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GluA2 trafficking is involved in apoptosis of retinal ganglion cells induced by activation of EphB/EphrinB reverse signaling in a rat chronic ocular hypertension model. | EphB1, expressed in M?ller cells, and ephrinB2, expressed in both M?ller cells and retinal ganglion cells (RGCs), constitute an EphB/ephrinB reverse signaling in RGCs. Whether and how this reverse signaling is involved in RGC apoptosis in a rat chronic ocular hypertension (COH) model was investigated. In the COH model,... | ['Animals', 'Apoptosis', 'Disease Models, Animal', 'Ephrin-B2', 'Excitatory Postsynaptic Potentials', 'In Situ Nick-End Labeling', 'Male', 'Ocular Hypertension', 'Phosphorylation', 'Protein Transport', 'Pyrimidines', 'Rats', 'Receptor, EphB1', 'Receptors, AMPA', 'Retinal Ganglion Cells', 'Signal Transduction', 'src-Fam... | 25,834,064 | [['B01.050'], ['G04.146.954.035'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['D12.644.276.500.700', 'D12.776.467.500.700', 'D12.776.543.287.700', 'D23.529.500.700'], ['G04.580.887.249', 'G07.265.675.887.249', 'G07.265.880.750.199', 'G11.561.570.918.249', 'G11.561.830.750.199'], ['E05.393.475'], ['C11.525'], ['G02... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Treatment of diabetic patients with insulin resistance and allergy using des-phe-insulin (author's transl)]. | Eleven patients were treated with pure porcine des-phe-insulin (Insulin 02S Hoechst). In seven patients insulin 02S was used because of high insulin requirements. Three cases were treated successfully, one case moderately successfully, there was no success in two cases and in one case the result remains to be seen. In ... | ['Aged', 'Animals', 'Diabetes Mellitus', 'Drug Hypersensitivity', 'Female', 'Humans', 'Insulin', 'Insulin Antibodies', 'Insulin Resistance', 'Male', 'Middle Aged', 'Swine'] | 499,001 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Long-Term Follow-up Study of MRI-Guided Bilateral Anterior Capsulotomy in Patients With Refractory Anorexia Nervosa. | BACKGROUND: Anorexia nervosa (AN) is one of the most challenging psychiatric disorders to treat. The poor clinical outcomes warrant novel treatments for AN, especially in severe and persistent cases.OBJECTIVE: To explore the feasibility of magnetic resonance imaging-guided bilateral anterior capsulotomy in the treatmen... | ['Adolescent', 'Adult', 'Anorexia Nervosa', 'Catheter Ablation', 'Female', 'Follow-Up Studies', 'Humans', 'Internal Capsule', 'Magnetic Resonance Imaging', 'Middle Aged', 'Stereotaxic Techniques', 'Surgery, Computer-Assisted', 'Treatment Outcome', 'Young Adult'] | 28,945,886 | [['M01.060.057'], ['M01.060.116'], ['F03.400.125'], ['E02.808.750.500', 'E04.014.760.500'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A08.186.211.200.885.385', 'A08.612.435'], ['E01.370.350.825.500'], ['M01.060.116.630']... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Effect of cimetidine on absorption of oral tetracycline in mice. | Gastric administration of cimetidine, 5 mg/kg, and magnesium aluminum hydroxide gel (Maalox), 1 ml/kg, were equally effective raising the gastric pH of mice from 2.5 to 5.0. The antacid depressed by 75% gastrointestinal absorption of tetracycline given by gastric tube at 25 mg/kg. Antibiotic bioavailability was measure... | ['Administration, Oral', 'Aluminum Hydroxide', 'Animals', 'Antacids', 'Cimetidine', 'Drug Interactions', 'Gastric Juice', 'Guanidines', 'Hydrogen-Ion Concentration', 'Intestinal Absorption', 'Male', 'Mice', 'Tetracycline', 'Time Factors'] | 7,384,196 | [['E02.319.267.100'], ['D01.045.250.050', 'D01.056.037', 'D01.248.497.158.459.075'], ['B01.050'], ['D27.505.519.170', 'D27.505.954.483.080'], ['D02.078.370.200', 'D03.383.129.308.130'], ['G07.690.773.968'], ['A12.200.307'], ['D02.078.370'], ['G02.300'], ['G03.015.500.374.500', 'G03.787.024.500.374.500', 'G07.203.650.37... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Association between musculoskeletal disorders in the lower limbs and occupational stress in bus drivers]. | Objective: To investigate the prevalence of work-related musculoskeletal disorders (MSDs) in the lower limbs and occupational stress in bus drivers, as well as the association between occupational stress and MSDs in the lower limbs, and to provide a reference for the prevention and control of MSDs in the lower limbs in... | ['Automobile Driving', 'China', 'Cross-Sectional Studies', 'Humans', 'Lower Extremity', 'Musculoskeletal Diseases', 'Occupational Diseases', 'Prevalence', 'Reward', 'Risk Factors', 'Surveys and Questionnaires'] | 27,682,661 | [['I03.125'], ['Z01.252.474.164'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A01.378.610'], ['C05'], ['C24'], ['E05.318.308.985.525.750', 'N01.224.935.597.750', 'N06.850.505.400.975.525.750', 'N06.850.520.308.985.525.750'], ['F02.46... | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Age and response bias: evidence from the strength-based mirror effect. | Performance in episodic memory is determined both by accurate retrieval from memory and by decision processes. A substantial body of literature suggests slightly poorer episodic memory accuracy for older than younger adults; however, age-related changes in the decision mechanisms in memory have received much less atten... | ['Adolescent', 'Aged', 'Aging', 'Association Learning', 'Bias', 'Female', 'Humans', 'Male', 'Memory, Episodic', 'Middle Aged', 'Models, Psychological', 'Recognition, Psychology', 'Verbal Learning', 'Young Adult'] | 24,386,987 | [['M01.060.057'], ['M01.060.116.100'], ['G07.345.124'], ['F02.463.425.069.296'], ['N05.715.350.150', 'N06.850.490.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.425.540.254'], ['M01.060.116.630'], ['E05.599.695'], ['F02.463.425.540.706'], ['F02.463.425.952'], ['M01.060.116.815']] | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Estimation of the free [Ca2+] gradient across endoplasmic reticulum membranes by a null-point method. | The rate of unidirectional efflux of 45Ca from rat liver microsomal vesicles loaded with 45Ca and then treated with thapsigargin is not inhibited by increased [Ca2+] in the external medium, although the net efflux rate is substantially inhibited. We have used this property to measure the electrochemical gradient of Ca2... | ['Animals', 'Calcium', 'Calcium-Transporting ATPases', 'Cell Membrane Permeability', 'Digitonin', 'Endoplasmic Reticulum', 'Kinetics', 'Leukemia L1210', 'Liver', 'Male', 'Mice', 'Microsomes, Liver', 'Rats', 'Terpenes', 'Thapsigargin', 'Tumor Cells, Cultured'] | 7,654,169 | [['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D08.811.277.040.025.314.250', 'D12.776.157.530.450.250.500', 'D12.776.157.530.813.250', 'D12.776.543.585.450.250.500', 'D12.776.543.585.813.250'], ['G03.143.335', 'G04.175'], ['D04.210.500.155.580.130.500.236', 'D09.408.180.261.236'], ['A11.284.430.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Shear stress augments the enhanced adhesive phenotype of cells expressing the Pro33 isoform of integrin beta3. | Adhesion of platelets to the exposed extracellular matrix proteins at sites of vascular injury is partly regulated by the local fluid shear stress. Because the Leu33Pro (Pl(A)) polymorphism of integrin beta(3) confers only a modest increase in adhesion under static conditions, we used CHO and 293 cells expressing the L... | ['Animals', 'CHO Cells', 'Cell Adhesion', 'Cell Line', 'Cricetinae', 'Fibrinogen', 'Fibronectins', 'Flow Cytometry', 'Fluorescent Antibody Technique', 'Humans', 'Integrin beta3', 'Proline', 'Prostaglandin-Endoperoxide Synthases'] | 12,681,480 | [['B01.050'], ['A11.251.210.200', 'A11.436.155'], ['G04.022'], ['A11.251.210'], ['B01.050.150.900.649.313.992.635.075.250'], ['D12.776.124.050.250', 'D12.776.124.125.500', 'D12.776.811.300', 'D23.119.490'], ['D12.776.377.715.390', 'D12.776.395.550.350', 'D12.776.543.550.350', 'D12.776.860.300.450'], ['E01.370.225.500.3... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Metabolic changes in the psoriatic lesion during therapy. | Three marker enzymes were measured during treatment of psoriatic plaques with two different therapies. During treatment with clobetasol propionate the epidermal enzymes (acid phosphatase and glucose-6-phosphate dehydrogenase) returned to normal within 14 days whereas capillary alkaline phosphatase remained at the origi... | ['Acid Phosphatase', 'Alkaline Phosphatase', 'Betamethasone', 'Clobetasol', 'Epidermis', 'Glucosephosphate Dehydrogenase', 'Humans', 'PUVA Therapy', 'Photochemotherapy', 'Psoriasis', 'Time Factors'] | 6,712,885 | [['D08.811.277.352.650.025'], ['D08.811.277.352.650.035'], ['D04.210.500.745.432.769.199', 'D04.210.500.908.093'], ['D04.210.500.908.093.250'], ['A10.272.497', 'A17.815.250'], ['D08.811.682.047.150.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.774.945.500'], ['E02.186.500', 'E02.319.685', 'E02.774.722']... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Molecular taxonomic study of Chagas disease vectors from the phyllosoma, lecticularia, and rubrofasciata complexes. | The Triatiominae (Hemiptera: Reduviidae) are hematophagous hemipters of importance because they transmit Trypanosoma cruzi, the causal agent of Chagas disease. The aim of this study was to define the possible relationships between species of the Phyllosoma complex (Triatoma mazzottii, Triatoma pallidipennis, and Triato... | ['Animals', 'Chagas Disease', 'Electrophoresis, Cellulose Acetate', 'Insect Vectors', 'Isoenzymes', 'Mexico', 'Phylogeny', 'Polymorphism, Genetic', 'Species Specificity', 'Triatoma', 'Trypanosoma cruzi'] | 16,103,598 | [['B01.050'], ['C01.610.752.300.900.200', 'C01.920.625'], ['E05.196.401.200', 'E05.301.300.200'], ['N06.850.335.188.100.500', 'N06.850.520.203.375.100.500'], ['D08.811.348', 'D12.776.800.300'], ['Z01.107.567.589'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['G05.365.795'], ['G16.824'], ['B01.050.500.131.617.412.420.70... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Information Science [L]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 |
Olfactory toxicity of beta,beta'-iminodipropionitrile in the rat. | Following a pilot study which revealed olfactory epithelial degeneration induced by beta,beta'-iminodipropionitrile (IDPN), dose-response and time-course analyses were undertaken to further characterize the effects of IDPN on the olfactory system. Male rats were sacrificed at multiple time points ranging from 24 hr aft... | ['Animals', 'Dose-Response Relationship, Drug', 'Glial Fibrillary Acidic Protein', 'Immunohistochemistry', 'Male', 'Nitriles', 'Olfactory Bulb', 'Olfactory Mucosa', 'Rats'] | 1,469,644 | [['B01.050'], ['G07.690.773.875', 'G07.690.936.500'], ['D05.750.078.593.400', 'D12.776.220.475.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512', 'H01.158.201.344.512', 'H01.158.201.486.512', 'H01.181.122.573.512', 'H01.1... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Prevalence and predictors of asthma in working groups in British Columbia. | We evaluated the prevalence of asthma and its predictors in studies of several male working groups: 619 cedar sawmill, 724 grain elevator, 399 pulpmill, 798 aluminum smelter, and 1,127 unexposed workers. These workers had taken part in health studies for assessment of chronic respiratory effects of various workplace ex... | ['Adult', 'Aluminum', 'Asthma', 'British Columbia', 'Humans', 'Hypersensitivity, Immediate', 'Male', 'Metallurgy', 'Occupational Diseases', 'Occupations', 'Prevalence', 'Risk Factors', 'Smoking', 'Time Factors', 'Triticum', 'Wood'] | 7,485,194 | [['M01.060.116'], ['D01.268.557.050', 'D01.552.547.050'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['Z01.107.567.176.160'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C20.543.480'], ['J01.576.655.875.400'], ['C24'], ['N01.824.547'], ['E05.318.308.985.525.750', 'N01.224.935.597.7... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Geographicals [Z]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
