Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Food Protein Based Core-Shell Nanocarriers for Oral Drug Delivery: Effect of Shell Composition on in Vitro and in Vivo Functional Performance of Zein Nanocarriers. | The study was aimed at systematically investigating the influence of shell composition on the particle size, stability, release, cell uptake, permeability, and in vivo gastrointestinal distribution of food protein based nanocarriers for oral delivery applications. Three different core-shell nanocarriers were prepared u... | ['Animals', 'Caco-2 Cells', 'Cell Line, Tumor', 'Chemistry, Pharmaceutical', 'Drug Carriers', 'Drug Delivery Systems', 'Female', 'Food', 'Humans', 'Hydrophobic and Hydrophilic Interactions', 'Male', 'Mice, Inbred BALB C', 'Micelles', 'Nanoparticles', 'Particle Size', 'Polyethylene Glycols', 'Proteins', 'Rats', 'Rats, S... | 28,103,046 | [['B01.050'], ['A11.251.210.190.160', 'A11.251.860.180.160', 'A11.436.140'], ['A11.251.210.190', 'A11.251.860.180'], ['H01.158.703.007', 'H01.181.466'], ['D26.255.260', 'E02.319.300.380'], ['E02.319.300'], ['G07.203.300', 'J02.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.409'], ['B01.050.050.199.520.52... | ['Organisms [B]', 'Anatomy [A]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Simian rotavirus SA11 replication in cell cultures. | Understanding the basic virology of rotavirus infections has been hampered by the fastidiousness of most isolates and by the lack of a rapid quantitative assay method. The growth characteristics of the simian rotavirus SA11 were studied because it grows to high titers in tissue culture and infectivity can be quantitate... | ['Animals', 'Cell Line', 'Culture Media', 'Cytopathogenic Effect, Viral', 'Haplorhini', 'Kidney', 'Macaca mulatta', 'RNA Viruses', 'Rotavirus', 'Temperature', 'Virus Cultivation', 'Virus Replication'] | 229,253 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Influence of the preconception maternal nutritional status on fetal growth and development in rats]. | A study was carried out in Wistar female rats to determine the influence of maternal preconceptional undernutrition on fetal growth and maternal-fetal exchange of energy and nitrogen retained by pregnant rats, with and without supplementary feeding, in comparison to a control group. Experimental malnourished female rat... | ['Animals', 'Dietary Proteins', 'Energy Metabolism', 'Female', 'Fetus', 'Food, Fortified', 'Gestational Age', 'Maternal-Fetal Exchange', 'Pregnancy', 'Protein-Energy Malnutrition', 'Rats', 'Rats, Inbred Strains'] | 6,800,319 | [['B01.050'], ['D12.776.256', 'G07.203.300.428', 'J02.500.428'], ['G03.295'], ['A16.378'], ['G07.203.300.515', 'J02.500.515'], ['G07.345.500.325.235.968', 'G08.686.320'], ['G08.686.784.769.455'], ['G08.686.784.769'], ['C18.654.521.500.708.626'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760', '... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Small-cell lung cancer (SCLC) cell adhesion on E- and P-selectin under physiological flow conditions. | Hematogenous metastasis is still a poorly understood phenomenon. The rate-limiting step within the metastatic cascade is not yet clear although it may be estimated that the extravasation of circulating tumor cells is a step of crucial importance, as most tumor cells that are shed into circulation undergo apoptosis. The... | ['Animals', 'Cattle', 'Cell Adhesion', 'Cell Culture Techniques', 'Cell Line, Tumor', 'E-Selectin', 'Humans', 'Lung Neoplasms', 'P-Selectin', 'Rheology', 'Serum Albumin, Bovine', 'Small Cell Lung Carcinoma'] | 24,092,431 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['G04.022'], ['E01.370.225.500.223', 'E05.200.500.265', 'E05.242.223', 'E05.481.500.249'], ['A11.251.210.190', 'A11.251.860.180'], ['D12.776.395.550.200.700.300', 'D12.776.503.843.300', 'D12.776.543.550.200.700.300', 'D23.050.301.350.700.300'], ['B01.050.150.900.64... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Proximal and distal regulatory elements that influence in vivo expression of a cell cycle-dependent human H4 histone gene. | We have examined the sequences required in vivo to promote transcription of a cell cycle-regulated human H4 histone gene. Deletion mutants of the 5' flanking region were assayed in mouse cells or fused with the chloramphenicol acetyltransferase (CAT) gene for assay in HeLa cells. The functional limits of the regulatory... | ['Animals', 'Cell Cycle', 'Cell Line', 'Chromosome Deletion', 'Cloning, Molecular', 'Genes', 'Genes, Regulator', 'HeLa Cells', 'Histones', 'Humans', 'L Cells', 'Mice', 'Mutation', 'Plasmids', 'RNA, Messenger', 'Thymidine Kinase', 'Transcription, Genetic'] | 3,473,491 | [['B01.050'], ['G04.144'], ['A11.251.210'], ['C23.550.210.050.500.500', 'G05.365.590.029.530.175', 'G05.365.590.175.050.500.500', 'G05.365.590.762.180', 'G05.558.800.180', 'G05.700.131.500.500'], ['E05.393.220'], ['G05.360.340.024.340'], ['G05.360.340.024.340.425'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.4... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Membranoproliferative glomerulonephritis associated with low-grade B cell lymphoma presenting in the kidney. | Low-grade B cell lymphoma of mucosa-associated tissue type (MALToma) rarely may involve the kidney. Membranoproliferative glomerulonephritis (MPGN) is an uncommon complication of B cell lymphoma and may be related to cryoglobulin and/or immunoglobulin synthesis by a secretory B cell clone. We report 2 patients with the... | ['Aged', 'Biopsy', 'Diagnosis, Differential', 'Female', 'Glomerulonephritis, Membranoproliferative', 'Humans', 'Kidney', 'Kidney Neoplasms', 'Lymphoma, B-Cell', 'Male', 'Severity of Illness Index'] | 12,005,247 | [['M01.060.116.100'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['E01.171'], ['C12.777.419.570.363.615', 'C13.351.968.419.570.363.615', 'C20.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A05.810.453'], ['C04... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Why can patients with baker's asthma tolerate wheat flour ingestion? Is wheat pollen allergy relevant? | Diagnosis in patients sensitised to multiple pollens is difficult due to the relationship between pollen and food allergens. Misdiagnosis is often a cause for unsuccessful specific immunotherapy. Wheat is a potent allergen source and is one of the causes of baker's asthma, food and pollen allergy. Recently, we have per... | ['Allergens', 'Asthma', 'Eating', 'Flour', 'Humans', 'Pollen', 'Rhinitis, Allergic, Seasonal', 'Triticum', 'Wheat Hypersensitivity'] | 19,775,798 | [['D23.050.063'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['G07.203.650.283', 'G10.261.330'], ['G07.203.300.484', 'J02.500.484'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A18.024.249.500.249.500'], ['C08.460.799.315.750', 'C08.674.453.750', 'C09.603.799.315.750', 'C20.543.480... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Relationships among alcohol consumption, facial flushing response, and metabolic syndrome in healthy men. | PURPOSE: It is believed that alcohol has an intimate connection with metabolic syndrome (MS). However, the role of facial flushing after alcohol consumption in this relationship has not yet been well known. We explored the relationship between weekly alcohol consumption, risk of MS, and the flushing response.METHODS: T... | ['Adult', 'Alcohol Drinking', 'Asian Continental Ancestry Group', 'Blood Glucose', 'Blood Pressure', 'Cross-Sectional Studies', 'Flushing', 'Humans', 'Logistic Models', 'Male', 'Metabolic Syndrome', 'Middle Aged', 'Regression Analysis', 'Retrospective Studies', 'Risk'] | 22,575,812 | [['M01.060.116'], ['F01.145.317.269'], ['M01.686.508.200'], ['D09.947.875.359.448.500'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['C23.888.885.344'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.525', 'E05.318.740.6... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Autophagy contributes to therapy-induced degradation of the PML/RARA oncoprotein. | Treatment of acute promyelocytic leukemia (APL) with all-trans retinoic acid and/or arsenic trioxide represents a paradigm in targeted cancer therapy because these drugs cause clinical remission by affecting the stability of the fusion oncoprotein promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARA). The au... | ['Arsenic Trioxide', 'Arsenicals', 'Autophagy', 'Cell Differentiation', 'Cell Line, Tumor', 'HeLa Cells', 'Humans', 'Intracellular Signaling Peptides and Proteins', 'Leukemia, Promyelocytic, Acute', 'Nuclear Proteins', 'Oncogene Proteins, Fusion', 'Oxides', 'Promyelocytic Leukemia Protein', 'Protein-Serine-Threonine Ki... | 20,574,048 | [['D01.075.038', 'D01.650.550.125'], ['D01.075', 'D02.129'], ['G04.011'], ['G04.152'], ['A11.251.210.190', 'A11.251.860.180'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.360', 'D12.776.476'], ['C04.557.337.539.275.700'], ['D12.776.660'], ['D... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Extraosseous Extension of Aggressive Vertebral Hemangioma as a Potential Pitfall on 68Ga-PSMA PET/CT. | A 74-year-old man with newly diagnosed prostate cancer underwent Ga-PSMA PET/CT, which demonstrated intense uptake in and adjacent the L2 vertebral body. Subsequent MRI of the lumbar spine showed an aggressive L2 hemangioma with adjacent soft tissue extension. There was congruence of the intraosseous and extraosseous c... | ['Aged', 'Edetic Acid', 'Hemangioma', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Oligopeptides', 'Positron Emission Tomography Computed Tomography', 'Prostatic Neoplasms', 'Spine'] | 28,632,693 | [['M01.060.116.100'], ['D02.092.782.258.368.250', 'D02.241.081.018.253'], ['C04.557.645.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['D12.644.456'], ['E01.370.350.350.800.700.500', 'E01.370.350.350.810.645', 'E01.370.350.567.500', 'E01.370.350.600.350.700.810.490', 'E01.370.350.600.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Chemotaxis of granulocytes across bovine pulmonary artery intimal explants without endothelial cell injury. | Emigration of granulocytes from vessel lumen to a site of injury is a hallmark of acute inflammation but whether this migration is necessarily associated with vascular damage is not clear. To follow the structural changes associated with granulocyte migration across an intact endothelial cell layer and to assess change... | ['Animals', 'Capillary Permeability', 'Cattle', 'Chemotaxis, Leukocyte', 'Diffusion', 'Endothelium', 'Granulocytes', 'Leukocyte Count', 'Microscopy, Electron, Scanning', 'Pulmonary Artery', 'Zymosan'] | 6,701,890 | [['B01.050'], ['G03.143.330', 'G09.330.165'], ['B01.050.150.900.649.313.500.380.271'], ['G04.198.424.233'], ['G01.202', 'G02.196'], ['A10.272.491'], ['A11.118.637.415', 'A11.148.350', 'A11.627.340', 'A15.145.229.637.415', 'A15.378.316.340', 'A15.382.490.315'], ['E01.370.225.500.195.107.595', 'E01.370.225.625.107.595', ... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Three-dimensional Evaluation of Nasal Surgery in Patients with Obstructive Sleep Apnea. | BACKGROUND: Obstructive sleep apnea (OSA) is a common sleep disorder and is characterized by airway collapse at multiple levels of upper airway. The effectiveness of nasal surgery has been discussed in several studies and shows a promising growing interest. In this study, we intended to evaluate the effects of nasal su... | ['Adult', 'Cone-Beam Computed Tomography', 'Female', 'Humans', 'Imaging, Three-Dimensional', 'Male', 'Middle Aged', 'Nasal Surgical Procedures', 'Quality of Life', 'Sleep Apnea, Obstructive'] | 26,960,367 | [['M01.060.116'], ['E01.370.350.700.810.810.490', 'E01.370.350.825.810.810.399'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.400', 'L01.224.308.410'], ['M01.060.116.630'], ['E04.580.392'], ['I01.800', 'K01.752.400.750', 'N06.850.505.400.425.837'], ['C08.618.085.852.850', 'C10.886.425.800.750.850']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Information Science [L]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 0 |
Interleukin-37 Inhibits the Imbalance Between T Helper 17 Cells and Regulatory T Cells in Hand, Foot, and Mouth Disease. | The aim of this study was to explore the role of interleukin-37 (IL-37) in imbalance of T helper (Th)17/regulatory T cells (Tregs) in hand, foot, and mouth disease (HFMD). The proportions of CD4+ IL-17A+ Th17 cells and CD4+ CD25+Foxp3+ Tregs in peripheral blood or peripheral blood mononuclear cells (PBMCs) from HFMD pa... | ['Child', 'Child, Preschool', 'China', 'Female', 'Hand, Foot and Mouth Disease', 'Humans', 'Interleukin-1', 'Male', 'T-Lymphocytes, Regulatory', 'Th17 Cells'] | 31,090,483 | [['M01.060.406'], ['M01.060.406.448'], ['Z01.252.474.164'], ['C01.925.782.687.359.213.331'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.465.010', 'D12.644.276.374.500.400', 'D12.776.467.374.465.010', 'D12.776.467.374.500.400', 'D23.529.374.465.131', 'D23.529.374.500.400'], ['A11.118.637.555.567.... | ['Named Groups [M]', 'Geographicals [Z]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
