Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Downregulation of CYP2A6 and CYP2C8 in Tumor Tissues Is Linked to Worse Overall Survival and Recurrence-Free Survival from Hepatocellular Carcinoma. | Objective: This study aimed to evaluate the links between CYP450 family genes in tumor tissues and hepatocellular carcinoma (HCC) outcomes.Methods: Gene Expression Omnibus (GEO) databases GSE14520 and GSE36376 were used to identify differential expressed CYP450 genes between tumor and nontumor tissues and related to HC... | ['Carcinoma, Hepatocellular', 'Cytochrome P-450 CYP2A6', 'Cytochrome P-450 CYP2C8', 'Disease-Free Survival', 'Down-Regulation', 'Humans', 'Liver Neoplasms', 'Neoplasm Staging', 'Prognosis', 'Republic of Korea'] | 30,148,168 | [['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['D08.244.453.491.250', 'D08.811.682.690.708.170.450.250', 'D12.776.422.220.453.491.250'], ['D08.244.453.005.590', 'D08.244.453.491.368', 'D08.811.682.690.708.170.010.590', 'D08.811.682.690.708.170.450.360', 'D12.776.422.220.453.... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Hexavalent chromium intoxication induces intrinsic and extrinsic apoptosis in human renal cells. | Hexavalent chromium [Cr(VI)], is a well‑known toxic form of the heavy metal chromium in the natural environment. Clinical evidence has indicated that exposure to Cr(VI) can cause severe renal damage. The production of reactive oxygen species (ROS) due to intracellular reduction of Cr(VI) is the main mechanism underlyin... | ['Adult', 'Apoptosis', 'Caspases', 'Cell Line', 'Cell Shape', 'Cell Survival', 'Chromium', 'Humans', 'Intracellular Space', 'Kidney', 'Models, Biological', 'Reactive Oxygen Species'] | 31,974,625 | [['M01.060.116'], ['G04.146.954.035'], ['D08.811.277.656.262.500.126', 'D08.811.277.656.300.200.126', 'D12.644.360.075.405', 'D12.776.476.075.405'], ['A11.251.210'], ['G04.320'], ['G04.346'], ['D01.268.556.175', 'D01.268.956.124', 'D01.552.544.175'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A10.082.750', 'A11... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Judgments of origin and generation effects: comparisons between young and elderly adults. | In 2 experiments, young and elderly adults were required to both read words, and generate words by completing word fragments. Subjects were then required to recognize those words that had been presented earlier; for those words that they recognized they judged whether the items had initially been presented in read or g... | ['Adult', 'Aged', 'Aging', 'Attention', 'Ego', 'Female', 'Humans', 'Imagination', 'Male', 'Memory', 'Mental Recall', 'Middle Aged', 'Reading', 'Reality Testing', 'Retention, Psychology', 'Verbal Behavior', 'Verbal Learning'] | 2,803,618 | [['M01.060.116'], ['M01.060.116.100'], ['G07.345.124'], ['F02.830.104.214'], ['F01.752.747.189', 'F02.739.794.206'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.188.634'], ['F02.463.425.540'], ['F02.463.425.540.641'], ['M01.060.116.630'], ['L01.559.423.557'], ['F01.752.747.189.508', 'F02.739.794.206.508'... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Polymorphisms in drug-metabolizing enzymes and steady-state exemestane concentration in postmenopausal patients with breast cancer. | Discovery of clinical and genetic predictors of exemestane pharmacokinetics was attempted in 246 postmenopausal patients with breast cancer enrolled on a prospective clinical study. A sample was collected 2 h after exemestane dosing at a 1- or 3-month study visit to measure drug concentration. The primary hypothesis wa... | ['Androstadienes', 'Antineoplastic Agents', 'Breast Neoplasms', 'Cytochrome P-450 CYP3A', 'Female', 'Genotyping Techniques', 'Humans', 'Middle Aged', 'Pharmacogenomic Testing', 'Pharmacogenomic Variants', 'Polymorphism, Single Nucleotide', 'Postmenopause', 'Precision Medicine', 'Predictive Value of Tests'] | 27,549,341 | [['D04.210.500.054.079.129'], ['D27.505.954.248'], ['C04.588.180', 'C17.800.090.500'], ['D08.244.453.860.500', 'D08.811.682.662.582.353', 'D08.811.682.690.708.170.495.500', 'D12.776.422.220.453.860.500'], ['E05.393.442'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.370.225.562.500', 'E05... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Xenin-25 potentiates glucose-dependent insulinotropic polypeptide action via a novel cholinergic relay mechanism. | The intestinal peptides GLP-1 and GIP potentiate glucose-mediated insulin release. Agents that increase GLP-1 action are effective therapies in type 2 diabetes mellitus (T2DM). However, GIP action is blunted in T2DM, and GIP-based therapies have not been developed. Thus, it is important to increase our understanding of... | ['Animals', 'Blood Glucose', 'Blotting, Western', 'Carbachol', 'Cell Line, Tumor', 'Cholinergic Agonists', 'Drug Synergism', 'Enzyme-Linked Immunosorbent Assay', 'Fasting', 'Female', 'Gastric Inhibitory Polypeptide', 'Glucagon-Like Peptide 1', 'Glucose', 'Humans', 'Insulin', 'Insulin Secretion', 'Insulin-Secreting Cell... | 20,421,298 | [['B01.050'], ['D09.947.875.359.448.500'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['D02.092.877.883.333.115', 'D02.675.276.232.115'], ['A11.251.210.190', 'A11.251.860.180'], ['D27.505.519.625.120.140', 'D27.505.696.577.120.140'], ['G07.690.773.968.477'], ['E... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Field experience with the bovine lungworm vaccine. | Field experience of a bovine lungworm vaccine, acquired over the past 25 years, is discussed with regard to the use of other putative parasitic vaccines. It was concluded that the parameters were generally similar to those for non-parasitic vaccines although the fact that the lungworm vaccine does not confer a parasito... | ['Animals', 'Anthelmintics', 'Cattle', 'Cattle Diseases', 'Dictyocaulus', 'Dictyocaulus Infections', 'Larva', 'Trichostrongyloidea', 'Vaccination', 'Vaccines'] | 2,938,996 | [['B01.050'], ['D27.505.954.122.250.075'], ['B01.050.150.900.649.313.500.380.271'], ['C22.196'], ['B01.050.500.500.294.400.968.746.300'], ['C01.610.335.349.315', 'C01.610.335.508.700.775.825.315', 'C01.610.701.377.315', 'C22.674.377.315'], ['B05.500.500', 'G07.345.500.550.500.500'], ['B01.050.500.500.294.400.968.746'],... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Milk metabolites and their genetic variability. | The composition of milk is crucial to evaluate milk performance and quality measures. Milk components partly contribute to breeding scores, and they can be assessed to judge metabolic and energy status of the cow as well as to serve as predictive markers for diseases. In addition to the milk composition measures (e.g.,... | ['Animals', 'Breeding', 'Cattle', 'Fats', 'Female', 'Genetic Variation', 'Germany', 'Lactose', 'Linear Models', 'Milk', 'Milk Proteins', 'Pedigree', 'Phenotype', 'Polymorphism, Single Nucleotide', 'Quantitative Trait, Heritable'] | 23,403,187 | [['B01.050'], ['E05.820.150', 'G05.090'], ['B01.050.150.900.649.313.500.380.271'], ['D10.212'], ['G05.365'], ['Z01.542.315'], ['D09.698.629.305.340', 'D09.947.750.340'], ['E05.318.740.500.500', 'E05.318.740.750.425', 'E05.599.835.750', 'N05.715.360.750.530.460', 'N05.715.360.750.695.460', 'N06.850.520.830.500.500', 'N0... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Health Care [N]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
Thiol-dependent passive K/Cl transport in sheep red cells: II. Loss of Cl- and N-ethylmaleimide sensitivity in maturing high K+ cells. | A fraction of the passive, ouabain-insensitive K+ fluxes in mature low Kr(LK) but not in high K+ (HK) sheep red cells requires the presence of Cl- anions and can be stimulated by volume expansion (Dunham, P.B., Ellory, J.C., J. Physiol (London) 318:511-530, 1981) or treatment with 2 mM N-ethylmaleimide (NEM) (Lauf, P.K... | ['Anemia', 'Animals', 'Biological Transport', 'Chlorides', 'Erythrocytes', 'Ethylmaleimide', 'In Vitro Techniques', 'Nitrates', 'Potassium', 'Reticulocytes', 'Sheep', 'Sodium'] | 6,864,777 | [['C15.378.071'], ['B01.050'], ['G03.143'], ['D01.210.450.150', 'D01.248.497.158.215'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['D02.241.081.337.502.524.418', 'D02.478.440.418', 'D03.383.129.578.399.418'], ['E05.481'], ['D01.248.497.158.606', 'D01.625.525.550', 'D02.583'], ['D01.268.549.550', 'D01.268.557.5... | ['Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A Community Study on the Relationship of Posttraumatic Cognitions to Internalizing and Externalizing Psychopathology in Taiwanese Children and Adolescents. | A growing number of studies indicate that posttraumatic cognitions play a crucial role in the development and maintenance of posttraumatic stress disorder (PTSD). However, the effects of posttraumatic cognitions on general psychopathology beyond PTSD remain unclear. The current study aimed to validate the Chinese versi... | ['Adolescent', 'Adolescent Behavior', 'Child', 'Child Behavior', 'Female', 'Humans', 'Male', 'Problem Behavior', 'Psychiatric Status Rating Scales', 'Psychological Trauma', 'Reproducibility of Results', 'Stress Disorders, Post-Traumatic', 'Taiwan'] | 25,957,269 | [['M01.060.057'], ['F01.145.022'], ['M01.060.406'], ['F01.145.179'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.126.972', 'F01.145.179.750'], ['F04.711.513.653'], ['F03.950.750.375'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['F03.950.750.500'], ['Z01.252.474.872... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Maternal and neonatal outcomes in pregnancies complicated by gestational diabetes. a nation-wide study. | OBJECTIVE: To estimate the association between gestational diabetes mellitus (GDM) and adverse pregnancy and neonatal outcomes in Denmark.METHODS: A population-based cohort study including all singleton pregnancies in Denmark from 2004 to 2010 (n = 403 092). Maternal complications during pregnancy and delivery and feta... | ['Adult', 'Apgar Score', 'Denmark', 'Diabetes, Gestational', 'Female', 'Fetal Macrosomia', 'Humans', 'Infant, Newborn', 'Male', 'Obstetric Labor Complications', 'Pregnancy', 'Pregnancy Complications', 'Pregnancy Outcome', 'Registries', 'Risk Factors', 'Stillbirth'] | 25,228,278 | [['M01.060.116'], ['E01.370.600.050'], ['Z01.542.816.124'], ['C13.703.170', 'C18.452.394.750.448', 'C19.246.200'], ['C13.703.170.500', 'C13.703.277.570', 'C13.703.726.570', 'C16.300.570', 'C19.246.099.968', 'C23.888.144.186.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['C13.703.420'], ['... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Frequency of neurogenic thoracic outlet syndrome in patients with definite carpal tunnel syndrome: an electrophysiological evaluation in 100 women. | OBJECTIVE: The aim of this work was to evaluate the frequency of lower brachial plexus lesions as true neurogenic thoracic outlet syndrome (NTOS) in women with carpal tunnel syndrome (CTS).METHODS: This was a prospective and descriptive study. The CTS was clinically and electrodiagnostically defined in each patient. Th... | ['Action Potentials', 'Adult', 'Aged', 'Aged, 80 and over', 'Brachial Plexus', 'Carpal Tunnel Syndrome', 'Electrodiagnosis', 'Female', 'Humans', 'Incidence', 'Middle Aged', 'Nervous System', 'Neural Conduction', 'Neurons, Afferent', 'Prospective Studies', 'Sensitivity and Specificity', 'Skin', 'Thoracic Outlet Syndrome... | 15,661,102 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['A08.800.800.720.050'], ['C10.668.829.500.500.200', 'C10.668.829.550.200', 'C26.844.150.206'], ['E01.370.405'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.93... | ['Phenomena and Processes [G]', 'Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Netrin-1 overexpression improves neurobehavioral outcomes and reduces infarct size via inhibition of the notch1 pathway following experimental stroke. | Stroke is a leading cause of morbidity and mortality worldwide. Administration of Netrin-1 during the peri-infarct period has been shown to decrease infarct size in rats; however, the underlying mechanism is unclear. We addressed this question in the present study by inducing stroke in rats via middle cerebral artery o... | ['Animals', 'Behavior, Animal', 'Male', 'Netrin-1', 'Rats', 'Rats, Wistar', 'Receptor, Notch1', 'Stroke', 'Up-Regulation'] | 28,084,632 | [['B01.050'], ['F01.145.113'], ['D12.644.276.860.494.500', 'D12.776.467.860.494.500', 'D12.776.631.600.494.500', 'D12.776.860.300.731.500', 'D23.125.842.500', 'D23.529.850.494.500'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.900'], ['D12.776.543.750.725.500', 'D12.776.930.77... | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Prediction of Airflow Obstruction and the Risk of Complications in Morbidly Obese Patients Undergoing Bariatric Surgery. | Morbidly obese subjects with airflow obstruction who underwent laparoscopic bariatric surgery appear to have the greatest risk to develop complications. In a retrospective cohort study, we identified a waist circumference ? 