Cryo-EM structures and functional characterization of the murine lipid scramblase TMEM16F. | The lipid scramblase TMEM16F initiates blood coagulation by catalyzing the exposure of phosphatidylserine in platelets. The protein is part of a family of membrane proteins, which encompasses calcium-activated channels for ions and lipids. Here, we reveal features of murine TMEM16F (mTMEM16F) that underlie its function... | ['Anoctamins', 'Calcium', 'Cations, Divalent', 'Cryoelectron Microscopy', 'Ion Channels', 'Phospholipid Transfer Proteins', 'Protein Conformation'] | 30,785,399 | [['D12.776.157.530.400.175.032', 'D12.776.543.550.450.175.032', 'D12.776.543.585.400.175.032'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D01.248.497.300.333'], ['E01.370.350.515.402.150', 'E05.595.402.150'], ['D12.776.157.530.400', 'D12.776.543.550.450', 'D12.776.543.585.400'], ['D12.776.157.674', 'D12.... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Early Activation of MAPK and Apoptosis in Nutritive Embryos of Calyptraeid Gastropods. | Investigation of alternative phenotypes, different morphologies produced by a single genome, has contributed novel insights into development and evolution. Yet, the mechanisms underlying developmental switch points between alternative phenotypes remain poorly understood. The calyptraeid snails Crepidula navicella and C... | ['Animals', 'Apoptosis', 'Embryo, Nonmammalian', 'Embryonic Development', 'Gene Expression Regulation, Developmental', 'Gene Expression Regulation, Enzymologic', 'Mitogen-Activated Protein Kinase Kinases', 'Snails'] | 28,656,657 | [['B01.050'], ['G04.146.954.035'], ['A13.350', 'A16.331'], ['G07.345.500.325.180', 'G08.686.784.170.104'], ['G05.308.310'], ['G05.308.320'], ['D08.811.913.696.620.682.700.565', 'D08.811.913.696.620.682.725.200', 'D12.644.360.440', 'D12.776.476.440'], ['B01.050.500.644.400.750']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Occurrence and microbial degradation of phthalate esters in Taiwan river sediments. | Concentrations and microbial degradation rates were measured for eight phthalate esters (PAEs) found in 14 surface water and six sediment samples taken from rivers in Taiwan. The tested PAEs were diethyl phthalate (DEP), dipropyl phthalate (DPP), di-n-butyl phthalate (DBP), diphenyl phthalate (DPhP), benzylbutyl phthal... | ['Bacteria, Anaerobic', 'Biodegradation, Environmental', 'Environmental Monitoring', 'Esters', 'Half-Life', 'Phthalic Acids', 'Taiwan', 'Water Pollutants, Chemical'] | 12,489,726 | [['B03.130'], ['N06.230.080.600.500', 'N06.850.460.375.500'], ['N06.850.460.350.080', 'N06.850.780.375'], ['D02.241.400'], ['G01.910.405'], ['D02.241.223.805'], ['Z01.252.474.872', 'Z01.639.850'], ['D27.888.284.903.655']] | ['Organisms [B]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Is styrene planar in liquid phases? | The proton NMR spectra of two (13)C-labeled isotopomers of styrene dissolved in two liquid crystalline solvents have been obtained and analyzed to yield four sets each of 24 dipolar couplings. These couplings were then used to investigate the structure of the ring and the ene fragments of the molecule, and the position... | ['Carbon Radioisotopes', 'Chemistry, Physical', 'Magnetic Resonance Spectroscopy', 'Models, Chemical', 'Models, Molecular', 'Models, Statistical', 'Molecular Conformation', 'Solutions', 'Styrene'] | 15,267,611 | [['D01.268.150.075.328', 'D01.496.123.328', 'D01.496.749.154'], ['H01.181.529'], ['E05.196.867.519'], ['E05.599.495'], ['E05.599.595'], ['E05.318.740.500', 'E05.599.835', 'N05.715.360.750.530', 'N06.850.520.830.500'], ['G02.111.570.820'], ['D26.776'], ['D02.455.426.559.389.150.750.800']] | ['Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Bioaccumulation of metals and PCBs in Raja clavata. | The goal of this study was to assess stable isotopes profiles, metals concentration and PCBs in Raja clavata muscle and liver, according to sex and size, and to elucidate its suitability as a Mid-Atlantic biomonitor. The results reflected bioaccumulation and suggested biomagnification processes for As and Hg in muscle ... | ['Animals', 'Atlantic Ocean', 'Azores', 'Environmental Monitoring', 'Female', 'Liver', 'Male', 'Metals, Heavy', 'Muscles', 'Polychlorinated Biphenyls', 'Skates, Fish', 'Water Pollutants, Chemical'] | 27,607,905 | [['B01.050'], ['Z01.756.092'], ['Z01.639.040.218'], ['N06.850.460.350.080', 'N06.850.780.375'], ['A03.620'], ['D01.268.556', 'D01.552.544'], ['A02.633', 'A10.690'], ['D02.309.750', 'D02.455.426.559.389.185.698', 'D02.455.526.439.773'], ['B01.050.150.900.493.370.870', 'B01.050.150.900.493.378.682'], ['D27.888.284.903.65... | ['Organisms [B]', 'Geographicals [Z]', 'Health Care [N]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Differential roles of HIC-5 isoforms in the regulation of cell death and myotube formation during myogenesis. | Hic-5 is a LIM-Only member of the paxillin superfamily of focal adhesion proteins. It has been shown to regulate a range of biological processes including: senescence, tumorigenesis, steroid hormone action, integrin signaling, differentiation, and apoptosis. To better understand the roles of Hic-5 during development, w... | ['Animals', 'Apoptosis', 'Cell Differentiation', 'Cell Line', 'Cytoskeletal Proteins', 'DNA-Binding Proteins', 'Focal Adhesions', 'Integrins', 'LIM Domain Proteins', 'Mice', 'Muscle Development', 'Muscle Fibers, Skeletal', 'Myoblasts', 'Protein Isoforms', 'Signal Transduction'] | 17,935,713 | [['B01.050'], ['G04.146.954.035'], ['G04.152'], ['A11.251.210'], ['D12.776.220'], ['D12.776.260'], ['A11.284.149.165.165.285'], ['D12.776.543.750.705.408'], ['D12.776.512'], ['B01.050.150.900.649.313.992.635.505.500'], ['G07.345.500.325.377.625.590', 'G11.427.578.590'], ['A10.690.552.500.500', 'A11.620.249'], ['A11.872... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cooperative prosurvival activity by ERK and Akt in human alveolar macrophages is dependent on high levels of acid ceramidase activity. | Human alveolar macrophages are unique in that they have an extended life span in contrast to precursor monocytes. In evaluating the role of sphingolipids in alveolar macrophage survival, we found high levels of sphingosine, but not sphingosine-1-phosphate. Sphingosine is generated by the action of ceramidase(s) on cera... | ['Cell Survival', 'Cells, Cultured', 'Galactosylgalactosylglucosylceramidase', 'Humans', 'Macrophages, Alveolar', 'Mitogen-Activated Protein Kinases', 'Protein Kinase C-delta', 'Protein-Serine-Threonine Kinases', 'Proto-Oncogene Proteins', 'Proto-Oncogene Proteins c-akt', 'RNA, Messenger', 'Sphingosine'] | 15,210,766 | [['G04.346'], ['A11.251'], ['D08.811.277.450.410.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.329.372.600', 'A11.627.482.600', 'A11.733.397.600', 'A15.382.670.522.600', 'A15.382.680.397.600'], ['D08.811.913.696.620.682.700.567', 'D12.644.360.450', 'D12.776.476.450'], ['D08.811.913.696.620.682.700.725.4... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Personalized cancer vaccine effectively mobilizes antitumor T cell immunity in ovarian cancer. | We conducted a pilot clinical trial testing a personalized vaccine generated by autologous dendritic cells (DCs) pulsed with oxidized autologous whole-tumor cell lysate (OCDC), which was injected intranodally in platinum-treated, immunotherapy-na?ve, recurrent ovarian cancer patients. OCDC was administered alone (cohor... | ['Antigens, Neoplasm', 'Bevacizumab', 'Cancer Vaccines', 'Cyclophosphamide', 'Dendritic Cells', 'Female', 'Humans', 'Immunotherapy', 'Mutation', 'Ovarian Neoplasms', 'T-Lymphocytes, Cytotoxic'] | 29,643,231 | [['D23.050.285'], ['D12.776.124.486.485.114.224.060.375', 'D12.776.124.790.651.114.224.060.438', 'D12.776.377.715.548.114.224.200.438'], ['D20.215.894.200'], ['D02.455.526.728.650.730.243', 'D02.705.672.500.243'], ['A11.066.270', 'A11.436.270', 'A15.382.066.270', 'A15.382.670.260'], ['B01.050.150.900.649.313.988.400.11... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Intracellular Ca2+ stores could participate to abscisic acid-induced depolarization and stomatal closure in Arabidopsis thaliana. | In Arabidopsis thaliana cell suspension, abscisic acid (ABA) induces changes in cytosolic calcium concentration ([Ca(2+)](cyt)) which are the trigger for ABA-induced plasma membrane anion current activation, H(+)-ATPase inhibition, and subsequent plasma membrane depolarization. In the present study, we took advantage o... | ['Abscisic Acid', 'Alkalies', 'Arabidopsis', 'Calcium', 'Culture Media', 'Extracellular Space', 'Inositol 1,4,5-Trisphosphate Receptors', 'Intracellular Space', 'Ion Channel Gating', 'Membrane Potentials', 'Plant Stomata', 'Ryanodine Receptor Calcium Release Channel', 'Time Factors'] | 19,847,112 | [['D02.241.223.268.034', 'D02.455.326.271.665.202.061', 'D02.455.426.392.368.367.379.249.024', 'D02.455.849.131.061', 'D02.455.849.765.521.500'], ['D01.045'], ['B01.650.940.800.575.912.250.157.100'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D27.720.470.305', 'E07.206'], ['A10.082.500', 'A11.284.295'], [... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Inhibition of RNA polymerase from Bacillus thuringiensis and Escherichia coli by beta-exotoxin. | The characteristics of exotoxin inhibition of deoxyribonucleic acid (DNA) dependent ribonucleic acid (RNA) polymerase isolated from Escherichia coli and Bacillus thuringiensis were investigated. RNA polymerase isolated from a variety of growth stages was partially purified and assayed using several different native and... | ['Bacillus thuringiensis', 'Bacterial Toxins', 'DNA-Directed RNA Polymerases', 'Escherichia coli', 'Exotoxins', 'Spores, Bacterial'] | 350,363 | [['B03.300.390.400.158.218.800', 'B03.353.500.100.218.800', 'B03.510.100.100.218.800', 'B03.510.415.400.158.218.800', 'B03.510.460.410.158.218.800'], ['D23.946.123'], ['D08.811.913.696.445.735.270'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D23.946.350'], ['A11.870.700', 'B05.775.700']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Calculated insulin resistance correlates with stone-forming urinary metabolic changes and greater stone burden in high-risk stone patients. | AIMS: Metabolic syndrome and diabetes are associated with nephrolithiasis. Proposed mechanisms of lithogenesis include insulin resistance causing low urine pH and hyperinsulinemia leading to hypercalciuria. Herein, we sought to determine whether insulin resistance was associated with differences in stone burden and lit... | ['Adolescent', 'Adult', 'Aged', 'Calcium', 'Citric Acid', 'Female', 'Humans', 'Hydrogen-Ion Concentration', 'Insulin', 'Insulin Resistance', 'Kidney Calculi', 'Male', 'Middle Aged', 'Severity of Illness Index', 'Tomography, X-Ray Computed', 'Urinalysis', 'Young Adult'] | 27,125,629 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D02.241.081.901.434.249'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.300'], ['D06.472.699.587.200.500.625', 'D12.644.548.586.200.500.625'], ['C18.452.394.968.500', 'G07.690.773.984.617'], ['C12.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Differential processing of RNA transcribed from the single-copy Drosophila myosin heavy chain gene produces four mRNAs that encode two polypeptides. | We report the sequence of genomic DNA at the 3' end of the single-copy Drosophila myosin heavy chain (MHC) gene and the structure and sequence at the 3' end of four MHC mRNAs. Two mRNAs, 7.2-kilobases (kb) and 8.0 kb in length, are expressed in all stages of development in which detectable levels of muscle-specific mRN... | ['Animals', 'Base Sequence', 'Drosophila melanogaster', 'Myosins', 'RNA Processing, Post-Transcriptional', 'RNA Splicing', 'RNA, Messenger'] | 3,083,414 | [['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['B01.050.500.131.617.720.500.500.750.310.250.500'], ['D05.750.078.730.475', 'D08.811.277.040.025.193.750', 'D12.776.210.500.600', 'D12.776.220.525.475'], ['G02.111.760', 'G03.839', 'G05.308.700'], ['G02.111.760.700', 'G03.839.700', 'G05.308.700.7... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Can I tell you how I feel? Perceived partner responsiveness encourages emotional expression. | When do people express their emotions to other people and when do they choose not to do so? Emotional experience-positive or negative-often leads people to reveal their feelings to others, especially to close relationship partners. Although emotional expression has been incorporated into recent dyadic models of emotion... | ['Adolescent', 'Adult', 'Expressed Emotion', 'Female', 'Humans', 'Interpersonal Relations', 'Male', 'Stress, Psychological', 'Young Adult'] | 31,414,835 | [['M01.060.057'], ['M01.060.116'], ['F01.829.197'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.401'], ['F01.145.126.990', 'F02.830.900'], ['M01.060.116.815']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Identification of introns harboring functional sequence elements through positional conservation. | Many human introns carry out a function, in the sense that they are critical to maintain normal cellular activity. Their identification is fundamental to understanding cellular processes and disease. However, being noncoding elements, such functional introns are poorly predicted based on traditional approaches of seque... | ['Animals', 'Base Sequence', 'Conserved Sequence', 'Databases, Genetic', 'Discriminant Analysis', 'Genome', 'Humans', 'Introns', 'MicroRNAs', 'Models, Statistical', 'Open Reading Frames', 'RNA Processing, Post-Transcriptional', 'RNA, Messenger', 'RNA, Small Nucleolar'] | 28,646,210 | [['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G02.111.570.580'], ['L01.313.500.750.300.188.400.325', 'L01.470.750.750.325'], ['E05.318.740.350', 'N05.715.360.750.325', 'N06.850.520.830.350'], ['G05.360.