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Sclerotherapy of bleeding esophageal varices using a thrombogenic cocktail. | The short- and long-term efficacy of a thrombogenic sclerosant (1% tetradecyl sulfate, thrombin, and cefazolin) was studied in 101 patients. The majority of patients had alcoholic cirrhosis with Child's C classification (84/101). Bleeding was controlled in 94 per cent of patients with the first sclerotherapy. In-hospit... | ['Adolescent', 'Adult', 'Aged', 'Cefazolin', 'Esophageal and Gastric Varices', 'Female', 'Gastrointestinal Hemorrhage', 'Humans', 'Liver Cirrhosis', 'Male', 'Middle Aged', 'Patient Compliance', 'Recurrence', 'Sclerotherapy', 'Sodium Tetradecyl Sulfate', 'Thrombin'] | 2,053,742 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['D02.065.589.099.249.160', 'D02.886.665.074.160', 'D03.633.100.300.249.160'], ['C06.405.117.240', 'C06.552.494.414'], ['C06.405.227', 'C23.550.414.788'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C06.552.630', 'C23.550.355.412'], ['M01.060.116.630'], ['F... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
New alkaloids from Phoebe grandis (Nees) Merr. | The alkaloidal extract of the leaves of Phoebe grandis (nees) merr. have provided two new minor alkaloids; phoebegrandine D (1), a proaporphine-tryptamine dimer, and phoebegrandine E (2), an indoloquinolizidine. This is the first report on the occurrence of an indoloquinolizidine in the Phoebe species. The crude extrac... | ['Alkaloids', 'Animals', 'Antimalarials', 'Lauraceae', 'Molecular Structure', 'Nuclear Magnetic Resonance, Biomolecular', 'Optical Rotation', 'Plant Leaves', 'Plasmodium falciparum', 'Spectrometry, Mass, Electrospray Ionization', 'Spectrophotometry, Infrared', 'Spectrophotometry, Ultraviolet'] | 16,835,089 | [['D03.132'], ['B01.050'], ['D27.505.954.122.250.100.085'], ['B01.650.940.800.575.912.250.595.400'], ['G02.111.570', 'G02.466'], ['E05.196.867.519.550'], ['G01.590.773'], ['A18.024.812'], ['B01.043.075.380.611.561'], ['E05.196.566.600'], ['E05.196.712.726.676', 'E05.196.867.826.676'], ['E05.196.712.726.802', 'E05.196.8... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A multi-season national estimate of adult influenza vaccination by U.S. office-based pediatricians, 2006-2011. | There is no national estimate of adult influenza vaccination by U.S. office-based pediatricians. De-identified patient-level data from an electronic healthcare claims database submitted to private and public insurers were analyzed for pediatric offices from the 2006-2007 through 2010-2011 seasons. An average of 321,000... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Child', 'Child, Preschool', 'Female', 'Humans', 'Infant', 'Influenza Vaccines', 'Insurance Claim Review', 'Male', 'Middle Aged', 'Primary Health Care', 'United States', 'Vaccination'] | 22,078,028 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['D20.215.894.899.302'], ['N03.219.521.576.215'], ['M01.060.116.630'], ['N04.590.233.727'], ['Z01.107.567.875'], ['E02.095.465.425.400.... | ['Named Groups [M]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
The DREAM protein is associated with thyroid enlargement and nodular development. | G protein-coupled receptors (GPCRs) are involved in the pathophysiology of a wide range of diseases and constitute an attractive therapeutic target. In the thyroid gland, TSH receptor (TSHR), a member of the GPCR family, is a major regulator of thyroid differentiation and function. Alterations in TSHR activity are ofte... | ['Animals', 'Biomarkers', 'Cattle', 'Cell Differentiation', 'Cell Line', 'Cell Proliferation', 'Cyclic AMP', 'Goiter', 'Humans', 'Kv Channel-Interacting Proteins', 'Mice', 'Mice, Transgenic', 'Peptides', 'Protein Binding', 'Receptors, Thyrotropin', 'Repressor Proteins', 'Signal Transduction', 'Thyroid Gland'] | 19,299,442 | [['B01.050'], ['D23.101'], ['B01.050.150.900.649.313.500.380.271'], ['G04.152'], ['A11.251.210'], ['G04.161.750', 'G07.345.249.410.750'], ['D03.633.100.759.646.138.395', 'D13.695.462.200', 'D13.695.667.138.395', 'D13.695.827.068.395'], ['C19.874.283'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.360.372.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Spectral studies on two genetic forms of the human serum proteinase inhibitor, alpha-1-antitrypsin. | alpha-1-antitrypsin, the major inhibitor of proteolytic enzymes in human serum, was isolated from normal individuals (protease inhibitor type MM) and from those with an inherited deficiency (protease inhibitor type ZZ) of circulatory protein. The two proteins were compared by circular dichroism spectroscopy, and by flu... | ['Circular Dichroism', 'Fluorescence', 'Humans', 'Phenotype', 'Protein Conformation', 'Spectrum Analysis', 'alpha 1-Antitrypsin'] | 311,355 | [['E05.196.867.151'], ['G01.358.500.505.650.665.500', 'G01.590.540.665.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G05.695'], ['G02.111.570.820.709'], ['E05.196.867'], ['D12.644.861.035', 'D12.776.124.050.070', 'D12.776.124.790.106.085', 'D12.776.377.715.085.085', 'D12.776.395.068', 'D12.776.872.035']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Involvement of CD14, toll-like receptors 2 and 4, and MyD88 in the host response to the fungal pathogen Cryptococcus neoformans in vivo. | The major capsular polysaccharide of Cryptococcus neoformans, glucuronoxylomannan (GXM), is recognized by Toll-like receptor 2 (TLR2), TLR4, and CD14. In these studies, mice deficient in CD14, TLR2, TLR4, and the TLR-associated adaptor protein, MyD88, were utilized to investigate the contribution of TLRs and CD14 to in... | ['Adaptor Proteins, Signal Transducing', 'Animals', 'Antigens, Differentiation', 'Cryptococcosis', 'Cryptococcus neoformans', 'Lipopolysaccharide Receptors', 'Lung Diseases, Fungal', 'Membrane Glycoproteins', 'Mice', 'Mice, Inbred C3H', 'Mice, Inbred C57BL', 'Mice, Knockout', 'Myeloid Differentiation Factor 88', 'Recep... | 15,322,035 | [['D12.644.360.024', 'D12.776.157.057', 'D12.776.476.024'], ['B01.050'], ['D23.050.301.264', 'D23.101.100'], ['C01.150.703.248'], ['B01.300.381.258.366', 'B01.300.930.316.366'], ['D12.776.395.550.448.100', 'D12.776.543.484.500.100', 'D12.776.543.550.418.100', 'D12.776.543.750.705.045', 'D23.050.301.264.900.045', 'D23.1... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Perioperative auricular electroacupuncture has no effect on pain and analgesic consumption after third molar tooth extraction. | BACKGROUND: Auricular acupuncture (AA) has been shown to alleviate acute and chronic pain. We investigated the effects of auricular electroacupuncture (AE) on pain and analgesic drug consumption in the first 48 h after unilateral mandibular third molar tooth extraction under local anesthesia in a prospective, randomize... | ['Acetaminophen', 'Adolescent', 'Adult', 'Analgesics', 'Anesthesia, Local', 'Double-Blind Method', 'Electroacupuncture', 'Female', 'Humans', 'Male', 'Mefenamic Acid', 'Molar, Third', 'Pain Measurement', 'Placebos', 'Prospective Studies', 'Time Factors', 'Tooth Extraction'] | 17,312,205 | [['D02.065.199.092.040', 'D02.092.146.113.092.040'], ['M01.060.057'], ['M01.060.116'], ['D27.505.696.663.850.014', 'D27.505.954.427.040'], ['E03.155.086.231'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['E02.186.250', 'E02.190.044.244', 'E02.331.399', 'E02.779.468.399', 'E02.... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Mechanistic studies of protein arginine deiminase 2: evidence for a substrate-assisted mechanism. | Citrullination, which is catalyzed by protein arginine deiminases (PADs 1-4 and 6), is a post-translational modification (PTM) that effectively neutralizes the positive charge of a guanidinium group by its replacement with a neutral urea. Given the sequence similarity of PAD2 across mammalian species and the genomic or... | ['Biocatalysis', 'Calcium', 'Humans', 'Hydrogen-Ion Concentration', 'Hydrolases', 'Isoenzymes', 'Kinetics', 'Protein-Arginine Deiminase Type 1', 'Protein-Arginine Deiminase Type 2', 'Protein-Arginine Deiminase Type 4', 'Protein-Arginine Deiminases', 'Solvents', 'Substrate Specificity'] | 24,989,433 | [['G02.111.086', 'G02.130.500', 'G03.105'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.300'], ['D08.811.277'], ['D08.811.348', 'D12.776.800.300'], ['G01.374.661', 'G02.111.490'], ['D08.811.277.721.250'], ['D08.811.277.721.313'], ['D08.811.277.721.500'],... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Attenuation coefficient estimates of mouse and rat chest wall. | Attenuation coefficients of intercostal tissues were estimated from chest walls removed postmortem (pm) from 41 6-to-7-week-old female ICR mice and 27 10-to-11-week-old female Sprague-Dawley rats. These values were determined from measurements through the intercostal tissues, from the surface of the skin to the parieta... | ['Animals', 'Biomedical Engineering', 'Female', 'In Vitro Techniques', 'Intercostal Muscles', 'Mice', 'Mice, Inbred ICR', 'Postmortem Changes', 'Rats', 'Rats, Sprague-Dawley', 'Thorax', 'Time Factors', 'Ultrasonography'] | 11,370,373 | [['B01.050'], ['H02.070', 'J01.293.140'], ['E05.481'], ['A02.633.567.900.500'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.510', 'B01.050.150.900.649.313.992.635.505.500.400.510'], ['C23.550.260.224.617'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700... | ['Organisms [B]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Application of redundancy analysis for aerobiological data. | An aerobiological survey was conducted through five consecutive years (2006-2010) at Worcester (England). The concentration of 20 allergenic fungal spore types was measured using a 7-day volumetric spore trap. The relationship between investigated fungal spore genera and selected meteorological parameters (maximum, min... | ['Air Microbiology', 'Air Pollutants', 'Allergens', 'England', 'Environmental Monitoring', 'Fungi', 'Spores, Fungal', 'Weather'] | 24,671,406 | [['H01.158.273.540.274.110', 'N06.850.425.110'], ['D27.888.284.101'], ['D23.050.063'], ['Z01.542.363.300'], ['N06.850.460.350.080', 'N06.850.780.375'], ['B01.300'], ['A11.870.710', 'A19.374.500', 'B05.775.710'], ['G16.500.275.063.725', 'G16.500.750.775', 'N06.230.300.100.725']] | ['Disciplines and Occupations [H]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
A lake-centric geospatial database to guide research and inform management decisions in an Arctic watershed in northern Alaska experiencing climate and land-use changes. | Lakes are dominant and diverse landscape features in the Arctic, but conventional land cover classification schemes typically map them as a single uniform class. Here, we present a detailed lake-centric geospatial database for an Arctic watershed in northern Alaska. We developed a GIS dataset consisting of 4362 lakes t... | ['Alaska', 'Animals', 'Arctic Regions', 'Climate', 'Climate Change', 'Databases, Factual', 'Decision Making', 'Lakes', 'Petroleum', 'Water Supply'] | 28,343,340 | [['Z01.107.567.875.580.100'], ['B01.050'], ['Z01.208'], ['G16.500.275.071', 'N06.230.300.100.250'], ['G16.500.175.374'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['F02.463.785.373'], ['G01.311.580', 'G16.500.275.280.500', 'N06.230.232.500'], ['D20.345.630', 'N06.230.132.258.630'], ['J01.293.821.500']] | ['Geographicals [Z]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Information Science [L]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 |
[Detection of human antigens on the surface of mouse cells transformed by chromosome transfer]. | Mouse embryo cells, transformed in vitro by the transfer of chromosomes from HeLa human tumour cells, express a surface antigen (s) also found on HeLa cells. This antigen(s), which has been detected both by indirect immunofluoresence and by a 125I-protein A binding assay, is not an antigen(s) shared by both Human and M... | ['Animals', 'Antigens, Surface', 'Cell Transformation, Neoplastic', 'Chromosomes', 'Fluorescent Antibody Technique', 'HeLa Cells', 'Humans', 'Mice', 'Radioligand Assay'] | 114,324 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Preservation of normal menstrual cycles in a patient with Sheehan's syndrome. | A unique case of Sheehan's syndrome is characterized by deficiencies of growth hormone, prolactin, thyrotropin, and ACTH. Clinically, it was manifested by adrenal and thyroid insufficiency with regular cyclical menses. Normal menstrual cycles do not preclude extensive hypothalamic-pituitary destruction. | ['Adult', 'Female', 'Humans', 'Hypopituitarism', 'Infant, Newborn', 'Menstruation', 'Pituitary Function Tests', 'Pituitary Hormones', 'Pregnancy', 'Puerperal Disorders', 'Thyroid Function Tests', 'Thyroid Hormones'] | 6,879,280 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.228.140.617.738.300', 'C19.700.482'], ['M01.060.703.520'], ['G08.686.605.428'], ['E01.370.374.605'], ['D06.472.699.631', 'D12.644.548.691'], ['G08.686.784.769'], ['C13.703.844'], ['E01.370.374.750'], ['D06.472.931']] | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
