Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Empyema thoracis: medical aspects of evaluation and treatment. | Empyema thoracis is a disease that, despite centuries of study, still causes significant morbidity and mortality. Sixty-five cases were seen at Brooke Army Medical Center over an 8-year period (March 1, 1985, through March 1, 1993). The majority of the patients were men, older than 50 years of age, with significant und... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Child', 'Child, Preschool', 'Empyema, Pleural', 'Female', 'Humans', 'Male', 'Middle Aged', 'Retrospective Studies'] | 7,973,893 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['M01.060.406'], ['M01.060.406.448'], ['C01.748.265', 'C01.830.305.310', 'C08.528.240', 'C08.730.265', 'C23.550.470.756.305.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.372.500.500.500', 'E05.318.3... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Rheumatoid arthritis treated with vegetarian diets. | The notion that dietary factors may influence rheumatoid arthritis (RA) has been a part of the folklore of the disease, but scientific support for this has been sparse. In a controlled, single-blind trial we tested the effect of fasting for 7-10 d, then consuming an individually adjusted, gluten-free, vegan diet for 3.... | ['Arthritis, Rheumatoid', 'Diet, Vegetarian', 'Fasting', 'Humans', 'Single-Blind Method'] | 10,479,237 | [['C05.550.114.154', 'C05.799.114', 'C17.300.775.099', 'C20.111.199'], ['E02.642.249.300', 'G07.203.650.240.300'], ['F01.145.407.400', 'G07.203.650.240.587', 'G07.203.650.353.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.370.850', 'N05.715.360.325.730', 'N06.850.520.445.850']] | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Salicylic acid increases drought adaptability of young olive trees by changes on redox status and ionome. | Different SA concentrations (10, 100 and 1000 ìM) were applied in young olive trees (Olea europaea L.) subjected to drought and rewatering. Plants treated with 10 ìM exhibited a close behavior to SA-starved plants. Although both 100 and 1000 ìM improved the balance between ROS production and scavenging, 100 ìM was more... | ['Antioxidants', 'Biomass', 'Droughts', 'Ions', 'Minerals', 'Nutrients', 'Olea', 'Oxidation-Reduction', 'Oxidative Stress', 'Photosynthesis', 'Plant Leaves', 'Plant Roots', 'Portugal', 'Reactive Oxygen Species', 'Salicylic Acid', 'Water'] | 31,207,492 | [['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['G16.500.275.157.100', 'N06.230.124.100'], ['G16.500.175.781', 'G16.500.750.775.154', 'N06.230.100.230.150'], ['D01.248.497'], ['D01.578'], ['G07.203.300.681', 'J02.500.681'], ['B01.650.940.800.575.912.250.583.640.666'], ['G02.700', 'G03.295.531'], ['G03.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Anatomy [A]', 'Geographicals [Z]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
Radiographic examination of edentulous mouths. | Many dentists routinely make radiographs of edentulous patients who request replacement dentures. In the American Dental Associations' Guide to Dental Health, the public is informed that "an x-ray examination is performed only when necessary, not as a routine procedure, and only when the dentist believes such an examin... | ['Aged', 'Denture, Complete', 'Humans', 'Incidence', 'Jaw Diseases', 'Mouth, Edentulous', 'New York', 'Patient Care Planning', 'Prospective Studies', 'Radiography, Panoramic', 'Time Factors', 'Tooth Diseases'] | 2,391,668 | [['M01.060.116.100'], ['E06.780.346.760.775', 'E07.695.190.200.205'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.985.525.375'], ['C05.500', 'C07.320'], ['C07.465.550', 'C07.793.597'], ['Z01.107.567.875.075.437', 'Z0... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Diseases [C]', 'Geographicals [Z]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Accuracy of preoperative studies in staging nonseminomatous germ cell testicular tumors. | The preoperative staging procedures used in 45 patients with surgical Stage I and Stage II nonseminomatous germ cell tumors of the testis were analyzed retrospectively. Our results indicate that gallium-67-citrate scan and supraclavicular lymph node biopsy add little information in the routine preoperative evaluation o... | ['Humans', 'Lymph Nodes', 'Lymphography', 'Male', 'Neoplasm Staging', 'Neoplasms, Germ Cell and Embryonal', 'Retrospective Studies', 'Testicular Neoplasms', 'Urography'] | 213,865 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['A10.549.400', 'A15.382.520.604.412'], ['E01.370.350.700.475'], ['E01.789.625'], ['C04.557.465'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.520.450.500.500.500', 'N06.850.520.450.500.75... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Precision placement of separated dairy sludge improves early phosphorus nutrition and growth in corn ( L.). | Efficient use of manure nutrients by crops is necessary to minimize losses to the environment. This field study examined the possibility of replacing side-banded mineral P with precision-placed high-P sludge (6.2-11.0% dry matter) obtained after settling dairy manure slurry. The sludge was injected at about 30 kg P ha ... | ['Dairying', 'Fertilizers', 'Mycorrhizae', 'Phosphorus', 'Plant Roots', 'Sewage', 'Zea mays'] | 22,370,420 | [['J01.040.246'], ['D27.720.031.400'], ['A18.400.525', 'A19.690', 'B01.300.655', 'B05.550'], ['D01.268.666'], ['A18.400'], ['D20.944.932.500'], ['B01.650.940.800.575.912.250.822.966']] | ['Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Histone deacetylase inhibition enhances the lymphomacidal activity of the anti-CD22 monoclonal antibody HB22.7. | HB22.7, an anti-CD22 monoclonal antibody has shown consistent preclinical activity against non-Hodgkin lymphoma (NHL). Histone deacetylase inhibitors (HDACi) have demonstrated efficacy in lymphoma and can modulate cell surface receptor expression. To augment the lymphomacidal activity of HB22.7 we examined the combinat... | ['Animals', 'Antibodies, Monoclonal', 'Cell Line, Tumor', 'Female', 'Flow Cytometry', 'Histone Deacetylase Inhibitors', 'Humans', 'Lymphoma, Non-Hodgkin', 'Mice', 'Mice, Nude', 'Sialic Acid Binding Ig-like Lectin 2'] | 25,241,275 | [['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['A11.251.210.190', 'A11.251.860.180'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.200.500.386.350', 'E05.242.363.342', 'E05.242.386.350'], ... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cetyltrimethylammonium chloride as a surfactant buffer additive for reversed-polarity capillary electrophoresis-electrospray mass spectrometry. | The rapid analysis of picomole quantities of various cationic molecules (laser dyes, tripeptides and larger bioactive peptides) has been achieved by on-line capillary electrophoresis-electrospray mass spectrometry (CE-ES-MS). Use of the cationic surfactant, cetyltrimethylammonium chloride (CTAC) in the CE buffer greatl... | ['Amino Acid Sequence', 'Buffers', 'Cetrimonium', 'Cetrimonium Compounds', 'Electrophoresis', 'Mass Spectrometry', 'Molecular Sequence Data', 'Oligopeptides', 'Rhodamines', 'Surface-Active Agents'] | 8,287,131 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D27.720.470.280'], ['D02.092.877.883.111.500', 'D02.675.276.190.500'], ['D02.092.877.883.111', 'D02.675.276.190'], ['E05.196.401', 'E05.301.300'], ['E05.196.566'], ['L01.453.245.667'], ['D12.644.456'], ['D03.633.300.953.600'], ['D27.720.877']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Unsaturated fatty acids inhibit the expression of tumor suppressor phosphatase and tensin homolog (PTEN) via microRNA-21 up-regulation in hepatocytes. | UNLABELLED: Phosphatase and tensin homolog (PTEN) is a regulator of phosphoinositide 3-kinase signaling and an important tumor suppressor mutated/deleted in human cancers. PTEN deletion in the liver leads to insulin resistance, steatosis, inflammation, and cancer. We recently demonstrated that unsaturated fatty acids t... | ['Animals', 'Cell Line, Tumor', 'Down-Regulation', 'Epigenesis, Genetic', 'Fatty Acids, Nonesterified', 'Gene Expression Regulation', 'Hepatocytes', 'Humans', 'MicroRNAs', 'Oleic Acid', 'PTEN Phosphohydrolase', 'Promoter Regions, Genetic', 'Protein Kinases', 'RNA, Messenger', 'Rats', 'Rats, Wistar', 'TOR Serine-Threoni... | 19,072,831 | [['B01.050'], ['A11.251.210.190', 'A11.251.860.180'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['G05.308.203'], ['D10.251.310'], ['G05.308'], ['A11.436.348'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D13.150.650.319', 'D13.444.735.150.319', 'D13.444.735.790.552.500'], ['D10.251.355.325.600.525'], ['... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Evaluating how electronic charting affects resident productivity. | Electronic medical records (EMRs) are becoming standard to improve the communication of information and longevity of patient records. Using an EMR in the emergency department (ED) could potentially slow residents evaluating patients. We evaluated how introducing an EMR affected resident productivity in an academic ED. ... | ['Efficiency, Organizational', 'Emergency Medicine', 'Humans', 'Internship and Residency', 'Massachusetts', 'Medical Records Systems, Computerized', 'Retrospective Studies'] | 23,334,927 | [['N04.452.209.500'], ['H02.403.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I02.358.337.350.500', 'I02.358.399.350.750'], ['Z01.107.567.875.550.510'], ['E05.318.308.940.968.625', 'L01.313.500.750.300.695', 'N04.452.859.564.650', 'N05.715.360.300.715.500.530', 'N06.850.520.308.940.968.625'], ['E05.318.372.... | ['Health Care [N]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 |
Evaluating the sensitivity of Halcyon's automatic transit image acquisition for treatment error detection: A phantom study using static IMRT. | PURPOSE: The Varian Halcyon™ electronic portal imaging detector is always in-line with the beam and automatically acquires transit images for every patient with full-field coverage. These images could be used for "every patient, every monitor unit" quality assurance (QA) and eventually adaptive radiotherapy. This study... | ['Algorithms', 'Calibration', 'Humans', 'Image Processing, Computer-Assisted', 'Male', 'Organs at Risk', 'Particle Accelerators', 'Phantoms, Imaging', 'Prostatic Neoplasms', 'Quality Assurance, Health Care', 'Radiotherapy Dosage', 'Radiotherapy Planning, Computer-Assisted', 'Radiotherapy, Intensity-Modulated'] | 31,587,477 | [['G17.035', 'L01.224.050'], ['E05.978.155'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['A01.635'], ['E07.710.680'], ['E07.671'], ['C04.588.945.440.770', 'C12.294.260.750', 'C12.294.565.625', 'C12.758.409.750'], ['N04.761.700', 'N05.700'], ['E02.815.639'], ['E02.950.825', 'L01.313.500.750.100.7... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Dietary intake of phytoestrogen is associated with increased circulating endothelial progenitor cells in patients with cardiovascular disease. | Endogenous estrogen is known to positively influence the level and functionality of endothelial progenitor cells (EPC). However, the effect of phytoestrogen on EPC is unknown. Isoflavone is a major component of phytoestrogen. This study aims to investigate if the intake of isoflavone has any impact on the circulating l... | ['Aged', 'Cardiovascular Diseases', 'Dietary Supplements', 'Endothelial Cells', 'Endothelium, Vascular', 'Female', 'Flow Cytometry', 'Follow-Up Studies', 'Humans', 'Male', 'Phytoestrogens', 'Retrospective Studies', 'Stem Cells', 'Surveys and Questionnaires'] | 21,450,646 | [['M01.060.116.100'], ['C14'], ['G07.203.300.456', 'J02.500.456'], ['A11.436.275'], ['A07.015.700.500', 'A10.272.491.355'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.200.500.386.350', 'E05.242.363.342', 'E05.242.386.350'], ['E05.318.372.500.750.249... | ['Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
