascular Disorders', 'Child', 'Child, Preschool', 'Female', 'Humans', 'Infant', 'Male', 'Middle Aged', 'Spain'] | 10,696,666 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C10.228.140.300', 'C14.907.253'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.116.630'], ['Z01.542.846']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
Racial/Ethnic and Socioeconomic Disparities in Hydration Status Among US Adults and the Role of Tap Water and Other Beverage Intake. | OBJECTIVES: To evaluate whether differences in tap water and other beverage intake explain differences in inadequate hydration among US adults by race/ethnicity and income.METHODS: We estimated the prevalence of inadequate hydration (urine osmolality ? 800 mOsm/kg) by race/ethnicity and income of 8258 participants aged... | ['Adult', 'Beverages', 'Continental Population Groups', 'Drinking', 'Ethnic Groups', 'Female', 'Humans', 'Male', 'Middle Aged', 'Nutrition Surveys', 'Socioeconomic Factors'] | 28,727,528 | [['M01.060.116'], ['G07.203.100', 'J02.200'], ['M01.686.508'], ['G07.203.650.283.249', 'G10.261.330.249'], ['M01.686.754', 'N01.224.317'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.308.980.485', 'N05.715.360.300.800.469', 'N06.850.505.616', 'N06.850.520.308.980.469'], ['I01.880.853... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 |
Fragment-based lead discovery: screening and optimizing fragments for thermolysin inhibition. | Fragment-based drug discovery has gained a foothold in today's lead identification processes. We present the application of in silico fragment-based screening for the discovery of novel lead compounds for the metalloendoproteinase thermolysin. We have chosen thermolysin to validate our screening approach as it is a wel... | ['Aspirin', 'Binding Sites', 'Computer Simulation', 'Crystallography, X-Ray', 'Databases, Protein', 'Drug Design', 'Protease Inhibitors', 'Protein Structure, Tertiary', 'Software', 'Thermolysin'] | 20,394,106 | [['D02.455.426.559.389.657.410.595.176'], ['G02.111.570.120'], ['L01.224.160'], ['E05.196.309.742.225'], ['L01.313.500.750.300.188.400.300.750', 'L01.313.500.750.300.188.400.325.710', 'L01.470.750.750.300.750', 'L01.470.750.750.325.710'], ['E05.290.500', 'H01.158.703.007.338.500', 'H01.181.466.338.500'], ['D27.505.519.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Effectiveness of Population Health Management Using the Propeller Health Asthma Platform: A Randomized Clinical Trial. | BACKGROUND: Telehealth strategies for asthma have focused primarily on adherence to controller medications. Telemonitoring of short-acting â-agonist (SABA) focuses on patterns of use and may allow more timely action to avert exacerbations. Studies assessing this approach are lacking.OBJECTIVE: This pragmatic controlled... | ['Adrenergic beta-Agonists', 'Adult', 'Anti-Asthmatic Agents', 'Asthma', 'Child', 'Drug Utilization', 'Female', 'Humans', 'Male', 'Metered Dose Inhalers', 'Telemedicine'] | 26,778,246 | [['D27.505.519.625.050.100.200', 'D27.505.696.577.050.100.200'], ['M01.060.116'], ['D27.505.954.796.050'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['M01.060.406'], ['N04.452.706.477'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E07.605.750'], ['H02.403.840', 'L01.178.847.652', ... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Information Science [L]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 |
Retrograde non trans-septal balloon mitral valvotomy in mitral stenosis with interrupted inferior vena cava, left superior vena cava, and hugely dilated coronary sinus. | A 22-year-old woman with severe mitral stenosis was referred to us for further evaluation and management. She was found to have severe mitral stenosis, severe tricuspid regurgitation with dilated right atrium and right ventricle with persistent left superior vena cava and hugely dilated coronary sinus. Valve was suitab... | ['Balloon Valvuloplasty', 'Cardiac Catheterization', 'Coronary Sinus', 'Dilatation, Pathologic', 'Echocardiography, Doppler, Color', 'Echocardiography, Transesophageal', 'Female', 'Hemodynamics', 'Humans', 'Mitral Valve Stenosis', 'Severity of Illness Index', 'Treatment Outcome', 'Tricuspid Valve Insufficiency', 'Vascu... | 26,032,663 | [['E02.148.108', 'E05.157.125'], ['E01.370.370.380.140', 'E02.148.442', 'E05.157.250'], ['A07.015.908.194.500'], ['C23.300.325'], ['E01.370.350.130.750.220.220', 'E01.370.350.850.220.220.220', 'E01.370.350.850.850.220.220', 'E01.370.350.850.850.850.850.220', 'E01.370.370.380.220.220.220'], ['E01.370.350.130.750.235', '... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]', 'Named Groups [M]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The Dutch Cannabis Dependence (CanDep) study on the course of frequent cannabis use and dependence: objectives, methods and sample characteristics. | This paper presents an overview of the prospective cohort design of the Dutch Cannabis Dependence (CanDep) study, which investigates (i) the three-year natural course of frequent cannabis use (? three days per week in the past 12 months) and cannabis dependence; and (ii) the factors involved in the transition from freq... | ['Adolescent', 'Adult', 'Age of Onset', 'Cohort Studies', 'Diagnosis, Computer-Assisted', 'Disease Progression', 'Female', 'Humans', 'Interview, Psychological', 'Male', 'Marijuana Abuse', 'Netherlands', 'Outcome Assessment, Health Care', 'Predictive Value of Tests', 'Retrospective Studies', 'Risk Factors', 'Time Factor... | 21,815,231 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075.100', 'N06.850.490.250.100'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E01.158', 'L01.313.500.750.100.158'], ['C23.550.291.656'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F04.669.599'], ['C25.775.635', 'F03.900.635'],... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 1 |