An image analysis pipeline for the semi-automated analysis of clinical fMRI images based on freely available software. | The technique of functional Magnetic Resonance Imaging (fMRI) has evolved in the last 15 years from a research concept into a clinically relevant medical procedure. In this study, an efficient, semi-automated and cost-effective solution for the analysis of fMRI images acquired in a clinical setting is presented relying... | ['Automation', 'Image Processing, Computer-Assisted', 'Magnetic Resonance Imaging', 'National Institutes of Health (U.S.)', 'Software', 'United States'] | 20,074,720 | [['J01.897.104'], ['L01.224.308'], ['E01.370.350.825.500'], ['I01.409.418.750.600.650.496', 'N03.540.052.750', 'N03.540.348.500.500.600.650.496'], ['L01.224.900'], ['Z01.107.567.875']] | ['Technology, Industry, and Agriculture [J]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 1 |
[Radionuclide pollution of the Vitebsk region]. | The 137Cs content has been determined for probes of flora, fauna, food, soil and autopsy material from Vitebsk Region. The 137Cs content was established not to be more, than the Republic Control Levels of 1992. The dynamic of 137Cs accumulation in potato for 1981-1995 has been shown. The presence of 137Cs was connected... | ['Air Pollutants, Radioactive', 'Cesium Radioisotopes', 'Food Contamination, Radioactive', 'Humans', 'Power Plants', 'Radiation Monitoring', 'Radioactive Hazard Release', 'Republic of Belarus', 'Soil Pollutants, Radioactive', 'Ukraine'] | 9,467,650 | [['D20.693.101', 'D27.888.284.101.393'], ['D01.268.549.125.500.300', 'D01.268.556.165.500.300', 'D01.496.180.300', 'D01.496.749.190', 'D01.552.528.160.500.300', 'D01.552.544.165.500.300'], ['J01.576.423.850.730.500.249.250', 'N06.850.460.400.250', 'N06.850.601.500.249.250', 'N06.850.810.125'], ['B01.050.150.900.649.313... | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
The association of job strain and health behaviours in men and women. | BACKGROUND: This study examined whether self-reported job strain, defined by the Karasek model was associated with some early, potentially modifiable cardiovascular (CVD)-related health characteristics.METHODS: Data were gathered in a 1989 cross-sectional survey of 3843 randomly selected men and women employees of 32 w... | ['Adult', 'Body Mass Index', 'Cardiovascular Diseases', 'Confidence Intervals', 'Dietary Fats', 'Employment', 'Exercise', 'Female', 'Health Behavior', 'Health Surveys', 'Humans', 'Logistic Models', 'Male', 'Minnesota', 'Occupational Health', 'Occupations', 'Odds Ratio', 'Risk Factors', 'Sex Factors', 'Smoking', 'Stress... | 9,222,783 | [['M01.060.116'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['C14'], ['E05.318.740.275', 'N05.715.360.750.220', 'N06.850.520.830.275'], ['D10.212.302', 'G07.203.300.375', 'J02.500.375'], ['N01.824.245'], ['G11.427.410.698.277', 'I03.350'], ['F01.145.488'], ['E05.318.3... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Psychiatry and Psycholog... | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
Psychosocial assessment of children with short stature: a preliminary report. | Previous studies that have examined the psychosocial adjustment of children with short stature have often been flawed, for two main reasons: first, a lack of sample homogeneity and, secondly, the measures of adjustment used have been limited in terms of their sensitivity. This paper examines psychological functioning i... | ['Affective Symptoms', 'Child', 'Dwarfism', 'Female', 'Growth Disorders', 'Humans', 'Intelligence', 'Learning Disabilities', 'Male', 'Personality Assessment', 'Personality Development', 'Self Concept', 'Social Adjustment', 'Social Behavior', 'Social Support', 'Sociometric Techniques'] | 7,734,805 | [['F01.145.126.100'], ['M01.060.406'], ['C05.116.099.343', 'C16.320.240', 'C19.297'], ['C23.550.393'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.752.543'], ['C10.597.606.150.550', 'C23.888.592.604.150.550', 'F03.625.562'], ['F04.513'], ['F01.752.747'], ['F01.752.747.792'], ['F01.145.813.621'], ['F01.145.81... | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
[Analgesic and neuroendocrinal response in heart surgery: II. Adreno-medullary response]. | In fifty-five patients who had undergone open-heart surgery, plasma levels of catecholamines and urinary excretion of adrenalin and noradrenalin were studied. We have divided the patients in three groups, according to the analgesic administered during the operation: group A, patients anesthesized with Pentazocina; grou... | ['Adrenal Medulla', 'Adult', 'Analgesics', 'Epinephrine', 'Extracorporeal Circulation', 'Heart Valve Diseases', 'Heart Valve Prosthesis', 'Humans', 'Middle Aged', 'Norepinephrine', 'Stimulation, Chemical', 'Sympathetic Nervous System'] | 1,234,783 | [['A06.300.071.265'], ['M01.060.116'], ['D27.505.696.663.850.014', 'D27.505.954.427.040'], ['D02.033.100.291.310', 'D02.092.063.291.310', 'D02.092.211.215.454', 'D02.092.311.461', 'D02.455.426.559.389.657.166.175.461'], ['E04.292'], ['C14.280.484'], ['E07.695.310'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M0... | ['Anatomy [A]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Multicenter feasibility study to assess external quality assessment panels for Xpert MTB/RIF assay in South Africa. | External quality assessment (EQA) for the Xpert MTB/RIF assay is part of the quality system required for clinical and laboratory practice. Five newly developed EQA panels that use different matrices, including a lyophilized sample (Vircell, Granada, Spain), a dried tube specimen (CDC), liquid (Maine Molecular Quality C... | ['Antitubercular Agents', 'Feasibility Studies', 'Humans', 'Laboratory Proficiency Testing', 'Molecular Diagnostic Techniques', 'Quality Control', 'Rifampin', 'South Africa', 'Tuberculosis, Multidrug-Resistant'] | 24,789,182 | [['D27.505.954.122.085.255'], ['E05.318.372.550', 'E05.337.675', 'N05.715.360.330.550', 'N06.850.520.450.550'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['J01.897.608.500', 'N04.761.700.512'], ['E01.370.225.880', 'E05.200.880', 'E05.393.520'], ['J01.897.608'], ['D03.633.400.811.700', 'D04.345.295.750.700'], ['Z... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Geographicals [Z]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
Incomplete proviral genome of mouse mammary tumour virus is present on chromosome Y of NIH Swiss and some genetically related mouse strains. | An incomplete proviral genome of endogenous mammary tumour virus (MMTV) was found in DNA of several strains of mice. This MMTV-related sequence was assigned to the Y chromosome since it was clearly observed in male mice only. This MMTV provirus contained a sequence related to LTR (long terminal repeat), but not to gag-... | ['Animals', 'DNA', 'DNA Probes', 'Female', 'Male', 'Mammary Tumor Virus, Mouse', 'Mice', 'Mice, Inbred Strains', 'Proviruses', 'Repetitive Sequences, Nucleic Acid', 'Y Chromosome'] | 1,849,209 | [['B01.050'], ['D13.444.308'], ['D13.444.600.223', 'D27.505.259.750.600.223', 'D27.720.470.530.600.223'], ['B04.613.807.124.500', 'B04.820.650.124.500'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520', 'B01.050.150.900.649.313.992.635.505.500.400'], ['B04.725'], ['G02.111.570.080.708', 'G05.360... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Dynamics of nuclear pore distribution in nucleoporin mutant yeast cells. | To follow the dynamics of nuclear pore distribution in living yeast cells, we have generated fusion proteins between the green fluorescent protein (GFP) and the yeast nucleoporins Nup49p and Nup133p. In nup133- dividing cells that display a constitutive nuclear pore clustering, in vivo analysis of GFP-Nup49p localizati... | ['Fungal Proteins', 'Gene Expression Regulation, Fungal', 'Green Fluorescent Proteins', 'Luminescent Proteins', 'Membrane Proteins', 'Mutation', 'Nuclear Envelope', 'Nuclear Pore Complex Proteins', 'Nuclear Proteins', 'Reproduction', 'Saccharomyces cerevisiae', 'Saccharomyces cerevisiae Proteins', 'Transformation, Gene... | 9,049,242 | [['D12.776.354'], ['G05.308.330'], ['D12.776.532.265'], ['D12.776.532'], ['D12.776.543'], ['G05.365.590'], ['A11.284.149.165.630', 'A11.284.149.450.700', 'A11.284.430.106.279.692', 'A11.284.835.514.700'], ['D12.776.157.530.750.625', 'D12.776.543.585.750.625'], ['D12.776.660'], ['G08.686.784'], ['B01.300.107.795.785.800... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Application of Bioorganic Fertilizer Significantly Increased Apple Yields and Shaped Bacterial Community Structure in Orchard Soil. | Application of bioorganic fertilizers has been reported to improve crop yields and change soil bacterial community structure; however, little work has been done in apple orchard soils where the biological properties of the soils are being degraded due to long-term application of chemical fertilizers. In this study, we ... | ['Bacteria', 'Base Sequence', 'Biodiversity', 'Biological Control Agents', 'Carbon', 'China', 'DNA, Bacterial', 'Fertilizers', 'Fruit', 'Malus', 'Microbial Consortia', 'Nitrogen', 'Nitrogen Fixation', 'Phylogeny', 'Plant Diseases', 'RNA, Ribosomal, 16S', 'Sequence Analysis, DNA', 'Soil', 'Soil Microbiology'] | 27,670,433 | [['B03'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G16.500.275.157.049', 'N06.230.124.049'], ['D20.215.113'], ['D01.268.150'], ['Z01.252.474.164'], ['D13.444.308.212'], ['D27.720.031.400'], ['A18.024.500', 'G07.203.300.562', 'J02.500.562'], ['B01.650.940.800.575.912.250.859.937.500.444'], ['G06.591.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 |
Diaper area granuloma of incontinence. | Granulomas in the diaper area developed in four patients; two male infants following surgery for Hirschsprung's disease and two female children with urinary (and/or fecal) incontinence. The use of the term 'Diaper area granuloma of incontinence' is suggested to describe these lesions seen in the elderly, as well as in ... | ['Buttocks', 'Child', 'Dermatitis, Contact', 'Fecal Incontinence', 'Female', 'Granuloma', 'Humans', 'Infant', 'Urinary Incontinence'] | 1,644,958 | [['A01.378.610.100'], ['M01.060.406'], ['C17.800.174.255', 'C17.800.815.255'], ['C06.405.469.860.300'], ['C15.604.515.292', 'C23.550.382'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['C12.777.934.852', 'C13.351.968.934.814', 'C23.888.942.343.800']] | ['Anatomy [A]', 'Named Groups [M]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Changes in receptor levels for thyrotropin releasing hormone, serotonin, and substance P in cervical spinal cord of Wobbler mouse: a quantitative autoradiography study during early and late stages of the motoneuron disease. | Receptor levels for thyrotropin releasing hormone (TRH) measured by quantitative autoradiography in the Wobbler mouse cervical spinal cord show receptor losses that may relate to the inherited loss of motoneurons, most pronounced late (at Stage 4) in the motoneuron disease. An age-related decrease of TRH and serotonin ... | ['Age Factors', 'Animals', 'Autoradiography', 'Disease Models, Animal', 'Mice', 'Mice, Inbred Strains', 'Motor Neuron Disease', 'Receptors, Neurokinin-1', 'Receptors, Serotonin', 'Receptors, Thyrotropin-Releasing Hormone', 'Spinal Cord', 'Time Factors'] | 8,828,585 | [['N05.715.350.075', 'N06.850.490.250'], ['B01.050'], ['E01.370.225.750.132', 'E05.200.750.132', 'E05.799.256'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520', 'B01.050.150.900.649.313.992.635.505.500.400'], ['C10.574.562', 'C10.668.467'], ['D12.7... | ['Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Prolactin anterior pituitary expression and circulating levels are reduced in obese and diabetic rats: role of TGF-â and TNF-á. | The levels of the hormone prolactin (PRL) are reduced in the circulation of patients with Type 2 diabetes and in obese children, and lower systemic PRL levels correlate with an increased prevalence of diabetes and a higher risk of metabolic syndrome. The secretion of anterior pituitary (AP) PRL in metabolic diseases ma... | ['Animals', 'Blood Glucose', 'Cell Line, Tumor', 'Diabetes Mellitus, Experimental', 'Gene Expression Regulation', 'Male', 'Obesity', 'Pituitary Gland, Anterior', 'Prolactin', 'RNA, Messenger', 'Rats', 'Rats, Wistar', 'Transforming Growth Factor beta', 'Tumor Necrosis Factor-alpha'] | 25,715,833 | [['B01.050'], ['D09.947.875.359.448.500'], ['A11.251.210.190', 'A11.251.860.180'], ['C18.452.394.750.074', 'C19.246.240', 'E05.598.500.374'], ['G05.308'], ['C18.654.726.500', 'C23.888.144.699.500', 'E01.370.600.115.100.160.120.699.500', 'G07.100.100.160.120.699.500'], ['A06.300.747.500', 'A06.688.357.750.500', 'A08.186... