Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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High Mobility Group Protein B1 (HMGB1) and Interleukin-1â as Prognostic Biomarkers of Epilepsy in Children. | The present study examined whether serum biomarkers can predict the prognosis of childhood epilepsy, including seizure frequency, electroencephalographic (EEG) changes, and cognitive impairment. We measured serum concentrations of high mobility group protein B1 (HMGB1), interleukin-1â (IL-1â), S100 calcium-binding prot... | ['Adolescent', 'Child', 'Child, Preschool', 'Electroencephalography', 'Epilepsy', 'Female', 'Follow-Up Studies', 'Glial Fibrillary Acidic Protein', 'HMGB1 Protein', 'Humans', 'Infant', 'Infant, Newborn', 'Intelligence', 'Interleukin-1beta', 'Magnetic Resonance Imaging', 'Male', 'Retrospective Studies', 'S100 Calcium Bi... | 30,303,442 | [['M01.060.057'], ['M01.060.406'], ['M01.060.406.448'], ['E01.370.376.300', 'E01.370.405.245'], ['C10.228.140.490'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['D05.750.078.593.400', 'D12.776.220.475.400'], ['D12.776.260.356.300', 'D12.776.660.235.400.600.300', 'D12.776.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Electroretinographic responses in Lafora disease. | In 3 patients with Lafora disease specific ERGs were observed resembling closely those seen in the Schubert-Bronschein type of night blindness. In contrast to essential hemeralopia, where the b-wave is completely lacking a gradual recovery of the b-wave was recorded in Lafora disease. The recovery occurred within about... | ['Adolescent', 'Adult', 'Dark Adaptation', 'Electroretinography', 'Epilepsies, Myoclonic', 'Humans', 'Male', 'Night Blindness'] | 84,746 | [['M01.060.057'], ['M01.060.116'], ['G14.020.371'], ['E01.370.380.225', 'E01.370.405.270'], ['C10.228.140.490.375.130', 'C10.228.140.490.493.063'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C11.966.671']] | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
PINK1 deficiency attenuates astrocyte proliferation through mitochondrial dysfunction, reduced AKT and increased p38 MAPK activation, and downregulation of EGFR. | PINK1 (PTEN induced putative kinase 1), a familial Parkinson's disease (PD)-related gene, is expressed in astrocytes, but little is known about its role in this cell type. Here, we found that astrocytes cultured from PINK1-knockout (KO) mice exhibit defective proliferative responses to epidermal growth factor (EGF) and... | ['Animals', 'Astrocytes', 'Cattle', 'Cell Proliferation', 'Cells, Cultured', 'Down-Regulation', 'ErbB Receptors', 'Mice', 'Mice, 129 Strain', 'Mice, Inbred C57BL', 'Mice, Knockout', 'Mitochondria', 'Protein Kinases', 'Proto-Oncogene Proteins c-akt', 'Up-Regulation', 'p38 Mitogen-Activated Protein Kinases'] | 23,440,919 | [['B01.050'], ['A08.637.200', 'A11.650.200'], ['B01.050.150.900.649.313.500.380.271'], ['G04.161.750', 'G07.345.249.410.750'], ['A11.251'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['D08.811.913.696.620.682.725.400.009', 'D12.776.543.750.630.009', 'D12.776.543.750.750.400.074'], ['B01.050.150.900.649.313.992.... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Selective antitumor activity of roscovitine in head and neck cancer. | Radiation and chemotherapy that are commonly used to treat human cancers damage cellular DNA. DNA damage appears to be more toxic to cancer cells than normal cells, most likely due to deregulated checkpoint activation and/or deficiency in DNA repair pathways that are characteristics of many tumors. However, unwanted si... | ['Animals', 'Antineoplastic Agents', 'Female', 'Head and Neck Neoplasms', 'Humans', 'Mice', 'Mice, Nude', 'Papillomaviridae', 'Papillomavirus Infections', 'Protein Kinase Inhibitors', 'Purines', 'Roscovitine', 'Xenograft Model Antitumor Assays'] | 27,233,076 | [['B01.050'], ['D27.505.954.248'], ['C04.588.443'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.150.900.649.313.992.635.505.500.550.500'], ['B04.280.210.655', 'B04.613.204.655'], ['C01.925.256.650', 'C01.925.928.725'], ['D27.505.519.389.755'], ['D03.633.100.75... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Age-determined changes in the effects of a newly synthetized cholinesterase inhibitor on exploratory behavior, memory and striatal cholinesterase activity in rats. | The newly synthetized cholinesterase inhibitor C-8 (a structural analogue of physostigmine) at a dose of 4 mg.kg-1 exerted no inhibitory effect on the spontaneous locomotor activity in 2-, 10- and 22-month old male Wistar rats. Upon open field test, C-8 facilitated the process of habituation in the rats of all three gr... | ['Aging', 'Animals', 'Avoidance Learning', 'Cholinesterase Inhibitors', 'Cholinesterases', 'Corpus Striatum', 'Exploratory Behavior', 'Male', 'Memory', 'Motor Activity', 'Rats', 'Rats, Inbred Strains'] | 2,603,737 | [['G07.345.124'], ['B01.050'], ['F02.463.425.097', 'F02.463.785.373.173'], ['D27.505.519.389.275', 'D27.505.519.625.120.300', 'D27.505.696.577.120.300'], ['D08.811.277.352.100.170'], ['A08.186.211.200.885.287.249.487'], ['F01.145.387', 'F01.658.370'], ['F02.463.425.540'], ['F01.145.632', 'G11.427.410.698'], ['B01.050.1... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Memory consolidation during sleep: a neurophysiological perspective. | In the awake brain, information about the external world reaches the hippocampus via the entorhinal cortex, whereas during sleep the direction of information flow is reversed: population bursts initiated in the hippocampus invade the neocortex. We suggest that neocortico-hippocampal transfer of information and the modi... | ['Calcium', 'Dendrites', 'Hippocampus', 'Humans', 'Memory', 'Neuronal Plasticity', 'Sleep, REM', 'Synaptic Transmission'] | 9,682,189 | [['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['A08.675.256', 'A11.284.180.225', 'A11.671.240'], ['A08.186.211.180.405', 'A08.186.211.200.885.287.500.345'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.425.540'], ['G11.561.638'], ['F02.830.855.796.671', 'G11.561.803.754.671'], ['G02.111.820.850'... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Progesterone production and actions in the human central nervous system and neurogenic tumors. | Progesterone has been suggested to be involved in the functions of the nervous system, but it has yet to be examined in humans. Progesterone has also been postulated to be involved in the biological behavior of various human neurogenic tumors via progesterone receptors A and B (PR-A and PR-B). In this study we examined... | ['3-Hydroxysteroid Dehydrogenases', 'Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Astrocytoma', 'Brain', 'Brain Chemistry', 'Brain Neoplasms', 'Child', 'Cholesterol Side-Chain Cleavage Enzyme', 'Female', 'Gene Expression', 'Humans', 'Immunohistochemistry', 'Male', 'Meningioma', 'Middle Aged', 'Neurilemmoma', 'Ph... | 12,414,909 | [['D08.811.682.047.436.350'], ['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C04.557.465.625.600.380.080', 'C04.557.470.670.380.080', 'C04.557.580.625.600.380.080'], ['A08.186.211'], ['G02.111.150', 'G03.185'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['M01.060.4... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Building capacity for human genetics and genomics research in Trinidad and Tobago. | Advances in human genetics and genomic sciences and the corresponding explosion of biomedical technologies have deepened current understanding of human health and revolutionized medicine. In developed nations, this has led to marked improvements in disease risk stratification and diagnosis. These advances have also led... | ['Genetics, Medical', 'Genomics', 'Humans', 'Public Health', 'Trinidad and Tobago'] | 26,837,529 | [['H01.158.273.343.385.500', 'H02.403.350'], ['H01.158.273.180.350', 'H01.158.273.343.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H02.403.720', 'N01.400.550', 'N06.850'], ['Z01.107.084.900.900', 'Z01.639.880.900']] | ['Disciplines and Occupations [H]', 'Organisms [B]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
Morphological parameter variations between sister chromatids by electron microscopy. | Five morphological parameters of sister chromatids, viz radius, length, centromeric index, volume and centromere width, were studied by electron microscopy, from 140 human number 1 chromosomes, and 122 human number 2 chromosomes. The degree of variation obtained ranged from 0.277 +/- 0.003% and 0.286 +/- 0.005% for the... | ['Cells, Cultured', 'Chromatids', 'Chromosomes, Human', 'Chromosomes, Human, Pair 1', 'Chromosomes, Human, Pair 2', 'Humans', 'Lymphocytes'] | 3,568,758 | [['A11.251'], ['A11.284.430.106.279.345.190.160.175', 'G05.360.160.175'], ['A11.284.187.520.300', 'G05.360.162.520.300'], ['A11.284.187.520.300.235.240', 'G05.360.162.520.300.235.240'], ['A11.284.187.520.300.235.245', 'G05.360.162.520.300.235.245'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.118.637.555.567... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Possible involvement of PKC isoforms in signalling placental apoptosis in intrauterine growth retardation. | Apoptosis contributes to uteroplacental dsyfunction in intrauterine growth retardation (IUGR). Specific protein kinase C (PKC) isoforms regulate apoptosis in other cell types. PKC isoforms thought to be anti-apoptotic include the conventional PKC isoforms (cPKC-alpha, -beta I and -beta II), whereas the novel PKC isofor... | ['Animals', 'Apoptosis', 'Dexamethasone', 'Dose-Response Relationship, Drug', 'Female', 'Fetal Growth Retardation', 'Glucocorticoids', 'Isoenzymes', 'Placenta', 'Placenta Diseases', 'Pregnancy', 'Protein Kinase C', 'Rats', 'Rats, Wistar', 'Signal Transduction'] | 11,738,801 | [['B01.050'], ['G04.146.954.035'], ['D04.210.500.745.432.769.344', 'D04.210.500.908.238'], ['G07.690.773.875', 'G07.690.936.500'], ['C13.703.277.370', 'C16.300.390', 'C23.550.393.450'], ['D06.472.040.543', 'D27.505.696.399.472.488'], ['D08.811.348', 'D12.776.800.300'], ['A16.710'], ['C13.703.590'], ['G08.686.784.769'],... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Lysylated phospholipids stabilize models of bacterial lipid bilayers and protect against antimicrobial peptides. | Aminoacylated phosphatidylglycerols are common lipids in bacterial cytoplasmic membranes. Their presence in Staphylococcus aureus has been linked to increased resistance to a number of antibacterial agents, including antimicrobial peptides. Most commonly, the phosphatidylglycerol headgroup is esterified to lysine, whic... | ['Anti-Bacterial Agents', 'Anti-Infective Agents', 'Antimicrobial Cationic Peptides', 'Humans', 'Intercellular Signaling Peptides and Proteins', 'Lipid Bilayers', 'Lysine', 'Peptides', 'Phosphatidylglycerols', 'Phospholipids', 'Staphylococcus aureus'] | 24,780,374 | [['D27.505.954.122.085'], ['D27.505.954.122'], ['D12.644.050', 'D12.776.543.695.054'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276', 'D12.776.467', 'D23.529'], ['D10.570.510', 'J01.637.087.500.510'], ['D12.125.068.555', 'D12.125.095.647', 'D12.125.142.497'], ['D12.644'], ['D10.570.755.375.760.400.885... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Remodeling of the cardiovascular circulation in fetuses of mothers with diabetes: A fetal computational model analysis. | AIMS: Myocardial structural and functional abnormalities are known to occur in fetuses of mothers with diabetes mellitus (FMDM). The main aim of this investigation was to explore the cardiovascular circulatory patterns in FMDM using a validated lumped computational model of the cardiovascular system.METHODS: This was a... | ['Blood Flow Velocity', 'Cardiovascular System', 'Cross-Sectional Studies', 'Diabetes Mellitus', 'Female', 'Fetus', 'Humans', 'Middle Cerebral Artery', 'Models, Biological', 'Placenta', 'Pregnancy', 'Pregnancy in Diabetics', 'Ultrasonography, Prenatal', 'Umbilical Arteries', 'Vascular Remodeling'] | 29,486,850 | [['E01.370.370.130', 'G09.330.380.630.080'], ['A07'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['C18.452.394.750', 'C19.246'], ['A16.378'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A07.015.114.228.550'], ['E05.599.395'], ['A16.710'], ['G08.686.784.769'], ['C13.703.726'], ... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Prostanoid production in varicose veins: evidence for decreased prostacyclin with increased thromboxane A2 and prostaglandin E2 formation. | In this study, formation of arachidonic acid-derived prostanoids was investigated in saphenous veins of varicosed and nonvaricosed patients, all undergoing saphenectomy respectively for varicosis or in preparation for coronary bypass operation. Venous production of prostacyclin (PGI2), thromboxane A2 (TXA2) and prostag... | ['Dinoprostone', 'Epoprostenol', 'Female', 'Humans', 'Male', 'Middle Aged', 'Saphenous Vein', 'Thromboxane A2', 'Varicose Veins'] | 3,056,121 | [['D10.251.355.255.550.250.200', 'D23.469.050.175.725.250.200'], ['D10.251.355.255.550.550.500', 'D23.469.050.175.725.550.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['A07.015.908.819'], ['D10.251.355.255.100.825.800', 'D10.251.355.310.166.971.800'], ['C14.907.927']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Named Groups [M]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Accurate small and wide angle x-ray scattering profiles from atomic models of proteins and nucleic acids. | A new method is introduced to compute X-ray solution scattering profiles from atomic models of macromolecules. The three-dimensional version of the Reference Interaction Site Model (RISM) from liquid-state statistical mechanics is employed to compute the solvent distribution around the solute, including both water and ... | ['Molecular Dynamics Simulation', 'Muramidase', 'Myoglobin', 'Nucleic Acids', 'Proteins', 'Scattering, Small Angle', 'Water', 'X-Ray Diffraction'] | 25,494,779 | [['E05.599.595.500', 'G02.111.570.895', 'L01.224.160.500'], ['D08.811.277.450.642'], ['D12.776.210.500.588', 'D12.776.422.316.940'], ['D13.444'], ['D12.776'], ['E05.196.822.830', 'G01.867.755'], ['D01.045.250.875', 'D01.248.497.158.459.650', 'D01.650.550.925'], ['E05.196.309.742', 'E05.196.822.950', 'G01.867.950', 'G02... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Effects of dietary protein and fat contents on renal function and inflammatory cytokines in rats with adriamycin-induced nephrotic syndrome. | The effects of dietary protein and fat on renal function-related blood and urine parameters, such as albumin, urinary protein,and inflammatory cytokines were investigated in adriamycin- (ADR) induced nephrotic syndrome rats. ADR (2 mg/kg BW) was injected i.p. weekly for six weeks to develop nephrotic syndrome; thereaft... | ['Animals', 'Antibiotics, Antineoplastic', 'Body Weight', 'Creatinine', 'Cytokines', 'Dietary Fats', 'Dietary Proteins', 'Doxorubicin', 'Kidney', 'Lipid Metabolism', 'Male', 'Nephrotic Syndrome', 'Proteinuria', 'Rats', 'Rats, Sprague-Dawley'] | 21,822,358 | [['B01.050'], ['D27.505.954.248.106'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['D03.383.129.308.207'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['D10.212.302', 'G07.203.300.375', 'J02.500.375'], ['D12.776.256', 'G07.203.300.428'... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Purifying capability, enzyme activity, and nitrification potentials in December in integrated vertical flow constructed wetland with earthworms and different substrates. | The response of purifying capability, enzyme activity, nitrification potentials, and total number of bacteria in the rhizosphere in December to wetland plants, substrates, and earthworms was investigated in integrated vertical flow constructed wetlands (IVFCW). The removal efficiency of total nitrogen (TN), NH4-N, chem... | ['Animals', 'Biological Oxygen Demand Analysis', 'Biomass', 'Nitrification', 'Nitrogen', 'Oligochaeta', 'Phosphorus', 'Plants', 'Rhizosphere', 'Rivers', 'Seasons', 'Waste Water', 'Water Purification', 'Wetlands'] | 26,573,309 | [['B01.050'], ['N06.850.460.350.080.500', 'N06.850.780.375.349'], ['G16.500.275.157.100', 'N06.230.124.100'], ['G02.111.587.500', 'G02.607.560.500', 'G16.500.768.500'], ['D01.268.604', 'D01.362.625'], ['B01.050.500.091.657'], ['D01.268.666'], ['B01.650'], ['G16.500.275.157.625', 'G16.500.853', 'N06.230.124.437'], ['G01... | ['Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Augmentation of sensory-evoked hemodynamic response in an early Alzheimer's disease mouse model. | Based on enlarged blood oxygen level-dependent (BOLD) responses in cognitively normal subjects at risk for Alzheimer's disease (AD), compensatory neuronal hyperactivation has been proposed as an early marker for diagnosis of AD. The BOLD response results from neurovascular coupling, i.e., hemodynamic response induced b... | ['Alzheimer Disease', 'Animals', 'Cerebrovascular Circulation', 'Disease Models, Animal', 'Early Diagnosis', 'Electric Stimulation', 'Hemodynamics', 'Laser-Doppler Flowmetry', 'Male', 'Mice', 'Mice, Transgenic', 'Microscopy, Fluorescence, Multiphoton', 'Sensory Receptor Cells', 'Vasodilation'] | 23,948,921 | [['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['B01.050'], ['G09.330.100.159'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['E01.390'], ['E05.723.402'], ['G09.330.380'], ['E01.370.370.475', 'E05.830.500'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.136.500', 'B01.050.150.900.649.31... | ['Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Antithrombin III in fetuses and newborn children. | Antithrombin III (AT III) was measured in plasma of healthy fetuses between 20-29 weeks of gestation, in plasma of suspected growth retarded or malformed fetuses between 30-39 weeks of gestation, in healthy newborn infants after delivery, and in healthy infants during the first year of life. Measurements were performed... | ['Antithrombin III', 'Congenital Abnormalities', 'Female', 'Fetal Blood', 'Fetal Growth Retardation', 'Gestational Age', 'Humans', 'Infant, Newborn', 'Male', 'Pregnancy', 'Pregnancy Trimester, Third'] | 8,304,033 | [['D12.644.861.060.500', 'D12.776.124.790.106.125', 'D12.776.377.715.085.125', 'D12.776.872.060.500', 'D23.113.025'], ['C16.131'], ['A12.207.152.200', 'A15.145.300', 'A16.378.200'], ['C13.703.277.370', 'C16.300.390', 'C23.550.393.450'], ['G07.345.500.325.235.968', 'G08.686.320'], ['B01.050.150.900.649.313.988.400.112.4... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Named Groups [M]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Implementing a community-based falls-prevention program: from drawing board to reality. | Several studies have demonstrated the efficacy of falls-prevention programs designed for community-dwelling seniors using randomized designs. However, little is known about the feasibility of implementing these programs under natural conditions and about the success of these programs when delivered under such condition... | ['Accidental Falls', 'Aged', 'Aged, 80 and over', 'Exercise', 'Feasibility Studies', 'Female', 'Health Education', 'Health Promotion', 'Humans', 'Life Style', 'Male', 'Middle Aged', 'Postural Balance', 'Quebec', 'Risk Factors', 'Surveys and Questionnaires'] | 18,238,728 | [['N06.850.135.122'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['G11.427.410.698.277', 'I03.350'], ['E05.318.372.550', 'E05.337.675', 'N05.715.360.330.550', 'N06.850.520.450.550'], ['I02.233.332', 'N02.421.726.407'], ['I02.233.332.445', 'N02.421.726.407.579'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01... | ['Health Care [N]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Predictors of self-efficacy in women on long-term sick leave. | Self-efficacy has been shown to be related to sick leave and to be a predictor of return to work after sickness absence. The aim of this study was to investigate whether factors related to sick leave predict self-efficacy in women on long-term sick leave because of pain and/or mental illness. This cross-sectional study... | ['Adult', 'Chronic Pain', 'Cross-Sectional Studies', 'Female', 'Humans', 'Mental Disorders', 'Middle Aged', 'Motivation', 'Rehabilitation, Vocational', 'Return to Work', 'Self Efficacy', 'Sick Leave', 'Social Support', 'Surveys and Questionnaires', 'Sweden', 'Young Adult'] | 26,258,448 | [['M01.060.116'], ['C23.888.592.612.274'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F03'], ['M01.060.116.630'], ['F01.658', 'F01.752.543.500.750'], ['E02.760.169.063.500.782', 'E02.831.782', 'N02.421.784.644'], ['I03.946.449', 'N01... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
The influence of clips on scars after EMR: clip artifact. | BACKGROUND AND AIMS: Laterally spreading lesions ?20 mm are conventionally removed by EMR. Endoscopic clips are increasingly used to mitigate the risk of delayed bleeding. Clips may alter the endoscopic appearance of the scar after EMR, interfering with the assessment of adenoma recurrence. We aimed to evaluate this.ME... | ['Adenoma', 'Aged', 'Artifacts', 'Cicatrix', 'Colonoscopy', 'Colorectal Neoplasms', 'Endoscopic Mucosal Resection', 'Female', 'Humans', 'Male', 'Middle Aged', 'Narrow Band Imaging', 'Postoperative Hemorrhage', 'Prospective Studies', 'Surgical Instruments'] | 26,364,966 | [['C04.557.470.035'], ['M01.060.116.100'], ['E05.047'], ['A10.165.450.300', 'C23.550.355.274', 'G16.762.891.249'], ['E01.370.372.250.250.200', 'E01.370.388.250.250.250.160', 'E04.210.240.250.160', 'E04.502.250.250.250.160'], ['C04.588.274.476.411.307', 'C06.301.371.411.307', 'C06.405.249.411.307', 'C06.405.469.158.356'... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A complete mutational fitness map of the hepatitis C virus nonstructural 3 protease: relation to recognition by cytotoxic T lymphocytes. | The hepatitis C virus nonstructural (NS) 3/4A protease sequence is highly conserved for reasons not fully understood. We determined the protease activity in 181 NS3/4A gene products in which each protease residue was replaced by alanine or glycine. Unexpectedly, most (87%) protease residues could be replaced and protea... | ['Amino Acid Sequence', 'Amino Acid Substitution', 'Animals', 'Cysteine Endopeptidases', 'Epitopes', 'Genes, Viral', 'Genetic Variation', 'HLA-A2 Antigen', 'Hepacivirus', 'Hepatitis C', 'Humans', 'Mice', 'Mice, Transgenic', 'Molecular Sequence Data', 'Mutagenesis', 'Species Specificity', 'Spleen', 'T-Lymphocyte Subsets... | 17,109,345 | [['G02.111.570.060', 'L01.453.245.667.060'], ['E05.393.420.601.035', 'G05.558.109'], ['B01.050'], ['D08.811.277.656.262.500', 'D08.811.277.656.300.200'], ['D23.050.550'], ['G05.360.340.024.340.364.875', 'G05.360.340.358.024.875', 'G05.360.340.358.840.500'], ['G05.365'], ['D12.776.395.550.489.400.020', 'D12.776.543.550.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Anal papanicolaou smear in women with abnormal cytology: a thai hospital experience. | BACKGROUND: Anal intraepithelial lesions (AIL) are likely to represent a precursor for anal cancer. Women infected with human immunodeficiency virus (HIV) may be at higher risk of anal cancer but a screening program for AIL still is not routinely recommended. We here studied the relationship of dysplastic cells from ce... | ['Adult', 'Aged', 'Anal Canal', 'Anus Neoplasms', 'Carcinoma, Squamous Cell', 'Cytodiagnosis', 'Female', 'Follow-Up Studies', 'HIV', 'HIV Infections', 'Humans', 'Middle Aged', 'Neoplasm Staging', 'Papanicolaou Test', 'Prognosis', 'Prospective Studies', 'Risk Factors', 'Specimen Handling', 'Thailand', 'Young Adult'] | 25,735,369 | [['M01.060.116'], ['M01.060.116.100'], ['A03.556.124.526.070', 'A03.556.249.249.070'], ['C04.588.274.476.411.307.790.040', 'C06.301.371.411.307.790.040', 'C06.405.249.411.307.790.040', 'C06.405.469.491.307.790.040', 'C06.405.469.860.101.163', 'C06.405.469.860.180.500.040'], ['C04.557.470.200.400', 'C04.557.470.700.400'... | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
