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Essential role(s) of the intrarenal renin-angiotensin system in transforming growth factor-beta1 gene expression and induction of hypertrophy of rat kidney proximal tubular cells in high glucose. | These studies investigated the question of whether the intrarenal renin-angiotensin system (RAS) is essential for transforming growth factor-beta1 (TGF-beta1) gene expression and induction of hypertrophy of renal proximal tubular cells in high glucose in vitro. Antisense and sense angiotensinogen (ANG) cDNAs were stabl... | ['Angiotensinogen', 'Animals', 'Cell Line', 'Collagen Type IV', 'Dose-Response Relationship, Drug', 'Gene Expression', 'Glucose', 'Hypertrophy', 'Kidney', 'Kidney Tubules, Proximal', 'RNA, Messenger', 'Rats', 'Renin-Angiotensin System', 'Transfection', 'Transforming Growth Factor beta', 'Transforming Growth Factor beta... | 11,805,157 | [['D12.644.456.073.070', 'D12.644.861.020', 'D12.776.811.070', 'D12.776.872.020'], ['B01.050'], ['A11.251.210'], ['D12.776.860.300.250.400.100'], ['G07.690.773.875', 'G07.690.936.500'], ['G05.297'], ['D09.947.875.359.448'], ['C23.300.775'], ['A05.810.453'], ['A05.810.453.736.560.570'], ['D13.444.735.544'], ['B01.050.15... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Drug Reaction with Eosinophilia and Systemic Symptoms: Retrospective Analysis of 104 Cases over One Decade. | BACKGROUND: Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe, life-threatening disorder caused by drugs. In the present study, we tried to explore the types of DRESS-inducing drugs, incubation period, features of skin rashes, accompanying visceral damage, and effectiveness of glucocorticoid the... | ['Adolescent', 'Adult', 'Aged', 'Anti-Bacterial Agents', 'Dermatitis', 'Drug Hypersensitivity Syndrome', 'Eosinophilia', 'Exanthema', 'Female', 'Glucocorticoids', 'Humans', 'Immunosuppressive Agents', 'Liver', 'Male', 'Middle Aged', 'Retrospective Studies', 'Young Adult'] | 28,397,724 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.122.085'], ['C17.800.174'], ['C17.800.174.600.262', 'C20.543.206.380.262', 'C25.100.468.380.262'], ['C15.378.553.231'], ['C17.800.257'], ['D06.472.040.543', 'D27.505.696.399.472.488'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.47... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The impact of preexisting myocardial remodeling on ventricular function early after tetralogy of Fallot repair. | BACKGROUND: Twenty-three patients (median age 23 months) who underwent Fallot's tetralogy repair were investigated prospectively to detect a possible association between histopathologic myocardial remodeling and echocardiographic findings of systolic or diastolic ventricular dysfunction.METHODS: Intraoperatively resect... | ['Adolescent', 'Biopsy', 'Child', 'Child, Preschool', 'Collagen', 'Echocardiography, Doppler', 'Electrocardiography', 'Endothelium, Vascular', 'Female', 'Humans', 'Infant', 'Logistic Models', 'Male', 'Myocytes, Cardiac', 'Prospective Studies', 'Reproducibility of Results', 'Statistics, Nonparametric', 'Tetralogy of Fal... | 20,650,609 | [['M01.060.057'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['M01.060.406'], ['M01.060.406.448'], ['D05.750.078.280', 'D12.776.860.300.250'], ['E01.370.350.130.750.220', 'E01.370.350.850.220.220', 'E01.370.350.850.850.2... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Health Care [N]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Distribution of oral tumors in Nigerian children based on biopsy materials examined over an 11-year period. | A survey of biopsied lesions of patients aged 0-16 yr who presented with oral swellings at the Lagos University Teaching Hospital over a period of 11 yr was conducted to determine the pattern of presentation of these lesions in 203 Nigerian children, 123 boys and 80 girls. 21% of the lesions were fibro-osseous lesions.... | ['Adolescent', 'Age Factors', 'Child', 'Child, Preschool', 'Female', 'Humans', 'Jaw Neoplasms', 'Male', 'Mouth Neoplasms', 'Nigeria', 'Odontogenic Tumors', 'Retrospective Studies', 'Sex Factors'] | 2,387,136 | [['M01.060.057'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.149.721.450', 'C05.116.231.754.450', 'C05.500.499', 'C07.320.515'], ['C04.588.443.591', 'C07.465.530'], ['Z01.058.290.190.565'], ['C04.557.695'], ['E05.318.372.500.5... | ['Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Molybdenum cofactor biosynthesis in Escherichia coli. Requirement of the chlB gene product for the formation of molybdopterin guanine dinucleotide. | The chlorate-resistant mutants of Escherichia coli are affected in the biosynthesis of the molybdenum cofactor and show pleiotropic loss of the activities of those enzymes which require the cofactor. The molybdenum cofactor in all molybdoenzymes other than nitrogenase is a complex of the metal with a unique pterin term... | ['Chromatography, High Pressure Liquid', 'Coenzymes', 'Escherichia coli', 'Fluorescence Polarization', 'Guanine Nucleotides', 'Guanosine Monophosphate', 'Metalloproteins', 'Mutation', 'Pteridines', 'Pterins', 'Pyrophosphatases'] | 1,648,082 | [['E05.196.181.400.300'], ['D08.211'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['E05.196.712.516.600.390'], ['D03.633.100.759.646.454', 'D13.695.667.454', 'D13.695.827.426'], ['D03.633.100.759.646.454.400', 'D13.695.667.454.400', 'D13.695.827.426.400'], ['D12.776.556'], ['G05.365.590'], ['D03.633.100.73... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of dietary fat sources on the intramuscular and subcutaneous adipose tissue fatty acid composition, and consumer acceptability of lamb. | BACKGROUND: Lamb diets can alter the fatty acid (FA) profile of muscle and adipose tissue, which may affect the sensory quality and consumer acceptability of the meat. In this study, lambs received one of four pre-slaughter diets: a barley / maize / soya-based concentrate (C), supplemented with a saturated fat source (... | ['Adolescent', 'Adult', 'Aged', 'Animal Feed', 'Animals', 'Consumer Behavior', 'Cooking', 'Diet', 'Dietary Fats', 'Dietary Supplements', 'Fatty Acids', 'Female', 'Humans', 'Linoleic Acids, Conjugated', 'Linseed Oil', 'Male', 'Middle Aged', 'Red Meat', 'Sheep', 'Subcutaneous Fat', 'Taste', 'Young Adult'] | 31,901,142 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['G07.203.300.300.100', 'J02.500.300.100'], ['B01.050'], ['F01.145.236'], ['J01.576.423.200.200'], ['G07.203.650.240'], ['D10.212.302', 'G07.203.300.375', 'J02.500.375'], ['G07.203.300.456', 'J02.500.456'], ['D10.251'], ['B01.050.150.900.649.313.988.400.112.400.40... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 |
Metformin and Myocardial Injury in Patients With Diabetes and ST-Segment Elevation Myocardial Infarction: A Propensity Score Matched Analysis. | BACKGROUND: Although animal studies have documented metformin's cardioprotective effects, the impact in humans remains elusive. The study objective was to explore the association between metformin and myocardial infarct size in patients with diabetes presenting with ST-segment elevation myocardial infarction.METHODS AN... | ['Academic Medical Centers', 'Biomarkers', 'Chi-Square Distribution', 'Creatine Kinase, MB Form', 'Diabetes Mellitus, Type 1', 'Diabetes Mellitus, Type 2', 'Female', 'Humans', 'Hypoglycemic Agents', 'Male', 'Metformin', 'Myocardial Infarction', 'Myocardium', 'Percutaneous Coronary Intervention', 'Propensity Score', 'Re... | 26,494,519 | [['N02.278.020'], ['D23.101'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['D08.811.913.696.640.150.625'], ['C18.452.394.750.124', 'C19.246.267', 'C20.111.327'], ['C18.452.394.750.149', 'C19.246.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.422'... | ['Health Care [N]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Geographicals [Z]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
The relationship between adenosine 3',5'-monophosphate levels and systolic transmembrane calcium flux. | The effects of inotropic agents on systolic transmembrane Ca++ flux were studied in isolated perfused guinea pig hearts depolarized with 22 mM K+. After depolarization, inotropic agents were added to the perfusion medium in an attempt to resotre excitability and contractions to the heart. Electrophysiological studies h... | ['Animals', 'Biological Transport', 'Calcium', 'Cyclic AMP', 'Dose-Response Relationship, Drug', 'Guinea Pigs', 'Histamine', 'In Vitro Techniques', 'Isoproterenol', 'Myocardial Contraction', 'Myocardium', 'Ouabain', 'Papaverine', 'Potassium', 'Propranolol', 'Theophylline', 'Verapamil'] | 171,711 | [['B01.050'], ['G03.143'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D03.633.100.759.646.138.395', 'D13.695.462.200', 'D13.695.667.138.395', 'D13.695.827.068.395'], ['G07.690.773.875', 'G07.690.936.500'], ['B01.050.150.900.649.313.992.550'], ['D02.092.211.215.501', 'D02.092.471.440', 'D03.383.129.308.373... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Degree of polymerization of 5,6-dihydroxyindole-derived eumelanin from chemical degradation study. | Eumelanin is a brown-black pigment comprising 5,6-dihydroxyindole (DHI) and its 2-carboxy derivative (DHICA), but the detailed structure of eumelanin is unclear. Chemical degradation is a powerful tool for analyzing melanin. H2 O2 oxidation degradation of eumelanin affords pyrrole-2,3,5-tricarboxylic acid (PTCA) and py... | ['Indoles', 'Melanins'] | 24,750,564 | [['D03.633.100.473'], ['D12.125.072.050.875.379', 'D23.767.620']] | ['Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
CIZ1 promoted the growth and migration of gallbladder cancer cells. | Gallbladder cancer (GBC) is one of the most common and aggressive diseases among the gastrointestinal tract malignancies, and the molecular mechanism underlying this disease remains largely unknown. CIZ1 (Cip1 interacting zinc finger protein 1), a binding partner of p21(Cip1/Waf1), has been found to be involved in the ... | ['Cell Line, Tumor', 'Cell Movement', 'Cell Proliferation', 'Cell Transformation, Neoplastic', 'Gallbladder Neoplasms', 'Gene Expression Regulation, Neoplastic', 'Humans', 'Nuclear Proteins', 'Signal Transduction', 'beta Catenin'] | 25,427,641 | [['A11.251.210.190', 'A11.251.860.180'], ['G04.198', 'G07.568.500.180'], ['G04.161.750', 'G07.345.249.410.750'], ['C04.697.098.500', 'C23.550.727.098.500'], ['C04.588.274.120.401', 'C06.130.320.401', 'C06.130.564.401', 'C06.301.120.401'], ['G05.308.370'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.660']... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Incisional hernias with particular topography--alloplastic procedures]. | UNLABELLED: The aim of the study was to analyse the particular features and treatment difficulties of paramedian incisional hernias.MATERIAL AND METHOD: A retrospective study was performed on a series of 64 patients operated for incisional hernia with particular topography: right subcostal, right iliac and suprapubic a... | ['Digestive System Surgical Procedures', 'Hernia, Ventral', 'Humans', 'Polypropylenes', 'Retrospective Studies', 'Surgical Mesh', 'Surgical Procedures, Operative', 'Treatment Outcome'] | 20,209,773 | [['E04.210'], ['C23.300.707.374.937'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.455.326.271.665.590', 'D05.750.716.550', 'D25.720.716.550', 'J01.637.051.720.716.550'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.520.450.500.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Optical Properties of Secondary Organic Aerosol from cis-3-Hexenol and cis-3-Hexenyl Acetate: Effect of Chemical Composition, Humidity, and Phase. | Atmospheric aerosols play an important role in Earth's radiative balance directly, by scattering and absorbing radiation, and indirectly, by acting as cloud condensation nuclei (CCN). Atmospheric aerosol is dominated by secondary organic aerosol (SOA) formed by the oxidation of biogenic volatile organic compounds (BVOC... | ['Aerosols', 'Humidity', 'Oxidation-Reduction', 'Particle Size', 'Volatile Organic Compounds'] | 27,074,496 | [['D20.280.055', 'D26.255.165.055'], ['G16.500.275.063.725.310', 'G16.500.750.775.310', 'N06.230.150.372', 'N06.230.300.100.725.310'], ['G02.700', 'G03.295.531'], ['G02.712'], ['D02.974']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Using the health belief model to explain clinic appointment-keeping for the management of a chronic disease condition. | Broken appointments have untoward repercussions for patients' health and well-being. Although the literature on missed appointments has been largely atheoretical, several studies have tested the Health Belief Model (HBM) in this context. Those studies have found HBM dimensions are not predictive of keeping appointments... | ['Adult', 'Appointments and Schedules', 'Attitude to Health', 'Chronic Disease', 'Educational Status', 'Female', 'Humans', 'Lupus Erythematosus, Systemic', 'Male', 'Middle Aged', 'Models, Psychological', 'Motivation', 'Patient Compliance', 'Psychometrics', 'Regression Analysis', 'Reproducibility of Results', 'Surveys a... | 9,615,295 | [['M01.060.116'], ['N04.452.095'], ['F01.100.150', 'N05.300.150'], ['C23.550.291.500'], ['N01.824.196'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C17.300.480', 'C20.111.590'], ['M01.060.116.630'], ['E05.599.695'], ['F01.658', 'F01.752.543.500.750'], ['F01.100.150.750.500.600', 'F01.145.488.887.500.600', 'N05.... | ['Named Groups [M]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