120 cm, smoking history ?5PY and history of obstructive lung disease as statistically significan... | ['Adult', 'Algorithms', 'Bariatric Surgery', 'Female', 'Humans', 'Male', 'Middle Aged', 'Morbidity', 'Obesity, Morbid', 'Postoperative Complications', 'Prognosis', 'Prospective Studies', 'Pulmonary Disease, Chronic Obstructive', 'Retrospective Studies', 'Risk Factors'] | 31,179,507 | [['M01.060.116'], ['G17.035', 'L01.224.050'], ['E02.650.500.062', 'E04.062'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.308.985.525', 'N01.224.935.597', 'N06.850.505.400.975.525', 'N06.850.520.308.985.525'], ['C18.654.726.500.700', 'C23.888.144.699.500.500', 'E01.370.600.115.100.16... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Preliminary use of endoluminal ultrasonography in assessment of middle ear with effusion. | Endoluminal ultrasonography with small-caliber and high-frequency transducer is suitable for transcanal assessment of middle ear with effusion. An endoluminal ultrasound transducer (size 6 French, 20 MHz) with a side-viewing scanning plane was used to image 12 ears of six children suspected of having effusion in the mi... | ['Child', 'Child, Preschool', 'Endosonography', 'Female', 'Humans', 'Male', 'Otitis Media with Effusion'] | 9,669,300 | [['M01.060.406'], ['M01.060.406.448'], ['E01.370.350.850.280'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C09.218.705.663.670']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Phenotype characteristics of skin dendritic cells in patients with psoriatic arthritis during the treatment with deresinated naphthalan]. | The study of the phenotype of immunocompetent dendritic cells of the skin in patients with psoriatic arthritis in the course of treatment with deresinated naphthalan (DRN) has revealed some aspects of the mechanism of therapeutic action of DRN. Use of the complex of monoclonal antibodies allowed the authors to determin... | ['Anti-Inflammatory Agents, Non-Steroidal', 'Antigens, Surface', 'Arthritis, Psoriatic', 'Dendritic Cells', 'Female', 'HLA-DR Antigens', 'Humans', 'Immunophenotyping', 'Male', 'Naphthalenes', 'Skin'] | 11,561,301 | [['D27.505.696.663.850.014.040.500', 'D27.505.954.158.030', 'D27.505.954.329.030'], ['D23.050.301'], ['C05.116.900.853.625.800.424', 'C05.550.114.145', 'C05.550.114.865.800.424', 'C17.800.859.675.175'], ['A11.066.270', 'A11.436.270', 'A15.382.066.270', 'A15.382.670.260'], ['D12.776.395.550.509.400.440', 'D12.776.543.55... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Breech delivery and epidural analgesia. | OBJECTIVE: To examine the effect of epidural analgesia on the progress and outcome of spontaneous labour in women with a singleton breech presentation at term (greater than or equal to 37 weeks).DESIGN: A retrospective study.SETTING: Data Bank, Aberdeen Maternity Hospital.SUBJECTS: 643 women (273 primiparae and 370 mul... | ['Adult', 'Analgesia, Epidural', 'Analgesia, Obstetrical', 'Breech Presentation', 'Cesarean Section', 'Female', 'Humans', 'Oxytocin', 'Parity', 'Pregnancy', 'Pregnancy Trimester, Third', 'Retrospective Studies', 'Trial of Labor'] | 1,294,064 | [['M01.060.116'], ['E03.091.080'], ['E03.091.110'], ['C13.703.420.183', 'G08.686.520.150', 'G08.686.784.769.326.520.150'], ['E04.520.252.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D06.472.699.631.692.433', 'D12.644.548.691.692.433'], ['G08.686.677', 'G08.686.784.769.472', 'N06.850.490.812.600'], ['G08.68... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A unique ferrous iron binding mode is associated with large conformational changes for the transport protein FpvC of Pseudomonas aeruginosa. | Pseudomonas aeruginosa secretes pyoverdine, a major siderophore to get access to iron, an essential nutrient. Pyoverdine scavenges ferric iron in the bacterial environment with the resulting complex internalized by bacteria. Releasing of iron from pyoverdine in the periplasm involves an iron reduction by an inner membr... | ['Bacterial Outer Membrane Proteins', 'Binding Sites', 'Iron', 'Molecular Dynamics Simulation', 'Nickel', 'Oligopeptides', 'Protein Binding', 'Pseudomonas aeruginosa', 'Solute Carrier Proteins'] | 31,318,478 | [['D12.776.097.120', 'D12.776.543.100'], ['G02.111.570.120'], ['D01.268.556.412', 'D01.268.956.287', 'D01.552.544.412'], ['E05.599.595.500', 'G02.111.570.895', 'L01.224.160.500'], ['D01.268.556.607', 'D01.268.956.625', 'D01.552.544.607'], ['D12.644.456'], ['G02.111.679', 'G03.808'], ['B03.440.400.425.625.625.100', 'B03... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Proliferation assay on a silicon chip applicable for tumors extirpated from mammalians. | We describe a novel anticancer drug sensitivity assay on a silicon chip applicable for tumors extirpated from in vivo mammalians. Human promyelocytic leukemia (HL-60) cells were subcutaneously (s.c.) inoculated in SCID mice, then removed 31 days after the inoculation. The cells were embedded in a small volume (18 nL) o... | ['Animals', 'Antineoplastic Agents', 'Cell Division', 'Cisplatin', 'Collagen', 'Drug Screening Assays, Antitumor', 'Electrochemistry', 'Etoposide', 'Female', 'HL-60 Cells', 'Humans', 'Mice', 'Mice, SCID', 'Microcomputers', 'Microscopy', 'Neoplasms, Experimental', 'Silicon'] | 14,750,184 | [['B01.050'], ['D27.505.954.248'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['D01.210.375', 'D01.625.125', 'D01.710.100'], ['D05.750.078.280', 'D12.776.860.300.250'], ['E01.370.225.500.388', 'E05.200.500.388', 'E05.242.417', 'E05.337.550.200'], ['H01.181.529.307'], ['D02.455.426.559.847... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anatomy [A]', 'Information Science [L]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
The dementia/alzheimer's population and the security officer. | The number of patients with dementia continues to increase in both long-term and acute care facilities, the author says, and will pose new challenges to security personnel. Dealing with such patients can be made easier if some of the guidelines suggested in the article are followed. | ['Dangerous Behavior', 'Dementia', 'Health Facilities', 'Humans', 'Long-Term Care', 'Security Measures'] | 20,873,498 | [['F01.145.263', 'I01.880.735.223'], ['C10.228.140.380', 'F03.615.400'], ['N02.278'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.760.476', 'N02.421.585.476'], ['N04.452.910']] | ['Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Vasoconstrictor role for vasopressin in conscious, sodium-depleted rats. | To define the role of vasopressin as a vasoconstrictor hormone in sodium depletion, systemic hemodynamics and regional blood flow distribution were examined in conscious Sprague-Dawley rats after 6 days of a low-sodium diet. Studies were performed after selective or combined blockade with the vasopressin antagonist [d(... | ['Adaptation, Physiological', 'Adrenergic alpha-Antagonists', 'Angiotensin-Converting Enzyme Inhibitors', 'Animals', 'Arginine Vasopressin', 'Cardiovascular Physiological Phenomena', 'Enalapril', 'Enalaprilat', 'Hemodynamics', 'Male', 'Phentolamine', 'Rats', 'Rats, Inbred Strains', 'Regional Blood Flow', 'Sodium', 'Sod... | 2,889,370 | [['G07.025', 'G16.012.500'], ['D27.505.519.625.050.200.100', 'D27.505.696.577.050.200.100'], ['D27.505.519.389.745.085'], ['B01.050'], ['D06.472.699.631.692.781.100', 'D12.644.400.900.100', 'D12.644.456.925.100', 'D12.644.548.691.692.781.100', 'D12.776.631.650.937.100'], ['G09.330'], ['D12.644.456.345.360'], ['D12.644.... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Estimating coverage of a community-based home care programme. | The Family AIDS Caring Trust (FACT) was formed in Mutare, Zimbabwe's third largest city, in 1987. FACT's home care programme started in 1992. The programme operates in the urban area of Mutare which contains three townships with a population of 131,367. The area employs a trained nurse as a coordinator and four assista... | ['Acquired Immunodeficiency Syndrome', 'Adolescent', 'Adult', 'Cause of Death', 'Child', 'Child, Preschool', 'Community Health Services', 'Gastroenteritis', 'Health Care Costs', 'Health Services Needs and Demand', 'Home Care Services', 'Humans', 'Pneumonia', 'Population Surveillance', 'Program Evaluation', 'Random Allo... | 9,316,362 | [['C01.221.250.875.040', 'C01.221.812.640.400.040', 'C01.778.640.400.040', 'C01.925.782.815.616.400.040', 'C01.925.813.400.040', 'C01.925.839.040', 'C20.673.480.040'], ['M01.060.057'], ['M01.060.116'], ['E05.318.308.985.550.250', 'N01.224.935.698.100', 'N06.850.505.400.975.550.250', 'N06.850.520.308.985.550.250'], ['M0... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Nimbus: a design-driven analyses suite for amplicon-based NGS data. | Motivation: PCR-based DNA enrichment followed by massively parallel sequencing is a straightforward and cost effective method to sequence genes up to high depth. The full potential of amplicon-based sequencing assays is currently not achieved as analysis methods do not take into account the source amplicons of the dete... | ['Female', 'High-Throughput Nucleotide Sequencing', 'Humans', 'Male', 'Polymorphism, Single Nucleotide', 'Sequence Alignment', 'Sequence Analysis, DNA', 'Software'] | 29,538,618 | [['E05.393.760.319'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G05.365.795.598'], ['E05.393.751'], ['E05.393.760.700'], ['L01.224.900']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Novel potent metallocenes against liver stage malaria. | Novel conjugates of the antimalarial drug primaquine (compound 1) with ferrocene, named primacenes, have been synthesized and screened for their activities against blood stage and liver stage malaria in vitro and host-vector transmission in vivo. Both transmission-blocking and blood-schizontocidal activities of the par... | ['Animals', 'Antimalarials', 'Erythrocytes', 'Ferrous Compounds', 'Genes, Reporter', 'Green Fluorescent Proteins', 'Humans', 'Inhibitory Concentration 50', 'Liver', 'Malaria', 'Metallocenes', 'Mice', 'Mice, Inbred BALB C', 'Oocysts', 'Plasmodium berghei', 'Plasmodium falciparum', 'Primaquine', 'Sporozoites'] | 22,155,838 | [['B01.050'], ['D27.505.954.122.250.100.085'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['D01.490.200'], ['G05.360.340.024.340.435'], ['D12.776.532.265'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.940.350', 'G07.690.936.563'], ['A03.620'], ['C01.610.752.530', 'C01.920.875'], ['D02.691.657'], ['B0... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of reclaimed water matrix on fate of pharmaceuticals and personal care products in soil. | Reclaimed water is increasingly used to supplement water resources. However, reclaimed water has a complex matrix, which includes emerging chemical contaminants, that is introduced to the soil when this water is used for irrigation. The effects of microbial activity, dissolved matter, nutrients, and particulate matter ... | ['Animals', 'Household Products', 'Manure', 'Pharmaceutical Preparations', 'Soil Pollutants', 'Swine', 'Waste Disposal, Fluid', 'Water Pollutants, Chemical', 'Water Purification'] | 27,179,428 | [['B01.050'], ['J01.516'], ['D20.601'], ['D26'], ['D27.888.284.756'], ['B01.050.150.900.649.313.500.880'], ['N06.850.780.200.800.800.890', 'N06.850.860.510.900.600.900'], ['D27.888.284.903.655'], ['N06.850.780.200.800.800.900.900', 'N06.850.860.510.900.900']] | ['Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Distribution of sickle cell disease and assessment of risk factors based on transcranial Doppler values in the Gulf region. | Background/Objective: Stroke is a potentially fatal complication of sickle cell disease (SCD). Transcranial Doppler (TCD) is useful at identifying increased risk of stroke in children with SCD and vasospasm after subarachnoid hemorrhage. The main aim of this study was to determine the proportion of patients with SCD in... | ['Adolescent', 'Anemia, Sickle Cell', 'Child', 'Child, Preschool', 'Cross-Sectional Studies', 'Female', 'Humans', 'Male', 'Oman', 'Qatar', 'Retrospective Studies', 'Risk Factors', 'Ultrasonography, Doppler, Transcranial', 'United Arab Emirates'] | 31,983,291 | [['M01.060.057'], ['C15.378.071.141.150.150', 'C15.378.420.155', 'C16.320.070.150', 'C16.320.365.155'], ['M01.060.406'], ['M01.060.406.448'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.245.500.600'], ['Z01.252.245.500.690'], ... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Structural homology of reaction centers from Rhodopseudomonas sphaeroides and Rhodopseudomonas viridis as determined by x-ray diffraction. | Crystals of the reaction center (RC) from Rhodopseudomonas sphaeroides with the space group P2(1)2(1)2(1), have been studied by x-ray diffraction. The Patterson search (molecular replacement) technique was used to analyze the data, with the structure of the reaction center from Rhodopseudomonas viridis as a model syste... | ['Bacterial Proteins', 'Electron Spin Resonance Spectroscopy', 'Photosynthetic Reaction Center Complex Proteins', 'Rhodopseudomonas', 'X-Ray Diffraction'] | 3,022,298 | [['D12.776.097'], ['E05.196.867.519.274'], ['D05.500.562.488', 'D08.811.600.710', 'D12.776.543.930.500', 'D12.776.765.199.750.750'], ['B03.440.400.425.200.700', 'B03.660.050.035.700'], ['E05.196.309.742', 'E05.196.822.950', 'G01.867.950', 'G02.965']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Draconian restrictions on visitors help no one. | A couple of years ago, I was asked to meet two women who wanted to tell me about John's Campaign. I spent a revelatory hour with Nicci Gerrard and Julia Jones, hearing why they started the campaign and what they hoped to achieve. | ['Dementia', 'Health Policy', 'Health Promotion', 'Humans', 'Infection Control', 'United Kingdom', 'Visitors to Patients'] | 27,861,042 | [['C10.228.140.380', 'F03.615.400'], ['I01.655.500.608.400', 'I01.880.604.825.608.400', 'N03.623.500.608.428'], ['I02.233.332.445', 'N02.421.726.407.579'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N06.850.780.200.450'], ['Z01.542.363'], ['M01.935']] | ['Diseases [C]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Pthlh, a promising cancer modifier gene in rat tongue carcinogenesis. | Susceptibly to the induction of rat tongue cancer (TC) by oral 4-nitroquinoline 1-oxide (4NQO) exposure is a polygenic trait. Among several quantitative trait loci identified by crosses between TC-susceptible Dark Agouti (DA) rats and TC-resistant Wistar-Furth (WF) rats, we focused on tongue cancer susceptibility locus... | ['4-Nitroquinoline-1-oxide', 'Animals', 'Base Sequence', 'Carcinogens', 'Cell Transformation, Neoplastic', 'Genetic Predisposition to Disease', 'Oligonucleotide Array Sequence Analysis', 'Parathyroid Hormone-Related Protein', 'Polymorphism, Single Nucleotide', 'Proto-Oncogene Proteins p21(ras)', 'Quantitative Trait Loc... | 24,253,735 | [['D02.640.820.600', 'D03.633.100.810.470.450', 'D03.661.243.500'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D27.888.569.100'], ['C04.697.098.500', 'C23.550.727.098.500'], ['C23.550.291.687.500', 'G05.380.355'], ['E05.393.661.640', 'E05.393.760.640', 'E05.588.570.660', 'E05.601.640'], [... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Contributions of the individual hydrophobic clefts of the Escherichia coli beta sliding clamp to clamp loading, DNA replication and clamp recycling. | The homodimeric Escherichia coli beta sliding clamp contains two hydrophobic clefts with which proteins involved in DNA replication, repair and damage tolerance interact. Deletion of the C-terminal five residues of beta (beta(C)) disrupted both clefts, severely impairing interactions of the clamp with the DnaX clamp lo... | ['Bacterial Proteins', 'DNA', 'DNA Polymerase III', 'DNA Replication', 'Escherichia coli Proteins', 'Hydrophobic and Hydrophilic Interactions', 'Protein Binding', 'Protein Multimerization', 'Protein Subunits', 'Sequence Deletion'] | 19,279,187 | [['D12.776.097'], ['D13.444.308'], ['D08.811.913.696.445.308.300.235'], ['G02.111.225', 'G05.226'], ['D12.776.097.275'], ['G02.409'], ['G02.111.679', 'G03.808'], ['G02.111.694'], ['D12.776.813'], ['G05.365.590.762', 'G05.558.800']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Substitution of soft tissue defects of septic origin on the back of the hand by transplantation of a free composite flap]. | Authors report on substitution of severe skin and extensor tendon defect on the back of the hand, developed after a II. grade open septic metacarpal fracture. For the covering of the defect of the soft tissue the paratenon--tendon--skin free flap unit was used, supplied by the a. dorsalis pedis. In one operation the sk... | ['Accidents, Occupational', 'Adult', 'Hand Injuries', 'Humans', 'Male', 'Surgical Flaps', 'Wound Infection'] | 1,675,302 | [['N06.850.135.240'], ['M01.060.116'], ['C26.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A10.850.710', 'E07.862.710'], ['C01.947']] | ['Health Care [N]', 'Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A tale of two counties: expanding health insurance coverage for children in California. | During difficult economic times, many California counties have expanded health insurance coverage for low-income children. These Children's Health Initiatives (CHIs) enroll children in public programs and provide new health insurance, Healthy Kids, for those ineligible for existing programs. This article describes the ... | ['Adolescent', 'California', 'Child', 'Child Health Services', 'Child, Preschool', 'Emigration and Immigration', 'Health Plan Implementation', 'Health Policy', 'Humans', 'Infant', 'Infant, Newborn', 'Insurance, Health', 'Local Government', 'Policy Making', 'Poverty', 'Universal Health Insurance'] | 16,953,809 | [['M01.060.057'], ['Z01.107.567.875.580.200', 'Z01.107.567.875.760.200'], ['M01.060.406'], ['N02.421.143.130'], ['M01.060.406.448'], ['I01.240.600.525.500', 'N01.224.625.525.500', 'N06.850.505.400.700.525.500'], ['N03.349.300'], ['I01.655.500.608.400', 'I01.880.604.825.608.400', 'N03.623.500.608.428'], ['B01.050.150.90... | ['Named Groups [M]', 'Geographicals [Z]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Dopamine D1 receptors regulate the extracellular citrulline level in the nucleus accumbens during performance of a conditioned reflex fear reaction. | Intracerebral microdialysis studies on Sprague-Dawley rats using HPLC showed that performance of a conditioned reflex fear reaction was accompanied by an increase in the extracellular citrulline (a co-product of nitric oxide synthesis) level in the nucleus accumbens. Administration of the selective D1 receptor antagoni... | ['Animals', 'Benzazepines', 'Citrulline', 'Dopamine Antagonists', 'Fear', 'Male', 'Nitric Oxide', 'Nucleus Accumbens', 'Rats', 'Rats, Sprague-Dawley', 'Receptors, Dopamine D1'] | 19,340,574 | [['B01.050'], ['D03.633.100.079'], ['D12.125.095.226'], ['D27.505.519.625.150.175', 'D27.505.696.577.150.175'], ['F01.470.361'], ['D01.339.387', 'D01.625.550.500', 'D01.625.700.500', 'D01.650.550.587.600'], ['A08.186.211.200.885.287.249.487.775.500'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.3... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
High-resolution computed tomography of paragangliomas of the head and neck. | High-resolution computed tomography with intravenous contrast enhancement is the initial procedure performed on individuals who present with signs and symptoms of a paraganglioma of the head and neck. Clinical information about these entities is reviewed and technical considerations are discussed. | ['Adult', 'Aged', 'Carotid Body Tumor', 'Diatrizoate Meglumine', 'Ear Neoplasms', 'Female', 'Head and Neck Neoplasms', 'Humans', 'Male', 'Middle Aged', 'Paraganglioma', 'Paraganglioma, Extra-Adrenal', 'Tomography, X-Ray Computed'] | 6,086,236 | [['M01.060.116'], ['M01.060.116.100'], ['C04.557.465.625.650.700.705.220', 'C04.557.580.625.650.700.705.220'], ['D02.033.800.813.550.500', 'D02.241.223.100.400.880.270.500', 'D02.455.426.559.389.127.375.880.270.500', 'D09.067.342.600.500', 'D09.853.813.550.500'], ['C04.588.443.665.312', 'C09.218.334', 'C09.647.312'], [... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Ischemic postconditioning's benefit on reperfusion ventricular arrhythmias is maintained in the senescent heart. | The purpose of this study is to determine if postconditioning's beneficial effect on ventricular arrhythmias is maintained in elderly hearts. In elderly populations, the cardioprotective effects of ischemic preconditioning are lost. Previously, the authors observed that ischemic postconditioning markedly reduced reperf... | ['Aging', 'Animals', 'Arrhythmias, Cardiac', 'Female', 'Ischemic Preconditioning, Myocardial', 'Myocardial Reperfusion Injury', 'Myocardium', 'Rats', 'Rats, Inbred F344'] | 18,495,906 | [['G07.345.124'], ['B01.050'], ['C14.280.067', 'C23.550.073'], ['E02.592.325', 'E05.516.325'], ['C14.280.238.615', 'C14.280.647.625', 'C14.907.585.625', 'C14.907.725.600', 'C23.550.767.877.500'], ['A02.633.580', 'A07.541.704', 'A10.690.552.750'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760.20... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mumps outbreak in the Federation of Bosnia and Herzegovina with large cohorts of susceptibles and genetically diverse strains of genotype G, Bosnia and Herzegovina, December 2010 to September 2012. | A mumps outbreak reported from the Federation of Bosnia and Herzegovina involved 7,895 cases between December 2010 and September 2012. This was the largest outbreak in the country since the introduction of the measles, mumps and rubella vaccine in 1980. The highest disease incidence was found among 15 to 19 year-olds. ... | ['Adolescent', 'Adult', 'Age Distribution', 'Bosnia and Herzegovina', 'Cohort Studies', 'DNA, Viral', 'Disease Outbreaks', 'Female', 'Genotype', 'Hospitalization', 'Humans', 'Immunization', 'Incidence', 'Male', 'Mumps', 'Mumps virus', 'Phylogeny', 'Population Surveillance', 'Reverse Transcriptase Polymerase Chain React... | 25,166,347 | [['M01.060.057'], ['M01.060.116'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['Z01.542.248.160'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['D13.444.308.568'], ['N06.850.290'], ['G05.380'], ['E02.760.400', 'N02.421.585.400'], ['B01.050.150.900.649.313.988.400.112.400.4... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Information Science [L]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
Improved intestinal membrane permeability of hexose-quinoline derivatives via the hexose transporter, SGLT1. | Intestinal membrane permeability is an important factor affecting the bioavailability of drugs. As a strategy to improve membrane permeability, membrane transporters are useful targets since essential nutrients are absorbed efficiently via specific transporters. For example, there are reports that intestinal hexose tra... | ['Animals', 'Biological Transport', 'Glucose', 'Hexoses', 'Humans', 'Intestinal Absorption', 'Male', 'Permeability', 'Quinolines', 'Rats', 'Rats, Wistar', 'Sodium-Glucose Transporter 1', 'Xenopus'] | 17,828,732 | [['B01.050'], ['G03.143'], ['D09.947.875.359.448'], ['D09.947.875.359'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G03.015.500.374.500', 'G03.787.024.500.374.500', 'G07.203.650.372.500', 'G07.690.725.015.500.374.500', 'G10.261.353.500'], ['G02.723'], ['D03.633.100.810'], ['B01.050.150.900.649.313.992.635.505.7... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Screening of Inflammatory Bowel Disease and Spondyloarthritis for Referring Patients Between Rheumatology and Gastroenterology. | OBJECTIVE: To define clinical screening criteria for spondyloarthritis (SpA) in patients with inflammatory bowel disease (IBD) and vice versa, which can be used as a reference for referring them to the rheumatology or gastroenterology service.METHOD: Systematic literature review and a two-round Delphi method. The scien... | ['Delphi Technique', 'Early Diagnosis', 'Gastroenterology', 'Humans', 'Inflammatory Bowel Diseases', 'Referral and Consultation', 'Rheumatology', 'Spondylarthritis'] | 28,784,316 | [['L01.906.197'], ['E01.390'], ['H02.403.429.405'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C06.405.205.731', 'C06.405.469.432'], ['N04.452.758.849'], ['H02.403.429.730'], ['C05.116.900.853.625', 'C05.550.114.865']] | ['Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Chick HoxB3: deduced amino-acid sequence and embryonic gene expression. | The deduced amino-acid sequence of chick HoxB3 shows 70% homology to the murine HoxB3. The major difference is that the chick sequence lacks a run of Gly residues present in mouse and human HoxB3. The basic pattern of expression of HoxB3 in the embryonic nervous system is conserved between mice and chicks. | ['Amino Acid Sequence', 'Animals', 'Chick Embryo', 'Chickens', 'Codon', 'DNA-Binding Proteins', 'Gene Expression', 'Genes, Homeobox', 'Homeodomain Proteins', 'Hominidae', 'Humans', 'In Situ Hybridization', 'Mice', 'Molecular Sequence Data', 'Rhombencephalon', 'Sequence Homology, Amino Acid', 'Xenopus Proteins'] | 7,959,024 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['A13.350.150', 'A16.331.200'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['D13.444.735.544.355', 'G05.360.335.355', 'G05.360.340.024.340.137.190'], ['D12.776.260'], ['G05.297'], ['G05.360.340.024.340.230.500'], ['D12.776.260.400'], ['B01.0... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Extranuclear estrogen-regulated destabilization of Xenopus laevis serum albumin mRNA. | The present study examined 1) whether the estrogen-regulated destabilization of albumin mRNA occurs in the nuclear or extranuclear fraction of the liver cell, and 2) whether the selective posttranscriptional regulation of albumin mRNA stability might result from covalent changes introduced in the processing or polyaden... | ['Animals', 'Base Sequence', 'Blotting, Northern', 'Cell Nucleus', 'Cloning, Molecular', 'Endoribonucleases', 'Estradiol', 'Liver', 'Male', 'Molecular Sequence Data', 'Plasmids', 'RNA, Messenger', 'Ribonuclease H', 'Serum Albumin', 'Transcription, Genetic', 'Xenopus laevis'] | 2,547,154 | [['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.196.401.095', 'E05.301.300.074', 'E05.601.100'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['E05.393.220'], ['D08.811.277.352.355.350', 'D08.811.277.352.700.350'], ['D04.210.500.365.415.248', 'D06.472.334.851.437.500'], ['A03.620']... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Modeling of the anticancer action for radical derivatives of nitroazoles: quantitative structure-activity relationship (QSAR) study. | A QSAR analysis of the anti-tumor, anti-metastasis and anti-colony formation (for metastatic colonies) activities of eighteen nitroazoles (including metronidazole and hypoxic radiosensitizers RP-170, KU-2285 and sanazole (drug AK-2123)) and their nitro and nitroso anion radical derivatives against melanoma B16 in mice ... | ['Animals', 'Antineoplastic Agents', 'Azoles', 'Colony-Forming Units Assay', 'Free Radicals', 'Melanoma, Experimental', 'Mice', 'Models, Molecular', 'Nitro Compounds', 'Quantitative Structure-Activity Relationship'] | 12,030,113 | [['B01.050'], ['D27.505.954.248'], ['D03.383.129'], ['E01.370.225.500.383', 'E05.200.500.383', 'E05.242.383'], ['D01.339', 'D02.389'], ['C04.557.465.625.650.510.525', 'C04.557.580.625.650.510.525', 'C04.557.665.510.525', 'C04.619.600', 'E05.598.500.496.937'], ['B01.050.150.900.649.313.992.635.505.500'], ['E05.599.595']... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Efficacy and safety of digital subtraction angiography with special reference to contrast agents. | We evaluated the diagnostic accuracy and complications of digital subtraction angiography (DSA) in a series of clinical trials conducted on patients primarily with cerebral vascular disease and those evaluated before and after surgery or percutaneous transluminal angioplasty. Double-blind studies of the carotid-vertebr... | ['Angiography', 'Catheterization', 'Cerebrovascular Disorders', 'Clinical Trials as Topic', 'Contrast Media', 'Double-Blind Method', 'Humans', 'Subtraction Technique'] | 6,360,367 | [['E01.370.350.700.060', 'E01.370.370.050'], ['E02.148', 'E05.157'], ['C10.228.140.300', 'C14.907.253'], ['E05.318.372.250.250', 'N05.715.360.330.250.250', 'N06.850.520.450.250.250'], ['D27.505.259.500', 'D27.720.259'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['B01.050.150.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Suppression of neuropeptide Y1 receptor function in SK-N-MC cells by nitric oxide. | The neuropeptide Y1 receptor (NPY1) predominantly mediates the vasoconstrictor effects of NPY in smooth muscle cells. The present experiments were planned to study the direct influence of the vasodilator nitric oxide (NO) on NPY1-receptor function. SK-N-MC and CHP-234 cells expressing Y1 and Y2 receptor, respectively, ... | ['Blotting, Northern', 'Cyclic AMP', 'Molsidomine', 'Nitric Oxide', 'Nitroprusside', 'Penicillamine', 'RNA, Messenger', 'Receptors, Neuropeptide Y', 'S-Nitroso-N-Acetylpenicillamine', 'Tumor Cells, Cultured', 'Vasodilator Agents'] | 9,277,359 | [['E05.196.401.095', 'E05.301.300.074', 'E05.601.100'], ['D03.633.100.759.646.138.395', 'D13.695.462.200', 'D13.695.667.138.395', 'D13.695.827.068.395'], ['D03.383.129.462.580.693.450', 'D03.383.533.640.362'], ['D01.339.387', 'D01.625.550.500', 'D01.625.700.500', 'D01.650.550.587.600'], ['D01.248.497.158.291.350.550', ... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
RHCE-D-CE hybrid genes can cause false-negative DNA typing of the Rh e antigen. | BACKGROUND AND OBJECTIVES: DNA typing of the human Rh blood groups generally shows good agreement with serologically defined phenotypes. However, in the present report we describe four individuals who were declared Rh e negative by genotyping although they express the Rh e antigen.MATERIALS AND METHODS: Serotyping was ... | ['Blood Grouping and Crossmatching', 'Epitopes', 'False Negative Reactions', 'Gene Rearrangement', 'Genotype', 'Glycoproteins', 'Humans', 'Pedigree', 'Rh-Hr Blood-Group System'] | 12,366,772 | [['E01.370.225.625.120', 'E01.370.225.812.385.120', 'E05.200.625.120', 'E05.200.812.385.120', 'E05.478.594.385.120'], ['D23.050.550'], ['E01.354.340'], ['G05.344'], ['G05.380'], ['D09.400.430', 'D12.776.395'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.393.673'], ['D23.050.301.290.775', 'D23.050.705.230.775... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Homozygous inactivation of the NF1 gene in bone marrow cells from children with neurofibromatosis type 1 and malignant myeloid disorders. | BACKGROUND: The risk of malignant myeloid disorders in young children with neurofibromatosis type 1 is 200 to 500 times the normal risk. The gene for neurofibromatosis type 1 (NF1) encodes neurofibromin, a protein that negatively regulates signals transduced by Ras proteins. Genetic and biochemical data support the hyp... | ['Bone Marrow', 'Child', 'Child, Preschool', 'Female', 'Gene Expression Regulation, Neoplastic', 'Homozygote', 'Humans', 'Infant', 'Leukemia, Myeloid', 'Male', 'Mutation', 'Myelodysplastic Syndromes', 'Neurofibromatosis 1', 'Neurofibromin 1', 'Proteins'] | 9,180,088 | [['A15.382.216'], ['M01.060.406'], ['M01.060.406.448'], ['G05.308.370'], ['G05.380.554'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['C04.557.337.539'], ['G05.365.590'], ['C15.378.190.625'], ['C04.557.580.600.580.590.650', 'C04.700.631.650', 'C10.562.600.500', 'C10.574.500.549.400', 'C10.668.829... | ['Anatomy [A]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Simple noninvasive method to test efficacy of drugs in the eradication of Helicobacter pylori infection: the example of combined bismuth subsalicylate and nitrofurantoin. | Eradication of Helicobacter pylori infections has proved to be difficult. There is a need both for improved therapies and for ways to rapidly identify therapies that show sufficient promise to be worth pursuing. The objectives of this study were to evaluate the value of a therapeutic regimen of a bismuth salt plus nitr... | ['Adult', 'Bismuth', 'Breath Tests', 'Drug Therapy, Combination', 'Enzyme-Linked Immunosorbent Assay', 'Gastritis', 'Helicobacter Infections', 'Helicobacter pylori', 'Humans', 'Male', 'Middle Aged', 'Nitrofurantoin', 'Organometallic Compounds', 'Salicylates', 'Urea'] | 1,882,794 | [['M01.060.116'], ['D01.268.271.245', 'D01.268.556.100', 'D01.496.749.305.245', 'D01.552.544.100'], ['E01.370.100'], ['E02.319.310'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['C06.405.205.697', 'C06.405.748.398'], ['C01.150.252.400.466'], ['B0... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The experience of lower limb lymphedema for women after treatment for gynecologic cancer. | PURPOSE/OBJECTIVES: To describe women's experiences with lower limb lymphedema to inform both preventive and management clinical practices.DESIGN: A retrospective survey.SETTING: The gynecology/oncology unit of a tertiary referral women's hospital in Australia.SAMPLE: 82 women who developed lower limb lymphedema after ... | ['Adaptation, Psychological', 'Bandages', 'Clothing', 'Cohort Studies', 'Female', 'Genital Neoplasms, Female', 'Humans', 'Interviews as Topic', 'Leg', 'Life Style', 'Lymphedema', 'Pain', 'Patient Education as Topic', 'Physical Therapy Modalities', 'Population Surveillance', 'Quality of Life', 'Referral and Consultation... | 12,719,742 | [['F01.058'], ['E07.101'], ['J01.637.215'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['C04.588.945.418', 'C13.351.937.418'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.420', 'L01.399.250.520', 'N05.715.360.300.400', 'N06.850.520.308.420'], ['A01.378.610.500'], [... | ['Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Information Science [L]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Soc... | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 |
Evaluation of surgical gamma probes for sentinel node localization in cervical and vulvar cancer. | BACKGROUND: Sentinel node (SN) scintigraphy for cervical and vulvar cancer guides the gynaecological oncologist in finding the metastatic lymph nodes during lymphadenectomy. The role of the surgical gamma probe in the sentinel node concept in gynaecological oncology is to localise (SN) both intra-operatively and transc... | ['Equipment Design', 'Equipment Failure Analysis', 'Female', 'Gamma Cameras', 'Humans', 'Lymph Node Excision', 'Lymph Nodes', 'Lymphatic Metastasis', 'Phantoms, Imaging', 'Radionuclide Imaging', 'Reproducibility of Results', 'Sensitivity and Specificity', 'Sentinel Lymph Node Biopsy', 'Surgery, Computer-Assisted', 'Ute... | 16,437,395 | [['E05.320'], ['E05.325.192'], ['E07.420'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.446'], ['A10.549.400', 'A15.382.520.604.412'], ['C04.697.650.560', 'C23.550.727.650.560'], ['E07.671'], ['E01.370.350.710', 'E01.370.384.730'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.72... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
The Cost of Asthma Treatment in Phramongkutlao Hospital: Population-Based Study in Adults. | BACKGROUND: Asthma is a chronic respiratory disease that affects patients' quality of life and work performance. The cost of asthma treatment is a global economic burden. The costs include the direct medical costs and the indirect costs, such as the loss of productivity, which is difficult to quantify.OBJECTIVE: Analyz... | ['Adolescent', 'Adult', 'Aged', 'Anti-Asthmatic Agents', 'Asthma', 'Cost of Illness', 'Disease Progression', 'Drug Costs', 'Efficiency', 'Female', 'Health Care Costs', 'Health Expenditures', 'Hospitals', 'Humans', 'Male', 'Middle Aged', 'Quality of Life', 'Research Design', 'Surveys and Questionnaires', 'Thailand', 'Yo... | 27,455,824 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.796.050'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['N03.219.151.165', 'N05.715.360.300.800.438.375.182', 'N06.850.520.308.980.438.475.046'], ['C23.550.291.656'], ['N03.219.151.400.350', 'N05.300.375.300'], ['F02.784... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'... | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Treatment of early mixed cellular and humoral renal allograft rejection with tacrolimus and mycophenolate mofetil. | This prospective study investigated the efficiency of the tacrolimus (Tac) combined with mycophenolate mofetil (MMF) alone without immunoadsorption (IA) or plasmapheresis (PPH) as treatment for early (within 2 weeks) acute humoral rejection (AHR) in non-sensitized renal allograft recipients. Of 160 patients enrolled in... | ['Acute Disease', 'Adult', 'Female', 'Graft Rejection', 'Humans', 'Immunity, Cellular', 'Immunosuppressive Agents', 'Isoantibodies', 'Kidney Transplantation', 'Male', 'Middle Aged', 'Mycophenolic Acid', 'Prospective Studies', 'Tacrolimus'] | 16,969,384 | [['C23.550.291.125'], ['M01.060.116'], ['G12.875.545.328'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G12.450.050.400'], ['D27.505.696.477.656'], ['D12.776.124.486.485.114.664', 'D12.776.124.790.651.114.664', 'D12.776.377.715.548.114.664'], ['E02.870.500', 'E04.936.450.485', 'E04.950.774.400'], ['M01.060.116.6... | ['Diseases [C]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Node counts in neck dissection: are they useful in outcomes research? | OBJECTIVES: We studied the unilateral nodal yields for procedures reported as standard or modified radical neck dissection (RND) to determine their applicability in outcomes research.METHODS: We analyzed the unilateral nodal yields for all procedures reported as RND for carcinoma of the oral cavity, pharynx, and larynx... | ['Carcinoma, Squamous Cell', 'Humans', 'Laryngeal Neoplasms', 'Lymph Nodes', 'Neck', 'Neck Dissection', 'Oropharyngeal Neoplasms', 'Retrospective Studies'] | 11,283,502 | [['C04.557.470.200.400', 'C04.557.470.700.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.443.665.481', 'C08.360.369', 'C08.785.481', 'C09.400.369', 'C09.647.481'], ['A10.549.400', 'A15.382.520.604.412'], ['A01.598'], ['E04.446.318', 'E04.580.411'], ['C04.588.443.665.710.684', 'C07.550.745.671', 'C09.... | ['Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Maternally transmitted HIV infection in children. | We evaluated 16 children at high risk for AIDS because of mothers infected with HIV. Two children were persistently seropositive and had laboratory and clinical evidence of HIV infection but had no detectable infectious HIV in their peripheral blood mononuclear cells (PBMC). Seven children, all of whom had clinical and... | ['Acquired Immunodeficiency Syndrome', 'Child', 'Child, Preschool', 'Diagnostic Errors', 'Female', 'HIV', 'HIV Antibodies', 'HIV Seropositivity', 'Humans', 'Infant', 'Infant, Newborn', 'Leukocytes, Mononuclear', 'Pregnancy', 'Pregnancy Complications, Infectious'] | 3,149,491 | [['C01.221.250.875.040', 'C01.221.812.640.400.040', 'C01.778.640.400.040', 'C01.925.782.815.616.400.040', 'C01.925.813.400.040', 'C01.925.839.040', 'C20.673.480.040'], ['M01.060.406'], ['M01.060.406.448'], ['E01.354', 'N02.421.450.280'], ['B04.820.650.589.650.350'], ['D12.776.124.486.485.114.254.150.440', 'D12.776.124.... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
