Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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The paramyxovirus fusion protein forms an extremely stable core trimer: structural parallels to influenza virus haemagglutinin and HIV-1 gp41. | The paramyxovirus fusion (F) protein mediates membrane fusion. The biologically active F protein consists of a membrane distal subunit F2 and a membrane anchored subunit F1. A highly stable structure has been identified comprised of peptides derived from the simian virus 5 (SV5) F1 heptad repeat A, which abuts the hydr... | ['Dose-Response Relationship, Drug', 'HIV Envelope Protein gp41', 'Hemagglutinins, Viral', 'Kinetics', 'Models, Biological', 'Orthomyxoviridae', 'Protein Conformation', 'Recombinant Fusion Proteins', 'Respirovirus', 'Temperature'] | 10,332,733 | [['G07.690.773.875', 'G07.690.936.500'], ['D12.776.543.512.500.330', 'D12.776.964.775.325.164.200', 'D12.776.964.775.562.500.200', 'D12.776.964.970.880.325.164.200', 'D12.776.964.970.880.910.330', 'D23.050.327.520.330'], ['D12.776.964.970.880.345', 'D23.050.327.461'], ['G01.374.661', 'G02.111.490'], ['E05.599.395'], ['... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Identification of the 18S-ribosomal-DNA genotypes of Acanthamoeba isolates from the Philippines. | Cyst morphology has been commonly used to identify the free-living amoeba Acanthamoeba to subgenus level. A more accurate and consistent method, based on the sequence analysis of the gene coding for the amoeba's small-subunit ribosomal RNA (Rns), has, however, been developed. There have been no attempts to identify the... | ['Acanthamoeba', 'Acanthamoeba Keratitis', 'Animals', 'Base Sequence', 'Contact Lenses', 'DNA, Protozoan', 'Environmental Microbiology', 'Genotype', 'Molecular Sequence Data', 'Philippines', 'Phylogeny', 'RNA, Ribosomal, 18S', 'Soil Microbiology', 'Water Microbiology'] | 19,000,384 | [['B01.046.500.100.075.080'], ['C01.610.300.125', 'C01.610.752.049.203', 'C11.204.564.112', 'C11.294.725.125'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E07.632.500.276'], ['D13.444.308.442'], ['H01.158.273.540.274', 'N06.850.425'], ['G05.380'], ['L01.453.245.667'], ['Z01.252.145.671', ... | ['Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 |
Social blushing: a neuropsychiatric disorder? | Until recently, social blushing was rarely discussed in the medical literature. It was usually considered only a normal and occasional physiological reaction associated with emotions such as embarrassment brought on by social situations. This has changed in recent years with attention increasingly being paid to blushin... | ['Anxiety', 'Blushing', 'Emotions', 'Humans', 'Quality of Life'] | 27,420,477 | [['F01.470.132'], ['F01.145.209.530.136', 'F02.830.158'], ['F01.470'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I01.800', 'K01.752.400.750', 'N06.850.505.400.425.837']] | ['Psychiatry and Psychology [F]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Anodal current intensities above 40 microA interfere with current-induced axon-reflex vasodilatation in human skin. | When using iontophoresis, the 'non-specific' vasodilatation (NSV) that is observed as a result of C-fibre excitation is generally attributed to the local accumulation of protons under the anode. NSV following prolonged 100-microA anodal current application only appears after the current is stopped. Break excitation alo... | ['Adult', 'Axons', 'Electric Stimulation', 'Female', 'Forearm', 'Humans', 'Laser-Doppler Flowmetry', 'Male', 'Reflex', 'Skin', 'Time Factors', 'Vasodilation'] | 15,153,776 | [['M01.060.116'], ['A08.675.542.145', 'A11.284.180.075', 'A11.671.137', 'A11.671.501.145'], ['E05.723.402'], ['A01.378.800.585'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.370.475', 'E05.830.500'], ['E01.370.376.550.650', 'E01.370.600.550.650', 'F02.830.702', 'G11.561.731'], ['A17.815'], ['G01.910.857'... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Computed tomography: a new method for diagnosing tumor of the heart. | An unsuspected metastasis of liposarcoma of the heart was detected on a computed tomographic (CT) examination of the chest. Further CT study with i.v. contrast administration gave excellent delineation of the tumor. Compared with two-dimensional echocardiography and angiocardiography, CT was best at showing the myocard... | ['Angiocardiography', 'Diatrizoate', 'Echocardiography', 'Heart Neoplasms', 'Humans', 'Liposarcoma', 'Male', 'Middle Aged', 'Neoplasm Metastasis', 'Tomography, X-Ray Computed'] | 7,449,067 | [['E01.370.350.130.249', 'E01.370.350.700.060.050', 'E01.370.370.050.050', 'E01.370.370.380.050'], ['D02.241.223.100.400.880.270', 'D02.455.426.559.389.127.375.880.270'], ['E01.370.350.130.750', 'E01.370.350.850.220', 'E01.370.370.380.220'], ['C04.588.894.309', 'C14.280.459'], ['B01.050.150.900.649.313.988.400.112.400.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Dissociation between urine osmolality and urinary excretion of aquaporin-2 in healthy volunteers. | BACKGROUND: It has been suggested that urinary excretion of the vasopressin-dependent water channel of the kidney collecting duct, aquaporin-2 (AQP2), reflects renal vasopressin action and might be used clinically. It is unclear, however, what relation exists between urine osmolality and urinary excretion of AQP2 (UAQP... | ['Adult', 'Aquaporin 2', 'Aquaporin 6', 'Aquaporins', 'Deamino Arginine Vasopressin', 'Dehydration', 'Diuretics', 'Female', 'Furosemide', 'Humans', 'Male', 'Osmolar Concentration', 'Reference Values', 'Renal Agents', 'Saline Solution, Hypertonic', 'Urine'] | 10,910,438 | [['M01.060.116'], ['D12.776.157.530.400.500.040.437', 'D12.776.543.550.450.730.040.437', 'D12.776.543.585.400.730.040.530'], ['D12.776.157.530.400.500.040.249.750', 'D12.776.543.550.450.730.040.249.750', 'D12.776.543.585.400.730.040.249.750'], ['D12.776.157.530.400.500.040', 'D12.776.543.550.450.730.040', 'D12.776.543.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Levels and health risk assessments of particulate matters (PM2.5 | To determine the concentration of particulate matters (PM2.5 and PM10), 36 samples were collected from indoor/outdoor air of hookah caf?s (HS), cigarette caf?s (CS), both hookah and cigarette (HCS), and no-smoking building (NS) in Tehran City from December 2017 to March 2018. The mean ± SD of PM10 concentration in the ... | ['Air Pollutants', 'Air Pollution, Indoor', 'Cities', 'Environmental Exposure', 'Environmental Monitoring', 'Humans', 'Iran', 'Particulate Matter', 'Risk Assessment', 'Smoking', 'Smoking Water Pipes', 'Tobacco', 'Tobacco Products', 'Water Pipe Smoking'] | 30,656,582 | [['D27.888.284.101'], ['N06.850.460.100.080'], ['G16.500.275.069', 'N06.230.069', 'Z01.433'], ['N06.850.460.350'], ['N06.850.460.350.080', 'N06.850.780.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.245.500.350'], ['D20.633'], ['E05.318.740.600.800.715', 'N04.452.871.715', 'N05.715.360.750.625.700.69... | ['Chemicals and Drugs [D]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
[Single-layer digestive sutures. Tribute to Pierre Jourdan, its promotor]. | Since Antiquity, people have tried to suture intestinal injuries and many procedures have been imagined. In 1953, Pierre Jourdan published his book on single-layer intestinal anastamosis, which convinced all surgeons. | ['Anastomosis, Surgical', 'Digestive System', 'Gastrointestinal Diseases', 'History, 15th Century', 'History, 16th Century', 'History, 19th Century', 'History, 20th Century', 'Humans', 'Sutures'] | 10,998,807 | [['E04.035'], ['A03'], ['C06.405'], ['K01.400.475.500'], ['K01.400.475.750'], ['K01.400.504.937'], ['K01.400.504.968'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E07.858.690.820']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Humanities [K]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Calcium intake, bone mineral density, and fragility fractures: evidence from an Italian outpatient population. | This study was performed in 1000 adult Italian subjects to focus on the effects of dietary calcium intake on bone health. A higher fracture risk appears to be associated with a reduced calcium intake. An adequate daily calcium intake is recommended to counteract osteoporotic fractures.PURPOSE: The principal aim of the ... | ['Adult', 'Bone Density', 'Calcium, Dietary', 'Diet Records', 'Exercise', 'Female', 'Humans', 'Italy', 'Male', 'Middle Aged', 'Osteoporotic Fractures', 'Outpatients', 'Parathyroid Hormone', 'Risk Factors', 'Spinal Fractures', 'Vitamin D'] | 28,401,496 | [['M01.060.116'], ['G11.427.100'], ['D01.146.395'], ['N04.452.859.360'], ['G11.427.410.698.277', 'I03.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.542.489'], ['M01.060.116.630'], ['C26.404.545'], ['M01.643.630'], ['D06.472.699.590', 'D12.644.548.587'], ['E05.318.740.600.800.725', 'N05.715.350.200.700',... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Geographicals [Z]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Change pattern of somatosensory-evoked potentials after occlusion of segmental vessels: possible indicator for spinal cord ischemia. | Paraplegia was reported after occlusion of the segmental vessels during anterior spinal surgery. The aim of this study was to investigate the effect of occlusion of the segmental vessels on the somatosensory-evoked potential (SEP) monitoring and analyze its potential risk for cord ischemia. Thirty-one patients with tho... | ['Adolescent', 'Adult', 'Evoked Potentials, Somatosensory', 'Female', 'Humans', 'Male', 'Monitoring, Intraoperative', 'Scoliosis', 'Spinal Cord Ischemia', 'Thoracic Vertebrae'] | 16,193,298 | [['M01.060.057'], ['M01.060.116'], ['G07.265.216.500.400', 'G11.561.200.500.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.520.510', 'E04.510'], ['C05.116.900.800.875'], ['C10.228.854.785.650', 'C14.907.790.550'], ['A02.835.232.834.892']] | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Acoustic evaluation of pirfenidone on patients with combined pulmonary fibrosis emphysema syndrome. | The combined pulmonary fibrosis emphysema syndrome (CPFES) overall has a poor prognosis with a 5-year survival of 35-80%. Consequently, to evaluate possible positive effects on patients of novel agents as pirfenidone is relevant. However, the efficacy of pirfenidone in CPFES patients is still not well-known. In this st... | ['Acoustics', 'Anti-Inflammatory Agents, Non-Steroidal', 'Humans', 'Middle Aged', 'Pulmonary Emphysema', 'Pulmonary Fibrosis', 'Pyridones', 'Respiratory Sounds', 'Syndrome', 'Treatment Outcome'] | 28,268,982 | [['H01.671.031'], ['D27.505.696.663.850.014.040.500', 'D27.505.954.158.030', 'D27.505.954.329.030'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C08.381.495.389.750'], ['C08.381.765'], ['D03.383.725.791'], ['C23.888.852.779', 'E01.370.386.720', 'G09.772.775'], ['C23.550.288.500'], ['E01.789.... | ['Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Effects of nerve-muscle pedicle on immobile rat vocal folds in the presence of partial innervation. | OBJECTIVES: We investigated whether implantation of an ansa cervicalis nerve (ACN)-muscle pedicle into the thyroarytenoid (TA) muscle is efficacious in the presence of partial recurrent laryngeal nerve (RLN) innervation.METHODS: We studied a total of 36 rats. Twelve of the rats served as positive and negative control a... | ['Animals', 'Evoked Potentials', 'Female', 'Laryngeal Muscles', 'Nerve Transfer', 'Rats', 'Rats, Wistar', 'Recurrent Laryngeal Nerve', 'Surgical Flaps', 'Vocal Cord Paralysis', 'Vocal Cords'] | 21,250,554 | [['B01.050'], ['G07.265.216.500', 'G11.561.200.500'], ['A02.633.567.500', 'A04.329.604'], ['E04.525.550'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.900'], ['A08.800.050.050.925.450.700', 'A08.800.050.600.825.450.700', 'A08.800.800.060.920.450.700', 'A08.800.800.120.900.450.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of magnesium deficiency on strength, mass, and composition of rat femur. | Magnesium (Mg) participates in the normal formation and remodeling of bone. However, little is known about effects of Mg status on the biomechanical function of bone. We examined gross morphometry and composition as well as biomechanical properties of the femurs of male rats fed diets adequate or deficient in Mg. Compa... | ['Animals', 'Biomechanical Phenomena', 'Bone Density', 'Bone Development', 'Bone Remodeling', 'Bone and Bones', 'Calcium', 'Elasticity', 'Femur', 'Magnesium', 'Magnesium Deficiency', 'Male', 'Rats', 'Rats, Sprague-Dawley', 'Tensile Strength'] | 8,118,753 | [['B01.050'], ['G01.154.090', 'G01.374.089'], ['G11.427.100'], ['G07.345.500.325.377.625.050.500', 'G11.427.578.050.500'], ['G11.427.213', 'G16.762.150'], ['A02.835.232', 'A10.165.265'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['G01.374.590'], ['A02.835.232.043.150'], ['D01.268.552.437', 'D01.268.557.500... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Silent myocardial ischemia in patients with transient ischemic attacks]. | Given evidence that ischemic heart disease is the most frequent cause of death in patients with cerebrovascular disease, we used ergometrics to screen 80 patients with TIA for silent myocardial ischemia (SMI) at the neurological unit of Hospital Cl?nico Universitario in Zaragoza, Spain. The patients were compared with ... | ['Adult', 'Aged', 'Diabetes Complications', 'Electrocardiography', 'Exercise Test', 'Female', 'Humans', 'Hyperlipidemias', 'Ischemic Attack, Transient', 'Male', 'Middle Aged', 'Myocardial Ischemia'] | 7,803,050 | [['M01.060.116'], ['M01.060.116.100'], ['C19.246.099'], ['E01.370.370.380.240', 'E01.370.405.240'], ['E01.370.370.380.250', 'E01.370.386.700.250', 'E05.333.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C18.452.584.500.500'], ['C10.228.140.300.150.836', 'C14.907.253.092.836'], ['M01.060.116.630'], ['C14.280.... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Retinal photoreceptor fine structure in the short-tailed stingray (Dasyatis brevicaudata). | The fine structure of the retinal photoreceptors has been studied by light and electron microscopy in the short-tailed stingray (Dasyatis brevicaudata). The duplex retina of this elasmobranch contains rods and cones in a ratio of about 10:1. No multiple receptors were noted nor was a repeating or mosaic arrangement of ... | ['Adaptation, Physiological', 'Animals', 'Cell Nucleus', 'Light', 'Organelles', 'Photoreceptor Cells', 'Retina', 'Retinal Cone Photoreceptor Cells', 'Retinal Rod Photoreceptor Cells', 'Skates, Fish'] | 7,981,499 | [['G07.025', 'G16.012.500'], ['B01.050'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['A11.284.430.214.190.875'], ['A08.675.650.850.625', 'A08.675.650.915.937', 'A08.800.950.937', 'A09.371.729.831.625', 'A11.671.650.850.625', 'A11.67... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Depletion of central catecholamines reduces pressor responses to arginine vasopressin. | Previous reports that central administration of arginine vasopressin (AVP) increases turnover of brain catecholamines raise the possibility that the pressor responses which follow central administration of AVP may be mediated, in part, by central catecholamines. To test this hypothesis, rats were given intraventricular... | ['Animals', 'Arginine Vasopressin', 'Blood Pressure', 'Brain', 'Catecholamines', 'Heart Rate', 'Hydroxydopamines', 'Injections, Intraventricular', 'Male', 'Oxidopamine', 'Rats', 'Rats, Inbred Strains'] | 3,125,946 | [['B01.050'], ['D06.472.699.631.692.781.100', 'D12.644.400.900.100', 'D12.644.456.925.100', 'D12.644.548.691.692.781.100', 'D12.776.631.650.937.100'], ['E01.370.600.875.249', 'G09.330.380.076'], ['A08.186.211'], ['D02.092.311', 'D02.455.426.559.389.657.166.175'], ['E01.370.600.875.500', 'G09.330.380.500'], ['D02.092.31... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Defect interactions and ionic transport in scandia stabilized zirconia. | Classical molecular dynamics simulation has been used to study ionic transport in scandia-stabilized zirconia, as well as scandia and yttria-co-doped zirconia, as a function of temperature and composition. The oxygen diffusion coefficient shows a peak at a composition of 6 mol% Sc(2)O(3). At 1125 K and higher temperatu... | ['Computer Simulation', 'Ion Transport', 'Ions', 'Models, Molecular', 'Scandium', 'Thermodynamics', 'Zirconium'] | 19,551,221 | [['L01.224.160'], ['G03.143.500'], ['D01.248.497'], ['E05.599.595'], ['D01.268.558.800', 'D01.268.956.827', 'D01.552.550.800'], ['G01.906'], ['D01.268.556.950', 'D01.268.956.937', 'D01.552.544.950']] | ['Information Science [L]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Possible role of placental leucine aminopeptidase in the antiproliferative effect of oxytocin in human endometrial adenocarcinoma. | PURPOSE: Oxytocin (OT) was reported to inhibit the proliferation of various neoplastic tissues and cells, however, the regulation system remains unclear. This study examined the role of OT and its regulatory ability in endometrial adenocarcinoma.EXPERIMENTAL DESIGN: To investigate the possible function of placental leu... | ['Adenocarcinoma', 'Blotting, Western', 'Cell Division', 'Cell Line, Tumor', 'Cyclic AMP', 'Cyclic AMP-Dependent Protein Kinases', 'Cystinyl Aminopeptidase', 'DNA, Complementary', 'Dose-Response Relationship, Drug', 'Endometrial Neoplasms', 'Female', 'Humans', 'Immunoblotting', 'Immunohistochemistry', 'Oxytocin', 'Pept... | 12,684,429 | [['C04.557.470.200.025'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.251.210.190', 'A11.251.860.180'], ['D03.633.100.759.646.138.395', 'D13.695.462.200', 'D13.695.667.138.395', 'D13.... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Compared outcomes after percutaneous pinning versus open reduction in paediatric supracondylar elbow fractures. | BACKGROUND: Supracondylar fractures of the elbow are common in children. Their treatment is controversial when displacement has occurred, although percutaneous pinning is usually advocated.HYPOTHESIS: In paediatric extension-type supracondylar fractures of the elbow, percutaneous pinning and crossed K-wire fixation aft... | ['Adolescent', 'Bone Nails', 'Bone Wires', 'Child', 'Child, Preschool', 'Elbow Joint', 'Female', 'Fracture Fixation, Internal', 'Humans', 'Humeral Fractures', 'Male', 'Retrospective Studies', 'Treatment Outcome'] | 22,981,702 | [['M01.060.057'], ['E07.695.370.249', 'E07.858.442.660.460.249', 'E07.858.690.725.460.249'], ['E07.695.370.468', 'E07.858.442.660.460.468', 'E07.858.690.725.460.468'], ['M01.060.406'], ['M01.060.406.448'], ['A02.835.583.290'], ['E04.555.300.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C26.088.390', 'C26.40... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Radiographic evaluation of marginal bone level around internal-hex implants with switched platform: a clinical case report series. | PURPOSE: The purpose of this retrospective investigation was to evaluate the influence on the adjacent cervical bone of moving the implant-abutment microgap inward from the outer edge of an internal-hex implant platform (ie, a platform-switched configuration).MATERIALS AND METHODS: A convenience sample of 26 patients r... | ['Adult', 'Aged', 'Alveolar Bone Loss', 'Alveolar Process', 'Bone Remodeling', 'Dental Abutments', 'Dental Implantation, Endosseous', 'Dental Implants', 'Dental Prosthesis Design', 'Dental Prosthesis, Implant-Supported', 'Follow-Up Studies', 'Humans', 'Middle Aged', 'Radiography', 'Retrospective Studies'] | 21,691,606 | [['M01.060.116'], ['M01.060.116.100'], ['C05.116.264.150', 'C07.465.714.354.500'], ['A02.835.232.781.324.502.125', 'A14.521.125', 'A14.549.167.646.094'], ['G11.427.213', 'G16.762.150'], ['E06.780.346.500', 'E07.695.190.175'], ['E04.545.550.280.280', 'E04.650.230.500', 'E06.645.550.280.280', 'E06.780.314.310'], ['D25.33... | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Defective inflammatory response in interleukin 6-deficient mice. | Systemic and localized inflammation elicit a number of host responses which include fever, cachexia, hypoglycemia, and major changes in the concentration of liver plasma proteins. Interleukin 6 (IL-6) is considered an important mediator of the inflammatory response, together with IL-1 and tumor necrosis factor alpha (T... | ['Acute-Phase Reaction', 'Animals', 'Anorexia', 'Corticosterone', 'Hypoglycemia', 'Inflammation', 'Interleukin-1', 'Interleukin-6', 'Lipopolysaccharides', 'Liver', 'Mice', 'Serum Amyloid A Protein', 'Tumor Necrosis Factor-alpha', 'Turpentine'] | 7,931,061 | [['C23.550.470.099'], ['B01.050'], ['C23.888.821.108'], ['D04.210.500.745.745.654.237', 'D06.472.040.585.353.237'], ['C18.452.394.984'], ['C23.550.470'], ['D12.644.276.374.465.010', 'D12.644.276.374.500.400', 'D12.776.467.374.465.010', 'D12.776.467.374.500.400', 'D23.529.374.465.131', 'D23.529.374.500.400'], ['D12.644.... | ['Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The jumping to conclusions bias in delusions: specificity and changeability. | There are indications that a jumping to conclusions bias (JTC) plays a role in the formation and maintenance of delusions and should be targeted in therapy. However, it is unclear whether (a) JTC is uniquely associated with delusions or simply an epiphenomenon of schizophrenia or impaired intellectual functioning and (... | ['Adult', 'Cognition Disorders', 'Decision Making', 'Delusions', 'Diagnostic and Statistical Manual of Mental Disorders', 'Female', 'Humans', 'Male', 'Neuropsychological Tests', 'Schizophrenia', 'Severity of Illness Index'] | 20,141,241 | [['M01.060.116'], ['F03.615.250'], ['F02.463.785.373'], ['F01.145.126.200'], ['L01.453.245.945.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F04.711.513'], ['F03.700.750'], ['E05.318.308.980.438.475.456.500', 'N05.715.360.300.800.438.375.364.500', 'N06.850.520.308.980.438.475.364.500']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
The effect of serum creatinine method choice on estimated glomerular filtration rate determined by the abbreviated MDRD formula. | BACKGROUND: The aim of this study was to measure the variability in estimated glomerular filtration rate (eGFR) calculated by laboratories in Northern Ireland where creatinine assays other than the Beckman CX3 assay used to derive the Modification of Diet in Renal Disease (MDRD) are utilized.METHODS: Fifty patient samp... | ['Calibration', 'Creatinine', 'Glomerular Filtration Rate', 'Humans', 'Kidney Diseases', 'Metabolic Clearance Rate'] | 16,704,759 | [['E05.978.155'], ['D03.383.129.308.207'], ['E01.370.390.400.300', 'G08.852.357'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.777.419', 'C13.351.968.419'], ['E01.370.225.843', 'E05.200.843', 'G03.490', 'G07.690.595', 'G07.690.725.513']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Submental Muscle Activation During Lingual Tasks in Healthy Adults. | OBJECTIVE: Lingual strengthening exercises are established to improve lingual function, thereby oral swallowing. This study measured submental muscle activation during maximum isometric pressure (MIP) lingual tasks in healthy adults, tasks that are or can be adopted in lingual strengthening exercises. In addition, the ... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Deglutition', 'Deglutition Disorders', 'Exercise Therapy', 'Female', 'Healthy Volunteers', 'Humans', 'Male', 'Middle Aged', 'Tongue', 'Young Adult'] | 30,379,315 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['G10.261.178'], ['C06.405.117.119', 'C09.775.174'], ['E02.760.169.063.500.387', 'E02.779.483', 'E02.831.535.483'], ['M01.774.500', 'M01.955.236'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['A03.556.500.885', '... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Bantu expansion shows that habitat alters the route and pace of human dispersals. | Unlike most other biological species, humans can use cultural innovations to occupy a range of environments, raising the intriguing question of whether human migrations move relatively independently of habitat or show preferences for familiar ones. The Bantu expansion that swept out of West Central Africa beginning ?5,... | ['Africa South of the Sahara', 'Bayes Theorem', 'Computer Simulation', 'Cultural Evolution', 'Ecosystem', 'History, Ancient', 'Human Migration', 'Humans', 'Language', 'Models, Genetic', 'Phylogeography', 'Spatial Behavior', 'Time Factors'] | 26,371,302 | [['Z01.058.290'], ['E05.318.740.600.200', 'N05.715.360.750.625.150', 'N06.850.520.830.600.200'], ['L01.224.160'], ['I01.076.201.450.370'], ['G16.500.275.157', 'N06.230.124'], ['K01.400.470'], ['I01.240.600.525', 'N01.224.625.525', 'N06.850.505.400.700.525'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.20... | ['Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Information Science [L]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]', 'Humanities [K]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Disciplines and ... | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 |
