Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Early Childhood Adversity and its Associations With Anxiety, Depression, and Distress in Women With Breast Cancer. | BACKGROUND: Certain vulnerability factors have been found to place patients at risk for depression and anxiety, especially within the context of medical illness.OBJECTIVES: We sought to describe the relationships among early childhood adversity (ECA) and anxiety, depression and distress in patients with breast cancer.M... | ['Adult', 'Aged', 'Aged, 80 and over', 'Anxiety Disorders', 'Breast Neoplasms', 'Child', 'Child Abuse', 'Comorbidity', 'Depressive Disorder', 'Female', 'Humans', 'Middle Aged', 'Risk Factors', 'Stress, Psychological', 'Surveys and Questionnaires'] | 26,876,888 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['F03.080'], ['C04.588.180', 'C17.800.090.500'], ['M01.060.406'], ['I01.198.240.856.350.250', 'I01.880.735.900.350.250'], ['N05.715.350.225', 'N06.850.490.687'], ['F03.600.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.3... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Impact of endoscopic sinus surgery on global health perception: an outcomes study. | The Medical Outcome Study Short-Form 36-item Health Survey (SF-36) was used to prospectively assess outcomes after endoscopic sinus surgery. Our study found that chronic rhinosinusitis has a significant adverse impact on patient-perceived functional status and quality of life. Endoscopic sinus surgery resulted in stati... | ['Adolescent', 'Adult', 'Child', 'Chronic Disease', 'Endoscopy', 'Female', 'Humans', 'Male', 'Middle Aged', 'Otorhinolaryngologic Surgical Procedures', 'Outcome Assessment, Health Care', 'Prospective Studies', 'Quality of Life', 'Rhinitis', 'Sinusitis'] | 9,807,074 | [['M01.060.057'], ['M01.060.116'], ['M01.060.406'], ['C23.550.291.500'], ['E01.370.388.250', 'E04.502.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E04.580'], ['H01.770.644.145.431', 'N04.761.559.590', 'N05.715.360.575.575'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 |
Presynaptic A-current based on heteromultimeric K+ channels detected in vivo. | A wide variety of voltage-gated K+ channels are involved in the regulation of neuronal excitability and synaptic transmission. Their heterogeneity arises in part from the large number of genes encoding different K+ channel subunits (reviewed in ref. 1). In addition, heterologous expression studies indicate that assembl... | ['Amino Acid Sequence', 'Animals', 'Brain', 'Cell Line', 'Chromatography, Agarose', 'Electrophysiology', 'Immunohistochemistry', 'Membrane Proteins', 'Molecular Sequence Data', 'Potassium Channels', 'Precipitin Tests', 'Rats', 'Synapses'] | 8,361,540 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['A08.186.211'], ['A11.251.210'], ['E05.196.181.400.250.200'], ['H01.158.344.528', 'H01.158.782.236'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512', 'H01.158.201.344... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
A model for the circadian rhythm of cyanobacteria that maintains oscillation without gene expression. | An intriguing property of the cyanobacterial circadian clock is that endogenous rhythm persists when protein abundances are kept constant either in the presence of translation and transcription inhibitors or in the constant dark condition. Here we propose a regulatory mechanism of KaiC phosphorylation for the generatio... | ['Bacterial Proteins', 'Circadian Rhythm', 'Circadian Rhythm Signaling Peptides and Proteins', 'Cyanobacteria', 'Darkness', 'Gene Expression Regulation, Bacterial', 'Light', 'Models, Biological', 'Phosphorylation'] | 16,798,799 | [['D12.776.097'], ['G07.180.562.190'], ['D12.644.360.138', 'D12.776.476.156'], ['B03.280', 'B03.440.475.100'], ['G01.590.540.233'], ['G05.308.300'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['E05.599.395'], ['G02.111.665', 'G02.607.780', 'G03.796']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension. | MAP kinase (MAPK) cascades are composed of a MAPK, MAPK kinase (MAPKK), and a MAPKK kinase (MAPKKK). Despite the existence of numerous components and ample opportunities for crosstalk, most MAPKs are specifically and distinctly activated. We investigated the basis for specific activation of the JNK subgroup of MAPKs. T... | ['Animals', 'Binding, Competitive', 'COS Cells', 'Calcium-Calmodulin-Dependent Protein Kinases', 'Enzyme Activation', 'Humans', 'JNK Mitogen-Activated Protein Kinases', 'MAP Kinase Kinase 4', 'MAP Kinase Kinase Kinase 1', 'Mitogen-Activated Protein Kinase 1', 'Mitogen-Activated Protein Kinase Kinases', 'Mitogen-Activat... | 9,808,624 | [['B01.050'], ['E05.196.080', 'G02.111.084', 'G02.111.570.120.309'], ['A11.251.210.172.500', 'A11.329.228.220'], ['D08.811.913.696.620.682.700.125', 'D12.644.360.100', 'D12.776.476.100'], ['G02.111.263', 'G03.328'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.913.696.620.682.700.567.374', 'D12.644.360.45... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mixed lymphocyte reactivity in chimpanzees. II. Family studies and identification of D locus antigens. | A large number of related chimpanzees were tested in mixed lymphocyte cultures against each other. Several similarities among the D locus products coded for by different ChLA haplotypes were observed. Six animals were found to be homozygous for D locus antigens and two of these animals carried the same D specificity. H... | ['Animals', 'Chromosome Mapping', 'Epitopes', 'Female', 'Genetic Linkage', 'Genotype', 'Haploidy', 'Histocompatibility Antigens', 'Homozygote', 'Lymphocyte Culture Test, Mixed', 'Male', 'Pan troglodytes'] | 6,165,095 | [['B01.050'], ['E05.393.183'], ['D23.050.550'], ['G05.348'], ['G05.380'], ['G05.700.456'], ['D23.050.301.500', 'D23.050.705.552'], ['G05.380.554'], ['E01.370.225.812.385.475', 'E05.200.812.385.475', 'E05.478.594.385.429'], ['B01.050.150.900.649.313.988.400.112.400.620']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Calmodulin-binding protein (55K + 17K) of sea urchin eggs has a Ca2+- and calmodulin-dependent phosphoprotein phosphatase activity. | A calmodulin-binding protein from sea urchin eggs consisting of two subunits (55 and 17K-daltons) was identified as a Ca2+-dependent phosphoprotein phosphatase similar to calcineurin in mammalian brain and to phosphatase 2B in skeletal muscle. Peptide mappings showed that the 55K subunit was different from 61K subunit ... | ['Animals', 'Calcium', 'Calmodulin', 'Calmodulin-Binding Proteins', 'Carrier Proteins', 'Intracellular Signaling Peptides and Proteins', 'Molecular Weight', 'Ovum', 'Phosphoprotein Phosphatases', 'Proteins', 'Sea Urchins'] | 3,011,771 | [['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D12.644.360.372.249', 'D12.776.157.125.412.249', 'D12.776.476.387.249'], ['D12.776.157.142'], ['D12.776.157'], ['D12.644.360', 'D12.776.476'], ['G02.494'], ['A05.360.490.690', 'A11.497.497', 'A16.690'], ['D08.811.277.352.650.625'], ['D12.776'], ['B0... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Women, incarceration and HIV: a systematic review of HIV treatment access, continuity of care and health outcomes across incarceration trajectories. | OBJECTIVE: The aim of this study was to systematically review the literature on gendered implications of incarceration for HIV outcomes and engagement in care for women living with HIV (WLWH).DESIGN: We systematically searched seven bibliographic databases, for peer-reviewed English-language studies, published between ... | ['Continuity of Patient Care', 'Female', 'Global Health', 'HIV Infections', 'Humans', 'Male', 'Medication Adherence', 'Prisoners', 'Prisons', 'Treatment Outcome', 'Viral Load'] | 30,289,811 | [['E02.760.169', 'N02.421.585.169', 'N04.590.233.727.210'], ['H02.403.371', 'N01.400.337'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.100.150.750.500.600.500', 'F01.145.488.887.500.60... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Technology, Industry, and Agriculture [J]'... | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 |
Cryptorchidism: the surgical implications of non-union of the epididymis and testis. | A boy with a non-palpable undescended testis was found to have a 7.5 cm. separation between the detached epididymis and testis. This anomaly of non-union of the epididymis and testis emphasizes the need for careful exploration of the non-palpable undescended testis. | ['Cryptorchidism', 'Epididymis', 'Humans', 'Infant', 'Male', 'Testis'] | 6,106,722 | [['C12.294.829.258', 'C12.706.258', 'C16.131.939.258', 'C19.391.829.258'], ['A05.360.444.371'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['A05.360.444.849', 'A05.360.576.782', 'A06.300.312.782']] | ['Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Named Groups [M]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Immunoglobulin gene rearrangement in the peripheral blood and bone marrow of patients with lymphomas of the mucosa-associated lymphoid tissues. | The theory of 'homing' mechanism has been proposed to explain the association of malignant lymphoma involving multiple sites of mucosa-associated lymphoid tissue (MALT). DNA rearrangement in the peripheral blood and bone marrow specimens of 20 patients with MALT lymphoma were studied utilizing JH and C beta gene probes... | ['Adult', 'Bone Marrow', 'DNA Probes', 'DNA, Neoplasm', 'Gene Rearrangement', 'Genes, Immunoglobulin', 'Humans', 'Lymphoid Tissue', 'Lymphoma, Non-Hodgkin', 'Mucous Membrane'] | 2,117,323 | [['M01.060.116'], ['A15.382.216'], ['D13.444.600.223', 'D27.505.259.750.600.223', 'D27.720.470.530.600.223'], ['D13.444.308.425'], ['G05.344'], ['G05.360.340.024.340.335', 'G12.500.299'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A10.549', 'A15.382.520.604'], ['C04.557.386.480', 'C15.604.515.569.480', 'C20.683... | ['Named Groups [M]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Sarmiento functional treatment of humeral shaft fractures. Results and experiences]. | Functional treatment according to Sarmiento was applied to 20 cases of humerus shaft fracture, in the course of three years. All fractures healed with good functional result. The approach proved to be effective. Functional treatment, using Brace, was indicated even for fractures in the proximal or distal third of the h... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Braces', 'Female', 'Follow-Up Studies', 'Humans', 'Humeral Fractures', 'Male', 'Middle Aged', 'Radiography', 'Wound Healing'] | 3,425,021 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E07.858.442.743.319'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C26.088.390', 'C26.404.500'], ['M01.060.116.630'], ['E01.370.350.700'], ... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Criminal burning. | We report a study of 40 burnt bodies on which an autopsy was carried out at the Institut de M?decine L?gale in Lyon (28 men/12 women, average age = 41 years, minimum age = 3 years, maximum age = 86 years). Criminal deaths (31%) represented the second cause of death after accidents (52%), and before suicide (16%). Crimi... | ['Accidents', 'Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Burns', 'Carboxyhemoglobin', 'Cause of Death', 'Child', 'Child, Preschool', 'Female', 'Forensic Medicine', 'France', 'Homicide', 'Humans', 'Male', 'Middle Aged', 'Retrospective Studies', 'Sex Distribution', 'Suicide', 'Wounds, Nonpenetrating', 'Wounds, ... | 15,982,840 | [['N06.850.135'], ['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C26.200'], ['D12.776.124.400.141', 'D12.776.422.316.762.149'], ['E05.318.308.985.550.250', 'N01.224.935.698.100', 'N06.850.505.400.975.550.250', 'N06.850.520.308.985.550.250'], ['M01.060.406'], ['M01.060.406.448'], ['H02... | ['Health Care [N]', 'Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]', 'Organisms [B]', 'Psychiatry and Psychology [... | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