High frequency of herpesvirus-specific clonotypes in the human T cell repertoire can remain stable over decades with minimal turnover. | High-throughput T cell receptor sequencing on sequentially banked blood samples from healthy individuals has shown that high-frequency clonotypes can remain relatively stable for up to 18 years, with minimal inflation, deflation, or turnover. These populations included T cell expansions specific for Epstein-Barr virus.... | ['Adult', 'Aged', 'Amino Acid Sequence', 'Blood Donors', 'Genetic Variation', 'Humans', 'Male', 'Middle Aged', 'Molecular Sequence Data', 'Receptors, Antigen, T-Cell', 'Receptors, Virus', 'Sequence Analysis, DNA', 'T-Lymphocytes', 'Time Factors'] | 23,077,319 | [['M01.060.116'], ['M01.060.116.100'], ['G02.111.570.060', 'L01.453.245.667.060'], ['M01.898.313'], ['G05.365'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['L01.453.245.667'], ['D12.776.543.750.705.816.824'], ['D12.776.543.750.830'], ['E05.393.760.700'], ['A11.118.637.555.567.569', 'A15.145.... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
[Study on SPAD visualization of pumpkin leaves based on hyperspectral imaging technology]. | Visible/near-infrared (380 approximately 1 030 nm) hyperspectral imaging technique was used to realize SPAD visualization of pumpkin leaves in the present study. Downy mildew could be diagnosed rapidly according to significant positive correlation between downy mildew epidemic and chlorophyll content. Leaves uninfected... | ['Chlorophyll', 'Cucurbita', 'Least-Squares Analysis', 'Models, Theoretical', 'Plant Diseases', 'Plant Leaves', 'Spectroscopy, Near-Infrared'] | 25,095,442 | [['D03.383.129.578.840.374', 'D03.633.400.909.374', 'D04.345.783.374'], ['B01.650.940.800.575.912.250.300.222'], ['E05.318.740.750.400', 'N05.715.360.750.695.440', 'N06.850.520.830.750.400'], ['E05.599'], ['G15.610'], ['A18.024.812'], ['E01.370.350.750', 'E05.196.867.851']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Multiple, discrete 35S transcripts of cauliflower mosaic virus. | We have devised a modification of the Berk and Sharp procedure that allows us to detect the presence of a diverse population of 35S full-length, genomic viral transcripts of cauliflower mosaic virus (CaMV). Using this procedure we have been able to identify and characterize four such 35S transcripts. The first 35S RNA ... | ['Base Sequence', 'DNA, Viral', 'Endonucleases', 'Mosaic Viruses', 'Nucleic Acid Hybridization', 'RNA, Fungal', 'RNA, Viral', 'Transcription, Genetic', 'Yeasts'] | 6,319,527 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D13.444.308.568'], ['D08.811.277.352.355'], ['B04.715.464'], ['E05.393.661', 'G02.111.611'], ['D13.444.735.500'], ['D13.444.735.828'], ['G02.111.873', 'G05.297.700'], ['B01.300.930']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Impact of sleep disturbances on PTSD symptoms and perceived health. | More than two-thirds of individuals with PTSD report significant sleep difficulties that correlate positively with PTSD symptom severity. The aim of the study was to assess the impact of sleep disturbances on PTSD symptom severity and perceived health. Ninety-two volunteer treatment-seeking adults with PTSD were admini... | ['Adolescent', 'Adult', 'Aged', 'Alcoholism', 'Attitude to Health', 'Comorbidity', 'Cross-Sectional Studies', 'Dreams', 'Female', 'Humans', 'Male', 'Middle Aged', 'Parasomnias', 'Personality Inventory', 'Psychometrics', 'Quality of Life', 'Sleep Initiation and Maintenance Disorders', 'Stress Disorders, Post-Traumatic',... | 19,214,048 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['C25.775.100.250', 'F03.900.100.350'], ['F01.100.150', 'N05.300.150'], ['N05.715.350.225', 'N06.850.490.687'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['F02.463.188.634.309', 'F02.830.855.268'], ['B01.050.150.900.649.313.988... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Unilateral phacoemulsification and intraocular lens implantation in a dachshund. | A 1.5-year-old, spayed, female dachshund was presented with a cataract and lens-induced uveitis in the left eye. The cataract progressed from immature to hypermature in 4 months. Phacoemulsification and intraocular lens implantation was performed and the dog remains visual in the left eye 1 year post-surgery. | ['Animals', 'Cataract', 'Dog Diseases', 'Dogs', 'Female', 'Lens Implantation, Intraocular', 'Phacoemulsification', 'Treatment Outcome', 'Uveitis', 'Visual Acuity'] | 19,119,375 | [['B01.050'], ['C11.510.245'], ['C22.268'], ['B01.050.150.900.649.313.750.250.216.200'], ['E04.540.825.600'], ['E04.540.825.249.704', 'E04.943.875'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800'], ['C11.941.879'], ['E01.370.380.850.950', 'F02.463.593.932.901', 'G14.940']] | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
DMSO modifies structural and functional properties of RPMI-8402 cells by promoting programmed cell death. | Apoptosis in lymphoid cells can be induced in different ways depending on cell type and acquired signal. Biochemical modifications occur at an early phase of cell death while at late times the typical morphological features of apoptosis can be visualized. The aim of this study is to verify by multiparametric analyses t... | ['Apoptosis', 'Calcium', 'Cell Line, Tumor', 'Cell Membrane', 'Dimethyl Sulfoxide', 'Humans', 'Intracellular Fluid', 'Nitric Oxide Synthase', 'T-Lymphocytes'] | 14,611,729 | [['G04.146.954.035'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['A11.251.210.190', 'A11.251.860.180'], ['A11.284.149'], ['D02.886.640.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.284.430.429', 'A11.284.835.450', 'A12.207.515'], ['D08.811.682.664.500.772'], ['A11.118.637.555.567.569', 'A15... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Tailoring the specificity of a plant cystatin toward herbivorous insect digestive cysteine proteases by single mutations at positively selected amino acid sites. | Plant cystatins, similar to other defense proteins, include hypervariable, positively selected amino acid sites presumably impacting their biological activity. Using 29 single mutants of the eighth domain of tomato (Solanum lycopersicum) multicystatin, SlCYS8, we assessed here the potential of site-directed mutagenesis... | ['Animals', 'Coleoptera', 'Cystatins', 'Cysteine Proteinase Inhibitors', 'Food Chain', 'Heteroptera', 'Host-Parasite Interactions', 'Lycopersicon esculentum', 'Mutagenesis, Site-Directed'] | 18,192,440 | [['B01.050'], ['B01.050.500.131.617.720.500.500.375'], ['D12.776.215'], ['D27.505.519.389.745.325'], ['G16.500.275.157.250', 'N06.230.124.250'], ['B01.050.500.131.617.412.420'], ['G16.527.200.400'], ['B01.650.940.800.575.912.250.908.500.322'], ['E05.393.420.601.575']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Rural Zulu women's knowledge of and attitudes towards medical male circumcision. | BACKGROUND: Medical male circumcision (MMC) is a key strategy in the South African HIV infection prevention package. Women may have a potentially powerful role in supporting such a strategy. Circumcision is not a traditional part of Zulu society, and Zulu women may have limited knowledge and ambivalent or negative atti... | ['Adult', 'African Continental Ancestry Group', 'Circumcision, Male', 'Cross-Sectional Studies', 'Culture', 'Female', 'HIV Infections', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Male', 'Nuclear Family', 'Pregnancy', 'Pregnant Women', 'Qualitative Research', 'Rural Population', 'Sexual Partners', 'South Africa... | 26,245,595 | [['M01.060.116'], ['M01.686.508.100'], ['E02.218.085.170', 'E04.085.170', 'E04.950.774.860.226'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['I01.076.201.450', 'I01.880.853.100'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.4... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Geographica... | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Intracardiac blood flow velocities and cardiac output in normal fetuses: a prospective pulsed Doppler echocardiographic study. | Two dimensional and pulsed Doppler echocardiographic studies were performed in human fetuses with the aim to establish normal values for blood flow velocities and cardiac output in Indian subjects. Thirteen pregnant mothers were prospectively followed up at 4 weeks interval from 19 to 40 weeks of gestation. Blood flow ... | ['Blood Flow Velocity', 'Cardiac Output', 'Coronary Circulation', 'Echocardiography, Doppler', 'Female', 'Fetus', 'Humans', 'Pregnancy', 'Prospective Studies', 'Ultrasonography, Prenatal'] | 1,307,090 | [['E01.370.370.130', 'G09.330.380.630.080'], ['E01.370.370.380.150', 'G09.330.380.124'], ['G09.330.100.324'], ['E01.370.350.130.750.220', 'E01.370.350.850.220.220', 'E01.370.350.850.850.220', 'E01.370.370.380.220.220'], ['A16.378'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G08.686.784.769'], ['E05.318.372.500... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Effect of cardiac and respiratory cycles on vertebral heart score measured on fluoroscopic images of healthy dogs. | OBJECTIVE: To assess the variability in vertebral heart score (VHS) measurement induced by cardiac and respiratory cycles in dogs.DESIGN: Prospective observational study.ANIMALS: 14 healthy Beagles.PROCEDURES: Dogs underwent fluoroscopic examination by 4 observers, and VHS was measured at end-tidal inspiration and end-... | ['Animals', 'Dogs', 'Female', 'Fluoroscopy', 'Heart', 'Lung', 'Male', 'Posture', 'Prospective Studies', 'Radiography, Thoracic', 'Reference Values'] | 25,932,934 | [['B01.050'], ['B01.050.150.900.649.313.750.250.216.200'], ['E01.370.350.700.225'], ['A07.541'], ['A04.411'], ['G11.427.695'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['E01.370.350.700.730'], ['E05.978.810']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Regulation of Agrobacterium tumefaciens T-cyt gene expression in leaves of transgenic potato (Solanum tuberosum L. cv. D?sir?e) is strongly influenced by plant culture conditions. | The promoter region of the Agrobacterium tumefaciens T-cyt gene was linked in a translational fusion to the coding DNA of the reporter gene uidA (for beta-glucuronidase or GUS protein; EC 3.2.1.31) and to nos 3' flanking DNA. The chimaeric gene was introduced by Agrobacterium transformation into potato (Solanum tuberos... | ['Agrobacterium tumefaciens', 'Alkyl and Aryl Transferases', 'Culture Techniques', 'Gene Expression Regulation', 'Glucuronidase', 'Mutation', 'Phenotype', 'Plants, Genetically Modified', 'Plasmids', 'Promoter Regions, Genetic', 'Recombinant Fusion Proteins', 'Solanum tuberosum', 'Transferases', 'Transformation, Genetic... | 1,912,495 | [['B03.440.400.425.700.024.050', 'B03.660.050.662.024.500'], ['D08.811.913.225'], ['E05.481.500'], ['G05.308'], ['D08.811.277.450.426'], ['G05.365.590'], ['G05.695'], ['B01.650.520', 'B05.620.600'], ['G05.360.600'], ['G02.111.570.080.689.675', 'G05.360.080.689.675', 'G05.360.340.024.340.137.750.680'], ['D12.776.828.300... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Factors Influencing the Early Development of World-Class Caribbean Track and Field Athletes: A Qualitative Investigation. | This qualitative investigation sought to explore through a socio-cultural lens the perceived early training and competition environment, and support network of world-class Caribbean track and field athletes and the influence on their sport engagement and progression during early childhood and adolescence. Sixteen world... | ['Adolescent', 'Adult', 'Aptitude', 'Competitive Behavior', 'Cultural Characteristics', 'Family', 'Female', 'Financial Support', 'Humans', 'Male', 'Mentors', 'Motivation', 'Peer Group', 'Play and Playthings', 'Qualitative Research', 'Social Support', 'Track and Field', 'West Indies', 'Young Adult'] | 31,827,361 | [['M01.060.057'], ['M01.060.116'], ['F02.784.629.131'], ['F01.145.813.105'], ['I01.076.201.450.324', 'I01.880.853.100.329'], ['F01.829.263', 'I01.880.853.150'], ['N03.219.483'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.395'], ['F01.658', 'F01.752.543.500.750'], ['F01.829.316.483'], ['I03.450.642.693'], ['... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Vitamin D levels and markers of arterial dysfunction in HIV. | HIV-infected patients have low vitamin D levels as well as an increase in cardiovascular (CVD) risk. We examined the relationship between vitamin D and three markers of arterial dysfunction among HIV-infected individuals on stable antiretroviral (ARV) therapy. Levels of 25-hydroxyvitamin D [25(OH)D] were assessed by ch... | ['Anti-Retroviral Agents', 'Arteries', 'Biomarkers', 'Cohort Studies', 'HIV Infections', 'Hawaii', 'Humans', 'Longitudinal Studies', 'Male', 'Middle Aged', 'Risk Factors', 'Vascular Diseases', 'Vitamin D'] | 21,978,287 | [['D27.505.954.122.388.077'], ['A07.015.114'], ['D23.101'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['Z01.107.567.875.580.375', 'Z01.639.760.815.482'], ['B01... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Geographicals [Z]', 'Organisms [B]', 'Named Groups [M]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Perceptions of Institutional Betrayal Predict Suicidal Self-Directed Violence Among Veterans Exposed to Military Sexual Trauma. | OBJECTIVES: We examined perceptions of institutional betrayal among Veterans exposed to military sexual trauma (MST) and whether perceptions of institutional betrayal are associated with symptoms of posttraumatic stress disorder (PTSD), depression, and suicidal ideation and attempt after MST.METHOD: A total of 49 Veter... | ['Adult', 'Female', 'Humans', 'Male', 'Middle Aged', 'Military Personnel', 'Organizational Culture', 'Psychological Trauma', 'Sex Offenses', 'Stress Disorders, Post-Traumatic', 'Suicidal Ideation', 'Suicide, Attempted', 'United States', 'United States Department of Defense', 'Veterans'] | 27,007,795 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['M01.526.625'], ['N04.452.606'], ['F03.950.750.375'], ['I01.198.240.748'], ['F03.950.750.500'], ['F01.145.126.980.875.149', 'I01.880.735.856.149'], ['F01.145.126.980.875.600', 'I01.880.735.856.600'], ['Z01.107.567.875'], ['I01.409.... | ['Named Groups [M]', 'Organisms [B]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
SUSD2 promotes cancer metastasis and confers cisplatin resistance in high grade serous ovarian cancer. | The activation of Notch3 is associated with potential progression of ovarian cancer, tumor invasion, metastasis and chemoresistance, which account for poor prognosis of high grade serous ovarian cancer (HGSOC). However, the underlying mechanisms of Notch3 are not yet very clear. Here we show that SUSD2 is one of Notch3... | ['Cell Line, Tumor', 'Cell Movement', 'Cisplatin', 'Drug Resistance, Neoplasm', 'Epithelial-Mesenchymal Transition', 'Female', 'Gene Expression Regulation, Neoplastic', 'Humans', 'Membrane Glycoproteins', 'Neoplasm Grading', 'Neoplasm Metastasis', 'Ovarian Neoplasms', 'Ovary'] | 29,305,171 | [['A11.251.210.190', 'A11.251.860.180'], ['G04.198', 'G07.568.500.180'], ['D01.210.375', 'D01.625.125', 'D01.710.100'], ['G07.690.773.984.395'], ['G04.356.500'], ['G05.308.370'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.395.550', 'D12.776.543.550'], ['E01.789.612'], ['C04.697.650', 'C23.550.727.650'],... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of Renal Denervation on Insulin Sensitivity and Inflammatory Markers in Nondiabetic Patients with Treatment-Resistant Hypertension. | Increased sympathetic activity is important in the pathogenesis of hypertension and insulin resistance. Afferent signaling from the kidneys elevates the central sympathetic drive. We investigated the effect of catheter-based renal sympathetic denervation (RDN) on glucose metabolism, inflammatory markers, and blood pres... | ['Adult', 'Aged', 'Antihypertensive Agents', 'Biomarkers', 'Blood Glucose', 'Blood Pressure', 'Catheter Ablation', 'Drug Resistance', 'Female', 'Glycated Hemoglobin A', 'Humans', 'Hypertension', 'Inflammation Mediators', 'Insulin', 'Insulin Resistance', 'Kidney', 'Male', 'Middle Aged', 'Renal Artery', 'Sympathectomy', ... | 29,082,259 | [['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.411.162'], ['D23.101'], ['D09.947.875.359.448.500'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E02.808.750.500', 'E04.014.760.500'], ['G07.690.773.984'], ['D09.400.430.937', 'D12.776.124.400.405.440', 'D12.776.395.381', 'D12.776.422.316.762.380.440'], ['B01.050.1... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
What good are we doing? The role of clinical research in enhancing critical care medicine. | The amount of financial and other resources used by physicians in the treatment of critically ill patients makes it incumbent upon physicians to ensure that sufficient benefit is obtained from these resources and that physicians are in fact doing good for their patients. Knowing that one is in fact doing good requires ... | ['Attitude of Health Personnel', 'Critical Care', 'Ethics, Medical', 'Health Priorities', 'Health Services Needs and Demand', 'Humans', 'Interdisciplinary Communication', 'Moral Obligations', 'Organizational Objectives', 'Patient Advocacy', 'Patient Care Team', 'Patient Selection', 'Philosophy, Medical', 'Physicians', ... | 8,305,961 | [['F01.100.050', 'N05.300.100'], ['E02.760.190', 'N02.421.585.190'], ['K01.752.566.479.171.132.750', 'N05.350.340.162.500'], ['N03.349.330', 'N05.300.400'], ['N03.349.380.420', 'N05.300.450'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.401.205.249', 'L01.143.865.500'], ['F01.829.500.760.500', 'K01.752.5... | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Humanities [K]', 'Organisms [B]', 'Information Science [L]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Named Groups [M]', 'Disciplines and Occupations [H]', 'Phenomena and... | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 |
An in silico stereo-electronic comparison of conventional pyridinium oximes and K-oximes for organophosphate (OP) poisoning. | A comparative analysis of stereo-electronic properties of five cholinesterase reactivators (pralidoxime (2- PAM), trimedoxime, obidoxime, HI-6, and HLo-7) and six "K-oximes" was performed to assess their roles in reactivating OP-inhibited phosphorylated serine residue of mouse AChE. Quantum mechanical (QM) calculations... | ['Acetylcholinesterase', 'Animals', 'Cholinesterase Inhibitors', 'Electrons', 'Mice', 'Models, Molecular', 'Molecular Structure', 'Organophosphate Poisoning', 'Organophosphorus Compounds', 'Oximes', 'Phosphorylation', 'Pyridinium Compounds', 'Quantum Theory', 'Stereoisomerism', 'Structure-Activity Relationship'] | 22,385,173 | [['D08.811.277.352.100.170.176'], ['B01.050'], ['D27.505.519.389.275', 'D27.505.519.625.120.300', 'D27.505.696.577.120.300'], ['G01.249.335', 'G01.358.500.750'], ['B01.050.150.900.649.313.992.635.505.500'], ['E05.599.595'], ['G02.111.570', 'G02.466'], ['C25.723.717'], ['D02.705'], ['D02.092.570.665'], ['G02.111.665', '... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Enumeration of Mycobacterium leprae using real-time PCR. | Mycobacterium leprae is not cultivable in axenic media, and direct microscopic enumeration of the bacilli is complex, labor intensive, and suffers from limited sensitivity and specificity. We have developed a real-time PCR assay for quantifying M. leprae DNA in biological samples. Primers were identified to amplify a s... | ['Animals', 'Calibration', 'DNA, Bacterial', 'DNA, Ribosomal', 'Escherichia coli', 'Hindlimb', 'Mice', 'Mice, Nude', 'Mycobacterium leprae', 'Polymerase Chain Reaction', 'RNA, Ribosomal, 16S', 'Staphylococcus epidermidis', 'Streptococcus pyogenes'] | 18,982,056 | [['B01.050'], ['E05.978.155'], ['D13.444.308.212'], ['D13.444.308.475'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['A13.473'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.150.900.649.313.992.635.505.500.550.500'], ['B03.510.024.962.500.502', 'B03.510.460.400.410.552.552.502'], ['E05.393.620.50... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Identifying Sensitive Periods for Alcohol Use: The Roles of Timing and Chronicity of Child Physical Abuse. | BACKGROUND: Childhood maltreatment, particularly physical abuse (PA), increases the risk of alcohol use during young adulthood. Although prior research underscores the importance of examining the roles of PA-event characteristics such as timing of and chronicity of PA in initiating and maintaining alcohol use, few stud... | ['Adolescent', 'Adult', 'Adult Survivors of Child Abuse', 'Alcohol Drinking', 'Alcohol-Related Disorders', 'Alcoholism', 'Binge Drinking', 'Critical Period, Psychological', 'Female', 'Humans', 'Male', 'Time Factors', 'Young Adult'] | 27,079,899 | [['M01.060.057'], ['M01.060.116'], ['M01.135.500', 'M01.860.300.500'], ['F01.145.317.269'], ['C25.775.100', 'F03.900.100'], ['C25.775.100.250', 'F03.900.100.350'], ['C25.775.100.437', 'F01.145.317.269.500', 'F03.900.100.550'], ['F02.463.425.209'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.910.857'], ['M01.... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The role of potassium and sodium-calcium exchange currents in the action potential durations of normal Purkinje fibres and Purkinje fibres surviving infarction. | Ventricular arrhythmias following myocardial infarction may originate from subendocardial Purkinje fibres in the infarcted area. The role of potassium and sodium-calcium exchange currents on action potential duration was therefore investigated in Purkinje fibres surviving infarction and in normal Purkinje fibres. Bariu... | ['Action Potentials', 'Animals', 'Barium', 'Biological Transport', 'Calcium', 'Chlorides', 'Dogs', 'Female', 'Heart Conduction System', 'Ion Channels', 'Lidocaine', 'Lithium', 'Lithium Chloride', 'Male', 'Myocardial Infarction', 'Potassium', 'Purkinje Fibers', 'Sodium'] | 2,482,131 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['B01.050'], ['D01.268.552.050', 'D01.268.556.062', 'D01.552.539.124', 'D01.552.544.062'], ['G03.143'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D01.210.450.150', 'D01.248.497.158.215'], ['B01.050.150.900.649.313.750.250.216.200'], ['A07.541.409'],... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Genomic structure, alternative transcripts and chromosome location of the human LIM domain binding protein 1 gene LDB1. | By protein interaction screening using a radioactive LMO2 protein probe we have isolated a LIM domain binding protein. The gene shows high homology to independently isolated genes from mouse, Xenopus and Drosophila called Ldb1/Nli/Clim-2, Xldb1 and Chip, respectively. The human and mouse genes differ by only two amino ... | ['Adaptor Proteins, Signal Transducing', 'Alternative Splicing', 'Amino Acid Sequence', 'Animals', 'Base Sequence', 'Brain', 'Chromosomes, Human, Pair 10', 'Cloning, Molecular', 'Codon, Initiator', 'Conserved Sequence', 'DNA-Binding Proteins', 'Exons', 'Gene Expression Profiling', 'Genetic Markers', 'Humans', 'Hybrid C... | 10,640,831 | [['D12.644.360.024', 'D12.776.157.057', 'D12.776.476.024'], ['G02.111.760.700.100', 'G03.839.700.100', 'G05.308.700.700.100'], ['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A08.186.211'], ['A11.284.187.520.300.325.350', 'G05.360.162.520.300.325.350... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Evaluation of three composting systems for the management of spent coffee grounds. | This study was conducted to evaluate the optimum composting approach for the management of spent coffee grounds from the restaurant and ready-to-serve coffee industry. Three composting systems were assessed, including in-vessel composting, vermicomposting bins, and aerated static pile bin composting, over study periods... | ['Animals', 'Carbon', 'Coffee', 'Electric Conductivity', 'Hydrogen-Ion Concentration', 'Nitrogen', 'Oligochaeta', 'Soil', 'Temperature'] | 21,704,514 | [['B01.050'], ['D01.268.150'], ['D20.215.784.249', 'G07.203.100.325', 'J02.200.325'], ['G01.358.500.249.277'], ['G02.300'], ['D01.268.604', 'D01.362.625'], ['B01.050.500.091.657'], ['D20.721', 'G01.311.820', 'G16.500.275.815', 'N06.230.600'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.15... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Three new species of the Neotropical genus Phyllotingis (Hemiptera: Heteroptera: Aradidae). | Three new species of Phyllotingis Walker, 1873 (Hemiptera: Heteroptera: Aradidae), Ph. tortugueria sp. nov. and Ph. costaricana sp. nov.from Costa Rica (representing a new generic record for the country), and Ph. moraguesi sp.nov. from French Guyana are described and illustrated. A key to all species of Phyllotingis is... | ['Animals', 'Costa Rica', 'Heteroptera'] | 30,313,467 | [['B01.050'], ['Z01.107.169.238'], ['B01.050.500.131.617.412.420']] | ['Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
