Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Impact of a chronic disease self-management program on health care utilization in rural communities: a retrospective cohort study using linked administrative data. | BACKGROUND: Internationally, chronic disease self-management programs (CDSMPs) have been widely promoted with the assumption that confident, knowledgeable patients practicing self-management behavior will experience improved health and utilize fewer healthcare resources. However, there is a paucity of published data su... | ['Aged', 'Chronic Disease', 'Confidence Intervals', 'Databases, Factual', 'Female', 'Humans', 'Male', 'Middle Aged', 'Odds Ratio', 'Ontario', 'Patient Acceptance of Health Care', 'Retrospective Studies', 'Rural Health Services', 'Self Care', 'Self Report'] | 24,885,135 | [['M01.060.116.100'], ['C23.550.291.500'], ['E05.318.740.275', 'N05.715.360.750.220', 'N06.850.520.830.275'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.740.600.600', 'G17.680.500', 'N05.715.360.750.625.590', 'N06.850.520.830.600.6... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Information Science [L]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
Nature of phenolic compounds in coffee melanoidins. | Phenolic compounds are incorporated into coffee melanoidins during roasting mainly in condensed form (42-62 mmol/100 g) and also in ester-linked form (1.1-1.6 mmol/100 g), with incorporation levels depending on the green coffee chlorogenic acid content. The phenolic compounds are incorporated in different coffee melano... | ['Caffeine', 'Chlorogenic Acid', 'Coffea', 'Coffee', 'Food Handling', 'Hot Temperature', 'Phenols', 'Polymers', 'Seeds'] | 24,998,624 | [['D03.132.960.175', 'D03.633.100.759.758.824.175'], ['D02.241.223.200.185', 'D02.241.223.268.220'], ['B01.650.940.800.575.912.250.456.937.275'], ['D20.215.784.249', 'G07.203.100.325', 'J02.200.325'], ['J01.576.423.200'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.775.710.380', 'N06.230.300.100.725... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Change over time in parents' beliefs about and reported use of corporal punishment in eight countries with and without legal bans. | Stopping violence against children is prioritized in goal 16 of the Sustainable Development Goals adopted by the United Nations General Assembly in 2015. All forms of child corporal punishment have been outlawed in 50 countries as of October 2016. Using data from 56,371 caregivers in eight countries that participated i... | ['Adolescent', 'Child', 'Child, Preschool', 'Cross-Cultural Comparison', 'Culture', 'Female', 'Humans', 'Male', 'Parenting', 'Physical Abuse', 'Punishment', 'Surveys and Questionnaires', 'United Nations'] | 28,277,271 | [['M01.060.057'], ['M01.060.406'], ['M01.060.406.448'], ['I01.076.201.450.281', 'I01.880.853.100.257'], ['I01.076.201.450', 'I01.880.853.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.263.370.310'], ['I01.198.240.856.688', 'I01.880.735.900.744'], ['F02.463.425.770.571', 'I01.880.630.716'], ['E05.318.... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Plasma N-terminal pro-brain natriuretic peptide and adrenomedullin: new neurohormonal predictors of left ventricular function and prognosis after myocardial infarction. | BACKGROUND: Newly discovered circulating peptides, N-terminal pro-brain natriuretic peptide (N-BNP) and adrenomedullin (ADM), were examined for prediction of cardiac function and prognosis and compared with previously reported markers in 121 patients with myocardial infarction.METHODS AND RESULTS: The association betwe... | ['Adrenomedullin', 'Atrial Natriuretic Factor', 'Biomarkers', 'Cyclic GMP', 'Epinephrine', 'Female', 'Heart', 'Humans', 'Male', 'Middle Aged', 'Myocardial Infarction', 'Myocardial Ischemia', 'Natriuretic Peptide, Brain', 'Nerve Tissue Proteins', 'Norepinephrine', 'Peptides', 'Predictive Value of Tests', 'Prognosis', 'R... | 9,609,085 | [['D06.472.699.077', 'D12.644.548.017'], ['D06.472.699.584.500', 'D12.644.548.585.500'], ['D23.101'], ['D03.633.100.759.646.454.160', 'D13.695.462.275', 'D13.695.667.454.160', 'D13.695.827.426.160'], ['D02.033.100.291.310', 'D02.092.063.291.310', 'D02.092.211.215.454', 'D02.092.311.461', 'D02.455.426.559.389.657.166.17... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Circadian rhythms of epinephrine and norepinephrine in man. | The diurnal rhythms of plasma epinephrine and norepinephrine were investigated in a group of normal young men. Sleep, posture, illumination, and food intake were monitored. Plasma epinephrine demonstrated a statistically significant diurnal rhythm, with a mean amplitude of 14 +/- 1.6 (+/- SE) pg/ml superimposed on a me... | ['Blood Specimen Collection', 'Circadian Rhythm', 'Eating', 'Epinephrine', 'Humans', 'Male', 'Norepinephrine', 'Posture', 'Sleep'] | 3,998,066 | [['E01.370.225.998.110', 'E04.665.150', 'E05.200.998.110'], ['G07.180.562.190'], ['G07.203.650.283', 'G10.261.330'], ['D02.033.100.291.310', 'D02.092.063.291.310', 'D02.092.211.215.454', 'D02.092.311.461', 'D02.455.426.559.389.657.166.175.461'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.033.100.291.502', '... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Spatially-Resolved Top-down Proteomics Bridged to MALDI MS Imaging Reveals the Molecular Physiome of Brain Regions. | Tissue spatially-resolved proteomics was performed on 3 brain regions, leading to the characterization of 123 reference proteins. Moreover, 8 alternative proteins from alternative open reading frames (AltORF) were identified. Some proteins display specific post-translational modification profiles or truncation linked t... | ['Animals', 'Brain', 'Male', 'Proteome', 'Proteomics', 'Rats, Wistar', 'Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization'] | 29,122,912 | [['B01.050'], ['A08.186.211'], ['D12.776.817'], ['H01.158.201.843', 'H01.158.273.180.350.700', 'H01.158.273.343.350.700', 'H01.181.122.738'], ['B01.050.150.900.649.313.992.635.505.700.900'], ['E05.196.566.755']] | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
How going with the flow led to a better patient journey. | A new £60m hospital building was the catalyst for an improve system of patient flow that was to transform the public's experience of Morriston Hospital in Swansea. | ['Delivery of Health Care, Integrated', 'Efficiency, Organizational', 'Hospital Design and Construction', 'Humans', 'Organizational Case Studies', 'Organizational Objectives', 'Patient Satisfaction', 'Quality Assurance, Health Care', 'State Medicine', 'Wales'] | 30,091,866 | [['N04.590.374.142', 'N05.300.262'], ['N04.452.209.500'], ['J01.086.339.250', 'N02.278.200.403'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.349.380.710', 'N05.715.360.455'], ['N04.452.615'], ['F01.100.150.750.625', 'F01.145.488.887.625', 'N04.452.822.700', 'N05.300.150.800.625', 'N05.715.360.600'], ['N04.7... | ['Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
Mitochondrial DNA polymorphisms associated with longevity in a Finnish population. | Sequence variation in mitochondrial DNA (mtDNA) may cause slight differences both in the functioning of the respiratory chain and in free radical production, and an association between certain mtDNA haplogroups and longevity has been suggested. In order to determine further the role of mtDNA in longevity, we studied th... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Aging', 'DNA, Mitochondrial', 'Female', 'Finland', 'Gene Frequency', 'Haplotypes', 'Hospital Records', 'Humans', 'Infant', 'Longevity', 'Male', 'Middle Aged', 'Phylogeny', 'Polymorphism, Genetic', 'Polymorphism, Restriction Fragment Length', 'Residence Characteristi... | 12,483,296 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['G07.345.124'], ['D13.444.308.283.225'], ['Z01.542.816.186'], ['G05.330'], ['G05.380.360'], ['E05.318.308.940.425', 'L01.399.250.900.425', 'N04.452.859.380', 'N05.715.360.300.715.380', 'N06.850.520.308.940.425'], ['B01.050.150.900.649.313... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
Complement Activation During Ischemia/Reperfusion Injury Induces Pericyte-to-Myofibroblast Transdifferentiation Regulating Peritubular Capillary Lumen Reduction Through pERK Signaling. | Pericytes are one of the principal sources of scar-forming myofibroblasts in chronic kidneys disease. However, the modulation of pericyte-to-myofibroblast transdifferentiation (PMT) in the early phases of acute kidney injury is poorly understood. Here, we investigated the role of complement in inducing PMT after transp... | ['Acute Kidney Injury', 'Animals', 'Cell Transdifferentiation', 'Complement Activation', 'Complement C1 Inhibitor Protein', 'Humans', 'Kidney', 'Mice', 'Mice, Inbred C57BL', 'Myofibroblasts', 'Pericytes', 'Reperfusion Injury', 'Signal Transduction', 'Swine', 'eIF-2 Kinase'] | 29,875,766 | [['C12.777.419.780.050', 'C13.351.968.419.780.050'], ['B01.050'], ['G04.356'], ['G12.274'], ['D12.644.861.140.500', 'D12.776.124.486.274.920.250.500', 'D12.776.395.320', 'D12.776.872.140.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A05.810.453'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.1... | ['Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[The preparation of nano-hydroxyapatite and preliminary observation on its effects on the occlusion of dentinal tubule]. | OBJECTIVE: To synthesize nano-hydroxyapatite (nano-HA) and evaluate its effect on the occlusion of dentinal tubules in vitro, and therefore provide evidence for the clinical application.METHODS: (NH(4))(2)HPO(4) and Ca(NO3)2 were used to form nano-HA, which was characterized by scanning electron microscopy (SEM), trans... | ['Caseins', 'Dental Materials', 'Dentin', 'Dentin Sensitivity', 'Durapatite', 'Humans', 'Materials Testing', 'Nanostructures', 'Technology, Dental'] | 19,575,989 | [['D12.776.256.159.750.207', 'D12.776.744.150'], ['D25.339', 'D27.720.102.339', 'J01.637.051.339'], ['A14.549.167.900.280'], ['C07.793.266'], ['D01.029.260.700.675.374.075.025.300.150', 'D01.146.360.050.300.200', 'D01.578.122.477.300', 'D01.695.625.675.650.075.025.300.150'], ['B01.050.150.900.649.313.988.400.112.400.40... | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Femtosecond response of polyatomic molecules to ultra-intense hard X-rays. | X-ray free-electron lasers enable the investigation of the structure and dynamics of diverse systems, including atoms, molecules, nanocrystals and single bioparticles, under extreme conditions. Many imaging applications that target biological systems and complex materials use hard X-ray pulses with extremely high peak ... | ['Crystallography', 'Electrons', 'Iodine', 'Kinetics', 'Lasers', 'Photons', 'Protein Conformation', 'Proteins', 'Static Electricity', 'Time Factors', 'X-Rays'] | 28,569,799 | [['E05.196.309', 'H01.181.529.240'], ['G01.249.335', 'G01.358.500.750'], ['D01.268.380.400'], ['G01.374.661', 'G02.111.490'], ['E07.632.490', 'E07.710.520'], ['G01.249.705', 'G01.358.500.505.650.782', 'G01.590.540.782', 'G01.750.250.650.782', 'G01.750.770.578.782'], ['G02.111.570.820.709'], ['D12.776'], ['G01.358.500.2... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Epidemiologic aspects of an outbreak of acquired immunodeficiency in rhesus monkeys (Macaca mulatta). | Since August 25, 1981, an outbreak of simian acquired immunodeficiency syndrome ( SAIDS ) has been recognized in a single outdoor corral housing 77 rhesus monkeys (Macaca mulatta) over a 16-month period. The etiology of this syndrome is unknown but epidemiologic evidence suggests an infectious agent. Thirty-two cases o... | ['Acquired Immunodeficiency Syndrome', 'Age Factors', 'Animals', 'Animals, Laboratory', 'California', 'Disease Outbreaks', 'Female', 'Fibrosarcoma', 'Macaca', 'Macaca mulatta', 'Male', 'Monkey Diseases', 'Skin Neoplasms'] | 6,727,287 | [['C01.221.250.875.040', 'C01.221.812.640.400.040', 'C01.778.640.400.040', 'C01.925.782.815.616.400.040', 'C01.925.813.400.040', 'C01.925.839.040', 'C20.673.480.040'], ['N05.715.350.075', 'N06.850.490.250'], ['B01.050'], ['B01.050.050.199'], ['Z01.107.567.875.580.200', 'Z01.107.567.875.760.200'], ['N06.850.290'], ['C04... | ['Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Efficient drug delivery to lung epithelial lining fluid by aerosolization of ciprofloxacin incorporated into PEGylated liposomes for treatment of respiratory infections. | PURPOSE: The efficacy of aerosolization of ciprofloxacin (CPFX) incorporated into PEGylated liposomes (PEGylated CPFX-liposomes) for the treatment of respiratory infections was evaluated.METHOD: PEGylated CPFX-liposomes with 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-n-[methoxy(polyethylene glycol)-2000] (particle... | ['Aerosols', 'Animals', 'Anti-Infective Agents', 'Area Under Curve', 'Ciprofloxacin', 'Drug Delivery Systems', 'Epithelium', 'L-Lactate Dehydrogenase', 'Liposomes', 'Lung', 'Male', 'Polyethylene Glycols', 'Rats', 'Rats, Sprague-Dawley', 'Respiratory Tract Infections'] | 20,815,792 | [['D20.280.055', 'D26.255.165.055'], ['B01.050'], ['D27.505.954.122'], ['E05.318.740.200', 'G03.787.101', 'G07.690.725.064', 'N06.850.520.830.200'], ['D03.633.100.810.835.322.186'], ['E02.319.300'], ['A10.272'], ['D08.811.682.047.551.400', 'D08.811.682.047.820.493'], ['D25.479.517', 'D26.255.260.517', 'J01.637.051.479.