Effect of chronic dietary nitrate and different iodine supply on porcine thyroid function, somatomedin-C-level and growth. | Due to the lately increased oral nitrate intake of humans and animals the influence of 3% KNO3 in the diet on growth and the thyroid hormone and somatomedin-C-concentration in the serum was to be tested in an experiment with growing pigs in case of different iodine supply. The investigations were undertaken in 3 groups... | ['Animals', 'Diet', 'Growth', 'Insulin-Like Growth Factor I', 'Iodine', 'Nitrates', 'Somatomedins', 'Swine', 'Thyroid Gland', 'Thyroid Hormones'] | 3,556,413 | [['B01.050'], ['G07.203.650.240'], ['G07.345.249'], ['D12.644.276.937.400', 'D12.776.124.862.400', 'D12.776.467.937.400', 'D23.529.937.400'], ['D01.268.380.400'], ['D01.248.497.158.606', 'D01.625.525.550', 'D02.583'], ['D12.644.276.937', 'D12.776.124.862', 'D12.776.467.937', 'D23.529.937'], ['B01.050.150.900.649.313.50... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The relationship between hypotonically-induced taurine and K fluxes in trout red blood cells. | Hypotonic swelling of teleost erythrocytes activates multiple transport systems leading to the regulatory decrease of cell volume. We have examined using pharmacological manipulation the swelling-induced taurine flux pathway in red blood cells of the rainbow trout and its relationship to swelling-induced K flux pathway... | ['Animals', 'Biological Transport', 'Cell Size', 'Chlorides', 'Enzyme Inhibitors', 'Erythrocytes', 'Ethylmaleimide', 'Hypotonic Solutions', 'Marine Toxins', 'Oncorhynchus mykiss', 'Osmolar Concentration', 'Oxazoles', 'Potassium', 'Sodium', 'Staurosporine', 'Taurine'] | 10,954,334 | [['B01.050'], ['G03.143'], ['G04.325'], ['D01.210.450.150', 'D01.248.497.158.215'], ['D27.505.519.389'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['D02.241.081.337.502.524.418', 'D02.478.440.418', 'D03.383.129.578.399.418'], ['D26.776.399'], ['D23.946.580'], ['B01.050.150.900.493.817.750.825.580.600'], ['G02.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Cutaneous side-effects of treatment with lithium (author's transl)]. | This paper describes the cutaneous side-effects which appeared in 5 patients under Lithium medication for manic-depressive disease: 2 cases with facial and dorsal acne, 1 case with generalized pruritus with burning sensations on the tongue and tumefaction of the lips, 1 case with endogenous generalized psoriasis and 1 ... | ['Acne Vulgaris', 'Adult', 'Aged', 'Animals', 'Bipolar Disorder', 'Drug Eruptions', 'Female', 'Guinea Pigs', 'Humans', 'Ichthyosis', 'Keratoderma, Palmoplantar', 'Lithium', 'Male', 'Middle Aged', 'Pruritus', 'Psoriasis', 'Thyroid Diseases'] | 142,668 | [['C17.800.030.150', 'C17.800.794.111'], ['M01.060.116'], ['M01.060.116.100'], ['B01.050'], ['F03.084.500'], ['C17.800.174.600', 'C20.543.206.380', 'C25.100.468.380'], ['B01.050.150.900.649.313.992.550'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C16.131.831.512', 'C16.614.492', 'C17.800.428.333', 'C17.800.804... | ['Diseases [C]', 'Named Groups [M]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Peritonitis during the first year after commencement of peritoneal dialysis has an impact on technique survival and patient morbidity. | The timing of the first episode of peritonitis in peritoneal dialysis (PD) might have some special characteristics and may depend on many factors such as a patient's attitudes, age, comorbidity, or training capacity. It may also have a significant impact on further peritonitis episodes and technique failure. We retrosp... | ['Adolescent', 'Adult', 'Aged', 'Humans', 'Middle Aged', 'Peritoneal Dialysis', 'Peritonitis', 'Survival Analysis', 'Time Factors'] | 16,983,939 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E02.870.300.650', 'E02.912.800.650'], ['C01.463.600', 'C06.844.640'], ['E05.318.740.998', 'N05.715.360.750.795', 'N06.850.520.830.998'], ['G01.910.857']] | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A symplectic integration method for elastic filaments. | A new method is proposed for integrating the equations of motion of an elastic filament. In the standard finite-difference and finite-element formulations the continuum equations of motion are discretized in space and time, but it is then difficult to ensure that the Hamiltonian structure of the exact equations is pres... | ['Algorithms', 'Elasticity', 'Kinetics', 'Models, Molecular', 'Movement'] | 19,334,891 | [['G17.035', 'L01.224.050'], ['G01.374.590'], ['G01.374.661', 'G02.111.490'], ['E05.599.595'], ['G07.568', 'G11.427.410']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Colonization by fragments of the submerged macrophyte Myriophyllum spicatum under different sediment type and density conditions. | In this paper, the effect of plant density, sediment type, and macrophyte fragment size on the fragment colonization ability of Myriophyllum spicatum was evaluated in an outdoor experiment. The relative growth rate (RGR) was higher in the mud and low-density treatments than in the sand and high-density treatments. The ... | ['Aquatic Organisms', 'Introduced Species', 'Magnoliopsida', 'Plant Shoots', 'Reproduction', 'Rhizome', 'Seeds'] | 26,134,529 | [['B05.080', 'G16.500.275.725.500.650.075'], ['B01.050.050.580', 'G16.500.275.157.049.400', 'N06.230.124.049.400'], ['B01.650.940.800.575.912.250'], ['A18.024.875'], ['G08.686.784'], ['A18.024.937.750', 'A18.400.750'], ['A18.024.500.750', 'G07.203.300.775', 'J02.500.775']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
The nasopalatine duct cyst: an analysis of the relation between clinical symptoms, cyst dimensions, and involvement of neighboring anatomical structures using cone beam computed tomography. | PURPOSE: This study evaluates the dimensions of nasopalatine duct cysts (NPDCs) and the involvement of neighboring anatomical structures using standardized limited cone beam computed tomography (CBCT) and a possible correlation to the patient's age, gender, preoperative symptoms, and postsurgical complications.MATERIAL... | ['Adolescent', 'Age Factors', 'Aged', 'Child', 'Child, Preschool', 'Cone-Beam Computed Tomography', 'Female', 'Humans', 'Male', 'Maxillary Diseases', 'Middle Aged', 'Nonodontogenic Cysts', 'Nose Diseases', 'Palate, Hard', 'Postoperative Complications', 'Retrospective Studies', 'Risk Factors', 'Sex Factors', 'Statistics... | 21,398,010 | [['M01.060.057'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['M01.060.406'], ['M01.060.406.448'], ['E01.370.350.700.810.810.490', 'E01.370.350.825.810.810.399'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C05.500.693', 'C07.320.660'], ['M01.060.116.630'], ['C04.182.089.530.660', 'C05.500.470.... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Simple and novel method for measuring conduction velocity of A delta fibers in humans. | We report a simple new method for measuring the conduction velocity (CV) of A delta fibers in normal subjects. A large positive component of somatosensory evoked potential (SEP) whose peak latency was approximately 250 ms was clearly recorded only when strong electrical stimulation causing a definite painful feeling wa... | ['Adult', 'Electric Stimulation', 'Evoked Potentials, Somatosensory', 'Female', 'Humans', 'Leg', 'Male', 'Nerve Fibers', 'Neural Conduction', 'Neurophysiology', 'Pain', 'Peripheral Nerves', 'Reaction Time', 'Sleep', 'Time Factors'] | 9,563,582 | [['M01.060.116'], ['E05.723.402'], ['G07.265.216.500.400', 'G11.561.200.500.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A01.378.610.500'], ['A08.675.542', 'A11.671.501'], ['G07.265.753', 'G11.561.601'], ['H01.158.610.268', 'H01.158.782.562'], ['C23.888.592.612', 'F02.830.816.444', 'G11.561.790.444'], ['A0... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Disciplines and Occupations [H]', 'Diseases [C]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Risk of attempted suicide among adolescents and young adults with traumatic brain injury: A nationwide longitudinal study. | BACKGROUND: Traumatic brain injury (TBI) and suicidal behavior lead to serious morbidity and premature mortality. TBI in adulthood is associated with a higher incidence of suicide, but the risk in adolescents and young adults is not clear.METHODS: Longitudinal follow-up data were extracted from a National Health Insura... | ['Adolescent', 'Adult', 'Age Factors', 'Bipolar Disorder', 'Brain Injuries, Traumatic', 'Child', 'Cohort Studies', 'Comorbidity', 'Depressive Disorder', 'Female', 'Humans', 'Incidence', 'Longitudinal Studies', 'Male', 'Risk Factors', 'Sex Factors', 'Substance-Related Disorders', 'Suicide, Attempted', 'Young Adult'] | 30,826,490 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['F03.084.500'], ['C10.228.140.199.444', 'C10.900.300.087.235', 'C26.915.300.200.194'], ['M01.060.406'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['N05.715.350.225', 'N06.850.490.687'], ['F03.600.300'], ['B0... | ['Named Groups [M]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Profiling the RNA editomes of wild-type C. elegans and ADAR mutants. | RNA editing increases transcriptome diversity through post-transcriptional modifications of RNA. Adenosine deaminases that act on RNA (ADARs) catalyze the adenosine-to-inosine (A-to-I) conversion, the most common type of RNA editing in higher eukaryotes. Caenorhabditis elegans has two ADARs, ADR-1 and ADR-2, but their ... | ['Adenosine', 'Adenosine Deaminase', 'Animals', 'Base Sequence', 'Caenorhabditis elegans', 'Caenorhabditis elegans Proteins', 'Chromosome Mapping', 'Computational Biology', 'DNA Transposable Elements', 'Evaluation Studies as Topic', 'Gene Deletion', 'Genetic Association Studies', 'Molecular Sequence Data', 'Multigene F... | 25,373,143 | [['D03.633.100.759.590.138', 'D13.570.583.138', 'D13.570.800.096'], ['D08.811.277.151.486.075'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['B01.050.500.500.294.400.875.660.250.250'], ['D12.776.419.500'], ['E05.393.183'], ['H01.158.273.180', 'L01.313.124'], ['D13.444.308.520', 'G02.111.570... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
[Adenomatous tissue in colorectal carcinomas: clinical significance and probable histogenetic implications of morphological differences]. | In this study we tested the hypothesis that colorectal cancers containing adenoma (CCA) could be a different entity from colon cancers without adenoma (CSA). Clinical data, histologic preparations of operative specimens and survival of 210 patients who underwent resective surgery for colorectal cancer were studied. Ade... | ['Adenoma', 'Adenoma, Villous', 'Age Factors', 'Colorectal Neoplasms', 'Female', 'Humans', 'Male', 'Middle Aged', 'Time Factors'] | 9,148,207 | [['C04.557.470.035'], ['C04.557.470.035.185'], ['N05.715.350.075', 'N06.850.490.250'], ['C04.588.274.476.411.307', 'C06.301.371.411.307', 'C06.405.249.411.307', 'C06.405.469.158.356', 'C06.405.469.491.307', 'C06.405.469.860.180'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['G01.910.857']] | ['Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Root angle modifications by the DRO1 | The root system architecture (RSA) of crops can affect their production, particularly in abiotic stress conditions, such as with drought, waterlogging, and salinity. Salinity is a growing problem worldwide that negatively impacts on crop productivity, and it is believed that yields could be improved if RSAs that enable... | ['Alleles', 'Arabidopsis Proteins', 'Droughts', 'Indoleacetic Acids', 'Nuclear Proteins', 'Oryza', 'Phenotype', 'Plant Roots', 'Quantitative Trait Loci'] | 32,817,523 | [['G05.360.340.024.340.030'], ['D12.776.765.149'], ['G16.500.175.781', 'G16.500.750.775.154', 'N06.230.100.230.150'], ['D03.066.288', 'D03.633.100.473.404'], ['D12.776.660'], ['B01.650.940.800.575.912.250.822.616'], ['G05.695'], ['A18.400'], ['G05.360.340.024.380.937']] | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Serine protease inhibitor kunitz-type 2 is downregulated in myelodysplastic syndromes and modulates cell-cell adhesion. | Myelodysplastic syndromes (MDS) are clonal disorders involving hematopoietic stem cells (HSC) characterized by ineffective hematopoiesis. In addition to HSC defects, a defective hematopoiesis supporting capacity of mesenchymal stromal cells (MSCs) in the microenvironment niche has been implicated in MDS pathophysiology... | ['Adolescent', 'Adult', 'Cell Adhesion', 'Cell Proliferation', 'Cell Survival', 'Cells, Cultured', 'Chemokine CXCL12', 'Down-Regulation', 'Female', 'Gene Knockdown Techniques', 'Hematopoietic Stem Cells', 'Hepatocyte Growth Factor', 'Humans', 'Integrin alpha5', 'Male', 'Membrane Glycoproteins', 'Mesenchymal Stem Cells'... | 24,410,667 | [['M01.060.057'], ['M01.060.116'], ['G04.022'], ['G04.161.750', 'G07.345.249.410.750'], ['G04.346'], ['A11.251'], ['D12.644.276.374.200.120.600', 'D12.776.467.374.200.120.600', 'D23.125.300.120.600', 'D23.469.200.120.600', 'D23.529.374.200.120.600'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['E05.393.335.500'... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A complex interaction of imprinted and maternal-effect genes modifies sex determination in Odd Sex (Ods) mice. | The transgenic insertional mouse mutation Odd Sex (Ods) represents a model for the long-range regulation of Sox9. The mutation causes complete female-to-male sex reversal by inducing a male-specific expression pattern of Sox9 in XX Ods/+ embryonic gonads. We previously described an A/J strain-specific suppressor of Ods... | ['Animals', 'Crosses, Genetic', 'Female', 'Genomic Imprinting', 'Inbreeding', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Pedigree', 'Sex Determination Processes'] | 15,579,706 | [['B01.050'], ['E05.393.281'], ['G05.308.203.500'], ['E05.820.150.520', 'G05.090.403'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420'], ['E05.393.673'], ['G05.813', 'G07.345.500.325.377.812', 'G07.345.750.437', 'G08.686.841.437']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Phenol concentrations in the air from disinfection solutions. | Phenol concentrations in the air near phenol disinfectant solutions were measured. The concentration of phenol was not excessive, except for hot solutions with which exposure would normally be for a very short time. Adverse physiological reactions may occur at air levels below the threshold limit values which may be es... | ['Air Pollution', 'Antipyrine', 'Disinfectants', 'Environmental Exposure', 'Indicators and Reagents', 'Occupational Diseases', 'Phenols', 'Pyrazoles', 'Sterilization', 'Temperature'] | 5,137,587 | [['N06.850.460.100'], ['D03.383.129.539.850.088'], ['D27.505.954.122.425', 'D27.720.274'], ['N06.850.460.350'], ['D27.720.470.410'], ['C24'], ['D02.455.426.559.389.657'], ['D03.383.129.539'], ['N06.850.780.200.450.850'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.150.450', 'N06.230.300.1... | ['Health Care [N]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
A microPET comparison of the effects of etifoxine and diazepam on [(11)C]flumazenil uptake in rat brains. | Using positron emission tomography (PET), the present study assessed the binding of [(11)C]flumazenil to GABA-A receptors in anesthetized rats following a single intravenous injection of an active dose of either etifoxine (25mg/kg) or diazepam (1mg/kg), which are both anxiolytic drugs. [(11)C]flumazenil binding was mea... | ['Animals', 'Anti-Anxiety Agents', 'Brain', 'Carbon Isotopes', 'Diazepam', 'Flumazenil', 'Magnetic Resonance Imaging', 'Male', 'Oxazines', 'Positron-Emission Tomography', 'Protein Binding', 'Radiopharmaceuticals', 'Rats, Wistar', 'Receptors, GABA-A'] | 26,644,334 | [['B01.050'], ['D27.505.696.277.950.015', 'D27.505.954.427.210.950.015', 'D27.505.954.427.700.872.015'], ['A08.186.211'], ['D01.268.150.075', 'D01.496.123'], ['D03.633.100.079.080.070.216'], ['D03.633.100.079.080.070.305'], ['E01.370.350.825.500'], ['D03.383.533'], ['E01.370.350.350.800.700', 'E01.370.350.600.350.800.3... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The role of age in treatment-related adverse events in patients with head and neck cancer: A systematic review. | Head and neck squamous cell carcinoma (HNSCC) is often diagnosed in advanced stage and therefore requires aggressive, multimodal treatment. Elderly patients are often excluded from standard therapy regimens purely based on age. This clinical review aims to collect all published data in the literature on treatment modal... | ['Age Factors', 'Aged', 'Carcinoma, Squamous Cell', 'Combined Modality Therapy', 'Comorbidity', 'Enhanced Recovery After Surgery', 'Frailty', 'Geriatric Assessment', 'Head and Neck Neoplasms', 'Humans', 'Neoplasm Metastasis', 'Neoplasm Recurrence, Local', 'Operative Time', 'Patient Selection', 'Postoperative Complicati... | 30,737,976 | [['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['E02.186'], ['N05.715.350.225', 'N06.850.490.687'], ['E04.604.125'], ['C23.550.359'], ['E05.318.308.225', 'I01.240.425.350', 'N01.224.425.350', 'N05.715.360.300.360', 'N06.850.505.400.425.350', 'N06.850.520.30... | ['Health Care [N]', 'Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
The Wnt1 ligand/Frizzled 3 receptor system plays a regulatory role in the achievement of the 'in vitro' capacitation and subsequent 'in vitro' acrosome exocytosis of porcine spermatozoa. | The aim of this work was to determine the existence of a functional Wnt/â-catenin signaling pathway in boar spermatozoa, which would be linked with the already well-known GSK-3 signaling pathway. This was first confirmed by detecting the presence of the specific Frizzled 3 receptor in these cells. Furthermore, this sig... | ['Animals', 'Exocytosis', 'Frizzled Receptors', 'In Vitro Techniques', 'Male', 'Sperm Capacitation', 'Swine', 'Wnt1 Protein'] | 25,656,424 | [['B01.050'], ['G04.468'], ['D12.776.543.750.695.017', 'D12.776.543.750.850.500'], ['E05.481'], ['G08.686.784.277.760'], ['B01.050.150.900.649.313.500.880'], ['D12.776.467.984.100', 'D12.776.624.664.700.967', 'D23.529.984.100']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Efficacy of the application of a coating composed of chitosan and Origanum vulgare L. essential oil to control Rhizopus stolonifer and Aspergillus niger in grapes (Vitis labrusca L.). | This study evaluated the efficacy of the combined application of chitosan (CHI) and Origanum vulgare L. essential oil (OV) in the inhibition of Rhizopus stolonifer URM 3728 and Aspergillus niger URM 5842 on laboratory media and on grapes (Vitis labrusca L.) and its influence on the physical, physicochemical and sensory... | ['Aspergillus niger', 'Chitosan', 'Food Preservation', 'Food Storage', 'Fruit', 'Microbial Sensitivity Tests', 'Mycelium', 'Oils, Volatile', 'Origanum', 'Plant Extracts', 'Rhizopus', 'Spores, Fungal', 'Vitis'] | 22,986,200 | [['B01.300.381.081.450'], ['D05.750.078.139.500', 'D09.698.211.500'], ['J01.576.423.850.700'], ['J01.576.423.200.387'], ['A18.024.500', 'G07.203.300.562', 'J02.500.562'], ['E01.370.225.875.595', 'E05.200.875.595', 'E05.337.550.400'], ['A19.687'], ['D10.627.675'], ['B01.650.940.800.575.912.250.583.520.702'], ['D20.215.7... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
[Suicide attempts in Brittany (France). Distribution at the regional level]. | UNLABELLED: A prospective study on para-suicide has been conducted in all 4 "d?partements" of a french region, Brittany. This paper analyses the distribution of the sociodemographic data collected in one of the "d?partement" of the region, Ille-et-Vilaine. The comparison between urban and rural areas is presented.INCLU... | ['Adolescent', 'Adult', 'Aged', 'Catchment Area, Health', 'Child', 'Female', 'France', 'Humans', 'Incidence', 'Male', 'Marital Status', 'Middle Aged', 'Occupations', 'Prevalence', 'Prospective Studies', 'Rural Population', 'Sex Distribution', 'Suicide, Attempted', 'Urban Population'] | 12,404,781 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['N01.224.791.200', 'N03.349.650.095', 'N06.850.505.400.800.200'], ['M01.060.406'], ['Z01.542.286'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.985.525.375'], ... | ['Named Groups [M]', 'Health Care [N]', 'Geographicals [Z]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Depopulation of dense á-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson's disease model. | Parkinson's disease (PD) is characterized by the presence of á-synuclein aggregates known as Lewy bodies and Lewy neurites, whose formation is linked to disease development. The causal relation between á-synuclein aggregates and PD is not well understood. We generated a new transgenic mouse line (MI2) expressing human,... | ['Animals', 'Cell Death', 'Disease Models, Animal', 'Dopaminergic Neurons', 'Gait', 'Mice', 'Mice, Transgenic', 'Motor Activity', 'Parkinson Disease', 'Protein Aggregation, Pathological', 'Substantia Nigra', 'Tyrosine 3-Monooxygenase', 'alpha-Synuclein'] | 31,165,254 | [['B01.050'], ['G04.146'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['A08.675.278', 'A11.671.270'], ['E01.370.600.250', 'G11.427.410.568.900.750'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.136.500', 'B01.050.150.900.649.313.992.635.505.500.800'], ['F01.145.632', 'G11.427.410.698'], ['C10.228.140... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
LcrF is the temperature-regulated activator of the yadA gene of Yersinia enterocolitica and Yersinia pseudotuberculosis. | The virulence plasmid of human pathogenic Yersinia species, pYV, encodes secreted proteins, Yop proteins, and an outer membrane protein, YadA. YadA has been associated with binding to a variety of substrates and with interference with host defense. YadA is regulated by temperature and is expressed only at 37 degrees C.... | ['Bacterial Outer Membrane Proteins', 'Base Sequence', 'Cloning, Molecular', 'Gene Expression Regulation, Bacterial', 'Genes, Bacterial', 'Molecular Sequence Data', 'Oligodeoxyribonucleotides', 'Plasmids', 'Polymerase Chain Reaction', 'Temperature', 'Yersinia enterocolitica', 'Yersinia pseudotuberculosis'] | 1,548,243 | [['D12.776.097.120', 'D12.776.543.100'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.393.220'], ['G05.308.300'], ['G05.360.340.024.340.364.249', 'G05.360.340.358.024.249', 'G05.360.340.358.207.249'], ['L01.453.245.667'], ['D13.695.578.424.450'], ['G05.360.600'], ['E05.393.620.500'], ['G01.906.595',... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Noncompliance and drug toxicity in black, poor, and aged patients. | Drug toxicity is a common medical problem. Continued increases in drug toxicity are related to the extensive, indiscriminate use of drugs. This is a national health problem which is caused partly by gaps in pharmacology as a basic and clinical science and partly by the rapid proliferation of drugs (the drug explosion) ... | ['African Americans', 'Aged', 'Humans', 'Patient Compliance', 'Poverty', 'Socioeconomic Factors', 'Toxicology', 'United States'] | 712,862 | [['M01.686.508.100.100', 'M01.686.754.100'], ['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.100.150.750.500.600', 'F01.145.488.887.500.600', 'N05.300.150.800.500.600'], ['I01.880.735.634', 'I01.880.853.996.535', 'N01.824.600'], ['I01.880.853.996', 'N01.824'], ['H01.158.891', 'H02.884'], ['Z... | ['Named Groups [M]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Disciplines and Occupations [H]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Preclinical safety evaluation of cerivastatin, a novel HMG-CoA reductase inhibitor. | Cerivastatin is a new but structurally distinct 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor ("statin"). It effectively decreases low-density lipoprotein (LDL) cholesterol at 1% of the doses of other currently available statins. The toxicology of cerivastatin was evaluated in a comprehensive prog... | ['Administration, Oral', 'Animals', 'Central Nervous System', 'Digestive System', 'Dogs', 'Dose-Response Relationship, Drug', 'Drug Evaluation, Preclinical', 'Eye', 'Female', 'Gonads', 'Haplorhini', 'Hydroxymethylglutaryl-CoA Reductase Inhibitors', 'Kidney', 'Liver', 'Male', 'Mice', 'Muscle, Skeletal', 'Pyridines', 'Ra... | 9,737,641 | [['E02.319.267.100'], ['B01.050'], ['A08.186'], ['A03'], ['B01.050.150.900.649.313.750.250.216.200'], ['G07.690.773.875', 'G07.690.936.500'], ['E05.290.750', 'E05.337.550'], ['A01.456.505.420', 'A09.371'], ['A05.360.576', 'A06.300.312'], ['B01.050.150.900.649.313.988.400'], ['D27.505.519.186.071.202.370', 'D27.505.519.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Flight mechanics and control of escape manoeuvres in hummingbirds. II. Aerodynamic force production, flight control and performance limitations. | The superior manoeuvrability of hummingbirds emerges from complex interactions of specialized neural and physiological processes with the unique flight dynamics of flapping wings. Escape manoeuvring is an ecologically relevant, natural behaviour of hummingbirds, from which we can gain understanding into the functional ... | ['Acceleration', 'Animals', 'Biomechanical Phenomena', 'Birds', 'Escape Reaction', 'Flight, Animal', 'Models, Biological', 'Muscles', 'Organ Size', 'Rotation', 'Time Factors', 'Uncertainty'] | 27,595,849 | [['G01.482.107'], ['B01.050'], ['G01.154.090', 'G01.374.089'], ['B01.050.150.900.248'], ['F01.145.113.780.688', 'F01.145.367', 'F01.145.875.439.500.688', 'G07.568.500.590.688', 'G11.427.410.568.850.688'], ['G11.427.410.568.304', 'G11.427.410.698.416'], ['E05.599.395'], ['A02.633', 'A10.690'], ['E01.370.600.115.100.660'... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Survival from spinal cord injury. | Mean survival of 110.5 months (9 yr. 2.5 months) for spinal cord-injured persons who died between 1963 to 1976 compared favorable with the figure of 52.8 months (4 yr, 4.8 months) calculated in 1955 by Dietrick and Russi [1]. If suicides were not considered, then mean longevity for the deceased patients would be 126 mo... | ['Adolescent', 'Adult', 'Aged', 'Cardiovascular Diseases', 'Female', 'Humans', 'Life Expectancy', 'Male', 'Middle Aged', 'Paraplegia', 'Quadriplegia', 'Respiratory Tract Diseases', 'Spinal Cord Injuries', 'Suicide', 'Urologic Diseases'] | 7,076,789 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['C14'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.450', 'N01.224.935.464', 'N06.850.505.400.975.450', 'N06.850.520.308.985.450'], ['M01.060.116.630'], ['C10.597.622.669', 'C23.888.592.636.637'], ['C10.597.622.760', 'C23.888.592.636.786'],... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