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Meta-analyzability Concerns in Meta-analyses. | Many studies to date have conducted a meta-analysis on a mix of effectiveness and superiority studies. This methodological flaw will lead to difficulties in interpreting the results. We addressed this issue in this article, illustrated our point with a simulated experiment, and re-analyzed a recent meta-analysis study ... | ['Humans', 'Meta-Analysis as Topic', 'Rehabilitation', 'Research Design'] | 30,690,008 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.370.500', 'E05.581.500.501', 'N05.715.360.325.515', 'N06.850.520.445.500'], ['E02.760.169.063.500', 'E02.831', 'H02.403.680.600', 'N02.421.784'], ['E05.581.500', 'H01.770.644.728']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Biomarkers Associated With Response to Regorafenib in Patients With Hepatocellular Carcinoma. | BACKGROUND & AIMS: In a phase 3 trial (RESORCE), regorafenib increased overall survival compared with placebo in patients with hepatocellular carcinoma (HCC) previously treated with sorafenib. In an exploratory study, we analyzed plasma and tumor samples from study participants to identify genetic, microRNA (miRNA), an... | ['Aged', 'Angiopoietin-1', 'Antineoplastic Agents', 'Biomarkers, Tumor', 'Carcinoma, Hepatocellular', 'Chemokine CCL3', 'Cystatin B', 'Female', 'Humans', 'Liver Neoplasms', 'Male', 'MicroRNAs', 'Middle Aged', 'Mutation', 'Oncogenes', 'Phenylurea Compounds', 'Progression-Free Survival', 'Pyridines', 'Randomized Controll... | 30,738,047 | [['M01.060.116.100'], ['D12.644.276.100.100.100', 'D12.776.467.100.100.100', 'D23.529.100.100.100'], ['D27.505.954.248'], ['D23.101.140'], ['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['D12.644.276.374.200.110.150', 'D12.644.276.374.200.600.150', 'D12.776.467.374.200.110.150... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Novel colorimetric method overcoming phosphorus interference during trace arsenic analysis in soil solution. | A sensitive (method detection limit, 2.0 microg As L(-1)) colorimetric determination of trace As(v) and As(iii) concentrations in the presence of soluble phosphorus (P) concentrations in soil/water extracts is presented. The proposed method modifies the malachite green method (MG) originally developed for P in soil and... | ['Arsenic', 'Colorimetry', 'Environmental Monitoring', 'Industrial Waste', 'Phosphorus', 'Soil Pollutants', 'Trace Elements', 'Water Pollutants, Chemical'] | 18,227,941 | [['D01.268.513.249'], ['E05.196.922.250'], ['N06.850.460.350.080', 'N06.850.780.375'], ['D20.944.420', 'N06.850.460.710.420'], ['D01.268.666'], ['D27.888.284.756'], ['D01.268.811', 'D27.505.696.494.555', 'G07.203.300.681.500.555', 'J02.500.681.500.555'], ['D27.888.284.903.655']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Prolactin levels in pregnancy: comparison of normal subjects with patients having micro- or macroadenomas after early bromocriptine withdrawal. | 14 previously infertile patients, 11 with radiologically abnormal fossae, and a mean prolactin level of 761 ng/ml (range 49-4,500 ng/ml) conceived on 19 occasions during bromocriptine treatment. So far, 15 healthy infants have been delivered. Treatment was withdrawn soon after conception and the subsequent prolactin ch... | ['Adenoma', 'Adult', 'Bromocriptine', 'Female', 'Humans', 'Infertility, Female', 'Pituitary Neoplasms', 'Pregnancy', 'Pregnancy Complications, Neoplastic', 'Prolactin'] | 3,972,334 | [['C04.557.470.035'], ['M01.060.116'], ['D03.132.327.412.100', 'D03.633.400.439.131', 'D03.633.400.562.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C13.351.500.365.700'], ['C04.588.322.609', 'C04.588.614.250.195.885.500.600', 'C10.228.140.211.885.500.600', 'C10.228.140.617.477.600', 'C10.228.140.617.738.67... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Effect of inter-population differences in the levels of selected factors on the differences in arterial blood pressure]. | According to the Pol-MONICA program the random selected population samples were studied in inhabitants of Warsaw or the Tarnobrzeg province . After excluding from analysis the subjects treated with the hypotensive++ or hypolipemic drugs the differences between populations studies with regard to range of mean pressure v... | ['Adult', 'Blood Pressure', 'Female', 'Humans', 'Hypertension', 'Life Style', 'Male', 'Middle Aged', 'Poland', 'Rural Population', 'Sex Factors', 'Urban Population'] | 2,267,363 | [['M01.060.116'], ['E01.370.600.875.249', 'G09.330.380.076'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['F01.829.458'], ['M01.060.116.630'], ['Z01.542.248.679'], ['N01.600.725'], ['N05.715.350.675', 'N06.850.490.875'], ['N01.600.900']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Social engagement during game play in persons with Alzheimer's: Innovative practice. | This study examined social engagement during game play among persons with Alzheimer's. In addition to being engaged with the game, engagement with players was noticed. Players would congratulate each other when they won, and they encouraged each other to do well. Natural conversation occurred as a result of playing the... | ['Aged', 'Aged, 80 and over', 'Alzheimer Disease', 'Female', 'Games, Recreational', 'Humans', 'Interpersonal Relations', 'Middle Aged', 'Self Concept'] | 28,068,784 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['I03.450.642.693.465'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.401'], ['M01.060.116.630'], ['F01.752.747.792']] | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Implementing collaborative care for depression treatment in primary care: a cluster randomized evaluation of a quality improvement practice redesign. | BACKGROUND: Meta-analyses show collaborative care models (CCMs) with nurse care management are effective for improving primary care for depression. This study aimed to develop CCM approaches that could be sustained and spread within Veterans Affairs (VA). Evidence-based quality improvement (EBQI) uses QI approaches wit... | ['California', 'Clinical Protocols', 'Cluster Analysis', 'Cooperative Behavior', 'Depression', 'Female', 'Health Care Surveys', 'Humans', 'Male', 'Middle Aged', 'Models, Organizational', 'Models, Psychological', 'Primary Health Care', 'Program Evaluation', 'Psychometrics', 'Quality Improvement', 'Registries', 'Regressi... | 22,032,247 | [['Z01.107.567.875.580.200', 'Z01.107.567.875.760.200'], ['E02.183', 'N05.715.360.330.125'], ['E05.318.740.250', 'N05.715.360.750.200', 'N06.850.520.830.250'], ['F01.145.813.115'], ['F01.145.126.350'], ['E05.318.308.980.344', 'N03.349.380.210', 'N05.425.210', 'N05.715.360.300.800.344', 'N06.850.520.308.980.344'], ['B01... | ['Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Named Groups [M]', 'Technology, Industry, and Agriculture [J]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena... | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
Discounting of monetary and directly consumable rewards. | We compared temporal and probability discounting of a nonconsumable reward (money) and three directly consumable rewards (candy, soda, and beer). When rewards were delayed, monetary rewards were discounted less steeply than directly consumable rewards, all three of which were discounted at equivalent rates. When reward... | ['Attitude', 'Economics', 'Humans', 'Reward'] | 17,362,379 | [['F01.100'], ['I01.261', 'N03.219'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.425.770.836']] | ['Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Karyotyping of human oocytes by chromosomal analysis of the second polar bodies. | This paper describes a method for obtaining metaphase chromosomes from human second polar bodies. The second polar body nucleus was injected into the cytoplasm of an enucleated oocyte, which is activated shortly after injection. When the polar body nucleus is transformed into a haploid pronucleus, treatment with okadai... | ['Animals', 'Cell Nucleus', 'Chromosomes, Human', 'Cytoplasm', 'Electric Stimulation', 'Embryo, Mammalian', 'Female', 'Genetic Techniques', 'Humans', 'Karyotyping', 'Metaphase', 'Mice', 'Microinjections', 'Okadaic Acid', 'Oocytes', 'Preimplantation Diagnosis'] | 10,065,862 | [['B01.050'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['A11.284.187.520.300', 'G05.360.162.520.300'], ['A11.284.430.214'], ['E05.723.402'], ['A16.254'], ['E05.393'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.385.315', 'E05.200.500.385.315', 'E05.242.385.315', 'E05.393.285.475'], ['G... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Two-component systems. | Originally known for their roles in a myriad of bacterial processes, the two-component signaling systems are now found far beyond the bacterial domain. Papon and Stock highlight the many interesting features of these widespread signaling systems. | ['Bacteria', 'Bacterial Physiological Phenomena', 'Evolution, Molecular', 'Genome, Microbial', 'Protein Interaction Domains and Motifs', 'Signal Transduction'] | 31,386,843 | [['B03'], ['G06.099'], ['G05.045.250', 'G16.075.250'], ['G05.360.340.358'], ['G02.111.570.820.709.275.750.500'], ['G02.111.820', 'G04.835']] | ['Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Colorectal stenting: an effective therapy for preoperative and palliative treatment. | PURPOSE: To demonstrate the effectiveness of preoperative and palliative colorectal stent placement in acute colonic obstruction.METHODS: Sixty-seven consecutive patients (mean age 67.3 years, range 25-93 years) with clinical and radiological signs of colonic obstruction were treated: 45 (67%) preoperatively and 22 (33... | ['Adult', 'Aged', 'Aged, 80 and over', 'Colectomy', 'Colon', 'Colonic Diseases', 'Colorectal Neoplasms', 'Colostomy', 'Female', 'Humans', 'Intestinal Obstruction', 'Male', 'Middle Aged', 'Neoadjuvant Therapy', 'Palliative Care', 'Prosthesis Design', 'Rectum', 'Retreatment', 'Stents', 'Tomography, X-Ray Computed', 'Trea... | 17,225,973 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E04.210.219'], ['A03.556.124.526.356', 'A03.556.249.249.356'], ['C06.405.469.158'], ['C04.588.274.476.411.307', 'C06.301.371.411.307', 'C06.405.249.411.307', 'C06.405.469.158.356', 'C06.405.469.491.307', 'C06.405.469.860.180'], ['E04.210.338.225', 'E04.5... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Resveratrol treatment reveals a novel role for HMGB1 in regulation of the type 1 interferon response in dengue virus infection. | Dengue is one of the most significant mosquito-borne virus diseases worldwide, particularly in tropical and subtropical regions. This study sought to examine the antiviral activity of resveratrol (RESV), a phytoalexin secreted naturally by plants, against dengue virus (DENV) infection. Our data showed that RESV inhibit... | ['Antiviral Agents', 'Cell Line, Tumor', 'Cell Nucleus', 'Dengue', 'Dengue Virus', 'HMGB1 Protein', 'Humans', 'Interferon Type I', 'Interferon-beta', 'Myxovirus Resistance Proteins', 'Promoter Regions, Genetic', 'Protein Binding', 'RNA Interference', 'RNA, Small Interfering', 'Resveratrol', 'Sirtuin 1', 'Stilbenes', 'V... | 28,216,632 | [['D27.505.954.122.388'], ['A11.251.210.190', 'A11.251.860.180'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['C01.920.500.270', 'C01.925.081.270', 'C01.925.782.350.250.214', 'C01.925.782.417.214'], ['B04.820.578.344.350.270'], ['D12.776.260.356.300', 'D12.776.660.235.400.600.300', 'D12.776.664.235.400.600.300... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Novel terpenoids, trichoderonic acids A and B isolated from Trichoderma virens, are selective inhibitors of family X DNA polymerases. | Trichoderonic acids A (1) and B (2), novel terpenoids, and (+)-heptelidic acid (3) isolated from cultures of a fungus, Trichoderma virens, and their structures were identified by spectroscopic analysis. These compounds selectively and competitively inhibited the activities of mammalian DNA polymerases beta, lambda (pol... | ['Acids', 'Cell Line, Tumor', 'DNA Nucleotidylexotransferase', 'DNA Polymerase beta', 'DNA-Directed DNA Polymerase', 'Female', 'Fungi', 'Genes, pol', 'HeLa Cells', 'Humans', 'Sesquiterpenes', 'Terpenes', 'Trichoderma'] | 20,378,979 | [['D01.029'], ['A11.251.210.190', 'A11.251.860.180'], ['D08.811.913.696.445.308.325'], ['D08.811.913.696.445.308.300.112'], ['D08.811.913.696.445.308.300'], ['B01.300'], ['G05.360.340.024.340.364.875.667', 'G05.360.340.358.024.875.667', 'G05.360.340.358.840.500.667'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Temporal estimation of the 3d guide-wire position using 2d X-ray images. | We present a method for realtime online 3d reconstruction of a guide-wire or catheter using 2d X-ray images, which do not have to be recorded from different viewpoints. No special catheters or sensors are needed. Given a 3d patient data set and the projection parameters, we use recursive probability density propagation... | ['Algorithms', 'Angiography', 'Blood Vessel Prosthesis', 'Embolization, Therapeutic', 'Humans', 'Imaging, Three-Dimensional', 'Pattern Recognition, Automated', 'Prosthesis Implantation', 'Radiographic Image Enhancement', 'Radiographic Image Interpretation, Computer-Assisted', 'Reproducibility of Results', 'Sensitivity ... | 20,426,011 | [['G17.035', 'L01.224.050'], ['E01.370.350.700.060', 'E01.370.370.050'], ['E07.695.110'], ['E02.520.360', 'E02.926.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.400', 'L01.224.308.410'], ['L01.399.750'], ['E04.650'], ['E01.370.350.600.350.700', 'E01.370.350.700.700', 'L01.224.308.380.600'], ['E0... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