A New Method for Detecting Associations with Rare Copy-Number Variants. | Copy number variants (CNVs) play an important role in the etiology of many diseases such as cancers and psychiatric disorders. Due to a modest marginal effect size or the rarity of the CNVs, collapsing rare CNVs together and collectively evaluating their effect serves as a key approach to evaluating the collective effe... | ['DNA Copy Number Variations', 'Genetic Heterogeneity', 'Genetic Predisposition to Disease', 'Genome-Wide Association Study', 'Humans', 'Models, Theoretical', 'Polymorphism, Single Nucleotide', 'Schizophrenia'] | 26,431,523 | [['G05.365.795.297.500'], ['G05.365.331'], ['C23.550.291.687.500', 'G05.380.355'], ['E05.318.370.392', 'E05.318.416.249', 'E05.393.385.500', 'E05.393.522.500', 'E05.393.760.640.500', 'N06.850.520.445.392', 'N06.850.520.470.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599'], ['G05.365.795.598'], ['F03.7... | ['Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Myeloid differentiation factor 88-independent Toll-like receptor pathway: Sustaining inflammation or promoting tolerance? | Toll-like receptor signaling represents a principal molecular pathway for host innate immunity. Mechanistically, it can be segregated into two distinct cascades: the myeloid differentiation factor 88-dependent and myeloid differentiation factor 88-independent (or Toll receptor-associated activator of interferon-mediate... | ['Animals', 'Humans', 'Immune Tolerance', 'Inflammation', 'Myeloid Differentiation Factor 88', 'Signal Transduction', 'Toll-Like Receptors'] | 17,572,133 | [['B01.050'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G12.535.425'], ['C23.550.470'], ['D12.644.360.024.311', 'D12.776.157.057.074', 'D12.776.476.024.390'], ['G02.111.820', 'G04.835'], ['D12.776.543.750.705.910.500']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Comparison of lidocaine by fluorescence polarization immunoassay, enzyme immunoassay, and high resolution gas chromatography. | Lidocaine levels in plasma for therapeutic monitoring purposes were compared by using fluorescence polarization immunoassay (Abbott TDx), enzyme immunoassay (EMIT-Cad), and a high-resolution gas chromatography (HRGC). The two immunoassay methods on 29 clinical samples gave excellent correlation (r = 0.998 and 0.999 for... | ['Chromatography, Gas', 'Fluorescence Polarization', 'Humans', 'Immunoenzyme Techniques', 'Lidocaine'] | 3,298,856 | [['E05.196.181.349'], ['E05.196.712.516.600.390'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.478.566.350', 'E05.478.583.400', 'E05.601.470.350'], ['D02.065.199.092.500', 'D02.092.146.113.092.500']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Epidemiologic Trends of Chemical Ocular Burns in the United States. | Importance: Determining the national epidemiologic trends of chemical ocular burns can assist physicians and policy makers in appropriate allocation of resources for treatment and prevention.Objective: To describe the epidemiologic trends and risk factors for chemical burns of the eye.Design, Setting, and Participants:... | ['Adolescent', 'Adult', 'Age Factors', 'Aged', 'Burns, Chemical', 'Child', 'Child, Preschool', 'Emergency Service, Hospital', 'Eye Burns', 'Female', 'Follow-Up Studies', 'Humans', 'Incidence', 'Infant', 'Male', 'Middle Aged', 'Retrospective Studies', 'Risk Assessment', 'Risk Factors', 'Sex Factors', 'United States', 'Y... | 27,490,908 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['C26.200.156'], ['M01.060.406'], ['M01.060.406.448'], ['N02.278.216.500.968.336', 'N02.421.297.195', 'N04.452.442.452.422.336'], ['C10.900.300.284.250.250', 'C26.200.503', 'C26.915.300.425.250.250'], ['E05.318.372.500.750.2... | ['Named Groups [M]', 'Health Care [N]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
An international comparison of cancer survival: relatively poor areas of Toronto, Ontario and three US metropolitan areas. | BACKGROUND: This study of cancer survival compared adults in Toronto, Ontario and three US metropolitan areas: Seattle, Washington; San Francisco, California; and Hartford, Connecticut. It examined whether socioeconomic status has a differential effect on cancer survival in Canada and the United States.METHODS: The Ont... | ['Censuses', 'Cities', 'Connecticut', 'Cross-Cultural Comparison', 'Female', 'Humans', 'Male', 'Neoplasms', 'Ontario', 'Poverty Areas', 'Registries', 'SEER Program', 'San Francisco', 'Sex Distribution', 'Socioeconomic Factors', 'Survival Analysis', 'Urban Population', 'Washington'] | 11,077,908 | [['I01.240.205', 'N01.224.175', 'N06.850.505.400.225'], ['G16.500.275.069', 'N06.230.069', 'Z01.433'], ['Z01.107.567.875.550.200'], ['I01.076.201.450.281', 'I01.880.853.100.257'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04'], ['Z01.107.567.176.639'], ['I01.880.853.996.535.550', 'N01.824.600.550'], ['E05.318... | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
A study of chimeras constructed with the two domains of angiotensin I-converting enzyme. | Angiotensin I-converting enzyme (ACE) is composed of two highly similar domains called the N and C domains, which display some contrasting enzymatic properties. We constructed two ACE chimeras: chimera 1, comprised of the N domain containing the central 60 amino acid residues of the C domain, and chimera 2, comprised o... | ['Amino Acid Sequence', 'Humans', 'Molecular Sequence Data', 'Oligopeptides', 'Peptidyl-Dipeptidase A', 'Recombinant Fusion Proteins', 'Structure-Activity Relationship', 'Substrate Specificity'] | 8,534,262 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.453.245.667'], ['D12.644.456'], ['D08.811.277.656.350.350.687'], ['D12.776.828.300'], ['G02.111.830', 'G07.690.773.997'], ['G02.111.835']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
PDK1 is a potential therapeutic target against angiosarcoma cells. | BACKGROUND: Angiosarcoma is a rare and aggressive malignant neoplasm of endothelial cells. Recent studies have shown that the mTOR pathway is also aberrantly activated in cutaneous angiosarcoma. New therapeutic strategies are required because the prognosis of this disease is still poor.OBJECTIVE: The aim of the present... | ['3-Phosphoinositide-Dependent Protein Kinases', 'Antineoplastic Agents', 'Apoptosis', 'Cell Line, Tumor', 'Cell Proliferation', 'Cyclin D', 'Dose-Response Relationship, Drug', 'G1 Phase Cell Cycle Checkpoints', 'Hemangiosarcoma', 'Humans', 'Molecular Targeted Therapy', 'Phosphatidylinositol 3-Kinase', 'Phosphoinositid... | 25,726,712 | [['D08.811.913.696.620.682.700.745'], ['D27.505.954.248'], ['G04.146.954.035'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.161.750', 'G07.345.249.410.750'], ['D12.644.360.262.150', 'D12.776.167.218.150', 'D12.776.476.262.150'], ['G07.690.773.875', 'G07.690.936.500'], ['G04.144.109.249', 'G04.144.500.320.500'], ['C04... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Connexin43 deficiency causes delayed ossification, craniofacial abnormalities, and osteoblast dysfunction. | Connexin(Cx)43 is the major gap junction protein present in osteoblasts. We have shown that overexpression of Cx45 in osteoblasts expressing endogenous Cx43 leads to decreased cell-cell communication (Koval, M., S.T. Geist, E.M. Westphale, A.E. Kemendy, R. Civitelli, E.C. Beyer, and T.H. Steinberg. 1995. J. Cell Biol. ... | ['Animals', 'Bone and Bones', 'Cell Division', 'Connexin 43', 'Craniofacial Abnormalities', 'Embryonic and Fetal Development', 'Genotype', 'Gestational Age', 'Mice', 'Mice, Inbred C57BL', 'Mice, Inbred Strains', 'Mice, Knockout', 'Neural Crest', 'Osteoblasts', 'Osteogenesis', 'Reverse Transcriptase Polymerase Chain Rea... | 11,076,975 | [['B01.050'], ['A02.835.232', 'A10.165.265'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['D12.776.543.585.250.200'], ['C05.660.207', 'C16.131.621.207'], ['G07.345.500.325', 'G08.686.784.170'], ['G05.380'], ['G07.345.500.325.235.968', 'G08.686.320'], ['B01.050.150.900.649.313.992.635.505.... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Improving gene annotation of complete viral genomes. | Gene annotation in viruses often relies upon similarity search methods. These methods possess high specificity but some genes may be missed, either those unique to a particular genome or those highly divergent from known homologs. To identify potentially missing viral genes we have analyzed all complete viral genomes c... | ['Amino Acid Sequence', 'Computational Biology', 'Databases, Genetic', 'Genes, Viral', 'Genome, Viral', 'Herpesviridae', 'Humans', 'Molecular Sequence Data', 'Sensitivity and Specificity', 'Sequence Alignment', 'Software', 'Viral Proteins'] | 14,627,837 | [['G02.111.570.060', 'L01.453.245.667.060'], ['H01.158.273.180', 'L01.313.124'], ['L01.313.500.750.300.188.400.325', 'L01.470.750.750.325'], ['G05.360.340.024.340.364.875', 'G05.360.340.358.024.875', 'G05.360.340.358.840.500'], ['G05.360.340.358.840'], ['B04.280.382'], ['B01.050.150.900.649.313.988.400.112.400.400'], [... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
A quadricuspid aortic valve with atrial septal defect. | A quadricuspid aortic valve (QAV) is a rare congenital heart defect, previously described as an incidental finding at the time of surgery or postmortem, which is now being increasingly detected by 2D transthoracic or transesophageal echocardiogram. With advances in echocardiography, secondary cardiac anomalies are also... | ['Adolescent', 'Aortic Valve', 'Aortic Valve Insufficiency', 'Bundle-Branch Block', 'Contrast Media', 'Echocardiography, Doppler, Color', 'Echocardiography, Transesophageal', 'Electrocardiography', 'Heart Septal Defects, Atrial', 'Humans', 'Hypertrophy, Left Ventricular', 'Hypertrophy, Right Ventricular', 'Male'] | 17,069,606 | [['M01.060.057'], ['A07.541.510.110'], ['C14.280.484.048.500'], ['C14.280.067.558.323', 'C14.280.123.500.323', 'C23.550.073.425.100'], ['D27.505.259.500', 'D27.720.259'], ['E01.370.350.130.750.220.220', 'E01.370.350.850.220.220.220', 'E01.370.350.850.850.220.220', 'E01.370.350.850.850.850.850.220', 'E01.370.370.380.220... | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Single-beam homodyne SPIDER for multiphoton microscopy. | We report a new version of spectral phase interferometry for direct electric field reconstruction (SPIDER) requiring only a single phase-shaped laser beam. A narrowband probe pulse is selected out of a broadband ultrafast laser pulse by a phase pulse-shaping technique and mixed with the original broadband pulse to gene... | ['Algorithms', 'Image Enhancement', 'Image Interpretation, Computer-Assisted', 'Interferometry', 'Lasers', 'Microscopy, Fluorescence, Multiphoton', 'Reproducibility of Results', 'Sensitivity and Specificity'] | 18,594,646 | [['G17.035', 'L01.224.050'], ['E01.370.350.600.350', 'L01.224.308.380'], ['E01.158.600', 'E01.370.350.350', 'L01.313.500.750.100.158.600'], ['E05.490'], ['E07.632.490', 'E07.710.520'], ['E01.370.350.515.458.500', 'E01.370.350.515.717.250', 'E05.595.458.500', 'E05.595.717.250'], ['E05.318.370.725', 'E05.337.851', 'N05.7... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Activation of murine macrophages by silica particles in vitro is a process independent of silica-induced cell death. | We have tested the murine macrophagic cell line RAW 264.7 for its ability to undergo activation after exposure to silica particles in vitro. When exposed to silica under controlled conditions (each cell having access to about 10 silica particles), RAW 264.7 cells were able to phagocytose the particles. Concomitantly, t... | ['Animals', 'Cell Death', 'Cell Line', 'Gene Expression', 'Interferon-gamma', 'Lipopolysaccharides', 'Macrophage Activation', 'Macrophages, Peritoneal', 'Mice', 'Nitric Oxide', 'Phagocytosis', 'Silicon Dioxide', 'Silicosis', 'Tumor Necrosis Factor-alpha'] | 7,576,690 | [['B01.050'], ['G04.146'], ['A11.251.210'], ['G05.297'], ['D12.644.276.374.440.893', 'D12.644.276.374.480.615.350', 'D12.776.467.374.440.893', 'D12.776.467.374.480.615.350', 'D23.529.374.440.893', 'D23.529.374.480.615.350'], ['D09.400.500', 'D09.698.718.450', 'D10.494', 'D23.050.161.616.525', 'D23.946.123.329.500'], ['... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Monitoring the crystallization of starch and lipid components of the cake crumb during staling. | Cake staling is a complex problem which has still not been fully understood. Starch polymers retrogradation, which is linked to biopolymers recrystallisation, is the most important factor affecting cake firmness in addition to water migration and fat crystallization. In this study, the effect of storage temperatures of... | ['Amylopectin', 'Amylose', 'Bread', 'Crystallization', 'Food Storage', 'Lipids', 'Starch', 'Temperature'] | 26,344,311 | [['D09.301.915.194', 'D09.698.365.855.194'], ['D09.301.915.361', 'D09.698.365.855.361'], ['G07.203.300.100', 'J02.500.100'], ['E05.196.300', 'G02.171'], ['J01.576.423.200.387'], ['D10'], ['D05.750.078.562.855', 'D09.301.915', 'D09.698.365.855'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Human and avian influenza viruses target different cells in the lower respiratory tract of humans and other mammals. | Viral attachment to the host cell is critical for tissue and species specificity of virus infections. Recently, pattern of viral attachment (PVA) in human respiratory tract was determined for highly pathogenic avian influenza virus of subtype H5N1. However, PVA of human influenza viruses and other avian influenza virus... | ['Animals', 'Birds', 'Cats', 'Ferrets', 'Humans', 'Influenza A virus', 'Influenza in Birds', 'Influenza, Human', 'Macaca', 'Mice', 'Respiratory System', 'Species Specificity', 'Swine', 'Virus Attachment'] | 17,717,141 | [['B01.050'], ['B01.050.150.900.248'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['B01.050.150.900.649.313.750.250.575.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B04.820.480.968.405.400'], ['C01.925.782.620.300', 'C22.131.450'], ['C01.748.310', 'C01.925.782.620.365', 'C08.730.310'], ['B01.050.150.... | ['Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Wastewater discharge and water quality standards in Brazil--implications for the selection of wastewater treatment technologies. | The paper describes and comments the Brazilian standards for water quality and effluent discharge (CONAMA Directive No. 20, 1986). The emphasis of the paper is on the conventional parameters which characterise domestic wastewater (BOD, SS, NH4+, N, P and coliforms). The wastewater treatment systems for achieving compli... | ['Brazil', 'Developing Countries', 'Humans', 'Waste Disposal, Fluid', 'Water Microbiology', 'Water Pollutants, Chemical', 'Water Purification', 'Water Supply'] | 10,842,806 | [['Z01.107.757.176'], ['I01.615.500.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N06.850.780.200.800.800.890', 'N06.850.860.510.900.600.900'], ['H01.158.273.540.274.777', 'N06.850.425.450'], ['D27.888.284.903.655'], ['N06.850.780.200.800.800.900.900', 'N06.850.860.510.900.900'], ['J01.293.821.500']] | ['Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 1 |