DSM-III-R personality disorders in patients with eating disorders. | The authors conducted a systematic examination of DSM-III-R personality disorders among 35 patients with eating disorders. Fifty-seven percent of the patients met the criteria for at least one axis II diagnosis; borderline, self-defeating, and avoidant were the most frequently assigned personality disorders. Forty perc... | ['Adult', 'Anorexia Nervosa', 'Borderline Personality Disorder', 'Bulimia', 'Female', 'Hospitalization', 'Humans', 'Personality Disorders', 'Psychiatric Status Rating Scales'] | 2,589,552 | [['M01.060.116'], ['F03.400.125'], ['F03.675.100'], ['C23.888.821.645.500'], ['E02.760.400', 'N02.421.585.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F03.675'], ['F04.711.513.653']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Short-term clinical effects of adjunctive antimicrobial photodynamic therapy in periodontal treatment: a randomized clinical trial. | OBJECTIVE: The aim of this study was to assess the effect of adjunctive antimicrobial photodynamic therapy (aPDT) in chronic periodontitis.MATERIAL AND METHODS: Twenty patients with untreated chronic periodontitis were included. All teeth received periodontal treatment comprising scaling and root planing. Using a split... | ['Adult', 'Chronic Periodontitis', 'Combined Modality Therapy', 'Dental Deposits', 'Dental Scaling', 'Female', 'Gingiva', 'Humans', 'Low-Level Light Therapy', 'Male', 'Middle Aged', 'Periodontal Attachment Loss', 'Periodontal Index', 'Phenothiazines', 'Photochemotherapy', 'Photosensitizing Agents', 'Single-Blind Method... | 18,713,259 | [['M01.060.116'], ['C07.465.714.533.324'], ['E02.186'], ['C07.793.208'], ['E06.721.189.350', 'E06.761.227.350'], ['A14.549.167.646.480'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.594.540', 'E02.774.500'], ['M01.060.116.630'], ['C07.465.714.354.750'], ['E05.318.308.980.438.300.725', 'E06.208.720', 'E06.721... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Profiling multiple provider prescribing of opioids, benzodiazepines, stimulants, and anorectics. | BACKGROUND: The main objective of this study was to determine the prevalence of multiple providers for different controlled substances using the largest electronic prescription monitoring program (PMP) in the United States. A secondary objective was to explore patient and medication variables associated with prescripti... | ['Analgesics, Opioid', 'Appetite Depressants', 'Benzodiazepines', 'Central Nervous System Agents', 'Drug Prescriptions', 'Female', 'Humans', 'Inappropriate Prescribing', 'Male', 'Physician-Patient Relations', 'Polypharmacy', "Practice Patterns, Physicians'"] | 20,566,252 | [['D27.505.696.277.600.500', 'D27.505.696.663.850.014.760.500', 'D27.505.954.427.040.550.500', 'D27.505.954.427.210.600.500'], ['D27.505.954.203.155'], ['D03.633.100.079.080'], ['D27.505.954.427'], ['E02.319.307', 'N02.421.668.778.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.490', 'N02.421.450.500.... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Time course and duration of changes in Kv7.2 and Kv11.1 mRNA expression in the hippocampus and piriform cortex following electroconvulsive stimulations. | BACKGROUND: A minimum of six electroconvulsive therapy (ECT) treatments has to be delivered to achieve sustained improvement in major depression. However, the mechanisms of the therapeutic actions of ECT are still debated.OBJECTIVE: We aimed to study the time course and duration of increased Kv7.2 and Kv11.1 mRNA expre... | ['Animals', 'ERG1 Potassium Channel', 'Electroshock', 'Ether-A-Go-Go Potassium Channels', 'Hippocampus', 'KCNQ2 Potassium Channel', 'Male', 'RNA, Messenger', 'Rats', 'Rats, Sprague-Dawley'] | 22,037,135 | [['B01.050'], ['D12.776.157.530.400.600.900.249.500', 'D12.776.543.550.450.750.900.249.500', 'D12.776.543.585.400.750.900.249.500'], ['E05.723.402.403', 'F04.669.224'], ['D12.776.157.530.400.600.900.249', 'D12.776.543.550.450.750.900.249', 'D12.776.543.585.400.750.900.249'], ['A08.186.211.180.405', 'A08.186.211.200.885... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
PKR is not obligatory for high-fat diet-induced obesity and its associated metabolic and inflammatory complications. | Protein kinase R (PKR) has previously been suggested to mediate many of the deleterious consequences of a high-fat diet (HFD). However, previous studies have observed substantial phenotypic variability when examining the metabolic consequences of PKR deletion. Accordingly, herein, we have re-examined the role of PKR in... | ['Adipose Tissue, White', 'Animals', 'Body Composition', 'CD11 Antigens', 'CD3 Complex', 'Calcium-Binding Proteins', 'Chemokine CCL2', 'Diet, High-Fat', 'Disease Models, Animal', 'Fatty Liver', 'Flow Cytometry', 'Gene Expression Profiling', 'Glucose Tolerance Test', 'Immunoblotting', 'Inflammation', 'Insulin', 'Integri... | 26,838,266 | [['A10.165.114.830'], ['B01.050'], ['G02.111.130', 'G03.180', 'G07.100.049'], ['D12.776.395.550.200.074', 'D12.776.543.550.200.093', 'D23.050.301.350.074'], ['D23.050.301.264.894.095', 'D23.101.100.894.095'], ['D12.776.157.125'], ['D12.644.276.374.200.110.990.600', 'D12.776.467.374.200.110.990.600', 'D23.125.300.110.99... | ['Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Early home-based recognition of anaemia via general danger signs, in young children, in a malaria endemic community in north-east Tanzania. | BACKGROUND: Ethnographic studies from East Africa suggest that cerebral malaria and anaemia are not classified in local knowledge as malaria complications, but as illnesses in their own right. Cerebral malaria 'degedege' has been most researched, in spite of anaemia being a much more frequent complication in infants, a... | ['Algorithms', 'Anemia', 'Health Education', 'Humans', 'Infant', 'Infant, Newborn', 'Longitudinal Studies', 'Malaria', 'Mothers', 'Prospective Studies', 'Tanzania'] | 17,116,250 | [['G17.035', 'L01.224.050'], ['C15.378.071'], ['I02.233.332', 'N02.421.726.407'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['E05.318.372.500.750.500', 'N05.715.360.330.500.750.500', 'N06.850.520.450.500.750.500'], ['C01.610.752.530', 'C01.920.875'], ['F01.829.263.500.320.20... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
Human disk cells from degenerated disks and mesenchymal stem cells in co-culture result in increased matrix production. | Transplantation of mesenchymal stem cells (MSCs) has been suggested for disk degeneration, which is characterized by dysfunctional cells and low proteoglycan production. The aim of this study was to examine the effects of a 3D co-culture system using human disk cells (DCs) and MSCs on collagen and proteoglycan producti... | ['Bone Marrow Cells', 'Cell Communication', 'Coculture Techniques', 'Collagen Type II', 'Culture Media, Conditioned', 'Extracellular Matrix', 'Glycosaminoglycans', 'Humans', 'Hydroxyproline', 'Intervertebral Disc', 'Intervertebral Disc Degeneration', 'Mesenchymal Stem Cells', 'Proteoglycans'] | 19,494,482 | [['A11.148', 'A15.378.316'], ['G04.085'], ['E05.481.500.374'], ['D05.750.078.280.300.200', 'D12.776.860.300.250.300.200'], ['D27.720.470.305.250', 'E07.206.250'], ['A11.284.295.310'], ['D09.698.373'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.125.072.401.623.478'], ['A02.165.308.410', 'A02.835.232.834.432'... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
No impact of lentiviral transduction on hematopoietic stem/progenitor cell telomere length or gene expression in the rhesus macaque model. | The occurrence of clonal perturbations and leukemia in patients transplanted with gamma-retroviral (RV) vector-transduced autologous hematopoietic stem and progenitor cells (HSPCs) has stimulated extensive investigation, demonstrating that proviral insertions may perturb adjacent proto-oncogene expression. Although enh... | ['Animals', 'Antigens, CD34', 'Gene Expression', 'Genetic Vectors', 'Green Fluorescent Proteins', 'Hematopoietic Stem Cell Transplantation', 'Hematopoietic Stem Cells', 'Lentivirus', 'Leukocytes, Mononuclear', 'Macaca mulatta', 'Telomere', 'Transcriptome', 'Transduction, Genetic', 'Transgenes'] | 23,863,881 | [['B01.050'], ['D23.050.301.264.035.134', 'D23.101.100.110.134'], ['G05.297'], ['G05.360.337'], ['D12.776.532.265'], ['E02.095.147.500.500.500', 'E04.936.225.687.500'], ['A11.148.378', 'A11.872.378', 'A15.378.316.378'], ['B04.820.650.589'], ['A11.118.637.555', 'A15.145.229.637.555', 'A15.382.490.555'], ['B01.050.150.90... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Agglutination of isolated platelet membranes. | Platelet membrane glycoproteins play a central role in platelet aggregation and thus in primary hemostasis. To investigate mechanisms of platelet-platelet interaction in the absence of cellular activation events, we studied immunological and functional aspects of isolated platelet membranes. Platelet membranes containe... | ['Agglutination', 'Antibodies, Monoclonal', 'Blood Platelets', 'Cations, Divalent', 'Cell Membrane', 'Electrophoresis, Polyacrylamide Gel', 'Flow Cytometry', 'Immunoblotting', 'Membrane Proteins', 'Microscopy, Electron, Scanning', 'Platelet Glycoprotein GPIIb-IIIa Complex'] | 8,963,718 | [['G02.111.026', 'G12.122.100'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['A11.118.188', 'A15.145.229.188'], ['D01.248.497.300.333'], ['A11.284.149'], ['E05.196.401.402', 'E05.301.300.319'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.60... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Characterization of a possible nosocomial aspergillosis outbreak. | OBJECTIVE: To study the epidemiologic aspects of a suspected outbreak of nosocomial invasive aspergillosis.METHODS: Sixteen Aspergillus fumigatus strains were isolated from bronchoalveolar washings or sputa of 10 patients during a 9-month period. Furthermore, two environmental samples, isolated in a microbiological scr... | ['Aspergillosis', 'Aspergillus fumigatus', 'Bronchoalveolar Lavage Fluid', 'Cross Infection', 'Disease Outbreaks', 'Electrophoresis, Agar Gel', 'Genetic Variation', 'Genotype', 'Humans', 'Lung Diseases, Fungal', 'Random Amplified Polymorphic DNA Technique', 'Spain', 'Sputum'] | 11,168,048 | [['C01.150.703.080'], ['B01.300.381.081.295'], ['E05.927.100.500'], ['C01.248', 'C23.550.291.875.500'], ['N06.850.290'], ['E05.196.401.153', 'E05.301.300.100'], ['G05.365'], ['G05.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C01.150.703.534', 'C01.748.435', 'C08.381.472', 'C08.730.435'], ['E05.393.620.500.... | ['Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Adeno-associated virus interactions with B23/Nucleophosmin: identification of sub-nucleolar virion regions. | Adeno-associated virus (AAV) is a human parvovirus that normally requires a helper virus such as adenovirus (Ad) for replication. The four replication proteins (Rep78, 68, 52 and 40) encoded by AAV are pleiotropic effectors of virus integration, replication, transcription and virion assembly. Using Rep68 column chromat... | ['Cell Nucleolus', 'DNA-Binding Proteins', 'Dependovirus', 'Fluorescent Antibody Technique', 'HeLa Cells', 'Humans', 'Immunoprecipitation', 'Nuclear Proteins', 'Protein Binding', 'Viral Proteins', 'Virion', 'Virus Assembly'] | 16,959,286 | [['A11.284.430.106.279.345.175'], ['D12.776.260'], ['B04.280.580.650.170'], ['E01.370.225.500.607.512.240', 'E01.370.225.750.551.512.240', 'E05.200.500.607.512.240', 'E05.200.750.551.512.240', 'E05.478.583.375'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'], ['B01.050.150.900.649.313.988.400.112.400.40... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Variability and tracking of physical activity over 2 yr in young children. | The purpose of this study was to examine tracking of physical activity at home and recess in young children. Three hundred fifty-one Mexican-American and Anglo-American children entered the study (mean age = 4.4 yr), and 83% completed 2 yr of measurement. Physical activity was directly observed on 10 d over 2 yr. Measu... | ['Child Behavior', 'Child, Preschool', 'Data Interpretation, Statistical', 'Exercise', 'Female', 'Humans', 'Male', 'Play and Playthings'] | 7,564,971 | [['F01.145.179'], ['M01.060.406.448'], ['E05.245.380', 'E05.318.740.300', 'L01.313.500.750.190.380', 'N05.715.360.750.300', 'N06.850.520.830.300'], ['G11.427.410.698.277', 'I03.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I03.450.642.693']] | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 0 |
