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SLIT2 inhibits cell migration in colorectal cancer through the AKT-GSK3â signaling pathway. | PURPOSE: Colorectal cancer is a common malignancy and one of the major causes of cancer-related deaths worldwide. Similar to other human cancers, tumor metastasis is the biggest obstacle in the clinical treatment of colorectal cancer. In this study, we explored the functional role of SLIT2 in colon tumor metastasis and... | ['Aged', 'Biomarkers, Tumor', 'Cell Line, Tumor', 'Cell Movement', 'Colorectal Neoplasms', 'Down-Regulation', 'Epithelial Cells', 'Epithelial-Mesenchymal Transition', 'Female', 'Glycogen Synthase Kinase 3', 'Glycogen Synthase Kinase 3 beta', 'Humans', 'Intercellular Signaling Peptides and Proteins', 'Male', 'Middle Age... | 23,314,850 | [['M01.060.116.100'], ['D23.101.140'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.198', 'G07.568.500.180'], ['C04.588.274.476.411.307', 'C06.301.371.411.307', 'C06.405.249.411.307', 'C06.405.469.158.356', 'C06.405.469.491.307', 'C06.405.469.860.180'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['A11.436'], [... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Computer-Assisted Decision Support System in Pulmonary Cancer detection and stage classification on CT images. | Pulmonary cancer is considered as one of the major causes of death worldwide. For the detection of lung cancer, computer-assisted diagnosis (CADx) systems have been designed. Internet-of-Things (IoT) has enabled ubiquitous internet access to biomedical datasets and techniques; in result, the progress in CADx is signifi... | ['Algorithms', 'Databases, Factual', 'Decision Making', 'Decision Support Systems, Clinical', 'Diagnosis, Computer-Assisted', 'Humans', 'Image Processing, Computer-Assisted', 'Internet', 'Lung', 'Lung Neoplasms', 'Machine Learning', 'Neoplasm Staging', 'Neural Networks, Computer', 'Pattern Recognition, Automated', 'Sof... | 29,366,586 | [['G17.035', 'L01.224.050'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['F02.463.785.373'], ['L01.313.500.750.300.190'], ['E01.158', 'L01.313.500.750.100.158'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['L01.224.230.110.500'], ['A04.411'], ['C04.588.894.797.520', 'C08.381.540', 'C08.7... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Hospital-based safety and tolerability study to assess efficacy of oral doxycycline in the treatment of Wuchereria bancrofti infection in north-eastern Tanzania. | A hospital based open-label clinical trial of 19 apparently healthy adult males with microfilaraemia was conducted to assess safety, tolerability and efficacy of doxycycline on Wuchereria bancrofti. Study individuals were assigned 8 weeks treatment with doxycycline 200 mg daily. The results of different selected tests ... | ['Administration, Oral', 'Adolescent', 'Adult', 'Aged', 'Animals', 'Doxycycline', 'Drug Evaluation', 'Drug-Related Side Effects and Adverse Reactions', 'Filariasis', 'Humans', 'Male', 'Middle Aged', 'Tanzania', 'Wuchereria bancrofti'] | 18,254,502 | [['E02.319.267.100'], ['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['B01.050'], ['D02.455.426.559.847.562.900.200', 'D04.615.562.900.200'], ['E05.290.625', 'E05.337.425'], ['C25.100'], ['C01.610.335.508.700.750.361'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['Z01.058.290.120.840'... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
Effect of amphotericin B on cholesterol-containing liposomes of egg phosphatidylcholine and didocosenoyl phosphatidylcholine. A refinement of the model for the formation of pores by amphotericin B in membranes. | (1) Binding and K+-permeability measurements were performed on egg and 22 : 1c/22 : 1c-phosphatidylcholine liposomes with or without cholesterol. (2) Amphotericin B binds specifically to cholesterol in both types of liposome despite the difference in bilayer thickness. (3) Addition of amphotericin B to one side of the ... | ['Amphotericin B', 'Binding Sites', 'Cholesterol', 'Eggs', 'Fatty Acids, Unsaturated', 'Ion Channels', 'Liposomes', 'Models, Biological', 'Permeability', 'Phosphatidylcholines', 'Potassium'] | 687,620 | [['D02.540.576.500.500'], ['G02.111.570.120'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['G07.203.300.470', 'J02.500.470'], ['D10.251.355'], ['D12.776.157.530.400', 'D12.776.543.550.450', 'D12.776.543.585.400'], ['D25.479.517', 'D26.255.260.517', 'J01.637.051.479.517', 'J01.637.087.500... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Reducing major lower extremity amputations after the introduction of a multidisciplinary team in patient with diabetes foot ulcer. | BACKGROUND: Diabetic foot ulceration is receiving more attention because of its high amputation and mortality rate. It is essential to establish the frequency of amputations in people with diabetes after any change to the management of diabetic foot care. The present study aim to compare the frequency of lower-extremit... | ['Aged', 'Amputation', 'Diabetic Foot', 'Humans', 'Interprofessional Relations', 'Patient Care Team', 'Prognosis', 'Program Evaluation', 'Quality of Health Care', 'Retrospective Studies'] | 27,388,440 | [['M01.060.116.100'], ['E04.555.080'], ['C14.907.320.191', 'C17.800.893.592.450.200', 'C19.246.099.500.191', 'C19.246.099.937.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.401.205'], ['N04.590.715'], ['E01.789'], ['E05.337.820', 'N04.761.685', 'N05.715.360.650'], ['N04.761', 'N05.715'], ['E05.318.37... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Diversification and the evolution of dispersal ability in the tribe Brassiceae (Brassicaceae). | BACKGROUND AND AIMS: Dispersal and establishment ability can influence evolutionary processes such as geographic isolation, adaptive divergence and extinction probability. Through these population-level dynamics, dispersal ability may also influence macro-evolutionary processes such as species distributions and diversi... | ['Bayes Theorem', 'Biodiversity', 'Biological Evolution', 'Brassicaceae', 'Climate', 'Fruit', 'Phylogeny', 'Quantitative Trait, Heritable', 'Seed Dispersal', 'Seeds'] | 25,342,656 | [['E05.318.740.600.200', 'N05.715.360.750.625.150', 'N06.850.520.830.600.200'], ['G16.500.275.157.049', 'N06.230.124.049'], ['G05.045', 'G16.075'], ['B01.650.940.800.575.912.250.157'], ['G16.500.275.071', 'N06.230.300.100.250'], ['A18.024.500', 'G07.203.300.562', 'J02.500.562'], ['G05.697', 'G16.075.605', 'L01.100.697'... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 |