In vivo modification of native carrier protein domains. | Carrier proteins are central to the biosynthesis of primary and secondary metabolites in all organisms. Here we describe metabolic labeling and manipulation of native acyl carrier proteins in both type I and II fatty acid synthases. By utilizing natural promiscuity in the CoA biosynthetic pathway in combination with sy... | ['Acyl Carrier Protein', 'Affinity Labels', 'Amino Acid Sequence', 'Bacteria', 'Bacterial Proteins', 'Base Sequence', 'Cell Line, Tumor', 'Cell Survival', 'Fatty Acids', 'Gene Knockdown Techniques', 'Humans', 'Molecular Sequence Data', 'Protein Structure, Tertiary', 'Protein Transport', 'Proteomics', 'Sequence Analysis... | 19,308,927 | [['D12.776.157.050'], ['D27.720.470.410.080'], ['G02.111.570.060', 'L01.453.245.667.060'], ['B03'], ['D12.776.097'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.346'], ['D10.251'], ['E05.393.335.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.45... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Agglutinating mouse IgG3 compares favourably with IgMs in typing of the blood group B antigen: Functionality and stability studies. | Mouse immunoglobulins M (IgMs) that recognize human blood group antigens induce haemagglutination and are used worldwide for diagnostic blood typing. Contrary to the current belief that IgGs are too small to simultaneously bind antigens on two different erythrocytes, we obtained agglutinating mouse IgG3 that recognized... | ['ABO Blood-Group System', 'Animals', 'Blood Grouping and Crossmatching', 'Hemagglutination', 'Humans', 'Immunoglobulin G', 'Immunoglobulin M', 'Mice'] | 27,484,487 | [['D23.050.301.290.031', 'D23.050.705.230.031'], ['B01.050'], ['E01.370.225.625.120', 'E01.370.225.812.385.120', 'E05.200.625.120', 'E05.200.812.385.120', 'E05.478.594.385.120'], ['G02.111.026.500', 'G12.122.100.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.124.486.485.114.619.393', 'D12.776.124.790... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The role of outcomes data in health-care resource allocation. | The purpose of this article was to provide information about the importance of outcome measures in the health-care resource allocation scenario. The increasing focus on outcome measures as a more suitable way to demonstrate the value of services is discussed. Health-care trends toward the use of data from patient outco... | ['Correction of Hearing Impairment', 'Evidence-Based Medicine', 'Health Care Rationing', 'Health Care Reform', 'Hearing Aids', 'Humans', 'Outcome Assessment, Health Care', 'Patient Satisfaction', 'Quality of Life', 'Treatment Outcome', 'United States', 'World Health Organization'] | 10,981,598 | [['E02.760.169.063.500.200', 'E02.831.200', 'H02.403.680.600.500', 'N02.421.784.377'], ['H02.249.750', 'H02.403.200.400'], ['I01.261.750.500', 'N03.349.270', 'N05.300.430.375'], ['I01.655.500.608.400.285', 'I01.880.604.825.608.400.285', 'N03.349.285', 'N03.623.500.608.428.285', 'N04.590.374.285', 'N05.300.380'], ['E07.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Humanities [K]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 |
The human insulin-like growth factor II leader 1 contains an internal ribosomal entry site. | Insulin-like growth factor II is a small peptide growth hormone, encoded by four mRNAs with unique 5' untranslated regions and identical coding regions. The 5' untranslated region transcribed from promoter 1 is 598 nt (leader 1). The properties of this leader 1 suggest a strong regulation of translation; the high G + C... | ['Base Sequence', 'Binding Sites', 'Gene Expression', 'HeLa Cells', 'Humans', 'Insulin-Like Growth Factor II', 'Molecular Sequence Data', 'Plasmids', 'Protein Biosynthesis', 'RNA Caps', 'Ribosomes', 'Transfection'] | 8,547,330 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G02.111.570.120'], ['G05.297'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.937.420', 'D12.776.124.862.425', 'D12.776.467.937.420', 'D23.529.937.420'], ['L01.453.245.667'], ['G... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Production of limit size nanoliposomal systems with potential utility as ultra-small drug delivery agents. | Previous studies from this group have shown that limit size lipid-based systems--defined as the smallest achievable aggregates compatible with the packing properties of their molecular constituents--can be efficiently produced using rapid microfluidic mixing technique. In this work, it is shown that similar procedures ... | ['Animals', 'Drug Carriers', 'Drug Delivery Systems', 'Lipids', 'Liposomes', 'Mice', 'Nanoparticles', 'Particle Size', 'Surface Properties'] | 25,856,305 | [['B01.050'], ['D26.255.260', 'E02.319.300.380'], ['E02.319.300'], ['D10'], ['D25.479.517', 'D26.255.260.517', 'J01.637.051.479.517', 'J01.637.087.500.517'], ['B01.050.150.900.649.313.992.635.505.500'], ['J01.637.512.600'], ['G02.712'], ['G02.860']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Two rheologically different gastric mucus secretions with different putative functions. | Previous work has shown the presence of different mucin gene products and glycosylated species in gastric mucus secretions, however, the functional relevance of these differences is unclear. This study aimed to investigate rheologically, differences in the gel behaviour within gastric mucus samples using a pig model. R... | ['Animals', 'Enzyme-Linked Immunosorbent Assay', 'Gastric Mucins', 'Gels', 'Glycoproteins', 'Humans', 'Lectins', 'Mucus', 'Peptide Fragments', 'Protein Binding', 'Rheology', 'Shear Strength', 'Swine', 'Viscosity'] | 15,374,617 | [['B01.050'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['D12.776.395.560.631.100'], ['D20.280.320', 'D26.255.165.320'], ['D09.400.430', 'D12.776.395'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.503'], ['A12.200.503'], ['D12.644... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
[Use of a mixed cell suspension obtained from the livers of different rats for cytological studies]. | The possibility of employing a mixed suspension of isolated liver cells from several rats for estimation of some quantitative characters commonly used in cytological investigations was studied. It is demonstrated that the disaggregation rate of liver in different animals varies slightly, and the mean values of the para... | ['Animals', 'Cell Separation', 'Liver', 'Mitosis', 'Rats'] | 941,267 | [['B01.050'], ['E01.370.225.500.363', 'E05.200.500.363', 'E05.242.363'], ['A03.620'], ['G04.144.220.220.781', 'G05.113.220.781'], ['B01.050.150.900.649.313.992.635.505.700']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Impact of Genetic Polymorphism in the â2-Receptor Gene on Risk of Severe Hypoglycemia in Patients With Type 1 Diabetes. | Context: Severe hypoglycemic events are unevenly distributed in people with type 1 diabetes, making a genetic influence probable. Of the common adrenoceptor â-2 receptor gene (ADRB2) polymorphisms, the Arg16 allele is associated with receptor downregulation and reduced agonist-mediated endogenous glucose production.Obj... | ['Adult', 'Aged', 'Diabetes Mellitus, Type 1', 'Female', 'Genetic Predisposition to Disease', 'Genotype', 'Humans', 'Hypoglycemia', 'Male', 'Middle Aged', 'Polymorphism, Genetic', 'Receptors, Adrenergic, beta-2', 'Retrospective Studies', 'Risk Factors', 'Severity of Illness Index'] | 29,757,443 | [['M01.060.116'], ['M01.060.116.100'], ['C18.452.394.750.124', 'C19.246.267', 'C20.111.327'], ['C23.550.291.687.500', 'G05.380.355'], ['G05.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C18.452.394.984'], ['M01.060.116.630'], ['G05.365.795'], ['D12.776.543.750.670.300.300.340.200', 'D12.776.543.750.695.150.... | ['Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Diverse clinical and laboratory manifestations of bilateral vestibulopathy. | OBJECTIVES/HYPOTHESIS: To identify the clinical and laboratory characteristics of bilateral vestibulopathy (BVP) on the video head impulse test (vHIT).STUDY DESIGN: Retrospective chart analysis.METHODS: During 23 months, 1,789 patients with dizziness underwent vHIT in our tertiary referral hospital. Of these patients, ... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Bilateral Vestibulopathy', 'Caloric Tests', 'Female', 'Head Impulse Test', 'Humans', 'Male', 'Middle Aged', 'Retrospective Studies'] | 26,972,747 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C09.218.568.900.442', 'C10.597.057', 'C23.888.592.057'], ['E01.370.382.900.150'], ['E01.370.382.900.640'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Longterm effects of prolonged maintenance and of very early intensification chemotherapy in AML: data from AMLCG. | In order to further improve the cure rate in AML we investigated the effect of more chemotherapy--in terms of its intensity and its duration--in 2 studies. In our 1981 study patients received TAD 1-2 courses for induction, 1 course for consolidation and randomly no further treatment or monthly myelosuppressive maintena... | ['Acute Disease', 'Adolescent', 'Adult', 'Age Factors', 'Aged', 'Antineoplastic Combined Chemotherapy Protocols', 'Cytarabine', 'Daunorubicin', 'Drug Administration Schedule', 'Humans', 'Leukemia, Myeloid', 'Middle Aged', 'Recurrence', 'Remission Induction', 'Thioguanine'] | 1,578,946 | [['C23.550.291.125'], ['M01.060.057'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['D03.383.742.680.245.453', 'D13.570.065.300', 'D13.570.685.245.453'], ['D02.455.426.559.847.562.050.200', 'D04.615.562.050.200', 'D09.408.051.0... | ['Diseases [C]', 'Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
An epidemiological survey of wild caught and domestic born rhesus monkeys (Macaca mulatta) for Anatrichosoma (Nematoda: Trichinellida). | A group of wild caught rhesus monkeys and their domestic born infants were examined for Anatrichosoma, a nematode that inhabits the nasal mucosa and subcutaneous tissue of the face, hands, and feet. The diagnosis was made using nasal swabs. Fifty-four percent of the wild caught animals reported positive ina survey take... | ['Animals', 'Animals, Wild', 'Female', 'India', 'Macaca', 'Macaca mulatta', 'Male', 'Nematode Infections', 'Trichuroidea'] | 7,343,773 | [['B01.050'], ['B01.050.050.300'], ['Z01.252.245.393'], ['B01.050.150.900.649.313.988.400.112.199.120.510'], ['B01.050.150.900.649.313.988.400.112.199.120.510.550'], ['C01.610.335.508'], ['B01.050.500.500.294.100.275.780']] | ['Organisms [B]', 'Geographicals [Z]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Outcomes in stage I testicular seminoma: a population-based study of 9193 patients. | BACKGROUND: Few studies have quantified temporal patterns of cause-specific mortality in contemporary cohorts of men with early-stage seminoma. Given that several management strategies can be applied in these patients, each resulting in excellent long-term survival, it is important to evaluate associated long-term sequ... | ['Adolescent', 'Adult', 'Aged', 'Cardiovascular Diseases', 'Humans', 'Male', 'Middle Aged', 'Neoplasm Staging', 'Neoplasms, Second Primary', 'Proportional Hazards Models', 'Risk Factors', 'SEER Program', 'Seminoma', 'Testicular Neoplasms', 'Treatment Outcome', 'United States', 'Young Adult'] | 23,633,409 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['C14'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.789.625'], ['C04.692'], ['E05.318.740.500.700', 'E05.318.740.600.700', 'E05.318.740.750.725', 'E05.318.740.998.825', 'E05.599.835.900', 'N05.715.360.750.530.650', 'N05.715.360.750... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Methods in laboratory investigation. Monoclonal antibodies to type IV collagen: probes for the study of structure and function of basement membranes. | Type IV collagen is one of the main constituents of basement membranes, yet it is unknown whether the structural framework at different sites is assembled from one unique type of molecule or whether different type IV collagen molecules exist. To study the composition, chemical identity, and organization of this protein... | ['Antibodies, Monoclonal', 'Antibody Specificity', 'Antibody-Producing Cells', 'Basement Membrane', 'Collagen', 'Humans', 'Hybrid Cells', 'Placenta'] | 6,682,465 | [['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['G12.100'], ['A11.063', 'A15.382.032'], ['A10.272.220', 'A10.615.179'], ['D05.750.078.280', 'D12.776.860.300.