Clinical significance of serum anti-annexin V antibodies in Egyptian patients with scleroderma. | The pathogenesis of scleroderma encompasses vascular, immunological, and fibrotic processes, which contribute to clinical manifestations. We investigated the prevalence of anti-annexin V IgG and IgM antibodies in sera of scleroderma patients and their relation to the presence of other antibodies and development of dise... | ['Adult', 'Annexin A5', 'Autoantibodies', 'Centromere', 'Egypt', 'Female', 'Humans', 'Immunoglobulin G', 'Immunoglobulin M', 'Male', 'Middle Aged', 'Scleroderma, Diffuse'] | 20,726,317 | [['M01.060.116'], ['D12.776.157.125.050.100'], ['D12.776.124.486.485.114.323', 'D12.776.124.790.651.114.323', 'D12.776.377.715.548.114.323'], ['A11.284.430.106.279.345.190.160.165', 'G05.360.160.165'], ['Z01.058.266.317'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.124.486.485.114.619.393', 'D12.776.124... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
Optimized translation of microbubbles driven by acoustic fields. | The problem of a single acoustically driven bubble translating unsteadily in a fluid is considered. The investigation of the translation equation identifies the inverse Reynolds number as a small perturbation parameter. The objective is to obtain a closed-form, leading order solution for the translation of the bubble, ... | ['Acoustics', 'Models, Statistical', 'Pressure', 'Viscosity'] | 18,397,000 | [['H01.671.031'], ['E05.318.740.500', 'E05.599.835', 'N05.715.360.750.530', 'N06.850.520.830.500'], ['G01.374.715'], ['G02.930']] | ['Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
New Design for an Adjustable Cise Space Maintainer. | Objective: The aim of this study is to present a new adjustable Cise space maintainer for preventive orthodontic applications.Methods: Stainless steel based new design consists of six main components. In order to understand the major displacement and stress fields, structural analysis for the design is considered by us... | ['Composite Resins', 'Dental Bonding', 'Finite Element Analysis', 'Humans', 'Molar', 'Orthodontic Brackets', 'Stainless Steel'] | 29,854,764 | [['D05.750.716.822.308', 'D25.339.816.500', 'D25.720.716.822.308', 'J01.637.051.339.816.500', 'J01.637.051.720.716.822.308'], ['E06.095'], ['E05.355'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A14.549.167.860.525'], ['E06.658.453.255.500'], ['D01.490.800.900', 'D01.552.033.847.681', 'D25.058.807.681', 'J01.63... | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Mentally handicapped institutionalized patients: a five-year review of gynecologic examinations performed under general anesthesia. | The validity of the practice of routine examination of mentally handicapped women under general anesthesia was evaluated via a retrospective chart review at Yale New Haven hospital for a five-year period. In the absence of a history of abnormal bleeding or discharge, this select population of low risk women had a zero ... | ['Adult', 'Aged', 'Female', 'Genital Diseases, Female', 'Humans', 'Institutionalization', 'Intellectual Disability', 'Middle Aged', 'Persons with Mental Disabilities', 'Retrospective Studies'] | 11,908,190 | [['M01.060.116'], ['M01.060.116.100'], ['C13.351.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.760.415', 'N02.421.585.415'], ['C10.597.606.360', 'C23.888.592.604.646', 'F01.700.687', 'F03.625.539'], ['M01.060.116.630'], ['M01.150.600'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A prospective comparison of cardiac rehabilitation enrollment following automatic vs usual referral. | OBJECTIVE: Cardiac rehabilitation remains grossly under-utilized despite its proven benefits. This study prospectively compared verified cardiac rehabilitation enrollment following automatic vs usual referral, postulating that automatic referral would result in significantly greater enrollment for cardiac rehabilitatio... | ['Adult', 'Aged', 'Coronary Disease', 'Female', 'Follow-Up Studies', 'Health Services Accessibility', 'Humans', 'Male', 'Middle Aged', 'Patient Acceptance of Health Care', 'Patient Compliance', 'Prospective Studies', 'Referral and Consultation', 'Socioeconomic Factors', 'Surveys and Questionnaires', 'Syndrome'] | 17,468,793 | [['M01.060.116'], ['M01.060.116.100'], ['C14.280.647.250', 'C14.907.585.250'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['N04.590.374.350', 'N05.300.430'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['F01.100.150.750.500', 'F01.145.488.887.500... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Measurement of hydration in the stratum corneum with the MoistureMeter and comparison with the Corneometer. | BACKGROUND/PURPOSE: MoistureMeter is a novel capacitive device for measuring the hydration of stratum corneum (SC). The capacitor 'plates' are formed by the probe material and the well-conducting epidermal-dermal skin layers, while the dry layer of SC acts as an 'insulator' of the capacitor. Due to this measurement pri... | ['Body Water', 'Calibration', 'Electrodiagnosis', 'Forearm', 'Galvanic Skin Response', 'Humans', 'Models, Biological', 'Sensitivity and Specificity', 'Skin', 'Skin Diseases'] | 14,731,246 | [['A12.207.200'], ['E05.978.155'], ['E01.370.405'], ['A01.378.800.585'], ['E05.796.332', 'F02.830.702.315', 'F04.669.332', 'G07.265.563', 'G13.750.415'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.395'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700', 'N05.715.360.750.725', 'N06... | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Effect of lithium carbonate on the peripheral leukocyte count in children suffering from haematological malignancies. | Effects of lithium carbonate on peripheral white blood cell and granulocyte counts were investigated in children treated for acute lymphoblastic leukaemia and non-Hodgkin malignant lymphoma. Li2CO3 given orally for two weeks in a single daily dose of 700 mg/m2 caused a significant and lasting increase in the peripheral... | ['Acute Disease', 'Child', 'Child, Preschool', 'Female', 'Granulocytes', 'Humans', 'Leukemia, Lymphoid', 'Leukocyte Count', 'Leukocytes', 'Lithium', 'Lithium Carbonate', 'Lymphoma, Non-Hodgkin', 'Male'] | 6,416,273 | [['C23.550.291.125'], ['M01.060.406'], ['M01.060.406.448'], ['A11.118.637.415', 'A11.148.350', 'A11.627.340', 'A15.145.229.637.415', 'A15.378.316.340', 'A15.382.490.315'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.337.428', 'C15.604.515.560', 'C20.683.515.528'], ['E01.370.225.500.195.107.595', 'E01.370... | ['Diseases [C]', 'Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Delivery of dsRNA with lactic acid bacteria for RNA interference. | RNA interference (RNAi) mechanism is promising for gene-targeted therapy. In this study, Lactobacillus casei were engineered to produce long double-stranded RNA (dsRNA) or short hairpin RNA (shRNA) for RNAi-delivery to the intestine. We prepared two kinds of L. casei; one produces shRNA which works in mammalian cells, ... | ['Administration, Oral', 'Animals', 'Caenorhabditis elegans', 'Genetic Engineering', 'Genetic Vectors', 'Lactobacillus casei', 'Polymerase Chain Reaction', 'RNA Interference', 'RNA, Double-Stranded', 'RNA, Untranslated'] | 18,029,762 | [['E02.319.267.100'], ['B01.050'], ['B01.050.500.500.294.400.875.660.250.250'], ['E05.393.420'], ['G05.360.337'], ['B03.353.750.450.475.225', 'B03.510.460.400.410.475.475.225', 'B03.510.550.450.475.225'], ['E05.393.620.500'], ['G05.308.203.374.790'], ['D13.444.735.490', 'G02.111.570.820.486.775', 'G05.360.580.775'], ['... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[The analysis of prognostic variables in 123 patients with multiple myeloma]. | OBJECTIVE: To assess the prognostic value of biological features and therapy-related factors in multiple myeloma (MM).METHODS: 123 patients with newly diagnosed MM between January 1998 and May 2005 were enrolled in this retrospective study. Biological features at presentation and therapy-related factors were analysed. ... | ['Adult', 'Aged', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Middle Aged', 'Multiple Myeloma', 'Prognosis', 'Retrospective Studies', 'Risk Factors', 'Survival Analysis'] | 17,877,163 | [['M01.060.116'], ['M01.060.116.100'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C04.557.595.500', 'C14.907.454.460', 'C15.378.147.780.650', 'C15.378.463.515.460', 'C20.683.515.845', 'C20.683.780.650... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Effects of ursodeoxycholic acid in esophageal motility and the role of the mucosa. An experimental study. | Esophageal motor abnormalities are frequently found in patients with gastroesophageal reflux disease. The role of bile in reflux-induced dysmotility is still elusive. Furthermore, it is questionable weather mucosal or muscular stimulation leads to motor dysfunction. The aims of this study were to analyze (i) the effect... | ['Animals', 'Esophageal Motility Disorders', 'Esophagus', 'Gastroesophageal Reflux', 'Gastrointestinal Motility', 'Guinea Pigs', 'Male', 'Mucous Membrane', 'Peristalsis', 'Ursodeoxycholic Acid'] | 21,087,343 | [['B01.050'], ['C06.405.117.119.500'], ['A03.556.875.500'], ['C06.405.117.119.500.484'], ['G10.261.360'], ['B01.050.150.900.649.313.992.550'], ['A10.615.550'], ['G10.261.360.596'], ['D04.210.500.105.225.272.962', 'D04.210.500.221.430.342.925']] | ['Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
HLA expression in a primary uveal melanoma, its cell line, and four of its metastases. | BACKGROUND: The level of HLA expression on a tumour may influence the immunological response against this tumour, and vice versa. HLA expression was determined in a primary uveal melanoma, its metastases, and on a cell line derived from this melanoma, and the presence and type of infiltrate in tissue sections were also... | ['Aged', 'Antigens, Neoplasm', 'Female', 'Gene Expression', 'Heart Neoplasms', 'Histocompatibility Antigens Class I', 'Histocompatibility Antigens Class II', 'Humans', 'Immunohistochemistry', 'Liver Neoplasms', 'Melanoma', 'Skin Neoplasms', 'Tumor Cells, Cultured', 'Uveal Neoplasms'] | 9,505,825 | [['M01.060.116.100'], ['D23.050.285'], ['G05.297'], ['C04.588.894.309', 'C14.280.459'], ['D12.776.395.550.489', 'D12.776.543.550.439', 'D23.050.301.500.100', 'D23.050.705.552.100'], ['D12.776.395.550.509', 'D12.776.543.550.440', 'D23.050.301.500.400', 'D23.050.705.552.410'], ['B01.050.150.900.649.313.988.400.112.400.40... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Are frozen-section examinations of ureteral margins required for all patients undergoing radical cystectomy for bladder cancer? | Unsuspected malignant disease was discovered by frozen-section examination of the ureteral margins in 8 of 403 patients (2%) undergoing cystectomy for treatment of bladder cancer. Once malignant disease was demonstrated, a short segment of the proximal ureter was resected in 6 patients; in 5 instances dysplastic change... | ['Follow-Up Studies', 'Frozen Sections', 'Humans', 'Microtomy', 'Neoplasm Invasiveness', 'Ureteral Neoplasms', 'Urinary Bladder Neoplasms'] | 2,728,145 | [['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['E01.370.225.500.620.530.160.260', 'E01.370.225.750.600.530.160.260', 'E05.200.500.620.530.160.260', 'E05.200.750.600.530.160.260'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.620.530', 'E01.370.225.750.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
