Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Cellular transformation by subgenomic feline sarcoma virus DNA. | The genome of the Snyder-Theilen strain of feline sarcoma virus (ST-FeSV) is a 4.3-kilobase-pair (kbp) RNA molecule that contains a 1.5-kbp cellular insertion (fes gene) flanked by feline leukemia virus sequences at its 5' end (1.6 kbp) and 3' end (1.2 kbp) (Sherr et al., J. Virol. 34:200-212, 1980). DNA transfection t... | ['Animals', 'Cell Line', 'Cell Transformation, Viral', 'Chromosome Mapping', 'Clone Cells', 'DNA, Viral', 'Genes, Viral', 'Mice', 'Mink', 'Repetitive Sequences, Nucleic Acid', 'Retroviridae', 'Sarcoma Viruses, Feline', 'Transformation, Genetic'] | 6,261,000 | [['B01.050'], ['A11.251.210'], ['C04.697.098.500.160', 'C23.550.727.098.500.160', 'G06.920.143'], ['E05.393.183'], ['A11.251.353'], ['D13.444.308.568'], ['G05.360.340.024.340.364.875', 'G05.360.340.358.024.875', 'G05.360.340.358.840.500'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.150.900.649.313.750.250.5... | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Simultaneous analysis of the behavioural phenotype, physical factors, and parenting stress in people with Cornelia de Lange syndrome. | BACKGROUND: Studies into the phenotype of rare genetic syndromes largely rely on bivariate analysis. The aim of this study was to describe the phenotype of Cornelia de Lange syndrome (CdLS) in depth by examining a large number of variables with varying measurement levels. Virtually the only suitable multivariate techni... | ['Activities of Daily Living', 'Adolescent', 'Adult', 'Autistic Disorder', 'Caregivers', 'Cell Cycle Proteins', 'Child', 'Child, Preschool', 'Chondroitin Sulfate Proteoglycans', 'Chromosomal Proteins, Non-Histone', 'Comorbidity', 'Cost of Illness', 'DNA Mutational Analysis', 'De Lange Syndrome', 'Disability Evaluation'... | 19,522,789 | [['E02.760.169.063.500.067', 'E02.831.067', 'I03.050', 'N02.421.784.110'], ['M01.060.057'], ['M01.060.116'], ['F03.625.164.113.500'], ['M01.085', 'M01.526.485.200', 'N02.360.200'], ['D12.776.167'], ['M01.060.406'], ['M01.060.406.448'], ['D09.698.735.200', 'D12.776.395.650.750'], ['D12.776.660.235', 'D12.776.664.235'], ... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Cerebral histoplasmoma. Case report. | A 55-year-old man presented with dementia and seizures of recent onset. A computerized tomography scan revealed a ring-like lesion in the left occipital lobe, which on resection was found to be a histoplasmoma. Cerebral histoplasmoma is rare and simulates a metastatic brain tumor. Only eight cases of this entity have b... | ['Brain Diseases', 'Granuloma', 'Histoplasmosis', 'Humans', 'Male', 'Middle Aged'] | 6,864,301 | [['C10.228.140'], ['C15.604.515.292', 'C23.550.382'], ['C01.150.703.450'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630']] | ['Diseases [C]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Prolonged hypoxia augments L-citrulline transport by system A in the newborn piglet pulmonary circulation. | AIMS: Pulmonary arterial endothelial cells (PAECs) express the enzymes needed for generation of l-arginine from intracellular l-citrulline but do not express the enzymes needed for de novo l-citrulline synthesis. Hence, l-citrulline levels in PAECs are dependent on l-citrulline transport. Once generated, l-arginine can... | ['Amino Acid Transport System A', 'Animals', 'Animals, Newborn', 'Biological Transport', 'Cells, Cultured', 'Chronic Disease', 'Citrulline', 'Disease Models, Animal', 'Endothelial Cells', 'Familial Primary Pulmonary Hypertension', 'Hypertension, Pulmonary', 'Hypoxia', 'Membrane Transport Modulators', 'Nitric Oxide', 'P... | 22,673,370 | [['D12.776.157.530.200.500.100', 'D12.776.543.585.200.500.100'], ['B01.050'], ['B01.050.050.282'], ['G03.143'], ['A11.251'], ['C23.550.291.500'], ['D12.125.095.226'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['A11.436.275'], ['C08.381.423.300'], ['C08.381.423', 'C14.907.489.556'], ['C23.888.852.079'], ['D27.505.5... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Biomarkers of oxidative damage in cigarette smokers: which biomarkers might reflect acute versus chronic oxidative stress? | Cigarette smoking predisposes to the development of multiple diseases involving oxidative damage. We measured a range of oxidative damage biomarkers to understand which differ between smokers and nonsmokers and if the levels of these biomarkers change further during the act of smoking itself. Despite overnight abstinen... | ["8-Hydroxy-2'-Deoxyguanosine", 'Adult', 'Aged', 'Allantoin', 'Biomarkers', 'Deoxyguanosine', 'F2-Isoprostanes', 'Free Radicals', 'Humans', 'Hydroxycholesterols', 'Hydroxyeicosatetraenoic Acids', 'Ketocholesterols', 'Male', 'Middle Aged', 'Oxidative Stress', 'Smoking'] | 21,420,490 | [['D03.633.100.759.590.454.240.500', 'D13.570.230.360.500', 'D13.570.583.454.240.500'], ['M01.060.116'], ['M01.060.116.100'], ['D02.065.950.058', 'D03.383.129.308.432.555.105'], ['D23.101'], ['D03.633.100.759.590.454.240', 'D13.570.230.360', 'D13.570.583.454.240'], ['D10.251.355.255.100.375.500', 'D10.251.355.310.166.7... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Revision of opeatocerata melander, 1928 (Diptera: empididae: empidinae). | The species of the Neotropical genus Opeatocerata Melander are revised to include 21 species, with fifteen species described as new: O. agudeloi sp. nov., O. ampullaria sp. nov., O. bare sp. nov., O. brasiliensis sp. nov., O. chaetohypandrialis sp. nov., O. cylindrophallus sp. nov., O. curvipenis sp. nov., O. hadrophal... | ['Animals', 'Diptera', 'Female', 'Male', 'South America'] | 25,112,264 | [['B01.050'], ['B01.050.500.131.617.720.500.500.750'], ['Z01.107.757']] | ['Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
[The laparoscopic picture of endometriosis in women with sterility]. | It is the purpose of this study to document the variegated appearance of endometriosis at laparoscopy, and select suitable cases indicated for microsurgery. Three-hundred and four patients undergo diagnostic laparoscopy between January 1991 and June 1992. Endometriosis diagnosed during laparoscopy is staged according t... | ['Endometriosis', 'Female', 'Humans', 'Infertility, Female', 'Laparoscopy', 'Tissue Adhesions'] | 8,531,444 | [['C13.351.500.163'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C13.351.500.365.700'], ['E01.370.388.250.520', 'E04.502.250.520'], ['C23.550.355.274.840']] | ['Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Estimation of the time-varying reproduction number of COVID-19 outbreak in China. | BACKGROUND: The 2019 novel coronavirus (COVID-19) outbreak in Wuhan, China has attracted world-wide attention. As of March 31, 2020, a total of 82,631 cases of COVID-19 in China were confirmed by the National Health Commission (NHC) of China.METHODS: Three approaches, namely Poisson likelihood-based method (ML), expone... | ['Basic Reproduction Number', 'Betacoronavirus', 'COVID-19', 'China', 'Coronavirus Infections', 'Disease Outbreaks', 'Humans', 'Models, Statistical', 'Pandemics', 'Pneumonia, Viral', 'SARS-CoV-2'] | 32,460,229 | [['E05.318.308.985.525.080', 'N01.224.935.597.080', 'N06.850.335.125', 'N06.850.505.400.975.525.080', 'N06.850.520.308.985.525.080'], ['B04.820.578.500.540.150.113'], ['C01.748.214', 'C01.748.610.763.500', 'C01.925.705.500', 'C01.925.782.600.550.200.163', 'C08.381.677.807.500', 'C08.730.214', 'C08.730.610.763.500'], ['... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Traumatic Retroclival Epidural Hematoma. | Retroclival epidural hematomas are particularly rare conditions that are frequently the result of high-energy, hyperflexion-hyperextension injuries in pediatric patients. We present the case of a 7-year-old previously healthy girl with traumatic retroclival epidural hematoma after a fall from a swing. She presented wit... | ['Child', 'Conservative Treatment', 'Female', 'Glasgow Coma Scale', 'Hematoma, Epidural, Cranial', 'Humans', 'Intracranial Hemorrhage, Traumatic', 'Magnetic Resonance Imaging', 'Movement', 'Neck Pain', 'Radiography', 'Tomography, X-Ray Computed', 'Treatment Outcome'] | 31,593,055 | [['M01.060.406'], ['E02.197'], ['E05.318.308.940.968.875.250', 'E05.944.500', 'N04.452.859.564.800.250', 'N05.715.360.300.715.500.800.325'], ['C10.228.140.300.535.450.300', 'C10.900.300.837.300', 'C14.907.253.573.400.400', 'C23.550.414.838.349', 'C23.550.414.913.400', 'C26.915.300.490.400'], ['B01.050.150.900.649.313.9... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Altered expression of serum protein in ginsenoside Re-treated diabetic rats detected by SELDI-TOF MS. | Diabetes mellitus (DM) is now a global health problem, however, its pathogenesis has not yet been fully deciphered. Even though modern medicine has great contribution to the control and treatment of DM, it is still far from success to completely cure the disease. Panax ginseng C.A. Meyer (ginseng) is a well-recognized ... | ['Administration, Oral', 'Animals', 'Blood Proteins', 'C-Reactive Protein', 'Diabetes Mellitus, Experimental', 'Enzyme-Linked Immunosorbent Assay', 'Ginsenosides', 'Male', 'Medicine, Chinese Traditional', 'Proteome', 'Proteomics', 'Rats', 'Rats, Sprague-Dawley', 'Reproducibility of Results', 'Spectrometry, Mass, Matrix... | 16,797,897 | [['E02.319.267.100'], ['B01.050'], ['D12.776.124'], ['D12.776.034.145', 'D12.776.124.050.120', 'D12.776.124.486.157'], ['C18.452.394.750.074', 'C19.246.240', 'E05.598.500.374'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['D02.455.849.919.277', '... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 |
Activity pattern-dependent long-term potentiation in neocortex and hippocampus of GluA1 (GluR-A) subunit-deficient mice. | The AMPA receptor subunit GluA1 (GluR-A) has been implicated to be critically involved in the expression of long-term potentiation (LTP) and memory formation. Mice lacking this subunit possess a profound spatial working memory deficit. We investigated the influence of the GluA1 subunit on the expression of LTP in pyram... | ['Action Potentials', 'Animals', 'Hippocampus', 'Long-Term Potentiation', 'Mice', 'Mice, Knockout', 'Neocortex', 'Receptors, AMPA'] | 19,403,825 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['B01.050'], ['A08.186.211.180.405', 'A08.186.211.200.885.287.500.345'], ['G11.561.638.350'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.136.500.500', 'B01.050.150.900.649.313.992.635.505.500.550.455', 'B01.050.150.900.649.313.992.635.505.500.800.5... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Comparison of heparin-coated and conventional split-tip hemodialysis catheters. | Catheter coatings have the potential to decrease infection and thrombosis in patients with chronic dialysis catheters. We report our midterm experience with a heparin-coated dialysis catheter. This retrospective, case-control study was approved by our Institutional Review Board. A total of 88 tunneled dialysis catheter... | ['Case-Control Studies', 'Catheterization, Central Venous', 'Coated Materials, Biocompatible', 'Female', 'Heparin', 'Humans', 'Jugular Veins', 'Male', 'Radiography, Interventional', 'Renal Dialysis', 'Retrospective Studies', 'Treatment Outcome', 'Ultrasonography, Interventional', 'Vascular Patency'] | 19,488,816 | [['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['E02.148.167', 'E04.100.814.529.875', 'E04.502.382.875', 'E05.157.313'], ['D25.130.420', 'J01.637.051.130.420'], ['D09.698.373.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A07.015.908.498'], ['E01.370.350.700.725', 'E04.502.78... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Histopathological study of pulmonary arteries in 14 autopsy cases with massive pulmonary thromboembolism. | As the pathological features of acute massive pulmonary thromboembolism (PTE) remain unclear, early diagnosis is difficult. We examined 14 autopsy cases of sudden death by massive PTE. Eight cases were male and six female, with a mean age of 57+/-18 years. While none of the cases were diagnosed with PTE during their li... | ['Acute Disease', 'Autopsy', 'Death, Sudden', 'Female', 'Humans', 'Leg', 'Male', 'Middle Aged', 'Pulmonary Artery', 'Pulmonary Embolism', 'Recurrence', 'Venous Thrombosis'] | 12,935,620 | [['C23.550.291.125'], ['E01.370.060', 'E05.070', 'I01.198.780.937.120'], ['C23.550.260.322'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A01.378.610.500'], ['M01.060.116.630'], ['A07.015.114.715'], ['C08.381.746', 'C14.907.355.350.700'], ['C23.550.291.937'], ['C14.907.355.830.925']] | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Anatomy [A]', 'Named Groups [M]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Accuracy of using Diagnosis Procedure Combination administrative claims data for estimating the amount of opioid consumption among cancer patients in Japan. | OBJECTIVE: The state of opioid consumption among cancer patients has never been comprehensively investigated in Japan. The Diagnosis Procedure Combination claims data may be used to measure and monitor opioid consumption among cancer patients, but the accuracy of using the Diagnosis Procedure Combination data for this ... | ['Adult', 'Aged', 'Aged, 80 and over', 'Analgesics, Opioid', 'Codeine', 'Drug Prescriptions', 'Female', 'Fentanyl', 'Humans', 'Insurance Claim Review', 'Japan', 'Male', 'Middle Aged', 'Morphine', 'Neoplasms', 'Oxycodone', 'Pain', 'Tramadol'] | 26,358,712 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.696.277.600.500', 'D27.505.696.663.850.014.760.500', 'D27.505.954.427.040.550.500', 'D27.505.954.427.210.600.500'], ['D03.132.577.249.562.149', 'D03.605.497.607.204', 'D03.633.400.686.607.204', 'D04.615.723.795.576.149'], ['E02.319.307', 'N02.421... