Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Effect of recombinant IL 2 and gamma-IFN on proliferation and differentiation of human B cells. | The effects of IL 2 and gamma-IFN on the activation of human B cells was studied with recombinant IL 2 and gamma-IFN. BCDF-responsive B lymphoblastoid cell lines and highly purified human B cells were employed as target B cells. IL 2 or gamma-IFN did not induce any IgG or IgM secretion in the B cell lines CESS and SKW6... | ['Animals', 'Antibodies, Anti-Idiotypic', 'Antibody-Producing Cells', 'Antigens, Surface', 'B-Lymphocytes', 'Cell Differentiation', 'Cell Line', 'Humans', 'Interferon-gamma', 'Interleukin-2', 'Lymphocyte Activation', 'Mice', 'Staphylococcal Protein A', 'Tumor Necrosis Factor Receptor Superfamily, Member 7'] | 2,981,272 | [['B01.050'], ['D12.776.124.486.485.114.071', 'D12.776.124.790.651.114.071', 'D12.776.377.715.548.114.071'], ['A11.063', 'A15.382.032'], ['D23.050.301'], ['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['G04.152'], ['A11.251.210'], ['B01.050.150.9... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Distribution and inhibition of neutral metalloendopeptidase (NEP) (EC 3.4.24.11), the major degradative enzyme for atrial natriuretic peptide, in the rat kidney. | 1. Atrial natriuretic peptide (ANP) is degraded by neutral metalloendopeptidase (NEP) (EC 3.4.24.11) and the kidney is a major site of ANP clearance. 2. The regional distribution of NEP in the rat kidney was investigated. 3. The activity of NEP, measured with an enzymatic fluorimetric method employing N-dansyl-D-alanyl... | ['Animals', 'Atrial Natriuretic Factor', 'Dansyl Compounds', 'Fluorescence', 'Kidney', 'Male', 'Metalloendopeptidases', 'Oligopeptides', 'Rats', 'Rats, Inbred Strains', 'Tissue Distribution'] | 1,833,101 | [['B01.050'], ['D06.472.699.584.500', 'D12.644.548.585.500'], ['D02.455.426.559.847.638.204', 'D02.886.590.192', 'D04.615.638.204'], ['G01.358.500.505.650.665.500', 'G01.590.540.665.500'], ['A05.810.453'], ['D08.811.277.656.300.480', 'D08.811.277.656.675.374'], ['D12.644.456'], ['B01.050.150.900.649.313.992.635.505.700... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Congenital anomalies at the craniovertebral junction-posterior fossa region: report of two cases. | BACKGROUND: Various combinations of bony and soft tissue anomalies have been described at the craniovertebral junction (CVJ). These include posterior fossa dermoids (with or without dermal sinuses) associated with Klippel-Feil anomalies and dermoids (no previous reports of overlying dermal sinuses) associated with bony... | ['Adult', 'Atlanto-Occipital Joint', 'Cranial Fossa, Posterior', 'Dermoid Cyst', 'Female', 'Headache', 'Humans', 'Klippel-Feil Syndrome', 'Magnetic Resonance Imaging', 'Male', 'Neck Pain', 'Quadriplegia', 'Scoliosis', 'Tomography, X-Ray Computed', 'Urination Disorders'] | 23,959,613 | [['M01.060.116'], ['A02.835.583.101'], ['A01.456.830.200', 'A02.835.232.781.750.400'], ['C04.182.201', 'C04.557.465.910.250'], ['C23.888.592.612.441'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C05.116.099.370.535', 'C05.660.551', 'C16.131.621.551'], ['E01.370.350.825.500'], ['C23.888.592.612.553'], ['C10.597.... | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Subject-specific profiles of QT/RR hysteresis. | The time lag of the QT interval adaptation to heart rate changes (QT/RR hysteresis) was studied in 40 healthy subjects (18 females; mean age, 30.4+/-8.1 yr) with 3 separate daytime (>13 h) 12-lead electrocardiograms (ECG) in each subject. In each recording, 330 individual 10-s ECG segments were measured, including 100 ... | ['Action Potentials', 'Adaptation, Physiological', 'Adult', 'Electrocardiography', 'Female', 'Heart Conduction System', 'Heart Rate', 'Humans', 'Male', 'Middle Aged', 'Models, Cardiovascular', 'Reproducibility of Results', 'Time Factors', 'Young Adult'] | 18,849,333 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['G07.025', 'G16.012.500'], ['M01.060.116'], ['E01.370.370.380.240', 'E01.370.405.240'], ['A07.541.409'], ['E01.370.600.875.500', 'G09.330.380.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.599.395.161'], ['E05.318.370.725', 'E0... | ['Phenomena and Processes [G]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Is there variation in crossover interference levels among chromosomes from human males? | We demonstrate that recent data from human males are consistent with constant interference levels among chromosomes under the two-pathway model, whereas inappropriately fitting shape parameters of Gamma distributions to immunofluorescent interfoci distances observed on finite chromosomes generates false interpretations... | ['Chromosome Mapping', 'Chromosomes, Human', 'Crossing Over, Genetic', 'Genetic Variation', 'Genome, Human', 'Humans', 'Male', 'Meiosis', 'Sex Factors', 'Statistical Distributions'] | 19,581,450 | [['E05.393.183'], ['A11.284.187.520.300', 'G05.360.162.520.300'], ['G05.728.615.200'], ['G05.365'], ['G05.360.340.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G04.144.220.220.687', 'G05.113.220.687'], ['N05.715.350.675', 'N06.850.490.875'], ['E05.318.740.994', 'G17.820', 'N05.715.360.750.750', 'N06.850.520... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[Experience in the use of anti-colibacillus and Proteus lactoglobulin as a supplement to milk products in diet therapy at a specialized childrens' collective]. | A new biologically active supplement (BAS) for infant food was tested at an Infant's Home. BAS-IG contains lactoglobulin, an immune preparation against colibacillus and Proteus. During the primary examination of the infants in the Infant's Home intestinal dysbacteriosis was revealed in 100% of the infants, clinical sig... | ['Child Day Care Centers', 'Child, Preschool', 'Diarrhea', 'Enterobacteriaceae Infections', 'Humans', 'Infant', 'Lactoglobulins', 'Proteus Infections'] | 2,718,415 | [['J03.160', 'N02.421.143.098'], ['M01.060.406.448'], ['C23.888.821.214'], ['C01.150.252.400.310'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['D12.776.256.159.750.816.500', 'D12.776.377.457'], ['C01.150.252.400.310.708']] | ['Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Nifedipine has paradoxical effects on the development of kindling but not on kindled seizures in amygdala-kindled rats. | The effects of nifedipine, an antagonist of voltage-operated calcium channels, on the development of amygdala kindling and on the production of fully kindled seizures, stimulated from the amygdala, were investigated. Rats were treated daily with two doses (5 and 50 mg/kg, i.p.) of nifedipine during the development of k... | ['Action Potentials', 'Amygdala', 'Analysis of Variance', 'Animals', 'Kindling, Neurologic', 'Male', 'Nifedipine', 'Rats', 'Rats, Inbred Strains', 'Reaction Time'] | 1,865,996 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['A08.186.211.180.090', 'A08.186.211.200.885.287.249.152'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['B01.050'], ['G11.561.484'], ['D03.383.725.203.540'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760', 'B01.050.... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Modeling, synthesis, and biological evaluation of potential retinoid X receptor (RXR) selective agonists: novel analogues of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene) and (E)-3-(3-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)-4-hydroxyphenyl)acrylic acid (CD... | Three unreported analogues of 4-[1-(3,5,5,8,8-pentamethyl-5-6-7-8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (1), otherwise known as bexarotene, as well as four novel analogues of (E)-3-(3-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)-4-hydroxyphenyl)acrylic acid (CD3254), are described and evaluated for th... | ['Coumaric Acids', 'Crystallography, X-Ray', 'Dose-Response Relationship, Drug', 'Humans', 'Models, Molecular', 'Molecular Structure', 'Retinoid X Receptors', 'Structure-Activity Relationship', 'Tetrahydronaphthalenes'] | 24,180,745 | [['D02.241.223.200.210'], ['E05.196.309.742.225'], ['G07.690.773.875', 'G07.690.936.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.595'], ['G02.111.570', 'G02.466'], ['D12.776.826.701.500', 'D12.776.930.775.500'], ['G02.111.830', 'G07.690.773.997'], ['D02.455.426.559.847.638.960', 'D04.615.638.960']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Performance of heterogeneous ZrO2 supported metaloxide catalysts for brown grease esterification and sulfur removal. | In order to achieve a viable biodiesel industry, new catalyst technology is needed which can process a variety of less expensive waste oils, such as yellow grease and brown grease. However, for these catalysts to be effective for biodiesel production using these feedstocks, they must be able to tolerate higher concentr... | ['Biofuels', 'Catalysis', 'Esterification', 'Fatty Acids, Nonesterified', 'Industrial Oils', 'Sulfur', 'Zirconium'] | 21,078,551 | [['D20.147', 'N06.230.132.644.124'], ['G02.130'], ['G02.111.270', 'G02.607.250', 'G03.344'], ['D10.251.310'], ['J01.637.450'], ['D01.268.185.900'], ['D01.268.556.950', 'D01.268.956.937', 'D01.552.544.950']] | ['Chemicals and Drugs [D]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
An investigation of the association of genetic susceptibility risk with somatic mutation burden in breast cancer. | BACKGROUND: Genome-wide association studies have reported nearly 100 common germline susceptibility loci associated with the risk for breast cancer. Tumour sequencing studies have characterised somatic mutation profiles in breast cancer patients. The relationship between breast cancer susceptibility loci and somatic mu... | ['Adult', 'Aged', 'Aged, 80 and over', 'Breast Neoplasms', 'Estrogens', 'European Continental Ancestry Group', 'Exome', 'Female', 'Genetic Predisposition to Disease', 'Genotype', 'Germ-Line Mutation', 'Humans', 'Middle Aged', 'Mutation', 'Neoplasm Proteins', 'Neoplasms, Hormone-Dependent', 'Polymorphism, Single Nucleot... | 27,467,053 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C04.588.180', 'C17.800.090.500'], ['D27.505.696.399.472.277'], ['M01.686.508.400'], ['G05.360.340.011'], ['C23.550.291.687.500', 'G05.380.355'], ['G05.380'], ['G05.365.590.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['G05... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The effects of halothane pretreatment on manganese influx induced by muscarinic stimulation of airway smooth muscle. | We hypothesized that halothane inhibits contraction of canine airway smooth muscle in part by depleting sarcoplasmic reticulum (SR) calcium stores, which affects subsequent force and calcium influx. This hypothesis was tested by using the rate of quenching of fura-2 fluorescence by manganese (Mn2+) as an index of calci... | ['Acetylcholine', 'Anesthetics, Inhalation', 'Animals', 'Calcium', 'Cholinergic Agents', 'Dogs', 'Female', 'Fura-2', 'Halothane', 'In Vitro Techniques', 'Male', 'Manganese', 'Muscle Contraction', 'Muscle, Smooth', 'Sarcoplasmic Reticulum', 'Spectrometry, Fluorescence', 'Stimulation, Chemical', 'Trachea'] | 9,174,322 | [['D02.092.211.111'], ['D27.505.696.277.100.035.060', 'D27.505.954.427.210.100.035.060'], ['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D27.505.519.625.120', 'D27.505.696.577.120'], ['B01.050.150.900.649.313.750.250.216.200'], ['D03.383.129.462.285', 'D03.633.100.127.250'], ['D02.455.526.340'], ... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Genetic dimorphism in influenza viruses: characterization of stably associated hemagglutinin mutants differing in antigenicity and biological properties. | Influenza virus recombinant X-53 produced for use in the 1976 National Immunization Program for swine influenza was found to comprise two types of virions differing in their antigenic, replicative, and plaque-forming characteristics. One type, characteristic of X-53 and designated "L," was relatively low-yielding in ch... | ['Hemagglutinins, Viral', 'Influenza A virus', 'Mutation', 'Recombination, Genetic'] | 282,644 | [['D12.776.964.970.880.345', 'D23.050.327.461'], ['B04.820.480.968.405.400'], ['G05.365.590'], ['G05.728']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Influence of pituitary hormones (hCG, TSH, Pr, GH) on testosterone level and on the functional activity of the Leydig cell in rat fetuses. | One day after the cessation of treatment the Leydig cells of the fetuses of pregnant rats, treated between the 11th and 15th or the 16th and 20th days of gestation, reacted to pituitary hormones. This finding indicates that both the receptors and the postreceptor mechanisms were in operative state. The effect of the th... | ['Animals', 'Chorionic Gonadotropin', 'Fetal Blood', 'Fetus', 'Gestational Age', 'Growth Hormone', 'Leydig Cells', 'Male', 'Prolactin', 'Rats', 'Rats, Inbred Strains', 'Reference Values', 'Testis', 'Testosterone', 'Thyrotropin'] | 3,227,855 | [['B01.050'], ['D06.472.699.322.326', 'D06.472.699.649.367', 'D12.644.548.726.367', 'D12.776.780.400'], ['A12.207.152.200', 'A15.145.300', 'A16.378.200'], ['A16.378'], ['G07.345.500.325.235.968', 'G08.686.320'], ['D06.472.699.631.525.425', 'D12.644.548.691.525.425'], ['A05.360.444.849.513', 'A06.300.312.782.513', 'A11.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