Dielectric relaxation study of glycine and valine in water mixture using picosecond time domain reflectometry. | The complex permittivity of glycine and valine in water mixture for various temperatures and concentrations have been measured as a function of frequency between 10 MHz and 10 GHz using (TDR) time domain reflectometry technique. Dielectric parameters ie. static dielectric constant and relaxation time were obtained from... | ['Electrochemistry', 'Glycine', 'Thermodynamics', 'Time Factors', 'Valine', 'Water'] | 9,491,649 | [['H01.181.529.307'], ['D12.125.481'], ['G01.906'], ['G01.910.857'], ['D12.125.070.950', 'D12.125.142.930'], ['D01.045.250.875', 'D01.248.497.158.459.650', 'D01.650.550.925']] | ['Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Benefits of Fenofibrate in prenatal valproic acid-induced autism spectrum disorder related phenotype in rats. | Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder with two major behavioral symptoms i.e. repetitive behavior and social-communication impairment. The unknown etiology of ASD is responsible for the difficulty in identifying the possible therapeutic modulators for ASD. Valproic acid (VPA) is an anticonvuls... | ['Animals', 'Anticonvulsants', 'Anxiety', 'Autism Spectrum Disorder', 'Autistic Disorder', 'Behavior, Animal', 'Brain', 'Disease Models, Animal', 'Exploratory Behavior', 'Female', 'Fenofibrate', 'Inflammation', 'Male', 'Oxidative Stress', 'PPAR alpha', 'Pregnancy', 'Prenatal Exposure Delayed Effects', 'Rats', 'Rats, Wi... | 30,769,127 | [['B01.050'], ['D27.505.954.427.080'], ['F01.470.132'], ['F03.625.164.113'], ['F03.625.164.113.500'], ['F01.145.113'], ['A08.186.211'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['F01.145.387', 'F01.658.370'], ['D02.241.081.114.968.500.625', 'D02.355.726.305.625', 'D02.455.426.559.389.134.750', 'D02.455.426.559.38... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Ifosfamide neurotoxicity. A challenge for nurses, a potential nightmare for patients. | The alkylator-like agent ifosfamide, which has been found to be useful in the treatment of a number of solid tumors, can have severe central nervous system (CNS) side effects in addition to causing myelosuppression, nephrotoxicity, nausea and vomiting, pulmonary edema, and interstitial pneumonitis. This article, includ... | ['Brain Diseases', 'Carcinoma, Small Cell', 'Central Nervous System', 'Female', 'Humans', 'Ifosfamide', 'Lung Neoplasms', 'Middle Aged', 'Neoplasms', 'Substance-Related Disorders'] | 8,384,523 | [['C10.228.140'], ['C04.557.470.200.380'], ['A08.186'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.455.526.728.650.730.243.250', 'D02.705.672.500.243.250', 'D03.383.533.500'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['M01.060.116.630'], ['C04'], ['C25.775', 'F03.900']] | ['Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Named Groups [M]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Abnormal expression of TIMP-2, SOD, vimentin and PAI proteins in cloned bovine placentae. | Cloned mammals suffer from high rates of placental abnormality and foetal loss during pregnancy. We previously used 2-D gel electrophoresis and mass spectrometry for global proteomic analysis of cloned and normal bovine placentae to identify differential protein expression patterns. Here, we used Western blot analysis ... | ['Animals', 'Animals, Genetically Modified', 'Cattle', 'Cloning, Organism', 'Female', 'Matrix Metalloproteinase 2', 'Nuclear Transfer Techniques', 'Placenta', 'Plasminogen Activator Inhibitor 1', 'Pregnancy', 'Superoxide Dismutase', 'Tissue Inhibitor of Metalloproteinase-2', 'Vimentin'] | 18,992,129 | [['B01.050'], ['B01.050.050.136', 'B05.620.136'], ['B01.050.150.900.649.313.500.380.271'], ['E05.393.240', 'E05.820.180'], ['D08.811.277.656.300.480.205.352', 'D08.811.277.656.300.480.252.420', 'D08.811.277.656.300.480.525.700.150', 'D08.811.277.656.675.374.205.352', 'D08.811.277.656.675.374.252.420', 'D08.811.277.656.... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A randomized controlled trial of postcrisis suicide prevention. | OBJECTIVE: This study tested the hypothesis that professionals' maintenance of long-term contact with persons who are at risk of suicide can exert a suicide-prevention influence. This influence was hypothesized to result from the development of a feeling of connectedness and to be most pertinent to high-risk individual... | ['Adult', 'Aftercare', 'California', 'Depressive Disorder', 'Female', 'Humans', 'Male', 'Postal Service', 'Statistics, Nonparametric', 'Suicide', 'Survival Analysis', 'Survival Rate', 'Treatment Refusal'] | 11,376,235 | [['M01.060.116'], ['E02.760.169.063', 'N02.421.585.169.063', 'N04.590.233.727.210.063'], ['Z01.107.567.875.580.200', 'Z01.107.567.875.760.200'], ['F03.600.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I01.451.617'], ['E05.318.740.995', 'N05.715.360.750.760', 'N06.850.520.830.995'], ['F01.145.126.980.875', '... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Alignment of electron tomographic series by correlation without the use of gold particles. | Electron tomography requires that a tilt series of micrographs be aligned and that the orientation of the tilt axis be known. This has been done conveniently with gold markers applied to the surface of a specimen to provide easily accessible information on the orientation of each tilt projection. Where gold markers are... | ['Animals', 'Gold', 'Image Enhancement', 'Microscopy, Electron', 'Tendons', 'Tomography', 'Turkeys'] | 8,785,010 | [['B01.050'], ['D01.268.556.322', 'D01.268.956.186', 'D01.552.544.322'], ['E01.370.350.600.350', 'L01.224.308.380'], ['E01.370.350.515.402', 'E05.595.402'], ['A02.880'], ['E01.370.350.825'], ['B01.050.150.900.248.350.800', 'B01.050.150.900.248.690.800']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Theoretical and experimental modeling of interstitial laser hyperthermia with surface cooling device using Nd3+ | To improve methods of laser hyperthermia for the treatment of bulk malignant neoplasms, an urgent task is the development of techniques and devices that automatically control heating at a given tissue depth and ensure its uniformity. The article proposes the concept of a system for performing hyperthermia with real-tim... | ['Cold Temperature', 'Hyperthermia, Induced', 'Laser Therapy', 'Luminescence', 'Models, Theoretical', 'Monte Carlo Method', 'Nanoparticles', 'Neodymium', 'Neoplasms', 'Optical Devices', 'Phantoms, Imaging'] | 30,762,195 | [['G01.906.595.272', 'G16.500.275.063.725.710.300', 'G16.500.750.775.710.300', 'N06.230.300.100.725.154', 'N06.230.300.100.725.710.300'], ['E02.565'], ['E02.594', 'E04.014.520'], ['G01.358.500.505.650.665', 'G01.590.540.665', 'G01.750.250.650.665', 'G01.750.770.578.665'], ['E05.599'], ['E05.318.740.525', 'L01.906.394.4... | ['Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 |
[Hemoglobins, XXXVI: The primary structure of a dimeric insect hemoglobin (Erythrocruorin), component IX from Chironomus thummi thummi. Studies on the quarternary structure of the dimeric CTT-hemoglobins (author's transl)]. | The primary structure of a dimeric insect hemoglobin (erythrocruorin), component CTT IX (Chironomus thummi thummi) was established by automatic sequence analysis. The alignment of the peptides was facilitated by producing only a few large fragments. The primary structure of CTT IX is compared with the human beta-chains... | ['Amino Acid Sequence', 'Chironomidae', 'Cyanogen Bromide', 'Diptera', 'Erythrocruorins', 'Hemoglobins', 'Macromolecular Substances', 'Peptide Fragments', 'Protein Conformation'] | 7,216,162 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050.500.131.617.720.500.500.750.712.500.750'], ['D01.139.300.050.100', 'D01.625.175'], ['B01.050.500.131.617.720.500.500.750'], ['D12.776.093.312', 'D12.776.422.316.762.260'], ['D12.776.124.400', 'D12.776.422.316.762'], ['D05'], ['D12.644.541'], ['G02.111.570.820.709']... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Clinical Assessment of Differential Diagnostic Methods in Infants with Cholestasis due to Biliary Atresia or Non-Biliary Atresia. | The different methods in differentiating biliary atresia (BA) from non-BA-related cholestasis were evaluated in order to provide a practical basis for a rapid, early and accurate differential diagnosis of the diseases. 396 infants with cholestatic jaundice were studied prospectively during the period of May 2007 to Jun... | ['Bile Acids and Salts', 'Biliary Atresia', 'Biomarkers', 'Cholangiography', 'Cholangiopancreatography, Magnetic Resonance', 'Cholestasis', 'Diagnosis, Differential', 'Feces', 'Female', 'Humans', 'Infant', 'Infant, Newborn', 'Jaundice, Neonatal', 'Liver', 'Male', 'Sensitivity and Specificity', 'Ultrasonography'] | 30,074,163 | [['D04.210.500.105'], ['C06.130.120.123', 'C06.198.125', 'C16.131.314.125'], ['D23.101'], ['E01.370.350.700.715.200', 'E01.370.372.200'], ['E01.370.350.825.500.100', 'E01.370.372.207'], ['C06.130.120.135'], ['E01.171'], ['A12.459'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
5-HT1A receptor-dependent modulation of emotional and neurogenic deficits elicited by prolonged consumption of alcohol. | Repeated episodes of binge-like alcohol consumption produce anxiety, depression and various deleterious effects including alterations in neurogenesis. While the involvement of the serotonin receptor 1 A (5-HT1A) in the regulation of anxiety-like behavior and neurogenesis is well documented, its contribution to alcohol ... | ['Alcohol Drinking', 'Animals', 'Anxiety', 'Depressive Disorder', 'Emotions', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Nervous System Diseases', 'Receptor, Serotonin, 5-HT1A'] | 29,391,482 | [['F01.145.317.269'], ['B01.050'], ['F01.470.132'], ['F03.600.300'], ['F01.470'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420'], ['C10'], ['D12.776.543.750.670.800.100.100', 'D12.776.543.750.695.800.100.100', 'D12.776.543.750.720.850.100.... | ['Psychiatry and Psychology [F]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Ventromedial hypothalamic lesions attenuate responses of sympathetic nerves to carotid arterial infusions of glucose and insulin. | The effects of intracarotid injections of glucose and insulin on the sympathetic firing of nerves to brown adipose tissue were measured in rats. The injection of glucose into the carotid artery of anesthetized rats increased the firing of nerve filaments from the sympathetic nerves which innervate brown adipose tissue.... | ['Adipose Tissue, Brown', 'Animals', 'Blood Glucose', 'Brain Mapping', 'Eating', 'Evoked Potentials', 'Female', 'Insulin', 'Rats', 'Receptors, Cell Surface', 'Sympathetic Nervous System', 'Ventromedial Hypothalamic Nucleus'] | 2,160,442 | [['A10.165.114.322'], ['B01.050'], ['D09.947.875.359.448.500'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['G07.203.650.283', 'G10.261.330'], ['G07.265.216.500', 'G11.561.200.500'], ['D06.472.699.587.200.500.625', 'D12.644.548.586.200.500.625'], ['B01.050.150.900.649.313.992.635.505.700... | ['Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A monoclonal antibody against very late activation antigen-4 inhibits eosinophil accumulation and late asthmatic response in a guinea pig model of asthma. | Preferential eosinophil accumulation is a characteristic of airway inflammation in asthma. Although little is known about its mechanism, recent in vitro observations suggest that the very late activation antigen-4 (VLA-4, CD49d/CD29) and vascular cell adhesion molecule-1 (VCAM-1) adhesion pathway may be involved in spe... | ['Animals', 'Antibodies, Monoclonal', 'Asthma', 'Cell Adhesion', 'Cell Movement', 'Cross Reactions', 'Disease Models, Animal', 'Endothelium, Vascular', 'Eosinophils', 'Flow Cytometry', 'Fluorescent Antibody Technique', 'Guinea Pigs', 'Immunoblotting', 'Integrin alpha4beta1', 'Integrins', 'Male', 'Precipitin Tests', 'Re... | 9,066,516 | [['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['G04.022'], ['G04.198', 'G07.568.500.180'], ['G12.122.281'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['A07.015.700.500', 'A10.272... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Noninvasive evaluation of corneal viscoelasticity based on displacement in response to acoustic radiation force. | Noninvasive assessment of corneal mechanical properties in vivo will help to the understanding of the pathogenesis and early diagnosis of ectatic corneal disorders. This study presented a noninvasive method that assesses the corneal biomechanical properties by exciting the cornea with acoustic radiation force and monit... | ['Animals', 'Cattle', 'Collagen', 'Cornea', 'Cross-Linking Reagents', 'Elasticity', 'Elasticity Imaging Techniques', 'Photosensitizing Agents', 'Ultraviolet Rays', 'Viscosity'] | 29,060,143 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['D05.750.078.280', 'D12.776.860.300.250'], ['A09.371.060.217'], ['D27.720.470.410.210'], ['G01.374.590'], ['E01.370.350.850.270'], ['D27.505.954.444.600', 'D27.505.954.600.710'], ['G01.358.500.505.650.891', 'G01.590.540.891', 'G01.750.250.650.891', 'G01.750.750.65... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Detection of antigens in the urine of patients with acute Plasmodium vivax malaria. | Plasmodium antigens were detected by dot-blot assay in the urine of 50 patients infected with Plasmodium vivax. Antigens also were detected in 12/15 patients who no longer had detectable parasitemia, 3 weeks after chemotherapy. Antigenuria was negative 6 weeks after treatment. By Western blotting, four predominant prot... | ['Adolescent', 'Adult', 'Animals', 'Antigens, Protozoan', 'Blotting, Western', 'Female', 'Humans', 'Immunoblotting', 'Malaria, Vivax', 'Male', 'Middle Aged', 'Plasmodium vivax'] | 8,454,019 | [['M01.060.057'], ['M01.060.116'], ['B01.050'], ['D23.050.293'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.478.566.320', 'E05.601.470.320'], ['C01.610.752.530.700', 'C01.920.875.700'], ['M01.060.116.630'], ... | ['Named Groups [M]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Biosynthesis of major plasma proteins in the primary culture of fat body cells from the silkworm, Bombyx mori. | Plasma proteins termed "SP1" and "30K proteins" are synthesized by the fat body cells of the silkworm, Bombyx mori, in a sex- and stage-specific manner during larval development. We successfully established a primary culture of the fat body cells in order to investigate the regulatory mechanisms of plasma protein gene ... | ['Animals', 'Blood Proteins', 'Bombyx', 'Cells, Cultured', 'Fat Body', 'Female', 'Immunohistochemistry', 'Insect Proteins', 'Larva', 'Male', 'Sex Characteristics'] | 10,470,503 | [['B01.050'], ['D12.776.124'], ['B01.050.500.131.617.720.500.500.937.650.100'], ['A11.251'], ['A13.365'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512', 'H01.158.201.344.512', 'H01.158.201.486.512', 'H01.181.122.573.512', 'H... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
The global burden of tuberculosis mortality in children: a mathematical modelling study. | BACKGROUND: Tuberculosis in children is increasingly recognised as an important component of the global tuberculosis burden, with an estimated 1 million cases in 2015. Although younger children are vulnerable to severe forms of tuberculosis disease, no age-disaggregated estimates of paediatric tuberculosis mortality ex... | ['Adolescent', 'Child', 'Child Mortality', 'Child, Preschool', 'Cost of Illness', 'Global Health', 'Humans', 'Infant', 'Infant, Newborn', 'Models, Theoretical', 'Tuberculosis'] | 28,807,188 | [['M01.060.057'], ['M01.060.406'], ['E05.318.308.985.550.287', 'N01.224.935.698.150', 'N06.850.505.400.975.550.287', 'N06.850.520.308.985.550.287'], ['M01.060.406.448'], ['N03.219.151.165', 'N05.715.360.300.800.438.375.182', 'N06.850.520.308.980.438.475.046'], ['H02.403.371', 'N01.400.337'], ['B01.050.150.900.649.313.9... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
[Topical immunomodulation. A milestone for the treatment of therapy-resistant noninfectious chronic external otitis?]. | BACKGROUND: Recurrent exacerbation of chronic external otitis represents a special challenge for the attending physician. The goal of our study was to evaluate the effectiveness of novel topical immunomodulators acting through an anti-inflammatory, nonsteroidal mechanism.PATIENTS AND METHODS: In a prospective study, in... | ['Administration, Topical', 'Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Child', 'Child, Preschool', 'Chronic Disease', 'Drug Resistance', 'Female', 'Humans', 'Immunologic Factors', 'Immunosuppressive Agents', 'Male', 'Middle Aged', 'Otitis Externa', 'Tacrolimus', 'Treatment Outcome'] | 17,876,560 | [['E02.319.267.120'], ['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['M01.060.406'], ['M01.060.406.448'], ['C23.550.291.500'], ['G07.690.773.984'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.477'], ['D27.505.696.477.656'], ['M01.060.116.630'], ['C09.218.705.496'], [... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A simple procedure for obtaining high-quality NMR spectra of semiquantitative value from small tissue specimens: cervical biopsies. | The handling of small tissue biopsy samples (< 100 microliters) for NMR investigations poses special problems. Optimal and stable positioning of the samples within the sensitive volume of the radiofrequency coil can be achieved by inserting the sample in a capillary. Methods for quantitation of the spectral information... | ['Biopsy', 'Cervix Uteri', 'Equipment Design', 'Female', 'Humans', 'Magnetic Resonance Spectroscopy', 'Specimen Handling', 'Uterine Cervical Diseases', 'Uterine Cervical Neoplasms'] | 1,461,119 | [['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['A05.360.319.679.256'], ['E05.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.196.867.519'], ['E01.370.225.998', 'E05.200.998'], ['C13.351.500.852.593'], ['C04.5... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
'Essentially it's just a lot of bedrooms': architectural design, prescribed personalisation and the construction of care homes for later life. | This article draws on ethnographic data from a UK Economic and Social Research Council (ESRC) funded study called 'Buildings in the Making'. The project aims to open up the black box of architectural work to explore what happens between the commissioning of architectural projects through to the construction of building... | ['Aged', 'Beds', 'Facility Design and Construction', 'Homes for the Aged', 'Humans', 'Patient-Centered Care', 'United Kingdom'] | 29,701,241 | [['M01.060.116.100'], ['E07.325.220'], ['J01.086.339', 'N02.278.200'], ['J03.775.462', 'N02.278.825.462'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N04.590.233.727.407'], ['Z01.542.363']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
[Synthesis and antibacterial activity of tricycic fluoroquinolones]. | Twelve new analogues of new tricyclic rufloxacin were prepared and their MIC were evaluated against thirteen kinds of bacteria. As a result of these studies: the polarity of C10-side chain was found to exert greater positive effect on G- than on G+ bacteria. | ['Anti-Infective Agents', 'Fluoroquinolones', 'Quinolones'] | 11,498,869 | [['D27.505.954.122'], ['D03.633.100.810.835.322'], ['D03.633.100.810.835']] | ['Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
PI3K-ã inhibition ameliorates acute lung injury through regulation of IêBá/NF-êB pathway and innate immune responses. | BACKGROUND: Acute lung injury (ALI) is a devastating disorder of the lung by various causes and its cardinal features are tissue inflammation, pulmonary edema, low lung compliance, and widespread capillary leakage. Among phosphoinositide 3-kinases (PI3Ks), PI3K-ã isoform has been shown to play an important role in a nu... | ['Acute Lung Injury', 'Animals', 'Cell Nucleus', 'Class Ib Phosphatidylinositol 3-Kinase', 'Cytokines', 'Dendritic Cells', 'Enzyme Activation', 'Female', 'I-kappa B Proteins', 'Immunity, Innate', 'Inflammation Mediators', 'Intercellular Adhesion Molecule-1', 'Lipopolysaccharides', 'Mice', 'Mice, Inbred C57BL', 'NF-Kapp... | 22,198,681 | [['C08.381.520.500'], ['B01.050'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['D08.811.913.696.620.500.100.100.200', 'D08.811.913.696.620.500.200.100.200', 'D12.776.476.162.200'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['A11.066.270', 'A11.436.270', 'A15.382.066.270', 'A15.382.670.260'], ['G02... | ['Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Interprofessional symptom management at the end of life]. | At the end of life patients often show distressful symptoms which significantly reduce their quality of life. The goal of all healthcare professionals should be to recognize the beginning of this end of life period in order to provide good symptom management. For this purpose, existing symptoms have to be recorded, sui... | ['Humans', 'Palliative Care', 'Quality of Life', 'Terminal Care'] | 29,691,593 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.760.666', 'N02.421.585.666'], ['I01.800', 'K01.752.400.750', 'N06.850.505.400.425.837'], ['E02.760.905', 'N02.421.585.905']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Primary care physicians' perspectives of the survivorship care for older breast cancer survivors: a pilot study. | PURPOSE: To evaluate primary care physicians' (PCPs) role in survivorship care of older breast cancer survivors, their experiences and opinions of survivorship care plans (SCPs), and suggestions for improving care coordination and facilitation of SCPs among older (? 65 years) breast cancer survivors.METHODS: A web-base... | ['Adult', 'Breast Neoplasms', 'Cancer Survivors', 'Female', 'Humans', 'Male', 'Physicians, Primary Care', 'Pilot Projects', 'Survivorship'] | 31,119,461 | [['M01.060.116'], ['C04.588.180', 'C17.800.090.500'], ['M01.860.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.526.485.810.800', 'N02.360.810.795'], ['E05.318.372.750', 'E05.337.737', 'N05.715.360.330.720', 'N06.850.520.450.720'], ['F01.058.144.500']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Examination of eye position after strabismus surgery in Kawasaki Medical School Hospital]. | PURPOSE: To examine the factors which affect changes in the position of the eyes following the strabismus surgery.METHODS: The postoperative position of 240 eyes with concomitant strabismus was examined. The factors which seemed to have an effect on the position of the eyes were enumerated, and a logistic regression an... | ['Adolescent', 'Adult', 'Age Factors', 'Aged', 'Child', 'Child, Preschool', 'Eye Movements', 'Humans', 'Middle Aged', 'Postoperative Period', 'Predictive Value of Tests', 'Regression Analysis', 'Strabismus', 'Vision, Ocular'] | 11,758,348 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['M01.060.406'], ['M01.060.406.448'], ['G11.427.410.140', 'G14.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E04.614.750', 'N02.421.585.753.750'], ['E05.318.370.800.650', 'N05.715.360.325.700... | ['Named Groups [M]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A Sporadic Case of Charcot-Marie-Tooth Disease Type 2 with Left Vocal Fold Palsy due to Mitofusin 2 Mutation. | A 33-year-old Japanese woman was referred for hoarseness. She had been diagnosed with Charcot-Marie-Tooth disease at age 3 and bilateral optic atrophy at age 15. Laryngoscopy revealed left vocal fold palsy. These findings suggested Charcot-Marie-Tooth disease type 2; the diagnosis was confirmed by a mitofusin 2 mutatio... | ['Adolescent', 'Adult', 'Charcot-Marie-Tooth Disease', 'Child, Preschool', 'DNA Mutational Analysis', 'Female', 'GTP Phosphohydrolases', 'Humans', 'Mitochondrial Proteins', 'Optic Atrophy', 'Vocal Cord Paralysis'] | 30,996,168 | [['M01.060.057'], ['M01.060.116'], ['C10.500.300.200', 'C10.574.500.495.200', 'C10.668.829.800.300.200', 'C16.131.666.300.200', 'C16.320.400.375.200'], ['M01.060.406.448'], ['E05.393.760.700.300'], ['D08.811.277.040.330'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.575'], ['C10.292.700.225', 'C11.640.45... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Polyphenolic compounds and antioxidant activity of new and old apple varieties. | There is considerable evidence to show that a greater intake of apple contributes to improved health by reducing the risk of diseases, such as cardiovascular disease and some forms of cancer. Apple fruit is a major source of phenol compounds, because its consumption is widespread in many countries and it is available o... | ['Antioxidants', 'Chromatography, High Pressure Liquid', 'Flavonoids', 'Fruit', 'Malus', 'Phenols', 'Polyphenols', 'Species Specificity'] | 18,611,028 | [['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['E05.196.181.400.300'], ['D03.383.663.283.266.450', 'D03.633.100.150.266.450'], ['A18.024.500', 'G07.203.300.562', 'J02.500.562'], ['B01.650.940.800.575.912.250.859.937.500.444'], ['D02.455.426.559.389.657'], ['D02.455.426.559.389.657.715', 'D03.633.100.1... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Enantioselective intramolecular aldehyde á-alkylation with simple olefins: direct access to homo-ene products. | A highly selective method for the synthesis of asymmetrically substituted carbocycles and heterocycles from unactivated aldehyde-olefin precursors has been achieved via enantioselective SOMO-catalysis. Addition of a catalytically generated enamine radical cation across a pendent olefin serves to establish a general asy... | ['Aldehydes', 'Alkenes', 'Alkylation', 'Amines', 'Molecular Structure', 'Stereoisomerism'] | 23,745,728 | [['D02.047'], ['D02.455.326.271'], ['G02.111.035', 'G02.607.094', 'G03.059'], ['D02.092'], ['G02.111.570', 'G02.466'], ['G02.607.445.682']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Tanshinone IIA inhibits â-catenin/VEGF-mediated angiogenesis by targeting TGF-â1 in normoxic and HIF-1á in hypoxic microenvironments in human colorectal cancer. | In a previous study, we demonstrated that Tanshinone IIA effectively inhibits CRC angiogenesis in vivo, but the underlying mechanisms were not elucidated. In this report, we describe experiments in which HIF-1á levels were manipulated to probe the effect of hypoxia on CRC cell angiogenesis. We studied the effects of Ta... | ['Abietanes', 'Angiogenesis Inhibitors', 'Animals', 'Basic Helix-Loop-Helix Transcription Factors', 'Cell Movement', 'Cell Proliferation', 'Chick Embryo', 'Colorectal Neoplasms', 'Dose-Response Relationship, Drug', 'Female', 'Fibroblast Growth Factor 2', 'HCT116 Cells', 'HT29 Cells', 'Human Umbilical Vein Endothelial C... | 28,602,978 | [['D02.455.426.559.847.723.040', 'D02.455.849.291.040', 'D04.615.723.040'], ['D27.505.696.377.077.099', 'D27.505.696.377.450.100', 'D27.505.954.248.025'], ['B01.050'], ['D12.776.260.103', 'D12.776.930.125'], ['G04.198', 'G07.568.500.180'], ['G04.161.750', 'G07.345.249.410.750'], ['A13.350.150', 'A16.331.200'], ['C04.58... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Heterogeneity of estrogen binding sites in breast cancer: morphologic demonstration and relationship to endocrine response. | Breast cancer specimens from 184 patients were analyzed for estrogen binding by two different histochemical techniques using conjugates of estradiol, bovine serum albumin, and fluorescein. In one conjugate estradiol was bound at position 6, in the other at position 17. Results were in agreement in 64% (p less than .001... | ['Binding Sites', 'Breast Neoplasms', 'Cell Nucleus', 'Cytoplasm', 'Estradiol', 'Female', 'Fluorescein', 'Fluoresceins', 'Histocytochemistry', 'Humans', 'Immunologic Techniques', 'Methods', 'Radioligand Assay', 'Receptors, Estrogen', 'Serum Albumin, Bovine'] | 3,893,573 | [['G02.111.570.120'], ['C04.588.180', 'C17.800.090.500'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['A11.284.430.214'], ['D04.210.500.365.415.248', 'D06.472.334.851.437.500'], ['D02.455.426.779.347.390', 'D03.633.300.953.275.390', 'D04.711.347.390'], ['D02.455.426.779.347', 'D03.633.300.953.275', 'D04.711.34... | ['Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
[Plasmid pBR322 drug-resistance gene changes induced by glycidyl methacrylate]. | A mutagen, glycidyl methacrylate (GMA), discovered by us a few years ago has been used to investigate the mutation mechanism of drug-resistance genes of plasmid pBR322. The results indicated that GMA binds strongly to pBR322 DNA, and this binding decreased the relative transformation efficiency using E. coli HB1O1 stra... | ['Ampicillin Resistance', 'Epoxy Compounds', 'Methacrylates', 'Mutation', 'R Factors', 'Tetracycline Resistance'] | 1,839,530 | [['G06.099.225.500.600.050', 'G06.225.347.500.600.050', 'G07.690.773.984.269.347.500.600.050'], ['D02.355.291.411'], ['D02.241.081.069.600'], ['G05.365.590'], ['G05.360.600.600'], ['G06.099.225.937', 'G06.225.347.937', 'G07.690.773.984.269.347.937']] | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Kv7.2 regulates the function of peripheral sensory neurons. | The Kv7 (KCNQ) family of voltage-gated K(+) channels regulates cellular excitability. The functional role of Kv7.2 has been hampered by the lack of a viable Kcnq2-null animal model. In this study, we generated homozygous Kcnq2-null sensory neurons using the Cre-Lox system; in these mice, Kv7.2 expression is absent in t... | ['Animals', 'Cell Adhesion Molecules, Neuronal', 'Female', 'Ganglia, Spinal', 'Gene Expression Regulation', 'Hyperalgesia', 'KCNQ2 Potassium Channel', 'KCNQ3 Potassium Channel', 'Male', 'Membrane Potentials', 'Mice', 'Mice, Knockout', 'Motor Activity', 'Mutation', 'Nerve Tissue Proteins', 'PAX3 Transcription Factor', '... | 24,687,876 | [['B01.050'], ['D12.776.395.550.200.250', 'D12.776.543.550.200.250', 'D23.050.301.350.250'], ['A08.340.390.340', 'A08.800.350.340', 'A08.800.800.720.725.350'], ['G05.308'], ['C10.597.751.791.400', 'C23.888.592.763.770.400'], ['D12.776.157.530.400.600.900.124.249.750', 'D12.776.543.550.450.750.900.124.249.750', 'D12.776... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Characterization of the human RB1 promoter and of elements involved in transcriptional regulation. | The retinoblastoma gene (RB1) is a recessive oncogene implicated in a number of human tumors. Although the RB1 gene is expressed in most proliferating cells, there is considerable evidence for the transcriptional regulation of this gene. Therefore, we have performed a detailed analysis of the regulatory elements in the... | ['Activating Transcription Factors', 'Base Sequence', 'Binding Sites', 'Blood Proteins', 'DNA', 'Genes, Retinoblastoma', 'Humans', 'Molecular Sequence Data', 'Neoplasm Proteins', 'Peptide Elongation Factor 2', 'Peptide Elongation Factors', 'Promoter Regions, Genetic', 'RNA, Messenger', 'Retinoblastoma Protein', 'Sequen... | 8,049,153 | [['D12.776.260.108.061', 'D12.776.930.127.061'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G02.111.570.120'], ['D12.776.124'], ['D13.444.308'], ['G05.360.340.024.340.375.249.400', 'G05.360.340.024.340.415.400.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.453.245.667'], ['D12.776.624']... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Malignant eccrine poroma in breast cancer-related lymphoedema. | We describe the first case of malignant eccrine poroma arising in a lymphoedematous site. The patient had long-standing lymphoedema of the upper limb following breast cancer treatment. Lymphoedema is a recognised complication of breast cancer treatment and a risk factor for the subsequent development of malignancy. Pos... | ['Aged', 'Breast Neoplasms', 'Eccrine Glands', 'Female', 'Humans', 'Lymphedema', 'Neoplasm Metastasis', 'Neoplasm Recurrence, Local', 'Sweat Gland Neoplasms'] | 16,749,962 | [['M01.060.116.100'], ['C04.588.180', 'C17.800.090.500'], ['A10.336.899.480', 'A17.815.830.480'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C15.604.496'], ['C04.697.650', 'C23.550.727.650'], ['C04.697.655', 'C23.550.727.655'], ['C04.588.805.776', 'C17.800.882.743', 'C17.800.946.743']] | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Foreign born status and HIV/AIDS: a comparative analysis of HIV/AIDS characteristics among foreign and U.S. born individuals. | The purpose of this study was to observe differences in HIV characteristics between the foreign and U.S. born HIV population. The study sample consisted of individuals, ?13 years of age, who have been diagnosed with HIV and are patients of the Lexington Bluegrass Care Clinic. For the comparison analysis, the sample was... | ['AIDS-Related Opportunistic Infections', 'Adult', 'CD4 Lymphocyte Count', 'Censuses', 'Female', 'HIV Infections', 'Humans', 'Kentucky', 'Male', 'Medical Audit', 'United States', 'Young Adult'] | 21,327,966 | [['C01.221.250.875.100', 'C01.597.050', 'C01.610.684.050', 'C01.925.597.050', 'C01.925.782.815.616.400.100', 'C20.673.480.100'], ['M01.060.116'], ['E01.370.225.500.195.107.595.500.150', 'E01.370.225.625.107.595.500.150', 'E05.200.500.195.107.595.500.150', 'E05.200.625.107.595.500.150', 'E05.242.195.107.595.500.150', 'G... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Histochemical mapping of hnRNP A2/B1 in rat brain after ischemia-reperfusion insults. | Cerebral ischemia-reperfusion (I/R) insults result in neuronal cell death, brain tissue loss, and severe neurological deficits. However, the underlying mechanism is still not fully understood. Heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1 belongs to a family of RNA-binding proteins that plays a central role in ... | ['Animals', 'Brain', 'Cerebral Cortex', 'Gene Expression Regulation', 'Heterogeneous-Nuclear Ribonucleoprotein Group A-B', 'Hippocampus', 'Immunohistochemistry', 'Male', 'Middle Cerebral Artery', 'Neurons', 'Protein Transport', 'Rats', 'Rats, Sprague-Dawley', 'Reperfusion Injury'] | 20,421,594 | [['B01.050'], ['A08.186.211'], ['A08.186.211.200.885.287.500'], ['G05.308'], ['D12.776.157.725.813.750.100', 'D12.776.260.735.500', 'D12.776.660.235.700.500', 'D12.776.664.962.813.750.100'], ['A08.186.211.180.405', 'A08.186.211.200.885.287.500.345'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.6... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Vascular endothelial growth factor improves recovery of sensorimotor and cognitive deficits after focal cerebral ischemia in the rat. | Vascular endothelial growth factor (VEGF) is an angiogenesis factor with neurotrophic, neuroprotective and neuroproliferative effects. Depending on the dose, route and time of administration in relation to focal cerebral ischemia, VEGF can improve histological outcome and sensorimotor function in rodents. However, VEGF... | ['Animals', 'Blood-Brain Barrier', 'Brain Edema', 'Brain Ischemia', 'Cerebral Cortex', 'Cerebral Infarction', 'Cognition Disorders', 'Disease Models, Animal', 'Infarction, Middle Cerebral Artery', 'Male', 'Maze Learning', 'Movement Disorders', 'Neuroprotective Agents', 'Rats', 'Rats, Sprague-Dawley', 'Recovery of Funct... | 16,928,361 | [['B01.050'], ['A07.035', 'A08.186.211.035'], ['C10.228.140.187'], ['C10.228.140.300.150', 'C14.907.253.092'], ['A08.186.211.200.885.287.500'], ['C10.228.140.300.150.477.200', 'C10.228.140.300.775.200.200', 'C14.907.253.092.477.200', 'C14.907.253.855.200.200', 'C23.550.513.355.250.200', 'C23.550.717.489.250.200'], ['F0... | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Men and women: changing roles and social security. | In the Social Security Amendments of 1977, Congress called for a study to examine ways to eliminate dependency as a factor in determining entitlement to spouse's benefits under the social security program as well as proposals to bring about the equal treatment of men and women. The report of the study undertaken in res... | ['Adolescent', 'Adult', 'Child', 'Female', 'Humans', 'Income', 'Insurance Benefits', 'Male', 'Marriage', 'Men', 'Middle Aged', 'Role', 'Social Change', 'Social Security', 'United States', 'Women'] | 483,119 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Liver and splenic sarcoidosis: diagnostic procedures]. | INTRODUCTION: Clinical studies indicate involvement of the liver and spleen in approximately 20-30% of patients affected with sarcoidosis and their detection should be based on a standardized diagnostic procedure.DIAGNOSTIC PROCEDURES: Ultrasonography is a reliable and safe method to assess changes related to size and ... | ['Adult', 'Aged', 'Aged, 80 and over', 'Female', 'Humans', 'Liver Diseases', 'Male', 'Middle Aged', 'Sarcoidosis', 'Splenic Diseases'] | 15,675,620 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C06.552'], ['M01.060.116.630'], ['C15.604.515.827'], ['C15.604.744']] | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Lack of Association Between TGF-â1 and MDR1 Genetic Polymorphisms and Cyclosporine-Induced Gingival Overgrowth in Kidney Transplant Recipients: A Meta-analysis. | BACKGROUND: Gingival overgrowth (GO) induced by cyclosporine (CsA), one of the common complications after kidney transplantation, is associated with a genetic component. However, the effect of TGF-â1 and MDR1 gene polymorphisms on the pathogenesis of CsA-induced GO remains to be determined. This study aimed to determin... | ['ATP Binding Cassette Transporter, Subfamily B', 'Asian Continental Ancestry Group', 'China', 'Cyclosporine', 'Female', 'Gingival Overgrowth', 'Humans', 'Immunosuppressive Agents', 'Kidney Transplantation', 'Male', 'Odds Ratio', 'Polymorphism, Genetic', 'Postoperative Period', 'Transforming Growth Factor beta1'] | 28,736,004 | [['D12.776.157.530.100.075', 'D12.776.157.530.450.074.500.500.250', 'D12.776.395.550.020.400', 'D12.776.543.550.192.400', 'D12.776.543.585.100.200', 'D12.776.543.585.450.074.500.500.250'], ['M01.686.508.200'], ['Z01.252.474.164'], ['D04.345.566.235.300', 'D12.644.641.235.300'], ['C07.465.714.258.428'], ['B01.050.150.90... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Geographicals [Z]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
