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Identification of EmSOX2, a member of the Sox family of transcription factors, as a potential regulator of Echinococcus multilocularis germinative cells. | Larvae of the tapeworm Echinococcus multilocularis cause alveolar echinococcosis (AE), one of the most lethal helminthic infections in humans. The germinative cells, a population of stem cell-like cells, are considered to drive the continuous growth of the metacestodes within the host. The mechanisms and relative molec... | ['Amino Acid Sequence', 'Animals', 'Cloning, Molecular', 'Echinococcus multilocularis', 'Gene Expression Regulation', 'Genetic Markers', 'HEK293 Cells', 'Humans', 'Reproduction', 'SOXB1 Transcription Factors'] | 28,526,606 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['E05.393.220'], ['B01.050.500.500.736.215.327.500'], ['G05.308'], ['D23.101.387', 'G05.695.450'], ['A11.251.210.172.750', 'A11.436.334'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G08.686.784'], ['D12.776.260.719.100', 'D12.776.660.235.400.750.100', 'D... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Light level induced reorganization of cat's lateral geniculate nucleus receptive fields: a spatiotemporal study. | The spatiotemporal organization of receptive fields (RF) of the cats lateral geniculate cells was investigated under several scotopic and mesopic light adaptation levels, using stationary and moving light stimuli. A given adaptation level was reached by changing of either the diffuse background or the adapting central... | ['Action Potentials', 'Adaptation, Ocular', 'Animals', 'Cats', 'Geniculate Bodies', 'Photic Stimulation', 'Visual Perception'] | 7,325,022 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['G14.020'], ['B01.050'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['A08.186.211.200.317.826.701.444'], ['E05.723.729'], ['F02.463.593.932']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Alcohol consumption and awareness of its effects on health among secondary school students in Nigeria. | Alcohol consumption among secondary school students is a major public health issue worldwide; however, the extent of consumption among secondary school students and their understanding of its effects on human health remain relatively unknown in many Nigerian States. This study aimed to determine the extent of alcohol c... | ['Adolescent', 'Alcohol Drinking', 'Awareness', 'Cross-Sectional Studies', 'Female', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Male', 'Nigeria', 'Self Report', 'Sex Factors', 'Students'] | 29,310,396 | [['M01.060.057'], ['F01.145.317.269'], ['F02.463.188.150'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['F01.100.150.500', 'N05.300.150.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.058.290.190.565'], ['E05.318.308.980.500', 'N05.715.360.300.800.500', 'N06.850.520.308... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Oxytocin and vasopressin genes are significantly associated with schizophrenia in a large Arab-Israeli pedigree. | We have previously studied the genetics of schizophrenia in a large inbred Arab-Israeli pedigree and found evidence for linkage on chromosome 20p13. This locus harbours four strong candidate genes for schizophrenia: atractin (ATRN), pantonate-kinase2 (PANK2), oxytocin (OXT) and arginine-vasopressin (AVP). In this study... | ['Adult', 'Arabs', 'Bipolar Disorder', 'Brain', 'Case-Control Studies', 'Cohort Studies', 'Family', 'Female', 'Gene Expression Regulation', 'Haplotypes', 'Humans', 'Israel', 'Jews', 'Male', 'Membrane Proteins', 'Neurophysins', 'Oxytocin', 'Pedigree', 'Phosphotransferases (Alcohol Group Acceptor)', 'Polymorphism, Single... | 21,899,794 | [['M01.060.116'], ['M01.686.754.167'], ['F03.084.500'], ['A08.186.211'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['F01.829.263', 'I01.880.853.150'], ['G05.308'], ['G05.380.360'], ['B01.050.150.900.649.3... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Geographicals [Z]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Real-time, adaptive machine learning for non-stationary, near chaotic gasoline engine combustion time series. | Fuel efficient Homogeneous Charge Compression Ignition (HCCI) engine combustion timing predictions must contend with non-linear chemistry, non-linear physics, period doubling bifurcation(s), turbulent mixing, model parameters that can drift day-to-day, and air-fuel mixture state information that cannot typically be res... | ['Algorithms', 'Gasoline', 'Machine Learning', 'Models, Neurological', 'Nonlinear Dynamics', 'Support Vector Machine', 'Vehicle Emissions'] | 26,164,437 | [['G17.035', 'L01.224.050'], ['D20.345.630.540', 'N06.230.132.258.630.540'], ['G17.035.250.500', 'L01.224.050.375.530'], ['E05.599.395.642'], ['E05.599.850', 'H01.548.675'], ['G17.035.250.500.500.500', 'L01.224.050.375.530.500.500'], ['D20.832']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Prevalence of respiratory symptoms in Swiss children: is bronchial asthma really more prevalent in boys? | Precise epidemiological data for the prevalence of childhood asthma were lacking for Switzerland until recently. In 1990 we performed a stratified cluster sampling of schoolchildren (aged 7, 12, and 15 years), using a parent completed questionnaire to obtain data for the 12 months prevalence of asthma symptoms and the ... | ['Adolescent', 'Age Distribution', 'Asthma', 'Child', 'Cross-Sectional Studies', 'Female', 'Humans', 'Lung', 'Male', 'Prevalence', 'Sex Distribution', 'Surveys and Questionnaires', 'Switzerland'] | 7,792,118 | [['M01.060.057'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['M01.060.406'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A04.411'], ['E05.318.308.9... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Geographicals [Z]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Water-soluble ions and carbon content of size-segregated aerosols in New Delhi, India: direct and indirect influences of firework displays. | The particle size distribution and water-soluble inorganic ion (WSII) and carbonaceous species in size-segregated aerosols, Dp < 0.95, 0.95 < Dp < 1.5, 1.5 < Dp < 3.0, 3.0 < Dp < 7.2, and 7.2 < Dp < 10 ìm, were investigated during Diwali firework displays in New Delhi, India. The firework activity had the maximum contr... | ['Aerosols', 'Air Pollutants', 'Carbon', 'Environmental Monitoring', 'Fires', 'Games, Recreational', 'India', 'Ions', 'Particle Size', 'Particulate Matter', 'Seasons', 'Solubility', 'Water'] | 27,475,432 | [['D20.280.055', 'D26.255.165.055'], ['D27.888.284.101'], ['D01.268.150'], ['N06.850.460.350.080', 'N06.850.780.375'], ['N06.230.216'], ['I03.450.642.693.465'], ['Z01.252.245.393'], ['D01.248.497'], ['G02.712'], ['D20.633'], ['G01.910.645.661', 'G16.500.275.071.590', 'N06.230.300.100.250.525'], ['G02.805'], ['D01.045.2... | ['Chemicals and Drugs [D]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Mapping RNA interactions to proteins in virions using CLIP-Seq. | RNA nanotechnology often involves protein-RNA complexes that require significant understanding of how the proteins and RNAs contact each other. The CLIP-Seq (cross-linking immunoprecipitation, and DNA sequencing) protocol can be used to probe the RNA molecules that interact with proteins. We have optimized the procedur... | ['Capsid Proteins', 'High-Throughput Nucleotide Sequencing', 'Immunoprecipitation', 'Protein Interaction Mapping', 'RNA, Viral', 'RNA-Binding Proteins', 'Virion'] | 25,896,006 | [['D12.776.964.970.600.550'], ['E05.393.760.319'], ['E05.196.150.639', 'E05.478.605'], ['E05.601.690'], ['D13.444.735.828'], ['D12.776.157.725', 'D12.776.664.962'], ['A21.249']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The effects of several oligosaccharides on growth performance, nutrient digestibilities, and cecal microbial populations in young chicks. | Two experiments were conducted with New Hampshire x Columbian chicks fed a corn-soybean meal diet and 1 experiment was conducted with chicks fed a dextrose-isolated soy protein diet to examine the effects of inulin, oligofructose, mannanoligosaccharide (MOS), short-chain fructooligosaccharide (SCFOS), and transgalactoo... | ['Amino Acids', 'Animal Feed', 'Animal Nutritional Physiological Phenomena', 'Animals', 'Cecum', 'Chickens', 'Diet', 'Dietary Proteins', 'Dietary Supplements', 'Digestion', 'Energy Metabolism', 'Male', 'Oligosaccharides', 'Weight Gain'] | 17,954,582 | [['D12.125'], ['G07.203.300.300.100', 'J02.500.300.100'], ['G07.203.650.161'], ['B01.050'], ['A03.556.124.526.209', 'A03.556.249.249.209'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['G07.203.650.240'], ['D12.776.256', 'G07.203.300.428', 'J02.500.428'], ['G07.203.300.456', 'J02.500.456'], ['G07.20... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Alteration of drug chemosensitivity caused by the adenovirus-mediated transfer of the wild-type p53 gene in human lung cancer cells. | The aim of the present study is to identify the optimal anticancer agents for use in combination with gene therapy using wild-type (wt) p53 gene transfer. We used adenoviral vectors expressing human wt p53 (AdCAp53) and investigated the effects of wt p53 gene transfer in combination with 12 anticancer agents on a human... | ['Adenoviridae', 'Animals', 'Antineoplastic Combined Chemotherapy Protocols', 'Bleomycin', 'Camptothecin', 'Combined Modality Therapy', 'DNA, Recombinant', 'DNA, Viral', 'Drug Resistance, Neoplasm', 'Fluorouracil', 'Gene Transfer Techniques', 'Humans', 'Inhibitory Concentration 50', 'Irinotecan', 'Lung Neoplasms', 'Mic... | 10,770,640 | [['B04.280.030'], ['B01.050'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['D09.400.420.110', 'D12.644.233.110'], ['D03.132.151'], ['E02.186'], ['D13.444.308.460'], ['D13.444.308.568'], ['G07.690.773.984.395'], ['D03.383.742.698.875.404'], ['E05.393.350'], ['B01.050.150.900.649.313.988.400.112.400.400']... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Perceptual experience modulates cortical circuits involved in visual awareness. | Successful interactions with the environment entail interpreting ambiguous sensory information. To address this challenge it has been suggested that the brain optimizes performance through experience. Here we used functional magnetic resonance imaging (fMRI) to investigate whether perceptual experience modulates the co... | ['Adult', 'Awareness', 'Female', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Memory', 'Nerve Net', 'Parietal Lobe', 'Vision Disparity', 'Visual Cortex'] | 23,031,201 | [['M01.060.116'], ['F02.463.188.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['F02.463.425.540'], ['A08.511'], ['A08.186.211.200.885.287.500.670'], ['F02.463.593.778.255.780', 'F02.463.593.932.877', 'G14.930'], ['A08.186.211.200.885.287.500.571.735', 'A08.186.211.200.885.287.500.814.... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Exploring the expanded role of the pharmacy technician in medication therapy management service implementation in the community pharmacy. | OBJECTIVES: To explore the current roles of the pharmacy technician in the provision of medication therapy management (MTM) and their relation to organizational behavior at "high-performing" community pharmacies within a nationwide supermarket chain.DESIGN: Qualitative research study using methodologic triangulation wi... | ['Community Pharmacy Services', 'Humans', 'Interviews as Topic', 'Medication Therapy Management', 'Patient Care', 'Pharmacists', 'Pharmacy Technicians', 'Professional Role', 'Qualitative Research', 'Tennessee', 'Workflow'] | 30,679,031 | [['N02.421.143.221', 'N02.421.668.274'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.420', 'L01.399.250.520', 'N05.715.360.300.400', 'N06.850.520.308.420'], ['N02.421.668.438', 'N03.219.521.576.343.575.500.500', 'N03.219.521.576.343.840.938.500', 'N04.590.661'], ['E02.760', 'N02.421.585'], ['M01.526.... | ['Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Disciplines and Occupations [H]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 |
Nasal Reconstruction Using a Customized Three-Dimensional-Printed Stent for Congenital Arhinia: Three-Year Follow-up. | A male Mongolian child with a complete congenital absence of both nose and nasal passage had a poor survival prognosis due to respiratory distress. To enable his survival, a new nose capable of conferring respiratory function was constructed. Following reconstructive surgery, an absence of mucoepithelium in the nasal p... | ['Child', 'Congenital Abnormalities', 'Follow-Up Studies', 'Humans', 'Male', 'Nose', 'Printing, Three-Dimensional', 'Rhinoplasty', 'Stents', 'Time Factors'] | 30,247,752 | [['M01.060.406'], ['C16.131'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A01.456.505.733', 'A04.531', 'A09.531'], ['J01.897.564', 'L01.224.108.150.500', 'L01.296.110.150.500'], ['E02.218.755', 'E04.580.392.500', 'E04.680... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 0 |