In vitro HIV infection impairs the capacity of myeloid dendritic cells to induce regulatory T cells. | Myeloid dendritic cells (mDCs) are the antigen-presenting cells best capable of promoting peripheral induction of regulatory T cells (Tregs), and are among the first targets of HIV. It is thus important to understand whether HIV alters their capacity to promote Treg conversion. Monocyte-derived DCs (moDCs) from uninfec... | ['Cell Death', 'Cell Proliferation', 'Dendritic Cells', 'Forkhead Transcription Factors', 'HIV-1', 'Humans', 'Monocytes', 'Myeloid Cells', 'T-Lymphocytes, Regulatory'] | 22,912,740 | [['G04.146'], ['G04.161.750', 'G07.345.249.410.750'], ['A11.066.270', 'A11.436.270', 'A15.382.066.270', 'A15.382.670.260'], ['D12.776.260.950.249', 'D12.776.930.977.249'], ['B04.820.650.589.650.350.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.118.637.555.652', 'A11.148.580', 'A11.627.624', 'A11.733.547... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The nurse's role in end-of-life decision-making for patients and families. | This article discusses some of the cultural changes required for organizations to build systems that move beyond mere completion of the advance directive to advance care planning that affects end-of-life decision-making. It specifically describes one organization's educational approach to clarifying the role of the nur... | ['Advance Directives', 'Decision Making', 'Humans', "Nurse's Role", 'Nurse-Patient Relations', 'Organizational Culture', 'Patient Advocacy', 'Patient Care Planning', 'Professional-Family Relations', 'Terminal Care'] | 12,494,001 | [['I01.880.604.583.020', 'N03.706.535.020', 'N04.590.233.624.124.050'], ['F02.463.785.373'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.316.616.625.450', 'N05.300.100.337'], ['F01.829.401.650.600', 'N05.300.660.560'], ['N04.452.606'], ['I01.880.604.631', 'N03.706.678'], ['N04.590.233.624'], ['F01.829.40... | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Non-CpG methylation of the PGC-1alpha promoter through DNMT3B controls mitochondrial density. | Epigenetic modification through DNA methylation is implicated in metabolic disease. Using whole-genome promoter methylation analysis of skeletal muscle from normal glucose-tolerant and type 2 diabetic subjects, we identified cytosine hypermethylation of peroxisome proliferator-activated receptor gamma (PPARgamma) coact... | ['Base Sequence', 'CpG Islands', 'DNA (Cytosine-5-)-Methyltransferases', 'DNA Methylation', 'DNA, Mitochondrial', 'Diabetes Mellitus, Type 2', 'Fatty Acids', 'Heat-Shock Proteins', 'Humans', 'Mitochondria', 'Muscle Cells', 'Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha', 'Promoter Regions, Geneti... | 19,723,495 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G02.111.570.080.380.160', 'G05.360.080.380.160', 'G05.360.340.024.159'], ['D08.811.913.555.500.350.100.500'], ['G02.111.035.538.161', 'G02.111.218', 'G03.059.538.161', 'G05.206'], ['D13.444.308.283.225'], ['C18.452.394.750.149', 'C19.246.300'], ['D10.251'], ... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Prostate tumor specific peptide-peptoid hybrid prodrugs. | Inspired by naturally occurring host defense peptides, cationic amphipathic peptoids provide a promising scaffold for anti-cancer therapeutics. Herein, we report a library of peptide-peptoid hybrid prodrugs that can be selectively activated by prostate cancer cells. We have identified several compounds demonstrating po... | ['Amino Acid Sequence', 'Antineoplastic Agents', 'Cell Line, Tumor', 'Cell Survival', 'Humans', 'Male', 'Peptides', 'Peptidomimetics', 'Peptoids', 'Prodrugs', 'Prostatic Neoplasms', 'Structure-Activity Relationship'] | 26,022,845 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D27.505.954.248'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.346'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644'], ['D27.505.519.828'], ['D12.644.679'], ['D26.675'], ['C04.588.945.440.770', 'C12.294.260.750', 'C12.294.565.625', 'C12.758.409.750'], ['G02.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Control of Lineage-Specific Gene Expression by Functionalized gRNA Barcodes. | Lineage tracking delivers essential quantitative insight into dynamic, probabilistic cellular processes, such as somatic tumor evolution and differentiation. Methods for high diversity lineage quantitation rely on sequencing a population of DNA barcodes. However, manipulation of specific individual lineages is not poss... | ['Base Sequence', 'CRISPR-Associated Protein 9', 'Cell Line, Tumor', 'Cell Lineage', 'Gene Expression', 'HEK293 Cells', 'Humans', 'Lentivirus', 'RNA, Guide'] | 30,169,961 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D08.811.277.352.355.325.150', 'D12.776.097.219', 'D12.776.212.500'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.172', 'G07.345.500.325.180.500', 'G08.686.155', 'G08.686.784.170.104.249'], ['G05.297'], ['A11.251.210.172.750', 'A11.436.334'], ['B01.050.150.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Isolated necrotizing granulomatous vasculitis of the epididymis and spermatic cords. | A 71-year-old man with a painful scrotal swelling was found to have necrotizing granulomatous vasculitis of the epididymis and spermatic cords. No systemic symptom was present, nor was there serological or haematological evidence of systemic vasculitis. | ['Aged', 'Antibodies, Antineutrophil Cytoplasmic', 'Arteries', 'Autoantibodies', 'Biomarkers', 'Epididymis', 'Humans', 'Male', 'Polyarteritis Nodosa', 'Spermatic Cord'] | 7,881,475 | [['M01.060.116.100'], ['D12.776.124.486.485.114.323.190', 'D12.776.124.790.651.114.323.190', 'D12.776.377.715.548.114.323.190', 'D23.101.050'], ['A07.015.114'], ['D12.776.124.486.485.114.323', 'D12.776.124.790.651.114.323', 'D12.776.377.715.548.114.323'], ['D23.101'], ['A05.360.444.371'], ['B01.050.150.900.649.313.988.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Phosphorylation of lysosomal hydrolases in human cancer and its significance]. | Many lysosomal hydrolases in cases of human cancer were found to be accompanied by acidic variant forms together with the major hydrolase components. Such variants were found to be phosphorylated not only at their carbohydrate moiety which contributes largely to their acidic property, but also at the protein moiety. We... | ['Adenocarcinoma', 'Animals', 'Chondro-4-Sulfatase', 'Glucuronidase', 'Humans', 'Hydrolases', 'Lung Neoplasms', 'Lysosomes', 'Mice', 'Mice, Nude', 'Neoplasm Transplantation', 'Phosphorylation', 'Protein Kinases', 'Sulfatases'] | 3,606,135 | [['C04.557.470.200.025'], ['B01.050'], ['D08.811.277.352.827.180.175.275'], ['D08.811.277.450.426'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.277'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['A11.284.430.214.190.875.190.550'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.150.90... | ['Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Shell thickness-dependent Raman enhancement for rapid identification and detection of pesticide residues at fruit peels. | Here, we report the shell thickness-dependent Raman enhancement of silver-coated gold nanoparticles (Au@Ag NPs) for the identification and detection of pesticide residues at various fruit peels. The Raman enhancement of Au@Ag NPs to a large family of sulfur-containing pesticides is ~2 orders of magnitude stronger than ... | ['Fruit', 'Gold', 'Metal Nanoparticles', 'Microscopy, Electron, Scanning', 'Pesticide Residues', 'Silver', 'Spectrum Analysis, Raman'] | 22,122,589 | [['A18.024.500', 'G07.203.300.562', 'J02.500.562'], ['D01.268.556.322', 'D01.268.956.186', 'D01.552.544.322'], ['J01.637.512.600.500'], ['E01.370.350.515.402.541', 'E05.595.402.541'], ['D27.720.031.700.672', 'D27.888.723.697', 'N06.850.460.200.700'], ['D01.268.556.812', 'D01.268.956.843', 'D01.552.544.812'], ['E05.196.... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Factors associated with functional balance and mobility among elderly diabetic outpatients. | OBJECTIVES: To characterize balance and mobility among diabetic elderly outpatients and to estimate the extent to which functional balance and mobility abnormalities can be influenced by sociodemographic, clinical and other functional factors in a cross-sectional study.METHODS: Ninety-one elderly (65+ years) outpatient... | ['Activities of Daily Living', 'Aged', 'Diabetes Mellitus', 'Epidemiologic Methods', 'Female', 'Humans', 'Hypotension, Orthostatic', 'Male', 'Mobility Limitation', 'Outpatients', 'Postural Balance', 'Proprioception', 'Socioeconomic Factors'] | 19,942,985 | [['E02.760.169.063.500.067', 'E02.831.067', 'I03.050', 'N02.421.784.110'], ['M01.060.116.100'], ['C18.452.394.750', 'C19.246'], ['E05.318', 'N06.850.520'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.177.575.600.450', 'C14.907.514.482'], ['C23.888.550'], ['M01.643.630'], ['F02.830.816.541.752', 'G07.888.750.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Mechanisms of major biliary injury during laparoscopic cholecystectomy. | Laparoscopic cholecystectomy has become the procedure of choice for surgical removal of the gallbladder. The most significant complication of this new technique is injury to the bile duct. Twelve cases of bile duct injury during laparoscopic cholecystectomy were reviewed. Eight injuries were of a classic type: misident... | ['Adult', 'Aged', 'Bile Ducts', 'Cholangiography', 'Cholecystectomy', 'Female', 'Humans', 'Intraoperative Complications', 'Laparoscopy', 'Male', 'Middle Aged', 'Wounds and Injuries'] | 1,531,913 | [['M01.060.116'], ['M01.060.116.100'], ['A03.159.183'], ['E01.370.350.700.715.200', 'E01.370.372.200'], ['E04.210.120.172'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.505'], ['E01.370.388.250.520', 'E04.502.250.520'], ['M01.060.116.630'], ['C26']] | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Microplate-based screening for small molecule inhibitors of neuropilin-2/vascular endothelial growth factor-C interactions. | Vascular endothelial growth factor-C (VEGF-C) is a secreted growth factor essential for lymphangiogenesis. VEGF-C functions in both physiological and pathological lymphangiogenesis, particularly in tumor metastasis, making it an attractive therapeutic target. Members of two families of cell surface receptors transduce ... | ['Dactinomycin', 'Dose-Response Relationship, Drug', 'Drug Discovery', 'High-Throughput Screening Assays', 'Humans', 'National Institutes of Health (U.S.)', 'Neuropilin-2', 'Phenanthridines', 'Protein Binding', 'Small Molecule Libraries', 'Structure-Activity Relationship', 'Tosyl Compounds', 'United States', 'Vascular ... | 24,583,243 | [['D03.633.300.200', 'D04.345.566.252', 'D12.644.641.252'], ['G07.690.773.875', 'G07.690.936.500'], ['E05.295', 'H01.158.703.007.675', 'H01.181.466.675'], ['E05.916.680'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I01.409.418.750.600.650.496', 'N03.540.052.750', 'N03.540.348.500.500.600.650.496'], ['D12.776.54... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 |
Mechanism of action of streptogramins and macrolides. | Protein synthesis is catalysed by ribosomes and cytoplasmic factors. Bacterial ribosomes (70S) are made up of 2 subunits (50S and 30S) containing ribosomal RNA (rRNA) and ribosomal proteins: the 30S binds messenger RNA and begins the ribosomal cycle (initiation), whereas 50S binds transfer RNA (tRNA) derivatives and co... | ['Anti-Bacterial Agents', 'Base Sequence', 'Drug Resistance, Microbial', 'Drug Synergism', 'Lincosamides', 'Macrolides', 'Molecular Sequence Data', 'Nucleic Acid Conformation', 'Virginiamycin'] | 8,724,813 | [['D27.505.954.122.085'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G06.225', 'G07.690.773.984.269'], ['G07.690.773.968.477'], ['D03.383.773.532', 'D09.408.471'], ['D02.540.505', 'D02.540.576.500', 'D04.345.674.500'], ['L01.453.245.667'], ['G02.111.570.820.486', 'G05.360.580'], ['D04.345.566.802.875'... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