HHV-8-associated haemophagocytic lymphohistiocytosis in a patient with advanced AIDS. | We present a patient with advanced AIDS admitted with recurrent shock of unclear aetiology, fevers, altered mental status and refractory cytopenias. His case posed a diagnostic challenge because evaluation of septic shock in the setting of advanced AIDS requires a time-consuming work-up for broad infectious aetiologies... | ['Acquired Immunodeficiency Syndrome', 'Anti-Inflammatory Agents', 'Bone Marrow', 'CD4 Lymphocyte Count', 'Dexamethasone', 'Diagnosis, Differential', 'Fatal Outcome', 'Fever', 'Herpesviridae Infections', 'Herpesvirus 8, Human', 'Humans', 'Lymphohistiocytosis, Hemophagocytic', 'Male', 'Middle Aged', 'Shock, Septic'] | 29,275,390 | [['C01.221.250.875.040', 'C01.221.812.640.400.040', 'C01.778.640.400.040', 'C01.925.782.815.616.400.040', 'C01.925.813.400.040', 'C01.925.839.040', 'C20.673.480.040'], ['D27.505.954.158'], ['A15.382.216'], ['E01.370.225.500.195.107.595.500.150', 'E01.370.225.625.107.595.500.150', 'E05.200.500.195.107.595.500.150', 'E05... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Treatment of secondary hyperparathyroidism with ultrasonographically guided percutaneous radiofrequency thermoablation. | We present a case of a 63-year-old woman with a recurrent secondary hyperparathyroidism hyperplasia with absolute contraindication for surgery, treated in 2 sessions with percutaneous ultrasonographically guided radiofrequency tissue ablation. The complete pathologic tissue ablation was confirmed by contrast-enhanced u... | ['Catheter Ablation', 'Female', 'Follow-Up Studies', 'Humans', 'Hyperparathyroidism, Secondary', 'Middle Aged', 'Parathyroidectomy', 'Ultrasonography'] | 16,773,015 | [['E02.808.750.500', 'E04.014.760.500'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C19.642.355.480'], ['M01.060.116.630'], ['E04.270.694'], ['E01.370.350.850']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Pyruvate is superior to reverse visceral hypoperfusion in peritoneal resuscitation from hemorrhagic shock in rats. | AIMS: The objective of this study was to investigate the effects of pyruvate-containing fluids on peritoneal resuscitation (PR), following intravenous fluid resuscitation from hemorrhagic shock (HS) in rats.METHODS: One hundred rats following 1-h HS with mean arterial pressure 35 ± 5 mmHg were randomly assigned to five... | ['Animals', 'Biomarkers', 'Blood Pressure', 'Body Water', 'Fluid Therapy', 'Infusions, Parenteral', 'Intestinal Mucosa', 'Kidney', 'Liver', 'Male', 'Pyruvic Acid', 'Rats', 'Rats, Sprague-Dawley', 'Regional Blood Flow', 'Rehydration Solutions', 'Resuscitation', 'Shock, Hemorrhagic', 'Splanchnic Circulation', 'Zonula Occ... | 24,365,878 | [['B01.050'], ['D23.101'], ['E01.370.600.875.249', 'G09.330.380.076'], ['A12.207.200'], ['E02.319.360'], ['E02.319.267.510'], ['A03.556.124.369', 'A10.615.550.444'], ['A05.810.453'], ['A03.620'], ['D02.241.755.812.800'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.750'], ['G09... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Continuous estimation of cerebral metabolic changes. | The purpose of the present research has been to estimate rapid metabolic changes. By means of mass spectrometry, the partial pressure of physiological gases are continuously analyzed in a local area of the brain tissue. The method we have developed allows quantitative measurement of the variables with a response time o... | ['Animals', 'Blood Pressure', 'Brain', 'Carbon Dioxide', 'Cerebrovascular Circulation', 'Mass Spectrometry', 'Oxygen', 'Oxygen Consumption', 'Partial Pressure', 'Rabbits'] | 6,790,284 | [['B01.050'], ['E01.370.600.875.249', 'G09.330.380.076'], ['A08.186.211'], ['D01.200.200', 'D01.362.150', 'D01.650.550.200'], ['G09.330.100.159'], ['E05.196.566'], ['D01.268.185.550', 'D01.362.670'], ['G03.680'], ['G01.374.715.714'], ['B01.050.150.900.649.313.968.700']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 2. Mechanism of inhibition and structure-based improvement of pharmaceutical properties. | The interaction between leukocyte function-associated antigen-1 (LFA-1) and intracellular adhesion molecule-1 (ICAM-1) has been implicated in inflammatory and immune diseases. Recently, a novel series of p-arylthio cinnamides has been described as potent antagonists of the LFA-1/ICAM-1 interaction. These compounds were... | ['Allosteric Regulation', 'Amides', 'Animals', 'Cinnamates', 'Combinatorial Chemistry Techniques', 'Intercellular Adhesion Molecule-1', 'Ligands', 'Lymphocyte Function-Associated Antigen-1', 'Magnetic Resonance Spectroscopy', 'Models, Molecular', 'Rats', 'Solubility', 'Structure-Activity Relationship'] | 11,312,920 | [['G02.111.044'], ['D02.065'], ['B01.050'], ['D02.241.223.200'], ['E05.197.312', 'J01.897.836.249.249'], ['D12.776.395.550.200.450', 'D12.776.543.550.200.450', 'D23.050.301.350.450'], ['D27.720.470.480'], ['D12.776.395.550.200.074.937', 'D12.776.395.550.200.625.550', 'D12.776.543.550.200.093.937', 'D12.776.543.550.200.... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Does quantitative tRNA adaptation to codon content in mRNA optimize the ribosomal translation efficiency? Proposal for a translation system model. | Neither a dynamic nor an energetic approach of the translation process has taken into account that intracellular levels of iso-tRNA species are adapted or adjusted to the codon frequency of mRNA being decoded (Bombyx mori silk gland, rabbit reticulocyte). A critical study of available experimental data suggests that th... | ['Codon', 'Kinetics', 'Models, Genetic', 'Peptide Chain Elongation, Translational', 'Protein Biosynthesis', 'RNA, Messenger', 'RNA, Transfer'] | 7,225,463 | [['D13.444.735.544.355', 'G05.360.335.355', 'G05.360.340.024.340.137.190'], ['G01.374.661', 'G02.111.490'], ['E05.599.395.397'], ['G02.111.660.871.640', 'G03.734.871.640'], ['G02.111.660.871', 'G03.734.871', 'G05.297.670'], ['D13.444.735.544'], ['D13.444.735.757']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
CrABCA2 Facilitates Triacylglycerol Accumulation in Chlamydomonas reinhardtii | The microalga Chlamydomonas reinhardtii accumulates triacylglycerols (TAGs) in lipid droplets under stress conditions, such as nitrogen starvation. TAG biosynthesis occurs mainly at the endoplasmic reticulum (ER) and requires fatty acid (FA) substrates supplied from chloroplasts. How FAs are transferred from chloroplas... | ['ATP-Binding Cassette Transporters', 'Arabidopsis', 'Chlamydomonas reinhardtii', 'Chloroplasts', 'Endoplasmic Reticulum', 'Fatty Acids', 'Gene Expression Regulation', 'Lipid Droplets', 'Lipid Metabolism', 'Microscopy, Electron, Transmission', 'Mutation', 'Nitrogen', 'Phylogeny', 'Sequence Alignment', 'Triglycerides'] | 31,910,336 | [['D12.776.157.530.100', 'D12.776.395.550.020', 'D12.776.543.550.192', 'D12.776.543.585.100'], ['B01.650.940.800.575.912.250.157.100'], ['B01.650.940.150.385.650'], ['A11.284.430.214.190.875.700.140'], ['A11.284.430.214.190.875.248'], ['D10.251'], ['G05.308'], ['A11.284.430.214.190.875.393'], ['G03.458'], ['E01.370.350... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Younger Stroke Patients With Large Pretreatment Diffusion-Weighted Imaging Lesions May Benefit From Endovascular Treatment. | BACKGROUND AND PURPOSE: Lesion volume on diffusion-weighted magnetic resonance imaging (DWI) before acute stroke therapy is a predictor of outcome. Therefore, patients with large volumes are often excluded from therapy. The aim of this study was to analyze the impact of endovascular treatment in patients with large DWI... | ['Age Factors', 'Aged', 'Aged, 80 and over', 'Arterial Occlusive Diseases', 'Carotid Artery, Internal', 'Cerebral Hemorrhage', 'Cerebral Infarction', 'Cerebrovascular Circulation', 'Diffusion Magnetic Resonance Imaging', 'Female', 'Humans', 'Male', 'Middle Aged', 'Middle Cerebral Artery', 'Outcome Assessment, Health Ca... | 26,251,252 | [['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C14.907.137'], ['A07.015.114.186.200.230'], ['C10.228.140.300.535.200', 'C14.907.253.573.200', 'C23.550.414.913.100'], ['C10.228.140.300.150.477.200', 'C10.228.140.300.775.200.200', 'C14.907.253.092.477.200', 'C14.907.253.855.200.2... | ['Health Care [N]', 'Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Establishment and characterization of four Sinclair swine cutaneous malignant melanoma cell lines. | Cutaneous malignant melanoma of Sinclair Swine (SSCM) is a heritable, congenital neoplasm which either proves fatal to the neonatal animal or undergoes spontaneous regression. Four SSCM cell lines, UISO-SSCM-433, UISO-SSCM-438, UISO-SSCM-5052, and UISO-SSCM-8093, were derived from biopsy specimens of primary tumors rem... | ['Animals', 'Cell Line', 'Chromosome Aberrations', 'Female', 'Karyotyping', 'Male', 'Melanoma', 'Mice', 'Mice, Nude', 'Monophenol Monooxygenase', 'Neoplasm Transplantation', 'Skin Neoplasms', 'Swine', 'Swine Diseases'] | 1,638,485 | [['B01.050'], ['A11.251.210'], ['C23.550.210', 'G05.365.590.175'], ['E01.370.225.500.385.315', 'E05.200.500.385.315', 'E05.242.385.315', 'E05.393.285.475'], ['C04.557.465.625.650.510', 'C04.557.580.625.650.510', 'C04.557.665.510'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.150.900.649.313.992.635.505.500.5... | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Apoptosis induction by Pleurotus sajor-caju (Fr.) Singer extracts on colorectal cancer cell lines. | Pleurotus sajor-caju (PSC) is an edible mushroom used in food supplements, presenting antitumor properties through induction of cell death pathways. The PSC potential against colorectal cancer was analyzed by exposing HCT116wt cells to different PSC extracts. The PSC n-hexane extract (PSC-hex) showed the highest cytoto... | ['Antineoplastic Agents', 'Apoptosis', 'Caspase 3', 'Cell Division', 'Cell Line', 'Colorectal Neoplasms', 'Dietary Supplements', 'Ergosterol', 'G2 Phase', 'HCT116 Cells', 'Humans', 'Hydrophobic and Hydrophilic Interactions', 'Inhibitory Concentration 50', 'Membrane Potential, Mitochondrial', 'Molecular Docking Simulati... | 29,337,231 | [['D27.505.954.248'], ['G04.146.954.035'], ['D08.811.277.656.262.500.126.350.300', 'D08.811.277.656.300.200.126.350.300', 'D12.644.360.075.405.350.300', 'D12.776.476.075.405.350.300'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.251.210'], ['C04.588.274.476.411.307', 'C06.301.371.411... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Regulation of matrix metalloproteinases (MMPS) and their inhibitors (TIMPS) during mouse peri-implantation: role of nitric oxide. | Nitric oxide (NO) is believed to play pivotal roles in embryo implantation. The purpose of this study was to investigate the effect of NO on matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs), as well as the mechanism of NO during mouse implantation. Nitric oxide synthase (NOS) inhibitor, L-NAME was a... | ['Animals', 'Embryo Implantation', 'Enzyme Inhibitors', 'Female', 'Gene Expression Regulation, Developmental', 'In Situ Hybridization', 'Matrix Metalloproteinase Inhibitors', 'Matrix Metalloproteinases', 'Mice', 'Mice, Inbred Strains', 'NG-Nitroarginine Methyl Ester', 'Nitric Oxide', 'Pregnancy', 'RNA, Messenger', 'Tis... | 15,028,415 | [['B01.050'], ['G08.686.784.170.104.500'], ['D27.505.519.389'], ['G05.308.310'], ['E01.370.225.500.620.670.325', 'E01.370.225.750.600.670.325', 'E05.200.500.620.670.325', 'E05.200.750.600.670.325', 'E05.393.661.475'], ['D27.505.519.389.745.610'], ['D08.811.277.656.300.480.525', 'D08.811.277.656.675.374.525'], ['B01.050... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Spinal nerve root herniation into a pseudomeningocele associated with lumbar spondylolysis: a case report. | A 38-year-old man presented with low back pain and sciatica on the left side. Magnetic resonance imaging showed spinal nerve root herniation into a pseudomeningocele associated with lumbar spondylolysis. After closure of the dural defect, the sciatic pain was relieved and subsequently the patient was able to return to ... | ['Adult', 'Humans', 'Lumbar Vertebrae', 'Male', 'Meningocele', 'Spinal Nerve Roots', 'Spondylolysis'] | 21,187,554 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.232.834.519'], ['C10.500.680.598', 'C16.131.666.680.598', 'C23.300.707.968'], ['A08.800.800.720.725'], ['C05.116.900.938.500']] | ['Named Groups [M]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Gastric biopsies: increasing the yield. | Gastric biopsies can provide useful information beyond the identification of inflammation or Helicobacter organisms. The key to maximizing the diagnostic yield is providing sufficient context, adequate sampling, and good communication. Clinical information including medical history, surgical procedures, endoscopic impr... | ['Biopsy', 'Coloring Agents', 'Gastroscopy', 'Humans', 'Specimen Handling', 'Stomach', 'Stomach Diseases'] | 17,296,525 | [['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['D27.720.233'], ['E01.370.372.250.250.325', 'E01.370.388.250.250.250.320', 'E04.210.240.250.320', 'E04.502.250.250.250.