Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Brainstem anesthesia presenting as contralateral third nerve palsy following peribulbar anesthesia for cataract surgery. | Brainstem anesthesia is a serious complication that has been reported to occur more commonly with retrobulbar anesthesia compared to peribulbar anesthesia. We herein report a case of contralateral third nerve palsy following administration of peribulbar anesthesia for cataract surgery. Two hours after the surgery, the ... | ['Anesthesia, Conduction', 'Brain Stem', 'Cataract Extraction', 'Humans', 'Male', 'Middle Aged', 'Nerve Block', 'Oculomotor Nerve Diseases'] | 24,148,744 | [['E03.155.086'], ['A08.186.211.132'], ['E04.540.825.249'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E03.155.086.711', 'E04.525.210.550'], ['C10.292.562.700', 'C11.590.436']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Named Groups [M]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Cancer patients' expectations when undergoing extensive molecular diagnostics-A qualitative study. | OBJECTIVE: Precision cancer medicine (PCM) aims at identifying tumor-driving molecular characteristics to improve therapy. Despite early successes for some cancers, the approach faces manifold challenges. Patients undergoing extensive molecular diagnostics (MD) may hope for personal benefit, although chances are small.... | ['Adult', 'Attitude of Health Personnel', 'Female', 'Humans', 'Male', 'Middle Aged', 'Motivation', 'Neoplasm Staging', 'Neoplasms', 'Oncologists', 'Pathology, Molecular', 'Physician-Patient Relations', 'Qualitative Research', 'Surveys and Questionnaires'] | 31,713,281 | [['M01.060.116'], ['F01.100.050', 'N05.300.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['F01.658', 'F01.752.543.500.750'], ['E01.789.625'], ['C04'], ['M01.526.485.810.699', 'N02.360.810.699'], ['H01.158.201.636.475.750', 'H01.158.273.343.595.475.750', 'H01.181.122.650.475.680', 'H02.403... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Memory in Trait Macroevolution. | The history of a trait within a lineage may influence its future evolutionary trajectory, but macroevolutionary theory of this process is not well developed. For example, consider the simplified binary trait of living in cave versus surface habitat. The longer a species has been cave dwelling, the more accumulated loss... | ['Biological Evolution', 'Markov Chains', 'Models, Theoretical', 'Phenotype', 'Phylogeny', 'Time Factors'] | 32,017,618 | [['G05.045', 'G16.075'], ['E05.318.740.600.500', 'E05.318.740.996.500', 'G17.830.500', 'N05.715.360.750.625.500', 'N05.715.360.750.770.500', 'N06.850.520.830.600.500', 'N06.850.520.830.996.500'], ['E05.599'], ['G05.695'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['G01.910.857']] | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Information Science [L]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Assembly of a processive messenger RNA polyadenylation complex. | Polyadenylation of mRNA precursors by poly(A) polymerase depends on two specificity factors and their recognition sequences. These are cleavage and polyadenylation specificity factor (CPSF), recognizing the polyadenylation signal AAUAAA, and poly(A) binding protein II (PAB II), interacting with the growing poly(A) tail... | ['Adenosine Triphosphate', 'Carrier Proteins', 'Hydrolysis', 'Poly A', 'Poly(A)-Binding Proteins', 'Polynucleotide Adenylyltransferase', 'RNA Processing, Post-Transcriptional', 'RNA, Messenger', 'RNA-Binding Proteins', 'Substrate Specificity', 'mRNA Cleavage and Polyadenylation Factors'] | 8,440,247 | [['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['D12.776.157'], ['G02.380'], ['D13.695.578.550.500'], ['D12.776.157.725.452', 'D12.776.664.962.452'], ['D08.811.913.696.445.650'], ['G02.111.760', 'G03.839', 'G05.308.700'], ['D13.444.735.544'], ['D12.776.157.725', 'D12.776.664.962'], ['G0... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
TASK-1, a two-pore domain K+ channel, is modulated by multiple neurotransmitters in motoneurons. | Inhibition of "leak" potassium (K+) channels is a widespread CNS mechanism by which transmitters induce slow excitation. We show that TASK-1, a two pore domain K+ channel, provides a prominent leak K+ current and target for neurotransmitter modulation in hypoglossal motoneurons (HMs). TASK-1 mRNA is present at high lev... | ['Acids', 'Animals', 'Animals, Newborn', 'Cell Line', 'Electric Conductivity', 'Gene Expression', 'Glutamic Acid', 'Humans', 'Hydrogen-Ion Concentration', 'Hypoglossal Nerve', 'Kidney', 'Membrane Potentials', 'Motor Neurons', 'Nerve Tissue Proteins', 'Neurotransmitter Agents', 'Norepinephrine', 'Patch-Clamp Techniques'... | 10,719,894 | [['D01.029'], ['B01.050'], ['B01.050.050.282'], ['A11.251.210'], ['G01.358.500.249.277'], ['G05.297'], ['D12.125.067.625.349', 'D12.125.119.409.349', 'D12.125.427.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.300'], ['A08.800.800.120.330'], ['A05.810.453'], ['G01.154.535', 'G04.580', 'G07.265.675', 'G11... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Astragaloside attenuates myocardial injury in a rat model of acute myocardial infarction by upregulating hypoxia inducible factor‑1á and Notch1/Jagged1 signaling. | The present study aimed to investigate the mechanisms underlying the cardioprotective effect of Astragaloside against myocardial injury following myocardial infarction (MI) in a rat model. Male Wistar rats were subjected to left anterior descending branch ligation. The rats that survived 24 h (n=18) were randomly and e... | ['Animals', 'Cardiotonic Agents', 'Disease Models, Animal', 'Gene Expression Regulation', 'Hypoxia-Inducible Factor 1, alpha Subunit', 'Jagged-1 Protein', 'Male', 'Myocardial Infarction', 'Myocardium', 'Rats', 'Receptor, Notch1', 'Saponins', 'Signal Transduction'] | 28,487,976 | [['B01.050'], ['D27.505.954.411.222', 'D27.720.799.080'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['G05.308'], ['D12.776.260.103.625.750', 'D12.776.930.125.625.750'], ['D12.644.276.930.500', 'D12.776.157.125.797.500', 'D12.776.543.800.500', 'D23.529.930.500'], ['C14.280.647.500', 'C14.907.585.500', 'C23.550.513.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Geographic disparities in donor lung supply and lung transplant waitlist outcomes: A cohort study. | Despite the Final Rule mandate for equitable organ allocation in the United States, geographic disparities exist in donor lung allocation, with the majority of donor lungs being allocated locally to lower-priority candidates. We conducted a retrospective cohort study of 19 622 lung transplant candidates waitlisted betw... | ['Female', 'Geography', 'Humans', 'Lung Transplantation', 'Male', 'Middle Aged', 'Retrospective Studies', 'Tissue Donors', 'Waiting Lists'] | 29,266,733 | [['H01.277.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.928.600.495', 'E04.936.450.495'], ['M01.060.116.630'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.520.450.500.500.500', 'N06.850.520.450.500.750.825'], ['M01.898'],... | ['Disciplines and Occupations [H]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Automated detection of optic disk in retinal fundus images using intuitionistic fuzzy histon segmentation. | The human eye is one of the most sophisticated organs, with perfectly interrelated retina, pupil, iris cornea, lens, and optic nerve. Automatic retinal image analysis is emerging as an important screening tool for early detection of eye diseases. Uncontrolled diabetic retinopathy (DR) and glaucoma may lead to blindness... | ['Adult', 'Aged', 'Aged, 80 and over', 'Artificial Intelligence', 'Diabetic Retinopathy', 'Female', 'Fluorescein Angiography', 'Fuzzy Logic', 'Glaucoma', 'Humans', 'Image Interpretation, Computer-Assisted', 'Male', 'Middle Aged', 'Optic Disk', 'Pattern Recognition, Automated', 'Reproducibility of Results', 'Retinoscopy... | 23,516,954 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['G17.035.250', 'L01.224.050.375'], ['C11.768.257', 'C14.907.320.382', 'C19.246.099.500.382'], ['E01.370.370.050.350', 'E01.370.380.250'], ['E05.599.250', 'K01.752.448.250', 'L01.224.050.375.250'], ['C11.525.381'], ['B01.050.150.900.649.313.988.400.112.400... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Humanities [K]', 'Organisms [B]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
A clinicopathologic study of tuberculous epididymo-orchitis in Thailand. | Tuberculous epididymo-orchitis is an uncommon disease caused by Mycobacterium tuberculosis of the testis and epididymis. We reviewed 25 cases of tuberculous epididymo-orchitis, diagnosed at the Faculty of Medicine Ramathibodi Hospital, Mahidol University between July 2000 and June 2010. The mean age at diagnosis was 54... | ['Adult', 'Aged', 'Aged, 80 and over', 'Epididymis', 'HIV Infections', 'Humans', 'Male', 'Middle Aged', 'Retrospective Studies', 'Testicular Diseases', 'Thailand', 'Tuberculosis, Male Genital', 'Tuberculosis, Pulmonary'] | 23,077,818 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['A05.360.444.371'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.372.500.500.500', 'E05.318.372.... | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
An integratable microfluidic cartridge for forensic swab samples lysis. | Fully automated rapid forensic DNA analysis requires integrating several multistep processes onto a single microfluidic platform, including substrate lysis, extraction of DNA from the released lysate solution, multiplexed PCR amplification of STR loci, separation of PCR products by capillary electrophoresis, and analys... | ['Feasibility Studies', 'Forensic Genetics', 'Microfluidics', 'Microsatellite Repeats', 'Polymerase Chain Reaction'] | 24,315,603 | [['E05.318.372.550', 'E05.337.675', 'N05.715.360.330.550', 'N06.850.520.450.550'], ['H02.403.330.149', 'I01.198.780.937.441'], ['E05.830.666', 'H01.671.808.500', 'J01.897.520.500.500'], ['G02.111.570.080.708.800.500', 'G05.360.080.708.800.500', 'G05.360.340.024.850.500'], ['E05.393.620.500']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 |
Measurement of salivary thiocyanate during the process of smoking cessation. | The changes in salivary thiocyanate (SCN) following smoking cessation were determined for 70 people recruited from community-based smoking cessation programs. Data collected over 3 months following cessation showed a half value of 5 days for abstainers, a strong linear relationship between SCN level and number of days ... | ['Humans', 'Metabolic Clearance Rate', 'Patient Compliance', 'Saliva', 'Smoking Cessation', 'Thiocyanates'] | 2,136,104 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.843', 'E05.200.843', 'G03.490', 'G07.690.595', 'G07.690.725.513'], ['F01.100.150.750.500.600', 'F01.145.488.887.500.600', 'N05.300.150.800.500.600'], ['A12.200.666'], ['F01.145.488.732'], ['D02.262.775', 'D02.886.728']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