tlpA gene expression is required for arginine and bicarbonate chemotaxis in Helicobacter pylori. | About half of the human population is infected with Helicobacter pylori, a bacterium causing gastritis, peptic ulcer and progression to gastric cancer. Chemotaxis and flagellar motility are required for colonization and persistence of H. pylori in the gastric mucus layer. It is not completely clear which chemical gradi... | ['Arginine', 'Bacterial Proteins', 'Bicarbonates', 'Chemotaxis', 'Gene Expression', 'Helicobacter pylori', 'Membrane Proteins', 'Methyl-Accepting Chemotaxis Proteins', 'Reverse Transcriptase Polymerase Chain Reaction', 'Signal Transduction', 'Urea'] | 22,688,915 | [['D12.125.068.050', 'D12.125.095.104', 'D12.125.142.087'], ['D12.776.097'], ['D01.200.275.150.100', 'D01.248.497.158.165.100'], ['F01.145.113.780.500', 'F01.145.875.439.500.500', 'G04.198.424', 'G07.568.500.590.500', 'G11.427.410.568.850.500'], ['G05.297'], ['B03.440.500.550', 'B03.660.150.235.500.250.550'], ['D12.776... | ['Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Lengthening of the lower limbs and correction of lumbar hyperlordosis in achondroplasia. | The analysis of more than 500 elongations carried out over a period of 15 years has led to the development of a technique of elongation of limbs in which surgical trauma and operative risk have been reduced to a minimum since all of the surgical stages are performed percutaneously. This technique results in overall elo... | ['Achondroplasia', 'Adolescent', 'Adult', 'Bone Lengthening', 'Child', 'Child, Preschool', 'Femur', 'Follow-Up Studies', 'Humans', 'Lordosis', 'Tibia'] | 2,293,921 | [['C05.116.099.343.110', 'C05.116.099.708.017', 'C16.320.240.500'], ['M01.060.057'], ['M01.060.116'], ['E04.555.120'], ['M01.060.406'], ['M01.060.406.448'], ['A02.835.232.043.150'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400']... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Evolution of immunoglobulin A nephropathy into Henoch-Sch?nlein purpura in an adult patient. | We report the first case of the evolution of immunoglobulin A (IgA) nephropathy into Henoch-Sch?nlein purpura in an adult patient. A 28-year-old man presented with an episode of gross hematuria and acute renal failure. The serum IgA level was increased and renal biopsy findings were diagnostic of IgA nephropathy. In ad... | ['Acute Kidney Injury', 'Adult', 'Glomerulonephritis, IGA', 'Hematuria', 'Humans', 'Kidney Tubular Necrosis, Acute', 'Male', 'Purpura, Schoenlein-Henoch'] | 7,847,363 | [['C12.777.419.780.050', 'C13.351.968.419.780.050'], ['M01.060.116'], ['C12.777.419.570.363.608', 'C13.351.968.419.570.363.608', 'C20.111.525'], ['C12.777.934.442', 'C13.351.968.934.442', 'C23.550.414.849'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.777.419.780.050.500', 'C13.351.968.419.780.050.500'], ['C... | ['Diseases [C]', 'Named Groups [M]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The paradoxical effects of splenectomy on tumor growth. | BACKGROUND: There is a vast and contradictory literature concerning the effect of the spleen and particularly of splenectomy on tumor growth. Sometimes splenectomy seems to inhibit tumor growth, but in other cases it seems, paradoxically, to facilitate both oncogenesis and the growth of established tumors.APPROACH: In ... | ['Animals', 'Cell Division', 'Disease Models, Animal', 'Humans', 'Mice', 'Mice, Inbred C57BL', 'Neoplasm Transplantation', 'Neoplasms', 'Splenectomy', 'Thymectomy'] | 16,800,890 | [['B01.050'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420'], ['E05.6... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Comparative transcript expression analysis of miltefosine-sensitive and miltefosine-resistant Leishmania donovani. | Leishmania donovani is the causative agent of anthroponotic visceral leishmaniasis in the Indian subcontinent. Oral miltefosine therapy has recently replaced antimonials in endemic areas. However, the drug is at risk of emergence of resistance due to unrestricted use, and, already, there are indications towards decline... | ['Antiprotozoal Agents', 'Drug Resistance', 'Gene Expression Profiling', 'Leishmania donovani', 'Oligonucleotide Array Sequence Analysis', 'Phosphorylcholine', 'RNA, Protozoan'] | 24,449,447 | [['D27.505.954.122.250.100'], ['G07.690.773.984'], ['E05.393.332'], ['B01.268.475.868.488.230'], ['E05.393.661.640', 'E05.393.760.640', 'E05.588.570.660', 'E05.601.640'], ['D02.092.877.883.333.700', 'D02.675.276.232.700'], ['D13.444.735.650']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Anorectal function after long-term transanal colonic irrigation. | AIM: The increased use of transanal colonic irrigation (TAI) warrants study of its effects on anorectal function after long term use.METHOD: Anorectal physiology tests were performed in 12 patients with chronic idiopathic constipation (CC) and 10 with idiopathic faecal incontinence (FI) [median 55 years (range 21-70)] ... | ['Adaptation, Physiological', 'Adult', 'Aged', 'Anal Canal', 'Chronic Disease', 'Constipation', 'Defecation', 'Enema', 'Fecal Incontinence', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Manometry', 'Middle Aged', 'Pressure', 'Prospective Studies', 'Rectum', 'Sensory Thresholds', 'Therapeutic Irrigation', 'Young Ad... | 20,070,334 | [['G07.025', 'G16.012.500'], ['M01.060.116'], ['M01.060.116.100'], ['A03.556.124.526.070', 'A03.556.249.249.070'], ['C23.550.291.500'], ['C23.888.821.150'], ['G10.261.165'], ['E02.319.347'], ['C06.405.469.860.300'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150... | ['Phenomena and Processes [G]', 'Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Redo Aortic and Mitral Valve Replacement by Manouguian's Procedure for Active Prosthetic Valve Infection]. | The damage to the intervalvular fibrous trigone (IVFT) by infective endocarditis makes combined aortic and mitral valve replacement difficult. We performed Manouguian's double valve replacement for such a case and obtained a good result. A 81-year-old male underwent emergency operation due to active prosthetic valve en... | ['Aged, 80 and over', 'Aortic Valve', 'Heart Valve Prosthesis', 'Heart Valve Prosthesis Implantation', 'Humans', 'Male', 'Mitral Valve', 'Prosthesis-Related Infections', 'Reoperation'] | 27,075,284 | [['M01.060.116.100.080'], ['A07.541.510.110'], ['E07.695.310'], ['E04.100.376.485', 'E04.650.410', 'E04.928.220.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A07.541.510.507'], ['C01.685', 'C23.550.767.868'], ['E04.690']] | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Flagellar filament structure and cell motility of Salmonella typhimurium mutants lacking part of the outer domain of flagellin. | We have isolated spontaneous mutants of Salmonella typhimurium which can swim in the presence of antifilament antibodies. The molecular masses of flagellins isolated from these mutants were smaller than that (52 kDa) of wild-type flagellin. Two mutants which produced the smallest flagellins (42 and 41 kDa) were selecte... | ['Amino Acid Sequence', 'Cell Movement', 'Flagella', 'Flagellin', 'Lysine', 'Molecular Sequence Data', 'Mutation', 'Polymorphism, Genetic', 'Salmonella typhimurium', 'Sequence Analysis', 'Sequence Deletion'] | 7,860,589 | [['G02.111.570.060', 'L01.453.245.667.060'], ['G04.198', 'G07.568.500.180'], ['A11.284.180.290'], ['D12.776.097.380'], ['D12.125.068.555', 'D12.125.095.647', 'D12.125.142.497'], ['L01.453.245.667'], ['G05.365.590'], ['G05.365.795'], ['B03.440.450.425.800.200.825', 'B03.660.250.150.710.160.760'], ['E05.393.760'], ['G05.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Perceived Quality of Work Life and Risk for Compassion Fatigue Among Oncology Nurses: A Mixed-Methods Study. | PURPOSE/OBJECTIVES: To examine factors that influenced the nurse's perceived quality of work life and risk for compassion fatigue (CF). The specific aims of the study were to describe the (a) relationship among nurse characteristics and perceived quality of work life, (b) relationship between personal life stress and p... | ['Adaptation, Psychological', 'Adult', 'Burnout, Professional', 'Compassion Fatigue', 'Female', 'Hospitals, Teaching', 'Hospitals, Urban', 'Humans', 'Male', 'Middle Aged', 'Nursing Staff, Hospital', 'Occupational Diseases', 'Oncology Nursing', 'Pennsylvania', 'Surveys and Questionnaires'] | 27,105,203 | [['F01.058'], ['M01.060.116'], ['C24.580.500', 'F01.145.126.990.367.500', 'F02.830.900.333.500'], ['C23.888.369.500.500', 'F01.145.126.937.500', 'F01.145.126.990.734.500', 'F02.830.900.666.750'], ['N02.278.020.300', 'N02.278.421.639'], ['N02.278.421.660'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.... | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
Plasma metabolomic profiles of breast cancer patients after short-term limonene intervention. | Limonene is a lipophilic monoterpene found in high levels in citrus peel. Limonene demonstrates anticancer properties in preclinical models with effects on multiple cellular targets at varying potency. While of interest as a cancer chemopreventive, the biologic activity of limonene in humans is poorly understood. We co... | ['Amino Acids', 'Anticarcinogenic Agents', 'Antineoplastic Agents', 'Bile Acids and Salts', 'Breast Neoplasms', 'Carnitine', 'Cell Cycle', 'Collagen', 'Cyclin D1', 'Cyclohexenes', 'Female', 'Gas Chromatography-Mass Spectrometry', 'Glucose', 'Humans', 'Limonene', 'Metabolome', 'Metabolomics', 'Plasma', 'Terpenes'] | 25,388,013 | [['D12.125'], ['D27.505.696.706.018', 'D27.505.954.248.125', 'D27.720.799.018'], ['D27.505.954.248'], ['D04.210.500.105'], ['C04.588.180', 'C17.800.090.500'], ['D02.092.877.883.099'], ['G04.144'], ['D05.750.078.280', 'D12.776.860.300.250'], ['D12.644.360.262.150.100', 'D12.776.167.218.150.100', 'D12.776.476.262.150.100... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Voltage-sensitive fluorescence of amphiphilic hemicyanine dyes in neuron membrane. | Fluorescent amphiphilic hemicyanine dyes were adsorbed to the plasma membrane of isolated Retzius neurons of the leech. Voltage steps were applied to the neuron by the patch-clamp technique in whole-cell configuration. The change of fluorescence was observed as induced by the voltage jump. The relative changes of the e... | ['Animals', 'Cell Membrane', 'Evaluation Studies as Topic', 'Fluorescent Dyes', 'Leeches', 'Membrane Potentials', 'Neurons'] | 8,347,665 | [['B01.050'], ['A11.284.149'], ['E05.337', 'N05.715.360.335'], ['D27.720.233.348', 'D27.720.470.410.505.500'], ['B01.050.500.091.426'], ['G01.154.535', 'G04.580', 'G07.265.675', 'G11.561.570'], ['A08.675', 'A11.671']] | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Morphological evidence of muscular connections between contiguous pulmonary venous orifices: relevance of the interpulmonary isthmus for catheter ablation in atrial fibrillation. | BACKGROUND: Electrophysiological studies in patients with atrial fibrillation demonstrated the presence of electrical conduction between superior and inferior left pulmonary veins (PVs) that makes electrical disconnection of individual PVs difficult. Anatomically, the prevalence, sizes, and locations of the interpulmon... | ['Adult', 'Atrial Fibrillation', 'Cadaver', 'Catheter Ablation', 'Electrophysiology', 'Endocardium', 'Female', 'Heart Atria', 'Humans', 'Male', 'Pericardium', 'Pulmonary Veins'] | 19,632,632 | [['M01.060.116'], ['C14.280.067.198', 'C23.550.073.198'], ['C23.550.260.224'], ['E02.808.750.500', 'E04.014.760.500'], ['H01.158.344.528', 'H01.158.782.236'], ['A07.541.207'], ['A07.541.358'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A07.541.795', 'A10.615.789.470'], ['A07.015.908.713']] | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Toxic variability and radiation sensitization by Pt(II) analogs in Salmonella typhimurium cells. | A rationale is presented for the development of toxic, i.e., cytocidal, antitumor drugs as clinical hypoxic cell radiation sensitizers. Pt(II) complex-induced hypoxic cell radiation sensitization may occur from Pt(II) complex in free solution and Pt(II) bound to DNA. Although both the free solution and the bound compar... | ['Carboplatin', 'Dose-Response Relationship, Radiation', 'Organoplatinum Compounds', 'Radiation-Sensitizing Agents', 'Salmonella typhimurium', 'Time Factors'] | 6,382,409 | [['D02.257.125'], ['E05.799.513.500', 'G01.750.740.500', 'G04.712.500', 'G07.225', 'G07.738.500', 'N06.850.810.250.180'], ['D02.691.788'], ['D27.505.954.600'], ['B03.440.450.425.800.200.825', 'B03.660.250.150.710.160.760'], ['G01.910.857']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Imaging of conditional gene silencing in vivo using a bioluminescence-based method with thermo-inducible microRNAs. | RNA interference (RNAi)-based gene therapy has great potential in cancer and infectious disease treatment to correct abnormal up-regulation of gene expression. We show a new original method uses synthetic microRNAs combined with a thermo-inducible promoter to reduce specific gene expression. The targeted gene is the lu... | ['Animals', 'Female', 'Fever', 'Gene Silencing', 'Glioblastoma', 'HSP70 Heat-Shock Proteins', 'Humans', 'Luciferases, Firefly', 'Luminescent Measurements', 'Mice', 'Mice, Inbred NOD', 'Mice, SCID', 'MicroRNAs', 'Optical Imaging', 'Promoter Regions, Genetic', 'RNA, Small Interfering', 'Tumor Cells, Cultured', 'Xenograft... | 29,549,271 | [['B01.050'], ['C23.888.119.344'], ['G05.308.203.374'], ['C04.557.465.625.600.380.080.335', 'C04.557.470.670.380.080.335', 'C04.557.580.625.600.380.080.335'], ['D12.776.580.216.