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Genome-wide signatures of transcription factor activity: connecting transcription factors, disease, and small molecules. | Identifying transcription factors (TF) involved in producing a genome-wide transcriptional profile is an essential step in building mechanistic model that can explain observed gene expression data. We developed a statistical framework for constructing genome-wide signatures of TF activity, and for using such signatures... | ['Chromatin Immunoprecipitation', 'Disease', 'Gene Expression Profiling', 'Genome-Wide Association Study', 'Humans', 'Probability', 'Transcription Factors'] | 24,039,560 | [['E05.393.170', 'E05.478.605.160'], ['C23.550.288'], ['E05.393.332'], ['E05.318.370.392', 'E05.318.416.249', 'E05.393.385.500', 'E05.393.522.500', 'E05.393.760.640.500', 'N06.850.520.445.392', 'N06.850.520.470.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.600', 'G17.680', 'N05.715.360.750.625',... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Twenty-four-hour cortisol response to multiple daily exercise sessions of moderate and high intensity. | The aim of this study was to characterize and describe the cortisol responses in athletes over a 24-h period on different days involving multiple exercise sessions of varied intensity. Seventeen endurance athletes volunteered to undergo three experimental treatment conditions: (a) a control day involving no exercise; (... | ['Adolescent', 'Adult', 'Anaerobiosis', 'Bicycling', 'Exercise', 'Humans', 'Hydrocortisone', 'Male', 'Oxygen Consumption', 'Time Factors'] | 10,200,900 | [['M01.060.057'], ['M01.060.116'], ['G02.111.062', 'G03.078'], ['I03.450.642.845.140'], ['G11.427.410.698.277', 'I03.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D04.210.500.745.745.654.600', 'D06.472.040.585.353.476', 'D06.472.040.585.478.392'], ['G03.680'], ['G01.910.857']] | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Psychological distress and treatment adherence among children on dialysis. | Among 23 pediatric renal dialysis patients, we obtained self-reported assessments of psychological adjustment and biochemical and subjective ratings of adherence. Findings indicate elevated levels of depressive symptoms and substantial nonadherence. Depressive symptoms were associated with higher levels of hopelessness... | ['Adolescent', 'Biomarkers', 'Calcium', 'Child', 'Depression', 'Female', 'Humans', 'Male', 'Patient Compliance', 'Phosphorus', 'Renal Dialysis', 'Stress, Psychological'] | 9,323,288 | [['M01.060.057'], ['D23.101'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['M01.060.406'], ['F01.145.126.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.100.150.750.500.600', 'F01.145.488.887.500.600', 'N05.300.150.800.500.600'], ['D01.268.666'], ['E02.870.300', 'E02.912.800'], ['F01.145.126.9... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Characterization of chloroplast protein import without Tic56, a component of the 1-megadalton translocon at the inner envelope membrane of chloroplasts. | We report on the characterization of Tic56, a unique component of the recently identified 1-MD translocon at the inner envelope membrane of chloroplasts (TIC) in Arabidopsis (Arabidopsis thaliana) comprising Tic20, Tic100, and Tic214. We isolated Tic56 by copurification with Tandem Affinity Purification-tagged Toc159 i... | ['Arabidopsis', 'Arabidopsis Proteins', 'Blotting, Western', 'Chloroplasts', 'Intracellular Membranes', 'Isotope Labeling', 'Membrane Transport Proteins', 'Molecular Weight', 'Mutation', 'Peptides', 'Plant Leaves', 'Protein Transport', 'Substrate Specificity'] | 25,588,737 | [['B01.650.940.800.575.912.250.157.100'], ['D12.776.765.149'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['A11.284.430.214.190.875.700.140'], ['A11.284.149.450', 'A11.284.835.514'], ['E05.522'], ['D12.776.157.530', 'D12.776.543.585'], ['G02.494'], ['G05.365.590... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cholinergic neuronotrophic factors: I. Survival, neurite outgrowth and choline acetyltransferase activity in monolayer cultures from chick embryo ciliary ganglia. | Two key components of neural development and regeneration, survival of the involved neurons and elongation of neuritic elements, are likely to depend on the availability of an appropriate trophic drive to these neurons. At present, only one trophic factor, Nerve Growth Factor, is known to ensure both survival and neuri... | ['Animals', 'Cell Count', 'Cell Survival', 'Chick Embryo', 'Choline O-Acetyltransferase', 'Choroid', 'Culture Media', 'Culture Techniques', 'Ganglia', 'Nerve Growth Factors', 'Nerve Regeneration', 'Neurons', 'Receptors, Cholinergic'] | 487,083 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Synthesis and biological evaluation of 6-aryl-6H-pyrrolo[3,4-d]pyridazine derivatives: high-affinity ligands to the alpha 2 delta subunit of voltage gated calcium channels. | A novel class of 6-aryl-6H-pyrrolo[3,4-d]pyridazine ligands for the alpha2delta subunit of voltage-gated calcium channels has been described. Substitutions in the aryl ring of the molecule were generally not tolerated, and resulted in diminished binding to the alpha2delta subunit. Modifications to the pyridazine ring r... | ['Animals', 'Calcium Channels', 'Drug Evaluation, Preclinical', 'Ligands', 'Pain Threshold', 'Protein Binding', 'Protein Subunits', 'Pyridazines', 'Rats'] | 14,980,685 | [['B01.050'], ['D12.776.157.530.400.150', 'D12.776.543.550.450.150', 'D12.776.543.585.400.150'], ['E05.290.750', 'E05.337.550'], ['D27.720.470.480'], ['F02.463.593.710.560', 'F02.830.816.444.700', 'G11.561.790.444.700'], ['G02.111.679', 'G03.808'], ['D12.776.813'], ['D03.383.710'], ['B01.050.150.900.649.313.992.635.505... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Immunologic status in physiological pregnancy]. | The levels of T gamma- and T mu-lymphocytes, functional activity of ConA-induced T-suppressors and the concentrations of SP1 and SP3 were determined in 164 normal pregnant women during 8-40 weeks of gestation. It is found that formation of the suppressor dominant is necessary for the immunological maintenance during 8-... | ['Female', 'Humans', 'Immune Tolerance', 'Leukocyte Count', 'Pregnancy', 'Pregnancy Trimester, First', 'Pregnancy Trimester, Second', 'Pregnancy Trimester, Third', 'T-Lymphocytes, Helper-Inducer', 'T-Lymphocytes, Regulatory'] | 2,531,686 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['G12.535.425'], ['E01.370.225.500.195.107.595', 'E01.370.225.625.107.595', 'E05.200.500.195.107.595', 'E05.200.625.107.595', 'E05.242.195.107.595', 'G04.140.107.595', 'G09.188.105.595'], ['G08.686.784.769'], ['G08.686.707.408'], ['G08.686.707.490'], ['G08.686.707.520']... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Synthesis and purine receptor affinity of 6-oxopurine nucleosides and nucleotides containing (N)-methanocarba-pseudoribose rings. | 6-Oxopurine derivatives containing a northern (N) methanocarba modification (i.e., fused cyclopropane and cyclopentane rings in place of the ribose) were synthesized and the adenosine receptor affinity measured. Guanine or hypoxanthine was coupled at the 7-position, or 1,3-dibutylxanthine was coupled at the 9-position.... | ['Calcium', 'Drug Evaluation, Preclinical', 'Guanine', 'HL-60 Cells', 'Humans', 'Hypoxanthine', 'Nucleosides', 'Nucleotides', 'Purinergic P1 Receptor Agonists', 'Receptor, Adenosine A2A', 'Receptor, Adenosine A3', 'Receptors, Purinergic P1', 'Structure-Activity Relationship'] | 11,527,718 | [['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['E05.290.750', 'E05.337.550'], ['D03.633.100.759.758.399.454'], ['A11.251.210.190.465', 'A11.251.860.180.465', 'A11.627.340.360.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.633.100.759.758.399.475'], ['D09.408.595', 'D13.570'], ['D09.408.620', 'D... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The effect of intravenous diazepam on esophageal motility in normal subjects. | Controversy exists over whether diazepam can be used for sedation during esophageal manometry studies without affecting the results. To evaluate the effect of diazepam, 20 healthy asymptomatic volunteers were studied using a standard manometry protocol employing an Arndorfer capillary infusion system. Following a basel... | ['Adult', 'Depression, Chemical', 'Diazepam', 'Esophagogastric Junction', 'Esophagus', 'Evaluation Studies as Topic', 'Female', 'Humans', 'Male', 'Manometry', 'Muscle Contraction', 'Peristalsis', 'Premedication', 'Pressure'] | 1,864,196 | [['M01.060.116'], ['G07.690.773.750'], ['D03.633.100.079.080.070.216'], ['A03.556.875.500.414', 'A03.556.875.875.330'], ['A03.556.875.500'], ['E05.337', 'N05.715.360.335'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.559'], ['G11.427.494'], ['G10.261.360.596'], ['E02.319.703'], ['G01.374.715']] | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Redescription of Ryukyua circularis (Pillai, 1954) (Isopoda, Cymothoidae), parasite of the Bleeker smoothbelly sardinella Amblygaster clupeoides Bleeker, 1849 from India. | Ryukyua circularis (Pillai, 1954) is recorded here for the first time on the host Amblygaster clupeoides Bleeker, 1849 from Indian waters. The species is redescribed with illustrations of the gravid female, adult male and manca from its type locality, and the known hosts and geographical records of the species are revi... | ['Animals', 'Female', 'Fishes', 'Geography', 'India', 'Isopoda', 'Male', 'Parasites'] | 30,651,524 | [['B01.050'], ['B01.050.150.900.493'], ['H01.277.500'], ['Z01.252.245.393'], ['B01.050.500.131.365.400'], ['B01.050.500.714']] | ['Organisms [B]', 'Disciplines and Occupations [H]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 |
Poly(vinyl methyl ether/maleic anhydride)-Doped PEG-PLA Nanoparticles for Oral Paclitaxel Delivery To Improve Bioadhesive Efficiency. | Bioadhesive nanoparticles based on poly(vinyl methyl ether/maleic anhydride) (PVMMA) and poly(ethylene glycol) methyl ether-b-poly(d,l-lactic acid) (mPEG-b-PLA) were produced by the emulsification solvent evaporation method. Paclitaxel was utilized as the model drug, with an encapsulation efficiency of up to 90.2 ± 4.0... | ['A549 Cells', 'Administration, Oral', 'Animals', 'Antineoplastic Agents, Phytogenic', 'Biological Availability', 'Caco-2 Cells', 'Coumarins', 'Delayed-Action Preparations', 'Drug Carriers', 'Drug Compounding', 'Drug Liberation', 'HT29 Cells', 'Humans', 'Intestinal Mucosa', 'Male', 'Maleates', 'Mice', 'Models, Animal',... | 28,892,400 | [['A11.251.210.190.080', 'A11.251.860.180.080', 'A11.436.054'], ['E02.319.267.100'], ['B01.050'], ['D27.505.954.248.179'], ['G03.787.151', 'G07.690.725.129'], ['A11.251.210.190.160', 'A11.251.860.180.160', 'A11.436.140'], ['D03.383.663.283.446', 'D03.633.100.150.446'], ['D26.255.210', 'E02.319.300.253'], ['D26.255.260'... | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Evaluation of a prognostic scoring system based on the systemic inflammatory and nutritional status of patients with locally advanced non-small-cell lung cancer treated with chemoradiotherapy. | Systemic inflammation and poor nutritional status have a negative effect on the outcomes of cancer. Here, we analyzed the effects of the pretreatment inflammatory and nutritional status on clinical outcomes of locally advanced non-small-cell lung cancer (NSCLC) patients treated with chemoradiotherapy. We retrospectivel... | ['Adult', 'Aged', 'Aged, 80 and over', 'Body Mass Index', 'C-Reactive Protein', 'Carcinoma, Non-Small-Cell Lung', 'Chemoradiotherapy', 'Female', 'Humans', 'Inflammation', 'Kaplan-Meier Estimate', 'Lung Neoplasms', 'Male', 'Middle Aged', 'Multivariate Analysis', 'Neoplasm Recurrence, Local', 'Neoplasm Staging', 'Nutriti... | 29,182,777 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['D12.776.034.145', 'D12.776.124.050.120', 'D12.776.124.486.157'], ['C04.588.894.797.520.109.220.249', 'C08.381.540.140.500', 'C08.785.520.100.220.500'], ['E02.18... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Geographical trends in infant mortality: England and Wales, 1970-2006. | At national level in England and Wales, infant mortality rates fell rapidly from the early 1970s and into the 1980s. Subnational areas have also experienced a reduction in levels of infant mortality. While rates continued to fall to 2006, the rate of reduction has slowed. Although the Government Office Regions Yorkshir... | ['Demography', 'England', 'Humans', 'Infant', 'Infant Mortality', 'Infant, Newborn', 'Mortality', 'Wales'] | 19,093,637 | [['I01.240', 'N01.224', 'N06.850.505.400'], ['Z01.542.363.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['E05.318.308.985.550.475', 'N01.224.935.698.489', 'N06.850.505.400.975.550.475', 'N06.850.520.308.985.550.475'], ['M01.060.703.520'], ['E05.318.308.985.550', 'N01.224.935.698', 'N06.850.50... | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Geographicals [Z]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