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.251.600'], ['A16.710']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Morphological and cytochemical findings in 150 cases of T-lineage acute lymphoblastic leukaemia in adults. German Multicentre ALL Study Group (GMALL). | We evaluated the morphological findings in 150 consecutive cases of T-lineage acute lymphocytic leukaemia (T-ALL). Cytochemistry including PAS staining and acid phosphatase reaction proved of limited value for the diagnosis of ALL. The diagnosis of acute leukaemia was easy to establish in most instances. However, in a ... | ['Adult', 'Cell Nucleus', 'Cell Size', 'Cytoplasm', 'Diagnosis, Differential', 'Histocytochemistry', 'Humans', 'Leukemia-Lymphoma, Adult T-Cell', 'Prospective Studies', 'T-Lymphocytes'] | 9,163,604 | [['M01.060.116'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['G04.325'], ['A11.284.430.214'], ['E01.171'], ['E01.370.225.500.607', 'E01.370.225.750.551', 'E05.200.500.607', 'E05.200.750.551', 'H01.158.100.656.234', 'H01.158.201.344', 'H01.181.122.573'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.5... | ['Named Groups [M]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Towards the core structure of Strychnos alkaloids using samarium diiodide-induced reactions of indole derivatives. | This report describes the development of a first and second generation approach towards the synthesis of the ABCEG pentacyclic core structure of Strychnos alkaloids. First, we discuss a sequential approach applying a series of functional group transformations to prepare suitable precursors for cyclization reactions. Th... | ['Alkaloids', 'Cyclization', 'Indoles', 'Iodides', 'Molecular Structure', 'Samarium', 'Strychnos'] | 24,273,006 | [['D03.132'], ['G02.111.180', 'G02.607.133', 'G03.208'], ['D03.633.100.473'], ['D01.248.497.158.490', 'D01.475.410'], ['G02.111.570', 'G02.466'], ['D01.268.558.362.937', 'D01.552.550.399.937'], ['B01.650.940.800.575.912.250.456.875.750']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Analytical evaluation and comparison of Dupont aca lactate dehydrogenase-1 (LD1) isoenzyme assay diagnostic efficiency for acute myocardial infarction detection with other LD1 methods and aca CK-MB. A two-site study. | The purpose of this study was to examine the analytical characteristics of a rapid new assay for lactate dehydrogenase 1 (LD1) isoenzyme on the Dupont aca analyzer and the diagnostic efficiency of LD1 for detection of acute myocardial infarction (AMI) when used alone and with creatine kinase MB (CKMB). Total aca LD1 as... | ['Chromatography, Ion Exchange', 'Creatine Kinase', 'Electrophoresis, Agar Gel', 'Female', 'Humans', 'Isoenzymes', 'L-Lactate Dehydrogenase', 'Male', 'Myocardial Infarction', 'Predictive Value of Tests', 'Prevalence', 'Reference Values', 'Retrospective Studies', 'Sensitivity and Specificity', 'Single-Blind Method'] | 8,024,157 | [['E05.196.181.400.383'], ['D08.811.913.696.640.150'], ['E05.196.401.153', 'E05.301.300.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.348', 'D12.776.800.300'], ['D08.811.682.047.551.400', 'D08.811.682.047.820.493'], ['C14.280.647.500', 'C14.907.585.500', 'C23.550.513.355.750', 'C23.550.717.489.750']... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Crystal structure of a Flp recombinase-Holliday junction complex: assembly of an active oligomer by helix swapping. | The crystal structure of a Flp recombinase tetramer bound to a Holliday junction intermediate has been determined at 2.65 A resolution. Only one of Flp's two domains, containing the active site, is structurally related to other lambda integrase family site-specific recombinases, such as Cre. The Flp active site differs... | ['Amino Acid Sequence', 'Base Sequence', 'Binding Sites', 'Crystallography, X-Ray', 'DNA', 'DNA Nucleotidyltransferases', 'Models, Genetic', 'Models, Molecular', 'Molecular Sequence Data', 'Nucleic Acid Conformation', 'Oligodeoxyribonucleotides', 'Protein Conformation', 'Protein Structure, Secondary', 'Recombination, G... | 11,090,626 | [['G02.111.570.060', 'L01.453.245.667.060'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G02.111.570.120'], ['E05.196.309.742.225'], ['D13.444.308'], ['D08.811.913.696.445.308'], ['E05.599.395.397'], ['E05.599.595'], ['L01.453.245.667'], ['G02.111.570.820.486', 'G05.360.580'], ['D13.695.578.424.450'], ... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Identification and partial characterization of a Mr 40,000 nucleolar antigen associated with cell proliferation. | The present study reports the identification and partial characterization of a novel Mr 40,000 nucleolar antigen (P40) by monoclonal antibodies. Monoclonal antibodies to this protein were obtained when a nucleolar protein extract separated from the immunodominant protein C23 was used to immunize BALB/c mice; 12 hybrido... | ['Animals', 'Antibodies, Monoclonal', 'Antigens, Neoplasm', 'Histocytochemistry', 'Humans', 'Interphase', 'Kidney', 'Leukemia, Myeloid, Acute', 'Leukocytes', 'Liver', 'Mice', 'Mice, Inbred BALB C', 'Microscopy, Phase-Contrast', 'Molecular Weight', 'Nuclear Proteins', 'Nucleoproteins', 'Proliferating Cell Nuclear Antige... | 2,879,624 | [['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D23.050.285'], ['E01.370.225.500.607', 'E01.370.225.750.551', 'E05.200.500.607', 'E05.200.750.551', 'H01.158.100.656.234', 'H01.158.201.344', 'H01.181.122.573'], ['B01.050.150.900.649.313.988.400.112.400.400']... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Management of Completion and Total Thyroidectomy Patients Based on 1-Hour Postoperative Parathyroid Hormone. | After thyroid surgery, protocols based on postoperative parathyroid hormone (PTH) levels may prevent symptoms of hypocalcemia, while avoiding unnecessary prophylactic calcium and/or vitamin D supplementation. We examined the value of an initial management protocol based solely on a single PTH level measured one hour af... | ['Adult', 'Aged', 'California', 'Cohort Studies', 'Disease Management', 'Dose-Response Relationship, Drug', 'Drug Administration Schedule', 'Female', 'Follow-Up Studies', 'Hospitals, University', 'Humans', 'Hypocalcemia', 'Male', 'Middle Aged', 'Parathyroid Hormone', 'Postoperative Care', 'Retrospective Studies', 'Risk... | 27,779,965 | [['M01.060.116'], ['M01.060.116.100'], ['Z01.107.567.875.580.200', 'Z01.107.567.875.760.200'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['N04.590.607'], ['G07.690.773.875', 'G07.690.936.500'], ['E02.319.283'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.... | ['Named Groups [M]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
An atypical case of dengue haemorrhagic fever presenting as quadriparesis due to compressive myelopathy. | Dengue haemorrhagic fever is a serious presentation of dengue viral infection. Case reports of cerebral haemorrhage due to dengue are rare. The authors report a rare case of dengue haemorrhagic fever presenting with fever and acute onset progressive quadriparesis of the upper motor neuron type. Rare cases of quadripare... | ['Adult', 'Cervical Vertebrae', 'Humans', 'Male', 'Quadriplegia', 'Severe Dengue', 'Spinal Cord Compression'] | 22,700,077 | [['M01.060.116'], ['A02.835.232.834.151'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.597.622.760', 'C23.888.592.636.786'], ['C01.920.500.270.200', 'C01.925.081.270.200', 'C01.925.782.350.250.214.200', 'C01.925.782.417.214.200'], ['C10.228.854.761', 'C26.819.678']] | ['Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Chemopreventive action of Phyllanthus urinaria Linn on DMBA-induced skin carcinogenesis in mice. | The inhibition of tumor incidence by hydro-alcoholic extract of the whole plant of P. urinaria was evaluated in 6-7 weeks old female albino mice on two-stage process of skin carcinogenesis induced by a single application of 7,12-dimethylbenz(a)anthracene (50 microg/50 microl of acetone), and 2 weeks later, promoted by ... | ['9,10-Dimethyl-1,2-benzanthracene', 'Animals', 'Carcinogens', 'Chemoprevention', 'Croton Oil', 'Female', 'Mice', 'Papilloma', 'Phyllanthus', 'Phytotherapy', 'Plant Extracts', 'Skin Neoplasms'] | 15,332,506 | [['D02.455.426.559.847.149.301', 'D04.615.149.301'], ['B01.050'], ['D27.888.569.100'], ['E02.319.162'], ['D10.212.507.375', 'D10.627.700.315', 'D20.215.784.750.315'], ['B01.050.150.900.649.313.992.635.505.500'], ['C04.557.470.700.600'], ['B01.650.940.800.575.912.250.859.797.438.622'], ['E02.190.755'], ['D20.215.784.500... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Intensive short-term chemotherapy regimen induces high remission rate (over 90%) and event-free survival both in children and adult patients with advanced sporadic Burkitt lymphoma/leukemia. | The optimal treatment of advanced sporadic Burkitt lymphoma in adults is still a matter of debate. The salutary results of pediatric therapies did open the road for improving the adult outcome. Between May 1988 and March 2009, 71 consecutive patients-46 adults, 25 children-affected by Burkitt lymphoma/leukemia were tre... | ['Adolescent', 'Adult', 'Aged', 'Antibodies, Monoclonal, Murine-Derived', 'Antineoplastic Agents', 'Antineoplastic Combined Chemotherapy Protocols', 'Burkitt Lymphoma', 'Child', 'Child, Preschool', 'Disease-Free Survival', 'Female', 'Hematopoietic Stem Cell Transplantation', 'Humans', 'Male', 'Middle Aged', 'Neoplasm S... | 22,086,870 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['D12.776.124.486.485.114.224.075', 'D12.776.124.790.651.114.224.075', 'D12.776.377.715.548.114.224.284'], ['D27.505.954.248'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['C01.925.256.466.313.165', 'C01.925.928.313.165', 'C04.557.386.480.150.165',... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A novel electrode with electromagnetic tip tracking in ultrasonography-guided radiofrequency ablation: a phantom, ex vivo, and in vivo experimental study. | OBJECTIVES: The objective of this study was to compare the targeting and ablation performance between a newly developed radiofrequency (RF) electrode embedded with an electromagnetic position sensor (EMPS) at the electrode tip and a conventional RF electrode.MATERIALS AND METHODS: The institutional animal care and use ... | ['Animals', 'Catheter Ablation', 'Cattle', 'Electromagnetic Fields', 'In Vitro Techniques', 'Liver', 'Magnetics', 'Phantoms, Imaging', 'Surgery, Computer-Assisted', 'Ultrasonography'] | 25,360,604 | [['B01.050'], ['E02.808.750.500', 'E04.014.760.500'], ['B01.050.150.900.649.313.500.380.271'], ['G01.358.500.260', 'G01.358.750.500'], ['E05.481'], ['A03.620'], ['H01.671.493'], ['E07.671'], ['E04.749'], ['E01.370.350.850']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Spontaneous fractures in custom-made porous hydroxyapatite cranioplasty implants: is fragility the only culprit? | BACKGROUND: Although the porous hydroxyapatite (PHA) used in custom-made cranioplasty implants is a material appreciated for its biomimetic properties, before osteointegration it is initially very fragile. Nevertheless, we wondered whether this primary fragility is entirely due to brittleness or whether the surgeon's a... | ['Computer Simulation', 'Durapatite', 'Humans', 'Models, Biological', 'Prostheses and Implants', 'Prosthesis Failure', 'Skull'] | 25,588,747 | [['L01.224.160'], ['D01.029.260.700.675.374.075.025.300.150', 'D01.146.360.050.300.200', 'D01.578.122.477.300', 'D01.695.625.675.650.075.025.300.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.395'], ['E07.695'], ['C23.550.767.865', 'E05.325.771'], ['A02.835.232.781']] | ['Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Mediated amperometric immunosensing using single walled carbon nanotube forests. | A prototype amperometric immunosensor was evaluated based on the adsorption of antibodies onto perpendicularly oriented assemblies of single wall carbon nanotubes called SWNT forests. The forests were self-assembled from oxidatively shortened SWNTs onto Nafion/iron oxide coated pyrolytic graphite electrodes. The nanotu... | ['Adsorption', 'Animals', 'Antibodies', 'Biosensing Techniques', 'Electrochemistry', 'Microchemistry', 'Microscopy, Atomic Force', 'Nanotubes, Carbon', 'Spectrum Analysis, Raman'] | 15,565,214 | [['G01.030', 'G02.020'], ['B01.050'], ['D12.776.124.486.485.114', 'D12.776.124.790.651.114', 'D12.776.377.715.548.114'], ['E05.601.043'], ['H01.181.529.307'], ['E05.196.620', 'H01.181.650'], ['E01.370.350.515.666.400', 'E05.595.666.400'], ['D01.268.150.250.500', 'J01.637.512.850.500'], ['E05.196.822.860', 'E05.196.867.... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Peroxisome-proliferator-activated receptors and the control of levels of prostaglandin-endoperoxide synthase 2 by arachidonic acid in the bovine uterus. | Arachidonic acid is a potential paracrine agent released by the uterine endometrial epithelium to induce PTGS2 [PG (prostaglandin)-endoperoxide synthase 2] in the stroma. In the present study, bovine endometrial stromal cells were used to determine whether PTGS2 is induced by arachidonic acid in stromal cells, and to i... | ['Animals', 'Arachidonic Acid', 'Cattle', 'Cyclooxygenase 2', 'Enzyme Induction', 'Female', 'Gene Expression Regulation', 'Isoenzymes', 'Models, Biological', 'PPAR alpha', 'PPAR delta', 'PPAR gamma', 'Peroxisome Proliferator-Activated Receptors', 'Prostaglandins', 'Protein Kinase C', 'Uterus'] | 17,516,915 | [['B01.050'], ['D10.251.355.255.100.100', 'D10.251.355.310.166.100'], ['B01.050.150.900.649.313.500.380.271'], ['D08.811.600.720.750'], ['G05.308.320.200'], ['G05.308'], ['D08.811.348', 'D12.776.800.300'], ['E05.599.395'], ['D12.776.826.239.500'], ['D12.776.826.239.555'], ['D12.776.826.239.588'], ['D12.776.826.239', 'D... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Increased apoptosis of motoneurons and altered somatotopic maps in the brachial spinal cord of Hoxc-8-deficient mice. | Mice deficient for the homeotic gene Hoxc-8 suffer from a congenital prehension deficiency of the forepaw. During embryogenesis, Hoxc-8 is highly expressed in motoneurons within spinal cord segments C7 to T1. These motoneurons innervate forelimb distal muscles that move the forepaw. In Hoxc-8 mutant embryos, formation ... | ['Animals', 'Apoptosis', 'Central Nervous System', 'Crosses, Genetic', 'Disease Models, Animal', 'Foot', 'Forelimb', 'Hand Strength', 'Homeodomain Proteins', 'Mice', 'Mice, Inbred DBA', 'Mice, Neurologic Mutants', 'Motor Neurons', 'Muscle, Skeletal', 'Neuromuscular Diseases', 'Phenotype', 'Recombinant Fusion Proteins',... | 9,486,801 | [['B01.050'], ['G04.146.954.035'], ['A08.186'], ['E05.393.281'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['A01.378.610.250'], ['A13.395'], ['E01.370.600.425.500', 'G11.427.560.500'], ['D12.776.260.400'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.500', 'B01.050.150.900.649.313.992.635... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Preliminary report on some clinical and biochemical observations in patients treated with Bilharcid. | Tartar emetic (potassium antimony tartrate) has been used since a long time as the drug of choice for the treatment of Bilharziasis in Egypt. This drug, though effective, has severe side effects. A newly synthesized trivalent antimony preparation (piperazine di-antimonyl tratrate) Bilharcid, has proved in animal experi... | ['Adolescent', 'Adult', 'Animals', 'Antimony', 'Antimony Potassium Tartrate', 'Child', 'Drug Administration Schedule', 'Drug Evaluation', 'Egypt', 'Haplorhini', 'Heart', 'Humans', 'Liver', 'Male', 'Mice', 'Piperazines', 'Schistosomiasis', 'Schistosomicides', 'Urea', 'Urinary Tract Infections'] | 810,341 | [['M01.060.057'], ['M01.060.116'], ['B01.050'], ['D01.268.513.124', 'D01.268.556.050', 'D01.552.544.050'], ['D02.121'], ['M01.060.406'], ['E02.319.283'], ['E05.290.625', 'E05.337.425'], ['Z01.058.266.317'], ['B01.050.150.900.649.313.988.400'], ['A07.541'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A03.620'], [... | ['Named Groups [M]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