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Comparison of standard and accelerated initiation of renal replacement therapy in acute kidney injury. | In patients with severe acute kidney injury (AKI) but no urgent indication for renal replacement therapy (RRT), the optimal time to initiate RRT remains controversial. While starting RRT preemptively may have benefits, this may expose patients to unnecessary RRT. To study this, we conducted a 12-center open-label pilot... | ['Acute Kidney Injury', 'Aged', 'Canada', 'Critical Illness', 'Feasibility Studies', 'Female', 'Hospital Mortality', 'Humans', 'Kidney', 'Length of Stay', 'Male', 'Middle Aged', 'Pilot Projects', 'Renal Replacement Therapy', 'Risk Factors', 'Severity of Illness Index', 'Time Factors', 'Time-to-Treatment', 'Treatment Ou... | 26,154,928 | [['C12.777.419.780.050', 'C13.351.968.419.780.050'], ['M01.060.116.100'], ['Z01.107.567.176'], ['C23.550.291.625'], ['E05.318.372.550', 'E05.337.675', 'N05.715.360.330.550', 'N06.850.520.450.550'], ['E05.318.308.985.550.400', 'N01.224.935.698.400', 'N06.850.505.400.975.550.400', 'N06.850.520.308.985.550.400'], ['B01.05... | ['Diseases [C]', 'Named Groups [M]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Supplementation of zinc mitigates the altered uptake and turnover of 65Zn in liver and whole body of diabetic rats. | Diabetes is a life threatening disease and its onset is linked with both environmental and genetic factors. Zinc metabolism gets altered during diabetes and results in many complications. The present study was designed to elucidate the effects of zinc supplementation on the biokinetics of (65)Zn in whole body, liver an... | ['Animals', 'Diabetes Mellitus, Experimental', 'Dietary Supplements', 'Humans', 'Liver', 'Male', 'Rats', 'Rats, Wistar', 'Tissue Distribution', 'Zinc', 'Zinc Radioisotopes'] | 21,584,710 | [['B01.050'], ['C18.452.394.750.074', 'C19.246.240', 'E05.598.500.374'], ['G07.203.300.456', 'J02.500.456'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A03.620'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.900'], ['G03.787.917', 'G07.690.725.949'], ['D01.268.556.940',... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Comparison of three methods for detection of carious lesions in proximal surfaces versus direct visual examination after tooth separation. | The present study aimed to compare clinical, fiber-optic transillumination and bite-wing radiographic assessment of carious lesion depth in contacting proximal surfaces with the results obtained by direct visual inspection after tooth separation of the respective surfaces. It is suggested that when a carious lesion is ... | ['Adolescent', 'Dental Caries', 'Dental Caries Activity Tests', 'Humans', 'Radiography, Bitewing', 'Reproducibility of Results', 'Transillumination'] | 14,604,144 | [['M01.060.057'], ['C07.793.720.210'], ['E06.342.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.700.720.700', 'E06.342.764.600'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['E01.370.350.589.500', 'E05.642.500']] | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[The effect of additional albumin with optimal concentration on the reperfusion after preservation of isolated rat hearts]. | We studied the effect of additional albumin in preservation solution on reperfusion after immersion of isolated rat hearts by measuring cardiac function, myocardial enzymes and calcium. Male Wistar rats weighing 300 gr to 450 gr were used. Isolated rat hearts were arrested by cardioplegic solution and washed out with p... | ['Albumins', 'Animals', 'Calcium', 'Heart', 'Hypertonic Solutions', 'In Vitro Techniques', 'Male', 'Malondialdehyde', 'Myocardial Reperfusion', 'Myocardial Reperfusion Injury', 'Myocardium', 'Organ Preservation', 'Rats', 'Rats, Wistar'] | 8,377,753 | [['D12.776.034'], ['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['A07.541'], ['D26.776.314'], ['E05.481'], ['D02.047.700'], ['E04.100.700.600', 'E05.680.730.600'], ['C14.280.238.615', 'C14.280.647.625', 'C14.907.585.625', 'C14.907.725.600', 'C23.550.767.877.500'], ['A02.633.580', 'A07.541.704', 'A... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Temporal-spatial expressions of Spy1 in rat sciatic nerve after crush. | As a novel cell cycle protein, Spy1 enhances cell proliferation, promotes the G1/S transition as well as inhibits apoptosis in response to UV irradiation. Spy1 levels are tightly regulated during mammary development, and overexpression of Spy1 accelerates tumorigenesis in vivo. But little is known about the role of Spy... | ['Aging', 'Animals', 'Axons', 'Biomarkers', 'Cell Cycle Proteins', 'Cell Proliferation', 'Female', 'Fluorescent Antibody Technique', 'Gene Expression Regulation', 'Male', 'Nerve Crush', 'Nerve Regeneration', 'Phenotype', 'Protein Transport', 'RNA, Messenger', 'Rats', 'Rats, Sprague-Dawley', 'Schwann Cells', 'Sciatic Ne... | 23,129,232 | [['G07.345.124'], ['B01.050'], ['A08.675.542.145', 'A11.284.180.075', 'A11.671.137', 'A11.671.501.145'], ['D23.101'], ['D12.776.167'], ['G04.161.750', 'G07.345.249.410.750'], ['E01.370.225.500.607.512.240', 'E01.370.225.750.551.512.240', 'E05.200.500.607.512.240', 'E05.200.750.551.512.240', 'E05.478.583.375'], ['G05.30... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Identification of a novel mutation in a Korean patient with oculopharyngeal muscular dystrophy. | Oculopharyngeal muscular dystrophy (OPMD) is a late-onset muscle disorder characterized by progressive dysphagia and bilateral ptosis. Mutations in the polyadenylate binding protein nuclear 1 (PABPN1) gene have been found to cause OPMD. The typical mutation is a stable trinucleotide repeat expansion in the first exon o... | ['Blepharoptosis', 'DNA Transposable Elements', 'Deglutition Disorders', 'Exons', 'Humans', 'Korea', 'Male', 'Middle Aged', 'Muscular Dystrophy, Oculopharyngeal', 'Mutation', 'Pedigree', 'Poly(A)-Binding Protein II', 'Trinucleotide Repeats'] | 17,138,075 | [['C11.338.204'], ['D13.444.308.520', 'G02.111.570.080.708.330.200', 'G05.360.080.708.330.200', 'G05.360.340.024.425.200'], ['C06.405.117.119', 'C09.775.174'], ['G05.360.340.024.340.137.232'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.474.557', 'Z01.586.407'], ['M01.060.116.630'], ['C05.651.534.500.450... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Geographicals [Z]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
[Dosage reduction in computed tomography by anatomy-oriented attenuation-based tube-current modulation: the first clinical results]. | PURPOSE: To examine the feasibility of reducing exposition in CT examinations by applying a prototype device for tube current modulation with the image quality remaining unchanged.PATIENTS AND METHODS: The prototype device for tube current modulation was integrated into a Somatom Plus 4 CT scanner (Siemens). The method... | ['Artifacts', 'Feasibility Studies', 'Humans', 'Neoplasms', 'Observer Variation', 'Radiation Dosage', 'Shoulder', 'Tomography, X-Ray Computed'] | 10,230,432 | [['E05.047'], ['E05.318.372.550', 'E05.337.675', 'N05.715.360.330.550', 'N06.850.520.450.550'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04'], ['E01.354.753', 'N02.421.450.600', 'N05.715.350.150.675', 'N06.850.490.500.250'], ['E05.799.513', 'G01.750.740', 'N06.850.810.250'], ['A01.378.800.750'], ['E01.370.35... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Demethylation using the epigenetic modifier, 5-azacytidine, increases the efficiency of transient transfection of macrophages. | This study was aimed at developing a method for high-efficiency transient transfection of macrophages. Seven methods were evaluated for transient transfection of murine macrophage RAW 264.7 cells. The highest transfection efficiency was achieved with DEAE-dextran, although the proportion of cells expressing the reporte... | ['Adenoviridae', 'Animals', 'Azacitidine', 'Cell Line', 'Cholestanetriol 26-Monooxygenase', 'Cholesterol', 'Cytomegalovirus', 'DEAE-Dextran', 'DNA', 'DNA Methylation', 'Dose-Response Relationship, Drug', 'Enzyme Inhibitors', 'Genes, Reporter', 'Green Fluorescent Proteins', 'Humans', 'Lipids', 'Macrophages', 'Methylatio... | 15,520,456 | [['B04.280.030'], ['B01.050'], ['D02.145.150', 'D03.383.742.680.245.217', 'D13.570.685.245.217', 'D13.570.800.286.300'], ['A11.251.210'], ['D08.244.453.499.750', 'D08.244.453.915.149', 'D08.811.682.690.708.170.493.750', 'D08.811.682.690.708.170.915.150', 'D12.776.422.220.453.499.750', 'D12.776.422.220.453.915.150'], ['... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
MiR-25-3p attenuates the proliferation of tongue squamous cell carcinoma cell line Tca8113. | OBJECTIVE: To investigate the effects of miR-25-3p on the occurrence, development and proliferation of tongue squamous cell carcinoma cells.METHODS: To establish tongue squamous cell carcinoma cell line Tca8113 that stably and highly express miR-25-3p using recombinant retroviral vector-mediated gene transfer method. T... | ['Carcinoma, Squamous Cell', 'Cell Cycle Proteins', 'Cell Line, Tumor', 'Cell Proliferation', 'Down-Regulation', 'Gene Expression Regulation, Neoplastic', 'Humans', 'MicroRNAs', 'Tongue Neoplasms', 'Transfection'] | 23,827,155 | [['C04.557.470.200.400', 'C04.557.470.700.400'], ['D12.776.167'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.161.750', 'G07.345.249.410.750'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['G05.308.370'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D13.150.650.319', 'D13.444.735.150.319', 'D13.444.735.7... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Yanucamides A and B, two new depsipeptides from an assemblage of the marine cyanobacteria Lyngbya majuscula and Schizothrix species. | Yanucamides A (1) and B (2) were isolated from the lipid extract of a Lyngbya majuscula and Schizothrixsp. assemblage collected at Yanuca Island, Fiji. The structures of compounds 1 and 2 were determined by spectroscopic methods. Both compounds contain a unique 2,2-dimethyl-3-hydroxy-7-octynoic acid, which has previous... | ['Animals', 'Artemia', 'Chromatography, High Pressure Liquid', 'Cyanobacteria', 'Depsipeptides', 'Fiji', 'Lethal Dose 50', 'Magnetic Resonance Spectroscopy', 'Mollusca', 'Peptides, Cyclic', 'Spectrometry, Mass, Fast Atom Bombardment'] | 10,691,708 | [['B01.050'], ['B01.050.500.131.365.060.050'], ['E05.196.181.400.300'], ['B03.280', 'B03.440.475.100'], ['D04.345.566.297', 'D12.644.641.297'], ['Z01.639.760.590.373'], ['E05.940.402', 'G07.225.500', 'G07.690.773.875.750', 'G07.690.936.500.750'], ['E05.196.867.519'], ['B01.050.500.644'], ['D04.345.566', 'D12.644.641'],... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Time to improve statin prescription guidelines in low-risk patients? | Background The challenge of the primary prevention of cardiovascular disease (CVD) is to identify patients who would benefit from treatment with statins. Statins are currently prescribed to many patients, even those at a low 10-year risk of CVD. These latter patients may not be eligible for statins according to current... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Biomarkers', 'Cardiovascular Diseases', 'Dyslipidemias', 'Eligibility Determination', 'Female', 'Guideline Adherence', 'Humans', 'Hydroxymethylglutaryl-CoA Reductase Inhibitors', 'Lipids', 'Logistic Models', 'Male', 'Middle Aged', 'Multivariate Analysis', 'Netherlan... | 28,429,651 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D23.101'], ['C14'], ['C18.452.584.500'], ['N04.452.264'], ['N04.761.337', 'N05.715.360.395'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.519.186.071.202.370', 'D27.505.519.389.370', 'D27.505.954.557.500.202.370'], ['D10']... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