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G05.360.340.024.220.400', 'G05.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Life cycle assessment of bagasse waste management options. | Bagasse is mostly utilized for steam and power production for domestic sugar mills. There have been a number of alternatives that could well be applied to manage bagasse, such as pulp production, conversion to biogas and electricity production. The selection of proper alternatives depends significantly on the appropria... | ['Biodegradation, Environmental', 'Cellulose', 'Environment', 'Methane', 'Models, Theoretical', 'Refuse Disposal', 'Waste Management'] | 19,136,243 | [['N06.230.080.600.500', 'N06.850.460.375.500'], ['D05.750.078.562.180', 'D09.698.365.180', 'D25.720.099.500', 'J01.637.051.720.099.500'], ['G16.500.275', 'N06.230'], ['D02.455.326.146.571'], ['E05.599'], ['N06.850.780.200.800.800.700', 'N06.850.860.510.900.600'], ['N06.850.780.200.800.800.900', 'N06.850.860.510.900']] | ['Health Care [N]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Quantitative trait locus dissection in congenic strains of the Goto-Kakizaki rat identifies a region conserved with diabetes loci in human chromosome 1q. | Genetic studies in human populations and rodent models have identified regions of human chromosome 1q21-25 and rat chromosome 2 showing evidence of significant and replicated linkage to diabetes-related phenotypes. To investigate the relationship between the human and rat diabetes loci, we fine mapped the rat locus Nid... | ['Animals', 'Animals, Congenic', 'Body Weight', 'Chromosomes, Human, Pair 1', 'Conserved Sequence', 'Crosses, Genetic', 'Diabetes Mellitus, Type 2', 'Female', 'Gene Expression Profiling', 'Genomics', 'Glucose', 'Glucose Intolerance', 'Humans', 'Hyperinsulinism', 'Insulin', 'Insulin Secretion', 'Lipids', 'Male', 'Phenot... | 15,266,047 | [['B01.050'], ['B01.050.050.199.520.040'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['A11.284.187.520.300.235.240', 'G05.360.162.520.300.235.240'], ['G02.111.570.580'], ['E05.393.281'], ['C18.452.394.750.149', 'C19.246.300'], ['E05.393.332'], [... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Presynaptic N-type calcium channels regulate synaptic growth. | Voltage-gated calcium channels couple changes in membrane potential to neuronal functions regulated by calcium, including neurotransmitter release. Here we report that presynaptic N-type calcium channels not only control neurotransmitter release but also regulate synaptic growth at Drosophila neuromuscular junctions. I... | ['Alleles', 'Amino Acid Sequence', 'Animals', 'Calcium', 'Calcium Channels', 'Calcium Channels, N-Type', 'DNA', 'Dose-Response Relationship, Drug', 'Drosophila', 'Drosophila Proteins', 'Electrophysiology', 'Immunohistochemistry', 'Microscopy, Fluorescence', 'Models, Biological', 'Molecular Sequence Data', 'Mutation', '... | 12,896,973 | [['G05.360.340.024.340.030'], ['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D12.776.157.530.400.150', 'D12.776.543.550.450.150', 'D12.776.543.585.400.150'], ['D12.776.157.530.400.150.585', 'D12.776.543.550.450.150.585', 'D12.776.543.585.400.150.585'], ... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
DNA duplexes containing methylated bases or non-nucleotide inserts in the recognition site are cleaved by restriction endonuclease R.EcoRII in presence of canonical substrate. | DNA duplexes containing the natural methylated bases N6-methyladenine (m6Ade), N4-methylcytosine (m4Cyt) or C5-methylcytosine (m5Cyt) in one strand of the recognition sequence are resistant to EcoRII restriction endonuclease (R.EcoRII). Hydrolysis of these modified duplexes was observed in the presence of the canonical... | ['5-Methylcytosine', 'Adenine', 'Base Sequence', 'Cytosine', 'DNA', 'Deoxyribonucleases, Type II Site-Specific', 'Methylation', 'Molecular Sequence Data', 'Oligodeoxyribonucleotides', 'Substrate Specificity'] | 7,607,486 | [['D03.383.742.698.421.500'], ['D03.633.100.759.138'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D03.383.742.698.421'], ['D13.444.308'], ['D08.811.150.280.260', 'D08.811.277.352.335.350.300.260', 'D08.811.277.352.355.325.300.260'], ['G02.111.035.538', 'G02.607.094.538', 'G03.059.538'], ['L01.453.245.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Post-traumatic stress disorder, child abuse history, birthweight and gestational age: a prospective cohort study. | OBJECTIVE: To determine the extent to which prenatal post-traumatic stress disorder (PTSD) is associated with lower birthweight and shorter gestation, and to explore the effects of childhood maltreatment as the antecedent trauma exposure.DESIGN: Prospective three-cohort study.SETTING: Ann Arbor and Detroit, Michigan, U... | ['Adolescent', 'Adult', 'Adult Survivors of Child Abuse', 'Birth Weight', 'Female', 'Gestational Age', 'Humans', 'Linear Models', 'Pregnancy', 'Pregnancy Outcome', 'Prospective Studies', 'Spouse Abuse', 'Stress Disorders, Post-Traumatic', 'Young Adult'] | 21,790,957 | [['M01.060.057'], ['M01.060.116'], ['M01.135.500', 'M01.860.300.500'], ['C23.888.144.186', 'E01.370.600.115.100.160.120.186', 'E05.041.124.160.750.149', 'G07.100.100.160.120.186', 'G07.345.249.314.120.186'], ['G07.345.500.325.235.968', 'G08.686.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.5... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Factors associated with supportive care needs in glioma patients in the neuro-oncological outpatient setting. | Objective of this study aimed at assessing glioma patients' supportive care needs in a neurosurgical outpatient setting and identifying factors that are associated with needs for support. In three neuro-oncological outpatient departments, glioma patients were assessed for their psychosocial needs using the Supportive C... | ['Activities of Daily Living', 'Adult', 'Age Factors', 'Aged', 'Brain Neoplasms', 'Communication', 'Female', 'Glioma', 'Health Services Needs and Demand', 'Humans', 'Karnofsky Performance Status', 'Male', 'Middle Aged', 'Needs Assessment', 'Neoplasm Grading', 'Outpatients', 'Patient-Centered Care', 'Sex Factors', 'Sexu... | 28,527,007 | [['E02.760.169.063.500.067', 'E02.831.067', 'I03.050', 'N02.421.784.110'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['F01.145.209', 'L01.143'], ['C04.557.465.625.600.380', 'C04.557.470.670.380', 'C04.557.580.625.600.380'... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Information Science [L]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 0 |
Identifying the Atomic-Level Effects of Metal Composition on the Structure and Catalytic Activity of Peptide-Templated Materials. | Bioinspired approaches for the formation of metallic nanomaterials have been extensively employed for a diverse range of applications including diagnostics and catalysis. These materials can often be used under sustainable conditions; however, it is challenging to control the material size, morphology, and composition ... | ['Catalysis', 'Gold', 'Hydrophobic and Hydrophilic Interactions', 'Metal Nanoparticles', 'Peptides', 'Silver', 'X-Ray Diffraction'] | 26,497,843 | [['G02.130'], ['D01.268.556.322', 'D01.268.956.186', 'D01.552.544.322'], ['G02.409'], ['J01.637.512.600.500'], ['D12.644'], ['D01.268.556.812', 'D01.268.956.843', 'D01.552.544.812'], ['E05.196.309.742', 'E05.196.822.950', 'G01.867.950', 'G02.965']] | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Effects of repeated doses of enalapril on renal function in man. | Ten healthy subjects received 10 mg oral enalapril (MK 421) daily for a period of 8 days. Renal clearances of electrolytes, urate and phosphate were monitored and factored for glomerular filtration rate, as measured by creatinine clearance, with particular emphasis on the first and eighth day of treatment. Apart from a... | ['Adult', 'Angiotensin-Converting Enzyme Inhibitors', 'Antihypertensive Agents', 'Creatinine', 'Dipeptides', 'Enalapril', 'Enalaprilat', 'Glomerular Filtration Rate', 'Humans', 'Hydrogen-Ion Concentration', 'Kidney', 'Male', 'Potassium', 'Sodium', 'Uric Acid'] | 2,985,103 | [['M01.060.116'], ['D27.505.519.389.745.085'], ['D27.505.954.411.162'], ['D03.383.129.308.207'], ['D12.644.456.345'], ['D12.644.456.345.360'], ['D12.644.456.345.360.300'], ['E01.370.390.400.300', 'G08.852.357'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.300'], ['A05.810.453'], ['D01.268.549.550', 'D01.268.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Therapeutic effects of topical netrin-4 inhibits corneal neovascularization in alkali-burn rats. | Netrins are secreted molecules involved in axon guidance and angiogenesis. However, the role of netrins in the vasculature remains unclear. Netrin-4 and netrin-1 have been found to be either pro- or antiangiogenic factors. Previously, we found that netrin-1 acts as an anti-angiogenic factor in rats by inhibiting alkali... | ['Administration, Topical', 'Alkalies', 'Animals', 'Apoptosis', 'Cell Proliferation', 'Cornea', 'Corneal Neovascularization', 'Eye Burns', 'Human Umbilical Vein Endothelial Cells', 'Humans', 'Mice', 'Nerve Growth Factors', 'Netrin-1', 'Netrins', 'Rats', 'Recombinant Proteins', 'Tumor Suppressor Proteins'] | 25,853,509 | [['E02.319.267.120'], ['D01.045'], ['B01.050'], ['G04.146.954.035'], ['G04.161.750', 'G07.345.249.410.750'], ['A09.371.060.217'], ['C11.204.290', 'C23.550.589.500.435'], ['C10.900.300.284.250.250', 'C26.200.503', 'C26.915.300.425.250.250'], ['A11.436.275.682'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Decentralization in the New York City Department of Health: reorganization of a public health agency. | Since the World War I era there has existed within the New York City Department of Health a basic internal struggle between staff directing the bureaus at the central office and the district health officers operating field health centers throughout the city. Recently, in a five-year period, there was a dramatic reorgan... | ['Administrative Personnel', 'Community Health Services', 'Delivery of Health Care', 'History of Medicine', 'New York City', 'Public Health', 'Public Health Administration'] | 795,307 | [['M01.526.070'], ['N02.421.143'], ['N04.590.374', 'N05.300'], ['K01.400.552'], ['Z01.107.567.875.350.530.530', 'Z01.107.567.875.500.530.530', 'Z01.433.741'], ['H02.403.720', 'N01.400.550', 'N06.850'], ['N04.452.794']] | ['Named Groups [M]', 'Health Care [N]', 'Humanities [K]', 'Geographicals [Z]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
Improved retention of endothelial cells seeded on polyurethane small-diameter vascular grafts modified by a recombinant RGD-containing protein. | Sponge-type small-diameter vascular grafts were fabricated from a medical-grade polyurethane, Pellethane 2363-80A, by utilization of a salt casting technique. The grafts were compliance matched with a storage modulus of 0.53 +/- 0.08 MPa. The luminal surface of grafts was modified with a thin layer ( approximately 40 m... | ['Animals', 'Biocompatible Materials', 'Blood Vessel Prosthesis', 'Cell Adhesion', 'Cellulose', 'Dogs', 'Endothelial Cells', 'Humans', 'Oligopeptides', 'Platelet Activation', 'Polyurethanes', 'Prosthesis Design', 'Tissue Engineering'] | 14,678,420 | [['B01.050'], ['D25.130', 'D27.720.102.130', 'J01.637.051.130'], ['E07.695.110'], ['G04.022'], ['D05.750.078.562.180', 'D09.698.365.180', 'D25.720.099.500', 'J01.637.051.720.099.500'], ['B01.050.150.900.649.313.750.250.216.200'], ['A11.436.275'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.456'], ['G09.1... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