PatMatch: a program for finding patterns in peptide and nucleotide sequences. | Here, we present PatMatch, an efficient, web-based pattern-matching program that enables searches for short nucleotide or peptide sequences such as cis-elements in nucleotide sequences or small domains and motifs in protein sequences. The program can be used to find matches to a user-specified sequence pattern that can... | ['Arabidopsis', 'Arabidopsis Proteins', 'DNA, Plant', 'Internet', 'Peptides', 'Sequence Analysis, DNA', 'Sequence Analysis, Protein', 'Software', 'User-Computer Interface'] | 15,980,466 | [['B01.650.940.800.575.912.250.157.100'], ['D12.776.765.149'], ['D13.444.308.435'], ['L01.224.230.110.500'], ['D12.644'], ['E05.393.760.700'], ['E05.393.760.705'], ['L01.224.900'], ['L01.224.900.910']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Subunits of the Pyruvate Dehydrogenase Cluster of Mycoplasma pneumoniae Are Surface-Displayed Proteins that Bind and Activate Human Plasminogen. | The dual role of glycolytic enzymes in cytosol-located metabolic processes and in cell surface-mediated functions with an influence on virulence is described for various micro-organisms. Cell wall-less bacteria of the class Mollicutes including the common human pathogen Mycoplasma pneumoniae possess a reduced genome li... | ['Adhesins, Bacterial', 'Animals', 'Bacterial Proteins', 'Cell Line, Tumor', 'Cell Membrane', 'Escherichia coli', 'Guinea Pigs', 'HeLa Cells', 'Humans', 'Membrane Proteins', 'Mycoplasma pneumoniae', 'Plasminogen', 'Protein Binding', 'Protein Subunits', 'Pyruvate Dehydrogenase Complex', 'Virulence', 'Virulence Factors'] | 25,978,044 | [['D12.776.097.120.050', 'D12.776.543.100.050', 'D23.050.161.050'], ['B01.050'], ['D12.776.097'], ['A11.251.210.190', 'A11.251.860.180'], ['A11.284.149'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['B01.050.150.900.649.313.992.550'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'], ['B01.050... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A high-throughput assay for phosphoprotein-specific phosphatase activity in cellular extracts. | Protein phosphatases undo the post-translational modifications of kinase-signaling networks, but phosphatase activation in cells is difficult to measure and interpret. Here, we report the design of a quantitative and high-throughput assay platform for monitoring cellular phosphatase activity toward specific phosphoprot... | ['Animals', 'Blotting, Western', 'Cell Extracts', 'Dual-Specificity Phosphatases', 'Enzyme Activation', 'Enzyme Assays', 'Enzyme-Linked Immunosorbent Assay', 'Epidermal Growth Factor', 'HT29 Cells', 'Humans', 'Interferon-gamma', 'Mice', 'Mitogen-Activated Protein Kinase Phosphatases', 'Mitogen-Activated Protein Kinases... | 23,233,447 | [['B01.050'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['D20.777.162'], ['D08.811.277.352.650.625.225', 'D08.811.277.352.650.775.250', 'D08.811.641.755', 'D12.644.360.268', 'D12.776.476.268'], ['G02.111.263', 'G03.328'], ['E05.196.427'], ['E05.478.566.350.170'... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Preparation and biological evaluation of metronidazole derivatives with monoterpenes and eugenol. | Two series of metronidazole derivatives (ester derivatives and ether derivatives) were prepared reacting metronidazole and its acetic acid oxidized form with menthol, thymol, carvacrol, and eugenol. Both series of compounds were tested in vitro against two strains of Helicobacter pylori (the ATCC 26695 and P12), and on... | ['Anti-Bacterial Agents', 'Cell Line', 'Cell Survival', 'Clostridium perfringens', 'Eugenol', 'Helicobacter pylori', 'Humans', 'Metronidazole', 'Microbial Sensitivity Tests', 'Monoterpenes'] | 30,022,596 | [['D27.505.954.122.085'], ['A11.251.210'], ['G04.346'], ['B03.300.390.400.200.575', 'B03.353.625.375.500.575', 'B03.510.415.400.200.575'], ['D02.241.223.200.054.500'], ['B03.440.500.550', 'B03.660.150.235.500.250.550'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.640.672.500', 'D03.383.129.308.658.500'], ['E... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Gabapentin in late-onset poststroke seizures. | Stroke is a frequent cause of epileptic seizures (ES) in adults. The authors evaluated the long-term efficacy and tolerability of gabapentin (900 to 1,800 mg/day) in 71 patients with a first poststroke late ES during a mean follow-up time of 30 months. ES recurred in 18.3% of the patients and side effects were noted in... | ['Acetates', 'Aged', 'Amines', 'Anticonvulsants', 'Cyclohexanecarboxylic Acids', 'Dose-Response Relationship, Drug', 'Female', 'Follow-Up Studies', 'Gabapentin', 'Humans', 'Male', 'Middle Aged', 'Prospective Studies', 'Recurrence', 'Seizures', 'Stroke', 'gamma-Aminobutyric Acid'] | 12,499,501 | [['D02.241.081.018', 'D10.251.400.045'], ['M01.060.116.100'], ['D02.092'], ['D27.505.954.427.080'], ['D02.241.223.268', 'D02.455.426.392.368.367.218'], ['G07.690.773.875', 'G07.690.936.500'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['D02.092.521', 'D02.241.081.114.500.... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A multicentre observational study of inter-hospital transfer for post-resuscitation care after out-of-hospital cardiac arrest. | AIM: To provide therapeutic hypothermia (TH) to survivors after out-of-hospital cardiac arrest (OHCA), inter-hospital transfers (IHT) are frequently required. The safety of IHT remains controversial. The aim of this study was to investigate whether the effect of TH on brain recovery after OHCA differs between IHT and d... | ['Adult', 'Aged', 'Cardiopulmonary Resuscitation', 'Case-Control Studies', 'Emergency Medical Services', 'Female', 'Humans', 'Hypothermia, Induced', 'Logistic Models', 'Male', 'Middle Aged', 'Odds Ratio', 'Out-of-Hospital Cardiac Arrest', 'Patient Transfer', 'Prospective Studies', 'Recovery of Function', 'Statistics, N... | 27,591,054 | [['M01.060.116'], ['M01.060.116.100'], ['E02.365.647.110'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['N02.421.297'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.258.750'], ['E05.318.740.500.525', 'E05.318.740.600.800.450', 'E05.318.740.750.450', 'E05.599.835.875', 'N05.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Incident Hearing Loss and Comorbidity: A Longitudinal Administrative Claims Study. | Importance: Because hearing loss is highly prevalent and treatable, determining its association with morbidity has major public health implications for disease prevention and the maintenance of health in adults with hearing loss.Objective: To investigate the association between the diagnosis of incident hearing loss an... | ['Aged', 'Aged, 80 and over', 'Case-Control Studies', 'Comorbidity', 'Databases, Factual', 'Female', 'Follow-Up Studies', 'Hearing Loss', 'Humans', 'Incidence', 'Male', 'Middle Aged', 'Propensity Score', 'Retrospective Studies', 'United States'] | 30,419,134 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['N05.715.350.225', 'N06.850.490.687'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['C09.218.4... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Information Science [L]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
Dye penetration in dry and water-filled gaps along root fillings. | AIM: The aim of this study was to investigate the influence of hydration in voids along root fillings on methylene blue penetration.METHODOLOGY: A total of 80 human root canals were prepared using a step-back technique and filled with a zinc oxide based sealer and gutta-percha. Leakage along the fillings was measured b... | ['Air', 'Coloring Agents', 'Dental Leakage', 'Dental Pulp Cavity', 'Gutta-Percha', 'Humans', 'Immersion', 'Methylene Blue', 'Rheology', 'Root Canal Filling Materials', 'Root Canal Preparation', 'Statistics as Topic', 'Surface Properties', 'Surface Tension', 'Water', 'Zinc Oxide', 'Zinc Oxide-Eugenol Cement'] | 11,307,261 | [['G16.500.275.063.150', 'N06.230.300.100.150'], ['D27.720.233'], ['C07.793.221'], ['A14.549.167.900.265'], ['D20.215.721.061', 'D25.339.859.495', 'D25.720.327.840.119', 'J01.637.051.339.859.495'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.466'], ['D02.886.369.517', 'D03.633.300.783.517'], ['E05.830', 'H01... | ['Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 |
Neurologic injury in isolated sulfite oxidase deficiency. | BACKGROUND: We review clinical, neuroimaging, and genetic information on six individuals with isolated sulfite oxidase deficiency (ISOD).METHODS: All patients were examined, and clinical records, biochemistry, neuroimaging, and sulfite oxidase gene (SUOX) sequencing were reviewed.RESULTS: Data was available on six indi... | ['Amino Acid Metabolism, Inborn Errors', 'Child', 'Child, Preschool', 'Female', 'Humans', 'Infant', 'Male', 'Microcephaly', 'Pedigree', 'Sulfite Oxidase'] | 24,384,336 | [['C16.320.565.100', 'C18.452.648.100'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['C05.660.207.620', 'C10.500.507.400.500', 'C16.131.621.207.620', 'C16.131.666.507.400.500'], ['E05.393.673'], ['D08.811.682.667.249']] | ['Diseases [C]', 'Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Comparison study on phosphorus removal between single-stage oxic process and anaerobic/aerobic process]. | To compare the efficiency of phosphorus removal between anaerobic/aerobic process (SBR1) and single-stage oxic process (SBR2), two SBRs were conducted using acetate as the sole carbon source which is the most extensive substrate in municipal wastewater. The results obtained from three months experiment showed that the ... | ['Aerobiosis', 'Anaerobiosis', 'Bacteria', 'Biodegradation, Environmental', 'Bioreactors', 'Phosphorus', 'Waste Disposal, Fluid', 'Water Pollutants, Chemical'] | 22,295,638 | [['G02.111.017', 'G03.049'], ['G02.111.062', 'G03.078'], ['B03'], ['N06.230.080.600.500', 'N06.850.460.375.500'], ['E07.115', 'J01.897.120.115'], ['D01.268.666'], ['N06.850.780.200.800.800.890', 'N06.850.860.510.900.600.900'], ['D27.888.284.903.655']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Evidence for aberrant activation of the interleukin-2 autocrine loop by HTLV-1-encoded p40x and T3/Ti complex triggering. | In this study we provide evidence that distinct DNA sequences within the 5'-flanking regions of the genes for interleukin-2 (IL-2) and its receptor (IL-2R) are involved in human T-cell-specific activation of transcription by p40x, a product of human T cell leukemia virus type I (HTLV-1). The same DNA sequences appear t... | ['Cell Line', 'Concanavalin A', 'Deltaretrovirus', 'Humans', 'Interleukin-2', 'Lymphocyte Activation', 'Phytohemagglutinins', 'Receptors, Immunologic', 'Receptors, Interleukin-2', 'T-Lymphocytes', 'Transcription, Genetic', 'Viral Proteins'] | 3,026,643 | [['A11.251.210'], ['D12.776.503.499.500', 'D12.776.765.678.500'], ['B04.613.807.200', 'B04.820.650.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.465.021', 'D12.644.276.374.480.372', 'D12.776.467.374.465.021', 'D12.776.467.374.480.372', 'D23.529.374.465.155', 'D23.529.374.480.372'], ['E01.370... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effect of maternal use of chewing gums containing xylitol, chlorhexidine or fluoride on mutans streptococci colonization in the mothers' infant children. | PURPOSE: The aim was to evaluate the effect of maternal use of chewing gums containing xylitol, chlorhexidine/xylitol or fluoride on the prevalence of mutans streptococci (MS) in the mothers' 18-month-old offsprings.MATERIALS AND METHODS: After screening 416 women with newborn babies, 173 mothers with high counts of sa... | ['Adolescent', 'Adult', 'Anti-Infective Agents, Local', 'Cariostatic Agents', 'Chewing Gum', 'Chlorhexidine', 'Colony Count, Microbial', 'Dental Caries', 'Female', 'Fluorides', 'Humans', 'Infant', 'Infectious Disease Transmission, Vertical', 'Male', 'Mother-Child Relations', 'Mothers', 'Mouth', 'Saliva', 'Streptococcus... | 15,643,749 | [['M01.060.057'], ['M01.060.116'], ['D27.505.954.122.187'], ['D25.223', 'D27.505.696.706.222', 'D27.720.102.223', 'D27.720.799.113', 'J01.637.051.223'], ['D05.750.078.739.249', 'D09.698.700.249', 'D20.215.721.249.249', 'G07.203.300.140.200', 'J02.500.140.200'], ['D02.078.370.141.100'], ['E01.370.225.875.220', 'E05.200.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, an... | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 |
Alanine transaminase levels in the year before pregnancy predict the risk of hepatitis C virus vertical transmission. | Vertical transmission is the most common route of hepatitis C virus (HCV) infection in children. Transmission risk factors have been described, but most risk factors can only be evaluated using expensive laboratory exams. The aim of the present study was to evaluate whether maternal alanine transaminase (ALT) levels be... | ['Alanine Transaminase', 'Case-Control Studies', 'Female', 'Hepatitis A Antibodies', 'Hepatitis C', 'Humans', 'Infant, Newborn', 'Infectious Disease Transmission, Vertical', 'Pregnancy', 'Pregnancy Complications, Infectious', 'RNA, Viral', 'Risk Factors', 'Time Factors'] | 16,721,858 | [['D08.811.913.477.700.100'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['D12.776.124.486.485.114.254.450.251', 'D12.776.124.790.651.114.254.450.251', 'D12.776.377.715.548.114.254.450.251'], ['C01.221.250.750', 'C01.925.440.440', 'C01.925.782.350.350', 'C06.552.380.705.440'], ['B01.... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Indian hedgehog signaling promotes chondrocyte differentiation in enchondral ossification in human cervical ossification of the posterior longitudinal ligament. | STUDY DESIGN: Histological, immunohistochemical, and immunoblot analyses of the expression of Indian hedgehog (Ihh) signaling in human cervical ossification of the posterior longitudinal ligament (OPLL).OBJECTIVE: To examine the hypothesis that Ihh signaling in correlation with Sox9 and parathyroid-related peptide horm... | ['Adult', 'Aged', 'Aged, 80 and over', 'Cell Differentiation', 'Cervical Vertebrae', 'Chondrocytes', 'Female', 'Hedgehog Proteins', 'Humans', 'Immunoblotting', 'Immunohistochemistry', 'Male', 'Microscopy, Electron, Transmission', 'Middle Aged', 'Ossification of Posterior Longitudinal Ligament', 'Osteogenesis', 'Parathy... | 23,883,825 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['G04.152'], ['A02.835.232.834.151'], ['A11.329.171'], ['D12.644.276.671', 'D12.776.467.671', 'D23.529.671'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.478.566.320', 'E05.601.470.320'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Giant multilocular prostatic cystadenoma: a distinctive lesion of the retroperitoneum in men. A report of two cases. | Two examples of large, multiloculated, cystic tumors that arose within the pelvis in men of 28 and 37 years of age are described. The tumors were composed of glands and cysts lined by prostatic-type epithelium lying in a hypocellular fibrous stroma. The prostatic nature of the lesions was confirmed by immunohistochemic... | ['Adult', 'Cystadenoma', 'Humans', 'Male', 'Prostatic Neoplasms', 'Retroperitoneal Neoplasms'] | 1,989,460 | [['M01.060.116'], ['C04.557.470.035.320', 'C04.557.470.590.485'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.945.440.770', 'C12.294.260.750', 'C12.294.565.625', 'C12.758.409.750'], ['C04.588.033.731']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Human choriogonadotropin-induced desensitization of granulosa-cell adenylate cyclase to gonadotropins and loss of LH/hCG receptor. | Immature female rats that had been primed with pregnant-mare serum gonadotropin (PMSG) were injected intravenously with various doses of human choriogonadotropin (hCG) for the investigation of the relationship between adenylate cyclase activities and the concentrations of LH/hCG receptor in luteinizing granulosa cells.... | ['Adenylyl Cyclases', 'Animals', 'Chorionic Gonadotropin', 'Drug Tolerance', 'Female', 'Follicle Stimulating Hormone', 'Gonadotropins', 'Granulosa Cells', 'Humans', 'Kinetics', 'Luteinizing Hormone', 'Rats', 'Receptors, Cell Surface', 'Receptors, LH'] | 6,254,822 | [['D08.811.520.650.200', 'D12.644.360.050', 'D12.776.476.050'], ['B01.050'], ['D06.472.699.322.326', 'D06.472.699.649.367', 'D12.644.548.726.367', 'D12.776.780.400'], ['G07.690.773.992'], ['D06.472.699.322.576.288', 'D06.472.699.631.525.343.288', 'D12.644.548.691.525.343.288'], ['D06.472.699.322'], ['A05.360.319.114.63... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Impact of domain knowledge on blinded predictions of binding energies by alchemical free energy calculations. | The Drug Design Data Resource (D3R) consortium organises blinded challenges to address the latest advances in computational methods for ligand pose prediction, affinity ranking, and free energy calculations. Within the context of the second D3R Grand Challenge several blinded binding free energies predictions were made... | ['Binding Sites', 'Computer-Aided Design', 'Crystallography, X-Ray', 'Databases, Protein', 'Drug Design', 'Humans', 'Ligands', 'Molecular Docking Simulation', 'Protein Binding', 'Protein Conformation', 'Receptors, Cytoplasmic and Nuclear', 'Thermodynamics'] | 29,134,431 | [['G02.111.570.120'], ['L01.224.108.150', 'L01.296.110.150'], ['E05.196.309.742.225'], ['L01.313.500.750.300.188.400.300.750', 'L01.313.500.750.300.188.400.325.710', 'L01.470.750.750.300.750', 'L01.470.750.750.325.710'], ['E05.290.500', 'H01.158.703.007.338.500', 'H01.181.466.338.500'], ['B01.050.150.900.649.313.988.40... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Comparison of two techniques for the evaluation of fetomaternal hemorrhage in RhD-negative women: gel agglutination and haemoglobin F determination by flow cytometry. | BACKGROUND: In the treatment of RhD-negative women, it is clinically important to adjust the RhD immunoglobulin dose to the volume of the fetal-maternal hemorrhage (FMH). The present study compared a standard flow cytometry technique for FMH quantification to a simple alternative, the gel agglutination test.METHODS: Bl... | ['Adult', 'Agglutination Tests', 'Female', 'Fetal Hemoglobin', 'Fetomaternal Transfusion', 'Flow Cytometry', 'Humans', 'Infant, Newborn', 'Israel', 'Pregnancy', 'Regression Analysis', 'Rh-Hr Blood-Group System', 'Rho(D) Immune Globulin'] | 17,611,827 | [['M01.060.116'], ['E01.370.225.812.735.050', 'E05.200.812.735.050', 'E05.478.594.760.050'], ['D12.776.124.400.303', 'D12.776.422.316.762.320'], ['C15.378.071.363.511', 'C16.614.053.511'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.200.500.386.350',... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Neutral amino acid transport in mouse peritoneal macrophages. | Neutral amino acid transport has been characterized in the mouse peritoneal macrophages elicited by thioglycolate broth. Serine, alanine, cysteine, and leucine were transported mainly in a Na+-independent manner and, within the concentration ranges tested, the transport of each amino acid was mediated by a single, satu... | ['Alanine', 'Amino Acids', 'Animals', 'Biological Transport', 'Cells, Cultured', 'Cysteine', 'Kinetics', 'Leucine', 'Macrophages', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Serine', 'Tritium'] | 3,115,975 | [['D12.125.042'], ['D12.125'], ['B01.050'], ['G03.143'], ['A11.251'], ['D02.886.030.230', 'D02.886.489.155', 'D12.125.154.299', 'D12.125.166.230'], ['G01.374.661', 'G02.111.490'], ['D12.125.070.637', 'D12.125.142.441'], ['A11.329.372', 'A11.627.482', 'A11.733.397', 'A15.382.670.522', 'A15.382.680.397'], ['B01.050.150.9... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Maternal smoking during pregnancy and kidney volume in the offspring: the Generation R Study. | An adverse fetal environment leads to smaller kidneys, with fewer nephrons, which might predispose an individual to the development of kidney disease and hypertension in adult life. In a prospective cohort study among 1,072 children followed from early fetal life onward, we examined whether maternal smoking during preg... | ['Cohort Studies', 'Female', 'Fetal Development', 'Humans', 'Infant, Newborn', 'Kidney', 'Male', 'Pregnancy', 'Prenatal Exposure Delayed Effects', 'Smoking', 'Ultrasonography'] | 21,617,916 | [['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['G07.345.500.325.235', 'G08.686.784.170.157'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['A05.810.453'], ['G08.686.784.769'], ['C13.703.824.500'], ['F01.145.805'], ['E01.370.350.850']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A case of a 6-year-old girl with anti-neutrophil cytoplasmic autoantibody-negative pauci-immune crescentic glomerulonephritis. | A 6-year-old girl was admitted to our hospital with proteinuria, hematuria, skin rash and joint pain of the lower limbs. Due to rapid progression of renal insufficiency, hemodialysis and peritoneal dialysis were performed. She was diagnosed with rapidly progressive glomerulonephritis. Kidney biopsy showed severe cresce... | ['Antibodies, Antineutrophil Cytoplasmic', 'Autoantibodies', 'Child', 'Cyclophosphamide', 'Drug Therapy, Combination', 'Female', 'Glomerulonephritis', 'Humans', 'Methylprednisolone', 'Plasmapheresis', 'Prednisolone', 'Proteinuria', 'Pulse Therapy, Drug'] | 21,360,022 | [['D12.776.124.486.485.114.323.190', 'D12.776.124.790.651.114.323.190', 'D12.776.377.715.548.114.323.190', 'D23.101.050'], ['D12.776.124.486.485.114.323', 'D12.776.124.790.651.114.323', 'D12.776.377.715.548.114.323'], ['M01.060.406'], ['D02.455.526.728.650.730.243', 'D02.705.672.500.243'], ['E02.319.310'], ['C12.777.41... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Populations of Ixodes scapularis (Acari: Ixodidae) are modulated by drought at a Lyme disease focus in Illinois. | From 1990 through 1997, Ixodes scapularis Say larvae and nymphs were sampled between May and October along a 400-m segment of a nature trail in a Lyme disease endemic site in northern Illinois. Ticks were removed from Peromyscus leucopus mice and collected via tick drags at approximately 3-wk intervals. Mouse populatio... | ['Animals', 'Climate', 'Disasters', 'Humans', 'Illinois', 'Ixodes', 'Lyme Disease', 'Population'] | 15,535,585 | [['B01.050'], ['G16.500.275.071', 'N06.230.300.100.250'], ['N06.230.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.107.567.875.350.350', 'Z01.107.567.875.510.350'], ['B01.050.500.131.166.132.832.400.425'], ['C01.150.252.400.536', 'C01.150.252.400.794.352.250', 'C01.920.930.513'], ['N01.600']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Geographicals [Z]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Immunolocalization of the G protein alpha subunit encoded by the GPA1 gene in Arabidopsis. | Heterotrimeric GTP binding proteins (G proteins) are important signal transducers in lower eukaryotes and in animal cells. In plants, the occurrence of GTP binding proteins has been reported, but their biological function remains unclear. Two genes coding for G protein alpha subunits have been cloned: GPA1 in Arabidops... | ['Amino Acid Sequence', 'Arabidopsis', 'GTP-Binding Proteins', 'Genes, Plant', 'Immunoblotting', 'Molecular Sequence Data', 'Plant Proteins', 'Pollen', 'Seeds'] | 8,312,737 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.650.940.800.575.912.250.157.100'], ['D08.811.277.040.330.300', 'D12.776.157.325'], ['G05.360.340.024.340.393', 'G05.360.340.365.500'], ['E05.478.566.320', 'E05.601.470.320'], ['L01.453.245.667'], ['D12.776.765'], ['A18.024.249.500.249.500'], ['A18.024.500.750', 'G07.20... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Metabolism of butadiene monoxide by freshly isolated hepatocytes from mice and rats: different partitioning between oxidative, hydrolytic, and conjugation pathways. | 1,3-Butadiene (BD) is a multisite carcinogen in rodents, with mice being much more susceptible than rats. This species difference in carcinogenicity has been attributed to differences in metabolism. In this study, coordinated metabolism of butadiene monoxide (BMO, 5, 25, and 250 microM), the primary reactive metabolite... | ['Animals', 'Epoxy Compounds', 'Gas Chromatography-Mass Spectrometry', 'Glutathione', 'Hepatocytes', 'Hydrolysis', 'Male', 'Mice', 'Oxidation-Reduction', 'Rats', 'Rats, Sprague-Dawley'] | 11,353,751 | [['B01.050'], ['D02.355.291.411'], ['E05.196.181.349.500', 'E05.196.566.500'], ['D12.644.456.448'], ['A11.436.348'], ['G02.380'], ['B01.050.150.900.649.313.992.635.505.500'], ['G02.700', 'G03.295.531'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.750']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Service Delivery Correlates of Choosing Short-Acting Contraceptives at the Time of Uterine Evacuation in Bangladesh. | CONTEXT: The World Health Organization recommends that contraceptives be offered on the day of a uterine evacuation procedure (i.e., induced abortion or postabortion care for an incomplete abortion). Short-acting methods can be initiated on the day of the uterine evacuation, regardless of procedure type.METHODS: Survey... | ['Abortion, Induced', 'Adolescent', 'Adult', 'Aftercare', 'Bangladesh', 'Contraception', 'Contraceptive Agents, Female', 'Contraceptives, Postcoital', 'Databases, Factual', 'Delivery of Health Care', 'Developing Countries', 'Female', 'Humans', 'Middle Aged', 'Patient Preference', 'Pregnancy', 'Surveys and Questionnaire... | 29,261,504 | [['E04.520.050'], ['M01.060.057'], ['M01.060.116'], ['E02.760.169.063', 'N02.421.585.169.063', 'N04.590.233.727.210.063'], ['Z01.252.245.131'], ['E02.875.194'], ['D27.505.696.875.360.276', 'D27.505.954.705.360.276'], ['D27.505.696.875.360.276.310', 'D27.505.954.705.360.276.310'], ['L01.313.500.750.300.188.400', 'L01.47... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Health Care [N]', 'Geographicals [Z]', 'Chemicals and Drugs [D]', 'Information Science [L]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Proc... | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
Development of a native Escherichia coli induction system for ionic liquid tolerance. | The ability to solubilize lignocellulose makes certain ionic liquids (ILs) very effective reagents for pretreating biomass prior to its saccharification for biofuel fermentation. However, residual IL in the aqueous sugar solution can inhibit the growth and function of biofuel-producing microorganisms. In E. coli this t... | ['Escherichia coli', 'Escherichia coli Proteins', 'Ionic Liquids', 'Promoter Regions, Genetic', 'RNA, Bacterial', 'Transcriptome'] | 24,983,352 | [['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D12.776.097.275'], ['D27.720.844.500'], ['G02.111.570.080.689.675', 'G05.360.080.689.675', 'G05.360.340.024.340.137.750.680'], ['D13.444.735.473'], ['G02.111.873.750', 'G05.297.700.750', 'G05.360.920']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Molecular characterisation and expression analysis of SEREX-defined antigen NUCB2 in gastric epithelium, gastritis and gastric cancer. | NUCB2 is an EF-hand Ca2+ binding protein that has been implicated in various physiological processes like calcium homeostasis, hypothalamic regulation of feeding and TNF receptor shedding. In our previous study we identified NUCB2 as a potential tumour antigen eliciting autoantibody responses in 5.4% of gastric cancer ... | ['Adult', 'Aged', 'Aged, 80 and over', 'Autoantibodies', 'Calcium-Binding Proteins', 'DNA-Binding Proteins', 'Down-Regulation', 'Female', 'Gastric Mucosa', 'Gastritis', 'Humans', 'Male', 'Middle Aged', 'Nerve Tissue Proteins', 'Nucleobindins', 'Parietal Cells, Gastric', 'Protein Processing, Post-Translational', 'Revers... | 19,351,608 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D12.776.124.486.485.114.323', 'D12.776.124.790.651.114.323', 'D12.776.377.715.548.114.323'], ['D12.776.157.125'], ['D12.776.260'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['A03.556.875.875.440', 'A10.615.550.291'], ['C06.405.205.697', 'C06.405... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