CcaR is an autoregulatory protein that binds to the ccaR and cefD-cmcI promoters of the cephamycin C-clavulanic acid cluster in Streptomyces clavuligerus. | The putative regulatory CcaR protein, which is encoded in the beta-lactam supercluster of Streptomyces clavuligerus, has been partially purified by ammonium sulfate precipitation and heparin affinity chromatography. In addition, it was expressed in Escherichia coli, purified as a His-tagged recombinant protein (rCcaR),... | ['Amino Acid Isomerases', 'Bacterial Proteins', 'Cephamycins', 'Clavulanic Acid', 'DNA-Binding Proteins', 'Genes, Bacterial', 'Genes, Regulator', 'Promoter Regions, Genetic', 'Recombinant Fusion Proteins', 'Streptomyces', 'Transcription Factors'] | 12,003,953 | [['D08.811.399.894.200'], ['D12.776.097'], ['D02.065.589.099.249.250', 'D02.886.665.074.250', 'D03.633.100.300.249.250'], ['D02.065.589.099.374.160', 'D03.633.100.300.374.160'], ['D12.776.260'], ['G05.360.340.024.340.364.249', 'G05.360.340.358.024.249', 'G05.360.340.358.207.249'], ['G05.360.340.024.340.425'], ['G02.111... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Therapeutic results and changes in prognosis in patients with multiple myeloma in central and northern Moravia over the past 40 years]. | OBJECTIVE: The objective of the investigation is evaluation of therapeutic results and the development of the prognosis of patients with multiple myeloma (MM) as a result of consecutive changes of therapeutic procedures in patients of central and northern Moravia in the course of the last 40 years.METHODS AND RESULTS: ... | ['Adult', 'Aged', 'Aged, 80 and over', 'Antineoplastic Agents', 'Combined Modality Therapy', 'Female', 'Hematopoietic Stem Cell Transplantation', 'Humans', 'Male', 'Middle Aged', 'Multiple Myeloma', 'Prognosis', 'Retrospective Studies', 'Survival Rate'] | 12,425,200 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.954.248'], ['E02.186'], ['E02.095.147.500.500.500', 'E04.936.225.687.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C04.557.595.500', 'C14.907.454.460', 'C15.378.147.780.650', 'C15.378.463.515.460', 'C20.683.515.84... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Cyclin D1 amplification correlates with early recurrence of squamous cell carcinoma of the tongue. | Amplification of CCND1 was studied in 23 tongue carcinoma patients by fluorescence in situ hybridization (FISH) using a paraffin embedded specimen. All the patients received complete resection of the primary site with or without neck dissection. CCND1 amplification was positive in 13 (56.5%) out of 23 cases. Correlatio... | ['Carcinoma, Squamous Cell', 'Chromosomes, Human, Pair 11', 'Cohort Studies', 'Cyclin D1', 'Female', 'Gene Amplification', 'Humans', 'In Situ Hybridization, Fluorescence', 'Male', 'Middle Aged', 'Neoplasm Recurrence, Local', 'Prognosis', 'Retrospective Studies', 'Survival Rate', 'Tongue Neoplasms'] | 11,566,495 | [['C04.557.470.200.400', 'C04.557.470.700.400'], ['A11.284.187.520.300.325.355', 'G05.360.162.520.300.325.355'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['D12.644.360.262.150.100', 'D12.776.167.218.150.100', 'D12.776.476.262.150.100', 'D12.776.624.664.700.100'], ['G05.308.250', 'G... | ['Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Named Groups [M]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Increased brain responses during subjectively-matched mechanical pain stimulation in fibromyalgia patients as evidenced by MEG. | OBJECTIVE: The precise pathophysiology of fibromyalgia, a syndrome characterized by chronic widespread pain, remains to be clarified. When subjected to the same amount of stimulation, patients show enhanced brain responses as compared to controls, providing evidence of central pain augmentation in this syndrome. We aim... | ['Adult', 'Brain', 'Data Interpretation, Statistical', 'Evoked Potentials', 'Female', 'Fibromyalgia', 'Humans', 'Magnetic Resonance Imaging', 'Magnetoencephalography', 'Pain Measurement', 'Pain Threshold', 'Physical Stimulation'] | 23,121,899 | [['M01.060.116'], ['A08.186.211'], ['E05.245.380', 'E05.318.740.300', 'L01.313.500.750.190.380', 'N05.715.360.750.300', 'N06.850.520.830.300'], ['G07.265.216.500', 'G11.561.200.500'], ['C05.651.324', 'C05.799.321', 'C10.668.491.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['E01.370.3... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Clinical factors that affect blood gases in non-smoking women with chronic liver disease. | Chronic liver disease is often accompanied by hypoxaemia. We investigated the clinical factors that were related to the arterial oxygen tension (PaO2) in 40 women, all non-smokers with chronic liver disease. They were positive for hepatitis C virus (HCV) antibody and had no evidence of cardiopulmonary disease. Arterial... | ['Adult', 'Aged', 'Aged, 80 and over', 'Blood Gas Analysis', 'Capillaries', 'Endotoxins', 'Female', 'Hepatitis C, Chronic', 'Humans', 'Indocyanine Green', 'Liver', 'Middle Aged', 'Oxygen', 'Pulmonary Circulation', 'Regression Analysis'] | 9,519,226 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E01.370.225.124.100.100', 'E01.370.386.700.100', 'E05.200.124.100.100'], ['A07.015.461.165'], ['D23.946.123.329'], ['C01.221.250.750.120', 'C01.925.440.440.120', 'C01.925.782.350.350.120', 'C06.552.380.350.120', 'C06.552.380.705.440.120'], ['B01.050.150.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Spatial working memory for clustered and linear configurations of sites in a virtual reality foraging task. | Two experiments using an immersive virtual reality foraging environment determined the spatial strategies spontaneously deployed by people in a foraging task and the effects on immediate serial recall of trajectories though the foraging space, which could conform or violate specific organisational constraints. People b... | ['Adolescent', 'Adult', 'Cluster Analysis', 'Female', 'Humans', 'Linear Models', 'Male', 'Memory, Short-Term', 'Neuropsychological Tests', 'Reaction Time', 'Space Perception', 'User-Computer Interface', 'Young Adult'] | 22,802,028 | [['M01.060.057'], ['M01.060.116'], ['E05.318.740.250', 'N05.715.360.750.200', 'N06.850.520.830.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.500', 'E05.318.740.750.425', 'E05.599.835.750', 'N05.715.360.750.530.460', 'N05.715.360.750.695.460', 'N06.850.520.830.500.500', 'N06.850.520.830.750.4... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Going flat: examining heterogeneity in the soda-obesity relationship by subgroup and place of birth among Asian Americans. | OBJECTIVE: To determine if the association between soda consumption and obesity is uniform among Asian-American population subgroups.DESIGN: We conducted multivariate logistic regression analyses on odds of being obese among seven Asian subgroups and by place of birth using data from the 2009 California Health Intervie... | ['Acculturation', 'Adult', 'Asian Americans', 'California', 'Carbonated Beverages', 'Chronic Disease', 'Cross-Sectional Studies', 'Emigrants and Immigrants', 'European Continental Ancestry Group', 'Female', 'Health Surveys', 'Humans', 'Logistic Models', 'Male', 'Middle Aged', 'Obesity', 'Public Health', 'Residence Char... | 28,233,506 | [['I01.076.201.450.050', 'I01.880.853.100.079'], ['M01.060.116'], ['M01.686.508.200.100', 'M01.686.754.225'], ['Z01.107.567.875.580.200', 'Z01.107.567.875.760.200'], ['G07.203.100.300', 'J02.200.300'], ['C23.550.291.500'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['M01.189'], ['M01... | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Named Groups [M]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Disciplines a... | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
The formation of alveoli in rat lung during the third and fourth postnatal weeks: effect of hyperoxia, dexamethasone, and deferoxamine. | Terminal gas-exchange units in the lung of many species are, at birth, relatively large structures termed saccules. Saccules septate postnatally forming smaller units that constitute the final alveoli. In the rat, septation occurs intensively during the first 2 postnatal wk after which it has been considered to stop. T... | ['Age Factors', 'Animals', 'Bronchopulmonary Dysplasia', 'Deferoxamine', 'Dexamethasone', 'Elastin', 'Humans', 'Infant, Newborn', 'Lung Volume Measurements', 'Oxygen', 'Pulmonary Alveoli', 'Pulmonary Gas Exchange', 'Rats', 'Rats, Sprague-Dawley'] | 8,134,176 | [['N05.715.350.075', 'N06.850.490.250'], ['B01.050'], ['C08.381.520.750.500', 'C16.614.521.125'], ['D02.092.570.394.265', 'D02.241.511.372.265'], ['D04.210.500.745.432.769.344', 'D04.210.500.908.238'], ['D05.750.078.421', 'D12.776.860.300.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['E0... | ['Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A text matching method to facilitate the validation of frequent order sets obtained through data mining. | In order to compare order sets discovered using a data mining algorithm with existing order sets, we developed an order matching tool based on Oracle Text. The tool includes both automated searching and manual review processes. The comparison between the automated process and the manual review process indicates that th... | ['Algorithms', 'Information Storage and Retrieval', 'Medical Order Entry Systems'] | 17,238,501 | [['G17.035', 'L01.224.050'], ['L01.313.500.750.280', 'L01.470'], ['L01.313.500.750.300.695.600', 'N04.452.442.452.452.500', 'N04.452.515.360.500', 'N04.452.859.564.650.500']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Health Care [N]'] | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Akt2 (Protein Kinase B Beta) Stabilizes ATP7A, a Copper Transporter for Extracellular Superoxide Dismutase, in Vascular Smooth Muscle: Novel Mechanism to Limit Endothelial Dysfunction in Type 2 Diabetes Mellitus. | OBJECTIVE: Copper transporter ATP7A (copper-transporting/ATPase) is required for full activation of SOD3 (extracellular superoxide dismutase), which is secreted from vascular smooth muscle cells (VSMCs) and anchors to endothelial cell surface to preserve endothelial function by scavenging extracellular superoxide. We r... | ['Animals', 'Aorta, Thoracic', 'Cells, Cultured', 'Copper-Transporting ATPases', 'Diabetes Mellitus, Experimental', 'Diabetes Mellitus, Type 2', 'Diabetic Angiopathies', 'Endothelium, Vascular', 'Enzyme Stability', 'Female', 'Humans', 'Hypoglycemic Agents', 'Insulin', 'Male', 'Mesenteric Arteries', 'Mice, Inbred C57BL'... | 29,301,787 | [['B01.050'], ['A07.015.114.056.372'], ['A11.251'], ['D08.811.277.040.025.314.500', 'D12.776.157.530.450.250.578.750', 'D12.776.157.530.813.500', 'D12.776.543.585.450.250.578.750', 'D12.776.543.585.813.500'], ['C18.452.394.750.074', 'C19.246.240', 'E05.598.500.374'], ['C18.452.394.750.149', 'C19.246.300'], ['C14.907.32... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Preoperative undetectable serum thyroglobulin in differentiated thyroid carcinoma: incidence, causes and management strategy. | BACKGROUND: In recent years serum thyroglobulin (Tg) measurement during thyroxine (T4) treatment and/or after stimulation by endogenous TSH or recombinant human TSH (rhTSH) has eclipsed other diagnostic procedures in managing patients with differentiated thyroid cancer (DTC). However, preoperative undetectable Tg was r... | ['Adenocarcinoma, Follicular', 'Adenoma, Oxyphilic', 'Adult', 'Aged', 'Biomarkers', 'Carcinoma, Papillary', 'Case-Control Studies', 'Female', 'Follow-Up Studies', 'Humans', 'Immunoradiometric Assay', 'Incidence', 'Iodine Radioisotopes', 'Male', 'Middle Aged', 'Neoplasm Recurrence, Local', 'Radiopharmaceuticals', 'Retro... | 17,561,976 | [['C04.557.470.200.025.060'], ['C04.557.470.035.140'], ['M01.060.116'], ['M01.060.116.100'], ['D23.101'], ['C04.557.470.200.360', 'C04.557.470.700.360'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Vitamin B(12) incorporated with multiwalled carbon nanotube composite film for the determination of hydrazine. | Electrochemically active composite film containing multiwalled carbon nanotubes (MWCNTs) and vitamin B(12) was synthesized on glassy carbon, gold, and indium tin oxide electrodes by the potentiodynamic method. The presence of MWCNTs in the composite film (MWCNT-B(12)) modified electrode mediates vitamin B(12)'s redox r... | ['Carbon', 'Catalysis', 'Electrochemical Techniques', 'Electrodes', 'Gold', 'Hydrazines', 'Hydrogen-Ion Concentration', 'Nanotubes, Carbon', 'Oxidation-Reduction', 'Tin Compounds', 'Vitamin B 12'] | 20,920,459 | [['D01.268.150'], ['G02.130'], ['E05.301'], ['E07.305.250'], ['D01.268.556.322', 'D01.268.956.186', 'D01.552.544.322'], ['D02.442'], ['G02.300'], ['D01.268.150.250.500', 'J01.637.512.850.500'], ['G02.700', 'G03.295.531'], ['D01.935'], ['D03.383.129.578.840.437.777', 'D03.633.400.909.437.777', 'D04.345.783.437.777']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