[Renal arteriovenous fistula with a vein aneurysm: a case report]. | A 54-year-old woman presented with abdominal distension. Her medical history was unremarkable. Contrast-enhanced computed tomography (CT) revealed a left renal arteriovenous fistula and a large vein aneurysm, and she was diagnosed with aneurismal-type renal arteriovenous fistula. She was successfully treated with trans... | ['Aneurysm', 'Angiography', 'Arteriovenous Fistula', 'Embolization, Therapeutic', 'Female', 'Humans', 'Middle Aged', 'Renal Veins', 'Tomography, X-Ray Computed'] | 25,142,960 | [['C14.907.055'], ['E01.370.350.700.060', 'E01.370.370.050'], ['C14.240.850.750.147', 'C14.240.850.984.750', 'C14.907.150.125', 'C14.907.933.555', 'C16.131.240.850.750.125', 'C23.300.575.950.250'], ['E02.520.360', 'E02.926.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['A07.015.908.752'],... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Impact of pharmacokinetics on the toxicity and efficacy of clofarabine in patients with relapsed or refractory acute myeloid leukemia. | Common side effects of clofarabine (CFB) are liver toxicity, particularly a transient elevation of transaminases and skin toxicity. We studied the correlation of pharmacokinetic (PK) parameters with these toxicities and the efficacy of CFB in patients with relapsed or refractory acute myeloid leukemia. Clofarabine PK p... | ['Adenine Nucleotides', 'Antimetabolites, Antineoplastic', 'Antineoplastic Combined Chemotherapy Protocols', 'Arabinonucleosides', 'Area Under Curve', 'Clofarabine', 'Drug Resistance, Neoplasm', 'Female', 'Humans', 'Leukemia, Myeloid, Acute', 'Liver', 'Liver Function Tests', 'Male', 'Middle Aged', 'Recurrence', 'Skin',... | 28,509,593 | [['D03.633.100.759.646.138', 'D13.695.667.138', 'D13.695.827.068'], ['D27.505.519.186.144', 'D27.505.954.248.144', 'D27.888.569.042.030'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['D13.570.065'], ['E05.318.740.200', 'G03.787.101', 'G07.690.725.064', 'N06.850.520.830.200'], ['D03.633.100.759.646.138.3... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Named Groups [M]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Influence of patient age on normalized effective doses calculated for CT examinations. | Monte Carlo simulations of CT examinations have been performed to estimate effective doses, normalized to axial air kerma, for six mathematical phantoms representing ages from newborn to adult, and for three CT scanner models covering a range of designs. Organ doses were calculated for CT exposures of contiguous, 1 cm ... | ['Adolescent', 'Adult', 'Age Factors', 'Child', 'Child, Preschool', 'Humans', 'Infant', 'Infant, Newborn', 'Monte Carlo Method', 'Phantoms, Imaging', 'Radiation Dosage', 'Tomography, X-Ray Computed'] | 12,381,691 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['E05.318.740.525', 'L01.906.394.422', 'N05.715.360.750.540', 'N06.850.520.830.525'], ['E07.671'], ['E05.799.513', 'G01.... | ['Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Stimulatory effect of oral administration of green tea or caffeine on ultraviolet light-induced increases in epidermal wild-type p53, p21(WAF1/CIP1), and apoptotic sunburn cells in SKH-1 mice. | Pretreatment of SKH-1 mice with p.o.-administered 0.6% green tea (6 mg of lyophilized tea solids/ml) or 0.044% caffeine (0.44 mg/ml; concentration present in 0.6% green tea) for 2 weeks enhanced UV-induced increases in the number of p53-positive cells, p21(WAF1/CIP1)-positive cells, and apoptotic sunburn cells in the e... | ['Adaptation, Biological', 'Administration, Oral', 'Animals', 'Anticarcinogenic Agents', 'Apoptosis', 'Bromodeoxyuridine', 'Caffeine', 'Cell Division', 'Cyclin-Dependent Kinase Inhibitor p21', 'Cyclins', 'DNA', 'Epidermis', 'Female', 'Mice', 'Mice, Hairless', 'Stimulation, Chemical', 'Sunburn', 'Tea', 'Tumor Suppressor... | 10,987,287 | [['G16.012'], ['E02.319.267.100'], ['B01.050'], ['D27.505.696.706.018', 'D27.505.954.248.125', 'D27.720.799.018'], ['G04.146.954.035'], ['D03.383.742.680.852.300.150', 'D13.570.230.430.196', 'D13.570.685.852.300.150'], ['D03.132.960.175', 'D03.633.100.759.758.824.175'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G0... | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
[Acute pulmonary edema secondary to a posterior fossa tumor: report of a case]. | A case of a 44-year-old woman presenting pulmonary edema secondary to posterior fossa meningioma is reported. The authors have tried to demonstrate the relationship between a lesion occupying space in the posterior fossa and important pulmonary abnormality such as interstitial edema based on increasing A-aDO2 (oxygen a... | ['Acute Disease', 'Adult', 'Blood Gas Analysis', 'Brain Neoplasms', 'Cranial Fossa, Posterior', 'Female', 'Humans', 'Intracranial Pressure', 'Meningioma', 'Pulmonary Edema'] | 7,125,949 | [['C23.550.291.125'], ['M01.060.116'], ['E01.370.225.124.100.100', 'E01.370.386.700.100', 'E05.200.124.100.100'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['A01.456.830.200', 'A02.835.232.781.750.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G11.561.170.505'], ['C04.557.580.520', 'C04.... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
New onset sarcoid-like granulomatosis developing during anti-TNF therapy: an under-recognised complication. | Tumour necrosis factor-alpha (TNF-a) antagonists have advanced the treatment of inflammatory arthropathies, and are even considered for use in refractory sarcoidosis with some success. Paradoxically, cases of new onset sarcoidosis-like diseases are increasingly reported in patients receiving TNF-a antagonists. Here, we... | ['Adalimumab', 'Adult', 'Antibodies, Monoclonal, Humanized', 'Antirheumatic Agents', 'Arthritis, Psoriatic', 'Arthritis, Rheumatoid', 'Australia', 'Etanercept', 'European Continental Ancestry Group', 'Female', 'Granuloma', 'Humans', 'Immunoglobulin G', 'Kidney', 'Lymph Nodes', 'Male', 'Middle Aged', 'Nephritis, Interst... | 22,389,903 | [['D12.776.124.486.485.114.224.060.250', 'D12.776.124.790.651.114.224.060.250', 'D12.776.377.715.548.114.224.200.250'], ['M01.060.116'], ['D12.776.124.486.485.114.224.060', 'D12.776.124.790.651.114.224.060', 'D12.776.377.715.548.114.224.200'], ['D27.505.954.329'], ['C05.116.900.853.625.800.424', 'C05.550.114.145', 'C05... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Diseases [C]', 'Geographicals [Z]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
Genetic rearrangements of plasmids containing mtDNA inserts: possible poison sequence. | Restriction mapping of recombinant plasmids indicated the presence of poison sequence(s) in monkey mtDNA. These plasmids were constructed from a 5.2 K.b. BglII mtDNA fragment and pRSVneo or pdel9 as cloning vectors. The poison sequence(s) caused genetic rearrangement of the vectors' nucleotide sequences. Deletion of th... | ['Animals', 'Cell Line', 'DNA, Mitochondrial', 'Gene Rearrangement', 'Genetic Vectors', 'Haplorhini', 'Plasmids', 'Restriction Mapping'] | 3,149,953 | [['B01.050'], ['A11.251.210'], ['D13.444.308.283.225'], ['G05.344'], ['G05.360.337'], ['B01.050.150.900.649.313.988.400'], ['G05.360.600'], ['E05.393.183.620.650', 'E05.393.712']] | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Hemorrhage in a cat caused by inhibition of factor XI (plasma thromboplastin antecedent). | A coagulation profile from a 5-year-old neutered male cat with severe epistaxis revealed an intrinsic coagulation defect characterized by prolonged activated partial thromboplastin time, with normal bleeding time, platelet count, and prothrombin time. Subsequent factor XI analyses, using bovine factor XI-deficient plas... | ['Animals', 'Cat Diseases', 'Cats', 'Factor XI Deficiency', 'Hemorrhage', 'Male', 'Peritoneal Diseases'] | 6,833,100 | [['B01.050'], ['C22.180'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['C15.378.100.100.325', 'C15.378.100.141.325', 'C15.378.463.325', 'C16.320.099.325'], ['C23.550.414'], ['C06.844']] | ['Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Genomic characterization of Nontuberculous Mycobacteria. | Mycobacterium tuberculosis and Mycobacterium leprae have remained, for many years, the primary species of the genus Mycobacterium of clinical and microbiological interest. The other members of the genus, referred to as nontuberculous mycobacteria (NTM), have long been underinvestigated. In the last decades, however, th... | ['Chromosome Mapping', 'Gene Transfer, Horizontal', 'Genetic Variation', 'Genome, Bacterial', 'Humans', 'Molecular Sequence Annotation', 'Mycobacterium Infections, Nontuberculous', 'Nontuberculous Mycobacteria', 'Open Reading Frames', 'Phylogeny', 'Sequence Analysis, DNA'] | 28,345,639 | [['E05.393.183'], ['G05.728.390'], ['G05.365'], ['G05.360.340.358.207'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.393.760.479', 'L01.453.245.667.580'], ['C01.150.252.410.040.552.475'], ['B03.510.024.962.500.720', 'B03.510.460.400.410.552.552.720'], ['G05.360.335.760.640', 'G05.360.340.024.340.137.650'], [... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Information Science [L]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
New lipophilic isoniazid derivatives and their 1,3,4-oxadiazole analogues: Synthesis, antimycobacterial activity and investigation of their mechanism of action. | The development of novel drugs is essential for the treatment of tuberculosis and other mycobacterial infections in future. A series of N-alkyl-2-isonicotinoylhydrazine-1-carboxamides was synthesized from isoniazid (INH) and then cyclized to N-alkyl-5-(pyridin-4-yl)-1,3,4-oxadiazole-2-amines. All derivatives were chara... | ['Antitubercular Agents', 'Drug Resistance, Bacterial', 'Hep G2 Cells', 'Humans', 'Isoniazid', 'Microbial Sensitivity Tests', 'Mycobacterium tuberculosis', 'Oxadiazoles', 'Tuberculosis'] | 29,679,902 | [['D27.505.954.122.085.255'], ['G06.099.225', 'G06.225.347', 'G07.690.773.984.269.347'], ['A11.251.860.180.432', 'A11.436.348.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.442.436', 'D03.066.349.410', 'D03.383.725.394.582'], ['E01.370.225.875.595', 'E05.200.875.595', 'E05.337.550.400'], ['B03.510.024.96... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Inter- and intra-tester reliability of the Balance Performance Monitor in a non-patient population. | BACKGROUND AND PURPOSE: There is a growing interest in the measurement and evaluation of balance deficits and a number of instruments for measurement are now available. However, few data exist that accurately describe the reliability when using these measurement tools. This study was designed to evaluate the inter- and... | ['Adult', 'Female', 'Humans', 'Male', 'Observer Variation', 'Postural Balance', 'Sensation Disorders'] | 9,648,178 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.354.753', 'N02.421.450.600', 'N05.715.350.150.675', 'N06.850.490.500.250'], ['F02.830.816.541.752', 'G07.888.750.500', 'G11.427.690', 'G11.561.790.541.595'], ['C10.597.751', 'C23.888.592.763']] | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Both interaction surfaces within cohesin's hinge domain are essential for its stable chromosomal association. | BACKGROUND: The cohesin complex that mediates sister chromatid cohesion contains three core subunits: Smc1, Smc3, and Scc1. Heterotypic interactions between Smc1 and Smc3 dimerization domains create stable V-shaped Smc1/Smc3 heterodimers with a hinge at the center and nucleotide-binding domains (NBDs) at the ends of ea... | ['Amino Acid Sequence', 'Cell Cycle Proteins', 'Chromatids', 'Chromatography, Gel', 'Chromosomal Proteins, Non-Histone', 'Crystallization', 'Dimerization', 'Models, Molecular', 'Molecular Sequence Data', 'Mutation', 'Protein Structure, Tertiary', 'Schizosaccharomyces pombe Proteins', 'Species Specificity', 'Yeasts'] | 20,153,193 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D12.776.167'], ['A11.284.430.106.279.345.190.160.175', 'G05.360.160.175'], ['E05.196.181.400.250'], ['D12.776.660.235', 'D12.776.664.235'], ['E05.196.300', 'G02.171'], ['G02.206', 'G03.230'], ['E05.599.595'], ['L01.453.245.667'], ['G05.365.590'], ['G02.111.570.820.709.610'... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