[Drug-induced avitaminoses and their prevention (author's transl)]. | The concept of "drug induced avitaminoses" originates from the observation that drugs may cause vitamin deficiencies. These avitaminoses belong to the "iatrogenic disvitaminoses" and can be subdivided into two groups since they may either represent unwanted side effects of a drug or may be utilized for therapeutical pu... | ['Avitaminosis', 'Humans', 'Iatrogenic Disease', 'Vitamins'] | 7,246,394 | [['C18.654.521.500.133'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.291.875'], ['D27.505.696.494.600', 'G07.203.300.681.500.600', 'J02.500.681.500.600']] | ['Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
High expression of miR-210 predicts poor survival in patients with breast cancer: a meta-analysis. | BACKGROUND: Many microRNAs (miRNAs) exhibit altered expression levels in cancers, and they may be considered as valuable prognostic biomarkers for cancers. Here we aimed to summarize the recent advances in miR-210 involvement in human breast cancer and analyze the predicting role of miR-210 for survival.METHODS: A meta... | ['Breast Neoplasms', 'Female', 'Gene Expression', 'Humans', 'Kaplan-Meier Estimate', 'MicroRNAs', 'Prognosis', 'Proportional Hazards Models', 'RNA, Neoplasm', 'Up-Regulation'] | 22,842,193 | [['C04.588.180', 'C17.800.090.500'], ['G05.297'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.998.650', 'N05.715.360.750.795.650', 'N06.850.520.830.998.650'], ['D13.150.650.319', 'D13.444.735.150.319', 'D13.444.735.790.552.500'], ['E01.789'], ['E05.318.740.500.700', 'E05.318.740.600.700', 'E05.318.74... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Analysis of regurgitation, mean systolic pressure drop and energy losses for two artificial aortic valves. | The work reported here is related to the hydrodynamic performance of a Jellyfish valve and St Vincent valve in terms of total energy losses, mean systolic pressure drop and regurgitation. The in vitro experimental investigation was conducted at cardiac outputs of 3.5, 4.5 and 6.51 min-1 across the two valves and under ... | ['Aortic Valve', 'Aortic Valve Insufficiency', 'Blood Flow Velocity', 'Blood Pressure', 'Cardiac Output', 'Heart Valve Prosthesis', 'Hemodynamics', 'Humans', 'In Vitro Techniques', 'Models, Cardiovascular', 'Models, Structural', 'Pulsatile Flow', 'Systole'] | 10,356,676 | [['A07.541.510.110'], ['C14.280.484.048.500'], ['E01.370.370.130', 'G09.330.380.630.080'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E01.370.370.380.150', 'G09.330.380.124'], ['E07.695.310'], ['G09.330.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.481'], ['E05.599.395.161'], ['J01.897.280.500.545', ... | ['Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Application of a novel automatic disintegration apparatus for the development and evaluation of a direct compression rapidly disintegrating tablet. | An automatic disintegration tester was developed and used to explore disintegration mechanism and times of rapidly disintegrating tablets. DT50, the time required for a tablet to decrease in its thickness by half, allowed an unbiased determination of disintegration time. Calcium silicate concentration, Explotab® concen... | ['Calcium Compounds', 'Chemistry, Pharmaceutical', 'Drug Compounding', 'Excipients', 'Kinetics', 'Polysaccharides', 'Silicates', 'Starch', 'Stearic Acids', 'Tablets', 'Technology, Pharmaceutical'] | 22,091,970 | [['D01.146'], ['H01.158.703.007', 'H01.181.466'], ['E05.916.270'], ['D26.650.700.419', 'D27.720.744.770.419'], ['G01.374.661', 'G02.111.490'], ['D09.698'], ['D01.578.725', 'D01.837.725.700.760'], ['D05.750.078.562.855', 'D09.301.915', 'D09.698.365.855'], ['D10.251.882'], ['D26.255.830'], ['E05.916', 'J01.897.836']] | ['Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
IGF-1 Regulates Vertebral Bone Aging Through Sex-Specific and Time-Dependent Mechanisms. | Advanced aging is associated with increased risk of bone fracture, especially within the vertebrae, which exhibit significant reductions in trabecular bone structure. Aging is also associated with a reduction in circulating levels of insulin-like growth factor (IGF-1). Studies have suggested that the reduction in IGF-1... | ['Aging', 'Animals', 'Bone Density', 'Female', 'Insulin-Like Growth Factor I', 'Male', 'Mice', 'Mice, Transgenic', 'Osteoporosis', 'RANK Ligand', 'Receptor, Insulin', 'Sex Characteristics', 'Signal Transduction', 'Spine', 'Time Factors'] | 26,260,312 | [['G07.345.124'], ['B01.050'], ['G11.427.100'], ['D12.644.276.937.400', 'D12.776.124.862.400', 'D12.776.467.937.400', 'D23.529.937.400'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.136.500', 'B01.050.150.900.649.313.992.635.505.500.800'], ['C05.116.198.579', 'C18.452.104.579'], ['D12.644.276.374.750.562... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Fundamental and clinical studies of cefuroxime, a new cephalosporin antibiotic, in pediatric field (author's transl)]. | A series of studies on cefuroxime (CXM) were carried out and the following results were obtained. 1) Most of MICs to recent clinical isolates of Group A hemolytic Streptococcus were less than 0.0125 micrograms/ml. 2) A single intravenous bolus dose of 36.5 mg/kg of CXM was given to two children, and the peak blood leve... | ['Bacterial Infections', 'Bronchitis', 'Cefuroxime', 'Cephalosporins', 'Child', 'Child, Preschool', 'Drug Resistance, Microbial', 'Female', 'Humans', 'Infant', 'Male', 'Pneumonia', 'Urinary Tract Infections'] | 513,297 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Volume-regulated arginine vasopressin release in conscious dogs. Evidence for dopaminergic or opioid modulation? | The possibility of a dopaminergic and/or opioid modulation of the volume-regulated release of AVP was investigated in conscious dogs. Either bromocriptine, 10 micrograms/kg body weight po, or naloxone, 0.1 mg/kg body weight iv, was administered prior to induction of nonhypotensive hypovolemia. Volume contraction of 15 ... | ['Animals', 'Arginine Vasopressin', 'Blood Pressure', 'Blood Volume', 'Bromocriptine', 'Dogs', 'Female', 'Heart Rate', 'Humans', 'Male', 'Naloxone', 'Receptors, Dopamine', 'Receptors, Opioid'] | 2,842,992 | [['B01.050'], ['D06.472.699.631.692.781.100', 'D12.644.400.900.100', 'D12.644.456.925.100', 'D12.644.548.691.692.781.100', 'D12.776.631.650.937.100'], ['E01.370.600.875.249', 'G09.330.380.076'], ['G09.188.130', 'G09.330.380.092'], ['D03.132.327.412.100', 'D03.633.400.439.131', 'D03.633.400.562.100'], ['B01.050.150.900.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Hydrazide derivatives with biologically active 1,2,4-triazole support]. | This study presents the synthesis of ten new hydrazides with 1,2,4-triazole support. The structures of the obtained compounds were elucidates by means of the elemental analysis data as well as by IR spectral measurements. The antimicrobial and antifungal actions of this derivates are also tested. The results show that ... | ['Anti-Bacterial Agents', 'Anti-Infective Agents', 'Bacteria', 'Candida albicans', 'Microbial Sensitivity Tests', 'Structure-Activity Relationship', 'Triazoles'] | 10,756,832 | [['D27.505.954.122.085'], ['D27.505.954.122'], ['B03'], ['B01.300.107.795.095.326', 'B01.300.381.147.326', 'B01.300.930.176.326'], ['E01.370.225.875.595', 'E05.200.875.595', 'E05.337.550.400'], ['G02.111.830', 'G07.690.773.997'], ['D03.383.129.799']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Moral distress in nurses providing direct care on inpatient oncology units. | Moral distress is defined as knowing the right thing to do when policy constraints do not allow for appropriate choices. The purpose of the current study was to explore the existence of moral distress in oncology nurses with a cross-sectional survey completed by nurses working on inpatient units at a midwestern cancer ... | ['Adult', 'Aged', 'Humans', 'Inpatients', 'Middle Aged', 'Midwestern United States', 'Morals', 'Neoplasms', 'Nursing Staff, Hospital', 'Oncology Nursing', 'Stress, Psychological', 'Young Adult'] | 25,253,107 | [['M01.060.116'], ['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.643.470'], ['M01.060.116.630'], ['Z01.107.567.875.510'], ['F01.829.500', 'K01.752.566'], ['C04'], ['M01.526.485.680.490', 'M01.526.485.740.523', 'N02.360.680.490', 'N02.360.740.523'], ['H02.478.676.605', 'N02.421.533.600'], ['... | ['Named Groups [M]', 'Organisms [B]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Humanities [K]', 'Diseases [C]', 'Health Care [N]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
Anatomical specificity and time-dependence of chlordiazepoxide-induced spatial memory impairments. | Injection of the benzodiazepine (BDZ) chlordiazepoxide (CDP) into the medial septum (MS) produced a dose-dependent retrograde working memory deficit in a delayed non-match-to-sample radial-arm maze task. CDP (30 nmol; 10 micrograms) decreased the number of correct choices and increased the number of errors without alte... | ['Animals', 'Brain', 'Brain Mapping', 'Chlordiazepoxide', 'Dominance, Cerebral', 'Gyrus Cinguli', 'Male', 'Maze Learning', 'Mental Recall', 'Orientation', 'Rats', 'Rats, Sprague-Dawley', 'Retention, Psychology', 'Septum Pellucidum', 'Substantia Innominata'] | 7,662,154 | [['B01.050'], ['A08.186.211'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['D03.633.100.079.080.150'], ['F02.830.297', 'G11.561.225'], ['A08.186.211.180.590.500', 'A08.186.211.200.885.287.500.382.500'], ['F02.463.425.874.500'], ['F02.463.425.540.641'], ['F01.058.577', 'F02.830.606'], ['B... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Overexpression of cancer susceptibility candidate 2 inhibited progression of hepatocellular carcinoma cells. | OBJECTIVE: Our study was aimed to investigate the effect of cancer susceptibility candidate 2 (CASC2) on the proliferation, cell cycle, apoptosis, and metastasis of hepatocellular carcinoma (HCC) cells.METHODS: CASC2 expression in tumor tissues and HCC cells was tested by quantitative real-time polymerase chain reactio... | ['Animals', 'Apoptosis', 'Carcinoma, Hepatocellular', 'Cell Cycle Checkpoints', 'Cell Movement', 'Cell Proliferation', 'Female', 'Gene Expression Regulation, Neoplastic', 'Hep G2 Cells', 'Humans', 'Liver Neoplasms', 'Male', 'Mice, Nude', 'Middle Aged', 'Neoplasm Invasiveness', 'Proto-Oncogene Proteins c-akt', 'Signal T... | 30,362,539 | [['B01.050'], ['G04.146.954.035'], ['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['G04.144.109'], ['G04.198', 'G07.568.500.180'], ['G04.161.750', 'G07.345.249.410.750'], ['G05.308.370'], ['A11.251.860.180.432', 'A11.436.348.500'], ['B01.050.150.900.649.313.988.400.112.400.400... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Effect of aspiration of coronary thrombus upon prognosis of patients in primary percutaneous coronary intervention]. | OBJECTIVE: To evaluate the effect of aspiration of coronary thrombus upon the outcome of in-hospital primary percutaneous coronary intervention (PCI) in acute myocardial infarction (AMI) patients.METHODS: A total of 202 AMI patients undergoing primary PCI and receiving aspiration thrombectomy catheter during from Decem... | ['Aged', 'Angioplasty, Balloon, Coronary', 'Coronary Thrombosis', 'Female', 'Humans', 'Male', 'Middle Aged', 'Prognosis', 'Suction'] | 20,627,015 | [['M01.060.116.100'], ['E02.148.050.060.100', 'E04.100.376.719.100', 'E04.100.814.529.124.060.100', 'E04.100.814.529.968.050', 'E04.502.382.124.060.100', 'E04.502.382.968.050', 'E04.928.220.520.100', 'E05.157.016.060.100'], ['C14.280.647.250.290', 'C14.907.355.830.220', 'C14.907.585.250.290'], ['B01.050.150.900.649.313... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Home infusions of biphosphonate in cancer patients: a prospective study. | The objective of the study was to determine outcome and satisfaction of cancer patients treated by home-infusions of biphosphonates. 