[Legionella pneumonia which occurred in a private whirlpool bath user]. | A 88 year old female with active rheumatoid arthritis treated by low dose of prednisolone and methotrexate was admitted to our hospital because of severe bilateral pulmonary infiltration and acute respiratory distress syndrome. On admission, she had consciousness disturbance and was intubated because of severe respirat... | ['Aged', 'Aged, 80 and over', 'Arthritis, Rheumatoid', 'Baths', 'Female', 'Humans', 'Legionella pneumophila', "Legionnaires' Disease", 'Water Microbiology'] | 15,560,380 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['C05.550.114.154', 'C05.799.114', 'C17.300.775.099', 'C20.111.199'], ['E02.056.110'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B03.440.400.425.450.450.500', 'B03.660.250.460.460.580'], ['C01.150.252.400.500.501', 'C01.748.382.380', 'C08.730.382.380'], ['H01.158.... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Shear bond strength of composite resin and amalgam adhesive systems to dentin. | PURPOSE: To determine the effects of several multi-purpose dental adhesive systems on the shear bond strength of both composite resin (Herculite XRV) and amalgam (Tytin) to dentin.MATERIALS AND METHODS: 160 extracted human molar teeth were randomly assigned to 16 treatment groups (n = 10/group), embedded in resin, and ... | ['Acid Etching, Dental', 'Analysis of Variance', 'Composite Resins', 'Dental Alloys', 'Dental Amalgam', 'Dental Bonding', 'Dental Restoration, Permanent', 'Dental Stress Analysis', 'Dentin-Bonding Agents', 'Humans', 'Materials Testing', 'Molar', 'Resin Cements', 'Surface Properties', 'Tensile Strength'] | 10,477,994 | [['E06.931.475.111'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['D05.750.716.822.308', 'D25.339.816.500', 'D25.720.716.822.308', 'J01.637.051.339.816.500', 'J01.637.051.720.716.822.308'], ['D25.339.208', 'J01.637.051.339.208'], ['D25.339.208.291', 'J01.637.051.339.208.291'], ['E06.095'], ['E06... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Swine adipose stromal cells loaded with recombinant bovine herpesvirus 4 virions expressing a foreign antigen induce potent humoral immune responses in pigs. | Increasingly effective vaccination strategies are needed to counteract the high incidence of contagious diseases associated with intensive swine breeding. Recombinant viral vaccines are a promising new avenue in this direction. Key features of viral vectors suitable for immunoprophylaxis are safety, ease of manipulatio... | ['Animals', 'Antibodies, Neutralizing', 'Antibodies, Viral', 'Antigens, Viral', 'Diarrhea Viruses, Bovine Viral', 'Genetic Vectors', 'Herpesvirus 4, Bovine', 'Recombinant Proteins', 'Stromal Cells', 'Swine', 'Vaccination', 'Vaccines, Synthetic', 'Viral Vaccines'] | 21,115,049 | [['B01.050'], ['D12.776.124.486.485.114.244', 'D12.776.124.790.651.114.244', 'D12.776.377.715.548.114.244'], ['D12.776.124.486.485.114.254', 'D12.776.124.790.651.114.254', 'D12.776.377.715.548.114.254'], ['D23.050.327'], ['B04.820.578.344.700.150'], ['G05.360.337'], ['B04.280.210.400.700.300', 'B04.280.382.400.700.300'... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Endoscopic ultrasonography with fine-needle aspiration: an accurate and simple diagnostic modality for sarcoidosis. | BACKGROUND AND STUDY AIMS: Sarcoidosis is a chronic multisystem granulomatous disease that is often diagnosed after a finding of hilar and mediastinal lymphadenopathy on a chest radiograph. This often requires further evaluation by transbronchial biopsy or other clinical parameters. The present study is a descriptive, ... | ['Adult', 'Aged', 'Biopsy, Needle', 'Bronchoscopy', 'Diagnosis, Differential', 'Endosonography', 'Feasibility Studies', 'Female', 'Follow-Up Studies', 'Humans', 'Lymph Nodes', 'Male', 'Mediastinal Diseases', 'Middle Aged', 'Reproducibility of Results', 'Retrospective Studies', 'Sarcoidosis', 'Tomography, X-Ray Computed... | 10,433,047 | [['M01.060.116'], ['M01.060.116.100'], ['E01.370.225.500.384.100.119', 'E01.370.225.998.054.119', 'E01.370.388.100.100', 'E04.074.119', 'E04.665.100', 'E05.200.500.384.100.119', 'E05.200.998.054.119', 'E05.242.384.100.119'], ['E01.370.386.105', 'E01.370.388.250.100', 'E04.502.250.100', 'E04.928.600.080'], ['E01.171'], ... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Enhancement of bone mineral density and body mass in newborn chickens by in ovo injection of ionic-hydroxyapatite nanoparticles of bacterial origin. | Using non-drug, non-surgical treatments for improving bone mineral diseases in newborn babies is an important topic for neonatologists. The present study introduces bacterial synthesized ionic nano-hydroxyapatite (Bio-HA) for the development of bone mineral density in the chicken embryo model. In vitro cytotoxicity ana... | ['Animals', 'Body Weight', 'Bone Density', 'Calcification, Physiologic', 'Chickens', 'Durapatite', 'Enterobacter aerogenes', 'Humans', 'Injections', 'Ions', 'Kidney', 'Liver', 'MCF-7 Cells', 'Nanoparticles'] | 30,671,631 | [['B01.050'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['G11.427.100'], ['G07.345.155.500', 'G07.345.500.325.377.625.050.500.175', 'G11.427.578.050.500.175'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['D01.029.260.700.675... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Long term survival in a patient with recurrent malignant glioma treated with intratumoral infusion of an IL4-targeted toxin (NBI-3001). | Intratumoral infusion of a recombinant targeted toxin (NBI-3001) consisting of the receptor binding domain of human interleukin 4 (IL-4) and Pseudomonas aeruginosa exotoxin A is an investigational treatment for malignant brain tumors. This 27-year-old male patient presented with a recurrent malignant glioma WHO grade I... | ['Adult', 'Bacterial Toxins', 'Brain Neoplasms', 'Exotoxins', 'Glioma', 'Humans', 'Injections, Intralesional', 'Interleukin-4', 'Magnetic Resonance Imaging', 'Male'] | 15,015,787 | [['M01.060.116'], ['D23.946.123'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['D23.946.350'], ['C04.557.465.625.600.380', 'C04.557.470.670.380', 'C04.557.580.625.600.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.267.530.430'], ['D12.644.276.374.465.186', 'D12.776.467.374.465.178... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Mononucleosis caused by cytomegalovirus]. | Sixteen cases of mononucleosis due to cytomegalovirus, are presented. The selection of patients was based on clinical criteria. Symptoms are compared with another series of patients affected with mononucleosis by Epstein-Barr virus. We have not found differences comparing the fever, cervical adenopathies and faringoami... | ['Child', 'Child, Preschool', 'Cytomegalovirus', 'Cytomegalovirus Infections', 'Diagnosis, Differential', 'Female', 'Hepatomegaly', 'Herpesvirus 4, Human', 'Humans', 'Infant', 'Infectious Mononucleosis', 'Male'] | 2,158,261 | [['M01.060.406'], ['M01.060.406.448'], ['B04.280.382.150.150'], ['C01.925.256.466.245'], ['E01.171'], ['C06.552.416', 'C23.300.775.525'], ['B04.280.210.400.500.450', 'B04.280.382.400.500.400', 'B04.613.204.500.500.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['C01.925.256.466.313.400', 'C15.... | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Global mapping of nucleic acid conformational space: dinucleoside monophosphate conformations and transition pathways among conformational classes. | A global conformational space of 6253 dinucleoside monophosphate (DMP) units consisting of RNA and DNA (free and protein/drug-bound) was 'mapped' using high resolution crystal structures cataloged in the Nucleic Acid Database (NDB). The torsion angles of each DMP were clustered in a reduced three-dimensional space usin... | ['Algorithms', 'DNA', 'DNA-Binding Proteins', 'Dinucleoside Phosphates', 'Models, Molecular', 'Molecular Structure', 'Nucleic Acid Conformation', 'Principal Component Analysis', 'RNA', 'RNA-Binding Proteins'] | 14,500,824 | [['G17.035', 'L01.224.050'], ['D13.444.308'], ['D12.776.260'], ['D13.695.250'], ['E05.599.595'], ['G02.111.570', 'G02.466'], ['G02.111.570.820.486', 'G05.360.580'], ['E05.318.740.562'], ['D13.444.735'], ['D12.776.157.725', 'D12.776.664.962']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
High-field MR surface-coil imaging of the hand and wrist. Part II. Pathologic correlations and clinical relevance. | High-resolution magnetic resonance (MR) images of the hands and wrists of 12 patients with a variety of suspected pathologic conditions were obtained at 1.5 T using a prototype surface coil. Lesions included ganglions, rheumatoid arthritis, carpal fractures, carpal tunnel syndrome, and arteriovenous malformations. In t... | ['Adult', 'Arteriovenous Malformations', 'Arthritis, Rheumatoid', 'Carpal Bones', 'Carpal Tunnel Syndrome', 'Female', 'Fractures, Bone', 'Hand', 'Humans', 'Magnetic Resonance Spectroscopy', 'Synovial Cyst', 'Tendon Injuries', 'Wrist'] | 3,715,026 | [['M01.060.116'], ['C14.240.850.750', 'C14.907.150', 'C16.131.240.850.750'], ['C05.550.114.154', 'C05.799.114', 'C17.300.775.099', 'C20.111.199'], ['A02.835.232.087.319.150'], ['C10.668.829.500.500.200', 'C10.668.829.550.200', 'C26.844.150.206'], ['C26.404'], ['A01.378.800.667'], ['B01.050.150.900.649.313.988.400.112.4... | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Stafne's bone cavity in the anterior mandible: report of a case. | An unusual case of Stafne's bone cavity which presented in the canine-premolar region of the mandible is presented. The diagnosis was confirmed using CT and sialography. | ['Humans', 'Jaw Cysts', 'Male', 'Mandibular Diseases', 'Middle Aged', 'Sialography', 'Tomography, X-Ray Computed'] | 2,387,472 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.182.089.530', 'C05.500.470', 'C07.320.450'], ['C05.500.607', 'C07.320.610'], ['M01.060.116.630'], ['E01.370.350.700.720.793', 'E01.370.372.700', 'E06.342.764.793'], ['E01.370.350.350.810', 'E01.370.350.600.350.700.810', 'E01.370.350.700.700.810', 'E01.370.350.700.... | ['Organisms [B]', 'Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Clinical characteristics of severe community-acquired pneumonia among younger patients: an analysis of 18 years at a community hospital. | Unlike elderly patients with community-acquired pneumonia whose outcomes are markedly affected by their background characteristics, it appears that the severity of the infection itself contributes to outcomes in younger patients with community-acquired pneumonia. In order to identify clinical characteristics of severe ... | ['Adult', 'Analysis of Variance', 'Anti-Bacterial Agents', 'Community-Acquired Infections', 'Female', 'Hospitals, Community', 'Humans', 'Japan', 'Male', 'Middle Aged', 'Pneumonia, Bacterial', 'Retrospective Studies', 'Risk Factors'] | 24,951,291 | [['M01.060.116'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['D27.505.954.122.085'], ['C01.234'], ['N02.278.421.306'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.474.463', 'Z01.639.595'], ['M01.060.116.630'], ['C01.150.252.620', 'C01.748.610.540', 'C08.381.677.540', 'C08.730.610... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Complete remission of cerebral endometriosis with dienogest: a case report. | The most recent evidences suggest the use of progesterone mimicking drugs for the treatment of endometriosis. Particularly, dienogest has been largely tested. However, the standard treatment of extra-pelvic endometriosis is debated. Particularly, cerebral localization of endometriosis is a very rare clinical condition.... | ['Adult', 'Brain', 'Brain Diseases', 'Endometriosis', 'Female', 'Hormone Antagonists', 'Humans', 'Magnetic Resonance Imaging', 'Nandrolone', 'Treatment Outcome'] | 29,676,597 | [['M01.060.116'], ['A08.186.211'], ['C10.228.140'], ['C13.351.500.163'], ['D06.347', 'D27.505.696.399.450'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['D04.210.500.365.415.638', 'D06.472.334.851.968.976'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800']] | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Can radicality of surgery be safely modulated on the basis of MRI and PET/CT imaging in locally advanced cervical cancer patients administered preoperative treatment? | BACKGROUND: The goal of this study was to prospectively analyze the diagnostic performances of magnetic resonance imaging (MRI) and positron emission tomography (PET)/computed tomography (CT) in predicting pathologically assessed residual disease in a large, single-institution series of locally advanced cervical cancer... | ['Adult', 'Aged', 'Female', 'Humans', 'Lymphatic Metastasis', 'Magnetic Resonance Imaging', 'Middle Aged', 'Multimodal Imaging', 'Neoadjuvant Therapy', 'Neoplasm, Residual', 'Positron-Emission Tomography', 'Sensitivity and Specificity', 'Tomography, X-Ray Computed', 'Uterine Cervical Neoplasms'] | 21,720,998 | [['M01.060.116'], ['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.697.650.560', 'C23.550.727.650.560'], ['E01.370.350.825.500'], ['M01.060.116.630'], ['E01.370.350.567'], ['E02.186.450'], ['C04.697.700', 'C23.550.727.700'], ['E01.370.350.350.800.700', 'E01.370.350.600.350.800.399', 'E01.370.... | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Simultaneous inference on treatment effects in survival studies with factorial designs. | A clinical trial with a 2?2 factorial design involves randomization of subjects to treatment A or A‾ and, within each group, further randomization to treatment B or B‾. Under this design, one can assess the effects of treatments A and B on a clinical endpoint using all patients. One may additionally compare treatment A... | ['Alcoholism', 'Animals', 'Clinical Trials as Topic', 'Computer Simulation', 'Humans', 'Research Design', 'Survival Analysis', 'Treatment Outcome'] | 26,991,149 | [['C25.775.100.250', 'F03.900.100.350'], ['B01.050'], ['E05.318.372.250.250', 'N05.715.360.330.250.250', 'N06.850.520.450.250.250'], ['L01.224.160'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.581.500', 'H01.770.644.728'], ['E05.318.740.998', 'N05.715.360.750.795', 'N06.850.520.830.998'], ['E01.789.800', 'N... | ['Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Information Science [L]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Experimental granulomatous inflammation: the ultrastructure of the granuloma induced by injection of tubercle bacilli into Freund adjuvant-sensitised guinea-pigs. | Injection of killed tubercle bacilli into a sensitised guinea pig produces a characteristic biphasic response with the development of an organised epithelioid cell granuloma in the second phase. Previous sensitisation to tubercle bacilli is a requirement for development of the organised granulomatous response. The main... | ['Animals', 'Epithelium', "Freund's Adjuvant", 'Granuloma', 'Guinea Pigs', 'Hypersensitivity, Delayed', 'Microscopy, Electron', 'Monocytes', 'Skin', 'Skin Diseases', 'Time Factors', 'Tuberculin'] | 536,882 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Influence of HIV-related immunodeficiency on the histopathology of chronic hepatitis C]. | OBJECTIVE: There is substantial evidence demonstrating the aggravating effect of human immunodeficiency virus (HIV) infection on the progression of chronic hepatitis C virus (HCV) infection. There is however, little data on the affect of certain factors which could affect liver pathology findings in patients with conco... | ['Adult', 'Biopsy', 'CD4-Positive T-Lymphocytes', 'CD8-Positive T-Lymphocytes', 'Female', 'HIV Infections', 'Hepatitis C, Chronic', 'Humans', 'Immunity, Cellular', 'Liver', 'Lymphocyte Count', 'Male', 'Retrospective Studies'] | 9,819,599 | [['M01.060.116'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['A11.118.637.555.567.569.200', 'A15.145.229.637.555.567.569.200', 'A15.382.490.555.567.569.200'], ['A11.118.637.555.567.569.220', 'A15.145.229.637.555.567.569... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Conservation and diversity of microRNA-associated copper-regulatory networks in Populus trichocarpa. | Plants develop important regulatory networks to adapt to the frequently-changing availability of copper (Cu). However, little is known about miRNA-associated Cu-regulatory networks in plant species other than Arabidopsis. Here, we report that Cu-responsive miRNAs in Populus trichocarpa (Torr. & Gray) include not only c... | ['Copper', 'Gene Expression Regulation, Plant', 'MicroRNAs', 'Plant Proteins', 'Populus', 'Promoter Regions, Genetic'] | 22,013,976 | [['D01.268.556.195', 'D01.268.956.170', 'D01.552.544.195'], ['G05.308.375'], ['D13.150.650.319', 'D13.444.735.150.319', 'D13.444.735.790.552.500'], ['D12.776.765'], ['B01.650.940.800.575.912.250.859.797.875.453'], ['G02.111.570.080.689.675', 'G05.360.080.689.675', 'G05.360.340.024.340.137.750.680']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bar-code-assisted medication administration: a method for predicting repackaging resource needs. | PURPOSE: Results of a study at two hospitals to validate and test systems for bar-code-assisted medication administration (BCMA) are reported, including data on bar-code scanning failures and BCMA-related staff resource needs.METHODS: To prepare for BCMA implementation, pharmacy inventories at the two study sites were ... | ['Algorithms', 'Drug Labeling', 'Drug Packaging', 'Drug-Related Side Effects and Adverse Reactions', 'Electronic Data Processing', 'Hospitals', 'Humans', 'Medication Errors', 'Medication Systems, Hospital', 'Pharmaceutical Preparations', 'Reproducibility of Results', 'United States'] | 23,292,270 | [['G17.035', 'L01.224.050'], ['E05.916.310', 'J01.576.655.750.321.400', 'J01.576.761.300.400'], ['E05.916.320', 'J01.576.655.750.321', 'J01.576.761.300'], ['C25.100'], ['L01.224.085'], ['N02.278.421'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.529', 'N02.421.450.500'], ['N04.452.442.452.675', 'N04.452.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 |
Safety of one-step conversion of gastric band to sleeve: a comparative analysis of ACS-NSQIP data. | BACKGROUND: The conversion rate of laparoscopic adjustable gastric banding (LAGB) to laparoscopic sleeve gastrectomy (LSG) has increased during recent years. The safety profile of one-step conversion of LAGB to LSG is not clear from the current literature.METHODS: Using the database of the American College of Surgeons ... | ['Adult', 'Cohort Studies', 'Datasets as Topic', 'Female', 'Gastrectomy', 'Gastroplasty', 'Humans', 'Laparoscopy', 'Male', 'Middle Aged', 'Obesity, Morbid', 'Quality Improvement', 'Treatment Outcome', 'United States', 'Weight Loss'] | 25,614,353 | [['M01.060.116'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E05.318.308.056', 'L01.313.500.750.300.188.400.500', 'L01.399.250.224', 'L01.470.750.750.431', 'N05.715.360.300.224', 'N06.850.520.308.056'], ['E04.210.419'], ['E02.650.500.062.750', 'E04.062.750', 'E04.210.485'], ['B01.0... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Information Science [L]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 |
Postsurgical use of amplatzer septal occluder in cyanotic patients with pulmonary atresia/intact ventricular septum: significance of cor triatriatum dexter and dilated right atrium. | Percutaneous closure of secundum atrial septal defects (ASDs) has been shown to be safe and effective. However, its role after surgery in patients with cyanotic congenital heart disease who may have associated cor triatriatum dexter and a dilated right atrium has not been established. This article reports on successful... | ['Child, Preschool', 'Cor Triatriatum', 'Cyanosis', 'Dilatation, Pathologic', 'Echocardiography, Transesophageal', 'Heart Atria', 'Heart Septal Defects, Atrial', 'Humans', 'Infant', 'Male', 'Prostheses and Implants', 'Pulmonary Atresia'] | 11,025,573 | [['M01.060.406.448'], ['C14.240.400.200', 'C14.280.400.200', 'C16.131.240.400.200'], ['C23.888.248'], ['C23.300.325'], ['E01.370.350.130.750.235', 'E01.370.350.850.220.235', 'E01.370.370.380.220.235'], ['A07.541.358'], ['C14.240.400.560.375', 'C14.280.400.560.375', 'C16.131.240.400.560.375'], ['B01.050.150.900.649.313.... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Evaluation of anti-inflammatory activity of selected legumes from Pakistan: in vitro inhibition of cyclooxygenase-2. | Crude methanolic extracts of selected legumes namely, black gram (Vigna mungo L.), green gram (Vigna radiata (L.) R. Wilczek ), soybean (Glycine max (L.) Merr.) and lentil (Lens culinaris Medik.) were investigated for anti-inflammatory effects, using COX-2 producing PGE(2) inhibitory assay. Percentage inhibition observ... | ['Cyclooxygenase 2', 'Cyclooxygenase 2 Inhibitors', 'Dinoprostone', 'Dose-Response Relationship, Drug', 'Fabaceae', 'Humans', 'Lens Plant', 'Methanol', 'Pakistan', 'Plant Extracts', 'Plants, Medicinal', 'Recombinant Proteins', 'Solvents', 'Soybeans'] | 23,261,746 | [['D08.811.600.720.750'], ['D27.505.519.389.310.500', 'D27.505.696.663.850.014.040.500.500.500', 'D27.505.954.158.030.500.500', 'D27.505.954.329.030.500.500'], ['D10.251.355.255.550.250.200', 'D23.469.050.175.725.250.200'], ['G07.690.773.875', 'G07.690.936.500'], ['B01.650.940.800.575.912.250.401'], ['B01.050.150.900.6... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Comparison of smears and cell blocks in the fine needle aspiration diagnosis of recurrent gynecologic malignancies. | A retrospective, seven-year study was conducted to evaluate the value of cell blocks as an adjunct to smears in the fine needle aspiration (FNA) diagnosis of recurrent gynecologic malignancies. Eighty-four FNAs were performed on patients with previously diagnosed malignancies of the cervix (39 cases), ovary (27), uteru... | ['Biopsy, Needle', 'Cytodiagnosis', 'Female', 'Genital Neoplasms, Female', 'Humans', 'Paraffin Embedding', 'Recurrence', 'Retrospective Studies', 'Staining and Labeling'] | 1,719,722 | [['E01.370.225.500.384.100.119', 'E01.370.225.998.054.119', 'E01.370.388.100.100', 'E04.074.119', 'E04.665.100', 'E05.200.500.384.100.119', 'E05.200.998.054.119', 'E05.242.384.100.119'], ['E01.370.225.500.384', 'E05.200.500.384', 'E05.242.384'], ['C04.588.945.418', 'C13.351.937.418'], ['B01.050.150.900.649.313.988.400.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Ionized magnesium and calcium levels in umbilical cord serum of pregnant women with transient hypertension during labor. | Using a new ion selective electrode (ISE) to measure ionized magnesium (IMg2+), we compared levels of IMg2+ with total magnesium (TMg) and serum ionized calcium levels (ICa2+) in umbilical arterial and venous serum of 13 parturients who developed transient hypertension in labor with levels in 38 who remained normotensi... | ['Calcium', 'Female', 'Fetal Blood', 'Humans', 'Hypertension', 'Labor, Obstetric', 'Magnesium', 'Pregnancy', 'Pregnancy Complications, Cardiovascular'] | 8,343,240 | [['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['A12.207.152.200', 'A15.145.300', 'A16.378.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['G08.686.784.769.326'], ['D01.268.552.437', 'D01.268.557.500', 'D01.552.547.500'], ['G08.686.784.769'], ['C13.703.634', 'C14.583']] | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The psychological distress of the young driver: a brief report. | The objective of the research was to explore the role of psychological distress in the self-reported risky driving of young novice drivers. A cross-sectional online survey incorporating Kessler's Psychological Distress Scale and the Behaviour of Young Novice Drivers Scale was completed by 761 tertiary students aged 17-... | ['Adolescent', 'Adult', 'Automobile Driving', 'Cross-Sectional Studies', 'Female', 'Humans', 'Internet', 'Male', 'Queensland', 'Regression Analysis', 'Risk Factors', 'Risk-Taking', 'Self Report', 'Stress, Psychological', 'Students', 'Young Adult'] | 21,586,402 | [['M01.060.057'], ['M01.060.116'], ['I03.125'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.230.110.500'], ['Z01.639.100.937', 'Z01.678.100.373.937'], ['E05.318.740.750', 'N05.715.360.750.695', 'N06.850.520.830.750'], ['E05.31... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Information Science [L]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