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Skills-building methods to prevent smoking by adolescents. | This study evaluated cigarette smoking prevention methods with a sample of adolescent females and males. Arranged by school, 331 informed and consenting sixth graders were randomly divided into four groups: 1) pretest, skills-building methods, posttest; 2) pretest, discussion methods, posttest; 3) pretest and posttest;... | ['Adolescent', 'Evaluation Studies as Topic', 'Female', 'History, Ancient', 'Humans', 'Male', 'Psychology, Adolescent', 'Smoking Prevention', 'Time Factors'] | 4,055,463 | [['M01.060.057'], ['E05.337', 'N05.715.360.335'], ['K01.400.470'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F04.096.628.065'], ['I02.233.332.812', 'N02.421.726.407.840'], ['G01.910.857']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Humanities [K]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Human immune memory to yellow fever and smallpox vaccination. | BACKGROUND: Establishment of immunological memory is a hallmark of adaptive immune responses and the biological mechanism for the success of vaccines. However, in humans, much of our knowledge about adaptive immune responses derives from studies of chronic viral infections.OBJECTIVE: Here, we summarize the work of our ... | ['Antibodies, Viral', 'Antibody Formation', 'Antigen-Presenting Cells', 'B-Lymphocytes', 'CD8-Positive T-Lymphocytes', 'Cytokines', 'Humans', 'Immunologic Memory', 'Smallpox Vaccine', 'Vaccines, Attenuated', 'Variola virus', 'Yellow Fever Vaccine', 'Yellow fever virus'] | 19,052,852 | [['D12.776.124.486.485.114.254', 'D12.776.124.790.651.114.254', 'D12.776.377.715.548.114.254'], ['G12.450.050.370.250'], ['A11.066', 'A15.382.066'], ['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['A11.118.637.555.567.569.220', 'A15.145.229.637.5... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Yes-associated protein isoform 1 (Yap1) promotes cardiomyocyte survival and growth to protect against myocardial ischemic injury. | Yap1 is an important regulator of cardiomyocyte proliferation and embryonic heart development, yet the function of endogenous Yap1 in the adult heart remains unknown. We studied the role of Yap1 in maintaining basal cardiac function and in modulating injury after chronic myocardial infarction (MI). Cardiomyocyte-specif... | ['Adaptor Proteins, Signal Transducing', 'Animals', 'Apoptosis', 'Cardiomegaly', 'Cell Cycle Proteins', 'Cell Survival', 'Cells, Cultured', 'Chronic Disease', 'Gene Expression Regulation', 'Heterozygote', 'Hydrogen Peroxide', 'Mice', 'Mice, Transgenic', 'Muscle Proteins', 'Myocardial Ischemia', 'Myocardium', 'Myocytes,... | 23,275,380 | [['D12.644.360.024', 'D12.776.157.057', 'D12.776.476.024'], ['B01.050'], ['G04.146.954.035'], ['C14.280.195', 'C23.300.775.250'], ['D12.776.167'], ['G04.346'], ['A11.251'], ['C23.550.291.500'], ['G05.308'], ['G05.380.383'], ['D01.248.497.158.685.750.424', 'D01.339.431.374.424', 'D01.650.550.750.400', 'D02.389.338.253']... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Transradial intervention of iliac and superficial femoral artery disease is feasible. | BACKGROUND: Percutaneous intervention of iliac artery (IA) and superficial femoral artery (SFA) disease is often performed via ipsilateral or contralateral femoral access. However, this approach may be difficult in patients with severe iliac or common femoral artery atherosclerosis, morbid obesity, or conditions prohib... | ['Aged', 'Aged, 80 and over', 'Atherosclerosis', 'Cardiac Catheterization', 'Catheterization', 'Female', 'Femoral Artery', 'Humans', 'Iliac Artery', 'Male', 'Middle Aged', 'Outcome and Process Assessment, Health Care', 'Peripheral Vascular Diseases', 'Radial Artery', 'Stents', 'Treatment Outcome'] | 18,705,637 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['C14.907.137.126.307'], ['E01.370.370.380.140', 'E02.148.442', 'E05.157.250'], ['E02.148', 'E05.157'], ['A07.015.114.351'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A07.015.114.444'], ['M01.060.116.630'], ['N04.761.559', 'N05.715.360.575'], ['C14.907.617'], ['A0... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Brief Report: Abacavir/Lamivudine and Tenofovir/Emtricitabine in Pregnant Women With HIV: Laboratory and Clinical Outcomes in an Observational National Study. | BACKGROUND: Abacavir-lamivudine (ABC/3TC) and tenofovir-emtricitabine (TDF/FTC) represent in the guidelines of several countries, including Italy and United States, the preferred nucleoside/nucleotide backbones of antiretroviral regimens. We assessed their profile in pregnancy using data from a national observational s... | ['AIDS-Associated Nephropathy', 'Adult', 'Anti-HIV Agents', 'Antiretroviral Therapy, Highly Active', 'CD4 Lymphocyte Count', 'Cesarean Section', 'Cholesterol', 'Dideoxynucleosides', 'Drug Combinations', 'Emtricitabine', 'Female', 'HIV Infections', 'HIV-1', 'Hemoglobins', 'Humans', 'Hypertension', 'Lamivudine', 'Lipopro... | 29,406,430 | [['C01.221.250.875.050', 'C01.221.812.640.400.072', 'C01.778.640.400.072', 'C01.925.782.815.616.400.050', 'C01.925.813.400.072', 'C12.777.419.050', 'C13.351.968.419.050', 'C20.673.480.050'], ['M01.060.116'], ['D27.505.954.122.388.077.088'], ['E02.319.310.075'], ['E01.370.225.500.195.107.595.500.150', 'E01.370.225.625.1... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The dynamics of elderly support. The transmission of solidarity patterns between generations. | This paper analyses the support given to the handicapped elderly by their children on the basis of a large survey done in France where both the elderly and their middle-aged children were interviewed. These data allow us to address such questions as: "Who helps?", "Who receives help?" and "According to what principles?... | ['Adult', 'Aged', 'Aged, 80 and over', 'Aging', 'Caregivers', 'Female', 'Forecasting', 'Germany', 'Humans', 'Intergenerational Relations', 'Male', 'Middle Aged', 'Social Support', 'Social Welfare'] | 11,310,233 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['G07.345.124'], ['M01.085', 'M01.526.485.200', 'N02.360.200'], ['I01.320'], ['Z01.542.315'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.263.370.110', 'F01.829.401.190'], ['M01.060.116.630'], ['I01.880.853.500.600'], ['I01.880.787']] | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Safety and efficacy of topical cidofovir to treat high-grade perianal and vulvar intraepithelial neoplasia in HIV-positive men and women. | OBJECTIVE: To evaluate the safety and efficacy of topical cidofovir for treatment of high-grade squamous perianal intraepithelial neoplasia (PAIN) and vulvar intraepithelial neoplasia (VIN) lesions in HIV-positive individuals.DESIGN: Phase IIa prospective multicenter trial conducted at eight clinical sites through the ... | ['Acquired Immunodeficiency Syndrome', 'Administration, Cutaneous', 'Adult', 'Aged', 'Antiviral Agents', 'Anus Neoplasms', 'CD4 Lymphocyte Count', 'Carcinoma in Situ', 'Cidofovir', 'Cyclin-Dependent Kinase Inhibitor p16', 'Cytosine', 'Dose-Response Relationship, Drug', 'Female', 'Follow-Up Studies', 'Humans', 'Male', '... | 23,032,420 | [['C01.221.250.875.040', 'C01.221.812.640.400.040', 'C01.778.640.400.040', 'C01.925.782.815.616.400.040', 'C01.925.813.400.040', 'C01.925.839.040', 'C20.673.480.040'], ['E02.319.267.120.060'], ['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.122.388'], ['C04.588.274.476.411.307.790.040', 'C06.301.371.411.307.790.040... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Nasolabial Changes Following Double Jaw Surgery. | BACKGROUND: This study aimed to analyze 3-dimensional nasolabial soft tissue changes following double jaw surgery with Le Fort I maxillary advancement and relate them to underlying surgical movements.METHODS: Pre- and post-surgical cone-beam computed tomography images of 37 maxillomandibular surgery patients with ?2 mm... | ['Adolescent', 'Adult', 'Cone-Beam Computed Tomography', 'Face', 'Female', 'Humans', 'Imaging, Three-Dimensional', 'Male', 'Maxilla', 'Middle Aged', 'Orthognathic Surgical Procedures', 'Young Adult'] | 31,689,731 | [['M01.060.057'], ['M01.060.116'], ['E01.370.350.700.810.810.490', 'E01.370.350.825.810.810.399'], ['A01.456.505'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.400', 'L01.224.308.410'], ['A02.835.232.781.324.502.645', 'A14.521.645'], ['M01.060.116.630'], ['E04.545.562', 'E04.555.580.289', 'E06.645.56... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Information Science [L]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Mercury concentrations in scalp hair as an environmental contamination index from foods in Korea. | Relationships have been established between the mercury (Hg) levels in human scalp hair and environmental or dietary mercury exposures. The average value of total mercury (THg) in scalp hair of male residents in Seoul city was 1.66 +/- 1.10 ppm (+/- SD) and for methylmercury (MeHg) was 1.02 +/- 0.72 ppm (61% of total H... | ['Adolescent', 'Adult', 'Age Factors', 'Child', 'Environmental Exposure', 'Environmental Pollutants', 'Female', 'Food Contamination', 'Hair', 'Humans', 'Korea', 'Male', 'Mercury', 'Middle Aged', 'Occupational Exposure', 'Sex Factors'] | 10,592,943 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.406'], ['N06.850.460.350'], ['D27.888.284'], ['J01.576.423.850.730.500.249', 'N06.850.460.400', 'N06.850.601.500.249'], ['A17.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.474.557', 'Z01.586.407'], ['D01.268.556.504... | ['Named Groups [M]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Organisms [B]', 'Geographicals [Z]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
Oxidative DNA damage in retinopathy of prematurity. | PURPOSE: This study examines the levels of oxidative damage in patients with retinopathy of prematurity (ROP).METHODS: Fifty patients were recruited with a birthweight below 1500 g or gestational age below 32 weeks. The cases were classified into those who developed ROP (n=25) and those without ROP (n=25). The authors ... | ["8-Hydroxy-2'-Deoxyguanosine", 'Biomarkers', 'Birth Weight', 'Chromatography, High Pressure Liquid', 'DNA Damage', 'Deoxyguanosine', 'Gestational Age', 'Humans', 'Infant', 'Infant, Newborn', 'Infant, Very Low Birth Weight', 'Leukocytes', 'Lipid Peroxidation', 'Malondialdehyde', 'Neonatal Screening', 'Oxidative Stress'... | 19,123,153 | [['D03.633.100.759.590.454.240.500', 'D13.570.230.360.500', 'D13.570.583.454.240.500'], ['D23.101'], ['C23.888.144.186', 'E01.370.600.115.100.160.120.186', 'E05.041.124.160.750.149', 'G07.100.100.160.120.186', 'G07.345.249.314.120.186'], ['E05.196.181.400.300'], ['G05.200'], ['D03.633.100.759.590.454.240', 'D13.570.230... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Named Groups [M]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Stabilization of G-quadruplex DNA by highly selective ligands via click chemistry. | A series of G-quadruplex stabilizing compounds have been prepared via click chemistry employing the Cu(I)-catalyzed Huisgen reaction. These compounds were shown to bind tightly to G-quadruplex DNA even in the presence of competing high concentrations of duplex DNA. Furthermore, a modified TRAP assay has shown that some... | ['DNA', 'Fluorescence Resonance Energy Transfer', 'G-Quadruplexes', 'Ligands', 'Models, Chemical', 'Molecular Structure', 'Temperature'] | 17,165,715 | [['D13.444.308'], ['E05.196.712.516.600.676.500', 'G01.154.240.280', 'G02.111.255.280'], ['G02.111.570.820.486.550', 'G05.360.580.550'], ['D27.720.470.480'], ['E05.599.495'], ['G02.111.570', 'G02.466'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.150.450', 'N06.230.300.100.725.710']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Antisense suppression of transferrin receptor gene expression in a human hepatoma cell (HuH-7) line. | A recombinant plasmid carrying human transferrin receptor cDNA in reverse orientation downstream from the human cytomegalovirus immediate early promoter/enhancer element was introduced into the HuH-7 human hepatoma cell line by lipofection. Cell surface transferrin binding and iron uptake from transferrin each decrease... | ['Base Sequence', 'Blotting, Northern', 'Blotting, Southern', 'Carcinoma, Hepatocellular', 'Gene Expression', 'Genetic Vectors', 'Humans', 'Liver Neoplasms', 'Molecular Sequence Data', 'Oligonucleotides, Antisense', 'Receptors, Transferrin', 'Time Factors', 'Transcription, Genetic', 'Tumor Cells, Cultured'] | 8,380,064 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.196.401.095', 'E05.301.300.074', 'E05.601.100'], ['E05.196.401.114', 'E05.301.300.087', 'E05.601.150'], ['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['G05.297'], ['G05.360.337'], ['B01.050.150.900.649.313.988.