Conformational stability of cytochrome C probed by optical spectroscopy. | Over the last 50 years cytochrome c has been used as a model system for studying electron transfer and protein folding processes. Recently, convincing evidence has been provided that this protein is also involved in other biological processes such as the apoptosis and á-synuclein aggregation. Numerous lines of evidence... | ['Animals', 'Circular Dichroism', 'Cytochromes c', 'Humans', 'Models, Molecular', 'Protein Conformation', 'Protein Stability', 'Spectrophotometry, Atomic'] | 21,609,860 | [['B01.050'], ['E05.196.867.151'], ['D08.244.286.100', 'D12.776.422.220.286.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.595'], ['G02.111.570.820.709'], ['G02.111.700'], ['E05.196.712.726.551', 'E05.196.867.826.551']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Candida shehatae--genetic diversity and phylogenetic relationships with other xylose-fermenting yeasts. | The xylose-fermenting yeasts Candida shehatae and Pichia stipitis were compared from extent of nuclear DNA complementarity and ribosomal RNA sequence similarity. Low levels of DNA relatedness confirmed that the two taxa are distinct biological species, but the similarity of rRNA sequences suggests that they only recent... | ['Base Composition', 'Base Sequence', 'Candida', 'DNA, Fungal', 'Fermentation', 'Genetic Variation', 'Molecular Sequence Data', 'Phylogeny', 'Pichia', 'RNA, Fungal', 'RNA, Ribosomal', 'Saccharomycetales', 'Sequence Homology, Nucleic Acid', 'Xylose'] | 2,353,807 | [['G02.111.080'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['B01.300.107.795.095', 'B01.300.381.147', 'B01.300.930.176'], ['D13.444.308.300'], ['G02.111.158.249', 'G03.191.249'], ['G05.365'], ['L01.453.245.667'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['B01.300.107.795.700', 'B01.300.930.600'], ['... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Educational status and blood pressure: the Second National Health and Nutrition Examination Survey, 1976-1980, and the Hispanic Health and Nutrition Examination Survey, 1982-1984. | An inverse association between socioeconomic status, as measured by years of education, and blood pressure has been reported in a number of studies. However, two secular trends may have changed the nature of this relation: a higher mean level of education in the population and intervention for high blood pressure in th... | ['Adult', 'Age Factors', 'Aged', 'Blood Pressure', 'Body Mass Index', 'Educational Status', 'Ethnic Groups', 'Health Surveys', 'Hispanic Americans', 'Humans', 'Hypertension', 'Linear Models', 'Middle Aged', 'Predictive Value of Tests', 'Social Class', 'United States'] | 1,510,080 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['N01.824.196'], ['M01.686.754', 'N01.224.317'], ['E05.318.308.980.438', 'N05.715.360.300.800.438', 'N0... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Species difference in glutathione level and glutathione related enzyme activities in rats, mice, guinea pigs and hamsters. | Total glutathione (GSH and GSSG) level, and the activities of gamma-glutamylcysteine synthetase, gamma-glutamyltranspeptidase (gamma-GTP), glutathione S-transferase (GST), glutathione peroxidase (GSH-Px) and glutathione reductase (GR) in the liver were investigated in rats, mice, guinea pigs and hamsters. Hepatic GSH l... | ['Animals', 'Bile', 'Cricetinae', 'Fasting', 'Glutamate-Cysteine Ligase', 'Glutathione', 'Glutathione Disulfide', 'Glutathione Peroxidase', 'Glutathione Reductase', 'Glutathione Transferase', 'Guinea Pigs', 'Lipid Peroxides', 'Liver', 'Male', 'Mesocricetus', 'Mice', 'Mice, Inbred ICR', 'Rats', 'Rats, Inbred Strains', '... | 6,143,791 | [['B01.050'], ['A12.200.087'], ['B01.050.150.900.649.313.992.635.075.250'], ['F01.145.407.400', 'G07.203.650.240.587', 'G07.203.650.353.400'], ['D08.811.464.259.850.400'], ['D12.644.456.448'], ['D12.644.456.448.500'], ['D08.811.682.732.500'], ['D08.811.682.667.092'], ['D08.811.913.225.500'], ['B01.050.150.900.649.313.9... | ['Organisms [B]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Establishment of inducible wild type and mutant myocilin-GFP-expressing RGC5 cell lines. | BACKGROUND: Myocilin is a gene linked directly to juvenile- and adult-onset open angle glaucoma. Mutations including Gln368stop (Q368X) and Pro370Leu (P370L) have been identified in patients. The exact role of myocilin and its functional association with glaucoma are still unclear. In the present study, we established ... | ['Actins', 'Animals', 'Blotting, Western', 'Cell Culture Techniques', 'Cell Line', 'Cell Movement', 'Cytoskeletal Proteins', 'Doxycycline', 'Eye Proteins', 'Glycoproteins', 'Green Fluorescent Proteins', 'Humans', 'Mutant Proteins', 'Plasmids', 'Rats', 'Recombinant Fusion Proteins', 'Staining and Labeling', 'Stress Fibe... | 23,082,156 | [['D05.750.078.730.250', 'D12.776.210.500.100', 'D12.776.220.525.255'], ['B01.050'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['E01.370.225.500.223', 'E05.200.500.265', 'E05.242.223', 'E05.481.500.249'], ['A11.251.210'], ['G04.198', 'G07.568.500.180'], ['D12.7... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Intermediate syndrome of platelet dysfunction. | We studied eight patients with intermittent bleeding episodes usually following trauma and associated with the ingestion of medicine known to interfere with platelet function. All patients had a normal or minimally prolonged baseline bleeding time. All had a normal platelet count, glass bead retention test, and platele... | ['Adolescent', 'Adult', 'Aspirin', 'Blood Cell Count', 'Blood Coagulation Tests', 'Blood Platelet Disorders', 'Blood Platelets', 'Child', 'Female', 'Humans', 'Male', 'Platelet Aggregation', 'Platelet Factor 3', 'Serotonin', 'Syndrome'] | 656,620 | [['M01.060.057'], ['M01.060.116'], ['D02.455.426.559.389.657.410.595.176'], ['E01.370.225.500.195.107', 'E01.370.225.625.107', 'E05.200.500.195.107', 'E05.200.625.107', 'E05.242.195.107', 'G04.140.107', 'G09.188.105'], ['E01.370.225.625.115', 'E05.200.625.115'], ['C15.378.140'], ['A11.118.188', 'A15.145.229.188'], ['M0... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Pyrimidine dimer excision in surviving and nonsurviving cells of ultraviolet-irradiated cultures of Escherichia coli. | We compared dimer excision in viable and nonviable cells fractions separated from Escherichia coli B/r cultures exposed to ultraviolet (UV) irradiation. For cells grown on minimal medium with glycerol as a carbon source, both fractions from the irradiated (20 J/m2, 5% survival) culture excised 60 to 70% of the thymine ... | ['DNA Repair', 'DNA, Bacterial', 'Escherichia coli', 'Glucose', 'Glycerol', 'Pyrimidines', 'Radiation Effects', 'Ultraviolet Rays'] | 770,461 | [['G02.111.222', 'G05.219'], ['D13.444.308.212'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D09.947.875.359.448'], ['D02.033.800.875.500', 'D09.853.875.500'], ['D03.383.742'], ['G01.750.745', 'N06.850.810.300'], ['G01.358.500.505.650.891', 'G01.590.540.891', 'G01.750.250.650.891', 'G01.750.750.659', 'G0... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Metformin prevents endotoxin-induced liver injury after partial hepatectomy. | Metformin [2-(N,N-dimethylcarbamimidoyl)guanidine] is a drug used in the treatment of type 2 diabetes. Recent studies have suggested that metformin may have effects in addition to lowering serum glucose concentrations (e.g., anti-inflammatory). The aim of the present study was to determine whether metformin prevents th... | ['Animals', 'Carbohydrate Metabolism', 'Cytokines', 'Hepatectomy', 'Hypoglycemic Agents', 'Inflammation', 'Lipopolysaccharides', 'Liver', 'Male', 'Metformin', 'Plasminogen Activator Inhibitor 1', 'Rats', 'Rats, Sprague-Dawley', 'Urokinase-Type Plasminogen Activator'] | 16,322,356 | [['B01.050'], ['G02.111.158', 'G03.191'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['E04.210.556'], ['D27.505.696.422'], ['C23.550.470'], ['D09.400.500', 'D09.698.718.450', 'D10.494', 'D23.050.161.616.525', 'D23.946.123.329.500'], ['A03.620'], ['D02.078.370.141.450'], ['D12.644.861.695.500', 'D12.776.124.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Current Generation Balloon-Expandable Transcatheter Valve Positioning Strategies During Aortic Valve-in-Valve Procedures and Clinical Outcomes. | OBJECTIVES: This study sought to evaluate SAPIEN 3 (S3) (Edwards Lifesciences, Irvine, California) positioning using different strategies.BACKGROUND: Aortic valve-in-valve (ViV) is associated with high risk of elevated gradients.METHODS: S3 aortic ViV procedures in stented bioprostheses were studied. Transcatheter hear... | ['Aged', 'Aged, 80 and over', 'Aortic Valve', 'Aortic Valve Insufficiency', 'Aortic Valve Stenosis', 'Balloon Valvuloplasty', 'Bioprosthesis', 'Female', 'Heart Valve Prosthesis', 'Heart Valve Prosthesis Implantation', 'Humans', 'Male', 'Prosthesis Design', 'Prosthesis Failure', 'Risk Factors', 'Transcatheter Aortic Val... | 31,439,340 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['A07.541.510.110'], ['C14.280.484.048.500'], ['C14.280.484.048.750', 'C14.280.955.249'], ['E02.148.108', 'E05.157.125'], ['E07.695.100'], ['E07.695.310'], ['E04.100.376.485', 'E04.650.410', 'E04.928.220.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.320.550... | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Gaussian fluctuations and linear response in an electron transfer protein. | In response to charge separation or transfer, polar liquids respond in a simple linear fashion. A similar linear response for proteins might be expected from the central limit theorem and is postulated in widely used theories of protein electrostatics, including the Marcus electron transfer theory and dielectric contin... | ['Computer Simulation', 'Cytochrome c Group', 'Electron Transport', 'Energy Transfer', 'Heme', 'Linear Models', 'Models, Chemical', 'Models, Statistical', 'Normal Distribution', 'Oxidation-Reduction', 'Saccharomyces cerevisiae'] | 12,011,418 | [['L01.224.160'], ['D08.244.286', 'D12.776.422.220.286'], ['G02.111.248', 'G03.295.531.403', 'G03.493.350'], ['G01.154.240', 'G02.111.255', 'G02.216'], ['D03.383.129.578.840.500.640.587', 'D03.633.400.909.500.640.587', 'D04.345.783.500.640.587', 'D23.767.727.640.587'], ['E05.318.740.500.500', 'E05.318.740.750.425', 'E0... | ['Information Science [L]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Cigarette smoke impacts immune inflammatory responses to influenza in mice. | RATIONALE: Studies have shown that cigarette smoke impacts respiratory host defense mechanisms; however, it is poorly understood how these smoke-induced changes impact the overall ability of the host to deal with pathogenic agents.OBJECTIVE: The objective of this study was to investigate the impact of mainstream cigare... | ['Animals', 'Female', 'Flow Cytometry', 'Inflammation', 'Influenza A virus', 'Interleukin-6', 'Mice', 'Mice, Inbred C57BL', 'Orthomyxoviridae Infections', 'Peroxidase', 'Smoking', 'Tumor Necrosis Factor-alpha', 'Viral Load'] | 17,023,734 | [['B01.050'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.200.500.386.350', 'E05.242.363.342', 'E05.242.386.350'], ['C23.550.470'], ['B04.820.480.968.405.400'], ['D12.644.276.374.465.224', 'D12.776.467.374.465.202', 'D23.529.374.465.224'], ['B01.050.... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[A case report of advanced gastric cancer remarkably responding to mitomycin C, aclacinomycin A, SF-SP and lentinan combination therapy]. | A 63-year-old female diagnosed as inoperable gastric cancer was treated with combination immunochemotherapy of Mitomycin C, Aclacinomycin A, SF-SP and Lentinan. In this case, the tumor directly invaded the pancreas and the peritoneal dissemination, metastasis to the para-aortic lymph nodes and Virchow's metastasis were... | ['Aclarubicin', 'Antineoplastic Combined Chemotherapy Protocols', 'Female', 'Humans', 'Immunotherapy', 'Lentinan', 'Middle Aged', 'Mitomycin', 'Mitomycins', 'Polysaccharides', 'Stomach Neoplasms', 'Tegafur'] | 2,105,085 | [['D02.455.426.559.847.562.050.050', 'D04.615.562.050.050', 'D09.408.051.059.050'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.095.465.425'], ['D09.698.365.089.500'], ['M01.060.116.630'], ['D02.806.400.249.350', 'D03.383.097.500.350', 'D03.633.100.4... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Heterotopic ossification after femoral intramedullary rodding. | Heterotopic ossification (HO) after femoral intramedullary rodding is a significant complication of the procedure. One hundred eighteen cases of femoral roddings performed on 113 patients were available for review. The data were computerized and evaluated using univariate analysis and multivariate regression analysis. ... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Craniocerebral Trauma', 'Female', 'Femoral Fractures', 'Fracture Fixation, Intramedullary', 'Humans', 'Injury Severity Score', 'Male', 'Middle Aged', 'Ossification, Heterotopic', 'Retrospective Studies', 'Risk Factors'] | 8,308,607 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C10.900.300', 'C26.915.300'], ['C26.404.061', 'C26.558.276'], ['E04.555.300.300.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.940.968.875.500', 'E05.944.600', 'N04.452.859.564.800.500', 'N05.715.360.300.715.500.80... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Choline acetyltransferase in cerebral arteries: modulator of amino acid uptake? | The possibility exists that synthesis of acetylcholine in cerebral blood vessels does not reflect the presence of cholinergic nerves, but is the property of some other cell type. Therefore, the hypothesis that acetylcholine synthesis in cerebral arteries modulates amino acid transport was tested. Choline acetyltransfer... | ['Acetylcholine', 'Amino Acids', 'Aminoisobutyric Acids', 'Animals', 'Biological Transport', 'Blood-Brain Barrier', 'Cerebral Arteries', 'Choline O-Acetyltransferase', 'Female', 'In Vitro Techniques', 'Male', 'Ouabain', 'Rabbits'] | 7,143,235 | [['D02.092.211.111'], ['D12.125'], ['D02.241.081.114.968.249', 'D12.125.070.075', 'D12.125.190.055'], ['B01.050'], ['G03.143'], ['A07.035', 'A08.186.211.035'], ['A07.015.114.228'], ['D08.811.913.050.134.180'], ['E05.481'], ['D04.210.500.155.580.130.750.600', 'D09.408.180.810.600'], ['B01.050.150.900.649.313.968.700']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Frequent issues and lessons learned from EuroFlow QA. | EuroFlow Quality Assessment was designed to provide a feedback on the quality of the standardization effort in executing the EuroFlow protocols for sample preparation and instrument setup. It was first beta-tested by the members of the EuroFlow consortium internally (2010-2013) and opened to the external participants f... | ['Flow Cytometry', 'Humans', 'Laboratories', 'Laboratory Proficiency Testing', 'Reference Standards'] | 30,237,053 | [['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.200.500.386.350', 'E05.242.363.342', 'E05.242.386.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['J03.520', 'N02.278.487'], ['J01.897.608.500', 'N04.761.700.512'], ['E05.978.808']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
[Basal cell nevus syndrome. Presentation of 2 cases. 1 associated with medulloblastoma]. | A case of nevoid basal-cell carcinoma syndrome in a four years old girl with preceding familiar history is reported. In her epithelioma father numerous basocellular, milia cysts, mandibular cysts, dentition disorders, brain falx calcifica ted and hiperkeratosis of the sole of the feet were described. Clinically, the gi... | ['Abnormalities, Multiple', 'Adult', 'Basal Cell Nevus Syndrome', 'Carcinoma, Basal Cell', 'Cerebellar Neoplasms', 'Child, Preschool', 'Cysts', 'Female', 'Humans', 'Male', 'Mandibular Diseases', 'Medulloblastoma', 'Neoplasms, Multiple Primary', 'Skin Neoplasms'] | 3,887,060 | [['C16.131.077'], ['M01.060.116'], ['C04.182.089.530.690.150', 'C04.557.470.200.165.150', 'C04.557.470.565.165.150', 'C04.700.175', 'C05.116.099.105', 'C05.500.470.690.150', 'C07.320.450.670.130', 'C16.131.077.130', 'C16.320.700.175'], ['C04.557.470.200.165', 'C04.557.470.565.165'], ['C04.588.614.250.195.411.211', 'C10... | ['Diseases [C]', 'Named Groups [M]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Colorectal flat neoplasia. | BACKGROUND AND AIMS: An attempt has been made to evaluate the clinicopathological characteristics of flat colorectal neoplastic lesions, and analyse the factors associated with the malignancy.PATIENTS AND METHODS: A total of 115 flat neoplastic lesions, > or = 5 mm in size, diagnosed in 87 patients by colonoscopy, were... | ['Adenocarcinoma', 'Adenoma', 'Adult', 'Aged', 'Colonoscopy', 'Colorectal Neoplasms', 'Female', 'Humans', 'Male', 'Middle Aged', 'Rectum', 'Risk Factors'] | 12,779,070 | [['C04.557.470.200.025'], ['C04.557.470.035'], ['M01.060.116'], ['M01.060.116.100'], ['E01.370.372.250.250.200', 'E01.370.388.250.250.250.160', 'E04.210.240.250.160', 'E04.502.250.250.250.160'], ['C04.588.274.476.411.307', 'C06.301.371.411.307', 'C06.405.249.411.307', 'C06.405.469.158.356', 'C06.405.469.491.307', 'C06.... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Fatigue models as practical tools: diagnostic accuracy and decision thresholds. | Human fatigue models are increasingly being used in a variety of industrial settings, both civilian and military. Current uses include education, awareness, and analysis of individual or group work schedules. Perhaps the ultimate and potentially most beneficial use of human fatigue models is to diagnose if an individua... | ['Decision Support Techniques', 'Fatigue', 'Humans', 'Industry', 'Models, Biological', 'Reproducibility of Results', 'Risk Assessment', 'Safety', 'Sensitivity and Specificity', 'Signal Detection, Psychological', 'Work Capacity Evaluation', 'Work Schedule Tolerance'] | 15,018,281 | [['E05.245', 'L01.313.500.750.190'], ['C23.888.369'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['J01.576'], ['E05.599.395'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['E05.318.740.600.800.715', 'N04.452.871.715', 'N05.715.360.750.625.700.690', 'N06.850.505.715', 'N06.850... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Diseases [C]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [... | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 |