ROS-mediated bidirectional regulation of miRNA results in distinct pathologic heart conditions. | Under distinct pathological heart conditions, the expression of a single miRNA can display completely opposite patterns. However, the mechanism underlying the bidirectional regulation of a single miRNA and the clinical implications of this regulation remain largely unknown. To address this issue, we examined the regula... | ['Animals', 'Apoptosis', 'Cardiomegaly', 'Cells, Cultured', 'Gene Expression Regulation', 'Heart Failure', 'MicroRNAs', 'Myocardium', 'Nuclear Proteins', 'Rats', 'Rats, Sprague-Dawley', 'Reactive Oxygen Species', 'Trans-Activators'] | 26,253,469 | [['B01.050'], ['G04.146.954.035'], ['C14.280.195', 'C23.300.775.250'], ['A11.251'], ['G05.308'], ['C14.280.434'], ['D13.150.650.319', 'D13.444.735.150.319', 'D13.444.735.790.552.500'], ['A02.633.580', 'A07.541.704', 'A10.690.552.750'], ['D12.776.660'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Reduction of subcutaneous mass, but not lean mass, in normal fetuses in Denver, Colorado. | OBJECTIVE: To test the hypothesis that reduced birth weight in normal fetuses born at moderately high altitude (Denver), compared with the birth weight in normal fetuses born at sea level (Milan), is caused by a reduction in both lean mass and subcutaneous fat mass.STUDY DESIGN: Ninety-four normal singleton pregnancies... | ['Adipose Tissue', 'Adult', 'Altitude', 'Body Composition', 'Body Mass Index', 'Colorado', 'Female', 'Fetal Growth Retardation', 'Humans', 'Italy', 'Muscle, Skeletal', 'Pregnancy', 'Probability', 'Reference Values', 'Sensitivity and Specificity', 'Ultrasonography, Prenatal'] | 11,641,662 | [['A10.165.114'], ['M01.060.116'], ['G16.500.275.058', 'N06.230.058'], ['G02.111.130', 'G03.180', 'G07.100.049'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['Z01.107.567.875.760.210'], ['C13.703.277.370', 'C16.300.390', 'C23.550.393.450'], ['B01.050.150.900.649.313.98... | ['Anatomy [A]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Imprinting analysis of porcine DIO3 gene in two fetal stages and association analysis with carcass and meat quality traits. | Imprinted genes play important roles in mammalian growth, development and behavior. In this study, we obtained 1568 bp mRNA sequence of porcine DIO3 (deiodinase, iodothyronine, type III), and also identified its imprinting status during porcine fetal development. The complete open reading frame (ORF) encoding 278 amino... | ['Animals', 'Body Composition', 'Cloning, Molecular', 'DNA Primers', 'Fetus', 'Gene Expression Regulation, Developmental', 'Gene Frequency', 'Genetic Association Studies', 'Genomic Imprinting', 'Iodide Peroxidase', 'Linear Models', 'Meat', 'Polymorphism, Single Nucleotide', 'Real-Time Polymerase Chain Reaction', 'Sus s... | 21,660,470 | [['B01.050'], ['G02.111.130', 'G03.180', 'G07.100.049'], ['E05.393.220'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['A16.378'], ['G05.308.310'], ['G05.330'], ['E05.393.385'], ['G05.308.203.500'], ['D08.811.682.732.525'], ['E05.318.740.500.500', 'E05.318.740.750.425', 'E05.599.835.750', 'N05.715.360.7... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Leukocyte reactivity as an objective means of quantifying mental loading during ergonomic evaluation. | Psychological stress evokes rapid changes to the cardiovascular and neuroendocrine systems, responses that can become habituated following repeated exposure. This study, comprising of two phases, suggests that the immune system follows a similar trend. Phase 1: 15 healthy subjects (aged between 26 and 56years) provided... | ['Adaptation, Psychological', 'Adult', 'Blood Pressure', 'Body Temperature', 'Ergonomics', 'Feasibility Studies', 'Female', 'Heart Rate', 'Humans', 'Leukocytes, Mononuclear', 'Male', 'Middle Aged', 'Psychological Tests', 'Reactive Oxygen Species', 'Stress, Psychological'] | 20,299,010 | [['F01.058'], ['M01.060.116'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E01.370.600.875.374', 'G07.110'], ['F02.784.412', 'J01.293.556'], ['E05.318.372.550', 'E05.337.675', 'N05.715.360.330.550', 'N06.850.520.450.550'], ['E01.370.600.875.500', 'G09.330.380.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['... | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Family socio-demographic factors and maternal obstetric factors influencing appropriate health-care seeking behaviours for newborn jaundice in Sagamu, Nigeria. | Poor care-seeking behaviour of families may be responsible for the high prevalence of complications of newborn jaundice in the developing world. To examine the influence of family socio-demographic characteristics and maternal obstetric factors on health care-seeking behaviours for newborn jaundice and the inter-relati... | ['Adolescent', 'Adult', 'Bilirubin', 'Child', 'Child Health Services', 'Cross-Sectional Studies', 'Female', 'Gestational Age', 'Health Behavior', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Infant', 'Infant, Newborn', 'Jaundice, Neonatal', 'Male', 'Maternal Age', 'Mothers', 'Nigeria', 'Patient Acceptance of Hea... | 21,365,297 | [['M01.060.057'], ['M01.060.116'], ['D03.383.129.578.840.249.184', 'D03.633.400.909.249.184', 'D04.345.783.249.184', 'D23.767.193.184'], ['M01.060.406'], ['N02.421.143.130'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['G07.345.500.325.235.968', 'G08.686.320'], ['F01.145.488'], ['F01... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
[Clock synchronization in various modes of regulation]. | In this study, which is dedicated to the participants of I. M. Gelfand's scientific seminar, the regulation mechanisms for the clock synchronization in an isolated biological community are analyzed. A comparison has been carried out of the time consumed and the work done taking into account the specific error value for... | ['Animals', 'Biological Clocks', 'Circadian Rhythm', 'Humans', 'Models, Biological'] | 17,969,933 | [['B01.050'], ['G07.180.562.094'], ['G07.180.562.190'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.395']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Transformation of MALT lymphoma to pure plasma cell histology following treatment with the anti-CD20 antibody rituximab. | Mucosa associated lymphoid tissue (MALT) lymphoma is a relatively common lymphoma arising from marginal-zone B-cells which are closely related to plasma cells. As opposed to the large majority of plasma cells, MALT lymphoma cells express CD20, and the anti-CD20 antibody rituximab has been reported as active treatment i... | ['Aged, 80 and over', 'Antibodies, Monoclonal', 'Antibodies, Monoclonal, Murine-Derived', 'Cell Differentiation', 'Fluorodeoxyglucose F18', 'Humans', 'Lung Neoplasms', 'Lymphoma, B-Cell, Marginal Zone', 'Male', 'Plasma Cells', 'Rituximab', 'Stomach Neoplasms', 'Treatment Outcome'] | 16,236,618 | [['M01.060.116.100.080'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D12.776.124.486.485.114.224.075', 'D12.776.124.790.651.114.224.075', 'D12.776.377.715.548.114.224.284'], ['G04.152'], ['D09.254.229.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Activity and subunit composition of proteasomes in head and cervical squamous cell carcinomas. | The development of malignant neoplasm of the head and neck is related to the state of intracellular proteasome system. Elevation of total activity of proteasomes and specific activity of 20S proteasomal pool are accompanied by changes in proteasomal composition. Tumor size correlated with the content of regulatory prot... | ['Carcinoma, Squamous Cell', 'Chemical Fractionation', 'Electrophoresis, Polyacrylamide Gel', 'Fluorometry', 'Head and Neck Neoplasms', 'Humans', 'Middle Aged', 'Proteasome Endopeptidase Complex', 'Statistics, Nonparametric'] | 21,113,465 | [['C04.557.470.200.400', 'C04.557.470.700.400'], ['E05.196.155'], ['E05.196.401.402', 'E05.301.300.319'], ['E05.196.712.516.600'], ['C04.588.443'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['D05.500.562.500', 'D08.811.277.656.918', 'D08.811.600.730'], ['E05.318.740.995', 'N05.715.360.750.76... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Stratifying fibrinolytic dosing in pediatric parapneumonic effusion based on ultrasound grade correlation. | BACKGROUND: Complicated pleural effusion prolongs the hospital course of pneumonia. Chest tube placement with instillation of fibrinolytic medication allows efficient drain output and decreases hospital stay.OBJECTIVE: To evaluate experience with lower fibrinolytic dose for parapneumonic effusions and to assess potenti... | ['Adolescent', 'Chest Tubes', 'Child', 'Child, Preschool', 'Combined Modality Therapy', 'Drainage', 'Female', 'Fibrinolytic Agents', 'Humans', 'Infant', 'Male', 'Pleural Effusion', 'Pneumonia', 'Retrospective Studies', 'Tissue Plasminogen Activator', 'Treatment Outcome', 'Ultrasonography, Interventional', 'Young Adult'... | 27,709,281 | [['M01.060.057'], ['E07.858.150'], ['M01.060.406'], ['M01.060.406.448'], ['E02.186'], ['E02.309', 'E04.237'], ['D27.505.519.421.750', 'D27.505.954.411.320', 'D27.505.954.502.427'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['C08.528.652'], ['C01.748.610', 'C08.381.677', 'C08.730.610'], ['E05.318... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
áII Spectrin Forms a Periodic Cytoskeleton at the Axon Initial Segment and Is Required for Nervous System Function. | Spectrins form a submembranous cytoskeleton proposed to confer strength and flexibility to neurons and to participate in ion channel clustering at axon initial segments (AIS) and nodes of Ranvier. Neuronal spectrin cytoskeletons consist of diverse â subunits and áII spectrin. Although áII spectrin is found in neurons i... | ['Action Potentials', 'Animals', 'Axons', 'COS Cells', 'Cells, Cultured', 'Chlorocebus aethiops', 'Cytoskeleton', 'Gene Deletion', 'Hippocampus', 'Mice', 'Mice, Inbred C57BL', "Ranvier's Nodes", 'Spectrin'] | 29,038,240 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['B01.050'], ['A08.675.542.145', 'A11.284.180.075', 'A11.671.137', 'A11.671.501.145'], ['A11.251.210.172.500', 'A11.329.228.220'], ['A11.251'], ['B01.050.150.900.649.313.988.400.112.199.120.126.110'], ['A11.284.430.214.190.750'], ['G05.365.590.762.320', 'G05.558.8... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A sensitive fluorescent assay for N-acetyltransferase activity in human lymphocytes from newborns and adults. | We have developed a simplified assay for the enzyme N-acetyltransferase, based upon the loss of fluorescence after acetylation of the substrate p-aminobenzoic acid. This method is sufficiently sensitive to permit the quantitation of N-acetyltransferase activity in 10(5) human lymphocytes. Using this method, we have com... | ['Acetyltransferases', 'Adult', 'Age Factors', 'Fetal Blood', 'Humans', 'Infant, Newborn', 'Lymphocytes', 'Spectrometry, Fluorescence'] | 476,964 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Development and evaluation of an ultrasensitive free VEGF-A immunoassay for analysis of human aqueous humor. | Aim: Novel bifunctional VEGF-A neutralizing therapies are being developed for the treatment of retinal vascular diseases such as age-related macular degeneration and diabetic retinopathy. In developing new therapeutic drugs, only small aqueous humor sample volumes are available for analyzing several parameters. Highly ... | ['Aqueous Humor', 'Calibration', 'Diabetes Complications', 'Humans', 'Immunoassay', 'Limit of Detection', 'Macular Edema', 'Vascular Endothelial Growth Factor A'] | 31,070,047 | [['A09.371.060.067.070', 'A12.207.270.040'], ['E05.978.155'], ['C19.246.099'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.478.566', 'E05.601.470'], ['E05.318.740.872.374', 'N05.715.360.750.725.500', 'N06.850.520.830.872.500'], ['C11.768.585.439.245'], ['D12.644.276.100.800.200', 'D12.776.467.100.800.200', '... | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Interaction of zinc protoporphyrin with intact oxyhemoglobin. | In erythropoietic protoporphyria and lead poisoning, free protoporphyrin (PPIX) and zinc protoporphyrin (ZPP), respectively, accumulate in erythrocytes. That PPIX and ZPP bind to human hemoglobin A (Hb4) is established, but the site of binding is still a matter of controversy. We investigated the interaction of ZPP wit... | ['Calorimetry', 'Humans', 'Kinetics', 'Macromolecular Substances', 'Oxyhemoglobins', 'Porphyrins', 'Protein Binding', 'Protoporphyrins', 'Spectrometry, Fluorescence', 'Spectrophotometry'] | 2,719,938 | [['E05.196.131'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.374.661', 'G02.111.490'], ['D05'], ['D12.776.124.400.707', 'D12.776.422.316.762.687'], ['D03.383.129.578.840.500', 'D03.633.400.909.500', 'D04.345.783.500', 'D23.767.727'], ['G02.111.679', 'G03.808'], ['D03.383.129.578.840.500.725', 'D03.633.400.9... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Effectiveness and adaptation to food quality of the starch-glucose conveyor following section of the bile and pancreatic ducts in rats]. | Membrane hydrolysis and carbohydrate transport were determined 2 hours after bread or meat feeding of rats on the 4th, 7th, and 14th day after the ligation of the bile-pancreatic duct in various segments of the small intestine. Even with a sharp reduction of the amylolytic activity of the mucosa surface, the transport ... | ['Animals', 'Biological Transport', 'Bread', 'Dietary Carbohydrates', 'Glucose', 'Hydrolysis', 'Intestinal Absorption', 'Intestinal Mucosa', 'Meat', 'Rats', 'Starch', 'Sucrose'] | 870,106 | [['B01.050'], ['G03.143'], ['G07.203.300.100', 'J02.500.100'], ['D09.301', 'G07.203.300.362', 'J02.500.362'], ['D09.947.875.359.448'], ['G02.380'], ['G03.015.500.374.500', 'G03.787.024.500.374.500', 'G07.203.650.372.500', 'G07.690.725.015.500.374.500', 'G10.261.353.500'], ['A03.556.124.369', 'A10.615.550.444'], ['G07.2... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Cloning and analysis of the murine Fanconi anemia group C cDNA. | Fanconi anemia (FA) is one of a group of disorders characterized at the cellular level by a combination of hypersensitivity to DNA-damaging agents, chromosomal instability, and defective DNA repair. Clinical features of FA include pancytopenia, often accompanied by specific congenital malformations, and a predispositio... | ['Amino Acid Sequence', 'Animals', 'Base Sequence', 'Cell Cycle Proteins', 'Cells, Cultured', 'Chickens', 'Cloning, Molecular', 'Cross-Linking Reagents', 'DNA', 'DNA-Binding Proteins', 'Drosophila', 'Drug Resistance', 'Embryonic and Fetal Development', 'Fanconi Anemia', 'Fanconi Anemia Complementation Group C Protein',... | 7,689,006 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D12.776.167'], ['A11.251'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['E05.393.220'], ['D27.720.470.410.210'], ['D13.444.308'], ['D12.776.260'], ['B01.050.500.131.617.720.500.500... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Experimental infection and transmission of Leishmania by Lutzomyia cruzi (Diptera: Psychodidae): Aspects of the ecology of parasite-vector interactions. | Several parameters should be addressed before incriminating a vector for Leishmania transmission. Those may include its ability to become infected by the same Leishmania species found in humans, the degree of attractiveness for reservoirs and humans and capacity to sustain parasite infection under laboratory conditions... | ['Animals', 'Cricetinae', 'Dogs', 'Ecosystem', 'Female', 'Host-Parasite Interactions', 'Humans', 'Insect Vectors', 'Leishmania infantum', 'Leishmaniasis, Visceral', 'Male', 'Psychodidae'] | 28,234,913 | [['B01.050'], ['B01.050.150.900.649.313.992.635.075.250'], ['B01.050.150.900.649.313.750.250.216.200'], ['G16.500.275.157', 'N06.230.124'], ['G16.527.200.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N06.850.335.188.100.500', 'N06.850.520.203.375.100.500'], ['B01.268.475.868.488.325'], ['C01.610.752.300.500... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Cardiac and pulmonary doses and complication probabilities in standard and conformal tangential irradiation in conservative management of breast cancer. | BACKGROUND AND PURPOSE: The clinical benefit of irradiating the intact breast after lumpectomy must be weighted against the risk of severe toxicity. We present a study on cardiac and pulmonary dose-volume data and the related complication probabilities of tangential breast irradiation having the following objectives: (... | ['Adult', 'Aged', 'Breast Neoplasms', 'Dose-Response Relationship, Radiation', 'Female', 'Heart Diseases', 'Humans', 'Lung Diseases', 'Mastectomy, Segmental', 'Middle Aged', 'Models, Biological', 'Pericarditis', 'Probability', 'Radiation Injuries', 'Radiation Pneumonitis', 'Radiation Tolerance', 'Radiotherapy Planning,... | 11,937,244 | [['M01.060.116'], ['M01.060.116.100'], ['C04.588.180', 'C17.800.090.500'], ['E05.799.513.500', 'G01.750.740.500', 'G04.712.500', 'G07.225', 'G07.738.500', 'N06.850.810.250.180'], ['C14.280'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C08.381'], ['E04.466.701'], ['M01.060.116.630'], ['E05.599.395'], ['C14.280.7... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Information Science [L]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
[Implant-free anterior cruciate ligament reconstruction with diamond instruments. A biological and anatomic method for every ligament transplantation]. | UNLABELLED: Hamstring and patella tendons are usually used for anterior cruciate ligament (ACL) reconstruction and fixed with foreign material, partially executed far from the original point of insertion. Besides the biomechanical questions bone defects are a severe problem in cases of revision. We developed a biologic... | ['Adolescent', 'Adult', 'Anterior Cruciate Ligament', 'Anterior Cruciate Ligament Injuries', 'Biomechanical Phenomena', 'Diamond', 'Equipment Design', 'Female', 'Follow-Up Studies', 'Humans', 'Joint Instability', 'Knee Injuries', 'Male', 'Middle Aged', 'Postoperative Complications', 'Prospective Studies', 'Prostheses a... | 20,697,863 | [['M01.060.057'], ['M01.060.116'], ['A02.513.514.100', 'A02.835.583.512.100', 'A10.165.669.514.100'], ['C26.558.554.213'], ['G01.154.090', 'G01.374.089'], ['D01.268.150.200'], ['E05.320'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.40... | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Chronic pain treatment: a high moral imperative with offsetting personal risks for the physician--a medical student's perspective. | There is a clear need for physicians who specialize in the treatment of chronic pain, and these specialists must be empowered to use legally available and medically acceptable pain therapies, including opioids. However, prescribing opioids (or not prescribing them) for chronic pain treatment exposes pain physicians to ... | ['Analgesics, Opioid', 'Chronic Disease', 'Education, Medical', 'Humans', 'Moral Obligations', 'Pain Management', 'Physicians', 'Risk', 'Students, Medical'] | 19,140,905 | [['D27.505.696.277.600.500', 'D27.505.696.663.850.014.760.500', 'D27.505.954.427.040.550.500', 'D27.505.954.427.210.600.500'], ['C23.550.291.500'], ['I02.358.399'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.500.760.500', 'K01.752.566.869.500'], ['E02.745', 'N04.590.607.500'], ['M01.526.485.810', 'N02.3... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Humanities [K]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Named Groups [M]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Enhanced expression of cyclin-dependent kinase inhibitor in apoptosis of androgen-independent prostatic cancer cell line induced by calcium ionophore. | In order to examine the relationship between apoptosis of androgen-independent prostatic cancer cells and cell cycle-associated proteins, TSU-pr1 human prostatic cancer cells were chronically exposed in vitro to the calcium ionophore ionomycin to sustain an elevation in their intracellular free calcium concentration. T... | ['Androgens', 'Apoptosis', 'Calcium', 'Cell Cycle', 'Cell Cycle Proteins', 'Cyclin-Dependent Kinase Inhibitor p21', 'Cyclin-Dependent Kinase Inhibitor p27', 'Cyclins', 'DNA Fragmentation', 'DNA, Neoplasm', 'Humans', 'Ionomycin', 'Male', 'Microtubule-Associated Proteins', 'Prostatic Neoplasms', 'Time Factors', 'Tumor Ce... | 9,252,652 | [['D27.505.696.399.472.161'], ['G04.146.954.035'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['G04.144'], ['D12.776.167'], ['D12.644.360.225.500', 'D12.776.157.687.250', 'D12.776.167.187.500', 'D12.776.476.225.500', 'D12.776.624.776.355.500', 'D12.776.660.720.250'], ['D12.644.360.225.600', 'D12.776.167.187... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Lateral differences in schematic face encoding during dual-task performance with increasing levels of difficulty. | 20 normal, right-handed, familial dextral men performed (a) unimanual finger tapping, (b) encoding of schematic faces at three levels of difficulty (3, 5, and 7 faces), (c) verbal production, (d) concurrent tapping and verbal production, and (e) concurrent tapping and face encoding. Subsequent recognition of faces was ... | ['Adult', 'Attention', 'Dominance, Cerebral', 'Face', 'Form Perception', 'Humans', 'Male', 'Memory', 'Memory, Short-Term', 'Mental Recall', 'Motor Activity', 'Pattern Recognition, Visual', 'Verbal Behavior'] | 2,748,292 | [['M01.060.116'], ['F02.830.104.214'], ['F02.830.297', 'G11.561.225'], ['A01.456.505'], ['F02.463.593.373', 'F02.463.593.778.435'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.425.540'], ['F02.463.425.540.407'], ['F02.463.425.540.641'], ['F01.145.632', 'G11.427.410.698'], ['F02.463.593.524.500', 'F02.463... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Improved detection of CD5 epitope in formalin-fixed paraffin-embedded sections of benign and neoplastic lymphoid tissues by using biotinylated tyramine enhancement after antigen retrieval. | To evaluate the effectiveness of the immunohistochemical staining of B- and T-cell lymphomas with Leu-1 (clone L17F12 CD5 antibody, Becton Dickinson, San Jose, Calif) in formalin-fixed paraffin-embedded sections, we stained 12 specimens reflecting cases of chronic lymphocytic leukemia/small lymphocytic lymphoma, 7 of m... | ['Biotinylation', 'CD3 Complex', 'CD5 Antigens', 'Fixatives', 'Flow Cytometry', 'Formaldehyde', 'Humans', 'Lymphoma, B-Cell', 'Lymphoma, T-Cell', 'Paraffin', 'Receptors, IgE', 'Tissue Embedding', 'Tyramine'] | 9,620,024 | [['E05.601.085', 'G02.111.109', 'G03.162'], ['D23.050.301.264.894.095', 'D23.101.100.894.095'], ['D23.050.301.264.051.101', 'D23.050.301.264.894.101', 'D23.101.100.150.101', 'D23.101.100.894.101'], ['D27.720.355'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.34... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Clampless laparoscopic partial nephrectomy: a step towards a harmless nephron-sparing surgery? | PURPOSE: To evaluate the results of our technique of clampless laparoscopic partial nephrectomy (LPN) and its impact as an emerging treatment for small renal masses (SMRs).MATERIALS AND METHODS: We reviewed our prospectively maintained database: data of 117 patients who consecutively underwent LPN at our Institution fr... | ['Aged', 'Chi-Square Distribution', 'Female', 'Glomerular Filtration Rate', 'Humans', 'Laparoscopy', 'Male', 'Middle Aged', 'Nephrectomy', 'Nephrons', 'Organ Sparing Treatments', 'Postoperative Period', 'Preoperative Period', 'Retrospective Studies', 'Time Factors', 'Treatment Outcome'] | 22,951,177 | [['M01.060.116.100'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['E01.370.390.400.300', 'G08.852.357'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.388.250.520', 'E04.502.250.520'], ['M01.060.116.630'], ['E04.950.774.435'], ['A05.810.453.736'], ['E02.67... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Highly selective and sensitive nucleic acid detection based on polysaccharide-functionalized silver nanoparticles. | Polysaccharide-functionalized silver nanoparticles (Oc-AgNPs) with a mean diameter of 15 nm were utilized as a novel and effective fluorescence-sensing platform for nucleic acid detection. Tests on the oligonucleotide sequences associated with the human immunodeficiency virus as a model system showed that the Oc-AgNPs ... | ['DNA, Single-Stranded', 'Fluorescent Dyes', 'HIV', 'Kinetics', 'Nanoparticles', 'Oligonucleotides', 'Polysaccharides', 'Reproducibility of Results', 'Silver', 'Spectrometry, Fluorescence', 'Static Electricity'] | 24,995,414 | [['D13.444.308.497', 'G02.111.570.820.486.437', 'G05.360.580.437'], ['D27.720.233.348', 'D27.720.470.410.505.500'], ['B04.820.650.589.650.350'], ['G01.374.661', 'G02.111.490'], ['J01.637.512.600'], ['D13.695.578.424'], ['D09.698'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['D01.