Co-occurrence of hemiscrotal agenesis with cutis marmorata telangiectatica congenita and hydronephrosis affecting the same side of the body. | To our knowledge, there are nine previous reports of patients with congenital scrotal agenesis (CSA), seven of which were bilateral, and unilateral in two, also named as hemiscrotal agenesis (HSA). Here, we report a male infant with the previously undescribed co-occurrence of HSA with cutis marmorata telangiectatica co... | ['Humans', 'Hydronephrosis', 'Infant, Newborn', 'Male', 'Phenotype', 'Scrotum', 'Skin Diseases, Vascular', 'Syndrome', 'Telangiectasis'] | 24,243,754 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.777.419.307', 'C13.351.968.419.307'], ['M01.060.703.520'], ['G05.695'], ['A05.360.444.661'], ['C17.800.862'], ['C23.550.288.500'], ['C14.907.823']] | ['Organisms [B]', 'Diseases [C]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Numerical studies of biocontrol efficacies of foliar plant pathogens in relation to the characteristics of a biocontrol agent. | A previously published generic mathematic model has been used in a numerical study to understand the dynamics of foliar pathogens in relation to mechanisms, and timing and coverage of biocontrol agent (BCA) applications. With the model parameter values used, it was demonstrated that a BCA possessing either competition ... | ['Antibiosis', 'Models, Biological', 'Plant Diseases'] | 20,626,285 | [['G06.550.050', 'G16.062'], ['E05.599.395'], ['G15.610']] | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Variation in haematological parameters among inbred strains of rat. | Haematological determinations were carried out on 7 inbred strains of rats using a standardized procedure. Significant genetic variation was found for many of the parameters although none of the strains had values which could be termed pathological. Measurements also varied significantly from day to day. Factorial anal... | ['Analysis of Variance', 'Animals', 'Animals, Laboratory', 'Blood Cell Count', 'Erythrocyte Indices', 'Hematocrit', 'Hemoglobins', 'Male', 'Rats', 'Rats, Inbred Strains', 'Species Specificity'] | 7,289,575 | [['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['B01.050'], ['B01.050.050.199'], ['E01.370.225.500.195.107', 'E01.370.225.625.107', 'E05.200.500.195.107', 'E05.200.625.107', 'E05.242.195.107', 'G04.140.107', 'G09.188.105'], ['E01.370.225.625.230', 'E05.200.625.230', 'G09.188.260'], ['E01.370.225.62... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Discovery of Potential Biomarkers with Dose- and Time-Dependence in Cisplatin-Induced Nephrotoxicity Using Metabolomics Integrated with a Principal Component-Based Area Calculation Strategy. | Cisplatin is a potent chemotherapeutic agent. However, its clinical usage is restricted by serious adverse effects, especially nephrotoxicity. For revealing the dose- and time-dependence of cisplatin-induced nephrotoxicity, mass spectrometry-based metabolomics integrated with a principal component-based area calculatio... | ['Animals', 'Antineoplastic Agents', 'Area Under Curve', 'Biomarkers', 'Chromatography, Gas', 'Chromatography, Liquid', 'Cisplatin', 'Kidney', 'Male', 'Mass Spectrometry', 'Metabolomics', 'Principal Component Analysis', 'Rats', 'Rats, Sprague-Dawley'] | 27,030,963 | [['B01.050'], ['D27.505.954.248'], ['E05.318.740.200', 'G03.787.101', 'G07.690.725.064', 'N06.850.520.830.200'], ['D23.101'], ['E05.196.181.349'], ['E05.196.181.400'], ['D01.210.375', 'D01.625.125', 'D01.710.100'], ['A05.810.453'], ['E05.196.566'], ['H01.158.201.586', 'H01.158.273.180.599', 'H01.181.122.638'], ['E05.31... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anatomy [A]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Multiple local minima in radiotherapy optimization problems with dose-volume constraints. | The cause of multiple local minima in beam weight optimization problems subject to dose-volume constraints is analyzed. Three objective functions were considered: (a) maximization of tumor control probability (TCP), (b) maximization of the minimum target dose, and (c) minimization of the mean-squared-deviation of the t... | ['Algorithms', 'Humans', 'Models, Theoretical', 'Radiotherapy Dosage', 'Radiotherapy Planning, Computer-Assisted'] | 9,243,478 | [['G17.035', 'L01.224.050'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599'], ['E02.815.639'], ['E02.950.825', 'L01.313.500.750.100.710.600.608']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