[Ecoepidemiology of urban schistosomiasis in Itamarac? Island, Pernambuco, Brazil]. | INTRODUCTION: In 1988, 22 autochthonous cases from accidental exposure were registered in Forte Orange beach, Itamarac? Island, Pernambuco, Brazil. All cases occurred in middle-to-upper class individuals who were vacationing in the island. After the cases were identified, the major objective was to find breeding sites ... | ['Animals', 'Biomphalaria', 'Brazil', 'Climate', 'Disease Reservoirs', 'Disease Vectors', 'Ecosystem', 'Endemic Diseases', 'Epidemiologic Factors', 'Humans', 'Mollusca', 'Population Density', 'Schistosoma mansoni', 'Schistosomiasis mansoni', 'Seasons', 'Urban Health'] | 10,973,151 | [['B01.050'], ['B01.050.500.644.400.750.185'], ['Z01.107.757.176'], ['G16.500.275.071', 'N06.230.300.100.250'], ['N06.850.520.203.250'], ['N06.850.335.188', 'N06.850.520.203.375'], ['G16.500.275.157', 'N06.230.124'], ['N06.850.392'], ['N05.715.350', 'N06.850.490'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01... | ['Organisms [B]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Modulation of lithium-pilocarpine-induced status epilepticus by adenosinergic agents. | Effect of adenosinergic agents were investigated in lithium-pilocarpine-induced status epilepticus (SE) in rats. Adenosinergic agents such as adenosine (50, 100 mg/kg), 2-choloroadenosine (1, 2 mg/kg), carbamazepine (20, 80 mg/kg), N6-cyclohexyladenosine (1, 2 mg/kg) and dipyridamole (10, 20 mg/kg) produced theophyllin... | ['2-Chloroadenosine', 'Adenosine', 'Animals', 'Anticonvulsants', 'Carbamazepine', 'Dipyridamole', 'Disease Models, Animal', 'Dose-Response Relationship, Drug', 'Lithium', 'Male', 'Pilocarpine', 'Rats', 'Rats, Wistar', 'Status Epilepticus', 'Theophylline', 'Vasodilator Agents'] | 9,379,781 | [['D03.633.100.759.590.138.300', 'D13.570.583.138.300', 'D13.570.800.096.300'], ['D03.633.100.759.590.138', 'D13.570.583.138', 'D13.570.800.096'], ['B01.050'], ['D27.505.954.427.080'], ['D03.633.300.240.127'], ['D03.383.742.175'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['G07.690.773.875', 'G07.690.936.500'], ['... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Spousal bereavement--implications for health. | BACKGROUND: Bereavement is a potential medical problem as it has implications for health through possible associations with morbidity and mortality.OBJECTIVE: The aim of the present study was to ascertain if spousal bereavement is associated with physical and psychological parameters of illness.METHODS: A spousal berea... | ['Adaptation, Psychological', 'Adult', 'Age Distribution', 'Aged', 'Bereavement', 'Causality', 'Disease', 'Drug Prescriptions', 'England', 'Family Practice', 'Female', 'Health Status', 'Humans', 'Male', 'Mental Disorders', 'Middle Aged', 'Office Visits', 'Sex Distribution', 'Spouses', 'Widowhood'] | 11,739,348 | [['F01.058'], ['M01.060.116'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['M01.060.116.100'], ['F01.470.142'], ['N05.715.350.200', 'N06.850.490.625'], ['C23.550.288'], ['E02.319.307', 'N02.421.668.778.500'], ['Z01.542.363.300'], ['H02.403.340.500'], ['I01.240.425', 'N01.224.425', 'N06.850.505.400.425'], ['... | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Disciplines and Occupations [H]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Role of recycling in improving the performance of chromatographic solvent gradient purifications. | With significant advancement in the upstream processing technology, downstream processing of large bio-molecules is becoming the bottle-neck in the production chain. To face this challenge, design and development of efficient separation processes has become crucial. As a step towards boosting the performance of a chrom... | ['Calcitonin', 'Chromatography, Liquid', 'Conservation of Natural Resources', 'Solvents'] | 18,243,221 | [['D06.472.699.150', 'D06.472.931.052', 'D12.644.400.095', 'D12.644.548.150', 'D12.776.631.650.095'], ['E05.196.181.400'], ['J01.256', 'N06.230.080'], ['D27.720.844']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Portable lead analyzer to locate source of lead. | OBJECTIVE: To investigate the sources of lead in the environment in children with elevated blood, with the help of a Field Portable X-Ray Fluorescence Analyzer.METHODS: One hundred and seven school children were chosen for this study on a random basis, from Mangalore and Karnataka. Their blood lead was analyzed. Of the... | ['Child', 'Environmental Exposure', 'Environmental Monitoring', 'Fluorescence', 'Humans', 'India', 'Lead', 'Soil Pollutants'] | 15,226,557 | [['M01.060.406'], ['N06.850.460.350'], ['N06.850.460.350.080', 'N06.850.780.375'], ['G01.358.500.505.650.665.500', 'G01.590.540.665.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.245.393'], ['D01.268.556.435', 'D01.552.544.435'], ['D27.888.284.756']] | ['Named Groups [M]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Geographicals [Z]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Improved quality of life with an implantable pump for liver perfusion. | In spite of the current discussion on whether liver perfusion is effective (Grage et al. 1979; Ansfield et al. 1975), the implantable perfusion pump offers the possibility of combining the still questionable therapeutic success with a high quality of life during the time remaining to such patients. | ['Antineoplastic Agents', 'Colonic Neoplasms', 'Combined Modality Therapy', 'Hepatectomy', 'Humans', 'Infusions, Intra-Arterial', 'Liver Neoplasms', 'Quality of Life', 'Rectal Neoplasms'] | 6,648,016 | [['D27.505.954.248'], ['C04.588.274.476.411.307.180', 'C06.301.371.411.307.180', 'C06.405.249.411.307.180', 'C06.405.469.158.356.180', 'C06.405.469.491.307.180'], ['E02.186'], ['E04.210.556'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.267.510.520'], ['C04.588.274.623', 'C06.301.623', 'C06.552.697'], ['... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Indolizine derivatives as HIV-1 VIF-ElonginC interaction inhibitors. | Compound 1 (VEC-5) was identified as a potent small-molecular HIV-1 viron infectivity factor inhibitor that targets the viron infectivity factor-ElonginC interaction. A structure-activity relationship study was carried out to develop compounds with improved efficacy against HIV-1 and 49 indolizine derivatives of three ... | ['Anti-HIV Agents', 'Elongin', 'HIV-1', 'Humans', 'Indolizines', 'Protein Binding', 'Structure-Activity Relationship', 'Transcription Factors', 'vif Gene Products, Human Immunodeficiency Virus'] | 23,405,965 | [['D27.505.954.122.388.077.088'], ['D12.776.260.197', 'D12.776.930.215'], ['B04.820.650.589.650.350.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.633.100.496'], ['G02.111.679', 'G03.808'], ['G02.111.830', 'G07.690.773.997'], ['D12.776.930'], ['D12.776.964.775.468.500', 'D12.776.964.775.562.781', 'D12.77... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A novel intrahepatic arterial chemotherapy after radical resection for advanced hepatocellular carcinoma. | BACKGROUND/AIMS: Advanced hepatocellular carcinoma (HCC) with portal vein invasion and/or intrahepatic metastasis has an unfavorable prognosis even after radical hepatic resection. The aim of this study was to evaluate the effectiveness of a novel postoperative adjuvant chemotherapy given through the hepatic artery and... | ['Aged', 'Antineoplastic Combined Chemotherapy Protocols', 'Carcinoma, Hepatocellular', 'Catheters, Indwelling', 'Chemotherapy, Adjuvant', 'Cisplatin', 'Combined Modality Therapy', 'Disease Progression', 'Drug Administration Schedule', 'Female', 'Fluorouracil', 'Hepatectomy', 'Humans', 'Infusions, Intra-Arterial', 'Liv... | 15,966,221 | [['M01.060.116.100'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['E07.132.500'], ['E02.186.170', 'E02.319.170'], ['D01.210.375', 'D01.625.125', 'D01.710.100'], ['E02.186'], ['C23.550.291.656'], ['E02.319.283'], ['... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Transformation of vestibular signals by cerebral cortical neurons in the cat]. | Extracellular unit activity of cortical vestibular projections was recorded in wakeful, immobilized and artificially respirated cats. Natural vestibular stimulation included both sinusoidal and trapezoidal position profiles in the horizontal plane. Tonic and phasic neurons were discriminated. The responses of phasic ne... | ['Acceleration', 'Animals', 'Cats', 'Cerebral Cortex', 'Evoked Potentials', 'Neural Inhibition', 'Neurons', 'Rotation', 'Vestibule, Labyrinth'] | 3,502,286 | [['G01.482.107'], ['B01.050'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['A08.186.211.200.885.287.500'], ['G07.265.216.500', 'G11.561.200.500'], ['G07.265.755', 'G11.561.616'], ['A08.675', 'A11.671'], ['G01.482.703'], ['A09.246.300.909']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of an abnormal mini-mental state examination score on postoperative outcomes in geriatric surgical patients: a meta-analysis. | BACKGROUND: Perioperative cognitive impairment (CI) following surgeries is prevalent in geriatric surgical population aged 60 and older. This meta-analysis was designed to investigate whether the Mini-Mental State Examination (MMSE) has prognostic value on adverse outcomes in aged surgical patients.METHODS: PubMed, Coc... | ['Aged', 'Aged, 80 and over', 'Cognitive Dysfunction', 'Emergence Delirium', 'Geriatrics', 'Humans', 'Mental Status and Dementia Tests', 'Prospective Studies', 'Randomized Controlled Trials as Topic', 'Retrospective Studies', 'Treatment Outcome'] | 31,092,206 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['F03.615.250.700'], ['C10.597.606.337.500.500', 'C23.550.767.181', 'C23.888.592.604.339.500.500', 'F01.700.250.500.500', 'F03.615.350.500'], ['H02.403.355'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F04.711.513.603'], ['E05.318.372.500.750.625', 'N05.715.360.330... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Biodegradation of mixed pesticides by mixed pesticide enriched cultures. | This paper discusses the degradation kinetics of mixed (lindane, methyl parathion and carbofuran) pesticides by mixed pesticide enriched cultures (MEC) under various environmental conditions. The bacterial strains isolated from the mixed microbial consortium were identified as Pseudomonas aeruginosa (MTCC 9236), Bacill... | ['Bacillus', 'Biodegradation, Environmental', 'Carbofuran', 'Chryseobacterium', 'Glucose', 'Hexachlorocyclohexane', 'Kinetics', 'Methyl Parathion', 'Pesticides', 'Pseudomonas aeruginosa', 'Soil Pollutants', 'Water Pollutants, Chemical'] | 19,089,711 | [['B03.300.390.400.158.218', 'B03.353.500.100.218', 'B03.510.100.100.218', 'B03.510.415.400.158.218', 'B03.510.460.410.158.218'], ['N06.230.080.600.500', 'N06.850.460.375.500'], ['D02.241.081.251.583.166'], ['B03.440.080.190.120', 'B03.440.400.425.310.120'], ['D09.947.875.359.448'], ['D02.455.526.439.600'], ['G01.374.6... | ['Organisms [B]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Nonlethal management of baboons on the urban edge of a large metropole. | The transformation of natural land for agricultural and urban use has displaced baboons from large parts of their historical distribution. Abundant resources within transformed areas, however, continue to attract baboons back into these human-dominated areas resulting in chronic levels of conflict throughout much of Af... | ['Animals', 'Cities', 'Conservation of Natural Resources', 'Diet', 'Ecosystem', 'Feeding Behavior', 'Female', 'Human Activities', 'Humans', 'Male', 'Papio ursinus', 'South Africa'] | 32,602,204 | [['B01.050'], ['G16.500.275.069', 'N06.230.069', 'Z01.433'], ['J01.256', 'N06.230.080'], ['G07.203.650.240'], ['G16.500.275.157', 'N06.230.124'], ['F01.145.113.547', 'F01.145.407', 'G07.203.650.353'], ['I03'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649.313.988.400.112.199.120.610.800'], ['Z0... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Geographicals [Z]', 'Technology, Industry, and Agriculture [J]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 |