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Effect of postdiagnosis weight change on hot flash status among early-stage breast cancer survivors. | PURPOSE: Hot flashes (HF) affect a large proportion of breast cancer (BC) survivors and can negatively affect their quality of life. Treatments other than estrogen replacement to alleviate HF are needed. Body weight is related to hot flashes, but little is known about the effect of weight change on HF.PATIENTS AND METH... | ['Adult', 'Antineoplastic Agents, Hormonal', 'Breast Neoplasms', 'Chi-Square Distribution', 'Early Detection of Cancer', 'Estrogen Receptor Modulators', 'Female', 'Hot Flashes', 'Humans', 'Logistic Models', 'Middle Aged', 'Neoplasm Staging', 'Odds Ratio', 'Risk Assessment', 'Risk Factors', 'Survivors', 'Time Factors', ... | 22,430,275 | [['M01.060.116'], ['D27.505.954.248.169'], ['C04.588.180', 'C17.800.090.500'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['E01.390.500'], ['D06.347.360', 'D27.505.696.399.450.360'], ['C23.888.475'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.52... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Terconazole for the treatment of vulvovaginal candidiasis. | A double-blind, randomized trial was conducted to evaluate the efficacy and safety of terconazole for vulvovaginal candidiasis. Treatment consisted of daily intravaginal application of one of the following regimens: 80-mg terconazole suppositories for 3 days, miconazole nitrate suppositories for 7 days or placebo suppo... | ['Administration, Intravaginal', 'Adolescent', 'Adult', 'Antifungal Agents', 'Candidiasis, Vulvovaginal', 'Double-Blind Method', 'Female', 'Humans', 'Miconazole', 'Suppositories', 'Triazoles'] | 2,277,372 | [['E02.319.267.120.500'], ['M01.060.057'], ['M01.060.116'], ['D27.505.954.122.136'], ['C01.150.703.160.190', 'C13.351.500.894.906.820.500', 'C13.351.500.944.902.737.500'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.383.129... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Visual Field Outcome Reporting in Neurosurgery: Lessons Learned from a Prospective, Multicenter Study of Transsphenoidal Pituitary Surgery. | OBJECTIVE: Visual field (VF) outcomes are commonly reported in neurosurgical case series; however, substantial variability can exist in VF testing and outcome reporting. We aimed to evaluate the challenges of VF testing and to develop detailed recommendations for VF outcome reporting by analyzing results from an ongoin... | ['Adenoma', 'Adult', 'Aged', 'Female', 'Humans', 'Male', 'Middle Aged', 'Neurosurgical Procedures', 'Pituitary Neoplasms', 'Prospective Studies', 'Reproducibility of Results', 'Retrospective Studies', 'Sphenoid Bone', 'Vision Disorders', 'Visual Field Tests', 'Visual Fields'] | 30,144,606 | [['C04.557.470.035'], ['M01.060.116'], ['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E04.525'], ['C04.588.322.609', 'C04.588.614.250.195.885.500.600', 'C10.228.140.211.885.500.600', 'C10.228.140.617.477.600', 'C10.228.140.617.738.675', 'C10.551.240.250.700.500.500', 'C19.3... | ['Diseases [C]', 'Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Accurate estimation of 5-methylcytosine in mammalian mitochondrial DNA. | Whilst 5-methylcytosine (5mC) is a major epigenetic mark in the nuclear DNA in mammals, whether or not mitochondrial DNA (mtDNA) receives 5mC modification remains controversial. Herein, we exhaustively analysed mouse mtDNA using three methods that are based upon different principles for detecting 5mC. Next-generation b... | ['5-Methylcytosine', 'Animals', 'Brain Chemistry', 'Chemistry Techniques, Analytical', 'DNA, Mitochondrial', 'Embryonic Stem Cells', 'Liver', 'Mice', 'Molecular Biology'] | 29,643,477 | [['D03.383.742.698.421.500'], ['B01.050'], ['G02.111.150', 'G03.185'], ['E05.196'], ['D13.444.308.283.225'], ['A11.872.700.250'], ['A03.620'], ['B01.050.150.900.649.313.992.635.505.500'], ['H01.158.201.636', 'H01.158.273.343.595', 'H01.181.122.650']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Weighted least-squares approach for comparing correlated kappa. | In the medical sciences, studies are often designed to assess the agreement between different raters or different instruments. The kappa coefficient is a popular index of agreement for binary and categorical ratings. Here we focus on testing for the equality of two dependent kappa coefficients. We use the weighted leas... | ['Atrophy', 'Bias', 'Biometry', 'Eye Diseases', 'Female', 'Humans', 'Least-Squares Analysis', 'Observer Variation', 'Reproducibility of Results', 'Uterine Cervical Diseases'] | 12,495,157 | [['C23.300.070'], ['N05.715.350.150', 'N06.850.490.500'], ['E05.318.740.225', 'N06.850.505.200'], ['C11'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.750.400', 'N05.715.360.750.695.440', 'N06.850.520.830.750.400'], ['E01.354.753', 'N02.421.450.600', 'N05.715.350.150.675', 'N06.850.490.500.250'], ['E... | ['Diseases [C]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
The Acetylation of Lysine-376 of G3BP1 Regulates RNA Binding and Stress Granule Dynamics. | Stress granules (SGs) are ribonucleoprotein aggregates that form in response to stress conditions. The regulation of SG dynamics is not fully understood. Permanent pathological SG-like structures were reported in neurodegenerative diseases such as amyotrophic lateral sclerosis. The Ras GTPase-activating protein-binding... | ['Acetylation', 'Amino Acid Sequence', 'Animals', 'Cell Line, Tumor', 'Cytoplasmic Granules', 'DNA Helicases', 'HEK293 Cells', 'Histone Deacetylase 6', 'Humans', 'Lysine', 'Mice', 'Mice, Knockout', 'Poly-ADP-Ribose Binding Proteins', 'RNA', 'RNA Helicases', 'RNA Recognition Motif Proteins', 'RNA-Binding Proteins', 'Rib... | 31,481,451 | [['G02.111.012.052', 'G02.607.063.052', 'G03.040.052'], ['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['A11.251.210.190', 'A11.251.860.180'], ['A11.284.430.214.190.500', 'A11.284.430.214.190.875.190.190'], ['D08.811.277.040.025.159', 'D08.811.399.340'], ['A11.251.210.172.750', 'A11.436.334'], ['D08.811.277.0... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Protein-tyrosine phosphatase PTPD1 regulates focal adhesion kinase autophosphorylation and cell migration. | PTPD1 is a cytosolic nonreceptor tyrosine phosphatase and a positive regulator of the Src-epidermal growth factor transduction pathway. We show that PTPD1 localizes along actin filaments and at adhesion plaques. PTPD1 forms a stable complex via distinct molecular modules with actin, Src tyrosine kinase, and focal adhes... | ['Actins', 'Animals', 'Catalysis', 'Cell Adhesion', 'Cytoskeleton', 'Focal Adhesion Protein-Tyrosine Kinases', 'Glutathione Transferase', 'Humans', 'Mice', 'Models, Biological', 'NIH 3T3 Cells', 'Phosphorylation', 'Protein Tyrosine Phosphatases, Non-Receptor', 'Signal Transduction'] | 18,223,254 | [['D05.750.078.730.250', 'D12.776.210.500.100', 'D12.776.220.525.255'], ['B01.050'], ['G02.130'], ['G04.022'], ['A11.284.430.214.190.750'], ['D08.811.913.696.620.682.725.049', 'D12.644.360.287', 'D12.776.476.287'], ['D08.811.913.225.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649.313.992.6... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Cardiac rupture in acute myocardial infarction. Various clinico-anatomical types in 42 recent cases observed over a period of 30 months]. | Forty two cases of complete or incomplete rupture of the free left ventricular wall were reviewed in a group of 136 patients who died of acute myocardial infarction in a Coronary Care Unit and who underwent autopsy examination over a 30 month period. Four groups were distinguished on macro and microscopic features of t... | ['Aged', 'Autopsy', 'Female', 'Heart Rupture', 'Humans', 'Male', 'Middle Aged', 'Myocardial Infarction'] | 3,113,356 | [['M01.060.116.100'], ['E01.370.060', 'E05.070', 'I01.198.780.937.120'], ['C14.280.470'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C14.280.647.500', 'C14.907.585.500', 'C23.550.513.355.750', 'C23.550.717.489.750']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
NaCl-tolerance of Campylobacter isolates from birds and Campylobacter type strains and variation of their serological behaviour. | Growth on media containing 1.5% NaCl is one of the criteria for phenotypical differentiation of Campylobacter laridis from other thermophilic Campylobacter spp. Campylobacter isolates from birds and Campylobacter type strains could be adapted to growth at 3% NaCl within 19 to 72 subsequent passages on nutrient agar wit... | ['Animals', 'Antigenic Variation', 'Antigens, Bacterial', 'Bird Diseases', 'Birds', 'Campylobacter', 'Campylobacter Infections', 'Culture Media', 'Sodium Chloride', 'Specific Pathogen-Free Organisms'] | 8,237,194 | [['B01.050'], ['G05.365.073', 'G12.500.249'], ['D23.050.161'], ['C22.131'], ['B01.050.150.900.248'], ['B03.440.180', 'B03.660.150.235.250.500'], ['C01.150.252.400.177'], ['D27.720.470.305', 'E07.206'], ['D01.210.450.150.875', 'D01.857.650'], ['G06.320.676']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Body fat composition and weight changes after double-jaw osteotomy. | Nutritional problems might be observed after surgical procedures. In this study, body weight and fat composition changes have been investigated in dentofacial deformity patients after the double-jaw osteotomy procedure. Thirty Angle class 3 patients operated on with double-jaw osteotomies during the period of March 200... | ['Adolescent', 'Adult', 'Body Composition', 'Body Weight', 'Electric Impedance', 'Female', 'Humans', 'Male', 'Malocclusion, Angle Class III', 'Nutrition Disorders', 'Occlusal Splints', 'Osteotomy', 'Risk Factors', 'Treatment Outcome', 'Wound Healing'] | 20,818,238 | [['M01.060.057'], ['M01.060.116'], ['G02.111.130', 'G03.180', 'G07.100.049'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['G01.358.500.249.277.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C07.793.494.650'], ['C18.654'], ['E07.858.442... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Lipid composition of milks from cows with experimentally induced mastitis. | Changes in milk lipid composition were measured during the course of mastitis infections induced in cows by infusion of either Escherichia coli endotoxin or Streptococcus agalactiae into 2 quarters of the udder; untreated quarters were used as controls. Experiments were divided into 3 distinct phases: a pre infusion pe... | ['Animals', 'Cattle', 'Cholesterol', 'Escherichia coli', 'Fatty Acids, Nonesterified', 'Female', 'Lactose', 'Lipid Metabolism', 'Lipopolysaccharides', 'Mastitis, Bovine', 'Milk', 'Phospholipids', 'Streptococcus agalactiae'] | 6,373,863 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D10.251.310'], ['D09.698.629.305.340', 'D09.947.750.340'], ['G03.458'], ['D09.400.500', 'D09.698.718.450', 'D10.494', 'D23.050.161.6... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Sartorius muscle flap for body wall reconstruction: Surgical technique description and retrospective case series. | The objectives of this study were to describe the sartorius muscle flap for body wall reconstruction, including description of the anatomy and surgical technique and to report its clinical application for abdominal wall reconstruction in dogs and cats. The descriptive report involves a retrospective case series for 2 d... | ['Abdominal Wall', 'Animals', 'Cat Diseases', 'Cats', 'Dog Diseases', 'Dogs', 'Female', 'Hindlimb', 'Male', 'Muscle, Skeletal', 'Neoplasms', 'Reconstructive Surgical Procedures', 'Retrospective Studies', 'Surgical Flaps'] | 30,410,175 | [['A01.923.047.050'], ['B01.050'], ['C22.180'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['C22.268'], ['B01.050.150.900.649.313.750.250.216.200'], ['A13.473'], ['A02.633.567', 'A10.690.552.500'], ['C04'], ['E04.680'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715... | ['Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