A randomized, double-blind, placebo-controlled trial of recombinant human alpha-interferon therapy for chronic non-A, non-B (type C) hepatitis. | The effects of alpha-interferon therapy were evaluated in a prospective, randomized, double-blind, controlled trial of recombinant human interferon alfa-2b versus placebo in patients with well-documented chronic non-A, non-B hepatitis (type C). Forty-one patients, of whom 37 (90%) had hepatitis C virus antibodies in th... | ['Adult', 'Alanine Transaminase', 'Aspartate Aminotransferases', 'Chronic Disease', 'Double-Blind Method', 'Female', 'Hepatitis C', 'Humans', 'Interferon alpha-2', 'Interferon-alpha', 'Male', 'Middle Aged', 'Recombinant Proteins'] | 2,127,786 | [['M01.060.116'], ['D08.811.913.477.700.100'], ['D08.811.913.477.700.225'], ['C23.550.291.500'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['C01.221.250.750', 'C01.925.440.440', 'C01.925.782.350.350', 'C06.552.380.705.440'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Characterization of the prothrombin gene expression during nerve differentiation. | The transcriptional regulation of the prothrombin gene expression in neuroblastomas was investigated because of the interest in non-hepatic thrombin expression and function in the nervous system. The data indicated that the murine prothrombin gene was distinctively transcribed in proliferating murine N2a cells and that... | ['Base Sequence', 'Blotting, Western', 'Bucladesine', 'Cell Differentiation', 'DNA', 'Electrophoretic Mobility Shift Assay', 'Gene Expression Regulation', 'Nervous System', 'Promoter Regions, Genetic', 'Prothrombin', 'RNA, Messenger', 'Reverse Transcriptase Polymerase Chain Reaction', 'Sequence Homology, Nucleic Acid'] | 15,245,911 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['D03.633.100.759.646.138.395.250', 'D13.695.462.200.250', 'D13.695.667.138.395.250', 'D13.695.827.068.395.250'], ['G04.152'], ['D13.444.308'], ['E05.196.401.5... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Ultrasound-assisted hydrolysis of conjugated parabens in human urine and their determination by UPLC-MS/MS and UPLC-HRMS. | Parabens are preservatives widely used in personal care products, pharmaceutical formulations as well as in food, and they are considered endocrine disruptors. For application in biomonitoring studies we developed a method for the determination of eight parabens from human urine. Sample preparation was enhanced and sim... | ['Adult', 'Chromatography, High Pressure Liquid', 'Chromatography, Liquid', 'Female', 'Humans', 'Hydrolysis', 'Limit of Detection', 'Male', 'Middle Aged', 'Parabens', 'Preservatives, Pharmaceutical', 'Tandem Mass Spectrometry', 'Ultrasonics', 'Urinalysis', 'Young Adult'] | 26,753,983 | [['M01.060.116'], ['E05.196.181.400.300'], ['E05.196.181.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.380'], ['E05.318.740.872.374', 'N05.715.360.750.725.500', 'N06.850.520.830.872.500'], ['M01.060.116.630'], ['D02.241.223.100.300.460', 'D02.241.511.390.460', 'D02.455.426.559.389.127.281.460', 'D02.455... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Treatment of idiopathic hepatic lipidosis in cats: 11 cases (1986-1987). | Idiopathic hepatic lipidosis was diagnosed in 11 cats. Cats were treated by delivery of balanced nutrients supplemented with L-carnitine via a surgically placed gastrostomy tube. Feeding through the gastrostomy tube was initiated in the hospital and was continued at home in all cats. The mean duration of gastrostomy tu... | ['Animals', 'Carnitine', 'Cat Diseases', 'Cats', 'Enteral Nutrition', 'Female', 'Gastrostomy', 'Lipidoses', 'Liver Diseases', 'Male', 'Retrospective Studies'] | 2,506,162 | [['B01.050'], ['D02.092.877.883.099'], ['C22.180'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['E02.421.360', 'E02.642.500.360'], ['E04.210.496', 'E04.579.408'], ['C16.320.565.398.641', 'C18.452.584.687', 'C18.452.648.398.641'], ['C06.552'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Caveolin-1 haploinsufficiency leads to partial transformation of human breast epithelial cells. | BACKGROUND: Caveolin-1 (Cav-1), a principal component of caveolae membranes, may function as a tumor suppressor in several types of human cancer.MATERIALS AND METHODS: In this report, we employed a retrovirus-mediated poly-A gene trapping approach to inactivate expression of genes that may be involved in transformation... | ['Animals', 'Breast', 'Breast Neoplasms', 'Caveolin 1', 'Caveolins', 'Cell Line', 'Cell Transformation, Neoplastic', 'Epithelial Cells', 'Female', 'Gene Silencing', 'Humans', 'Mice', 'Mice, Nude', 'RNA, Messenger', 'Transcription, Genetic', 'Transplantation, Heterologous'] | 14,981,899 | [['B01.050'], ['A01.236'], ['C04.588.180', 'C17.800.090.500'], ['D12.644.360.024.264', 'D12.776.157.057.010', 'D12.776.476.024.280', 'D12.776.543.990.100.500', 'D12.776.744.287'], ['D12.776.543.990.100'], ['A11.251.210'], ['C04.697.098.500', 'C23.550.727.098.500'], ['A11.436'], ['G05.308.203.374'], ['B01.050.150.900.64... | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The effect of estradiol on the proliferation of rabbit aortic medial tissue culture cells induced by hyperlipemic serum. | The outgrowths of medial explants of thoracic aorta from New Zealand rabbits were used to study the influence of estrogen on cell proliferation. After 5-6 weeks of rapid growth in Basal Eagle Medium (BME) supplemented with 10% normal rabbit serum, such cultures reached a stationary phase during which they showed little... | ['Animals', 'Aorta, Thoracic', 'Blood Physiological Phenomena', 'Cell Division', 'Connective Tissue', 'Connective Tissue Cells', 'Culture Techniques', 'Depression, Chemical', 'Estradiol', 'Hyperlipidemias', 'Lipids', 'Macaca mulatta', 'Muscle, Smooth, Vascular', 'Rabbits'] | 6,641,919 | [['B01.050'], ['A07.015.114.056.372'], ['G09.188'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A10.165'], ['A11.329'], ['E05.481.500'], ['G07.690.773.750'], ['D04.210.500.365.415.248', 'D06.472.334.851.437.500'], ['C18.452.584.500.500'], ['D10'], ['B01.050.150.900.649.313.988.400.112.19... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Expression of TrkB receptors in developing visual cortex is not regulated by light. | 1. Neurotrophins are very good candidates which relate electrical activity to molecular changes in activity-dependent phenomena. They exert their action through binding to specific tyrosine-kinase receptors: Trk receptors. It is important to consider Trk distribution in order to understand better the role of neurotroph... | ['Animals', 'Brain-Derived Neurotrophic Factor', 'Darkness', 'Gene Expression Regulation, Developmental', 'In Vitro Techniques', 'Light', 'Mice', 'Rats', 'Receptor, trkB', 'Visual Cortex'] | 11,860,191 | [['B01.050'], ['D12.644.276.860.100', 'D12.776.467.860.100', 'D12.776.631.600.100', 'D23.529.850.100'], ['G01.590.540.233'], ['G05.308.310'], ['E05.481'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.150.900.649.313.992.635.505.700'... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
H19-derived miR-675 contributes to bladder cancer cell proliferation by regulating p53 activation. | Long noncoding RNA 19 (H19) has been shown to promote bladder cancer cell proliferation and metastasis. However, little is known about how miR-675, mature product of H19, contributes to bladder cancer cell proliferation. In this study, we first evaluated the expression of miR-675 in bladder cancer tissues by quantitati... | ['Actins', 'Adult', 'Aged', 'Apoptosis', 'Cell Cycle', 'Cell Line, Tumor', 'Cell Proliferation', 'Cyclin D1', 'Female', 'Gene Expression Regulation, Neoplastic', 'Humans', 'Male', 'MicroRNAs', 'Middle Aged', 'RNA, Long Noncoding', 'Real-Time Polymerase Chain Reaction', 'Tumor Suppressor Protein p53', 'Urinary Bladder N... | 26,198,047 | [['D05.750.078.730.250', 'D12.776.210.500.100', 'D12.776.220.525.255'], ['M01.060.116'], ['M01.060.116.100'], ['G04.146.954.035'], ['G04.144'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.161.750', 'G07.345.249.410.750'], ['D12.644.360.262.150.100', 'D12.776.167.218.150.100', 'D12.776.476.262.150.100', 'D12.776.624.6... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Minimum muscular fitness of urban Tswana children. | Two hundred and eighty-nine urban school children in Botswana were tested for their ability to perform tests of minimum muscular fitness. Performance was generally poor when compared with usual results obtained in developed countries. Arm strength was found to be low but not surprising when considered in terms of the l... | ['Botswana', 'Child', 'Developing Countries', 'Female', 'Health', 'Humans', 'Male', 'Muscles', 'Physical Education and Training', 'Physical Fitness', 'Urban Health'] | 3,995,691 | [['Z01.058.290.175.230'], ['M01.060.406'], ['I01.615.500.300'], ['N01.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.633', 'A10.690'], ['I02.233.543'], ['G11.427.685', 'I03.450.642.845.054.800', 'N01.400.545'], ['N01.400.548.875']] | ['Geographicals [Z]', 'Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Duration of lactation and incidence of the metabolic syndrome in women of reproductive age according to gestational diabetes mellitus status: a 20-Year prospective study in CARDIA (Coronary Artery Risk Development in Young Adults). | OBJECTIVE: The objective of the study was to prospectively assess the association between lactation duration and incidence of the metabolic syndrome among women of reproductive age.RESEARCH DESIGN AND METHODS: Participants were 1,399 women (39% black, aged 18-30 years) in the Coronary Artery Risk Development in Young A... | ['Adolescent', 'Adult', 'Analysis of Variance', 'Blood Glucose', 'Body Mass Index', 'Cohort Studies', 'Continental Population Groups', 'Coronary Disease', 'Diabetes, Gestational', 'Educational Status', 'Female', 'Follow-Up Studies', 'Humans', 'Incidence', 'Insulin', 'Lactation', 'Longitudinal Studies', 'Metabolic Syndr... | 19,959,762 | [['M01.060.057'], ['M01.060.116'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['D09.947.875.359.448.500'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['M01.686.508'],... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Adenoma of the non-pigmented ciliary epithelium: a rare intraocular tumor with unusual immunohistochemical findings. | A case of adenoma of the non-pigmented ciliary epithelium with smooth muscle differentiation is reported. This uncommon ocular tumor affected a 36-year-old woman, and had caused decreased visual acuity and a total cataract. Ultrasound biomicroscopy disclosed an associated persistent hyperplasic primary vitreous (PHPV).... | ['Adenoma', 'Adult', 'Biomarkers, Tumor', 'Cataract', 'Cataract Extraction', 'Cell Differentiation', 'Cell Proliferation', 'Ciliary Body', 'Diagnosis, Differential', 'Epithelial Cells', 'Female', 'Humans', 'Immunohistochemistry', 'Microscopy, Acoustic', 'Myocytes, Smooth Muscle', 'Treatment Outcome', 'Uveal Neoplasms'] | 19,346,082 | [['C04.557.470.035'], ['M01.060.116'], ['D23.101.140'], ['C11.510.245'], ['E04.540.825.249'], ['G04.152'], ['G04.161.750', 'G07.345.249.410.750'], ['A09.371.060.160', 'A09.371.894.280'], ['E01.171'], ['A11.436'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E0... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Colony density influences invasive and filamentous growth in Saccharomyces cerevisiae. | The effect of colony density on the dimorphic switch was determined in natural strains of Saccharomyces cerevisiae. In some strains invasiveness and pseudohyphal (PH) growth were highly sensitive to colony density; moreover, strains constitutively able to invade the substrate with PH formation positively influenced the... | ['Colony Count, Microbial', 'Culture Media', 'Gene Expression Regulation, Fungal', 'Hyphae', 'Saccharomyces cerevisiae', 'Saccharomyces cerevisiae Proteins'] | 17,571,793 | [['E01.370.225.875.220', 'E05.200.875.220'], ['D27.720.470.305', 'E07.206'], ['G05.308.330'], ['A19.687.400'], ['B01.300.107.795.785.800', 'B01.300.930.705.655'], ['D12.776.354.750']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Relation of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio with coronary artery disease severity in patients undergoing coronary angiography. | BACKGROUND: Atherosclerosis is a chronic systemic inflammatory disease. Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are systemic inflammatory markers that are correlated with poor cardiovascular outcomes.AIM: To explore the relation of NLR and PLR with severity of coronary artery disease... | ['Aged', 'Biomarkers', 'Blood Cell Count', 'Blood Platelets', 'Coronary Angiography', 'Coronary Artery Disease', 'Female', 'Humans', 'Inflammation', 'Lymphocytes', 'Male', 'Middle Aged', 'Neutrophils', 'Severity of Illness Index'] | 25,987,404 | [['M01.060.116.100'], ['D23.101'], ['E01.370.225.500.195.107', 'E01.370.225.625.107', 'E05.200.500.195.107', 'E05.200.625.107', 'E05.242.195.107', 'G04.140.107', 'G09.188.105'], ['A11.118.188', 'A15.145.229.188'], ['E01.370.350.130.625', 'E01.370.350.700.060.200', 'E01.370.370.050.200', 'E01.370.370.380.200'], ['C14.28... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Development and characterization of spray-dried porous nanoaggregates for pulmonary delivery of anti-tubercular drugs. | Tuberculosis, MTB or tubercle bacillus (TB) is a lethal, infectious disease mainly caused by various strains of mycobacteria, usually Mycobacterium tuberculosis. In this study, guar gum-based porous nanoaggregates were formulated by precipitation technique with two frontline antitubercular drugs, i.e. isoniazid and rif... | ['Animals', 'Antitubercular Agents', 'Chemistry, Pharmaceutical', 'Delayed-Action Preparations', 'Drug Carriers', 'Female', 'Galactans', 'Isoniazid', 'Lung', 'Male', 'Mannans', 'Mycobacterium tuberculosis', 'Nanoparticles', 'Plant Gums', 'Porosity', 'Rats', 'Rats, Wistar', 'Rifampin', 'Tuberculosis'] | 24,870,203 | [['B01.050'], ['D27.505.954.122.085.255'], ['H01.158.703.007', 'H01.181.466'], ['D26.255.210', 'E02.319.300.253'], ['D26.255.260', 'E02.319.300.380'], ['D09.698.360'], ['D02.442.436', 'D03.066.349.410', 'D03.383.725.394.582'], ['A04.411'], ['D09.698.550'], ['B03.510.024.962.500.702', 'B03.510.460.400.410.552.552.702'],... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Vitamin B6 metabolism in chronic alcohol abuse The effect of ethanol oxidation on hepatic pyridoxal 5'-phosphate metabolism. | Individuals with chronic alcohol abuse frequently exhibit lowered plasma levels of pyridoxal 5'-phosphate, the coenzyme form of vitamin B6. Because the liver is the primary source of this coenzyme in plasma and also the principal organ that oxidizes ethanol, the effect of ethanol on hepatic pyridoxal phosphate metaboli... | ['Acute Disease', 'Alcoholic Intoxication', 'Animals', 'Chronic Disease', 'Humans', 'In Vitro Techniques', 'Liver', 'Male', 'Perfusion', 'Pyrazoles', 'Pyridoxal Phosphate', 'Pyridoxine', 'Rats', 'Time Factors', 'Vitamin B 6 Deficiency'] | 1,168,205 | [['C23.550.291.125'], ['C25.775.100.175', 'F03.900.100.300'], ['B01.050'], ['C23.550.291.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.481'], ['A03.620'], ['E05.680'], ['D03.383.129.539'], ['D03.383.725.676.925.500.500', 'D08.211.740'], ['D03.383.725.676.925.875'], ['B01.050.150.900.649.313.992.635.505.... | ['Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Functional integrity of anterior pituitary cells separated by a density gradient. | Using a continuous Percoll density gradient, endocrine cells of the anterior pituitary were separated. The cells were obtained from adult female Sprague-Dawley rats which had been ovariectomized for 7 days. The gradient revealed two equally sized populations of cells with densities of about 1.02 and 1.09 g/ml. Ninety-t... | ['Animals', 'Castration', 'Cell Separation', 'Cells, Cultured', 'Centrifugation, Density Gradient', 'Female', 'Fluorescent Antibody Technique', 'Growth Hormone', 'Immunoenzyme Techniques', 'Luteinizing Hormone', 'Pituitary Gland, Anterior', 'Prolactin', 'Rats', 'Rats, Inbred Strains', 'Thyrotropin'] | 3,890,454 | [['B01.050'], ['E04.270.282', 'E04.950.165'], ['E01.370.225.500.363', 'E05.200.500.363', 'E05.242.363'], ['A11.251'], ['E05.181.724.336', 'E05.196.941.336'], ['E01.370.225.500.607.512.240', 'E01.370.225.750.551.512.240', 'E05.200.500.607.512.240', 'E05.200.750.551.512.240', 'E05.478.583.375'], ['D06.472.699.631.525.425... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A simple procedure for the analysis of single nucleotide polymorphisms facilitates map-based cloning in Arabidopsis. | We developed a modified allele-specific PCR procedure for assaying single nucleotide polymorphisms (SNPs) and used the procedure (called SNAP for single-nucleotide amplified polymorphisms) to generate 62 Arabidopsis mapping markers. SNAP primers contain a single base pair mismatch within three nucleotides from the 3' e... | ['Alleles', 'Arabidopsis', 'Chromosome Mapping', 'Cloning, Molecular', 'DNA Primers', 'DNA, Plant', 'Genetic Markers', 'Mutation', 'Polymerase Chain Reaction', 'Polymorphism, Single Nucleotide'] | 11,115,864 | [['G05.360.340.024.340.030'], ['B01.650.940.800.575.912.250.157.100'], ['E05.393.183'], ['E05.393.220'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['D13.444.308.435'], ['D23.101.387', 'G05.695.450'], ['G05.365.590'], ['E05.393.620.500'], ['G05.365.795.598']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Behaviour of beta-lactamase-positive and -negative Staphylococcus aureus isolates in susceptibility tests with piperacillin/tazobactam and other beta-lactam/beta-lactamase inhibitor combinations. | beta-Lactamase production protects Staphylococcus aureus against piperacillin and amoxycillin. Tazobactam and clavulanate inhibit the enzyme, but beta-lactamase producers remained substantially less susceptible than non-producers to piperacillin/tazobactam and co-amoxiclav in disc tests. These observations reflected th... | ['Anti-Bacterial Agents', 'Drug Synergism', 'Drug Therapy, Combination', 'Enzyme Induction', 'Indicators and Reagents', 'Microbial Sensitivity Tests', 'Penicillanic Acid', 'Penicillin Resistance', 'Piperacillin', 'Staphylococcus aureus', 'Tazobactam', 'beta-Lactamase Inhibitors', 'beta-Lactamases'] | 8,262,865 | [['D27.505.954.122.085'], ['G07.690.773.968.477'], ['E02.319.310'], ['G05.308.320.200'], ['D27.720.470.410'], ['E01.370.225.875.595', 'E05.200.875.595', 'E05.337.550.400'], ['D02.065.589.099.750.687', 'D02.886.108.750.687', 'D03.633.100.300.750.687'], ['G06.099.225.500.600', 'G06.225.347.500.600', 'G07.690.773.984.269.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Transcriptional regulation of cellular retinaldehyde-binding protein in the retinal pigment epithelium. A role for the photoreceptor consensus element. | Cellular retinaldehyde-binding protein (CRALBP) is abundantly expressed in the retinal pigment epithelium (RPE) and Muller cells of the retina, where it is thought to function in retinoid metabolism and visual pigment regeneration. Mutations in human CRALBP that destroy retinoid binding have been linked to autosomal re... | ['Carrier Proteins', 'Cells, Cultured', 'Consensus Sequence', 'DNA-Binding Proteins', 'Gene Expression Regulation', 'Genes, Reporter', 'Humans', 'Mutagenesis, Site-Directed', 'Nuclear Proteins', 'Oligodeoxyribonucleotides', 'Pigment Epithelium of Eye', 'Promoter Regions, Genetic', 'Retinaldehyde', 'Retinitis Pigmentosa... | 9,488,687 | [['D12.776.157'], ['A11.251'], ['G02.111.570.580.175'], ['D12.776.260'], ['G05.308'], ['G05.360.340.024.340.435'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.393.420.601.575'], ['D12.776.660'], ['D13.695.578.424.450'], ['A09.371.670', 'A10.272.640'], ['G02.111.570.080.689.675', 'G05.360.080.689.675', 'G05.3... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Generation of Triple-Transgenic Forsythia Cell Cultures as a Platform for the Efficient, Stable, and Sustainable Production of Lignans. | Sesamin is a furofuran lignan biosynthesized from the precursor lignan pinoresinol specifically in sesame seeds. This lignan is shown to exhibit anti-hypertensive activity, protect the liver from damages by ethanol and lipid oxidation, and reduce lung tumor growth. Despite rapidly elevating demand, plant sources of lig... | ['Cell Culture Techniques', 'Cells, Cultured', 'Forsythia', 'Lignans', 'Molecular Structure', 'Plant Proteins', 'Plants, Genetically Modified', 'RNA, Small Interfering'] | 26,641,084 | [['E01.370.225.500.223', 'E05.200.500.265', 'E05.242.223', 'E05.481.500.249'], ['A11.251'], ['B01.650.940.800.575.912.250.583.640.333'], ['D02.455.426.559.389.140.450'], ['G02.111.570', 'G02.466'], ['D12.776.765'], ['B01.650.520', 'B05.620.600'], ['D13.150.650.700', 'D13.444.735.150.700', 'D13.444.735.790.552.875']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The role of miR-24 as a race related genetic factor in prostate cancer. | The incidence of prostate cancer (PCa) among African-Americans (AfA) is significantly higher than Caucasian-Americans (CaA) but the genetic basis for this disparity is not known. To address this problem, we analyzed miRNA expression in AfA (n = 81) and CaA (n = 51) PCa patients. Here, we found that miR-24 is differenti... | ['Apoptosis', 'Cell Line, Tumor', 'Cell Proliferation', 'Down-Regulation', 'Humans', 'Incidence', 'Male', 'MicroRNAs', 'Prostatic Neoplasms'] | 28,157,714 | [['G04.146.954.035'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.161.750', 'G07.345.249.410.750'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.985.525.375'], ['D1... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Medial trigonal arteriovenous malformations. | A retrospective analysis of 48 patients of medial paratrigonal arteriovenous malformations (AVMs) which constituted 18% of the total 258. AVMs surgically managed in our institute for 16 years was carried out to study their clinical presentation, radiological features, operative approaches and functional outcome. While ... | ['Adolescent', 'Adult', 'Cerebral Ventricles', 'Child', 'Child, Preschool', 'Female', 'Humans', 'Intracranial Arteriovenous Malformations', 'Male', 'Middle Aged', 'Postoperative Complications', 'Prognosis', 'Radiography', 'Retrospective Studies'] | 10,750,376 | [['M01.060.057'], ['M01.060.116'], ['A08.186.211.140'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.228.140.300.520', 'C10.500.190.500', 'C14.240.850.750.295', 'C14.240.850.875.500', 'C14.907.150.295', 'C14.907.253.560.400', 'C16.131.240.850.750.295', 'C16.131.240.850.87... | ['Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Statistical mechanics and the evolution of polygenic quantitative traits. | The evolution of quantitative characters depends on the frequencies of the alleles involved, yet these frequencies cannot usually be measured. Previous groups have proposed an approximation to the dynamics of quantitative traits, based on an analogy with statistical mechanics. We present a modified version of that appr... | ['Entropy', 'Evolution, Molecular', 'Genetic Variation', 'Models, Genetic', 'Multifactorial Inheritance', 'Mutation', 'Selection, Genetic'] | 19,087,953 | [['G01.906.345'], ['G05.045.250', 'G16.075.250'], ['G05.365'], ['E05.599.395.397'], ['G05.420.590'], ['G05.365.590'], ['G05.783']] | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
CEACAM 6, a novel marker for the diagnosis of Barrett's esophagus. | Barrett's esophagus (BE) is a premalignant condition associated with the development of esophageal adenocarcinoma (EAC). Despite the low risk of progression to EAC, evidence highlights the notably poor survival rates of this malignancy. The mainstay form of diagnosis of BE is endoscopy and biopsy sampling. However, res... | ['Adenocarcinoma', 'Aged', 'Antigens, CD', 'Barrett Esophagus', 'Biomarkers', 'Biopsy', 'Cell Adhesion Molecules', 'Esophageal Neoplasms', 'Esophagus', 'Female', 'GPI-Linked Proteins', 'Humans', 'Male', 'Middle Aged', 'ROC Curve', 'Retrospective Studies'] | 28,475,729 | [['C04.557.470.200.025'], ['M01.060.116.100'], ['D23.050.301.264.035', 'D23.101.100.110'], ['C04.834.154', 'C06.405.117.102'], ['D23.101'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['D12.776.395.550.200', 'D12.776.543.... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Usefulness of High-Quality Core Genome Single-Nucleotide Variant Analysis for Subtyping the Highly Clonal and the Most Prevalent Salmonella enterica Serovar Heidelberg Clone in the Context of Outbreak Investigations. | Salmonella enterica serovar Heidelberg is the second most frequently occurring serovar in Quebec and the third-most prevalent in Canada. Given that conventional pulsed-field gel electrophoresis (PFGE) subtyping for common Salmonella serovars, such as S. Heidelberg, yields identical subtypes for the majority of isolates... | ['Disease Outbreaks', 'Electrophoresis, Gel, Pulsed-Field', 'Genome, Bacterial', 'Genomics', 'Genotype', 'High-Throughput Nucleotide Sequencing', 'Humans', 'Molecular Typing', 'Polymorphism, Single Nucleotide', 'Quebec', 'Salmonella Infections', 'Salmonella enterica'] | 26,582,830 | [['N06.850.290'], ['E05.196.401.220', 'E05.301.300.220'], ['G05.360.340.358.207'], ['H01.158.273.180.350', 'H01.158.273.343.350'], ['G05.380'], ['E05.393.760.319'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.875.150.125.457', 'E05.200.875.150.125.457', 'E05.393.542'], ['G05.365.795.598'], ['Z01.107.... | ['Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Geographicals [Z]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