The critical micelle concentration of lecithin in bulk oils and medium chain triacylglycerol is influenced by moisture content and total polar materials. | Effects of different moisture contents and oxidised compounds on the critical micelle concentration (CMC) of lecithin were determined in bulk oils and in medium-chain triacylglycerols (MCT). CMC of lecithin in MCT was significantly higher than that in other vegetable oils including olive, soybean, corn, and rapeseed oi... | ['Corn Oil', 'Lecithins', 'Micelles', 'Oxidation-Reduction', 'Plant Oils', 'Rapeseed Oil', 'Triglycerides'] | 29,739,582 | [['D10.212.302.380.370', 'D10.212.507.340', 'D10.627.700.240', 'D20.215.784.750.240', 'G07.203.300.375.400.250', 'J02.500.375.400.250'], ['D10.570.755.375.760.400.800.806', 'D20.215.784.500.492'], ['D05.374', 'D26.255.560'], ['G02.700', 'G03.295.531'], ['D10.627.700', 'D20.215.784.750'], ['D10.627.700.066', 'D20.215.78... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Effectiveness of supportive supervision on the consistency of integrated community cases management skills of the health extension workers in 113 districts of Ethiopia. | BACKGROUND: Consistency in the adherence to integrated Community Case Management (iCCM) protocols for common childhood illnesses provided by Ethiopia's Health Extension Program (HEP) frontline workers. One approach is to provide regular clinical mentoring to the frontline health workers of the HEP at their health posts... | ['Case Management', 'Child Health Services', 'Child, Preschool', 'Clinical Competence', 'Community Health Services', 'Community Health Workers', 'Delivery of Health Care, Integrated', 'Diarrhea', 'Ethiopia', 'Humans', 'Infant', 'Infant, Newborn', 'Inservice Training', 'Malaria', 'Organization and Administration', 'Pneu... | 25,845,075 | [['N04.590.233.624.250'], ['N02.421.143.130'], ['M01.060.406.448'], ['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['N02.421.143'], ['M01.526.485.067.080', 'N02.360.067.080'], ['N04.590.374.142', 'N05.300.262'], ['C23.888.821.214'], ['Z01.058.290.120.310'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060... | ['Health Care [N]', 'Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Diseases [C]', 'Geographicals [Z]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Causes and consequences of early-life health. | We examine the consequences of child health for economic and health outcomes in adulthood, using height as a marker of childhood health. After reviewing previous evidence, we present a conceptual framework that highlights data limitations and methodological problems that complicate the study of this topic. We then pres... | ['Adolescent', 'Adult', 'Aged', 'Body Height', 'Child', 'Child Development', 'Child, Preschool', 'Educational Status', 'Employment', 'Family Characteristics', 'Female', 'Health Status', 'Humans', 'Income', 'Infant', 'Infant, Newborn', 'Longitudinal Studies', 'Male', 'Middle Aged', 'Pregnancy', 'Prenatal Exposure Delaye... | 21,302,429 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['E01.370.600.115.100.160.100', 'E05.041.124.160.500', 'G07.100.100.160.100', 'G07.345.249.314.100'], ['M01.060.406'], ['F01.525.200', 'G07.345.374.750'], ['M01.060.406.448'], ['N01.824.196'], ['N01.824.245'], ['F01.829.263.315', 'I01.240.361', 'I01.880.853.150.42... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Alterations in the water intake caused by central inhibition of angiotensin-converting enzyme in the rat. | In the present study we investigated the effects of central (i.c.v.) and subcutaneous (s.c.) injections of a 2 micrograms dose of lisinopryl, an inhibitor of angiotensin I(ANGI)-converting enzyme (CE), on water intake. I.c.v. but not s.c. injection of lisinopryl abolished drinking in response to s.c. isoprenaline (100 ... | ['Angiotensin-Converting Enzyme Inhibitors', 'Animals', 'Cerebral Ventricles', 'Drinking Behavior', 'Enalapril', 'Injections, Intraventricular', 'Injections, Subcutaneous', 'Isoproterenol', 'Lisinopril', 'Male', 'Rats', 'Reference Values', 'Saline Solution, Hypertonic', 'Time Factors'] | 1,317,024 | [['D27.505.519.389.745.085'], ['B01.050'], ['A08.186.211.140'], ['F01.145.317'], ['D12.644.456.345.360'], ['E02.319.267.530.550'], ['E02.319.267.530.620'], ['D02.033.100.291.439', 'D02.092.063.291.439', 'D02.092.311.649', 'D02.455.426.559.389.657.166.175.649'], ['D12.644.456.345.600'], ['B01.050.150.900.649.313.992.635... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Excitons and disorder in molecular nanotubes: a 2D electronic spectroscopy study and first comparison to a microscopic model. | The efficiency of natural light-harvesting complexes relies on delocalization and directed transfer of excitation energy on spatially well-defined arrangements of molecular absorbers. Coherent excitation delocalization and long-range molecular order are also central prerequisites for engineering energy flows in bioinsp... | ['Absorption', 'Electrons', 'Models, Molecular', 'Nanotubes', 'Spectrum Analysis'] | 20,701,329 | [['G01.015', 'G02.010', 'G03.015', 'G03.787.024', 'G07.690.725.015'], ['G01.249.335', 'G01.358.500.750'], ['E05.599.595'], ['J01.637.512.850'], ['E05.196.867']] | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
The discovery of potent antagonists of NPBWR1 (GPR7). | The synthesis and evaluation of small molecule antagonists of the G protein-coupled receptor NPBWR1 (GPR7) are reported for the first time. [4-(5-Chloropyridin-2-yl)piperazin-1-yl][(1S,2S,4R)-4-{[(1R)-1-(4-methoxyphenyl)ethyl]amino}-2-(thiophen-3-yl)cyclohexyl]methanone (1) emerged as a hit from a high-throughput scree... | ['Animals', 'Benzylamines', 'Crystallography, X-Ray', 'Dose-Response Relationship, Drug', 'Humans', 'Mice', 'Models, Molecular', 'Molecular Structure', 'Piperazine', 'Piperazines', 'Receptors, G-Protein-Coupled', 'Receptors, Neuropeptide', 'Stereoisomerism', 'Structure-Activity Relationship'] | 22,197,390 | [['B01.050'], ['D02.092.200', 'D02.455.426.559.389.140.210'], ['E05.196.309.742.225'], ['G07.690.773.875', 'G07.690.936.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649.313.992.635.505.500'], ['E05.599.595'], ['G02.111.570', 'G02.466'], ['D03.383.606.768'], ['D03.383.606'], ['D12.776.543.75... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Role of Cbfa1 in ameloblastin gene transcription. | Ameloblastin is a tooth-specific extracellular matrix protein that is thought to play a role in enamel crystal formation in the developing dentition. The murine ameloblastin promoter functions in a cell type-specific manner and contains cis-acting elements that function both to enhance and to suppress transcription. Th... | ['Animals', 'Binding Sites', 'Cell Line', 'Core Binding Factor Alpha 1 Subunit', 'DNA', 'Dental Enamel Proteins', 'Mice', 'Mutagenesis, Site-Directed', 'Neoplasm Proteins', 'Promoter Regions, Genetic', 'Transcription Factors', 'Transcription, Genetic'] | 11,451,945 | [['B01.050'], ['G02.111.570.120'], ['A11.251.210'], ['D12.776.930.155.200.100'], ['D13.444.308'], ['D12.776.231'], ['B01.050.150.900.649.313.992.635.505.500'], ['E05.393.420.601.575'], ['D12.776.624'], ['G02.111.570.080.689.675', 'G05.360.080.689.675', 'G05.360.340.024.340.137.750.680'], ['D12.776.930'], ['G02.111.873'... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Analysis of staphylococcal enterotoxin B by the polyacrylamide electrophoresis technique. | The electrophoretic mobility of enterotoxin B was investigated through the use of the disc electrophoresis technique. Ideal patterns were developed with a 7.5% acrylamide gel system (pH 4.3). The toxin can be separated and identified from other complex proteins such as serum or suspect samples of foods by this techniqu... | ['Animals', 'Biological Assay', 'Blood Proteins', 'Chickens', 'Electrophoresis, Disc', 'Enterotoxins', 'Food Analysis', 'Haplorhini', 'Injections, Intravenous', 'Methods', 'Staphylococcus', 'Temperature'] | 4,999,524 | [['B01.050'], ['E05.091'], ['D12.776.124'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['E05.196.401.402.236', 'E05.301.300.319.403'], ['D23.946.330'], ['E05.362', 'J01.576.423.850.100'], ['B01.050.150.900.649.313.988.400'], ['E02.319.267.082.750', 'E02.319.267.530.540'], ['E05.581'], ['B03.300.390... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Translation of the FMR1 mRNA is not influenced by AGG interruptions. | The fragile X mental retardation 1 (FMR1) gene contains a CGG-repeat element within its 5' untranslated region (5'UTR) which, for alleles with more than approximately 40 repeats, increasingly affects both transcription (up-regulation) and translation (inhibition) of the repeat-containing RNA with increasing CGG-repeat ... | ['Base Sequence', 'Databases, Nucleic Acid', 'Fragile X Mental Retardation Protein', 'Molecular Sequence Data', 'Protein Biosynthesis', 'RNA, Messenger'] | 19,752,155 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['L01.313.500.750.300.188.400.300.500', 'L01.313.500.750.300.188.400.325.630', 'L01.470.750.750.300.500', 'L01.470.750.750.325.630'], ['D12.776.157.725.061', 'D12.776.631.299', 'D12.776.664.962.124'], ['L01.453.245.667'], ['G02.111.660.871', 'G03.734.871', 'G0... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Auditory Brainstem Evoked Response: response patterns of full-term and premature infants. | UNLABELLED: Auditory Brainstem Response (ABR) is important for the early diagnosis of hearing impairment in infants.AIM: To compare ABR responses in full-term and premature infants; gender and ear were taken into account.METHODS: A cross-sectional prospective cohort study was carried out. We evaluated 36 full-term and ... | ['Age Factors', 'Cross-Sectional Studies', 'Ear', 'Electrophysiology', 'Evoked Potentials, Auditory, Brain Stem', 'Female', 'Hearing', 'Hearing Loss', 'Humans', 'Infant', 'Infant, Newborn', 'Infant, Premature', 'Male', 'Neonatal Screening', 'Prospective Studies', 'Risk Factors', 'Sex Factors', 'Statistics, Nonparametri... | 21,180,941 | [['N05.715.350.075', 'N06.850.490.250'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['A01.456.313', 'A09.246'], ['H01.158.344.528', 'H01.158.782.236'], ['G07.265.216.500.370.300', 'G07.888.250.300', 'G11.561.200.500.370.300'], ['F02.830.816.263', 'G07.888.500', 'G11.561.790.263'], ['... | ['Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Off-pump total myocardial revascularization in patients with left ventricular dysfunction. | OBJECTIVE: To assess off-pump myocardial revascularization in patients with significant left ventricular dysfunction.METHODS: Four hundred and five patients with an ejection fraction less than 35% underwent myocardial revascularization without extracorporeal circulation. The procedure was performed with the aid of a su... | ['Adult', 'Aged', 'Aged, 80 and over', 'Anastomosis, Surgical', 'Atrial Fibrillation', 'Coronary Artery Bypass, Off-Pump', 'Female', 'Humans', 'Male', 'Mediastinitis', 'Middle Aged', 'Myocardial Infarction', 'Renal Insufficiency', 'Reoperation', 'Risk Assessment', 'Severity of Illness Index', 'Stroke Volume', 'Treatmen... | 17,768,577 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E04.035'], ['C14.280.067.198', 'C23.550.073.198'], ['E04.100.376.719.332.199', 'E04.100.814.868.750.199', 'E04.928.220.520.220.189'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C08.846.187.790'], ['M01.060.116.630'], ['C14.280.647.500', 'C14.907.