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Relation between total serum IgE levels and IgE antibody production in rats. | Five different rat strains were immunized with 100 microgram ovalbumin and 1 mg Al (OH)3. A good correlation was found between the total serum IgE level of a rat strain before immunization and the IgE antibody production. Good IgE antibody-producing strains had high total serum IgE levels and vice versa. A discordance ... | ['Animals', 'Antibody Formation', 'Immunization', 'Immunoglobulin E', 'Male', 'Rats', 'Rats, Inbred BN'] | 422,288 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cancer-associated genes can affect somatic intrachromosomal recombination early in carcinogenesis. | The pKZ1 recombination mutagenesis model has provided a sensitive assay where we study somatic intrachromosomal recombination (SICR) as a mutation end-point. SICR is associated with non-homologous end-joining repair of double-strand breaks and can result in chromosomal inversions and deletions, both of which are common... | ['Animals', 'Chromosome Aberrations', 'Chromosome Inversion', 'DNA-Binding Proteins', 'Down-Regulation', 'Gene Deletion', 'Genotype', 'Male', 'Mice', 'Mice, Transgenic', 'MutS Homolog 2 Protein', 'Mutagenesis', 'Neoplasms', 'Prostate', 'Proto-Oncogene Proteins', 'Proto-Oncogene Proteins c-myc', 'Proto-Oncogenes', 'Rece... | 15,135,636 | [['B01.050'], ['C23.550.210', 'G05.365.590.175'], ['C23.550.210.190', 'G05.365.590.175.190', 'G05.365.590.770.500', 'G05.558.805.500'], ['D12.776.260'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['G05.365.590.762.320', 'G05.558.800.320'], ['G05.380'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.... | ['Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The role of the Brr5/Ysh1 C-terminal domain and its homolog Syc1 in mRNA 3'-end processing in Saccharomyces cerevisiae. | The cleavage/polyadenylation factor (CPF) of Saccharomyces cerevisiae is thought to provide the catalytic activities of the mRNA 3'-end processing machinery, which include endonucleolytic cleavage at the poly(A) site, followed by synthesis of an adenosine polymer onto the new 3'-end by the CPF subunit Pap1. Because of ... | ['Amino Acid Sequence', 'Gene Deletion', 'Genes, Fungal', 'Molecular Sequence Data', 'Mutagenesis', 'Pancreatitis-Associated Proteins', 'Protein Structure, Tertiary', 'RNA Processing, Post-Transcriptional', 'RNA, Fungal', 'RNA, Messenger', 'Saccharomyces cerevisiae', 'Saccharomyces cerevisiae Proteins', 'mRNA Cleavage ... | 16,431,986 | [['G02.111.570.060', 'L01.453.245.667.060'], ['G05.365.590.762.320', 'G05.558.800.320'], ['G05.360.340.024.340.364.500', 'G05.360.340.358.024.500', 'G05.360.340.358.365.500'], ['L01.453.245.667'], ['G05.558'], ['D12.776.503.280.578', 'D23.050.285.733', 'D23.101.140.780'], ['G02.111.570.820.709.610'], ['G02.111.760', 'G... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Apparatus and method for investigation of energy consumption of microwave assisted drying systems. | Convective, hot air drying by itself is relatively efficient for removing water from the surface environment of agricultural seed products. However, moving internal moisture to the surface needs rather a long time, as a rule. The major research aim of the authors was to decrease the processing time and processing costs... | ['Air', 'Desiccation', 'Electric Power Supplies', 'Microwaves', 'Temperature'] | 19,895,084 | [['G16.500.275.063.150', 'N06.230.300.100.150'], ['E05.196.335', 'G02.176'], ['E07.305.124'], ['G01.358.500.505.810.500', 'G01.750.250.810.500', 'G01.750.770.721.500'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.150.450', 'N06.230.300.100.725.710']] | ['Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Novel VIM metallo-beta-lactamase variant, VIM-24, from a Klebsiella pneumoniae isolate from Colombia. | We report the emergence of a novel VIM variant (VIM-24) in a Klebsiella pneumoniae isolate in Colombia. The isolate displays MICs for carbapenems below the resistance breakpoints, posing a real challenge for its detection. The blaVIM-24 gene was located within a class 1 integron carried on a large plasmid. Further stud... | ['Anti-Bacterial Agents', 'Colombia', 'Drug Resistance, Multiple, Bacterial', 'Integrons', 'Klebsiella pneumoniae', 'Microbial Sensitivity Tests', 'Plasmids', 'beta-Lactamases'] | 21,282,438 | [['D27.505.954.122.085'], ['Z01.107.757.284'], ['G06.099.225.812', 'G06.225.347.812', 'G07.690.773.984.269.347.812', 'G07.690.773.984.300.500'], ['G02.111.570.080.708.330.200.500'], ['B03.440.450.425.425.600', 'B03.660.250.150.400.590'], ['E01.370.225.875.595', 'E05.200.875.595', 'E05.337.550.400'], ['G05.360.600'], ['... | ['Chemicals and Drugs [D]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
[Helicobacter pylori and Meckel's diverticulum]. | One quarter of Meckel's diverticula are covered by ectopic gastric mucosa and many may present histological inflammatory changes. Helicobacter pylori grows preferentially on an acid ground but has been found in different parts of the gastrointestinal tract. A prior hypothesis of a pathogenic role for this bacterium in ... | ['Adult', 'Choristoma', 'Female', 'Gastric Mucosa', 'Helicobacter Infections', 'Helicobacter pylori', 'Humans', 'Male', 'Meckel Diverticulum'] | 10,994,064 | [['M01.060.116'], ['C23.300.250'], ['A03.556.875.875.440', 'A10.615.550.291'], ['C01.150.252.400.466'], ['B03.440.500.550', 'B03.660.150.235.500.250.550'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A03.556.124.684.249.612', 'A03.556.249.124.612', 'C06.198.859', 'C06.405.205.282.750.750', 'C16.131.314.556', 'C2... | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Plasma glucagon, glucose, and free fatty acid concentrations and secretion during prolonged hypothermia in rats. | Impairment of metabolic substrate mobilization and utilization may be a factor limiting survival in hypothermia. Using a newly developed technique for maintaining stable low body temperature (Tb), substrate profiles and their regulation by glucagon were examined in hypothermic rats (Tb 19 +/- 0.3 degrees C) over 20 h. ... | ['Animals', 'Blood Glucose', 'Chronic Disease', 'Fatty Acids, Nonesterified', 'Glucagon', 'Hypothermia', 'Male', 'Osmolar Concentration', 'Rats', 'Rats, Inbred Strains'] | 2,000,996 | [['B01.050'], ['D09.947.875.359.448.500'], ['C23.550.291.500'], ['D10.251.310'], ['D06.472.699.587.730.500', 'D12.644.548.586.730.500'], ['C23.888.119.565'], ['G02.640'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760', 'B01.050.150.900.649.313.992.635.505.700.400']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vanadate-activated calcium influx in A431 cells is dependent on the plasma membrane potential. | Vanadate can activate the uptake of Ca in A431 epidermal carcinoma cells by two- to fivefold with no detectable lag period. Preincubation with epidermal growth factor (EGF) to down-regulate the EGF receptor prevents subsequent stimulation by EGF but not that by vanadate. Ca uptake is sodium-independent and is not activ... | ['Calcium', 'Carcinoma, Squamous Cell', 'Cell Line', 'Cell Membrane', 'Epidermal Growth Factor', 'ErbB Receptors', 'Humans', 'Kinetics', 'Membrane Potentials', 'Vanadates', 'Vanadium'] | 3,496,344 | [['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['A11.251.210'], ['A11.284.149'], ['D06.472.317.350', 'D12.644.276.382.500', 'D12.776.467.382.500', 'D23.529.382.500'], ['D08.811.913.696.620.682.725.400.009', 'D12.776.543.750.630.009', 'D12.776.543.750.750.400.074'... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Preparation and propagation of amyloid-enhancing factor. | Amyloid-enhancing factor (AEF) is a biological "activity" that is defined in the context of inflammation-associated amyloidogenesis (AA). When administered intravenously to mice followed by an inflammatory stimulus, such primed mice deposit substantial AA amyloid in spleen within 36-48 h. Since experimental induction o... | ['Amyloid', 'Animals', 'Female', 'Glycoproteins', 'Mice', 'Spleen'] | 15,980,607 | [['D05.500.049', 'D12.776.049'], ['B01.050'], ['D09.400.430', 'D12.776.395'], ['B01.050.150.900.649.313.992.635.505.500'], ['A10.549.700', 'A15.382.520.604.700']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
GC-clamp primer batches yield 16S rRNA gene amplicon pools with variable GC clamps, affecting denaturing gradient gel electrophoresis profiles. | Fingerprinting methods such as denaturing gradient gel electrophoresis (DGGE) of 16S rRNA gene pools have become a popular tool for comparisons between microbial communities. The GC-clamp portion of primers for DGGE amplicon preparation provides a key component in resolving fragments of similar size but different seque... | ['Bacteria', 'Base Sequence', 'DNA Primers', 'Denaturing Gradient Gel Electrophoresis', 'Molecular Sequence Data', 'RNA, Ribosomal, 16S', 'Soil Microbiology'] | 20,831,594 | [['B03'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['E05.196.401.402.117', 'E05.301.300.319.201'], ['L01.453.245.667'], ['D13.444.735.686.670'], ['H01.158.273.540.274.555', 'N06.850.425.300']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Combination therapy of advanced head and neck cancer: induction of remissions with diamminedichloroplatinum (II), bleomycin and radiation therapy. | Patients with unresectable, previously untreated head and neck cancer were given cis-diamminedichloroplatinum (II) (DDP), 3 mg/kg, with mannitol diuresis (day 1), followed by a continuous infusion of bleomycin, 0.25 mg/kg/day, days 3 through 10, after an initial loading dose of 0.25 mg/kg by rapid IV injection on day 3... | ['Adult', 'Aged', 'Bleomycin', 'Bone Marrow', 'Carcinoma, Squamous Cell', 'Cisplatin', 'Drug Therapy, Combination', 'Female', 'Head and Neck Neoplasms', 'Humans', 'Kidney', 'Male', 'Middle Aged', 'Mucous Membrane', 'Radiotherapy, High-Energy', 'Remission, Spontaneous', 'Time Factors'] | 75,760 | [['M01.060.116'], ['M01.060.116.100'], ['D09.400.420.110', 'D12.644.233.110'], ['A15.382.216'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['D01.210.375', 'D01.625.125', 'D01.710.100'], ['E02.319.310'], ['C04.588.443'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A05.810.453'], ['M01.060.116.630'], ['A10.61... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Reliability and validity of the Assessment of Quality of Life in Asthma Patients (QLQ-Asthma) in a sample of adult asthmatic patients in Turkey. | AIMS AND OBJECTIVES: The aims of this study were to translate the 20-item Questionnaire for the Assessment of Quality of Life in Asthma Patients (QLQ-Asthma) into Turkish and to assess the reliability and validity of the Turkish version of the Assessment of Quality of Life in Asthma Patients among Turkish adult asthmat... | ['Adult', 'Asthma', 'Female', 'Humans', 'Male', 'Psychometrics', 'Quality of Life', 'Surveys and Questionnaires', 'Turkey'] | 21,059,126 | [['M01.060.116'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F04.711.780'], ['I01.800', 'K01.752.400.750', 'N06.850.505.400.425.837'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980'], ['Z01.252.245.500.850']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Synthesis and docking studies of some novel quinoline derivatives bearing a sulfonamide moiety as possible anticancer agents. | Sulfonamides posses many types of biological activities and have recently been reported to show substantial antitumor activity in vitro and/or in vivo. There is a variety of mechanisms for the anticancer activity of the sulfonamide compounds and the most prominent of these is the inhibition of carbonic anhydrase isozym... | ['Antineoplastic Agents', 'Breast Neoplasms', 'Carbonic Anhydrases', 'Cell Line, Tumor', 'Crystallography, X-Ray', 'Drug Screening Assays, Antitumor', 'Female', 'Humans', 'Indicators and Reagents', 'Magnetic Resonance Spectroscopy', 'Models, Molecular', 'Protein Binding', 'Quinolines', 'Spectrophotometry, Infrared', 'S... | 20,422,946 | [['D27.505.954.248'], ['C04.588.180', 'C17.800.090.500'], ['D08.811.520.241.300.150'], ['A11.251.210.190', 'A11.251.860.180'], ['E05.196.309.742.225'], ['E01.370.225.500.388', 'E05.200.500.388', 'E05.242.417', 'E05.337.550.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.720.470.410'], ['E05.196.867.519'],... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Neutralization of interleukin-17 attenuates high fat diet-induced non-alcoholic fatty liver disease in mice. | Non-alcoholic fatty liver disease (NAFLD) is hepatic manifestation of a metabolic syndrome and includes a spectrum of hepatic steatosis, steatohepatitis, and fibrosis. Interleukin-17 (IL-17) has been reported to play a critical role in inflammatory progression of some liver diseases. The present study was designed to i... | ['Animals', 'Antibodies, Monoclonal', 'Antigens, Differentiation', 'Blotting, Western', 'Diet, High-Fat', 'Disease Models, Animal', 'Fatty Liver', 'Gene Expression', 'Humans', 'Inflammation Mediators', 'Interleukin-17', 'Interleukin-6', 'Liver', 'Macrophages', 'Male', 'Mice', 'Mice, Inbred C57BL', 'NF-kappa B', 'Non-al... | 23,786,840 | [['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D23.050.301.264', 'D23.101.100'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['G07.203.650.240.267'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The analgesic and anticonvulsant effects of piperine in mice. | Piperine, is the major active principal of black pepper. In traditional medicine, black pepper has been used as an analgesic, anti-inflammatory agent and in the treatment of epilepsy. This study was conducted to evaluate the in vivo analgesic and anticonvulsant effects of piperine in mice. The analgesic and anticonvuls... | ['Acetic Acid', 'Alkaloids', 'Analgesics', 'Animals', 'Anticonvulsants', 'Benzodioxoles', 'Hot Temperature', 'Male', 'Mice', 'Naloxone', 'Narcotic Antagonists', 'Pain', 'Pentylenetetrazole', 'Picrotoxin', 'Piper nigrum', 'Piperidines', 'Polyunsaturated Alkamides', 'Seizures'] | 24,388,894 | [['D02.241.081.018.165', 'D10.251.400.045.500'], ['D03.132'], ['D27.505.696.663.850.014', 'D27.505.954.427.040'], ['B01.050'], ['D27.505.954.427.080'], ['D03.383.246.118', 'D03.633.100.115'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.775.710.380', 'N06.230.300.100.725.232', 'N06.230.300.100.725.71... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
