Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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A longitudinal study of markers of bone turnover in Graves' disease and their value in predicting bone mineral density. | Whether biochemical markers can predict improvement in reduced bone mineral density (BMD) associated with thyrotoxicosis in unclear. We investigated the relationship between serum osteocalcin (OC), bone-specific alkaline phosphatase (b-ALP), serum deoxypyridinoline (Sdpd) and pyridinoline (Spyr), 24-hour urinary deoxyp... | ['Adult', 'Antithyroid Agents', 'Biomarkers', 'Bone Density', 'Bone and Bones', 'Carbimazole', 'Female', 'Forecasting', 'Graves Disease', 'Humans', 'Longitudinal Studies', 'Male', 'Middle Aged', 'Thyrotoxicosis'] | 9,062,477 | [['M01.060.116'], ['D06.347.100', 'D27.505.696.399.450.100'], ['D23.101'], ['G11.427.100'], ['A02.835.232', 'A10.165.265'], ['D03.383.129.308.108'], ['I01.320'], ['C11.675.349.500', 'C19.874.283.605', 'C19.874.397.370', 'C20.111.555'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.500.750.500', 'N05.71... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Hemopneumothorax in a COPD patient treated with noninvasive positive pressure ventilation: the risk of attendant anticoagulation. | Noninvasive positive pressure ventilation (NIPPV) modalities have been proven to be effective in the setting of exacerbations of chronic obstructive pulmonary disease (COPD). Reported complications include pneumothorax, increased work of breathing, gastric distension and air embolism. This case demonstrates that patien... | ['Aged', 'Aged, 80 and over', 'Anticoagulants', 'Hemopneumothorax', 'Hemorrhage', 'Humans', 'Male', 'Pneumothorax', 'Positive-Pressure Respiration', 'Pulmonary Disease, Chronic Obstructive', 'Radiography'] | 15,045,048 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.954.502.119'], ['C08.528.338', 'C23.550.414.904.500'], ['C23.550.414'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C08.528.778'], ['E02.041.625.790', 'E02.880.820.790'], ['C08.381.495.389'], ['E01.370.350.700']] | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Vivian Bullwinkel: A model of resilience and a symbol of strength. | BACKGROUND: The story of one of Australia's most well-known women in history, Vivian Bullwinkel, is a symbol of strength for nursing. She and her companions who were prisoners of war during World War II, refused the position of victim and went on to contribute much to the world after their ordeal.DISCUSSION: These wome... | ['Adaptation, Psychological', 'Australia', 'Female', 'History of Nursing', 'History, 20th Century', 'Humans', 'Military Nursing', 'Prisoners of War', 'Resilience, Psychological', 'Stress, Psychological', 'World War II'] | 26,285,418 | [['F01.058'], ['Z01.639.100', 'Z01.678.100.373'], ['K01.400.608'], ['K01.400.504.968'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H02.478.676.458'], ['M01.729.500'], ['F02.940'], ['F01.145.126.990', 'F02.830.900'], ['I01.880.735.950.250.984', 'K01.400.504.968.901']] | ['Psychiatry and Psychology [F]', 'Geographicals [Z]', 'Humanities [K]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 |
An experimental model of human leukemic meningitis in the nude rat. | An experimental animal model of meningeal leukemia was developed in the nude rat, rnu/rnu, using the human-derived acute lymphoblastic leukemia cell line HPB-ALL. Anesthetized rats were placed in a modified stereotaxic frame and then injected intrathecally, at the level of the cisterna magna, with human leukemic cells.... | ['Animals', 'Disease Models, Animal', 'Humans', 'Leukemia, Experimental', 'Leukemic Infiltration', 'Meninges', 'Precursor Cell Lymphoblastic Leukemia-Lymphoma', 'Rats', 'Rats, Nude'] | 9,207,465 | [['B01.050'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.337.372', 'C04.619.531', 'E05.598.500.496.500'], ['C04.697.645.500', 'C23.550.727.645.500'], ['A08.186.566'], ['C04.557.337.428.600', 'C15.604.515.560.600', 'C20.683.515.528.600'], ['B01.050.150.900.6... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Microscopic spectral imaging using a video camera. | A technique is described which permits the simultaneous acquisition of multiple fluorescent emission and/or absorption spectra from discrete regions of a specimen under microscopic observation. The instrument consists of a modified inverted microscope, an optical diffraction grating, a silicon intensified target (SIT) ... | ['Acridine Orange', 'Animals', 'Blastocyst', 'Cell Nucleus', 'Fluorometry', 'Microscopy', 'Mitosis', 'Rabbits', 'Spectrometry, Fluorescence', 'Spectrophotometry', 'Trophoblasts', 'Video Recording'] | 3,959,067 | [['D03.633.300.046.250.150'], ['B01.050'], ['A16.254.500'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['E05.196.712.516.600'], ['E01.370.350.515', 'E05.595', 'H01.671.617.562'], ['G04.144.220.220.781', 'G05.113.220.781'], ['B01.050.150.900.649.313.968.700'], ['E05.196.712.516.600.676', 'E05.196.867.726'], ['E... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Information Science [L]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Glucoprivic (2DG) eating in rats despite knife cut induced hyperphagia. | Two weeks after parasagittal hypothalamic knife cuts, baseline eating was elevated and 300 mg/kg 2 deoxy-D-glucose (2DG) did not further stimulate food intake. Five weeks postoperatively the food intake baseline had fallen and an eating response to 300 mg/kg 2DG was now seen (p less than 0.005). In this delayed (static... | ['Animals', 'Blood Glucose', 'Deoxy Sugars', 'Deoxyglucose', 'Dose-Response Relationship, Drug', 'Feeding Behavior', 'Female', 'Hypothalamus', 'Rats', 'Sodium Chloride', 'Time Factors'] | 1,187,721 | [['B01.050'], ['D09.947.875.359.448.500'], ['D09.254'], ['D09.254.229'], ['G07.690.773.875', 'G07.690.936.500'], ['F01.145.113.547', 'F01.145.407', 'G07.203.650.353'], ['A08.186.211.180.497', 'A08.186.211.200.317.357'], ['B01.050.150.900.649.313.992.635.505.700'], ['D01.210.450.150.875', 'D01.857.650'], ['G01.910.857']... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Factors affecting glycosaminoglycan concentration in normal human plasma. | Acid Glycosaminoglycans (GAGs) were measured, in terms of hexuronic acid, following alkaline treatment and Ecteola chromatography, in plasma obtained from healthy volunteers, blood-donors, amateur soccer players and university students, and from hospitalized subjects at the end of their convalescence. Diurnal variation... | ['Adolescent', 'Adult', 'Chromatography, Ion Exchange', 'Circadian Rhythm', 'Connective Tissue', 'Exercise', 'Female', 'Glycosaminoglycans', 'Humans', 'Hydrocortisone', 'Male', 'Middle Aged', 'Muscles', 'Reference Values'] | 1,500,281 | [['M01.060.057'], ['M01.060.116'], ['E05.196.181.400.383'], ['G07.180.562.190'], ['A10.165'], ['G11.427.410.698.277', 'I03.350'], ['D09.698.373'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D04.210.500.745.745.654.600', 'D06.472.040.585.353.476', 'D06.472.040.585.478.392'], ['M01.060.116.630'], ['A02.633', 'A10... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Endocytosis of superoxide dismutase by rat liver. | We have investigated the endocytosis by rat liver of superoxide dismutase (SOD) labelled with 125I. (125I) SOD is quickly taken up by the liver where it remains in significant amounts for at least 150 min. Adsorptive endocytosis is probably involved. Distribution of radioactivity was established after differential and ... | ['Animals', 'Cathepsin C', 'Cattle', 'Cell Fractionation', 'Centrifugation, Density Gradient', 'Dipeptidyl-Peptidases and Tripeptidyl-Peptidases', 'Endocytosis', 'Kinetics', 'Liver', 'Lysosomes', 'Male', 'Rats', 'Rats, Inbred Strains', 'Subcellular Fractions', 'Superoxide Dismutase'] | 1,575,746 | [['B01.050'], ['D08.811.277.656.224.130', 'D08.811.277.656.262.186', 'D08.811.277.656.350.350.100'], ['B01.050.150.900.649.313.500.380.271'], ['E05.242.251'], ['E05.181.724.336', 'E05.196.941.336'], ['D08.811.277.656.350.350'], ['G04.417'], ['G01.374.661', 'G02.111.490'], ['A03.620'], ['A11.284.430.214.190.875.190.550'... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Tetra-(p | We have synthesized and structurally characterized three tetra-(p-tolyl)antimony(III)-containing heteropolytungstates, [{(p-tolyl)SbIII}4(A-á-XW9O34)2]n- [X = PV (1-P), AsV (1-As), or GeIV (1-Ge)], in aqueous solution using conventional, one-pot procedures. The polyanions 1-P, 1-As, and 1-Ge were fully characterized in... | ['A549 Cells', 'Anti-Bacterial Agents', 'Antimony', 'Antineoplastic Agents', 'Apoptosis', 'Bacillus subtilis', 'Cell Proliferation', 'Cell Survival', 'Coordination Complexes', 'Drug Screening Assays, Antitumor', 'Escherichia coli', 'Humans', 'Microbial Sensitivity Tests', 'Tumor Cells, Cultured', 'Tungsten', 'Vibrio pa... | 32,037,809 | [['A11.251.210.190.080', 'A11.251.860.180.080', 'A11.436.054'], ['D27.505.954.122.085'], ['D01.268.513.124', 'D01.268.556.050', 'D01.552.544.050'], ['D27.505.954.248'], ['G04.146.954.035'], ['B03.300.390.400.158.218.725', 'B03.353.500.100.218.725', 'B03.510.100.100.218.725', 'B03.510.415.400.158.218.725', 'B03.510.460.... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Population structure of the golden snub-nosed monkey Rhinopithecus roxellana in the Qinling Mountains, central China. | Environmental barriers and habitat fragmentation can restrict gene flow, leading to genetic divergence among animal populations. The golden snub-nosed monkey, Rhinopithecus roxellana, is endemic to China, and ranges across 4 provinces. However, over the past 40 years its populations have become fragmented. We investiga... | ['Animals', 'Bayes Theorem', 'China', 'Colobinae', 'Ecosystem', 'Female', 'Genetic Variation', 'Geography', 'Male', 'Microsatellite Repeats'] | 27,059,276 | [['B01.050'], ['E05.318.740.600.200', 'N05.715.360.750.625.150', 'N06.850.520.830.600.200'], ['Z01.252.474.164'], ['B01.050.150.900.649.313.988.400.112.199.150'], ['G16.500.275.157', 'N06.230.124'], ['G05.365'], ['H01.277.500'], ['G02.111.570.080.708.800.500', 'G05.360.080.708.800.500', 'G05.360.340.024.850.500']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
[Prevention of vaginal prolapse in hysterectomy by suspension of the vaginal stump]. | For prophylaxis of enterocele and of prolapse of the vagina following hysterectomy, the vaginal stump is fixed in at-risk patients to the sacro-uterine ligaments (known as McCall's suture) or to the sacro-spinal ligament (Amreich-Richter method). We report on the indications and results obtained in 101 sacro-spinal fix... | ['Female', 'Humans', 'Hysterectomy', 'Hysterectomy, Vaginal', 'Ligaments', 'Postoperative Complications', 'Risk Factors', 'Sacrococcygeal Region', 'Suture Techniques', 'Urinary Bladder Diseases', 'Uterine Prolapse'] | 2,286,318 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.950.300.399'], ['E04.950.300.399.380'], ['A02.513', 'A10.165.669'], ['C23.550.767'], ['E05.318.740.600.800.725', 'N05.715.350.200.700', 'N05.715.360.750.625.700.700', 'N06.850.490.625.750', 'N06.850.520.830.600.800.725'], ['A01.923.176.780'], ['E04.987.775'], ['C1... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Multivalent Presentation of Cationic Peptides on Supramolecular Nanofibers for Antimicrobial Activity. | Noncovalent and electrostatic interactions facilitate the formation of complex networks through molecular self-assembly in biomolecules such as proteins and glycosaminoglycans. Self-assembling peptide amphiphiles (PA) are a group of molecules that can form nanofibrous structures and may contain bioactive epitopes to in... | ['Anti-Infective Agents', 'Epitopes', 'Nanofibers', 'Peptides'] | 29,020,766 | [['D27.505.954.122'], ['D23.050.550'], ['J01.637.512.300'], ['D12.644']] | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Ophthalmological Evaluation of Integrated Resistance and Aerobic Training During 70-Day Bed Rest. | INTRODUCTION: We evaluated ophthalmic changes in healthy individuals who underwent integrated resistance and aerobic training (iRAT) during 70-d 6° head-down tilt (HDT) bed rest (BR).METHODS: Participants were selected using NASA standard screening procedures. Standardized NASA BR conditions were implemented. Subjects ... | ['Adult', 'Bed Rest', 'Exercise', 'Female', 'Head-Down Tilt', 'Humans', 'Intraocular Pressure', 'Linear Models', 'Male', 'Middle Aged', 'Nerve Fibers', 'Organ Size', 'Resistance Training', 'Retina', 'Tomography, Optical Coherence'] | 28,641,680 | [['M01.060.116'], ['E02.075'], ['G11.427.410.698.277', 'I03.350'], ['G11.427.695.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G14.440'], ['E05.318.740.500.500', 'E05.318.740.750.425', 'E05.599.835.750', 'N05.715.360.750.530.460', 'N05.715.360.750.695.460', 'N06.850.520.830.500.500', 'N06.850.520.830.750.42... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Utilization and outcomes of inpatient surgical care at critical access hospitals in the United States. | IMPORTANCE: There is a growing interest in the quality and cost of care provided at Critical Access Hospitals (CAHs), a predominant source of care for many rural populations in the United States.OBJECTIVE: To evaluate utilization, outcomes, and costs of inpatient surgery performed at CAHs.DESIGN, SETTING, AND PATIENTS:... | ['Adult', 'Aged', 'Aged, 80 and over', 'Cost Savings', 'Female', 'Health Services Accessibility', 'Hospital Costs', 'Hospital Mortality', 'Hospitals, Rural', 'Humans', 'Length of Stay', 'Male', 'Middle Aged', 'Outcome Assessment, Health Care', 'Retrospective Studies', 'Surgical Procedures, Operative', 'United States'] | 23,636,896 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['N03.219.151.160.200'], ['N04.590.374.350', 'N05.300.430'], ['N03.219.151.400.687', 'N03.219.262.500', 'N05.300.375.500'], ['E05.318.308.985.550.400', 'N01.224.935.698.400', 'N06.850.505.400.975.550.400', 'N06.850.520.308.985.550.400'], ['N02.278.421.518'... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