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Blood gastrin levels after electrical stimulation of the vagus (author's transl)]. | Acid secretion from the cells bordering the gastric fundus may be stimulated by a direct action of histamine or pentagastrin... or from electrical stimulation of the vagus as used to control vagotomy. It is not known, however, whether this latter effect is due to direct stimulation of the lining cells or follows hypers... | ['Animals', 'Dogs', 'Electric Stimulation', 'Gastrins', 'Humans', 'Hydrogen-Ion Concentration', 'Vagus Nerve'] | 7,204,515 | [['B01.050'], ['B01.050.150.900.649.313.750.250.216.200'], ['E05.723.402'], ['D06.472.317.413', 'D06.472.699.280', 'D12.644.400.320', 'D12.644.548.280', 'D12.776.631.650.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.300'], ['A08.800.050.050.925', 'A08.800.050.600.825', 'A08.800.800.060.920', 'A08.800.80... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Children with cancer share their views: tell the truth but leave room for hope. | AIM: One in five children diagnosed with cancer will die from the disease. The aim of the study was to explore how children with cancer want to receive bad news about their disease, such as when no more treatment options are available.METHODS: We conducted individual interviews with ten children with cancer, aged seven... | ['Adolescent', 'Child', 'Communication', 'Female', 'Hope', 'Humans', 'Interviews as Topic', 'Male', 'Neoplasms', 'Physician-Patient Relations', 'Truth Disclosure'] | 27,272,911 | [['M01.060.057'], ['M01.060.406'], ['F01.145.209', 'L01.143'], ['F01.470.572'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.420', 'L01.399.250.520', 'N05.715.360.300.400', 'N06.850.520.308.420'], ['C04'], ['F01.829.401.650.675', 'N05.300.660.625'], ['F01.829.401.046.800', 'I01.880.604.583.080.134.800... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 0 |
My brother's gatekeeper. | When doctors launch their own managed care ventures, they soon find that cost control means care control. And in policing their own, they must resort to the techniques used by other health plans--gatekeepers and all. | ['American Medical Association', 'Cost Control', 'Group Practice, Prepaid', 'Independent Practice Associations', 'Managed Care Programs', 'Ownership', 'Patient Care', 'Physician Executives', 'Preferred Provider Organizations', 'Referral and Consultation', 'United States', 'Utilization Review'] | 9,344,025 | [['N03.540.828.589.274'], ['N03.219.151.160'], ['N04.452.758.244.400'], ['N03.219.521.576.343.800.450', 'N04.452.758.244.450', 'N04.452.758.745.450', 'N04.590.374.410.450'], ['N03.219.521.576.343.800', 'N04.590.374.410'], ['I01.880.604.583.594', 'N04.452.633'], ['E02.760', 'N02.421.585'], ['M01.526.070.700', 'M01.526.4... | ['Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Geographicals [Z]'] | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Platycodin D, a triterpenoid saponin from Platycodon grandiflorum, induces G2/M arrest and apoptosis in human hepatoma HepG2 cells by modulating the PI3K/Akt pathway. | Platycodin D (PD) is one of triterpenoid saponins isolated from the roots of Platycodon grandiflorum. In the present study, we aimed at examining the antitumor activity of PD against human hepatoma HepG2 cancer cells and investigated the underlying molecular mechanisms of PD-induced apoptosis in HepG2 cells. PD signifi... | ['Apoptosis', 'Carcinoma, Hepatocellular', 'Cell Cycle Checkpoints', 'Elafin', 'G2 Phase Cell Cycle Checkpoints', 'Hep G2 Cells', 'Humans', 'Liver Neoplasms', 'Platycodon', 'Proto-Oncogene Proteins c-akt', 'Saponins', 'Signal Transduction', 'Triterpenes'] | 24,048,756 | [['G04.146.954.035'], ['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['G04.144.109'], ['D12.644.822.437', 'D12.776.645.437'], ['G04.144.109.500', 'G04.144.500.340.500'], ['A11.251.860.180.432', 'A11.436.348.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.274.... | ['Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
All rodents are not the same: a modern synthesis of cortical organization. | Rodents are a major order of mammals that is highly diverse in distribution and lifestyle. Five suborders, 34 families, and 2,277 species within this order occupy a number of different niches and vary along several lifestyle dimensions such as diel pattern (diurnal vs. nocturnal), terrain niche, and diet. For example, ... | ['Animals', 'Biological Evolution', 'Cerebral Cortex', 'Phylogeny', 'Rodentia', 'Species Specificity'] | 21,701,141 | [['B01.050'], ['G05.045', 'G16.075'], ['A08.186.211.200.885.287.500'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['B01.050.150.900.649.313.992'], ['G16.824']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Information Science [L]'] | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Extension of Drosophila lifespan by cinnamon through a sex-specific dependence on the insulin receptor substrate chico. | Cinnamon is a spice commonly used worldwide to flavor desserts, fruits, cereals, breads, and meats. Numerous health benefits have been attributed to its consumption, including the recent suggestion that it may decrease blood glucose levels in people with diabetes. Insulin signaling is an integral pathway regulating the... | ['Acrolein', 'Animals', 'Cinnamomum zeylanicum', 'Coumarins', 'Drosophila Proteins', 'Drosophila melanogaster', 'Female', 'Fertility', 'HSP70 Heat-Shock Proteins', 'Insulin', 'Insulin Receptor Substrate Proteins', 'Longevity', 'Male', 'Mitochondria', 'Motor Activity', 'Sex Characteristics', 'Signal Transduction', 'Spic... | 25,456,850 | [['D02.047.122'], ['B01.050'], ['B01.650.940.800.575.912.250.595.400.149.500'], ['D03.383.663.283.446', 'D03.633.100.150.446'], ['D12.776.093.500.462'], ['B01.050.500.131.617.720.500.500.750.310.250.500'], ['G08.686.210'], ['D12.776.580.216.375'], ['D06.472.699.587.200.500.625', 'D12.644.548.586.200.500.625'], ['D12.64... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Microbiological quality of sewage sludge in Greece disposed for agricultural use. | For the disposal of sewage, sludge landfill is currently the practice adopted in Greece. Thirteen wastewater treatment plants located throughout Greece (islands excluded) were investigated over a period of 1 year in order to determine sludge microbiological quality. The time of exposure of the samples to environmental ... | ['Agriculture', 'Animals', 'Conservation of Natural Resources', 'Enterobacteriaceae', 'Environmental Monitoring', 'Feces', 'Food Contamination', 'Parasites', 'Population Dynamics', 'Salmonella', 'Sewage', 'Vegetables', 'Waste Disposal, Fluid'] | 11,672,484 | [['J01.040'], ['B01.050'], ['J01.256', 'N06.230.080'], ['B03.440.450.425', 'B03.660.250.150'], ['N06.850.460.350.080', 'N06.850.780.375'], ['A12.459'], ['J01.576.423.850.730.500.249', 'N06.850.460.400', 'N06.850.601.500.249'], ['B01.050.500.714'], ['I01.240.600', 'N01.224.625', 'N06.850.505.400.700'], ['B03.440.450.425... | ['Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Health Care [N]', 'Anatomy [A]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 |
Innominate osteotomy for the treatment of Legg-Calv?-Perthes disease. | A retrospective study was performed in 37 patients who underwent innominate osteotomy for the treatment of Legg-Calv?-Perthes disease. The majority of the patients (81%) were more than 6 years old, and the mean age was 7 years and 6 months. Thirty five hips were Catterall group III or IV, and 2 hips that had clinical a... | ['Age Factors', 'Child', 'Child, Preschool', 'Female', 'Humans', 'Legg-Calve-Perthes Disease', 'Male', 'Osteotomy'] | 8,826,786 | [['N05.715.350.075', 'N06.850.490.250'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C05.116.852.175.570'], ['E04.555.580']] | ['Health Care [N]', 'Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The binding of substrate analogs to phosphotriesterase. | Phosphotriesterase (PTE) from Pseudomonas diminuta catalyzes the detoxification of organophosphates such as the widely utilized insecticide paraoxon and the chemical warfare agent sarin. The three-dimensional structure of the enzyme is known from high resolution x-ray crystallographic analyses. Each subunit of the homo... | ['Aryldialkylphosphatase', 'Chemical Warfare Agents', 'Cholinesterase Inhibitors', 'Crystallography, X-Ray', 'Esterases', 'Models, Chemical', 'Molecular Mimicry', 'Organophosphates', 'Organophosphorus Compounds', 'Protein Structure, Quaternary', 'Protein Structure, Tertiary', 'Pseudomonas', 'Sarin', 'Zinc'] | 10,871,616 | [['D08.811.277.352.660.500'], ['D27.720.777.300', 'D27.888.569.612.150', 'J01.637.870.900.200'], ['D27.505.519.389.275', 'D27.505.519.625.120.300', 'D27.505.696.577.120.300'], ['E05.196.309.742.225'], ['D08.811.277.352'], ['E05.599.495'], ['G02.111.560', 'G05.545', 'G16.012.750.500'], ['D02.705.400'], ['D02.705'], ['G0... | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Effects of facial lobectomy on goldfish feeding behavior. | The role of the facial lobe (FL) of goldfish in feeding behavior (search, pick up and ingestion) was investigated using the ablation method. Facial lobectomy (FLX) was performed on 10 fish, five of which were also fitted with blinders (BLs). It was found that FLX did not have any apparent effect on feeding behavior; ho... | ['Animals', 'Behavior, Animal', 'Face', 'Feeding Behavior', 'Frontal Lobe', 'Goldfish'] | 18,671,989 | [['B01.050'], ['F01.145.113'], ['A01.456.505'], ['F01.145.113.547', 'F01.145.407', 'G07.203.650.353'], ['A08.186.211.200.885.287.500.270'], ['B01.050.150.900.493.200.244.248.480']] | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The importance of improving the quality of emergency surgery for a regional quality collaborative. | INTRODUCTION: Within a large, statewide collaborative, significant improvement in surgical quality has been appreciated (9.0% reduction in morbidity for elective general and vascular surgery). Our group has not noted such quality improvement in the care of patients who had emergency operations. With this work, we aim t... | ['Cost Savings', 'Emergency Treatment', 'Evidence-Based Emergency Medicine', 'Guideline Adherence', 'Hospital Mortality', 'Humans', 'Michigan', 'Quality Assurance, Health Care', 'Quality Improvement', 'Regional Medical Programs', 'Risk Factors', 'Surgical Procedures, Operative', 'Treatment Outcome'] | 23,470,507 | [['N03.219.151.160.200'], ['E02.365'], ['H02.249.750.500', 'H02.403.200.400.500'], ['N04.761.337', 'N05.715.360.395'], ['E05.318.308.985.550.400', 'N01.224.935.698.400', 'N06.850.505.400.975.550.400', 'N06.850.520.308.985.550.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.107.567.875.350.500', 'Z01.107.5... | ['Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Geographicals [Z]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 |