Low-temperature synthesis of hierarchical structures of copper oxide and their superior biological activity. | In this work, the authors report a facile low-temperature wet-chemical route to prepare morphology-tailored hierarchical structures (HS) of copper oxide. The preparation of copper oxide collides was carried out using varying concentrations of copper acetate and a reducing agent at a constant temperature of 50°C. The pr... | ['Anti-Bacterial Agents', 'Antifungal Agents', 'Bacteria', 'Copper', 'Fungi', 'Hydrogen Peroxide', 'Metal Nanoparticles', 'Protein Kinases', 'Temperature', 'X-Ray Diffraction'] | 30,247,139 | [['D27.505.954.122.085'], ['D27.505.954.122.136'], ['B03'], ['D01.268.556.195', 'D01.268.956.170', 'D01.552.544.195'], ['B01.300'], ['D01.248.497.158.685.750.424', 'D01.339.431.374.424', 'D01.650.550.750.400', 'D02.389.338.253'], ['J01.637.512.600.500'], ['D08.811.913.696.620.682'], ['G01.906.595', 'G16.500.275.063.725... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
[Pelviscopy: a good solution]. | With the ongoing evaluation of laparoscopic techniques in urology, the transperitoneal access used initially has been progressively replaced by the much simpler retroperitoneal route. The applicability of these new techniques has now been proven though their application still requires a delicate procedure. A long train... | ['Endoscopy', 'Female', 'Humans', 'Lymph Node Excision', 'Nephrectomy', 'Pelvis'] | 8,945,830 | [['E01.370.388.250', 'E04.502.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.446'], ['E04.950.774.435'], ['A01.923.600']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The role of cough and hyperventilation in perpetuating airway inflammation in asthma. | Air flowing through a pipe exerts frictional stress on the walls of the pipe. Frictional stress of more than 40 N/m2 (velocity equivalent of air 113 m/s) is known to cause acute endothelial damage in blood vessels. The frictional stress in airways during coughing may be much greater, however, since the velocity of air ... | ['Asthma', 'Biomechanical Phenomena', 'Bronchi', 'Cough', 'Humans', 'Hyperventilation', 'Inflammation', 'Pulmonary Ventilation', 'Trachea'] | 11,229,124 | [['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['G01.154.090', 'G01.374.089'], ['A04.411.125'], ['C08.618.248', 'C23.888.852.293'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C08.618.501', 'C23.888.852.591'], ['C23.550.470'], ['E01.370.386.700.660', 'G09.772.650'], ['A04.889']] | ['Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The Critical Role of Supply Chains in Preventing Human Immunodeficiency Virus Drug Resistance in Low- and Middle-Income Settings. | The functioning of the supply chain may be a driving factor behind the development of human immunodeficiency virus (HIV) drug resistance (HIVDR) in many low- and middle-income countries (LMICs). Additionally, the effectiveness of supply chains will likely impact the scale-up of both viral-load monitoring and HIVDR test... | ['Anti-HIV Agents', 'Developing Countries', 'Drug Resistance, Viral', 'HIV', 'HIV Infections', 'Humans', 'International Cooperation', 'Viral Load'] | 29,029,317 | [['D27.505.954.122.388.077.088'], ['I01.615.500.300'], ['G06.225.420', 'G06.920.225', 'G07.690.773.984.269.420'], ['B04.820.650.589.650.350'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I0... | ['Chemicals and Drugs [D]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
Seasonal variation of serum vitamin D among Greek female patients with osteoporosis. | BACKGROUND/AIM: Vitamin D (vitD) levels are positively associated with bone health and seasonality affects serum vit D. The aim of the study was to investigate the degree of seasonal variation on 25-hydroxyvitamin D (25(OH)D) serum levels in a population-based cohort of post-menopausal women with osteoporosis.PATIENTS ... | ['Aged', 'Aged, 80 and over', 'Female', 'Humans', 'Middle Aged', 'Osteoporosis', 'Prevalence', 'Seasons', 'Vitamin D'] | 25,977,390 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C05.116.198.579', 'C18.452.104.579'], ['E05.318.308.985.525.750', 'N01.224.935.597.750', 'N06.850.505.400.975.525.750', 'N06.850.520.308.985.525.750'], ['G01.910.645.661', 'G16.500.275.071.590', 'N06.2... | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Sarcoballs: direct access to sarcoplasmic reticulum Ca2+-channels in skinned frog muscle fibers. | In skeletal muscle, twitch contraction is caused by the rapid release of Ca2+ from the sarcoplasmic reticulum (SR) (Endo, M. 1977. Physiol. Rev. 57:71-108) via Ca2+ conducting channels in the SR membrane (Smith, J. S., R. Coronado, and G. Meissner, 1985. Nature (Lond.). 316:446-449; Suarez-Isla, B. A., G. Orozco, P. F.... | ['Animals', 'Calcium', 'Electric Conductivity', 'In Vitro Techniques', 'Ion Channels', 'Membrane Potentials', 'Microscopy, Electron', 'Muscles', 'Rana catesbeiana', 'Sarcoplasmic Reticulum'] | 2,462,926 | [['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['G01.358.500.249.277'], ['E05.481'], ['D12.776.157.530.400', 'D12.776.543.550.450', 'D12.776.543.585.400'], ['G01.154.535', 'G04.580', 'G07.265.675', 'G11.561.570'], ['E01.370.350.515.402', 'E05.595.402'], ['A02.633', 'A10.690'], ['B01.050.150.900.09... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Real-time and high throughput monitoring of cAMP in live cells using a fluorescent membrane potential-sensitive dye. | Adenosine-3',5'-cyclic monophosphate (cAMP) conveys the signals from G-protein coupled receptors (GPCRs) and regulates a variety of downstream cellular events. However, there are few robust assays available for measuring cAMP in live cells. Most of the existing cAMP assays require cell lysis and/or have relatively low ... | ['3T3 Cells', "Adenosine-5'-(N-ethylcarboxamide)", 'Animals', 'Barbiturates', 'Biosensing Techniques', 'Cell Line', 'Cyclic AMP', 'Cyclic Nucleotide-Gated Cation Channels', 'Cytoplasm', 'Dose-Response Relationship, Drug', 'Fluorescence', 'Fluorescent Dyes', 'Humans', 'Ion Channels', 'Isoxazoles', 'Kinetics', 'Membrane ... | 16,945,018 | [['A11.251.210.100', 'A11.329.228.100'], ['D03.633.100.759.590.138.025', 'D13.570.583.138.025', 'D13.570.800.096.250'], ['B01.050'], ['D03.383.742.698.253'], ['E05.601.043'], ['A11.251.210'], ['D03.633.100.759.646.138.395', 'D13.695.462.200', 'D13.695.667.138.395', 'D13.695.827.068.395'], ['D12.776.157.530.400.337', 'D... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Study on efficacy of Chinese Kidney-Tonifying Recipe in male rats with osteoporosis induced by dexamethasone and its mechanism]. | OBJECTIVE: To study the efficacy of traditional Chinese Kidney-Tonifying Recipe (KTR) in male rats with osteoporosis induced by dexamethasone (DM) and its mechanism.METHODS: Forty-six male Sprague-Dawley rats at 12 months of age were chosen: they were divided into four groups and KTR and DM were administered appropriat... | ['Animals', 'Bone Density', 'Dexamethasone', 'Drugs, Chinese Herbal', 'Male', 'Osteoporosis', 'Parathyroid Hormone', 'Random Allocation', 'Rats', 'Rats, Sprague-Dawley', 'Testosterone'] | 11,477,928 | [['B01.050'], ['G11.427.100'], ['D04.210.500.745.432.769.344', 'D04.210.500.908.238'], ['D20.215.784.500.350', 'D26.335'], ['C05.116.198.579', 'C18.452.104.579'], ['D06.472.699.590', 'D12.644.548.587'], ['E05.318.370.700', 'E05.581.500.805', 'N05.715.360.325.675', 'N06.850.520.445.700'], ['B01.050.150.900.649.313.992.6... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
The cell types in the adenohypophysis of the South-American lungfish, Lepidosiren paradoxa, with special reference to immunocytochemical identification of the corticotropin-containing cells. | The histological features and distribution of cell types in the distal lobe of Lepidosiren resemble those of Protopterus. Three "basophilic" cell types are described, whereas the identification of two acidophilic cell types is uncertain. In the intermediate lobe two cell types have been found. Anti-(1-24)ACTH IgG was u... | ['Adrenocorticotropic Hormone', 'Animals', 'Fishes', 'Histocytochemistry', 'Immunologic Techniques', 'Melanocyte-Stimulating Hormones', 'Microscopy, Electron', 'Pituitary Gland', 'Radioimmunoassay'] | 6,253,074 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Tibial Fixation Properties of a Continuous-Loop ACL Hamstring Graft Construct with Suspensory Fixation in Porcine Bone. | The aim of this article is to compare tibial fixation strength of suspensory fixation for a quadrupled semitendinosus continuous loop all-inside anterior cruciate ligament (ACL) construct versus a doubled semitendinosus and gracilis graft fixated with an interference screw. Biomechanical testing was conducted using hum... | ['Animals', 'Anterior Cruciate Ligament', 'Anterior Cruciate Ligament Reconstruction', 'Biomechanical Phenomena', 'Bone Screws', 'Disease Models, Animal', 'Suture Anchors', 'Suture Techniques', 'Swine', 'Tibia', 'Transplantation, Homologous', 'Transplants'] | 25,347,056 | [['B01.050'], ['A02.513.514.100', 'A02.835.583.512.100', 'A10.165.669.514.100'], ['E04.555.110.026', 'E04.680.101.026'], ['G01.154.090', 'G01.374.089'], ['E07.695.370.437', 'E07.858.442.660.460.437', 'E07.858.690.725.460.437'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['E07.695.370.734', 'E07.858.442.660.460.734'... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Central corneal thickness and intraocular tension in patients with acromegaly. | In 27 patients with pituitary adenomas the central corneal thickness and the intraocular tension were measured. Thirteen of the patients were suffering from acromegaly, and in this group the central corneal thickness was 0.561 mm +/- 0.35 (mean +/- SD). In the 14 patients with pituitary adenomas but no acromegaly the c... | ['Acromegaly', 'Adenoma, Acidophil', 'Adult', 'Aged', 'Cornea', 'Female', 'Glaucoma', 'Humans', 'Intraocular Pressure', 'Male', 'Middle Aged', 'Pituitary Neoplasms'] | 6,277,144 | [['C05.116.132.082', 'C10.228.140.617.738.250.100', 'C19.700.355.179'], ['C04.557.465.625.650.025', 'C04.557.470.035.025', 'C04.557.580.625.650.025'], ['M01.060.116'], ['M01.060.116.100'], ['A09.371.060.217'], ['C11.525.381'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G14.440'], ['M01.060.116.630'], ['C04.588.... | ['Diseases [C]', 'Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Factors influencing mortality in patients on antiplatelet agents presenting with proximal femoral fractures. | PURPOSE: To identify factors predicting one-year mortality in patients on clopidogrel presenting with proximal femoral fractures.METHODS: 9 men and 22 women aged 64 to 97 (mean, 81; standard deviation, 8) years who had been taking clopidogrel for ischaemic heart disease (n=15), cerebrovascular disease (n=6), or both (n... | ['Aged', 'Aged, 80 and over', 'Arthroplasty, Replacement, Hip', 'Cerebrovascular Disorders', 'Clopidogrel', 'Comorbidity', 'Femoral Neck Fractures', 'Fracture Fixation, Internal', 'Hip Fractures', 'Humans', 'Kaplan-Meier Estimate', 'Male', 'Middle Aged', 'Myocardial Ischemia', 'Platelet Aggregation Inhibitors', 'Ticlop... | 22,184,161 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['E04.555.110.110.110', 'E04.650.110.110', 'E04.680.101.110.110'], ['C10.228.140.300', 'C14.907.253'], ['D02.886.778.823.500.500', 'D03.383.725.849.500.500', 'D03.383.903.830.500.500', 'D03.633.100.928.500.500'], ['N05.715.350.225', 'N06.850.490.687'], ['C26.404.061.425.50... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Fatality from disseminated intravascular coagulation complicating total hip arthroplasty: a case report. | Following a routine hybrid total hip arthroplasty in an eighty-two year-old female, profuse bleeding occurred through the suction drain immediately postoperatively. The patient was found to have acute disseminated intravascular coagulation. Despite early recognition and treatment the patient died fourteen days later. | ['Acute Disease', 'Aged', 'Aged, 80 and over', 'Disseminated Intravascular Coagulation', 'Erythrocyte Transfusion', 'Fatal Outcome', 'Female', 'Hematocrit', 'Hip Prosthesis', 'Humans', 'Osteoarthritis, Hip', 'Platelet Transfusion'] | 9,234,974 | [['C23.550.291.125'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C15.378.100.220', 'C15.378.463.250', 'C15.378.925.220'], ['E02.095.135.140.275'], ['E05.318.308.985.550.325', 'N01.224.935.698.201', 'N06.850.505.400.975.550.325', 'N06.850.520.308.985.550.325'], ['E01.370.225.625.400', 'E05.200.625.400', 'G09.188.37... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Phosphorylation-dependent monoclonal Tau antibodies do not reliably report phosphorylation by extracellular signal-regulated kinase 2 at specific sites. | Analysis of phosphorylation of tau, the microtubule-associated proteins hyperphosphorylated in Alzheimer's disease, is often performed using phosphorylation-sensitive monoclonal antibodies thought to report the presence or absence of one or two specific phosphorylations (cognate sites). Using several such antibodies we... | ['Antibodies, Monoclonal', 'Binding Sites', 'Calcium-Calmodulin-Dependent Protein Kinases', 'Electrophoresis, Gel, Two-Dimensional', 'Humans', 'Mitogen-Activated Protein Kinase 1', 'Peptide Mapping', 'Phosphorus Radioisotopes', 'Phosphorylation', 'Recombinant Proteins', 'tau Proteins'] | 9,020,176 | [['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['G02.111.570.120'], ['D08.811.913.696.620.682.700.125', 'D12.644.360.100', 'D12.776.476.100'], ['E05.196.401.250', 'E05.301.300.230'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.913.696.620.682.700.567.249.5... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Larval development of the tropical deep-sea echinoid Aspidodiadema jacobyi: phylogenetic implications. | The complete larval development of an echinoid in the family Aspidodiadematidae is described for the first time from in vitro cultures of Aspidodiadema jacobyi, a bathyal species from the Bahamian Slope. Over a period of 5 months, embryos grew from small (98-micron) eggs to very large (3071-micron) and complex planktot... | ['Animals', 'Invertebrates', 'Larva', 'Marine Biology', 'Phylogeny'] | 10,897,452 | [['B01.050'], ['B01.050.500'], ['B05.500.500', 'G07.345.500.550.500.500'], ['H01.158.273.248.750.500', 'H01.277.249.750.500', 'H01.277.750.500'], ['G05.697', 'G16.075.605', 'L01.100.697']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Neurotensin enhances endogenous extracellular glutamate levels in primary cultures of rat cortical neurons: involvement of neurotensin receptor in NMDA induced excitotoxicity. | Primary cultures of cortical neurons were employed to investigate the modulatory effects of neurotensin on glutamate excitotoxicity and the possible neuroprotective actions of the neurotensin receptor antagonist SR48692. NT(1-13) and its biologically active fragment NT(8-13) at 10 nM (30 min) increased endogenous gluta... | ['Animals', 'Bisbenzimidazole', 'Calcium', 'Cells, Cultured', 'Cerebral Cortex', 'Chromatin', 'Coloring Agents', 'Enzyme Inhibitors', 'Excitatory Amino Acid Agonists', 'Extracellular Space', 'Glutamic Acid', 'N-Methylaspartate', 'Naphthalenes', 'Neurons', 'Neurotensin', 'Neurotoxicity Syndromes', 'Peptide Fragments', '... | 15,028,650 | [['B01.050'], ['D03.633.100.103.145'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['A11.251'], ['A08.186.211.200.885.287.500'], ['A11.284.430.106.279.345.190.160.180', 'D12.776.664.224', 'G05.360.160.180'], ['D27.720.233'], ['D27.505.519.389'], ['D27.505.519.625.190.200', 'D27.505.696.577.190.200'], ['A10.0... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The Need for a Vena Cava Filter in Oncological Patients with Acute Venous Thrombosis: A Marker of a Worse Prognosis. | BACKGROUND: Active cancer is found in approximately 20% of patients diagnosed with venous thromboembolism. This condition is more prevalent in patients with advanced and metastatic cancer and is the second largest cause of death among patients with active neoplasm. Many of them have contraindication for anticoagulation... | ['Acute Disease', 'Adult', 'Aged', 'Aged, 80 and over', 'Anticoagulants', 'Cause of Death', 'Contraindications, Drug', 'Electronic Health Records', 'Female', 'Humans', 'Male', 'Middle Aged', 'Neoplasms', 'Retrospective Studies', 'Risk Assessment', 'Risk Factors', 'Time Factors', 'Treatment Outcome', 'Vena Cava Filters'... | 30,802,572 | [['C23.550.291.125'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.954.502.119'], ['E05.318.308.985.550.250', 'N01.224.935.698.100', 'N06.850.505.400.975.550.250', 'N06.850.520.308.985.550.250'], ['E02.208.200'], ['E05.318.308.940.968.625.500', 'N04.452.859.564.650.125', 'N05.715.360.300.715... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Spontaneous hemothorax revealing Wegener's vasculitis in a pregnant woman]. | Spontaneous hemothorax is a rare condition. Its causes are multiple but sometimes they remain unknown. In some patients, thoracotomy may be the only means to determine hemothorax origin. Vasculitis have not been reported as a common cause of spontaneous hemothorax. Pregnancy does not appear to have causal or aggravatin... | ['Adolescent', 'Biopsy', 'Female', 'Granulomatosis with Polyangiitis', 'Hemothorax', 'Humans', 'Pregnancy', 'Pregnancy Complications, Cardiovascular', 'Thoracotomy'] | 28,154,726 | [['M01.060.057'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['C08.381.483.950', 'C14.907.940.897.249.750', 'C20.111.193.875'], ['C08.528.380', 'C23.550.414.904'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G08.6... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Wash effect of atmospheric trace metals wet deposition and its source characteristic in subtropical watershed in China. | In order to better understand air pollution in deve-loping regions, such as China, it is important to investigate the wet deposition behavior of atmospheric trace metals and its sources in the subtropical watershed. This paper studies the seasonal change of trace metal concentrations in precipitation and other potentia... | ['Aerosols', 'Air Pollutants', 'China', 'Environmental Monitoring', 'Metals', 'Seasons', 'Trace Elements', 'Water Pollutants, Chemical', 'Water Pollution, Chemical'] | 27,457,553 | [['D20.280.055', 'D26.255.165.055'], ['D27.888.284.101'], ['Z01.252.474.164'], ['N06.850.460.350.080', 'N06.850.780.375'], ['D01.552'], ['G01.910.645.661', 'G16.500.275.071.590', 'N06.230.300.100.250.525'], ['D01.268.811', 'D27.505.696.494.555', 'G07.203.300.681.500.555', 'J02.500.681.500.555'], ['D27.888.284.903.655']... | ['Chemicals and Drugs [D]', 'Geographicals [Z]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
Ovum donation. | Recent advances in assisted conception and reproductive endocrinology have provided novel avenues for the treatment of couples previously thought to be irreversibly sterile. | ['Estrogens', 'Ethics, Medical', 'Female', 'Gamete Intrafallopian Transfer', 'Humans', 'Infertility, Female', 'Ovarian Diseases', 'Ovum', 'Pregnancy', 'Pregnancy Outcome', 'Progesterone', 'Tissue Donors'] | 2,611,471 | [['D27.505.696.399.472.277'], ['K01.752.566.479.171.132.750', 'N05.350.340.162.500'], ['E02.875.800.875', 'E05.820.800.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C13.351.500.365.700'], ['C13.351.500.056.630', 'C19.391.630'], ['A05.360.490.690', 'A11.497.497', 'A16.690'], ['G08.686.784.769'], ['E01.789.70... | ['Chemicals and Drugs [D]', 'Humanities [K]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Named Groups [M]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Extent of thyroidectomy and lymphadenectomy in 254 patients with papillary thyroid microcarcinoma: a single-institution experience. | BACKGROUND: No agreement has been made about the optimal extent of thyroidectomy or lymph node dissection in papillary thyroid microcarcinoma (PTMC). Our aim was to find out the factors associated with the presence of lymph node metastases in the patients with PTMC and to discuss the extent of thyroidectomy and lymphad... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Carcinoma, Papillary', 'Female', 'Humans', 'Lymph Node Excision', 'Male', 'Middle Aged', 'Thyroid Neoplasms', 'Thyroidectomy', 'Young Adult'] | 19,189,188 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C04.557.470.200.360', 'C04.557.470.700.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.446'], ['M01.060.116.630'], ['C04.588.322.894', 'C04.588.443.915', 'C19.344.894', 'C19.874.788'], ['E04.270.856'], ['M01.060.116.815']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
CT guided percutaneous fine needle biopsy in the diagnosis of small adrenal tumours. | In the diagnosis of expansive lesions of the pancreas, liver, kidneys, lymph nodes and other organs, percutaneous fine needle aspiration biopsy has proved its value. For small objects computed tomography is particularly suitable as a localization aid. This article reports on the diagnostic advantages of CT and biopsy i... | ['Adenoma', 'Adrenal Gland Neoplasms', 'Aged', 'Biopsy, Needle', 'Evaluation Studies as Topic', 'Humans', 'Middle Aged', 'Phlebography', 'Punctures', 'Tomography, X-Ray Computed'] | 6,653,573 | [['C04.557.470.035'], ['C04.588.322.078', 'C19.053.347', 'C19.344.078'], ['M01.060.116.100'], ['E01.370.225.500.384.100.119', 'E01.370.225.998.054.119', 'E01.370.388.100.100', 'E04.074.119', 'E04.665.100', 'E05.200.500.384.100.119', 'E05.200.998.054.119', 'E05.242.384.100.119'], ['E05.337', 'N05.715.360.335'], ['B01.05... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Cycloxygenase-2 inhibition augments the efficacy of a cancer vaccine. | Tumor-derived cyclooxygenase-2 (COX-2) and its product, prostaglandin E2, exert strong immunoinhibitory effects that block dendritic cell function and CD4+ and CD8+ T-cell proliferation and function. We have shown previously that the addition of an oral COX-2 inhibitor to immunogene therapy using IFN-beta markedly augm... | ['Administration, Oral', 'Animals', 'CD8-Positive T-Lymphocytes', 'Cancer Vaccines', 'Chemokines', 'Cyclooxygenase 2 Inhibitors', 'Flow Cytometry', 'Humans', 'Lactones', 'Mice', 'Neoplasms, Experimental', 'Oncogene Proteins, Viral', 'Papillomaviridae', 'Reverse Transcriptase Polymerase Chain Reaction', 'Sulfones'] | 16,397,045 | [['E02.319.267.100'], ['B01.050'], ['A11.118.637.555.567.569.220', 'A15.145.229.637.555.567.569.220', 'A15.382.490.555.567.569.220'], ['D20.215.894.200'], ['D12.644.276.374.200', 'D12.776.467.374.200', 'D23.125.300', 'D23.469.200', 'D23.529.374.200'], ['D27.505.519.389.310.500', 'D27.505.696.663.850.014.040.500.500.500... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Retinal growth in double dorsal and double ventral eyes in Xenopus. | The growth of normal and surgically produced compound dorsal and ventral retinae in Xenopus laevis has been studied autoradiographically following injections of [3H] thymidine at stages 50 and 58. The animals were sacrificed 3 weeks after metamorphosis. The histogenetic pattern of the dorsal and ventral retinal halves ... | ['Animals', 'Cell Count', 'Metamorphosis, Biological', 'Neurons', 'Retina', 'Time Factors', 'Xenopus'] | 915,422 | [['B01.050'], ['E01.370.225.500.195', 'E05.200.500.195', 'E05.242.195', 'G04.140'], ['G07.345.500.550'], ['A08.675', 'A11.671'], ['A09.371.729'], ['G01.910.857'], ['B01.050.150.900.090.180.610.500']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A quality-control program for colposcopic practice. | Quality control is accepted as an integral part of the cytology laboratory's activities. However, provision of similar safeguards for colposcopic practice in assessing patients with abnormal cervical cytology has been an elusive problem. This report describes the quality-control program for colposcopy that is used prov... | ['Biopsy', 'British Columbia', 'Carcinoma', 'Colposcopy', 'Female', 'Humans', 'Laboratories, Hospital', 'Quality Control', 'Uterine Cervical Diseases', 'Uterine Cervical Neoplasms'] | 1,923,214 | [['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['Z01.107.567.176.160'], ['C04.557.470.200'], ['E01.370.378.150', 'E01.370.388.250.150', 'E04.502.250.150', 'E04.520.150', 'E04.950.300.210'], ['B01.050.150.900.649.313.988.400... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