Overall indices for assessing agreement among multiple raters. | The need to assess agreement exists in various clinical studies where quantifying inter-rater reliability is of great importance. Use of unscaled agreement indices, such as total deviation index and coverage probability (CP), is recommended for two main reasons: (i) they are intuitive in a sense that interpretations ar... | ['Bias', 'Chi-Square Distribution', 'Data Interpretation, Statistical', 'Humans', 'Models, Statistical', 'Observer Variation'] | 30,062,738 | [['N05.715.350.150', 'N06.850.490.500'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['E05.245.380', 'E05.318.740.300', 'L01.313.500.750.190.380', 'N05.715.360.750.300', 'N06.850.520.830.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500', 'E05.59... | ['Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Cloning and characterization of motY, a gene coding for a component of the sodium-driven flagellar motor in Vibrio alginolyticus. | The bacterial flagellar motor is a molecular machine that couples proton or sodium influx to force generation for driving rotation of the helical flagellar filament. In this study, we cloned a gene (motY) encoding a component of the sodium-driven polar flagellar motor in Vibrio alginolyticus. Nucleotide sequence analys... | ['Amiloride', 'Amino Acid Sequence', 'Bacterial Outer Membrane Proteins', 'Base Sequence', 'Cloning, Molecular', 'Flagella', 'Gene Expression Regulation, Bacterial', 'Genes, Bacterial', 'Molecular Sequence Data', 'Movement', 'Regulatory Sequences, Nucleic Acid', 'Sequence Analysis, DNA', 'Sequence Homology, Amino Acid'... | 8,636,046 | [['D03.383.679.149'], ['G02.111.570.060', 'L01.453.245.667.060'], ['D12.776.097.120', 'D12.776.543.100'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.393.220'], ['A11.284.180.290'], ['G05.308.300'], ['G05.360.340.024.340.364.249', 'G05.360.340.358.024.249', 'G05.360.340.358.207.249'], ['L01.453.245... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Reduced natural killer T-cells in B-cell chronic lymphocytic leukaemia identified by three monoclonal antibodies: Leu-11, A10, AB8.28. | The proportion of E-rosette positive T-lymphocytes capable of reacting with three monoclonal antibodies (MoAbs)--Leu-11, A10, AB8.28--which appear to recognize specifically natural killer (NK) cells, was assessed in a series of untreated patients with B-cell chronic lymphocytic leukaemia (B-CLL). Irrespective of the cl... | ['Antibodies, Monoclonal', 'B-Lymphocytes', 'Humans', 'Killer Cells, Natural', 'Leukemia, Lymphoid', 'Phenotype', 'T-Lymphocytes'] | 3,484,634 | [['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.118.637.555.567.537', 'A15.145.229.637.555.567.5... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Role of c-MYC in alternative activation of human macrophages and tumor-associated macrophage biology. | In response to microenvironmental signals, macrophages undergo different activation, including the "classic" proinflammatory phenotype (also called M1), the "alternative" activation induced by the IL-4/IL-13 trigger, and the related but distinct heterogeneous M2 polarization associated with the anti-inflammatory profil... | ['Biomarkers, Tumor', 'Blotting, Western', 'Breast Neoplasms', 'Cell Differentiation', 'Cells, Cultured', 'Chromatin Immunoprecipitation', 'Colon', 'Colonic Neoplasms', 'Female', 'Gene Expression Profiling', 'Gene Expression Regulation, Neoplastic', 'Humans', 'Interleukin-4', 'Macrophage Activation', 'Macrophages', 'Ol... | 22,067,385 | [['D23.101.140'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['C04.588.180', 'C17.800.090.500'], ['G04.152'], ['A11.251'], ['E05.393.170', 'E05.478.605.160'], ['A03.556.124.526.356', 'A03.556.249.249.356'], ['C04.588.274.476.411.307.180', 'C06.301.371.411.307.18... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Development of DexAide right ventricular assist device: update II. | The DexAide right ventricular assist device (RVAD) is a magnetically and hydrodynamically levitated implantable centrifugal pump. Recent progress includes 1) redesign of the inflow/outflow conduits, which yielded two successful 3-month experiments, 2) development of alternative journal bearing materials, and 3) complet... | ['Algorithms', 'Animals', 'Cattle', 'Disease Models, Animal', 'Equipment Design', 'Heart Failure', 'Heart-Assist Devices', 'Hemodynamics'] | 19,033,771 | [['G17.035', 'L01.224.050'], ['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['E05.320'], ['C14.280.434'], ['E04.050.430', 'E07.695.300.300', 'E07.858.082.374.300'], ['G09.330.380']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Pharmacological characterization of the adenylate cyclase-coupled adenosine receptor in isolated guinea pig atrial myocytes. | Although adenosine is known to activate K+ conduction in atrial tissue, there is still debate as to the involvement of cAMP-dependent mechanisms. In isolated adult guinea pig atrial myocytes, we demonstrate that the highly A1-selective adenosine receptor agonist 2-chloro-N6-cyclopentyladenosine reduced basal cAMP level... | ['4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone', 'Adenosine', 'Adenylate Cyclase Toxin', 'Adenylyl Cyclases', 'Animals', 'Carrier Proteins', 'Cyclic AMP', 'Cyclic AMP Receptor Protein', 'Female', 'Guinea Pigs', 'Heart Atria', 'Isoproterenol', 'Male', 'Myocardium', 'Pertussis Toxin', 'Virulence Factors, Bordetella'] | 2,163,017 | [['D03.383.129.308.100'], ['D03.633.100.759.590.138', 'D13.570.583.138', 'D13.570.800.096'], ['D08.811.520.650.200.040', 'D23.946.123.946.040', 'D23.946.896.980.040'], ['D08.811.520.650.200', 'D12.644.360.050', 'D12.776.476.050'], ['B01.050'], ['D12.776.157'], ['D03.633.100.759.646.138.395', 'D13.695.462.200', 'D13.695... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
"I spy with my little eye!": breadth of attention, inattentional blindness, and tactical decision making in team sports. | Failures of awareness are common when attention is otherwise engaged. Such failures are prevalent in attention-demanding team sports, but surprisingly no studies have explored the inattentional blindness paradigm in complex sport game-related situations. The purpose of this paper is to explore the link between breadth ... | ['Adolescent', 'Attention', 'Awareness', 'Computer Simulation', 'Creativity', 'Decision Making', 'Group Processes', 'Humans', 'Male', 'Motion Perception', 'Orientation', 'Sports', 'Video Recording', 'Visual Perception'] | 17,876,972 | [['M01.060.057'], ['F02.830.104.214'], ['F02.463.188.150'], ['L01.224.160'], ['F01.752.264', 'F02.463.785.302'], ['F02.463.785.373'], ['F01.829.316'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.593.932.567'], ['F01.058.577', 'F02.830.606'], ['I03.450.642.845'], ['L01.280.960'], ['F02.463.593.932']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Information Science [L]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 |
Animation of natural scene by virtual eye-movements evokes high precision and low noise in V1 neurons. | Synaptic noise is thought to be a limiting factor for computational efficiency in the brain. In visual cortex (V1), ongoing activity is present in vivo, and spiking responses to simple stimuli are highly unreliable across trials. Stimulus statistics used to plot receptive fields, however, are quite different from those... | ['Action Potentials', 'Animals', 'Cats', 'Eye Movements', 'Neurons', 'Photic Stimulation', 'Signal-To-Noise Ratio', 'Visual Cortex', 'Visual Fields', 'Visual Perception'] | 24,409,121 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['B01.050'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['G11.427.410.140', 'G14.350'], ['A08.675', 'A11.671'], ['E05.723.729'], ['E05.318.370.800.875', 'E05.318.740.872.875', 'G17.800.500', 'N05.715.360.325.700.840', 'N05.715.360.750.725.750', 'N06.850.520.... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
The ciliogenic protein Oral-Facial-Digital 1 regulates the neuronal differentiation of embryonic stem cells. | Oral-Facial-Digital 1 (OFD1) Syndrome is an X-linked developmental disorder caused by mutations in the gene Ofd1. OFD1 syndrome involves malformation of the face, oral cavity, and digits and may be characterized by cystic kidneys and mental retardation. Deletion or missense mutations in Ofd1 also result in loss of prim... | ['Animals', 'Cell Differentiation', 'Cilia', 'Disease Models, Animal', 'Embryoid Bodies', 'Female', 'Gene Expression Regulation, Developmental', 'Genetic Diseases, X-Linked', 'Hedgehog Proteins', 'Mice', 'Mice, Transgenic', 'Mutation', 'Neurons', 'Orofaciodigital Syndromes', 'Proteins', 'Signal Transduction', 'Wnt Prot... | 20,873,986 | [['B01.050'], ['G04.152'], ['A11.284.180.165'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['A11.872.700.250.260'], ['G05.308.310'], ['C16.320.322'], ['D12.644.276.671', 'D12.776.467.671', 'D23.529.671'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.136.500', 'B01.050.150.900.649.313.992.635.505.500.8... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Autoimmunity to tropomyosin isoforms in ulcerative colitis (UC) patients and unaffected relatives. | Autoimmunity to cytoskeletal protein tropomyosin (TM) has been demonstrated in UC. However, the TM isoforms involved in this IgG-mediated autoimmune response in UC and the possible presence of serum IgG antibodies against TM (hTMs IgG) in unaffected UC relatives are unknown. The aim of this study was to investigate the... | ['Adolescent', 'Adult', 'Aged', 'Antibodies, Antineutrophil Cytoplasmic', 'Autoantibodies', 'Autoimmunity', 'Chronic Disease', 'Colitis, Ulcerative', 'Crohn Disease', 'Family', 'Female', 'Humans', 'Ileitis', 'Immunoglobulin G', 'Male', 'Middle Aged', 'Pedigree', 'Tropomyosin'] | 9,717,968 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['D12.776.124.486.485.114.323.190', 'D12.776.124.790.651.114.323.190', 'D12.776.377.715.548.114.323.190', 'D23.101.050'], ['D12.776.124.486.485.114.323', 'D12.776.124.790.651.114.323', 'D12.776.377.715.548.114.323'], ['G12.450.192'], ['C23.550.291.500'], ['C06.405... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Primary malignant melanoma of the vagina. | BACKGROUND: Primary vaginal melanoma is a rare, highly malignant, and poor prognostic disease.CASE: The 51-year-old patient with diagnosis of vaginal malignant melanoma was referred to our clinic. Since detection of pervasive brown lesions in the vagina total vaginectomy was performed. At pathological investigation mel... | ['Antineoplastic Combined Chemotherapy Protocols', 'Cisplatin', 'Dacarbazine', 'Female', 'Humans', 'Interferon-alpha', 'Lymphatic Metastasis', 'Melanoma', 'Middle Aged', 'Temozolomide', 'Vaginal Neoplasms'] | 19,242,707 | [['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['D01.210.375', 'D01.625.125', 'D01.710.100'], ['D02.925.200', 'D03.383.129.308.240'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.440.890.250', 'D12.776.467.374.440.890.250', 'D23.529.374.440.890.250'], ['C04.697.650.560', 'C23.550.727.