Activation of Gáq subunits up-regulates the expression of the tumor suppressor Fhit. | The tumor suppressor Fhit protein is defective or absent in many tumor cells due to methylation, mutation or deletion of the FHIT gene. Despite numerous attempts to unravel the functions of Fhit, the mechanisms by which the function and expression of Fhit are regulated remain poorly understood. We have recently shown t... | ['Acid Anhydride Hydrolases', 'Cell Line', 'GTP-Binding Protein alpha Subunits, Gq-G11', 'Humans', 'MAP Kinase Kinase Kinases', 'Neoplasm Proteins', 'Protein Biosynthesis', 'Protein Kinase C', 'Signal Transduction', 'Up-Regulation'] | 23,993,961 | [['D08.811.277.040'], ['A11.251.210'], ['D08.811.277.040.330.300.200.100.300', 'D12.644.360.360.100.300', 'D12.776.157.325.332.100.300', 'D12.776.476.375.100.300', 'D12.776.543.325.100.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.913.696.620.682.700.559', 'D12.644.360.400', 'D12.776.476.400'], ['D1... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Practical aspects in expression and purification of membrane proteins for structural analysis. | A surge of membrane protein structures in the last few years can be attributed to advances in technologies starting at the level of genomes, to highly efficient expression systems, stabilizing conformational flexibility, automation of crystallization and data collection for screening large numbers of crystals and the m... | ['Animals', 'Bacterial Outer Membrane Proteins', 'DNA-Binding Proteins', 'Endopeptidases', 'Escherichia coli', 'Escherichia coli Proteins', 'Gene Expression', 'HEK293 Cells', 'Humans', 'Membrane Proteins', 'Porins', 'Rhodopsin'] | 23,132,053 | [['B01.050'], ['D12.776.097.120', 'D12.776.543.100'], ['D12.776.260'], ['D08.811.277.656.300'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D12.776.097.275'], ['G05.297'], ['A11.251.210.172.750', 'A11.436.334'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.543'], ['D12.776.157.530.400.500', ... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A pharmacokinetic and pharmacodynamic comparison of Sinemet CR (50/200) and standard Sinemet (25/100). | Seventeen patients with advanced Parkinson's disease who had fluctuations in motor performance while taking standard Sinemet (STD) 25/100 underwent daylong pharmacokinetic and clinical observation studies while taking both STD and Sinemet CR, a new controlled-release formulation containing 50 mg carbidopa and 200 mg le... | ['Antiparkinson Agents', 'Carbidopa', 'Drug Combinations', 'Female', 'Humans', 'Levodopa', 'Male', 'Middle Aged', 'Parkinson Disease', 'Tyrosine'] | 2,586,762 | [['D27.505.954.427.090.050'], ['D02.092.311.200.538.200', 'D02.442.200', 'D02.455.426.559.389.657.166.175.200.538.200'], ['D26.310'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.092.311.200.480', 'D02.455.426.559.389.657.166.175.200.480', 'D12.125.072.050.685.400.500', 'D12.125.072.050.875.130.500'], ['M01.0... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Named Groups [M]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Prediction of permeability coefficients of compounds through caco-2 cell monolayer using artificial neural network analysis. | Artificial neural network (ANN) analysis was used to predict the permeability of selected compounds through Caco-2 cell monolayers. Previously reported models, which were shown to be useful in the prediction of permeability values, use many structural parameters. More complex equations have also been proposed using bot... | ['Algorithms', 'Caco-2 Cells', 'Cell Membrane Permeability', 'Chromatography, High Pressure Liquid', 'Diffusion', 'Famotidine', 'Histamine H2 Antagonists', 'Humans', 'Linear Models', 'Models, Molecular', 'Molecular Weight', 'Neural Networks, Computer', 'Predictive Value of Tests', 'Software'] | 16,306,006 | [['G17.035', 'L01.224.050'], ['A11.251.210.190.160', 'A11.251.860.180.160', 'A11.436.140'], ['G03.143.335', 'G04.175'], ['E05.196.181.400.300'], ['G01.202', 'G02.196'], ['D02.886.675.215', 'D03.383.129.708.215'], ['D27.505.519.625.375.425.425', 'D27.505.696.577.375.425.425'], ['B01.050.150.900.649.313.988.400.112.400.4... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Male age and its association with reproductive traits in captive and wild house sparrows. | Evolutionary theory predicts that females seek extra-pair fertilizations from high-quality males. In socially monogamous bird species, it is often old males that are most successful in extra-pair fertilizations. Adaptive models of female extra-pair mate choice suggest that old males may produce offspring of higher gene... | ['Age Factors', 'Animals', 'Animals, Wild', 'Cloaca', 'England', 'Female', 'Male', 'Sparrows', 'Sperm Count', 'Spermatozoa'] | 31,529,748 | [['N05.715.350.075', 'N06.850.490.250'], ['B01.050'], ['B01.050.050.300'], ['A13.223', 'A16.178'], ['Z01.542.363.300'], ['B01.050.150.900.248.620.750.700'], ['E01.370.225.500.195.870', 'E01.370.225.992.624', 'E05.200.500.195.870', 'E05.200.992.624', 'E05.242.195.870', 'G04.140.870'], ['A05.360.490.890', 'A11.497.760']] | ['Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Determination of aortic pulse wave velocity from waveform decomposition of the central aortic pressure pulse. | Aortic pulse wave velocity (PWV), calculated from pulse transit time (PTT) using 2 separate pulse recordings over a known distance, is a significant biomarker of cardiovascular risk. This study evaluates a novel method of determining PTT from waveform decomposition of central aortic pressure using a single pulse measur... | ['Adult', 'Aged', 'Aorta', 'Blood Flow Velocity', 'Blood Pressure', 'Cohort Studies', 'Female', 'Femoral Artery', 'Humans', 'Male', 'Middle Aged', 'Models, Cardiovascular', 'Pulse'] | 18,172,062 | [['M01.060.116'], ['M01.060.116.100'], ['A07.015.114.056'], ['E01.370.370.130', 'G09.330.380.630.080'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['A07.015.114.351'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Filtration of activated granulocytes during cardiopulmonary bypass surgery: a morphologic and immunologic study to characterize the trapped leukocytes. | Cardiopulmonary bypass surgery induces an inflammatory reaction among others by activation of granulocytes. Leukocyte filtration has been shown to reduce the postoperative morbidity mediated by activated granulocytes. However, little is known about the mechanism of filter-leukocyte interaction. This study examines whet... | ['Aged', 'CD2 Antigens', 'Cardiopulmonary Bypass', 'Cell Separation', 'Female', 'Filtration', 'Granulocytes', 'Humans', 'Leukocyte Common Antigens', 'Leukocyte Count', 'Macrophage-1 Antigen', 'Male', 'Microscopy, Electron, Scanning', 'Middle Aged'] | 10,711,862 | [['M01.060.116.100'], ['D23.050.301.264.894.090', 'D23.101.100.894.090'], ['E04.292.413'], ['E01.370.225.500.363', 'E05.200.500.363', 'E05.242.363'], ['E05.196.454', 'G01.280', 'G02.263'], ['A11.118.637.415', 'A11.148.350', 'A11.627.340', 'A15.145.229.637.415', 'A15.378.316.340', 'A15.382.490.315'], ['B01.050.150.900.6... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Effectiveness of an educational and physical programme in reducing headache, neck and shoulder pain: a workplace controlled trial. | This study was an 8-month controlled trial to evaluate the effectiveness of a workplace educational and physical programme in reducing headache and neck and shoulder pain. Central registry office employees (n = 192; study group) and 192 peripheral registry office and central tax office employees (controls) in the city ... | ['Adult', 'Comorbidity', 'Female', 'Headache', 'Humans', 'Italy', 'Male', 'Middle Aged', 'Neck Pain', 'Occupational Diseases', 'Occupational Therapy', 'Patient Education as Topic', 'Physical Therapy Modalities', 'Prevalence', 'Shoulder Pain', 'Treatment Outcome'] | 18,318,746 | [['M01.060.116'], ['N05.715.350.225', 'N06.850.490.687'], ['C23.888.592.612.441'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.542.489'], ['M01.060.116.630'], ['C23.888.592.612.553'], ['C24'], ['E02.760.169.063.500.489', 'E02.831.489', 'H02.010.500'], ['I02.233.332.500', 'N02.421.726.407.680'], ['E02.779', '... | ['Named Groups [M]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Psychiatry and Psychology [F]', 'Phenomena and Process... | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Prospective evaluation of quality of life in prostate cancer patients receiving combined treatment of postoperative radiotherapy plus androgen suppression for PT3 or positive resection margin after radical prostatectomy. | OBJECTIVES: To examine the effect of postoperative radiotherapy (RT) plus 2-yr androgen suppression (AS) on quality of life (QOL) in patients with pathologic T3 or positive resection margins after radical prostatectomy (RP).METHODS: Seventy-eight patients underwent postoperative RT followed by 2-yr AS, in a phase 2 stu... | ['Aged', 'Androgen Antagonists', 'Combined Modality Therapy', 'Humans', 'Male', 'Middle Aged', 'Prospective Studies', 'Prostatectomy', 'Prostatic Neoplasms', 'Quality of Life'] | 17,140,722 | [['M01.060.116.100'], ['D06.347.065', 'D27.505.696.399.450.065'], ['E02.186'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['E04.950.774.860.625'], ['C04.588.945.440.770', 'C12.294.260.750', 'C12.294.565... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Altered white matter connectivity in young people exposed to childhood abuse: a tract-based spatial statistics (TBSS) and tractography study | Background: Childhood abuse is associated with structural brain abnormalities. Few studies have investigated white matter tract abnormalities in medication-naive, drug-free individuals who experienced childhood abuse. We examined the association between childhood abuse and abnormalities in white matter tracts in that p... | ['Adolescent', 'Cerebral Cortex', 'Child', 'Child Abuse', 'Diffusion Tensor Imaging', 'Female', 'Humans', 'Male', 'Nerve Net', 'Neural Pathways', 'White Matter'] | 30,964,614 | [['M01.060.057'], ['A08.186.211.200.885.287.500'], ['M01.060.406'], ['I01.198.240.856.350.250', 'I01.880.735.900.350.250'], ['E01.370.350.578.750', 'E01.370.350.825.500.150.500', 'E01.370.376.537.500', 'E05.629.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A08.511'], ['A08.612'], ['A08.186.211.204', 'A08.18... | ['Named Groups [M]', 'Anatomy [A]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Comparison of bleeding in patients with nonvalvular atrial fibrillation treated with ximelagatran or warfarin: assessment of incidence, case-fatality rate, time course and sites of bleeding, and risk factors for bleeding. | BACKGROUND: Ximelagatran is a novel direct thrombin inhibitor that can be administered as a fixed oral dose, without the need for anticoagulant monitoring.METHODS: We undertook a pooled analysis of 7329 patients with nonvalvular atrial fibrillation from the Stroke Prevention Using Oral Thrombin Inhibitor in Atrial Fibr... | ['Adolescent', 'Adult', 'Aged', 'Anticoagulants', 'Atrial Fibrillation', 'Azetidines', 'Benzylamines', 'Female', 'Follow-Up Studies', 'Hemorrhage', 'Humans', 'Incidence', 'Male', 'Middle Aged', 'Risk Factors', 'Survival Rate', 'Thrombosis', 'Time Factors', 'Treatment Outcome', 'Warfarin'] | 16,636,210 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.502.119'], ['C14.280.067.198', 'C23.550.073.198'], ['D03.383.082.301'], ['D02.092.200', 'D02.455.426.559.389.140.210'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['C23.550.414'], ['B01.050.150.900.649.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Polymer coatings that display specific biological signals while preventing nonspecific interactions. | Control over cell-material surface interactions is the key to many new and improved biomedical devices. It can only be achieved if interactions that are mediated by nonspecifically adsorbed serum proteins are minimized and if cells instead respond to specific ligand molecules presented on the surface. Here, we present ... | ['Cell Adhesion', 'Cell Communication', 'Chromatography, Gel', 'Coated Materials, Biocompatible', 'Esters', 'HeLa Cells', 'Humans', 'Hydrolysis', 'Methacrylates', 'Photoelectron Spectroscopy', 'Polyethylene Glycols', 'Polymerization', 'Polymers', 'Proton Magnetic Resonance Spectroscopy', 'Succinimides'] | 22,076,848 | [['G04.022'], ['G04.085'], ['E05.196.181.400.250'], ['D25.130.420', 'J01.637.051.130.420'], ['D02.241.400'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.380'], ['D02.241.081.069.600'], ['E05.196.867.618'], ['D02.033.455.250.700', 'D05.750.741', '... | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Treatment of effluents of poultry slaughterhouse with aluminum salts and natural polyelectrolytes. | A mixture of aluminum salts and natural polyelectrolytes, extracted from the cactus Opuntia ficus indica, has been used for cleaning of wastewater from poultry slaughterhouse. The aggregation and settling properties of colloids and complex organics such as oil, grease, fats, proteins, and suspended solids, was increase... | ['Abattoirs', 'Alum Compounds', 'Animals', 'Electrolytes', 'Emulsions', 'Flocculation', 'Industrial Waste', 'Poultry', 'Waste Disposal, Fluid'] | 12,211,454 | [['J01.576.423.200.700.100', 'J03.540.020'], ['D01.056.025', 'D01.875.800.800.850.025'], ['B01.050'], ['D01.248'], ['D20.280.260', 'D26.255.165.260'], ['E05.196.150.347', 'G02.159.347'], ['D20.944.420', 'N06.850.460.710.420'], ['B01.050.050.116.625', 'B01.050.150.900.248.690', 'G07.203.300.600.750', 'J02.500.600.750'],... | ['Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