QSAR model for predicting cell viability of human embryonic kidney cells exposed to SiO₂ nanoparticles. | A predictive model for the viability (%) of cultured human embryonic kidney cells (HEK293) exposed to 20 and 50 nm silica nanoparticles was built using 'optimal descriptors' as mathematical functions of size, concentration and exposure time. The calculation was carried out with CORAL software (http://www.insilico.eu/co... | ['Calibration', 'Cell Survival', 'Cytotoxins', 'HEK293 Cells', 'Humans', 'Nanoparticles', 'Quantitative Structure-Activity Relationship', 'Silicon Dioxide', 'Software'] | 26,439,516 | [['E05.978.155'], ['G04.346'], ['D27.888.569.213'], ['A11.251.210.172.750', 'A11.436.334'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['J01.637.512.600'], ['G02.111.830.500', 'G07.690.773.997.500'], ['D01.578.750', 'D01.650.550.825', 'D01.837.725'], ['L01.224.900']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
[Treating Moderately Severe Acute Pancreatitis with Raw Rhubarbs by Intranasal Jejuna Injection: a Randomized Clinical Analysis]. | Objective To observe clinical efficacy of raw rhubarbs (by intranasal jejuna injection) for moderately severe acute pancreatitis (MSAP) , and its effects on gastrointestinal tract and coagulation fibrinolysis. Methods Totally 84 MSAP patients were randomly assigned to the control group and the treatment group by random... | ['Administration, Intranasal', 'Blood Coagulation', 'Blood Coagulation Tests', 'Humans', 'Pancreatitis', 'Partial Thromboplastin Time', 'Phytotherapy', 'Prothrombin Time', 'Rheum'] | 30,650,480 | [['E02.319.267.120.655.500'], ['G09.188.390.150'], ['E01.370.225.625.115', 'E05.200.625.115'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C06.689.750'], ['E01.370.225.625.115.600', 'E05.200.625.115.600', 'G09.188.660'], ['E02.190.755'], ['E01.370.225.625.115.610', 'E05.200.625.115.610', 'G09.188.680'], ['B01.65... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Quantifying the Holocaust: Hyperintense kill rates during the Nazi genocide. | Operation Reinhard (1942-1943) was the largest single murder campaign of the Holocaust, during which some 1.7 million Jews from German-occupied Poland were murdered by the Nazis. Most perished in gas chambers at the death camps Belzec, Sobibor, and Treblinka. However, the tempo, kill rates, and spatial dynamics of thes... | ['Concentration Camps', 'Crime Victims', 'History, 20th Century', 'Holocaust', 'Homicide', 'Humans', 'Jews', 'National Socialism', 'Poland', 'Warfare', 'World War II'] | 30,613,773 | [['I01.880.604.787.358', 'J03.200'], ['M01.135'], ['K01.400.504.968'], ['I01.198.240.903.149.500', 'I01.880.735.950.500.903.149.500'], ['I01.198.240.470', 'I01.880.735.344'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.686.754.600'], ['I01.696.586'], ['Z01.542.248.679'], ['I01.880.735.950.500'], ['I01.880.73... | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Technology, Industry, and Agriculture [J]', 'Named Groups [M]', 'Humanities [K]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 1 |
Physical stability of drugs after storage above and below the glass transition temperature: Relationship to glass-forming ability. | Amorphous materials are inherently unstable and tend to crystallize upon storage. In this study, we investigated the extent to which the physical stability and inherent crystallization tendency of drugs are related to their glass-forming ability (GFA), the glass transition temperature (Tg) and thermodynamic factors. Di... | ['Calorimetry, Differential Scanning', 'Crystallization', 'Drug Stability', 'Glass', 'Structure-Activity Relationship', 'Support Vector Machine', 'Temperature', 'Thermodynamics', 'Transition Temperature'] | 26,341,321 | [['E05.196.131.310', 'E05.196.370.310'], ['E05.196.300', 'G02.171'], ['E05.916.330'], ['J01.637.437'], ['G02.111.830', 'G07.690.773.997'], ['G17.035.250.500.500.500', 'L01.224.050.375.530.500.500'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.150.450', 'N06.230.300.100.725.710'], ['G01.90... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]', 'Health Care [N]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 |
Modulation of human lymphocyte proliferation by salivary gland extracts of ixodid ticks (Acari: Ixodidae): effect of feeding stage and sex. | Ixodid ticks remain attached to their hosts for several days to weeks. During this extended feeding process new proteins involved in the modulation of host immune responses are expressed in tick salivary glands. In our study a stimulatory or inhibitory effect of salivary gland extracts (SGE) of unfed and partially fed ... | ['Animals', 'Feeding Behavior', 'Female', 'Humans', 'Ixodidae', 'Lymphocyte Activation', 'Male', 'Salivary Glands', 'Sex Characteristics', 'Species Specificity', 'Tissue Extracts'] | 14,971,600 | [['B01.050'], ['F01.145.113.547', 'F01.145.407', 'G07.203.650.353'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.500.131.166.132.832.400'], ['E01.370.225.812.482', 'E05.200.812.482', 'E05.478.594.530', 'G12.450.050.400.545', 'G12.565'], ['A03.556.500.760', 'A10.336.779', 'A14.549.760'], ['G08.686.815'], ... | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Inactivation of a Pleurotus ostreatus versatile peroxidase-encoding gene (mnp2) results in reduced lignin degradation. | Lignin biodegradation by white-rot fungi is pivotal to the earth's carbon cycle. Manganese peroxidases (MnPs), the most common extracellular ligninolytic peroxidases produced by white-rot fungi, are considered key in ligninolysis. Pleurotus ostreatus, the