The positive chronotropic effect induced by BRL 37344 and CGP 12177, two beta-3 adrenergic agonists, does not involve cardiac beta adrenoceptors but baroreflex mechanisms. | The presence of a beta-3 adrenoceptor (in addition to the classical beta-1 and beta-2 adrenoceptors) and its involvement in the control of heart rate was investigated in the dog. Experiments were carried out in conscious normal and sinoaortic denervated dogs (i.e. animals deprived of baroreceptor pathways). In normal d... | ['Adipose Tissue', 'Adrenergic beta-Agonists', 'Animals', 'Dogs', 'Ethanolamines', 'Heart Rate', 'Isoproterenol', 'Lipolysis', 'Male', 'Pressoreceptors', 'Propanolamines', 'Receptors, Adrenergic, beta', 'Reflex', 'Stimulation, Chemical'] | 1,361,569 | [['A10.165.114'], ['D27.505.519.625.050.100.200', 'D27.505.696.577.050.100.200'], ['B01.050'], ['B01.050.150.900.649.313.750.250.216.200'], ['D02.033.100.291', 'D02.033.375.291', 'D02.092.063.291'], ['E01.370.600.875.500', 'G09.330.380.500'], ['D02.033.100.291.439', 'D02.092.063.291.439', 'D02.092.311.649', 'D02.455.42... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Clonidine has comparable effects on spontaneous sympathetic activity and afferent A delta and C-fiber-mediated somatosympathetic reflexes in dogs. | BACKGROUND: Clonidine, an alpha 2-adrenergic agonist, has been studied as an adjunct or alternative to spinal opioids in the management of moderate to severe pain. This study examined the relative effects of clonidine on efferent spontaneous sympathetic activity and afferent A delta and C fiber-mediated somatosympathet... | ['Animals', 'Blood Pressure', 'Clonidine', 'Dogs', 'Electric Stimulation', 'Heart Rate', 'Infusions, Intravenous', 'Injections, Intravenous', 'Injections, Spinal', 'Kidney', 'Naloxone', 'Nerve Fibers', 'Nerve Fibers, Myelinated', 'Neurons, Afferent', 'Reflex', 'Sympathetic Nervous System', 'Yohimbine'] | 8,092,517 | [['B01.050'], ['E01.370.600.875.249', 'G09.330.380.076'], ['D03.383.129.308.436.500'], ['B01.050.150.900.649.313.750.250.216.200'], ['E05.723.402'], ['E01.370.600.875.500', 'G09.330.380.500'], ['E02.319.267.082.500', 'E02.319.267.510.590'], ['E02.319.267.082.750', 'E02.319.267.530.540'], ['E02.319.267.530.580'], ['A05.... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The adapter proteins ADAP and Nck cooperate in T cell adhesion. | Nck adapter proteins link receptor and receptor-associated tyrosine kinases with proteins implicated in the regulation of the actin cytoskeleton. Nck is involved in a multitude of receptor-initiated signaling pathways and its physiological role thus covers aspects of tissue development and homeostasis, malignant transf... | ['Actin Cytoskeleton', 'Adaptor Proteins, Signal Transducing', 'Cell Adhesion', 'Cell Line', 'Enzyme Activation', 'HEK293 Cells', 'Humans', 'Integrins', 'Intercellular Adhesion Molecule-1', 'Lymphocyte Function-Associated Antigen-1', 'Oncogene Proteins', 'Phosphorylation', 'Protein Structure, Tertiary', 'RNA Interferen... | 24,769,494 | [['A11.284.430.214.190.750.050'], ['D12.644.360.024', 'D12.776.157.057', 'D12.776.476.024'], ['G04.022'], ['A11.251.210'], ['G02.111.263', 'G03.328'], ['A11.251.210.172.750', 'A11.436.334'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.543.750.705.408'], ['D12.776.395.550.200.450', 'D12.776.543.550.200.45... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Solid- and liquid-phase extraction for the gas chromatographic-tandem mass spectrometric quantification of 2,3-dinor-thromboxane B2 and 2,3-dinor-6-oxo-prostaglandin F1 alpha in human urine. | Whole body synthesis of thromboxane A2 is best assessed by quantifying non-invasively its major urinary metabolite, i.e., 2,3-dinor-thromboxane B2 (2,3-dn-TxB2), by gas chromatography-mass spectrometry (GC-MS) or GC-tandem MS. Methods based on these techniques usually require a series of extraction and purification pro... | ['6-Ketoprostaglandin F1 alpha', 'Chromatography, Thin Layer', 'Gas Chromatography-Mass Spectrometry', 'Humans', 'Reference Values', 'Reproducibility of Results', 'Sensitivity and Specificity', 'Thromboxane B2'] | 10,941,682 | [['D10.251.355.255.550.400.350', 'D10.251.355.325.450', 'D23.469.050.175.725.400.350'], ['E05.196.181.400.537'], ['E05.196.181.349.500', 'E05.196.566.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.978.810'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['E05.318.370.8... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Sequence analysis and minimal replicon determination of a new haloarchaeal plasmid pHF2 isolated from Haloferax sp. strain Q22. | A new cryptic plasmid, pHF2 (2520 bp), was isolated from Haloferax sp. strain Q22 (CGMCC 1.15317), a haloarchaeal strain living in a subterranean halite deposit. Sequence analysis revealed that it is the smallest plasmid in the genus Haloferax so far, and three syntropic open reading frames (ORF1, ORF2, and ORF3) were ... | ['Amino Acid Sequence', 'Bacterial Proteins', 'Base Sequence', 'Geologic Sediments', 'Haloferax', 'Molecular Sequence Data', 'Open Reading Frames', 'Plasmids', 'RNA, Ribosomal, 16S', 'Replicon', 'Sequence Analysis, DNA', 'Sequence Homology, Amino Acid'] | 26,601,892 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D12.776.097'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G01.311.330', 'G16.500.320'], ['B02.200.400.400.440'], ['L01.453.245.667'], ['G05.360.335.760.640', 'G05.360.340.024.340.137.650'], ['G05.360.600'], ['D13.444.735.686.670'], ['G05.360.340.024.745']... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Ginsenosides Rb1 and Rg1 effects on mesencephalic dopaminergic cells stressed with glutamate. | Ginseng, the root of Panax ginseng C.A. Meyer (Araliaceae), is a well known and popular herbal medicine used worldwide. Among more than 30 ginsenosides, the active ingredients of ginseng, ginsenosides Rb1 and Rg1 are regarded as the main compounds responsible for many pharmaceutical actions of ginseng. In our study, pr... | ['Animals', 'Cells, Cultured', 'Central Nervous System Agents', 'Coloring Agents', 'DNA Fragmentation', 'Dizocilpine Maleate', 'Dopamine', 'Excitatory Amino Acid Antagonists', 'Female', 'Ginsenosides', 'Glutamic Acid', 'L-Lactate Dehydrogenase', 'Membrane Potentials', 'Mesencephalon', 'Mice', 'Mice, Inbred Strains', 'M... | 15,328,030 | [['B01.050'], ['A11.251'], ['D27.505.954.427'], ['D27.720.233'], ['G05.200.230'], ['D02.455.426.559.847.181.384.380', 'D04.615.181.384.380'], ['D02.092.211.215.406', 'D02.092.311.342', 'D02.455.426.559.389.657.166.175.342'], ['D27.505.519.625.190.300', 'D27.505.696.577.190.300'], ['D02.455.849.919.277', 'D09.408.782.30... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Depletion of pre beta 1LpA1 and LpA4 particles by mast cell chymase reduces cholesterol efflux from macrophage foam cells induced by plasma. | Exposure of the LpA1-containing particles present in HDL3 and plasma to a minimal degree of proteolysis by the neutral protease chymase from exocytosed rat mast cell granules (granule remnants) leads to a reduction in the high-affinity component of cholesterol efflux from macrophage foam cells. In this study, we demons... | ['Animals', 'Apolipoprotein A-I', 'Apolipoproteins A', 'Cholesterol', 'Cholesterol, HDL', 'Chymases', 'Cytoplasmic Granules', 'Female', 'Foam Cells', 'Humans', 'Lipoprotein(a)', 'Lipoproteins, HDL', 'Lipoproteins, HDL3', 'Male', 'Mast Cells', 'Mice', 'Rats', 'Rats, Wistar', 'Serine Endopeptidases'] | 10,195,937 | [['B01.050'], ['D10.532.091.200.100', 'D12.776.070.400.200.100', 'D12.776.521.120.200.100'], ['D10.532.091.200', 'D12.776.070.400.200', 'D12.776.521.120.200'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['D04.210.500.247.808.197.238', 'D10.532.432.400', 'D10.570.938.208.270', 'D12.776.52... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Risk factors for enamel fluorosis in a nonfluoridated population. | The purpose of this case-control investigation was to investigate the possible association between mild-to-moderate enamel fluorosis and exposure during early childhood to fluoride supplements, fluoride toothpaste, and/or infant formula use in nonfluoridated communities. Analysis was performed on 460 10- to 13-year-old... | ['Adolescent', 'Case-Control Studies', 'Child', 'Connecticut', 'Fluoridation', 'Fluorides', 'Fluorosis, Dental', 'Humans', 'Logistic Models', 'Massachusetts', 'Observer Variation', 'Risk Factors', 'Surveys and Questionnaires', 'Toothpastes'] | 8,610,691 | [['M01.060.057'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['M01.060.406'], ['Z01.107.567.875.550.200'], ['E06.761.382', 'N06.890.235'], ['D01.248.497.158.380', 'D01.303.350.300'], ['C07.793.330'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.525', 'E05.318.74... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
Rapid mixing of sub-microlitre drops by magnetic micro-stirring. | We demonstrate rapid mixing of sub-microlitre droplets (250 nl) using miniaturized magnetic stir bars (400 ìm ? 200 ìm ? 15 ìm). The stir bars are fabricated using laser micromachining and placed on the substrate on which the drops are manipulated. They are activated by an externally applied magnetic field and used in ... | ['Fluorescence Resonance Energy Transfer', 'Magnetics', 'Microfluidic Analytical Techniques', 'Miniaturization', 'Physical Phenomena', 'Thermodynamics'] | 21,842,085 | [['E05.196.712.516.600.676.500', 'G01.154.240.280', 'G02.111.255.280'], ['H01.671.493'], ['E05.588.465'], ['J01.897.520'], ['G01'], ['G01.906']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Delinking Investment in Antibiotic Research and Development from Sales Revenues: The Challenges of Transforming a Promising Idea into Reality. | Kevin Outterson and colleagues outline a model to address access, conservation, and innovation of antibiotics. | ['Anti-Bacterial Agents', 'Commerce', 'Drug Industry', 'Investments', 'Models, Theoretical', 'Pharmaceutical Research'] | 27,299,990 | [['D27.505.954.122.085'], ['J01.219'], ['J01.576.655.750'], ['N03.219.702'], ['E05.599'], ['H01.770.644.145.442']] | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 |
Retinal angiography with real-time speckle variance optical coherence tomography. | This report describes a novel, non-invasive and label-free optical imaging technique, speckle variance optical coherence tomography (svOCT), for visualising blood flow within human retinal capillary networks. This imaging system uses a custom-built swept source OCT system operating at a line rate of 100 kHz. Real-time ... | ['Diabetic Retinopathy', 'Fluorescein Angiography', 'Fundus Oculi', 'Humans', 'Regional Blood Flow', 'Reproducibility of Results', 'Retinal Artery Occlusion', 'Retinal Vein Occlusion', 'Retinal Vessels', 'Time Factors', 'Tomography, Optical Coherence'] | 25,733,527 | [['C11.768.257', 'C14.907.320.382', 'C19.246.099.500.382'], ['E01.370.370.050.350', 'E01.370.380.250'], ['A09.371.729.313'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G09.330.100.780'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['C11.768.400', 'C14.907.137.780'], ['C11.7... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Striking regression of chronic radiotherapy damage in a clinical trial of combined pentoxifylline and tocopherol. | PURPOSE: Radiation-induced fibrosis (RIF) remains the most morbid complication of radiotherapy because of the absence of spontaneous regression and the difficulty of patient management. RIF treatment with combined pentoxifylline (PTX) and tocopherol (Vit E) was prompted by recent advances in cellular and molecular biol... | ['Adult', 'Aged', 'Breast Neoplasms', 'Drug Therapy, Combination', 'Female', 'Head and Neck Neoplasms', 'Humans', 'Male', 'Middle Aged', 'Pentoxifylline', 'Pulmonary Fibrosis', 'Radiation Injuries', 'Radiation-Protective Agents', 'Radiotherapy', 'Treatment Outcome', 'Vitamin E'] | 10,506,631 | [['M01.060.116'], ['M01.060.116.100'], ['C04.588.180', 'C17.800.090.500'], ['E02.319.310'], ['C04.588.443'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['D03.633.100.759.758.824.651.700'], ['C08.381.765'], ['C26.733', 'G01.750.748.500', 'N06.850.460.350.850.500', 'N06.850.810.300.360'], ['D27... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Assessment of the endoscopic retrograde cholangiopancreatography grading system: A prospective study from a tertiary care center. | BACKGROUND/AIMS: The American Society for Gastrointestinal Endoscopy (ASGE) endoscopic retrograde cholangiopancreatography (ERCP) grading system was proposed but has not been fully evaluated with prospective clinical studies. In this study, we aimed to evaluate the effectiveness of the ERCP difficulty grading system fo... | ['Adult', 'Aged', 'Cholangiopancreatography, Endoscopic Retrograde', 'Clinical Competence', 'Female', 'Humans', 'Male', 'Middle Aged', 'Outcome and Process Assessment, Health Care', 'Postoperative Complications', 'Prospective Studies', 'Quality Indicators, Health Care', 'Tertiary Care Centers'] | 26,853,789 | [['M01.060.116'], ['M01.060.116.100'], ['E01.370.350.700.715.200.200', 'E01.370.372.200.200', 'E01.370.372.250.200', 'E01.370.388.250.250.160', 'E04.210.240.160', 'E04.502.250.250.160'], ['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['N04.761.55... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Reduction in duodenal endocrine cells in irritable bowel syndrome is associated with stem cell abnormalities. | AIM: To determine whether the decreased density of duodenal endocrine cells in irritable bowel syndrome (IBS) is associated with abnormalities in stem cell differentiation.METHODS: The study sample comprised 203 patients with IBS (180 females and 23 males with a mean age of 36 years) and a control group of 86 healthy s... | ['Adolescent', 'Adult', 'Aged', 'Basic Helix-Loop-Helix Transcription Factors', 'Biomarkers', 'Biopsy', 'Case-Control Studies', 'Cell Differentiation', 'Duodenum', 'Enteroendocrine Cells', 'Female', 'Gastroscopy', 'Humans', 'Immunohistochemistry', 'Irritable Bowel Syndrome', 'Male', 'Middle Aged', 'Nerve Tissue Protein... | 26,327,765 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['D12.776.260.103', 'D12.776.930.125'], ['D23.101'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Genetic variability in cysteine protease genes of Haemonchus contortus. | To increase the existent genetic variability in cysteine proteases, a polymorphism study was performed in Haemonchus contortus by comparing 2 different strains of the parasite: North American (NA) and Spanish (SP) strains. For this purpose, the polymorphism of 5 previously reported genes (AC-1, AC-3, AC-4, AC-5 and GCP... | ['Alleles', 'Amino Acid Sequence', 'Animals', 'Base Sequence', 'Cysteine Endopeptidases', 'DNA, Helminth', 'Genetic Variation', 'Haemonchus', 'Male', 'Molecular Sequence Data', 'North America', 'Phylogeny', 'Polymerase Chain Reaction', 'Polymorphism, Single Nucleotide', 'Polymorphism, Single-Stranded Conformational', '... | 15,180,323 | [['G05.360.340.024.340.030'], ['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D08.811.277.656.262.500', 'D08.811.277.656.300.200'], ['D13.444.308.315'], ['G05.365'], ['B01.050.500.500.294.400.968.746.410'], ['L01.453.245.667'], ['Z01.107.567'], ['G05... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 |
Serum YKL-40 for monitoring myocardial ischemia after revascularization in patients with stable coronary artery disease. | AIM: The aim was to investigate the inflammatory biomarker YKL-40 as a monitor of myocardial ischemia in patients with coronary artery disease (CAD).METHODS: A total of 311 patients with stable CAD were included. Blood samples were taken at baseline, the day after coronary angiography and/or after percutaneous coronary... | ['Adipokines', 'Adult', 'Aged', 'Aged, 80 and over', 'Biomarkers', 'Case-Control Studies', 'Chitinase-3-Like Protein 1', 'Coronary Artery Disease', 'Disease Progression', 'Female', 'Follow-Up Studies', 'Growth Substances', 'Humans', 'Lectins', 'Male', 'Middle Aged', 'Myocardial Ischemia', 'Myocardial Revascularization'... | 25,343,670 | [['D06.472.699.042', 'D12.644.276.024', 'D12.644.548.011', 'D12.776.467.024', 'D23.529.024'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D23.101'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['D08.811.277.450.207.500', 'D12.776.503.070'], ['C14.280.647.250.260',... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Microvascular decompression for classic trigeminal neuralgia: determination of minimum clinically important difference in pain improvement for patient reported outcomes. | BACKGROUND: Outcomes studies use patient-reported outcome (PRO) measurements to assess treatment effectiveness, but can lack direct clinical meaning. Minimum clinically important difference (MCID) calculation provides a point estimate of the critical threshold needed to achieve clinically relevant treatment effectivene... | ['Diagnostic Self Evaluation', 'Female', 'Humans', 'Male', 'Microvascular Decompression Surgery', 'Middle Aged', 'Pain', 'Pain Measurement', 'Reproducibility of Results', 'Sensitivity and Specificity', 'Treatment Outcome', 'Trigeminal Neuralgia'] | 23,328,688 | [['E01.370.360', 'F01.752.747.792.220'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.188.600', 'E04.525.500'], ['M01.060.116.630'], ['C23.888.592.612', 'F02.830.816.444', 'G11.561.790.444'], ['E01.370.600.550.324'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['E05.318.3... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Redundant roles for Met docking site tyrosines and the Gab1 pleckstrin homology domain in InlB-mediated entry of Listeria monocytogenes. | The bacterial pathogen Listeria monocytogenes causes food-borne illnesses leading to gastroenteritis, meningitis, or abortion. Listeria induces its internalization into some mammalian cells through interaction of the bacterial surface protein InlB with host Met receptor tyrosine kinase. Binding of InlB leads to phospho... | ['Adaptor Proteins, Signal Transducing', 'Bacterial Proteins', 'Binding Sites', 'Blood Proteins', 'Humans', 'Listeria monocytogenes', 'Membrane Proteins', 'Phosphatidylinositol 3-Kinases', 'Phosphoproteins', 'Phosphorylation', 'Protein-Serine-Threonine Kinases', 'Proto-Oncogene Proteins', 'Proto-Oncogene Proteins c-akt... | 15,784,547 | [['D12.644.360.024', 'D12.776.157.057', 'D12.776.476.024'], ['D12.776.097'], ['G02.111.570.120'], ['D12.776.124'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B03.353.500.500.500', 'B03.510.100.500.500', 'B03.510.460.400.410.485.500'], ['D12.776.543'], ['D08.811.913.696.620.500'], ['D12.776.744'], ['G02.111.665'... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Suppression of nodulation gene expression in bacteroids of Rhizobium leguminosarum biovar viciae. | The expression of nod genes of Rhizobium leguminosarum bv. viciae in nodules of Pisum sativum was investigated at both the translational and transcriptional levels. By using immunoblots, it was found that the levels of NodA, NodI, NodE, and NodO proteins were reduced at least 14-fold in bacteriods compared with culture... | ['Acyltransferases', 'Bacterial Proteins', 'Blotting, Northern', 'Crosses, Genetic', 'Escherichia coli', 'Fabaceae', 'Genes, Bacterial', 'Membrane Proteins', 'Nitrogen Fixation', 'Nucleic Acid Hybridization', 'Plants, Medicinal', 'Plasmids', 'Promoter Regions, Genetic', 'RNA, Bacterial', 'Restriction Mapping', 'Rhizobi... | 1,712,355 | [['D08.811.913.050'], ['D12.776.097'], ['E05.196.401.095', 'E05.301.300.074', 'E05.601.100'], ['E05.393.281'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['B01.650.940.800.575.912.250.401'], ['G05.360.340.024.340.364.249', 'G05.360.340.358.024.249', 'G05.360.340.358.207.249'], ['D12.776.543'], ['G02.111.07... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The use of highly expressed FTH1 as carrier protein for cytosolic targeting in Hansenula polymorpha. | The iron storage protein ferritin is a member of the non-heme iron protein family. It can store and release iron, therefore it prevents the cell from damage caused by iron-dioxygen reactions as well as it provides iron for biological processing. To study whether the human ferritin heavy chain (FTH1) can be expressed in... | ['Cloning, Molecular', 'Cytosol', 'Fermentation', 'Ferritins', 'Humans', 'Iron', 'Oxidoreductases', 'Parathyroid Hormone', 'Pichia', 'Protein Engineering', 'Recombinant Fusion Proteins', 'Solubility'] | 22,212,821 | [['E05.393.220'], ['A11.284.430.214.200', 'A11.284.430.429.200', 'A11.284.835.450.200'], ['G02.111.158.249', 'G03.191.249'], ['D12.776.157.427.249', 'D12.776.556.579.249'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.268.556.412', 'D01.268.956.287', 'D01.552.544.412'], ['D08.811.682'], ['D06.472.699.590', 'D... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Neuronal intestinal dysplasia--clinical and histochemical findings and its association with Hirschsprung's disease. | Neuronal intestinal dysplasia (NID) is a disturbance of the innervation of the gut. Its symptoms resemble the ones seen in Hirschsprung's Disease. Contrary to aganglionosis, however, there is hyperplasia of the ganglia. Our study revealed isolated NID (4/49 cases) to be eight times rarer than aganglionosis (33/49 patie... | ['Child, Preschool', 'Diseases in Twins', 'Female', 'Follow-Up Studies', 'Hirschsprung Disease', 'Humans', 'Hyperplasia', 'Infant', 'Infant, Newborn', 'Infant, Premature, Diseases', 'Intestinal Mucosa', 'Intestinal Obstruction', 'Intestines', 'Male', 'Muscle, Smooth', 'Myenteric Plexus', 'Parasympathetic Nervous System... | 3,788,295 | [['M01.060.406.448'], ['C23.550.291.750'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['C06.198.439', 'C06.405.469.158.701.439', 'C16.131.314.439'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.444'], ['M01.060.703'], ['M01.060.703.520'], ['C16.614.521'], ['... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Dynamic control on the rate of the reduction of the b type cytochromes in submitochondrial particles. | 1. In the presence of antimycin and KCN the reduction of cytochrome b in phosphorylating submitochondrial particles followed a biphasic first-order kinetics. The transition from the first, rapid phase to the second, slow phase occurred while the reduction of chtochromes c + c1 and a through or around the antimycin bloc... | ['Animals', 'Antimycin A', 'Cattle', 'Cyanides', 'Cytochromes', 'Enzyme Activation', 'Kinetics', 'Mitochondria, Muscle', 'Myocardium', 'NAD', 'Oxidation-Reduction', 'Rats', 'Species Specificity', 'Spectrophotometry', 'Succinates', 'Temperature', 'Time Factors'] | 170,082 | [['B01.050'], ['D02.540.576.500.750'], ['B01.050.150.900.649.313.500.380.271'], ['D01.248.497.158.291', 'D01.625.400.100'], ['D08.244', 'D12.776.422.220'], ['G02.111.263', 'G03.328'], ['G01.374.661', 'G02.111.490'], ['A11.284.430.214.190.875.564.627', 'A11.284.835.626.627'], ['A02.633.580', 'A07.541.704', 'A10.690.552.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[Morphology of collagen matrices for tissue engineering (biocompatibility, biodegradation, tissue response)]. | OBJECTIVE: to perform a comparative morphological study of biocompatibility, biodegradation, and tissue response to implantation of collagen matrices (scaffolds) for tissue engineering in urology and other areas of medicine.MATERIAL AND METHODS: Nine matrix types, such as porous materials reconstructed from collagen so... | ['Absorbable Implants', 'Animals', 'Biocompatible Materials', 'Cattle', 'Collagen', 'Fishes', 'Horses', 'Humans', 'Prostheses and Implants', 'Rats', 'Regenerative Medicine', 'Swine', 'Tissue Engineering', 'Tissue Scaffolds'] | 26,841,647 | [['E07.695.025'], ['B01.050'], ['D25.130', 'D27.720.102.130', 'J01.637.051.130'], ['B01.050.150.900.649.313.500.380.271'], ['D05.750.078.280', 'D12.776.860.300.250'], ['B01.050.150.900.493'], ['B01.050.150.900.649.313.984.235.472'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E07.695'], ['B01.050.150.900.649.313... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Expression of classic cadherins and delta-protocadherins in the developing ferret retina. | BACKGROUND: Cadherins are a superfamily of calcium-dependent adhesion molecules that play multiple roles in morphogenesis, including proliferation, migration, differentiation and cell-cell recognition. The subgroups of classic cadherins and delta-protocadherins are involved in processes of neural development, such as n... | ['Animals', 'Cadherins', 'Ferrets', 'In Situ Hybridization', 'Neurons', 'Retina', 'Retinal Ganglion Cells'] | 20,028,529 | [['B01.050'], ['D12.776.395.550.200.200', 'D12.776.543.550.200.200', 'D23.050.301.350.200'], ['B01.050.150.900.649.313.750.250.575.350'], ['E01.370.225.500.620.670.325', 'E01.370.225.750.600.670.325', 'E05.200.500.620.670.325', 'E05.200.750.600.670.325', 'E05.393.661.475'], ['A08.675', 'A11.671'], ['A09.371.729'], ['A0... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Microcirculatory disorders caused by gunshot wounds of the small intestine (experimental study)]. | The mirocirculatory dynamics in intestinal wall at different distances from the wound canal was established in experimental dogs using the stimulation of jejunal high-energetic gunshot injury. The radial spectrum of microcirculatory changes is characterized by the following parameters: the decreased arterio- and arteri... | ['Animals', 'Dogs', 'Lymphatic System', 'Microcirculation', 'Vascular Diseases', 'Wounds, Gunshot'] | 12,722,509 | [['B01.050'], ['B01.050.150.900.649.313.750.250.216.200'], ['A15.382.520'], ['G09.330.100.645'], ['C14.907'], ['C26.986.900']] | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Long term cassette EEG monitoring of childhood seizures. | We studied the clinical efficacy of 4-channel cassette recording of the EEG for 105 children being evaluated for possible seizures or further clarification of a known seizure disorder. Compared to the conventional EEG, 24 hour cassette EEG (C-EEG) studies yielded new diagnostic electroclinical information for 21 percen... | ['Adolescent', 'Adult', 'Cerebral Cortex', 'Child', 'Child, Preschool', 'Electroencephalography', 'Epilepsy', 'Evoked Potentials', 'Humans', 'Infant', 'Infant, Newborn', 'Monitoring, Physiologic', 'Signal Processing, Computer-Assisted', 'Spasms, Infantile', 'Tape Recording'] | 3,880,388 | [['M01.060.057'], ['M01.060.116'], ['A08.186.211.200.885.287.500'], ['M01.060.406'], ['M01.060.406.448'], ['E01.370.376.300', 'E01.370.405.245'], ['C10.228.140.490'], ['G07.265.216.500', 'G11.561.200.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['E01.370.520'], ['L01.224... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Information Science [L]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 |