The relation between the rod-like inner structures and the shapes of the cells. | The shapes of the cells with simple rod-like inner structures are studied theoretically. Since the cell with inner structure can be bent, the possibility of non-axisymmetric shapes is considered. The equilibrium shape of the cell, obtained by minimizing the sum of the membrane bending energy and the bending energy of t... | ['Cell Size', 'Cells', 'Models, Biological'] | 10,653,167 | [['G04.325'], ['A11'], ['E05.599.395']] | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The evaluation of novel mixed metal hydroxy-carbonates as phosphate binders: an in-vivo study in the rat. | A number of novel phosphate binders based on mixed metal hydroxide structures incorporating Fe and Ca, or Fe and Mg (classified as CT, Crosfield test compounds), were compared with the established phosphate binders Mg(OH)2, Al(OH)3, CaCO3 and a commercial hydrotalcite (Al- and Mg-based) using a rat model. The changes i... | ['Animals', 'Carbonates', 'Hydroxides', 'Iron', 'Metals', 'Phosphates', 'Rats', 'Rats, Sprague-Dawley'] | 11,341,368 | [['B01.050'], ['D01.045.125', 'D01.200.275.150', 'D01.248.497.158.165'], ['D01.045.250', 'D01.248.497.158.459'], ['D01.268.556.412', 'D01.268.956.287', 'D01.552.544.412'], ['D01.552'], ['D01.029.260.700.675.374', 'D01.248.497.158.730', 'D01.695.625.675.650'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.9... | ['Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Lactoferrin increases the output of neutrophil precursors and attenuates the spontaneous production of TNF-alpha and IL-6 by peripheral blood cells. | The aim of this report was to investigate the effects of bovine lactoferrin (BLF) taken orally (per os) by healthy individuals, on selected immune parameters. Three groups of volunteers (7 persons per group) were taken daily for 7 days, one capsule containing 2, 10 or 50 mg of BLF. A control group has taken placebo onl... | ['Adjuvants, Immunologic', 'Administration, Oral', 'Adult', 'Animals', 'Cattle', 'Cells, Cultured', 'Dose-Response Relationship, Immunologic', 'Female', 'Hematopoietic Stem Cells', 'Humans', 'Interleukin-6', 'Lactoferrin', 'Leukocyte Count', 'Male', 'Middle Aged', 'Neutrophils', 'Tumor Necrosis Factor-alpha'] | 10,202,564 | [['D27.505.696.477.067'], ['E02.319.267.100'], ['M01.060.116'], ['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['A11.251'], ['G12.300'], ['A11.148.378', 'A11.872.378', 'A15.378.316.378'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.465.224', 'D12.776.467.374.465.202', 'D23.529.374.465.224'... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Cytotoxicity of cancer patient's macrophages for tumor cells. | Monocyte derived macrophages were isolated from the peripheral blood of 66 patients with either breast, colon, gynecological or hematological cancers. The macrophages from the breast and gynecologic cancer patients generally did not acquire enhanced cytotoxicity for human tumor cells after incubation with bacterial lip... | ['Adenocarcinoma', 'Breast Neoplasms', 'Cell Adhesion', 'Cell Line', 'Colonic Neoplasms', 'Cytotoxicity, Immunologic', 'Female', 'Genital Neoplasms, Female', 'Hematologic Diseases', 'Humans', 'Macrophages', 'Male', 'Multiple Myeloma', 'Neoplasms'] | 7,093,892 | [['C04.557.470.200.025'], ['C04.588.180', 'C17.800.090.500'], ['G04.022'], ['A11.251.210'], ['C04.588.274.476.411.307.180', 'C06.301.371.411.307.180', 'C06.405.249.411.307.180', 'C06.405.469.158.356.180', 'C06.405.469.491.307.180'], ['G12.287'], ['C04.588.945.418', 'C13.351.937.418'], ['C15.378'], ['B01.050.150.900.649... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Risk of occupational glass injury in bar staff. | One hundred and twenty-six bar staff (median length of service 2.7 years) working in 42 randomly selected public houses in South Glamorgan were interviewed and examined in the workplace to investigate the incidence, characteristics and treatment of lacerations from bar glassware. 41 per cent reported previous injury, 1... | ['Accidents, Occupational', 'Adult', 'Drinking', 'Female', 'Glass', 'Hand Injuries', 'Humans', 'Incidence', 'Male', 'Random Allocation', 'Risk Factors', 'Wales', 'Wounds, Penetrating'] | 8,206,650 | [['N06.850.135.240'], ['M01.060.116'], ['G07.203.650.283.249', 'G10.261.330.249'], ['J01.637.437'], ['C26.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.985.525.375'], ['E05.318.370.700', 'E05.581.500.805', 'N05.... | ['Health Care [N]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
An interdependent metabolic patchwork in the nested symbiosis of mealybugs. | Highly reduced genomes of 144-416 kilobases have been described from nutrient-provisioning bacterial symbionts of several insect lineages [1-5]. Some host insects have formed stable associations with pairs of bacterial symbionts that live in specialized cells and provide them with essential nutrients; genomic data from... | ['Animals', 'Betaproteobacteria', 'Gammaproteobacteria', 'Gene Expression', 'Genome, Bacterial', 'Hemiptera', 'Metabolic Networks and Pathways', 'Molecular Sequence Data', 'Symbiosis'] | 21,835,622 | [['B01.050'], ['B03.660.075'], ['B03.660.250'], ['G05.297'], ['G05.360.340.358.207'], ['B01.050.500.131.617.412'], ['G03.493'], ['L01.453.245.667'], ['G06.550.800', 'G16.840']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Oxidation of butylated hydroxytoluene to toxic metabolites. Factors influencing hydroxylation and quinone methide formation by hepatic and pulmonary microsomes. | The effects of inducing agents and inhibitors on the cytochrome P-450-catalyzed oxidations of butylated hydroxytoluene (BHT) to form three metabolites were investigated with liver and lung microsomes from rats and mice. These compounds, the quinone methide (QM) formed by two-electron oxidation of BHT, the hydroxy-tert-... | ['Animals', 'Butylated Hydroxytoluene', 'Cytochrome P-450 Enzyme Inhibitors', 'Hydroxylation', 'Indolequinones', 'Indoles', 'Lung', 'Male', 'Metyrapone', 'Mice', 'Mice, Inbred A', 'Mice, Inbred DBA', 'Mice, Inbred Strains', 'Microsomes', 'Microsomes, Liver', 'Oxidation-Reduction', 'Phenobarbital', 'Proadifen', 'Quinone... | 1,676,656 | [['B01.050'], ['D02.455.426.559.389.657.239.216'], ['D27.505.389.500', 'D27.505.519.389.335'], ['G02.111.385', 'G02.607.348', 'G03.425'], ['D02.806.400', 'D03.633.100.473.412'], ['D03.633.100.473'], ['A04.411'], ['D03.383.725.463'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.300', 'B01.050.1... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The small GTP-binding proteins Rab4 and ARF are associated with released exosomes during reticulocyte maturation. | During maturation of reticulocytes to erythrocytes, small vesicles, termed exosomes, are released into the extracellular medium. GTP-binding proteins associated with exosomes were identified by separating proteins by sodium dodecyl sulfate polyacrylamide gel electrophoresis, transferring the proteins to nitrocellulose,... | ['ADP-Ribosylation Factors', 'Animals', 'Cell Differentiation', 'Erythrocytes', 'Exocytosis', 'GTP-Binding Proteins', 'Molecular Weight', 'Rats', 'Rats, Sprague-Dawley', 'Reticulocytes', 'Trypsin', 'rab4 GTP-Binding Proteins'] | 8,330,623 | [['D08.811.277.040.330.300.400.100', 'D12.644.360.525.100', 'D12.776.157.325.515.100', 'D12.776.476.525.100'], ['B01.050'], ['G04.152'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['G04.468'], ['D08.811.277.040.330.300', 'D12.776.157.325'], ['G02.494'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Correlating dynamics and selectivity in adsorption of semiconductor nanocrystals onto a self-organized pattern. | Selective adsorption of semiconductor nanocrystals onto an organic self-organized pattern shows a time-dependent behavior. By studying the wetting behavior of delivered solvent (1-phenyloctane) on a lipid self-organized pattern and determining the adhesion energy between semiconductor nanocrystals and substrate, we obt... | ['1,2-Dipalmitoylphosphatidylcholine', 'Adsorption', 'Benzene Derivatives', 'Crystallization', 'Lipids', 'Microscopy, Atomic Force', 'Molecular Conformation', 'Nanoparticles', 'Nanotechnology', 'Quantum Dots', 'Semiconductors', 'Solvents', 'Substrate Specificity', 'Time Factors'] | 17,914,855 | [['D10.570.755.375.760.400.800.224'], ['G01.030', 'G02.020'], ['D02.455.426.559.389'], ['E05.196.300', 'G02.171'], ['D10'], ['E01.370.350.515.666.400', 'E05.595.666.400'], ['G02.111.570.820'], ['J01.637.512.600'], ['H01.603', 'J01.897.520.600'], ['E07.705', 'J01.637.512.600.650'], ['E07.305.625'], ['D27.720.844'], ['G0... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Optical properties of diatom nanostructured biosilica in Arachnoidiscus sp: micro-optics from mother nature. | Some natural structures show three-dimensional morphologies on the micro- and nano-scale, characterized by levels of symmetry and complexity well far beyond those fabricated by best technologies available. This is the case of diatoms, unicellular microalgae, whose protoplasm is enclosed in a nanoporous microshell, made... | ['Diatoms', 'Light', 'Nanostructures', 'Silicon Dioxide'] | 25,076,045 | [['B01.750.200'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['J01.637.512'], ['D01.578.750', 'D01.650.550.825', 'D01.837.725']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
The Escherichia coli unc transcription terminator enhances expression of uncC, encoding the epsilon subunit of F1-ATPase, from plasmids by stabilizing the transcript. | The effect of the unc transcription terminator on expression of uncC, encoding the epsilon subunit of Escherichia coli F1-ATPase, from plasmids was studied. The cloned sequence in pTK1 included the uncC ribosome binding site, the uncC structural gene, and the unc transcription terminator. The cloned region in pSD37 was... | ['Blotting, Northern', 'Escherichia coli', 'Gene Expression Regulation, Bacterial', 'Kinetics', 'Macromolecular Substances', 'Molecular Weight', 'Plasmids', 'Proton-Translocating ATPases', 'RNA, Messenger', 'Terminator Regions, Genetic', 'Transcription, Genetic'] | 2,150,540 | [['E05.196.401.095', 'E05.301.300.074', 'E05.601.100'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['G05.308.300'], ['G01.374.661', 'G02.111.490'], ['D05'], ['G02.494'], ['G05.360.600'], ['D08.811.277.040.025.325', 'D08.811.913.696.650.150.500', 'D12.776.157.530.450.250.875.500', 'D12.776.543.585.450.250.8... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Two different cDNAs code for L-DOPA decarboxylase in the white prepuparium and eclosion developmental stages of the insect Ceratitis capitata1. | In insects the DOPA decarboxylase gene (Ddc) is expressed in the epidermis where dopamine derivatives promote cuticle sclerotization and the central nervous system participating in the synthesis of serotonin and dopamine. The temporal course of Ddc enzyme activity during the white prepuparium and eclosion developmental... | ['Amino Acid Sequence', 'Animals', 'Base Sequence', 'Cloning, Molecular', 'DNA, Complementary', 'Diptera', 'Dopa Decarboxylase', 'Larva', 'Molecular Sequence Data', 'Protein Isoforms', 'Sequence Alignment'] | 9,838,157 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.393.220'], ['D13.444.308.497.220', 'D13.444.600.223.500', 'D27.720.470.530.600.223.260'], ['B01.050.500.131.617.720.500.500.750'], ['D08.811.520.224.125.100.500'], ['B05.500.500', 'G07.345.500.550.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Specificity of CTL interactions with peptide-MHC class I tetrameric complexes is temperature dependent. | Tetrameric peptide-MHC class I complexes ("tetramers") are proving invaluable as reagents for characterizing immune responses involving CTLs. However, because the TCR can exhibit a degree of promiscuity for binding peptide-MHC class I ligands, there is potential for cross-reactivity. Recent reports showing that the TCR... | ['Body Temperature', 'Cells, Cultured', 'Cold Temperature', 'Cytotoxicity, Immunologic', 'Epitopes, T-Lymphocyte', 'HLA-A2 Antigen', 'Humans', 'Ligands', 'Macromolecular Substances', 'Oligopeptides', 'Protein Binding', 'Staining and Labeling', 'T-Lymphocytes, Cytotoxic', 'Temperature'] | 10,510,374 | [['E01.370.600.875.374', 'G07.110'], ['A11.251'], ['G01.906.595.272', 'G16.500.275.063.725.710.300', 'G16.500.750.775.710.300', 'N06.230.300.100.725.154', 'N06.230.300.100.725.710.300'], ['G12.287'], ['D23.050.550.402'], ['D12.776.395.550.489.400.020', 'D12.776.543.550.439.400.020', 'D23.050.301.500.100.400.020', 'D23.