107 patients entered the study and 97 of them chose to receive infusions of zoledronic acid (Z) in the home setting. Patient satisfaction and quality of care (QoC) were assessed by a 22-i... | ['Bone Density Conservation Agents', 'Bone Neoplasms', 'Diphosphonates', 'Female', 'Home Infusion Therapy', 'Humans', 'Imidazoles', 'Infusions, Intravenous', 'Male', 'Middle Aged', 'Pain', 'Patient Acceptance of Health Care', 'Patient Compliance', 'Patient Satisfaction', 'Prospective Studies', 'Treatment Outcome', 'Zol... | 16,736,892 | [['D27.505.696.242'], ['C04.588.149', 'C05.116.231'], ['D02.705.429.500'], ['E02.319.444', 'N02.421.143.524.436'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.383.129.308'], ['E02.319.267.082.500', 'E02.319.267.510.590'], ['M01.060.116.630'], ['C23.888.592.612', 'F02.830.816.444', 'G11.561.790.444'], ['F01.1... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Differential induction of TLR3-dependent innate immune signaling by closely related parasite species. | The closely related protozoan parasites Toxoplasma gondii and Neospora caninum display similar life cycles, subcellular ultrastructure, invasion mechanisms, metabolic pathways, and genome organization, but differ in their host range and disease pathogenesis. Type II (ã) interferon has long been known to be the major me... | ['Animals', 'Cells, Cultured', 'Coccidiosis', 'Host-Parasite Interactions', 'Humans', 'Immunity, Innate', 'Interferon Type I', 'Macrophages', 'Mice', 'Neospora', 'Toll-Like Receptor 3', 'Toxoplasma', 'Toxoplasmosis'] | 24,505,488 | [['B01.050'], ['A11.251'], ['C01.610.752.250'], ['G16.527.200.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G12.450.564'], ['D12.644.276.374.440.890', 'D12.776.467.374.440.890', 'D23.529.374.440.890'], ['A11.329.372', 'A11.627.482', 'A11.733.397', 'A15.382.670.522', 'A15.382.680.397'], ['B01.050.150.900.649... | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Graduate Medical Education Initiatives to Develop the Physician Workforce in Rural Wisconsin. | The physician shortage is an increasing concern across the nation. Wisconsin is seeing this shortage grow even more prominently in rural counties. In order to prepare a sufficient rural physician workforce, several state-funded programs are collaborating to monitor the number of rural graduate medical education (GME) o... | ['Education, Medical, Graduate', 'Humans', 'Physicians', 'Rural Health', 'Rural Health Services', 'Wisconsin', 'Workforce'] | 30,674,096 | [['I02.358.337.350', 'I02.358.399.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.526.485.810', 'N02.360.810'], ['N01.400.548.750'], ['N02.421.816'], ['Z01.107.567.875.350.900', 'Z01.107.567.875.510.900'], ['N04.452.525']] | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Named Groups [M]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
The calcineurin inhibitor RCAN1 is involved in cultured macrophage and in vivo immune response. | Studies on the role of regulator of calcineurin 1 (RCAN1) in immunity are limited, but have demonstrated an involvement in T-lymphocyte function. Here, we expand these studies to macrophages and in vivo infection. The treatment of RAW and primary mouse macrophages with lipopolysaccharide from Escherichia coli strongly ... | ['Animals', 'Calcineurin Inhibitors', 'Calcium-Binding Proteins', 'Cells, Cultured', 'Cytokines', 'Escherichia coli', 'Female', 'Francisella tularensis', 'Intracellular Signaling Peptides and Proteins', 'Lipopolysaccharides', 'Macrophages', 'Male', 'Mice', 'Mice, Knockout', 'Muscle Proteins', 'Peptidoglycan', 'Staphylo... | 21,073,546 | [['B01.050'], ['D27.505.519.389.174'], ['D12.776.157.125'], ['A11.251'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['B03.440.400.425.340.590', 'B03.660.250.200.750'], ['D12.644.360', 'D12.776.476'], ['D09.400.500', 'D09.698.718.450', 'D10.494', 'D23.0... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Testicular torsion in adults: plea for its consideration early in clinical evaluation of acute scrotum. | A case of a thirty-eight-year-old man with acute scrotum is presented. Past history of transient episodes of testicular pain, negative findings on urinalysis, and lack of symptomatic relief despite antibiotic therapy plus a high index of suspicion helped establish the correct diagnosis of testicular torsion. A long del... | ['Acute Disease', 'Adult', 'Genital Diseases, Male', 'Humans', 'Infarction', 'Male', 'Scrotum', 'Spermatic Cord Torsion', 'Testis', 'Time Factors'] | 898,456 | [['C23.550.291.125'], ['M01.060.116'], ['C12.294'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.513.355', 'C23.550.717.489'], ['A05.360.444.661'], ['C12.294.693'], ['A05.360.444.849', 'A05.360.576.782', 'A06.300.312.782'], ['G01.910.857']] | ['Diseases [C]', 'Named Groups [M]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Human hair follicle and interfollicular keratinocyte reactivity to mouse HPV16-transformed cells: an in vitro study. | The role of stem cells in cancer formation and spreading has been established. As with normal tissue, the cancer stem cells need a special microenvironment to support their growth. This microenvironment may be represented by the tumor stroma. One of the possible ways of tumor stromal formation is the epithelial-mesench... | ['3T3 Cells', 'Animals', 'Cell Size', 'Cell Transformation, Neoplastic', 'Fibroblasts', 'Hair Follicle', 'Human papillomavirus 16', 'Humans', 'Keratin-8', 'Keratinocytes', 'Mice', 'Mice, Inbred C57BL', 'Neoplasms', 'Phenotype', 'Stromal Cells', 'Vimentin'] | 18,575,721 | [['A11.251.210.100', 'A11.329.228.100'], ['B01.050'], ['G04.325'], ['C04.697.098.500', 'C23.550.727.098.500'], ['A11.329.228'], ['A10.272.497.500', 'A17.360.710', 'A17.815.250.500'], ['B04.280.210.655.050.616', 'B04.613.204.655.050.616'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D05.750.078.593.450.600.800', ... | ['Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Iron release from haemosiderin and production of iron-catalysed hydroxyl radicals in vitro. | Isolated haemosiderin contained iron and nitrogen in a weight ratio of 6.75, with phosphorus and no detectable haem. Considerably more iron was released from haemosiderin under acidic conditions than under neutral conditions in the presence of ascorbate, nitrilotriacetate or dithionite. Unlike the situation with ascorb... | ['Chelating Agents', 'Cyclic N-Oxides', 'Electron Spin Resonance Spectroscopy', 'Free Radicals', 'Hemosiderin', 'Hydroxides', 'Iron', 'Microscopy, Electron', 'Oxidation-Reduction', 'Spin Labels'] | 2,833,249 | [['D27.505.519.914.500', 'D27.720.832.500'], ['D03.661.243'], ['E05.196.867.519.274'], ['D01.339', 'D02.389'], ['D12.776.556.526'], ['D01.045.250', 'D01.248.497.158.459'], ['D01.268.556.412', 'D01.268.956.287', 'D01.552.544.412'], ['E01.370.350.515.402', 'E05.595.402'], ['G02.700', 'G03.295.531'], ['D02.389.678']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
TGF-beta suppresses EGF-induced MAPK signaling and proliferation in asthmatic epithelial cells. | Epithelial damage is an important pathophysiologic feature of asthma. Bronchial epithelium damage results in release of growth factors such as transforming growth factor (TGF)-beta(1) that may affect epithelial cell proliferation. The objective of our study is to evaluate the importance of TGF-beta(1) in regulating epi... | ['Asthma', 'Base Sequence', 'Blotting, Western', 'Case-Control Studies', 'Cell Proliferation', 'DNA Primers', 'Enzyme-Linked Immunosorbent Assay', 'Epidermal Growth Factor', 'Epithelial Cells', 'Humans', 'MAP Kinase Signaling System', 'Reverse Transcriptase Polymerase Chain Reaction', 'Transforming Growth Factor beta'] | 17,872,498 | [['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['G04.... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
The role of ubiquitin in neurotrophin receptor signalling and sorting. | NGF (nerve growth factor) binding to TrkA (tropomyosin receptor kinase A) induces dimerization, autophosphorylation and internalization of the receptor to signalling vesicles for delivery of differentiation signals. TrkA interacts with p75 receptor through the p62-TRAF-6 (tumour-necrosis-factor-receptor-associated fact... | ['Animals', 'Brain-Derived Neurotrophic Factor', 'Protein Kinase C', 'Receptor, trkA', 'Receptors, Nerve Growth Factor', 'Signal Transduction', 'Ubiquitin'] | 17,052,191 | [['B01.050'], ['D12.644.276.860.100', 'D12.776.467.860.100', 'D12.776.631.600.100', 'D23.529.850.100'], ['D08.811.913.696.620.682.700.725'], ['D08.811.913.696.620.682.725.400.660', 'D12.776.543.750.630.496', 'D12.776.543.750.750.400.550.550'], ['D12.776.543.750.750.400.550'], ['G02.111.820', 'G04.835'], ['D12.776.947.5... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Clinical and radiological findings in Brazilian patients with mucolipidosis types II/III. | OBJECTIVE: The present study aims to provide orientation for clinicians and radiologists to recognize the most prevalent findings leading to diagnosis in mucolipidosis from a description of the natural history of five Brazilian cases.MATERIALS AND METHODS: We conducted an observational and retrospective study of five p... | ['Adolescent', 'Adult', 'Brazil', 'Child', 'Child, Preschool', 'Female', 'Humans', 'Infant', 'Male', 'Mucolipidoses', 'Radiography', 'Retrospective Studies', 'Young Adult'] | 30,712,120 | [['M01.060.057'], ['M01.060.116'], ['Z01.107.757.176'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['C05.116.198.371', 'C10.228.140.163.100.435.590', 'C16.320.565.189.435.590', 'C16.320.565.202.670', 'C16.320.565.595.554.590', 'C18.452.132.100.435.590', 'C18.... | ['Named Groups [M]', 'Geographicals [Z]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Ginseng-Derived Panaxadiol Saponins Promote Hematopoiesis Recovery in Cyclophosphamide-Induced Myelosuppressive Mice: Potential Novel Treatment of Chemotherapy-Induced Cytopenias. | OBJECTIVE: To investigate the potential efficacy of panaxadiol saponins component (PDS-C), a biologically active fraction isolated from total ginsenosides, to reverse chemotherapy-induced myelosuppression and pancytopenia caused by cyclophamide (CTX).METHODS: Mice with myelosuppression induced by CTX were treated with ... | ['Animals', 'Antineoplastic Agents', 'Cell Proliferation', 'Cyclophosphamide', 'Extracellular Signal-Regulated MAP Kinases', 'GATA1 Transcription Factor', 'Ginsenosides', 'Hematopoiesis', 'Mice', 'Mitogen-Activated Protein Kinase Kinases', 'Myeloid Cells', 'Panax', 'Pancytopenia', 'Phosphorylation', 'Proto-Oncogene Pro... | 28,432,529 | [['B01.050'], ['D27.505.954.248'], ['G04.161.750', 'G07.345.249.410.750'], ['D02.455.526.728.650.730.243', 'D02.705.672.500.243'], ['D08.811.913.696.620.682.700.567.249', 'D12.644.360.450.169', 'D12.776.476.450.169'], ['D12.776.260.235.500', 'D12.776.260.257.100', 'D12.776.930.216.500', 'D12.776.930.314.100'], ['D02.45... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Improved glycaemic control with dipeptidyl peptidase-4 inhibition in patients with type 2 diabetes: vildagliptin (LAF237) dose response. | OBJECTIVE: A novel treatment option for diabetic patients is the enhancement of incretin hormone activity by inhibition of the enzyme dipeptidyl peptidase-4 (DPP-4). This study was designed to establish a dose of the DPP-4-inhibitor vildagliptin (LAF237) that was effective in reducing HbA1c levels and was safe and well... | ['Adamantane', 'Adenosine Deaminase Inhibitors', 'Adult', 'Aged', 'Blood Glucose', 'Diabetes Mellitus, Type 2', 'Dipeptidyl Peptidase 4', 'Dose-Response Relationship, Drug', 'Double-Blind Method', 'Drug Administration Schedule', 'Female', 'Glycated Hemoglobin A', 'Glycoproteins', 'Humans', 'Hypoglycemic Agents', 'Insul... | 16,219,012 | [['D02.455.426.100.050', 'D02.455.426.392.368.075'], ['D27.505.519.389.092'], ['M01.060.116'], ['M01.060.116.100'], ['D09.947.875.359.448.500'], ['C18.452.394.750.149', 'C19.246.300'], ['D08.811.277.656.350.350.126', 'D08.811.277.656.959.250', 'D23.050.301.264.894.160', 'D23.101.100.894.160'], ['G07.690.773.875', 'G07.... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Reflecting on the action or its outcome: behavior representation level modulates high level outcome priming effects on self-agency experiences. | Recent research suggests that one can have the feeling of being the cause of an action's outcome, even in the absence of a prior intention to act. That is, experienced self-agency over behavior increases when outcome representations are primed outside of awareness, prior to executing the action and observing the result... | ['Awareness', 'Humans', 'Intention', 'Internal-External Control', 'Photic Stimulation', 'Psychomotor Performance', 'Reaction Time', 'Self Efficacy', 'Subliminal Stimulation', 'Unconscious, Psychology'] | 20,071,196 | [['F02.463.188.