[Electrophysiological properties of the cells in intermediolateral nucleus of neonatal rat spinal cord slices in vitro]. | Intracellular recordings were made from the cells in the interm ediolateral nucleus (IML) of neonatal rat spinal cord slices in vitro. Both resting and active electrophysiological properties of the cellular membrane were investigated. Resting membrane potential ranged from -46 to -70 mV. The means of input resistance, ... | ['Animals', 'Animals, Newborn', 'Autonomic Fibers, Preganglionic', 'Electrophysiology', 'Ganglia, Sympathetic', 'In Vitro Techniques', 'Neurons', 'Rats', 'Spinal Cord'] | 2,762,832 | [['B01.050'], ['B01.050.050.282'], ['A08.675.127.500.060', 'A08.675.542.234.060', 'A08.800.050.050.060', 'A08.800.800.060.060', 'A11.671.188.500.060', 'A11.671.501.234.060'], ['H01.158.344.528', 'H01.158.782.236'], ['A08.340.315.350', 'A08.800.050.300.300', 'A08.800.050.800.300'], ['E05.481'], ['A08.675', 'A11.671'], [... | ['Organisms [B]', 'Anatomy [A]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Prevalence of Dirofilaria immitis infection in dogs from a humane shelter in Ohio. | Hearts of 500 dogs more than 1 year old from a humane shelter in Columbus, Oh, were examined for Dirofilaria immitis infection. Peripheral blood from dogs with worms in the heart was examined for microfilariae. Dirofilaria immitis adults were found in 24 (4.8%) hearts. The number of worms in infected hearts were: 19 (1... | ['Animals', 'Dirofilaria immitis', 'Dirofilariasis', 'Dog Diseases', 'Dogs', 'Female', 'Male', 'Ohio'] | 870,466 | [['B01.050'], ['B01.050.500.500.294.400.937.463.230.300'], ['C01.610.335.349.320', 'C01.610.335.508.700.750.361.290', 'C01.610.701.377.320', 'C22.674.377.320'], ['C22.268'], ['B01.050.150.900.649.313.750.250.216.200'], ['Z01.107.567.875.075.512', 'Z01.107.567.875.350.540', 'Z01.107.567.875.510.540']] | ['Organisms [B]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Multi-parametric MRI Diagnoses Cerebellar Hemangioblastoma: A Case Report. | We performed contrast-enhanced T2 fluid-attenuated inversion recovery (T2-FLAIR) and dynamic contrast enhanced MRI to illustrate the imaging characteristics of one case of hemangioblastoma. T2-FLAIR showed a large cyst located in the right cerebellum with mural nodule. The intensely enhancing cyst wall was observed on ... | ['Cerebellar Neoplasms', 'Contrast Media', 'Female', 'Hemangioblastoma', 'Humans', 'Magnetic Resonance Imaging', 'Middle Aged', 'Tomography, X-Ray Computed'] | 30,266,110 | [['C04.588.614.250.195.411.211', 'C10.228.140.211.500.200', 'C10.228.140.252.200', 'C10.551.240.250.400.300'], ['D27.505.259.500', 'D27.720.259'], ['C04.557.645.375.380.370'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['M01.060.116.630'], ['E01.370.350.350.810', 'E01.370.350.600.350.700.... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Increasing risk behaviour and high levels of undiagnosed HIV infection in a community sample of homosexual men. | OBJECTIVES: To estimate changes in sexual behaviour over time. To examine the proportion of undiagnosed HIV infection in a community sample of homosexual men. To explore the relation between HIV status, diagnosis, and sexual behaviour.METHODS: Five cross sectional surveys of men attending selected gay community venues ... | ['Adult', 'Aged', 'Cross-Sectional Studies', 'HIV Infections', 'Homosexuality, Male', 'Humans', 'Male', 'Middle Aged', 'Risk-Taking', 'Safe Sex', 'Saliva', 'Sexual Partners'] | 15,170,012 | [['M01.060.116'], ['M01.060.116.100'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['F01.145.802.975.500.600', 'G08.686.867.500.600'], ['B01.050.150.900.649.313.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Kit preparation of technetium-99m-mercaptoacetyltriglycine: analysis, biodistribution and comparison with technetium-99m-DTPA in patients with impaired renal function. | Technetium-99m-mercaptoacetyltriglycine (99mTc-MAG3) was prepared by a frozen solution method, enabling the preparation of kits yielding a product substantially free of lipophilic impurities (96% 99mTc-MAG3). However, biliary activity was not completely eliminated as HPLC-purified 99mTc-MAG3 was also excreted by that r... | ['Chromatography, High Pressure Liquid', 'Humans', 'Kidney', 'Kidney Diseases', 'Oligopeptides', 'Organotechnetium Compounds', 'Pentetic Acid', 'Radionuclide Imaging', 'Reagent Kits, Diagnostic', 'Technetium Tc 99m Mertiatide', 'Technetium Tc 99m Pentetate', 'Tissue Distribution'] | 2,144,317 | [['E05.196.181.400.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A05.810.453'], ['C12.777.419', 'C13.351.968.419'], ['D12.644.456'], ['D02.691.825'], ['D02.092.782.590', 'D02.241.081.018.639'], ['E01.370.350.710', 'E01.370.384.730'], ['D27.505.259.875', 'D27.720.470.410.680', 'E07.720'], ['D02.691.825.775',... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Drift in Neural Population Activity Causes Working Memory to Deteriorate Over Time. | Short-term memories are thought to be maintained in the form of sustained spiking activity in neural populations. Decreases in recall precision observed with increasing number of memorized items can be accounted for by a limit on total spiking activity, resulting in fewer spikes contributing to the representation of ea... | ['Adolescent', 'Adult', 'Algorithms', 'Computer Simulation', 'Cues', 'Electrophysiological Phenomena', 'Eye Movements', 'Female', 'Humans', 'Male', 'Memory Disorders', 'Memory, Short-Term', 'Mental Recall', 'Middle Aged', 'Neurons', 'Psychomotor Performance', 'Saccades', 'Young Adult'] | 29,703,786 | [['M01.060.057'], ['M01.060.116'], ['G17.035', 'L01.224.050'], ['L01.224.160'], ['F02.463.425.234'], ['G07.265'], ['G11.427.410.140', 'G14.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.597.606.525', 'C23.888.592.604.529', 'F01.700.625'], ['F02.463.425.540.407'], ['F02.463.425.540.641'], ['M01.060.116.63... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Bacterial sugar utilization gives rise to distinct single-cell behaviours. | Inducible utilization pathways reflect widespread microbial strategies to uptake and consume sugars from the environment. Despite their broad importance and extensive characterization, little is known how these pathways naturally respond to their inducing sugar in individual cells. Here, we performed single-cell analys... | ['Carbohydrate Metabolism', 'Escherichia coli', 'Gene Expression Regulation, Bacterial', 'Metabolic Networks and Pathways', 'Models, Biological', 'Single-Cell Analysis'] | 24,976,172 | [['G02.111.158', 'G03.191'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['G05.308.300'], ['G03.493'], ['E05.599.395'], ['E05.242.900']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The pharmacokinetics of cotrimoxazole sulphonamide in malnourished (marasmic) infants. | The pharmacokinetics of trimethoprim-sulphamethoxazole was examined in seven malnourished (marasmic) infants receiving cotrimoxazole (CMZ) for treatment of urinary tract infection. Comparisons were made with the SMZ level of ten nutritionally normal infants, hospitalized for first and second degree burns, receiving CMZ... | ['Drug Combinations', 'Female', 'Humans', 'Infant', 'Kinetics', 'Male', 'Protein-Energy Malnutrition', 'Sulfamethoxazole', 'Trimethoprim', 'Trimethoprim, Sulfamethoxazole Drug Combination'] | 6,436,778 | [['D26.310'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['G01.374.661', 'G02.111.490'], ['C18.654.521.500.708.626'], ['D02.065.884.725.867', 'D02.092.146.807.867', 'D02.886.590.700.725.867'], ['D03.383.742.906'], ['D02.065.884.725.867.500', 'D02.092.146.807.867.500', 'D02.886.590.700.725.867.500... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Variable phenotype in a P102L Gerstmann-Str?ussler-Scheinker Italian family. | BACKGROUND: Gerstmann-Str?ussler-Scheinker disease is an autosomal dominant prion disease. The clinical features include ataxia, dementia, spastic paraparesis and extrapyramidal signs.METHODS: We report a new large Italian family affected by Gerstmann-Str?ussler-Scheinker disease.RESULTS: The four generation pedigree i... | ['Adult', 'Aged', 'Amyloid', 'Ataxia', 'Cerebellum', 'Cognition Disorders', 'Female', 'Gerstmann-Straussler-Scheinker Disease', 'Humans', 'Italy', 'Magnetic Resonance Imaging', 'Male', 'Mutation', 'Pedigree', 'Phenotype', 'Prion Proteins', 'Prions', 'Protein Precursors'] | 12,945,948 | [['M01.060.116'], ['M01.060.116.100'], ['D05.500.049', 'D12.776.049'], ['C10.597.350.090', 'C23.888.592.350.090'], ['A08.186.211.132.810.428.200'], ['F03.615.250'], ['C01.207.800.350', 'C10.228.228.800.350', 'C10.574.500.425', 'C10.574.843.400', 'C16.320.400.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
Prevalence of anti-nuclear autoantibodies in subjects exposed to natural asbestiform fibers: a cross-sectional study. | Fluoro-edenite (FE) is an asbestiform mineral fiber spotted in the lava rocks excavated from a stone quarry in Biancavilla (Italy). The derived material had been employed locally for building purposes. Previous studies found evidence that exposure to asbestos may induce autoimmunity, with frequency of anti-nuclear auto... | ['Adult', 'Antibodies, Antinuclear', 'Asbestos, Amphibole', 'Autoimmune Diseases', 'Construction Materials', 'Cross-Sectional Studies', 'Environmental Exposure', 'Female', 'Humans', 'Italy', 'Lung', 'Male', 'Middle Aged', 'Mineral Fibers', 'Pleural Diseases', 'Prevalence', 'Spirometry'] | 29,241,379 | [['M01.060.116'], ['D12.776.124.486.485.114.323.204', 'D12.776.124.790.651.114.323.204', 'D12.776.377.715.548.114.323.204'], ['D01.578.725.050.050', 'D01.837.725.700.760.070.050'], ['C20.111'], ['J01.637.241'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['N06.850.460.350'], ['B01.050... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