Sodium azide-induced mutagenesis in Saccharomyces cerevisiae. | Sodium azide (0.5--2.0 X 10(-5) M), applied for 24 h on cells growing in complete medium, increased up to 26 times the frequency of reversions and locus-specific suppressor mutations of allele ilv1-92 in diploid strain D7 of Saccharomyces cerevisiae. Similarly, it enhanced the frequency of reversions and/or mitotic gen... | ['Azides', 'Culture Media', 'Hydrogen-Ion Concentration', 'Mutagens', 'Mutation', 'Saccharomyces cerevisiae'] | 39,251 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Gait changes in elderly people]. | Age-associated changes in gait produce a decrease in walking velocity, predominantly caused by a reduction in the length of the step and to a lesser degree in cadence. The length of the step becomes shorter because of impaired balance, diminished muscle strength and muscle contractures that decrease the joint range of ... | ['Aged', 'Aged, 80 and over', 'Aging', 'Exercise Therapy', 'Female', 'Gait', 'Humans', 'Joint Prosthesis', 'Male', 'Muscle Contraction', 'Orthotic Devices', 'Postural Balance'] | 8,134,099 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['G07.345.124'], ['E02.760.169.063.500.387', 'E02.779.483', 'E02.831.535.483'], ['E01.370.600.250', 'G11.427.410.568.900.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E07.695.400'], ['G11.427.494'], ['E07.858.442.743'], ['F02.830.816.541.752', 'G07.888.750.500'... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Descriptive terms for women attending antenatal clinics: mother knows best? | OBJECTIVE: To determine the noun for 'women who attend antenatal clinics' that is most accepted by the women themselves.DESIGN: Cross sectional study.SETTING: Consultant-led antenatal clinics in Cornwall.POPULATION: All women attending consultant-led antenatal clinics over a two-month period.METHODS: The women were sur... | ['Adolescent', 'Adult', 'Attitude to Health', 'Cohort Studies', 'Cross-Sectional Studies', 'Female', 'Humans', 'Pregnancy', 'Prenatal Care', 'Terminology as Topic'] | 11,028,573 | [['M01.060.057'], ['M01.060.116'], ['F01.100.150', 'N05.300.150'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G08.686.784.769'], ['E02.760.786', 'N02.421.... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Using quantitative acid-base analysis in the ICU. | The quantitative acid-base 'Strong Ion' calculator is a practical application of quantitative acid-base chemistry, as developed by Peter Stewart and Peter Constable. It quantifies the three independent factors that control acidity, calculates the concentration and charge of unmeasured ions, produces a report based on t... | ['Acid-Base Equilibrium', 'Acid-Base Imbalance', 'Acute Kidney Injury', 'Adult', 'Aged', 'Algorithms', 'Child', 'Diabetic Ketoacidosis', 'Female', 'Humans', 'Intensive Care Units', 'Male', 'Middle Aged', 'Rhabdomyolysis', 'Status Asthmaticus'] | 16,536,715 | [['G02.111.007', 'G02.300.176', 'G03.030', 'G07.410.110', 'G09.188.050'], ['C18.452.076'], ['C12.777.419.780.050', 'C13.351.968.419.780.050'], ['M01.060.116'], ['M01.060.116.100'], ['G17.035', 'L01.224.050'], ['M01.060.406'], ['C18.452.076.176.652.500', 'C18.452.394.750.535', 'C19.246.099.812'], ['B01.050.150.900.649.3... | ['Phenomena and Processes [G]', 'Diseases [C]', 'Named Groups [M]', 'Information Science [L]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
[Posterior cranial fossa tumours as a cause of sudden hearing deterioration and/or vertigo]. | INTRODUCTION: The aim of the work was to analyse sudden deterioration of hearing and/or vertigo occurrence as an early symptom of posterior cranial fossa tumours.MATERIAL AND METHODS: Among 1.394 people who reported vertigo and hearing impairment and were hospitalised at the Department of Otolaryngology and Laryngologi... | ['Acoustic Impedance Tests', 'Adult', 'Aged', 'Auditory Threshold', 'Cerebral Ventricle Neoplasms', 'Cranial Fossa, Posterior', 'Female', 'Hearing Loss, Sensorineural', 'Humans', 'Male', 'Middle Aged', 'Poland', 'Severity of Illness Index', 'Tinnitus', 'Vertigo', 'Young Adult'] | 22,000,258 | [['E01.370.382.375.050'], ['M01.060.116'], ['M01.060.116.100'], ['F02.463.593.071.173', 'F02.463.593.710.190', 'G07.888.125.173'], ['C04.588.614.250.195.205', 'C10.228.140.211.280', 'C10.551.240.250.200'], ['A01.456.830.200', 'A02.835.232.781.750.400'], ['C09.218.458.341.887', 'C10.597.751.418.341.887', 'C23.888.592.76... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Geographicals [Z]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
[Importance of moulds in the morphogenesis of pulmonary changes in chronic infantile granulomatosis]. | A brief clinical and a rather detailed histological decription is given of three male siblings suffering from chronic granulomatosis. Two types of granulomas were indentified. One of them occurring extrapulmonally resembled the specific tuberculous granuloma with caseation, but tuberculous bacilli not demonstrated. The... | ['Adult', 'Aspergillosis', 'Child', 'Female', 'Granulomatous Disease, Chronic', 'Humans', 'Infant', 'Lung Diseases, Fungal', 'Male', 'Phagocyte Bactericidal Dysfunction', 'Sex Factors'] | 1,212,702 | [['M01.060.116'], ['C01.150.703.080'], ['M01.060.406'], ['C15.378.553.774.535', 'C16.320.322.233', 'C20.673.774.535'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['C01.150.703.534', 'C01.748.435', 'C08.381.472', 'C08.730.435'], ['C15.378.553.774', 'C20.673.774'], ['N05.715.350.675', 'N06.850.490.... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Effects of physical exercise on liver ATP levels in fasted and phosphate-injected rats. | The purpose of the present study was to investigate the effects of exercise (30 min, 23 m/min, 0% grade) on the hepatic levels of ATP in fasted adrenodemedullated rats, with an intraperitoneal injection of sodium phosphate (Na (2) PO (4 ), 0.91 mM) or saline (NaCl). Sodium phosphate was injected to determine if the pos... | ['Adenosine Triphosphate', 'Adrenal Medulla', 'Animals', 'Blood Glucose', 'Chromatography, High Pressure Liquid', 'Epinephrine', 'Fasting', 'Glucagon', 'Hepatic Veins', 'Insulin', 'Lactic Acid', 'Liver', 'Liver Glycogen', 'Male', 'Norepinephrine', 'Phosphates', 'Physical Conditioning, Animal', 'Rats', 'Rats, Sprague-Da... | 10,916,167 | [['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['A06.300.071.265'], ['B01.050'], ['D09.947.875.359.448.500'], ['E05.196.181.400.300'], ['D02.033.100.291.310', 'D02.092.063.291.310', 'D02.092.211.215.454', 'D02.092.311.461', 'D02.455.426.559.389.657.166.175.461'], ['F01.145.407.400', 'G0... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Participating or not in a cardiac rehabilitation programme: factors influencing a patient's decision. | BACKGROUND: International research indicates that attendance of patients to a proposed cardiac rehabilitation (CR) programme varies between 21% and 75%. Addressing the reasons why cardiac patients are not participating will improve accessibility to CR. The objective of this study was to investigate patient compliance w... | ['Adult', 'Aged', 'Aged, 80 and over', 'Awareness', 'Belgium', 'Cardiac Surgical Procedures', 'Culture', 'Female', 'Health Care Costs', 'Health Care Surveys', 'Health Knowledge, Attitudes, Practice', 'Health Services Accessibility', 'Heart Diseases', 'Humans', 'Male', 'Middle Aged', 'Patient Compliance', 'Patient Dropo... | 22,345,682 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['F02.463.188.150'], ['Z01.542.115'], ['E04.100.376', 'E04.928.220'], ['I01.076.201.450', 'I01.880.853.100'], ['N03.219.151.400', 'N05.300.375'], ['E05.318.308.980.344', 'N03.349.380.210', 'N05.425.210', 'N05.715.360.300.800.344', 'N06.850.520.308.980.344'... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
The third biannual winter workshop on schizophrenia. Schladming, Austria, Jan 26-31, 1986. | The following general principles seem to summarize the emphasis that was evident from the several days of multiple presentations and discussions. The need exists to continue to develop improvements in the tools applicable to research in psychiatry, both clinical and biological "instruments" that are both sensitive and ... | ['Humans', 'Research', 'Schizophrenia'] | 3,718,172 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['H01.770.644'], ['F03.700.750']] | ['Organisms [B]', 'Disciplines and Occupations [H]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Apoptosis and morphological alterations after UVA irradiation in red blood cells of p53 deficient Japanese medaka (Oryzias latipes). | Morphological alterations in red blood cells were described as hematological bioindicators of UVA exposure to investigate the sensitivity to UVA in wild type Japanese medaka (Oryzias latipes) and a p53 deficient mutant. The fewer abnormal red blood cells were observed in the p53 mutant fish under the control conditions... | ['Animals', 'Apoptosis', 'Erythrocytes', 'Fish Proteins', 'Microscopy', 'Oryzias', 'Tumor Suppressor Protein p53', 'Ultraviolet Rays'] | 27,203,565 | [['B01.050'], ['G04.146.954.035'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['D12.776.325'], ['E01.370.350.515', 'E05.595', 'H01.671.617.562'], ['B01.050.150.900.493.850.139.650'], ['D12.776.157.687.650', 'D12.776.260.820', 'D12.776.624.776.775', 'D12.776.660.720.650', 'D12.776.744.845'], ['G01.358.500.505.65... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Direct interaction of Na-azide with the KATP channel. | 1. The effects of the metabolic inhibitor sodium azide were tested on excised macropatches from Xenopus oocytes expressing cloned ATP-sensitive potassium (KATP) channels of the Kir6.2/SUR1 type. 2. In inside-out patches from oocytes expressing Kir6.2 delta C36 (a truncated form of Kir6.2 that expresses in the absence o... | ['Adenosine Triphosphate', 'Animals', 'Enzyme Inhibitors', 'Female', 'Glycosyltransferases', 'Membrane Proteins', 'Mice', 'Potassium Channels', 'Rats', 'Receptors, Immunologic', 'Receptors, KIR', 'Repressor Proteins', 'Saccharomyces cerevisiae Proteins', 'Sodium Azide', 'Sodium Chloride', 'Xenopus laevis'] | 11,082,117 | [['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['B01.050'], ['D27.505.519.389'], ['D08.811.913.400'], ['D12.776.543'], ['B01.050.150.900.649.313.992.635.505.500'], ['D12.776.157.530.400.600', 'D12.776.543.550.450.750', 'D12.776.543.585.400.750'], ['B01.050.150.900.649.313.992.635.505.70... | ['Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Comparison of the cognitive effects of tiagabine and carbamazepine as monotherapy in newly diagnosed adult patients with partial epilepsy: pooled analysis of two long-term, randomized, follow-up studies. | PURPOSE: Patients with epilepsy are at greater risk for cognitive impairment than are age- and education-matched controls. Cognitive decline is a significant adverse event associated with many first-generation anticonvulsant drugs (AEDs); however, the past decade has seen the introduction of several new AEDs with more-... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Anticonvulsants', 'Carbamazepine', 'Child', 'Cognition', 'Cognition Disorders', 'Dose-Response Relationship, Drug', 'Double-Blind Method', 'Drug Administration Schedule', 'Epilepsies, Partial', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Middle Aged', 'Neurops... | 16,886,974 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.954.427.080'], ['D03.633.300.240.127'], ['M01.060.406'], ['F02.463.188'], ['F03.615.250'], ['G07.690.773.875', 'G07.690.936.500'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['E02.319.28... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Daily grazing time as a risk factor for alterations at the hock joint integument in dairy cows. | Structural changes lead to increasing sizes of dairy herds and a reduction in grazing use. Thus, cows spend more time in the barn and become more exposed to the barn environment. The cubicle surface can result in damages of the cows' hock joint integument. Pasture is generally seen as a beneficial environment for cows.... | ['Animal Welfare', 'Animals', 'Cattle', 'Cattle Diseases', 'Dairying', 'Denmark', 'Feeding Behavior', 'Female', 'Lameness, Animal', 'Logistic Models', 'Prevalence', 'Risk Factors', 'Tarsus, Animal', 'Time Factors'] | 23,031,448 | [['I01.880.604.100'], ['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['C22.196'], ['J01.040.246'], ['Z01.542.816.124'], ['F01.145.113.547', 'F01.145.407', 'G07.203.650.353'], ['C22.510'], ['E05.318.740.500.525', 'E05.318.740.600.800.450', 'E05.318.740.750.450', 'E05.599.835.875', 'N05.715.360.750.530.480', 'N05.... | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Diseases [C]', 'Technology, Industry, and Agriculture [J]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', '... | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 |
Digital X-ray apparatus especially designed for precise biometry in stereotactic surgical procedures. | Modern stereotactic surgical procedures were developed mainly because digital CT image gave us the opportunity to recognize the morphology and the site of a brain lesion, and, at the same time, CT offered a very easy and reliable way to calculate target coordinates because the brain scans are digital maps. Digital x-ra... | ['Cephalometry', 'Cerebral Angiography', 'Humans', 'Magnetic Resonance Imaging', 'Neurosurgery', 'Radiographic Image Interpretation, Computer-Assisted', 'Stereotaxic Techniques', 'Subtraction Technique', 'Tomography, X-Ray Computed'] | 1,792,969 | [['E01.370.600.024.250', 'E05.041.250', 'N06.850.505.200.100.300'], ['E01.370.350.578.937.180', 'E01.370.350.700.060.180', 'E01.370.350.700.560.180', 'E01.370.370.050.180', 'E01.370.376.537.750.180', 'E05.629.937.180'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['H02.403.810.425'], ['E01... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Peptide inhibitors of fibronectin, laminin, and other adhesion molecules: unique and shared features. | Synthetic peptides can specifically inhibit the function of certain adhesive glycoproteins in vitro and in vivo. We have compared the relative activities of a set of six variant synthetic peptides based on the sequence of fibronectin in terms of their ability to inhibit the interactions of fibroblasts with fibronectin,... | ['Amino Acid Sequence', 'Animals', 'Antigens, Surface', 'Cell Adhesion', 'Cell Adhesion Molecules', 'Cell Line', 'Collagen', 'Cricetinae', 'Fibronectins', 'Kidney', 'Kinetics', 'Laminin', 'Peptides', 'Structure-Activity Relationship'] | 3,805,128 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D23.050.301'], ['G04.022'], ['D12.776.395.550.200', 'D12.776.543.550.200', 'D23.050.301.350'], ['A11.251.210'], ['D05.750.078.280', 'D12.776.860.300.250'], ['B01.050.150.900.649.313.992.635.075.250'], ['D12.776.377.715.390', 'D12.776.395.550.350', 'D12.776.543... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Mortality in neurofibromatosis 1: an analysis using U.S. death certificates. | Although neurofibromatosis 1 (NF1) is a relatively common autosomal dominant condition, information about its effect on mortality is limited. We used Multiple-Cause Mortality Files, compiled from U.S. death certificates by the National Center for Health Statistics, for 1983 through 1997. We identified 3,770 cases of pr... | ['Adolescent', 'Adult', 'Age Factors', 'Aged', 'Child', 'Continental Population Groups', 'Death Certificates', 'Female', 'Humans', 'Life Expectancy', 'Male', 'Middle Aged', 'Neurofibromatosis 1', 'Time Factors', 'United States', 'Vascular Diseases'] | 11,283,797 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['M01.060.406'], ['M01.686.508'], ['E05.318.308.940.350', 'L01.399.250.900.350', 'N04.452.859.264', 'N05.715.360.300.715.315', 'N06.850.520.308.940.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.45... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
[Effects of human adipose-derived mesenchymal stem cells and platelet-rich plasma on healing of wounds with full-thickness skin defects in mice]. | Objective: To investigate the effects of human adipose-derived mesenchymal stem cells (ADSCs) and platelet-rich plasma (PRP) on healing of wounds with full-thickness skin defects in mice. Methods: ADSCs were isolated from the lumbar and abdominal fat donated voluntarily by a healthy woman undergoing liposuction in the ... | ['Animals', 'Burns', 'Female', 'Humans', 'Mesenchymal Stem Cells', 'Mice', 'Mice, Inbred C57BL', 'Platelet-Rich Plasma', 'Skin', 'Wound Healing'] | 30,585,053 | [['B01.050'], ['C26.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.329.830.500', 'A11.872.590.500'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420'], ['A12.207.152.693.600', 'A12.207.270.695.600', 'A15.145.693.600'], ['A17.81... | ['Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Is mechanical bowel preparation really necessary in colorectal surgery? | OBJECTIVE: To determine the outcome of colorectal surgery without mechanical bowel preparation.DESIGN: A descriptive, analytical and observational study.PLACE AND DURATION OF STUDY: Combined Military Hospital, Kharian and Pano Aqil, from September 1998 to April 2003.SUBJECTS AND METHODS: Forty-seven patients underwent ... | ['Adolescent', 'Adult', 'Aged', 'Anastomosis, Surgical', 'Antibiotic Prophylaxis', 'Cathartics', 'Child', 'Child, Preschool', 'Cohort Studies', 'Colonic Diseases', 'Colorectal Surgery', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Middle Aged', 'Postoperative Complications', 'Preoperative Care', 'Rectal Diseases',... | 14,700,490 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['E04.035'], ['E02.319.162.150', 'E02.319.703.150'], ['D27.505.954.483.396'], ['M01.060.406'], ['M01.060.406.448'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['C06.405.469.158'], ['H02.403.810.208'], ['E05.318.372.500.750.249',... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Diseases [C]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Development of a protective immunity against Ostertagia leptospicularis in trickle-infected sheep and parallel changes of serum gastrin, pepsinogen and antibody levels. | Nine lambs, approximately 9 months of age were allocated to three groups (A, B, C), with three animals in each. Sheep in Groups A and B were trickle-infected with doses of 1000 third-stage larvae (L3) of Ostertagia leptospicularis (five times per week) over periods of 7.5 and 10.5 weeks, respectively, and were subseque... | ['Animals', 'Antibodies, Helminth', 'Antinematodal Agents', 'Feces', 'Female', 'Fenbendazole', 'Gastrins', 'Immunization', 'Larva', 'Male', 'Ostertagia', 'Ostertagiasis', 'Parasite Egg Count', 'Pepsinogen A', 'Sheep', 'Sheep Diseases', 'Time Factors'] | 10,204,410 | [['B01.050'], ['D12.776.124.486.485.114.185', 'D12.776.124.790.651.114.185', 'D12.776.377.715.548.114.185'], ['D27.505.954.122.250.075.080'], ['A12.459'], ['D02.241.081.251.320', 'D03.633.100.103.450'], ['D06.472.317.413', 'D06.472.699.280', 'D12.644.400.320', 'D12.644.548.280', 'D12.776.631.650.320'], ['E02.095.465.42... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
The pknH gene restrictively expressed in heterocysts is required for diazotrophic growth in the cyanobacterium Anabaena sp. strain PCC 7120. | Anabaena sp. strain PCC 7120 is a filamentous cyanobacterium in which certain vegetative cells differentiate into heterocysts, which are specialized cells for nitrogen fixation. Heterocysts are unable to carry out photosynthesis and are supplied with carbohydrate required for nitrogen fixation from neighbouring vegetat... | ['Anabaena', 'Bacterial Proteins', 'Gene Expression Regulation, Bacterial', 'Gene Expression Regulation, Developmental', 'Gene Expression Regulation, Enzymologic', 'Protein-Serine-Threonine Kinases'] | 22,383,473 | [['B03.280.100', 'B03.440.475.100.100', 'B03.585.051'], ['D12.776.097'], ['G05.308.300'], ['G05.308.310'], ['G05.308.320'], ['D08.811.913.696.620.682.700']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Novel bacterial membrane surface display system using cell wall-less L-forms of Proteus mirabilis and Escherichia coli. | We describe a novel membrane surface display system that allows the anchoring of foreign proteins in the cytoplasmic membrane (CM) of stable, cell wall-less L-form cells of Escherichia coli and Proteus mirabilis. The reporter protein, staphylokinase (Sak), was fused to transmembrane domains of integral membrane protein... | ['Bacterial Outer Membrane Proteins', 'Cell Membrane', 'Escherichia coli', 'L Forms', 'Membrane Proteins', 'Metalloendopeptidases', 'Microscopy, Electron', 'Proteus mirabilis', 'Recombinant Fusion Proteins', 'Trypsin'] | 11,823,186 | [['D12.776.097.120', 'D12.776.543.100'], ['A11.284.149'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['B03.110.422', 'B05.110.422'], ['D12.776.543'], ['D08.811.277.656.300.480', 'D08.811.277.656.675.374'], ['E01.370.350.515.402', 'E05.595.402'], ['B03.440.450.425.600.501', 'B03.660.250.150.590.500'], ['D12... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Maternal cocaine treatment alters dynorphin and enkephalin mRNA expression in brains of fetal rhesus macaques. | Cocaine exposure in utero is known to cause a variety of behavioral and motor deficits that may be attributable to alterations in the dopamine neurocircuitry. To ascertain cocaine effects in the fetus, we developed a nonhuman primate model in which pregnant monkeys were administered cocaine from day 20 through day 60 o... | ['Animals', 'Brain', 'Cocaine', 'Dynorphins', 'Enkephalins', 'Female', 'Gene Expression Regulation', 'Macaca mulatta', 'Narcotics', 'Pregnancy', 'Protein Precursors', 'RNA, Messenger'] | 8,994,065 | [['B01.050'], ['A08.186.211'], ['D02.145.074.722.388', 'D03.132.889.354', 'D03.605.084.500.722.388', 'D03.605.869.388'], ['D12.644.400.575.180', 'D12.776.631.650.575.180'], ['D12.644.400.575.281', 'D12.776.631.650.575.281'], ['G05.308'], ['B01.050.150.900.649.313.988.400.112.199.120.510.550'], ['D27.505.696.277.600', '... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Hemodynamic responses to supine exercise in children with left-sided cardiac disease. | Exercise, a physiologic stress, has been used in adults to unmask abnormalities of left ventricular hemodynamics not detectable at rest. Similar data in children are not available. An evaluation was made of the feasibility, safety and value of a graded upright and supine ergometer stress test to assess exercise hemodyn... | ['Adolescent', 'Aorta', 'Aortic Valve', 'Blood Pressure', 'Cardiac Catheterization', 'Cardiac Output', 'Child', 'Echocardiography', 'Electrocardiography', 'Exercise Test', 'Heart Diseases', 'Hemodynamics', 'Humans', 'Pulmonary Artery', 'Vascular Resistance'] | 7,369,133 | [['M01.060.057'], ['A07.015.114.056'], ['A07.541.510.110'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E01.370.370.380.140', 'E02.148.442', 'E05.157.250'], ['E01.370.370.380.150', 'G09.330.380.124'], ['M01.060.406'], ['E01.370.350.130.750', 'E01.370.350.850.220', 'E01.370.370.380.220'], ['E01.370.370.380.240', 'E01.... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Efficacy and safety of nifedipine GITS in Asians with hypertension: results of a post-marketing surveillance study in China. | OBJECTIVE: This post-marketing surveillance study assessed the efficacy, safety and tolerability of treatment with nifedipine GITS (gastrointestinal therapeutic system) in hypertensive patients with different risk profiles under normal daily practice conditions in China.METHODS: A total of 7395 patients were included i... | ['Asian Continental Ancestry Group', 'Blood Pressure', 'Calcium Channel Blockers', 'China', 'Female', 'Humans', 'Hypertension', 'Male', 'Middle Aged', 'Nifedipine', 'Product Surveillance, Postmarketing', 'Prospective Studies'] | 17,638,397 | [['M01.686.508.200'], ['E01.370.600.875.249', 'G09.330.380.076'], ['D27.505.519.562.249', 'D27.505.696.260.500', 'D27.505.954.411.192'], ['Z01.252.474.164'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['M01.060.116.630'], ['D03.383.725.203.540'], ['E05.337.800'], ['E05.318.372.500.750.625', 'N05.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Male-specific beta-cell dysfunction and diabetes resulting from increased expression of a syngeneic MHC class I protein in the pancreata of transgenic mice. | It is well established that insulin-dependent diabetes (IDDM) is an autoimmune disease with a strong genetic link to the HLA locus. It is less well understood, however, how the destruction of the insulin-producing beta cells is effected and why neighboring non-beta islet cells are spared. Also incompletely explained ar... | ['Animals', 'Dexamethasone', 'Diabetes Mellitus, Type 1', 'Female', 'Histocompatibility Antigens Class I', 'Incidence', 'Islets of Langerhans', 'Male', 'Mice', 'Mice, Transgenic', 'Ovariectomy', 'Simplexvirus', 'Testosterone', 'Viral Envelope Proteins'] | 1,965,148 | [['B01.050'], ['D04.210.500.745.432.769.344', 'D04.210.500.908.238'], ['C18.452.394.750.124', 'C19.246.267', 'C20.111.327'], ['D12.776.395.550.489', 'D12.776.543.550.439', 'D23.050.301.500.100', 'D23.050.705.552.100'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.98... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