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Mid-upper arm circumference and weight-for-height to identify high-risk malnourished under-five children. | The World Health Organization and UNICEF define non-oedematous severe acute malnutrition (SAM) either by a mid-upper arm circumference (MUAC) less than 115 mm or by a weight-for-height z-score (WHZ) less than -3. The objective of this study was to assess whether there was any benefit to identify malnourished children w... | ['Anthropometry', 'Arm', 'Body Height', 'Body Mass Index', 'Body Weight', 'Child Nutrition Disorders', 'Child, Preschool', 'Female', 'Humans', 'Infant', 'Infant Nutrition Disorders', 'Infant, Newborn', 'Male', 'ROC Curve'] | 21,951,349 | [['E01.370.600.024', 'E05.041', 'N06.850.505.200.100'], ['A01.378.800.075'], ['E01.370.600.115.100.160.100', 'E05.041.124.160.500', 'G07.100.100.160.100', 'G07.345.249.314.100'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['C23.888.144', 'E01.370.600.115.100.160.120', ... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Named Groups [M]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Risk factors for developing liver cancer in people with and without liver disease. | BACKGROUND: The National Liver Cancer Surveillance Program (NLCSP) targets patients with liver diseases that lead to liver cancer in South Korea. This study aimed to investigate the risk of liver disease leading to liver cancer using nationally representative data to establish an efficient NLCSP.METHODS: This study use... | ['Adult', 'Aged', 'Child, Preschool', 'Cohort Studies', 'Female', 'Humans', 'Infant', 'Infant, Newborn', 'Liver Neoplasms', 'Male', 'Middle Aged', 'Risk Factors', 'Young Adult'] | 30,372,481 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.406.448'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['C04.588.274.623', 'C06.301.623', 'C06.552.697'], ['M01.060.116.630'], ['E05.318.740.600.800.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Central nervous system involvement at presentation in the chronic phase of chronic myelogenous leukemia in childhood. | With the advent of more effective chemotherapy an increasing incidence of central nervous system involvement in acute lymphocyte (ALL) and myelocytic leukemias (AML) and chronic myelocytic leukemia (CML) in blast crisis has become evident. Meningeal involvement in the chronic phase of CML is rare. We report two childre... | ['Adolescent', 'Antineoplastic Agents', 'Centrifugation', 'Child', 'Drug Therapy, Combination', 'Humans', 'Leukemia, Myeloid', 'Leukocyte Count', 'Male', 'Meningeal Neoplasms', 'Retinal Diseases', 'Time Factors'] | 276,416 | [['M01.060.057'], ['D27.505.954.248'], ['E05.181'], ['M01.060.406'], ['E02.319.310'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.337.539'], ['E01.370.225.500.195.107.595', 'E01.370.225.625.107.595', 'E05.200.500.195.107.595', 'E05.200.625.107.595', 'E05.242.195.107.595', 'G04.140.107.595', 'G09.188.105.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Early predictors for the diagnosis of liver abscess in the emergency department. | Diagnosing pyogenic liver abscess (PLA) in the emergency department (ED) is challenging due to its non-specific clinical presentation. We aim to identify predictors that aid in diagnosis of PLA in ED patients. This retrospective chart review included patients diagnosed with PLA in a tertiary hospital between January 20... | ['Adult', 'Aged', 'Comorbidity', 'Emergency Service, Hospital', 'Female', 'Humans', 'Liver Abscess, Pyogenic', 'Male', 'Mass Screening', 'Middle Aged', 'Prospective Studies', 'Retrospective Studies', 'Singapore'] | 30,847,718 | [['M01.060.116'], ['M01.060.116.100'], ['N05.715.350.225', 'N06.850.490.687'], ['N02.278.216.500.968.336', 'N02.421.297.195', 'N04.452.442.452.422.336'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C01.830.025.020.455.730', 'C06.552.597.758'], ['E01.370.500', 'E05.318.308.980.438.580', 'N02.421.726.233.443', 'N0... | ['Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
A polymorphism in the agouti signaling protein gene is associated with human pigmentation. | In mice and humans, binding of alpha-melanocyte--stimulating hormone to the melanocyte-stimulating--hormone receptor (MSHR), the protein product of melanocortin-1 receptor (MC1R) gene, leads to the synthesis of eumelanin. In the mouse, ligation of MSHR by agouti signaling protein (ASP) results in the production of pheo... | ['Aging', 'Agouti Signaling Protein', 'European Continental Ancestry Group', 'Eye Color', 'Female', 'Gene Frequency', 'Genetic Predisposition to Disease', 'Genotype', 'Hair Color', 'Humans', 'Intercellular Signaling Peptides and Proteins', 'Male', 'Melanoma', 'Odds Ratio', 'Phenotype', 'Pigmentation', 'Polymorphism, Ge... | 11,833,005 | [['G07.345.124'], ['D12.644.276.049', 'D12.776.467.049', 'D23.529.049'], ['M01.686.508.400'], ['G14.340', 'G16.690.360'], ['G05.330'], ['C23.550.291.687.500', 'G05.380.355'], ['G05.380'], ['G13.500', 'G16.690.490'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276', 'D12.776.467', 'D23.529'], ['C04.557.46... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Trimeric and Tetrameric A-Type Procyanidins from Peanut Skins. | Peanut skins are a rich source of oligomeric and polymeric procyanidins. The oligomeric fractions are dominated by dimers, trimers, and tetramers. A multistep chromatographic fractionation led to the isolation of four new A-type procyanidins of tri- and tetrameric structures. The structures of the new trimers were defi... | ['Arachis', 'Biflavonoids', 'Catechin', 'Dose-Response Relationship, Drug', 'Molecular Structure', 'Nuclear Magnetic Resonance, Biomolecular', 'Proanthocyanidins', 'Tumor Necrosis Factor-alpha'] | 28,231,711 | [['B01.650.940.800.575.912.250.401.077'], ['D03.383.663.283.266.450.190', 'D03.633.100.150.266.450.190'], ['D03.383.663.283.240.190', 'D03.383.663.283.266.450.206', 'D03.633.100.150.240.190', 'D03.633.100.150.266.450.206'], ['G07.690.773.875', 'G07.690.936.500'], ['G02.111.570', 'G02.466'], ['E05.196.867.519.550'], ['D... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Entamoeba invadens: identification of ADF/cofilin and their expression analysis in relation to encystation and excystation. | The differentiation processes of excystation and encystation of Entamoeba are essential for infection and completion of their life-cycle, and the processes need cell motility and its control by actin cytoskeletal reorganization. This study investigated actin depolymerizing factor (ADF)/cofilin (Cfl) family proteins, wh... | ['Actin Depolymerizing Factors', 'Amino Acid Sequence', 'Animals', 'Cloning, Molecular', 'Cytochalasin D', 'DNA, Protozoan', 'Entamoeba', 'Gene Expression', 'Immune Sera', 'Nucleic Acid Synthesis Inhibitors', 'Phylogeny', 'Polymerase Chain Reaction', 'RNA, Messenger', 'RNA, Protozoan', 'Rabbits', 'Sequence Alignment'] | 20,691,182 | [['D05.750.078.730.212', 'D12.776.220.525.212'], ['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['E05.393.220'], ['D03.633.100.473.231.450', 'D23.946.587.370.450'], ['D13.444.308.442'], ['B01.046.500.100.700.335'], ['G05.297'], ['A12.207.152.846.500', 'D12.776.124.486.485.114.573', 'D12.776.124.790.651.114.57... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Purification and mechanism of activation of a nerve growth factor-sensitive S6 kinase from PC12 cells. | A nerve growth factor (NGF)-sensitive S6 kinase was purified by alkaline lysis of PC12 cells. The activity in lysates from NGF-treated cells was 10-20-fold higher than that from controls. Half-maximal stimulation of the S6 kinase by NGF treatment occurred in approximately 5 min, and the activity returned almost to basa... | ['Adrenal Gland Neoplasms', 'Animals', 'Calcium', 'Calmodulin', 'Cell Line', 'Chlorpromazine', 'Egtazic Acid', 'Kinetics', 'Molecular Weight', 'Nerve Growth Factors', 'Pheochromocytoma', 'Protein Kinases', 'Ribosomal Protein S6 Kinases', 'Sodium Fluoride', 'Vanadates', 'Vanadium'] | 3,102,477 | [['C04.588.322.078', 'C19.053.347', 'C19.344.078'], ['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D12.644.360.372.249', 'D12.776.157.125.412.249', 'D12.776.476.387.249'], ['A11.251.210'], ['D02.886.369.198', 'D03.633.300.783.198'], ['D02.092.782.258.368.257', 'D02.241.081.018.269'], ['G01.374.66... | ['Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Current status of modern fully porous coated metal-on-metal hip resurfacing arthroplasty. | Between March 2007 and July 2010, 1000 consecutive fully porous coated hip resurfacing arthroplasties (HRA) were performed by a single surgeon in 871 patients. The average length of follow-up was 3 ± 1 years. Three cases (0.3%) in three patients showed adverse wear related failures. Another 17 (1.7%) failures were iden... | ['Adolescent', 'Adult', 'Aged', 'Arthroplasty, Replacement, Hip', 'Biocompatible Materials', 'Child', 'Female', 'Hip Joint', 'Hip Prosthesis', 'Humans', 'Joint Diseases', 'Male', 'Metals', 'Middle Aged', 'Treatment Outcome', 'Young Adult'] | 23,680,504 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['E04.555.110.110.110', 'E04.650.110.110', 'E04.680.101.110.110'], ['D25.130', 'D27.720.102.130', 'J01.637.051.130'], ['M01.060.406'], ['A02.835.583.411'], ['E07.695.400.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C05.550'], ['D01.552'], ['M01.060.11... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
[Effects of low-dose pergolide therapy on cardiac valves in patients with Parkinson's disease]. | BACKGROUND: Pergolide mesilate is widely used to treat Parkinson's disease in both the USA and Japan, but the maintenance dose is distinctly different between the USA (usually more than 1.5 mg/day) and Japan (usually less than 1.5 mg/day). Although several reports from the USA have suggested that mitral, aortic, and tr... | ['Aged', 'Aged, 80 and over', 'Antiparkinson Agents', 'Dose-Response Relationship, Drug', 'Echocardiography, Doppler', 'Female', 'Heart Valves', 'Humans', 'Male', 'Middle Aged', 'Parkinson Disease', 'Pergolide'] | 16,389,741 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.954.427.090.050'], ['G07.690.773.875', 'G07.690.936.500'], ['E01.370.350.130.750.220', 'E01.370.350.850.220.220', 'E01.370.350.850.850.220', 'E01.370.370.380.220.220'], ['A07.541.510'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C10.2... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A new device to measure the three dimensional forces and torques in precision grip. | Fine prehension is ubiquitous in everyday skilled hand manipulations. The anticipatory nature of the control of normal grip forces exerted against tangential loads has been extensively used to provide insights into the working of neural control of movements. We designed a new versatile device to measure the three dimen... | ['Adult', 'Biomechanical Phenomena', 'Equipment Design', 'Hand Strength', 'Humans', 'Male', 'Pressure', 'Signal Processing, Computer-Assisted', 'Torque'] | 19,085,185 | [['M01.060.116'], ['G01.154.090', 'G01.374.089'], ['E05.320'], ['E01.370.600.425.500', 'G11.427.560.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.374.715'], ['L01.224.800'], ['G01.374.860.500']] | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Optimization of alpha-amylase immobilization in calcium alginate beads. | alpha-Amylase enzyme was produced by Aspergillus sclerotiorum under SSF conditions, and immobilized in calcium alginate beads. Effects of immobilization conditions, such as alginate concentration, CaCl(2) concentration, amount of loading enzyme, bead size, and amount of beads, on enzymatic activity were investigated. O... | ['Adsorption', 'Alginates', 'Aspergillus', 'Culture Media', 'Enzyme Activation', 'Enzyme Stability', 'Enzymes, Immobilized', 'Glucuronic Acid', 'Hexuronic Acids', 'Hydrogen-Ion Concentration', 'Microspheres', 'Starch', 'Temperature', 'alpha-Amylases'] | 17,516,249 | [['G01.030', 'G02.020'], ['D09.698.068'], ['B01.300.381.081'], ['D27.720.470.305', 'E07.206'], ['G02.111.263', 'G03.328'], ['E05.916.360', 'G02.111.700.500'], ['D08.811.180', 'D12.776.463.500'], ['D02.241.081.844.915.162.249', 'D02.241.152.811.162.500', 'D02.241.511.902.915.162.500', 'D09.811.922.162.500'], ['D02.241.0... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[Routine preoperative testing: Impact of implementation of local recommendations in a teaching hospital]. | OBJECTIVE: to compare the number and the cost of preoperative tests ordered before scheduled surgery before and after implementation of local guidelines.STUDY DESIGN: observational retrospective survey.PATIENTS: All patients scheduled in seven surgical specialties.METHODS: all preoperative tests ordered during a 1-week... | ['Diagnostic Tests, Routine', 'Guideline Adherence', 'Hospitals, Teaching', 'Humans', 'Preoperative Care', 'Retrospective Studies'] | 21,112,727 | [['E01.370.395'], ['N04.761.337', 'N05.715.360.395'], ['N02.278.020.300', 'N02.278.421.639'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.760.795', 'E04.604.750', 'N02.421.585.795'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Counseling by epileptologists affects contraceptive choices of women with epilepsy. | INTRODUCTION: There are several important interactions between antiepileptic drugs (AEDs) and hormonal contraception that need to be carefully considered by women with epilepsy (WWE) and their practitioners. Many AEDs induce hepatic enzymes and decrease the efficacy of hormonal contraception. In addition, estrogen-cont... | ['Adolescent', 'Adult', 'Anticonvulsants', 'Choice Behavior', 'Cohort Studies', 'Contraception', 'Contraceptive Agents', 'Counseling', 'Drug Interactions', 'Epilepsy', 'Female', 'Follow-Up Studies', 'Humans', 'Intrauterine Devices', 'Lamotrigine', "Physician's Role", 'Pregnancy', 'Retrospective Studies', 'Triazines', '... | 27,829,186 | [['M01.060.057'], ['M01.060.116'], ['D27.505.954.427.080'], ['F02.463.785.373.346'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E02.875.194'], ['D27.505.696.875.360', 'D27.505.954.705.360'], ['F02.784.176', 'F04.408.413', 'N02.421.143.303', 'N02.421.461.363'], ['G07.690.773.968'], ... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Physicians' accuracy in manual computation. | Parenteral alimentation fluids are now part of routine nutritional support in the neonatal intensive care unit, and a number of software products are available to help physicians with the formulations. Use of these products is based on the assumption that an appreciable amount of error occurs during manual computation,... | ['Data Interpretation, Statistical', 'Mathematical Computing', 'Mathematics', 'Parenteral Nutrition'] | 2,112,219 | [['E05.245.380', 'E05.318.740.300', 'L01.313.500.750.190.380', 'N05.715.360.750.300', 'N06.850.520.830.300'], ['L01.224.680'], ['H01.548'], ['E02.421.505', 'E02.642.500.505']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Effectiveness of endothelial cell seeding on patency of damaged vascular surfaces in a canine model. | The effects of endothelial cell seeding, which is assumed to be an effective technique to improve patency rates of denuded vascular surfaces, were investigated in an experimental model. In this study, after anesthetic induction, jugular veins of 16 dogs were harvested bilaterally. Endothelial cells were extracted enzym... | ['Animals', 'Arteries', 'Cells, Cultured', 'Dogs', 'Endothelium, Vascular', 'Female', 'Male', 'Vascular Patency'] | 11,414,087 | [['B01.050'], ['A07.015.114'], ['A11.251'], ['B01.050.150.900.649.313.750.250.216.200'], ['A07.015.700.500', 'A10.272.491.355'], ['G09.330.920']] | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Selective matrix metalloproteinase inhibition with developing heart failure: effects on left ventricular function and structure. | The matrix metalloproteinases (MMPs) are an endogenous family of proteolytic enzymes implicated to contribute to LV remodeling. However, broad-spectrum MMP inhibition (MMPi), particularly inhibition of interstitial collagenase (MMP-1), may not be clinically applicable. This study examined the effects of selective MMPi ... | ['Animals', 'Cardiac Pacing, Artificial', 'Diastole', 'Disease Models, Animal', 'Disease Progression', 'Enzyme Inhibitors', 'Heart Failure', 'Hemodynamics', 'Matrix Metalloproteinase 2', 'Matrix Metalloproteinase Inhibitors', 'Matrix Metalloproteinases', 'Myocardium', 'Neurotransmitter Agents', 'Swine', 'Systole', 'Ven... | 12,574,145 | [['B01.050'], ['E02.331.200'], ['G09.330.580.295', 'G11.427.494.554.250', 'G11.427.494.570.295'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['C23.550.291.656'], ['D27.505.519.389'], ['C14.280.434'], ['G09.330.380'], ['D08.811.277.656.300.480.205.352', 'D08.811.277.656.300.480.252.420', 'D08.811.277.656.300.480.525... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Photochemically induced, graded cerebral infarction in the mouse by laser irradiation evolution of brain edema. | Cerebral infarction was produced in mice by intravenous injection of a photosensitive dye, rose bengal (10 mg/kg), and by focal illumination of the intact skull surface for 3 min with a laser source, operating at 570 nm with power levels of 2, 5, 10, and 20 mW. Location of infarction was made using 2,3,5-triphenyltetra... | ['Animals', 'Brain Chemistry', 'Brain Edema', 'Cerebral Cortex', 'Cerebral Infarction', 'Disease Models, Animal', 'Injections, Intravenous', 'Lasers', 'Male', 'Mice', 'Photochemistry', 'Rose Bengal', 'Spectrophotometry', 'Time Factors', 'Water-Electrolyte Balance'] | 1,581,608 | [['B01.050'], ['G02.111.150', 'G03.185'], ['C10.228.140.187'], ['A08.186.211.200.885.287.500'], ['C10.228.140.300.150.477.200', 'C10.228.140.300.775.200.200', 'C14.907.253.092.477.200', 'C14.907.253.855.200.200', 'C23.550.513.355.250.200', 'C23.550.717.489.250.200'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['E02... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Anterior internal capsule volumes increase in patients with schizophrenia switched from typical antipsychotics to olanzapine. | Abnormalities in connectivity are thought to contribute to the symptoms of schizophrenia. Accumulating evidence suggests that antipsychotic medication affects both subcortical and cortical grey and white matter volumes. The goal of this study was to investigate the effects of antipsychotic medication on two white matte... | ['Adult', 'Antipsychotic Agents', 'Benzodiazepines', 'Case-Control Studies', 'Corpus Callosum', 'Dose-Response Relationship, Drug', 'Female', 'Follow-Up Studies', 'Humans', 'Internal Capsule', 'Magnetic Resonance Imaging', 'Male', 'Olanzapine', 'Schizophrenia', 'Young Adult'] | 20,360,156 | [['M01.060.116'], ['D27.505.696.277.950.040', 'D27.505.954.427.210.950.040', 'D27.505.954.427.700.872.331'], ['D03.633.100.079.080'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['A08.186.211.200.885.800.750'], ['G07.690.773.875', 'G07.690.936.500'], ['E05.318.372.500.750.249', 'N05.7... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Cyclic RGD functionalized liposomes encapsulating urokinase for thrombolysis. | Thrombosis, a critical event in blood vessels, not only is associated with myocardial infarction and stroke, but also accounts for considerable morbidity and mortality. Thrombolytic drugs are usually applied to the treatment of acute myocardial infarction, acute cerebral infarction and pulmonary embolism. However, thro... | ['Animals', 'Disease Models, Animal', 'Enzymes, Immobilized', 'Humans', 'Liposomes', 'MCF-7 Cells', 'Male', 'Mice', 'Mice, Inbred BALB C', 'Peptides, Cyclic', 'Thrombolytic Therapy', 'Thrombosis', 'Urokinase-Type Plasminogen Activator'] | 29,412,186 | [['B01.050'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['D08.811.180', 'D12.776.463.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D25.479.517', 'D26.255.260.517', 'J01.637.051.479.517', 'J01.637.087.500.517'], ['A11.251.210.190.630'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
WSAVA nutritional assessment guidelines. | OBJECTIVES: Careful assessment of the nutritional needs of cats and dogs must be taken into consideration in order to maintain optimum health, be part of a treatment regimen for a diseased state, or to maximize the quality of life in all animals. The goal of these World Small Animal Veterinary Association (WSAVA) Guide... | ['Animal Nutritional Physiological Phenomena', 'Animals', 'Cats', 'Dogs', 'Nutrition Assessment', 'Physical Examination', 'Societies', 'Veterinary Medicine'] | 21,704,901 | [['G07.203.650.161'], ['B01.050'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['B01.050.150.900.649.313.750.250.216.200'], ['E05.318.308.585', 'N05.715.360.300.560', 'N06.850.505.557', 'N06.850.520.308.585'], ['E01.370.600'], ['N03.540.828'], ['H02.956']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
The air-fluid level in cavitary pulmonary tuberculosis. | Pulmonary tuberculosis has long been associated with the formation of cavities in the lung. Many reports in the literature indicate that the occurrence of air-fluid levels in tuberculosis is unusual. The authors present 18 cases of proved active cavitary tuberculosis where air-fluid levels occurred during the active ph... | ['Adult', 'Diagnosis, Differential', 'Female', 'Humans', 'Lung Abscess', 'Male', 'Radiography', 'Tuberculosis, Pulmonary'] | 644,050 | [['M01.060.116'], ['E01.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C01.748.407', 'C01.830.025.490', 'C08.381.450', 'C08.730.407'], ['E01.370.350.700'], ['C01.150.252.410.040.552.846.899', 'C01.748.939', 'C08.381.922', 'C08.730.939']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Subdural hygroma versus atrophy on MR brain scans: "the cortical vein sign". | PURPOSE: To determine if the position of the superficial cerebral cortical veins can be used to distinguish subdural hygroma from atrophy on MR brain scans.METHODS: Retrospective review of MR scans obtained in cases of extracerebral fluid collections, separating these into two groups, ie, subdural hygroma or atrophy.FI... | ['Atrophy', 'Brain', 'Brain Neoplasms', 'Cerebral Cortex', 'Cerebral Veins', 'Diagnosis, Differential', 'Humans', 'Lymphangioma', 'Magnetic Resonance Imaging', 'Subdural Space'] | 1,414,825 | [['C23.300.070'], ['A08.186.211'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['A08.186.211.200.885.287.500'], ['A07.015.908.155'], ['E01.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.375.450'], ['E01.370.350.825.500'], ['A08.186.566.395.687']] | ['Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Reye's syndrome: incidence and time trends in Olmsted County, MN, 1950-1981. | Incidence and time trends of Reye's syndrome have been determined in Olmsted County, MN, using the facilities of the Rochester Epidemiology Program Project at Mayo Clinic. Incidence rates in individuals under 18 years of age were 1.1 per 100,000 person-years in the 1970-75 time interval and 1.7 in the 1976-81 interval.... | ['Adolescent', 'Child', 'Child, Preschool', 'Female', 'Humans', 'Male', 'Minnesota', 'Reye Syndrome'] | 4,022,381 | [['M01.060.057'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.107.567.875.350.510', 'Z01.107.567.875.510.510'], ['C06.552.241.649', 'C10.228.140.163.780', 'C18.452.132.780']] | ['Named Groups [M]', 'Organisms [B]', 'Geographicals [Z]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