O-GlcNAcylation promotes colorectal cancer metastasis via the miR-101-O-GlcNAc/EZH2 regulatory feedback circuit. | Advanced colorectal cancer (CRC) is one of the deadliest cancers, and the 5-year survival rate of patients with metastasis is extremely low. The epithelial-mesenchymal transition (EMT) is considered essential for metastatic CRC, but the fundamental molecular basis underlying this effect remains unknown. Here, we identi... | ['Acetylglucosamine', 'Adenocarcinoma', 'Cell Line, Tumor', 'Colorectal Neoplasms', 'Enhancer of Zeste Homolog 2 Protein', 'Epithelial-Mesenchymal Transition', 'Feedback, Physiological', 'Feeding Behavior', 'Gene Expression Regulation, Neoplastic', 'Humans', 'Kaplan-Meier Estimate', 'Lymphatic Metastasis', 'MicroRNAs',... | 30,093,632 | [['D09.067.342.531.050'], ['C04.557.470.200.025'], ['A11.251.210.190', 'A11.251.860.180'], ['C04.588.274.476.411.307', 'C06.301.371.411.307', 'C06.405.249.411.307', 'C06.405.469.158.356', 'C06.405.469.491.307', 'C06.405.469.860.180'], ['D05.500.781.750.250', 'D08.811.913.555.500.800.200.500.500.500', 'D12.776.660.235.6... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Cystic neoplasms of the pancreas: results of 114 cases. | OBJECTIVES: To identify clinical, radiographic, and histopathologic characteristics associated with cancer in cystic pancreatic neoplasms and to evaluate our preoperative diagnostic accuracy to predict cancer in such cysts.METHODS: Retrospective case series of 114 patients with cystic lesions of the pancreas who underw... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Diagnosis, Differential', 'Dilatation, Pathologic', 'Female', 'Humans', 'Jaundice', 'Male', 'Middle Aged', 'Pancreas', 'Pancreatic Cyst', 'Pancreatic Ducts', 'Pancreatic Neoplasms', 'Preoperative Period', 'Prognosis', 'Retrospective Studies', 'Sensitivity and Specif... | 20,717,069 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E01.171'], ['C23.300.325'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.429.500', 'C23.888.885.375'], ['M01.060.116.630'], ['A03.734'], ['C04.182.640', 'C06.689.500'], ['A03.734.667'], ['C04.588.274.761', 'C04.588.322.475'... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The variation of the strength of neck extensor muscles and semispinalis capitis muscle size with head and neck position. | Semispinalis capitis muscle (SECM) is a massive and long cervico-thoracic muscle which functions as a main head and neck extensor muscle. The aim of this study was to detect the effect of head and neck positions on the strength of neck extensor muscles and size of SECM in healthy subjects. Thirty healthy women students... | ['Adolescent', 'Cervical Vertebrae', 'Female', 'Head', 'Humans', 'Muscle Strength', 'Neck', 'Neck Muscles', 'Observer Variation', 'Posture', 'Range of Motion, Articular', 'Ultrasonography', 'Young Adult'] | 23,561,867 | [['M01.060.057'], ['A02.835.232.834.151'], ['A01.456'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.600.425', 'G11.427.560'], ['A01.598'], ['A02.633.567.650'], ['E01.354.753', 'N02.421.450.600', 'N05.715.350.150.675', 'N06.850.490.500.250'], ['G11.427.695'], ['E01.370.600.700', 'G11.427.760'], ['E01.370.... | ['Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Mismatched related vs matched unrelated donors in TCRáâ/CD19-depleted HSCT for primary immunodeficiencies. | TCRáâ+/CD19+ graft depletion effectively prevents graft-versus-host disease (GVHD). In the current study, we compared the outcomes of hematopoietic stem cell transplantation (HSCT) with TCRáâ+/CD19+ depletion from matched unrelated donors (MUDs) and mismatched related donors (MMRDs) in patients with primary immunodefic... | ['Adolescent', 'Antigens, CD19', 'Child', 'Child, Preschool', 'Graft Survival', 'Graft vs Host Disease', 'Hematopoietic Stem Cell Transplantation', 'Histocompatibility Testing', 'Humans', 'Immunologic Deficiency Syndromes', 'Infant', 'Prospective Studies', 'Receptors, Antigen, T-Cell, alpha-beta', 'Treatment Outcome', ... | 31,558,465 | [['M01.060.057'], ['D23.050.301.264.035.119', 'D23.050.301.264.051.119', 'D23.050.301.500.600.200', 'D23.050.705.552.600.200', 'D23.101.100.110.119', 'D23.101.100.150.119'], ['M01.060.406'], ['M01.060.406.448'], ['G12.875.545.340'], ['C20.452'], ['E02.095.147.500.500.500', 'E04.936.225.687.500'], ['E01.370.225.812.385'... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Anatomical and histological equivalence of the human, canine, and bull vas deferens. | INTRODUCTION: Several animal models have been utilized for in-vitro experimentation and surgical training exercises of the vas deferens. The canine model is currently the standard for both in-vivo and ex-vivo study. Due to increasing costs associated with experimentation on canines, and in keeping with the principles o... | ['Animals', 'Cattle', 'Cost-Benefit Analysis', 'Dogs', 'Humans', 'Male', 'Models, Animal', 'Species Specificity', 'Urologic Surgical Procedures, Male', 'Vas Deferens', 'Vasovasostomy'] | 21,703,043 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['N03.219.151.125'], ['B01.050.150.900.649.313.750.250.216.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.598'], ['G16.824'], ['E04.950.774.860'], ['A05.360.444.930'], ['E04.035.956', 'E04.950.599.500.800', 'E04.950.774.860.956']] | ['Organisms [B]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Topoisomerase II-dependent and -independent mechanisms of etoposide resistance in Chinese hamster cell lines. | Resistance to etoposide (VP-16), amsacrine (mAMSA), and doxorubicin (Adriamycin) was studied in two Chinese hamster cell lines primarily selected for resistance to the epipodophyllotoxin. Both lines demonstrated profound resistance to VP-16, and mAMSA stimulated DNA breakage. However, the resistance to mAMSA cytotoxici... | ['Amsacrine', 'Animals', 'Cell Line', 'Cell Survival', 'Cricetinae', 'Cricetulus', 'DNA Damage', 'DNA Topoisomerases, Type II', 'Doxorubicin', 'Etoposide'] | 2,535,964 | [['D03.633.300.046.250.225'], ['B01.050'], ['A11.251.210'], ['G04.346'], ['B01.050.150.900.649.313.992.635.075.250'], ['B01.050.150.900.649.313.992.635.075.250.250'], ['G05.200'], ['D08.811.399.403.741'], ['D02.455.426.559.847.562.050.200.175', 'D04.615.562.050.200.175', 'D09.408.051.059.200.175'], ['D02.455.426.559.84... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Radical procedures in patients with pancreatic cancer--impact on prolongation and quality of life]. | INTRODUCTION: In conjunction with adjuvant chemotherapy, radical resections are the only treatment modality, which significantly prolongs survival in pancreatic cancer (CaP) patients. The author aims to define current standards of radical pancreatic resections in CaP patients and to assess benefits of the surgical proc... | ['Chemotherapy, Adjuvant', 'Humans', 'Lymph Node Excision', 'Pancreatectomy', 'Pancreatic Neoplasms', 'Pancreaticoduodenectomy', 'Quality of Life'] | 21,404,511 | [['E02.186.170', 'E02.319.170'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.446'], ['E04.210.752'], ['C04.588.274.761', 'C04.588.322.475', 'C06.301.761', 'C06.689.667', 'C19.344.421'], ['E04.210.760'], ['I01.800', 'K01.752.400.750', 'N06.850.505.400.425.837']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Shikonin inhibits proliferation, migration, invasion and promotes apoptosis in NCI-N87 cells via inhibition of PI3K/AKT signal pathway. | Shikonin has been testified to wield the anti-tumor action in multiple cancers. But, the clout of Shikonin for gastric cancer (GC) is still inconclusive. The contemplation of this research undertook to disclose the impacts of Shikonin on GC progress meanwhile to uncover the conceivable mechanism. NCI-N87 cells were dis... | ['Animals', 'Antineoplastic Agents', 'Apoptosis', 'Cell Line, Tumor', 'Cell Movement', 'Cell Proliferation', 'Cell Survival', 'Down-Regulation', 'Humans', 'Mice', 'MicroRNAs', 'Naphthoquinones', 'Neoplasm Invasiveness', 'Phosphatidylinositol 3-Kinases', 'Proto-Oncogene Proteins c-akt', 'Signal Transduction', 'Stomach N... | 31,257,936 | [['B01.050'], ['D27.505.954.248'], ['G04.146.954.035'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.198', 'G07.568.500.180'], ['G04.161.750', 'G07.345.249.410.750'], ['G04.346'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649.313.992.635.505.5... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Report of 33 novel AVPR2 mutations and analysis of 117 families with X-linked nephrogenic diabetes insipidus. | X-linked nephrogenic diabetes insipidus (NDI) is a rare disease caused by mutations in the arginine vasopressin receptor 2 gene (AVPR2). Thirty-three novel AVPR2 mutations were identified in 62 families that were not included in our previous studies. This study describes the diversity of mutations observed in a total o... | ['Alleles', 'DNA Mutational Analysis', 'Diabetes Insipidus, Nephrogenic', 'Female', 'Genetic Linkage', 'Genotype', 'Haplotypes', 'Humans', 'Incidence', 'Male', 'Mutation', 'Pedigree', 'Polymerase Chain Reaction', 'Quebec', 'Receptors, Vasopressin', 'X Chromosome'] | 10,820,168 | [['G05.360.340.024.340.030'], ['E05.393.760.700.300'], ['C12.777.419.135.500', 'C13.351.968.419.135.500'], ['G05.348'], ['G05.380'], ['G05.380.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.985.525.375'], ['G05.3... | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]', 'Geographicals [Z]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
SCOPA-cognition cutoff value for detection of Parkinson's disease dementia. | The SCOPA-Cognition is a reliable and valid test to evaluate cognitive functioning in Parkinson's disease and is widely used in clinical and research settings. Recently, the Movement Disorder Society introduced criteria for Parkinson's disease dementia. The objective of the present study was to use these criteria to de... | ['Aged', 'Area Under Curve', 'Cognition Disorders', 'Dementia', 'Female', 'Humans', 'Male', 'Mental Status Schedule', 'Middle Aged', 'Neuropsychological Tests', 'Parkinson Disease', 'ROC Curve'] | 21,542,025 | [['M01.060.116.100'], ['E05.318.740.200', 'G03.787.101', 'G07.690.725.064', 'N06.850.520.830.200'], ['F03.615.250'], ['C10.228.140.380', 'F03.615.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F04.711.513.603.500', 'F04.711.513.653.574'], ['M01.060.116.630'], ['F04.711.513'], ['C10.228.140.079.862.500', 'C10... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Predictors of liver-related death among people who inject drugs in Vancouver, Canada: a 15-year prospective cohort study. | INTRODUCTION: While HIV/AIDS remains an important cause of death among people who inject drugs (PWID), the potential mortality burden attributable to hepatitis C virus (HCV) infection among this population is of increasing concern. Therefore, we sought to identify trends in and predictors of liver-related mortality amo... | ['Adult', 'Canada', 'Cohort Studies', 'Female', 'HIV Infections', 'Hepatitis C, Chronic', 'Humans', 'Male', 'Prospective Studies', 'Substance Abuse, Intravenous'] | 25,391,765 | [['M01.060.116'], ['Z01.107.567.176'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['C01.221.250.750.120', 'C01.925.440.440.120', 'C01.925.782.350.350.120', 'C06... | ['Named Groups [M]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Novel mutation in C10orf2 associated with multiple mtDNA deletions, chronic progressive external ophthalmoplegia and premature aging. | Chronic progressive external ophthalmoplegia (CPEO) is caused by defects in both mitochondrial and nuclear genes, however, the causal genetic factors in large number of patients remains undetermined. Therefore, our aim was to screen 12 unrelated patients with CPEO for mutation/multiple deletions in mtDNA and mutations ... | ['Adult', 'Aging, Premature', 'Base Sequence', 'DNA Helicases', 'DNA, Mitochondrial', 'Humans', 'Male', 'Mitochondrial Proteins', 'Ophthalmoplegia, Chronic Progressive External', 'Point Mutation', 'Sequence Deletion'] | 26,689,116 | [['M01.060.116'], ['C23.888.069'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D08.811.277.040.025.159', 'D08.811.399.340'], ['D13.444.308.283.225'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.575'], ['C05.651.460.700', 'C10.292.562.750.250', 'C10.597.622.447.511', 'C10.668.491.500.700'... | ['Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Monolayers of a tetrazine-containing gemini amphiphile: Interplays with biomembrane lipids. | The property of a newly synthesized tetrazine derivative comprised of double C18-saturated hydrocarbon chain (C18-rTz-C18) has been studied in situ at the air-water interface. C18-rTz-C18 or a gemini amphiphile contributes to restriction of its tetrazine moiety on the interface, which is expected to be used for bioimag... | ['1,2-Dipalmitoylphosphatidylcholine', 'Heterocyclic Compounds, 1-Ring', 'Membrane Lipids', 'Microscopy, Atomic Force', 'Surface-Active Agents', 'Temperature', 'Thermodynamics'] | 29,353,162 | [['D10.570.755.375.760.400.800.224'], ['D03.383'], ['D10.570'], ['E01.370.350.515.666.400', 'E05.595.666.400'], ['D27.720.877'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.150.450', 'N06.230.300.100.725.710'], ['G01.906']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Effects of grapefruit juice and smoking on verapamil concentrations in steady state. | OBJECTIVE: Human gut wall cytochrome P(450) (CYP)3A4 is inhibited by grapefruit juice (G), whereas smoking increases CYP1A2 activity. Both enzymes contribute to verapamil biotransformation. This study was performed to quantitatively assess the effect of these factors on verapamil pharmacokinetics in steady state.METHOD... | ['Adult', 'Beverages', 'Calcium Channel Blockers', 'Chromatography, High Pressure Liquid', 'Citrus', 'Cross-Over Studies', 'Cytochrome P-450 CYP1A2', 'Cytochrome P-450 CYP3A', 'Cytochrome P-450 Enzyme System', 'Female', 'Flavanones', 'Flavonoids', 'Food-Drug Interactions', 'Humans', 'Hydrocortisone', 'Male', 'Mixed Fun... | 11,956,673 | [['M01.060.116'], ['G07.203.100', 'J02.200'], ['D27.505.519.562.249', 'D27.505.696.260.500', 'D27.505.954.411.192'], ['E05.196.181.400.300'], ['B01.650.940.800.575.912.250.875.177'], ['E05.318.370.150', 'N05.715.360.325.150', 'N06.850.520.445.150'], ['D08.244.453.005.443', 'D08.244.453.100.750', 'D08.811.682.690.708.17... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