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Delayed gametogenesis and progesterone levels in soft-shell clams (Mya arenaria) in relation to in situ contamination to organotins and heavy metals in the St. Lawrence River (Canada). | There is a growing awareness that contaminants in the aquatic environment may alter steroid hormone levels and affect the reproductive success of the invertebrates. To verify if heavy metals and organotins affect sexual maturation in Mya arenaria, individuals were collected from July to November 1998, at different site... | ['Animals', 'Bivalvia', 'Cadmium', 'Copper', 'Environmental Monitoring', 'Enzyme-Linked Immunosorbent Assay', 'Female', 'Fresh Water', 'Gametogenesis', 'Gonads', 'Lead', 'Male', 'Mercury', 'Metals, Heavy', 'Organotin Compounds', 'Progesterone', 'Quebec', 'Sex Ratio', 'Water Pollutants, Chemical', 'Zinc'] | 12,860,053 | [['B01.050'], ['B01.050.500.644.080'], ['D01.268.556.137', 'D01.268.956.061', 'D01.552.544.137'], ['D01.268.556.195', 'D01.268.956.170', 'D01.552.544.195'], ['N06.850.460.350.080', 'N06.850.780.375'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Clinical profile of primary sclerosing cholangitis in Singapore. | BACKGROUND AND AIM: Primary sclerosing cholangitis (PSC) is a rare chronic disease in Singapore and its epidemiological profile has not been described previously. The present study aimed to define the demographic and clinical profile of patients with PSC in Singapore.METHODS: The case records of patients with PSC seen ... | ['Adult', 'Age Distribution', 'Cholangitis, Sclerosing', 'Female', 'Hospitals, General', 'Humans', 'Male', 'Middle Aged', 'Outcome Assessment, Health Care', 'Sex Distribution', 'Singapore'] | 12,164,967 | [['M01.060.116'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['C06.130.120.200.110'], ['N02.278.421.389'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['H01.770.644.145.431', 'N04.761.559.590', 'N05.715.360.575.575'], ['I01.240.800', 'N01.224.803', 'N06.850.505.400.850'], ['Z01.252... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Homeless Shelter Characteristics and Prevalence of SARS-CoV-2. | INTRODUCTION: The unfolding COVID-19 pandemic has predictably followed the familiar contours of well established socioeconomic health inequities, exposing and often amplifying preexisting disparities. People living in homeless shelters are at higher risk of infection with severe acute respiratory syndrome coronavirus 2... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Betacoronavirus', 'COVID-19', 'Coronavirus Infections', 'Cross-Sectional Studies', 'Female', 'Health Policy', 'Health Status Disparities', 'Health Surveys', 'Homeless Persons', 'Housing', 'Humans', 'Infection Control', 'Male', 'Middle Aged', 'Pandemics', 'Pneumonia,... | 32,970,553 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['B04.820.578.500.540.150.113'], ['C01.748.214', 'C01.748.610.763.500', 'C01.925.705.500', 'C01.925.782.600.550.200.163', 'C08.381.677.807.500', 'C08.730.214', 'C08.730.610.763.500'], ['C01.925.782.600.550.200'], ['E05.318.372.500.875', 'N... | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Technology, Industry, and Agriculture [J]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
Treatment of cutaneous T cell lymphoma with intermediate doses of interferon alpha 2a. | In this study we treated 6 patients with epidermotropic cutaneous T cell lymphoma (CTCL) with intermediate doses of recombinant alpha 2a interferon (18-100 x 10(6) IU/week) for 2-6 months. One patient experienced complete clinical remission in spite of a persistent dense lymphocytic skin infiltrate. One patient was mar... | ['Adult', 'Aged', 'Aged, 80 and over', 'Female', 'Humans', 'Interferon Type I', 'Lymphoma', 'Male', 'Middle Aged', 'Skin Neoplasms'] | 2,767,295 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.440.890', 'D12.776.467.374.440.890', 'D23.529.374.440.890'], ['C04.557.386', 'C15.604.515.569', 'C20.683.515.761'], ['M01.060.116.630'], ['C04.588.805', 'C17.800.882']] | ['Named Groups [M]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Prevalence of Erwinia soft rot affecting cut foliage, Dracaena sanderiana ornamental industry and solution towards its management. | The study was carried out under net house conditions at Green Farms Ltd, Marawila to determine the occurrence and severity of Erwinia soft rot disease in Dracaena sanderiana plants and to formulate the possible control measures. Field experiment was carried out to manage the soft rot disease in D. sanderiana plants. Th... | ['Agriculture', 'Dracaena', 'Erwinia', 'Plant Diseases', 'Soil'] | 23,878,983 | [['J01.040'], ['B01.650.940.800.575.912.250.618.100.060.250'], ['B03.440.450.425.300', 'B03.660.250.150.175'], ['G15.610'], ['D20.721', 'G01.311.820', 'G16.500.275.815', 'N06.230.600']] | ['Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
[HCG-positive cells in seminoma of the testis]. | In a retrospective study of 38 patients with pure seminoma, serum and urine levels of human chorionic gonadotropin (HCG) were measured and the cellular origin of HCG-like substance was searched using the technique of indirect immunoperoxidase on step sections of the tumors. Eight of the patients had elevated HCG in ser... | ['Adult', 'Aged', 'Chorionic Gonadotropin', 'Chorionic Gonadotropin, beta Subunit, Human', 'Dysgerminoma', 'Humans', 'Immunoenzyme Techniques', 'Male', 'Middle Aged', 'Neoplasm Staging', 'Peptide Fragments', 'Prognosis', 'Testicular Neoplasms'] | 6,204,519 | [['M01.060.116'], ['M01.060.116.100'], ['D06.472.699.322.326', 'D06.472.699.649.367', 'D12.644.548.726.367', 'D12.776.780.400'], ['D06.472.699.322.326.125', 'D06.472.699.649.367.125', 'D12.644.548.726.367.125', 'D12.776.780.400.125', 'D23.101.140.325', 'D23.101.175'], ['C04.557.465.330.300'], ['B01.050.150.900.649.313.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
On-line counting of cysteine residues in peptides during electrospray ionization by electrogenerated tags and their application to protein identification. | The electrochemically induced mass spectrometric tagging of cysteines by substituted hydroquinones was studied for peptides in a classical electrospray solvent (i.e., MeOH/H2O/AcOH 50/49/1). The tagging efficiency was tested with different hydroquinone compounds on an undecapeptide containing one cysteine residue. 2-ca... | ['Animals', 'Cattle', 'Cysteine', 'Humans', 'Lactalbumin', 'Online Systems', 'Peptide Mapping', 'Peptides', 'Proteins', 'Serum Albumin, Bovine', 'Spectrometry, Mass, Electrospray Ionization', 'Staining and Labeling'] | 15,624,160 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['D02.886.030.230', 'D02.886.489.155', 'D12.125.154.299', 'D12.125.166.230'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.034.398', 'D12.776.256.159.750.816.250'], ['L01.313.500.750.300.742'], ['E05.196.181.400.454.720', 'E05.196.401.319.720', 'E05.1... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Farnesol is utilized for protein isoprenylation and the biosynthesis of cholesterol in mammalian cells. | Evidence has been obtained indicating that free farnesol (F-OH) can be utilized for isoprenoid biosynthesis in mammalian cells. When rat C6 glial cells and an African green monkey kidney cell line (CV-1) were incubated with [3H]F-OH, radioactivity was incorporated into cholesterol, ubiquinone (CoQ) and isoprenylated pr... | ['Animals', 'Cell Line', 'Chlorocebus aethiops', 'Cholesterol', 'Cysteine', 'Diterpenes', 'Electrophoresis, Polyacrylamide Gel', 'Farnesol', 'Glioma', 'Kinetics', 'Mevalonic Acid', 'Neoplasm Proteins', 'Protein Biosynthesis', 'Protein Prenylation', 'Proteins', 'Rats', 'Tritium', 'Tumor Cells, Cultured', 'Ubiquinone'] | 7,794,274 | [['B01.050'], ['A11.251.210'], ['B01.050.150.900.649.313.988.400.112.199.120.126.110'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['D02.886.030.230', 'D02.886.489.155', 'D12.125.154.299', 'D12.125.166.230'], ['D02.455.849.291'], ['E05.196.401.402', 'E05.301.300.319'], ['D02.033.415.400'... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Chromatin structure and factor site occupancies in an in vivo-assembled transcription elongation complex. | The chromatin structure specific to the SV40 late transcription elongation complex as well as the occupancy of several sites that bind transcription factors have been examined. These features have been determined by assessing blockage to restriction enzyme digestion. Cleavage specific to the elongation complex has been... | ['Ammonium Sulfate', 'Cells, Cultured', 'Centrifugation, Density Gradient', 'Chromatin', 'Chromosomes', 'DNA Restriction Enzymes', 'DNA, Viral', 'Electrophoresis, Agar Gel', 'Gene Expression Regulation, Viral', 'Kinetics', 'Nucleosomes', 'Osmolar Concentration', 'RNA, Messenger', 'Restriction Mapping', 'Simian virus 40... | 8,918,788 | [['D01.625.062.374', 'D01.875.800.800.850.050'], ['A11.251'], ['E05.181.724.336', 'E05.196.941.336'], ['A11.284.430.106.279.345.190.160.180', 'D12.776.664.224', 'G05.360.160.180'], ['A11.284.187', 'A11.284.430.106.279.345.190', 'G05.360.162'], ['D08.811.150.280', 'D08.811.277.352.335.350.300', 'D08.811.277.352.355.325.... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Application of hydrogen peroxide for the removal of toxic cyanobacteria and other phytoplankton from wastewater. | Phytoplankton blooms containing elevated levels of cyanobacteria are common in wastewatertreatment plants. Microcystis aeruginosa, the most common freshwater cyanobacterial species, produces the hepatotoxin microcystin, which is a threat to human and environmental health. Blooms also affect the viability of treating an... | ['Chlorophyll', 'Chlorophyll A', 'Cyanobacteria', 'Environmental Restoration and Remediation', 'Hydrogen Peroxide', 'Kinetics', 'Phytoplankton', 'Waste Disposal, Fluid', 'Water Purification'] | 19,192,818 | [['D03.383.129.578.840.374', 'D03.633.400.909.374', 'D04.345.783.374'], ['D03.383.129.578.840.374.140', 'D03.633.400.909.374.140', 'D04.345.783.374.140'], ['B03.280', 'B03.440.475.100'], ['N06.230.080.600', 'N06.850.460.375'], ['D01.248.497.158.685.750.424', 'D01.339.431.374.424', 'D01.650.550.750.400', 'D02.389.338.25... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Improvement of a low pH antigen-antibody dissociation procedure for ELISA measurement of circulating anti-Abeta antibodies. | BACKGROUND: Prior work from our group found that acid dissociation (pH 2.5 incubation) of serum from APP transgenic mice vaccinated against Abeta increased the apparent anti-Abeta titers, suggesting antibody masking by antigen in the ELISA assay. Subsequently, we found that pH 2.5 incubation of serum from unvaccinated ... | ['Amyloid beta-Peptides', 'Animals', 'Antigen-Antibody Complex', 'Autoantibodies', 'Enzyme-Linked Immunosorbent Assay', 'Hydrogen-Ion Concentration', 'Mice', 'Mice, Transgenic', 'Peptide Fragments', 'Reproducibility of Results', 'Sensitivity and Specificity'] | 17,374,155 | [['D12.644.024', 'D12.776.049.407.249.500', 'D12.776.543.039.500'], ['B01.050'], ['D12.776.124.486.485.114.257', 'D12.776.124.790.651.114.257', 'D12.776.377.715.548.114.257', 'D23.050.101'], ['D12.776.124.486.485.114.323', 'D12.776.124.790.651.114.323', 'D12.776.377.715.548.114.323'], ['E05.478.566.350.170', 'E05.478.5... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Phenolic components rich ethyl acetate fraction of Orostachys japonicus inhibits lipid accumulation by regulating reactive oxygen species generation in adipogenesis. | In this study, Orostachys japonicus was extracted with ethyl alcohol and fractionated by a serial of organic solvents. The ethyl acetate fraction was found to be the most effective among the tested five fractions. High-performance liquid chromatography and mass spectrometry analysis of the ethyl acetate fraction presen... | ['3T3-L1 Cells', 'Acetates', 'Adipogenesis', 'Animals', 'Cell Differentiation', 'Cell Survival', 'Crassulaceae', 'Free Radical Scavengers', 'Gene Expression Regulation, Enzymologic', 'Lipid Metabolism', 'Mice', 'Oxygen Radical Absorbance Capacity', 'Phenols', 'Plant Extracts', 'Reactive Oxygen Species'] | 31,368,568 | [['A11.251.210.100.775.800', 'A11.329.228.100.775.800'], ['D02.241.081.018', 'D10.251.400.045'], ['G04.152.149'], ['B01.050'], ['G04.152'], ['G04.346'], ['B01.650.940.800.575.912.250.859.937.249'], ['D27.505.519.217.500'], ['G05.308.320'], ['G03.458'], ['B01.050.150.900.649.313.992.635.505.500'], ['E05.657'], ['D02.455... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Human regulatory T cells are targets for human immunodeficiency Virus (HIV) infection, and their susceptibility differs depending on the HIV type 1 strain. | Regulatory T cells (Treg) are a subpopulation of CD4(+) T cells characterized by the suppressive activity they exert on effector immune responses, including human immunodeficiency virus (HIV)-specific immune responses. Because Treg express CXCR4 and CCR5, they represent potential targets for HIV; however, Treg suscepti... | ['DNA, Viral', 'Enzyme-Linked Immunosorbent Assay', 'Flow Cytometry', 'HIV Core Protein p24', 'HIV-1', 'Humans', 'Lymphocyte Activation', 'Receptors, CCR5', 'Receptors, CXCR4', 'T-Lymphocytes, Regulatory', 'Virus Replication'] | 19,828,616 | [['D13.444.308.568'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.200.500.386.350', 'E05.242.363.342', 'E05.242.386.350'], ['D12.776.... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
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