An interesting molecular-assembly of â-cyclodextrin pipelines with embedded hydrophilic nickel maleonitriledithiolate. | A unique tubular molecular-assembly, constructed by â-cyclodextrin and Na[Ni(mnt)(2)], was identified by X-ray crystallography. Inclusion complex Na[Ni(mnt)(2)]@â-cyclodextrin (1) crystallized in space group P2(1)2(1)2 as hydrated head-to-head, tail-to-tail, and head-to-tail host pipelines with negatively charged [Ni(m... | ['Coordination Complexes', 'Crystallography, X-Ray', 'Hydrophobic and Hydrophilic Interactions', 'Molecular Conformation', 'Nickel', 'Quantum Theory', 'Sulfhydryl Compounds', 'beta-Cyclodextrins'] | 21,971,299 | [['D01.234', 'D02.257'], ['E05.196.309.742.225'], ['G02.409'], ['G02.111.570.820'], ['D01.268.556.607', 'D01.268.956.625', 'D01.552.544.607'], ['H01.671.579.800'], ['D02.886.489'], ['D04.345.103.333', 'D09.301.915.400.375.333', 'D09.698.365.855.400.375.333']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Robust information gain based fuzzy c-means clustering and classification of carotid artery ultrasound images. | In this paper, a robust method is proposed for segmentation of medical images by exploiting the concept of information gain. Medical images contain inherent noise due to imaging equipment, operating environment and patient movement during image acquisition. A robust medical image segmentation technique is thus inevitab... | ['Algorithms', 'Carotid Arteries', 'Carotid Intima-Media Thickness', 'Cluster Analysis', 'Fuzzy Logic', 'Humans', 'Neural Networks, Computer', 'Plaque, Atherosclerotic', 'Probability'] | 24,239,296 | [['G17.035', 'L01.224.050'], ['A07.015.114.186'], ['E01.370.350.850.150', 'E01.370.370.180', 'G09.330.210'], ['E05.318.740.250', 'N05.715.360.750.200', 'N06.850.520.830.250'], ['E05.599.250', 'K01.752.448.250', 'L01.224.050.375.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G17.485', 'L01.224.050.375.605'], ... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Humanities [K]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Treatment patterns, efficacy and toxicity of regorafenib in gastrointestinal stromal tumour patients. | Regorafenib was approved as third-line therapy for advanced Gastrointestinal Stromal Tumour (GIST) at a starting dose of 160 mg daily 3 weeks on, 1 week off, based on improvement in progression free survival over placebo (4.8 vs. 0.9 months), but the response rate was low at 4.5%. Given the high toxicity rate in GIST p... | ['Adult', 'Aged', 'Aged, 80 and over', 'Antineoplastic Agents', 'Female', 'Gastrointestinal Stromal Tumors', 'Humans', 'Male', 'Middle Aged', 'Phenylurea Compounds', "Practice Patterns, Physicians'", 'Pyridines', 'Survival Analysis', 'Treatment Outcome', 'Young Adult'] | 28,842,575 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.954.248'], ['C04.557.450.565.370', 'C06.301.371.308', 'C06.405.249.308'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['D02.065.950.681', 'D02.455.426.559.389.703'], ['N04.590.374.577', 'N05.300.625'], ['D03.383.725'], [... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Endoscopic management of a post-traumatic biliary fistula. | A number of techniques of surgical endoscopy have been used in the management of a post-traumatic biliary fistula. The endoscopic sphincterotomy with placement of a perfused nasobiliary catheter, followed by the insertion of a biliary stent allowed the fistula to dry out. A secondary stricture of the left hepatic duct ... | ['Adult', 'Biliary Fistula', 'Cholangiopancreatography, Endoscopic Retrograde', 'Drainage', 'Endoscopy', 'Humans', 'Male', 'Methods'] | 3,608,924 | [['M01.060.116'], ['C06.267.150', 'C23.300.575.185.150'], ['E01.370.350.700.715.200.200', 'E01.370.372.200.200', 'E01.370.372.250.200', 'E01.370.388.250.250.160', 'E04.210.240.160', 'E04.502.250.250.160'], ['E02.309', 'E04.237'], ['E01.370.388.250', 'E04.502.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Importin alpha nuclear localization signal binding sites for STAT1, STAT2, and influenza A virus nucleoprotein. | Proteins actively transported into the nucleus via the classical nuclear import pathway contain nuclear localization signals (NLSs), which are recognized by the family of importin alpha molecules. Importin alpha contains 10 armadillo (arm) repeats, of which the N-terminal arm repeats 2-4 have been considered as the "ma... | ['Amino Acid Sequence', 'Animals', 'Antigens, Polyomavirus Transforming', 'Baculoviridae', 'Binding Sites', 'Blotting, Western', 'Cell Line', 'DNA-Binding Proteins', 'Dimerization', 'Electrophoresis, Polyacrylamide Gel', 'Humans', 'Insecta', 'Interferons', 'Karyopherins', 'Models, Molecular', 'Molecular Sequence Data',... | 12,740,372 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D12.776.624.664.520.090', 'D12.776.964.700.090', 'D23.050.285.062.090', 'D23.050.327.062.090'], ['B04.280.065', 'B04.525.100'], ['G02.111.570.120'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['A11.251.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Tuberculosis and nontuberculous mycobacteriosis in patients with AIDS. | Thirty-six patients with AIDS and culture-proven nontuberculous mycobacteriosis were compared to 20 patients with acquired immunodeficiency syndrome (AIDS) and tuberculosis with regard to clinical signs, symptoms, and diagnostic methods. Patients with nontuberculous mycobacteriosis were more often younger and homosexua... | ['Acquired Immunodeficiency Syndrome', 'Adult', 'Age Factors', 'Bronchoscopy', 'Female', 'Haiti', 'Homosexuality', 'Humans', 'Male', 'Mycobacterium Infections', 'Mycobacterium Infections, Nontuberculous', 'Opportunistic Infections', 'Risk Factors', 'Sputum', 'Substance-Related Disorders', 'Tuberculosis, Pulmonary', 'Un... | 3,349,832 | [['C01.221.250.875.040', 'C01.221.812.640.400.040', 'C01.778.640.400.040', 'C01.925.782.815.616.400.040', 'C01.925.813.400.040', 'C01.925.839.040', 'C20.673.480.040'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['E01.370.386.105', 'E01.370.388.250.100', 'E04.502.250.100', 'E04.928.600.080'], ['Z01.107.084... | ['Diseases [C]', 'Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
MPF components and meiotic competence in growing pig oocytes. | Growing pig oocytes (< or = 90 microns in diameter) are unable to resume meiosis in vitro. The objective of our present experiments has been to identify the reasons for meiotic competence in these cells. By comparing histone H1 kinase activity in growing and fully grown oocytes we demonstrate that incompetence is assoc... | ['Animals', 'CDC2 Protein Kinase', 'Cell Cycle', 'Cyclins', 'Ethers, Cyclic', 'Female', 'G2 Phase', 'In Vitro Techniques', 'Maturation-Promoting Factor', 'Meiosis', 'Mitosis', 'Okadaic Acid', 'Oocytes', 'Oogenesis', 'Phosphoprotein Phosphatases', 'Protamine Kinase', 'Protein Phosphatase 1', 'Swine'] | 8,049,069 | [['B01.050'], ['D08.811.913.696.620.682.700.646.500.500.250', 'D08.811.913.696.620.682.700.646.500.984.500', 'D12.644.360.250.067.249', 'D12.644.360.250.580.500', 'D12.776.167.200.067.249', 'D12.776.167.200.580.500', 'D12.776.476.250.067.249', 'D12.776.476.250.580.500', 'D12.776.744.360'], ['G04.144'], ['D12.644.360.26... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Adverse effects & drug load of antiepileptic drugs in patients with epilepsy: Monotherapy versus polytherapy. | BACKGROUND & OBJECTIVES: Although the need for a combination of antiepileptic drugs (AEDs) in the treatment of epilepsy is well justified, but an associated increase in adverse effects (AEs) lends a restriction to polytherapy. The aim of this study was to evaluate AEs and drug load (prescribed daily dose/defined daily ... | ['Adolescent', 'Adult', 'Anticonvulsants', 'Drug Therapy, Combination', 'Drug-Related Side Effects and Adverse Reactions', 'Epilepsy', 'Female', 'Humans', 'India', 'Male', 'Middle Aged', 'Seizures'] | 28,749,393 | [['M01.060.057'], ['M01.060.116'], ['D27.505.954.427.080'], ['E02.319.310'], ['C25.100'], ['C10.228.140.490'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.245.393'], ['M01.060.116.630'], ['C10.597.742', 'C23.888.592.742']] | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
Randomized Trial Comparing Proactive, High-Dose versus Reactive, Low-Dose Intravenous Iron Supplementation in Hemodialysis (PIVOTAL): Study Design and Baseline Data. | BACKGROUND: Intravenous (IV) iron supplementation is a standard maintenance treatment for hemodialysis (HD) patients, but the optimum dosing regimen is unknown.METHODS: PIVOTAL (Proactive IV irOn Therapy in hemodiALysis patients) is a multicenter, open-label, blinded endpoint, randomized controlled (PROBE) trial. Incid... | ['Administration, Intravenous', 'Aged', 'Anemia, Iron-Deficiency', 'Dose-Response Relationship, Drug', 'Female', 'Ferric Oxide, Saccharated', 'Ferritins', 'Follow-Up Studies', 'Hematinics', 'Humans', 'Kidney Failure, Chronic', 'Male', 'Middle Aged', 'Prospective Studies', 'Renal Dialysis', 'Thrombosis', 'Treatment Outc... | 30,304,714 | [['E02.319.267.082'], ['M01.060.116.100'], ['C15.378.071.196.300', 'C18.452.565.100'], ['G07.690.773.875', 'G07.690.936.500'], ['D01.490.100.150', 'D02.241.081.844.300.500', 'D02.241.511.902.300.500', 'D09.811.295.500'], ['D12.776.157.427.249', 'D12.776.556.579.249'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.75... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A multidisciplinary group programme in rural settings for community-dwelling chronic stroke survivors and their carers: a pilot randomized controlled trial. | OBJECTIVES: To explore whether a group programme for community-dwelling chronic stroke survivors and their carers is feasible in rural settings; to measure the impact of the programme on health-related quality of life and functional performance; and to determine if any benefits gained are maintained.DESIGN: Randomized,... | ['Aged', 'Australia', 'Caregivers', 'Cross-Over Studies', 'Disability Evaluation', 'Female', 'Humans', 'Male', 'Motor Activity', 'Patient Care Team', 'Patient Education as Topic', 'Pilot Projects', 'Quality of Life', 'Rural Health Services', 'Rural Population', 'Self Care', 'Single-Blind Method', 'Stroke Rehabilitation... | 20,176,772 | [['M01.060.116.100'], ['Z01.639.100', 'Z01.678.100.373'], ['M01.085', 'M01.526.485.200', 'N02.360.200'], ['E05.318.370.150', 'N05.715.360.325.150', 'N06.850.520.445.150'], ['E01.370.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.632', 'G11.427.410.698'], ['N04.590.715'], ['I02.233.332.500', 'N02.421.... | ['Named Groups [M]', 'Geographicals [Z]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Disciplines and Occupat... | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Key factors associated with social distress after prostate cancer: Results from the United Kingdom Life after Prostate Cancer diagnosis study. | BACKGROUND: More men are living following a prostate cancer (PCa) diagnosis. They may need support to maximize the quality of their survival. Physical and psychological impacts of PCa are widely documented. Less is known about social impacts. We aimed to identify key factors associated with social distress following PC... | ['Aged', 'Cross-Sectional Studies', 'Humans', 'Male', 'Middle Aged', 'Prostatic Neoplasms', 'Quality of Life', 'Social Environment'] | 31,071,525 | [['M01.060.116.100'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C04.588.945.440.770', 'C12.294.260.750', 'C12.294.565.625', 'C12.758.409.750'], ['I01.800', 'K01.752.400.750', 'N06.850.505.400.425.837'], ['I01.88... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Food choice in the laboratory pigeon. | Although food reward plays a large role in learning and behavioral experiments, there have been few studies examining the most motivating food reward for pigeons. Brown (1969) found that pigeons had a tendency to prefer peas, while Killeen et al. (1993) found pigeons to prefer peas and popcorn in Experiment 1A. We look... | ['Animals', 'Choice Behavior', 'Columbidae', 'Eating', 'Food Preferences', 'Reward'] | 22,750,307 | [['B01.050'], ['F02.463.785.373.346'], ['B01.050.150.900.248.165.150'], ['G07.203.650.283', 'G10.261.330'], ['F01.145.407.516', 'G07.203.650.353.516'], ['F02.463.425.770.836']] | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Morphological studies on antibacterial activities of cefotiam (author's transl)]. | 1. Cefotiam was demonstrated to be more potent than cefazolin in its antibacterial activities against clinical isolates of E. coli, Klebsiella, Serratia, Proteus mirabilis, Proteus morganii and Proteus inconstans. MICs of cefotiam with 10(6) cells/ml inoculum size were considerably lower than those with 10(8) cells/ml.... | ['Cefazolin', 'Enterobacteriaceae', 'Escherichia coli', 'Klebsiella', 'Proteus', 'Serratia'] | 379,387 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Accumulation of pericardial fat correlates with left ventricular diastolic dysfunction in patients with normal ejection fraction. | BACKGROUND: Left ventricular diastolic dysfunction (LVDD) plays an important role in heart failure with normal left ventricular ejection fraction (LVEF). Obesity is one of the major comorbid conditions of LVDD. Pericardial fat (PF) is an ectopic fat depot with possible paracrine or mechanical effects on the coronary ci... | ['Adipose Tissue', 'Aged', 'Diastole', 'Echocardiography', 'Female', 'Heart Failure', 'Humans', 'Male', 'Middle Aged', 'Pericardium', 'Risk Factors', 'Stroke Volume', 'Tomography, X-Ray Computed', 'Ventricular Dysfunction, Left'] | 22,365,950 | [['A10.165.114'], ['M01.060.116.100'], ['G09.330.580.295', 'G11.427.494.554.250', 'G11.427.494.570.295'], ['E01.370.350.130.750', 'E01.370.350.850.220', 'E01.370.370.380.220'], ['C14.280.434'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['A07.541.795', 'A10.615.789.470'], ['E05.318.740.600.80... | ['Anatomy [A]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Modulation of Cyclodextrin Particle Amphiphilic Properties to Stabilize Pickering Emulsion. | Cyclodextrins have been proven to form complexes with linear oil molecules and stabilize emulsions. Amphiphilic properties of cyclodextrin particles were modulated through esterification reaction between â-cyclodextrin (â-CD) and octadecenyl succinic anhydride (ODSA) under alkaline conditions. ODS-â-CD particles with d... | ['Emulsions', 'Hydrogen-Ion Concentration', 'Hydrophobic and Hydrophilic Interactions', 'Particle Size', 'beta-Cyclodextrins'] | 29,251,505 | [['D20.280.260', 'D26.255.165.260'], ['G02.300'], ['G02.409'], ['G02.712'], ['D04.345.103.333', 'D09.301.915.400.375.333', 'D09.698.365.855.400.375.333']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A pyrolysis study for the thermal and kinetic characteristics of an agricultural waste with two different plastic wastes. | In this study, thermochemical conversion of plastic wastes (PET and PVC) together with an agricultural waste (hazelnut shell) was investigated. In order to determine the thermal and kinetic behaviours, pyrolysis experiments were carried out from room temperature to 800 °C, with a heating rate of 10 °C min(-1) in the pr... | ['Agriculture', 'Corylus', 'Incineration', 'Industrial Waste', 'Kinetics', 'Polyethylene Terephthalates', 'Polyvinyl Chloride', 'Thermogravimetry'] | 25,062,939 | [['J01.040'], ['B01.650.940.800.575.912.250.859.750.200.875'], ['N06.850.860.510.900.600.500'], ['D20.944.420', 'N06.850.460.710.420'], ['G01.374.661', 'G02.111.490'], ['D05.750.728.764', 'D25.720.728.764', 'J01.637.051.720.728.764'], ['D02.455.326.271.884.533.565', 'D05.750.716.721.812', 'D25.720.327.811', 'D25.720.71... | ['Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Enhanced growth inhibition of hepatic multicellular tumor spheroids by lactosylated poly(ethylene glycol)-siRNA conjugate formulated in PEGylated polyplexes. | PEGylated polyplexes (lac-PEGylated polyplexes) composed of poly(L-lysine) and lactosylated poly(ethylene glycol)-small interfering RNA conjugate, which inhibits the RecQL1 gene product, were revealed to show an appreciable growth inhibition of multicellular HuH-7 spheroids (human hepatocarcinoma cell lines) for up to ... | ['Antineoplastic Agents', 'Cell Division', 'Humans', 'Lactose', 'Liver Neoplasms', 'Molecular Structure', 'Polyethylene Glycols', 'RNA, Small Interfering', 'Tumor Cells, Cultured'] | 17,546,711 | [['D27.505.954.248'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D09.698.629.305.340', 'D09.947.750.340'], ['C04.588.274.623', 'C06.301.623', 'C06.552.697'], ['G02.111.570', 'G02.466'], ['D02.033.455.250.700', 'D05.750.741', 'D25.720.741'... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Epidemiology and outcomes of acute Achilles tendon rupture with operative or nonoperative treatment using an identical functional bracing protocol. | BACKGROUND: This study reports on the demographics of acute Achilles tendon rupture in our region and compares the results of a selective approach to operative and nonoperative treatment using an identical rehabilitation program with functional bracing.MATERIALS AND METHODS: A consecutive series of 363 patients, aged 1... | ['Achilles Tendon', 'Adolescent', 'Adult', 'Athletic Injuries', 'Braces', 'Female', 'Humans', 'Incidence', 'Male', 'Middle Aged', 'New Zealand', 'Postoperative Complications', 'Rupture', 'Tendon Injuries', 'Treatment Outcome', 'Young Adult'] | 21,733,434 | [['A02.880.176'], ['M01.060.057'], ['M01.060.116'], ['C26.115'], ['E07.858.442.743.319'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.985.525.375'], ['M01.060.116.630'], ['Z01.639.760.747', 'Z01.678.100.747'], ['C23.... | ['Anatomy [A]', 'Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Geographicals [Z]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Production of 4-methylumbelliferyl heptanoate hydrolase by Escherichia coli exposed to seawater. | The production of an enzyme, 4-methylumbelliferyl heptanoate hydrolase, in Escherichia coli exposed to enriched and nonenriched seawater was studied. In all media, except for seawater with no or very small amounts of organic material and seawater enriched with peptone, 4-methylumbelliferyl heptanoate hydrolase activity... | ['Colony Count, Microbial', 'Culture Media', 'Escherichia coli', 'Hydrolases', 'Hymecromone', 'Seawater', 'Umbelliferones', 'Water Microbiology'] | 2,679,388 | [['E01.370.225.875.220', 'E05.200.875.220'], ['D27.720.470.305', 'E07.206'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D08.811.277'], ['D03.383.663.283.446.912.531', 'D03.633.100.150.446.912.531'], ['G16.500.275.725.500'], ['D03.383.663.283.446.912', 'D03.633.100.150.446.912'], ['H01.158.273.540.274.777... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Interview with Alberto Zanchetti, MD. | This month, The Journal of Clinical Hypertension features a hypertension icon from outside of the United States. Professor Alberto Zanchetti of Milan, Italy has been one of the most prominent researchers and teachers in the field of hypertension in Europe for the past 40 years. Those of us who have attended the Europea... | ['Antihypertensive Agents', 'Blood Pressure', 'Humans', 'Hypertension', 'International Cooperation', 'Italy', 'Male', 'Practice Guidelines as Topic'] | 15,860,964 | [['D27.505.954.411.162'], ['E01.370.600.875.249', 'G09.330.380.076'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['I01.615.500'], ['Z01.542.489'], ['N04.761.700.350.650', 'N05.700.350.650']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
[Heparin-induced thrombocytopenia in patients
undergoing cardiac surgery]. | OBJECTIVE: To investigate the incidence for heparin-induced thrombocytopenia (HIT) in patients undergoing cardiac surgery and to evaluate the risk factors for the generation of HIT-antibody.
METHODS: A total of 315 patients undergoing cardiac surgery in the Department of Cardiothoracic Surgery, Xiangya Hospital between... | ['Antibodies', 'Cardiac Surgical Procedures', 'Cardiopulmonary Bypass', 'Coronary Artery Bypass', 'Female', 'Heparin', 'Humans', 'Incidence', 'Male', 'Platelet Count', 'Platelet Factor 4', 'Postoperative Complications', 'Risk Factors', 'Thrombocytopenia'] | 26,267,693 | [['D12.776.124.486.485.114', 'D12.776.124.790.651.114', 'D12.776.377.715.548.114'], ['E04.100.376', 'E04.928.220'], ['E04.292.413'], ['E04.100.376.719.332', 'E04.100.814.868.750', 'E04.928.220.520.220'], ['D09.698.373.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.5... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Choroideremia: linkage analysis with physically mapped close DNA-markers. | We report linkage studies in 18 choroideremia (TCD) families using four closely linked polymorphic markers. Probe pZ11, which is known to be deleted in several unrelated patients with TCD, showed no recombinations (zeta max 15.63 at theta = 0.00). In contrast, one recombination was observed with DXS367, which is also p... | ['Choroideremia', 'DNA Probes', 'Female', 'Genetic Linkage', 'Humans', 'Lod Score', 'Male', 'Pedigree', 'Polymorphism, Restriction Fragment Length', 'X Chromosome'] | 1,677,924 | [['C11.270.142', 'C11.941.160.300', 'C16.320.290.142', 'C16.320.322.092'], ['D13.444.600.223', 'D27.505.259.750.600.223', 'D27.720.470.530.600.223'], ['G05.348'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G05.348.750'], ['E05.393.673'], ['G05.365.795.595'], ['A11.284.187.865.982', 'G05.360.162.865.982']] | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The ureterovesical junction. | The ureterovesical junction was studied by dissection and serial sections in 50 post mortem specimens. Three points are considered in this paper: the structure of the terminal ureter, the anatomical arrangement of the ureteral hiatus and the ureteral sheath. Study of the structure of the intramural segment of the urete... | ['Adolescent', 'Adult', 'Child', 'Child, Preschool', 'Diverticulum', 'Elastic Tissue', 'Humans', 'Infant', 'Infant, Newborn', 'Muscle, Smooth', 'Ureter', 'Urinary Bladder', 'Vesico-Ureteral Reflux'] | 6,426,491 | [['M01.060.057'], ['M01.060.116'], ['M01.060.406'], ['M01.060.406.448'], ['C06.405.205.282.750', 'C23.300.415'], ['A10.165.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['A02.633.570', 'A10.690.467'], ['A05.810.776'], ['A05.810.890'], ['C12.777.829.920', 'C13.351.968.829.... | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Reversed-phase HPLC separation of human serum employing a novel saw-tooth gradient: toward multidimensional proteome analysis. | A novel reversed-phase (RP-) HPLC gradient profile applicable to multidimensional separations of complex protein mixtures is reported. This gradient profile elutes small numbers of proteins from the RP-HPLC column in discrete intervals while minimizing the amount of band broadening between elution intervals and maintai... | ['Blood Proteins', 'Chromatography, High Pressure Liquid', 'Humans', 'Molecular Weight', 'Proteomics'] | 15,595,723 | [['D12.776.124'], ['E05.196.181.400.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.494'], ['H01.158.201.843', 'H01.158.273.180.350.700', 'H01.158.273.343.350.700', 'H01.181.122.738']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Organocatalytic highly enantioselective nitroaldol reaction of alpha-ketophosphonates and nitromethane. | [reaction: see text] The first organocatalytic highly enantioselective nitroaldol reaction of alpha-ketophosphonates and nitromethane has been realized by using cupreine (2) or 9-O-benzylcupreine (3) as the catalyst. Both catalysts are highly reactive and highly enantioselective. alpha-Hydroxy-beta-nitrophosphonates ha... | ['Catalysis', 'Methane', 'Molecular Structure', 'Nitrogen', 'Nitroparaffins', 'Phosphorus', 'Stereoisomerism'] | 17,284,048 | [['G02.130'], ['D02.455.326.146.571'], ['G02.111.570', 'G02.466'], ['D01.268.604', 'D01.362.625'], ['D02.455.326.146.672', 'D02.640.720'], ['D01.268.666'], ['G02.607.445.682']] | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Treatment with acarbose, an alpha-glucosidase inhibitor, reduces increased albumin excretion in streptozotocin-diabetic rats. | 1. We examined the effect of the alpha-glucosidase inhibitor acarbose on urinary albumin excretion (UAE) in streptozotocin diabetic rats. 2. Treatment with acarbose for 8 weeks after induction of diabetes prevented the significant increase in UAE observed in untreated diabetic rats relative to nondiabetic controls. 3. ... | ['Acarbose', 'Albuminuria', 'Animals', 'Blood Glucose', 'Diabetes Mellitus, Experimental', 'Disease Models, Animal', 'Enzyme Inhibitors', 'Glucosidases', 'Male', 'Rats', 'Rats, Wistar', 'Streptozocin', 'Time Factors', 'Trisaccharides'] | 7,590,131 | [['D09.698.629.802.100'], ['C12.777.934.734.269', 'C13.351.968.934.734.269', 'C23.888.942.750.269'], ['B01.050'], ['D09.947.875.359.448.500'], ['C18.452.394.750.074', 'C19.246.240', 'E05.598.500.374'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['D27.505.519.389'], ['D08.811.277.450.420'], ['B01.050.150.900.649.313... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Adaptation of gastrointestinal nematode parasites to host genotype: single locus simulation models. | BACKGROUND: Breeding livestock for improved resistance to disease is an increasingly important selection goal. However, the risk of pathogens adapting to livestock bred for improved disease resistance is difficult to quantify. Here, we explore the possibility of gastrointestinal worms adapting to sheep bred for low fae... | ['Adaptation, Biological', 'Algorithms', 'Alleles', 'Animals', 'Biological Evolution', 'Computer Simulation', 'Female', 'Gene Frequency', 'Genetic Fitness', 'Genetic Loci', 'Genetic Variation', 'Genotype', 'Host-Pathogen Interactions', 'Intestinal Diseases, Parasitic', 'Male', 'Models, Biological', 'Nematoda', 'Parasit... | 23,714,384 | [['G16.012'], ['G17.035', 'L01.224.050'], ['G05.360.340.024.340.030'], ['B01.050'], ['G05.045', 'G16.075'], ['L01.224.160'], ['G05.330'], ['G05.347'], ['G05.360.340.024.380'], ['G05.365'], ['G05.380'], ['G06.462', 'G16.527.200'], ['C01.610.432', 'C06.405.469.452'], ['E05.599.395'], ['B01.050.500.500.294'], ['E01.370.22... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