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.682.517.750', 'D12.776.093.500.577', 'D12.776.532.510.500'], ['E05.196.712.51... | ['Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Fine needle aspiration (FNA) appearances of malignant myoepithelioma of the parotid gland. | We describe the FNA features of five cases of malignant parotid myoepithelioma, the majority of which were thought clinically to be recurrent pleomorphic adenomas. A major finding was cell shape variation: round-oval, polygonal or spindle-shaped, with basophilic cytoplasm. Many were epithelial and plasmacytoid-like and... | ['Biopsy, Needle', 'Humans', 'Male', 'Myoepithelioma', 'Parotid Neoplasms'] | 8,911,760 | [['E01.370.225.500.384.100.119', 'E01.370.225.998.054.119', 'E01.370.388.100.100', 'E04.074.119', 'E04.665.100', 'E05.200.500.384.100.119', 'E05.200.998.054.119', 'E05.242.384.100.119'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.435.585'], ['C04.588.443.591.824.695', 'C07.465.530.824.695', 'C07.465.815... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The atypical chemokine receptor CCX-CKR regulates metastasis of mammary carcinoma via an effect on EMT. | Over the last decade, the significance of the homeostatic CC chemokine receptor-7 and its ligands CC chemokine ligand-19 (CCL19) and CCL21, in various types of cancer, particularly mammary carcinoma, has been highlighted. The chemokine receptor CCX-CKR is a high-affinity receptor for these chemokine ligands but rather ... | ['Adaptive Immunity', 'Animals', 'Carcinoma', 'Chemokines', 'Epithelial-Mesenchymal Transition', 'Female', 'Homeostasis', 'Mammary Neoplasms, Experimental', 'Mice', 'Neoplasm Metastasis', 'Receptors, CCR', 'Transforming Growth Factor beta1'] | 25,027,038 | [['G12.450.050'], ['B01.050'], ['C04.557.470.200'], ['D12.644.276.374.200', 'D12.776.467.374.200', 'D23.125.300', 'D23.469.200', 'D23.529.374.200'], ['G04.356.500'], ['G07.410'], ['C04.588.531.500', 'C04.619.590', 'E05.598.500.496.843'], ['B01.050.150.900.649.313.992.635.505.500'], ['C04.697.650', 'C23.550.727.650'], [... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Disgust and the development of posttraumatic stress among soldiers deployed to Afghanistan. | Although the DSM-IV recognizes that events can traumatize by evoking horror, not just fear, the role of disgust in the development of posttraumatic stress disorder (PTSD) has received little research attention. In a study of soldiers deployed to Afghanistan, we examined whether reports of peritraumatic disgust and trai... | ['Adult', 'Afghan Campaign 2001-', 'Anxiety', 'Emotions', 'Female', 'Humans', 'Male', 'Military Personnel', 'Personality', 'Psychiatric Status Rating Scales', 'Severity of Illness Index', 'Stress Disorders, Post-Traumatic', 'Surveys and Questionnaires'] | 20,800,428 | [['M01.060.116'], ['I01.880.735.950.250.094', 'K01.400.504.984.124'], ['F01.470.132'], ['F01.470'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.526.625'], ['F01.752'], ['F04.711.513.653'], ['E05.318.308.980.438.475.456.500', 'N05.715.360.300.800.438.375.364.500', 'N06.850.520.308.980.438.475.364.500'], ['F03... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
The red cell membrane contains three different adenosine triphophatases. | Phosphorylated intermediates in the hydrolysis of ATP by human red cell membrane adenosine triphosphatases have been detected using [gamma-32-P]ATP. Intermediates formed in the presence of Mg2+ alone (MG-2+-ATPase), Mg-2+ and Na+ ((Na+,K+)-ATPase), and Mg-2+ and Ca-2+ (Ca-2+-ATPase) were separated by polyacrylamide gel... | ['Adenosine Triphosphatases', 'Calcium', 'Cell Membrane', 'Electrophoresis, Polyacrylamide Gel', 'Erythrocytes', 'Humans', 'Magnesium', 'Molecular Weight', 'Sodium'] | 122,979 | [['D08.811.277.040.025'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['A11.284.149'], ['E05.196.401.402', 'E05.301.300.319'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.268.552.437', 'D01.268.557.500', 'D01.552.547.500'], ['G02.494'], ['D01.268.... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Osteocartilaginous exostoses (osteochondromas)]. | Osteochondroma is the most common true bone neoplasm formed by a cartilage capped bony projection arising on the external surface of a bone containing a marrow cavity that is continuous with that of the underlying bone. Osteochondromas generally arise in the bones preformed by cartilage. Osteochondromas may be solitary... | ['Bone Neoplasms', 'Cartilage', 'Exostoses, Multiple Hereditary', 'Female', 'Humans', 'Male', 'Osteochondroma', 'Radiography'] | 18,368,814 | [['C04.588.149', 'C05.116.231'], ['A02.165', 'A10.165.382'], ['C04.557.450.565.575.610.615.325', 'C04.700.330', 'C05.116.099.708.670.615.325', 'C05.116.540.310.500', 'C16.320.700.330'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.450.565.575.610', 'C05.116.099.708.670'], ['E01.370.350.700']] | ['Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The Lasting Influences of Early Food-Related Variety Experience: A Longitudinal Study of Vegetable Acceptance from 5 Months to 6 Years in Two Populations. | Children's vegetable consumption falls below current recommendations, highlighting the need to identify strategies that can successfully promote better acceptance of vegetables. Recently, experimental studies have reported promising interventions that increase acceptance of vegetables. The first, offering infants a hig... | ['Adolescent', 'Adult', 'Breast Feeding', 'Child', 'Child, Preschool', 'Emotions', 'Female', 'Follow-Up Studies', 'Food Preferences', 'Humans', 'Infant', 'Longitudinal Studies', 'Male', 'Vegetables', 'Weaning'] | 26,968,029 | [['M01.060.057'], ['M01.060.116'], ['F01.145.407.199', 'G07.203.650.195', 'G07.203.650.220.500.500', 'G07.203.650.353.199'], ['M01.060.406'], ['M01.060.406.448'], ['F01.470'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['F01.145.407.516', 'G07.203.650.353.516'], ['B01.050... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
cDNA excision in stable retroviral cDNA transfectants is prevented by R removal. | The present study provides evidence on the occurrence of DNA rearrangement between the redundant 5' and 3' R domains of equine infectious anemia virus (EIAV) Tat cDNA. This was correlated with a gradual loss of cDNA copy number concomitantly with a decrease in gene expression. Removal of the 5' RU5 abolished rearrangem... | ['DNA, Complementary', 'DNA, Viral', 'Gene Expression', 'Gene Expression Regulation, Viral', 'Gene Rearrangement', 'Infectious Anemia Virus, Equine', 'Transfection'] | 9,784,417 | [['D13.444.308.497.220', 'D13.444.600.223.500', 'D27.720.470.530.600.223.260'], ['D13.444.308.568'], ['G05.297'], ['G05.308.385'], ['G05.344'], ['B04.820.650.589.520.400'], ['E05.393.350.810', 'G05.728.860']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Analysis of job satisfaction of the nursing staff of a primary health care unit]. | This was a cross-sectional, observational study conducted in an outpatient specialty district health unit in the city of Ribeir?o Preto, in the southeastern Brazilian state of S?o Paulo, with the aim to analyze the job satisfaction of the nursing staff. Data were collected using the Index of Work Satisfaction (IWS), a ... | ['Adult', 'Cross-Sectional Studies', 'Female', 'Humans', 'Job Satisfaction', 'Male', 'Middle Aged', 'Nursing Staff', 'Primary Health Care'] | 25,842,776 | [['M01.060.116'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.784.692.425'], ['M01.060.116.630'], ['M01.526.485.680', 'N02.360.680'], ['N04.590.233.727']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Trans-cervical, trans-tracheal approach to proximal tracheo-oesophageal fistula: a novel technique. | Esophageal atresia and tracheo-esophageal fistula (TEF) occur in 1/2400-4500 births. Whilst the diagnosis of esophageal atresia is readily made shortly after birth, patients with an isolated H type TEF can present with varying degrees of symptomatology which can pose a diagnostic challenge. A combination of contrast es... | ['Catheterization', 'Endoscopy', 'Esophageal Atresia', 'Female', 'Humans', 'Infant, Newborn', 'Trachea', 'Tracheoesophageal Fistula'] | 25,063,506 | [['E02.148', 'E05.157'], ['E01.370.388.250', 'E04.502.250'], ['C06.198.330', 'C06.405.117.260', 'C16.131.314.330'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['A04.889'], ['C06.267.250.725', 'C06.405.117.367.725', 'C08.702.750', 'C08.907.863', 'C23.300.575.185.250.725']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
In vitro fibrillogenesis of the amyloid beta 1-42 peptide: cholesterol potentiation and aspirin inhibition. | Understanding the formation of extracellular amyloid neurofibrillar bundles/senile plaques and their role in the development of Alzheimer's disease is of considerable interest to neuroscientists and clinicians. Major components of the extracellular neurofibrillar bundles are polymerized amyloid beta (Abeta) peptides (1... | ['Alzheimer Disease', 'Amyloid beta-Peptides', 'Animals', 'Aspirin', 'Cholesterol', 'Copper', 'Dimerization', 'Humans', 'Microscopy, Electron', 'Peptides', 'Rats', 'Sphingomyelins'] | 12,475,558 | [['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['D12.644.024', 'D12.776.049.407.249.500', 'D12.776.543.039.500'], ['B01.050'], ['D02.455.426.559.389.657.410.595.176'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['D01.268.556.195', 'D01.268.956.170', 'D01.552.544.195'], [... | ['Diseases [C]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Pulmonary sequelae after electron spinal irradiation. | We measured pulmonary function in 21 patients, after craniospinal irradiation with a posterior spinal electron beam. The median age at treatment was 7.5 years. Nine patients (43%) demonstrated abnormal pulmonary function tests, five with restrictive changes, one with isolated diminished diffusion capacity, and three wi... | ['Adolescent', 'Adult', 'Central Nervous System Neoplasms', 'Child', 'Child, Preschool', 'Cranial Irradiation', 'Female', 'Humans', 'Male', 'Medulloblastoma', 'Radiation Pneumonitis', 'Radiotherapy Dosage', 'Radiotherapy, High-Energy', 'Respiratory Function Tests', 'Spine'] | 11,514,006 | [['M01.060.057'], ['M01.060.116'], ['C04.588.614.250', 'C10.551.240'], ['M01.060.406'], ['M01.060.406.448'], ['E02.815.190'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.465.625.600.380.515', 'C04.557.465.625.600.590.500', 'C04.557.470.670.380.515', 'C04.557.470.670.590.500', 'C04.557.580.625.600.380.515... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
ROMEO: a rapid rule out strategy for low risk chest pain. Does it work in a UK emergency department? | AIMS: To examine the feasibility of using the ROMEO (rule out myocardial events on "obs" ward) pathway for low risk patients with chest pain in a UK emergency department.METHODS: A prospective study was undertaken to determine outcomes for the first 100 patients entering the pathway (from May to Oct 1999). Serum tropon... | ['Adult', 'Chest Pain', 'Critical Pathways', 'Decision Making', 'Electrocardiography', 'Emergency Service, Hospital', 'Feasibility Studies', 'Hospitals, General', 'Humans', 'Risk Assessment', 'Troponin I', 'United Kingdom'] | 12,204,983 | [['M01.060.116'], ['C23.888.592.612.233'], ['N04.590.233.624.625', 'N04.590.275'], ['F02.463.785.373'], ['E01.370.370.380.240', 'E01.370.405.240'], ['N02.278.216.500.968.336', 'N02.421.297.195', 'N04.452.442.452.422.336'], ['E05.318.372.550', 'E05.337.675', 'N05.715.360.330.550', 'N06.850.520.450.550'], ['N02.278.421.3... | ['Named Groups [M]', 'Diseases [C]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