Nutrient transport in a restored riparian wetland. | We determined the water quality effect of a restored forested riparian wetland adjacent to a manure application area and a heavily fertilized pasture in the Georgia Coastal Plain. The buffer system was managed based on USDA recommendations and averaged 38 m in width. Water quality and hydrology data were collected from... | ['Conservation of Natural Resources', 'Ecosystem', 'Environmental Monitoring', 'Manure', 'Nitrogen', 'Phosphorus', 'Solubility', 'Trees', 'Water Movements'] | 12,708,697 | [['J01.256', 'N06.230.080'], ['G16.500.275.157', 'N06.230.124'], ['N06.850.460.350.080', 'N06.850.780.375'], ['D20.601'], ['D01.268.604', 'D01.362.625'], ['D01.268.666'], ['G02.805'], ['B01.650.915'], ['G16.500.971', 'N06.230.132.644.750', 'N06.230.850']] | ['Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Prednisolone interferes with neutrophil adhesion and neutrophil mediated endothelial injury. | Adhesion of leukocytes to vascular endothelium is a crucial step in inflammation. This interaction may result in damage of the endothelial cells (EC). We evaluated the effects of prednisolone on adhesive interactions between human polymorphonuclear neutrophil granulocytes (PMN) and human umbilical vein endothelial cell... | ['Anti-Inflammatory Agents, Non-Steroidal', 'Calcimycin', 'Cell Adhesion', 'Cell Survival', 'Cells, Cultured', 'Endothelium, Vascular', 'Humans', 'Hydroxyeicosatetraenoic Acids', 'Lipoxins', 'N-Formylmethionine Leucyl-Phenylalanine', 'Neutrophils', 'Prednisolone', 'Umbilical Veins'] | 10,568,428 | [['D27.505.696.663.850.014.040.500', 'D27.505.954.158.030', 'D27.505.954.329.030'], ['D03.633.100.221.173'], ['G04.022'], ['G04.346'], ['A11.251'], ['A07.015.700.500', 'A10.272.491.355'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D10.251.355.255.100.300', 'D10.251.355.310.166.550'], ['D10.251.355.255.375'], ['... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
What best protects the inverted weightbearing ankle against further inversion? Evertor muscle strength compares favorably with shoe height, athletic tape, and three orthoses. | We measured the maximal isometric eversion moment developed under full weightbearing in 20 healthy adult men (age, 24.4 +/- 3.4 years; mean +/- SD) with their ankles in 15 degrees of inversion. Tests were performed at both 0 degree and 32 degrees of ankle plantar flexion in low- and in three-quarter-top shoes with and ... | ['Adult', 'Ankle Injuries', 'Ankle Joint', 'Biomechanical Phenomena', 'Female', 'Humans', 'Male', 'Muscle, Skeletal', 'Orthotic Devices', 'Protective Devices', 'Shoes', 'Weight-Bearing'] | 8,947,403 | [['M01.060.116'], ['C26.558.100'], ['A02.835.583.378.062'], ['G01.154.090', 'G01.374.089'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.633.567', 'A10.690.552.500'], ['E07.858.442.743'], ['E07.700', 'J01.637.708'], ['J01.637.215.800'], ['G01.374.965']] | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 |
Computerised pathology test order entry reduces laboratory turnaround times and influences tests ordered by hospital clinicians: a controlled before and after study. | OBJECTIVE: To assess the impact of a computerised pathology order entry system on laboratory turnaround times and test ordering within a teaching hospital.METHODS: A controlled before and after study compared test assays ordered from 11 wards two months before (n = 97 851) and after (n = 113 762) the implementation of ... | ['Chi-Square Distribution', 'Clinical Laboratory Information Systems', 'Clinical Laboratory Techniques', 'Hospitals, Teaching', 'Humans', 'Laboratories, Hospital', 'Medical Records Systems, Computerized', 'Time Management'] | 16,461,564 | [['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['N04.452.515.080'], ['E01.370.225', 'E05.200'], ['N02.278.020.300', 'N02.278.421.639'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N02.278.216.500.968.420', 'N02.278.487.410', 'N04.452.442.452.422.420'], ['E05.318.30... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Information Science [L]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Transabdominal ultrasound measurement of the lumbar spinal canal. Its value for evaluation of lumbar spinal stenosis. | Lumbar spinal stenosis, most commonly caused by hypertrophic changes in the soft tissues of the spinal canal, is itself a clinical entity, but in the early phase it can also serve as a factor influencing general back disorder morbidity. It can be identified reliably by measuring the anteroposterior diameter of the dura... | ['Abdomen', 'Adult', 'Female', 'Humans', 'Lumbosacral Region', 'Male', 'Middle Aged', 'Myelography', 'Sensitivity and Specificity', 'Spinal Canal', 'Spinal Stenosis', 'Tomography, X-Ray Computed', 'Ultrasonography'] | 2,646,739 | [['A01.923.047'], ['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A01.923.176.519'], ['M01.060.116.630'], ['E01.370.350.578.937.505', 'E01.370.350.700.560.505', 'E01.370.376.537.750.505', 'E05.629.937.505'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700', 'N05.715.360.750.72... | ['Anatomy [A]', 'Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Investigation of the p.Ser278Arg polymorphism of the autoimmune regulator (AIRE) gene in alopecia areata. | A recent study has suggested that the g.961C >G (p.Ser278Arg) variant of the autoimmune regulator (AIRE) gene contributes to susceptibility to alopecia areata (AA). We attempted to replicate this finding using a case-control sample of Belgian-German origin (273 patients and 283 controls). Despite adequate power, our st... | ['Alleles', 'Alopecia Areata', 'Case-Control Studies', 'European Continental Ancestry Group', 'Gene Frequency', 'Genetic Variation', 'Humans', 'Polymorphism, Genetic', 'Severity of Illness Index', 'Transcription Factors'] | 16,774,540 | [['G05.360.340.024.340.030'], ['C17.800.329.937.122.147'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['M01.686.508.400'], ['G05.330'], ['G05.365'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G05.365.795'], ['E05.318.308.980.438.475.456.500', 'N05.715.360.300.800.438.375.364.... | ['Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Named Groups [M]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Coordinated control of lumen size and collective migration in the salivary gland. | The Drosophila embryonic salivary gland is a powerful system to analyze the cellular and molecular mechanisms of tubulogenesis in vivo. The secretory portion of the salivary gland (referred to here as the salivary gland), is a pair of elongated epithelial tubes with a single central lumen, that is formed by the invagin... | ['Animals', 'Body Patterning', 'Cell Movement', 'Drosophila', 'Drosophila Proteins', 'Salivary Glands', 'rho GTP-Binding Proteins'] | 22,688,086 | [['B01.050'], ['G07.345.500.100'], ['G04.198', 'G07.568.500.180'], ['B01.050.500.131.617.720.500.500.750.310.250'], ['D12.776.093.500.462'], ['A03.556.500.760', 'A10.336.779', 'A14.549.760'], ['D08.811.277.040.330.300.400.700', 'D12.644.360.525.700', 'D12.776.157.325.515.700', 'D12.776.476.525.700']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Novel loci interacting epistatically with bone morphogenetic protein receptor 2 cause familial pulmonary arterial hypertension. | BACKGROUND: Familial pulmonary arterial hypertension (FPAH) is a rare, autosomal-dominant, inherited disease with low penetrance. Mutations in the bone morphogenetic protein receptor 2 (BMPR2) have been identified in at least 70% of FPAH patients. However, the lifetime penetrance of these BMPR2 mutations is 10% to 20%,... | ['Bone Morphogenetic Protein Receptors, Type II', 'Genetic Loci', 'Genotype', 'Humans', 'Hypertension, Pulmonary', 'Pedigree', 'Risk Factors'] | 19,864,167 | [['D08.811.913.696.620.682.700.109.750', 'D12.776.543.750.750.400.049.750'], ['G05.360.340.024.380'], ['G05.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C08.381.423', 'C14.907.489.556'], ['E05.393.673'], ['E05.318.740.600.800.725', 'N05.715.350.200.700', 'N05.715.360.750.625.700.700', 'N06.850.490.625.750'... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Sparfloxacin in the treatment of leprosy patients. | Seven men (age range, 20-33 years) with leprosy visited our dermatologic clinic at Yokohama City University Hospital (Table 1) and were entered into a trial of sparfloxacin (SPFX), 100-200 mg daily for up to 1 year. Five patients were Japanese Brazilians or Paraguayan from South America, and two patients were Filipinos... | ['Adult', 'Anti-Infective Agents', 'Biopsy', 'Fluoroquinolones', 'Follow-Up Studies', 'Humans', 'Leprosy', 'Male', 'Quinolones', 'Retrospective Studies', 'Skin', 'Treatment Outcome'] | 9,329,897 | [['M01.060.116'], ['D27.505.954.122'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['D03.633.100.810.835.322'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The respiratory effects of the cytokine regulating agent HP 228 alone and in combination with morphine in human volunteers. | HP 228 is a synthetic heptapeptide analog of alpha-MSH that attenuates the production and release of inflammatory cytokines. The purpose of this study was to define HP 228's effects, alone and in combination with morphine, on resting ventilation and the ventilatory response to hypoxia and hypercarbia. Six healthy nonsm... | ['Adult', 'Blood Pressure', 'Carbon Dioxide', 'Dose-Response Relationship, Drug', 'Enzyme Induction', 'Female', 'Heart Rate', 'Humans', 'Male', 'Morphine', 'Narcotics', 'Oligopeptides', 'Oxygen', 'Respiratory Mechanics'] | 9,512,083 | [['M01.060.116'], ['E01.370.600.875.249', 'G09.330.380.076'], ['D01.200.200', 'D01.362.150', 'D01.650.550.200'], ['G07.690.773.875', 'G07.690.936.500'], ['G05.308.320.200'], ['E01.370.600.875.500', 'G09.330.380.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.132.577.249.562.571', 'D03.605.497.607.587', 'D... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Rapid HIV-1 testing during labor: a multicenter study. | CONTEXT: Timely testing of women in labor with undocumented human immunodeficiency virus (HIV) status could enable immediate provision of antiretroviral prophylaxis.OBJECTIVES: To determine the feasibility and acceptance of rapid HIV testing among women in labor and to assess rapid HIV assay performance.DESIGN, SETTING... | ['AIDS Serodiagnosis', 'Adult', 'Antibodies, Viral', 'Delivery, Obstetric', 'Female', 'HIV Infections', 'HIV-1', 'Humans', 'Labor, Obstetric', 'Predictive Value of Tests', 'Pregnancy', 'Pregnancy Complications, Infectious', 'Sensitivity and Specificity'] | 15,249,571 | [['E01.370.225.812.735.060', 'E01.370.225.875.408.500', 'E05.200.812.735.060', 'E05.200.875.408.500', 'E05.478.594.760.060'], ['M01.060.116'], ['D12.776.124.486.485.114.254', 'D12.776.124.790.651.114.254', 'D12.776.377.715.548.114.254'], ['E04.520.252'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C0... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Effect of time delay and storage temperature on blood gas and acid-base values of bovine venous blood. | The aim of this study was to investigate possible changes in the gas composition and acid-base values of bovine venous blood samples stored at different temperatures (+4, 22 and 37 degrees C) for up to 48 h. Five healthy cattle were used in the study. A total of 15 blood samples collected from the animals were allocate... | ['Animals', 'Blood Gas Analysis', 'Blood Preservation', 'Carbon Dioxide', 'Cattle', 'Erythrocyte Count', 'Hemoglobins', 'Hydrogen-Ion Concentration', 'Leukocyte Count', 'Oxygen', 'Specimen Handling'] | 14,672,854 | [['B01.050'], ['E01.370.225.124.100.100', 'E01.370.386.700.100', 'E05.200.124.100.100'], ['E02.792.833.230', 'E05.760.833.230'], ['D01.200.200', 'D01.362.150', 'D01.650.550.200'], ['B01.050.150.900.649.313.500.380.271'], ['E01.370.225.500.195.107.330', 'E01.370.225.625.107.330', 'E05.200.500.195.107.330', 'E05.200.625.... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Deletion diagnostics for alternating logistic regressions. | Deletion diagnostics are introduced for the regression analysis of clustered binary outcomes estimated with alternating logistic regressions, an implementation of generalized estimating equations (GEE) that estimates regression coefficients in a marginal mean model and in a model for the intracluster association given ... | ['Cluster Analysis', 'Female', 'Humans', 'Logistic Models', 'Male', 'Primary Health Care', 'Probability', 'Time Factors'] | 22,777,960 | [['E05.318.740.250', 'N05.715.360.750.200', 'N06.850.520.830.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.525', 'E05.318.740.600.800.450', 'E05.318.740.750.450', 'E05.599.835.875', 'N05.715.360.750.530.480', 'N05.715.360.750.625.700.450', 'N05.715.360.750.695.470', 'N06.850.520.830.500.525'... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Nonrandom F-plasmid replication in Escherichia coli K-12. | Both the autonomous and chromosomally integrated F plasmids were found to replicate in a nonrandom fashion after a density transfer from heavy medium ([13C]glucose, 15NH4) to light medium ([12C]glucose, 14NH4). The data are consistent with the hypothesis that both the chromosome and the F plasmid are replicated in a ce... | ['Cell Cycle', 'DNA Replication', 'DNA, Bacterial', 'Escherichia coli', 'F Factor'] | 1,551,835 | [['G04.144'], ['G02.111.225', 'G05.226'], ['D13.444.308.212'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['G05.360.600.300']] | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Enhanced mobility of neural cells with a transparent electric field stimulator. | Mobility is one of the important characteristics of living cells. It also plays a significant role in therapeutic cell transplantation with target location specificity. To enhance cell mobility, a neural cell stimulator was assembled with graphenes, which are two-dimensional nanocarbon materials that form a transparent... | ['Cell Line', 'Cell Movement', 'Electric Stimulation', 'Equipment Design', 'Equipment Failure Analysis', 'Humans', 'Microelectrodes', 'Nanotechnology', 'Neurons', 'Radiation Dosage', 'Refractometry'] | 22,966,549 | [['A11.251.210'], ['G04.198', 'G07.568.500.180'], ['E05.723.402'], ['E05.320'], ['E05.325.192'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E07.305.250.500'], ['H01.603', 'J01.897.520.600'], ['A08.675', 'A11.671'], ['E05.799.513', 'G01.750.740', 'N06.850.810.250'], ['E05.196.808', 'H01.671.617.755']] | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 |
Neoadjuvant chemotherapy and radiotherapy for the treatment of advanced hypopharyngeal carcinoma. | PURPOSE: To evaluate the efficacy of the neoadjuvant chemotherapy and radiation therapy in treatment of patients with advanced hypopharyngeal cancer, which is notorious for its poor prognosis and severe surgical morbidity with functional deficits.MATERIALS AND METHODS: Medical records of 62 patients with squamous cell ... | ['Adult', 'Aged', 'Aged, 80 and over', 'Carcinoma, Squamous Cell', 'Chemotherapy, Adjuvant', 'Combined Modality Therapy', 'Disease-Free Survival', 'Female', 'Humans', 'Hypopharyngeal Neoplasms', 'Male', 'Middle Aged', 'Remission Induction', 'Retrospective Studies', 'Survival Rate', 'Treatment Outcome'] | 9,470,950 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['E02.186.170', 'E02.319.170'], ['E02.186'], ['E01.789.800.190', 'E05.318.740.998.300', 'N04.761.559.590.800.190', 'N05.715.360.575.575.800.190', 'N05.715.360.750.795.300', 'N06.850.520.830.998.300'], ['B01.0... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Myocardial uptake of thallous ion in animals. | The details of the metabolism of thallium are still unknown. The former hypothesis that 201thallium as used for myocardial imaging follows a potassium-like metabolism was called in question after animal experiments with rats and guinea-pigs. A critical review basing on these results and the results of patients' assessm... | ['Animals', 'Canrenoic Acid', 'Guinea Pigs', 'Myocardium', 'Ouabain', 'Radioisotopes', 'Rats', 'Thallium'] | 6,213,495 | [['B01.050'], ['D04.210.500.745.432.100'], ['B01.050.150.900.649.313.992.550'], ['A02.633.580', 'A07.541.704', 'A10.690.552.750'], ['D04.210.500.155.580.130.750.600', 'D09.408.180.810.600'], ['D01.496.749'], ['B01.050.150.900.649.313.992.635.505.700'], ['D01.268.556.847', 'D01.552.544.847']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
What constitutes effective coping and efficient physiologic regulation following psychosocial stress depends on involuntary stress responses. | This study utilized a random-assignment experimental design to examine the interactive contributions of youth-reported trait involuntary stress responses (ISRs) and effortful coping on physiologic reactivity and recovery patterns in preadolescent boys and girls. Fourth- and fifth-grade child-parent dyads (N=126) partic... | ['Adaptation, Psychological', 'Child', 'Female', 'Humans', 'Hydrocortisone', 'Interpersonal Relations', 'Male', 'Saliva', 'Salivary alpha-Amylases', 'Stress, Psychological'] | 27,448,527 | [['F01.058'], ['M01.060.406'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D04.210.500.745.745.654.600', 'D06.472.040.585.353.476', 'D06.472.040.585.478.392'], ['F01.829.401'], ['A12.200.666'], ['D08.811.277.450.066.050.500', 'D12.644.848.875', 'D12.776.850.887'], ['F01.145.126.990', 'F02.830.900']] | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The effect of ultraviolet B irradiation and urocanic acid isomers on dendritic cell migration. | Irradiation with ultraviolet-B light (UV-B) suppresses some cell-mediated immune responses to a variety of antigens, including contact sensitizers. Following UV irradiation there is modulation of Langerhans' cells' markers and keratinocytes are induced to synthesize and secrete tumour necrosis factor-alpha (TNF-alpha).... | ['Animals', 'Cell Movement', 'Dendritic Cells', 'Female', 'Fluorescein-5-isothiocyanate', 'Histocompatibility Antigens Class II', 'Kinetics', 'Lymph Nodes', 'Mice', 'Mice, Inbred C3H', 'Ultraviolet Rays', 'Urocanic Acid'] | 1,478,685 | [['B01.050'], ['G04.198', 'G07.568.500.180'], ['A11.066.270', 'A11.436.270', 'A15.382.066.270', 'A15.382.670.260'], ['D02.455.426.779.347.400', 'D02.500.375.250', 'D02.886.250.250', 'D03.633.300.953.275.400', 'D04.711.347.400'], ['D12.776.395.550.509', 'D12.776.543.550.440', 'D23.050.301.500.400', 'D23.050.705.552.410'... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Synthesis of octapeptin C4 and biological profiling against NDM-1 and polymyxin-resistant bacteria. | The first synthesis of octapeptin C4 was achieved using a combination of solid phase synthesis and off-resin cyclisation. Octapeptin C4 displayed antibiotic activity against multi-drug resistant, NDM-1 and polymyxin-resistant Gram-negative bacteria, with moderate activity against Staphylococcus aureus. The linear analo... | ['Anti-Bacterial Agents', 'Cyclization', 'Drug Resistance, Bacterial', 'Gram-Negative Bacteria', 'Lipopeptides', 'Peptides, Cyclic', 'Polymyxin B', 'Solid-Phase Synthesis Techniques', 'Staphylococcus aureus'] | 28,454,673 | [['D27.505.954.122.085'], ['G02.111.180', 'G02.607.133', 'G03.208'], ['G06.099.225', 'G06.225.347', 'G07.690.773.984.269.347'], ['B03.440'], ['D10.477', 'D12.644.365'], ['D04.345.566', 'D12.644.641'], ['D04.345.566.780.750', 'D10.477.750.750', 'D12.644.050.600.750', 'D12.644.641.780.750', 'D12.776.543.695.054.600.750']... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Lyme borreliosis in children. A controlled clinical study based on ELISA values. | A total of 27 children with clinical symptoms indicative of Lyme borreliosis are described, 21 of which were seropositive. CNS symptoms were found in 17 of the seropositive children (81%). Of these 21, 7 were CSF negative. Another 3 (with Bell's palsy and/or aseptic meningitis) were initially CSF negative but developed... | ['Adolescent', 'Animals', 'Arthritis, Infectious', 'Borrelia Infections', 'Central Nervous System Diseases', 'Child', 'Child, Preschool', 'Enzyme-Linked Immunosorbent Assay', 'Female', 'Humans', 'Immunoglobulin G', 'Insect Vectors', 'Male', 'Ticks'] | 2,744,014 | [['M01.060.057'], ['B01.050'], ['C01.100', 'C05.550.114.099'], ['C01.150.252.400.794.352'], ['C10.228'], ['M01.060.406'], ['M01.060.406.448'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.1... | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Understanding physicians' professional knowledge and practice in research on skilled migration. | Research on the integration of migrant professionals into high-skilled labor markets either focuses on differences between nation states which may be exacerbated by national closure or it celebrates the global versatility of professional knowledge, especially in the natural and health sciences. Building on a pragmatist... | ['Clinical Competence', 'Cultural Competency', 'Emigration and Immigration', 'Humans', 'Physicians', 'Problem Solving', 'Research'] | 26,158,400 | [['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['I01.880.853.100.364'], ['I01.240.600.525.500', 'N01.224.625.525.500', 'N06.850.505.400.700.525.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.526.485.810', 'N02.360.810'], ['F02.463.425.725', 'F02.463.785.810'], ['H01.770.644']] | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 |
[The diagnostic value of the maximum value of Young's modulus of shear-wave elastography and ACR TI-RADS for thyroid nodules]. | Objective:The aim of this study is to assess the application value of maximum Young's modulus of shear wave elastography in combination with Thyroid Imaging Reporting and Data System set by the American College of Radiology in the diagnosis of benign and malignant thyroid nodules. Method:A retrospective analysis of 113... | ['Elastic Modulus', 'Elasticity Imaging Techniques', 'Humans', 'Retrospective Studies', 'Sensitivity and Specificity', 'Thyroid Nodule', 'Ultrasonography'] | 31,446,736 | [['G01.374.590.605'], ['E01.370.350.850.270'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.520.450.500.500.500', 'N06.850.520.450.500.750.825'], ['E05.318.370.800', 'E05.318.740.872', 'G17.... | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Unique case of tubulocystic carcinoma of the kidney with sarcomatoid features: a new entity. | Tubulocystic carcinoma of the kidney is a recently reported rare entity, with very few reports in the literature. It has always been described as a low-grade malignancy with favorable prognosis. We report the case of 33-year-old man who presented with back pain. Investigations revealed multiple bony metastases and a la... | ['Adult', 'Carcinoma, Renal Cell', 'Humans', 'Kidney Neoplasms', 'Male'] | 21,439,613 | [['M01.060.116'], ['C04.557.470.200.025.390', 'C04.588.945.947.535.160', 'C12.758.820.750.160', 'C12.777.419.473.160', 'C13.351.937.820.535.160', 'C13.351.968.419.473.160'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.945.947.535', 'C12.758.820.750', 'C12.777.419.473', 'C13.351.937.820.535', 'C13.351.968... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Estimation and asymptotic theory for transition probabilities in Markov renewal multi-state models. | In this paper we discuss estimation of transition probabilities for semi-Markov multi-state models. Non-parametric and semi-parametric estimators of the transition probabilities for a large class of models (forward going models) are proposed. Large sample theory is derived using the functional delta method and the use ... | ['Adult', 'Biostatistics', 'Humans', 'Markov Chains', 'Middle Aged', 'Models, Statistical', 'Statistics, Nonparametric', 'Survival Analysis'] | 22,944,722 | [['M01.060.116'], ['E05.318.740.237'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.600.500', 'E05.318.740.996.500', 'G17.830.500', 'N05.715.360.750.625.500', 'N05.715.360.750.770.500', 'N06.850.520.830.600.500', 'N06.850.520.830.996.500'], ['M01.060.116.630'], ['E05.318.740.500', 'E05.599.835', 'N05.