A novel capsid expression strategy for Thosea asigna virus (Tetraviridae). | This paper presents evidence that Thosea asigna virus (TaV) has a unique capsid expression strategy and is a member of the Nudaurelia beta-like genus of the Tetraviridae. Electron microscopy of TaV particles indicated a 38 nm, T = 4 icosahedral capsid similar in structure to that of Nudaurelia beta virus (NbetaV). TaV ... | ['Amino Acid Sequence', 'Animals', 'Base Sequence', 'Capsid', 'Genome, Viral', 'Insect Viruses', 'Lepidoptera', 'Microscopy, Electron', 'Molecular Sequence Data', 'RNA, Viral', 'Sequence Alignment'] | 10,423,156 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A21.249.500.250'], ['G05.360.340.358.840'], ['B04.525'], ['B01.050.500.131.617.720.500.500.937'], ['E01.370.350.515.402', 'E05.595.402'], ['L01.453.245.667'], ['D13.444.735.828'], ['E05.393.751']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Patients with overactive bladders deserve better. | Tolterodine is an effective agent used to treat symptoms of overactive bladder. It is well tolerated and its selectivity for the bladder results in less side effects overall compared to many other agents. Many patients in New Zealand with symptoms of overactive bladder do not have access to tolterodine due to restricti... | ['Benzhydryl Compounds', 'Cost-Benefit Analysis', 'Cresols', 'Drug Administration Schedule', 'Drug Evaluation', 'Government Regulation', 'Humans', 'Muscarinic Antagonists', 'New Zealand', 'Phenylpropanolamine', 'Tolterodine Tartrate', 'Treatment Outcome', 'Urinary Incontinence'] | 16,498,474 | [['D02.455.426.559.389.115'], ['N03.219.151.125'], ['D02.455.426.559.389.657.239'], ['E02.319.283'], ['E05.290.625', 'E05.337.425'], ['I01.880.604.394', 'N03.706.358'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.519.625.120.200.500', 'D27.505.696.577.120.200.500'], ['Z01.639.760.747', 'Z01.678.100.747']... | ['Chemicals and Drugs [D]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Geographicals [Z]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Use of heterogeneous operation-specific contact parameters changes predictions for foot-and-mouth disease outbreaks in complex simulation models. | The role of contact parameters in a complex spatial simulation model of foot-and-mouth disease spread was determined by comparing predictions of number of infected premises, epidemic duration, and relative infection risk for different production sectors between a model that included the Full, heterogeneous (differing b... | ['Animals', 'Cattle', 'Cattle Diseases', 'Computers', 'Disease Outbreaks', 'Foot-and-Mouth Disease', 'Models, Biological', 'Stochastic Processes'] | 18,579,239 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['C22.196'], ['L01.224.230.260'], ['N06.850.290'], ['C01.925.782.687.484', 'C22.380'], ['E05.599.395'], ['E05.318.740.996', 'G17.830', 'N05.715.360.750.770', 'N06.850.520.830.996']] | ['Organisms [B]', 'Diseases [C]', 'Information Science [L]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Sphingosine inhibition and promotion of histamine release from isolated rat mast cells. | Sphingosine inhibited the histamine release induced by antigen, compound 48/80 with and without calcium, and the combination of TPA and the ionophore A23187. The inhibition occurred in the concentration range 1-3 microM, where no sign of cytotoxicity was noted. Preincubation for 5-10 min was needed for inhibition, and ... | ['Animals', 'Calcimycin', 'Calcium', 'Drug Interactions', 'Histamine Release', 'Male', 'Mast Cells', 'Rats', 'Rats, Inbred Strains', 'Sphingosine', 'Tetradecanoylphorbol Acetate', 'p-Methoxy-N-methylphenethylamine'] | 1,707,581 | [['B01.050'], ['D03.633.100.221.173'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['G07.690.773.968'], ['G12.350'], ['A11.329.427', 'A15.382.652'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760', 'B01.050.150.900.649.313.992.635.505.700.400'], ['D02.033.100.700', 'D02.033.455.843', ... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Stromal expression of MMP-9 and urokinase receptor is inversely associated with liver metastasis and with infiltrating growth in human colorectal cancer: a novel approach from immune/inflammatory aspect. | MMP-9 (gelatinase B) and urokinase-type plasminogen activator receptor (u-PAR), which are involved in cancer cell invasion and metastasis, are reported to be predominantly expressed by immune/inflammatory cells in human colorectal cancers. To investigate their significance in cancer progression, we morphometrically ana... | ['Antigens, CD', 'Antigens, Differentiation, Myelomonocytic', 'Collagenases', 'Colorectal Neoplasms', 'Gelatinases', 'Humans', 'Immunohistochemistry', 'Liver Neoplasms', 'Matrix Metalloproteinase 2', 'Matrix Metalloproteinase 8', 'Matrix Metalloproteinase 9', 'Metalloendopeptidases', 'Receptors, Cell Surface', 'Recepto... | 9,045,899 | [['D23.050.301.264.035', 'D23.101.100.110'], ['D23.050.301.264.900', 'D23.101.100.900'], ['D08.811.277.656.300.480.205', 'D08.811.277.656.675.374.205'], ['C04.588.274.476.411.307', 'C06.301.371.411.307', 'C06.405.249.411.307', 'C06.405.469.158.356', 'C06.405.469.491.307', 'C06.405.469.860.180'], ['D08.811.277.656.300.4... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
The NMR structure of the RNA binding domain of E. coli rho factor suggests possible RNA-protein interactions. | Rho protein is an essential hexameric RNA-DNA helicase that binds nascent mRNA transcripts and terminates transcription in a wide variety of eubacterial species. The NMR solution structure of the RNA binding domain of rho, rho130, is presented. This structure consists of two sub-domains, an N-terminal three-helix bundl... | ['Binding Sites', 'Crystallography, X-Ray', 'Escherichia coli', 'Models, Molecular', 'Nuclear Magnetic Resonance, Biomolecular', 'Protein Structure, Tertiary', 'RNA, Bacterial', 'RNA-Binding Proteins', 'Rho Factor'] | 9,587,002 | [['G02.111.570.120'], ['E05.196.309.742.225'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['E05.599.595'], ['E05.196.867.519.550'], ['G02.111.570.820.709.610'], ['D13.444.735.473'], ['D12.776.157.725', 'D12.776.664.962'], ['D12.776.930.785']] | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Stable messenger ribonucleic acid and germination of Myxococcus xanthus microcysts. | We have examined germination, protein synthesis and ribonucleic acid (RNA) synthesis by microcysts of the fruiting myxobacterium Myxococcus xanthus. The morphological aspects of microcyst formation were completed at about 2 hr after induction had begun. In such microcysts, germination, RNA synthesis, and protein synthe... | ['Bacteria', 'Bacterial Proteins', 'Carbon Isotopes', 'Centrifugation, Density Gradient', 'Culture Media', 'DNA, Bacterial', 'Dactinomycin', 'Electrophoresis', 'Leucine', 'RNA, Messenger', 'Time Factors', 'Tritium', 'Ultraviolet Rays', 'Uridine'] | 5,413,824 | [['B03'], ['D12.776.097'], ['D01.268.150.075', 'D01.496.123'], ['E05.181.724.336', 'E05.196.941.336'], ['D27.720.470.305', 'E07.206'], ['D13.444.308.212'], ['D03.633.300.200', 'D04.345.566.252', 'D12.644.641.252'], ['E05.196.401', 'E05.301.300'], ['D12.125.070.637', 'D12.125.142.441'], ['D13.444.735.544'], ['G01.910.85... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Climate change, urbanization and disease: summer in the city…. | Climate change and urbanization can alter the burden of human diseases. The tropics, a region that includes the poorest populations and highest disease burdens, are expected to get slightly hotter and substantially more urban. Studies have projected changing burdens under different climate or urbanization scenarios, bu... | ['Cities', 'Climate Change', 'Communicable Diseases', 'Humans', 'Rural Population', 'Seasons', 'Suburban Population', 'Tropical Climate', 'Urban Health', 'Urbanization'] | 25,491,136 | [['G16.500.275.069', 'N06.230.069', 'Z01.433'], ['G16.500.175.374'], ['C01.221', 'C23.550.291.531'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N01.600.725'], ['G01.910.645.661', 'G16.500.275.071.590', 'N06.230.300.100.250.525'], ['N01.600.775'], ['G16.500.275.071.600', 'N06.230.300.100.250.600'], ['N01.400.548... | ['Phenomena and Processes [G]', 'Health Care [N]', 'Geographicals [Z]', 'Diseases [C]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Anisakid larva from the throat of an Alaskan Eskimo. | An anisakid nematode, identified as Phocanema sp. fourth-stage larva, was "pulled" from the throat of a 46-year-old Alaskan Eskimo. The nematode is described and illustrated. | ['Alaska', 'Animals', 'Humans', 'Inuits', 'Larva', 'Nematoda', 'Nematode Infections', 'Pharynx'] | 961,991 | [['Z01.107.567.875.580.100'], ['B01.050'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.686.508.150.600.375.500', 'M01.686.508.150.675', 'M01.686.754.254.500.500'], ['B05.500.500', 'G07.345.500.550.500.500'], ['B01.050.500.500.294'], ['C01.610.335.508'], ['A03.556.750', 'A04.623', 'A14.724']] | ['Geographicals [Z]', 'Organisms [B]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
A histological evaluation of a functional endosseous, porous-surfaced, titanium alloy dental implant system in the dog. | We have previously reported the clinical and radiographic findings of a trial in dogs of a new dental implant system after a functional period of eight months. The present report consists of the corresponding qualitative and quantitative histological data. The implant system was fabricated from Ti-6A1-4V and employed a... | ['Alveolar Process', 'Animals', 'Bacterial Infections', 'Bone Regeneration', 'Dental Alloys', 'Dental Implantation, Endosseous', 'Dogs', 'Mandible', 'Prosthesis Failure', 'Titanium'] | 3,166,000 | [['A02.835.232.781.324.502.125', 'A14.521.125', 'A14.549.167.646.094'], ['B01.050'], ['C01.150.252'], ['G11.427.213.140', 'G16.762.150.150'], ['D25.339.208', 'J01.637.051.339.208'], ['E04.545.550.280.280', 'E04.650.230.500', 'E06.645.550.280.280', 'E06.780.314.310'], ['B01.050.150.900.649.313.750.250.216.200'], ['A02.8... | ['Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
[Frequency of attending primary care clinics by the immigrant versus autochthonous population]. | OBJECTIVES: To study the frequency of attendance in primary care of immigrant population compared to autochthonous one. To analyse differences in health services use according to geographical origin.METHODS: A retrospective descriptive study was carried out. All Family Medicine and Paediatrics consultations were analys... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Child', 'Child, Preschool', 'Emigrants and Immigrants', 'Female', 'Humans', 'Infant', 'Male', 'Middle Aged', 'Primary Health Care', 'Retrospective Studies', 'Spain', 'Young Adult'] | 21,536,353 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['M01.060.406'], ['M01.060.406.448'], ['M01.189'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.116.630'], ['N04.590.233.727'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.... | ['Named Groups [M]', 'Organisms [B]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