A United Kingdom coordinating committee on cancer research study of adjuvant chemotherapy for colorectal cancer: preliminary results. | Standard adjuvant chemotherapy for colorectal cancer consists of 5-fluorouracil with leucovorin or levamisole. The large, multicenter, randomized, double-blind QUASAR (Quick and Simple and Reliable) trial investigated whether treatment with a higher dose of leucovorin or the addition of levamisole to 5-fluorouracil and... | ['Adjuvants, Immunologic', 'Aged', 'Antimetabolites, Antineoplastic', 'Chemotherapy, Adjuvant', 'Colorectal Neoplasms', 'Double-Blind Method', 'Drug Administration Schedule', 'Female', 'Fluorouracil', 'Humans', 'Leucovorin', 'Levamisole', 'Male', 'Middle Aged', 'Neoplasm Recurrence, Local', 'Odds Ratio', 'Prospective S... | 11,273,587 | [['D27.505.696.477.067'], ['M01.060.116.100'], ['D27.505.519.186.144', 'D27.505.954.248.144', 'D27.888.569.042.030'], ['E02.186.170', 'E02.319.170'], ['C04.588.274.476.411.307', 'C06.301.371.411.307', 'C06.405.249.411.307', 'C06.405.469.158.356', 'C06.405.469.491.307', 'C06.405.469.860.180'], ['E05.318.370.300', 'E05.5... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Cytoprotective effect of silybin against lasalocid-induced toxicity in HepG2 cells. | Lasalocid is an ionophore coccidiostatic agent frequently used in poultry. Its extensive use causes the formation of residues in edible tissues and eggs which may pose a risk to consumers. Silybin is the main compound extracted from the herb milk thistle Silybum marianum and its hepatoprotective effect has been reporte... | ['Cell Survival', 'Cytoprotection', 'Hep G2 Cells', 'Hepatocytes', 'Humans', 'Lasalocid', 'Silybin', 'Silymarin'] | 23,971,195 | [['G04.346'], ['G07.690.773.500'], ['A11.251.860.180.432', 'A11.436.348.500'], ['A11.436.348'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.383.312.490'], ['D03.383.663.283.266.450.268.777.500', 'D03.633.100.150.266.450.268.777.500'], ['D03.383.663.283.266.450.268.777', 'D03.633.100.150.266.450.268.777']] | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Integrative content-driven concepts for bioinformatics "beyond the cell". | Bioinformatics has delivered great contributions to genome and genomics research, without which the world-wide success of this and other global ('omics') approaches would not have been possible. More recently, it has developed further towards the analysis of different kinds of networks thus laying the foundation for co... | ['Animals', 'Cell Communication', 'Cell Physiological Phenomena', 'Computational Biology', 'Databases, Genetic', 'Gene Regulatory Networks', 'Genomics', 'Hormones', 'Humans', 'Metabolic Networks and Pathways', 'Signal Transduction', 'Systems Biology'] | 17,426,389 | [['B01.050'], ['G04.085'], ['G04'], ['H01.158.273.180', 'L01.313.124'], ['L01.313.500.750.300.188.400.325', 'L01.470.750.750.325'], ['G05.360.080.689.360'], ['H01.158.273.180.350', 'H01.158.273.343.350'], ['D06.472', 'D27.505.696.399.472'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G03.493'], ['G02.111.820', '... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Information Science [L]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
[The reaction of hyperbasophilic mononucleated cells during P. falciparum malaria; its role in the immune response]. | In 34 patients with a primary attack of P. falciparum malaria, hyperbasophilic mononucleated cells (atypical lymphocytes) were found 22 times. These cells appeared around the 3rd or 4th day of fever and represented 4 to 10% of all white blood cells in 14 cases, 10 to 15% in 6 cases, and 15 to 21% in 2 cases. Their tran... | ['Cell Count', 'Humans', 'Killer Cells, Natural', 'Lymphocytes', 'Malaria', 'Plasmodium falciparum'] | 394,863 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Argyrophilic neuroendocrine carcinoma of the male breast. | A case of breast carcinoma with neuroendocrine features occurring in an elderly male patient is reported. Histologically, the tumor was characterized by solid growth with nests and ribbons of small to medium-size uniform neoplastic cells. Argyrophilia, expression of chromogranins at both protein and gene level, and the... | ['Aged', 'Aged, 80 and over', 'Breast Neoplasms', 'Carcinoid Tumor', 'Carcinoma', 'Chromogranins', 'Cytoplasmic Granules', 'Humans', 'Male', 'Microscopy, Electron', 'Phosphopyruvate Hydratase'] | 8,427,027 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['C04.588.180', 'C17.800.090.500'], ['C04.557.465.625.650.200', 'C04.557.470.200.025.200', 'C04.557.580.625.650.200'], ['C04.557.470.200'], ['D12.776.631.199', 'D12.776.811.185'], ['A11.284.430.214.190.500', 'A11.284.430.214.190.875.190.190'], ['B01.050.150.900.649.313.988... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Laparoscopic lymph node dissection around the inferior mesenteric artery for left-sided colon and rectal cancer. | Lymph node dissection is a critical part of surgery for colorectal cancer. Japanese D3 and complete mesocolic excision are two unique principles for lymph node dissection in colorectal cancer. Laparoscopic surgery magnifies the targets and provides insight about the micro-anatomy through high-quality, high-definition i... | ['Colorectal Neoplasms', 'Digestive System Surgical Procedures', 'Feasibility Studies', 'Humans', 'Laparoscopy', 'Lymph Node Excision', 'Lymph Nodes', 'Mesenteric Artery, Inferior', 'Surgery, Computer-Assisted'] | 28,993,920 | [['C04.588.274.476.411.307', 'C06.301.371.411.307', 'C06.405.249.411.307', 'C06.405.469.158.356', 'C06.405.469.491.307', 'C06.405.469.860.180'], ['E04.210'], ['E05.318.372.550', 'E05.337.675', 'N05.715.360.330.550', 'N06.850.520.450.550'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.388.250.520', 'E04.50... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Anti-neuroblastoma monoclonal antibodies which do not bind to bone marrow cells. | Three previously unreported mouse monoclonal antibodies are described. All three bind to cultured human neuroblastoma cells from six of six cell lines, but do not detectably bind to human bone marrow cells. The two IgG2a monoclonal antibodies bind to greater than 98% of the cultured cells from each cell line, bind to s... | ['Animals', 'Antibodies, Monoclonal', 'Antibody-Dependent Cell Cytotoxicity', 'Binding Sites, Antibody', 'Bone Marrow', 'Bone Marrow Cells', 'Cell Survival', 'Child', 'Child, Preschool', 'Complement System Proteins', 'Female', 'Fluorescent Antibody Technique', 'Hematopoietic Stem Cells', 'Humans', 'Immunoenzyme Techniq... | 3,887,430 | [['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['G12.287.070'], ['G02.111.570.060.425.079', 'G02.111.570.120.408', 'G12.122.232', 'G12.125'], ['A15.382.216'], ['A11.148', 'A15.378.316'], ['G04.346'], ['M01.060.406'], ['M01.060.406.448'], ['D12.776.124.486.27... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Setting a standard: the limulus amebocyte lysate assay and the assessment of microbial contamination on spacecraft surfaces. | Historically, colony-forming units as determined by plate cultures have been the standard unit for microbiological analysis of environmental samples, medical diagnostics, and products for human use. However, the time and materials required make plate cultures expensive and potentially hazardous in the closed environmen... | ['Animals', 'Bacteria', 'Colony Count, Microbial', 'Endotoxins', 'Limulus Test', 'Meat', 'Meat-Packing Industry', 'Reference Standards', 'Spacecraft', 'United States', 'United States National Aeronautics and Space Administration'] | 21,087,163 | [['B01.050'], ['B03'], ['E01.370.225.875.220', 'E05.200.875.220'], ['D23.946.123.329'], ['E01.370.225.124.470', 'E01.370.225.875.150.570', 'E05.091.570', 'E05.200.124.470', 'E05.200.875.150.570'], ['G07.203.300.600', 'J02.500.600'], ['J01.576.423.200.700'], ['E05.978.808'], ['J01.937.285.850.900'], ['Z01.107.567.875'],... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 |
[Effect of hypoxia on the viability of rat brain astrocytes in vitro]. | OBJECTIVE: To investigate the effect of hypoxia on the viability of rat brain astrocytes in vitro and determine the optimal duration of hypoxic treatment for studying the biological behavior of the in vitro cultured cells in response to hypoxia.METHODS: Rat astrocytes were cultured and identified by glial fibrillary ac... | ['Animals', 'Animals, Newborn', 'Astrocytes', 'Brain', 'Cell Hypoxia', 'Cell Survival', 'Cells, Cultured', 'Female', 'Glial Fibrillary Acidic Protein', 'L-Lactate Dehydrogenase', 'Male', 'Rats', 'Rats, Sprague-Dawley'] | 15,837,637 | [['B01.050'], ['B01.050.050.282'], ['A08.637.200', 'A11.650.200'], ['A08.186.211'], ['G03.197.300', 'G04.270.300'], ['G04.346'], ['A11.251'], ['D05.750.078.593.400', 'D12.776.220.475.400'], ['D08.811.682.047.551.400', 'D08.811.682.047.820.493'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Splenectomy in gynecologic oncology: indications, complications, and technique. | Although uncommonly performed in this setting, splenectomy is sometimes indicated in patients with gynecologic malignancies. From January 1970 through March 1989, 45 patients at The University of Texas M.D. Anderson Cancer Center underwent splenectomy during the course of gynecologic laparotomies. All procedures were p... | ['Adult', 'Aged', 'Aged, 80 and over', 'Female', 'Genitalia, Female', 'Humans', 'Iatrogenic Disease', 'Intraoperative Complications', 'Middle Aged', 'Morbidity', 'Postoperative Complications', 'Retrospective Studies', 'Spleen', 'Splenectomy'] | 1,743,552 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['A05.360.319'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.291.875'], ['C23.550.505'], ['M01.060.116.630'], ['E05.318.308.985.525', 'N01.224.935.597', 'N06.850.505.400.975.525', 'N06.850.520.308.985.525'], ['C23.550.767'], ['E05.318.372.50... | ['Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Human rabies: epidemiological and laboratory studies in 80 cases. | Epidemiological and laboratory studies were conducted on 80 clinically diagnosed human rabies cases. Incidence of rabies was more in adult males (55%) and boys (37.5%) than adult females (5%) and girls (2.5%) and more in rural areas (76.2%) than urban areas (23.8%). Dogs constituted the main vector of transmission (92.... | ['Adult', 'Child', 'Demography', 'Female', 'Humans', 'Incidence', 'India', 'Male', 'Rabies', 'Sex Factors'] | 1,401,970 | [['M01.060.116'], ['M01.060.406'], ['I01.240', 'N01.224', 'N06.850.505.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.985.525.375'], ['Z01.252.245.393'], ['C01.925.782.580.830.750'], ['N05.715.350.675', 'N06.850.... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Efficacy of different therapeutic regimens on hepatic osteodystrophy in chronic viral liver disease. | BACKGROUND AND AIMS: Metabolic bone disease is common in patients with chronic liver disease. Comparative studies on the efficacies of antiosteoporotic agents in hepatic osteodystrophy have not been conducted yet. The aim of this study was to evaluate the safety and efficacy of different therapeutic regimens on hepatic... | ['Absorptiometry, Photon', 'Adult', 'Alendronate', 'Biomarkers', 'Bone Density', 'Bone Density Conservation Agents', 'Bone Diseases, Metabolic', 'Calcitonin', 'Chronic Disease', 'Etidronic Acid', 'Female', 'Hepatitis, Viral, Human', 'Humans', 'Male', 'Middle Aged', 'Osteoporosis', 'Prospective Studies', 'Risedronic Aci... | 21,971,374 | [['E01.370.350.700.024', 'E05.196.712.224.187'], ['M01.060.116'], ['D02.705.429.500.100'], ['D23.101'], ['G11.427.100'], ['D27.505.696.242'], ['C05.116.198', 'C18.452.104'], ['D06.472.699.150', 'D06.472.931.052', 'D12.644.400.095', 'D12.644.548.150', 'D12.776.631.650.095'], ['C23.550.291.500'], ['D02.705.429.500.830'],... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Inhibition of autophagic turnover in â-cells by fatty acids and glucose leads to apoptotic cell death. | Autophagy, a cellular recycling process responsible for turnover of cytoplasmic contents, is critical for maintenance of health. Defects in this process have been linked to diabetes. Diabetes-associated glucotoxicity/lipotoxicity contribute to impaired â-cell function and have been implicated as contributing factors to... | ['Adult', 'Animals', 'Apoptosis', 'Autophagy', 'Autophagy-Related Protein 7', 'Cell Line', 'Diabetes Mellitus', 'Fatty Acids', 'Female', 'Glucose', 'Humans', 'Insulin-Secreting Cells', 'Male', 'Mechanistic Target of Rapamycin Complex 1', 'Multiprotein Complexes', 'Signal Transduction', 'TOR Serine-Threonine Kinases', '... | 25,548,282 | [['M01.060.116'], ['B01.050'], ['G04.146.954.035'], ['G04.011'], ['D12.776.094.399'], ['A11.251.210'], ['C18.452.394.750', 'C19.246'], ['D10.251'], ['D09.947.875.359.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A03.734.414.131', 'A06.300.414.087', 'A06.390.131', 'A11.382.625.092', 'A11.436.294.092'], ['D05... | ['Named Groups [M]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Hyperandrogenism and phenotypes of polycystic ovary syndrome are not associated with differences in obstetric outcomes. | OBJECTIVES: To investigate obstetric outcomes in Danish women with different phenotypes of polycystic ovary syndrome (PCOS) and isolated hyperandrogenism (HA) and describe the risk of adverse obstetric outcomes in women with PCOS and HA compared to controls.DESIGN: Cohort study.SETTING: Odense University Hospital, Denm... | ['Adult', 'Body Mass Index', 'Female', 'Humans', 'Hyperandrogenism', 'Infant, Newborn', 'Phenotype', 'Polycystic Ovary Syndrome', 'Pregnancy', 'Pregnancy Outcome', 'Sex Hormone-Binding Globulin'] | 25,417,943 | [['M01.060.116'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.706.316.064.500', 'C12.706.316.090.750', 'C13.351.875.253.064.500', 'C13.351.875.253.090.750', 'C16.131.939.316.064.500', 'C16.131.939.316.129.750', 'C19... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Integrins are not essential for entry of coxsackievirus A9 into SW480 human colon adenocarcinoma cells. | BACKGROUND: Coxsackievirus A9 (CV-A9) is a pathogenic enterovirus type within the family Picornaviridae. CV-A9 infects A549 human epithelial lung carcinoma cells by attaching to the áVâ6 integrin receptor through a highly conserved Arg-Gly-Asp (RGD) motif, which is located at the exposed carboxy-terminus of the capsid ... | ['Antigens, Neoplasm', 'Cell Line, Tumor', 'Enterovirus B, Human', 'Epithelial Cells', 'Host-Pathogen Interactions', 'Humans', 'Integrins', 'Receptors, Virus', 'Virus Internalization'] | 27,756,316 | [['D23.050.285'], ['A11.251.210.190', 'A11.251.860.180'], ['B04.820.578.750.284.182'], ['A11.436'], ['G06.462', 'G16.527.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.543.750.705.408'], ['D12.776.543.750.830'], ['G06.920.881']] | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Hospitalized elders: changes in functional and mental status. | This article describes outcomes of a new model of care for hospitalized elders and their families. Patient functional and cognitive status on admission and discharge were evaluated for changes as a result of an educational program for preparing family-centered geriatric resource nurses. Patients in the intervention gro... | ['Activities of Daily Living', 'Aged', 'Aged, 80 and over', 'Education, Nursing, Continuing', 'Family Nursing', 'Geriatric Assessment', 'Geriatric Nursing', 'Hospitalization', 'Hospitals, Voluntary', 'Humans', 'Inservice Training', 'Mental Competency', 'Mental Status Schedule', 'Models, Nursing', 'New York', 'Nurse Cli... | 14,740,585 | [['E02.760.169.063.500.067', 'E02.831.067', 'I03.050', 'N02.421.784.110'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['I02.358.212.450', 'I02.358.462.399'], ['H02.478.676.218'], ['E05.318.308.225', 'I01.240.425.350', 'N01.224.425.350', 'N05.715.360.300.360', 'N06.850.505.400.425.350', 'N06.850.520.308.225'], ['H02.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Named Groups [M]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
An estimate of the heritable fraction of childhood cancer. | We have reviewed the records of the 16,564 cases of childhood cancer diagnosed from 1971 to 1983 which were reported to the National Registry of Childhood Tumours in Great Britain for the presence of underlying genetic disease in order to estimate the proportion which results from inherited mutations. A genetic conditi... | ['Child', 'Genetic Diseases, Inborn', 'Humans', 'Immunologic Deficiency Syndromes', 'Leukemia', 'Neoplasms', 'Registries', 'United Kingdom'] | 2,069,856 | [['M01.060.406'], ['C16.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C20.673'], ['C04.557.337'], ['C04'], ['E05.318.308.970', 'N04.452.859.819', 'N05.715.360.300.715.700', 'N06.850.520.308.970'], ['Z01.542.363']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Molecular basis of cooperative DNA bending and oriented heterodimer binding in the NFAT1-Fos-Jun-ARRE2 complex. | Cooperative DNA binding by transcription factors that bind to separate recognition sites is likely to require bending of intervening sequences and the appropriate orientation of transcription factor binding. We investigated DNA bending in complexes formed by the basic region-leucine zipper domains of Fos and Jun with t... | ['Animals', 'Binding Sites', 'Crystallography, X-Ray', 'DNA', 'DNA-Binding Proteins', 'Dimerization', 'NFATC Transcription Factors', 'Nuclear Proteins', 'Protein Binding', 'Proto-Oncogene Proteins c-fos', 'Proto-Oncogene Proteins c-jun', 'Transcription Factors'] | 9,653,115 | [['B01.050'], ['G02.111.570.120'], ['E05.196.309.742.225'], ['D13.444.308'], ['D12.776.260'], ['G02.206', 'G03.230'], ['D12.776.930.608'], ['D12.776.660'], ['G02.111.679', 'G03.808'], ['D12.776.260.108.765', 'D12.776.624.664.700.179', 'D12.776.660.760', 'D12.776.930.127.765'], ['D12.776.260.108.820', 'D12.776.624.664.7... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Activated human B cells stimulate COX-2 expression in follicular dendritic cell-like cells via TNF-á. | In spite of the potential importance of cyclooxygenase (COX)-2 expression in the germinal center, its underlying cellular and molecular mechanisms are largely unknown. COX-2 is the key enzyme generating pleiotropic prostaglandins. Based on our previous findings, we hypothesized that lymphocytes would stimulate COX-2 ex... | ['B-Lymphocytes', 'Cells, Cultured', 'Cyclooxygenase 2', 'Dendritic Cells, Follicular', 'Humans', 'Lymphocyte Activation', 'Palatine Tonsil', 'Signal Transduction', 'Tumor Necrosis Factor-alpha', 'Up-Regulation'] | 29,241,029 | [['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['A11.251'], ['D08.811.600.720.750'], ['A10.549.400.500.200', 'A11.066.275', 'A15.382.066.275', 'A15.382.520.604.412.500.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.812.482... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
msaABCR operon positively regulates biofilm development by repressing proteases and autolysis in Staphylococcus aureus. | Staphylococcus aureus is an important human pathogen that causes nosocomial and community-acquired infections. One of the most important aspects of staphylococcal infections is biofilm development within the host, which renders the bacterium resistant to the host's immune response and antimicrobial agents. Biofilm deve... | ['Bacteriolysis', 'Biofilms', 'Gene Expression Regulation, Bacterial', 'Microscopy, Confocal', 'N-Acetylmuramoyl-L-alanine Amidase', 'Operon', 'Peptide Hydrolases', 'Real-Time Polymerase Chain Reaction', 'Sequence Deletion', 'Staphylococcus aureus'] | 25,724,778 | [['G06.099.115'], ['A20.593', 'G06.120'], ['G05.308.300'], ['E01.370.350.515.395', 'E05.595.395'], ['D08.811.277.087.030'], ['G05.360.340.024.686', 'G05.360.340.358.207.500'], ['D08.811.277.656'], ['E05.393.620.500.706'], ['G05.365.590.762', 'G05.558.800'], ['B03.300.390.400.800.750.100', 'B03.353.500.750.750.100', 'B0... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Isolation and characterization of a new 110 kDa human nuclear RNA-binding protein (p110nrb). | RNA-protein interactions play key roles in many fundamental cellular processes such as RNA processing, RNA transport, and RNA translation. During our attempts to isolate the human U6 small nuclear RNA capping enzyme, we identified a new 110 kDa nuclear RNA-binding protein, designated p110nrb. The full-length cDNA clone... | ['Amino Acid Sequence', 'Animals', 'Antigens, Neoplasm', 'Caenorhabditis elegans', 'Cells, Cultured', 'Humans', 'Insecta', 'Molecular Sequence Data', 'Nuclear Proteins', 'RNA, Nuclear', 'RNA-Binding Proteins', 'Recombinant Fusion Proteins', 'Sequence Alignment', 'Sequence Homology, Amino Acid'] | 9,714,707 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D23.050.285'], ['B01.050.500.500.294.400.875.660.250.250'], ['A11.251'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.500.131.617'], ['L01.453.245.667'], ['D12.776.660'], ['D13.444.735.628'], ['D12.776.157.725', 'D12.776.664.962'], ['D12.776.828.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Impedance monitoring during radiofrequency catheter ablation in humans. | Radiofrequency catheter ablation of accessory pathways and the atrioventricular junction often requires multiple applications of energy. The inability to determine the effects of any given application on the underlying tissue may contribute to this problem. In the present study, impedance was monitored in 20 patients u... | ['Adult', 'Atrioventricular Node', 'Electric Conductivity', 'Electrocardiography', 'Electrocoagulation', 'Female', 'Heart Conduction System', 'Humans', 'Male', 'Monitoring, Intraoperative', 'Radio Waves', 'Tachycardia, Supraventricular', 'Wolff-Parkinson-White Syndrome'] | 1,370,996 | [['M01.060.116'], ['A07.541.409.147'], ['G01.358.500.249.277'], ['E01.370.370.380.240', 'E01.370.405.240'], ['E02.154.402', 'E04.014.170.402'], ['A07.541.409'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.520.510', 'E04.510'], ['G01.358.500.505.810', 'G01.750.250.810', 'G01.750.770.721'], ['C14.280.067.8... | ['Named Groups [M]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Pharmacokinetics and pharmacodynamics of obidoxime in sarin-poisoned rats. | The pharmacokinetics and pharmacodynamics of the oxime obidoxime (Toxogonin, 50 mg/kg iv) were investigated in anesthetized normal rats and in sarin-poisoned (50 micrograms/kg iv) rats. The kinetics were described by a two-compartment open model. The elimination half-life ranged from 35 min in normal rats to 86 min in ... | ['Acetylcholine', 'Animals', 'Atropine', 'Blood Pressure', 'Female', 'Obidoxime Chloride', 'Rats', 'Receptors, Cholinergic', 'Receptors, Nicotinic', 'Sarin'] | 2,020,972 | [['D02.092.211.111'], ['B01.050'], ['D02.145.074.722.229.199', 'D03.132.760.180.572.199', 'D03.132.889.180.648.199', 'D03.605.084.500.722.229.199', 'D03.605.869.229.199'], ['E01.370.600.875.249', 'G09.330.380.076'], ['D02.092.570.665.500', 'D03.383.725.762.600'], ['B01.050.150.900.649.313.992.635.505.700'], ['D12.776.5... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Acute toxicity studies of Croton membranaceus root extract. | AIM OF THE STUDY: Croton membranaceus root and leaf extracts are used in the Bahamas to aromatize tobacco, in Nigeria to improve digestion, and in Ghana, for benign prostate hyperplasia. Despite claims of success there is paucity of information on its toxicity. The aim of this study was to determine if Croton membranac... | ['Animals', 'Blood Cell Count', 'Clinical Chemistry Tests', 'Croton', 'Male', 'Plant Extracts', 'Plant Roots', 'Rats', 'Rats, Sprague-Dawley'] | 21,335,084 | [['B01.050'], ['E01.370.225.500.195.107', 'E01.370.225.625.107', 'E05.200.500.195.107', 'E05.200.625.107', 'E05.242.195.107', 'G04.140.107', 'G09.188.105'], ['E01.370.225.124', 'E05.200.124'], ['B01.650.940.800.575.912.250.859.797.438.199'], ['D20.215.784.500', 'D26.667'], ['A18.400'], ['B01.050.150.900.649.313.992.635... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Hepatocellular carcinoma: Can it be considered a controversial indication for liver transplantation in centers with high rates of hepatitis C? | Hepatocellular carcinoma (HCC) is still considered a controversial indication for liver transplantation (LT), mainly because of long waiting times and underlying viral cirrhosis. The goal was to evaluate the outcome of LT in 104 patients with HCC and cirrhosis, mainly hepatitis C virus (HCV)-related, in a center with a... | ['Adult', 'Aged', 'Carcinoma, Hepatocellular', 'Female', 'Hepatitis C', 'Humans', 'Liver', 'Liver Neoplasms', 'Liver Transplantation', 'Male', 'Middle Aged', 'Neoplasm Recurrence, Local', 'Prognosis', 'Survival Analysis', 'Time Factors', 'Waiting Lists'] | 12,424,715 | [['M01.060.116'], ['M01.060.116.100'], ['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['C01.221.250.750', 'C01.925.440.440', 'C01.925.782.350.350', 'C06.552.380.705.440'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A03.620'], ['C04.588.274.623', 'C06.301.623', 'C06.552... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A functional enhanced green fluorescent protein (EGFP)-tagged angiotensin II at(1a) receptor recruits the endogenous Galphaq/11 protein to the membrane and induces its specific internalization independently of receptor-g protein coupling in HEK-293 cells. | The angiotensin II (Ang II) AT(1A) receptor was tagged at its C terminus with the enhanced green fluorescent protein (EGFP), and the corresponding chimeric cDNA was expressed in HEK-293 cells. This tagged receptor presents wild-type pharmacological and signaling properties and can be immunodetected by Western blotting ... | ['Angiotensin II', 'Cell Line', 'Cell Membrane', 'Cytoplasm', 'Dose-Response Relationship, Drug', 'Embryo, Mammalian', 'GTP-Binding Protein alpha Subunits, Gq-G11', 'GTP-Binding Proteins', 'Gene Expression', 'Green Fluorescent Proteins', 'Heterotrimeric GTP-Binding Proteins', 'Humans', 'Kidney', 'Kinetics', 'Luminescen... | 11,158,335 | [['D06.472.699.094.078', 'D12.644.400.070.078', 'D12.644.456.073.041', 'D12.644.548.058.078', 'D12.776.631.650.070.078', 'D23.469.050.050.050'], ['A11.251.210'], ['A11.284.149'], ['A11.284.430.214'], ['G07.690.773.875', 'G07.690.936.500'], ['A16.254'], ['D08.811.277.040.330.300.200.100.300', 'D12.644.360.360.100.300', ... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of continuous opioid receptor blockade on alcohol intake and up-regulation of opioid receptor subtype signalling in a genetic model of high alcohol drinking. | Effects of a continuous naloxone infusion via osmotic pumps on alcohol drinking and opioid receptor density and function in the high-drinking AA (Alko, Alcohol) rats were examined. AA rats were trained to drink 10% (v/v) ethanol in a 1-h limited access procedure and implanted with subcutaneous osmotic pumps delivering ... | ['Alcohol Drinking', 'Analgesia', 'Animals', 'Autoradiography', 'Dose-Response Relationship, Drug', 'Drinking', 'Drug Interactions', 'Eating', 'GTP-Binding Proteins', "Guanosine 5'-O-(3-Thiotriphosphate)", 'Ligands', 'Male', 'Morphine', 'Naloxone', 'Narcotic Antagonists', 'Rats', 'Receptors, Opioid', 'Time Factors', 'U... | 10,551,276 | [['F01.145.317.269'], ['E03.091'], ['B01.050'], ['E01.370.225.750.132', 'E05.200.750.132', 'E05.799.256'], ['G07.690.773.875', 'G07.690.936.500'], ['G07.203.650.283.249', 'G10.261.330.249'], ['G07.690.773.968'], ['G07.203.650.283', 'G10.261.330'], ['D08.811.277.040.330.300', 'D12.776.157.325'], ['D02.886.765.380', 'D13... | ['Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
How do dispersal costs and habitat selection influence realized population connectivity? | Despite the importance of dispersal for population connectivity, dispersal is often costly to the individual. A major impediment to understanding connectivity has been a lack of data combining the movement of individuals and their survival to reproduction in the new habitat (realized connectivity). Although mortality o... | ['Animals', 'Bryozoa', 'Demography', 'Ecosystem', 'Larva', 'Models, Biological'] | 22,834,378 | [['B01.050'], ['B01.050.500.217'], ['I01.240', 'N01.224', 'N06.850.505.400'], ['G16.500.275.157', 'N06.230.124'], ['B05.500.500', 'G07.345.500.550.500.500'], ['E05.599.395']] | ['Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
RNA in Salivary Extracellular Vesicles as a Possible Tool for Systemic Disease Diagnosis. | Saliva contains biological information as blood and is recognized as a valuable diagnostic medium for their noninvasiveness. Although "-omics" researches have tried to investigate saliva, the origin and significance of its contents are not clear, and its usage is largely confined to oral disease in the diagnostic and p... | ['Animals', 'Biomarkers', 'Blotting, Western', 'Cell Line, Tumor', 'Dextrans', 'Disease Models, Animal', 'Extracellular Vesicles', 'Humans', 'Liquid-Liquid Extraction', 'Melanoma', 'Mice', 'Mice, Inbred BALB C', 'Mice, Nude', 'Microscopy, Electron, Transmission', 'Polyethylene Glycols', 'Polymerase Chain Reaction', 'RN... | 28,410,004 | [['B01.050'], ['D23.101'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['A11.251.210.190', 'A11.251.860.180'], ['D05.750.078.562.272', 'D09.698.365.272'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['A11.284.295.588'], ['B01.050.150.900.649.313.988.400.112.40... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Micelle-mediated extraction for concentrating hydrophobic organic compounds. | An extraction method based on polymer-induced phase separation of aqueous micellar solutions of octyl-beta-D-thioglucoside (OTG) was assessed for concentrating hydrophobic analytes. Various hydrophobic compounds such as polycyclicaromatic hydrocarbons, alkylbenzenes, alkylphenols, chlorobenzenes, chlorophenols, phthali... | ['Chromatography, High Pressure Liquid', 'Micelles', 'Organic Chemicals', 'Spectrophotometry, Ultraviolet', 'Thioglucosides', 'Water'] | 10,893,028 | [['E05.196.181.400.300'], ['D05.374', 'D26.255.560'], ['D02'], ['E05.196.712.726.802', 'E05.196.867.826.802'], ['D02.886.740.703', 'D09.408.348.820', 'D09.408.903.703'], ['D01.045.250.875', 'D01.248.497.158.459.650', 'D01.650.550.925']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Oxidative metabolism of ferrocene analogues of tamoxifen: characterization and antiproliferative activities of the metabolites. | Ferrociphenols have been found to have high antiproliferative activity against estrogen-independent breast cancer cells. The rat and human liver microsome-mediated metabolism of three compounds of the ferrocifen (FC) family, 1,1-bis(4-hydroxyphenyl)-2-ferrocenyl-but-1-ene (FC1), 1-(4-hydroxyphenyl)-1-(phenyl)-2-ferroce... | ['Antineoplastic Agents, Phytogenic', 'Cell Line, Tumor', 'Cell Proliferation', 'Cyclization', 'Cytochrome P-450 Enzyme System', 'Ferrous Compounds', 'Humans', 'Metallocenes', 'Microsomes', 'Oxidation-Reduction', 'Tamoxifen'] | 25,882,581 | [['D27.505.954.248.179'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.161.750', 'G07.345.249.410.750'], ['G02.111.180', 'G02.607.133', 'G03.208'], ['D08.244.453', 'D08.811.682.690.708.170', 'D12.776.422.220.453'], ['D01.490.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.691.657'], ['A11.284.835.540'], ... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Exophiala pisciphila. A study of its development. | Exophiala pisciphila is a dematiaceous fungus that belongs to a group of fungi known as the 'black yeasts'. It was isolated from the skin lesions of a smooth dogfish, Mustelus canis Mitchill, that had been born in the shark exhibit tank of the New York Aquarium. The different stages of development of this fungus were s... | ['Animals', 'Culture Media', 'Dogfish', 'Exophiala', 'Fish Diseases', 'Fishes', 'Microscopy, Electron, Scanning', 'Mitosporic Fungi', 'Mycoses'] | 3,713,799 | [['B01.050'], ['D27.720.470.305', 'E07.206'], ['B01.050.150.900.493.370.853.392'], ['B01.300.107.366', 'B01.300.381.355'], ['C22.362'], ['B01.050.150.900.493'], ['E01.370.350.515.402.541', 'E05.595.402.541'], ['B01.300.381'], ['C01.150.703']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
NO inhibits hyperoxia-induced NF-êB activation in neonatal pulmonary microvascular endothelial cells. | Inhaled NO (iNO) may be protective against hyperoxic injury in the premature lung, but the mechanism is unknown. We hypothesized that NO would prevent hyperoxia-induced nuclear factor kappa B (NF-êB) activation in neonatal pulmonary microvascular endothelial cells [human pulmonary microvascular endothelial cell (HPMEC)... | ['Caspase 3', 'Cell Proliferation', 'Cell Survival', 'Cells, Cultured', 'Endothelial Cells', 'Humans', 'Hyperoxia', 'I-kappa B Proteins', 'Infant, Newborn', 'Intercellular Adhesion Molecule-1', 'Lung', 'Microcirculation', 'NF-KappaB Inhibitor alpha', 'NF-kappa B', 'Nitric Oxide', 'Oxygen', 'Signal Transduction'] | 20,805,787 | [['D08.811.277.656.262.500.126.350.300', 'D08.811.277.656.300.200.126.350.300', 'D12.644.360.075.405.350.300', 'D12.776.476.075.405.350.300'], ['G04.161.750', 'G07.345.249.410.750'], ['G04.346'], ['A11.251'], ['A11.436.275'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.888.852.567'], ['D12.644.360.365', 'D12... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Named Groups [M]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
GluA1 subunit ubiquitination mediates amyloid-â-induced loss of surface á-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. | The accumulation of soluble amyloid-â (Aâ) peptides produces profound neuronal changes in the brain during the pathogenesis of Alzheimer's disease. Excessive levels of Aâ disrupt excitatory synaptic transmission by promoting the removal of synaptic AMPA receptors (AMPARs), dendritic spine loss, and synaptic depression.... | ['Amino Acid Substitution', 'Amyloid beta-Peptides', 'Animals', 'Cells, Cultured', 'Endosomal Sorting Complexes Required for Transport', 'Mutation, Missense', 'Nedd4 Ubiquitin Protein Ligases', 'Neurons', 'Peptide Fragments', 'Phosphorylation', 'Rats', 'Receptors, AMPA', 'Ubiquitin-Protein Ligases', 'Ubiquitination'] | 28,377,502 | [['E05.393.420.601.035', 'G05.558.109'], ['D12.644.024', 'D12.776.049.407.249.500', 'D12.776.543.039.500'], ['B01.050'], ['A11.251'], ['D05.500.199', 'D12.776.543.990.493'], ['G05.365.590.650'], ['D05.500.199.500', 'D08.811.464.938.750.257', 'D12.776.543.990.493.500'], ['A08.675', 'A11.671'], ['D12.644.541'], ['G02.111... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Tags and bands of the female external genitalia in the newborn infant. | A high incidence of hymenal tags (5.75%) and hymenal bands (2.7%) was found during the routine physical examination of 974 female infants within the first 24 hours of life. Hymenal tags usually disappear spontaneously as the estrogen effect diminishes. If they do not, biopsy should be considered. A simple test is propo... | ['Female', 'Humans', 'Hymen', 'Infant, Newborn', 'Prospective Studies'] | 6,822,016 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['A05.360.319.779.479', 'A10.615.550.368'], ['M01.060.703.520'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650']] | ['Organisms [B]', 'Anatomy [A]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Covalent crosslinking of tRNA1Val to 16S RNA at the ribosomal P site: identification of crosslinked residues. | N-Acetylvalyl-tRNA1Val (AcVal-tRNA1Val) was bound to the P site of uniformly 32P-labeled 70S ribosomes from Escherichia coli and crosslinked to 16S RNA in the 30S ribosomal subunit by irradiation with light of 300-400 nm. To identify the crosslinked nucleotide in 16S RNA. AcVal-tRNA1Val-16S [32P]RNA was digested comple... | ['Base Sequence', 'Chemical Phenomena', 'Chemistry', 'Electrophoresis, Polyacrylamide Gel', 'Escherichia coli', 'Nucleic Acid Conformation', 'Oligoribonucleotides', 'RNA, Ribosomal', 'RNA, Transfer, Amino Acyl', 'Ribonuclease T1', 'Ribosomes'] | 6,813,860 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G02'], ['H01.181'], ['E05.196.401.402', 'E05.301.300.319'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['G02.111.570.820.486', 'G05.360.580'], ['D13.695.578.424.500'], ['D13.444.735.686'], ['D12.125.780', 'D13.444.735.757.715'], ['D08.811.277.35... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Experimental hyperthyroidism III: Contractile responses to propranolol of the intact heart and of the isolated ventricular myocardium. | The effect of propranolol on cardiac mechanics and haemodynamics was examined on isolated papillary muscle as well as in situ in the closed thorax in euthyroid and hyperthyroid cats. Under propranolol there occurred on isolated papillary muscle significant decreases of muscle contraction, contraction velocity, isometri... | ['Aged', 'Animals', 'Blood Pressure', 'Cats', 'Disease Models, Animal', 'Dose-Response Relationship, Drug', 'Heart', 'Heart Ventricles', 'Hemodynamics', 'Humans', 'Hyperthyroidism', 'In Vitro Techniques', 'Middle Aged', 'Myocardial Contraction', 'Propranolol', 'Thyroxine'] | 1,156,309 | [['M01.060.116.100'], ['B01.050'], ['E01.370.600.875.249', 'G09.330.380.076'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['G07.690.773.875', 'G07.690.936.500'], ['A07.541'], ['A07.541.560'], ['G09.330.