oyster mushroom, is a preferential lignin degrader occupying nic... | ['Amino Acid Sequence', 'Fungal Proteins', 'Gene Silencing', 'Lignin', 'Molecular Sequence Data', 'Peroxidases', 'Pleurotus', 'Wood'] | 24,119,015 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D12.776.354'], ['G05.308.203.374'], ['D05.750.078.562.180.515', 'D05.750.078.687', 'D20.538', 'D25.720.099.687', 'J01.637.051.720.099.687'], ['L01.453.245.667'], ['D08.811.682.732'], ['B01.300.179.100.650'], ['A18.450.500.500', 'J01.637.241.900']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Rapid molecular identification of Neisseria meningitidis isolates using the polymerase chain reaction followed by single-stranded conformation polymorphism analysis. | Typing of Neisseria meningitidis strains is currently performed with conventional and molecular methods. Our objectives were: first, to develop a polymerase chain reaction (PCR) followed by single-stranded conformation polymorphism (SSCP) analysis of the PorA gene (VR1 region) to distinguish N. meningitidis subtypes an... | ['Bacterial Typing Techniques', 'Base Sequence', 'Child', 'DNA, Bacterial', 'Disease Outbreaks', 'Genes, Bacterial', 'Greece', 'Humans', 'Meningococcal Infections', 'Molecular Epidemiology', 'Neisseria meningitidis', 'Phenotype', 'Polymerase Chain Reaction', 'Polymorphism, Single-Stranded Conformational', 'Porins', 'Se... | 16,051,066 | [['E01.370.225.875.150.125', 'E05.200.875.150.125'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['M01.060.406'], ['D13.444.308.212'], ['N06.850.290'], ['G05.360.340.024.340.364.249', 'G05.360.340.358.024.249', 'G05.360.340.358.207.249'], ['Z01.542.383'], ['B01.050.150.900.649.313.988.400.112.400.400'], ... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Geographicals [Z]', 'Organisms [B]', 'Diseases [C]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 1 |
Secular trends in incidence of type 1 and type 2 diabetes in Hong Kong: A retrospective cohort study. | BACKGROUND: There is very limited data on the time trend of diabetes incidence in Asia. Using population-level data, we report the secular trend of the incidence of type 1 and type 2 diabetes in Hong Kong between 2002 and 2015.METHODS AND FINDINGS: The Hong Kong Diabetes Surveillance Database hosts clinical information... | ['Adolescent', 'Adult', 'Age Distribution', 'Aged', 'Aged, 80 and over', 'Child', 'Child, Preschool', 'Cohort Studies', 'Diabetes Mellitus, Type 1', 'Diabetes Mellitus, Type 2', 'Female', 'Hong Kong', 'Humans', 'Incidence', 'Infant', 'Infant, Newborn', 'Male', 'Middle Aged', 'Population Growth', 'Regression Analysis', ... | 32,078,650 | [['M01.060.057'], ['M01.060.116'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['M01.060.406'], ['M01.060.406.448'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['C18.452.394.750.124', 'C19.246.267', 'C20.111.327'], ['C18.452.39... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Geographicals [Z]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Cutaneous malignant melanoma in females: the role of hormonal and reproductive factors. | The role of hormonal and reproductive factors as risks for cutaneous malignant melanoma (CMM) was explored by means of a population-based case-control study conducted in Turin, north-western Italy, on 186 female CMM cases and 205 controls. Past use of oral contraceptives (OC) did not seem to exert any effect on CMM ris... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Case-Control Studies', 'Contraceptives, Oral', 'Female', 'Hormones', 'Humans', 'Maternal Age', 'Melanoma', 'Middle Aged', 'Parity', 'Random Allocation', 'Reproduction', 'Risk Factors', 'Skin Neoplasms'] | 2,262,243 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['D27.505.696.875.360.276.210', 'D27.505.954.705.360.276.210'], ['D06.472', 'D27.505.696.399.472'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G08.686.5... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Housing histories of assertive community treatment clients: program impacts and factors associated with residential stability. | OBJECTIVE: Although housing is widely recognized as a crucial issue for people with severe and persistent mental illness, there is much to learn about the ongoing housing experiences of this group of people. Using secondary data, this study examined the housing histories of 65 assertive community treatment (ACT) client... | ['Age Factors', 'Community Mental Health Services', 'Female', 'Housing', 'Humans', 'Income', 'Independent Living', 'Longevity', 'Male', 'Multivariate Analysis', 'Program Evaluation', 'Sex Factors', 'Substance-Related Disorders', 'Survival Analysis'] | 20,370,965 | [['N05.715.350.075', 'N06.850.490.250'], ['F04.408.307', 'N02.421.143.183', 'N02.421.461.232'], ['J03.340', 'N01.224.791.400', 'N06.230.150.360', 'N06.850.505.400.800.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N01.824.417'], ['I03.050.500', 'N01.224.791.550', 'N06.850.505.400.800.550'], ['G07.345.124.519... | ['Health Care [N]', 'Psychiatry and Psychology [F]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 |