First-event or marginal estimation of cause-specific hazards for analysing correlated multivariate failure-time data? | In the analysis of multivariate failure-time data, the effect of a treatment or an exposure on the hazard of each failure type is sometimes evaluated using only the information on the first event that occurs in every individual, ignoring all events that follow. A Cox proportional hazards model may be fitted to such dat... | ['Antineoplastic Combined Chemotherapy Protocols', 'Disease-Free Survival', 'Europe', 'Humans', 'Likelihood Functions', 'Multivariate Analysis', 'Osteosarcoma', 'Proportional Hazards Models', 'Randomized Controlled Trials as Topic', 'Risk', 'Risk Assessment', 'Survival Analysis'] | 17,551,931 | [['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['E01.789.800.190', 'E05.318.740.998.300', 'N04.761.559.590.800.190', 'N05.715.360.575.575.800.190', 'N05.715.360.750.795.300', 'N06.850.520.830.998.300'], ['Z01.542'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.475', 'E05.318.740.600.4... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Joint modeling of genetic association and population stratification using latent class models. | We show how latent class log-linear models can be used to test for an association between a candidate gene and a disease phenotype in a stratified population when the stratification is unobserved. The stratification may arise because of several ethnic groups or immigration and may lead to spurious associations between ... | ['Case-Control Studies', 'Genetic Predisposition to Disease', 'Genetics, Population', 'Genotype', 'Humans', 'Linear Models', 'Models, Genetic', 'Phenotype', 'Polymorphism, Single Nucleotide'] | 11,793,709 | [['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['C23.550.291.687.500', 'G05.380.355'], ['H01.158.273.343.335'], ['G05.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.500', 'E05.318.740.750.425', 'E05.599.835.750', 'N05.715.360.750.530.460', 'N05.715.360.750.695... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Italian translation, cultural adaptation and validation of KDQOL-SF, version 1.3, in patients with severe renal failure. | BACKGROUND: This study aims to confirm the reliability and validity of the KDQOL-SF in its Italian version. Cultural adaptation of such an instrument to assess quality of life of patients with chronic kidney disease is a major challenge.METHODS: The instrument was translated according to the translation algorithm. A tr... | ['Acculturation', 'Adult', 'Algorithms', 'Female', 'Health Surveys', 'Humans', 'Italy', 'Kidney Failure, Chronic', 'Language', 'Male', 'Middle Aged', 'Patient Satisfaction', 'Psychometrics', 'Quality of Life', 'Renal Dialysis', 'Reproducibility of Results', 'Severity of Illness Index'] | 17,347,972 | [['I01.076.201.450.050', 'I01.880.853.100.079'], ['M01.060.116'], ['G17.035', 'L01.224.050'], ['E05.318.308.980.438', 'N05.715.360.300.800.438', 'N06.850.520.308.980.438'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.542.489'], ['C12.777.419.780.750.500', 'C13.351.968.419.780.750.500'], ['F01.145.209.399', '... | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Diseases [C]', 'Psychiatry and Psychology [F]',... | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
[Travelers attending an international vaccine center. Is the risk for the pediatric traveler increasing?]. | INTRODUCTION: There is a perception that the number of pediatric travelers is increasing, mainly due to the so-called visiting friends and relatives (VFRs) group. Both the demographic and trips characteristics in this group may lead to an increased risk and a greater complexity in vaccinations and other preventive reco... | ['Child', 'Child, Preschool', 'Cross-Sectional Studies', 'Family', 'Friends', 'Humans', 'Internationality', 'Risk Assessment', 'Time Factors', 'Travel', 'Vaccination'] | 23,402,777 | [['M01.060.406'], ['M01.060.406.448'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['F01.829.263', 'I01.880.853.150'], ['M01.252'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I01.615'], ['E05.318.740.600.800.715', 'N04.452.871.715', 'N05.715.360.750.625.700.690', 'N06.850.505.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
BRCA1/2 genetic testing in the community setting. | PURPOSE: BRCA1/2 genetic testing has been commercially available in the United States since 1996. Most published reports described BRCA1/2 testing as research studies at large academic centers, but less is known about testing in the community. This study evaluates the process and early outcomes of BRCA1/2 genetic testi... | ['Adult', 'Breast Neoplasms', 'Counseling', 'Female', 'Genes, BRCA1', 'Genes, BRCA2', 'Genetic Predisposition to Disease', 'Genetic Testing', 'Germ-Line Mutation', 'Humans', 'Medical History Taking', 'Middle Aged', 'Risk Factors', 'Surveys and Questionnaires', 'United States'] | 12,431,973 | [['M01.060.116'], ['C04.588.180', 'C17.800.090.500'], ['F02.784.176', 'F04.408.413', 'N02.421.143.303', 'N02.421.461.363'], ['G05.360.340.024.340.375.249.100', 'G05.360.340.024.340.415.400.100'], ['G05.360.340.024.340.375.249.105', 'G05.360.340.024.340.415.400.105'], ['C23.550.291.687.500', 'G05.380.355'], ['E01.370.22... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Effect of methamphetamine on the pharmacokinetics of dextromethorphan and midazolam in rats. | Methamphetamine is the fourth most frequently reported compound associated with drug abuse on admission of patients to treatment centres after cocaine, heroin and marijuana. It is metabolized in the organism with a reaction that is catalyzed by cytochrome P450, mainly by the CYP2D and CYP3A subfamily, 4-hydroxyamphetam... | ['Alcohol Oxidoreductases', 'Animals', 'Aryl Hydrocarbon Hydroxylases', 'Cytochrome P-450 CYP3A', 'Cytochrome P450 Family 2', 'Dextromethorphan', 'Drug Interactions', 'Male', 'Methamphetamine', 'Midazolam', 'Oxidoreductases, N-Demethylating', 'Rats', 'Rats, Wistar'] | 16,250,257 | [['D08.811.682.047'], ['B01.050'], ['D08.244.453.005', 'D08.811.682.690.708.170.010', 'D12.776.422.220.453.010'], ['D08.244.453.860.500', 'D08.811.682.662.582.353', 'D08.811.682.690.708.170.495.500', 'D12.776.422.220.453.860.500'], ['D08.244.453.491', 'D08.811.682.690.708.170.450', 'D12.776.422.220.453.491'], ['D03.132... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
MR imaging of pulmonary parenchyma: comparison with CT in evaluating cadaveric lung specimens. | Magnetic resonance (MR) images (0.5 and 1.5 T) and thin section CT scans were obtained in 17 cadaveric lungs (11 fixed, 6 both pre and post fixation). Standard T1-weighted spin echo (SE) sequences were used for all lungs. In six lungs, additional gradient-refocused echo (GRE) sequences were also obtained. The MR images... | ['Cadaver', 'Humans', 'Lung', 'Lung Diseases', 'Magnetic Resonance Imaging', 'Tomography, X-Ray Computed'] | 2,370,359 | [['C23.550.260.224'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A04.411'], ['C08.381'], ['E01.370.350.825.500'], ['E01.370.350.350.810', 'E01.370.350.600.350.700.810', 'E01.370.350.700.700.810', 'E01.370.350.700.810.810', 'E01.370.350.825.810.810']] | ['Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Delirium motor subtypes in elderly hip fracture patients: risk factors, outcomes and longitudinal stability. | OBJECTIVE: Delirium is often accompanied by changes in motor activity but the longitudinal expression of these features and etiological and prognostic significance of clinical subtypes defined by motor activity is unclear.METHODS: This is a prospective cohort study of elderly patients undergoing hip fracture surgery. B... | ['APACHE', 'Activities of Daily Living', 'Aged, 80 and over', 'Cohort Studies', 'Delirium', 'Female', 'Hip Fractures', 'Humans', 'Longitudinal Studies', 'Male', 'Mental Status Schedule', 'Motor Activity', 'Netherlands', 'Postoperative Complications', 'Prognosis', 'Prospective Studies', 'Risk Factors'] | 23,597,334 | [['E05.318.308.980.438.475.365', 'E05.318.308.980.438.475.456.500.250', 'N05.715.360.300.800.438.375.364.500.250', 'N06.850.520.308.980.438.475.364.500.250'], ['E02.760.169.063.500.067', 'E02.831.067', 'I03.050', 'N02.421.784.110'], ['M01.060.116.100.080'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.52... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Efficacy and safety of tacrolimus in induction therapy of patients with lupus nephritis. | Background: The purpose of this study was to detect the efficacy and safety of tacrolimus (TAC) in induction therapy of patients with lupus nephritis.Methods: Associated studies were extracted from the PubMed and the Cochrane Library on July 10, 2018, and applicable investigations were pooled and analyzed by meta-analy... | ['Humans', 'Immunosuppressive Agents', 'Lupus Nephritis', 'Tacrolimus'] | 30,880,918 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.477.656'], ['C12.777.419.570.363.680', 'C13.351.968.419.570.363.680', 'C17.300.480.680', 'C20.111.590.560'], ['D02.540.505.810']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Hypogastric artery ligation. Safety and efficacy of a training program]. | Bilateral hypogastric artery ligation is a technique described in the antiquity to restrain the hemorrhage in the gynecological and obstetric surgery. There are few Gineco-obstetricians that dominate the technique, for what intended a training program, in which was to demonstrate their security and effectiveness. We ca... | ['Clinical Competence', 'Female', 'Gynecology', 'Humans', 'Iliac Artery', 'Ligation', 'Obstetrics', 'Surveys and Questionnaires'] | 11,824,103 | [['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['H02.403.763.750', 'H02.403.810.310'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A07.015.114.444'], ['E04.426'], ['H02.403.810.450'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980']] | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 |
Temporal shifts and temperature sensitivity of avian spring migratory phenology: a phylogenetic meta-analysis. | There are wide reports of advances in the timing of spring migration of birds over time and in relation to rising temperatures, though phenological responses vary substantially within and among species. An understanding of the ecological, life-history and geographic variables that predict this intra- and interspecific ... | ['Animal Migration', 'Animals', 'Birds', 'Climate Change', 'Phylogeny', 'Seasons', 'Temperature'] | 27,859,281 | [['F01.145.113.069.500'], ['B01.050'], ['B01.050.150.900.248'], ['G16.500.175.374'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['G01.910.645.661', 'G16.500.275.071.590', 'N06.230.300.100.250.525'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.150.450', 'N06.230.300.100.725.710']] | ['Psychiatry and Psychology [F]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Safety Outcomes of Atorvastatin 80 mg Versus Atorvastatin 40 mg in a Veteran Population. | Background: High-intensity atorvastatin dosing may lead to a greater incidence of adverse events, subsequently leading to discontinuation and suboptimal risk reduction for major adverse cardiovascular events. No previous studies exist investigating the safety of high-intensity atorvastatin therapy among a veteran popul... | ['Aged', 'Atorvastatin', 'Dose-Response Relationship, Drug', 'Female', 'Humans', 'Hydroxymethylglutaryl-CoA Reductase Inhibitors', 'Incidence', 'Lipids', 'Male', 'Middle Aged', 'Muscle Weakness', 'Myalgia', 'Retrospective Studies', 'Veterans'] | 31,544,472 | [['M01.060.116.100'], ['D03.383.129.578.075', 'D10.251.450.200'], ['G07.690.773.875', 'G07.690.936.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.519.186.071.202.370', 'D27.505.519.389.370', 'D27.505.954.557.500.202.370'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.37... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Increased incidence of alcohol-related deaths from accidents and violence in subjects with ankylosing spondylitis. | Subjects with ankylosing spondylitis (AS) have an increased incidence of deaths from accidents and violence, which is due in part, but perhaps not entirely, to the vulnerability of the affected spine to fractures. The present study covered all the 71 subjects (58 men and 13 women) who had died in Finland in 1989 and wh... | ['Accidents', 'Adult', 'Aged', 'Aged, 80 and over', 'Alcohol Drinking', 'Cause of Death', 'Cohort Studies', 'Female', 'Finland', 'Humans', 'Incidence', 'Male', 'Middle Aged', 'Registries', 'Spondylitis, Ankylosing', 'Violence'] | 9,667,625 | [['N06.850.135'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['F01.145.317.269'], ['E05.318.308.985.550.250', 'N01.224.935.698.100', 'N06.850.505.400.975.550.250', 'N06.850.520.308.985.550.250'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['Z01.542.816.186'], ['B0... | ['Health Care [N]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Organisms [B]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Ease of use of tobramycin inhalation powder compared with nebulized tobramycin and colistimethate sodium: a crossover study in cystic fibrosis patients with pulmonary Pseudomonas aeruginosa infection. | BACKGROUND: This study assessed the ease of use of tobramycin inhalation powder (TIP) administered via T-326 inhaler versus tobramycin inhalation solution (TIS) and colistimethate sodium (COLI), both administered via nebulizers, for the treatment of chronic pulmonary Pseudomonas aeruginosa infection in patients with cy... | ['Administration, Inhalation', 'Adolescent', 'Adult', 'Anti-Bacterial Agents', 'Child', 'Colistin', 'Cross-Over Studies', 'Cystic Fibrosis', 'Equipment Contamination', 'Equipment Design', 'Europe', 'Female', 'Forced Expiratory Volume', 'Humans', 'Lung', 'Male', 'Nebulizers and Vaporizers', 'Patient Satisfaction', 'Powd... | 28,614,995 | [['E02.319.267.050'], ['M01.060.057'], ['M01.060.116'], ['D27.505.954.122.085'], ['M01.060.406'], ['D04.345.566.780.110', 'D10.477.750.110', 'D12.644.050.600.110', 'D12.644.641.780.110', 'D12.776.543.695.054.600.110'], ['E05.318.370.150', 'N05.715.360.325.150', 'N06.850.520.445.150'], ['C06.689.202', 'C08.381.187', 'C1... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Diseases [C]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Cytoskeleton of human mononuclear cells as a possible peripheral marker for phenylalanine neurotoxicity in PKU. | In this work we tested human mononuclear cells as a peripheral marker to study neurotoxicity of phenylalanine (Phe). Slices of cerebral cortex of rats or human mononuclear cells were incubated with different concentrations of Phe and/or Ala in the presence of 32P-orthophosphate, the cytoskeletal fraction was extracted,... | ['Animals', 'Biomarkers', 'Cytoskeleton', 'Electrophoresis, Polyacrylamide Gel', 'Humans', 'In Vitro Techniques', 'Monocytes', 'Phenylalanine', 'Phenylketonurias', 'Rats', 'Rats, Wistar'] | 12,515,306 | [['B01.050'], ['D23.101'], ['A11.284.430.214.190.750'], ['E05.196.401.402', 'E05.301.300.319'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.481'], ['A11.118.637.555.652', 'A11.148.580', 'A11.627.624', 'A11.733.547', 'A15.145.229.637.555.652', 'A15.378.316.580', 'A15.382.490.555.652', 'A15.382.670.547', 'A15.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endobronchial polyp derived from a myxosarcoma in the lung of a dog. | An endobronchial polyp was visible radiographically and bronchoscopically in an 11-year-old, mixed-breed dog with a persistent cough. The polyp was removed by traction. Initial histological examination suggested it was a myxomatous fibroma. The cough resolved but recurred with polyp regrowth. Two additional lung masses... | ['Animals', 'Bronchoscopy', 'Dog Diseases', 'Dogs', 'Fatal Outcome', 'Lung Neoplasms', 'Male', 'Myxosarcoma', 'Neoplasm Recurrence, Local', 'Polyps', 'Pulmonary Surgical Procedures', 'Radiography'] | 18,981,198 | [['B01.050'], ['E01.370.386.105', 'E01.370.388.250.100', 'E04.502.250.100', 'E04.928.600.080'], ['C22.268'], ['B01.050.150.900.649.313.750.250.216.200'], ['E05.318.308.985.550.325', 'N01.224.935.698.201', 'N06.850.505.400.975.550.325', 'N06.850.520.308.985.550.325'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
An auxin maximum in the middle layer controls stamen development and pollen maturation in Arabidopsis. | Here, we investigated the role of auxin distribution in controlling Arabidopsis thaliana late stamen development. We analysed auxin distribution in anthers by monitoring DR5 activity: at different flower developmental stages; inhibiting auxin transport; in the rpk2-3 and ems1 mutants devoid of middle layer (ML) or tape... | ['Arabidopsis', 'Arabidopsis Proteins', 'Biological Transport', 'Gene Expression Regulation, Plant', 'Genes, Plant', 'Genes, Reporter', 'Indoleacetic Acids', 'Models, Biological', 'Organ Specificity', 'Pollen', 'RNA, Messenger', 'Transcription Factors'] | 27,659,765 | [['B01.650.940.800.575.912.250.157.100'], ['D12.776.765.149'], ['G03.143'], ['G05.308.375'], ['G05.360.340.024.340.393', 'G05.360.340.365.500'], ['G05.360.340.024.340.435'], ['D03.066.288', 'D03.633.100.473.404'], ['E05.599.395'], ['G07.650'], ['A18.024.249.500.249.500'], ['D13.444.735.544'], ['D12.776.930']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
General practitioner knowledge of prohibited substances in sport. | OBJECTIVES: To assess general practitioner knowledge of banned substances in sport.METHODS: Postal questionnaire sent to all general practitioners in West Sussex.RESULTS: Only 55 (35%) of those who responded (157 in total) were aware that guidelines are to be found in the British National Formulary, and 19 (12%) of res... | ['Doping in Sports', 'Family Practice', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Practice Guidelines as Topic', 'Surveys and Questionnaires', 'United Kingdom'] | 9,192,126 | [['I01.880.735.265'], ['H02.403.340.500'], ['F01.100.150.500', 'N05.300.150.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N04.761.700.350.650', 'N05.700.350.650'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980'], ['Z01.542.363']] | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Disciplines and Occupations [H]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 |
Genome-wide analysis of copy number variations reveals that aging processes influence body fat distribution in Korea Associated Resource (KARE) cohorts. | Many anthropometric measures, including body mass index (BMI), waist-to-hip ratio (WHR), and subcutaneous fat thickness, are used as indicators of nutritional status, fertility and predictors of future health outcomes. While BMI is currently the best available estimate of body adiposity, WHR and skinfold thickness at v... | ['Adiposity', 'Adult', 'Aged', 'Aging', 'Body Fat Distribution', 'Body Mass Index', 'DNA Copy Number Variations', 'Female', 'Genome, Human', 'Genome-Wide Association Study', 'Humans', 'Male', 'Middle Aged', 'Obesity', 'Phenotype', 'Polymorphism, Single Nucleotide', 'Republic of Korea', 'Skinfold Thickness', 'Waist-Hip ... | 22,825,314 | [['E01.370.600.115.100.062.500', 'G02.111.130.134.500', 'G03.180.134.500', 'G07.100.049.134.500'], ['M01.060.116'], ['M01.060.116.100'], ['G07.345.124'], ['E01.370.600.115.100.062', 'G02.111.130.134', 'G03.180.134', 'G07.100.049.134'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.1... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Foot reconstruction using vascularised fibula. | Vascularised fibula has been used to treat three patients with skin-bone defects of the foot following severe trauma. Similarity between fibula and metatarsal bone is obvious and makes fibula an ideal choice in the replacement of defects in the first metatarsal. Depending on the size of soft tissue defects, different c... | ['Adolescent', 'Bone Wires', 'Child', 'Fibula', 'Foot Injuries', 'Humans', 'Leg Injuries', 'Male', 'Metatarsal Bones', 'Skin Transplantation', 'Surgical Flaps'] | 8,101,124 | [['M01.060.057'], ['E07.695.370.468', 'E07.858.442.660.460.468', 'E07.858.690.725.460.468'], ['M01.060.406'], ['A02.835.232.043.650.321'], ['C26.558.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C26.558'], ['A02.835.232.043.300.492'], ['E02.095.147.725.700', 'E04.680.275.850', 'E04.936.580.700'], ['A10.850.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Life-Space Predicts Health Care Utilization in Community-Dwelling Older Adults. | OBJECTIVE: To determine whether decline in life-space mobility predicts increased health care utilization among community-dwelling older adults.METHOD: Health care utilization (number of emergency department [ED] visits and hospitalizations) was self-reported during monthly interviews among 419 community-dwelling Afric... | ['African Americans', 'Aged', 'Comorbidity', 'Emergency Service, Hospital', 'European Continental Ancestry Group', 'Female', 'Hospitalization', 'Humans', 'Independent Living', 'Male', 'Mobility Limitation', 'Patient Acceptance of Health Care', 'Residence Characteristics', 'Self Report', 'United States'] | 29,254,407 | [['M01.686.508.100.100', 'M01.686.754.100'], ['M01.060.116.100'], ['N05.715.350.225', 'N06.850.490.687'], ['N02.278.216.500.968.336', 'N02.421.297.195', 'N04.452.442.452.422.336'], ['M01.686.508.400'], ['E02.760.400', 'N02.421.585.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I03.050.500', 'N01.224.791.550'... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Single-incision laparoscopic hepatectomy for benign and malignant hepatopathy: initial experience in 8 Chinese patients. | BACKGROUND: The single-incision laparoscopic surgery (SILS) technique has been used in many surgical procedures, but there are few reports regarding liver surgeries. The purpose of this study was to perform single-incision laparoscopic hepatectomy (SILH) using standard laparoscopic instrumentation in 8 Chinese patients... | ['Abdomen', 'Adult', 'Aged', 'China', 'Female', 'Hepatectomy', 'Humans', 'Laparoscopy', 'Liver Diseases', 'Male', 'Middle Aged', 'Postoperative Care', 'Radiography, Abdominal', 'Tomography, X-Ray Computed'] | 22,474,017 | [['A01.923.047'], ['M01.060.116'], ['M01.060.116.100'], ['Z01.252.474.164'], ['E04.210.556'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.388.250.520', 'E04.502.250.520'], ['C06.552'], ['M01.060.116.630'], ['E02.760.731.700', 'E04.604.500', 'N02.421.585.722.700'], ['E01.370.350.700.715'], ['E01.370.350.3... | ['Anatomy [A]', 'Named Groups [M]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
[Risk factors and prognostics of nosocomial infectionof surgical wounds in a general hospital]. | Surgical infections due to gram-negative bacteria are important because of their high frequency, morbidity and mortality. In order to evaluate the risk factors and prognostics of gram-negative surgical wound infections a group of 50 patients with surgical infections were studied prospectively and consecutively and were... | ['Cross Infection', 'Female', 'Gram-Negative Bacterial Infections', 'Hospitals, General', 'Humans', 'Male', 'Middle Aged', 'Prognosis', 'Prospective Studies', 'Risk Factors', 'Spain', 'Surgical Wound Infection'] | 11,086,278 | [['C01.248', 'C23.550.291.875.500'], ['C01.150.252.400'], ['N02.278.421.389'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.789'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['E05.318.740.600.800.725', 'N05.715.350.200.700', 'N05.715.360.750... | ['Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Do different reperfusion methods affect the outcomes of stroke induced by MCAO in adult rats? | There are two patterns of ischemia/reperfusion (I/R) models used in rat middle cerebral artery occlusion (MCAO) I/R models, which differ in the use of unilateral or bilateral carotid artery reperfusion. The primary difference between the two patterns of I/R models is the complexity of the surgery procedure. However, re... | ['Animals', 'Brain-Derived Neurotrophic Factor', 'Disease Models, Animal', 'Infarction, Middle Cerebral Artery', 'Male', 'Rats', 'Rats, Sprague-Dawley', 'Reperfusion Injury', 'Stroke'] | 26,268,737 | [['B01.050'], ['D12.644.276.860.100', 'D12.776.467.860.100', 'D12.776.631.600.100', 'D23.529.850.100'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['C10.228.140.300.150.477.200.450', 'C10.228.140.300.510.200.387', 'C10.228.140.300.775.200.200.450', 'C14.907.253.092.477.200.450', 'C14.907.253.560.200.387', 'C14.907.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Biological evaluation of a novel copper-containing composite for contraception. | OBJECTIVE: To investigate the biocompatibility of a novel copper-containing composite to provide preclinical data for clinical application of intrauterine device (IUD) or intra-vas device (IVD).DESIGN: Prospective experimental study.SETTING: Good laboratory practices laboratories.ANIMALS: Twenty healthy adult mice (SPF... | ['Animals', 'Cells, Cultured', 'Contraception', 'Female', 'Intrauterine Devices, Copper', 'Mice', 'Prospective Studies', 'Rabbits'] | 20,627,240 | [['B01.050'], ['A11.251'], ['E02.875.194'], ['E07.190.250.510.520.300'], ['B01.050.150.900.649.313.992.635.505.500'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['B01.050.150.900.649.313.968.700']] | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Availability of the inner surface of the red cell membrane to antibodies in digitonin ghosts. Studies on D-negative cells with anti-D. | Studies were done to determine whether antibodies can detect antigens on the inner red cell stromal membrane. When albumin, anti-A, anti-D, or IgG were combined with varying volumes of intact O, Rh-negative red cells (RBCs), these proteins diluted, on the average, to 76 percent of the total volume, which was almost ide... | ['Digitonin', 'Erythrocyte Membrane', 'Humans', 'Rh-Hr Blood-Group System', 'Ultracentrifugation'] | 3,927,532 | [['D04.210.500.155.580.130.500.236', 'D09.408.180.261.236'], ['A11.118.290.270', 'A11.284.149.356', 'A15.145.229.334.270'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D23.050.301.290.775', 'D23.050.705.230.775'], ['E05.181.724', 'E05.196.941']] | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
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