A Simplified Geboes Score for Ulcerative Colitis. | Background and Aims: The original Geboes Score [OGS] is the most commonly used histological score in ulcerative colitis [UC], but rather complicated to use in daily clinical practice. The aim of this study was to develop a Simplified Geboes Score [SGS] and to compare it with the OGS in patients newly diagnosed with UC.... | ['Adult', 'Biopsy', 'Colitis, Ulcerative', 'Colon', 'Colonoscopy', 'Female', 'Humans', 'Intestinal Mucosa', 'Male', 'Middle Aged', 'Neutrophils', 'Observer Variation', 'Retrospective Studies', 'Severity of Illness Index', 'Young Adult'] | 27,571,771 | [['M01.060.116'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['C06.405.205.265.231', 'C06.405.205.731.249', 'C06.405.469.158.188.231', 'C06.405.469.432.249'], ['A03.556.124.526.356', 'A03.556.249.249.356'], ['E01.370.372... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Awareness of cancer risk factors among patients and attendants presenting to a tertiary care hospital in Karachi, Pakistan. | OBJECTIVE: To determine awareness of cancer risk factors in the patients and attendants of Out-patient Clinics at a University Hospital in Karachi, Pakistan.METHODS: A cross-sectional survey was conducted on 315 respondents reporting to a tertiary care hospital in Karachi, Pakistan, to assess their level of awareness r... | ['Adolescent', 'Adult', 'Aged', 'Awareness', 'Cross-Sectional Studies', 'Early Diagnosis', 'Female', 'Hospitals, University', 'Humans', 'Male', 'Mass Screening', 'Middle Aged', 'Neoplasms', 'Outpatient Clinics, Hospital', 'Pakistan', 'Patient Education as Topic', 'Patients', 'Risk Factors', 'Surveys and Questionnaires'... | 18,998,318 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['F02.463.188.150'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['E01.390'], ['N02.278.020.300.310', 'N02.278.421.639.725'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.500', 'E05.318.308.980.438.580', 'N02.421.72... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Sequential Organ Failure Assessment predicts the outcome of SCT recipients admitted to intensive care unit. | We analyzed all patients undergoing allogeneic stem cell transplantation (ASCT) and transferred to the intensive care unit (ICU) from January 1995 to December 2005. During this period, 661 patients underwent ASCT at our center. A total of 91 patients were admitted to the ICU. Median time from ASCT to ICU admission was ... | ['APACHE', 'Adolescent', 'Adult', 'Aged', 'Child', 'Child, Preschool', 'Female', 'Humans', 'Infant', 'Intensive Care Units', 'Male', 'Middle Aged', 'Multiple Organ Failure', 'Patient Transfer', 'Severity of Illness Index', 'Stem Cell Transplantation', 'Survival Analysis', 'Transplantation, Homologous', 'Young Adult'] | 19,718,056 | [['E05.318.308.980.438.475.365', 'E05.318.308.980.438.475.456.500.250', 'N05.715.360.300.800.438.375.364.500.250', 'N06.850.520.308.980.438.475.364.500.250'], ['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Named Groups [M]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Selective inhibition of protein kinases blocks the formation of a new axis, the beginning of budding, in Hydra. | In Hydra, head regeneration and bud formation appear to be very similar processes. The fact that there are genes whose expression is specific for one of the two processes suggests that they do not have identical molecular bases. We analyzed the signal transduction pathways regulating bud development using inhibitors of... | ['Animals', 'Enzyme Inhibitors', 'Hydra', 'In Situ Hybridization', 'Mitogen-Activated Protein Kinase 1', 'Mitogen-Activated Protein Kinase 3', 'Mitogen-Activated Protein Kinases', 'Phosphatidylinositol 3-Kinases', 'Protein Kinase C', 'Protein Kinase Inhibitors', 'Signal Transduction', 'Time Factors'] | 12,464,429 | [['B01.050'], ['D27.505.519.389'], ['B01.050.500.308.485.400'], ['E01.370.225.500.620.670.325', 'E01.370.225.750.600.670.325', 'E05.200.500.620.670.325', 'E05.200.750.600.670.325', 'E05.393.661.475'], ['D08.811.913.696.620.682.700.567.249.500', 'D12.644.360.450.169.500', 'D12.776.476.450.169.500'], ['D08.811.913.696.62... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Compared biology and behavior of Tetranychus urticae Koch (Acari: Tetranychidae) and Phytoseiulus macropilis (Banks) (Acari: Phytoseiidae) on Bollgard and non-transgenic isoline cotton]. | The two spotted spider mite, Tetranychus urticae Koch, is a nontarget herbivore of Bt-cotton, but acquires and accumulates higher levels of Cry toxin than that expressed by transgenic plants. This work investigated the development and reproduction of T. urticae and of the predator Phytoseiulus macropilis Banks, during ... | ['Acari', 'Animals', 'Behavior, Animal', 'Gossypium', 'Plants, Genetically Modified', 'Tetranychidae'] | 20,676,505 | [['B01.050.500.131.166.132'], ['B01.050'], ['F01.145.113'], ['B01.650.940.800.575.912.250.859.821.500.244'], ['B01.650.520', 'B05.620.600'], ['B01.050.500.131.166.132.419.850']] | ['Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A clinicopathological study of orbito-ocular diseases in Ibadan between 1991-1999. | To describe the pattern of ocular diseases seen during the study period. Retrospective review of surgical pathology and cytology records from January 1991 to December 1999. Reference was also made to case notes where necessary. A total of 225 orbital and ocular surgical pathology specimens were reviewed. One hundred an... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Child', 'Child, Preschool', 'Eye Diseases', 'Female', 'Humans', 'Infant', 'Infant, Newborn', 'Male', 'Middle Aged', 'Nigeria', 'Orbital Diseases', 'Retrospective Studies'] | 15,032,469 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['M01.060.406'], ['M01.060.406.448'], ['C11'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['M01.060.116.630'], ['Z01.058.290.190.565'], ['C11.675'], ['E05.318.372.500.500.500', 'E05.318.372.500.7... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Global temporal changes in the proportion of children with advanced disease at the start of combination antiretroviral therapy in an era of changing criteria for treatment initiation. | INTRODUCTION: The CD4 cell count and percent at initiation of combination antiretroviral therapy (cART) are measures of advanced HIV disease and thus are important indicators of programme performance for children living with HIV. In particular, World Health Organization (WHO) 2017 guidelines on advanced HIV disease not... | ['Adolescent', 'Adult', 'Anti-HIV Agents', 'CD4 Lymphocyte Count', 'Child', 'Child, Preschool', 'Cohort Studies', 'Databases, Factual', 'Drug Administration Schedule', 'Drug Therapy, Combination', 'Female', 'Follow-Up Studies', 'Global Health', 'HIV Infections', 'Humans', 'Income', 'Male', 'Poverty', 'Prospective Studi... | 30,614,622 | [['M01.060.057'], ['M01.060.116'], ['D27.505.954.122.388.077.088'], ['E01.370.225.500.195.107.595.500.150', 'E01.370.225.625.107.595.500.150', 'E05.200.500.195.107.595.500.150', 'E05.200.625.107.595.500.150', 'E05.242.195.107.595.500.150', 'G04.140.107.595.500.150', 'G09.188.105.595.500.150'], ['M01.060.406'], ['M01.06... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Information Science [L]', 'Disciplines and Occupations [H]', 'Diseases [C]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenome... | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 |
Preparation of dendrimer SAM on Au substrate and adsorption/desorption of poly-L-glutamate on the SAM. | A self-assembled monolayer (SAM) of a dendrimer has been fabricated by covalent bonding of amine-terminated dendrimers to 3-mercaptopropionic acid SAM on an Au substrate, where an amide bond was formed between the amine and the carboxylic acid using amide-coupling reagents. Each reaction step was inspected by transmiss... | ['Adsorption', 'Amides', 'Biocompatible Materials', 'Carboxylic Acids', 'Electrochemistry', 'Glutamates', 'Gold', 'Hydrogen Bonding', 'Hydrogen-Ion Concentration', 'Membranes, Artificial', 'Microscopy, Electron, Transmission', 'Polyglutamic Acid', 'Solvents', 'Spectrophotometry', 'Spectroscopy, Fourier Transform Infrar... | 16,108,429 | [['G01.030', 'G02.020'], ['D02.065'], ['D25.130', 'D27.720.102.130', 'J01.637.051.130'], ['D02.241'], ['H01.181.529.307'], ['D12.125.067.625', 'D12.125.119.409'], ['D01.268.556.322', 'D01.268.956.186', 'D01.552.544.322'], ['G02.282'], ['G02.300'], ['D25.479', 'J01.637.051.479', 'J01.637.087.500'], ['E01.370.350.515.402... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Cementless bipolar hemiarthroplasty using a rectangular cross-section stem for unstable intertrochanteric fractures. | The purpose of this study was to compare the clinical and radiographic results for elderly patients sustaining unstable intertrochanteric fractures treated with an uncemented bipolar hemiarthroplasty using a double-tapered, rectangular cross-section stem. Thirty-seven patients (21 females, 16 males; mean age 73.5 years... | ['Activities of Daily Living', 'Aged', 'Aged, 80 and over', 'Female', 'Follow-Up Studies', 'Fracture Fixation, Internal', 'Hemiarthroplasty', 'Hip Fractures', 'Hip Prosthesis', 'Humans', 'Male', 'Prosthesis Design', 'Radiography', 'Retrospective Studies', 'Treatment Outcome'] | 23,760,747 | [['E02.760.169.063.500.067', 'E02.831.067', 'I03.050', 'N02.421.784.110'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['E04.555.300.300'], ['E04.555.110.110.482', 'E04.650.110.482', 'E04.680.101.110.482'], ['C26.404.061.425', ... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Named Groups [M]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Treatment of Amaranthus cruentus with chemical and biological inducers of resistance has contrasting effects on fitness and protection against compatible Gram positive and Gram negative bacterial pathogens. | Amaranthus cruentus (Ac) plants were treated with the synthetic systemic acquired resistance (SAR) inducer benzothiadiazole (BTH), methyl jasmonate (MeJA) and the incompatible pathogen, Pseudomonas syringae pv. syringae (Pss), under greenhouse conditions. The treatments induced a set of marker genes in the absence of p... | ['Acetates', 'Amaranthus', 'Cyclopentanes', 'Gene Expression Regulation, Plant', 'Gram-Negative Bacteria', 'Gram-Positive Bacteria', 'Oxylipins', 'Plant Diseases', 'Pseudomonas syringae', 'Thiadiazoles'] | 24,913,050 | [['D02.241.081.018', 'D10.251.400.045'], ['B01.650.940.800.575.912.250.198.500.100.130'], ['D02.455.426.392.368.450'], ['G05.308.375'], ['B03.440'], ['B03.510'], ['D10.251.355.645'], ['G15.610'], ['B03.440.400.425.625.625.770', 'B03.660.250.580.590.770'], ['D02.886.675.867', 'D03.383.129.708.867']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A structural model of perfusion and oxygenation in low-flow states. | BACKGROUND: Recent investigations underscore the critical importance of ventilation strategies on resuscitation outcomes. In low perfusion states, such as cardiac arrest and traumatic shock, the rise in intrathoracic pressure that accompanies positive-pressure ventilation can significantly impede venous return and lead... | ['Lung', 'Lung Volume Measurements', 'Models, Biological', 'Models, Structural', 'Oxygen', 'Pressure'] | 21,724,316 | [['A04.411'], ['E01.370.386.700.485'], ['E05.599.395'], ['J01.897.280.500.545', 'L01.178.820.090.545'], ['D01.268.185.550', 'D01.362.670'], ['G01.374.715']] | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Determination of water-extractable nonstructural carbohydrates, including inulin, in grass samples with high-performance anion exchange chromatography and pulsed amperometric detection. | The exact and reliable determination of carbohydrates in plant samples of different origin is of great importance with respect to plant physiology. Additionally, the identification and quantification of carbohydrates are necessary for the evaluation of the impact of these compounds on the biogeochemistry of carbon. To ... | ['Carbohydrates', 'Chromatography, High Pressure Liquid', 'Chromatography, Ion Exchange', 'Inulin', 'Lolium', 'Poaceae', 'Reproducibility of Results'] | 18,698,790 | [['D09'], ['E05.196.181.400.300'], ['E05.196.181.400.383'], ['D05.750.078.562.855.750', 'D09.301.915.750', 'D09.698.350.500', 'D09.698.365.855.750'], ['B01.650.940.800.575.912.250.822.500'], ['B01.650.940.800.575.912.250.822'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Adverse childhood events are associated with obesity and disordered eating: results from a U.S. population-based survey of young adults. | The authors investigated the relationship between childhood abuse and obesity in young adulthood (M age = 22) in a large, U.S. representative sample (N = 15,197). Controlling for demographics and depression, men with a history of childhood sexual abuse were at increased risk of overweight and obesity. No association be... | ['Adolescent', 'Child', 'Child Abuse', 'Cross-Sectional Studies', 'Feeding and Eating Disorders', 'Female', 'Health Surveys', 'Humans', 'Male', 'Obesity', 'Odds Ratio', 'Risk Factors', 'United States', 'Young Adult'] | 19,588,510 | [['M01.060.057'], ['M01.060.406'], ['I01.198.240.856.350.250', 'I01.880.735.900.350.250'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['F03.400'], ['E05.318.308.980.438', 'N05.715.360.300.800.438', 'N06.850.520.308.980.438'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C18.654... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Parametric study of the biopotential equation for breast tumour identification using ANOVA and Taguchi method. | Extensive literatures have shown significant trend of progressive electrical changes according to the proliferative characteristics of breast epithelial cells. Physiologists also further postulated that malignant transformation resulted from sustained depolarization and a failure of the cell to repolarize after cell di... | ['Analysis of Variance', 'Breast Neoplasms', 'Electric Capacitance', 'Female', 'Humans', 'Models, Biological', 'Models, Statistical'] | 16,929,931 | [['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['C04.588.180', 'C17.800.090.500'], ['G01.358.500.249.270'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.395'], ['E05.318.740.500', 'E05.599.835', 'N05.715.360.750.530', 'N06.850.520.830.500']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Influence of age on effects induced by intermittent ethanol treatment on the ethanol drinking pattern and related neurochemical changes in the rat. | Male rats were treated with one ethanol (2.0 g/kg i.p.) or saline injections once a week for 50 weeks. During this treatment period the rats had in addition access to ethanol (10% in drinking fluid) as a choice against water for 24 h prior to the injection. During the following evaluation period, animals had a continuo... | ['Age Factors', 'Alcohol Drinking', 'Alcoholism', 'Animals', 'Brain', 'Dose-Response Relationship, Drug', 'Drug Administration Schedule', 'Ethanol', 'Male', 'Neurotransmitter Agents', 'Rats', 'Rats, Inbred Strains', 'Receptors, Neurotransmitter'] | 2,906,864 | [['N05.715.350.075', 'N06.850.490.250'], ['F01.145.317.269'], ['C25.775.100.250', 'F03.900.100.350'], ['B01.050'], ['A08.186.211'], ['G07.690.773.875', 'G07.690.936.500'], ['E02.319.283'], ['D02.033.375'], ['D27.505.519.625', 'D27.505.696.577'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760', '... | ['Health Care [N]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Microprocessor in controlled transdermal drug delivery of anti-cancer drugs. | Microprocessor controlled transdermal delivery of anticancer drugs 5-Fluorouracil (5-FU) and 6-Mercaptopurine (6-MP) was developed and in vitro evaluation was done. Drugs were loaded based on the pharmacokinetics parameters. In vitro diffusion studies were carried at different current density (0.0, 0.1, 0.22, 0.50 mA/c... | ['Administration, Cutaneous', 'Antineoplastic Agents', 'Cadaver', 'Delayed-Action Preparations', 'Diffusion', 'Drug Delivery Systems', 'Electric Impedance', 'Fluorouracil', 'Humans', 'Mercaptopurine', 'Microcomputers', 'Skin', 'Skin Absorption'] | 18,592,348 | [['E02.319.267.120.060'], ['D27.505.954.248'], ['C23.550.260.224'], ['D26.255.210', 'E02.319.300.253'], ['G01.202', 'G02.196'], ['E02.319.300'], ['G01.358.500.249.277.350'], ['D03.383.742.698.875.404'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.886.489.534', 'D03.633.100.759.570'], ['L01.224.230.260.550'],... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Information Science [L]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Synthesis of bis(imidazole) metal complexes and their use in rapid NO detection and quantification devices. | To explore the release of nitrogen oxide gases from reaction solutions, we developed a series of colorimetric sensors based on the cis-nitrogen-donating ligand bis(1-methylimidazol-2-yl)phenylmethoxymethane (BIPhMe). The complexes M(BIPhMe)X2, where M is Fe(2+) or Co(2+) and X is Cl(-), Br(-), or I(-), were prepared an... | ['Colorimetry', 'Coordination Complexes', 'Crystallography, X-Ray', 'Equipment Design', 'Gases', 'Imidazoles', 'Ligands', 'Models, Molecular', 'Nitric Oxide', 'Solutions'] | 25,419,858 | [['E05.196.922.250'], ['D01.234', 'D02.257'], ['E05.196.309.742.225'], ['E05.320'], ['D01.362'], ['D03.383.129.308'], ['D27.720.470.480'], ['E05.599.595'], ['D01.339.387', 'D01.625.550.500', 'D01.625.700.500', 'D01.650.550.587.600'], ['D26.776']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
GH, IGF-I, IGFBP-3 and IGFBP-2 in cerebrospinal fluid of infants, during puberty and in adults. | During diagnostic lumbar punctions cerbrospinal fluid (CSF) was collected for the determination of GH, IGF-I, IGFBP-3 and IGFBP-2. The patients were 0.3 to 68 years od and suffered from viral infections, leukemias, M. Hodgkin or multiple sclerosis. Only CSF samples without any pathological alterations were analysed. In... | ['Adolescent', 'Adult', 'Age Factors', 'Aged', 'Albumins', 'Child', 'Child, Preschool', 'Female', 'Growth Hormone', 'Humans', 'Infant', 'Insulin-Like Growth Factor Binding Protein 2', 'Insulin-Like Growth Factor Binding Protein 3', 'Insulin-Like Growth Factor I', 'Male', 'Middle Aged', 'Puberty'] | 9,710,360 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['D12.776.034'], ['M01.060.406'], ['M01.060.406.448'], ['D06.472.699.631.525.425', 'D12.644.548.691.525.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['D12.776.157.420.260'], ['D12.776.157.420.270'... | ['Named Groups [M]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Bone marrow stromal cells transduced with a thrombopoietin, interleukin-6, and interleukin-11 syncretic gene induce cord mononuclear cells to generate platelets in vitro. | BACKGROUND: The induction of hematopoietic stem cells to produce mass numbers of platelets (PLTs) in vitro is an effective method to address a lack of PLTs and PLT transfusion resistance in the clinic. However, the design of a low-cost and sustainable culture system is currently problematic.STUDY DESIGN AND METHODS: He... | ['Adenoviridae', 'Base Sequence', 'Blood Platelets', 'Cells, Cultured', 'Coculture Techniques', 'Enzyme-Linked Immunosorbent Assay', 'Fetal Blood', 'Flow Cytometry', 'Foot-and-Mouth Disease Virus', 'Genes, Synthetic', 'Genetic Vectors', 'Humans', 'Interleukin-11', 'Interleukin-6', 'Leukocytes, Mononuclear', 'Molecular ... | 25,251,668 | [['B04.280.030'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A11.118.188', 'A15.145.229.188'], ['A11.251'], ['E05.481.500.374'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['A12.207.152.200', 'A15.145.300', 'A16.378.200'], ['E01... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Accuracy of visual inspection with acetic acid in detecting high-grade cervical intraepithelial neoplasia in pre- and post-menopausal Thai women with minor cervical cytological abnormalities. | PURPOSE: To determine the accuracy of visual inspection with acetic acid (VIA) in detecting high-grade cervical intraepithelial neoplasia (CIN) in pre- and post-menopausal women with atypical squamous cells of undetermined significance (ASC-US) and low grade squamous intraepithelial lesion (LSIL) Papanicolaou (Pap) sme... | ['Acetic Acid', 'Adult', 'Aged', 'Atypical Squamous Cells of the Cervix', 'Cervical Intraepithelial Neoplasia', 'DNA, Viral', 'Female', 'Follow-Up Studies', 'Humans', 'Menopause', 'Middle Aged', 'Neoplasm Grading', 'Neoplasm Staging', 'Neoplasms, Squamous Cell', 'Papanicolaou Test', 'Papillomaviridae', 'Papillomavirus ... | 25,824,759 | [['D02.241.081.018.165', 'D10.251.400.045.500'], ['M01.060.116'], ['M01.060.116.100'], ['A11.436.123', 'C04.834.818.249', 'C13.351.500.852.593.074.249', 'C23.149.500'], ['C04.557.470.200.240.250'], ['D13.444.308.568'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
ADP-Induced Ca2+ | Nucleotides released during heart injury affect myocardium electrophysiology and remodeling through P2 purinoceptors activation in cardiac myofibroblasts. ATP and UTP endorse [Ca2+ ]i accumulation and growth of DDR-2/á-SMA-expressing myofibroblasts from adult rat ventricles via P2Y4 and P2Y2 receptors activation, respe... | ['Adenosine Diphosphate', 'Aging', 'Animals', 'Calcium', 'Calcium Signaling', 'Cell Proliferation', 'Cells, Cultured', 'Collagen Type I', 'Enzyme Activation', 'Female', 'Heart Ventricles', 'Hydrophobic and Hydrophilic Interactions', 'Ion Channel Gating', 'Male', 'Membrane Microdomains', 'Myofibroblasts', 'Protein Kinas... | 27,755,650 | [['D03.633.100.759.646.138.124', 'D13.695.667.138.124', 'D13.695.827.068.124'], ['G07.345.124'], ['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['G02.111.820.800.100', 'G03.143.500.100', 'G04.835.800.100'], ['G04.161.750', 'G07.345.249.410.750'], ['A11.251'], ['D05.750.078.280.300.100', 'D12.776.86... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Expression of Bradyrhizobium japonicum nodulation gene in Rhizobium fredii nod mutants. | The B. japonicum USDA 110 pLAFR1 gene library was transferred to Tn5-induced Rhizobium fredii USDA 191-4 Nod- mutants with helper plasmid pRK2013. SmR TcR transconjugants occurred with a frequency of 5 x 10(-4). The transconjugants were purified and used to inoculate germinated soybean seeds. Seven nodules were obtaine... | ['Blotting, Southern', 'Cloning, Molecular', 'Conjugation, Genetic', 'Escherichia coli', 'Gene Expression', 'Genes, Bacterial', 'Mutation', 'Nitrogen Fixation', 'Plasmids', 'Restriction Mapping', 'Rhizobiaceae', 'Rhizobium'] | 2,491,321 | [['E05.196.401.114', 'E05.301.300.087', 'E05.601.150'], ['E05.393.220'], ['G05.728.200'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['G05.297'], ['G05.360.340.024.340.364.249', 'G05.360.340.358.024.249', 'G05.360.340.358.207.249'], ['G05.365.590'], ['G02.111.071.630', 'G02.111.587.750', 'G02.607.560.750',... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Factors associated with delayed hepatitis B viral suppression on tenofovir among patients coinfected with HBV-HIV in the CNICS cohort. | BACKGROUND: Despite widespread use in HIV and hepatitis B virus (HBV) infection, the effectiveness of tenofovir (TDF) has not been studied extensively outside of small cohorts of coinfected patients with HBV-HIV. We examined the effect of prior lamivudine (3TC) treatment and other factors on HBV DNA suppression with TD... | ['Adenine', 'Adult', 'Antiviral Agents', 'DNA, Viral', 'Female', 'HIV Infections', 'Hepatitis B virus', 'Hepatitis B, Chronic', 'Humans', 'Male', 'Middle Aged', 'Organophosphonates', 'Tenofovir', 'Time Factors', 'Treatment Outcome', 'Viral Load'] | 24,500,175 | [['D03.633.100.759.138'], ['M01.060.116'], ['D27.505.954.122.388'], ['D13.444.308.568'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['B04.280.375.650.425', 'B04.450.390.650.425'], ['C01.221.250.500.100', 'C01.925.256.430.400.100', 'C01.925... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Effects of cilomilast on dendritic cell function in contact sensitivity and dendritic cell migration through skin. | The phosphodiesterase 4 inhibitor cilomilast demonstrated strong inhibitory effects in a model of allergic contact dermatitis. In this study, we examined whether this inhibitory effect is at least partly due to modulation of dendritic cell function. Bone marrow-derived dendritic cells were pulsed with the sensitizer to... | ['Animals', 'Bronchodilator Agents', 'Carboxylic Acids', 'Cell Movement', 'Cyclohexanecarboxylic Acids', 'Dendritic Cells', 'Dermatitis, Allergic Contact', 'Female', 'Mice', 'Mice, Inbred BALB C', 'Nitriles', 'Skin'] | 14,642,795 | [['B01.050'], ['D27.505.696.663.050.110', 'D27.505.954.796.050.100'], ['D02.241'], ['G04.198', 'G07.568.500.180'], ['D02.241.223.268', 'D02.455.426.392.368.367.218'], ['A11.066.270', 'A11.436.270', 'A15.382.066.270', 'A15.382.670.260'], ['C17.800.174.255.100', 'C17.800.815.255.100', 'C20.543.418.150'], ['B01.050.150.90... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The development of a multiplayer game for education of hospital management. | This paper designed and prototyped a networked hospital management serious game for education, and evaluated the prototype. A player, the president of each hospital, makes management decisions under various clinical indicators, and the decision affects condition of the other hospitals as well as of his/her own. The int... | ['Computer-Assisted Instruction', 'Game Theory', 'Hospital Administration', 'Models, Organizational', 'Software', 'Software Design', 'User-Computer Interface', 'Video Games'] | 23,920,986 | [['I02.903.771.500.208'], ['G17.388'], ['H02.309', 'N02.278.216.500', 'N04.452.442.452'], ['E05.599.670', 'N04.452.534'], ['L01.224.900'], ['L01.224.900.820'], ['L01.224.900.910'], ['I03.450.642.693.930', 'L01.224.900.930']] | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 |
Identification of motoneurons and interneurons in the spinal network for escapes initiated by the mauthner cell in goldfish. | We used intracellular recording and staining techniques to study the spinal circuitry of the escape behavior (C-start) initiated by the Mauthner axon (M-axon) in goldfish. Simultaneous intracellular recordings from one or both M-axons and a spinal neuron, followed by HRP labeling of the spinal cell, show that each M-ax... | ['Animals', 'Axons', 'Cell Communication', 'Efferent Pathways', 'Electrophysiology', 'Escape Reaction', 'Horseradish Peroxidase', 'Interneurons', 'Motor Neurons', 'Neural Pathways', 'Spinal Cord'] | 3,183,720 | [['B01.050'], ['A08.675.542.145', 'A11.284.180.075', 'A11.671.137', 'A11.671.501.145'], ['G04.085'], ['A08.612.380'], ['H01.158.344.528', 'H01.158.782.236'], ['F01.145.113.780.688', 'F01.145.367', 'F01.145.875.439.500.688', 'G07.568.500.590.688', 'G11.427.410.568.850.688'], ['D08.811.682.732.512'], ['A08.675.358', 'A11... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Estimation of velocity vectors in synthetic aperture ultrasound imaging. | A method for determining both velocity magnitude and angle in a synthetic aperture ultrasound system is described. The approach uses directional beamforming along the flow direction and cross correlation to determine velocity magnitude. The angle of the flow is determined from the maximum normalized correlation calcula... | ['Adult', 'Algorithms', 'Blood Flow Velocity', 'Carotid Artery, Common', 'Echocardiography', 'Humans', 'Image Enhancement', 'Image Interpretation, Computer-Assisted', 'Male', 'Phantoms, Imaging', 'Reproducibility of Results', 'Rheology', 'Sensitivity and Specificity'] | 17,167,998 | [['M01.060.116'], ['G17.035', 'L01.224.050'], ['E01.370.370.130', 'G09.330.380.630.080'], ['A07.015.114.186.200'], ['E01.370.350.130.750', 'E01.370.350.850.220', 'E01.370.370.380.220'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.600.350', 'L01.224.308.380'], ['E01.158.600', 'E01.370.350.350', 'L01.3... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Health Care [N]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 |
Acute and chronic cardioprotection by the enkephalin analogue, Eribis peptide 94, is mediated via activation of nitric oxide synthase and adenosine triphosphate-regulated potassium channels. | BACKGROUND/AIMS: Eribis peptide 94 (EP 94) is a new enkephalin derivative which potently binds to the µ- and ä-opioid receptor. In this study, we determined the effects of EP 94 and potential mechanism(s) involved in cardioprotection of the rat heart.METHODS AND RESULTS: An acute (5 and10 min into ischemia) and a chron... | ['Animals', 'Benzamides', 'Cardiotonic Agents', 'Decanoic Acids', 'Enkephalins', 'Hydroxy Acids', 'KATP Channels', 'Male', 'Myocardial Reperfusion Injury', 'Nitric Oxide', 'Nitric Oxide Synthase', 'Nitric Oxide Synthase Type II', 'Potassium Channel Blockers', 'Rats', 'Rats, Sprague-Dawley', 'Receptors, Opioid, delta', ... | 22,814,415 | [['B01.050'], ['D02.065.277', 'D02.241.223.100.100', 'D02.455.426.559.389.127.085'], ['D27.505.954.411.222', 'D27.720.799.080'], ['D10.251.175'], ['D12.644.400.575.281', 'D12.776.631.650.575.281'], ['D02.241.511'], ['D12.776.157.530.400.600.450.550', 'D12.776.543.550.450.750.450.550', 'D12.776.543.585.400.750.450.550']... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Accurate detection of anomalies by routine ultrasonography in an indigent clinic population. | OBJECTIVE: The study's objective was to determine the accuracy of routine ultrasonography in the detection of anomalies in an indigent clinic population by sonographers trained to perform complete anatomic screens.STUDY DESIGN: This is a retrospective study of women undergoing obstetric ultrasonography between 15 and 2... | ['Abortion, Induced', 'Adult', 'Congenital Abnormalities', 'False Negative Reactions', 'Female', 'Gestational Age', 'Humans', 'Infant, Newborn', 'Poverty', 'Pregnancy', 'Pregnancy Outcome', 'Risk Factors', 'Sensitivity and Specificity', 'Ultrasonography, Prenatal'] | 9,790,383 | [['E04.520.050'], ['M01.060.116'], ['C16.131'], ['E01.354.340'], ['G07.345.500.325.235.968', 'G08.686.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['I01.880.735.634', 'I01.880.853.996.535', 'N01.824.600'], ['G08.686.784.769'], ['E01.789.700', 'G08.686.784.769.496'], ['E05.318.740.600.800... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Disguised as a Sulfate Reducer: Growth of the Deltaproteobacterium Desulfurivibrio alkaliphilus | This study demonstrates that the deltaproteobacterium Desulfurivibrio alkaliphilus can grow chemolithotrophically by coupling sulfide oxidation to the dissimilatory reduction of nitrate and nitrite to ammonium. Key genes of known sulfide oxidation pathways are absent from the genome of D. alkaliphilus Instead, the geno... | ['Ammonium Compounds', 'Chemoautotrophic Growth', 'Deltaproteobacteria', 'Gene Expression Profiling', 'Metabolic Networks and Pathways', 'Nitrates', 'Nitrites', 'Oxidation-Reduction', 'Sulfides', 'Sulfur'] | 28,720,728 | [['D01.625.062'], ['G02.111.071.314', 'G03.087.314'], ['B03.660.125'], ['E05.393.332'], ['G03.493'], ['D01.248.497.158.606', 'D01.625.525.550', 'D02.583'], ['D01.248.497.158.635', 'D01.625.600.600', 'D02.633'], ['G02.700', 'G03.295.531'], ['D01.248.497.158.874', 'D01.875.350.850', 'D02.886.520'], ['D01.268.185.900']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Developing a global psychotherapeutic approach to schizophrenia: results of a five-year follow-up. | This is an account of a long-range action research project to determine indications for and effects of a comprehensive psychotherapeutic approach, including various treatment modalities, in the treatment of schizophrenics. Four diagnostic groups were established among the 100 patients. In the course of data analysis, t... | ['Adolescent', 'Adult', 'Crisis Intervention', 'Ego', 'Employment', 'Family Therapy', 'Follow-Up Studies', 'Humans', 'Middle Aged', 'Prognosis', 'Psychotherapy', 'Psychotic Disorders', 'Regression, Psychology', 'Schizophrenia', 'Schizophrenia, Paranoid', 'Schizophrenic Psychology', 'Therapeutic Community'] | 4,049,919 | [['M01.060.057'], ['M01.060.116'], ['F04.754.252'], ['F01.752.747.189', 'F02.739.794.206'], ['N01.824.245'], ['F04.754.864.581.273'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.789'], ['F04.754'],... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Assessing clusters and motifs from gene expression data. | Large-scale gene expression studies and genomic sequencing projects are providing vast amounts of information that can be used to identify or predict cellular regulatory processes. Genes can be clustered on the basis of the similarity of their expression profiles or function and these clusters are likely to contain gen... | ['Amino Acid Motifs', 'Animals', 'Cell Cycle', 'Computational Biology', 'Databases, Factual', 'Drosophila melanogaster', 'Forkhead Transcription Factors', 'Gene Expression Profiling', 'Helix-Loop-Helix Motifs', 'Humans', 'Mice', 'Multigene Family', 'Nuclear Proteins', 'Rats', 'Saccharomyces cerevisiae', 'Transcription ... | 11,156,620 | [['G02.111.570.820.709.275.500', 'G02.111.570.820.709.600.500'], ['B01.050'], ['G04.144'], ['H01.158.273.180', 'L01.313.124'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['B01.050.500.131.617.720.500.500.750.310.250.500'], ['D12.776.260.950.249', 'D12.776.930.977.249'], ['E05.393.332'], ['G02.111.570.820.709.2... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Modulation by glycosphingolipids of membrane-membrane interactions induced by myelin basic protein and melittin. | The effect of glycosphingolipids (GSLs) with oligosaccharide chains of different length and charge on membrane-membrane interactions induced by myelin basic protein (MBP) or melittin (Mel) was comparatively investigated with small unilamellar vesicles. MBP induces a fast vesicle aggregation and close membrane appositio... | ['Cell Membrane Permeability', 'Fluorescence Polarization', 'Glycosphingolipids', 'Lipid Bilayers', 'Melitten', 'Membrane Fusion', 'Myelin Basic Protein'] | 1,384,707 | [['G03.143.335', 'G04.175'], ['E05.196.712.516.600.390'], ['D09.400.410.420', 'D10.390.470', 'D10.570.877.360'], ['D10.570.510', 'J01.637.087.500.510'], ['D12.644.050.550', 'D12.776.543.695.054.550', 'D20.888.065.115.580', 'D23.946.833.065.115.580'], ['G04.575'], ['D12.776.543.620.540', 'D12.776.631.580.510']] | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Magnetic resonance histology: in situ single cell imaging of receptor cells in an invertebrate (Lolliguncula brevis, Cephalopoda) sense organ. | Utilizing contrast-enhanced MR histology, individual cell bodies were identified in situ and compared one-to-one with conventional histology. The squid Lolliguncula brevis served as a model where the receptor cells of the proprioceptive neck receptor organ were labeled with paramagnetic cobalt(II) ions by conventional ... | ['Animals', 'Cobalt', 'Decapodiformes', 'Female', 'Indicators and Reagents', 'Magnetic Resonance Imaging', 'Magnetic Resonance Spectroscopy', 'Male', 'Microscopy', 'Models, Animal', 'Proprioception', 'Sense Organs', 'Sensory Receptor Cells'] | 14,684,205 | [['B01.050'], ['D01.268.556.185', 'D01.268.956.155', 'D01.552.544.185'], ['B01.050.500.644.116.150'], ['D27.720.470.410'], ['E01.370.350.825.500'], ['E05.196.867.519'], ['E01.370.350.515', 'E05.595', 'H01.671.617.562'], ['E05.598'], ['F02.830.816.541', 'G07.888.750', 'G11.561.790.541'], ['A09'], ['A08.675.650.915', 'A0... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
[Chemotherapy for bladder cancer: 2012 Update. From AUO ("Arbeitsgemeinschaft Urologische Onkologie") and IABC ("Interdisziplin?re Arbeitsgruppe BlasenCarcinom")]. | This article summarizes contemporary standards in systemic therapy for urothelial carcinoma as well as updated results of peer-reviewed publications and international bladder cancer meetings in 2011. Both neoadjuvant and adjuvant trials for locally advanced carcinoma and data on systemic chemotherapy for metastatic bla... | ['Antineoplastic Agents', 'Drug Therapy', 'Germany', 'Humans', 'Medical Oncology', 'Urinary Bladder Neoplasms', 'Urology'] | 22,526,172 | [['D27.505.954.248'], ['E02.319'], ['Z01.542.315'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H02.403.429.515'], ['C04.588.945.947.960', 'C12.758.820.968', 'C12.777.829.813', 'C13.351.937.820.945', 'C13.351.968.829.707'], ['H02.403.810.860']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 |