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Assaying Wnt5A-mediated invasion in melanoma cells. | Wnt5A has been implicated in melanoma metastasis, and the progression of other cancers including pancreatic, gastric, prostate, and lung cancers. Assays to test motility and invasion include both in vivo assays and in vitro assays. The in vivo assays include the use of tail vein or footpad injections of metastatic cell... | ['Cell Culture Techniques', 'Cell Line, Tumor', 'Cell Movement', 'Collagen', 'Drug Combinations', 'Humans', 'Laminin', 'Melanoma', 'Neoplasm Invasiveness', 'Protein Kinase C', 'Proteoglycans', 'Proto-Oncogene Proteins', 'Wnt Proteins', 'Wnt-5a Protein'] | 19,099,260 | [['E01.370.225.500.223', 'E05.200.500.265', 'E05.242.223', 'E05.481.500.249'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.198', 'G07.568.500.180'], ['D05.750.078.280', 'D12.776.860.300.250'], ['D26.310'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.395.550.530', 'D12.776.543.550.500', 'D12.776.860.300... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Language processing, slowing, and speed/accuracy trade-off in the elderly. | Previous studies have suggested that longer response times in older adults could be partly due to increased caution in responding, with a propensity to emphasize accuracy to the detriment of speed. A study was carried out in 30 young and 30 older adults in order to determine whether shifting the response criterion rela... | ['Adult', 'Aged', 'Aging', 'Cognition', 'Cognition Disorders', 'Female', 'Humans', 'Language', 'Language Disorders', 'Language Tests', 'Male', 'Middle Aged', 'Reaction Time', 'Speech'] | 11,330,210 | [['M01.060.116'], ['M01.060.116.100'], ['G07.345.124'], ['F02.463.188'], ['F03.615.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.209.399', 'L01.559'], ['C10.597.606.150.500', 'C23.888.592.604.150.500'], ['F04.711.513.240'], ['M01.060.116.630'], ['E05.796.817', 'F02.830.650', 'F04.669.817', 'G11.561.... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Information Science [L]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Effects of Cardiovascular Health Factors and Personal Listening Behaviors on Hearing Sensitivity in College-Aged students. | OBJECTIVES: This study examined the association between pure tone hearing sensitivity and music listening behaviors among traditional college-aged students and sought to determine factors that mediate hearing sensitivity, including health and fitness levels, gender, and personal listening device (PLD) use.METHODS: A co... | ['Adolescent', 'Adult', 'Auditory Perception', 'Auditory Threshold', 'Cardiovascular Diseases', 'Female', 'Health Status', 'Hearing Loss, Noise-Induced', 'Hearing Tests', 'Humans', 'Male', 'Students', 'Surveys and Questionnaires', 'Young Adult'] | 32,146,824 | [['M01.060.057'], ['M01.060.116'], ['F02.463.593.071', 'G07.888.125'], ['F02.463.593.071.173', 'F02.463.593.710.190', 'G07.888.125.173'], ['C14'], ['I01.240.425', 'N01.224.425', 'N06.850.505.400.425'], ['C09.218.458.341.887.460', 'C10.597.751.418.341.887.460', 'C23.888.592.763.393.341.887.460'], ['E01.370.382.375'], ['... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Assessment of mast cells degranulation in rainbow trout (Oncorhynchus mykiss Walbaum) by means of gray level and texture analysis (Gray Level Correlation Matrices). | Degranulation of intestinal mast cells in rainbow trout (Oncorhynchus mykiss Walbaum) was studied by means of image analysis technique. Two strips from the same intestinal segment from ten clinically healthy trout were sampled. One was immediately mounted in an organ bath, treated with compound 48/80 and then processed... | ['Animals', 'Cell Degranulation', 'Color', 'Cytoplasm', 'Mast Cells', 'Oncorhynchus mykiss', 'p-Methoxy-N-methylphenethylamine'] | 22,153,021 | [['B01.050'], ['G04.468.160'], ['G01.590.540.199'], ['A11.284.430.214'], ['A11.329.427', 'A15.382.652'], ['B01.050.150.900.493.817.750.825.580.600'], ['D02.092.471.683.670']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Transplacental stimulation of fetal lung maturation: effect of triiodothyronine in the female and male rabbit fetus. | We have recently demonstrated that intramuscular administration of triiodothyronine (T3) or thyroxine (T4) to the rabbit doe results in its transfer across the placenta. In this study we investigated the effect of maternally administered T3 upon the functional and morphologic fetal lung maturation. T3 (175 micrograms/k... | ['Animals', 'Female', 'Fetal Organ Maturity', 'Fetus', 'Lung', 'Male', 'Maternal-Fetal Exchange', 'Pregnancy', 'Rabbits', 'Triiodothyronine'] | 3,651,523 | [['B01.050'], ['G07.345.500.325.235.750', 'G07.345.500.325.377.249', 'G08.686.784.170.157.750'], ['A16.378'], ['A04.411'], ['G08.686.784.769.455'], ['G08.686.784.769'], ['B01.050.150.900.649.313.968.700'], ['D06.472.931.740.385', 'D12.125.072.050.767.741.894']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Interaction of diltiazem with single L-type calcium channels in guinea-pig ventricular myocytes. | The effects of diltiazem on cardiac L-type calcium channels were studied at the single channel level, using Ba2+ ions as the charge carrier. Patch clamp experiments were performed on enzymatically isolated guinea-pig ventricular myocytes. It was shown in cell-attached configuration on multichannel patches that diltiaze... | ['Animals', 'Calcium Channels', 'Diltiazem', 'Guinea Pigs', 'Heart', 'In Vitro Techniques', 'Kinetics', 'Membrane Potentials', 'Myocardium'] | 1,338,047 | [['B01.050'], ['D12.776.157.530.400.150', 'D12.776.543.550.450.150', 'D12.776.543.585.400.150'], ['D03.633.100.079.150'], ['B01.050.150.900.649.313.992.550'], ['A07.541'], ['E05.481'], ['G01.374.661', 'G02.111.490'], ['G01.154.535', 'G04.580', 'G07.265.675', 'G11.561.570'], ['A02.633.580', 'A07.541.704', 'A10.690.552.7... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
An immunoregulatory factor associated with spleen cells from tumor-bearing animals. III. Characterization of the factor's target cells. | An immunoregulatory factor associated with spleen cells from tumor-bearing mice was found to potentiate the generation of antibody-producing cells (APC). In an attempt to characterize the target cell of this enhancing factor (EF), its activity in mice devoid of mature T lymphocytes was tested. Levels of anti-SRBC APC w... | ['Animals', 'Antibody Formation', 'Antibody-Producing Cells', 'B-Lymphocytes', 'Erythrocytes', 'Haptens', 'Hemolytic Plaque Technique', 'Lung Neoplasms', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Mice, Nude', 'Neoplasms, Experimental', 'Spleen', 'T-Lymphocytes', 'Thymectomy'] | 374,284 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Azacitidine in lower-risk myelodysplastic syndromes. | Azacitidine is the first agent to significantly prolong overall survival (OS) compared with conventional care regimens in patients with higher-risk myelodysplastic syndromes (MDS). Here, we review currently available data on azacitidine treatment in lower-risk MDS. In a phase III study, a subset of patients with lower-... | ['Antineoplastic Agents', 'Azacitidine', 'Humans', 'Myelodysplastic Syndromes'] | 20,004,794 | [['D27.505.954.248'], ['D02.145.150', 'D03.383.742.680.245.217', 'D13.570.685.245.217', 'D13.570.800.286.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C15.378.190.625']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Attitudes to rapid HIV testing among Spanish General Practitioners. | OBJECTIVES: The objectives of this study were to investigate the acceptability of rapid HIV testing among general practitioners in Spain and to identify perceived barriers and needs in order to implement rapid testing in primary care settings.METHODS: An anonymous questionnaire was distributed online to all members of ... | ['Adult', 'Attitude of Health Personnel', 'Counseling', 'Early Diagnosis', 'Female', 'General Practice', 'General Practitioners', 'HIV Infections', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Knowledge', 'Male', 'Primary Health Care', 'Spain', 'Surveys and Questionnaires'] | 24,033,906 | [['M01.060.116'], ['F01.100.050', 'N05.300.100'], ['F02.784.176', 'F04.408.413', 'N02.421.143.303', 'N02.421.461.363'], ['E01.390'], ['H02.403.340'], ['M01.526.485.810.485', 'N02.360.810.485'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Diseases [C]', 'Organisms [B]', 'Humanities [K]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
A prospective evaluation of the Infection Probability Score (IPS) in the intensive care unit. | OBJECTIVES: Identification of infection remains a major challenge, particularly in acutely ill patients. The Infection Probability Score (IPS) was developed to help rule out infection in acutely ill patients. In the present study, we determined the IPS in acutely ill, intensive care unit (ICU) patients to assess its us... | ['Adult', 'Aged', 'Aged, 80 and over', 'Anti-Bacterial Agents', 'Body Temperature', 'C-Reactive Protein', 'Critical Illness', 'Cross Infection', 'Female', 'Heart Rate', 'Humans', 'Intensive Care Units', 'Leukocyte Count', 'Male', 'Middle Aged', 'Multiple Organ Failure', 'Severity of Illness Index'] | 18,410,969 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.954.122.085'], ['E01.370.600.875.374', 'G07.110'], ['D12.776.034.145', 'D12.776.124.050.120', 'D12.776.124.486.157'], ['C23.550.291.625'], ['C01.248', 'C23.550.291.875.500'], ['E01.370.600.875.500', 'G09.330.380.500'], ['B01.050.150.900.649.313.9... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Efficacy and safety of low dose desmopressin orally disintegrating tablet in women with nocturia: results of a multicenter, randomized, double-blind, placebo controlled, parallel group study. | PURPOSE: Previous studies suggest a lower dose of desmopressin orally disintegrating tablet may be effective in females compared to males with nocturia. We confirm the efficacy and safety of 25 ìg desmopressin orally disintegrating tablet compared to placebo in female patients.MATERIALS AND METHODS: In this 3-month, ra... | ['Administration, Oral', 'Adult', 'Aged', 'Aged, 80 and over', 'Antidiuretic Agents', 'Deamino Arginine Vasopressin', 'Dose-Response Relationship, Drug', 'Double-Blind Method', 'Drug Administration Schedule', 'Female', 'Follow-Up Studies', 'Humans', 'Middle Aged', 'Multivariate Analysis', 'Nocturia', 'Patient Safety', ... | 23,454,404 | [['E02.319.267.100'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.696.560.249'], ['D06.472.699.631.692.781.100.250', 'D12.644.400.900.100.250', 'D12.644.456.925.100.250', 'D12.644.548.691.692.781.100.250', 'D12.776.631.650.937.100.250'], ['G07.690.773.875', 'G07.690.936.500'], ['E05.318.370... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Accidental poisoning after ingestion of "aphrodisiac" berries: diagnosis by analytical toxicology. | BACKGROUND: A large number of plants, seeds, and berries have been used for medicinal, psychotropic, or aphrodisiac purposes for a thousand years. Mandragora officinarum belongs to the family of Solanaceae and is traditionally known as an aphrodisiac and is closely associated with witchcraft.OBJECTIVES: In this study w... | ['Adult', 'Fruit', 'Humans', 'Male', 'Mandragora', 'Plant Poisoning', 'Plants, Medicinal', 'Plants, Toxic'] | 21,571,482 | [['M01.060.116'], ['A18.024.500', 'G07.203.300.562', 'J02.500.562'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.650.940.800.575.912.250.908.500.347'], ['C25.723.756'], ['B01.650.560'], ['B01.650.660']] | ['Named Groups [M]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 |