A simple and convenient method for the simultaneous in vitro study of metformin and glimepiride tablets. | A simple and convenient method was developed for the simultaneous determination of metformin HCl and glimepiride in tablet dosage form of different pharmaceuticals companies. This method was validated and proved to be applicable for assay determination in intermediate and finished staged. More over a single medium diss... | ['Chromatography, High Pressure Liquid', 'Drug Combinations', 'Hypoglycemic Agents', 'Metformin', 'Solubility', 'Sulfonylurea Compounds', 'Tablets'] | 25,362,617 | [['E05.196.181.400.300'], ['D26.310'], ['D27.505.696.422'], ['D02.078.370.141.450'], ['G02.805'], ['D02.065.950.828', 'D02.886.590.795'], ['D26.255.830']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The 19th Century Origins of Facial Cosmetic Surgery and John H. Woodbury. | John H. Woodbury was an incredibly entrepreneurial, self-trained dermatologist who, between 1870 and 1909, built an empire of cosmetic surgery institutes in 6 states, with 25 physician/surgeon employees and an advertising budget of $150,000/year (1892 data). Under his management, his surgeons, and perhaps Woodbury hims... | ['Commerce', 'Cosmetic Techniques', 'History, 19th Century', 'Humans', 'Licensure, Medical', 'Surgery, Plastic', 'United States'] | 26,069,152 | [['J01.219'], ['E02.218'], ['K01.400.504.937'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.706.110.510.410', 'N05.700.200.450.500'], ['H02.403.810.788'], ['Z01.107.567.875']] | ['Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Humanities [K]', 'Organisms [B]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 |
Ambulance services move to a new payment method. | As payments for ambulance services undergo a transition away from a system based on reasonable costs, healthcare organizations need to establish billing practices in accordance with the fee schedule mandated by the Balanced Budget Act of 1997. Of particular interest is the development of a new coding system for ambulan... | ['Ambulances', 'Budgets', 'Centers for Medicare and Medicaid Services, U.S.', 'Forms and Records Control', 'Insurance Claim Reporting', 'Medicaid', 'Medicare', 'Needs Assessment', 'Reimbursement Mechanisms', 'Rural Health Services', 'Transportation of Patients', 'United States'] | 12,013,646 | [['J01.937.500.050', 'N02.421.297.879.100'], ['N03.219.463.060'], ['I01.409.418.750.600.310', 'N03.540.348.500.500.600.550'], ['N04.452.758.708.200.400'], ['N03.219.521.576.210'], ['N03.219.521.346.506.564.655', 'N03.706.615.693'], ['N03.219.521.346.506.564.663', 'N03.219.521.576.343.840', 'N03.706.615.696'], ['I02.594... | ['Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 |
ER targeting and retention of the HCV NS4B protein relies on the concerted action of multiple structural features including its transmembrane domains. | The Hepatitis C virus (HCV) NS4B protein, a multispanning endoplasmic reticulum (ER) membrane protein, generates intracellular rearrangements of ER-derived membranes, essential for HCV replication. In this study, we characterized NS4B elements involved in the process of targeting, association and retention in the ER me... | ['Amino Acid Motifs', 'Antigens, CD', 'Apyrase', 'Cell Line, Tumor', 'Endoplasmic Reticulum', 'Hepacivirus', 'Humans', 'Peptide Mapping', 'Protein Structure, Tertiary', 'Viral Nonstructural Proteins', 'Virus Replication'] | 20,001,747 | [['G02.111.570.820.709.275.500', 'G02.111.570.820.709.600.500'], ['D23.050.301.264.035', 'D23.101.100.110'], ['D08.811.277.040.050'], ['A11.251.210.190', 'A11.251.860.180'], ['A11.284.430.214.190.875.248'], ['B04.450.380', 'B04.820.578.344.475'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.196.181.400.454.72... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Changes in oxidative stress parameters and neurodegeneration markers in the brain of the senescence-accelerated mice SAMP-8. | The senescence-accelerated strains of mice (SAMP) are well-characterized animal models of senescence. Senescence may be related to enhanced production or defective control of reactive oxygen species, which lead to neuronal damage. Therefore, the activity of various oxidative-stress related enzymes was determined in the... | ['Aging, Premature', 'Animals', 'Biomarkers', 'Blotting, Western', 'Calpain', 'Catalase', 'Cerebral Cortex', 'Cyclin-Dependent Kinase 5', 'Cysteine Endopeptidases', 'Enzyme Activation', 'Female', 'Glutathione Peroxidase', 'Glutathione Reductase', 'Glutathione Transferase', 'Immunohistochemistry', 'Male', 'Mice', 'Mice,... | 16,542,809 | [['C23.888.069'], ['B01.050'], ['D23.101'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['D08.811.277.656.262.500.120', 'D08.811.277.656.300.200.120'], ['D08.811.682.732.332'], ['A08.186.211.200.885.287.500'], ['D08.811.913.696.620.682.700.646.500.500.500', 'D12.... | ['Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Anterior open bite--simplified non surgical technique to correct in adults. | Skeletal Anterior open bite abnormality in adults is probably the most difficult to correct in orthodontics just behind Skeletal Class III abnormality. Literature research shows various techniques to correct this problem, often via orthognathic surgery, but it was difficult to find in the literatures a simplified non-s... | ['Cephalometry', 'Female', 'Humans', 'Malocclusion, Angle Class III', 'Open Bite', 'Orthodontic Appliance Design', 'Orthodontic Brackets', 'Orthodontic Wires', 'Orthodontics, Corrective', 'Palatal Expansion Technique', 'Patient Care Planning', 'Prognathism', 'Retrognathia', 'Tooth Movement Techniques', 'Treatment Outco... | 25,881,379 | [['E01.370.600.024.250', 'E05.041.250', 'N06.850.505.200.100.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C07.793.494.650'], ['C07.793.494.825'], ['E05.320.274', 'E06.658.450', 'E06.912.675'], ['E06.658.453.255.500'], ['E06.658.453.684'], ['E06.658.578'], ['E06.658.578.458'], ['N04.590.233.624'], ['C05.500... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Does noise stress modulate effects of smoking/nicotine? Mood, vigilance, and EEG responses. | Effects of smoking multiple cigarettes on EEG, vigilance, and subjective state were assessed in a repeated measures design where noise level (high versus minimal) was crossed with nicotine dose (quasi-ad lib own versus 1.0 mg FTC nicotine machine-delivered dose versus 0.05 mg FTC nicotine machine-delivered dose). Vigil... | ['Adult', 'Affect', 'Arousal', 'Dose-Response Relationship, Drug', 'Electroencephalography', 'Humans', 'Male', 'Nicotine', 'Noise', 'Smoking', 'Stress, Physiological'] | 9,085,408 | [['M01.060.116'], ['F01.470.047'], ['F02.830.104', 'G11.561.035'], ['G07.690.773.875', 'G07.690.936.500'], ['E01.370.376.300', 'E01.370.405.245'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.132.760.570', 'D03.383.725.518'], ['G01.750.770.776.567', 'G16.500.275.600', 'N06.230.400', 'N06.850.460.610'], ['F01.... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Development of a colloidal gold immunochromatographic test strip for detection of lymphocystis disease virus in fish. | AIMS: To develop a gold immunochromatographic test strip for on-site rapid detection of lymphocystis disease virus (LCDV).METHODS AND RESULTS: Monodispersional colloidal gold and gold-labelled anti-LCDV monoclonal antibody (McAb) 2D11 were prepared and characterized by UV-visible spectroscopy and transmission electron ... | ['Animals', 'Antibodies, Monoclonal', 'Chromatography, Affinity', 'DNA Virus Infections', 'Enzyme-Linked Immunosorbent Assay', 'Female', 'Fish Diseases', 'Flounder', 'Gold Colloid', 'Iridoviridae', 'Mice', 'Mice, Inbred BALB C', 'Reproducibility of Results', 'Sensitivity and Specificity'] | 22,776,503 | [['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['E05.196.181.400.170'], ['C01.925.256'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['C22.362'], ['B01.050.150.900.493.418.438'], ['D01.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Fasting-induced reductions in cardiovascular and metabolic variables occur sooner in obese versus lean mice. | It is not uncommon for laboratory animals to be fasted prior to experimentation. Fasting evokes marked reductions in heart rate (HR), blood pressure (BP), heat production and oxygen consumption (VO(2)) in rodents. Mice with diet-induced obesity exhibit elevated HR and BP, and lower VO(2) and heat production in the fed ... | ['Animals', 'Blood Pressure', 'Body Size', 'Body Temperature', 'Catecholamines', 'Energy Intake', 'Energy Metabolism', 'Fasting', 'Heart Rate', 'Leptin', 'Locomotion', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Obesity', 'Thinness', 'Urine', 'Water'] | 21,127,345 | [['B01.050'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E01.370.600.115.100.160', 'E05.041.124.160', 'G07.100.100.160', 'G07.345.249.314'], ['E01.370.600.875.374', 'G07.110'], ['D02.092.311', 'D02.455.426.559.389.657.166.175'], ['G07.203.650.240.340'], ['G03.295'], ['F01.145.407.400', 'G07.203.650.240.587', 'G07.20... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Simulation in health care, a partnership between a training institute and a health care facility]. | A system of collaboration around simulation, between a health care facility and a training institute, has been put in place. It has enabled the challenges for both institutions to be identified, thereby confirming the need to continue this project. In this context, interprofessionalality and intergenerationality are ke... | ['Academies and Institutes', 'Health Facility Administration', 'Humans', 'Interinstitutional Relations', 'Simulation Training'] | 28,342,465 | [['N03.540.052'], ['N02.278.216', 'N04.452.442'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N04.452.822.400'], ['I02.903.847']] | ['Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Accelerated partial breast irradiation using intensity-modulated radiotherapy versus whole breast irradiation: 5-year survival analysis of a phase 3 randomised controlled trial. | BACKGROUND: Accelerated partial breast irradiation (APBI) has been introduced as an alternative treatment method for selected patients with early stage breast cancer (BC). Intensity-modulated radiotherapy (IMRT) has the theoretical advantage of a further increase in dose conformity compared with three-dimensional techn... | ['Adult', 'Aged', 'Breast', 'Breast Neoplasms', 'Female', 'Humans', 'Middle Aged', 'Radiotherapy, Intensity-Modulated'] | 25,605,582 | [['M01.060.116'], ['M01.060.116.100'], ['A01.236'], ['C04.588.180', 'C17.800.090.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E02.815.635.700.700', 'L01.313.500.750.100.710.600.550.700']] | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Signaling through the Smad pathway by insulin-like growth factor-binding protein-3 in breast cancer cells. Relationship to transforming growth factor-beta 1 signaling. | We previously demonstrated in T47D cells transfected to express the transforming growth factor-beta receptor type II (TGF-betaRII) that insulin-like growth factor binding protein-3 (IGFBP-3) could stimulate Smad2 and Smad3 phosphorylation, potentiate TGF-beta1-stimulated Smad phosphorylation, and cooperate with exogeno... | ['Activin Receptors, Type I', 'Breast Neoplasms', 'Cell Division', 'Cell Nucleus', 'DNA, Complementary', 'DNA-Binding Proteins', 'Dose-Response Relationship, Drug', 'Humans', 'Immunoblotting', 'Insulin-Like Growth Factor Binding Protein 3', 'Mutation', 'Phosphorylation', 'Precipitin Tests', 'Promoter Regions, Genetic',... | 11,751,851 | [['D08.811.913.696.620.682.700.062.500', 'D12.776.543.750.750.400.820.500.500'], ['C04.588.180', 'C17.800.090.500'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['D13.444.308.497.220', 'D13.444.600.223.500', 'D27.720.470.530.600.223.260']... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The c-kit proto-oncogene receptor is expressed on a subset of human CD3-CD4-CD8- (triple-negative) thymocytes. | The c-kit receptor is a tyrosine-kinase transmembrane receptor first identified as an oncogene in the HZ4-feline leukemia virus and later found to be important in hematopoiesis in mice. The ligand for this receptor (Steel factor) can stimulate hematopoiesis both in vitro and in vivo. To study the pattern of c-kit recep... | ['Antibodies, Monoclonal', 'Blotting, Western', 'Bone Marrow Cells', 'CD3 Complex', 'CD4 Antigens', 'CD8 Antigens', 'Cell Division', 'Cells, Cultured', 'Hematopoietic Cell Growth Factors', 'Humans', 'Proto-Oncogene Proteins', 'Proto-Oncogene Proteins c-kit', 'RNA, Messenger', 'Receptor Protein-Tyrosine Kinases', 'Recep... | 7,522,182 | [['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['A11.148', 'A15.378.316'], ['D23.050.301.264.894.095', 'D23.101.100.894.095'], ['D12.776.543.750.705.852.420.810.500', 'D1... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
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