Creating bidirectional conduction block in the cavotricuspid isthmus by cryothermal ablation with a short freeze time: Insight from the results with a 2-minute freeze cycle. | BACKGROUND: Optimal freeze doses are unknown during cryothermal cavo-tricuspid isthmus (CTI) ablation. This study aimed to evaluate the feasibility of 2-minute freeze doses for CTI ablation.METHODS: Forty-eight consecutive patients undergoing cryothermal CTI ablation following pulmonary vein isolation were enrolled. CT... | ['Aged', 'Atrial Flutter', 'Cryosurgery', 'Electrocardiography', 'Female', 'Heart Conduction System', 'Humans', 'Male', 'Middle Aged', 'Prospective Studies', 'Pulmonary Veins', 'Time Factors', 'Treatment Outcome'] | 27,657,464 | [['M01.060.116.100'], ['C14.280.067.248', 'C23.550.073.248'], ['E04.014.180'], ['E01.370.370.380.240', 'E01.370.405.240'], ['A07.541.409'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['A07.015.908.713']... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Protective effects of pioglitazone on vascular endothelial cell dysfunction induced by high glucose via inhibition of IKKá/â-NFêB signaling mediated by PPARã in vitro. | PIO, a synthetic ligand for PPARã, is used clinically to treat T2DM. However, little is known about its protective effects on endothelium and the underlying mechanisms. In this study, we sought to investigate the protective effects of PIO on endothelium and its probable mechanisms: 95% confluent wild type (WT) HUVECs a... | ['Active Transport, Cell Nucleus', 'Caspase 3', 'Cell Nucleus', 'Cell Survival', 'Cytokines', 'Cytoprotection', 'Dose-Response Relationship, Drug', 'Gene Expression Regulation, Enzymologic', 'Glucose', 'Human Umbilical Vein Endothelial Cells', 'Humans', 'I-kappa B Kinase', 'PPAR gamma', 'Pioglitazone', 'Signal Transduc... | 28,787,583 | [['G03.143.310.100', 'G03.143.700.100'], ['D08.811.277.656.262.500.126.350.300', 'D08.811.277.656.300.200.126.350.300', 'D12.644.360.075.405.350.300', 'D12.776.476.075.405.350.300'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['G04.346'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['G07.690.773.500... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Reemergence of gentamicin-susceptible strains of methicillin-resistant Staphylococcus aureus in France: a phylogenetic approach. | The reemergence of gentamicin-susceptible (Gen(s)) methicillin-resistant Staphylococcus aureus (MRSA) isolates in France between 1992 and 1996 was investigated using a phylogenetic approach (multiprimer randomly amplified polymorphic DNA typing). Eighty-six percent (65 of 85) of the French strains were grouped into one... | ['Anti-Bacterial Agents', 'Electrophoresis, Gel, Pulsed-Field', 'France', 'Gentamicins', 'Humans', 'Methicillin Resistance', 'Phylogeny', 'Random Amplified Polymorphic DNA Technique', 'Staphylococcal Infections', 'Staphylococcus aureus'] | 11,376,072 | [['D27.505.954.122.085'], ['E05.196.401.220', 'E05.301.300.220'], ['Z01.542.286'], ['D09.408.051.374'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G06.099.225.500.600.525', 'G06.225.347.500.600.525', 'G07.690.773.984.269.347.500.600.525'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['E05.393.620.500.687', 'E05.... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 |
ARIANE: integration of information databases within a hospital intranet. | Large information systems handle massive volume of data stored in heterogeneous sources. Each server has its own model of representation of concepts with regard to its aims. One of the main problems end-users encounter when accessing different servers is to match their own viewpoint on biomedical concepts with the vari... | ['Computer Communication Networks', 'Database Management Systems', 'Hospital Information Systems', 'Information Storage and Retrieval', 'Local Area Networks', 'Unified Medical Language System', 'User-Computer Interface'] | 9,726,528 | [['L01.224.230.110'], ['L01.224.068', 'L01.224.900.280', 'N04.452.515.110'], ['N04.452.442.452.452', 'N04.452.515.360'], ['L01.313.500.750.280', 'L01.470'], ['L01.224.230.110.600'], ['L01.453.245.945.800'], ['L01.224.900.910']] | ['Information Science [L]', 'Health Care [N]'] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
[The level of double bonds in the blood lipids of lung cancer patients]. | The total unsaturation of lipids in plasma and erythrocytes of patients with lung carcinoma was studied. It was demonstrated that the level of unsaturation of blood lipids had a definite prognostic significance for patients with malignant tumors. More favourable prognosis for patients with lung carcinoma was connected ... | ['Carcinoma, Small Cell', 'Carcinoma, Squamous Cell', 'Erythrocytes', 'Female', 'Humans', 'Lipid Peroxidation', 'Lipids', 'Lung Neoplasms', 'Lymphatic Metastasis', 'Male', 'Middle Aged', 'Prognosis'] | 1,338,002 | [['C04.557.470.200.380'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.111.515', 'G03.295.531.587'], ['D10'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['C04.697.650.560', 'C23.550.727.650.560'], ['... | ['Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Emergence of non-centrosymmetric topological insulating phase in BiTeI under pressure. | The spin-orbit interaction affects the electronic structure of solids in various ways. Topological insulators are one example in which the spin-orbit interaction leads the bulk bands to have a non-trivial topology, observable as gapless surface or edge states. Another example is the Rashba effect, which lifts the elect... | ['Chemistry, Physical', 'Crystallization', 'Electronics', 'Electrons', 'Equipment Design', 'Kinetics', 'Materials Testing', 'Molecular Conformation', 'Pressure', 'Semiconductors'] | 22,334,082 | [['H01.181.529'], ['E05.196.300', 'G02.171'], ['H01.671.293'], ['G01.249.335', 'G01.358.500.750'], ['E05.320'], ['G01.374.661', 'G02.111.490'], ['E05.570'], ['G02.111.570.820'], ['G01.374.715'], ['E07.305.625']] | ['Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Greater fear of reinjury is related to stiffened jump-landing biomechanics and muscle activation in women after ACL reconstruction. | PURPOSE: Fear of reinjury is an important factor in determining who returns to sport following anterior cruciate ligament reconstruction (ACLR). Evidence from other musculoskeletal injuries indicates fear of reinjury may be related to stiffened movement patterns observed in individuals following ACLR. The relationship ... | ['Adaptation, Physiological', 'Adaptation, Psychological', 'Adolescent', 'Adult', 'Anterior Cruciate Ligament Injuries', 'Anterior Cruciate Ligament Reconstruction', 'Biomechanical Phenomena', 'Cross-Sectional Studies', 'Electromyography', 'Exercise Test', 'Fear', 'Female', 'Humans', 'Recurrence', 'Young Adult'] | 29,700,560 | [['G07.025', 'G16.012.500'], ['F01.058'], ['M01.060.057'], ['M01.060.116'], ['C26.558.554.213'], ['E04.555.110.026', 'E04.680.101.026'], ['G01.154.090', 'G01.374.089'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['E01.370.405.255', 'E01.370.530.255'], ['E01.370.370.380.250', 'E01.370... | ['Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Transposition of great arteries with aortopulmonary window: our surgical experience. | BACKGROUND: Transposition of the great arteries with aortopulmonary window is a rare congenital cardiac anomaly. An arterial switch operation with repair of the aortopulmonary window is the preferred operation in this subset. As the tissue between the great arteries is missing, it is considered to be a complex operatio... | ['Abnormalities, Multiple', 'Age Factors', 'Aortopulmonary Septal Defect', 'Child, Preschool', 'Female', 'Follow-Up Studies', 'Hospital Mortality', 'Humans', 'India', 'Infant', 'Infant, Newborn', 'Male', 'Patient Safety', 'Postoperative Complications', 'Risk Assessment', 'Sampling Studies', 'Survival Rate', 'Transposit... | 24,045,073 | [['C16.131.077'], ['N05.715.350.075', 'N06.850.490.250'], ['C14.240.400.560.098', 'C14.280.400.560.098', 'C16.131.240.400.560.098'], ['M01.060.406.448'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['E05.318.308.985.550.400', 'N01.224.935.698.400', 'N06.850.505.400.975.550... | ['Diseases [C]', 'Health Care [N]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Chemocyanin, a small basic protein from the lily stigma, induces pollen tube chemotropism. | In plant reproduction, pollination is an essential process that delivers the sperm through specialized extracellular matrices (ECM) of the pistil to the ovule. Although specific mechanisms of guidance for pollen tubes through the pistil are not known, the female tissues play a critical role in this event. Many studies ... | ['Amino Acid Sequence', 'Chromatography, Gel', 'Chromatography, High Pressure Liquid', 'Chromatography, Ion Exchange', 'Cloning, Molecular', 'DNA Primers', 'Electrophoresis, Polyacrylamide Gel', 'Extracellular Matrix', 'Kinetics', 'Lilium', 'Metalloproteins', 'Molecular Sequence Data', 'Plant Proteins', 'Pollen', 'Sequ... | 14,671,326 | [['G02.111.570.060', 'L01.453.245.667.060'], ['E05.196.181.400.250'], ['E05.196.181.400.300'], ['E05.196.181.400.383'], ['E05.393.220'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['E05.196.401.402', 'E05.301.300.319'], ['A11.284.295.310'], ['G01.374.661', 'G02.111.490'], ['B01.650.940.800.575.912.250.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
New furostanol saponins from the rhizomes of Tupistra chinensis. | Three new furostanol saponins (1-3), including a polyhydroxyl saponin, were isolated from the rhizomes of Tupistra chinensis. The structures of these compounds were identified by NMR, MS spectral data and chemical methods. | ['Chromatography, Thin Layer', 'Hydrolysis', 'Liliaceae', 'Magnetic Resonance Spectroscopy', 'Mass Spectrometry', 'Molecular Structure', 'Plant Extracts', 'Rhizome', 'Saponins', 'Sterols'] | 22,502,647 | [['E05.196.181.400.537'], ['G02.380'], ['B01.650.940.800.575.912.250.618.875.500'], ['E05.196.867.519'], ['E05.196.566'], ['G02.111.570', 'G02.466'], ['D20.215.784.500', 'D26.667'], ['A18.024.937.750', 'A18.400.750'], ['D09.408.782'], ['D04.210.500.247.808', 'D10.570.938']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
VeA is associated with the response to oxidative stress in the aflatoxin producer Aspergillus flavus. | Survival of fungal species depends on the ability of these organisms to respond to environmental stresses. Osmotic stress or high levels of reactive oxygen species (ROS) can cause stress in fungi resulting in growth inhibition. Both eukaryotic and prokaryotic cells have developed numerous mechanisms to counteract and s... | ['Adaptation, Physiological', 'Aflatoxins', 'Aspergillus flavus', 'Catalase', 'DNA, Fungal', 'Fungal Proteins', 'Gene Expression', 'Gene Expression Regulation, Fungal', 'Osmotic Pressure', 'Oxidative Stress', 'Promoter Regions, Genetic', 'Protein Binding', 'Transcription Factors'] | 24,951,443 | [['G07.025', 'G16.012.500'], ['D03.383.663.283.119', 'D03.633.100.150.119', 'D23.946.587.142'], ['B01.300.381.081.170'], ['D08.811.682.732.332'], ['D13.444.308.300'], ['D12.776.354'], ['G05.297'], ['G05.308.330'], ['G01.374.715.578', 'G02.640.249', 'G02.723.661'], ['G03.673', 'G07.775.750'], ['G02.111.570.080.689.675',... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Impact of a switch to fingolimod on depressive symptoms in patients with relapsing multiple sclerosis: An analysis from the EPOC (Evaluate Patient OutComes) trial. | BACKGROUND: Depression is common in patients with multiple sclerosis (MS), may confound evaluation of therapeutic effectiveness and may be impacted by MS-specific treatments.OBJECTIVE: First, to assess the impact on depressive symptoms of a switch to fingolimod versus remaining on an injectable disease-modifying therap... | ['Adolescent', 'Adult', 'Aged', 'Depressive Disorder', 'Disability Evaluation', 'Drug Administration Routes', 'Drug Substitution', 'Female', 'Fingolimod Hydrochloride', 'Humans', 'Immunosuppressive Agents', 'Male', 'Middle Aged', 'Multiple Sclerosis, Relapsing-Remitting', 'Psychiatric Status Rating Scales', 'Treatment ... | 27,206,905 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['F03.600.300'], ['E01.370.400'], ['E02.319.267'], ['E02.319.307.312', 'N02.421.668.778.500.312'], ['D02.033.100.700.350', 'D02.033.455.706.431', 'D02.092.063.700.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.477.656'], ['M01.060.116.630'],... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The method of rodent whole embryo culture using the rotator-type bottle culture system. | Whole embryo culture (WEC) technique has been developed in 1950's by New and his colleagues, and applied for developmental biology (1). Although development and growth of mammalian embryos are critically dependent on the function of the placenta, WEC technique allows us to culture mouse and rat embryos ex vivo conditio... | ['Animals', 'Embryo Culture Techniques', 'Embryo, Mammalian', 'Embryonic Development', 'Female', 'Mice', 'Pregnancy', 'Rats'] | 20,834,217 | [['B01.050'], ['E05.481.500.468'], ['A16.254'], ['G07.345.500.325.180', 'G08.686.784.170.104'], ['B01.050.150.900.649.313.992.635.505.500'], ['G08.686.784.769'], ['B01.050.150.900.649.313.992.635.505.700']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Novel thermal and microwave-assisted facile route to naphthalen-2(1H)-ones via an oxidative alkoxylation-ring-opening protocol. | Several novel 1,1-disubstituted-8-hydroxynaphthalen-2(1H)-ones have been efficiently synthesized via a two-step sequence from 2-hydroxy-1-naphthaldehyde oxime. The methodology involves oxidative ring closure and alkoxylation to 3a-alkoxynaphtho[1,8-de][1,2]oxazin-4(3aH)-ones, followed by thermal ring-opening. Both ther... | ['Catalysis', 'Combinatorial Chemistry Techniques', 'Microwaves', 'Molecular Structure', 'Naphthols', 'Oxidation-Reduction', 'Oximes'] | 19,586,060 | [['G02.130'], ['E05.197.312', 'J01.897.836.249.249'], ['G01.358.500.505.810.500', 'G01.750.250.810.500', 'G01.750.770.721.500'], ['G02.111.570', 'G02.466'], ['D02.455.426.559.847.638.638', 'D04.615.638.638'], ['G02.700', 'G03.295.531'], ['D02.092.570.665']] | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