A systems approach to assess farm-scale nutrient and trace element dynamics: a case study at the Ojebyn dairy farm. | A systems analysis approach was used to assess farmscale nutrient and trace element sustainability by combining full-scale field experiments with specific studies of nutrient release from mineral weathering and trace-element cycling. At the Ojebyn dairy farm in northern Sweden, a farm-scale case study including phospho... | ['Animal Husbandry', 'Animals', 'Cattle', 'Dairying', 'Female', 'Phosphorus', 'Potassium', 'Soil', 'Sweden', 'Systems Analysis', 'Trace Elements', 'Zinc'] | 16,092,260 | [['J01.040.090'], ['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['J01.040.246'], ['D01.268.666'], ['D01.268.549.550', 'D01.268.557.575', 'D01.552.528.652', 'D01.552.547.650'], ['D20.721', 'G01.311.820', 'G16.500.275.815', 'N06.230.600'], ['Z01.542.816.500'], ['L01.906'], ['D01.268.811', 'D27.505.696.494.555', '... | ['Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Geographicals [Z]', 'Information Science [L]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 |
Neurodegeneration in the rat hippocampus and striatum after middle cerebral artery occlusion. | Animal models of ischemia are in wide use to elucidate the molecular mechanisms of brain injury that result from cardiovascular disease in humans. We have used the fluorescent, anionic dye, Fluoro-Jade, to examine cellular degeneration that occurs in association with the middle cerebral artery occlusion (MCAO) model. M... | ['Animals', 'Arterial Occlusive Diseases', 'Astrocytes', 'Cerebral Arteries', 'Corpus Striatum', 'Fluoresceins', 'Fluorescent Dyes', 'Glial Fibrillary Acidic Protein', 'Hippocampus', 'Humans', 'Immunohistochemistry', 'Nerve Degeneration', 'Organic Chemicals', 'Rats', 'Rats, Sprague-Dawley', 'Time Factors'] | 11,864,631 | [['B01.050'], ['C14.907.137'], ['A08.637.200', 'A11.650.200'], ['A07.015.114.228'], ['A08.186.211.200.885.287.249.487'], ['D02.455.426.779.347', 'D03.633.300.953.275', 'D04.711.347'], ['D27.720.233.348', 'D27.720.470.410.505.500'], ['D05.750.078.593.400', 'D12.776.220.475.400'], ['A08.186.211.180.405', 'A08.186.211.200... | ['Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Acoustic monitoring of double-lumen ventilated lungs for the detection of selective unilateral lung ventilation. | One-lung intubation (OLI) is among the most common complications of endotracheal intubation. None of the monitoring tools now available has proved effective for its early detection. In this study we investigated the efficacy of acoustic analysis for the detection of OLI. We collected lung sounds from 11 patients underg... | ['Acoustics', 'Adult', 'Humans', 'Intubation, Intratracheal', 'Pilot Projects', 'Respiration, Artificial', 'Respiratory Sounds', 'Thoracic Surgical Procedures'] | 17,122,229 | [['H01.671.031'], ['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.041.500', 'E02.585.578', 'E05.497.578'], ['E05.318.372.750', 'E05.337.737', 'N05.715.360.330.720', 'N06.850.520.450.720'], ['E02.041.625', 'E02.365.647.729', 'E02.880.820'], ['C23.888.852.779', 'E01.370.386.720', 'G09.772.775'], [... | ['Disciplines and Occupations [H]', 'Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Specific binding of chloride ions to lipid vesicles and implications at molecular scale. | Biological membranes composed of lipids and proteins are in contact with electrolytes like aqueous NaCl solutions. Based on molecular dynamics studies it is widely believed that Na(+) ions specifically bind to 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) membranes, whereas Cl(-) ions stay in solution. Here, ... | ['Chlorides', 'Ion Transport', 'Liposomes', 'Membrane Potentials', 'Molecular Dynamics Simulation', 'Phosphatidylserines', 'Sodium', 'Water'] | 23,442,960 | [['D01.210.450.150', 'D01.248.497.158.215'], ['G03.143.500'], ['D25.479.517', 'D26.255.260.517', 'J01.637.051.479.517', 'J01.637.087.500.517'], ['G01.154.535', 'G04.580', 'G07.265.675', 'G11.561.570'], ['E05.599.595.500', 'G02.111.570.895', 'L01.224.160.500'], ['D10.570.755.375.760.400.971'], ['D01.268.549.750', 'D01.2... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Optimization of immunosuppressive therapy for spinal grafting of human spinal stem cells in a rat model of ALS. | Previous rodent studies employing monotherapy or combined immunosuppressive regimens have demonstrated a variable degree of spinal xenograft survival in several spinal neurodegenerative models including spinal ischemia, trauma, or amyotrophic lateral sclerosis (ALS). Accordingly, the characterization of optimal immuno... | ['Amyotrophic Lateral Sclerosis', 'Animals', 'Cell Survival', 'Disease Models, Animal', 'Female', 'Fluorescent Antibody Technique', 'Humans', 'Immune Tolerance', 'Immunosuppression', 'Immunosuppressive Agents', 'Male', 'Microtubule-Associated Proteins', 'Neuropeptides', 'Rats', 'Spinal Cord', 'Stem Cell Transplantation... | 21,669,047 | [['C10.228.854.139', 'C10.574.562.250', 'C10.574.950.050', 'C10.668.467.250', 'C18.452.845.800.050'], ['B01.050'], ['G04.346'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['E01.370.225.500.607.512.240', 'E01.370.225.750.551.512.240', 'E05.200.500.607.512.240', 'E05.200.750.551.512.240', 'E05.478.583.375'], ['B01.05... | ['Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Motility study in right sided diverticular disease of the colon. | Intraluminal pressure in the ascending colon of 13 patients with right sided diverticular disease and 10 of normal subjects was studied with catheter-tip transducer inserted through colonoscopes. In the resting state the colonic motility index of patients with diverticular disease was greater than that of the controls.... | ['Adolescent', 'Adult', 'Aged', 'Colon', 'Colonoscopy', 'Diverticulum, Colon', 'Female', 'Gastrointestinal Motility', 'Humans', 'Male', 'Middle Aged', 'Neostigmine', 'Pressure', 'Transducers, Pressure'] | 6,642,277 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['A03.556.124.526.356', 'A03.556.249.249.356'], ['E01.370.372.250.250.200', 'E01.370.388.250.250.250.160', 'E04.210.240.250.160', 'E04.502.250.250.250.160'], ['C06.405.205.282.750.500', 'C23.300.415.500'], ['G10.261.360'], ['B01.050.150.900.649.313.988.400.112.400... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Case Report: First Molecular Diagnosis of Liver Abscesses Due to Fasciola hepatica | We report a case of Fasciola hepatica liver abscesses in a 67-year-old female returning from a trip to Vietnam. She has been suffering from a fever, right abdominal pain for 4 days, and major eosinophilia. Radiologic investigations showed multiple hypodense confluent abscesses in the right lobe of the liver, complicate... | ['Aged', 'Animals', 'Anthelmintics', 'Antibodies, Helminth', 'Factor Xa Inhibitors', 'Fasciola hepatica', 'Fascioliasis', 'Feces', 'France', 'Humans', 'Liver Abscess', 'Rivaroxaban', 'Travel', 'Triclabendazole', 'Vietnam'] | 31,701,866 | [['M01.060.116.100'], ['B01.050'], ['D27.505.954.122.250.075'], ['D12.776.124.486.485.114.185', 'D12.776.124.790.651.114.185', 'D12.776.377.715.548.114.185'], ['D27.505.519.389.745.800.449.500', 'D27.505.954.502.119.500.500'], ['B01.050.500.500.736.715.408.380.420'], ['C01.610.335.865.354', 'C01.610.518.424', 'C06.552.... | ['Named Groups [M]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 |
Solanum glaucophyllum as source of 1,25-dihydroxyvitamin D3. | Vitamin D-deficient rats given an aqueous extract of the South American plant Solanum glaucophyllum accumulate 1,25-dihydroxyvitamin D3 in their blood and intestines at the time they show enhanced intestinal calcium absorption. The identity of the 1,25-dihydroxyvitamin D3 was established by co-chromatography with 1,25-... | ['Animals', 'Biological Assay', 'Chromatography, High Pressure Liquid', 'Dihydroxycholecalciferols', 'Hydroxycholecalciferols', 'Plants', 'Rats', 'Vitamin D Deficiency'] | 856,794 | [['B01.050'], ['E05.091'], ['E05.196.181.400.300'], ['D04.210.500.247.222.159.478.387', 'D04.210.500.247.808.146.478.387', 'D04.210.500.812.768.196.478.387', 'D10.570.938.146.478.387'], ['D04.210.500.247.222.159.478', 'D04.210.500.247.808.146.478', 'D04.210.500.812.768.196.478', 'D10.570.938.146.478'], ['B01.650'], ['B... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Sexual experience reduces neuronal activity in the central part of the medial preoptic nucleus in male rats during sexual behavior. | The medial preoptic area (MPN) plays an important role in the control of male sexual behavior. In rats, the central part of the MPN (MPNc) is sexually dimorphic and contains a sexually dimorphic nucleus composed of neurons expressing calbindin-D28 K (CALB-SDN). Although the functions of the MPNc are not well understood... | ['Animals', 'Ejaculation', 'Male', 'Neurons', 'Preoptic Area', 'Proto-Oncogene Proteins c-fos', 'Sex Characteristics', 'Sexual Behavior', 'Sexual Behavior, Animal'] | 30,170,041 | [['B01.050'], ['G08.686.784.084'], ['A08.675', 'A11.671'], ['A08.186.211.180.497.342.450', 'A08.186.211.200.317.357.342.450'], ['D12.776.260.108.765', 'D12.776.624.664.700.179', 'D12.776.660.760', 'D12.776.930.127.765'], ['G08.686.815'], ['F01.145.802'], ['F01.145.113.252.748']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Increased incorporation of 5-fluorodeoxyuridine into DNA of human T-lymphoblastic cell lines. | Various human leukemoblastoid cell lines in logarithmic growth were incubated for 16 hr with 0.5 microM [3H]fluorodeoxyuridine (FdUrd) and the incorporation of [3H]FdUrd into DNA was measured. T-acute lymphoblastic leukemia (T-ALL) cell lines incorporated 2.4-7.0 times more [3H]FdUrd into newly synthesized DNA than cel... | ['Cell Line', 'DNA Glycosylases', 'DNA, Neoplasm', 'Floxuridine', 'Humans', 'Leukemia, Lymphoid', 'N-Glycosyl Hydrolases', 'Pyrophosphatases', 'Tritium', 'Uracil-DNA Glycosidase'] | 6,151,533 | [['A11.251.210'], ['D08.811.074.249', 'D08.811.277.450.430.099'], ['D13.444.308.425'], ['D03.383.742.680.852.300.350', 'D13.570.230.430.432', 'D13.570.685.852.300.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.337.428', 'C15.604.515.560', 'C20.683.515.528'], ['D08.811.277.450.430'], ['D08.811.277.040... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Platelet-activating factor induces leukotriene C4 synthesis by purified human eosinophils. | Platelet-activating factor, at a concentration of 10 microM, was capable of inducing leukotriene C4 synthesis by eosinophils of healthy donors, i.e. (3.1 +/- 0.3) x 10(6) molecules leukotriene C4/cell (n = 31, mean +/- SEM, cell purity 87 +/- 2%). Reversed-phase high performance liquid chromatography analysis demonstra... | ['Arachidonic Acid', 'Arachidonic Acids', 'Calcimycin', 'Chromatography, High Pressure Liquid', 'Drug Synergism', 'Eosinophils', 'Humans', 'Platelet Activating Factor', 'Radioimmunoassay', 'SRS-A', 'Time Factors', 'Zymosan'] | 3,118,415 | [['D10.251.355.255.100.100', 'D10.251.355.310.166.100'], ['D10.251.355.255.100', 'D10.251.355.310.166'], ['D03.633.100.221.173'], ['E05.196.181.400.300'], ['G07.690.773.968.477'], ['A11.118.637.415.345', 'A11.627.340.345', 'A15.145.229.637.415.345', 'A15.382.490.315.251'], ['B01.050.150.900.649.313.988.400.112.400.400'... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A solution NMR study of the binding kinetics and the internal dynamics of an HIV-1 protease-substrate complex. | NMR studies of the binding of a substrate to an inactive HIV-1 protease construct, containing an active site mutation PR(D25N), are reported. Substrate titration measurements monitored by HSQC spectra and a (15)N-edited NOESY experiment show that the chromogenic substrate analog of the capsid/p2 cleavage site binds to ... | ['HIV Protease', 'Kinetics', 'Magnetic Resonance Spectroscopy', 'Models, Molecular', 'Protein Binding', 'Protein Conformation', 'Solutions', 'Substrate Specificity'] | 12,824,484 | [['D08.811.277.656.074.500.340', 'D08.811.277.656.300.048.340', 'D08.811.277.656.979.500', 'D12.776.964.775.375.545.750', 'D12.776.964.900.500.625'], ['G01.374.661', 'G02.111.490'], ['E05.196.867.519'], ['E05.599.595'], ['G02.111.679', 'G03.808'], ['G02.111.570.820.709'], ['D26.776'], ['G02.111.835']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Characterization, source identification and risk associated with polyaromatic and chlorinated organic contaminants (PAHs, PCBs, PCBzs and OCPs) in the surface sediments of Hooghly estuary, India. | The spatial distribution, source identification and ecotoxicological impact of a group of persistent organic pollutants (POPs: dichlorodiphenyltrichloroethane (DDT), hexachlorocyclohexanes (HCHs), polychlorobiphenyls (PCBs), polychlorobenzenes (PCBzs)), and polyaromatic hydrocarbons (PAHs) were investigated in surface ... | ['Environmental Monitoring', 'Estuaries', 'Geologic Sediments', 'Hydrocarbons, Chlorinated', 'India', 'Pesticides', 'Polycyclic Aromatic Hydrocarbons', 'Rivers', 'Water Pollutants, Chemical'] | 30,639,811 | [['N06.850.460.350.080', 'N06.850.780.375'], ['G01.311.625.540'], ['G01.311.330', 'G16.500.320'], ['D02.455.526.439'], ['Z01.252.245.393'], ['D27.720.031.700', 'D27.888.723'], ['D02.455.426.559.847', 'D04.615'], ['G01.311.750', 'G16.500.275.280.650', 'N06.230.232.650'], ['D27.888.284.903.655']] | ['Health Care [N]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Geographicals [Z]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Effect of seeing tobacco use in films on trying smoking among adolescents: cross sectional study. | OBJECTIVE: To test the hypothesis that greater exposure to smoking in films is associated with trying smoking among adolescents.DESIGN: Cross sectional survey of 4919 schoolchildren aged 9-15 years, and assessment of occurrence of smoking in 601 films.SETTING: Randomly selected middle schools in Vermont and New Hampshi... | ['Adolescent', 'Adolescent Behavior', 'Age Factors', 'Child', 'Cross-Sectional Studies', 'Female', 'Humans', 'Imitative Behavior', 'Male', 'Motion Pictures', 'New Hampshire', 'Odds Ratio', 'Prevalence', 'Psychometrics', 'Risk Factors', 'Smoking', 'Social Environment', 'Television', 'Vermont'] | 11,744,562 | [['M01.060.057'], ['F01.145.022'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.406'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.510'], ['J01.897.280.500.598', 'K01.093.545', 'L01.178.590.500', 'L01.178.820.090.598'], [... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Humanities [K]', 'Information Science [L]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Anthropology, E... | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 |
Fluoroquinolone resistance in Neisseria gonorrhoeae--Colorado and Washington, 1995. | The fluoroquinolones ciprofloxacin and ofloxacin are among the antimicrobial agents recommended by CDC for treating gonorrhea (1). In the United States, decreased susceptibility or resistance of strains of Neisseria gonorrhoeae to the fluoroquinolones has been reported only sporadically, and treatment failure associate... | ['Adult', 'Anti-Infective Agents', 'Colorado', 'Drug Resistance, Microbial', 'Female', 'Fluoroquinolones', 'Gonorrhea', 'Humans', 'Male', 'Neisseria gonorrhoeae', 'Washington'] | 7,565,558 | [['M01.060.116'], ['D27.505.954.122'], ['Z01.107.567.875.760.210'], ['G06.225', 'G07.690.773.984.269'], ['D03.633.100.810.835.322'], ['C01.150.252.400.625.275', 'C01.150.252.734.401', 'C01.221.812.281.401', 'C01.778.281.401', 'C12.294.668.281.401', 'C13.351.500.711.281.401'], ['B01.050.150.900.649.313.988.400.112.400.4... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
The birth and development of sexual medicine: reflections of my personal journey. | INTRODUCTION: The phrase "sexual medicine" has become commonplace, as there is now the International Society for Sexual Medicine, the British Society for Sexual Medicine, the European Academy for Sexual Medicine, and the Journal of Sexual Medicine. The historic origin of the phrase "sexual medicine" is somewhat obscure... | ['Clinical Medicine', 'Europe', 'History, 20th Century', 'Humans', 'Journalism, Medical', 'Periodicals as Topic', 'Sexology', 'Sexual Dysfunction, Physiological', 'Sexual Dysfunctions, Psychological', 'United States'] | 17,498,111 | [['H02.403.200'], ['Z01.542'], ['K01.400.504.968'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.737.498.550'], ['L01.178.682.829.678'], ['F04.096.837'], ['C12.294.644', 'C13.351.500.665'], ['F03.835'], ['Z01.107.567.875']] | ['Disciplines and Occupations [H]', 'Geographicals [Z]', 'Humanities [K]', 'Organisms [B]', 'Information Science [L]', 'Psychiatry and Psychology [F]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 |
A naturally occurring gamma globin gene mutation enhances SP1 binding activity. | Transcription of the human fetal globin genes in erythroid cells is tightly regulated during different stages of development and differentiation. Two naturally occurring mutations 202 base pairs upstream of the duplicated gamma globin genes are associated with incorrectly regulated gamma globin gene gene expression; el... | ['Base Sequence', 'Binding Sites', 'Cell Line', 'DNA, Viral', 'DNA-Binding Proteins', 'Fetal Hemoglobin', 'Gene Expression Regulation', 'Globins', 'Hemoglobinopathies', 'Humans', 'Molecular Sequence Data', 'Mutation', 'Oligonucleotide Probes', 'Regulatory Sequences, Nucleic Acid', 'Simian virus 40', 'Sp1 Transcription ... | 1,688,466 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G02.111.570.120'], ['A11.251.210'], ['D13.444.308.568'], ['D12.776.260'], ['D12.776.124.400.303', 'D12.776.422.316.762.320'], ['G05.308'], ['D12.776.422.316'], ['C15.378.420', 'C16.320.365'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.453.245.667... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Concentration and isolation of DNA from biological fluids by agarose gel isotachophoresis. | Isotachophoresis is an electrophoretic method of separation of charged substances. The method is characterized by a discontinuous buffer system, constant velocity of separated molecules, and the distribution of separated components in the form of narrow concentrated bands located one right after another. As a rule, iso... | ['Buffers', 'DNA', 'DNA, Neoplasm', 'Electrophoresis, Agar Gel', 'Genetic Techniques', 'Humans', 'Neoplasms', 'Nucleic Acids', 'Pancreatic Neoplasms', 'Polymerase Chain Reaction', 'Sepharose'] | 16,312,218 | [['D27.720.470.280'], ['D13.444.308'], ['D13.444.308.425'], ['E05.196.401.153', 'E05.301.300.100'], ['E05.393'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04'], ['D13.444'], ['C04.588.274.761', 'C04.588.322.475', 'C06.301.761', 'C06.689.667', 'C19.344.421'], ['E05.393.620.500'], ['D09.698.813']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Triiodothyronine deiodinating activity in brown adipose tissue after short cold stimulation test in trained and untrained rats. | Interscapular brown adipose tissue (IBAT) activity is controlled by sympathetic nervous system, and factors that influence thermogenesis appear to be centrally connected to the sympathetic outflow to IBAT. Cold exposure produces a rise in BAT temperature, which is associated with an increased thyroid activity, elevated... | ['Adipose Tissue, Brown', 'Animals', 'Body Temperature Regulation', 'Cold Temperature', 'Eating', 'Iodide Peroxidase', 'Male', 'Oxygen Consumption', 'Rats', 'Rats, Sprague-Dawley', 'Thyroxine', 'Triiodothyronine'] | 14,984,316 | [['A10.165.114.322'], ['B01.050'], ['G07.110.232', 'G07.410.421', 'G16.012.500.535'], ['G01.906.595.272', 'G16.500.275.063.725.710.300', 'G16.500.750.775.710.300', 'N06.230.300.100.725.154', 'N06.230.300.100.725.710.300'], ['G07.203.650.283', 'G10.261.330'], ['D08.811.682.732.525'], ['G03.680'], ['B01.050.150.900.649.3... | ['Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
LFCseq: a nonparametric approach for differential expression analysis of RNA-seq data. | BACKGROUND: With the advances in high-throughput DNA sequencing technologies, RNA-seq has rapidly emerged as a powerful tool for the quantitative analysis of gene expression and transcript variant discovery. In comparative experiments, differential expression analysis is commonly performed on RNA-seq data to identify g... | ['Algorithms', 'Cell Line, Tumor', 'Computer Simulation', 'Gene Expression Profiling', 'Gene Expression Regulation, Neoplastic', 'HEK293 Cells', 'Humans', 'Poisson Distribution', 'RNA', 'Sequence Analysis, RNA', 'Software'] | 25,560,842 | [['G17.035', 'L01.224.050'], ['A11.251.210.190', 'A11.251.860.180'], ['L01.224.160'], ['E05.393.332'], ['G05.308.370'], ['A11.251.210.172.750', 'A11.436.334'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.994.750', 'G17.820.750', 'N05.715.360.750.750.620', 'N06.850.520.830.994.750'], ['D13.444.735'], ... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Molecular cloning and chromosomal localization of human 4-beta-galactosyltransferase. | A cDNA clone to human 4-beta-galactosyltransferase (EC 2.4.1.38) was isolated from a human liver lambda gt11 expression library by using a monospecific polyclonal antiserum to affinity-purified bovine enzyme. The authenticity of this cDNA clone has been demonstrated by several criteria. Under conditions of chronic trea... | ['Amino Acid Sequence', 'Base Sequence', 'Chromosome Mapping', 'Chromosomes, Human, Pair 4', 'Cloning, Molecular', 'DNA', 'Galactosyltransferases', 'Gene Expression Regulation', 'Humans', 'Isoproterenol', 'Parotid Gland', 'RNA, Messenger'] | 3,097,639 | [['G02.111.570.060', 'L01.453.245.667.060'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.393.183'], ['A11.284.187.520.300.280.285', 'G05.360.162.520.300.280.285'], ['E05.393.220'], ['D13.444.308'], ['D08.811.913.400.450.400'], ['G05.308'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.033.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Envelope glycoprotein and CD4 independence of vpu-facilitated human immunodeficiency virus type 1 capsid export. | The effect of vpu on the release of human immunodeficiency type 1 capsid proteins was examined in the presence or absence of virus-encoded envelope glycoproteins as well as in cells which constitutively express either the CD4 or CD8 protein. The results show that vpu-mediated facilitated export of capsid proteins from ... | ['Antigens, CD', 'Capsid', 'Codon', 'Genes, Viral', 'Genes, env', 'Genes, vpu', 'HIV-1', 'HeLa Cells', 'Human Immunodeficiency Virus Proteins', 'Humans', 'Kinetics', 'Mutagenesis, Site-Directed', 'Proviruses', 'Restriction Mapping', 'Trans-Activators', 'Transfection', 'Viral Envelope Proteins', 'Viral Regulatory and Ac... | 1,629,967 | [['D23.050.301.264.035', 'D23.101.100.110'], ['A21.249.500.250'], ['D13.444.735.544.355', 'G05.360.335.355', 'G05.360.340.024.340.137.190'], ['G05.360.340.024.340.364.875', 'G05.360.340.358.024.875', 'G05.360.340.358.840.500'], ['G05.360.340.024.340.364.875.172', 'G05.360.340.358.024.875.172', 'G05.360.340.358.840.500.... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Isolation of a cDNA encoding a photoreceptor cell-specific actin-bundling protein: retinal fascin. | We have isolated a novel retina-specific gene, retinal fascin, encoding a new member of actin-bundling protein gene family, from a bovine retina cDNA library. The cDNA encodes a 492 amino acid protein which shows 36-57% amino acid identity with three vertebrate fascins, echinoid fascin and Drosophila singed gene. North... | ['Amino Acid Sequence', 'Animals', 'Base Sequence', 'Carrier Proteins', 'Cattle', 'DNA, Complementary', 'Drosophila', 'Humans', 'In Situ Hybridization', 'Male', 'Mice', 'Microfilament Proteins', 'Molecular Sequence Data', 'Photoreceptor Cells', 'RNA, Messenger', 'Rats', 'Rats, Wistar', 'Retina', 'Sequence Alignment', '... | 9,315,724 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D12.776.157'], ['B01.050.150.900.649.313.500.380.271'], ['D13.444.308.497.220', 'D13.444.600.223.500', 'D27.720.470.530.600.223.260'], ['B01.050.500.131.617.720.500.500.750.310.250'], ['B01.050.150.900... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Nerve conduction studies in lower limb of elite Nepalese football players: an insight into neural adaptations. | BACKGROUND: The study was aimed to assess somatic neural alterations in lower limbs of elite Nepalese football players by comparing their nerve conduction parameters with non-athletic controls.METHODS: Players (N.=27, age 22.74±2.52 yrs.) with excellent cardio-respiratory fitness and presenting no signs of injuries, an... | ['Action Potentials', 'Adaptation, Physiological', 'Adult', 'Electromyography', 'Humans', 'Lower Extremity', 'Male', 'Middle Aged', 'Nepal', 'Neural Conduction', 'Soccer', 'Tibial Nerve'] | 26,842,865 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['G07.025', 'G16.012.500'], ['M01.060.116'], ['E01.370.405.255', 'E01.370.530.255'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A01.378.610'], ['M01.060.116.630'], ['Z01.252.245.674'], ['G07.265.753', 'G11.561.601'], ['I03.450.642.845.800'], ['A08.800.800.... | ['Phenomena and Processes [G]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 |