Cutaneous botryomycosis. | We report four cases of cutaneous botryomycosis. The predisposing factors included alcoholism, diabetes, and trauma. Clinically, the patients had nodules, suppurative plaques, or ulcers. In two cases, Staphylococcus aureus was cultured. In one case Neisseria species was cultured and in another a coagulase-negative Stap... | ['Adolescent', 'Bacterial Infections', 'Chronic Disease', 'Corynebacterium', 'Corynebacterium Infections', 'Female', 'Humans', 'Male', 'Meningococcal Infections', 'Middle Aged', 'Neisseria', 'Skin Diseases, Infectious', 'Staphylococcal Skin Infections', 'Staphylococcus aureus'] | 2,061,434 | [['M01.060.057'], ['C01.150.252'], ['C23.550.291.500'], ['B03.510.024.250', 'B03.510.460.400.400.200'], ['C01.150.252.410.040.246'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C01.150.252.400.625.549'], ['M01.060.116.630'], ['B03.440.400.425.550.550', 'B03.660.075.525.520'], ['C01.800', 'C17.800.838'], ['C01.15... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The complete maps of BglII, SalI and XhoI restriction sites on T4 dC-DNA. | T4 dC-DNA was digested with the restriction endonucleases BglII, SalI and XhoI. Overlaps in the three sets of fragments allowed the mapping of all restriction sites relative to each other along the T4 genome. | ['Chromosome Mapping', 'DNA Restriction Enzymes', 'DNA, Viral', 'Electrophoresis, Agar Gel', 'Molecular Weight', 'T-Phages'] | 293,460 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Admission variables as predictors of completion in an adolescent residential drug treatment program. | PROBLEM: Understanding of the pretreatment characteristics of drug-dependent adolescents to better match clients to treatment models that serve their needs for successful recovery.METHODS: A random sample of (N = 91) clients records were selected for this outcomes pilot. Chi-square analysis examined differences between... | ['Adolescent', 'Alcoholism', 'Female', 'Humans', 'Male', 'Nursing Assessment', 'Outcome Assessment, Health Care', 'Patient Admission', 'Patient Dropouts', 'Patient Readmission', 'Pilot Projects', 'Prognosis', 'Residential Treatment', 'Risk Assessment', 'Risk Factors', 'Substance-Related Disorders'] | 16,236,098 | [['M01.060.057'], ['C25.775.100.250', 'F03.900.100.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N04.590.233.508.480'], ['H01.770.644.145.431', 'N04.761.559.590', 'N05.715.360.575.575'], ['E02.760.400.600', 'N02.421.585.400.600'], ['F01.100.150.750.500.610', 'F01.145.488.887.500.610', 'N05.300.150.800.500.6... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Short communication: Metritis affects milk production and cull rate of Holstein multiparous and primiparous dairy cows differently. | Metritis, a common transition disease in dairy cows, reduces milk production during the duration of the disease. To our knowledge, no work has investigated the short-term effects of metritis on feed intake and the long-term consequences on milk yield and risk of culling. The objectives were to determine the effect of m... | ['Animals', 'Cattle', 'Cattle Diseases', 'Eating', 'Endometritis', 'Female', 'Lactation', 'Milk', 'Parity', 'Pregnancy', 'Puerperal Infection', 'Reproduction', 'Risk Factors'] | 21,524,531 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['C22.196'], ['G07.203.650.283', 'G10.261.330'], ['C13.351.500.056.750.249', 'C13.351.500.852.299'], ['G08.686.523', 'G08.686.702.500'], ['A12.200.455', 'A12.790', 'G07.203.100.700', 'G07.203.300.350.525', 'J02.200.700', 'J02.500.350.525'], ['G08.686.677', 'G08.686... | ['Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Improved Diagnostic Accuracy of SPECT Through Statistical Analysis and the Detection of Hot Spots at the Primary Sensorimotor Area for the Diagnosis of Alzheimer Disease in a Community-Based Study: "The Osaki-Tajiri Project". | PURPOSE: SPECT is an important diagnostic tool for dementia. Recently, statistical analysis of SPECT has been commonly used for dementia research. In this study, we evaluated the accuracy of visual SPECT evaluation and/or statistical analysis for the diagnosis (Dx) of Alzheimer disease (AD) and other forms of dementia ... | ['Aged', 'Aged, 80 and over', 'Alzheimer Disease', 'Female', 'Humans', 'Image Processing, Computer-Assisted', 'Male', 'Residence Characteristics', 'Sensitivity and Specificity', 'Sensorimotor Cortex', 'Tomography, Emission-Computed, Single-Photon'] | 26,359,573 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['N01.224.791', 'N06.850.505.400.800'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700', 'N05.715.360.750.725', 'N06.850... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Information Science [L]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Breast movement during normal and deep breathing, respiratory training and set up errors: implications for external beam partial breast irradiation. | This study was designed to evaluate interfraction and intrafraction breast movement and to study the effect of respiratory training on respiratory indices. Five patients were immobilized in supine position in a vacuum bag and three-dimensional set up errors, respiratory movement of the breast during normal and deep bre... | ['Brachytherapy', 'Breast', 'Breast Neoplasms', 'Female', 'Humans', 'Movement', 'Patient Education as Topic', 'Respiration'] | 16,940,376 | [['E02.815.150'], ['A01.236'], ['C04.588.180', 'C17.800.090.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G07.568', 'G11.427.410'], ['I02.233.332.500', 'N02.421.726.407.680'], ['G09.772.705']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Chronic administration of AFQ056/Mavoglurant restores social behaviour in Fmr1 knockout mice. | Fragile X syndrome is caused by lack of FMR1 protein (FMRP) leading to severe symptoms, including intellectual disability, hyperactivity and autistic-like behaviour. FMRP is an RNA binding protein involved in the regulation of translation of specific target mRNAs upon stimulation of metabotropic glutamate receptor 5 (m... | ['Animals', 'Disease Models, Animal', 'Excitatory Amino Acid Antagonists', 'Fragile X Mental Retardation Protein', 'Fragile X Syndrome', 'Indoles', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Mice, Knockout', 'Receptor, Metabotropic Glutamate 5', 'Receptors, Metabotropic Glutamate', 'Social Behavior', 'Time Factors'] | 23,142,366 | [['B01.050'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['D27.505.519.625.190.300', 'D27.505.696.577.190.300'], ['D12.776.157.725.061', 'D12.776.631.299', 'D12.776.664.962.124'], ['C10.597.606.360.455.500', 'C16.131.260.830.300', 'C16.320.180.830.300', 'C16.320.322.500.500', 'C16.320.400.525.500'], ['D03.633.100.4... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Diffuse retinal epitheliopathy: study of 30 eyes]. | Retrospective study of 17 patients (30 eyes) with diffuse retinal epitheliopathy followed for at least 5 years. The study is based on clinical data, ophthalmoscopic findings and fluorescein angiograms. The patients (16 men and 1 woman) are all caucasian with a mean age of 43 years. The disease is bilateral in 13 patien... | ['Adrenal Cortex Hormones', 'Adult', 'Atrophy', 'Diabetes Complications', 'Female', 'Fluorescein Angiography', 'Follow-Up Studies', 'Humans', 'Hypertension', 'Kidney Transplantation', 'Male', 'Retinal Detachment', 'Retrospective Studies', 'Stress, Psychological'] | 12,879,725 | [['D06.472.040'], ['M01.060.116'], ['C23.300.070'], ['C19.246.099'], ['E01.370.370.050.350', 'E01.370.380.250'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['E02.870.500', 'E04.936.450.485', 'E04.950.774.40... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Prediction of difficult laparoscopic cholecystectomy for acute cholecystitis. | BACKGROUND: No report has described the predictive factor of surgical difficulty for laparoscopic cholecystectomy (LC) by preoperative computed tomography (CT) findings. This study aimed to investigate whether dynamic CT findings can predict the difficulty of LC for acute cholecystitis.MATERIALS AND METHODS: Fifty-seve... | ['Adult', 'Aged', 'Cholecystectomy, Laparoscopic', 'Cholecystitis, Acute', 'Decision Support Techniques', 'Female', 'Humans', 'Male', 'Middle Aged', 'Preoperative Care', 'Retrospective Studies', 'Tomography, X-Ray Computed'] | 28,807,199 | [['M01.060.116'], ['M01.060.116.100'], ['E04.210.120.172.140', 'E04.502.250.520.160'], ['C06.130.564.263.500'], ['E05.245', 'L01.313.500.750.190'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E02.760.795', 'E04.604.750', 'N02.421.585.795'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.75... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Information Science [L]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
A rod domain sequence in segment 1B triggers dimerisation of the two small Branchiostoma IF proteins B2 and A3. | Previously, we cloned two Branchiostoma IF proteins A3 and B2 and demonstrated that both can form heteropolymeric IF based on a coiled coil dimer consisting of one B2 and one A3 polypeptide. In this study we continued in the characterisation of the B2/A3 heterodimer by searching for the sequences that play an important... | ['Amino Acid Motifs', 'Amino Acid Sequence', 'Animals', 'Chordata, Nonvertebrate', 'Intermediate Filament Proteins', 'Molecular Sequence Data', 'Protein Multimerization', 'Protein Structure, Tertiary'] | 22,878,087 | [['G02.111.570.820.709.275.500', 'G02.111.570.820.709.600.500'], ['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['B01.050.150.200', 'B01.050.500.272'], ['D05.750.078.593', 'D12.776.220.475'], ['L01.453.245.667'], ['G02.111.694'], ['G02.111.570.820.709.610']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Thrombin and thrombin receptor agonist peptide induce tyrosine phosphorylation and tyrosine kinases in the platelet cytoskeleton. Translocation of pp60c-src and integrin alpha IIb beta 3 (glycoprotein IIb/IIIa) is not required for aggregation, but is dependent on formation of large aggregate structures. | The maximal aggregation of platelets induced by alpha-thrombin or by the receptor agonist peptide thrombin-(42-47)-peptide (TRP42/47) rapidly increased the pp60c-src associated with the cytoskeleton fraction. There was good correlation between the tyrosine kinase activity and the mass of pp60c-src. Tyrosine kinase acti... | ['Amino Acid Sequence', 'Biological Transport', 'Blood Platelets', 'Cytoskeleton', 'Enzyme Induction', 'Humans', 'Integrins', 'Molecular Sequence Data', 'Peptide Fragments', 'Phosphorylation', 'Platelet Aggregation', 'Platelet Membrane Glycoproteins', 'Protein-Tyrosine Kinases', 'Proto-Oncogene Proteins pp60(c-src)', '... | 7,689,831 | [['G02.111.570.060', 'L01.453.245.667.060'], ['G03.143'], ['A11.118.188', 'A15.145.229.188'], ['A11.284.430.214.190.750'], ['G05.308.320.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.543.750.705.408'], ['L01.453.245.667'], ['D12.644.541'], ['G02.111.665', 'G02.607.780', 'G03.796'], ['G09.188.370.687... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Inhibition of experimental metastasis by targeting the HUIV26 cryptic epitope in collagen. | Metastasis from the primary tumor to distant sites involves an array of molecules that function in an integrated manner. Proteolytic remodeling and subsequent tumor cell interactions with the extracellular matrix regulate tumor invasion. In previous studies, we have identified a cryptic epitope (HUIV26) that is specifi... | ['Animals', 'Antibodies, Monoclonal', 'Cell Adhesion', 'Cell Line, Tumor', 'Cell Movement', 'Chick Embryo', 'Collagen', 'Collagen Type IV', 'Disease Models, Animal', 'Dose-Response Relationship, Drug', 'Epitopes', 'Lung', 'Lung Neoplasms', 'Mice', 'Neoplasm Metastasis'] | 16,651,624 | [['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['G04.022'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.198', 'G07.568.500.180'], ['A13.350.150', 'A16.331.200'], ['D05.750.078.280', 'D12.776.860.300.250'], ['D12.776.860.300.250.400.100'], ['C22.232', 'E05.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