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.658.650', 'F02.463.306'], ['F01.829.379'], ['E05.723.729'], ['F02.808', 'G11.427.700', 'G11.561.660'], ['E05.796.817', 'F02.830.650', 'F04.669.817', 'G11.561.677'], ['F01.752.747.792.700'], ['F02.463.593.710.750'], ['F01.752.747.930', 'F02.739... | ['Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The heterozygous N291S mutation in the lipoprotein lipase gene impairs whole-body insulin sensitivity and affects a distinct set of plasma metabolites in humans. | BACKGROUND: Mutations in the lipoprotein lipase gene causing decreased lipoprotein lipase activity are associated with surrogate markers of insulin resistance and the metabolic syndrome in humans.OBJECTIVE: We investigated the hypothesis that a heterozygous lipoprotein lipase mutation (N291S) induces whole-body insulin... | ['Female', 'Heterozygote', 'Humans', 'Insulin Resistance', 'Lipoprotein Lipase', 'Male', 'Middle Aged', 'Mutation', 'Plasma'] | 28,502,509 | [['G05.380.383'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C18.452.394.968.500', 'G07.690.773.984.617'], ['D08.811.277.352.100.430'], ['M01.060.116.630'], ['G05.365.590'], ['A12.207.152.693', 'A12.207.270.695', 'A15.145.693']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Named Groups [M]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Amazonian freshwater habitats experiencing environmental and socioeconomic threats affecting subsistence fisheries. | Matching the trend seen among the major large rivers of the globe, the Amazon River and its tributaries are facing aquatic ecosystem disruption that is affecting freshwater habitats and their associated biodiversity, including trends for decline in fishery resources. The Amazon's aquatic ecosystems, linked natural reso... | ['Animals', 'Biodiversity', 'Brazil', 'Conservation of Natural Resources', 'Ecosystem', 'Fisheries', 'Fishes', 'Fresh Water', 'Humans', 'Turtles'] | 25,572,836 | [['B01.050'], ['G16.500.275.157.049', 'N06.230.124.049'], ['Z01.107.757.176'], ['J01.256', 'N06.230.080'], ['G16.500.275.157', 'N06.230.124'], ['J01.040.168.300', 'J03.540.280'], ['B01.050.150.900.493'], ['G16.500.275.280', 'N06.230.232'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.833.848']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Geographicals [Z]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
Cavitation dynamics and directional microbubble ejection induced by intense femtosecond laser pulses in liquids. | We study cavitation dynamics when focusing ring-shaped femtosecond laser beams in water. This focusing geometry reduces detrimental nonlinear beam distortions and enhances energy deposition within the medium, localized at the focal spot. We observe remarkable postcollapse dynamics of elongated cavitation bubbles with h... | ['Computer Simulation', 'Gases', 'Lasers', 'Microbubbles', 'Models, Chemical', 'Rheology', 'Solutions'] | 23,031,010 | [['L01.224.160'], ['D01.362'], ['E07.632.490', 'E07.710.520'], ['E07.553'], ['E05.599.495'], ['E05.830', 'H01.671.808'], ['D26.776']] | ['Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
MRI-based motion correction of thoracic PET: initial comparison of acquisition protocols and correction strategies suitable for simultaneous PET/MRI systems. | OBJECTIVES: Magnetic resonance imaging (MRI) acquired on equipment capable of simultaneous MRI and positron emission tomography (PET) could potentially provide the gold standard method for motion correction of PET. To assess the latter, in this study we compared fast 2D and 3D MRI of the torso and used deformation para... | ['Algorithms', 'Artifacts', 'Computer Simulation', 'Humans', 'Image Processing, Computer-Assisted', 'Imaging, Three-Dimensional', 'Magnetic Resonance Imaging', 'Models, Statistical', 'Motion', 'Pilot Projects', 'Positron-Emission Tomography', 'Respiration', 'Thorax', 'Time Factors', 'Whole Body Imaging'] | 21,938,440 | [['G17.035', 'L01.224.050'], ['E05.047'], ['L01.224.160'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['E01.370.350.400', 'L01.224.308.410'], ['E01.370.350.825.500'], ['E05.318.740.500', 'E05.599.835', 'N05.715.360.750.530', 'N06.850.520.830.500'], ['G01.482'], ['E05.318.372.750', 'E05.337.737', ... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Mechanisms of telomerase inhibition by oxidized and therapeutic dNTPs. | Telomerase is a specialized reverse transcriptase that adds GGTTAG repeats to chromosome ends and is upregulated in most human cancers to enable limitless proliferation. Here, we uncover two distinct mechanisms by which naturally occurring oxidized dNTPs and therapeutic dNTPs inhibit telomerase-mediated telomere elonga... | ['Deoxyadenine Nucleotides', 'Deoxyguanine Nucleotides', 'Enzyme Inhibitors', 'Humans', 'Kinetics', 'Models, Molecular', 'Oxidation-Reduction', 'Telomerase', 'Telomere'] | 33,082,336 | [['D03.633.100.759.646.138.410', 'D13.695.201.100', 'D13.695.667.138.410'], ['D03.633.100.759.646.454.200', 'D13.695.201.175', 'D13.695.667.454.200'], ['D27.505.519.389'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.374.661', 'G02.111.490'], ['E05.599.595'], ['G02.700', 'G03.295.531'], ['D08.811.913.696.445.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Development, validation and clinical application of a LC-MS/MS method for the simultaneous quantification of hydroxychloroquine and its active metabolites in human whole blood. | A rapid, sensitive and specific method using liquid chromatography coupled to tandem mass spectrometry was developed for the simultaneous quantification of hydroxychloroquine (HCQ) and its three major metabolites in human whole blood. The assay, using a sample volume of 100ìL, was linear in a dynamic 25-2000ng/mL range... | ['Adult', 'Antimalarials', 'Biotransformation', 'Calibration', 'Chromatography, Liquid', 'Drug Monitoring', 'Drug Stability', 'Female', 'Humans', 'Hydroxychloroquine', 'Linear Models', 'Poisoning', 'Reference Standards', 'Reproducibility of Results', 'Suicide, Attempted', 'Tandem Mass Spectrometry', 'Time Factors'] | 25,165,008 | [['M01.060.116'], ['D27.505.954.122.250.100.085'], ['G03.171', 'G03.787.225', 'G07.690.725.225'], ['E05.978.155'], ['E05.196.181.400'], ['E01.370.520.200'], ['E05.916.330'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.633.100.810.050.180.350'], ['E05.318.740.500.500', 'E05.318.740.750.425', 'E05.599.835.750'... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
[Therapeutic problems of autonomous adenoma of the thryroid (author's transl)]. | Radioiodine therapy and surgical enucleation as a functionally legitimate operation are adequate methods of treatment for the autonomous adenoma of the thyroid. With reference to a series of our own patients, the making of the indication, the operation technique and the carrying out of radioiodine therapy are commented... | ['Adenoma', 'Adolescent', 'Adult', 'Aged', 'Child', 'Female', 'Humans', 'Iodine Radioisotopes', 'Male', 'Methods', 'Middle Aged', 'Postoperative Care', 'Preoperative Care', 'Radiotherapy Dosage', 'Thyroid Neoplasms'] | 817,177 | [['C04.557.470.035'], ['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.406'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.268.380.400.500.496', 'D01.496.448.496', 'D01.496.749.474'], ['E05.581'], ['M01.060.116.630'], ['E02.760.731.700', 'E04.604.500', 'N02.421.585.722.700'], ['E02.760.795', '... | ['Diseases [C]', 'Named Groups [M]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Is it all task-specific? The role of binary responses, verbal mediation, and saliency for eliciting language-space associations. | Associations between language and space are of central interest for grounded models of language comprehension. Various studies show that reading words such as bird or shoe results in faster responses toward the typical location of the corresponding entity (e.g., after bird, upward responses are faster than downward res... | ['Adult', 'Analysis of Variance', 'Association', 'Comprehension', 'Female', 'Humans', 'Language', 'Male', 'Reaction Time', 'Reading', 'Space Perception', 'Stroop Test', 'Vocabulary', 'Young Adult'] | 27,504,680 | [['M01.060.116'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['F02.463.425.069', 'F04.754.720.346'], ['F02.463.188.357'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.209.399', 'L01.559'], ['E05.796.817', 'F02.830.650', 'F04.669.817', 'G11.561.677'], ['L01.559.423.557'], ['F02.463.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Information Science [L]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
The role of peer stress and pubertal timing on symptoms of psychopathology during early adolescence. | Stress is known to amplify the link between pubertal timing and psychopathology. However, few studies have examined the role of peer stress as a context for this link. The present study examined the interaction between perceived pubertal timing and peer stress on symptoms of psychopathology in early adolescence. The sa... | ['Adolescent', 'Age Factors', 'Aggression', 'Anxiety', 'Child', 'Cross-Sectional Studies', 'Depression', 'Female', 'Humans', 'Linear Models', 'Male', 'Peer Group', 'Puberty', 'Self Report', 'Sex Factors', 'Social Desirability', 'Stress, Psychological'] | 21,170,672 | [['M01.060.057'], ['N05.715.350.075', 'N06.850.490.250'], ['F01.145.126.125', 'F01.145.813.045'], ['F01.470.132'], ['M01.060.406'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['F01.145.126.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.500', 'E05.318.740.75... | ['Named Groups [M]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Physical activity and functional capacity measurement in women: a report from the NHLBI-sponsored WISE study. | Physical activity and functional capacity have not been assessed by questionnaire for criterion validity in women. We wished to evaluate the ability of a physical activity and a functional capacity assessment questionnaire to predict functional capacity measured by treadmill exercise stress testing, as well as correlat... | ['Activities of Daily Living', 'Aged', 'Coronary Angiography', 'Coronary Disease', 'Cross-Sectional Studies', 'Exercise Test', 'Female', 'Health Status', 'Health Surveys', 'Humans', 'Middle Aged', 'Myocardial Ischemia', 'Physical Fitness', 'Predictive Value of Tests', 'Risk Assessment', 'Surveys and Questionnaires'] | 11,025,869 | [['E02.760.169.063.500.067', 'E02.831.067', 'I03.050', 'N02.421.784.110'], ['M01.060.116.100'], ['E01.370.350.130.625', 'E01.370.350.700.060.200', 'E01.370.370.050.200', 'E01.370.370.380.200'], ['C14.280.647.250', 'C14.907.585.250'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['E01.3... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Successful treatment of a viable cervical pregnancy with methotrexate. | Cervical pregnancies usually result in early spontaneous abortion, and most forms of conservative treatment are not recommended beyond 8 weeks' gestation. We present a case of a 9-week viable cervical pregnancy that is successfully managed with methotrexate. | ['Adult', 'Cervix Uteri', 'Chorionic Gonadotropin', 'Curettage', 'Female', 'Humans', 'Methotrexate', 'Pregnancy', 'Pregnancy, Ectopic', 'Ultrasonography'] | 2,686,443 | [['M01.060.116'], ['A05.360.319.679.256'], ['D06.472.699.322.326', 'D06.472.699.649.367', 'D12.644.548.726.367', 'D12.776.780.400'], ['E04.157'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.633.100.733.631.192.500'], ['G08.686.784.769'], ['C13.703.733'], ['E01.370.350.850']] | ['Named Groups [M]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Validation of self-administered nasal swabs and postage for the isolation of Staphylococcus aureus. | Staphylococcus aureus carriers are at higher risk of S. aureus infection and are a reservoir for transmission to others. Detection of nasal S. aureus carriage is important for both targeted decolonization and epidemiological studies. Self-administered nasal swabbing has been reported previously, but the effects of post... | ['Adolescent', 'Adult', 'Aged', 'Carrier State', 'Cohort Studies', 'Female', 'Healthy Volunteers', 'Humans', 'Longitudinal Studies', 'Male', 'Middle Aged', 'Nose', 'Postal Service', 'Self Administration', 'Sensitivity and Specificity', 'Specimen Handling', 'Staphylococcal Infections', 'Staphylococcus aureus', 'Young Ad... | 27,902,394 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['N06.850.520.169'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['M01.774.500', 'M01.955.236'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.500.750.500', 'N05.715.360.330.500.750.500', 'N06.850.520.450.500.750... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