A chemical switch for controlling viral infectivity. | Chemically triggered molecular switches for controlling the fate and function of biological systems are fundamental to the emergence of synthetic biology and the development of biomedical applications. We here present the first chemically triggered switch for controlling the infectivity of adeno-associated viral (AAV) ... | ['Cell Line, Tumor', 'Dependovirus', 'Genetic Vectors', 'Humans', 'Protein Structure, Secondary', 'Tacrolimus Binding Proteins'] | 25,058,661 | [['A11.251.210.190', 'A11.251.860.180'], ['B04.280.580.650.170'], ['G05.360.337'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.111.570.820.709.600'], ['D08.811.399.325.500.400.700', 'D12.776.543.750.705.400.700', 'D12.776.827.275.700']] | ['Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Sj?gren's syndrome with pseudolymphoma treated with chrysotherapy. | A 72-year-old woman presented with a 10 X 10 cm pseudolymphoma of the lung and Sj?gren's syndrome. She was treated with weekly chrysotherapy for 4 years and had gradual diminution of the lung mass over this period along with normalization of her parotid gland scintiscan. In addition her rheumatoid factor titer (RF) of ... | ['Aged', 'Female', 'Gold Sodium Thiomalate', 'Humans', 'Lung Neoplasms', 'Lymphoma', "Sjogren's Syndrome"] | 6,420,564 | [['M01.060.116.100'], ['D02.241.081.337.463.703.451', 'D02.691.675.500', 'D02.886.489.891.451'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['C04.557.386', 'C15.604.515.569', 'C20.683.515.761'], ['C05.550.114.154.774', 'C05.799.114.774', 'C07.465.815.929.669'... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A biochemical assay for acetylcholinesterase activity in PC12 cells. | This lab describes two biochemical assays: One for measuring acetylcholinesterase activity and one for measuring protein concentration. Students learn how to manipulate small-volume samples, use a standard spectrophotometer or a microplate reader spectrophotometer, construct a standard curve, and normalize data. The la... | ['Acetylcholinesterase', 'Animals', 'Clinical Enzyme Tests', 'Education', 'PC12 Cells', 'Proteins', 'Rats', 'Spectrophotometry'] | 17,632,879 | [['D08.811.277.352.100.170.176'], ['B01.050'], ['E01.370.225.124.200', 'E05.196.427.200', 'E05.200.124.200'], ['I02'], ['A11.251.210.190.750', 'A11.251.860.180.750', 'A11.299.500'], ['D12.776'], ['B01.050.150.900.649.313.992.635.505.700'], ['E05.196.712.726', 'E05.196.867.826']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
Reoperation for parathyroid adenoma: a contemporary experience. | BACKGROUND: We reviewed reoperations for persistent or recurrent sporadic parathyroid adenoma to evaluate and compare our current results and outcomes to our previous experience.METHODS: From 1996 to 2008, 237 patients with persistent or recurrent hyperparathyroidism after failed operation underwent reoperation. Patien... | ['Adenoma', 'Adolescent', 'Adult', 'Aged', 'Female', 'Humans', 'Hypercapnia', 'Hyperparathyroidism', 'Male', 'Middle Aged', 'Neoplasm Recurrence, Local', 'Parathyroid Hormone', 'Parathyroid Neoplasms', 'Postoperative Complications', 'Recurrent Laryngeal Nerve Injuries', 'Reoperation', 'Retrospective Studies', 'Treatmen... | 19,958,942 | [['C04.557.470.035'], ['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.888.852.544'], ['C19.642.355'], ['M01.060.116.630'], ['C04.697.655', 'C23.550.727.655'], ['D06.472.699.590', 'D12.644.548.587'], ['C04.588.322.525', 'C04.588.443.680', 'C19.344.525', 'C19.... | ['Diseases [C]', 'Named Groups [M]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Hyperparathyroidism in elderly osteopenic women. | Raised levels of parathyroid hormones (PTH) predispose to osteoporotic fracture particularly in the elderly. The true prevalence of primary or secondary hyperparathyroidism is unknown, as PTH evaluation is not performed as a screening test in the elderly. We report raised PTH levels in 27 of 190 (14.2%) community livin... | ['Aged', 'Calcium, Dietary', 'Dietary Supplements', 'England', 'Female', 'Humans', 'Hyperparathyroidism', 'Middle Aged', 'Osteoporosis, Postmenopausal', 'Parathyroid Hormone', 'Vitamin D'] | 12,468,132 | [['M01.060.116.100'], ['D01.146.395'], ['G07.203.300.456', 'J02.500.456'], ['Z01.542.363.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C19.642.355'], ['M01.060.116.630'], ['C05.116.198.579.610', 'C18.452.104.579.610'], ['D06.472.699.590', 'D12.644.548.587'], ['D04.210.500.812.768']] | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Geographicals [Z]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 |
[The enzyme-linked immunosorbent assay technic in syphilis serology (report on experiences)]. | A serological study with an enzyme-linked immunosorbent assay using the axial filament of Treponema phagedenis biotype Reiter as antigen was performed on 1899 sera to evaluate the sensitivity and specificity. The sensitivity as compared with the fluorescent treponemal antibody-absorption test (FTA-ABS) and the automate... | ['Automation', 'Chromatography, High Pressure Liquid', 'Enzyme-Linked Immunosorbent Assay', 'Flagella', 'Humans', 'Immunoenzyme Techniques', 'Immunoglobulin G', 'Immunoglobulin M', 'Syphilis Serodiagnosis', 'Treponema pallidum'] | 6,375,144 | [['J01.897.104'], ['E05.196.181.400.300'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['A11.284.180.290'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.478.566.350', 'E05.478.583.400', 'E05.601.470.350'], ['D12.776.124.486.485.114.619.3... | ['Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Organization and number of orexinergic neurons in the hypothalamus of two species of Cetartiodactyla: a comparison of giraffe (Giraffa camelopardalis) and harbour porpoise (Phocoena phocoena). | The present study describes the organization of the orexinergic (hypocretinergic) neurons in the hypothalamus of the giraffe and harbour porpoise--two members of the mammalian Order Cetartiodactyla which is comprised of the even-toed ungulates and the cetaceans as they share a monophyletic ancestry. Diencephalons from ... | ['Animals', 'Artiodactyla', 'Cell Size', 'Hypothalamus', 'Immunohistochemistry', 'Intracellular Signaling Peptides and Proteins', 'Male', 'Neurons', 'Neuropeptides', 'Orexins', 'Phocoena', 'Phylogeny', 'Ruminants', 'Species Specificity', 'Stereotaxic Techniques', 'Subthalamus', 'Visual Pathways'] | 22,683,547 | [['B01.050'], ['B01.050.150.900.649.313.500'], ['G04.325'], ['A08.186.211.180.497', 'A08.186.211.200.317.357'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512', 'H01.158.201.344.512', 'H01.158.201.486.512', 'H01.181.122.573.51... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Information Science [L]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Treatment of feline giardiasis during an outbreak of diarrhoea in a cattery: potential effects on faecal Escherichia coli resistance patterns. | OBJECTIVES: An outbreak of diarrhoea involving 16 cats at a cattery in Norway was investigated. Treatment and control of the outbreak were the primary objectives, but the effects of treatment on the antimicrobial resistance profiles of Escherichia coli isolated from faeces were also investigated.METHODS: Faecal samples... | ['Animals', 'Anti-Bacterial Agents', 'Antiprotozoal Agents', 'Cat Diseases', 'Cats', 'Diarrhea', 'Disease Outbreaks', 'Drug Resistance, Bacterial', 'Escherichia coli', 'Escherichia coli Infections', 'Feces', 'Female', 'Fenbendazole', 'Giardiasis', 'Microbial Sensitivity Tests', 'Microbiota'] | 26,071,424 | [['B01.050'], ['D27.505.954.122.085'], ['D27.505.954.122.250.100'], ['C22.180'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['C23.888.821.214'], ['N06.850.290'], ['G06.099.225', 'G06.225.347', 'G07.690.773.984.269.347'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['C01.150.252.400.310.330'], ['A12.45... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Immobilization of Irpex lacteus to liquid-core alginate beads and their application to degradation of pollutants. | White rot fungi (WRF) are applicable to biodegradation of recalcitrant pollutants. However, excessive biomass growth typical for WRF cultivation can hinder their large scale applications. Therefore, immobilization of Irpex lacteus to liquid-core alginate beads restricting excessive mycelium growth and simultaneously ke... | ['Alginates', 'Biodegradation, Environmental', 'Cells, Immobilized', 'Coloring Agents', 'Glucuronic Acid', 'Hexuronic Acids', 'Mycelium', 'Polyporales', 'Water Pollutants, Chemical'] | 28,213,748 | [['D09.698.068'], ['N06.230.080.600.500', 'N06.850.460.375.500'], ['A11.270'], ['D27.720.233'], ['D02.241.081.844.915.162.249', 'D02.241.152.811.162.500', 'D02.241.511.902.915.162.500', 'D09.811.922.162.500'], ['D02.241.081.844.915.400', 'D02.241.152.811.400', 'D02.241.511.902.915.400', 'D09.811.922.400'], ['A19.687'],... | ['Chemicals and Drugs [D]', 'Health Care [N]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Evaluation of Quality of Life, Functioning, Disability, and Work/School Productivity Following Treatment with an Extended-Release Hydrocodone Tablet Formulated with Abuse-Deterrence Technology: A 12-month Open-label Study in Patients with Chronic Pain. | BACKGROUND: This phase 3 study evaluated quality of life, functioning, and productivity after treatment with extended-release (ER) hydrocodone formulated with CIMA® Abuse-Deterrence Technology platform.METHODS: Patients with chronic pain were rolled over from a 12-week placebo-controlled hydrocodone ER study or were ne... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Analgesics, Opioid', 'Chronic Pain', 'Delayed-Action Preparations', 'Disability Evaluation', 'Drug Compounding', 'Educational Status', 'Efficiency', 'Female', 'Humans', 'Hydrocodone', 'Male', 'Middle Aged', 'Opioid-Related Disorders', 'Pain Measurement', 'Quality of... | 26,857,424 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.696.277.600.500', 'D27.505.696.663.850.014.760.500', 'D27.505.954.427.040.550.500', 'D27.505.954.427.210.600.500'], ['C23.888.592.612.274'], ['D26.255.210', 'E02.319.300.253'], ['E01.370.400'], ['E05.916.270'], ['N01.824.196'], [... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Challenges to "Classic" Esophageal Candidiasis: Looks Are Usually Deceiving. | Objectives: We undertook the first case control study of histologically confirmed esophageal candidiasis (EC).Methods: A computer search from July 2012 through February 2015 identified 1,011 esophageal specimens, including 40 cases of EC and 20 controls.Results: The EC incidence was 5.2%; it was associated with immunos... | ['Adult', 'Aged', 'Aged, 80 and over', 'Candidiasis', 'Case-Control Studies', 'Esophagitis', 'Female', 'Humans', 'Incidence', 'Male', 'Middle Aged', 'Risk Factors', 'Staining and Labeling', 'Young Adult'] | 28,158,394 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C01.150.703.160'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['C06.405.117.620', 'C06.405.205.663'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A novel copper(I) complex induces ER-stress-mediated apoptosis and sensitizes B-acute lymphoblastic leukemia cells to chemotherapeutic agents. | A phosphine copper(I) complex [Cu(thp)4][PF6] (CP) was recently identified as an efficient in vitro antitumor agent. In this study, we evaluated the antiproliferative activity of CP in leukemia cell lines finding a significant efficacy, especially against SEM and RS4;11 cells. Immunoblot analysis showed the activation ... | ['Apoptosis', 'Cations, Monovalent', 'Cell Line, Tumor', 'Coordination Complexes', 'Copper', 'Drug Delivery Systems', 'Endoplasmic Reticulum', 'Endoplasmic Reticulum Stress', 'Humans', 'Precursor Cell Lymphoblastic Leukemia-Lymphoma'] | 24,980,813 | [['G04.146.954.035'], ['D01.248.497.300.459'], ['A11.251.210.190', 'A11.251.860.180'], ['D01.234', 'D02.257'], ['D01.268.556.195', 'D01.268.956.170', 'D01.552.544.195'], ['E02.319.300'], ['A11.284.430.214.190.875.248'], ['G04.434'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.337.428.600', 'C15.604.515.5... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Apparent diffusion coefficient and enhancement patterns in MR imaging as markers of severe or moderate ileum inflammation in Crohn's disease. | BACKGROUND AND PURPOSE: magnetic resonance enterography has been increasingly used for the diagnosis and follow-up of Crohn's disease (CD). The purpose of the study was to compare the apparent diffusion coefficient (ADC) with wall enhancement for the differentiation of severe, moderate or no inflammation activity in th... | ['Adult', 'Area Under Curve', 'Case-Control Studies', 'Crohn Disease', 'Diagnosis, Differential', 'Diffusion Magnetic Resonance Imaging', 'Endoscopy, Gastrointestinal', 'Female', 'Humans', 'Ileal Diseases', 'Ileum', 'Image Enhancement', 'Male', 'Observer Variation', 'Prospective Studies', 'ROC Curve'] | 30,284,909 | [['M01.060.116'], ['E05.318.740.200', 'G03.787.101', 'G07.690.725.064', 'N06.850.520.830.200'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['C06.405.205.731.500', 'C06.405.469.432.500'], ['E01.171'], ['E01.370.350.825.500.150'], ['E01.370.372.250.250', 'E01.370.388.250.250.250', 'E04... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Information Science [L]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Comparative analysis of normal and malignant CD5+ B lymphocytes. | The T-cell related CD5 molecule is expressed by the major B cell population which forms primary follicles in fetal lymph nodes and spleen and circulates in cord blood but decreases to a numerically minor proportion (5-10% of all B cells) in adults [1, 3-5, 8, 9, 12, 14, 16]. The CD5 molecule is also expressed by the mo... | ['Antigens, Differentiation, B-Lymphocyte', 'B-Lymphocytes', 'Cell Cycle', 'Cytoskeleton', 'Fetal Blood', 'Humans', 'Leukemia, Lymphocytic, Chronic, B-Cell', 'Phenotype'] | 3,265,499 | [['D23.050.301.264.051', 'D23.101.100.150'], ['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['G04.144'], ['A11.284.430.214.190.750'], ['A12.207.152.200', 'A15.145.300', 'A16.378.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.33... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mutations of the Kirsten-ras proto-oncogene in human preleukaemia. | The myelodysplastic syndrome (MDS) or preleukaemia is a haematological disorder characterized by low blood counts, bone marrow cells of abnormal appearance and progression to acute leukaemia in as many as 30% of patients. The distinctive preleukaemic and leukaemic phases of this disease make it an attractive model for ... | ['Adult', 'Alleles', 'Base Sequence', 'Cell Transformation, Neoplastic', 'Codon', 'Genes, ras', 'Humans', 'Male', 'Mutation', 'Preleukemia', 'Proto-Oncogenes', 'Tumor Stem Cell Assay'] | 3,313,061 | [['M01.060.116'], ['G05.360.340.024.340.030'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['C04.697.098.500', 'C23.550.727.098.500'], ['D13.444.735.544.355', 'G05.360.335.355', 'G05.360.340.024.340.137.190'], ['G05.360.340.024.340.375.500.791.550'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G05... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Uncoupling of the DNA breaking and rejoining steps of Escherichia coli type I DNA topoisomerase. Demonstration of an active covalent protein-DNA complex. | DNA topoisomerases have been shown to cleave DNA phosphodiester bond and simultaneously become linked to the DNA at the cleavage site via a phosphotyrosine linkage (Tse, Y.-C., Kirkegaard, K., and Wang, J. C. (1980) J. Biol. Chem. 255, 5560-5565). For prokaryotic DNA topoisomerases, this is observed only when denaturan... | ['DNA', 'DNA Topoisomerases, Type I', 'Electrophoresis, Agar Gel', 'Escherichia coli', 'Kinetics', 'Oligodeoxyribonucleotides', 'Phosphorus Radioisotopes', 'Protein Binding'] | 3,015,947 | [['D13.444.308'], ['D08.811.399.403.483', 'D12.776.157.687.375', 'D12.776.660.720.375'], ['E05.196.401.153', 'E05.301.300.100'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['G01.374.661', 'G02.111.490'], ['D13.695.578.424.450'], ['D01.268.666.500.604', 'D01.496.669.604', 'D01.496.749.658'], ['G02.111.679',... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The effect of phosphatases SHP-1 and SHIP-1 on signaling by the ITIM- and ITAM-containing Fcgamma receptors FcgammaRIIB and FcgammaRIIA. | Inositol and tyrosine phosphatases have been implicated in inhibitory signaling by an Fc receptor for immunoglobulin G, FcgammaRIIB, in B cells, mast cells, and monocytes. Here, we propose a role for the Src homology 2 (SH2)-containing tyrosine phosphatase-1 (SHP-1) in FcgammaRIIB-mediated inhibition of FcgammaR signal... | ['Amino Acid Motifs', 'Animals', 'Antigens, CD', 'COS Cells', 'Cells, Cultured', 'Enzyme Precursors', 'Humans', 'Intracellular Signaling Peptides and Proteins', 'Monocytes', 'Phagocytosis', 'Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases', 'Phosphoric Monoester Hydrolases', 'Phosphorylation', 'Protein Phosphat... | 12,773,515 | [['G02.111.570.820.709.275.500', 'G02.111.570.820.709.600.500'], ['B01.050'], ['D23.050.301.264.035', 'D23.101.100.110'], ['A11.251.210.172.500', 'A11.329.228.220'], ['A11.251'], ['D08.622', 'D12.776.811.243'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.360', 'D12.776.476'], ['A11.118.637.555.652', 'A11... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Tracheal extubation of deeply anesthetized pediatric patients: a comparison of isoflurane and sevoflurane. | UNLABELLED: We studied the emergence characteristics of unpremedicated children tracheally extubated while deeply anesthetized ("deep extubation") with isoflurane or sevoflurane. Forty children were assigned to one of two groups, Group I or Group S. At the end of the operation, Group I patients were extubated while bre... | ['Adolescent', 'Anesthetics, Inhalation', 'Arousal', 'Child', 'Child, Preschool', 'Delirium', 'Humans', 'Infant', 'Intubation, Intratracheal', 'Isoflurane', 'Methyl Ethers', 'Sevoflurane', 'Time Factors', 'Vomiting'] | 10,195,515 | [['M01.060.057'], ['D27.505.696.277.100.035.060', 'D27.505.954.427.210.100.035.060'], ['F02.830.104', 'G11.561.035'], ['M01.060.406'], ['M01.060.406.448'], ['C10.597.606.337.500', 'C23.888.592.604.339.500', 'F01.700.250.500', 'F03.615.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['E02.041.50... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Quantitative single cell methods that identify cytokine and chemokine expression in dendritic cells. | Two techniques based upon flow cytometry (FCM) and in situ image analysis were developed for quantification of intracellular cytokine and chemokine protein expression at the single cell level in dendritic cells (DCs). The qualitative and quantitative differences between the two methods were evaluated. In vitro differen... | ['Chemokines', 'Cytokines', 'Dendritic Cells', 'Flow Cytometry', 'Humans', 'Immunologic Techniques', 'Sensitivity and Specificity'] | 11,226,478 | [['D12.644.276.374.200', 'D12.776.467.374.200', 'D23.125.300', 'D23.469.200', 'D23.529.374.200'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['A11.066.270', 'A11.436.270', 'A15.382.066.270', 'A15.382.670.260'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.50... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Adenosine induces apoptosis in the human gastric cancer cells via an intrinsic pathway relevant to activation of AMP-activated protein kinase. | Extracellular adenosine significantly reduced cell viability in a dose (0.1-20mM)- and treatment time (24-72h)-dependent manner in GT3-TKB cells, a human gastric cancer cell line. Nuclei of cells were reactive to Hoechst 33342, a marker of apoptosis, and an anti-single-stranded DNA. Adenosine-induced GT3-TKB cell death... | ['Adenine', 'Adenosine', 'Adenylate Kinase', 'Aminoimidazole Carboxamide', 'Apoptosis', 'Caspase Inhibitors', 'Dipyridamole', 'Drug Interactions', 'Enzyme Activation', 'Humans', 'Membrane Potentials', 'Mitochondria', 'Receptors, Purinergic P1', 'Ribonucleotides', 'Signal Transduction', 'Stomach Neoplasms', 'Tumor Cells... | 15,130,776 | [['D03.633.100.759.138'], ['D03.633.100.759.590.138', 'D13.570.583.138', 'D13.570.800.096'], ['D08.811.913.696.650.025'], ['D03.383.129.308.030'], ['G04.146.954.035'], ['D27.505.519.389.745.325.500'], ['D03.383.742.175'], ['G07.690.773.968'], ['G02.111.263', 'G03.328'], ['B01.050.150.900.649.313.988.400.112.400.400'], ... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effect of etofylline clofibrate on experimental thrombosis and platelet function. | 1-(Theophyllin-7yl)-ethyl-2-[2-(p-chlorophenoxy)-2-methylpropionate] (etofylline clofibrate, ML 1024, Duolip) was shown to be a potent inhibitor of experimental thrombus formation in the microvasculature of the hamster cheek pouch and of platelet aggregation and adhesiveness in the cynomolgus monkey. Inhibitory effect ... | ['Animals', 'Blood Platelets', 'Clofibrate', 'Cricetinae', 'Female', 'Hypolipidemic Agents', 'In Vitro Techniques', 'Macaca fascicularis', 'Male', 'Platelet Adhesiveness', 'Platelet Aggregation', 'Thrombosis'] | 7,194,057 | [['B01.050'], ['A11.118.188', 'A15.145.229.188'], ['D02.241.081.114.968.500.500.195', 'D02.355.726.305.500.195', 'D02.455.426.559.389.657.654.305.500.195'], ['B01.050.150.900.649.313.992.635.075.250'], ['D27.505.519.186.071', 'D27.505.954.557.500'], ['E05.481'], ['B01.050.150.900.649.313.988.400.112.199.120.510.520'], ... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effect of hypothermia on beta 1-adrenoceptor-mediated relaxation of pig bronchus. | The relaxant potencies of (+/-)-isoprenaline and of (-)-noradrenaline (NA) in the pig isolated bronchus were increased 5.4 and 3.1 fold respectively by lowering the organ bath temperature from 37 degrees C to 27 degrees C, whereas the potencies of the non-catecholamine beta-adrenoceptor agonists fenoterol and orciprena... | ['Adrenergic beta-Agonists', 'Airway Resistance', 'Animals', 'Bronchi', 'Catechol O-Methyltransferase Inhibitors', 'Cold Temperature', 'Drug Interactions', 'Hydrocortisone', 'In Vitro Techniques', 'Propiophenones', 'Swine'] | 6,152,829 | [['D27.505.519.625.050.100.200', 'D27.505.696.577.050.100.200'], ['E01.370.386.700.050', 'G09.772.060'], ['B01.050'], ['A04.411.125'], ['D27.505.519.389.237', 'D27.505.954.427.090.050.500'], ['G01.906.595.272', 'G16.500.275.063.725.710.300', 'G16.500.750.775.710.300', 'N06.230.300.100.725.154', 'N06.230.300.100.725.710... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Effects of inhalable particulate matter on blood coagulation. | BACKGROUND: Particulate matter (PM) exposure has been linked to increased risk of cardiovascular disease, possibly resulting from hypercoagulability and thrombosis. Lung and systemic inflammation resulting from PM inhalation may activate blood coagulation, but mechanisms for PM-related hypercoagulability are still larg... | ['Adult', 'Biomarkers', 'Blood Coagulation', 'C-Reactive Protein', 'Fibrin Fibrinogen Degradation Products', 'Humans', 'Inflammation', 'Inflammation Mediators', 'Inhalation Exposure', 'Italy', 'Male', 'Metallurgy', 'Middle Aged', 'Occupational Diseases', 'Occupational Exposure', 'Partial Thromboplastin Time', 'Particle... | 19,922,434 | [['M01.060.116'], ['D23.101'], ['G09.188.390.150'], ['D12.776.034.145', 'D12.776.124.050.120', 'D12.776.124.486.157'], ['D12.776.124.270.300', 'D12.776.811.300.290'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.470'], ['D23.469'], ['N06.850.460.350.112'], ['Z01.542.489'], ['J01.576.655.875.400'], ['M01.0... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]', 'Geographicals [Z]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
Comparison of a minimally invasive technique with open tension band wiring for displaced transverse patellar fractures. | BACKGROUND: Open reduction and internal fixation with tension band wire is the standard treatment for displaced transverse patellar fractures. Recently, some minimally invasive techniques have been proposed as possible alternative methods. This retrospective study compared a newly reported percutaneous osteosynthesis w... | ['Adult', 'Aged', 'Bone Wires', 'Female', 'Fracture Fixation, Internal', 'Humans', 'Male', 'Middle Aged', 'Minimally Invasive Surgical Procedures', 'Patella', 'Reoperation', 'Retrospective Studies'] | 21,783,097 | [['M01.060.116'], ['M01.060.116.100'], ['E07.695.370.468', 'E07.858.442.660.460.468', 'E07.858.690.725.460.468'], ['E04.555.300.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E04.502'], ['A02.835.232.043.650.624', 'A02.835.232.730.500'], ['E04.690'], ['E05.318.372.500.500.500', 'E05.318.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A Novel Antiviral Target Structure Involved in the RNA Binding, Dimerization, and Nuclear Export Functions of the Influenza A Virus Nucleoprotein. | Developing antiviral therapies for influenza A virus (IAV) infection is an ongoing process because of the rapid rate of antigenic mutation and the emergence of drug-resistant viruses. The ideal strategy is to develop drugs that target well-conserved, functionally restricted, and unique surface structures without affect... | ['Active Transport, Cell Nucleus', 'Animals', 'Antiviral Agents', 'Humans', 'Influenza A virus', 'Mice', 'Nucleocapsid Proteins', 'Protein Multimerization', 'RNA, Viral', 'RNA-Binding Proteins', 'Structure-Activity Relationship', 'Viral Core Proteins'] | 26,222,066 | [['G03.143.310.100', 'G03.143.700.100'], ['B01.050'], ['D27.505.954.122.388'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B04.820.480.968.405.400'], ['B01.050.150.900.649.313.992.635.505.500'], ['D12.776.964.970.600'], ['G02.111.694'], ['D13.444.735.828'], ['D12.776.157.725', 'D12.776.664.962'], ['G02.111.830',... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
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