CD40 induces antigen transporter and immunoproteasome gene expression in carcinomas via the coordinated action of NF-kappaB and of NF-kappaB-mediated de novo synthesis of IRF-1. | Cancer cells may evade immune surveillance as a result of defective antigen processing and presentation. In this study, we demonstrate that CD40 ligation overcomes this defect through the coordinated action of the transcription factors NF-kappaB and interferon regulatory factor 1 (IRF-1). We show that unlike interferon... | ['ATP-Binding Cassette Transporters', 'Antigen Presentation', 'CD40 Antigens', 'Cell Line, Tumor', 'Cysteine Endopeptidases', 'Enzyme Induction', 'Gene Expression Regulation, Neoplastic', 'Humans', 'Interferon Regulatory Factor-1', 'Mitogen-Activated Protein Kinases', 'NF-kappa B', 'Neoplasms', 'Promoter Regions, Genet... | 18,694,960 | [['D12.776.157.530.100', 'D12.776.395.550.020', 'D12.776.543.550.192', 'D12.776.543.585.100'], ['G12.119', 'G12.450.050.400.070'], ['D12.776.465.750', 'D12.776.543.750.705.852.760.097', 'D23.050.301.264.051.140', 'D23.101.100.150.140'], ['A11.251.210.190', 'A11.251.860.180'], ['D08.811.277.656.262.500', 'D08.811.277.65... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Influence of an intraoperative perilymph gusher on cochlear implant performance in children with labyrinthine malformations. | OBJECTIVES: To assess the effect of an intraoperative perilymph fluid gusher during cochlear implantation on speech perception abilities in pediatric patients with labyrinthine anomalies.SETTING: Tertiary care academic referral center.METHODS: Seventy subjects with labyrinthine malformations who received a cochlear imp... | ['Adolescent', 'Audiometry', 'Child', 'Child, Preschool', 'Cochlea', 'Cochlear Implantation', 'Cochlear Implants', 'Connexins', 'Databases, Factual', 'Ear, Inner', 'Female', 'Follow-Up Studies', 'Hearing Tests', 'Humans', 'Infant', 'Intraoperative Complications', 'Language Tests', 'Male', 'Perilymph', 'Speech Perceptio... | 22,996,156 | [['M01.060.057'], ['E01.370.382.375.060'], ['M01.060.406'], ['M01.060.406.448'], ['A09.246.300.246'], ['E04.580.450.220', 'E04.650.220'], ['E07.305.250.319.381.500.500', 'E07.695.150', 'E07.695.202.381.500.500', 'E07.814.458.150'], ['D12.776.543.585.250'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['A09.246.3... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Information Science [L]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Transactivation via RAR/RXR-Sp1 interaction: characterization of binding between Sp1 and GC box motif. | Modulation of Sp1 activity by nuclear receptors is a novel mechanism by which fat-soluble hormones regulate gene expression. We previously established that upon autoinduction of RARs by RA, RARs/RXRs physically interact with Sp1, potentiate Sp1 binding to the GC box motifs, and thus enhance transactivation of the uroki... | ['Animals', 'Base Sequence', 'Blotting, Northern', 'Blotting, Western', 'Cattle', 'Endothelium, Vascular', 'Gene Expression Regulation', 'Humans', 'Mice', 'Plicamycin', 'Promoter Regions, Genetic', 'RNA, Messenger', 'Receptors, Retinoic Acid', 'Receptors, Transforming Growth Factor beta', 'Response Elements', 'Retinoid... | 11,579,201 | [['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.196.401.095', 'E05.301.300.074', 'E05.601.100'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['B01.050.150.900.649.313.500.380.271'], ['A07.015.700.500', 'A10.272.491.355'], ['G05.308'... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Thermogravimetry study of xylanase- and laccase/mediator-treated eucalyptus pulp fibres. | Thermogravimetric analyses (TGA) was applied to study the effects of enzymatic bleaching of eucalyptus pulp with xylanase and a laccase-mediator system. The thermal degradation profile of the pulps was sensitive to the enzymatic treatments. Xylanase treatment produced an ordered and clean microfibril, whereas laccase o... | ['Chromatography, High Pressure Liquid', 'Endo-1,4-beta Xylanases', 'Eucalyptus', 'Laccase', 'Paper', 'Plant Stems', 'Spectroscopy, Fourier Transform Infrared', 'Thermogravimetry', 'X-Ray Diffraction'] | 21,840,212 | [['E05.196.181.400.300'], ['D08.811.277.450.950.249'], ['B01.650.940.800.575.912.250.773.366'], ['D08.811.682.494'], ['J01.637.650'], ['A18.024.937'], ['E05.196.712.726.676.700', 'E05.196.867.826.676.700'], ['E05.196.904'], ['E05.196.309.742', 'E05.196.822.950', 'G01.867.950', 'G02.965']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Phosphorylation of hepatitis B virus precore and core proteins. | Hepatitis B virus precore and core proteins are related. The precore protein contains the entire sequence of the core protein plus an amino-terminal extension of 29 amino acids. The amino-terminal extension of the precore protein contains a signal sequence for the secretion of the precore protein. This signal sequence ... | ['Animals', 'Carcinoma, Hepatocellular', 'Cell Fractionation', 'Cell Line', 'Cloning, Molecular', 'Endoplasmic Reticulum', 'Hepatitis B virus', 'Humans', 'Microsomes', 'Phosphorylation', 'Protein Kinases', 'Protein Precursors', 'Protein Sorting Signals', 'Transfection', 'Trypsin', 'Tumor Cells, Cultured', 'Viral Core P... | 1,850,014 | [['B01.050'], ['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['E05.242.251'], ['A11.251.210'], ['E05.393.220'], ['A11.284.430.214.190.875.248'], ['B04.280.375.650.425', 'B04.450.390.650.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.284.835.540'], ['G02.111.665'... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Financial impact of elimination of routine chest radiographs in a pediatric intensive care unit. | OBJECTIVE: To determine the change in chest radiograph use if each chest radiograph requires a separate order and clinical indication.DESIGN: Prospective, nonrandomized, controlled design with an intervention.SETTING: The pediatric intensive care unit (PICU) at Primary Children's Medical Center, Salt Lake City, UT.PATI... | ['Cost Savings', 'Diagnostic Tests, Routine', 'Evidence-Based Medicine', 'Forms and Records Control', 'Hospitals, Pediatric', 'Humans', 'Intensive Care Units, Pediatric', 'Length of Stay', 'Medical Records', 'Patient Selection', "Practice Patterns, Physicians'", 'Prospective Studies', 'Radiography, Thoracic', 'Respirat... | 10,470,769 | [['N03.219.151.160.200'], ['E01.370.395'], ['H02.249.750', 'H02.403.200.400'], ['N04.452.758.708.200.400'], ['N02.278.421.556.437'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N02.278.388.493.390'], ['E02.760.400.480', 'N02.421.585.400.480'], ['E05.318.308.940.968', 'N04.452.859.564', 'N05.715.360.300.715.500',... | ['Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
Understanding the participation of breast screening among women born in predominantly Muslim countries living in Victoria, Australia from record-linkage data. | BACKGROUND: Early detection of breast cancer can improve survival rates and decrease mortality rates. This study investigates whether there are significant differences in participation in breast screening among women born in Muslim countries compared to women born in Non-Muslim countries and Australia.METHODS: Screenin... | ['Aged', 'Aged, 80 and over', 'Breast Neoplasms', 'Early Detection of Cancer', 'Emigrants and Immigrants', 'Female', 'Humans', 'Islam', 'Mass Screening', 'Middle Aged', 'Victoria'] | 32,764,828 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['C04.588.180', 'C17.800.090.500'], ['E01.390.500'], ['M01.189'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['K01.844.275'], ['E01.370.500', 'E05.318.308.980.438.580', 'N02.421.726.233.443', 'N05.715.360.300.800.438.500', 'N06.850.520.308.980.438.580', 'N06.850.780.... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Humanities [K]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Some examples of balloon technology in neurosurgery. | Examples are presented of the use of a compression balloon to treat trigeminal neuralgia, of a dilating balloon to release a web obstruction of the internal carotid artery, of detachable balloons to seal carotid-cavernous and vertebral-venous fistulas, of a temporary occlusive balloon to aid in thrombogenic treatment o... | ['Adolescent', 'Adult', 'Aged', 'Aneurysm', 'Arteriovenous Fistula', 'Brain Diseases', 'Carotid Arteries', 'Carotid Artery Diseases', 'Catheterization', 'Cerebral Angiography', 'Female', 'Humans', 'Male', 'Middle Aged', 'Neuralgia', 'Trigeminal Nerve'] | 7,359,186 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['C14.907.055'], ['C14.240.850.750.147', 'C14.240.850.984.750', 'C14.907.150.125', 'C14.907.933.555', 'C16.131.240.850.750.125', 'C23.300.575.950.250'], ['C10.228.140'], ['A07.015.114.186'], ['C10.228.140.300.200', 'C14.907.253.123'], ['E02.148', 'E05.157'], ['E01... | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Initial validation of a novel protein biomarker panel for active pediatric lupus nephritis. | Lupus nephritis (LN) is among the main determinants of poor prognosis in systemic lupus erythematosus (SLE). The objective of this study was to 1) isolate and identify proteins contained in the LN urinary protein signature (PS) of children with SLE; 2) assess the usefulness of the PS proteins for detecting activity of ... | ['Adolescent', 'Albuminuria', 'Arthritis, Juvenile', 'Biomarkers', 'Blood Proteins', 'Case-Control Studies', 'Ceruloplasmin', 'Enzyme-Linked Immunosorbent Assay', 'Female', 'Humans', 'Intramolecular Oxidoreductases', 'Lipocalins', 'Lupus Erythematosus, Systemic', 'Lupus Nephritis', 'Male', 'Nephelometry and Turbidimetr... | 19,218,887 | [['M01.060.057'], ['C12.777.934.734.269', 'C13.351.968.934.734.269', 'C23.888.942.750.269'], ['C05.550.114.122', 'C05.799.056', 'C17.300.775.049', 'C20.111.198'], ['D23.101'], ['D12.776.124'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['D08.811.682.226', 'D12.776.124.050.130', 'D12.... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Heart hexokinase: quaternary structure changes accompanying the binding of regulatory molecules. | Heart hexokinase monomer has a molecular weight of 97000 and so20,w 5.2 S. It exists in equilibrium with dimer of 194000 molecular weight and so20,w 8.1 S. The proportions of monomer and dimer presence of added ligands are 91% and 9% respectively. The existence of these forms may be demonstrated by separation on electr... | ['Adenosine Triphosphate', 'Animals', 'Binding Sites', 'Glucosephosphates', 'Hexokinase', 'Macromolecular Substances', 'Magnesium', 'Molecular Weight', 'Myocardium', 'Phosphates', 'Protein Binding', 'Protein Conformation', 'Swine'] | 1,183,436 | [['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['B01.050'], ['G02.111.570.120'], ['D09.894.417.448'], ['D08.811.913.696.620.300'], ['D05'], ['D01.268.552.437', 'D01.268.557.500', 'D01.552.547.500'], ['G02.494'], ['A02.633.580', 'A07.541.704', 'A10.690.552.750'], ['D01.029.260.700.675.37... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Ectopic production of HCG by a benign ovarian mature cystic teratoma simulating an extra-uterine pregnancy: a case report. | UNLABELLED: Physicians should consider a benign mature cystic teratoma in their differential diagnosis of a patient with an elevated serum human chorionic gonadotropin concentration.BACKGROUND: Following tubal ligation, a woman with amenorrhea and elevated serum human chorionic gonadotropin (HCG) concentrations may be ... | ['Adult', 'Biomarkers', 'Chorionic Gonadotropin', 'Diagnosis, Differential', 'Female', 'Humans', 'Ovarian Neoplasms', 'Ovariectomy', 'Pregnancy', 'Pregnancy, Ectopic', 'Teratoma', 'Treatment Outcome'] | 25,134,187 | [['M01.060.116'], ['D23.101'], ['D06.472.699.322.326', 'D06.472.699.649.367', 'D12.644.548.726.367', 'D12.776.780.400'], ['E01.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.322.455', 'C13.351.500.056.630.705', 'C13.351.937.418.685', 'C19.344.410', 'C19.391.630.705'], ['E04.270.282.685', 'E04.950.165... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Cardiac magnetic resonance imaging in Alstr?m syndrome. | BACKGROUND: A case series of the cardiac magnetic resonance imaging findings in seven adult Alstr?m patients.METHODS: Seven patients from the National Specialist Commissioning Group Centre for Alstr?m Disease, Torbay, England, UK, completed the cardiac magnetic resonance imaging protocol to assess cardiac structure and... | ['Adult', 'Cardiomyopathies', 'Female', 'Gadolinium', 'Heart Ventricles', 'Humans', 'Image Enhancement', 'Magnetic Resonance Imaging', 'Male', 'Ventricular Dysfunction, Left', 'Ventricular Dysfunction, Right', 'Young Adult'] | 19,515,241 | [['M01.060.116'], ['C14.280.238'], ['D01.268.558.362.484', 'D01.552.550.399.484'], ['A07.541.560'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.600.350', 'L01.224.308.380'], ['E01.370.350.825.500'], ['C14.280.945.900'], ['C14.280.945.910'], ['M01.060.116.815']] | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Four different methods comparison for extraction of astaxanthin from green alga Haematococcus pluvialis. | Haematococcus pluvialis is one of the potent organisms for production of astaxanthin. Up to now, no efficient method has been achieved due to its thick cell wall hindering solvent extraction of astaxanthin. In this study, four different methods, hydrochloric acid pretreatment followed by acetone extraction (HCl-ACE), h... | ['Chlorophyta', 'Chromatography, High Pressure Liquid', 'Liquid-Liquid Extraction', 'Magnetic Resonance Spectroscopy', 'Xanthophylls'] | 24,574,909 | [['B01.650.940.150'], ['E05.196.181.400.300'], ['E05.196.155.650'], ['E05.196.867.519'], ['D02.455.326.271.665.202.868', 'D02.455.426.392.368.367.379.249.887', 'D02.455.849.131.868', 'D23.767.261.887']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
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