The behavior of hair from different countries. | The properties of curly hair from different countries were assessed using geometrical measurements from a laser scanning micrometer and a new hair shape classification method. In addition, tensile tests, 2-D gel electrophoresis, and differential scanning calorimetry (DSC) were performed. Results concluded that hair cha... | ['African Continental Ancestry Group', 'Amino Acids', 'Calorimetry, Differential Scanning', 'Electrophoresis, Gel, Two-Dimensional', 'Hair', 'Humans', 'Regression Analysis', 'Tensile Strength'] | 19,450,412 | [['M01.686.508.100'], ['D12.125'], ['E05.196.131.310', 'E05.196.370.310'], ['E05.196.401.250', 'E05.301.300.230'], ['A17.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.750', 'N05.715.360.750.695', 'N06.850.520.830.750'], ['G01.374.850']] | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Characterization of the gene for the mouse prostaglandin E receptor subtype EP2: tissue-specific initiation of transcription in the macrophage and the uterus. | Genomic DNA clones for the mouse prostaglandin (PG) E receptor subtype EP2 were isolated and characterized. The mouse EP2 gene is composed of 2 exons and 1 intron, and spans 16 kb. The intron which is approx. 12 kb in length is located at the end of the sixth transmembrane domain, as with other prostanoid receptor gene... | ['Amino Acid Sequence', 'Animals', 'Base Sequence', 'DNA, Complementary', 'Exons', 'Female', 'Genomic Library', 'Introns', 'Macrophages', 'Mice', 'Molecular Sequence Data', 'Organ Specificity', 'Receptors, Prostaglandin E', 'Recombinant Proteins', 'Restriction Mapping', 'Transcription, Genetic', 'Uterus'] | 9,494,075 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D13.444.308.497.220', 'D13.444.600.223.500', 'D27.720.470.530.600.223.260'], ['G05.360.340.024.340.137.232'], ['G05.360.325.425', 'G05.360.340.425'], ['G05.360.340.024.220.400', 'G05.360.340.024.340.13... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Maintaining lasting improvements: one-year follow-up of children with severe chronic pain undergoing multimodal inpatient treatment. | OBJECTIVE: To investigate the long-term effectiveness of a 3-week multimodal inpatient program for children and adolescents with chronic pain.METHODS: 167 adolescents were evaluated at pretreatment baseline, 3-, and 12-month follow-up. Long-term effectiveness was investigated for pain-related variables (pain-related di... | ['Adaptation, Psychological', 'Adolescent', 'Child', 'Chronic Pain', 'Combined Modality Therapy', 'Disability Evaluation', 'Female', 'Follow-Up Studies', 'Humans', 'Inpatients', 'Male', 'Pain Management', 'Pain Measurement', 'Stress, Psychological', 'Treatment Outcome'] | 23,161,126 | [['F01.058'], ['M01.060.057'], ['M01.060.406'], ['C23.888.592.612.274'], ['E02.186'], ['E01.370.400'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.643.470'], ['E02.745', 'N04.590.607.500'], ['E01.370.600.550.324'], ['F... | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Antibiotic-loaded calcium carbonate/calcium sulfate granules as co-adjuvant for bone grafting. | In this study HERAFILL(®) granules containing gentamicin was evaluated as a bone void filling material once mixed with allograft bone grafts. The efficacy of the bone grafts mixed with HERAFILL(®) was measured by drug release tests and bacterial susceptibility using Bacillus subtilis, Staphylococcus epidermidis and Sta... | ['Anti-Bacterial Agents', 'Arthroplasty, Replacement, Hip', 'Bacillus subtilis', 'Biocompatible Materials', 'Biological Assay', 'Bone Substitutes', 'Bone Transplantation', 'Calcium Carbonate', 'Calcium Sulfate', 'Drug Delivery Systems', 'Femur', 'Gentamicins', 'Humans', 'Microbial Sensitivity Tests', 'Orthopedics', 'Pa... | 25,578,698 | [['D27.505.954.122.085'], ['E04.555.110.110.110', 'E04.650.110.110', 'E04.680.101.110.110'], ['B03.300.390.400.158.218.725', 'B03.353.500.100.218.725', 'B03.510.100.100.218.725', 'B03.510.415.400.158.218.725', 'B03.510.460.410.158.218.725'], ['D25.130', 'D27.720.102.130', 'J01.637.051.130'], ['E05.091'], ['D25.130.325'... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Confirmation of okadaic acid, dinophysistoxin-1 and dinophysistoxin-2 in shellfish as their anthrylmethyl derivatives using UV radiation. | A rapid and simple method for confirmation of the diarrhetic shellfish poisons (DSP): okadaic acid (OA), dinophysistoxin-1 (DTX-1) and dinophysistoxin-2 (DTX-2) using fluorescence detection following derivatization with 9-chloromethylanthracene, has been established as an alternate to LC/MS. Exposure of the anthrylmeth... | ['Animals', 'Anthracenes', 'Bivalvia', 'Chromatography, Liquid', 'Dinoflagellida', 'Marine Toxins', 'Mass Spectrometry', 'Okadaic Acid', 'Pyrans', 'Sensitivity and Specificity', 'Spectrometry, Fluorescence', 'Ultraviolet Rays'] | 16,008,053 | [['B01.050'], ['D02.455.426.559.847.117', 'D04.615.117'], ['B01.050.500.644.080'], ['E05.196.181.400'], ['B01.043.214'], ['D23.946.580'], ['E05.196.566'], ['D02.355.291.705', 'D23.946.580.710'], ['D03.383.663'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700', 'N05.715.360.750.725', 'N06.850.520... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Double labeling and in vitro versus in vivo incorporation of bromodeoxyuridine in patients with acute nonlymphocytic leukemia. | A monoclonal antibody against bromodeoxyuridine (BrdUrd) was produced, and a rapid slide technique (RPMB technique) was developed for the estimation of S-phase cells in a population using this antibody. Bone marrow cells from patients with acute nonlymphocytic leukemia (ANLL) were studied by both the RPMB technique and... | ['Automation', 'Autoradiography', 'Bone Marrow Cells', 'Bromodeoxyuridine', 'Cell Cycle', 'Cytarabine', 'DNA, Neoplasm', 'Fluorescent Antibody Technique', 'Humans', 'Immunoenzyme Techniques', 'Leukemia', 'Thymidine'] | 3,905,302 | [['J01.897.104'], ['E01.370.225.750.132', 'E05.200.750.132', 'E05.799.256'], ['A11.148', 'A15.378.316'], ['D03.383.742.680.852.300.150', 'D13.570.230.430.196', 'D13.570.685.852.300.150'], ['G04.144'], ['D03.383.742.680.245.453', 'D13.570.065.300', 'D13.570.685.245.453'], ['D13.444.308.425'], ['E01.370.225.500.607.512.2... | ['Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Pyloric size in normal infants and in infants suspected of having hypertrophic pyloric stenosis. | Pyloric muscle thickness (PMT) and pyloric diameter (PD) were determined by sonography in 92 healthy infants aged 8 to 70 days. PMT and PD measured median 2.0 mm and 10.0 mm. There was a significant correlation between the pyloric dimensions and the infant's age, p < 0.02 and p < 0.00001 for PMT and PD, respectively. I... | ['Age Factors', 'Body Height', 'Body Weight', 'Case-Control Studies', 'Female', 'Follow-Up Studies', 'Humans', 'Hypertrophy', 'Infant', 'Infant, Newborn', 'Male', 'Muscle, Smooth', 'Pyloric Stenosis', 'Pylorus', 'Ultrasonography'] | 7,742,118 | [['N05.715.350.075', 'N06.850.490.250'], ['E01.370.600.115.100.160.100', 'E05.041.124.160.500', 'G07.100.100.160.100', 'G07.345.249.314.100'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.... | ['Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
White-matter integrity on DTI and the pathologic staging of Alzheimer's disease. | Pattern of diffusion tensor MRI (DTI) alterations were investigated in pathologically-staged Alzheimer's disease (AD) patients (n = 46). Patients with antemortem DTI studies and a range of AD pathology at autopsy were included. Patients with a high neurofibrillary tangle (NFT) stage (Braak IV-VI) had significantly elev... | ['Aged', 'Aged, 80 and over', 'Aging', 'Alzheimer Disease', 'Diffusion Magnetic Resonance Imaging', 'Diffusion Tensor Imaging', 'Female', 'Humans', 'Male', 'Middle Aged', 'Severity of Illness Index', 'White Matter'] | 28,552,181 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['G07.345.124'], ['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['E01.370.350.825.500.150'], ['E01.370.350.578.750', 'E01.370.350.825.500.150.500', 'E01.370.376.537.500', 'E05.629.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of schizophrenia, part 2: long-term treatment of schizophrenia. | These guidelines for the biological treatment of schizophrenia were developed by an international Task Force of the World Federation of Societies of Biological Psychiatry (WFSBP). The goal during the development of these guidelines was to review systematically all available evidence pertaining to the treatment of schiz... | ['Antipsychotic Agents', 'Biological Psychiatry', 'Evidence-Based Medicine', 'Guidelines as Topic', 'Humans', 'International Cooperation', 'Schizophrenia', 'Societies, Medical', 'Time Factors'] | 16,509,050 | [['D27.505.696.277.950.040', 'D27.505.954.427.210.950.040', 'D27.505.954.427.700.872.331'], ['F04.096.544.090', 'H02.403.690.100'], ['H02.249.750', 'H02.403.200.400'], ['N04.761.700.350', 'N05.700.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I01.615.500'], ['F03.700.750'], ['N03.540.828.589'], ['G01.910.85... | ['Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 |
The boundaries for joint angles of isocomfort for sitting and standing males based on perceived comfort of static joint postures. | This study presents data for the joint angles of isocomfort (JAI) in sitting and standing males based on perceived comfort ratings for static joint postures maintained for 60 s. The JAI value was defined as a boundary indicating joint deviation (an angle) from neutral posture, within which the perceived comfort for dif... | ['Adult', 'Ergonomics', 'Humans', 'Joints', 'Male', 'Posture', 'Range of Motion, Articular'] | 11,373,024 | [['M01.060.116'], ['F02.784.412', 'J01.293.556'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.583'], ['G11.427.695'], ['E01.370.600.700', 'G11.427.760']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 |