Evidence for the existence of a family of biologically active angiotensin I-like peptides in the dog central nervous system. | A family of angiotensin I-like peptides has been derived from endogenous precursors present in dog cerebrospinal fluid after incubation with species homologous renin. These peptides are immunologically and pharmacologically similar to [Ile5]angiotensin I, and have molecular weights ranging between 1300 and 2200 daltons... | ['Angiotensin I', 'Angiotensins', 'Animals', 'Brain', 'Central Nervous System', 'Cerebrospinal Fluid', 'Chromatography, High Pressure Liquid', 'Chromatography, Ion Exchange', 'Dogs', 'Molecular Weight', 'Peptides', 'Renin'] | 6,339,108 | [['D06.472.699.094.075', 'D12.644.400.070.075', 'D12.644.456.073.021', 'D12.644.548.058.075', 'D12.776.631.650.070.075', 'D23.469.050.050.025'], ['D06.472.699.094', 'D12.644.400.070', 'D12.644.456.073', 'D12.644.548.058', 'D12.776.631.650.070', 'D23.469.050.050'], ['B01.050'], ['A08.186.211'], ['A08.186'], ['A12.207.27... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Regulation of G protein-coupled receptor-adenylyl cyclase responsiveness in human airway smooth muscle by exogenous and autocrine adenosine. | Adenosine is a mediator of bronchoconstriction in asthmatics and is believed to mediate its effects through adenosine receptor activation in inflammatory cells. In this study, we identify human airway smooth muscle (ASM) as a direct target of adenosine. Acute exposure of human ASM cultures to adenosine receptor (AR) ag... | ['Adenosine', "Adenosine-5'-(N-ethylcarboxamide)", 'Adenylyl Cyclases', 'Cells, Cultured', 'Cyclic AMP', 'DNA Primers', 'Fluorescence', 'GTP-Binding Protein Regulators', 'Gene Expression Regulation, Enzymologic', 'Green Fluorescent Proteins', 'Humans', 'Isoenzymes', 'Luminescent Proteins', 'Muscle, Smooth', 'Polymerase... | 11,159,049 | [['D03.633.100.759.590.138', 'D13.570.583.138', 'D13.570.800.096'], ['D03.633.100.759.590.138.025', 'D13.570.583.138.025', 'D13.570.800.096.250'], ['D08.811.520.650.200', 'D12.644.360.050', 'D12.776.476.050'], ['A11.251'], ['D03.633.100.759.646.138.395', 'D13.695.462.200', 'D13.695.667.138.395', 'D13.695.827.068.395'],... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Malaria parasite clag3 genes determine channel-mediated nutrient uptake by infected red blood cells. | Development of malaria parasites within vertebrate erythrocytes requires nutrient uptake at the host cell membrane. The plasmodial surface anion channel (PSAC) mediates this transport and is an antimalarial target, but its molecular basis is unknown. We report a parasite gene family responsible for PSAC activity. We us... | ['Amino Acid Sequence', 'Crosses, Genetic', 'Erythrocytes', 'High-Throughput Screening Assays', 'Humans', 'Ion Channels', 'Leupeptins', 'Molecular Sequence Data', 'Mutation', 'Permeability', 'Plasmodium falciparum', 'Protozoan Proteins', 'Sequence Alignment'] | 21,620,134 | [['G02.111.570.060', 'L01.453.245.667.060'], ['E05.393.281'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['E05.916.680'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.157.530.400', 'D12.776.543.550.450', 'D12.776.543.585.400'], ['D12.644.456.580'], ['L01.453.245.667'], ['G05.365.590'], ['G02.723']... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Beta-carotene uptake and changes in ovarian steroids and uterine proteins during the estrous cycle in the canine. | The uptake of beta-carotene by reproductive tissues and the effects of beta-carotene on reproductive function in the dog are unknown. We studied the uptake of beta-carotene by blood, corpus luteum, and uterine endometrium and the role of dietary beta-carotene in influencing ovarian steroid and uterine protein productio... | ['Animals', 'Chromatography, High Pressure Liquid', 'Corpus Luteum', 'Dogs', 'Endometrium', 'Estradiol', 'Estrus', 'Female', 'Ovary', 'Proteins', 'Radioimmunoassay', 'Steroids', 'Uterus', 'beta Carotene'] | 10,834,584 | [['B01.050'], ['E05.196.181.400.300'], ['A05.360.319.114.630.278', 'A06.300.312.497.278'], ['B01.050.150.900.649.313.750.250.216.200'], ['A05.360.319.679.490'], ['D04.210.500.365.415.248', 'D06.472.334.851.437.500'], ['G08.686.195.500'], ['A05.360.319.114.630', 'A05.360.576.497', 'A06.300.312.497'], ['D12.776'], ['E01.... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mild, short-term stress alters dendritic morphology in rat medial prefrontal cortex. | Prefrontal cortex is a target for glucocorticoids, shows neurochemical changes in response to stress and mediates many of the behaviors that are altered by chronic corticosterone administration. Three weeks of either daily corticosterone injections or 3 h daily restraint stress result in dendritic changes in pyramidal ... | ['Adaptation, Physiological', 'Animals', 'Corticosterone', 'Dendrites', 'Male', 'Neuronal Plasticity', 'Prefrontal Cortex', 'Rats', 'Rats, Sprague-Dawley', 'Restraint, Physical', 'Stress, Physiological'] | 15,703,248 | [['G07.025', 'G16.012.500'], ['B01.050'], ['D04.210.500.745.745.654.237', 'D06.472.040.585.353.237'], ['A08.675.256', 'A11.284.180.225', 'A11.671.240'], ['G11.561.638'], ['A08.186.211.200.885.287.500.270.700'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.750'], ['E02.085.700',... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Second-look arthroscopic findings of 208 patients after ACL reconstruction. | The aim of this study is to report the arthroscopic subjective findings of reconstructed anterior cruciate ligament (ACL) with good clinical outcome. Graft used for reconstruction was either patella bone-tendon-bone (PBTB) autograft or hamstring tendon [quadrupled semitendinous and gracilis tendon (QSGT)] autograft. Fr... | ['Adolescent', 'Adult', 'Anterior Cruciate Ligament', 'Anterior Cruciate Ligament Injuries', 'Arthrometry, Articular', 'Arthroscopy', 'Bone-Patellar Tendon-Bone Grafting', 'Female', 'Humans', 'Male', 'Middle Aged', 'Outcome Assessment, Health Care', 'Postoperative Complications', 'Second-Look Surgery', 'Tendons', 'Tran... | 17,028,869 | [['M01.060.057'], ['M01.060.116'], ['A02.513.514.100', 'A02.835.583.512.100', 'A10.165.669.514.100'], ['C26.558.554.213'], ['E01.370.600.700.500', 'G11.427.760.500'], ['E01.370.388.250.070', 'E04.502.250.070', 'E04.555.113'], ['E02.095.147.725.065', 'E04.555.110.026.500', 'E04.680.101.026.500', 'E04.936.580.065'], ['B0... | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Scavenging of cytosolic octanoic acid by mutant LplA lipoate ligases allows growth of Escherichia coli strains lacking the LipB octanoyltransferase of lipoic acid synthesis. | The LipB octanoyltransferase catalyzes the first step of lipoic acid synthesis in Escherichia coli, transfer of the octanoyl moiety from octanoyl-acyl carrier protein to the lipoyl domains of the E2 subunits of the 2-oxoacid dehydrogenases of aerobic metabolism. Strains containing null mutations in lipB are auxotrophic... | ['Acyltransferases', 'Blotting, Western', 'Caprylates', 'Cytosol', 'Escherichia coli', 'Escherichia coli Proteins', 'Kinetics', 'Ligases', 'Models, Biological', 'Mutagenesis', 'Mutation', 'Mutation, Missense', 'Polymerase Chain Reaction', 'Thioctic Acid'] | 19,684,135 | [['D08.811.913.050'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['D02.241.081.222', 'D10.251.122'], ['A11.284.430.214.200', 'A11.284.430.429.200', 'A11.284.835.450.200'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D12.776.097.275'], ['G01.374.661... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Experimental vertical transmission of West Nile virus by Culex pipiens (Diptera: Culicidae). | Despite the detection of West Nile (WN) virus in overwintering Culex pipiens L. in New York in February 2000, the mechanism by which this virus persists throughout the winter to initiate infections in vertebrate hosts and vectors the following spring remains unknown. After a blood meal, parous mosquitoes generally do n... | ['Aedes', 'Animals', 'Chlorocebus aethiops', 'Culex', 'Female', 'Male', 'Vero Cells', 'West Nile virus'] | 12,144,296 | [['B01.050.500.131.617.720.500.500.750.712.500.875.100'], ['B01.050'], ['B01.050.150.900.649.313.988.400.112.199.120.126.110'], ['B01.050.500.131.617.720.500.500.750.712.500.875.225'], ['A11.251.210.955', 'A11.436.955'], ['B04.820.230.475.950', 'B04.820.578.344.350.300.950']] | ['Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Phytoextraction of rare earth elements in herbaceous plant species growing close to roads. | The aim of study was to determine the phytoextraction of rare earth elements (REEs) to roots, stems and leaves of five herbaceous plant species (Achillea millefolium L., Artemisia vulgaris L., Papaver rhoeas L., Taraxacum officinale AND Tripleurospermum inodorum), growing in four areas located in close proximity to a r... | ['Metals, Rare Earth', 'Plant Leaves', 'Plant Roots', 'Plants', 'Soil', 'Soil Pollutants', 'Vehicle Emissions'] | 28,411,316 | [['D01.268.558', 'D01.552.550'], ['A18.024.812'], ['A18.400'], ['B01.650'], ['D20.721', 'G01.311.820', 'G16.500.275.815', 'N06.230.600'], ['D27.888.284.756'], ['D20.832']] | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Group II intron ribozymes that cleave DNA and RNA linkages with similar efficiency, and lack contacts with substrate 2'-hydroxyl groups. | BACKGROUND: Group II introns are self-splicing RNAs that have mechanistic similarity to the spliceosome complex involved in messenger RNA splicing in eukaryotes. These autocatalytic molecules can be reconfigured into highly specific, multiple-turnover ribozymes that cleave oligonucleotides in trans. We set out to use a... | ['Animals', 'DNA', 'Hydroxylation', 'Introns', 'Kinetics', 'Nucleotide Mapping', 'Plasmids', 'RNA', 'RNA Splicing', 'RNA, Bacterial', 'RNA, Catalytic', 'RNA, Messenger', 'Tetrahymena'] | 9,383,483 | [['B01.050'], ['D13.444.308'], ['G02.111.385', 'G02.607.348', 'G03.425'], ['G05.360.340.024.220.400', 'G05.360.340.024.340.137.515'], ['G01.374.661', 'G02.111.490'], ['E05.196.181.400.454.655', 'E05.196.401.319.670', 'E05.196.680'], ['G05.360.600'], ['D13.444.735'], ['G02.111.760.700', 'G03.839.700', 'G05.308.700.700']... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Direct screening of malonylginsenosides from nine Ginseng extracts by an untargeted profiling strategy incorporating in-source collision-induced dissociation, mass tag, and neutral loss scan on a hybrid linear ion-trap/Orbitrap mass spectrometer coupled to ultra-high performance liquid chromatography. | Specific analytical approaches that enable untargeted profiling of modified metabolites are in great need. An untargeted profiling strategy, by integrating in-source collision-induced dissociation (ISCID)-MS1, mass tag-MS2, and neutral loss scan-MS3, is established on a linear ion-trap/Orbitrap mass spectrometer couple... | ['Chromatography, High Pressure Liquid', 'Flowers', 'Ginsenosides', 'Panax', 'Plant Leaves', 'Plant Roots', 'Spectrometry, Mass, Electrospray Ionization'] | 30,146,372 | [['E05.196.181.400.300'], ['A18.024.249.500'], ['D02.455.849.919.277', 'D09.408.782.300'], ['B01.650.940.800.575.912.250.087.500'], ['A18.024.812'], ['A18.400'], ['E05.196.566.600']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Sequential change in action potential of rabbit epicardium during and following radiofrequency ablation. | INTRODUCTION: Although radiofrequency (RF) catheter ablation is used to treat certain cardiac arrhythmias, little is known regarding transient changes in cellular electrophysiology during and following RF delivery. Optical recordings of action potential (OAP) with voltage-sensitive dyes allow immunity from electrical n... | ['Action Potentials', 'Animals', 'Arrhythmias, Cardiac', 'Catheter Ablation', 'Electrophysiology', 'Pericardium', 'Rabbits'] | 10,517,659 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['B01.050'], ['C14.280.067', 'C23.550.073'], ['E02.808.750.500', 'E04.014.760.500'], ['H01.158.344.528', 'H01.158.782.236'], ['A07.541.795', 'A10.615.789.470'], ['B01.050.150.900.649.313.968.700']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Protection against pressure overload-induced right heart failure by uncoupling protein 2 silencing. | AIMS: The role of uncoupling protein 2 (UCP2) in cardiac adaptation to pressure overload remains unclear. In a classical model of left ventricular pressure overload genetic deletion of UCP2 (UCP2-/-) protected against cardiac hypertrophy and failure. However, in UCP2-/- mice increased proliferation of pulmonary arteria... | ['Animals', 'Cells, Cultured', 'Collagen Type I', 'Disease Models, Animal', 'Fibroblasts', 'Fibrosis', 'Gene Silencing', 'Heart Failure', 'Hypertension, Pulmonary', 'Hypertrophy, Right Ventricular', 'Male', 'Mice, Inbred C57BL', 'Mice, Knockout', 'Mitochondria, Heart', 'Myocytes, Cardiac', 'Reactive Oxygen Species', 'U... | 30,850,841 | [['B01.050'], ['A11.251'], ['D05.750.078.280.300.100', 'D12.776.860.300.250.300.100'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['A11.329.228'], ['C23.550.355'], ['G05.308.203.374'], ['C14.280.434'], ['C08.381.423', 'C14.907.489.556'], ['C14.280.195.410', 'C23.300.775.250.401'], ['B01.050.050.199.520.520.420', 'B... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Recombinant gamma interferon is a potent adjuvant for a malaria vaccine in mice. | Mice were protected against lethal Plasmodium yoelii malaria by vaccination with a Triton X-100 lysate of whole parasitized erythrocytes. For full effectiveness this vaccine required an adjuvant, and we have found that recombinant gamma-interferon has strong adjuvanticity in this model when given either intraperitoneal... | ['Adjuvants, Immunologic', 'Animals', 'Antigens', 'Antigens, Protozoan', 'Female', 'Histocompatibility Antigens Class II', 'Hypersensitivity, Delayed', 'Interferon-gamma', 'Malaria', 'Male', 'Mice', 'Recombinant Proteins', 'Vaccines, Synthetic'] | 3,113,784 | [['D27.505.696.477.067'], ['B01.050'], ['D23.050'], ['D23.050.293'], ['D12.776.395.550.509', 'D12.776.543.550.440', 'D23.050.301.500.400', 'D23.050.705.552.410'], ['C20.543.418'], ['D12.644.276.374.440.893', 'D12.644.276.374.480.615.350', 'D12.776.467.374.440.893', 'D12.776.467.374.480.615.350', 'D23.529.374.440.893', ... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