The effects of norethindrone on the mullerian ducts of the American alligator. | Norethindrone, a reported aromatase inhibitor, has been used to examine the role of estrogens in the unilateral regression of the mullerian ducts that occurs in female chick embryos. The mullerian ducts are embryonic oviducts that regress in most male vertebrates under the influence of the testicular hormone, mullerian... | ['Alligators and Crocodiles', 'Animals', 'Estradiol', 'Female', 'Hypertrophy', 'Mullerian Ducts', 'Norethindrone'] | 1,783,275 | [['B01.050.150.900.833.100'], ['B01.050'], ['D04.210.500.365.415.248', 'D06.472.334.851.437.500'], ['C23.300.775'], ['A16.623'], ['D04.210.500.668.651.693.651']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Local direction of edge motion causes and abolishes the barberpole illusion. | The perceived direction of motion of a one-dimensional grating is measured in straight-edged rectangular and indented rectangular apertures. It is shown that the perceived direction of motion of the pattern is largely determined by the directions of motion at the edges, rather than by the aspect ratio or global shape o... | ['Humans', 'Motion Perception', 'Optical Illusions', 'Pattern Recognition, Visual', 'Time Factors'] | 8,273,299 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.593.932.567'], ['F02.463.593.446.659'], ['F02.463.593.524.500', 'F02.463.593.932.622'], ['G01.910.857']] | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cogeneration of biodiesel and nontoxic rapeseed meal from rapeseed through in-situ alkaline transesterification. | In-situ alkaline transesterification of rapeseed oil with methanol for the production of biodiesel and nontoxic rapeseed meal was carried out. Water removal from milled rapeseed by methanol washing was more effective than vacuum drying. The conversion rate of rapeseed oil into FAME was 92%, FAME mass was 8.81 g, glucos... | ['Alkalies', 'Biofuels', 'Brassica rapa', 'Esterification', 'Fatty Acids, Monounsaturated', 'Methanol', 'Plant Extracts', 'Plant Oils', 'Rapeseed Oil', 'Water'] | 23,196,215 | [['D01.045'], ['D20.147', 'N06.230.132.644.124'], ['B01.650.940.800.575.912.250.157.200.277'], ['G02.111.270', 'G02.607.250', 'G03.344'], ['D10.251.355.325'], ['D02.033.623'], ['D20.215.784.500', 'D26.667'], ['D10.627.700', 'D20.215.784.750'], ['D10.627.700.066', 'D20.215.784.750.066'], ['D01.045.250.875', 'D01.248.497... | ['Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[The study of ctxB and rstR variations of toxigenic Vibrio cholerae O1 El Tor strains isolated from 1961 to 2010 in China]. | OBJECTIVE: To understand the ctxB and rstR variations of toxigenic Vibrio cholerae (V.cholerae) O1 El Tor strains isolated from different provinces in China from 1961 to 2010.METHODS: All 385 toxigenic V.cholerae O1 El Tor strains were selected, which were isolated in China between year 1961 and 2010. ctxB gene was amp... | ['China', 'Cholera', 'Genotype', 'Molecular Epidemiology', 'Polymerase Chain Reaction', 'Vibrio cholerae', 'Vibrio cholerae O1'] | 25,219,433 | [['Z01.252.474.164'], ['C01.150.252.400.959.347'], ['G05.380'], ['E05.318.416', 'E05.393.522', 'H01.158.201.636.475.500', 'H01.158.273.343.595.475.500', 'H01.181.122.650.475.550', 'H02.403.720.500.300', 'N06.850.520.470'], ['E05.393.620.500'], ['B03.440.450.900.859.225', 'B03.660.250.830.830.100'], ['B03.440.450.900.85... | ['Geographicals [Z]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
Cubilin is expressed in rat and human glomerular podocytes. | BACKGROUND: The bulk of proteins filtered in the glomeruli are reabsorbed in the proximal tubule by endocytosis mediated by two multiligand receptors operating in concert, megalin and cubilin. Podocytes can also internalize protein and megalin; this was initially reported in rat proximal tubular and glomerular epitheli... | ['Animals', 'Base Sequence', 'Cell Line', 'Cell Membrane', 'DNA Primers', 'Endocytosis', 'Gene Expression', 'Humans', 'Immunohistochemistry', 'Male', 'Microscopy, Fluorescence', 'Microscopy, Immunoelectron', 'Podocytes', 'RNA, Messenger', 'Rats', 'Rats, Inbred Lew', 'Rats, Sprague-Dawley', 'Rats, Wistar', 'Receptors, C... | 22,337,902 | [['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A11.251.210'], ['A11.284.149'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['G04.417'], ['G05.297'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', ... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Increased calpain expression in activated glial and inflammatory cells in experimental allergic encephalomyelitis. | In demyelinating diseases such as multiple sclerosis (MS), myelin membrane structure is destabilized as myelin proteins are lost. Calcium-activated neutral proteinase (calpain) is believed to participate in myelin protein degradation because known calpain substrates [myelin basic protein (MBP); myelin-associated glycop... | ['Animals', 'Antibodies, Monoclonal', 'Calpain', 'Encephalomyelitis, Autoimmune, Experimental', 'Galactosylceramides', 'Glial Fibrillary Acidic Protein', 'Immunoenzyme Techniques', 'Inflammation', 'Multiple Sclerosis', 'Neuroglia', 'Rats', 'Rats, Inbred Lew', 'Spinal Cord'] | 9,576,959 | [['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D08.811.277.656.262.500.120', 'D08.811.277.656.300.200.120'], ['C10.114.703.300', 'C10.228.140.695.562.250', 'C10.314.350.250', 'C20.111.258.625.300', 'E05.598.500.500.500'], ['D02.065.313.250.450', 'D09.400.4... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[General practice management of obstructive sleep apnea in the Midi-Pyr?n?es]. | INTRODUCTION: Obstructive sleep apnoea syndrome (OSAS) is a significant public health problem. In the French care system general practitioners have an important role to play in its management especially in the field of early diagnosis.METHODS: The first part of this work is a descriptive case-control study looking at h... | ['Adult', 'Aged', 'Cardiovascular Diseases', 'Case-Control Studies', 'Clinical Competence', 'Continuous Positive Airway Pressure', 'Female', 'France', 'Humans', 'Male', 'Middle Aged', 'Physicians, Family', 'Sleep Apnea, Obstructive', 'Surveys and Questionnaires'] | 17,417,166 | [['M01.060.116'], ['M01.060.116.100'], ['C14'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['E02.041.625.790.259', 'E02.880.820.790.259'], ['Z01.542.286'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['M01.5... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
The cytochrome P450-catalyzed metabolism of levomepromazine: a phenothiazine neuroleptic with a wide spectrum of clinical application. | The aim of the present study was to identify cytochrome P450 isoenzymes (CYPs) involved in the 5-sulfoxidation and N-demethylation of the aliphatic-type phenothiazine neuroleptic levomepromazine in human liver. Experiments were performed in vitro using cDNA-expressed human CYP isoforms (Supersomes 1A2, 2A6, 2B6, 2C8, 2... | ['Antipsychotic Agents', 'Biocatalysis', 'Cytochrome P-450 Enzyme System', 'Humans', 'Inactivation, Metabolic', 'Isoenzymes', 'Kinetics', 'Liver', 'Methotrimeprazine', 'Microsomes, Liver', 'Substrate Specificity'] | 24,841,887 | [['D27.505.696.277.950.040', 'D27.505.954.427.210.950.040', 'D27.505.954.427.700.872.331'], ['G02.111.086', 'G02.130.500', 'G03.105'], ['D08.244.453', 'D08.811.682.690.708.170', 'D12.776.422.220.453'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G03.171.450', 'G03.787.225.450', 'G07.690.725.225.450'], ['D08.811.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Integration and expression of Bluetongue VP2 gene in somatic embryos of peanut through particle bombardment method. | After pre-culture and treatment of osmosis, zygotic embryos of peanut (Arachis hypogaea L.) were transformed via particle bombardment with a plasmid containing a Bluetongue VP2 gene (BTVP2) comprising neutralizing epitopes. Selection for Kanamycin resistant calluses and somatic embryos was initiated at 12th day post-bo... | ['Arachis', 'Blotting, Southern', 'Capsid Proteins', 'DNA, Plant', 'Epitopes', 'Gene Expression', 'Gene Transfer Techniques', 'Glucuronidase', 'Kanamycin', 'Plants, Genetically Modified', 'Plasmids', 'RNA, Messenger', 'RNA, Viral', 'Recombination, Genetic', 'Reverse Transcriptase Polymerase Chain Reaction', 'Seeds', 'T... | 16,513,222 | [['B01.650.940.800.575.912.250.401.077'], ['E05.196.401.114', 'E05.301.300.087', 'E05.601.150'], ['D12.776.964.970.600.550'], ['D13.444.308.435'], ['D23.050.550'], ['G05.297'], ['E05.393.350'], ['D08.811.277.450.426'], ['D09.408.051.476'], ['B01.650.520', 'B05.620.600'], ['G05.360.600'], ['D13.444.735.544'], ['D13.444.... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Differential presentation of endogenous and exogenous hepatitis B surface antigens influences priming of CD8(+) T cells in an epitope-specific manner. | Little is known about whether presentation of endogenous and exogenous hepatitis B virus (HBV) surface antigens on APCs targeted by vaccination and/or virus-harboring hepatocytes influences de novo priming of CD8(+) T cells. We showed that surface antigen-expressing transfectants exclusively display a K(b) /S190 epitop... | ['Animals', 'Antigen Presentation', 'Antigen-Presenting Cells', 'CD8-Positive T-Lymphocytes', 'Cell Line, Tumor', 'Epitopes, T-Lymphocyte', 'Female', 'H-2 Antigens', 'Hepatitis B Surface Antigens', 'Male', 'Mice', 'Mice, Inbred C57BL'] | 24,723,392 | [['B01.050'], ['G12.119', 'G12.450.050.400.070'], ['A11.066', 'A15.382.066'], ['A11.118.637.555.567.569.220', 'A15.145.229.637.555.567.569.220', 'A15.382.490.555.567.569.220'], ['A11.251.210.190', 'A11.251.860.180'], ['D23.050.550.402'], ['D23.050.301.500.100.350', 'D23.050.301.500.400.199', 'D23.050.705.552.100.350', ... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The Presence of Symptoms With Comorbid Conditions in Individuals With Multiple Sclerosis (MS). | Individuals with multiple sclerosis (MS) may experience symptoms that impact comorbid conditions and quality of life (QOL). There is some evidence that symptom severity may vary in certain common health conditions in this population. We aimed to examine symptom severity in light of comorbid conditions commonly seen in ... | ['Cross-Sectional Studies', 'Depression', 'Fatigue', 'Female', 'Humans', 'Internet', 'Male', 'Middle Aged', 'Multiple Sclerosis', 'Quality of Life', 'Severity of Illness Index', 'Surveys and Questionnaires'] | 26,122,788 | [['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['F01.145.126.350'], ['C23.888.369'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.230.110.500'], ['M01.060.116.630'], ['C10.114.375.500', 'C10.314.350.500', 'C20.111.258.250.500'], ['I01.800', 'K01.752.400.750', 'N06.850.505.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Organisms [B]', 'Information Science [L]', 'Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 0 |
Comparative chromosome painting of pronghorn (Antilocapra americana) and saola (Pseudoryx nghetinhensis) karyotypes with human and dromedary camel probes. | BACKGROUND: Pronghorn (Antilocapridae, 2n = 58) and saola (Bovidae, 2n = 50) are members of Pecora, a highly diversified group of even-toed hoofed mammals. Karyotypes of these species were not involved in chromosome painting studies despite their intriguing phylogenetic positions in Pecora.RESULTS: To trace the chromos... | ['Animals', 'Camelus', 'Chromosome Mapping', 'Chromosome Painting', 'DNA Probes', 'Evolution, Molecular', 'Humans', 'Karyotype', 'Male', 'Phylogeny', 'Ruminants'] | 24,923,361 | [['B01.050'], ['B01.050.150.900.649.313.500.190.180'], ['E05.393.183'], ['E01.370.225.500.620.670.325.350.125', 'E01.370.225.750.600.670.325.350.125', 'E05.200.500.620.670.325.350.125', 'E05.200.750.600.670.325.350.125', 'E05.393.285.350.125', 'E05.393.661.475.350.125'], ['D13.444.600.223', 'D27.505.259.750.600.223', '... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Effects of different subtypes of histamine receptors on proliferation and differentiation of murine colony forming unit granulocyte-macrophage and colony forming unit megakaryocyte. | OBJECTIVE: To investigate the function and characteristics of histamine receptors on the hemopoietic progenitor cells.METHODS: BDF1 mice (both male and female), inbred at our university, aged 8-12 weeks, weighing 20-24 g, were used in this study. Bone marrow cells were incubated for 1 hour at 37 degrees C with 2-AT (H1... | ['Animals', 'Bone Marrow Cells', 'Cell Differentiation', 'Cell Division', 'Cells, Cultured', 'Female', 'Granulocytes', 'Hematopoietic Stem Cells', 'Histamine Agonists', 'Impromidine', 'Macrophages', 'Male', 'Megakaryocytes', 'Mice', 'Mice, Inbred Strains', 'Receptors, Histamine H1', 'Receptors, Histamine H2', 'Thiazole... | 10,374,372 | [['B01.050'], ['A11.148', 'A15.378.316'], ['G04.152'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.251'], ['A11.118.637.415', 'A11.148.350', 'A11.627.340', 'A15.145.229.637.415', 'A15.378.316.340', 'A15.382.490.315'], ['A11.148.378', 'A11.872.378', 'A15.378.316.378'], ['D27.505.519.6... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Withdrawal phenomenon with the antiandrogen casodex. | Total androgen blockade with castration and antiandrogens has become the primary therapy in metastatic prostate carcinoma. Several reports have been published on the flutamide withdrawal syndrome with a favorable response in patients with progression of disease after lengthy remission while taking combined hormone ther... | ['Aged', 'Aged, 80 and over', 'Anilides', 'Antineoplastic Agents', 'Humans', 'Male', 'Nitriles', 'Prostate-Specific Antigen', 'Prostatic Neoplasms', 'Substance Withdrawal Syndrome', 'Tosyl Compounds'] | 7,531,785 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['D02.065.199', 'D02.092.146.113'], ['D27.505.954.248'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.626'], ['D08.811.277.656.300.760.442.750', 'D08.811.277.656.959.350.442.750', 'D12.776.866.249.500', 'D23.050.285.625', 'D23.101.140.625'], ['C04.588.945.440.770... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