cDNA cloning of a third human C2-domain-containing class II phosphoinositide 3-kinase, PI3K-C2gamma, and chromosomal assignment of this gene (PIK3C2G) to 12p12. | Phosphoinositide (PI) 3-kinases have been shown to have critical roles in signaling pathways that regulate proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. We have previously used reverse-transcription polymerase chain reaction methods to identify novel PI 3... | ['Amino Acid Sequence', 'Binding Sites', 'Chromosome Mapping', 'Chromosomes, Human, Pair 12', 'Cloning, Molecular', 'Gene Expression', 'Humans', 'In Situ Hybridization, Fluorescence', 'Molecular Sequence Data', 'Phosphatidylinositol 3-Kinases', 'Sequence Homology, Amino Acid', 'Tissue Distribution'] | 9,878,262 | [['G02.111.570.060', 'L01.453.245.667.060'], ['G02.111.570.120'], ['E05.393.183'], ['A11.284.187.520.300.325.360', 'G05.360.162.520.300.325.360'], ['E05.393.220'], ['G05.297'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.620.670.325.350', 'E01.370.225.750.600.670.325.350', 'E05.200.500.620.670.32... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Computer-assisted analysis of human G-banded chromosomes. | The problem of data input into the computer was solved by means of an electromechanical scanner of our own design, which processes information from a positive photocopy. Classification of chromosomes in homologous pairs uses linear functions of discriminant variables. Evaluation of the quality of discriminant variables... | ['Chromosome Aberrations', 'Chromosome Banding', 'Chromosomes, Human', 'Computers', 'Female', 'Humans', 'Male', 'Minicomputers'] | 6,839,727 | [['C23.550.210', 'G05.365.590.175'], ['E01.370.225.500.385.130', 'E01.370.225.500.620.670.130', 'E01.370.225.750.600.670.130', 'E05.200.500.385.130', 'E05.200.500.620.670.130', 'E05.200.750.600.670.130', 'E05.242.385.130', 'E05.393.285.130'], ['A11.284.187.520.300', 'G05.360.162.520.300'], ['L01.224.230.260'], ['B01.05... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Information Science [L]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Prediction of functional outcome after stroke: comparison of the Orpington Prognostic Scale and the NIH Stroke Scale. | BACKGROUND AND PURPOSE: This study compared the ability of 2 stroke impairment scales, Orpington Prognostic Scale and National Institutes of Health (NIH) Stroke Scale, to predict disability as measured by the Barthel activities of daily living (ADL) Index and higher level of self-reported physical functioning as measur... | ['Activities of Daily Living', 'Aged', 'Cerebrovascular Disorders', 'Disability Evaluation', 'Female', 'Humans', 'Linear Models', 'Male', 'Middle Aged', 'Predictive Value of Tests', 'Prognosis', 'Treatment Outcome'] | 9,731,605 | [['E02.760.169.063.500.067', 'E02.831.067', 'I03.050', 'N02.421.784.110'], ['M01.060.116.100'], ['C10.228.140.300', 'C14.907.253'], ['E01.370.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.500', 'E05.318.740.750.425', 'E05.599.835.750', 'N05.715.360.750.530.460', 'N05.715.360.750.695.460', 'N... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Named Groups [M]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Congenital nasal cerebrospinal fluid fistula. | A management protocol for congenital nasal cerebrospinal fluid fistulas is proposed based on our successful experience with a twice recurrent fistula: 1. Careful preoperative observation of the skin dimple for fluid leakage. 2. Transnasal radiographic contrast study. 3. Synchronous transnasal-transcranial excision of t... | ['Abnormalities, Multiple', 'Cerebrospinal Fluid Rhinorrhea', 'Child, Preschool', 'Humans', 'Male', 'Meningocele', 'Methods'] | 7,079,407 | [['C16.131.077'], ['C10.597.114.750', 'C10.900.300.109.750', 'C23.888.592.114.624', 'C23.888.852.834.500', 'C26.915.300.225.750'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.500.680.598', 'C16.131.666.680.598', 'C23.300.707.968'], ['E05.581']] | ['Diseases [C]', 'Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Rapamycin-mediated interaction of spleen ãäT lymphocytes and lung macrophages in acute lung injury of mice induced by lipopolysaccharide]. | OBJECTIVE: To explore the influences of rapamycin (RAPA) upon the cytokine changes of activated spleen ãäT lymphocytes and lung tissue macrophages in acute lung injury of mice induced by lipopolysaccharide (LPS).METHODS: A total of 24 healthy male C57BL/6 mice, 6-8 weeks old, were randomly divided into phosphate buffer... | ['Acute Lung Injury', 'Animals', 'Cell Communication', 'Coculture Techniques', 'Interferon-gamma', 'Lipopolysaccharides', 'Macrophages, Alveolar', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Sirolimus', 'Spleen', 'T-Lymphocytes', 'Tumor Necrosis Factor-alpha'] | 21,600,178 | [['C08.381.520.500'], ['B01.050'], ['G04.085'], ['E05.481.500.374'], ['D12.644.276.374.440.893', 'D12.644.276.374.480.615.350', 'D12.776.467.374.440.893', 'D12.776.467.374.480.615.350', 'D23.529.374.440.893', 'D23.529.374.480.615.350'], ['D09.400.500', 'D09.698.718.450', 'D10.494', 'D23.050.161.616.525', 'D23.946.123.3... | ['Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Factors and motives associated with drop-out in an ambulatory service for patients with psychotic disorders. | The aim is to study motives and factors associated with treatment drop-out in an ambulatory psychiatric service, which integrates medical, social, familial and rehabilitation treatments. Only 9% of the psychotic patients dropped out, whose motives were non-compliance with medication and unawareness of illness, and the ... | ['Adult', 'Ambulatory Care', 'Antipsychotic Agents', 'Comorbidity', 'Female', 'Humans', 'Male', 'Motivation', 'Patient Dropouts', 'Psychotic Disorders', 'Retrospective Studies', 'Sick Role', 'Social Isolation', 'Substance-Related Disorders', 'Treatment Refusal'] | 12,814,855 | [['M01.060.116'], ['E02.760.106', 'N02.421.585.106'], ['D27.505.696.277.950.040', 'D27.505.954.427.210.950.040', 'D27.505.954.427.700.872.331'], ['N05.715.350.225', 'N06.850.490.687'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.658', 'F01.752.543.500.750'], ['F01.100.150.750.500.610', 'F01.145.488.887.500.6... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Haemodynamic dose-response effects of intravenous labetalol in acute myocardial infarction. | The haemodynamic consequences of combined alpha- and beta-adrenoceptor blockade with intravenous labetalol were evaluated in 21 males with either high (n = 6), normal (n = 9) or low (n = 6) systemic arterial pressure, 4-17 hours after acute myocardial infarction without heart failure. Labetalol 190 +/- 18 mg (range 62-... | ['Dose-Response Relationship, Drug', 'Drug Administration Schedule', 'Ethanolamines', 'Hemodynamics', 'Humans', 'Infusions, Parenteral', 'Labetalol', 'Male', 'Middle Aged', 'Myocardial Infarction'] | 6,647,215 | [['G07.690.773.875', 'G07.690.936.500'], ['E02.319.283'], ['D02.033.100.291', 'D02.033.375.291', 'D02.092.063.291'], ['G09.330.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.267.510'], ['D02.033.100.291.460', 'D02.065.793.324', 'D02.092.063.291.460'], ['M01.060.116.630'], ['C14.280.647.500', 'C14.907... | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Named Groups [M]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
CADRE: the Central Aspergillus Data REpository 2012. | The Central Aspergillus Data REpository (CADRE; http://www.cadre-genomes.org.uk) is a public resource for genomic data extracted from species of Aspergillus. It provides an array of online tools for searching and visualising features of this significant fungal genus. CADRE arose from a need within the medical community... | ['Aspergillus', 'Databases, Genetic', 'Genome, Fungal', 'Genomics', 'Software'] | 22,080,563 | [['B01.300.381.081'], ['L01.313.500.750.300.188.400.325', 'L01.470.750.750.325'], ['G05.360.340.358.365'], ['H01.158.273.180.350', 'H01.158.273.343.350'], ['L01.224.900']] | ['Organisms [B]', 'Information Science [L]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Study of Akabane infection in Saudi Arabia by the use of sentinel ruminants. | Two sentinel herds of calves (Eastern and Central regions of Saudi Arabia) and one of sheep and goats (South Western region) were established to study Akabane virus infection. The herd at the Al-Ahsa oasis (Eastern region) showed evidence of Akabane viral activity, as reflected by the presence of maternal (colostral) a... | ['Animals', 'Antibodies, Viral', 'Bunyaviridae Infections', 'Cattle', 'Cattle Diseases', 'Cell Line', 'Chlorocebus aethiops', 'Cricetinae', 'Goat Diseases', 'Goats', 'Saudi Arabia', 'Sentinel Surveillance', 'Serologic Tests', 'Sheep', 'Sheep Diseases', 'Simbu virus', 'Vero Cells', 'Viral Plaque Assay'] | 9,839,208 | [['B01.050'], ['D12.776.124.486.485.114.254', 'D12.776.124.790.651.114.254', 'D12.776.377.715.548.114.254'], ['C01.925.782.147'], ['B01.050.150.900.649.313.500.380.271'], ['C22.196'], ['A11.251.210'], ['B01.050.150.900.649.313.988.400.112.199.120.126.110'], ['B01.050.150.900.649.313.992.635.075.250'], ['C22.405'], ['B0... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Serotype-Independent Protection Against Invasive Pneumococcal Infections Conferred by Live Vaccine With lgt | Streptococcus pneumoniae is the most common respiratory bacterial pathogen among cases of community-acquired infection in young children, older adults, and individuals with underlying medical conditions. Although capsular polysaccharide-based pneumococcal vaccines have contributed to significant decrease in invasive pn... | ['Administration, Intranasal', 'Animals', 'Antibodies, Bacterial', 'Bacterial Capsules', 'Bacterial Proteins', 'Genes, Bacterial', 'Immunity, Mucosal', 'Immunogenicity, Vaccine', 'Immunoglobulin Isotypes', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Nasopharynx', 'Pneumococcal Infections', 'Pneumococcal Vaccines', 'RAW 264.... | 31,191,555 | [['E02.319.267.120.655.500'], ['B01.050'], ['D12.776.124.486.485.114.107', 'D12.776.124.790.651.114.125', 'D12.776.377.715.548.114.125'], ['A20.186'], ['D12.776.097'], ['G05.360.340.024.340.364.249', 'G05.360.340.358.024.249', 'G05.360.340.358.207.249'], ['G12.450.573'], ['G12.513'], ['D12.776.124.486.485.114.619', 'D1... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Laser-induced changes of in vitro erythrocyte sedimentation rate. | The study of the effects of low-level laser (LLL) radiation on blood is important for elucidating the mechanisms behind the interaction of LLL radiation and biologic tissues. Different therapy methods that involve blood irradiation have been developed and used for clinical purposes with beneficial effects. The aim of t... | ['Adult', 'Blood Sedimentation', 'Cell Shape', 'Dose-Response Relationship, Radiation', 'Erythrocyte Count', 'Erythrocyte Volume', 'Erythrocytes', 'Hematocrit', 'Humans', 'Lasers, Solid-State', 'Plasma'] | 28,967,036 | [['M01.060.116'], ['E01.370.225.625.125', 'E05.200.625.125'], ['G04.320'], ['E05.799.513.500', 'G01.750.740.500', 'G04.712.500', 'G07.225', 'G07.738.500', 'N06.850.810.250.180'], ['E01.370.225.500.195.107.330', 'E01.370.225.625.107.330', 'E05.200.500.195.107.330', 'E05.200.625.107.330', 'E05.242.195.107.330', 'G04.140.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Study on kidney function in female workers exposed to perchlorethylene. | 1. Biochemical markers of kidney damage were examined in 16 female workers chronically exposed to tetrachlorethylene (TCE) in five dry-cleaning shops. The results were compared with those obtained in 13 females non-occupationally exposed to organic solvents. 2. The intensity of exposure was monitored by personal enviro... | ['Environmental Monitoring', 'Female', 'Humans', 'Kidney', 'Muramidase', 'Occupational Exposure', 'Tetrachloroethylene', 'Time Factors'] | 2,271,228 | [['N06.850.460.350.080', 'N06.850.780.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A05.810.453'], ['D08.811.277.450.642'], ['N06.850.460.350.600'], ['D02.455.526.439.880'], ['G01.910.857']] | ['Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
In vitro | In vitro activity against methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus epidermidis biofilm producers from blood cultures of patients with prosthetic hip infections was evaluated. The Minimum Inhibitory Concentration (MIC) for AP7121 was determined and the bactericidal activity of AP7121 (MICx1,... | ['Anti-Bacterial Agents', 'Bacterial Adhesion', 'Biofilms', 'Hip Prosthesis', 'Humans', 'In Vitro Techniques', 'Methicillin-Resistant Staphylococcus aureus', 'Microbial Sensitivity Tests', 'Microscopy, Electron, Scanning', 'Plankton', 'Staphylococcal Infections', 'Staphylococcus aureus', 'Staphylococcus epidermidis'] | 32,338,055 | [['D27.505.954.122.085'], ['G06.099.050'], ['A20.593', 'G06.120'], ['E07.695.400.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.481'], ['B03.300.390.400.800.750.100.500', 'B03.353.500.750.750.100.500', 'B03.510.100.750.750.100.500', 'B03.510.400.790.750.100.500'], ['E01.370.225.875.595', 'E05.200.875.595... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Conservation of the blood]. | Many factors already contribute to limit the amount of bank blood available for therapeutic use; a possible reduction in the amount of available blood could stem from the relative indifference of young people towards the gift of blood and the increase in the size of the pool of positive carriers of Australian antigen. ... | ['Attitude of Health Personnel', 'Blood', 'Blood Banks', 'Blood Transfusion', 'Blood Transfusion, Autologous', 'Education, Medical', 'Halothane', 'Humans', 'Hypotension, Controlled', 'Nitroprusside', 'Plasma Substitutes', 'Surgical Procedures, Operative', 'Trimethaphan'] | 1,139,383 | [['F01.100.050', 'N05.300.100'], ['A12.207.152', 'A15.145'], ['N02.278.065.200'], ['E02.095.135'], ['E02.095.135.164'], ['I02.358.399'], ['D02.455.526.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E03.545'], ['D01.248.497.158.291.350.550', 'D01.490.100.300.550', 'D01.625.400.100.325.550'], ['D27.505.954.502... | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
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