Differential prediction of maladjustment scores with the Snyder Hope subscales. | The present study examined the relation between two Synder Hope subscales (Agency: goal motivation; Pathways: goal planning) and adjustment problems (a composite of seven MMPI-2 clinical scales). Each of 354 university students completed both the Hope Scale and the MMPI-2. Whereas scores on Hope, Agency, and Pathways s... | ['Adjustment Disorders', 'Adult', 'Female', 'Humans', 'Internal-External Control', 'MMPI', 'Male', 'Motivation', 'Personality Inventory', 'Psychometrics', 'Reproducibility of Results'] | 9,923,183 | [['F03.950.500'], ['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.379'], ['F04.711.647.513.607'], ['F01.658', 'F01.752.543.500.750'], ['F04.711.647.513'], ['F04.711.780'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725']] | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The peroxisome deficient Arabidopsis mutant sse1 exhibits impaired fatty acid synthesis. | The Arabidopsis Shrunken Seed 1 (SSE1) gene encodes a homolog of the peroxisome biogenesis factor Pex16p, and a loss-of-function mutation in this gene alters seed storage composition. Two lines of evidence support a function for SSE1 in peroxisome biogenesis: the peroxisomal localization of a green fluorescent protein-... | ['Arabidopsis', 'Arabidopsis Proteins', 'Endoplasmic Reticulum', 'Fatty Acids', 'Gene Expression Regulation, Developmental', 'Gene Expression Regulation, Plant', 'Green Fluorescent Proteins', 'Luminescent Proteins', 'Microscopy, Electron', 'Mutation', 'Peroxins', 'Peroxisomes', 'Plant Oils', 'Recombinant Fusion Protein... | 15,173,561 | [['B01.650.940.800.575.912.250.157.100'], ['D12.776.765.149'], ['A11.284.430.214.190.875.248'], ['D10.251'], ['G05.308.310'], ['G05.308.375'], ['D12.776.532.265'], ['D12.776.532'], ['E01.370.350.515.402', 'E05.595.402'], ['G05.365.590'], ['D12.776.157.635'], ['A11.284.430.214.190.500.585.600', 'A11.284.430.214.190.875.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Eight-Year Experience With 3-T Intraoperative MRI Integration in Focal Pediatric Epilepsy Surgery: Impact on Extent of Resection, Residual Volumes, and Seizure Outcomes. | OBJECTIVE. The purpose of this study was to investigate the influence of 3-T intraoperative MRI (ioMRI) on the extent of resection of pediatric focal epileptogenic lesions, residual lesion volumes, and postoperative seizure outcomes. MATERIALS AND METHODS. All surgical procedures for focal epilepsy from 2003 to 2017 we... | ['Child', 'Child, Preschool', 'Contrast Media', 'Epilepsies, Partial', 'Female', 'Humans', 'Imaging, Three-Dimensional', 'Intraoperative Care', 'Magnetic Resonance Imaging', 'Male', 'Retrospective Studies'] | 32,208,007 | [['M01.060.406'], ['M01.060.406.448'], ['D27.505.259.500', 'D27.720.259'], ['C10.228.140.490.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.400', 'L01.224.308.410'], ['E02.760.731.400', 'E04.604.249', 'N02.421.585.722.400'], ['E01.370.350.825.500'], ['E05.318.372.500.500.500', 'E05.318.372.500.75... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Focal or diffuse lesions in persistent hyperinsulinemic hypoglycemia of infancy: concerns about interpretation of intraoperative frozen sections. | Persistent hyperinsulinemic hypoglycemia of infancy (PHHI) results from defects of regulated insulin release from pancreatic beta cells and is often refractory to medical treatment. Histological changes in the pancreas associated with PHHI may be focal or diffuse, and the intraoperative confirmation and siting of focal... | ['Cell Division', 'Cell Nucleus', 'Child', 'Child, Preschool', 'Frozen Sections', 'Humans', 'Hyperinsulinism', 'Hypoglycemia', 'Infant', 'Infant, Newborn', 'Intraoperative Period', 'Islets of Langerhans', 'Observer Variation', 'Pancreatic Diseases', 'Random Allocation', 'Reproducibility of Results', 'Single-Blind Metho... | 11,178,629 | [['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['M01.060.406'], ['M01.060.406.448'], ['E01.370.225.500.620.530.160.260', 'E01.370.225.750.600.530.160.260', 'E05.200.500.620.530.160.260', 'E05.200.750.600.530.160.260'], ['B01.050.150.900.649... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Enhancement of osteoblastic differentiation in alginate gel beads with bioactive octacalcium phosphate particles. | The present study investigated whether alginate (Alg) hydrogel microbeads have a role in maintaining mouse bone marrow stromal ST-2 cells and release the cells after being stimulated by synthetic octacalcium phosphate (OCP), which is a mineral crystal capable of stimulating osteoblastic differentiation during a convers... | ['Alginates', 'Animals', 'Bone Substitutes', 'Calcium Phosphates', 'Cell Differentiation', 'Cell Line', 'Gels', 'Glucuronic Acid', 'Hexuronic Acids', 'Mesenchymal Stem Cells', 'Mice', 'Microspheres', 'Osteoblasts', 'Osteogenesis', 'Tissue Scaffolds'] | 26,657,659 | [['D09.698.068'], ['B01.050'], ['D25.130.325', 'J01.637.051.130.325'], ['D01.029.260.700.675.374.075', 'D01.146.360', 'D01.695.625.675.650.075'], ['G04.152'], ['A11.251.210'], ['D20.280.320', 'D26.255.165.320'], ['D02.241.081.844.915.162.249', 'D02.241.152.811.162.500', 'D02.241.511.902.915.162.500', 'D09.811.922.162.5... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Over Expression of NANOS3 and DAZL in Human Embryonic Stem Cells. | The mechanisms underlying human germ cell development are largely unknown, partly due to the scarcity of primordial germ cells and the inaccessibility of the human germline to genetic analysis. Human embryonic stem cells can differentiate to germ cells in vitro and can be genetically modified to study the genetic requi... | ['Cell Differentiation', 'Embryonic Stem Cells', 'Female', 'Gene Expression', 'Germ Cells', 'Heterografts', 'Humans', 'Male', 'RNA, Messenger', 'RNA-Binding Proteins', 'Transcription, Genetic'] | 27,768,780 | [['G04.152'], ['A11.872.700.250'], ['G05.297'], ['A05.360.490', 'A11.497'], ['A01.941.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D13.444.735.544'], ['D12.776.157.725', 'D12.776.664.962'], ['G02.111.873', 'G05.297.700']] | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Fear and aggressiveness in the speech of female anxiety neurotics]. | With Gottschalk's and Gleser's technique for quantitative verbal content analysis it has been shown that in general females suffering from anxiety neurosis (N = 30) frequently verbalize their anxiety, even though they are not in an acute state of anxiety. There is, however, no significant increase in the expression of ... | ['Adult', 'Aggression', 'Anxiety Disorders', 'Fear', 'Female', 'Guilt', 'Hostility', 'Humans', 'Psychoanalytic Interpretation', 'Psychoanalytic Therapy', 'Verbal Behavior'] | 7,234,148 | [['M01.060.116'], ['F01.145.126.125', 'F01.145.813.045'], ['F03.080'], ['F01.470.361'], ['F01.470.483'], ['F01.470.596'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F04.628'], ['F04.754.709'], ['F01.145.209.908']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Three-dimensional characterization of regional lung deformation. | The deformation of the lung during inspiration and expiration involves regional variations in volume change and orientational preferences. Studies have reported techniques for measuring the displacement field in the lung based on imaging or image registration. However, means of interpreting all the information in the d... | ['Biomechanical Phenomena', 'Exhalation', 'Finite Element Analysis', 'Humans', 'Imaging, Three-Dimensional', 'Inhalation', 'Lung', 'Radiography', 'Respiration'] | 21,802,086 | [['G01.154.090', 'G01.374.089'], ['G09.772.705.700.275'], ['E05.355'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.400', 'L01.224.308.410'], ['G09.772.705.700.390'], ['A04.411'], ['E01.370.350.700'], ['G09.772.705']] | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Information Science [L]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Elevated blood lead levels in children of construction workers. | OBJECTIVES: This study examined whether children of lead-exposed construction workers had higher blood lead levels than neighborhood control children.METHODS: Twenty-nine construction workers were identified from the New Jersey Adult Blood Lead Epidemiology and Surveillance (ABLES) registry. Eighteen control families w... | ['Adult', 'Child', 'Child, Preschool', 'Dust', 'Erythrocytes', 'Humans', 'Infant', 'Interviews as Topic', 'Lead', 'Lead Poisoning', 'New Jersey', 'Occupational Exposure', 'Paint', 'Protoporphyrins', 'Risk Factors', 'Water Supply'] | 9,279,275 | [['M01.060.116'], ['M01.060.406'], ['M01.060.406.448'], ['D20.633.222'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['E05.318.308.420', 'L01.399.250.520', 'N05.715.360.300.400', 'N06.850.520.308.420'], ['D01.268.556.435', 'D01.552.544.435'], ['C2... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]', 'Diseases [C]', 'Geographicals [Z]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 1 |
Effects of caffeine, halothane, and 4-chloro-m-cresol on skeletal muscle lactate and pyruvate in malignant hyperthermia-susceptible and normal swine as assessed by microdialysis. | BACKGROUND: Skeletal muscle fibers from malignant hyperthermia (MH)-susceptible humans and swine are markedly more sensitive to ryanodine receptor (RyR1) agonists than those from normal individuals. Reproducible shifts in the dose-response of skeletal muscle to caffeine and halothane are the basis of the current in vit... | ['Anesthesia, General', 'Anesthetics, Dissociative', 'Anesthetics, Inhalation', 'Anesthetics, Intravenous', 'Animals', 'Blood Gas Analysis', 'Caffeine', 'Central Nervous System Stimulants', 'Creatine Kinase', 'Cresols', 'Dose-Response Relationship, Drug', 'Electrolytes', 'Glucose', 'Halothane', 'Ketamine', 'Lactic Acid... | 16,394,695 | [['E03.155.197'], ['D27.505.696.277.100.035.075.035', 'D27.505.954.427.210.100.035.075.035'], ['D27.505.696.277.100.035.060', 'D27.505.954.427.210.100.035.060'], ['D27.505.696.277.100.035.075', 'D27.505.954.427.210.100.035.075'], ['B01.050'], ['E01.370.225.124.100.100', 'E01.370.386.700.100', 'E05.200.124.100.100'], ['... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of antimycin and 2-deoxyglucose on adenine nucleotides in human platelets. Role of metabolic adenosine triphosphate in primary aggregation, secondary aggregation and shape change of platetets. | 1. Human platelet-rich plasma prelabelled with [(3)H]adenine was incubated at 37 degrees C with antimycin A and 2-deoxy-d-glucose. Variations in the amounts of ATP, ADP and P(i), and in the radioactivity of ATP, ADP, AMP, IMP, hypoxanthine+inosine and adenine were determined during incubation. Adrenaline- and ADP-induc... | ['Adenine', 'Adenosine Diphosphate', 'Adenosine Monophosphate', 'Adenosine Triphosphate', 'Antimycin A', 'Blood Platelets', 'Deoxy Sugars', 'Deoxyglucose', 'Humans', 'Hypoxanthines', 'In Vitro Techniques', 'Inosine Nucleotides', 'Phosphates', 'Platelet Aggregation', 'Tritium'] | 4,462,589 | [['D03.633.100.759.138'], ['D03.633.100.759.646.138.124', 'D13.695.667.138.124', 'D13.695.827.068.124'], ['D03.633.100.759.646.138.180', 'D13.695.667.138.180', 'D13.695.827.068.180'], ['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['D02.540.576.500.750'], ['A11.118.188', 'A15.145.229.188... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Aplexone targets the HMG-CoA reductase pathway and differentially regulates arteriovenous angiogenesis. | Arterial and venous endothelial cells exhibit distinct molecular characteristics at early developmental stages. These lineage-specific molecular programs are instructive to the development of distinct vascular architectures and physiological conditions of arteries and veins, but their roles in angiogenesis remain unexp... | ['Angiogenesis Inhibitors', 'Animals', 'Animals, Genetically Modified', 'Arteries', 'Cells, Cultured', 'Drug Delivery Systems', 'Drug Evaluation, Preclinical', 'Embryo, Nonmammalian', 'Humans', 'Hydroxymethylglutaryl CoA Reductases', 'Hydroxymethylglutaryl-CoA Reductase Inhibitors', 'Molecular Targeted Therapy', 'Neova... | 21,307,094 | [['D27.505.696.377.077.099', 'D27.505.696.377.450.100', 'D27.505.954.248.025'], ['B01.050'], ['B01.050.050.136', 'B05.620.136'], ['A07.015.114'], ['A11.251'], ['E02.319.300'], ['E05.290.750', 'E05.337.550'], ['A13.350', 'A16.331'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.682.047.820.150.415'], ['D27.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The development and testing of a new communication tool to help clinicians inform patients with obstructive sleep apnoea syndrome about treatment options. | The objective of this study was to develop a tool to help clinicians inform patients about mechanical treatment options, continuous positive airway pressure and oral appliances for obstructive sleep apnoea syndrome, and to assess its validity, reliability and acceptability. Continuous positive airway pressure is always... | ['Communication', 'Continuous Positive Airway Pressure', 'Decision Making', 'Female', 'Humans', 'Male', 'Middle Aged', 'Patient Education as Topic', 'Patient Satisfaction', 'Physician-Patient Relations', 'Reproducibility of Results', 'Sleep Apnea, Obstructive', 'Time Factors'] | 22,463,694 | [['F01.145.209', 'L01.143'], ['E02.041.625.790.259', 'E02.880.820.790.259'], ['F02.463.785.373'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['I02.233.332.500', 'N02.421.726.407.680'], ['F01.100.150.750.625', 'F01.145.488.887.625', 'N04.452.822.700', 'N05.300.150.800.625', 'N05.715.360.600'],... | ['Psychiatry and Psychology [F]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 0 |
Connecting mutations of the RNA polymerase II C-terminal domain to complex phenotypic changes using combined gene expression and network analyses. | The C-terminal domain (CTD) of the largest subunit in DNA-dependent RNA polymerase II (RNAP II) is essential for mRNA synthesis and processing, through coordination of an astounding array of protein-protein interactions. Not surprisingly, CTD mutations can have complex, pleiotropic impacts on phenotype. For example, in... | ['Amino Acid Sequence', 'Cell Separation', 'Chromosomes, Fungal', 'DNA, Fungal', 'Flow Cytometry', 'Gene Expression', 'Molecular Sequence Data', 'Mutation', 'Oligonucleotide Array Sequence Analysis', 'RNA Polymerase II', 'Saccharomyces cerevisiae'] | 20,613,981 | [['G02.111.570.060', 'L01.453.245.667.060'], ['E01.370.225.500.363', 'E05.200.500.363', 'E05.242.363'], ['A11.284.187.360', 'A19.311', 'G05.360.162.360'], ['D13.444.308.300'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.200.500.386.350', 'E05.242.363... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Visually interpretable deep network for diagnosis of breast masses on mammograms. | Recently, deep learning technology has achieved various successes in medical image analysis studies including computer-aided diagnosis (CADx). However, current CADx approaches based on deep learning have a limitation in interpreting diagnostic decisions. The limited interpretability is a major challenge for practical u... | ['Breast', 'Breast Neoplasms', 'Female', 'Humans', 'Mammography', 'Radiographic Image Interpretation, Computer-Assisted'] | 30,511,660 | [['A01.236'], ['C04.588.180', 'C17.800.090.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.700.500'], ['E01.158.600.680', 'E01.370.350.350.700', 'E01.370.350.700.705', 'L01.313.500.750.100.158.600.680']] | ['Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Sirolimus for the treatment of juvenile nasopharyngeal angiofibroma. | Juvenile nasopharyngeal angiofibroma (JNA) is a pathologically benign yet locally aggressive and destructive tumor that develops in the choana and nasopharynx. Historical treatment of JNA has included embolization, surgical resection, and radiation. Here, we describe three patients who received therapy with the mTOR in... | ['Adolescent', 'Angiofibroma', 'Antibiotics, Antineoplastic', 'Child', 'Humans', 'Male', 'Nasopharyngeal Neoplasms', 'Sirolimus', 'Treatment Outcome'] | 31,925,925 | [['M01.060.057'], ['C04.557.645.100'], ['D27.505.954.248.106'], ['M01.060.406'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.443.665.710.650', 'C07.550.350.650', 'C07.550.745.650', 'C09.647.710.650', 'C09.775.350.650', 'C09.775.549.650'], ['D02.540.505.760'], ['E01.789.800', 'N04.761.559.590.800', 'N05.7... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Specificity of the bacteriophage lambda N gene product (pN): nut sequences are necessary and sufficient for antitermination by pN. | We have cloned the nutR site together with the tR1 site of bacteriophage lambda in the E. coli galactose operon to examine whether the lambda promoter sequences PR and PL are involved in the recognition specificity of the lambda N gene product (pN). We first constructed a derivative of plasmid pBR322 in which the expre... | ['Bacteriophage lambda', 'Drug Resistance, Microbial', 'Escherichia coli', 'Galactose', 'Genes, Viral', 'Operon', 'Plasmids', 'Tetracycline', 'Transcription, Genetic', 'Viral Proteins'] | 160,286 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Multi-scale analysis of the toraymyxin adsorption cartridge. Part I: molecular interaction of polymyxin B with endotoxins. | Endotoxins or lipopolysaccharides are the main constituents of the outer leaflet of Gram-negative bacteria membrane and play a central role in the pathogenesis of the septic shock. Polymyxin B has both antibacterial and antiendotoxin capability; indeed it is able to destroy the bacterial outer membrane and bind endotox... | ['Anti-Bacterial Agents', 'Endotoxins', 'Humans', 'Lipopolysaccharides', 'Models, Molecular', 'Molecular Structure', 'Polymyxin B'] | 16,552,671 | [['D27.505.954.122.085'], ['D23.946.123.329'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D09.400.500', 'D09.698.718.450', 'D10.494', 'D23.050.161.616.525', 'D23.946.123.329.500'], ['E05.599.595'], ['G02.111.570', 'G02.466'], ['D04.345.566.780.750', 'D10.477.750.750', 'D12.644.050.600.750', 'D12.644.641.780.750... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Long non‑coding RNA ferritin heavy polypeptide 1 pseudogene 3 controls glioma cell proliferation and apoptosis via regulation of the microRNA‑224‑5p/tumor protein D52 axis. | The aim of the present study was to investigate the potential role and regulatory mechanism of long non‑coding RNA ferritin heavy polypeptide 1 pseudogene 3 (FTH1P3) in glioma development. The expression of FTH1P3 in low‑ and high‑grade glioma tissues was investigated using reverse transcription‑quantitative polymerase... | ['Adult', 'Apoptosis', 'Biomarkers', 'Cell Line, Tumor', 'Cell Proliferation', 'Female', 'Flow Cytometry', 'Gene Expression Regulation, Neoplastic', 'Genes, Reporter', 'Glioma', 'Humans', 'Male', 'MicroRNAs', 'Neoplasm Proteins', 'RNA Interference', 'RNA, Long Noncoding', 'Young Adult'] | 30,221,720 | [['M01.060.116'], ['G04.146.954.035'], ['D23.101'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.161.750', 'G07.345.249.410.750'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.200.500.386.350', 'E05.242.363.342', 'E05.242.386.350'], ['G05.308.370'], ... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
An assessment of the awareness of local anesthetic systemic toxicity among multi-specialty postgraduate residents. | Local anesthetics (LAs) are extensively used in clinical practice by both anesthesiologists and non-anesthesiologists and are often associated with systemic toxicity. We hypothesize that this awareness is inadequate among medical specialists and entails a risk of misdiagnosis and underreporting of such events. We there... | ['Anesthesia, Local', 'Anesthesiology', 'Anesthetics, Local', 'Cross-Sectional Studies', 'Health Knowledge, Attitudes, Practice', 'Heart Diseases', 'Humans', 'Internship and Residency', 'Neurotoxicity Syndromes', 'Surveys and Questionnaires'] | 25,138,822 | [['E03.155.086.231'], ['H02.403.066'], ['D27.505.696.277.100.200', 'D27.505.696.663.850.025', 'D27.505.954.427.210.100.200'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['F01.100.150.500', 'N05.300.150.410'], ['C14.280'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I02.358.337... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 |
Modulation of cyclobutane thymine photodimer formation in T11-tracts in rotationally phased nucleosome core particles and DNA minicircles. | Cyclobutane pyrimidine dimers (CPDs) are DNA photoproducts linked to skin cancer, whose mutagenicity depends in part on their frequency of formation and deamination. Nucleosomes modulate CPD formation, favoring outside facing sites and disfavoring inward facing sites. A similar pattern of CPD formation in protein-free ... | ['Animals', 'Chickens', 'DNA, Circular', 'Deamination', 'Erythrocytes', 'Histones', 'Humans', 'Mutagenesis', 'Nucleic Acid Conformation', 'Nucleosomes', 'Pyrimidine Dimers', 'Thymine', 'Ultraviolet Rays'] | 28,525,579 | [['B01.050'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['D13.444.308.283', 'G02.111.570.820.486.212', 'G05.360.580.156'], ['G02.111.192', 'G02.607.157', 'G03.222'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['D12.776.157.687.485', 'D12.776.660.720.485', 'D12.776.664.469'], ['B01.050.150.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
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