AIDS-related primary cardiac lymphoma with right-sided heart failure and high-grade AV block: insights from magnetic resonance imaging. | A 44-year-old patient, with personal history of AIDS, was referred to our emergency unit with tachycardia and moderate signs of right-sided heart failure. The cardiac MRI study showed an impairment of the right ventricular free and inferior wall and the interventricular septum. The mass was characterized by notable het... | ['Adult', 'Antineoplastic Agents', 'Atrioventricular Block', 'Contrast Media', 'Defibrillators, Implantable', 'Fatal Outcome', 'Gadolinium', 'Heart Failure', 'Heart Neoplasms', 'Humans', 'Immunocompromised Host', 'Lymphoma, AIDS-Related', 'Magnetic Resonance Imaging', 'Male', 'Pacemaker, Artificial', 'Time Factors', 'T... | 23,830,566 | [['M01.060.116'], ['D27.505.954.248'], ['C14.280.067.558.230', 'C14.280.123.500.230', 'C23.550.073.425.062'], ['D27.505.259.500', 'D27.720.259'], ['E07.305.250.159.175', 'E07.305.250.319.175', 'E07.695.202.175'], ['E05.318.308.985.550.325', 'N01.224.935.698.201', 'N06.850.505.400.975.550.325', 'N06.850.520.308.985.550.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Salzmann's nodular corneal degeneration clinical characteristics and surgical outcomes. | PURPOSE: To characterize the clinical characteristics and surgical outcomes for Salzmann's nodular corneal degeneration (SNCD).METHODS: In this retrospective, noncomparative, observational case series, all patients coded with a diagnosis of SNCD between January 1, 1996, and April 30, 2002 were included. Cases whose cli... | ['Adolescent', 'Adult', 'Age Distribution', 'Aged', 'Aged, 80 and over', 'Child', 'Cornea', 'Corneal Dystrophies, Hereditary', 'Diagnosis, Differential', 'Female', 'Humans', 'Male', 'Middle Aged', 'Retrospective Studies', 'Sex Distribution', 'Vision Disorders'] | 16,331,034 | [['M01.060.057'], ['M01.060.116'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['M01.060.406'], ['A09.371.060.217'], ['C11.204.236', 'C11.270.162', 'C16.320.290.162'], ['E01.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.37... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Dietary Oily Fish Intake and Blood Pressure Levels: A Population-Based Study. | The effect of fish consumption on blood pressure is controversial. The authors measured blood pressure and calculated oily fish servings per week in 677 community-dwellers aged 40 years and older living in rural coastal Ecuador. Using regression models with linear splines, the authors evaluated whether dietary fish int... | ['Adult', 'Blood Pressure', 'Blood Pressure Determination', 'Dietary Fats, Unsaturated', 'Ecuador', 'Female', 'Fish Oils', 'Humans', 'Hypertension', 'Male', 'Middle Aged', 'Population Surveillance', 'Prevalence', 'Risk Assessment', 'Risk Factors', 'Rural Population'] | 26,395,549 | [['M01.060.116'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E01.370.370.140', 'E01.370.600.100'], ['D10.212.302.380', 'G07.203.300.375.400', 'J02.500.375.400'], ['Z01.107.757.362'], ['D10.627.430'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['M01.060.116.630'], ['E05.318.308.980.438.700', 'N... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Geographicals [Z]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
Access to advanced therapy medicinal products in the EU: where do we stand? | The European Union has a public health strategy and will generally ensure in all its policies and activities a "high level of human health protection". The new Regulation (EC) n 1394/2007 on advanced therapy medicinal products (ATMP), stems from this global policy and aims to harmonise access to the ATMP market. A real... | ['Cell Transplantation', 'European Union', 'Genetic Therapy', 'Health Policy', 'Health Services Accessibility', 'Humans', 'National Health Programs', 'Tissue Engineering'] | 21,870,592 | [['E02.095.147.500', 'E04.936.225'], ['I01.615.500.475'], ['E02.095.301', 'E05.393.420.301'], ['I01.655.500.608.400', 'I01.880.604.825.608.400', 'N03.623.500.608.428'], ['N04.590.374.350', 'N05.300.430'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.349.550'], ['E05.481.500.311.500', 'J01.293.069.249.500']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 |
Combined cardiac surgery and excision of a retrosternal thyroid mass: a case report. | Retrosternal thyroid mass with posterior mediastinal extension is an extremely rare phenomenon. We describe a combined thyroidectomy, aortic valve replacement, and coronary artery bypass graft surgery on a patient with an asymptomatic retrosternal thyroid mass. | ['Aged', 'Aortic Valve Stenosis', 'Coronary Artery Bypass', 'Coronary Disease', 'Diagnosis, Differential', 'Goiter, Nodular', 'Heart Valve Prosthesis Implantation', 'Humans', 'Male', 'Thyroidectomy', 'Tomography, X-Ray Computed'] | 16,684,062 | [['M01.060.116.100'], ['C14.280.484.048.750', 'C14.280.955.249'], ['E04.100.376.719.332', 'E04.100.814.868.750', 'E04.928.220.520.220'], ['C14.280.647.250', 'C14.907.585.250'], ['E01.171'], ['C19.874.283.501'], ['E04.100.376.485', 'E04.650.410', 'E04.928.220.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Hepatitis-B virus endemicity: heterogeneity, catastrophic dynamics and control. | Hepatitis-B virus infection is globally ubiquitous, but its distribution is very heterogeneous, with prevalence of serological markers in various nations ranging from less than 1% to more than 90%. We propose an explanation for this diversity using a mathematical model of hepatitis-B virus transmission dynamics that sh... | ['Carrier State', 'Hepatitis B', 'Humans', 'Prevalence'] | 11,329,065 | [['N06.850.520.169'], ['C01.221.250.500', 'C01.925.256.430.400', 'C01.925.440.435', 'C06.552.380.705.437'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.750', 'N01.224.935.597.750', 'N06.850.505.400.975.525.750', 'N06.850.520.308.985.525.750']] | ['Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
The Drosophila fork head factor directly controls larval salivary gland-specific expression of the glue protein gene Sgs3. | The Drosophila Fork head protein participates in salivary gland formation, since salivary glands are missing in fork head embryos. Here we show that the fork head encoded protein binds to an upstream regulatory region of the larval salivary gland glue protein gene Sgs3. Mobility shift assay in the presence of an anti-F... | ['Amino Acid Sequence', 'Animals', 'Base Sequence', 'Binding Sites', 'Bombyx', 'Chromosomes', 'DNA', 'DNA-Binding Proteins', 'Drosophila', 'Forkhead Transcription Factors', 'Gene Expression Regulation, Developmental', 'Glue Proteins, Drosophila', 'Larva', 'Male', 'Molecular Sequence Data', 'Nuclear Proteins', 'Rabbits'... | 8,710,511 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G02.111.570.120'], ['B01.050.500.131.617.720.500.500.937.650.100'], ['A11.284.187', 'A11.284.430.106.279.345.190', 'G05.360.162'], ['D13.444.308'], ['D12.776.260'], ['B01.050.500.131.617.720.500.500.75... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Results of a conservative treatment combining induction (neoadjuvant) and consolidation chemotherapy, hormonotherapy, and external and interstitial irradiation in 98 patients with locally advanced breast cancer (IIIA-IIIB). | Ninety-eight patients with locally advanced breast cancer (Stage IIIA-IIIB) were entered into a pilot study combining intensive induction (neoadjuvant) chemotherapy (VTMFAP) with or without hormonochemotherapy, external and interstitial radiotherapy, and consolidation chemotherapy with or without hormonochemotherapy. T... | ['Antineoplastic Combined Chemotherapy Protocols', 'Brachytherapy', 'Breast Neoplasms', 'Cobalt Radioisotopes', 'Combined Modality Therapy', 'Doxorubicin', 'Evaluation Studies as Topic', 'Fluorouracil', 'Humans', 'Iridium Radioisotopes', 'Methotrexate', 'Prednisone', 'Radioisotope Teletherapy', 'Remission Induction', '... | 3,129,176 | [['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['E02.815.150'], ['C04.588.180', 'C17.800.090.500'], ['D01.268.556.185.500.354', 'D01.268.956.155.500.354', 'D01.496.239.354', 'D01.496.749.256', 'D01.552.544.185.500.354'], ['E02.186'], ['D02.455.426.559.847.562.050.200.175', 'D04.615.562.050.200.175', 'D09.4... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Recovery and half-life of von Willebrand factor-cleaving protease after plasma therapy in patients with thrombotic thrombocytopenic purpura. | Plasma exchange using fresh-frozen plasma (FFP) for replacement was given to two brothers during a relapse of thrombotic thrombocytopenic purpura (TTP). A constitutional deficiency of von Willebrand factor(vWF)-cleaving protease had been previously established in both patients. No inhibitor of vWF-cleaving protease was... | ['ADAM Proteins', 'ADAMTS13 Protein', 'Adult', 'Enzyme Activation', 'Half-Life', 'Humans', 'Male', 'Metalloendopeptidases', 'Plasma Exchange', 'Platelet Count', 'Purpura, Thrombotic Thrombocytopenic', 'von Willebrand Factor'] | 10,348,715 | [['D08.811.277.656.675.374.102', 'D09.400.430.500', 'D12.776.395.033'], ['D08.811.277.656.675.374.102.500.813', 'D09.400.430.500.500.813', 'D12.776.395.033.500.813', 'D12.776.860.300.085.813'], ['M01.060.116'], ['G02.111.263', 'G03.328'], ['G01.910.405'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.277.6... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A new species of Ephemerellomyces from North America highlights its morphological plasticity and possible intergeneric similarities with other Harpellales. | During routine bioprospecting efforts in southern Idaho, we recovered a new species, Ephemerellomyces kandelii from nymphs of the mayfly genus Ephemerella (Ephemerellidae) in Dry Creek drainage, near Boise. This is the second observation of this monotypic genus since the description of Ephemerellomyces aquilonius from ... | ['Animals', 'Fungi', 'Idaho', 'Insecta', 'Microscopy', 'Spores, Fungal'] | 22,289,763 | [['B01.050'], ['B01.300'], ['Z01.107.567.875.560.380'], ['B01.050.500.131.617'], ['E01.370.350.515', 'E05.595', 'H01.671.617.562'], ['A11.870.710', 'A19.374.500', 'B05.775.710']] | ['Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 |
The effect of chlorpromazine on intracellular Ca2+ | Using Fura-2AM microfluorimetry, it was shown for the first time that neuroleptic chlorpromazine causes intracellular Ca2+ concentration increase in macrophages due to Ca2+ mobilization from intracellular Ca2+ stores and subsequent Ca2+ entry from the external medium. Chlorpromazine-induced Ca2+ entry is inhibited by L... | ['Animals', 'Calcium', 'Chlorpromazine', 'Dose-Response Relationship, Drug', 'Intracellular Space', 'Macrophages', 'Rats', 'Rats, Wistar'] | 28,726,103 | [['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D02.886.369.198', 'D03.633.300.783.198'], ['G07.690.773.875', 'G07.690.936.500'], ['A10.082.750', 'A11.284.430'], ['A11.329.372', 'A11.627.482', 'A11.733.397', 'A15.382.670.522', 'A15.382.680.397'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Cervical lymphatic metastases from occult primary tumor. A nation-wide 20-year study from the Danish society of head and neck oncology]. | INTRODUCTION: The management of patients with cervical lymph node metastases from unknown primary tumours is a major challenge in oncology. This study presents data collected from all five oncology centres in Denmark.MATERIALS AND METHODS: Of the 352 consecutive patients with squamous cell or undifferentiated tumours s... | ['Adolescent', 'Adult', 'Aged', 'Carcinoma, Squamous Cell', 'Combined Modality Therapy', 'Denmark', 'Female', 'Head and Neck Neoplasms', 'Humans', 'Lymphatic Metastasis', 'Male', 'Middle Aged', 'Neoplasms, Unknown Primary', 'Prognosis', 'Radiotherapy Dosage'] | 11,257,752 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['E02.186'], ['Z01.542.816.124'], ['C04.588.443'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.697.650.560', 'C23.550.727.650.560'], ['M01.060.116.630'], ['C04.697.650.895', 'C23.550.727.650.895'], ['E01.7... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