PNT2258, a novel deoxyribonucleic acid inhibitor, induces cell cycle arrest and apoptosis via a distinct mechanism of action: a new class of drug for non-Hodgkin's lymphoma. | Current therapy for BCL-2-associated tumors such as Non-Hodgkin Lymphomas (NHL) is inadequate. The DNAi PNT2258, a 24 base single-stranded phosphodiester DNA oligodeoxynucleotide (PNT100) encapsulated in a protective liposome, was precisely designed to treat cancers that over-express BCL-2. PNT2258 strongly inhibited B... | ['Apoptosis', 'Caspase 3', 'Cell Cycle Checkpoints', 'Cell Line, Tumor', 'Cell Survival', 'Gene Expression Regulation, Neoplastic', 'Gene Silencing', 'Humans', 'Liposomes', 'Lymphoma, Non-Hodgkin', 'Oligodeoxyribonucleotides', 'Promoter Regions, Genetic', 'Proto-Oncogene Proteins c-bcl-2', 'RNA, Messenger', 'S Phase', ... | 27,283,896 | [['G04.146.954.035'], ['D08.811.277.656.262.500.126.350.300', 'D08.811.277.656.300.200.126.350.300', 'D12.644.360.075.405.350.300', 'D12.776.476.075.405.350.300'], ['G04.144.109'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.346'], ['G05.308.370'], ['G05.308.203.374'], ['B01.050.150.900.649.313.988.400.112.400.400'],... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Sequential renal alterations in septic shock in the primate. | This is a descriptive sequential study of the response of the baboon to LD100 Escherichia coli. The response was found to consist of three stages based on electron microscopic, physiologic, and clinical laboratory data. This study associates the inflammatory, coagulant, and cell injury (stage 1-3) responses with marker... | ['Animals', 'Capillaries', 'Edema', 'Endothelium, Vascular', 'Escherichia coli Infections', 'Kidney', 'Kidney Tubules', 'Leukocytes', 'Microscopy, Electron', 'Microscopy, Electron, Scanning', 'Necrosis', 'Papio', 'Shock, Septic', 'Tissue Plasminogen Activator', 'Tumor Necrosis Factor-alpha'] | 1,904,322 | [['B01.050'], ['A07.015.461.165'], ['C23.888.277'], ['A07.015.700.500', 'A10.272.491.355'], ['C01.150.252.400.310.330'], ['A05.810.453'], ['A05.810.453.736.560'], ['A11.118.637', 'A15.145.229.637', 'A15.382.490'], ['E01.370.350.515.402', 'E05.595.402'], ['E01.370.350.515.402.541', 'E05.595.402.541'], ['C23.550.717'], [... | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Two bioluminescent diptera: the North American Orfelia fultoni and the Australian Arachnocampa flava. Similar niche, different bioluminescence systems. | Orfelia fultoni is the only bioluminescent dipteran (Mycetophilidae) found in North America. Its larvae live on stream banks in the Appalachian Mountains. Like their Australasian relative Arachnocampa spp., they build sticky webs to which their bioluminescence attracts flying prey. They bear two translucent lanterns at... | ['Adenosine Triphosphate', 'Animals', 'Ascorbic Acid', 'Australia', 'Diptera', 'Dithiothreitol', 'Environment', 'Firefly Luciferin', 'Luciferases', 'Luminescence', 'North America', 'Photobiology', 'Species Specificity'] | 11,837,324 | [['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['B01.050'], ['D02.241.081.844.107', 'D02.241.511.902.107', 'D09.811.100'], ['Z01.639.100', 'Z01.678.100.373'], ['B01.050.500.131.617.720.500.500.750'], ['D02.033.800.196', 'D02.886.740.224', 'D09.853.196'], ['G16.500.275', 'N06.230'], ['D0... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
Expression, activation and clinical relevance of CHK1 and CHK2 in metastatic high-grade serous carcinoma. | OBJECTIVE: To analyze the expression and clinical role of CHK1 and CHK2 in metastatic high-grade serous carcinoma (HGSC).METHODS: HGSC effusions (n = 335; 280 peritoneal, 55 pleural) were analyzed for protein expression of total CHK1 and its phosphorylated forms p-ser317 and p-ser296, as well as total CHK2 and its phos... | ['Adult', 'Aged', 'Aged, 80 and over', 'Checkpoint Kinase 1', 'Checkpoint Kinase 2', 'Cystadenocarcinoma, Serous', 'Enzyme Activation', 'Female', 'Humans', 'Middle Aged', 'Neoplasm Grading', 'Survival Analysis', 'Young Adult'] | 29,804,637 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D08.811.913.696.620.682.700.143'], ['D08.811.913.696.620.682.700.145'], ['C04.557.470.200.025.480.240', 'C04.557.470.590.480.240'], ['G02.111.263', 'G03.328'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.789.612'], ['E05.3... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Prospective individual and social predictors of changes in adjustment for patients attending a regional cancer service. | PURPOSE: This study applied the social-cognitive processing (SCP) model to examine whether positive (social support) and negative (social constraints) aspects of the social environment influenced emotional distress, quality of life (QoL), well-being, and benefit finding after cancer.METHODS: Participants were 439 adult... | ['Adaptation, Psychological', 'Adult', 'Aged', 'Aged, 80 and over', 'Anxiety', 'Australia', 'Depression', 'Female', 'Humans', 'Interviews as Topic', 'Male', 'Middle Aged', 'Neoplasms', 'Outcome Assessment, Health Care', 'Prospective Studies', 'Psychiatric Status Rating Scales', 'Quality of Life', 'Sick Role', 'Social A... | 22,653,685 | [['F01.058'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['F01.470.132'], ['Z01.639.100', 'Z01.678.100.373'], ['F01.145.126.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.420', 'L01.399.250.520', 'N05.715.360.300.400', 'N06.850.520.308.420'], ['M01.060.116.630'], ['C04'], ['H0... | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Geographicals [Z]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]', 'Diseases [C]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [... | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
[Isoelectric heterogeneity and oxygen affinity of chicken hemoglobin, depending on age]. | Differences in the isoelectric spectra and in the molecular oxygen affinity to hemoglobin have been shown in 14-, 28- and 49-day hens. A regular decrease in the number of isoelectric components as well as a deterioration of the hemoglobin affinity to oxygen in 49-day hens have been observed. | ['Aging', 'Animals', 'Chickens', 'Female', 'Hemoglobins', 'Hydrogen-Ion Concentration', 'Isoelectric Focusing', 'Oxygen'] | 2,270,630 | [['G07.345.124'], ['B01.050'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['D12.776.124.400', 'D12.776.422.316.762'], ['G02.300'], ['E05.196.401.663', 'E05.301.300.663'], ['D01.268.185.550', 'D01.362.670']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Gastric emptying: influence of prolonged exercise and carbohydrate concentration. | Gastric emptying: influence of prolonged exercise and carbohydrate concentration, Med. Sci. Sports Exerc., Vol. 21, No. 3, pp. 269-274, 1989. The purpose of this study was to examine the effects of serial feedings of different concentrations of carbohydrate (CHO) on gastric emptying and to compare the rates of gastric ... | ['Adult', 'Bicycling', 'Dietary Carbohydrates', 'Exercise', 'Fructose', 'Gastric Emptying', 'Glucose', 'Humans', 'Male', 'Sucrose', 'Water-Electrolyte Balance'] | 2,733,575 | [['M01.060.116'], ['I03.450.642.845.140'], ['D09.301', 'G07.203.300.362', 'J02.500.362'], ['G11.427.410.698.277', 'I03.350'], ['D09.947.875.359.250', 'D09.947.875.465.354'], ['G10.261.360.400'], ['D09.947.875.359.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D09.698.629.305.770', 'D09.947.750.770'], ['G02.1... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 |
Staphylococcal superantigen-like protein 10 binds to phosphatidylserine and apoptotic cells. | Staphylococcal superantigen-like proteins (SSLs) are a family of exoproteins that have structural similarities to staphylococcal superantigens. Although SSLs do not have superantigenic activity, some of them have been reported to bind to host immune related molecules and they have been implicated in immune evasion by S... | ['Apoptosis', 'Bacterial Proteins', 'Humans', 'Jurkat Cells', 'Liposomes', 'Phosphatidylserines', 'Protein Binding', 'Staphylococcus aureus', 'Superantigens'] | 22,486,378 | [['G04.146.954.035'], ['D12.776.097'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.251.210.190.495', 'A11.251.860.180.495', 'A15.382.490.555.567.569.440'], ['D25.479.517', 'D26.255.260.517', 'J01.637.051.479.517', 'J01.637.087.500.517'], ['D10.570.755.375.760.400.971'], ['G02.111.679', 'G03.808'], ['B03.300.... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
The closure of the gingival crevice following gingival retraction for impression making. | Scant attention has been paid to the effectiveness of chemomechanical displacement of the gingiva prior to impression making for fixed partial dentures. The closure of the gingival crevice following removal of medicated retraction cord was observed using a miniature video camera. Sulcular widths were measured at time i... | ['Adult', 'Analysis of Variance', 'Animals', 'Bombyx', 'Dental Impression Technique', 'Denture, Partial, Fixed', 'Equipment Design', 'Female', 'Gingiva', 'Humans', 'Insect Proteins', 'Male', 'Middle Aged', 'Reproducibility of Results', 'Silk', 'Textiles', 'Time Factors', 'Videotape Recording'] | 9,357,742 | [['M01.060.116'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['B01.050'], ['B01.050.500.131.617.720.500.500.937.650.100'], ['E06.912.130'], ['E06.780.346.760.943.271', 'E07.695.190.200.220.220'], ['E05.320'], ['A14.549.167.646.480'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.093... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Information Science [L]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 0 |
Deep brain stimulation of the subthalamic nucleus facilitates coordination of hand preshaping in Parkinson's disease. | Several studies have found that Parkinson's disease (PD) disrupts the organization of complex motor sequences regardless of the influence of parkinsonian medications. A clear candidate for the neural bases of such deficits, which we term "coordinative," is the failure to integrate propioceptive and visual information b... | ['Aged', 'Aged, 80 and over', 'Analysis of Variance', 'Biomechanical Phenomena', 'Case-Control Studies', 'Deep Brain Stimulation', 'Female', 'Humans', 'Male', 'Mental Status Schedule', 'Parkinson Disease', 'Psychomotor Performance', 'Reaction Time', 'Statistics as Topic', 'Subthalamic Nucleus'] | 19,922,392 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['G01.154.090', 'G01.374.089'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['E02.331.300', 'E04.190'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F04.711.513.603.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Disciplines and Occupations [H]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Results of positive proximal margin after resection for hilar cholangiocarcinoma: An analysis of 42 cases. | BACKGROUND/AIMS: Hilar cholangiocarcinoma (HC) is a tumor that invades the confluence of the left and right hepatic bile ducts. Surgery is the definitive treatment but is also technically demanding. Here, we report our experience on 42 patients who underwent surgical resection for HC. The aim of the present study was t... | ['Aged', 'Bile Duct Neoplasms', 'Bile Ducts, Intrahepatic', 'Female', 'Frozen Sections', 'Hepatectomy', 'Humans', 'Klatskin Tumor', 'Male', 'Margins of Excision', 'Middle Aged', 'Retrospective Studies', 'Survival Rate', 'Treatment Outcome'] | 30,301,710 | [['M01.060.116.100'], ['C04.588.274.120.250', 'C06.130.120.120', 'C06.130.320.120', 'C06.301.120.250'], ['A03.159.183.158', 'A03.620.150'], ['E01.370.225.500.620.530.160.260', 'E01.370.225.750.600.530.160.260', 'E05.200.500.620.530.160.260', 'E05.200.750.600.530.160.260'], ['E04.210.556'], ['B01.050.150.900.649.313.988... | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Catheter ablation of atrial fibrillation in patients with heart failure: impact of maintaining sinus rhythm on heart failure status and long-term rates of stroke and death. | AIMS: Catheter ablation of atrial fibrillation (AF) in patients with heart failure (HF) can improve left ventricular (LV) function and HF symptoms. We aimed to investigate whether long-term maintenance of sinus rhythm impacts on hard outcomes such as stroke and death.METHODS AND RESULTS: An international multicentre re... | ['Aged', 'Anti-Arrhythmia Agents', 'Atrial Fibrillation', 'Australia', 'Catheter Ablation', 'Female', 'Heart Failure', 'Humans', 'Male', 'Middle Aged', 'Multivariate Analysis', 'Perioperative Period', 'Recurrence', 'Registries', 'Stroke', 'Stroke Volume', 'Survival Analysis', 'Treatment Outcome', 'United Kingdom', 'Ven... | 26,843,584 | [['M01.060.116.100'], ['D27.505.954.411.097'], ['C14.280.067.198', 'C23.550.073.198'], ['Z01.639.100', 'Z01.678.100.373'], ['E02.808.750.500', 'E04.014.760.500'], ['C14.280.434'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.740.150.500', 'N05.715.360.750.125.500', 'N06.850.520.830.15... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Formulation and evaluation of verapamil hydrochloride loaded solid lipid microparticles. | The present study aimed to produce verapamil hydrochloride-loaded solid lipid microparticles (SLM) by the w/o/w emulsion solvent evaporation technique, using diethyl ether as solvent phase, glyceryl monostearate as biodegradable polymer and Span 60 as surfactant. SLM of spherical shape were prepared by simple dilution ... | ['Acids', 'Calcium Channel Blockers', 'Calorimetry, Differential Scanning', 'Chemistry, Pharmaceutical', 'Drug Stability', 'Emulsions', 'Glycerol', 'Hydrogen-Ion Concentration', 'Lipids', 'Materials Testing', 'Microscopy, Electron, Scanning', 'Microspheres', 'Monoglycerides', 'Particle Size', 'Stearates', 'Sterilizatio... | 21,391,431 | [['D01.029'], ['D27.505.519.562.249', 'D27.505.696.260.500', 'D27.505.954.411.192'], ['E05.196.131.310', 'E05.196.370.310'], ['H01.158.703.007', 'H01.181.466'], ['E05.916.330'], ['D20.280.260', 'D26.255.165.260'], ['D02.033.800.875.500', 'D09.853.875.500'], ['G02.300'], ['D10'], ['E05.570'], ['E01.370.350.515.402.541',... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Local effects of cannabinoids on spontaneous activity and evoked inhibition in the globus pallidus. | The globus pallidus has been identified as a site of action for the motor effects of cannabinoids. A previous report from this laboratory demonstrated that systemic administration of the potent and selective cannabinoid receptor agonist (R)-(+)-[2,3-dihydro-5-methyl-3-[(4-morpholinyl) methyl]pyrrolo[1,2,3-de]-1,4-benzo... | ['Animals', 'Benzoxazines', 'Cannabinoids', 'Cyclohexanols', 'Evoked Potentials', 'Globus Pallidus', 'Male', 'Morpholines', 'Motor Activity', 'Naphthalenes', 'Rats', 'Rats, Sprague-Dawley'] | 9,716,355 | [['B01.050'], ['D03.383.533.249', 'D03.633.100.209'], ['D02.455.849.090'], ['D02.033.415.510.500', 'D02.455.426.392.368.367.318', 'D10.289.510.500'], ['G07.265.216.500', 'G11.561.200.500'], ['A08.186.211.200.885.287.249.487.397'], ['D03.383.533.640'], ['F01.145.632', 'G11.427.410.698'], ['D02.455.426.559.847.638', 'D04... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Key success factors for thoracic endovascular aortic repair for non-acute Stanford type B aortic dissection. | OBJECTIVES: We aimed to determine the key factors associated with successful early and late outcomes after thoracic endovascular aortic repair (TEVAR) for non-acute Stanford type B aortic dissection at our institution.METHODS: Inpatient and outpatient records were retrospectively reviewed. Patients operated on within 1... | ['Adult', 'Aged', 'Aneurysm, Dissecting', 'Aortic Aneurysm, Thoracic', 'Blood Vessel Prosthesis Implantation', 'Endovascular Procedures', 'Female', 'Humans', 'Kaplan-Meier Estimate', 'Male', 'Middle Aged', 'Retrospective Studies', 'Tomography, X-Ray Computed', 'Young Adult'] | 24,554,070 | [['M01.060.116'], ['M01.060.116.100'], ['C14.907.055.050'], ['C14.907.055.239.125', 'C14.907.109.139.125'], ['E04.100.814.868.500', 'E04.650.200'], ['E04.100.814.529', 'E04.502.382'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.998.650', 'N05.715.360.750.795.650', 'N06.850.520.830.998.650'], ['M01.06... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Collaborative Dental Hygiene Practice in New Mexico and Minnesota. | PURPOSE: This descriptive, comparative study was conducted to examine characteristics, services, models and opinions among collaborative dental hygiene practitioners in New Mexico and Minnesota.METHODS: A self-designed online questionnaire, distributed via SurveyMonkey®, was utilized to collect data from 73 subjects wh... | ['Adult', 'Dental Care', 'Dental Hygienists', 'Female', 'Health Services Accessibility', 'Healthcare Disparities', 'Humans', 'Independent Practice Associations', 'Medicaid', 'Middle Aged', 'Minnesota', 'New Mexico', 'Oral Hygiene', 'Reproducibility of Results', 'Surveys and Questionnaires', 'United States', 'Young Adul... | 27,340,181 | [['M01.060.116'], ['E06.170', 'N02.421.240.190'], ['M01.526.485.067.105.376', 'N02.360.067.105.376'], ['N04.590.374.350', 'N05.300.430'], ['N04.590.374.380', 'N05.300.493'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.219.521.576.343.800.450', 'N04.452.758.244.450', 'N04.452.758.745.450', 'N04.590.374.410.45... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Molecular cloning, expression analysis and characterization of peroxiredoxin during WSSV infection in shrimp Fenneropenaeus indicus. | Innate immunity is the first line of defense in shrimps against invading pathogenic microorganisms. Peroxiredoxins (PRX) are the family of antioxidant proteins that play a crucial role in reduction of oxidative stress in host during viral infection. Peroxiredoxin from Fenneropenaeus indicus was identified, cloned and e... | ['Amino Acid Sequence', 'Animals', 'Antioxidants', 'Base Sequence', 'Cloning, Molecular', 'DNA Virus Infections', 'Dithiothreitol', 'Evolution, Molecular', 'Gene Expression', 'Gills', 'Heart', 'Hemocytes', 'Insulin', 'Molecular Sequence Data', 'Muscle, Skeletal', 'Myocardium', 'Oxidation-Reduction', 'Penaeidae', 'Perox... | 21,964,313 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.393.220'], ['C01.925.256'], ['D02.033.800.196', 'D02.886.740.224', 'D09.853.196'], ['G05.045.250', 'G16.075.250'], ['G05.297'], ['A13.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Nucleotide sequence divergence of mouse immunoglobulin gamma 1 and gamma 2b chain genes and the hypothesis of intervening sequence-mediated domain transfer. | The nucleotide sequences of the constant portions of mouse immunoglobulin gamma 1 and gamma 2b genes were compared. A remarkable homology was found in a long (about 500 nucleotides) continuous segment including the entire CH1 coding region and about the first half of the first intervening sequence. Furthermore, compari... | ['Amino Acid Sequence', 'Animals', 'Base Sequence', 'Biological Evolution', 'Codon', 'Crossing Over, Genetic', 'Immunoglobulin Heavy Chains', 'Immunoglobulin gamma-Chains', 'Mice'] | 6,769,121 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G05.045', 'G16.075'], ['D13.444.735.544.355', 'G05.360.335.355', 'G05.360.340.024.340.137.190'], ['G05.728.615.200'], ['D12.776.124.486.485.705.500', 'D12.776.124.790.651.705.500', 'D12.776.377.715.548... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
[Rickettsies and pararickettsies. Technique and results of microagglutination. Importance of reactivation (author's transl)]. | After briefly summarizing the chacteristics of all infections caused by rickettsies and pararickettsies, which are the same depending on the same properties of these pathogen agents, the Author describes the microagglutination technique which is the elective method of serodiagnosis, briefly referring the genesis. The A... | ['Agglutination Tests', 'Humans', 'Rickettsia', 'Serologic Tests'] | 555,260 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Stimulation electromyography as a method of intraoperative localization and identification of the facial nerve during parotidectomy: review of 15 consecutive parotid surgeries. | INTRODUCTION: It has been widely recognized that one of the major hazards during operation of the parotid gland, mainly in tumor resection, is the injury of the facial nerve. Facial nerve monitoring has achieved wide application in otologic and neurotologic procedures to help localization and protection of the facal ne... | ['Electric Stimulation', 'Electromyography', 'Facial Nerve', 'Facial Nerve Injuries', 'Humans', 'Intraoperative Complications', 'Monitoring, Intraoperative', 'Parotid Gland', 'Surgical Procedures, Operative'] | 12,087,949 | [['E05.723.402'], ['E01.370.405.255', 'E01.370.530.255'], ['A08.800.050.050.275', 'A08.800.050.600.149', 'A08.800.800.060.275', 'A08.800.800.120.250'], ['C07.465.299.500', 'C10.292.200.500', 'C10.292.319.500', 'C10.900.300.218.300', 'C26.915.300.400.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.505'... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Biaryls and heterobiaryls as alpha-glucosidase and protein tyrosine phosphatase inhibitors. | Various 6-aryl-4-substituted-2H-pyran-2-one-3-carbonitriles (1a-d) have been synthesized as precursor for the synthesis of 3,4-dihydro-1H-isothiochroman (2a) and benzocycloalkanes (2b-e). Highly functionalized 9-thiaphenanthrene (3b) and phenanthrene (3a) have also been obtained from the reaction of 1c with thiochroman... | ['Enzyme Inhibitors', 'Glycoside Hydrolase Inhibitors', 'Hydrocarbons, Aromatic', 'Molecular Structure', 'Protein Tyrosine Phosphatases', 'Structure-Activity Relationship'] | 15,713,383 | [['D27.505.519.389'], ['D27.505.519.389.320', 'D27.505.696.422.249'], ['D02.455.426.559'], ['G02.111.570', 'G02.466'], ['D08.811.277.352.650.775'], ['G02.111.830', 'G07.690.773.997']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effect of background colors on the tuning of color-selective cells in monkey area V4. | When objects are viewed in different illuminants, their color does not change or changes little in spite of significant changes in the wavelength composition of the light reflected from them. In previous studies, we have addressed the physiology underlying this color constancy by recording from cells in areas V1, V2, a... | ['Action Potentials', 'Analysis of Variance', 'Animals', 'Brain Mapping', 'Color', 'Color Perception', 'Macaca fascicularis', 'Male', 'Neurons', 'Photic Stimulation', 'Sensory Thresholds', 'Visual Cortex', 'Visual Fields', 'Wakefulness'] | 16,617,176 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['B01.050'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['G01.590.540.199'], ['F02.463.593.932.217'], ['B01.050.150.900.649.313.988.400.112.199.120.510.520'], ['A08.... | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Myotonia, a new inherited muscle disease in mice. | Electromyographic (EMG) and histological studies were carried out with the new mouse mutant myotonia (mto, autosomal recessive). Affected animals exhibited behavioral myotonia which was apparent at 2 weeks of age. EMG studies revealed myotonic discharges (prolonged repetitive discharges with recurrent variation in ampl... | ['Animals', 'Crosses, Genetic', 'Disease Models, Animal', 'Electromyography', 'Genetic Linkage', 'Heterozygote', 'Homozygote', 'Mice', 'Mice, Neurologic Mutants', 'Muscles', 'Myotonia Congenita'] | 7,097,320 | [['B01.050'], ['E05.393.281'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['E01.370.405.255', 'E01.370.530.255'], ['G05.348'], ['G05.380.383'], ['G05.380.554'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.150.900.649.313.992.635.505.500.550.480'], ['A02.633', 'A10.690'], ['C05.651.662.500', 'C10.574.500.... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Blood group isoantigen expression during tumour progression of cervical neoplasia. | Twenty-nine cases of microinvasive squamous and 38 cases of progression from preinvasive to invasive carcinoma of the cervix were immunostained with monoclonal antibodies against blood group isoantigens for expression in normal, dysplastic and neoplastic epithelium. The results show a varying staining pattern without c... | ['ABO Blood-Group System', 'Adult', 'Age Factors', 'Aged', 'Aged, 80 and over', 'Female', 'Humans', 'Isoantigens', 'Middle Aged', 'Neoplasm Invasiveness', 'Uterine Cervical Neoplasms'] | 3,442,419 | [['D23.050.301.290.031', 'D23.050.705.230.031'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D23.050.705'], ['M01.060.116.630'], ['C04.697.645', 'C23.550.727.645'], ['C04.588.945.418.948.850', 'C13.351.500.852.... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Influence of hyperbaric oxygen on left ventricular contractility, total coronary blood flow, and myocardial oxygen consumption in the conscious dog. | It is known that hyperbaric oxygenation (HBO) decreases total coronary blood flow (TCBF) and cardiac output (CO). To determine whether this is related to an alteration in myocardial contractility, 10 chronically instrumented conscious dogs were studied during pharmacologic autonomic blockade. Left ventricular (LV) volu... | ['Animals', 'Cardiac Output', 'Coronary Circulation', 'Dogs', 'Hyperbaric Oxygenation', 'Myocardial Contraction', 'Myocardium', 'Oxygen Consumption', 'Stroke Volume', 'Ventricular Function, Right'] | 8,061,558 | [['B01.050'], ['E01.370.370.380.150', 'G09.330.380.124'], ['G09.330.100.324'], ['B01.050.150.900.649.313.750.250.216.200'], ['E02.880.690.490'], ['G09.330.580', 'G11.427.494.570'], ['A02.633.580', 'A07.541.704', 'A10.690.552.750'], ['G03.680'], ['E01.370.370.380.150.700', 'G09.330.380.124.882'], ['G09.330.955.900']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Spatiotemporal Bayesian inference dipole analysis for MEG neuroimaging data. | Recently, we described a Bayesian inference approach to the MEG/EEG inverse problem that used numerical techniques to estimate the full posterior probability distributions of likely solutions upon which all inferences were based [Schmidt, D.M., George, J.S., Wood, C.C., 1999. Bayesian inference applied to the electroma... | ['Algorithms', 'Bayes Theorem', 'Data Interpretation, Statistical', 'Diagnostic Imaging', 'Electric Stimulation', 'Electroencephalography', 'Evoked Potentials', 'Humans', 'Magnetoencephalography', 'Markov Chains', 'Median Nerve', 'Models, Statistical', 'Monte Carlo Method', 'Poisson Distribution', 'Time Factors'] | 16,023,866 | [['G17.035', 'L01.224.050'], ['E05.318.740.600.200', 'N05.715.360.750.625.150', 'N06.850.520.830.600.200'], ['E05.245.380', 'E05.318.740.300', 'L01.313.500.750.190.380', 'N05.715.360.750.300', 'N06.850.520.830.300'], ['E01.370.350'], ['E05.723.402'], ['E01.370.376.300', 'E01.370.405.245'], ['G07.265.216.500', 'G11.561.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Progression of coronary artery disease in patients with chest pain and normal or intraluminal disease on arteriography. | The incidence of progression of coronary artery disease (CAD) in symptomatic patients was determined from serial coronary arteriograms in 27 patients with normal coronary arteries on initial study, in 17 patients with intraluminal disease (narrowings less than or equal to 20%) (ILD), and in 125 patients with occlusive ... | ['Adult', 'Arterial Occlusive Diseases', 'Coronary Angiography', 'Coronary Disease', 'Coronary Vessels', 'Female', 'Humans', 'Male', 'Middle Aged', 'Pain', 'Radiography, Thoracic'] | 6,691,239 | [['M01.060.116'], ['C14.907.137'], ['E01.370.350.130.625', 'E01.370.350.700.060.200', 'E01.370.370.050.200', 'E01.370.370.380.200'], ['C14.280.647.250', 'C14.907.585.250'], ['A07.015.114.269', 'A07.015.908.194'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C23.888.592.612', 'F02.830.816.444'... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Mosaicism of XX and XXY cells accounts for high copy number of Toll like Receptor 7 and 8 genes in peripheral blood of men with Rheumatoid Arthritis. | The X chromosome, hemizygous in males, contains numerous genes important to immunological and hormonal function. Alterations in X-linked gene dosage are suspected to contribute to female predominance in autoimmunity. A powerful example of X-linked dosage involvement comes from the BXSB murine lupus model, where the dup... | ['Arthritis, Rheumatoid', 'Case-Control Studies', 'Chromosomes, Human, X', 'Chromosomes, Human, Y', 'Gene Dosage', 'Humans', 'Male', 'Mosaicism', 'RNA, Messenger', 'Signal Transduction', 'Toll-Like Receptor 7', 'Toll-Like Receptor 8'] | 31,501,466 | [['C05.550.114.154', 'C05.799.114', 'C17.300.775.099', 'C20.111.199'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['A11.284.187.520.300.325.680', 'A11.284.187.865.982.500', 'G05.360.162.520.300.325.680', 'G05.360.162.865.982.500'], ['A11.284.187.520.300.505.757', 'A11.284.187.865.983... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Effects of methylated derivatives of Luteolin isolated from Cyperus alopecuroides in rat H4IIE hepatoma cells*. | Polyphenols are ubiquitous substances in human diet. Their antioxidative, antiinflammatory and antiviral effects are of interest for human health, and polyphenols such as luteolin are used at high concentrations in food supplements. Luteolin is metabolized to glucuronides, but also to methylated derivatives. For exampl... | ['Animals', 'Apoptosis', 'Carcinoma, Hepatocellular', 'Cell Line, Tumor', 'Cell Survival', 'Cyperus', 'Flowers', 'Free Radical Scavengers', 'Luteolin', 'Methylation', 'Rats'] | 16,445,590 | [['B01.050'], ['G04.146.954.035'], ['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.346'], ['B01.650.940.800.575.912.250.312.199'], ['A18.024.249.500'], ['D27.505.519.217.500'], ['D03.383.663.283.266.450.260.555', 'D03.633.100.150.26... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Major methylation alterations on the CpG markers of inflammatory immune associated genes after IVIG treatment in Kawasaki disease. | BACKGROUND: Kawasaki disease (KD) is an autoimmune disease preferentially attacking children younger than five years worldwide. So far, the principal treatment to KD is the administration of Intravenous immunoglobulin (IVIG). Although DNA methylation plays important regulation roles in diseases, few studies investigate... | ['Case-Control Studies', 'CpG Islands', 'DNA Methylation', 'Genetic Markers', 'Humans', 'Immunoglobulins, Intravenous', 'Inflammation', 'Mucocutaneous Lymph Node Syndrome', 'Transcriptome'] | 27,534,746 | [['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['G02.111.570.080.380.160', 'G05.360.080.380.160', 'G05.360.340.024.159'], ['G02.111.035.538.161', 'G02.111.218', 'G03.059.538.161', 'G05.206'], ['D23.101.387', 'G05.695.450'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.124.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Neither Deep nor Shallow: A Classroom Experiment Testing the Orthographic Depth of Tone Marking in Kabiye (Togo). | The experiment reported here tests the Lexical Orthography Hypothesis, that is, the notion that the output of the lexical phonology is the most promising phonological depth for an exhaustive representation of tone by means of diacritics in the orthography of atone language. We conducted a controlled classroom experimen... | ['Adolescent', 'Female', 'Humans', 'Linguistics', 'Male', 'Multilingualism', 'Phonetics', 'Psycholinguistics', 'Speech Acoustics', 'Togo', 'Verbal Learning', 'Writing'] | 27,089,808 | [['M01.060.057'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.559.598'], ['L01.559.423.452'], ['L01.559.598.518'], ['F02.694', 'F04.096.586', 'L01.559.598.628'], ['G11.561.812.650', 'G11.561.820'], ['Z01.058.290.190.800'], ['F02.463.425.952'], ['L01.559.423.906']] | ['Named Groups [M]', 'Organisms [B]', 'Information Science [L]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 |
Numb regulates acinar cell dedifferentiation and survival during pancreatic damage and acinar-to-ductal metaplasia. | BACKGROUND & AIMS: Pancreatic ductal adenocarcinoma (PDA) is a leading cause of cancer-related death. Through the process of acinar-to-ductal metaplasia (ADM), pancreatic acinar cells give rise to pancreatic intraepithelial neoplasia (PanIN), the most common precursor of PDA. However, even when Kras is activated in a m... | ['Acinar Cells', 'Animals', 'Apoptosis', 'Cell Dedifferentiation', 'Cell Survival', 'Ceruletide', 'Disease Models, Animal', 'Membrane Proteins', 'Metaplasia', 'Mice', 'Mice, Inbred Strains', 'Nerve Tissue Proteins', 'Pancreas', 'Pancreatic Ducts', 'Pancreatitis', 'Proto-Oncogene Proteins p21(ras)', 'Regeneration', 'Sig... | 23,891,977 | [['A11.031'], ['B01.050'], ['G04.146.954.035'], ['G04.148'], ['G04.346'], ['D12.644.456.241'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['D12.776.543'], ['C23.550.589'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520', 'B01.050.150.900.649.313.992.635.505.500.400'], ['D12.776.631'], ['A03.... | ['Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Exploring motorcycle red-light violation in response to pedestrian green signal countdown device. | Literature has suggested that angle/rear-end collisions would arise from the reality that motorists and motorcyclists tended to accelerate aggressively in response to the remaining seconds of green signal countdown device (GSCD). One safety concern, while GSCD has gradually been removed for safety in Taiwan, is pedestr... | ['Accident Prevention', 'Accidents, Traffic', 'Environmental Exposure', 'Head Protective Devices', 'Humans', 'Logistic Models', 'Male', 'Motorcycles', 'Pedestrians', 'Taiwan'] | 25,460,099 | [['N06.850.135.060'], ['N06.850.135.392'], ['N06.850.460.350'], ['E07.700.380', 'J01.637.708.560.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.525', 'E05.318.740.600.800.450', 'E05.318.740.750.450', 'E05.599.835.875', 'N05.715.360.750.530.480', 'N05.715.360.750.625.700.450', 'N05.715.360.750... | ['Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Named Groups [M]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
Transformation of ginsenosides Rb1 and Re from Panax ginseng by food microorganisms. | Ginsenosides Rb1 and Re, respectively belonging to the major protopanaxadiol and protopanaxatriol ginsenosides, were transformed using cell-free extracts from food microorganisms. Rb1 was transformed into compound K via Rd and F2 by Bifidobacterium sp. Int57, Bif. sp. SJ32, Aspergillus niger and A. usamii. Lactobacillu... | ['Aspergillus', 'Aspergillus niger', 'Bifidobacterium', 'Chromatography, High Pressure Liquid', 'Chromatography, Thin Layer', 'Enzymes', 'Food Microbiology', 'Ginsenosides', 'Lactobacillus delbrueckii', 'Leuconostoc', 'Panax', 'Time Factors'] | 16,086,257 | [['B01.300.381.081'], ['B01.300.381.081.450'], ['B03.510.024.100', 'B03.510.460.400.400.049.100'], ['E05.196.181.400.300'], ['E05.196.181.400.537'], ['D08.811'], ['H01.158.273.540.274.332', 'J01.576.423.850.730.500.249.300', 'N06.850.425.200', 'N06.850.460.400.300', 'N06.850.601.500.249.300'], ['D02.455.849.919.277', '... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 |
High-field MRI and mercury release from dental amalgam fillings. | Mercury is among the most toxic nonradioactive elements which may cause toxicity even at low doses. Some studies showed release of mercury from dental amalgam fillings in individuals who used mobile phone. This study was conducted to assess the effect of high-field MRI on mercury release from dental amalgam filling. We... | ['Adult', 'Dental Amalgam', 'Dental Restoration, Permanent', 'Electromagnetic Fields', 'Female', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Mercury', 'Spectrophotometry, Atomic', 'Young Adult'] | 24,748,001 | [['M01.060.116'], ['D25.339.208.291', 'J01.637.051.339.208.291'], ['E06.323.428', 'E06.780.346.737', 'E07.695.190.190'], ['G01.358.500.260', 'G01.358.750.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['D01.268.556.504', 'D01.268.956.437', 'D01.552.544.504'], ['E05.196.712.726.551', 'E... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 |