DNA detection using functionalized conducting polymers. | A well-defined DNA bioconjugated surface is a key component in the development of efficient biosensor platforms for diseases, ranging from point-of-care detection of pathogens and viruses to personalized diagnostics and medication, as well as for drug discovery, forensics, and food technology. We herein describe a univ... | ['Biosensing Techniques', 'Biotin', 'Bridged Bicyclo Compounds, Heterocyclic', 'Carboxylic Acids', 'DNA', 'Electric Conductivity', 'Electrochemistry', 'Oligodeoxyribonucleotides', 'Optical Phenomena', 'Polymers', 'Pyrroles', 'Silanes', 'Spectrometry, Fluorescence', 'Thiophenes'] | 21,674,347 | [['E05.601.043'], ['D03.383.129.308.080', 'D08.211.096'], ['D03.605.084'], ['D02.241'], ['D13.444.308'], ['G01.358.500.249.277'], ['H01.181.529.307'], ['D13.695.578.424.450'], ['G01.590'], ['D05.750', 'D25.720', 'J01.637.051.720'], ['D03.383.129.578'], ['D01.837.700'], ['E05.196.712.516.600.676', 'E05.196.867.726'], ['... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
[Isotopic method in the demonstration of diaphragmatic defects in a case of pleural effusion associated with cirrhosis: apropos of a case]. | A 62-year-old woman presented with massive right-sided hydrothorax associated with cirrhosis of the liver. Chest scintigraphy after intraperitoneal injection of labelled tracer showed movement of the tracer from the peritoneal to the pleural cavity. Medical therapy and thoracocentesis were successful in this case. | ['Female', 'Humans', 'Hydrothorax', 'Liver Cirrhosis, Alcoholic', 'Middle Aged', 'Pleural Effusion', 'Radionuclide Imaging', 'Technetium Tc 99m Aggregated Albumin'] | 1,755,275 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['C08.528.476'], ['C06.552.630.380', 'C06.552.645.590', 'C23.550.355.412.380', 'C25.775.100.087.645.550'], ['M01.060.116.630'], ['C08.528.652'], ['E01.370.350.710', 'E01.370.384.730'], ['D02.691.825.375', 'D12.776.034.900']] | ['Organisms [B]', 'Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Overexpression of the CD155 gene in human colorectal carcinoma. | BACKGROUND AND AIMS: The Tage4 gene (tumour associated glycoprotein E4) is overexpressed in rat colon tumours and Min mouse intestinal adenomas. The rat Tage4 protein has approximately 40% identity with human CD155, a member of the immunoglobulin superfamily coding for a transmembrane protein capable of serving as an e... | ['Adenocarcinoma', 'Adenoma', 'Adult', 'Aged', 'Aged, 80 and over', 'Alternative Splicing', 'Antibodies, Monoclonal', 'Blotting, Western', 'Colorectal Neoplasms', 'Electrophoresis, Agar Gel', 'Electrophoresis, Polyacrylamide Gel', 'Female', 'Flow Cytometry', 'Humans', 'Male', 'Membrane Proteins', 'Middle Aged', 'Oligon... | 11,454,801 | [['C04.557.470.200.025'], ['C04.557.470.035'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['G02.111.760.700.100', 'G03.839.700.100', 'G05.308.700.700.100'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.... | ['Diseases [C]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Molecular neuroimaging in primary progressive aphasia with predominant agraphia. | A 62-year-old male presented with progressive isolated writing and spelling difficulties. Neurological, neuropsychological, speech, and language evaluations identified only minimal additional abnormalities. The presenting characteristics did not meet criteria for any particular variant of primary progressive aphasia; h... | ['Agraphia', 'Aphasia, Primary Progressive', 'Brain', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Positron-Emission Tomography'] | 29,569,990 | [['C10.597.606.150.500.050', 'C23.888.592.604.150.500.050'], ['C10.228.140.380.132', 'C10.597.606.150.500.800.100.155', 'C23.888.592.604.150.500.800.100.155', 'F03.615.400.125'], ['A08.186.211'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['M01.060.116.630'], ['E01.370.350.350.800.700', '... | ['Diseases [C]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]'] | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Beta2-adrenoceptor-mediated prejunctional facilitation and postjunctional inhibition of sympathetic neuroeffector transmission in the guinea pig vas deferens. | This study examines the role of prejunctional and postjunctional beta-adrenoceptors in the modulation of sympathetic cotransmission in the guinea pig vas deferens. The prejunctional involvement of beta-adrenoceptors was evaluated by testing the effects of several agonists and antagonists on the nerve stimulation-evoked... | ['Adenosine Triphosphate', 'Adrenergic alpha-Agonists', 'Adrenergic beta-Agonists', 'Animals', 'Chromatography, High Pressure Liquid', 'Electric Stimulation', 'Guinea Pigs', 'In Vitro Techniques', 'Male', 'Muscle Contraction', 'Neuroeffector Junction', 'Norepinephrine', 'Receptors, Adrenergic, beta-2', 'Receptors, Pres... | 11,454,924 | [['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['D27.505.519.625.050.100.100', 'D27.505.696.577.050.100.100'], ['D27.505.519.625.050.100.200', 'D27.505.696.577.050.100.200'], ['B01.050'], ['E05.196.181.400.300'], ['E05.723.402'], ['B01.050.150.900.649.313.992.550'], ['E05.481'], ['G11.4... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Evaluation of a dimeric inhibin-A assay for assessing fetal Down syndrome: establishment, comparison, and monitoring of median concentrations for normal pregnancies. | CONTEXT: Several studies report the role of dimeric inhibin-A in assessing risk for fetal Down syndrome. The majority, however, use the Serotec inhibin-A assay and not the newer Diagnostic Systems Laboratories inhibin-A enzyme-linked immunosorbent assay (ELISA).OBJECTIVES: To establish normal gestational age day-specif... | ['Biomarkers', 'Chorionic Gonadotropin', 'Dimerization', 'Down Syndrome', 'Enzyme-Linked Immunosorbent Assay', 'Estriol', 'Female', 'Fetal Diseases', 'Gestational Age', 'Humans', 'Inhibins', 'Predictive Value of Tests', 'Pregnancy', 'Pregnancy Trimester, Second', 'Prenatal Diagnosis', 'Reagent Kits, Diagnostic', 'Refer... | 15,043,467 | [['D23.101'], ['D06.472.699.322.326', 'D06.472.699.649.367', 'D12.644.548.726.367', 'D12.776.780.400'], ['G02.206', 'G03.230'], ['C10.597.606.360.220', 'C16.131.077.327', 'C16.131.260.260', 'C16.320.180.260'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Improved Nonenzymatic Glucose Sensing Properties of Pd/MnO2 | The electrocatalytic properties of manganese oxide (MnO2) can be improved significantly by making hybrids/composites with noble metals (Au, Pd). Here, efforts have been made to synthesize the MnO2/Au and MnO2/Pd nanocomposites by a facile, rapid microwave irradiation method. The products characterized by X-ray diffract... | ['Biosensing Techniques', 'Catalysis', 'Electrochemical Techniques', 'Electrodes', 'Glucose', 'Gold', 'Lead', 'Manganese Compounds', 'Nanocomposites', 'Oxidation-Reduction', 'Oxides'] | 29,985,615 | [['E05.601.043'], ['G02.130'], ['E05.301'], ['E07.305.250'], ['D09.947.875.359.448'], ['D01.268.556.322', 'D01.268.956.186', 'D01.552.544.322'], ['D01.268.556.435', 'D01.552.544.435'], ['D01.530'], ['J01.637.512.150'], ['G02.700', 'G03.295.531'], ['D01.248.497.158.685', 'D01.650.550']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Cell culture on microfabricated one-dimensional polymeric structures for bio-actuator and bio-bot applications. | Here, we present the development, characterization and quantification of a novel 1D/2D like polymeric platform for cell culture. The platform consists of a 2D surface anchoring a long (few millimeters) narrow filament (1D) with a single cell scale (micro scale) cross section. We plate C2C12 cells on the platform and ch... | ['Actins', 'Animals', 'Biomimetics', 'Cell Culture Techniques', 'Cell Differentiation', 'Cell Movement', 'Cell Nucleus', 'Cell Proliferation', 'Dimethylpolysiloxanes', 'Mice', 'Microtechnology', 'Mitosis', 'Muscle Fibers, Skeletal'] | 25,712,193 | [['D05.750.078.730.250', 'D12.776.210.500.100', 'D12.776.220.525.255'], ['B01.050'], ['H01.158.550.100', 'J01.897.120.100'], ['E01.370.225.500.223', 'E05.200.500.265', 'E05.242.223', 'E05.481.500.249'], ['G04.152'], ['G04.198', 'G07.568.500.180'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['G04.161.750', 'G07... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Exploring the cytoskeleton during intracytoplasmic sperm injection in humans. | Understanding the cellular events during fertilization in mammals is a major challenge that can contribute to the improvement of future infertility treatments in humans and reproductive performance in farm animals. Of special interest is the role of the oocyte and sperm cytoskeleton during the initial interaction betwe... | ['Cytoskeleton', 'DNA', 'Fertilization', 'Humans', 'Immunohistochemistry', 'Male', 'Microscopy, Fluorescence', 'Oocytes', 'Sperm Injections, Intracytoplasmic', 'Sperm Tail', 'Tissue Fixation', 'Zygote'] | 19,085,137 | [['A11.284.430.214.190.750'], ['D13.444.308'], ['G08.686.784.277'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512', 'H01.158.201.344.512', 'H01.158.201.486.512', 'H01.181.122.5... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Evaluation of genotoxicity of Yukmijihwang-tang, a herbal formula. | Yukmijihwang-tang (Liu wei di huang tang, Rokumigan; YMJ) has been used for body enrichment; however, little toxicological evaluation of YMJ has been performed to assure its safety for clinical treatment. To increase the safety information for YMJ, its genotoxicity was evaluated. There was no increase in the number of ... | ['Animals', 'Cell Line', 'Cricetinae', 'Cricetulus', 'Drug Evaluation, Preclinical', 'Drugs, Chinese Herbal', 'Erythrocytes', 'Female', 'Male', 'Mice', 'Mice, Inbred ICR', 'Micronucleus Tests', 'Mutagenicity Tests', 'Plant Preparations'] | 21,241,764 | [['B01.050'], ['A11.251.210'], ['B01.050.150.900.649.313.992.635.075.250'], ['B01.050.150.900.649.313.992.635.075.250.250'], ['E05.290.750', 'E05.337.550'], ['D20.215.784.500.350', 'D26.335'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.510',... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Acute kidney injury after transcatheter aortic valve implantation and mortality risk-long-term follow-up. | BACKGROUND: Acute kidney injury (AKI) complicating transcatheter aortic valve implantation (TAVI) is relatively frequent and associated with significant morbidity. Previous studies have shown a higher 30-day and 1-year mortality risk in patients with periprocedural AKI. Our aim was to identify the prognostic impact of ... | ['Acute Kidney Injury', 'Aged', 'Aged, 80 and over', 'Aortic Valve Stenosis', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Middle Aged', 'Prognosis', 'Prospective Studies', 'Risk Factors', 'Survival Rate', 'Transcatheter Aortic Valve Replacement'] | 30,169,857 | [['C12.777.419.780.050', 'C13.351.968.419.780.050'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C14.280.484.048.750', 'C14.280.955.249'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.789'], ['E... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Retrospective analysis of clinical information in Crimean-Congo haemorrhagic fever patients: 2014-2015, India. | BACKGROUND & OBJECTIVES: Differential diagnosis of Crimean-Congo haemorrhagic fever (CCHF) from other acute febrile illnesses with haemorrhagic manifestation is challenging in India. Nosocomial infection is a significant mode of transmission due to exposure of healthcare workers to blood and body fluids of infected pat... | ['Adolescent', 'Adult', 'Antibodies, Viral', 'Cross Infection', 'Diagnosis, Differential', 'Enzyme-Linked Immunosorbent Assay', 'Female', 'Health Personnel', 'Hemorrhagic Fever Virus, Crimean-Congo', 'Hemorrhagic Fever, Crimean', 'Humans', 'India', 'Male', 'Middle Aged', 'Young Adult'] | 28,948,959 | [['M01.060.057'], ['M01.060.116'], ['D12.776.124.486.485.114.254', 'D12.776.124.790.651.114.254', 'D12.776.377.715.548.114.254'], ['C01.248', 'C23.550.291.875.500'], ['E01.171'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['M01.526.485', 'N02.360... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Control of singlet oxygen generation photosensitized by meso-anthrylporphyrin through interaction with DNA. | To control the activity of photosensitized singlet oxygen ((1)O(2)) generation, the electron donor-connecting porphyrin, 5-(9'-anthryl)-10,15,20-tris(p-pyridyl)porphyrin (AnTPyP), was designed and synthesized. AnTPyP became water-soluble by the protonation of the pyridyl moieties in the presence of 5 mM trifluoroacetic... | ['Anthracenes', 'Antineoplastic Agents', 'DNA', 'Electron Transport', 'Fluorescence', 'Humans', 'Light', 'Models, Molecular', 'Neoplasms', 'Oligonucleotides', 'Oxidation-Reduction', 'Photochemistry', 'Photochemotherapy', 'Photosensitizing Agents', 'Porphyrins', 'Singlet Oxygen', 'Spectrometry, Fluorescence', 'Trifluoro... | 21,466,558 | [['D02.455.426.559.847.117', 'D04.615.117'], ['D27.505.954.248'], ['D13.444.308'], ['G02.111.248', 'G03.295.531.403', 'G03.493.350'], ['G01.358.500.505.650.665.500', 'G01.590.540.665.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['E... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Organization of the albumin and alpha-fetoprotein genes in fetal and adult rat tissues, and rat hepatomas. | We compared the organization of the albumin and alpha-fetoprotein (AFP) genes in chromosomal DNA from different fetal and adult rat tissues as well as from two rat hepatomas. These two genes are expressed at widely different levels in the tissues and hepatomas analysed. Southern blots of DNAs digested with the restrict... | ['Albumins', 'Animals', 'Cell Line', 'Chromosomes', 'DNA', 'DNA Restriction Enzymes', 'Electrophoresis, Agar Gel', 'Fetus', 'Liver Neoplasms', 'Liver Neoplasms, Experimental', 'Male', 'Nucleic Acid Hybridization', 'Rats', 'Rats, Inbred BUF', 'Rats, Inbred Strains', 'alpha-Fetoproteins'] | 2,416,621 | [['D12.776.034'], ['B01.050'], ['A11.251.210'], ['A11.284.187', 'A11.284.430.106.279.345.190', 'G05.360.162'], ['D13.444.308'], ['D08.811.150.280', 'D08.811.277.352.335.350.300', 'D08.811.277.352.355.325.300'], ['E05.196.401.153', 'E05.301.300.100'], ['A16.378'], ['C04.588.274.623', 'C06.301.623', 'C06.552.697'], ['C04... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Association between quantitative MRI and ICRS arthroscopic grading of articular cartilage. | PURPOSE: To investigate the association of quantitative magnetic resonance imaging (qMRI) parameters with arthroscopic grading of cartilage degeneration. Arthroscopy of the knee is considered to be the gold standard of osteoarthritis diagnostics; however, it is operator-dependent and limited to the evaluation of the ar... | ['Adult', 'Aged', 'Arthroscopy', 'Cartilage, Articular', 'Contrast Media', 'Female', 'Gadolinium DTPA', 'Humans', 'Knee Joint', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged'] | 25,209,205 | [['M01.060.116'], ['M01.060.116.100'], ['E01.370.388.250.070', 'E04.502.250.070', 'E04.555.113'], ['A02.165.407.150', 'A02.835.583.192'], ['D27.505.259.500', 'D27.720.259'], ['D02.092.782.590.401', 'D02.241.081.018.639.400', 'D02.257.141'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.583.475'], ['E01.370... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Comparative dopamine-acetylcholine interactions in the ventral and dorsal striatum of rabbit and rat brain. | The dopamine (DA)-acetylcholine (ACh) interactions were investigated in dorsal (nucleus caudate, NC) and ventral (olfactory tubercle, OT) striatal regions, of rats and rabbits. Both regions receive a dense dopaminergic innervation and have high ACh concentrations. Brain slices of NC and OT from both animal species were... | ['Acetylcholine', 'Analysis of Variance', 'Animals', 'Apomorphine', 'Caudate Nucleus', 'Dopamine', 'Dopamine Agonists', 'Male', 'Olfactory Pathways', 'Rabbits', 'Rats', 'Rats, Sprague-Dawley', 'Receptors, Dopamine D2', 'Sulpiride', 'Tritium'] | 8,891,253 | [['D02.092.211.111'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['B01.050'], ['D03.132.098.038.290', 'D03.633.100.531.085.030.290', 'D03.633.400.095.290'], ['A08.186.211.200.885.287.249.487.550.184'], ['D02.092.211.215.406', 'D02.092.311.342', 'D02.455.426.559.389.657.166.175.342'], ['D27.505.5... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Clinical features of neurotoxic snake bite and response to antivenom in 47 children. | Among 47 children admitted to the Chulalongkorn Medical School Hospital for neurotoxic snake bite, the attackers were identified in 15; the cobra (Naja naja) was the snake involved in all cases. Clinical manifestations in all 47 children appeared to follow a similar pattern. Drowsiness heralded the systemic effects in ... | ['Antivenins', 'Child', 'Child, Preschool', 'Elapid Venoms', 'Hemoglobins', 'Humans', 'Infant', 'Leukocyte Count', 'Male', 'Neuromuscular Diseases', 'Respiration Disorders', 'Seasons', 'Snake Bites', 'Snake Venoms', 'Thailand'] | 6,507,733 | [['D12.776.124.486.485.114.573.601.138', 'D12.776.124.790.651.114.573.601.138', 'D12.776.377.715.548.114.573.601.138', 'D20.215.401.601.163'], ['M01.060.406'], ['M01.060.406.448'], ['D20.888.850.325', 'D23.946.833.850.325'], ['D12.776.124.400', 'D12.776.422.316.762'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Integrating systems approaches into pharmaceutical sciences. | During the first week of December 2007, the European Federation for Pharmaceutical Sciences (EUFEPS) and BioSim, the major European Network of Excellence on Systems Biology, held a challenging conference on the use of mathematical models in the drug development process. More precisely, the purpose of the conference was... | ['Chemistry, Pharmaceutical', 'Computer Simulation', 'Drug Industry', 'Europe', 'Genomics', 'Models, Statistical', 'Pharmacology, Clinical', 'Systems Biology'] | 18,602,464 | [['H01.158.703.007', 'H01.181.466'], ['L01.224.160'], ['J01.576.655.750'], ['Z01.542'], ['H01.158.273.180.350', 'H01.158.273.343.350'], ['E05.318.740.500', 'E05.599.835', 'N05.715.360.750.530', 'N06.850.520.830.500'], ['H01.158.703.152', 'H02.628.512'], ['H01.158.273.180.800']] | ['Disciplines and Occupations [H]', 'Information Science [L]', 'Technology, Industry, and Agriculture [J]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 |
Genetic variability of German hepatitis C virus isolates. | Heterogeneity of hepatitis C viral (HCV) genomes of several isolates from different countries has been reported, but there is little information on HCV isolates for the Federal Republic of Germany. Therefore, the nucleotide (nt) and deduced amino acid (aa) sequences of interesting parts of the viral genome derived from... | ['Amino Acid Sequence', 'Base Sequence', 'Cloning, Molecular', 'Female', 'France', 'Genes, Viral', 'Genes, env', 'Genetic Variation', 'Germany', 'Hepacivirus', 'Humans', 'Japan', 'Male', 'Molecular Sequence Data', 'Polymerase Chain Reaction', 'Sequence Homology', 'United States', 'Viral Proteins'] | 8,228,920 | [['G02.111.570.060', 'L01.453.245.667.060'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.393.220'], ['Z01.542.286'], ['G05.360.340.024.340.364.875', 'G05.360.340.358.024.875', 'G05.360.340.358.840.500'], ['G05.360.340.024.340.364.875.172', 'G05.360.340.358.024.875.172', 'G05.360.340.358.840.500.172... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 |
Performance of the 2013 American College of Rheumatology/European League Against Rheumatism Classification Criteria for Systemic Sclerosis (SSc) in large, well-defined cohorts of SSc and mixed connective tissue disease. | OBJECTIVE: To assess the 2013 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) Classification Criteria for Systemic Sclerosis (SSc) on defined subgroups of SSc and in mixed connective tissue disease (MCTD) as an SSc-related disease.METHODS: The 2013 ACR/EULAR criteria were assessed in 425... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Female', 'Humans', 'Longitudinal Studies', 'Male', 'Middle Aged', 'Mixed Connective Tissue Disease', 'Rheumatology', 'Scleroderma, Systemic', 'Sensitivity and Specificity', 'Young Adult'] | 25,274,890 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.500.750.500', 'N05.715.360.330.500.750.500', 'N06.850.520.450.500.750.500'], ['M01.060.116.630'], ['C17.300.540'], ['H02.403.429.730'], ['C17.300.799', 'C17.800.784'], ['E05.31... | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Do suffering patients turn to God? | Interpretative data from 300 Catholic hospitals and 48 interviews with Catholic health professionals suggest that patients who have always had faith will turn to God when in distress; patients who did not have faith may still not turn to God; and some patients may reject God entirely through pain and disablement. | ['Attitude of Health Personnel', 'Attitude to Death', 'Catholicism', 'Humans', 'Pain', 'Pastoral Care', 'Patients', 'Personnel, Hospital', 'Surveys and Questionnaires', 'United States'] | 10,245,427 | [['F01.100.050', 'N05.300.100'], ['F01.100.125', 'N05.300.125'], ['K01.844.188.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.888.592.612', 'F02.830.816.444', 'G11.561.790.444'], ['F02.784.176.560', 'F02.880.410'], ['M01.643'], ['M01.526.485.740', 'N02.360.740'], ['E05.318.308.980', 'N05.715.360.300.800'... | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Humanities [K]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Evidence for excitatory 5-HT2-receptors on rat brainstem neurones. | 1. The technique of microiontophoresis was used to investigate the identity of the receptor mediating the excitatory effects of 5-hydroxytryptamine (5-HT) upon neurones in the midline of the medullary brainstem of the rat in vivo. 2. The 5-HT1-like receptor agonists 5-carboxamidotryptamine (5-CT) and 8-hydroxy-2-(di-n-... | ['Action Potentials', 'Animals', 'Brain Stem', 'Ketanserin', 'Male', 'Neurons', 'Norepinephrine', 'Prazosin', 'Rats', 'Receptors, Serotonin', 'Serotonin'] | 3,395,786 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['B01.050'], ['A08.186.211.132'], ['D03.383.621.365', 'D03.633.100.786.830.333'], ['A08.675', 'A11.671'], ['D02.033.100.291.502', 'D02.092.063.480', 'D02.092.211.215.746', 'D02.092.311.830', 'D02.455.426.559.389.657.166.175.830'], ['D03.633.100.786.750'], ['B01.05... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of maternal separation, early handling, and standard facility rearing on orienting and impulsive behavior of adolescent rats. | Effects of maternal separation in rats have been extensively investigated, but no studies have examined its effects in rat adolescence. We examined the effects of neonatal infant-mother separation (MS) for 6h/day and early handling (EH) for 10 days during the first 2 weeks of life by comparing MS and EH groups to stand... | ['Age Factors', 'Animals', 'Animals, Newborn', 'Attention Deficit Disorder with Hyperactivity', 'Behavior, Animal', 'Disease Models, Animal', 'Female', 'Impulsive Behavior', 'Maternal Behavior', 'Maternal Deprivation', 'Orientation', 'Rats', 'Rats, Sprague-Dawley', 'Space Perception'] | 16,242,858 | [['N05.715.350.075', 'N06.850.490.250'], ['B01.050'], ['B01.050.050.282'], ['F03.625.094.150'], ['F01.145.113'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['F01.145.527'], ['F01.829.263.370.215'], ['F01.829.263.370.240'], ['F01.058.577', 'F02.830.606'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.90... | ['Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Functional human T cell-B cell hybridomas established from fusion of normal T cells and an EBV-transformed B cell line. | Human T cell-B cell hybridomas containing 92 chromosomes were derived by fusing normal stimulated CD-depleted T cells with the EBV-transformed human B cell line 729-HF. These hybridomas coexpressed the T cell surface markers CD3, CD8, and CD2 and the B cell surface antigens CD19, CD20, CD23, DR, and DQ. They weakly and... | ['Antigens, CD', 'B-Lymphocytes', 'Cell Fusion', 'Cell Line', 'Gene Rearrangement, T-Lymphocyte', 'Genes, Immunoglobulin', 'Herpesvirus 4, Human', 'Humans', 'Hybridomas', 'Immunoglobulins', 'Receptors, Antigen, T-Cell', 'T-Lymphocytes', 'Tetradecanoylphorbol Acetate'] | 2,152,857 | [['D23.050.301.264.035', 'D23.101.100.110'], ['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['E05.242.307', 'G04.155'], ['A11.251.210'], ['G05.344.801', 'G12.500.287'], ['G05.360.340.024.340.335', 'G12.500.299'], ['B04.280.210.400.500.450', 'B04.... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Implantation of deep brain stimulation electrodes in unshaved patients. Technical note. | Although hair removal prior to neurosurgery may increase the risk of infection, the practice of shaving the patient's entire head is still common, particularly in implant surgery. The authors describe a technique for implanting a deep brain stimulation electrode without shaving the patient's hair and present a retrospe... | ['Electric Stimulation Therapy', 'Electrodes', 'Female', 'Hair Removal', 'Humans', 'Male', 'Neurosurgery', 'Preoperative Care', 'Scalp', 'Surgical Wound Infection'] | 12,507,152 | [['E02.331', 'E02.779.468', 'E02.831.535.468'], ['E07.305.250'], ['E02.218.372'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H02.403.810.425'], ['E02.760.795', 'E04.604.750', 'N02.421.585.795'], ['A01.456.810'], ['C01.947.692', 'C23.550.767.925']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