Estimation of the incidence and factors predictive of corneal scarring in the Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study. | PURPOSE: The multicenter Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study is a prospective, observational study of 1209 keratoconus patients. We report methods to define incident corneal scarring and baseline factors predictive of incident corneal scarring in nonsurgical eyes of CLEK Study keratoconus ... | ['Adult', 'Age Factors', 'Cicatrix', 'Contact Lenses', 'Corneal Opacity', 'Female', 'Humans', 'Incidence', 'Keratoconus', 'Longitudinal Studies', 'Male', 'Odds Ratio', 'Prospective Studies', 'Risk Factors', 'United States'] | 16,331,035 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['A10.165.450.300', 'C23.550.355.274', 'G16.762.891.249'], ['E07.632.500.276'], ['C11.204.299'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.985.525.375'], ['... | ['Named Groups [M]', 'Health Care [N]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Lichen scrofulosorum: a prospective study of 39 patients. | BACKGROUND: Lichen scrofulosorum is considered a rare form of cutaneous tuberculosis. Current information is based on case reports and case series with a small number of patients.METHODS: Thirty-nine patients with Lichen scrofulosorum were followed during the period January 1996 to December 2002. Clinical details (age,... | ['Adolescent', 'Adult', 'Antitubercular Agents', 'BCG Vaccine', 'Brain Diseases', 'Child', 'Child, Preschool', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Prospective Studies', 'Tuberculosis, Cutaneous', 'Tuberculosis, Lymph Node', 'Tuberculosis, Pulmonary', 'Vaccination'] | 15,941,438 | [['M01.060.057'], ['M01.060.116'], ['D27.505.954.122.085.255'], ['D20.215.894.135.825.100'], ['C10.228.140'], ['M01.060.406'], ['M01.060.406.448'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.500.750.625', 'N05... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Nutritional impact of highly pathogenic avian influenza in Kenya. | BACKGROUND: Outbreaks of highly pathogenic avian influenza (HPAI) (virus type H5N1) have led to extensive bird culling and other control measures throughout the world, with implications especially for the livelihoods of the poor. There is limited empirical evidence for the impact of HPAI on poultry consumption and nutr... | ['Animals', 'Body Weight', 'Child, Preschool', 'Educational Status', 'Female', 'Food Preferences', 'Humans', 'Infant', 'Influenza A Virus, H5N1 Subtype', 'Influenza in Birds', 'Kenya', 'Male', 'Nutritional Status', 'Poultry', 'Sex Distribution', 'Socioeconomic Factors', 'Thinness'] | 24,167,910 | [['B01.050'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['M01.060.406.448'], ['N01.824.196'], ['F01.145.407.516', 'G07.203.650.353.516'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['B04.820.480.968.405.400.500'], ['C01.92... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Named Groups [M]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]', 'Technology, Industry, and Agriculture [J]', 'Anthropology, Education, Sociology, and Soci... | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
Changes in Oxidative Stress and Inflammatory Biomarkers in Fragile Adults over Fifty Years of Age and in Elderly People Exclusively Fed Enteral Nutrition. | We aim to evaluate whether exclusive feeding of an enteral formula enriched with n-3 long chain polyunsaturated fatty acids (n-3 LC-PUFA) affects oxidative stress and the antioxidant defence system and may improve the levels of some relevant inflammatory, and cardiovascular biomarkers in frail adults over fifty years o... | ['Aged', 'Aged, 80 and over', 'Biomarkers', 'Diet', 'Docosahexaenoic Acids', 'Eicosapentaenoic Acid', 'Enteral Nutrition', 'Erythrocytes', 'Fatty Acids', 'Hemoglobins', 'Humans', 'Lipids', 'Matrix Metalloproteinase 9', 'Middle Aged', 'Oxidative Stress', 'Plasminogen Activator Inhibitor 1', 'Spectrophotometry', 'Treatme... | 26,697,137 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['D23.101'], ['G07.203.650.240'], ['D10.212.302.380.410.210', 'D10.251.355.337.250', 'D10.627.430.450.375'], ['D10.212.302.380.410.385', 'D10.251.355.255.200', 'D10.251.355.337.290', 'D10.627.430.450.390'], ['E02.421.360', 'E02.642.500.360'], ['A11.118.290', 'A11.443.240',... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Insulin-like growth factor-I and its binding protein-3 in serum: are they good screening properties for the diagnosis of growth hormone deficiency? | Serum insulin-like growth factor-I and insulin-like growth factor binding protein-3 are simply-determined screening analytes if growth hormone deficiency is suspected. The analysis of growth hormone secretion using standardised stimulation tests and secretion profiles is complicated and expensive in comparison. In retr... | ['Adolescent', 'Body Height', 'Child', 'Child, Preschool', 'Female', 'Genetic Variation', 'Growth Disorders', 'Human Growth Hormone', 'Humans', 'Insulin-Like Growth Factor Binding Protein 3', 'Insulin-Like Growth Factor I', 'Male', 'Neurosecretory Systems', 'Predictive Value of Tests', 'Retrospective Studies'] | 9,189,743 | [['M01.060.057'], ['E01.370.600.115.100.160.100', 'E05.041.124.160.500', 'G07.100.100.160.100', 'G07.345.249.314.100'], ['M01.060.406'], ['M01.060.406.448'], ['G05.365'], ['C23.550.393'], ['D06.472.699.631.525.425.875', 'D12.644.548.691.525.425.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.157.420.2... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Zinc-á-2-glycoprotein: a candidate biomarker for colon cancer diagnosis in Chinese population. | Zinc-á-2-glycoprotein (AZGP1) is a 41-kDa secreted glycoprotein, which has been detected in several malignancies. The diagnostic value of AZGP1 in serum of prostate and breast cancer patients has been reported. Analyzing "The Cancer Genome Atlas" data, we found that in colon cancer AZGP1 gene expression was upregulated... | ['Adipokines', 'Adult', 'Aged', 'Aged, 80 and over', 'Area Under Curve', 'Asian Continental Ancestry Group', 'Biomarkers, Tumor', 'CA-19-9 Antigen', 'Carcinoembryonic Antigen', 'Carrier Proteins', 'China', 'Colonic Neoplasms', 'Enzyme-Linked Immunosorbent Assay', 'Female', 'Glycoproteins', 'Humans', 'Male', 'Middle Age... | 25,561,225 | [['D06.472.699.042', 'D12.644.276.024', 'D12.644.548.011', 'D12.776.467.024', 'D23.529.024'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.318.740.200', 'G03.787.101', 'G07.690.725.064', 'N06.850.520.830.200'], ['M01.686.508.200'], ['D23.101.140'], ['D23.050.285.050.119', 'D23.050.301.290.544.11... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Geographicals [Z]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
[Public health, prevention and federalism: insights from the implementation of the federal law on health insurance]. | OBJECTIVES: In 1996, the new Swiss law on health care insurance (KVG) introduced the coverage of certain preventive measures. This provided an opportunity to include research-based public health issues in federal health policy. The present article examines the problems with which the realization of those goals in a Fed... | ['Adult', 'Child', 'Female', 'Health Plan Implementation', 'Humans', 'Insurance Coverage', 'Mammography', 'Mass Screening', 'National Health Programs', 'Organizational Objectives', 'Policy Making', 'Politics', 'Preventive Health Services', 'Switzerland', 'Vaccination'] | 15,224,543 | [['M01.060.116'], ['M01.060.406'], ['N03.349.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.219.521.576.265'], ['E01.370.350.700.500'], ['E01.370.500', 'E05.318.308.980.438.580', 'N02.421.726.233.443', 'N05.715.360.300.800.438.500', 'N06.850.520.308.980.438.580', 'N06.850.780.500'], ['N03.349.550'], ['N0... | ['Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Medical practitioners and competition law in Australia and New Zealand. | There is a lack of awareness among Australian and New Zealand medical practitioners about how competition law applies to them. In this article, basic legal issues relating to interaction between medical practitioners (which all medical practitioners should be aware of) are discussed. The New Zealand Ophthalmologists Ca... | ['Accreditation', 'Australia', 'Collective Bargaining', 'Economic Competition', 'Ethics, Professional', 'Guidelines as Topic', 'Humans', 'Negotiating', 'New Zealand', 'Practice Management, Medical', 'Professional Autonomy'] | 15,915,187 | [['N03.706.110.070', 'N05.700.200.100'], ['Z01.639.100', 'Z01.678.100.373'], ['N03.540.571.356', 'N04.452.677.356'], ['N03.219.188'], ['K01.752.566.479.171', 'N05.350.340'], ['N04.761.700.350', 'N05.700.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.209.520', 'F01.829.401.520', 'F02.463.785.373.520',... | ['Health Care [N]', 'Geographicals [Z]', 'Humanities [K]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 |
Simplifying the synthesis of SIgA: combination of dIgA and rhSC using affinity chromatography. | The mucosal epithelia together with adaptive immune responses, such as local production and secretion of dimeric and polymeric immunoglobulin A (IgA), are a crucial part of the first line of defense against invading pathogens. IgA is primarily secreted as SIgA and plays multiple roles in mucosal defense. The study of S... | ['Animals', 'Antibodies, Neutralizing', 'CHO Cells', 'Chromatography, Affinity', 'Cricetinae', 'Cricetulus', 'HIV Envelope Protein gp120', 'HIV-1', 'Humans', 'Immunoglobulin A, Secretory', 'Protein Binding', 'Protein Engineering', 'Recombinant Proteins'] | 23,811,333 | [['B01.050'], ['D12.776.124.486.485.114.244', 'D12.776.124.790.651.114.244', 'D12.776.377.715.548.114.244'], ['A11.251.210.200', 'A11.436.155'], ['E05.196.181.400.170'], ['B01.050.150.900.649.313.992.635.075.250'], ['B01.050.150.900.649.313.992.635.075.250.250'], ['D12.776.964.775.325.164.249', 'D12.776.964.775.562.500... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Metabolic cage isolation reduces antipyrine clearance in rats. | Rats are commonly isolated individually in cages during pharmacokinetic studies. However, isolation-induced changes in drug disposition are not commonly examined. Antipyrine is a marker of hepatic oxidative function and total body water. The purpose of the study was to investigate the effect of individual housing on an... | ['Analysis of Variance', 'Animals', 'Antipyrine', 'Body Water', 'Body Weight', 'Computer Simulation', 'Dose-Response Relationship, Drug', 'Electrophoresis', 'Housing, Animal', 'Injections, Intravenous', 'Liver', 'Male', 'Models, Biological', 'Oxidation-Reduction', 'Rats', 'Rats, Sprague-Dawley'] | 7,996,387 | [['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['B01.050'], ['D03.383.129.539.850.088'], ['A12.207.200'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['L01.224.160'], ['G07.690.773.875', 'G07.690.936.500'], ['E05.196.401', 'E0... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 |
Wound area measurement with 3D transformation and smartphone images. | BACKGROUND: Quantitative areas is of great measurement of wound significance in clinical trials, wound pathological analysis, and daily patient care. 2D methods cannot solve the problems caused by human body curvatures and different camera shooting angles. Our objective is to simply collect wound areas, accurately meas... | ['Algorithms', 'Humans', 'Imaging, Three-Dimensional', 'Smartphone', 'Wounds and Injuries'] | 31,852,433 | [['G17.035', 'L01.224.050'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.400', 'L01.224.308.410'], ['L01.178.847.698.300.250', 'L01.224.230.260.550.500.750'], ['C26']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Increased sensitivity to the inhibitory effect of excess iodide on thyroid function in patients with beta-thalassemia major and iron overload and the subsequent development of hypothyroidism. | OBJECTIVE: Patients with beta-thalassemia frequently develop primary hypothyroidism and other endocrine disorders due to iron overload. We studied whether administration of excess iodide to patients with apparently normal thyroid function could uncover an underlying thyroid disease.DESIGN AND METHODS: Twenty-five patie... | ['Adolescent', 'Adult', 'Child', 'Child, Preschool', 'Female', 'Ferritins', 'Follow-Up Studies', 'Humans', 'Hypothyroidism', 'Iodides', 'Iron Overload', 'Liver Function Tests', 'Male', 'Thyroid Function Tests', 'Thyroid Gland', 'Thyroid Hormones', 'Thyrotropin', 'Ultrasonography', 'beta-Thalassemia'] | 11,022,172 | [['M01.060.057'], ['M01.060.116'], ['M01.060.406'], ['M01.060.406.448'], ['D12.776.157.427.249', 'D12.776.556.579.249'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C19.874.482'], ['D01.248.497.158.490', 'D01.475.410'], ['... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Calcifying odontogenic epithelial tumor--a clinical and morphological study]. | The authors describe the clinical and morphological study of a calcifying epithelial odontogenic tumor, localized in the right mandibular angle and in the ascending branch, in a 29-years-old male patient. It is emphasized that this benign and non invasive tumor presents poor clinical manifestations, a typical radiologi... | ['Adult', 'Humans', 'Male', 'Mandible', 'Mandibular Neoplasms', 'Odontogenic Tumors', 'Radiography, Panoramic'] | 7,492,893 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.232.781.324.502.632', 'A14.521.632'], ['C04.588.149.721.450.583', 'C05.116.231.754.450.583', 'C05.500.499.583', 'C05.500.607.442', 'C07.320.515.583', 'C07.320.610.583'], ['C04.557.695'], ['E01.370.350.700.720.750', 'E06.342.764.750']] | ['Named Groups [M]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Recombinant Escherichia coli GMP reductase: kinetic, catalytic and chemical mechanisms, and thermodynamics of enzyme-ligand binary complex formation. | Guanosine monophosphate (GMP) reductase catalyzes the reductive deamination of GMP to inosine monophosphate (IMP). GMP reductase plays an important role in the conversion of nucleoside and nucleotide derivatives of guanine to adenine nucleotides. In addition, as a member of the purine salvage pathway, it also participa... | ['Amino Acid Sequence', 'Catalysis', 'Cloning, Molecular', 'Escherichia coli', 'GMP Reductase', 'Gene Expression Regulation, Bacterial', 'Kinetics', 'Ligands', 'Models, Molecular', 'Molecular Sequence Data', 'Protein Binding', 'Recombinant Proteins', 'Sequence Alignment', 'Thermodynamics'] | 21,298,178 | [['G02.111.570.060', 'L01.453.245.667.060'], ['G02.130'], ['E05.393.220'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D08.811.682.655.249'], ['G05.308.300'], ['G01.374.661', 'G02.111.490'], ['D27.720.470.480'], ['E05.599.595'], ['L01.453.245.667'], ['G02.111.679', 'G03.808'], ['D12.776.828'], ['E05.393.7... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