The role of alkalizing and neutral potassium salts in urinary bladder carcinogenesis in rats. | Using an initiation-promotion rat model, we have previously shown that the alkalizing salt KHCO3 is a strong and the neutral salt KCl a weak promoter of urinary bladder carcinogenesis. We have now studied the effects of these salts on rat urinary bladder epithelium without prior exposure to a bladder tumour initiator. ... | ['Animals', 'Bicarbonates', 'Female', 'Hydrogen-Ion Concentration', 'Hyperplasia', 'Male', 'Potassium Chloride', 'Potassium Compounds', 'Precancerous Conditions', 'Rats', 'Rats, Wistar', 'Time Factors', 'Urinary Bladder', 'Urinary Bladder Neoplasms', 'Urine'] | 8,118,937 | [['B01.050'], ['D01.200.275.150.100', 'D01.248.497.158.165.100'], ['G02.300'], ['C23.550.444'], ['D01.210.450.150.750', 'D01.745.625'], ['D01.745'], ['C04.834'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.900'], ['G01.910.857'], ['A05.810.890'], ['C04.588.945.947.960', 'C12.7... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Adenocarcinoma of the gallbladder--accidental finding during laparoscopic cholecystectomy]. | The authors present a unique case-history of adenocarcinoma of the gallbladder detected on laparoscopic surgery and the surprising favourable postoperative course considering the diagnosis. They draw attention to the difficult preoperative diagnosis of adenocarcinoma of the gallbladder and the necessity of a radical ap... | ['Adenocarcinoma', 'Cholecystectomy, Laparoscopic', 'Cholecystitis', 'Female', 'Gallbladder Neoplasms', 'Humans', 'Middle Aged'] | 11,688,245 | [['C04.557.470.200.025'], ['E04.210.120.172.140', 'E04.502.250.520.160'], ['C06.130.564.263'], ['C04.588.274.120.401', 'C06.130.320.401', 'C06.130.564.401', 'C06.301.120.401'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630']] | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Development of topical hydrogels of terbinafine hydrochloride and evaluation of their antifungal activity. | The purpose of this study was to prepare hydrogels and microemulsion (ME)-based gel formulations containing 1% terbinafine hydrochloride (TER-HCL) and to evaluate the use of these formulations for the antifungal treatment of fungal infections. Three different hydrogel formulations were prepared using chitosan, Carbopol... | ['Acrylates', 'Administration, Topical', 'Anti-Infective Agents, Local', 'Antifungal Agents', 'Aspergillus niger', 'Candida', 'Cellulose', 'Chemical Phenomena', 'Chitosan', 'Drug Compounding', 'Drug Delivery Systems', 'Drug Liberation', 'Drug Stability', 'Drug Storage', 'Emulsions', 'Gels', 'Hydrogels', 'Microbial Sens... | 24,576,265 | [['D02.241.081.069'], ['E02.319.267.120'], ['D27.505.954.122.187'], ['D27.505.954.122.136'], ['B01.300.381.081.450'], ['B01.300.107.795.095', 'B01.300.381.147', 'B01.300.930.176'], ['D05.750.078.562.180', 'D09.698.365.180', 'D25.720.099.500', 'J01.637.051.720.099.500'], ['G02'], ['D05.750.078.139.500', 'D09.698.211.500... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Nanostructure of a poly(acrylic acid) brush and its transition in the amphiphilic diblock copolymer monolayer on the water surface. | The nanostructure and its transition of in a poly(acrylic acid) (PAA) brush in the water surface monolayers of poly(hydrogenated isoprene)-b-poly(acrylic acid) with different block lengths and block ratios were investigated by X-ray reflectivity as a function of surface pressure (brush density) and salt concentration i... | ['Acrylates', 'Nanostructures', 'Phase Transition', 'Polymers', 'Polymethacrylic Acids', 'Polystyrenes', 'Water'] | 19,583,229 | [['D02.241.081.069'], ['J01.637.512'], ['G01.645', 'G02.734'], ['D05.750', 'D25.720', 'J01.637.051.720'], ['D02.241.081.069.800', 'D05.750.716.822.111.650', 'D25.720.716.822.111.650', 'J01.637.051.720.716.822.111.650'], ['D02.455.426.559.389.150.750.800.830', 'D05.750.716.579', 'D25.720.716.579', 'J01.637.051.720.716.5... | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Spleen-targeted 114In(m) via normal and heat-damaged red cells in the mouse: isotope distribution and bone marrow damage. | 114In(m)-labelled heat-damaged erythrocytes (HDRBC) in BDF1 mice were quantitatively much less successful in spleen targeting than in the rat. Unheated labelled cells (NRBC) were an even less effective vector. Radiobiological effects manifest in the spleen (weight loss) and white cell count were nevertheless substantia... | ['Animals', 'Erythrocytes', 'Hematopoietic Stem Cells', 'Hot Temperature', 'Indium Radioisotopes', 'Liver', 'Male', 'Mice', 'Spleen', 'Tissue Distribution'] | 11,065,158 | [['B01.050'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['A11.148.378', 'A11.872.378', 'A15.378.316.378'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.775.710.380', 'N06.230.300.100.725.232', 'N06.230.300.100.725.710.380'], ['D01.496.749.460'], ['A03.620'], ['B01.050.150.900.649.313.992.635... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
An unusual association between acute ischaemic stroke and cerebral venous thrombosis with thyrotoxic state. | Arterial cerebral ischaemia has been described in different diseases of the thyroid. Likewise, cerebral venous thrombosis (CVT) has been reported in association with hyperthyroidism. However, the association of arterial and venous cerebral ischaemic events in patients with hyperthyroidism has not been previously descri... | ['Decompressive Craniectomy', 'Diagnosis, Differential', 'Diagnostic Imaging', 'Female', 'Humans', 'Intracranial Thrombosis', 'Stroke', 'Thyrotoxicosis', 'Young Adult'] | 24,311,416 | [['E04.188.200', 'E04.525.190.200'], ['E01.171'], ['E01.370.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.228.140.300.525.425', 'C14.907.253.566.350', 'C14.907.355.590.213.350'], ['C10.228.140.300.775', 'C14.907.253.855'], ['C19.874.397.685'], ['M01.060.116.815']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Evaluation of amniotic fluid as a skin graft storage media compared with RPMI and saline. | We aimed to assess and compare the histological changes of grafts stored in Roswell Park Memorial Institute-1640 solution (RPMI), amniotic fluid (AF), and saline. Amniotic fluid which has abundant nutrients, proteins, and growth factors, and antimicrobial features may be an easily achievable and cheap alternative for t... | ['Amniotic Fluid', 'Collagen', 'Fibroblasts', 'Humans', 'Organ Preservation Solutions', 'Skin', 'Skin Transplantation', 'Tissue Preservation'] | 21,269,778 | [['A12.098', 'A16.378.149'], ['D05.750.078.280', 'D12.776.860.300.250'], ['A11.329.228'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D26.776.675'], ['A17.815'], ['E02.095.147.725.700', 'E04.680.275.850', 'E04.936.580.700'], ['E01.370.225.500.620.760', 'E01.370.225.750.600.760', 'E02.792.833', 'E05.200.500.620.7... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Lymphovascular invasion is independently associated with poor prognosis in patients with localized upper urinary tract urothelial carcinoma treated surgically. | PURPOSE: We explored the prognostic impact of lymphovascular invasion in patients with localized upper urinary tract urothelial carcinoma.MATERIALS AND METHODS: The clinical records of 135 patients treated surgically for localized upper urinary tract urothelial carcinoma (pTa-3N0M0) were reviewed retrospectively. Lymph... | ['Aged', 'Aged, 80 and over', 'Carcinoma, Transitional Cell', 'Cystectomy', 'Female', 'Humans', 'Lymph Nodes', 'Lymphatic Vessels', 'Male', 'Middle Aged', 'Multivariate Analysis', 'Neoplasm Invasiveness', 'Neoplasm Recurrence, Local', 'Neoplasm Staging', 'Predictive Value of Tests', 'Prognosis', 'Proportional Hazards M... | 17,936,818 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['C04.557.470.200.430'], ['E04.950.774.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A10.549.400', 'A15.382.520.604.412'], ['A15.382.520.301'], ['M01.060.116.630'], ['E05.318.740.150.500', 'N05.715.360.750.125.500', 'N06.850.520.830.150.500'], ['C04.697.645', '... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Six dangerous myths about pay. | Every day, executives make decisions about pay, and they do so in a landscape that's shifting. As more and more companies base less of their compensation on straight salary and look to other financial options, managers are bombarded with advice about the best approaches to take. Unfortunately, much of that advice is wr... | ['Commerce', 'Employee Incentive Plans', 'Humans', 'Job Satisfaction', 'Organizational Culture', 'Organizational Policy', 'Psychology, Industrial', 'Salaries and Fringe Benefits', 'United States'] | 10,179,647 | [['J01.219'], ['N04.452.677.368'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.784.692.425'], ['N04.452.606'], ['I01.655.500.550', 'I01.880.604.825.550', 'N03.623.500.550'], ['F02.784.692', 'F04.096.628.779'], ['N01.824.417.700', 'N04.452.677.800'], ['Z01.107.567.875']] | ['Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 |
Prion protein expression and release by mast cells after activation. | In this study, we compared hematopoietic stem cells and mast cells, using microarray expression analysis, and identified the cellular prion protein (PrP(C)) as a potentially novel marker of mast cells. On further investigation, we found that PrP(C) is expressed on the surface of human and mouse mast cells, is rapidly r... | ['Animals', 'Biomarkers', 'Gene Expression Profiling', 'Hematopoietic Stem Cells', 'Humans', 'Mast Cells', 'Mice', 'Mice, Inbred C57BL', 'Prion Proteins', 'Prions'] | 19,642,931 | [['B01.050'], ['D23.101'], ['E05.393.332'], ['A11.148.378', 'A11.872.378', 'A15.378.316.378'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.329.427', 'A15.382.652'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420'], ['D12.776.395.5... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Assessment of the age of atherosclerosis risk in population studies using a two factorial mathematical model. | The risk of atherosclerosis was assessed using a mathematical model of competition between LDL and HDL on 365 randomly selected persons. The results speak for the fact that the risk falls between the ages of 30 and 40 years for males, and 40 and 50 years for females. We are of the opinion that our procedure may be vali... | ['Adult', 'Age Factors', 'Aged', 'Aged, 80 and over', 'Arteriosclerosis', 'Cholesterol, HDL', 'Cholesterol, LDL', 'Cross-Sectional Studies', 'Female', 'Humans', 'Incidence', 'Male', 'Middle Aged', 'Models, Theoretical', 'Risk Factors', 'Spain'] | 1,877,291 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C14.907.137.126'], ['D04.210.500.247.808.197.238', 'D10.532.432.400', 'D10.570.938.208.270', 'D12.776.521.479.470'], ['D04.210.500.247.808.197.244', 'D10.532.515.500', 'D10.570.938.208.275', 'D12.776.521.550.500'],... | ['Named Groups [M]', 'Health Care [N]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Stomatococcus mucilaginosus produces a mannose-containing lipoglycan rather than lipoteichoic acid. | Five strains of Stomatococcus mucilaginosus were investigated to determine whether the organism produces a lipoteichoic acid or a lipoglycan. Crude phenol extracts were purified by hydrophobic interaction chromatography and shown to contain lipoglycan. The major carbohydrate component present was mannose, indicating th... | ['Fatty Acids', 'Lipopolysaccharides', 'Mannose', 'Micrococcaceae', 'Teichoic Acids'] | 7,710,324 | [['D10.251'], ['D09.400.500', 'D09.698.718.450', 'D10.494', 'D23.050.161.616.525', 'D23.946.123.329.500'], ['D09.947.875.359.588'], ['B03.510.024.850', 'B03.510.400.500'], ['D09.408.872', 'D09.698.718.825', 'D09.894.847', 'D23.050.161.616.797']] | ['Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Antidepressant effect of femoxetine and desipramine and relationship to the concentration of amine metabolites in cerebrospinal fluid. A double-blind evaluation. | The antidepressant and biochemical effects of femoxetine, a selective serotonin uptake inhibitor, and desipramine, a selective nor-adrenaline uptake inhibitor, have been compared in a double-blind study in 42 outpatients with depressive illness. The patients were allocated at random to treatment with either 600 mg femo... | ['Adult', 'Aged', 'Antidepressive Agents', 'Depressive Disorder', 'Desipramine', 'Double-Blind Method', 'Female', 'Glycols', 'Homovanillic Acid', 'Humans', 'Hydroxyindoleacetic Acid', 'Male', 'Methoxyhydroxyphenylglycol', 'Middle Aged', 'Phenylacetates', 'Piperidines'] | 6,181,653 | [['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.427.700.122'], ['F03.600.300'], ['D03.633.300.240.281'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['D02.033.455'], ['D02.241.223.601.521'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.066.288.478', 'D03.633.100.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Left ventricular responses to experimental aortic coarctation in growing puppies. | The haemodynamic status of 8 coarctated and 7 sham-operated beagle puppies was studied by a catheterization technique at rest and during isoproterenol and volume loading at the ages of 7 (I) and 9 (II) months (5 and 7 months after the experimental coarctation). Proximal aortic systolic and pulse pressures were constant... | ['Aging', 'Animals', 'Aortic Coarctation', 'Blood Pressure', 'Collateral Circulation', 'Dogs', 'Heart Ventricles', 'Hemodynamics', 'Isoproterenol', 'Time Factors'] | 1,858,510 | [['G07.345.124'], ['B01.050'], ['C14.240.400.090', 'C14.280.400.090', 'C16.131.240.400.090'], ['E01.370.600.875.249', 'G09.330.380.076'], ['G09.330.100.248'], ['B01.050.150.900.649.313.750.250.216.200'], ['A07.541.560'], ['G09.330.380'], ['D02.033.100.291.439', 'D02.092.063.291.439', 'D02.092.311.649', 'D02.455.426.559... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
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