Cross-sectional study of perioperative drug and allergen exposure in UK practice in 2016: the 6th National Audit Project (NAP6) Allergen Survey. | BACKGROUND: Details of the current UK drug and allergen exposure were needed for interpretation of reports of perioperative anaphylaxis to the 6th National Audit Project (NAP6).METHODS: We performed a cross-sectional survey of 356 NHS hospitals determining anaesthetic drug usage in October 2016. All cases cared for by ... | ['Allergens', 'Anaphylaxis', 'Anesthetics', 'Cross-Sectional Studies', 'Drug Hypersensitivity', 'Drug-Related Side Effects and Adverse Reactions', 'Humans', 'Medical Audit', 'Perioperative Period', 'Registries', 'Surveys and Questionnaires', 'United Kingdom'] | 29,935,566 | [['D23.050.063'], ['C20.543.480.099'], ['D27.505.696.277.100', 'D27.505.954.427.210.100'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['C20.543.206', 'C25.100.468'], ['C25.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N04.761.700.250.500', 'N05.700.175.500'], ['E04.614', ... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Nonexpanded primary lung and bone marrow-derived mesenchymal cells promote the engraftment of umbilical cord blood-derived CD34(+) cells in NOD/SCID mice. | OBJECTIVE: Previously, we have found that human culture-expanded fetal lung-derived mesenchymal stem cells (MSC) promote the engraftment of umbilical cord blood (UCB)-derived CD34((+)) cells. The high frequency of MSC in fetal lung allowed us to study whether this represented a biological feature of these cells or a pr... | ['Animals', 'Antigens, CD34', 'Bone Marrow Transplantation', 'Cell Movement', 'Fetal Blood', 'Hematopoietic Stem Cell Transplantation', 'Humans', 'Immunophenotyping', 'Liver', 'Lung', 'Mesoderm', 'Mice', 'Mice, Nude', 'Mice, SCID'] | 14,550,803 | [['B01.050'], ['D23.050.301.264.035.134', 'D23.101.100.110.134'], ['E02.095.147.725.040', 'E04.936.580.040'], ['G04.198', 'G07.568.500.180'], ['A12.207.152.200', 'A15.145.300', 'A16.378.200'], ['E02.095.147.500.500.500', 'E04.936.225.687.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.812.447', 'E... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
17 alpha-hydroxylase deficiency in a genetic male and female sibling pair. | The diagnosis of congenital adrenal hyperplasia due to a deficiency of the enzyme 17 alpha-hydroxylase was made in a genetic male and female sibling pair born of parents who were first cousins. The genetic male was a phenotypic female who presented with primary amenorrhea and mild hypertension. The genetic female exhib... | ['Adolescent', 'Adrenal Hyperplasia, Congenital', 'Child', 'Chromosome Aberrations', 'Chromosome Disorders', 'Diagnosis, Differential', 'Disorders of Sex Development', 'Female', 'Genes, Recessive', 'Gonadal Steroid Hormones', 'Humans', 'Male', 'Prednisone', 'Steroid Hydroxylases'] | 6,121,730 | [['M01.060.057'], ['C12.706.316.090.500', 'C13.351.875.253.090.500', 'C16.131.939.316.129.500', 'C16.320.033', 'C16.320.565.925.249', 'C18.452.648.925.249', 'C19.053.440', 'C19.391.119.090.500'], ['M01.060.406'], ['C23.550.210', 'G05.365.590.175'], ['C16.131.260', 'C16.320.180'], ['E01.171'], ['C12.706.316', 'C13.351.8... | ['Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
MRI-based Protocol to Characterize the Relationship Between Bicuspid Aortic Valve Morphology and Hemodynamics. | Bicuspid aortic valve (BAV) is the most common congenital heart defect and can lead to severe complications. Many studies have been conducted to evaluate the potential of geometric and hemodynamic biomarkers to predict BAV-related aortopathy. This work proposes a novel semi-automatic protocol to characterize geometry a... | ['Adult', 'Aortic Valve', 'Bicuspid Aortic Valve Disease', 'Blood Flow Velocity', 'Female', 'Heart Valve Diseases', 'Humans', 'Magnetic Resonance Angiography', 'Male', 'Middle Aged', 'Models, Cardiovascular', 'Radiography'] | 25,533,768 | [['M01.060.116'], ['A07.541.510.110'], ['C14.240.400.186', 'C14.280.400.186', 'C14.280.484.048.875', 'C16.131.240.400.186'], ['E01.370.370.130', 'G09.330.380.630.080'], ['C14.280.484'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500.500', 'E01.370.370.050.500'], ['M01.060.116.630'], ['E05.599.39... | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Effect of sodium oxybutyrate on macroergic phosphates, function and ultrastructure of the myocardium in blood loss]. | Experiments on dogs with long-term hypotony caused by blood loss have demonstrated irreversible lesions in the majority of cardiomyocytes and hypodynamic condition of the heart with a high content of macroergic phosphates in the myocardium. Intravenous injection of sodium hydroxybutyrate in a dose of 180-200 mg/kg afte... | ['Adenosine Diphosphate', 'Adenosine Monophosphate', 'Adenosine Triphosphate', 'Animals', 'Creatine', 'Dogs', 'Energy Metabolism', 'Heart', 'Hemodynamics', 'Hemorrhage', 'Hydroxybutyrates', 'Hypotension', 'Myocardium', 'Phosphocreatine', 'Sodium Oxybate'] | 6,704,523 | [['D03.633.100.759.646.138.124', 'D13.695.667.138.124', 'D13.695.827.068.124'], ['D03.633.100.759.646.138.180', 'D13.695.667.138.180', 'D13.695.827.068.180'], ['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['B01.050'], ['D02.078.370.280', 'D12.125.373'], ['B01.050.150.900.649.313.750.250... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Effect of mica monomer granule on gastrin, somatostatin and G cells as well as D cells of gastric mucosa in CAG rat]. | OBJECTIVE: To study regulative action of mica monomer granule preparation on gastrin (GAS), somatostatin (SS) and G cells as well as D cells of gastric mucosa in experimental chronic atrophic gastritis (CAG) rat.METHOD: CAG rats were treated with mica monomer granule preparation with three different dosages--high, mode... | ['Aluminum Silicates', 'Animals', 'Dose-Response Relationship, Drug', 'Gastric Mucosa', 'Gastrin-Secreting Cells', 'Gastrins', 'Gastritis, Atrophic', 'Materia Medica', 'Rats', 'Rats, Sprague-Dawley', 'Somatostatin', 'Somatostatin-Secreting Cells'] | 15,706,923 | [['D01.056.050.075', 'D01.578.725.025', 'D01.650.550.050.075', 'D01.837.725.700.760.050'], ['B01.050'], ['G07.690.773.875', 'G07.690.936.500'], ['A03.556.875.875.440', 'A10.615.550.291'], ['A03.556.875.875.440.300', 'A06.390.065', 'A10.615.550.291.300', 'A11.382.625.055', 'A11.436.294.055'], ['D06.472.317.413', 'D06.47... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Biomechanical Comparison of Arthroscopic Single- and Double-Row Repair Techniques for Acute Bony Bankart Lesions. | BACKGROUND: Single- and double-row arthroscopic reconstruction techniques for acute bony Bankart lesions have been described in the literature.HYPOTHESIS: The double-row fixation technique would provide superior reduction and stability of a simulated bony Bankart lesion at time zero in a cadaveric model compared with t... | ['Adult', 'Arthroscopy', 'Biomechanical Phenomena', 'Cadaver', 'Female', 'Fractures, Bone', 'Humans', 'Male', 'Middle Aged', 'Scapula'] | 25,023,439 | [['M01.060.116'], ['E01.370.388.250.070', 'E04.502.250.070', 'E04.555.113'], ['G01.154.090', 'G01.374.089'], ['C23.550.260.224'], ['C26.404'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['A02.835.232.087.783']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Downregulation of caffeic acid 3-O-methyltransferase and caffeoyl CoA 3-O-methyltransferase in transgenic alfalfa. impacts on lignin structure and implications for the biosynthesis of G and S lignin. | Transgenic alfalfa plants were generated harboring caffeic acid 3-O-methyltransferase (COMT) and caffeoyl CoA 3-O-methyltransferase (CCOMT) cDNA sequences under control of the bean phenylalanine ammonia-lyase PAL2 promoter. Strong downregulation of COMT resulted in decreased lignin content, a reduction in total guaiacy... | ['Base Sequence', 'DNA Primers', 'Fabaceae', 'Lignin', 'Medicago sativa', 'Methyltransferases', 'Plants, Genetically Modified', 'Promoter Regions, Genetic'] | 11,158,530 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['B01.650.940.800.575.912.250.401'], ['D05.750.078.562.180.515', 'D05.750.078.687', 'D20.538', 'D25.720.099.687', 'J01.637.051.720.099.687'], ['B01.650.940.800.575.912.250.401.590.500'], ['D08.811.913... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Microorganisms as antineoplastic agents in CNS tumors. | In two patients, malignant tumors unexpectedly regressed following infections. I reviewed the extensive body of literature, both experimental and clinical, concerning the antineoplastic potential of bacteria and viruses. Substantial evidence exists to indicate that microorganisms may, by growing in or near tumors, comp... | ['Adult', 'Astrocytoma', 'Brain Neoplasms', 'Corynebacterium Infections', 'Female', 'Herpes Zoster', 'Humans', 'Lymphoma, Non-Hodgkin', 'Male', 'Neoplasm Regression, Spontaneous', 'Staphylococcal Infections', 'Tomography, X-Ray Computed'] | 6,688,521 | [['M01.060.116'], ['C04.557.465.625.600.380.080', 'C04.557.470.670.380.080', 'C04.557.580.625.600.380.080'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['C01.150.252.410.040.246'], ['C01.925.256.466.930.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.386.480', 'C15.604.515.569.480'... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Diazobenzene-containing conjugated polymers as dark quenchers. | The synthesis and photophysical characterization of new conjugated polymers (CPs) with alternating phenylethynylene and diazobenzene (azo-PPE) units were reported, which showed broadened absorption and no measurable fluorescence. Quenching studies showed that azo-PPEs displayed high efficiency over a wide wavelength ra... | ['Azo Compounds', 'DNA', 'Fluorescent Dyes', 'Intercalating Agents', 'Polymers', 'Spectrophotometry, Ultraviolet', 'Ultraviolet Rays'] | 24,166,648 | [['D02.172'], ['D13.444.308'], ['D27.720.233.348', 'D27.720.470.410.505.500'], ['D27.720.470.410.360'], ['D05.750', 'D25.720', 'J01.637.051.720'], ['E05.196.712.726.802', 'E05.196.867.826.802'], ['G01.358.500.505.650.891', 'G01.590.540.891', 'G01.750.250.650.891', 'G01.750.750.659', 'G01.750.770.578.891', 'G16.500.275.... | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Influence of magnesium on insulin resistance in obese women. | The present study evaluated the influence of magnesium on insulin resistance in obese women. A case-control study involving 114 women on the age between 20 and 50 years old, divided into two groups: control (eutrophic women, n = 59) and case (obese women, n = 55). The analysis of magnesium intake was carried out throug... | ['Adult', 'Case-Control Studies', 'Female', 'Food Analysis', 'Humans', 'Insulin Resistance', 'Magnesium', 'Middle Aged', 'Nutrition Assessment', 'Obesity'] | 24,984,789 | [['M01.060.116'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['E05.362', 'J01.576.423.850.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C18.452.394.968.500', 'G07.690.773.984.617'], ['D01.268.552.437', 'D01.268.557.500', 'D01.552.547.500'], ['M01.060.116.630'], ['E05.318.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Biochemical and spectroscopic characterization of the high molecular weight cytochrome c from Desulfovibrio vulgaris Hildenborough expressed in Desulfovibrio desulfuricans G200. | The gene of high molecular weight, multiheme cytochrome c (Hmc) from the sulfate-reducing bacterium Desulfovibrio vulgaris Hildenborough has been overexpressed in Desulfovibrio desulfuricans G200. The recombinant protein has been purified. Its molecular weight (65,600), amino acid composition, and NH2-terminal sequence... | ['Amino Acid Sequence', 'Amino Acids', 'Chemical Phenomena', 'Chemistry, Physical', 'Circular Dichroism', 'Cytochrome c Group', 'Desulfovibrio vulgaris', 'Electrochemistry', 'Electron Spin Resonance Spectroscopy', 'Genes, Bacterial', 'Genetic Vectors', 'Heme', 'Iron', 'Molecular Sequence Data', 'Molecular Weight', 'Rec... | 1,313,289 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D12.125'], ['G02'], ['H01.181.529'], ['E05.196.867.151'], ['D08.244.286', 'D12.776.422.220.286'], ['B03.440.425.410.350.875', 'B03.660.125.144.500.875.875', 'B03.900.350.875'], ['H01.181.529.307'], ['E05.196.867.519.274'], ['G05.360.340.024.340.364.249', 'G05.360.340.358.0... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
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