TBrowse: an integrative genomics map of Mycobacterium tuberculosis. | Tuberculosis is one of the major infectious diseases causing morbidity and mortality in the developing world. Genome-wide experiments on Mycobacterium tuberculosis particularly H37Rv and many other strains has revealed a wealth of information on the pathogen. This has been complemented by computational methods for the ... | ['Computational Biology', 'Databases, Factual', 'Databases, Genetic', 'Genomics', 'Humans', 'Information Storage and Retrieval', 'Mycobacterium tuberculosis', 'Research', 'Tuberculosis', 'User-Computer Interface'] | 19,683,474 | [['H01.158.273.180', 'L01.313.124'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['L01.313.500.750.300.188.400.325', 'L01.470.750.750.325'], ['H01.158.273.180.350', 'H01.158.273.343.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.313.500.750.280', 'L01.470'], ['B03.510.024.962.500.702', 'B03.510.4... | ['Disciplines and Occupations [H]', 'Information Science [L]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Costs and Trends of Emergency Department Utilization Pre-ACA and Post-ACA: Evidence From a Rural Georgia Hospital. | BACKGROUND: A high volume of emergency department (ED) visits in the rural United States may be the result of barriers to accessing primary care. The Affordable Care Act (ACA) increased the number of insured, which may improve patient access to primary care and therefore reduce ED utilization. The objective of this stu... | ['Adult', 'Emergency Service, Hospital', 'Georgia', 'Hospitals, Rural', 'Humans', 'Patient Acceptance of Health Care', 'Patient Protection and Affordable Care Act', 'United States', 'Utilization Review'] | 30,994,524 | [['M01.060.116'], ['N02.278.216.500.968.336', 'N02.421.297.195', 'N04.452.442.452.422.336'], ['Z01.107.567.875.075.250', 'Z01.107.567.875.750.370'], ['N02.278.421.518'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.100.150.750.500', 'F01.145.488.887.500', 'N05.300.150.800.500'], ['N03.219.521.576.343.918', 'N... | ['Named Groups [M]', 'Health Care [N]', 'Geographicals [Z]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Seasonal variation in the incidence of gastroesophageal reflux disease. | BACKGROUND: To examine the seasonal variation in the incidence of gastroesophageal reflux disease (GERD) for different gender and age groups and its association with climatic parameters (ambient temperature, relative humidity, atmospheric pressure, rainfall, and hours of sunshine).METHODS: A total of 76,636 ambulatory ... | ['Adult', 'Aged', 'Climate', 'Female', 'Gastroesophageal Reflux', 'Humans', 'Male', 'Middle Aged', 'Regression Analysis', 'Seasons', 'Taiwan', 'Weather', 'Young Adult'] | 19,826,247 | [['M01.060.116'], ['M01.060.116.100'], ['G16.500.275.071', 'N06.230.300.100.250'], ['C06.405.117.119.500.484'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.740.750', 'N05.715.360.750.695', 'N06.850.520.830.750'], ['G01.910.645.661', 'G16.500.275.071.590', 'N06.230.300.100.250.525'], ... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Percutaneous thermal ablation of subcapsular hepatocellular carcinomas: influence of tumor-surface contact and protrusion on therapeutic efficacy and safety. | PURPOSE: To evaluate therapeutic efficacy and complication of percutaneous thermal ablation of subcapsular hepatocellular carcinomas (HCCs), and how these may be influenced by the degree of tumor to liver surface contact and tumor protrusion from liver surface.MATERIALS AND METHODS: Our retrospective study was approved... | ['Adult', 'Aged', 'Aged, 80 and over', 'Carcinoma, Hepatocellular', 'Catheter Ablation', 'Female', 'Humans', 'Hyperthermia, Induced', 'Liver Neoplasms', 'Male', 'Middle Aged', 'Neoplasm Seeding', 'Retrospective Studies', 'Treatment Outcome'] | 31,822,975 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['E02.808.750.500', 'E04.014.760.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.565'], ['C04.588.274.623', 'C06.301.623', 'C06.552.697'], ['M01.060.116... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Focusing resource allocation-wellbeing as a tool for prioritizing interventions for communities at risk. | OBJECTIVE: This study examined whether a wellbeing approach to resilience and adaptation would provide practical insights for prioritizing support to communities experiencing environmental and socio-economic stressors.METHODS: A cross-sectional survey, based on a purposive sample of 2,196 stakeholders (landholders, hob... | ['Adult', 'Aged', 'Australia', 'Cluster Analysis', 'Cross-Sectional Studies', 'Female', 'Humans', 'Longitudinal Studies', 'Male', 'Middle Aged', 'Personal Satisfaction', 'Residence Characteristics', 'Resilience, Psychological', 'Resource Allocation', 'Risk Factors', 'Self-Assessment', 'Social Environment', 'Social Supp... | 23,924,885 | [['M01.060.116'], ['M01.060.116.100'], ['Z01.639.100', 'Z01.678.100.373'], ['E05.318.740.250', 'N05.715.360.750.200', 'N06.850.520.830.250'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.500.750.500', 'N05.715.360.330.500.7... | ['Named Groups [M]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Expression of FACT in mammalian tissues suggests its role in maintaining of undifferentiated state of cells. | The Facilitates Chromatin Transcription (FACT) chromatin remodeling complex, comprised of two subunits, SSRP1 and SPT16, is involved in transcription, replication and DNA repair. We recently showed that curaxins, small molecules with anti-cancer activity, target FACT and kill tumor cells in a FACT-dependent manner. We ... | ['Adult', 'Animals', 'Cell Cycle Proteins', 'Cell Differentiation', 'Cell Proliferation', 'Cells, Cultured', 'Chromatin', 'DNA-Binding Proteins', 'Female', 'Fibrosarcoma', 'High Mobility Group Proteins', 'Humans', 'Ki-67 Antigen', 'Male', 'Mice', 'Myoblasts', 'Transcription Factors', 'Transcription, Genetic', 'Transcri... | 21,998,152 | [['M01.060.116'], ['B01.050'], ['D12.776.167'], ['G04.152'], ['G04.161.750', 'G07.345.249.410.750'], ['A11.251'], ['A11.284.430.106.279.345.190.160.180', 'D12.776.664.224', 'G05.360.160.180'], ['D12.776.260'], ['C04.557.450.565.590.350', 'C04.557.450.795.350'], ['D12.776.660.235.400', 'D12.776.664.235.400'], ['B01.050.... | ['Named Groups [M]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Total synthesis of amaminol A: establishment of the absolute stereochemistry. | The first synthetic route to amaminol A with use of an organocatalytic intramolecular Diels-Alder reaction is reported. The absolute stereochemistry is proven with a crystallographic image of a cyclic carbamate of amaminol A. | ['Amino Alcohols', 'Bridged Bicyclo Compounds', 'Carbamates', 'Crystallography, X-Ray', 'Models, Molecular', 'Molecular Structure', 'Stereoisomerism'] | 17,956,115 | [['D02.033.100', 'D02.092.063'], ['D02.455.426.100.080', 'D04.075.080'], ['D02.241.081.251'], ['E05.196.309.742.225'], ['E05.599.595'], ['G02.111.570', 'G02.466'], ['G02.607.445.682']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Expression of ribosomal phosphoprotein PO is induced by antitumor agents and increased in Mer- human tumor cell lines. | We initiated this study to determine whether three structurally related bifunctional alkylating agents could induce the expression of a presumptive human DNA repair gene. The gene chosen for this study is known to encode the ribosomal phosphoprotein PO, but ironically may also share functions related to DNA repair. We ... | ['Antineoplastic Agents', 'Blotting, Northern', 'Blotting, Southern', 'Cyclophosphamide', 'DNA Probes', 'DNA Repair', 'Electrophoresis, Agar Gel', 'Gene Expression', 'Humans', 'Mechlorethamine', 'Melphalan', 'Methyltransferases', 'O(6)-Methylguanine-DNA Methyltransferase', 'Phosphoproteins', 'Ribosomal Proteins', 'Tumo... | 1,740,017 | [['D27.505.954.248'], ['E05.196.401.095', 'E05.301.300.074', 'E05.601.100'], ['E05.196.401.114', 'E05.301.300.087', 'E05.601.150'], ['D02.455.526.728.650.730.243', 'D02.705.672.500.243'], ['D13.444.600.223', 'D27.505.259.750.600.223', 'D27.720.470.530.600.223'], ['G02.111.222', 'G05.219'], ['E05.196.401.153', 'E05.301.... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Iron Deficiency in the Absence of Anemia Impairs the Perception of Health-Related Quality of Life of Patients with Inflammatory Bowel Disease. | BACKGROUND: Anemia is a common complication of inflammatory bowel disease (IBD) and contributes to the deterioration of health-related quality of life (HRQOL). Iron deficiency (ID) is a prevalent underlying factor, present in up to 90% of patients. In the absence of anemia, it is unclear as to what extent ID can affect... | ['Adult', 'Colitis, Ulcerative', 'Crohn Disease', 'Cross-Sectional Studies', 'Female', 'Ferritins', 'Hemoglobins', 'Humans', 'Iron', 'Male', 'Perception', 'Prospective Studies', 'Quality of Life', 'Surveys and Questionnaires', 'Transferrin'] | 27,057,682 | [['M01.060.116'], ['C06.405.205.265.231', 'C06.405.205.731.249', 'C06.405.469.158.188.231', 'C06.405.469.432.249'], ['C06.405.205.731.500', 'C06.405.469.432.500'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['D12.776.157.427.249', 'D12.776.556.579.249'], ['D12.776.124.400', 'D12.776.... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
[Experience with the use of cyclophosphamide in multiple sclerosis]. | The effect of cyclophosphamid on the development of disseminated sclerosis was studied in 85 patients. For this purpose the authors used a special scale for the assessment of neurological expressions of the disease and the remote results of treatment. The effectiveness depended mainly on the degree of severity. Satisfa... | ['Adolescent', 'Adult', 'Blood Proteins', 'Cyclophosphamide', 'Humans', 'Middle Aged', 'Multiple Sclerosis'] | 842,238 | [['M01.060.057'], ['M01.060.116'], ['D12.776.124'], ['D02.455.526.728.650.730.243', 'D02.705.672.500.243'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C10.114.375.500', 'C10.314.350.500', 'C20.111.258.250.500']] | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Synergy of fosmidomycin (FR-31564) and other antimicrobial agents. | Fosmidomycin (FR-31564), a phosphonic acid derivative, was combined with cefazolin, cephalexin, ampicillin, carbenicillin, ticarcillin, gentamicin, and trimethoprim. Synergy between fosmidomycin and penicillins or cephalosporins was found for 37 to 52% of the Enterobacteriaceae tested. Synergy with trimethoprim was fou... | ['Anti-Bacterial Agents', 'Bacteria', 'Drug Resistance, Microbial', 'Drug Synergism', 'Fosfomycin', 'Microbial Sensitivity Tests'] | 7,181,471 | [['D27.505.954.122.085'], ['B03'], ['G06.225', 'G07.690.773.984.269'], ['G07.690.773.968.477'], ['D02.705.429.625'], ['E01.370.225.875.595', 'E05.200.875.595', 'E05.337.550.400']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Implant success in distracted bone versus autogenous bone-grafted sites. | Endosseous implants are the treatment of choice for restoring function and reconstructing most edentulous areas of the maxilla and mandible. In general, alveolar bone defects can be reconstructed by either distraction osteogenesis or autogenous bone grafting. After alveolar reconstruction, endosseous implants are used ... | ['Alveolar Ridge Augmentation', 'Bone Transplantation', 'Dental Arch', 'Dental Implantation, Endosseous', 'Dental Implants', 'Dental Restoration Failure', 'Follow-Up Studies', 'Humans', 'Jaw, Edentulous', 'Mandible', 'Maxilla', 'Osteogenesis, Distraction', 'Reconstructive Surgical Procedures', 'Retrospective Studies', ... | 19,813,422 | [['E04.545.550.100', 'E06.645.550.100'], ['E02.095.147.725.052', 'E04.555.130', 'E04.936.580.052'], ['A02.835.232.781.324.502.320', 'A14.521.320'], ['E04.545.550.280.280', 'E04.650.230.500', 'E06.645.550.280.280', 'E06.780.314.310'], ['D25.339.312', 'E06.780.346.593', 'E07.695.185', 'J01.637.051.339.312'], ['E06.323.40... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Vertebral body cage use in thoracolumbar fractures: outcomes in a prospective series of 23 cases at 2 years' follow-up. | INTRODUCTION: One objective of surgery in thoracolumbar spine fracture is to restore correct and lasting spinal statics. This may involve vertebral body replacement using an anterior approach. We here report results on a prospective series of 23 trauma patients managed by vertebral body replacement using an expandable ... | ['Adolescent', 'Adult', 'Female', 'Follow-Up Studies', 'Humans', 'Lumbar Vertebrae', 'Male', 'Middle Aged', 'Prospective Studies', 'Prostheses and Implants', 'Retrospective Studies', 'Spinal Fractures', 'Spinal Fusion', 'Thoracic Vertebrae', 'Time Factors', 'Young Adult'] | 21,862,433 | [['M01.060.057'], ['M01.060.116'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.232.834.519'], ['M01.060.116.630'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['E07.69... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[TORSION OF FALLOPIAN TUBE LEIOMYOMA TREATED BY LAPAROSCOPY]. | Leiomyomas of the Fallopian tubes are rare and their correct diagnosis is extremely difficult. Usually they are incidental findings seen at autopsy or unrelated surgical procedures: A 34-year-old woman presented with lower abdominal pain. Transvaginal ultrasound revealed a solid 7 cm extrauterine mass. Both ovaries are... | ['Abdominal Pain', 'Adult', 'Fallopian Tube Neoplasms', 'Fallopian Tubes', 'Female', 'Humans', 'Laparoscopy', 'Leiomyoma'] | 27,509,659 | [['C23.888.592.612.054', 'C23.888.821.030'], ['M01.060.116'], ['C04.588.945.418.365', 'C13.351.500.056.390.390', 'C13.351.937.418.365'], ['A05.360.319.114.373', 'A13.706.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.388.250.520', 'E04.502.250.520'], ['C04.557.450.590.450']] | ['Diseases [C]', 'Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Efficacy comparison of gel-based, membrane and glass array techniques to detect human antibodies isotypes among the Egyptian HCV-patients. | Hepatitis C virus is a major public health problem leading to cirrhosis and increased risk for development of hepatocellular carcinoma, both leading indications for liver transplantation. Egypt has the highest prevalence of hepatitis C of worldwide. Anti-HCV antibody is usually detected by enzyme immunoassay (EIA). Mic... | ['Egypt', 'Enzyme-Linked Immunosorbent Assay', 'Female', 'Hepacivirus', 'Hepatitis C Antibodies', 'Hepatitis C, Chronic', 'Humans', 'Immunoglobulin Isotypes', 'Male', 'Protein Array Analysis'] | 19,029,663 | [['Z01.058.266.317'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['B04.450.380', 'B04.820.578.344.475'], ['D12.776.124.486.485.114.254.450.510', 'D12.776.124.790.651.114.254.450.510', 'D12.776.377.715.548.114.254.450.510'], ['C01.221.250.750.120'... | ['Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Can CAD/CAM resin blocks be considered as substitute for conventional resins? | OBJECTIVE: Dentists are facing a myriad of new CAD/CAM product for dental filling therapies. Are the new materials any worthwhile using? Are they succeeding the standard filling materials? Here we compare for the first time the new resin-composite blocks (RCBs) with conventional materials (Filtek Z250 and Tetric EvoCer... | ['Cell Line', 'Ceramics', 'Chromatography, High Pressure Liquid', 'Composite Resins', 'Computer-Aided Design', 'Dental Materials', 'Epithelial Cells', 'Fibroblasts', 'Gingiva', 'Hardness', 'Humans', 'Light-Curing of Dental Adhesives', 'Materials Testing', 'Microscopy, Electron, Scanning', 'Spectrometry, X-Ray Emission'... | 28,951,036 | [['A11.251.210'], ['J01.637.153'], ['E05.196.181.400.300'], ['D05.750.716.822.308', 'D25.339.816.500', 'D25.720.716.822.308', 'J01.637.051.339.816.500', 'J01.637.051.720.716.822.308'], ['L01.224.108.150', 'L01.296.110.150'], ['D25.339', 'D27.720.102.339', 'J01.637.051.339'], ['A11.436'], ['A11.329.228'], ['A14.549.167.... | ['Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Information Science [L]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Regulation of ApoB secretion by the low density lipoprotein receptor requires exit from the endoplasmic reticulum and interaction with ApoE or ApoB. | Apolipoprotein B (apoB) is required for the hepatic assembly and secretion of very low density lipoprotein (VLDL). The LDL receptor (LDLR) promotes post-translational degradation of apoB and thereby reduces VLDL particle secretion. We investigated the trafficking pathways and ligand requirements for the LDLR to promote... | ['Adenoviridae', 'Animals', 'Apolipoproteins B', 'Apolipoproteins E', 'Brefeldin A', 'Endoplasmic Reticulum', 'Gene Expression Regulation', 'Hepatocytes', 'Ligands', 'Mice', 'Mice, Inbred C57BL', 'Models, Biological', 'Mutation', 'Protein Binding', 'Receptors, LDL'] | 18,272,520 | [['B04.280.030'], ['B01.050'], ['D10.532.091.300', 'D12.776.070.400.300', 'D12.776.521.120.300'], ['D10.532.091.500', 'D12.776.070.400.500', 'D12.776.521.120.500'], ['D02.540.576.500.875'], ['A11.284.430.214.190.875.248'], ['G05.308'], ['A11.436.348'], ['D27.720.470.480'], ['B01.050.150.900.649.313.992.635.505.500'], [... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Early trends in serum phosphate and creatinine levels are associated with mortality following major hepatectomy. | BACKGROUND: Mortality after major hepatectomy remains high and is frequently related to post-hepatectomy liver failure (PHLF). Other than pre-existing liver disease and a small future liver remnant, few patient factors or early postoperative indicators identify patients at elevated risk for PHLF and mortality.METHODS: ... | ['Aged', 'Biomarkers', 'Blood Loss, Surgical', 'Comorbidity', 'Creatinine', 'Databases, Factual', 'Female', 'Hepatectomy', 'Humans', 'Liver Neoplasms', 'Male', 'Middle Aged', 'Phosphates', 'Risk Assessment', 'Risk Factors', 'Time Factors', 'Treatment Outcome', 'Up-Regulation'] | 26,385,577 | [['M01.060.116.100'], ['D23.101'], ['C23.550.414.300', 'C23.550.505.300'], ['N05.715.350.225', 'N06.850.490.687'], ['D03.383.129.308.207'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['E04.210.556'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.274.623', 'C06.301.623', 'C06.552.697'], ['M01.060.1... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Health Care [N]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
[Continuous epidural anesthesia with a double catheter for sedation for surgery of the vertebral dorsolumbar column]. | The case of presented of an obese 42 year-old female patient, undergoing a second spinal cord decompression for a large dorsolumbar fibrous-scar mass, having a small-bore Montgomery tracheal stent (T-tube) on site. Stent replacement with a tracheotomy tube was impossible because of strong accretions hindering stent rem... | ['Adult', 'Anesthesia, Epidural', 'Catheterization', 'Decompression, Surgical', 'Female', 'Humans', 'Lumbar Vertebrae', 'Obesity', 'Spinal Cord Compression'] | 10,522,137 | [['M01.060.116'], ['E03.155.086.131'], ['E02.148', 'E05.157'], ['E04.188'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.232.834.519'], ['C18.654.726.500', 'C23.888.144.699.500', 'E01.370.600.115.100.160.120.699.500', 'G07.100.100.160.120.699.500'], ['C10.228.854.761', 'C26.819.678']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Cognitive Function in Individuals with Normal Weight Obesity: Results from the Third National Health and Nutrition Examination Survey (NHANES III). | BACKGROUND/OBJECTIVE: Normal weight obesity (NWO) is associated with increased risk of metabolic syndrome, cardiovascular- and all-cause mortality. However, no data have been reported on the relationship between adiposity and cognitive performance in NWO. We therefore studied the association between cognitive function ... | ['Adult', 'Age Distribution', 'Body Mass Index', 'Cognition Disorders', 'Cross-Sectional Studies', 'Electric Impedance', 'Female', 'Humans', 'Male', 'Middle Aged', 'Neuropsychological Tests', 'Nutrition Surveys', 'Obesity', 'Problem Solving', 'Reaction Time', 'United States', 'Young Adult'] | 30,010,127 | [['M01.060.116'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['F03.615.250'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['G01.358.500.249.277.350'], ['B01.050.150.900.649.313.98... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Congenital gigantism due to growth hormone-releasing hormone excess and pituitary hyperplasia with adenomatous transformation. | The cause of gigantism in most patients is a GH-secreting pituitary tumor. In this report, a case of congenital gigantism due to probable central hypersection of GH-releasing hormone (GHRH) is described. Normal at birth (4.4 kg; 53 cm), our 7-yr-old male patient grew progressively thereafter to attain a height of 182 c... | ['Adenoma', 'Bromocriptine', 'Cell Transformation, Neoplastic', 'Child', 'Gigantism', 'Growth Hormone', 'Growth Hormone-Releasing Hormone', 'Humans', 'Hyperplasia', 'Magnetic Resonance Imaging', 'Male', 'Octreotide', 'Pituitary Gland', 'Pituitary Neoplasms', 'Prolactin'] | 8,421,089 | [['C04.557.470.035'], ['D03.132.327.412.100', 'D03.633.400.439.131', 'D03.633.400.562.100'], ['C04.697.098.500', 'C23.550.727.098.500'], ['M01.060.406'], ['C05.116.099.492', 'C05.116.132.479', 'C19.700.355.528'], ['D06.472.699.631.525.425', 'D12.644.548.691.525.425'], ['D06.472.699.327.740.860', 'D12.644.400.400.740.86... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Spatiotemporal detection and analysis of exocytosis reveal fusion "hotspots" organized by the cytoskeleton in endocrine cells. | Total internal reflection fluorescence microscope has often been used to study the molecular mechanisms underlying vesicle exocytosis. However, the spatial occurrence of the fusion events within a single cell is not frequently explored due to the lack of sensitive and accurate computer-assisted programs to analyze larg... | ['Actin Cytoskeleton', 'Animals', 'Cell Line', 'Exocytosis', 'Insulin-Secreting Cells', 'Membrane Fusion', 'Microscopy, Fluorescence', 'Rats', 'Secretory Vesicles'] | 25,606,674 | [['A11.284.430.214.190.750.050'], ['B01.050'], ['A11.251.210'], ['G04.468'], ['A03.734.414.131', 'A06.300.414.087', 'A06.390.131', 'A11.382.625.092', 'A11.436.294.092'], ['G04.575'], ['E01.370.350.515.458', 'E05.595.458'], ['B01.050.150.900.649.313.992.635.505.700'], ['A11.284.430.214.190.875.190.880.810']] | ['Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Circadian locomotor activity of Musca flies: recording method and effects of 10 Hz square-wave electric fields. | Musca domestica flies that were exposed to a uniform vertical 10 Hz electric square-wave field of 1 kVm(-1) changed the period length of their circadian locomotor activity rhythm. Under constant conditions, the clock of short-period flies was slowed down by the field, whereas the clock of long-period flies either was a... | ['Animals', 'Circadian Rhythm', 'Electromagnetic Fields', 'Female', 'Houseflies', 'Humans', 'Male', 'Motor Activity'] | 9,139,632 | [['B01.050'], ['G07.180.562.190'], ['G01.358.500.260', 'G01.358.750.500'], ['B01.050.500.131.617.720.500.500.750.642.470'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.632', 'G11.427.410.698']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Middle cranial fossa acoustic neuroma excision: results and complications. | The middle cranial fossa surgical approach has been used for the removal of acoustic neuromas in 43 patients at the University of Iowa since 1974. Hearing was maintained in 50% of patients with tumors 1.5 cm or less outside the porus acusticus. Postoperative hearing, facial nerve function, and complications were simila... | ['Adult', 'Facial Nerve', 'Female', 'Hearing', 'Humans', 'Male', 'Methods', 'Middle Aged', 'Neuroma, Acoustic', 'Postoperative Complications'] | 3,767,216 | [['M01.060.116'], ['A08.800.050.050.275', 'A08.800.050.600.149', 'A08.800.800.060.275', 'A08.800.800.120.250'], ['F02.830.816.263', 'G07.888.500', 'G11.561.790.263'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.581'], ['M01.060.116.630'], ['C04.557.465.625.650.595.610', 'C04.557.580.600.610.595.610', 'C04.55... | ['Named Groups [M]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
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