A theoretical argumentation on the consequences of moral stress. | BACKGROUND: Intensive care units are characterized by heavy workloads, increasing work complexity and ethical concerns related to life-and-death decisions. In the present study, it is assumed that there is a relationship between moral stress, support and competence for nurses in intensive care units.AIM: To analyse and... | ['Adaptation, Psychological', 'Attitude of Health Personnel', 'Burnout, Professional', 'Clinical Competence', 'Conflict, Psychological', 'Cooperative Behavior', 'Critical Care', 'Decision Making', 'Empathy', 'Ethical Theory', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Interprofessional Relations', 'Morals', 'N... | 17,456,175 | [['F01.058'], ['F01.100.050', 'N05.300.100'], ['C24.580.500', 'F01.145.126.990.367.500', 'F02.830.900.333.500'], ['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['F01.658.209'], ['F01.145.813.115'], ['E02.760.190', 'N02.421.585.190'], ['F02.463.785.373'], ['F01.752.355', 'F01.752.543.500.500'], ['K01.752.566.479.118... | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Humanities [K]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Named Groups [M]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
[Histamine concentration in the arterial and venous blood, plasma and basophile leucocytes on patients with chronic obstructive bronchitis and on healthy persons ]. | Patients with chronic obstructive bronchitis (non atopics) show significant increased histamine concentrations in the plasma. In these patients the histamine concentration in the whole blood was also higher. The histamine concentration in the blood reflect primarily the concentration of basophiles. In individual patien... | ['Basophils', 'Blood Gas Analysis', 'Bronchitis', 'Histamine', 'Humans', 'Plethysmography, Whole Body'] | 7,120,876 | [['A11.118.637.415.120', 'A11.627.340.120', 'A15.145.229.637.415.120', 'A15.382.490.315.120'], ['E01.370.225.124.100.100', 'E01.370.386.700.100', 'E05.200.124.100.100'], ['C01.748.099', 'C08.127.446', 'C08.381.495.146', 'C08.730.099'], ['D02.092.211.215.501', 'D02.092.471.440', 'D03.383.129.308.373', 'D23.469.050.300']... | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Molecular mechanisms of tirapazamine (SR 4233, Win 59075)-induced hepatocyte toxicity under low oxygen concentrations. | Previously we showed that tirapazamine (SR 4233, Win 59075) is cytotoxic towards hepatocytes under conditions of hypoxia but not in 10% or 95% oxygen and that bioreduction by DT-diaphorase or cytochrome P450 is not a major pathway. In the present study, we report that tirapazamine is highly cytotoxic to isolated rat he... | ['Animals', 'Antineoplastic Agents', 'Antioxidants', 'Cell Hypoxia', 'Cell Survival', 'Cells, Cultured', 'Cytochrome P-450 CYP2E1', 'Cytochrome P-450 Enzyme Inhibitors', 'Cytochrome P-450 Enzyme System', 'Electron Transport', 'Kinetics', 'Liver', 'Male', 'Mitochondria, Liver', 'NAD(P)H Dehydrogenase (Quinone)', 'Oxidor... | 7,710,944 | [['B01.050'], ['D27.505.954.248'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['G03.197.300', 'G04.270.300'], ['G04.346'], ['A11.251'], ['D08.244.453.491.375', 'D08.811.682.662.582.338', 'D08.811.682.690.708.170.450.375', 'D12.776.422.220.453.491.375'], ['D27.505.389.500', 'D27.505.519.389.335'], ['... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Primary atrial heart tumors--a review of 21 cases]. | Between 1978 and 1986, atrial heart tumors were found in 21 of our patients, all of them subsequently underwent surgery. Pathological-histological examination in 20 patients confirmed the diagnosis of a myxoma; the one remaining case was a female patient with primary cardiogenic osteosarcoma. Of the 20 patients, 15 (75... | ['Adult', 'Aged', 'Echocardiography', 'Female', 'Heart Atria', 'Heart Neoplasms', 'Heart Valve Diseases', 'Heart Valve Prosthesis', 'Heart Valves', 'Humans', 'Male', 'Middle Aged', 'Myxoma', 'Osteosarcoma', 'Postoperative Complications'] | 3,213,145 | [['M01.060.116'], ['M01.060.116.100'], ['E01.370.350.130.750', 'E01.370.350.850.220', 'E01.370.370.380.220'], ['A07.541.358'], ['C04.588.894.309', 'C14.280.459'], ['C14.280.484'], ['E07.695.310'], ['A07.541.510'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C04.557.450.565.550'], ['C04.557.4... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Factors associated with prior engagement in high-risk sexual behaviours among adolescents (10-19 years) in a pastoralist post-conflict community, Karamoja sub-region, North eastern Uganda. | BACKGROUND: Adolescent sexual risky behaviours continue to be significant drivers of the HIV epidemic globally. The objective of this study was to determine factors associated with prior engagement in high-risk sexual behaviours among adolescents (10-19 years) in Karamoja sub-region, a pastoralist and post-conflict com... | ['Adolescent', 'Adolescent Behavior', 'Agriculture', 'Armed Conflicts', 'Child', 'Condoms', 'Cross-Sectional Studies', 'Female', 'HIV Infections', 'Humans', 'Male', 'Risk Factors', 'Risk-Taking', 'Sexual Behavior', 'Sexual Partners', 'Surveys and Questionnaires', 'Uganda', 'Young Adult'] | 31,366,339 | [['M01.060.057'], ['F01.145.022'], ['J01.040'], ['I01.880.735.950.250'], ['M01.060.406'], ['E07.190.270.150'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['B01.... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Technology, Industry, and Agriculture [J]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
Molecular mechanism for muscarinic M1 | KEY POINTS: The muscarinic acetylcholine receptor (mAChR)-mediated increase in excitability in rat adrenal medullary cells is at least in part due to inhibition of TWIK (tandem of P domains in a weak inwardly rectifying K+ channel)-related acid-sensitive K+ (TASK)1 channels. In this study we focused on the molecular me... | ['Adrenal Medulla', 'Animals', 'Cells, Cultured', 'Endocytosis', 'Male', 'Nerve Tissue Proteins', 'PC12 Cells', 'Potassium Channels, Tandem Pore Domain', 'Protein Kinase C', 'Rats', 'Rats, Wistar', 'Receptors, Muscarinic', 'Type C Phospholipases', 'src-Family Kinases'] | 28,944,482 | [['A06.300.071.265'], ['B01.050'], ['A11.251'], ['G04.417'], ['D12.776.631'], ['A11.251.210.190.750', 'A11.251.860.180.750', 'A11.299.500'], ['D12.776.157.530.400.600.850', 'D12.776.543.550.450.750.850', 'D12.776.543.585.400.750.850'], ['D08.811.913.696.620.682.700.725'], ['B01.050.150.900.649.313.992.635.505.700'], ['... | ['Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A quantitative morphology of nucleoli of erythroblasts in the mouse spleen: an electron microscopic study. | Nucleolar changes during the differentiation of erythroblasts in the mouse spleen were examined quantitatively by electron microscopy. On the basis of a three-dimensional nuclear analysis, as reported previously, the erythroblasts could be classified into four types: small (S), medium (M), large (L) and extra-large (EL... | ['Aging', 'Animals', 'Animals, Newborn', 'Cell Differentiation', 'Cell Nucleolus', 'Erythroblasts', 'Erythrocytes', 'Female', 'Mice', 'Mice, Inbred Strains', 'Microscopy, Electron', 'Spleen'] | 6,870,491 | [['G07.345.124'], ['B01.050'], ['B01.050.050.282'], ['G04.152'], ['A11.284.430.106.279.345.175'], ['A11.148.378.590.837.250.200', 'A11.443.240.497.200', 'A15.378.316.378.590.837.250.200'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520', 'B01.05... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The tyrphostin AG1024 accelerates the degradation of phosphorylated forms of retinoblastoma protein (pRb) and restores pRb tumor suppressive function in melanoma cells. | Constitutive cell surface receptor kinase signaling and persistent phosphorylation/inactivation of the retinoblastoma (pRb) family of proteins (pRb, p107 and p130, known as pocket proteins) have been implicated in conferring uncontrolled growth to melanoma cells. However, the signals linking receptor kinase activity to... | ['Animals', 'Cell Cycle Proteins', 'Cell Division', 'Cyclin-Dependent Kinases', 'DNA-Binding Proteins', 'E2F Transcription Factors', 'E2F1 Transcription Factor', 'E2F3 Transcription Factor', 'Humans', 'MAP Kinase Signaling System', 'Melanocytes', 'Melanoma', 'Mice', 'Mitogen-Activated Protein Kinase 1', 'Phosphorylatio... | 12,649,208 | [['B01.050'], ['D12.776.167'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['D08.811.913.696.620.682.700.646.500', 'D12.644.360.250', 'D12.776.167.200', 'D12.776.476.250'], ['D12.776.260'], ['D12.776.930.211'], ['D12.644.360.024.328.049', 'D12.776.157.057.158.049', 'D12.776.476.024.420.049... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A system for analysis of arterial blood pressure waveforms in humans. | Recent developments in arterial hemodynamics have indicated that the human arterial pressure waveform contains more information than is available from conventional sphygmomanometry. This information includes indices describing left ventricular systolic function and arterial properties. A cheap and reliable system was d... | ['Aged', 'Algorithms', 'Ambulatory Care', 'Aorta', 'Arteries', 'Blood Pressure', 'Blood Pressure Determination', 'Cardiac Output', 'Computer Systems', 'Critical Care', 'Database Management Systems', 'Heart Diseases', 'Heart Rate', 'Hemodynamics', 'Humans', 'Information Storage and Retrieval', 'Online Systems', 'Reprodu... | 9,281,331 | [['M01.060.116.100'], ['G17.035', 'L01.224.050'], ['E02.760.106', 'N02.421.585.106'], ['A07.015.114.056'], ['A07.015.114'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E01.370.370.140', 'E01.370.600.100'], ['E01.370.370.380.150', 'G09.330.380.124'], ['L01.224.230'], ['E02.760.190', 'N02.421.585.190'], ['L01.224.068',... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Intermediates in the biosynthesis of double-stranded ribonucleic acids of bacteriophage phi 6. | Pseudomonas phaseolicola infected with bacteriophage phi 6 synthesized all three viral double-stranded RNA segments, three single-stranded RNAs, and three replicative intermediate-like RNAs in the presence of rifampin. The single-stranded RNA intermediates sedimented and electrophoresed along with melted viral double-s... | ['Bacteriophages', 'Chloramphenicol', 'Depression, Chemical', 'Molecular Weight', 'Nucleic Acid Hybridization', 'Pseudomonas', 'RNA, Viral', 'Rifampin'] | 1,055,383 | [['B04.123'], ['D02.033.455.706.300', 'D02.455.426.559.389.565.175', 'D02.640.529.175'], ['G07.690.773.750'], ['G02.494'], ['E05.393.661', 'G02.111.611'], ['B03.440.400.425.625.625', 'B03.660.250.580.590'], ['D13.444.735.828'], ['D03.633.400.811.700', 'D04.345.295.750.700']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Aminopeptidase N is involved in cell motility and angiogenesis: its clinical significance in human colon cancer. | BACKGROUND & AIMS: The molecular basis of cell motility is highly complex and is controlled by a number of molecular systems, whereas angiogenesis is an important biological component of tumor progression. The aims of this study were to investigate the possible involvement of proteins at the cell surface in controlling... | ['Animals', 'Antibodies, Monoclonal', 'Antigens, Neoplasm', 'B-Lymphocytes', 'CD13 Antigens', 'Capillaries', 'Cell Division', 'Cell Movement', 'Colonic Neoplasms', 'DNA, Complementary', 'Disease-Free Survival', 'Epitopes', 'Fibrosarcoma', 'Gene Expression Regulation, Enzymologic', 'Gene Expression Regulation, Neoplasti... | 11,832,452 | [['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D23.050.285'], ['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['D08.811.277.656.350.100.160', 'D08.811.277.656.350.555.100', 'D08.811.2... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
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