High-dose methotrexate therapy. | Eighty-six adults with malignant disease were given high doses of methotrexate with folinic acid rescue, with acceptable toxicity. Protocal violations in two cases led to death. The results of therapy in some diagnostic groups are encouraging. | ['Adult', 'Carcinoma, Squamous Cell', 'Drug Therapy, Combination', 'Head and Neck Neoplasms', 'Humans', 'Leucovorin', 'Lymphoma', 'Methotrexate', 'Neoplasms'] | 300,460 | [['M01.060.116'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['E02.319.310'], ['C04.588.443'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.633.100.733.631.400.800.350.450', 'D08.211.840.300.500'], ['C04.557.386', 'C15.604.515.569', 'C20.683.515.761'], ['D03.633.100.733.631.192.500'], ['C04']] | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Stereoselective synthesis of the naturally occurring styryllactones (+)-goniofufurone and (+)-cardiobutanolide. | The naturally occurring gamma-lactones (+)-goniofufurone 1 and (+)-cardiobutanolide 2, two pharmacologically active products from Goniothalamus species (Annonaceae), have been synthesized in enantiopure form using l-erythrulose as the chiral starting material. Key steps of these syntheses were a stereoselective anti bo... | ['4-Butyrolactone', 'Annonaceae', 'Glycerol', 'Lactones', 'Magnetic Resonance Spectroscopy', 'Molecular Structure', 'Stereoisomerism'] | 15,651,827 | [['D02.540.150', 'D03.383.312.150'], ['B01.650.940.800.575.912.250.065'], ['D02.033.800.875.500', 'D09.853.875.500'], ['D02.540'], ['E05.196.867.519'], ['G02.111.570', 'G02.466'], ['G02.607.445.682']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Site-specific PEGylation of a lysine-deficient TNF-alpha with full bioactivity. | Addition of polyethylene glycol to protein (PEGylation) to improve stability and other characteristics is mostly nonspecific and may occur at all lysine residues, some of which may be within or near an active site. Resultant PEGylated proteins are heterogeneous and can show markedly lower bioactivity. We attempted to d... | ['Animals', 'BALB 3T3 Cells', 'Binding Sites', 'Female', 'Fibrosarcoma', 'Humans', 'Lysine', 'Macromolecular Substances', 'Mice', 'Mutagenesis, Site-Directed', 'Peptide Library', 'Polyethylene Glycols', 'Protein Binding', 'Protein Engineering', 'Tumor Necrosis Factor-alpha'] | 12,665,803 | [['B01.050'], ['A11.251.210.100.080', 'A11.329.228.100.080'], ['G02.111.570.120'], ['C04.557.450.565.590.350', 'C04.557.450.795.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.125.068.555', 'D12.125.095.647', 'D12.125.142.497'], ['D05'], ['B01.050.150.900.649.313.992.635.505.500'], ['E05.393.420.601.575']... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Highly resilient coping entails better perceived health, high social support and low morning cortisol levels in parents of children with autism spectrum disorder. | The negative consequences of caring for people with developmental disabilities have been widely described. However, the ability to bounce back from the stress derived from care situations has been less studied. Those caregivers who have shown this ability are considered as resilient. This study aims to evaluate the rel... | ['Adaptation, Psychological', 'Adolescent', 'Adult', 'Child', 'Child Development Disorders, Pervasive', 'Female', 'Health Status', 'Humans', 'Hydrocortisone', 'Life Change Events', 'Male', 'Middle Aged', 'Parents', 'Resilience, Psychological', 'Saliva', 'Social Support', 'Stress, Psychological', 'Surveys and Questionna... | 24,405,793 | [['F01.058'], ['M01.060.057'], ['M01.060.116'], ['M01.060.406'], ['F03.625.164'], ['I01.240.425', 'N01.224.425', 'N06.850.505.400.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D04.210.500.745.745.654.600', 'D06.472.040.585.353.476', 'D06.472.040.585.478.392'], ['F01.829.458.410'], ['M01.060.116.630'], ['F01... | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Modulating protein structure with fluorous amino acids: increased stability and native-like structure conferred on a 4-helix bundle protein by hexafluoroleucine. | There has recently been much interest in exploiting the unusual properties associated with fluorocarbons to modulate the physicochemical properties of proteins. Here we present a detailed investigation into the effect on structure and stability of systematically repacking the hydrophobic core of a model protein with th... | ['Amino Acid Sequence', 'Leucine', 'Models, Molecular', 'Molecular Sequence Data', 'Nuclear Magnetic Resonance, Biomolecular', 'Peptides', 'Protein Denaturation', 'Protein Folding', 'Protein Structure, Secondary', 'Ultracentrifugation'] | 16,390,163 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D12.125.070.637', 'D12.125.142.441'], ['E05.599.595'], ['L01.453.245.667'], ['E05.196.867.519.550'], ['D12.644'], ['G01.154.651.750.500', 'G02.111.688.750.500'], ['G01.154.651', 'G02.111.688'], ['G02.111.570.820.709.600'], ['E05.181.724', 'E05.196.941']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Effects of methyl substitutions on benz[a]anthracene derivatives-induced immunosuppression. | Polycyclic aromatic hydrocarbons are ubiquitous environmental contaminants known to be carcinogenic as well as immunosuppressive. Structure-activity studies have demonstrated that modifications in the number of methyl groups of benzanthracenic compounds lead to major changes in their biological activities such as induc... | ['9,10-Dimethyl-1,2-benzanthracene', 'Animals', 'Antibodies, Monoclonal', 'Benz(a)Anthracenes', 'CD3 Complex', 'Carcinogens', 'Cell Cycle', 'Cell Division', 'Concanavalin A', 'Female', 'Immunosuppressive Agents', 'Interleukin-1', 'Interleukin-2', 'Interleukin-6', 'Lethal Dose 50', 'Methylation', 'Mice', 'Mice, Inbred C... | 8,931,739 | [['D02.455.426.559.847.149.301', 'D04.615.149.301'], ['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D02.455.426.559.847.149', 'D04.615.149'], ['D23.050.301.264.894.095', 'D23.101.100.894.095'], ['D27.888.569.100'], ['G04.144'], ['G04.144.220', 'G04.161.750.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Production of the angiotensin converting enzyme (ACE) in cultures of rat peritoneal macrophages. | Some authors attributed an increase in ACE activity in sarcoidosis to high production of this enzyme by alveolar macrophages. In order to study the production of ACE by peritoneal rat macrophages, we measured the ACE activity, by a modified version of Friedland and Silverstein's technique, in cultures of rat peritoneal... | ['Animals', 'Cell Count', 'Cell Survival', 'Cells, Cultured', 'Dexamethasone', 'Female', 'Macrophages', 'Male', 'Peptidyl-Dipeptidase A', 'Peritoneal Cavity', 'Rats', 'Rats, Inbred Strains', 'Sarcoidosis'] | 3,033,786 | [['B01.050'], ['E01.370.225.500.195', 'E05.200.500.195', 'E05.242.195', 'G04.140'], ['G04.346'], ['A11.251'], ['D04.210.500.745.432.769.344', 'D04.210.500.908.238'], ['A11.329.372', 'A11.627.482', 'A11.733.397', 'A15.382.670.522', 'A15.382.680.397'], ['D08.811.277.656.350.350.687'], ['A01.923.047.025.600.678'], ['B01.0... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Structural and functional changes in left ventricle during normotensive and preeclamptic pregnancy. | Increased cardiac output in pregnancy is associated with cardiac remodeling and possible reduction in contractility, which may worsen in preeclampsia. Left ventricular (LV) geometry and function were compared between nonpregnant controls (n = 12) and normotensive (n = 44) and preeclamptic (n = 15) pregnant women using ... | ['Adult', 'Blood Pressure', 'Echocardiography', 'Female', 'Humans', 'Hypertension', 'Hypertrophy, Left Ventricular', 'Pre-Eclampsia', 'Pregnancy', 'Ventricular Function, Left'] | 12,234,817 | [['M01.060.116'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E01.370.350.130.750', 'E01.370.350.850.220', 'E01.370.370.380.220'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['C14.280.195.400', 'C23.300.775.250.400'], ['C13.703.395.249'], ['G08.686.784.769'], ['G09.330.955.800']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A Very Unlucky Intraoperative Event During a Chimney Technique for Juxtarenal Aneurysm Exclusion. | A two-vessel Ch-EVAR procedure was scheduled within the instructions for use of the devices. After deploying, it appeared that the long sheath inserted through an arm access was discovered to be trapped behind the aortic stentgraft barbs. Trying to remove the sheath, the graft was displaced upward and the procedure was... | ['Aged, 80 and over', 'Angioplasty, Balloon', 'Aortic Aneurysm', 'Blood Vessel Prosthesis Implantation', 'Endovascular Procedures', 'Fluoroscopy', 'Humans', 'Intraoperative Complications', 'Male', 'Prosthesis Design', 'Renal Artery', 'Stents', 'Time Factors', 'Tomography, X-Ray Computed', 'Treatment Outcome'] | 30,843,094 | [['M01.060.116.100.080'], ['E02.148.050.060', 'E04.100.814.529.124.060', 'E04.502.382.124.060', 'E05.157.016.060'], ['C14.907.055.239', 'C14.907.109.139'], ['E04.100.814.868.500', 'E04.650.200'], ['E04.100.814.529', 'E04.502.382'], ['E01.370.350.700.225'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.505'... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Intraflagellar Transport Complex A Genes Differentially Regulate Cilium Formation and Transition Zone Gating. | Cilia are found on most eukaryotic cell types, serving motility, environment sensing, and signaling (cell-cell) functions, and defects cause genetic diseases (ciliopathies), affecting the development of many tissues [1]. Cilia are built by intraflagellar transport (IFT), a bidirectional microtubule-based motility drive... | ['Animals', 'Biological Transport', 'Caenorhabditis elegans', 'Caenorhabditis elegans Proteins', 'Cilia', 'Genes, Helminth'] | 30,293,716 | [['B01.050'], ['G03.143'], ['B01.050.500.500.294.400.875.660.250.250'], ['D12.776.419.500'], ['A11.284.180.165'], ['G05.360.340.024.340.310', 'G05.360.340.337.500']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vitamin D status in a group of Spanish schoolchildren. | AIM: The aim was to determine the vitamin D status of a group of Spanish schoolchildren in order to help in the design of campaigns to prevent vitamin D deficiency in this subpopulation.METHODS: This was a cross-sectional observational study, carried out in schools in Madrid (Spain), during 2007-2008. The study enrolle... | ['Adolescent', 'Algorithms', 'Calcifediol', 'Child', 'Cross-Sectional Studies', 'Dietary Supplements', 'Eating', 'Female', 'Humans', 'Male', 'Motor Activity', 'Nutrition Surveys', 'Schools', 'Spain', 'Students', 'Surveys and Questionnaires', 'Vitamin D Deficiency', 'Vitamins'] | 21,311,425 | [['M01.060.057'], ['G17.035', 'L01.224.050'], ['D04.210.500.247.222.159.478.250', 'D04.210.500.247.808.146.478.250', 'D04.210.500.812.768.196.478.250', 'D10.570.938.146.478.250'], ['M01.060.406'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['G07.203.300.456', 'J02.500.456'], ['G07.20... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, So... | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 |