Pre-ablative diagnostic whole-body scan following total thyroidectomy for well-differentiated thyroid cancer: is it necessary? | OBJECTIVE: This study reviewed the incidence of positive pre-ablative diagnostic scan after total thyroidectomy and the efficacy of the current ablative dose. The predictive factors for outcome using a standard ablative dose and postoperative complications of total thyroidectomy were also examined.METHODS: This was a r... | ['Adolescent', 'Adult', 'Aged', 'Female', 'Humans', 'Iodine Radioisotopes', 'Malaysia', 'Male', 'Middle Aged', 'Neoplasm, Residual', 'Postoperative Care', 'Postoperative Complications', 'Radionuclide Imaging', 'Radiopharmaceuticals', 'Radiotherapy Dosage', 'Radiotherapy, Adjuvant', 'Retrospective Studies', 'Thyroid Neo... | 15,851,360 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.268.380.400.500.496', 'D01.496.448.496', 'D01.496.749.474'], ['Z01.252.145.487'], ['M01.060.116.630'], ['C04.697.700', 'C23.550.727.700'], ['E02.760.731.700', 'E04.604.500', 'N02.421.585.722.700'], ['C23.550.7... | ['Named Groups [M]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Characterization and cDNA-microarray expression analysis of 12-oxophytodienoate reductases reveals differential roles for octadecanoid biosynthesis in the local versus the systemic wound response. | 12-Oxophytodienoate reductases (OPRs) belong to a family of flavin-dependent oxidoreductases. With two new tomato isoforms reported here, three OPRs have now been characterized in both tomato and Arabidopsis. Only one of these isoforms (OPR3) participates directly in the octadecanoid pathway for jasmonic acid biosynthe... | ['Arabidopsis', 'Cloning, Molecular', 'Cyclopentanes', 'Gene Expression Regulation, Plant', 'Lycopersicon esculentum', 'Molecular Sequence Data', 'Oligonucleotide Array Sequence Analysis', 'Oxidoreductases', 'Oxidoreductases Acting on CH-CH Group Donors', 'Oxylipins', 'Peroxisomes', 'Plant Diseases', 'Plant Leaves', 'S... | 12,445,129 | [['B01.650.940.800.575.912.250.157.100'], ['E05.393.220'], ['D02.455.426.392.368.450'], ['G05.308.375'], ['B01.650.940.800.575.912.250.908.500.322'], ['L01.453.245.667'], ['E05.393.661.640', 'E05.393.760.640', 'E05.588.570.660', 'E05.601.640'], ['D08.811.682'], ['D08.811.682.660'], ['D10.251.355.645'], ['A11.284.430.21... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Wolbachia symbiont infections induce strong cytoplasmic incompatibility in the tsetse fly Glossina morsitans. | Tsetse flies are vectors of the protozoan parasite African trypanosomes, which cause sleeping sickness disease in humans and nagana in livestock. Although there are no effective vaccines and efficacious drugs against this parasite, vector reduction methods have been successful in curbing the disease, especially for nag... | ['Animals', 'Cytoplasm', 'Disease Resistance', 'Female', 'Fertility', 'In Situ Hybridization, Fluorescence', 'Insect Vectors', 'Male', 'Models, Theoretical', 'Pest Control, Biological', 'Phenotype', 'Symbiosis', 'Tsetse Flies', 'Wolbachia'] | 22,174,680 | [['B01.050'], ['A11.284.430.214'], ['C23.550.291.671', 'G12.450.564.250', 'G12.450.800.250', 'G15.630.250'], ['G08.686.210'], ['E01.370.225.500.620.670.325.350', 'E01.370.225.750.600.670.325.350', 'E05.200.500.620.670.325.350', 'E05.200.750.600.670.325.350', 'E05.393.285.350', 'E05.393.661.475.350'], ['N06.850.335.188.... | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Antagonism of cyanide poisoning by dihydroxyacetone. | Dihydroxyacetone (DHA) effectively antagonized the lethal effect of cyanide in mice and rabbits, particularly if administered in combination with thiosulfate. Oral DHA (2 and 4 g/kg) given to mice 10 min before injection (i.p.) of cyanide increased the LD50 values of cyanide from 5.7 mg/kg to 12 and 17.6 mg/kg, respect... | ['Administration, Oral', 'Animals', 'Antidotes', 'Cyanides', 'Dihydroxyacetone', 'Injections, Intravenous', 'Lethal Dose 50', 'Male', 'Mice', 'Rabbits', 'Seizures', 'Thiosulfates'] | 12,044,542 | [['E02.319.267.100'], ['B01.050'], ['D27.505.696.706.037', 'D27.720.799.037'], ['D01.248.497.158.291', 'D01.625.400.100'], ['D09.947.875.465.200', 'D09.947.875.894.200'], ['E02.319.267.082.750', 'E02.319.267.530.540'], ['E05.940.402', 'G07.225.500', 'G07.690.773.875.750', 'G07.690.936.500.750'], ['B01.050.150.900.649.3... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Treatment of a murine model of high-turnover renal osteodystrophy by exogenous BMP-7. | BACKGROUND: The secondary hyperparathyroidism of chronic kidney disease (CKD) produces a high turnover osteodystrophy that is associated with peritrabecular fibrosis. The nature of the cells involved in the development of peritrabecular fibrosis may represent osteoprogenitors expressing a fibroblastic phenotype that ar... | ['Animals', 'Blood Urea Nitrogen', 'Bone Morphogenetic Protein 7', 'Bone Morphogenetic Proteins', 'Bone Remodeling', 'Bone and Bones', 'Chronic Kidney Disease-Mineral and Bone Disorder', 'Fibrosis', 'Hyperparathyroidism, Secondary', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Renal Insufficiency', 'Transforming Growth Facto... | 11,918,739 | [['B01.050'], ['E01.370.225.124.100.115', 'E01.370.390.400.100', 'E05.200.124.100.115'], ['D12.644.276.954.200.700', 'D12.776.467.942.200.700', 'D23.529.942.200.700'], ['D12.644.276.954.200', 'D12.776.467.942.200', 'D23.529.942.200'], ['G11.427.213', 'G16.762.150'], ['A02.835.232', 'A10.165.265'], ['C05.116.198.816.750... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Long-term macrolide treatment for the prevention of acute exacerbations in COPD: a systematic review and meta-analysis. | Background: Acute exacerbation of COPD (AECOPD) is associated with an increased hospitalization and mortality. Azithromycin and erythromycin are the recommended drugs to reduce the risk of exacerbations. However, the most suitable duration of therapy and drug-related adverse events are still a matter of debate. The aim... | ['Aged', 'Anti-Bacterial Agents', 'Azithromycin', 'Disease Progression', 'Drug Administration Schedule', 'Drug Resistance, Bacterial', 'Erythromycin', 'Female', 'Humans', 'Lung', 'Male', 'Pulmonary Disease, Chronic Obstructive', 'Respiratory Tract Infections', 'Risk Factors', 'Time Factors', 'Treatment Outcome'] | 30,538,443 | [['M01.060.116.100'], ['D27.505.954.122.085'], ['D02.540.576.500.992.050'], ['C23.550.291.656'], ['E02.319.283'], ['G06.099.225', 'G06.225.347', 'G07.690.773.984.269.347'], ['D02.540.576.500.992'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A04.411'], ['C08.381.495.389'], ['C01.748', 'C08.730'], ['E05.318.740.6... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Metabolism of the liver tumor promoter ethinyl estradiol by primary cultures of rat hepatocytes. | Previously, we reported that relatively high micromolar concentrations of the liver tumor promoter 17 alpha-ethinyl estradiol (EE2) stimulated DNA synthesis and enhanced the DNA synthetic response to epidermal growth factor (EGF) in primary cultures of female rat hepatocytes [J.D. Yager, B.D Roebuck, T.L. Paluszcyk, an... | ['Animals', 'Carcinogens', 'Cells, Cultured', 'Chromatography, High Pressure Liquid', 'DNA', 'Epidermal Growth Factor', 'Ethinyl Estradiol', 'Female', 'Hydrolysis', 'Liver', 'Rats'] | 2,315,917 | [['B01.050'], ['D27.888.569.100'], ['A11.251'], ['E05.196.181.400.300'], ['D13.444.308'], ['D06.472.317.350', 'D12.644.276.382.500', 'D12.776.467.382.500', 'D23.529.382.500'], ['D04.210.500.668.651.568.291', 'D06.472.334.851.437.968.500'], ['G02.380'], ['A03.620'], ['B01.050.150.900.649.313.992.635.505.700']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Issues on the use of ethnobotanicals]. | AIM: To identify the risk factors for the use of ethnobotanicals and the people at risk to becoming users.MATERIAL AND METHODS: This questionnaire basez objective population study included 89 subjects aged 14 to 42 years.RESULTS: 19.10% of the subjects admitted using ethnobotanicals, most of them being 20-25 years old ... | ['Adolescent', 'Adult', 'Ethnobotany', 'Female', 'Fertilizers', 'Hallucinogens', 'Humans', 'Male', 'Pyrrolidines', 'Risk Factors', 'Romania', 'Substance-Related Disorders', 'Surveys and Questionnaires'] | 22,276,448 | [['M01.060.057'], ['M01.060.116'], ['H01.158.273.118.299'], ['D27.720.031.400'], ['D27.505.696.388', 'D27.505.954.427.700.372'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.383.773'], ['E05.318.740.600.800.725', 'N05.715.350.200.700', 'N05.715.360.750.625.700.700', 'N06.850.490.625.750', 'N06.850.520.830.600... | ['Named Groups [M]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Diseases [C]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
Dietary soy isoflavones reduce pathogen-related mortality in growing pigs under porcine reproductive and respiratory syndrome viral challenge. | Porcine reproductive and respiratory syndrome virus (PRRSV) is an economically important disease, and ingestion of soy isoflavones (ISF) may benefit PRRSV-infected pigs due to demonstrated anti-inflammatory and antiviral properties. The objective of this experiment was to recreate immunological effects previously obser... | ['Animal Feed', 'Animals', 'Antibodies, Viral', 'Diet', 'Dietary Supplements', 'Eating', 'Isoflavones', 'Male', 'Porcine Reproductive and Respiratory Syndrome', 'Porcine respiratory and reproductive syndrome virus', 'Soybeans', 'Swine', 'Weaning'] | 31,960,037 | [['G07.203.300.300.100', 'J02.500.300.100'], ['B01.050'], ['D12.776.124.486.485.114.254', 'D12.776.124.790.651.114.254', 'D12.776.377.715.548.114.254'], ['G07.203.650.240'], ['G07.203.300.456', 'J02.500.456'], ['G07.203.650.283', 'G10.261.330'], ['D03.383.663.283.266.450.400', 'D03.633.100.150.266.450.400'], ['C01.925.... | ['Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
A general framework for statistical linkage analysis in multivalent tetraploids. | In multivalent polyploids, simultaneous pairings among homologous chromosomes at meiosis result in a unique cytological phenomenon-double reduction. Double reduction casts an impact on chromosome evolution in higher plants, but because of its confounded effect on the pattern of gene cosegregation, it complicates linkag... | ['Algorithms', 'Alleles', 'Chromosome Mapping', 'Crosses, Genetic', 'Genes, Plant', 'Genetic Linkage', 'Genetic Markers', 'Genome', 'Genotype', 'Models, Genetic', 'Models, Statistical', 'Monte Carlo Method', 'Ploidies', 'Polymorphism, Genetic', 'Polyploidy', 'Probability', 'Recombination, Genetic', 'Zygote'] | 15,802,525 | [['G17.035', 'L01.224.050'], ['G05.360.340.024.340.030'], ['E05.393.183'], ['E05.393.281'], ['G05.360.340.024.340.393', 'G05.360.340.365.500'], ['G05.348'], ['D23.101.387', 'G05.695.450'], ['G05.360.340'], ['G05.380'], ['E05.599.395.397'], ['E05.318.740.500', 'E05.599.835', 'N05.715.360.750.530', 'N06.850.520.830.500']... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Italian parliamentary debates on energy sustainability: How argumentative 'short-circuits' affect public engagement. | Public engagement is considered a crucial process in the transition towards sustainable energy systems. However, less space has been devoted to understand how policy makers and stakeholders view citizens and their relationship with energy issues. Nonetheless, together with technological advancements, policies and polit... | ['Community Participation', 'Environmental Policy', 'Federal Government', 'Italy', 'Politics', 'Renewable Energy'] | 25,904,600 | [['N02.421.143.212', 'N03.540.245.360'], ['I01.655.500.608.180', 'I01.880.604.825.608.180', 'N03.623.500.608.180', 'N06.230.204'], ['I01.409.137', 'I01.409.418.625', 'N03.540.348.500', 'N03.540.400.750'], ['Z01.542.489'], ['I01.738'], ['N06.230.132.644']] | ['Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.