Long-term Results of Troublesome CWD Cavity Reconstruction by Mastoid and Epitympanic Bony Obliteration (CWR-BOT) in Adults. | OBJECTIVE: To present the long-term surgical outcome of the bony mastoid and epitympanic obliteration technique with canal wall reconstruction (CWR-BOT) in adults with an unstable cavity after previous canal wall-down surgery for extensive cholesteatoma.STUDY DESIGN: Retrospective study.INTERVENTIONS: Therapeutic.SETTI... | ['Adult', 'Cholesteatoma, Middle Ear', 'Ear Canal', 'Female', 'Hearing', 'Hearing Tests', 'Humans', 'Male', 'Mastoid', 'Otologic Surgical Procedures', 'Postoperative Period', 'Retrospective Studies', 'Treatment Outcome'] | 27,023,012 | [['M01.060.116'], ['C09.218.200', 'C17.800.428.260.300'], ['A09.246.272.396'], ['F02.830.816.263', 'G07.888.500', 'G11.561.790.263'], ['E01.370.382.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.232.781.885.444'], ['E04.580.450'], ['E04.614.750', 'N02.421.585.753.750'], ['E05.318.372.500.500.500', 'E... | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Influence of different volume therapies on platelet function in the critically ill. | OBJECTIVE: Both albumin and synthetic colloids such as hydroxyethyl starch (HES) solution are used to optimize hemodynamics in the critically ill. The influence of different long-term infusion regimes on platelet function was studied.DESIGN: Prospective, randomized study.SETTING: Clinical investigation on a university ... | ['Adult', 'Aged', 'Critical Illness', 'Female', 'Fluid Therapy', 'Hemodynamics', 'Humans', 'Hydroxyethyl Starch Derivatives', 'Male', 'Middle Aged', 'Molecular Weight', 'Multiple Trauma', 'Plasma Substitutes', 'Platelet Aggregation', 'Postoperative Complications', 'Prospective Studies', 'Sepsis', 'Serum Albumin', 'Time... | 8,923,073 | [['M01.060.116'], ['M01.060.116.100'], ['C23.550.291.625'], ['E02.319.360'], ['G09.330.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D09.301.915.500', 'D09.698.365.855.500'], ['M01.060.116.630'], ['G02.494'], ['C26.640'], ['D27.505.954.502.140.500'], ['G09.188.370.687', 'G09.188.390.600.640'], ['C23.550.767... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Topography of neovascularity in human prostate carcinoma. | BACKGROUND: All neoplasms require angiogenesis and resulting neovascularity for growth. The authors and others have confirmed the staging and prognostic significance of quantitative microvascularity density (MVD) in human prostate carcinoma (CAP). In the present investigation, the authors sought to identify the specifi... | ['Carcinoma', 'Humans', 'Keratins', 'Male', 'Microcirculation', 'Necrosis', 'Neoplasm Staging', 'Neovascularization, Pathologic', 'Prognosis', 'Prostate', 'Prostatic Neoplasms', 'von Willebrand Factor'] | 7,537,624 | [['C04.557.470.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D05.750.078.593.450', 'D12.776.220.475.450', 'D12.776.860.607'], ['G09.330.100.645'], ['C23.550.717'], ['E01.789.625'], ['C23.550.589.500'], ['E01.789'], ['A05.360.444.575', 'A10.336.707'], ['C04.588.945.440.770', 'C12.294.260.750', 'C12.294.565.6... | ['Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Biochemical change in the liver and kidney of rats following parathyroidectomy. | The effect of hypoparathyroidism and low blood calcium on enzyme levels in rat liver and kidney is shown. Four animal groups were used: parathyroidectomized (PTX), PTX with CaCl2 added in the drinking water, sham-operated controls and sham-operated with CaCl2 added in the drinking water. PTX significantly lowered serum... | ['Animals', 'Calcium', 'Glucosephosphate Dehydrogenase', 'Kidney', 'Lipids', 'Liver', 'Malate Dehydrogenase', 'Parathyroid Glands', 'Parathyroid Hormone', 'Rats', 'Rats, Inbred Strains'] | 4,006,901 | [['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D08.811.682.047.150.300'], ['A05.810.453'], ['D10'], ['A03.620'], ['D08.811.682.047.820.496'], ['A06.300.560'], ['D06.472.699.590', 'D12.644.548.587'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760', 'B01.050.150.900.649.313... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Hemodynamic responses to dopamine infusion at controlled normal and low cardiac output states in the anesthetized dog. | In order to isolate the renal and pulmonary vascular effects of dopamine, we employed a dog preparation utilizing fixed venous return in order to control cardiac output at either a normal or low flow state. Dopamine infusion was carried out at doses of 8 and 16 microng/Kg./min. Heart rate, mean systemic arterial pressu... | ['Animals', 'Blood Flow Velocity', 'Blood Pressure', 'Cardiac Output', 'Dogs', 'Dopamine', 'Heart Rate', 'Hemodynamics', 'Infusions, Parenteral', 'Kidney'] | 850,435 | [['B01.050'], ['E01.370.370.130', 'G09.330.380.630.080'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E01.370.370.380.150', 'G09.330.380.124'], ['B01.050.150.900.649.313.750.250.216.200'], ['D02.092.211.215.406', 'D02.092.311.342', 'D02.455.426.559.389.657.166.175.342'], ['E01.370.600.875.500', 'G09.330.380.500'], ['... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Helical motion analysis of the knee--I. Methodology for studying kinematics during locomotion. | A technique for investigating the three-dimensional kinematics of knee motion during dynamic functional tasks has been developed. It involves the combined usage of a six degree of freedom goniometer and helical motion analysis. A detailed procedure for coordinate system alignment and calibration must be followed. Once ... | ['Humans', 'Kinesis', 'Knee Injuries', 'Knee Joint', 'Locomotion', 'Male', 'Models, Biological'] | 3,611,121 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.113.700'], ['C26.558.554'], ['A02.835.583.475'], ['G07.568.500', 'G11.427.410.568'], ['E05.599.395']] | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Photoprotection enhanced by red cell wall pigments in three East Antarctic mosses. | BACKGROUND: Antarctic bryophytes (mosses and liverworts) are resilient to physiologically extreme environmental conditions including elevated levels of ultraviolet (UV) radiation due to depletion of stratospheric ozone. Many Antarctic bryophytes synthesise UV-B-absorbing compounds (UVAC) that are localised in their cel... | ['Analysis of Variance', 'Antarctic Regions', 'Bryophyta', 'Cell Wall', 'Chromatography, High Pressure Liquid', 'Microscopy, Confocal', 'Pigmentation', 'Pigments, Biological', 'Plant Leaves', 'Seasons', 'Spectroscopy, Fourier Transform Infrared', 'Time Factors', 'Ultraviolet Rays'] | 30,463,628 | [['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['Z01.158'], ['B01.650.940.800.575.137'], ['A11.284.183'], ['E05.196.181.400.300'], ['E01.370.350.515.395', 'E05.595.395'], ['E01.370.600.620', 'G16.690'], ['D23.767'], ['A18.024.812'], ['G01.910.645.661', 'G16.500.275.071.590', 'N06.230.300.100.250.52... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Identification of reliable marker genes for the detection of canine fecal contamination in sub-tropical Australia. | Animal fecal contamination in aquatic environments is a major source of zoonotic diseases in humans. While concerns are focused on livestock, companion animals such as dogs can also be a source of a wide range of zoonotic pathogens. Therefore, detection of dog or canine fecal contamination in aquatic environments is im... | ['Animals', 'Australia', 'Dogs', 'Environmental Monitoring', 'Feces', 'Water Microbiology', 'Water Pollution'] | 32,105,941 | [['B01.050'], ['Z01.639.100', 'Z01.678.100.373'], ['B01.050.150.900.649.313.750.250.216.200'], ['N06.850.460.350.080', 'N06.850.780.375'], ['A12.459'], ['H01.158.273.540.274.777', 'N06.850.425.450'], ['N06.850.460.790']] | ['Organisms [B]', 'Geographicals [Z]', 'Health Care [N]', 'Anatomy [A]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
Inhibition of cardiolipin biosynthesis in the hypoxic rat heart. | Cardiolipin is the principal polyglycerophospholipid in the heart. The effect of hypoxia on cardiolipin biosynthesis was investigated in isolated rat hearts perfused in the Langendorff mode. Hearts were pulsed-labeled for 60 min with 0.1 mM [1,(3)-3H]glycerol in Krebs Henseleit buffer saturated with either 95% O2/5% CO... | ['Adenosine Triphosphate', 'Animals', 'Cardiolipins', 'Cytidine Diphosphate Diglycerides', 'Cytidine Triphosphate', 'Hypoxia', 'Male', 'Myocardium', 'Nucleotidyltransferases', 'Phosphatidylglycerols', 'Rats', 'Rats, Sprague-Dawley'] | 7,651,078 | [['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['B01.050'], ['D10.570.755.375.760.400.885.185', 'D23.050.550.480.330'], ['D03.383.742.686.246.150.210', 'D09.408.620.569.200', 'D13.695.740.246.150.210', 'D13.695.827.232.150.210', 'D13.695.827.708.260'], ['D03.383.742.686.246.400', 'D13.6... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Selection acting upon slow-migrating ADH alleles differing in enzyme activity. | Relative egg to adult viability was compared in three stocks of Drosophila melanogaster differing in alcohol dehydrogenase (ADH) activity. Two of these, Grell's standard ADHS and a mutant ADHS strain producing half the normal number of ADH molecules, had the same electrophoretic mobility. The experiment demonstrated a ... | ['Alcohol Oxidoreductases', 'Alleles', 'Animals', 'Drosophila melanogaster', 'Polymorphism, Genetic', 'Selection, Genetic'] | 408,303 | [['D08.811.682.047'], ['G05.360.340.024.340.030'], ['B01.050'], ['B01.050.500.131.617.720.500.500.750.310.250.500'], ['G05.365.795'], ['G05.783']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Age at onset in mesial temporal lobe epilepsy with a history of febrile seizures. | The authors demonstrated that temporal lobe epilepsy with hippocampal sclerosis preceded by febrile seizures can be divided into different groups according to age at epilepsy onset (AEO). AEO was found to be trimodal with a peak at ages 5.5, 15.3, and 26.7. In the adolescent AEO group, a family history of epilepsy occu... | ['Adolescent', 'Adult', 'Age of Onset', 'Child', 'Child, Preschool', 'Epilepsy, Temporal Lobe', 'Female', 'Hippocampus', 'Humans', 'Male', 'Probability', 'Retrospective Studies', 'Sclerosis', 'Seizures, Febrile'] | 15,477,557 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075.100', 'N06.850.490.250.100'], ['M01.060.406'], ['M01.060.406.448'], ['C10.228.140.490.360.290', 'C10.228.140.490.493.375'], ['A08.186.211.180.405', 'A08.186.211.200.885.287.500.345'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.600', 'G17.680', 'N0... | ['Named Groups [M]', 'Health Care [N]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Extraperitoneal cicatricial hernia repair with implantation of non-resorbable synthetic mesh]. | Large incisional hernias and recurrences were treated by extraperitoneal implantation of polypropylene mesh using a sublay technique in 37 patients. There were 10 minor (5 haematoma, 3 seroma, 2 patients with postoperative increased temperature) and 2 major complications (1 case of skin necorsis, 1 deed wound infection... | ['Adult', 'Aged', 'Cicatrix', 'Female', 'Follow-Up Studies', 'Hernia, Ventral', 'Humans', 'Male', 'Middle Aged', 'Postoperative Complications', 'Prostheses and Implants', 'Reoperation', 'Surgical Mesh'] | 9,574,358 | [['M01.060.116'], ['M01.060.116.100'], ['A10.165.450.300', 'C23.550.355.274', 'G16.762.891.249'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['C23.300.707.374.937'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C23.550.767'], ['E07.695'], ['E04.... | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A spatio-temporal index for heat vulnerability assessment. | The public health consequences of extreme heat events are felt most intensely in metropolitan areas where population density is high and the presence of the urban heat island phenomenon exacerbates the potential for prolonged exposure. This research develops an approach to map potential heat stress on humans by combini... | ['Cities', 'Environmental Exposure', 'Hot Temperature', 'Humans', 'Ontario', 'Spatial Analysis'] | 22,270,590 | [['G16.500.275.069', 'N06.230.069', 'Z01.433'], ['N06.850.460.350'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.775.710.380', 'N06.230.300.100.725.232', 'N06.230.300.100.725.710.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.107.567.176.639'], ['E05.318.740.933', 'N05.715.360.750.746... | ['Phenomena and Processes [G]', 'Health Care [N]', 'Geographicals [Z]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Rejoining of double-stranded DNA-fragments studied in different size-intervals. | PURPOSE: To measure rejoining of radiation-induced doublestranded DNA-fragments of different sizes and to evaluate the effects of size-resolution in the analysis of rejoining.MATERIAL AND METHODS: Normal human fibroblasts (GM5758) were irradiated with photons or accelerated nitrogen ions (linear energy transfer, LET = ... | ['Cell Line', 'Cobalt Radioisotopes', 'DNA', 'DNA Damage', 'DNA Fragmentation', 'DNA Repair', 'Electrophoresis, Agar Gel', 'Fibroblasts', 'Humans', 'Ions', 'Nitrogen', 'Photons', 'Time Factors'] | 11,747,548 | [['A11.251.210'], ['D01.268.556.185.500.354', 'D01.268.956.155.500.354', 'D01.496.239.354', 'D01.496.749.256', 'D01.552.544.185.500.354'], ['D13.444.308'], ['G05.200'], ['G05.200.230'], ['G02.111.222', 'G05.219'], ['E05.196.401.153', 'E05.301.300.100'], ['A11.329.228'], ['B01.050.150.900.649.313.988.400.112.400.400'], ... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Enhanced glomerular prostaglandin formation in experimental membranous nephropathy. | To determine whether the induction of immune-mediated glomerular injury influences the formation of cyclooxygenase products by glomerular cells, we determined prostaglandin E2 (PGE2) and thromboxane B2 (TXB2) (as the stable metabolite of TXA2) formation in isolated glomeruli of rats with passive Heymann nephritis (PHN)... | ['Animals', 'Complement C3', 'Dinoprostone', 'Glomerulonephritis', 'Imidazoles', 'Kidney Glomerulus', 'Male', 'Prostaglandins', 'Prostaglandins E', 'Rats', 'Rats, Inbred Strains', 'Thromboxane B2'] | 3,474,470 | [['B01.050'], ['D12.776.124.050.140', 'D12.776.124.486.274.250'], ['D10.251.355.255.550.250.200', 'D23.469.050.175.725.250.200'], ['C12.777.419.570.363', 'C13.351.968.419.570.363'], ['D03.383.129.308'], ['A05.810.453.324.359', 'A05.810.453.736.520'], ['D10.251.355.255.550', 'D23.469.050.175.725'], ['D10.251.355.255.550... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Trends in Treatment Patterns and Clinical Outcomes in Young Women Diagnosed With Ductal Carcinoma In Situ. | BACKGROUND: Although it is known that the risk of a second breast cancer event among young women diagnosed with ductal carcinoma in situ (DCIS) is higher than in older women, the effect of current treatment options on long-term outcomes in this subgroup of women remains poorly defined. We aimed to evaluate national tre... | ['Adult', 'Age Factors', 'Breast Neoplasms', 'Carcinoma, Intraductal, Noninfiltrating', 'Disease-Free Survival', 'Female', 'Humans', 'Mastectomy', 'Neoplasms, Second Primary', "Practice Patterns, Physicians'", 'Radiotherapy, Adjuvant', 'Retrospective Studies', 'SEER Program'] | 28,941,977 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['C04.588.180', 'C17.800.090.500'], ['C04.557.470.200.025.275', 'C04.557.470.200.240.187.250', 'C04.557.470.615.275'], ['E01.789.800.190', 'E05.318.740.998.300', 'N04.761.559.590.800.190', 'N05.715.360.575.575.800.190', 'N05.715.360.750.795.300', 'N06.850.520.83... | ['Named Groups [M]', 'Health Care [N]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Gnathostoma binucleatum: pathological and parasitological aspects in experimentally infected dogs. | Lesions and antibody kinetics produced by inoculation of Gnathostoma binucleatum larvae into dogs are described, as well as the morphology of the recovered parasites. In four out of five infected bitches parasite phases were found in the stomach. Only one bitch eliminated eggs and adult parasite phases in feces. In thi... | ['Animals', 'Antibodies, Helminth', 'Dogs', 'Feces', 'Female', 'Gnathostoma', 'Gnathostomiasis', 'Larva', 'Male', 'Microscopy, Electron, Scanning', 'Stomach', 'Turtles'] | 20,599,438 | [['B01.050'], ['D12.776.124.486.485.114.185', 'D12.776.124.790.651.114.185', 'D12.776.377.715.548.114.185'], ['B01.050.150.900.649.313.750.250.216.200'], ['A12.459'], ['B01.050.500.500.294.400.937.700.722.375'], ['C01.610.335.508.700.750.380'], ['B05.500.500', 'G07.345.500.550.500.500'], ['E01.370.350.515.402.541', 'E0... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Fast acceleration of ASL-based time-resolved magnetic resonance angiography by acquisition of control and labeled images in the same shot (fast ACTRESS): An optimization study. | PURPOSE: To establish an optimized sequence design for fast acceleration of arterial spin labeling (ASL)-based time-resolved magnetic resonance angiography (MRA) by acquisition of control and labeled images in the same shot (fast ACTRESS) and a scan time of <1min, for the evaluation of intracranial vessels.MATERIALS AN... | ['Adult', 'Algorithms', 'Anterior Cerebral Artery', 'Area Under Curve', 'Arteries', 'Brain', 'Brain Mapping', 'Constriction, Pathologic', 'Female', 'Healthy Volunteers', 'Hemodynamics', 'Humans', 'Image Processing, Computer-Assisted', 'Imaging, Three-Dimensional', 'Magnetic Resonance Angiography', 'Magnetic Resonance I... | 28,754,270 | [['M01.060.116'], ['G17.035', 'L01.224.050'], ['A07.015.114.228.100'], ['E05.318.740.200', 'G03.787.101', 'G07.690.725.064', 'N06.850.520.830.200'], ['A07.015.114'], ['A08.186.211'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['C23.300.287'], ['M01.774.500', 'M01.955.236'], ['G09.330.380... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Natural history and outcome in systemic AA amyloidosis. | BACKGROUND: Deposition of amyloid fibrils derived from circulating acute-phase reactant serum amyloid A protein (SAA) causes systemic AA amyloidosis, a serious complication of many chronic inflammatory disorders. Little is known about the natural history of AA amyloidosis or its response to treatment.METHODS: We evalua... | ['Adolescent', 'Adult', 'Age of Onset', 'Aged', 'Aged, 80 and over', 'Amyloidosis', 'Arthritis', 'Child', 'Disease Progression', 'Familial Mediterranean Fever', 'Female', 'Humans', 'Infections', 'Kaplan-Meier Estimate', 'Kidney Failure, Chronic', 'Male', 'Middle Aged', 'Risk Factors', 'Serum Amyloid A Protein'] | 17,554,117 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075.100', 'N06.850.490.250.100'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C18.452.845.500'], ['C05.550.114'], ['M01.060.406'], ['C23.550.291.656'], ['C16.320.382.625'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C01'], ['E05.318.740.998.650', 'N05.715.360... | ['Named Groups [M]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Cytopathologic analysis of pericardial effusions in 116 cases: Implications for poor prognosis in lung cancer patients with positive interpretations. | BACKGROUND: Few studies have evaluated the cytology of pericardial effusions. The aim of this study is to investigate the etiologies of pericardial effusions and to establish the relationship between cytopathologic interpretations and outcome patterns among patients with pericardial effusions.METHODS: We identified 116... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Female', 'Humans', 'Kaplan-Meier Estimate', 'Lung Neoplasms', 'Male', 'Middle Aged', 'Pericardial Effusion', 'Young Adult'] | 28,139,896 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.998.650', 'N05.715.360.750.795.650', 'N06.850.520.830.998.650'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['M01.060.116.630'], ['C14.280.695'], ['M01.060.116.815'... | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Effects of hypotensive anesthesia in anterior maxillary osteotomy. | Deliberate hypotension, as a means of reducing loss of blood, providing a more ideal operative field, and shortening operating time, has been used in other surgical disciplines, such as neurosurgery, vascular surgery, and orthopedic surgery. This controlled study compared the effects of hypotensive and normotensive ane... | ['Anesthesia, Dental', 'Anesthesia, General', 'Blood Pressure', 'Blood Volume', 'Hematocrit', 'Humans', 'Hypotension, Controlled', 'Maxilla', 'Oral Hemorrhage', 'Osteotomy', 'Time Factors'] | 6,966,683 | [['E03.155.141', 'E06.045'], ['E03.155.197'], ['E01.370.600.875.249', 'G09.330.380.076'], ['G09.188.130', 'G09.330.380.092'], ['E01.370.225.625.400', 'E05.200.625.400', 'G09.188.370.374'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E03.545'], ['A02.835.232.781.324.502.645', 'A14.521.645'], ['C07.465.625', 'C23.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Knapp's law and unilateral axial high myopia. 1970. | BACKGROUND AND PURPOSE: (Hermann) Knapp's Law states, in essence, that in axial ametropia, if the correcting lens is placed so that its second equivalent point coincides with the anterior focus of the eye (ca 15 mm in front of the eye), the size of the retinal image is not different from that in the normal eye. The adv... | ['Aniseikonia', 'History, 20th Century', 'Humans', 'Myopia', 'Ophthalmology'] | 10,553,115 | [['C11.744.116'], ['K01.400.504.968'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C11.744.636'], ['H02.403.810.468']] | ['Diseases [C]', 'Humanities [K]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Cardiac desensitization to adenosine analogues after prolonged R-PIA infusion in vivo. | To determine the effects of chronic in vivo stimulation of adenosine receptors, R-(-)-N6-(2-phenylisopropyl)adenosine (R-PIA), a selective A1 receptor agonist, was administered to rats as a continuous 7-day infusion (200 nmol/h). Inotropic and chronotropic responses of isolated atria to adenosine receptor agonists were... | ['2-Chloroadenosine', 'Adenosine', "Adenosine-5'-(N-ethylcarboxamide)", 'Animals', 'Carbachol', 'Down-Regulation', 'GTP-Binding Proteins', 'Heart', 'Heart Atria', 'In Vitro Techniques', 'Male', 'Myocardium', 'Phenylisopropyladenosine', 'Rats', 'Rats, Wistar', 'Receptors, Purinergic P1', 'Time Factors'] | 8,285,230 | [['D03.633.100.759.590.138.300', 'D13.570.583.138.300', 'D13.570.800.096.300'], ['D03.633.100.759.590.138', 'D13.570.583.138', 'D13.570.800.096'], ['D03.633.100.759.590.138.025', 'D13.570.583.138.025', 'D13.570.800.096.250'], ['B01.050'], ['D02.092.877.883.333.115', 'D02.675.276.232.115'], ['G02.111.240', 'G05.308.200'... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Long-term evaluation of estimates of need for third molar removal. | PURPOSE: The aim of this study was to evaluate the estimates on need for third molar removals made at age 20 after 12 years.PATIENTS AND METHODS: The series consisted of 81 university students followed from age 20 to 32 years. At baseline and at study end, these students were clinically examined, and panoramic radiogra... | ['Adult', 'Chi-Square Distribution', 'Decision Making', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Molar, Third', 'Needs Assessment', "Practice Patterns, Dentists'", 'Prospective Studies', 'Surveys and Questionnaires', 'Tooth Extraction'] | 10,716,110 | [['M01.060.116'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['F02.463.785.373'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A14.549.167.860.525.500'], ['I02.594', 'N03.3... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Anatomy [A]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Bacterial Contamination into Ready-to-Eat Foods Sold in Middle Thailand. | ?Bacterial contamination in ready-to-eat (RTE) foods prepared and sold by small businesses in middle Thailand was surveyed. The 135 samples were randomly purchased from open markets and supermarkets in Bangkok and Pathum Thani provinces during May 2013 to February 2015. The results indicated that the rate of contaminat... | ['Animals', 'Bacteria', 'Bacterial Load', 'Fast Foods', 'Food Contamination', 'Food Microbiology', 'Foodborne Diseases', 'Humans', 'Thailand'] | 28,003,629 | [['B01.050'], ['B03'], ['E01.370.225.875.150.115', 'E01.370.225.875.220.115', 'E05.200.875.150.115', 'E05.200.875.220.115', 'G06.099.100'], ['G07.203.300.477', 'J02.500.477'], ['J01.576.423.850.730.500.249', 'N06.850.460.400', 'N06.850.601.500.249'], ['H01.158.273.540.274.332', 'J01.576.423.850.730.500.249.300', 'N06.8... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 |
The heparin-binding proteome in normal pancreas and murine experimental acute pancreatitis. | Acute pancreatitis (AP) is acute inflammation of the pancreas, mainly caused by gallstones and alcohol, driven by changes in communication between cells. Heparin-binding proteins (HBPs) play a central role in health and diseases. Therefore, we used heparin affinity proteomics to identify extracellular HBPs in pancreas ... | ['Animals', 'Biomarkers', 'Disease Models, Animal', 'Heparin', 'Homeostasis', 'Humans', 'Mice', 'Pancreas', 'Pancreatitis', 'Protein Binding', 'Proteins', 'Proteome', 'Proteomics', 'Serum Amyloid A Protein', 'alpha-2-HS-Glycoprotein'] | 31,211,768 | [['B01.050'], ['D23.101'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['D09.698.373.400'], ['G07.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649.313.992.635.505.500'], ['A03.734'], ['C06.689.750'], ['G02.111.679', 'G03.808'], ['D12.776'], ['D12.776.817'], ['H01.158.201.843', 'H01.158.2... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
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