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C19.874... | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Dielectric relaxations in confined hydrated myoglobin. | In this work we report the results of a broadband dielectric spectroscopy study on the dynamics of a globular protein, myoglobin, in confined geometry, i.e. encapsulated in a porous silica matrix, at low hydration levels, where about only one or two water layers surround the proteins. In order to highlight the specific... | ['Animals', 'Electric Conductivity', 'Horses', 'Hydrogel, Polyethylene Glycol Dimethacrylate', 'Myoglobin', 'Silicon Dioxide', 'Spectrum Analysis', 'Temperature', 'Water'] | 19,537,774 | [['B01.050'], ['G01.358.500.249.277'], ['B01.050.150.900.649.313.984.235.472'], ['D02.033.455.250.700.485', 'D05.750.219.500', 'D05.750.741.485', 'D20.280.320.609.500', 'D25.720.532.500', 'D25.720.741.485', 'D26.255.165.320.375.375', 'J01.637.051.720.584.500', 'J01.637.051.720.741.485'], ['D12.776.210.500.588', 'D12.77... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Uterus-like Masses in a Rhesus Macaque (Macaca mulatta | Endometriosis is a relatively common condition in women and some populations of adult female rhesus macaques. However, endometriosis with extensive smooth muscle proliferation, as occurs in endomyometrioma and uterus-like mass (ULM), is rare in women. This report describes a case of endometriosis with extensive smooth ... | ['Animals', 'Biopsy', 'Cell Proliferation', 'Endometriosis', 'Endometrium', 'Female', 'Immunohistochemistry', 'Macaca mulatta', 'Metaplasia', 'Monkey Diseases', 'Muscle, Smooth', 'Ultrasonography'] | 28,830,586 | [['B01.050'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['G04.161.750', 'G07.345.249.410.750'], ['C13.351.500.163'], ['A05.360.319.679.490'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512',... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Nitric oxide mediates membrane depolarization-promoted survival of rat neuronal PC12 cells. | Membrane depolarization promotes neuronal survival through increases in intracellular calcium. Nitric oxide (NO) is a signaling molecule involved in many neuronal activity-dependent events. Since neuronal NO is generated by NO synthase (NOS) in a calcium-dependent manner and was shown to promote cell survival, we teste... | ['Animals', 'Cell Differentiation', 'Cell Membrane', 'Cell Survival', 'Cyclic GMP', 'Mitogen-Activated Protein Kinases', 'Neurons', 'Nitric Oxide', 'Nitric Oxide Donors', 'Nitric Oxide Synthase', 'Organophosphonates', 'PC12 Cells', 'Potassium', 'Rats', 'Transfection', 'ras Proteins'] | 12,812,842 | [['B01.050'], ['G04.152'], ['A11.284.149'], ['G04.346'], ['D03.633.100.759.646.454.160', 'D13.695.462.275', 'D13.695.667.454.160', 'D13.695.827.426.160'], ['D08.811.913.696.620.682.700.567', 'D12.644.360.450', 'D12.776.476.450'], ['A08.675', 'A11.671'], ['D01.339.387', 'D01.625.550.500', 'D01.625.700.500', 'D01.650.550... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A paradox: the 5-HT2-receptor antagonist ketanserin restores the 5-HT-induced contraction depressed by methysergide in large coronary arteries of calf. Allosteric regulation of 5-HT2-receptors. | Methysergide depresses the contractile effects of 5-hydroxytryptamine (5-HT) in bovine large coronary arteries devoid of endothelium. The IC50 of methysergide for depression of the response to 5-HT was (-log mol/l) 9.8. A low sensitivity contractile effect of 5-HT was not influenced by 1-1,000 nmol/l methysergide. The ... | ['Allosteric Regulation', 'Animals', 'Cattle', 'Coronary Vessels', 'In Vitro Techniques', 'Ketanserin', 'Methysergide', 'Models, Biological', 'Piperidines', 'Receptors, Serotonin', 'Serotonin', 'Serotonin Antagonists', 'Vasoconstriction'] | 3,157,064 | [['G02.111.044'], ['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['A07.015.114.269', 'A07.015.908.194'], ['E05.481'], ['D03.383.621.365', 'D03.633.100.786.830.333'], ['D03.132.327.287.689', 'D03.633.400.439.689'], ['E05.599.395'], ['D03.383.621'], ['D12.776.543.750.670.800', 'D12.776.543.750.695.800', 'D12.776.5... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Salivary mutans streptococci and lactobacilli levels after ingestion of the probiotic bacterium Lactobacillus reuteri ATCC 55730 by straws or tablets. | OBJECTIVE: Previous studies have suggested that lactobacilli-derived probiotics in dairy products may affect oral ecology, but the impact of different vehicles of ingestion has received little attention. The aim of the present study was to investigate the effect of the probiotic bacterium Lactobacillus reuteri ATCC 557... | ['Adult', 'Humans', 'Lactobacillus', 'Lactobacillus reuteri', 'Probiotics', 'Saliva', 'Streptococcus mutans', 'Water'] | 16,945,898 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B03.353.750.450.475', 'B03.510.460.400.410.475.475', 'B03.510.550.450.475'], ['B03.353.750.450.475.680', 'B03.510.460.400.410.475.475.680', 'B03.510.550.450.475.680'], ['G07.203.300.456.500', 'J02.500.456.500'], ['A12.200.666'], ['B03.353.750.737.872.... | ['Named Groups [M]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 |
Tropical sprue in two foreign residents, with evidence of Tropheryma whippelii in one case. | Tropical sprue is a rare disease in travelers. Its etiology remains unclear. We report two cases of tropical sprue occurring in long-term residents in Nepal and Cameroon. In one case, Tropheryma whippelii, the agent of Whipple's disease, was identified. Many infectious agents have been suggested to be the etiological a... | ['Actinobacteria', 'Anti-Bacterial Agents', 'Cameroon', 'Diagnosis, Differential', 'Female', 'Humans', 'Male', 'Middle Aged', 'Nepal', 'Sprue, Tropical', 'Travel', 'Whipple Disease'] | 16,706,950 | [['B03.510.024', 'B03.510.460.400.400.049'], ['D27.505.954.122.085'], ['Z01.058.290.100.110'], ['E01.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['Z01.252.245.674'], ['C06.405.469.637.850', 'C18.452.603.850'], ['I03.883'], ['C01.150.252.410.040.137.631', 'C06.405.469.637.925', 'C18.452.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 |
Functional residual capacity (FRC) does not predict response to surfactant in preterm infants. | We tested the hypothesis that the initial functional residual capacity (FRC) of preterm infants with hyaline membrane disease (HMD) could predict the response to surfactant replacement (Survanta, 4 mL/kg/dose), with a better initial FRC being correlated with a greater improvement in PaO2, a/A PO2 ratio, and FRC. Thirty... | ['Biological Products', 'Blood Gas Analysis', 'Dose-Response Relationship, Drug', 'Female', 'Functional Residual Capacity', 'Humans', 'Infant, Newborn', 'Infant, Premature', 'Lung', 'Male', 'Predictive Value of Tests', 'Pulmonary Surfactants', 'Treatment Outcome'] | 12,012,291 | [['D20.215'], ['E01.370.225.124.100.100', 'E01.370.386.700.100', 'E05.200.124.100.100'], ['G07.690.773.875', 'G07.690.936.500'], ['E01.370.386.700.485.750.275', 'G09.772.850.390'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['M01.060.703.520.520'], ['A04.411'], ['E05.318.370.800.650', 'N05.71... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Named Groups [M]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Glucose-6-phosphate dehydrogenase (G6PD) deficiency in southern Italy: a case of G6PD A(-) associated with favism. | During a routine screening for G6PD deficiency in the Province of Matera (Southern Italy), an eleven-year-old boy was brought to our attention who had fever obviously caused by a viral infection, but who also had hepatosplenomegaly and haemoglobinuria. The boy had previously experienced two severe haemolytic attacks. A... | ['Adolescent', 'Drug Combinations', 'Favism', 'Glucosephosphate Dehydrogenase', 'Glucosephosphate Dehydrogenase Deficiency', 'Hemolysis', 'Humans', 'Italy', 'Male', 'Sulfamethoxazole', 'Trimethoprim', 'Trimethoprim, Sulfamethoxazole Drug Combination', 'Virus Diseases'] | 2,498,187 | [['M01.060.057'], ['D26.310'], ['C15.378.071.141.150.480.370', 'C15.378.071.141.370', 'C16.320.070.480.370', 'C25.723.415.341', 'C25.723.756.375'], ['D08.811.682.047.150.300'], ['C15.378.071.141.150.480', 'C16.320.070.480', 'C16.320.565.202.402', 'C18.452.648.202.402'], ['C23.550.403', 'G12.122.545'], ['B01.050.150.900... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
Validity of Short and Long Self-Administered Food Frequency Questionnaires in Ranking Dietary Intake in Middle-Aged and Elderly Japanese in the Japan Public Health Center-Based Prospective Study for the Next Generation (JPHC-NEXT) Protocol Area. | BACKGROUND: Longitudinal epidemiological studies require both the periodic update of intake information via repeated dietary survey and the minimization of subject burden in responding to questionnaires. We developed a 66-item Food Frequency Questionnaire (short-FFQ) for the Japan Public Health Center-based prospective... | ['Adult', 'Aged', 'Diet', 'Diet Surveys', 'Female', 'Humans', 'Japan', 'Male', 'Middle Aged', 'Prospective Studies', 'Public Health', 'Reproducibility of Results'] | 27,064,130 | [['M01.060.116'], ['M01.060.116.100'], ['G07.203.650.240'], ['E05.318.308.980.485.350', 'N05.715.360.300.800.469.300', 'N06.850.505.616.300', 'N06.850.520.308.980.469.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.474.463', 'Z01.639.595'], ['M01.060.116.630'], ['E05.318.372.500.750.625', 'N05.715.360... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
ADAM10-Notch signaling governs the recruitment of ovarian pregranulosa cells and controls folliculogenesis in mice. | Ovarian follicles are the basic functional units of female reproduction in the mammalian ovary. We show here that the protein a disintegrin and metalloproteinase domain 10 (ADAM10), a cell surface sheddase, plays an indispensable role in controlling primordial follicle formation by regulating the recruitment of follicl... | ['ADAM10 Protein', 'Animals', 'Animals, Newborn', 'Cell Differentiation', 'Cell Proliferation', 'Female', 'Forkhead Box Protein L2', 'Forkhead Transcription Factors', 'Germ Cells', 'Granulosa Cells', 'Mice', 'Organogenesis', 'Receptors, G-Protein-Coupled', 'Receptors, Notch', 'Signal Transduction', 'Stem Cells'] | 27,084,580 | [['D08.811.277.656.675.374.102.250', 'D09.400.430.500.250', 'D12.776.395.033.250'], ['B01.050'], ['B01.050.050.282'], ['G04.152'], ['G04.161.750', 'G07.345.249.410.750'], ['D12.776.260.950.249.032', 'D12.776.930.977.249.032'], ['D12.776.260.950.249', 'D12.776.930.977.249'], ['A05.360.490', 'A11.497'], ['A05.360.319.114... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The cDNA sequence of the lactate dehydrogenase-A of the spiny dogfish (Squalus acanthias): corrections to the amino acid sequence and an analysis of the phylogeny of vertebrate lactate dehydrogenases. | The cDNA sequence of the lactate dehydrogenase-A (LDH-A) of the spiny dogfish was determined. The deduced amino acid sequence differed from a previously determined protein sequence by 5%. Separate maximum parsimony analyses of the two sequences along with LDHs of other vertebrates resulted in shorter trees with the seq... | ['Amino Acid Sequence', 'Animals', 'Artifacts', 'Base Sequence', 'Cloning, Molecular', 'DNA, Complementary', 'Dogfish', 'L-Lactate Dehydrogenase', 'Molecular Sequence Data', 'Multigene Family', 'Muscles', 'Phylogeny', 'Sequence Alignment', 'Sequence Analysis, DNA', 'Sequence Homology, Amino Acid', 'Vertebrates'] | 8,541,980 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['E05.047'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.393.220'], ['D13.444.308.497.220', 'D13.444.600.223.500', 'D27.720.470.530.600.223.260'], ['B01.050.150.900.493.370.853.392'], ['D08.811.682.047.551.400', 'D08.811.682.047.820.493'], [... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
[A case of cystic lymphangioma of the liver]. | Here is a case report about a cystic lymphangioma of the liver, a rare benign tumor, extremely difficult to diagnose with certainty in spite of the wide range of examinations today available. Surgical intervention is still the most important means to achieve the final diagnosis. The authors also provide a discussion ab... | ['Adult', 'Female', 'Humans', 'Liver', 'Liver Neoplasms', 'Lymphangioma'] | 2,097,569 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A03.620'], ['C04.588.274.623', 'C06.301.623', 'C06.552.697'], ['C04.557.375.450']] | ['Named Groups [M]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.