Impact of dissolved organic matter on mercury and methylmercury sorption to activated carbon in soils: implications for remediation. | Activated carbon (AC) amendments have shown promise in reducing inorganic mercury (Hg(ii) complexes, "Hg") and methylmercury (MeHg) risk in contaminated soils. However, the effectiveness of AC in Hg and MeHg immobilization has varied among studies, suggesting that site biogeochemistry might dictate efficacy. In this st... | ['Biodegradation, Environmental', 'Charcoal', 'Humic Substances', 'Mercury', 'Methylmercury Compounds', 'Rivers', 'Soil', 'Sulfides', 'Water Pollutants, Chemical'] | 30,724,289 | [['N06.230.080.600.500', 'N06.850.460.375.500'], ['D01.268.150.150'], ['D02.241.444', 'D02.455.426.559.389.657.377', 'D20.721.500'], ['D01.268.556.504', 'D01.268.956.437', 'D01.552.544.504'], ['D02.691.750.100.738'], ['G01.311.750', 'G16.500.275.280.650', 'N06.230.232.650'], ['D20.721', 'G01.311.820', 'G16.500.275.815'... | ['Health Care [N]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Storage stability of Anagrapha falcifera nucleopolyhedrovirus in spray-dried formulations. | A multiply embedded nucleopolyhedrovirus isolated from Anagrapha falcifera (Kirby) (AfMNPV) can lose insecticidal activity during months of dry storage in ambient room conditions. We tested the spray-dried AfMNPV formulations after storage for up to 1 year at room temperatures for insecticidal activity against neonate ... | ['Animals', 'Moths', 'Nucleopolyhedroviruses', 'Pest Control, Biological'] | 12,054,782 | [['B01.050'], ['B01.050.500.131.617.720.500.500.937.650'], ['B04.280.065.500', 'B04.525.100.500'], ['N06.850.780.200.650.650']] | ['Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[Laparoscopy in surgical planning]. | On the basis of the results of examination of 152 patients, the authors came to conclusion that laparoscopy permitted to specify the type and volume of an operative intervention, to choose the rational tactics of treatment. In gas introduction into the gastric lumen, the survey of the difficult to access sites improved... | ['Diagnosis, Differential', 'Humans', 'Laparoscopy', 'Peptic Ulcer', 'Preoperative Care', 'Stomach Neoplasms'] | 2,525,637 | [['E01.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.388.250.520', 'E04.502.250.520'], ['C06.405.469.275.800', 'C06.405.748.586'], ['E02.760.795', 'E04.604.750', 'N02.421.585.795'], ['C04.588.274.476.767', 'C06.301.371.767', 'C06.405.249.767', 'C06.405.748.789']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Transfusion-related acute lung injury following PDA ligation in a preterm neonate. | Transfusion-related acute lung injury (TRALI) is a life-threatening complication of blood product transfusion characterized by sudden onset hypoxemic respiratory failure with bilateral lung infiltrates and non-cardiogenic pulmonary edema developing within 6 hours of transfusion. It is believed to be under-recognized, p... | ['Anemia', 'Ductus Arteriosus, Patent', 'Erythrocyte Transfusion', 'Female', 'High-Frequency Ventilation', 'Humans', 'Infant, Extremely Premature', 'Infant, Newborn', 'Postoperative Complications', 'Pulmonary Edema', 'Radiography, Thoracic', 'Transfusion-Related Acute Lung Injury'] | 28,854,506 | [['C15.378.071'], ['C14.240.400.340', 'C14.280.400.340', 'C16.131.240.400.340'], ['E02.095.135.140.275'], ['E02.041.625.508', 'E02.880.820.508'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520.520.500'], ['M01.060.703.520'], ['C23.550.767'], ['C08.381.742'], ['E01.370.350.700.730'], ['C08.381.520.50... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Elevated skin tissue cholesterol levels and myocardial infarction. | BACKGROUND: Skin cholesterol has been associated with coronary artery disease, extent of angiographic disease and inflammatory markers such as hs-CRP. Based on these findings we sought to determine whether skin cholesterol was associated with myocardial infarction (MI).METHODS: Patients (N = 649) underwent diagnostic c... | ['Aged', 'Cholesterol', 'Coronary Angiography', 'Female', 'Humans', 'Male', 'Middle Aged', 'Myocardial Infarction', 'Risk Factors', 'Skin'] | 16,039,292 | [['M01.060.116.100'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['E01.370.350.130.625', 'E01.370.350.700.060.200', 'E01.370.370.050.200', 'E01.370.370.380.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C14.280.647.500', 'C14.907.585.500', 'C23.550.513.355... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Differential reactivity to IMPDH2 by anti-rods/rings autoantibodies and unresponsiveness to pegylated interferon-alpha/ribavirin therapy in US and Italian HCV patients. | PURPOSE: Autoantibodies to cytoplasmic structures called rods and rings (RR) are primarily specific to patients with hepatitis C virus (HCV) infection treated with pegylated interferon-alpha/ribavirin (IFN/R). Our aim is to examine anti-RR antibodies specificity and correlation with the response to IFN/R therapy in two... | ['Antibody Specificity', 'Antiviral Agents', 'Autoantibodies', 'Cohort Studies', 'Hepatitis C', 'Humans', 'IMP Dehydrogenase', 'Interferon-alpha', 'Italy', 'Polyethylene Glycols', 'Recombinant Proteins', 'Ribavirin', 'Seroepidemiologic Studies', 'Treatment Outcome', 'United States'] | 23,100,146 | [['G12.100'], ['D27.505.954.122.388'], ['D12.776.124.486.485.114.323', 'D12.776.124.790.651.114.323', 'D12.776.377.715.548.114.323'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['C01.221.250.750', 'C01.925.440.440', 'C01.925.782.350.350', 'C06.552.380.705.440'], ['B01.050.150.900.649... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
Modified injury severity scale and concurrent steroid therapy: independent correlates of negative nitrogen balance in pediatric trauma. | Twelve well-nourished children with multiple trauma were separately grouped by the presence or absence of a head injury and associated steroid treatment. They were studied to determine the impact of the severity of overall injury (measured by MISS), neurologic injury (measured by GCS), and steroid administration on tot... | ['Adolescent', 'Brain Injuries', 'Child', 'Child, Preschool', 'Clinical Trials as Topic', 'Coma', 'Dexamethasone', 'Humans', 'Nitrogen', 'Nutritional Physiological Phenomena', 'Prospective Studies', 'Wounds and Injuries'] | 3,910,787 | [['M01.060.057'], ['C10.228.140.199', 'C10.900.300.087', 'C26.915.300.200'], ['M01.060.406'], ['M01.060.406.448'], ['E05.318.372.250.250', 'N05.715.360.330.250.250', 'N06.850.520.450.250.250'], ['C10.597.606.358.800.200', 'C23.888.592.604.359.800.200'], ['D04.210.500.745.432.769.344', 'D04.210.500.908.238'], ['B01.050.... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The effect of ankle muscle strength and flexibility on dolphin kick performance in competitive swimmers. | The velocity of a swimmer is determined by biomechanical and bioenergetics factors. However, little is known about the effect of ankle flexibility on dolphin kick performance. Next to this, scientific evidence is lacking concerning the influence of ankle muscle strength. Therefore, the aim of this study was to investig... | ['Adolescent', 'Ankle', 'Ankle Joint', 'Athletes', 'Athletic Performance', 'Biomechanical Phenomena', 'Child', 'Female', 'Humans', 'Knee', 'Knee Joint', 'Male', 'Motor Skills', 'Movement', 'Muscle Strength', 'Muscle, Skeletal', 'Range of Motion, Articular', 'Swimming', 'Young Adult'] | 24,984,154 | [['M01.060.057'], ['A01.378.610.050'], ['A02.835.583.378.062'], ['M01.072'], ['I03.450.642.845.054'], ['G01.154.090', 'G01.374.089'], ['M01.060.406'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A01.378.610.450'], ['A02.835.583.475'], ['F02.808.260'], ['G07.568', 'G11.427.410'], ['E01.370.600.425', 'G11.427.560'... | ['Named Groups [M]', 'Anatomy [A]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Resection of apical lung tumors in high-risk patients using partial sternotomy. | Surgical management of patients with compromised lung function remains a challenge. We describe a technique that uses a partial sternotomy to manage high-risk patients with clinical stage 1 apical lung tumors. In our experience with four patients we found this method to be effective, quick, safe, and with good short te... | ['Aged', 'Aged, 80 and over', 'Female', 'Follow-Up Studies', 'Humans', 'Lung Neoplasms', 'Male', 'Neoplasm Staging', 'Pneumonectomy', 'Respiratory Function Tests', 'Risk Assessment', 'Sternum', 'Survival Analysis', 'Treatment Outcome'] | 18,222,303 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['E01.789.625'], ['E04.620', 'E04.928.600.600'], ['E01.370.386.700'], ['E05.31... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Insight in the role of bovine serum albumin for promoting the in situ surface growth of polyhydroxybutyrate (PHB) on patterned surfaces via enzymatic surface-initiated polymerization. | Polyhydroxyalkanoates (PHAs) are a family of aliphatic polyesters produced by a variety of microorganisms as a reserve of carbon and energy. Enzymes involved in the synthesis of PHAs can be utilized to produce polymers in vitro, both in bulk and on solid surfaces. Here, site-specific attachment of the key catalytic enz... | ['Acyltransferases', 'Animals', 'Cattle', 'Coated Materials, Biocompatible', 'Cupriavidus necator', 'Enzymes', 'Gold', 'Humans', 'Hydroxybutyrates', 'Nanotechnology', 'Polyesters', 'Serum Albumin, Bovine'] | 17,629,682 | [['D08.811.913.050'], ['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['D25.130.420', 'J01.637.051.130.420'], ['B03.440.400.425.251.200.200', 'B03.660.075.090.688.200.200'], ['D08.811'], ['D01.268.556.322', 'D01.268.956.186', 'D01.552.544.322'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.241.081.114.9... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Tissue microarray analysis of cyclin-dependent kinase inhibitors p21 and p16 in Fuchs dystrophy. | PURPOSE: To investigate the novel application of tissue microarray (TMA) technology to corneal disease and to report altered protein expression of senescence-associated cyclin-dependent kinase inhibitors p21 and p16 in Fuchs endothelial corneal dystrophy (FECD).METHODS: A TMA including 208 cores was generated from para... | ['Aged', 'Cyclin-Dependent Kinase Inhibitor p16', 'Cyclin-Dependent Kinase Inhibitor p21', 'Female', "Fuchs' Endothelial Dystrophy", 'Humans', 'Immunohistochemistry', 'Male', 'Middle Aged', 'Tissue Array Analysis'] | 23,132,454 | [['M01.060.116.100'], ['D12.644.360.225.200', 'D12.776.167.187.200', 'D12.776.476.225.200', 'D12.776.624.776.355.200'], ['D12.644.360.225.500', 'D12.776.157.687.250', 'D12.776.167.187.500', 'D12.776.476.225.500', 'D12.776.624.776.355.500', 'D12.776.660.720.250'], ['C11.204.236.438', 'C11.270.162.438', 'C16.320.290.162.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Direct chemiluminescence immunoassay for estradiol in serum. | In this simple, reliable, fast solid-phase chemiluminescence immunoassay for directly measuring (i.e., without prior extraction) estradiol-17 beta in serum, a monoclonal antibody is used that binds estradiol with high affinity (Ka = 10(10) L/mol), and does not bind other steroids tested, the highest cross reactivity ob... | ['Antibodies, Anti-Idiotypic', 'Antibodies, Monoclonal', 'Antibody Specificity', 'Estradiol', 'Female', 'Humans', 'Immunoassay', 'Luminescent Measurements', 'Ovulation Induction', 'Radioimmunoassay'] | 3,489,572 | [['D12.776.124.486.485.114.071', 'D12.776.124.790.651.114.071', 'D12.776.377.715.548.114.071'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['G12.100'], ['D04.210.500.365.415.248', 'D06.472.334.851.437.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.478.5... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Isolation and characterization of Borrelia hermsii associated with two foci of tick-borne relapsing fever in California. | Relapsing fever, caused by the spirochete Borrelia hermsii and transmitted by the soft tick Ornithodoros hermsi, is endemic in many rural mountainous areas of California. Between 1996 and 1998, 12 cases of relapsing fever associated with two exposure sites in northern California were investigated. Follow-up at exposure... | ['Adult', 'Animals', 'Borrelia', 'California', 'Child', 'Child, Preschool', 'Female', 'Geography', 'Humans', 'Male', 'Middle Aged', 'Ornithodoros', 'Relapsing Fever', 'Rural Population'] | 15,004,063 | [['M01.060.116'], ['B01.050'], ['B03.440.425.410.711.193', 'B03.851.595.193'], ['Z01.107.567.875.580.200', 'Z01.107.567.875.760.200'], ['M01.060.406'], ['M01.060.406.448'], ['H01.277.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['B01.050.500.131.166.132.832.100.700'], ['C01.150.252.400.7... | ['Named Groups [M]', 'Organisms [B]', 'Geographicals [Z]', 'Disciplines and Occupations [H]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
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