[The complex grafting of the internal thoracic artery to the coronary arteries]. | Among the 34 complex internal thoracic artery (ITA) to coronary artery grafts, there were bilateral (in 20 patients), bifurcated (in 8), sequential (in 4), "free" (in 1), left ITA and right radial artery (in 1). It was performed with the "no-touch" technique to the ascending and transverse aorta, cardiopulmonary bypass... | ['Adult', 'Aged', 'Coronary Disease', 'Female', 'Humans', 'Internal Mammary-Coronary Artery Anastomosis', 'Male', 'Middle Aged'] | 9,173,126 | [['M01.060.116'], ['M01.060.116.100'], ['C14.280.647.250', 'C14.907.585.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.100.376.719.332.400', 'E04.100.814.868.750.400', 'E04.928.220.520.220.380'], ['M01.060.116.630']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Ca binding to the human red cell membrane: characterization of membrane preparations and binding sites. | Inside out and right side out vesicles were used to study the sidedness of Ca binding to the human red cell membrane. It was shown that these vesicles exhibited only a limited permeability to Ca, enabling the independent characterization of Ca binding to the extracellular and cytoplasmic membrane surfaces... | ['Adenosine Triphosphate', 'Binding Sites', 'Binding, Competitive', 'Calcium', 'Computers', 'Erythrocyte Membrane', 'Erythrocytes', 'Humans', 'Hydrogen-Ion Concentration', 'Kinetics', 'Potassium', 'Spectrin'] | 11,349 | [['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['G02.111.570.120'], ['E05.196.080', 'G02.111.084', 'G02.111.570.120.309'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['L01.224.230.260'], ['A11.118.290.270', 'A11.284.149.356', 'A15.145.229.334.270'], ['A11.118.290', 'A11.443.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
The 2003 outbreak of Dengue fever in Delhi, India. | Dengue fever (DF) and Dengue hemorrhagic fever (DHF) are widespread in Southeast Asia. An outbreak of DF/DHF in Delhi in 2003 started during September, reached its peak in October-November, and lasted until early December. This study describes the clinical and laboratory data of the 185 cases of DF/DHF admitted to Lok ... | ['Adolescent', 'Adult', 'Aged', 'Child', 'Dengue', 'Disease Outbreaks', 'Female', 'Humans', 'India', 'Male', 'Medical Audit', 'Middle Aged'] | 16,438,142 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.406'], ['C01.920.500.270', 'C01.925.081.270', 'C01.925.782.350.250.214', 'C01.925.782.417.214'], ['N06.850.290'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.245.393'], ['N04.761.700.250.500', 'N05.700.175.500'], ['M01.060.116.630']] | ['Named Groups [M]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
GRP94 promotes muscle differentiation by inhibiting the PI3K/AKT/mTOR signaling pathway. | The glucose-regulated endoplasmic reticulum chaperone protein 94 (GRP94) is required for many biological processes, such as secretion of immune factors and mesoderm induction. Here, we demonstrated that GRP94 promotes muscle differentiation in vitro and in vivo. Moreover, GRP94 inhibited the PI3K/AKT/mTOR signaling pat... | ['Animals', 'Cell Differentiation', 'Membrane Glycoproteins', 'Mice', 'Muscle Cells', 'Muscle, Skeletal', 'Myoblasts', 'Phosphatidylinositol 3-Kinases', 'Proto-Oncogene Proteins c-akt', 'Signal Transduction', 'TOR Serine-Threonine Kinases'] | 31,025,379 | [['B01.050'], ['G04.152'], ['D12.776.395.550', 'D12.776.543.550'], ['B01.050.150.900.649.313.992.635.505.500'], ['A11.620'], ['A02.633.567', 'A10.690.552.500'], ['A11.872.620'], ['D08.811.913.696.620.500'], ['D08.811.913.696.620.682.700.755', 'D12.776.476.565', 'D12.776.624.664.700.168'], ['G02.111.820', 'G04.835'], ['... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A multi-stage shuttle run as a predictor of running performance and maximal oxygen uptake in adults. | The aim of this study was to assess the validity of a 20 metre multi-stage shuttle run (20-MST) as both a field test of cardiorespiratory endurance and as a predictor of competitive performance in a 10 kilometre (10 km) race. Nine male subjects (age 35.4 +/- 5.8 years) (mean +/- SD) underwent a laboratory test of maxim... | ['Adult', 'Exercise Test', 'Humans', 'Male', 'Oxygen Consumption', 'Physical Endurance', 'Predictive Value of Tests', 'Running'] | 3,435,818 | [['M01.060.116'], ['E01.370.370.380.250', 'E01.370.386.700.250', 'E05.333.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G03.680'], ['G11.427.680', 'I03.450.642.845.054.600'], ['E05.318.370.800.650', 'N05.715.360.325.700.640', 'N06.850.520.445.800.650'], ['G11.427.410.568.610', 'G11.427.410.698.277.750', 'I0... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
5'-NUCLEOTIDASES OF NAJA NAJA KARACHIENSIS SNAKE VENOM: THEIR DETERMINATION, TOXICITIES AND REMEDIAL APPROACH BY NATURAL INHIBITORS (MEDICINAL PLANTS). | Present study was carried out regarding enzymatic assay for 5'-nucleotidase enzymes present in snake venom Naja naja karachiensis and to evaluate twenty eight medicinal plants as their antidotes. Elevated enzymatic activities i.e., 119, 183, 262 and 335 U/mL were observed in 10, 20, 30 and 40 µg of crude venom, respect... | ["5'-Nucleotidase", 'Animals', 'Antivenins', 'Dose-Response Relationship, Drug', 'Elapid Venoms', 'Elapidae', 'Enzyme Inhibitors', 'Plant Extracts', 'Plants, Medicinal', 'Snake Bites'] | 27,476,285 | [['D08.811.277.352.650.600.600'], ['B01.050'], ['D12.776.124.486.485.114.573.601.138', 'D12.776.124.790.651.114.573.601.138', 'D12.776.377.715.548.114.573.601.138', 'D20.215.401.601.163'], ['G07.690.773.875', 'G07.690.936.500'], ['D20.888.850.325', 'D23.946.833.850.325'], ['B01.050.150.900.833.672.125.875'], ['D27.505.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Hyaline membrane disease, birth weight, and gestational age. Effects on development in the first two years. | Mean mental and motor developmental test scores (Bayley scales) at 4, 12, and 24 months of age were determined for 161 graduates of a neonatal intensive care unit during the period 1977 through 1979. Analysis of variance for our data showed significant effects of hyaline membrane disease (HMD) on mental and motor devel... | ['Birth Weight', 'Central Nervous System Diseases', 'Child, Preschool', 'Developmental Disabilities', 'Follow-Up Studies', 'Gestational Age', 'Humans', 'Hyaline Membrane Disease', 'Infant', 'Infant, Newborn', 'Motor Skills', 'Prospective Studies'] | 6,181,674 | [['C23.888.144.186', 'E01.370.600.115.100.160.120.186', 'E05.041.124.160.750.149', 'G07.100.100.160.120.186', 'G07.345.249.314.120.186'], ['C10.228'], ['M01.060.406.448'], ['F03.625.421'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['G07.345.500.325.235.968', 'G08.686.320... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Mercury induces regional and cell-specific stress protein expression in rat kidney. | Cells respond to physiologic stress by enhancing the expression of specific stress proteins. Heat-shock proteins (hsps) and glucose-regulated proteins (grps) are members of a large superfamily of proteins collectively referred to as stress proteins. This particular stress-protein response has evolved as a cellular stra... | ['Animals', 'Antibody Specificity', 'Carrier Proteins', 'Electrophoresis, Polyacrylamide Gel', 'Fluorescent Antibody Technique, Indirect', 'HSC70 Heat-Shock Proteins', 'HSP70 Heat-Shock Proteins', 'HSP72 Heat-Shock Proteins', 'HSP90 Heat-Shock Proteins', 'Heat-Shock Proteins', 'Kidney Cortex', 'Kidney Medulla', 'Male',... | 10,696,793 | [['B01.050'], ['G12.100'], ['D12.776.157'], ['E05.196.401.402', 'E05.301.300.319'], ['E01.370.225.500.607.512.240.310', 'E01.370.225.750.551.512.240.310', 'E05.200.500.607.512.240.310', 'E05.200.750.551.512.240.310', 'E05.478.583.375.310'], ['D12.776.580.216.375.200'], ['D12.776.580.216.375'], ['D12.776.580.216.375.202... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Reduced thermogenesis in muscle and disturbed lipoprotein metabolism in relation to thyroid function in haemodialysis patients. | Muscle thermogenesis, measured by direct calorimetry on resting biopsy samples, was studied in 28 haemodialysis patients and related to thyroid function variables, plasma lipoprotein concentrations and post-heparin lipase activities. The heat production was decreased in about 40% of the patients and significantly corre... | ['Adult', 'Aged', 'Body Temperature Regulation', 'Calorimetry', 'Female', 'Humans', 'Lipase', 'Lipoprotein Lipase', 'Lipoproteins', 'Liver', 'Male', 'Middle Aged', 'Muscles', 'Renal Dialysis', 'Thyroid Gland'] | 3,576,114 | [['M01.060.116'], ['M01.060.116.100'], ['G07.110.232', 'G07.410.421', 'G16.012.500.535'], ['E05.196.131'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.277.352.100.400'], ['D08.811.277.352.100.430'], ['D10.532', 'D12.776.521'], ['A03.620'], ['M01.060.116.630'], ['A02.633', 'A10.690'], ['E02.870.300', 'E02... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The mechanism by which adenosine and cholinergic agents reduce contractility in rat myocardium. Correlation with cyclic adenosine monophosphate and receptor densities. | The adenosine analogue phenylisopropyladenosine decreased the basal and isoproterenol-stimulated contractile state of isolated rat left atria. The ED50 levels for both responses were similar, suggesting that direct and antiadrenergic effects may be mediated by the same receptor. Phenylisopropyladenosine decreased the c... | ['1-Methyl-3-isobutylxanthine', 'Adenosine', 'Adenylyl Cyclases', 'Animals', 'Cyclic AMP', 'Heart Atria', 'Heart Ventricles', 'Male', 'Methacholine Chloride', 'Methacholine Compounds', 'Myocardial Contraction', 'Parasympathomimetics', 'Phenylisopropyladenosine', 'Rats', 'Rats, Inbred Strains', 'Receptors, Adrenergic, b... | 2,581,720 | [['D03.633.100.759.758.824.751.500'], ['D03.633.100.759.590.138', 'D13.570.583.138', 'D13.570.800.096'], ['D08.811.520.650.200', 'D12.644.360.050', 'D12.776.476.050'], ['B01.050'], ['D03.633.100.759.646.138.395', 'D13.695.462.200', 'D13.695.667.138.395', 'D13.695.827.068.395'], ['A07.541.358'], ['A07.541.560'], ['D02.0... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[The use of lithium hydroxide for carbon dioxide absorption prevents formation of compound A during sevoflurane anesthesia]. | UNLABELLED: Aim of the study was the clinical investigation of sevoflurane degradation when using water-free lithiumhydroxide versus moist Dr?gersorb 800 for carbon dioxide absorption.METHODS: Concentrations of Compound A in the inspiratory gas mix and serum fluoride levels were measured in two groups of 8 patients eac... | ['Absorption', 'Anesthesia, Inhalation', 'Anesthetics, Inhalation', 'Carbon Dioxide', 'Ethers', 'Female', 'Fluorides', 'Humans', 'Hydrocarbons, Fluorinated', 'Indicators and Reagents', 'Lithium Compounds', 'Male', 'Methyl Ethers', 'Middle Aged', 'Sevoflurane', 'Temperature'] | 10,756,964 | [['G01.015', 'G02.010', 'G03.015', 'G03.787.024', 'G07.690.725.015'], ['E03.155.197.197'], ['D27.505.696.277.100.035.060', 'D27.505.954.427.210.100.035.060'], ['D01.200.200', 'D01.362.150', 'D01.650.550.200'], ['D02.355'], ['D01.248.497.158.380', 'D01.303.350.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D0... | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Named Groups [M]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Human case of gastric infection by a fourth larval stage of Pseudoterranova decipiens (Nematoda, Anisakidae). | Only three cases of human infection by anisakid nematodes have been reported in Chile since 1976. In the present case, an anisakid worm, identified as a fourth-stage Pseudoterranova decipiens larva, was removed with a gastroendoscopic biopsy clipper from the stomach of a 45 year-old man from southern Chile. The patient... | ['Animals', 'Anisakiasis', 'Anisakis', 'Endoscopy, Gastrointestinal', 'Humans', 'Male', 'Middle Aged', 'Stomach Diseases'] | 9,497,566 | [['B01.050'], ['C01.610.335.508.700.100.060', 'C01.610.432.060', 'C06.405.469.452.060'], ['B01.050.500.500.294.400.500.100.075'], ['E01.370.372.250.250', 'E01.370.388.250.250.250', 'E04.210.240.250', 'E04.502.250.250.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C06.405.748']] | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
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