Radiotherapy treatment planning for patients fitted with prostheses. | The effects of prostheses on radiotherapy treatment planning are discussed. The compositions of commonly used materials are tabulated. Sample plots show the size of perturbations produced by typical absorbers at 8 MV. A technique for estimating the density of a prosthesis in a patient is demonstrated and the effects of... | ['Alloys', 'Humans', 'Models, Structural', 'Prostheses and Implants', 'Radiotherapy', 'Radiotherapy Dosage'] | 6,733,406 | [['D01.552.033', 'D25.058', 'J01.637.051.058'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['J01.897.280.500.545', 'L01.178.820.090.545'], ['E07.695'], ['E02.815'], ['E02.815.639']] | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Psychometric properties of the Intrinsic Motivation Inventory in a competitive sport setting: a confirmatory factor analysis. | The present study was designed to assess selected psychometric properties of the Intrinsic Motivation Inventory (IMI) (Ryan, 1982), a multidimensional measure of subjects' experience with regard to experimental tasks. Subjects (N = 116) competed in a basketball free-throw shooting game, following which they completed t... | ['Adult', 'Basketball', 'Chi-Square Distribution', 'Competitive Behavior', 'Factor Analysis, Statistical', 'Female', 'Humans', 'Male', 'Motivation', 'Psychological Tests', 'Psychometrics'] | 2,489,825 | [['M01.060.116'], ['I03.450.642.845.117'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['F01.145.813.105'], ['E05.318.740.400', 'N05.715.360.750.350', 'N06.850.520.830.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.658', 'F01.752.543.500.750'], ['F04.711'... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Imprint switching on human chromosome 15 may involve alternative transcripts of the SNRPN gene. | Imprinting on human chromosome 15 is regulated by an imprinting centre, which has been mapped to a 100-kb region including exon 1 of SNRPN. From this region we have identified novel transcripts, which represent alternative transcripts of the SNRPN gene. The novel exons lack protein coding potential and are expressed fr... | ['Alternative Splicing', 'Angelman Syndrome', 'Autoantigens', 'Base Sequence', 'Chromosome Mapping', 'Chromosomes, Human, Pair 15', 'DNA Methylation', 'Exons', 'Female', 'Gene Expression Regulation, Developmental', 'Genes', 'Genes, Switch', 'Genomic Imprinting', 'Humans', 'Male', 'Molecular Sequence Data', 'Organ Speci... | 8,841,186 | [['G02.111.760.700.100', 'G03.839.700.100', 'G05.308.700.700.100'], ['C10.228.662.075', 'C16.131.077.095', 'C16.131.260.040', 'C16.320.180.040'], ['D23.050.422'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.393.183'], ['A11.284.187.520.300.370.385', 'G05.360.162.520.300.370.385'], ['G02.111.035.538... | ['Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Anti-Ischemic Activity of Fabomotizole Hydrochloride under Conditions of Endothelial Dysfunction. | Anti-ischemic activity of fabomotizole hydrochloride was studied on the model of subendocardial ischemia in rats with endothelial dysfunction. Endothelial dysfunction was modeled by intragastric administration of methionine (3 g/kg, once a day for 7 days). Acute subendocardial ischemia was induced in narcotized rats by... | ['Animals', 'Animals, Outbred Strains', 'Benzimidazoles', 'Cardiotonic Agents', 'Disease Models, Animal', 'Endocardium', 'Endothelium, Vascular', 'Isoproterenol', 'Male', 'Methionine', 'Morpholines', 'Myocardial Ischemia', 'Rats', 'Treatment Outcome'] | 31,705,224 | [['B01.050'], ['B01.050.050.284'], ['D03.633.100.103'], ['D27.505.954.411.222', 'D27.720.799.080'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['A07.541.207'], ['A07.015.700.500', 'A10.272.491.355'], ['D02.033.100.291.439', 'D02.092.063.291.439', 'D02.092.311.649', 'D02.455.426.559.389.657.166.175.649'], ['D02.886.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Effects of cryopreservation methods on post-thaw motility of spermatozoa from the Japanese pearl oyster, Pinctada fucata martensii. | In order to develop cryopreservation techniques for Japanese pearl oyster spermatozoa, the effects of various cryopreservation conditions on post-thaw motility were examined. Spermatozoa cryopreserved with 10% methanol (MET), dimethylformamide or dimethylacetamide plus 90% diluent comprising 80% seawater and 20% fetal ... | ['Animals', 'Cryopreservation', 'Cryoprotective Agents', 'Male', 'Pinctada', 'Semen Preservation', 'Sperm Motility', 'Spermatozoa', 'Temperature', 'Time Factors'] | 17,174,293 | [['B01.050'], ['E01.370.225.500.620.760.160', 'E01.370.225.750.600.760.160', 'E02.792.156', 'E05.200.500.620.760.160', 'E05.200.750.600.760.160', 'E05.760.156'], ['D27.505.696.706.320', 'D27.720.799.180'], ['B01.050.500.644.080.670'], ['E02.792.833.890', 'E05.760.833.890'], ['E01.370.225.992.812', 'E05.200.992.812', 'G... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Regional regulation of choroidal blood flow by autonomic innervation in the rat. | Regional influences of parasympathetic and sympathetic innervation on choroidal blood flow were investigated in anesthetized rats. Parasympathetic pterygopalatine neurons were activated by electrically stimulating the superior salivatory nucleus, whereas sympathetic neurons were activated by cervical sympathetic trunk ... | ['Adrenergic alpha-Antagonists', 'Animals', 'Atropine', 'Autonomic Pathways', 'Blood Pressure', 'Choroid', 'Electric Stimulation', 'Female', 'Imidazoles', 'Laser-Doppler Flowmetry', 'Mydriatics', 'Nitric Oxide Synthase', 'Nitric Oxide Synthase Type I', 'Parasympathetic Nervous System', 'Prazosin', 'Rats', 'Rats, Spragu... | 10,896,883 | [['D27.505.519.625.050.200.100', 'D27.505.696.577.050.200.100'], ['B01.050'], ['D02.145.074.722.229.199', 'D03.132.760.180.572.199', 'D03.132.889.180.648.199', 'D03.605.084.500.722.229.199', 'D03.605.869.229.199'], ['A08.800.050.050', 'A08.800.800.060'], ['E01.370.600.875.249', 'G09.330.380.076'], ['A09.371.894.223'], ... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Evaluating the potential of chelation therapy to prevent and treat gadolinium deposition from MRI contrast agents. | Several MRI contrast agent clinical formulations are now known to leave deposits of the heavy metal gadolinium in the brain, bones, and other organs of patients. This persistent biological accumulation of gadolinium has been recently recognized as a deleterious outcome in patients administered Gd-based contrast agents ... | ['Animals', 'Chelating Agents', 'Chelation Therapy', 'Contrast Media', 'Disease Models, Animal', 'Gadolinium', 'Humans', 'Magnetic Resonance Imaging', 'Metabolic Diseases', 'Mice', 'Treatment Outcome'] | 29,535,330 | [['B01.050'], ['D27.505.519.914.500', 'D27.720.832.500'], ['E02.319.155'], ['D27.505.259.500', 'D27.720.259'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['D01.268.558.362.484', 'D01.552.550.399.484'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['C18.452'], ['B01.050.150.900.649.313.9... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[Extensive pulmonary embolism secondary to varicophlebitis]. | Varicophlebitis is a common disease in the medical practice of dermatologists and phlebologists. In contrast to deep vein thrombosis, which is often associated with pulmonary embolism or other secondary complications, varicophlebitis usually has an uncomplicated course. We present the unusual case of a woman who develo... | ['Aged', 'Female', 'Humans', 'Phlebitis', 'Pulmonary Embolism', 'Ultrasonography, Doppler, Duplex', 'Varicose Veins'] | 21,057,915 | [['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.617.718', 'C14.907.940.740'], ['C08.381.746', 'C14.907.355.350.700'], ['E01.370.350.850.850.850'], ['C14.907.927']] | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Comparative evaluation of brain neurometabolites and DTI indices following whole body and cranial irradiation: a magnetic resonance imaging and spectroscopy study. | Understanding early differential response of brain during whole body radiation or cranial radiation exposure is of significant importance for better injury management during accidental or intentional exposure to ionizing radiation. We investigated the early microstructural and metabolic profiles using in vivo diffusion... | ['Animals', 'Anisotropy', 'Brain', 'Cranial Irradiation', 'Diffusion Tensor Imaging', 'Magnetic Resonance Imaging', 'Magnetic Resonance Spectroscopy', 'Male', 'Mice', 'Time Factors', 'Whole-Body Irradiation'] | 24,038,203 | [['B01.050'], ['G01.590.040', 'G02.050'], ['A08.186.211'], ['E02.815.190'], ['E01.370.350.578.750', 'E01.370.350.825.500.150.500', 'E01.370.376.537.500', 'E05.629.750'], ['E01.370.350.825.500'], ['E05.196.867.519'], ['B01.050.150.900.649.313.992.635.505.500'], ['G01.910.857'], ['E02.815.814', 'E05.980']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Johne's disease: a successful eradication programme in a dairy goat herd. | This retrospective analysis and report describes the successful eradication and posteradication surveillance programme for Johne's disease (Mycobacterium avium subspecies paratuberculosis (MAP)) in a closed herd of dairy goats. In 1994, MAP's presence in the goat herd was first suspected through individual annual serol... | ['Animals', 'Dairying', 'Disease Eradication', 'Feces', 'Female', 'Goat Diseases', 'Goats', 'Mycobacterium avium subsp. paratuberculosis', 'New Zealand', 'Paratuberculosis', 'Program Evaluation', 'Retrospective Studies'] | 29,431,145 | [['B01.050'], ['J01.040.246'], ['N06.850.275'], ['A12.459'], ['C22.405'], ['B01.050.150.900.649.313.500.380.513'], ['B03.510.024.962.500.300.600', 'B03.510.460.400.410.552.552.300.600'], ['Z01.639.760.747', 'Z01.678.100.747'], ['C01.150.252.410.040.552.475.747', 'C22.688'], ['E05.337.820', 'N04.761.685', 'N05.715.360.6... | ['Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Anatomy [A]', 'Diseases [C]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
Characterization of an expressed CD3-associated Ti gamma-chain reveals C gamma domain polymorphism. | The majority of human T cells express an antigen receptor consisting of a disulphide-linked heterodimer (Ti) of relative molecular mass 80,000-90,000 (Mr 80-90K) which is noncovalently associated with a set of at least three proteins of Mr 20-28K termed CD3 (Leu4, T3). Whereas both chains of Ti, an acidic alpha-chain o... | ['Antigens, Differentiation, T-Lymphocyte', 'Antigens, Surface', 'Base Sequence', 'Cell Line', 'DNA', 'Humans', 'Molecular Weight', 'Polymorphism, Genetic', 'Receptors, Antigen, T-Cell', 'Repetitive Sequences, Nucleic Acid', 'T-Lymphocytes'] | 3,102,973 | [['D23.050.301.264.894', 'D23.101.100.894'], ['D23.050.301'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A11.251.210'], ['D13.444.308'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.494'], ['G05.365.795'], ['D12.776.543.750.705.816.824'], ['G02.111.570.080.708', 'G05.360.080.708'], ['A11.118... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Long-term survival in a rodent model of disseminated brain tumors by combined intrathecal delivery of herpes vectors and ganciclovir treatment. | Brain tumors that have disseminated into cerebrospinal fluid (CSF) pathways are an unresolved therapeutic problem, especially in pediatric neurooncology. Here a gene therapy approach using the herpes simplex virus type 1 thymidine kinase (HSV-TK)/ganciclovir (GCV) paradigm was tested using an HSV vector in a rodent mod... | ['Animals', 'Antiviral Agents', 'Brain Neoplasms', 'Disease Models, Animal', 'Ganciclovir', 'Genetic Vectors', 'Gliosarcoma', 'Herpesvirus 1, Human', 'Humans', 'Injections, Spinal', 'Neoplasms, Experimental', 'Rats', 'Thymidine Kinase', 'Time Factors', 'Tumor Cells, Cultured'] | 8,930,659 | [['B01.050'], ['D27.505.954.122.388'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['D03.633.100.759.758.399.454.250.300'], ['G05.360.337'], ['C04.557.465.625.600.380.400', 'C04.557.470.670.380.400', 'C04.557.580.625.600.380.400'], ['B04.280.382.100.750.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Analysis begins in the analyst's mind: conceptual and technical considerations on recommending analysis. | For certain patients who approach analysts for treatment, analysis remains the only treatment that can provide the urgent and at times lifesaving help they need. At the same time, recommending analysis presents analysts with a surprisingly challenging emotional task. Because patients will not be able to get analytic he... | ['Humans', 'Professional-Patient Relations', 'Psychoanalytic Therapy', 'Transference, Psychology', 'Unconscious, Psychology'] | 24,234,982 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.401.650', 'N05.300.660'], ['F04.754.709'], ['F04.754.720.864'], ['F01.752.747.930', 'F02.739.794.942']] | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[MITRAL VALVE REPAIR WITH MINIMALLY INVASIVE CARDIAC SURGERY APPROACH AS ROUTINE PRACTICE]. | Although minimally invasive cardiac surgery (MICS) via right minithoracotomy is attracting attention as a minimally invasive approach in cardiac surgery, it has not become a standard, routine approach for mitral valve repair. Although it has spread rapidly in Germany (43%) and USA (20.4%), the proportion of MICS in iso... | ['Cardiac Surgical Procedures', 'Heart Valve Diseases', 'Heart Valve Prosthesis', 'Humans', 'Minimally Invasive Surgical Procedures', 'Mitral Valve'] | 27,295,774 | [['E04.100.376', 'E04.928.220'], ['C14.280.484'], ['E07.695.310'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.502'], ['A07.541.510.507']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Regulation of G-protein-coupled receptors]. | G protein coupled receptors are the largest family of receptors in the organism. When the transmitter input is significantly changed in comparison to normal condition, the homologous or heterologous regulation can occur. Homologous regulation represents the situation in which the properties of the receptor system just ... | ['GTP-Binding Protein Regulators', 'GTP-Binding Proteins', 'Receptors, Cell Surface', 'Signal Transduction'] | 12,693,184 | [['D12.644.360.325', 'D12.776.476.325'], ['D08.811.277.040.330.300', 'D12.776.157.325'], ['D12.776.543.750'], ['G02.111.820', 'G04.835']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The preparation of additional smears from a cervical scrape: impact on the rate of detection of cervical neoplasia. | The preparation of additional smears from a cervical scrape: impact on the rate of detection of cervical neoplasia It has been known for some time that only a proportion of the cells on the smear-taking device is transferred to the slide. This can give rise to errors in reporting although the smear may have been taken ... | ['Adult', 'Biopsy', 'Cell Count', 'Female', 'Humans', 'Middle Aged', 'Papanicolaou Test', 'Predictive Value of Tests', 'Reproducibility of Results', 'Uterine Cervical Dysplasia', 'Uterine Cervical Neoplasms', 'Vaginal Smears'] | 11,380,556 | [['M01.060.116'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['E01.370.225.500.195', 'E05.200.500.195', 'E05.242.195', 'G04.140'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.370.225.500.3... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
An interview with Deepak Srivastava. | Deepak Srivastava is a Director at the Gladstone Institute of Cardiovascular Disease and a Distinguished Professor in Paediatric Developmental Cardiology at the University of California, San Francisco. As well as caring for sick children as a physician at the Benioff Children's Hospital in San Francisco, he runs an act... | ['Cardiology', 'Cardiovascular Diseases', 'Career Choice', 'Humans', 'Pediatrics', 'San Francisco', 'Translational Medical Research'] | 26,081,568 | [['H02.403.429.163'], ['C14'], ['F02.463.785.373.346.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H02.403.670'], ['Z01.107.567.875.580.200.700', 'Z01.107.567.875.760.200.700', 'Z01.433.875'], ['H01.770.644.145.675']] | ['Disciplines and Occupations [H]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 |
Studies on the sub-banding of creatine kinase MM and the "CK conversion factor". | In serum, the M subunit of creatine kinase (CK) isoenzymes, MM and MB, is modified by a heat labile factor. As a result of the modification three sub-bands of MM and two of MB can be demonstrated by agarose electrophoresis. Normal sera contain MM1 as the dominant sub-band with lesser amounts of MM2 and MM3. Following t... | ['Biological Products', 'Chromatography, Ion Exchange', 'Coronary Artery Bypass', 'Creatine Kinase', 'Electrophoresis, Agar Gel', 'Humans', 'Isoenzymes', 'Molecular Weight', 'Myocardium'] | 6,972,275 | [['D20.215'], ['E05.196.181.400.383'], ['E04.100.376.719.332', 'E04.100.814.868.750', 'E04.928.220.520.220'], ['D08.811.913.696.640.150'], ['E05.196.401.153', 'E05.301.300.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.348', 'D12.776.800.300'], ['G02.494'], ['A02.633.580', 'A07.541.704', 'A10.690.552... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
HLA and ragweed allergy. | In summary, two large families were subjected to genetic analysis of the distribution of the immune response. S linkage analysis indicated that this locus for positive skin test reaction to antigen E and/or personal history or seasonal allergy is linked to HLA-B. The maximum likelihood estimate of the recombination fre... | ['Cytotoxicity Tests, Immunologic', 'Female', 'Gene Frequency', 'Genes', 'Genetic Linkage', 'HLA Antigens', 'Histocompatibility Antigens', 'Humans', 'Male', 'Pedigree', 'Pollen', 'Recombination, Genetic', 'Rhinitis, Allergic, Seasonal'] | 876,131 | [['E01.370.225.812.160', 'E05.200.812.160', 'E05.478.594.160', 'E05.940.245'], ['G05.330'], ['G05.360.340.024.340'], ['G05.348'], ['D23.050.301.500.450', 'D23.050.705.552.450'], ['D23.050.301.500', 'D23.050.705.552'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.393.673'], ['A18.024.249.500.249.500'], ['G05.7... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Hymenolepis diminuta-induced fecundity reduction may be caused by changes in hormone binding to Tenebrio molitor ovaries. | Aspects of vitellogenesis, known to be controlled by juvenile hormone, are adversely affected by Hymenolepis diminuta infection of Tenebrio molitor, in spite of circulating titres of the hormone remaining unchanged. It has therefore been proposed that juvenile hormone binding is disrupted at the tissue site level. Juve... | ['Animals', 'Biomarkers', 'Cell Nucleus', 'Cytoplasm', 'Data Interpretation, Statistical', 'Female', 'Hymenolepiasis', 'Juvenile Hormones', 'Microsomes', 'Ovary', 'Sesquiterpenes', 'Subcellular Fractions', 'Tenebrio'] | 7,596,640 | [['B01.050'], ['D23.101'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['A11.284.430.214'], ['E05.245.380', 'E05.318.740.300', 'L01.313.500.750.190.380', 'N05.715.360.750.300', 'N06.850.520.830.300'], ['C01.610.335.190.519'], ['D06.472.445.573.666'], ['A11.284.835.540'], ['A05.360.319.114.630', 'A05.360.576.497... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Bing-Neel syndrome - Bilateral cavernous sinus lymphoma causing visual failure. | We report the case of a 68-year-old male with right eye vision loss secondary to a compressive optic neuropathy from Waldenstrom macroglobulinaemia relapse in both cavernous sinuses. Central nervous system involvement is extremely uncommon in lymphoplasmacytic lymphoma. Known as Bing-Neel syndrome, this has not been pr... | ['Aged', 'Blindness', 'Brain Diseases', 'Cavernous Sinus', 'Humans', 'Male', 'Optic Nerve', 'Syndrome', 'Waldenstrom Macroglobulinemia'] | 28,765,059 | [['M01.060.116.100'], ['C10.597.751.941.162', 'C11.966.075', 'C23.888.592.763.941.162'], ['C10.228.140'], ['A07.015.908.224.334'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A08.800.800.120.680'], ['C23.550.288.500'], ['C04.557.595.925', 'C14.907.454.960', 'C15.378.147.780.925', 'C15.378.463.515.960', 'C15.604.... | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The involvement of histone methylation in osteoblastic differentiation of human periosteum-derived cells cultured in vitro under hypoxic conditions. | Although oxygen concentrations affect the growth and function of mesenchymal stem cells (MSCs), the impact of hypoxia on osteoblastic differentiation is not understood. Likewise, the effect of hypoxia-induced epigenetic changes on osteoblastic differentiation of MSCs is unknown. The aim of this study was to examine the... | ['Apoptosis', 'Bone Morphogenetic Protein 2', 'Cell Differentiation', 'Cell Hypoxia', 'Cell Proliferation', 'Cell Survival', 'Cells, Cultured', 'Cellular Senescence', 'Core Binding Factor Alpha 1 Subunit', 'Histones', 'Humans', 'Hypoxia-Inducible Factor 1, alpha Subunit', 'Jumonji Domain-Containing Histone Demethylases... | 29,082,591 | [['G04.146.954.035'], ['D12.644.276.954.200.200', 'D12.776.467.942.200.200', 'D23.529.942.200.200'], ['G04.152'], ['G03.197.300', 'G04.270.300'], ['G04.161.750', 'G07.345.249.410.750'], ['G04.346'], ['A11.251'], ['G04.043'], ['D12.776.930.155.200.100'], ['D12.776.157.687.485', 'D12.776.660.720.485', 'D12.776.664.469'],... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A novel passive dosing system for determining the toxicity of phenanthrene to early life stages of zebrafish. | Reliable experimental early life stage chronic toxicity data for fish are limited and further data are needed for polyaromatic hydrocarbons to establish environmental quality objectives and compare with toxicity model predictions. Efforts are underway to develop a zebrafish embryo toxicity test guideline to reduce, ref... | ['Animals', 'Dose-Response Relationship, Drug', 'Phenanthrenes', 'Toxicity Tests', 'Water', 'Water Pollutants, Chemical', 'Zebrafish'] | 23,872,248 | [['B01.050'], ['G07.690.773.875', 'G07.690.936.500'], ['D02.455.426.559.847.723', 'D04.615.723'], ['E05.940'], ['D01.045.250.875', 'D01.248.497.158.459.650', 'D01.650.550.925'], ['D27.888.284.903.655'], ['B01.050.150.900.493.200.244.828']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Sweet's syndrome in prostate cancer. | Originally described in 1964 as an idiopathic dermatosis occurring in women, Sweet's syndrome (acute febrile neutrophilic dermatosis) is associated with malignancy, typically haematological. We report a case occurring in a man receiving radical radiotherapy for locally advanced prostate cancer. To our knowledge, prosta... | ['Combined Modality Therapy', 'Humans', 'Male', 'Middle Aged', 'Neoplasm Staging', 'Prostate-Specific Antigen', 'Prostatic Neoplasms', 'Sweet Syndrome'] | 18,227,857 | [['E02.186'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.789.625'], ['D08.811.277.656.300.760.442.750', 'D08.811.277.656.959.350.442.750', 'D12.776.866.249.500', 'D23.050.285.625', 'D23.101.140.625'], ['C04.588.945.440.770', 'C12.294.260.750', 'C12.294.565.625', 'C12.758.409.750'], ['C1... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The cell junction protein VAB-9 regulates adhesion and epidermal morphology in C. elegans. | Epithelial cell junctions are essential for cell polarity, adhesion and morphogenesis. We have analysed VAB-9, a cell junction protein in Caenorhabditis elegans. VAB-9 is a predicted four-pass integral membrane protein that has greatest similarity to BCMP1 (brain cell membrane protein 1, a member of the PMP22/EMP/Claud... | ['Actin Cytoskeleton', 'Adherens Junctions', 'Animals', 'Cadherins', 'Caenorhabditis elegans', 'Caenorhabditis elegans Proteins', 'Cell Adhesion', 'Cell Size', 'Claudin-1', 'Cytoskeletal Proteins', 'DNA, Complementary', 'Epidermis', 'Epithelial Cells', 'Intercellular Junctions', 'Membrane Proteins', 'Microscopy, Electr... | 12,819,787 | [['A11.284.430.214.190.750.050'], ['A11.284.149.165.420.020'], ['B01.050'], ['D12.776.395.550.200.200', 'D12.776.543.550.200.200', 'D23.050.301.350.200'], ['B01.050.500.500.294.400.875.660.250.250'], ['D12.776.419.500'], ['G04.022'], ['G04.325'], ['D12.776.543.940.200.100'], ['D12.776.220'], ['D13.444.308.497.220', 'D1... | ['Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
The comparison of the negative effect of autoclaving and pasteurization on bone healing. | OBJECTIVES: The aim of this study was to compare the effects of autoclaving and pasteurization on bone healing.METHODS: Twenty-five full-grown male rabbits were included in the study; all 25 had bone blocks resected and reimplanted. In group 1, bone blocks were autoclaved; in group 2, bone blocks were pasteurized; and ... | ['Animals', 'Bone Regeneration', 'Bone Transplantation', 'Hot Temperature', 'Male', 'Models, Animal', 'Osteotomy', 'Rabbits', 'Radiography', 'Sterilization', 'Transplantation, Homologous', 'Ulna', 'Wound Healing'] | 21,252,610 | [['B01.050'], ['G11.427.213.140', 'G16.762.150.150'], ['E02.095.147.725.052', 'E04.555.130', 'E04.936.580.052'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.775.710.380', 'N06.230.300.100.725.232', 'N06.230.300.100.725.710.380'], ['E05.598'], ['E04.555.580'], ['B01.050.150.900.649.313.968.700'], ['E... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Early graft thrombosis after endovascular aortic aneurysm repair with aortouni-iliac endografts. | Endovascular repair of aortic aneurysm has become a viable treatment option in selected patients. However, despite the minimally invasive nature ot this treatment a significant incidence of vascular complications has been reported. Here, we report two cases of acute limbs ischemia due to endograft thrombosis in patient... | ['Aged', 'Angioplasty', 'Aorta', 'Aortic Aneurysm, Abdominal', 'Aortography', 'Blood Vessel Prosthesis Implantation', 'Follow-Up Studies', 'Graft Occlusion, Vascular', 'Humans', 'Iliac Artery', 'Ischemia', 'Lower Extremity', 'Male', 'Patient Selection', 'Risk Factors', 'Thrombosis', 'Time Factors', 'Treatment Outcome'] | 17,043,613 | [['M01.060.116.100'], ['E02.148.050', 'E04.100.814.529.124', 'E04.502.382.124', 'E05.157.016'], ['A07.015.114.056'], ['C14.907.055.239.075', 'C14.907.109.139.075'], ['E01.370.350.700.060.070', 'E01.370.370.050.070'], ['E04.100.814.868.500', 'E04.650.200'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Assessing fishing and marine biodiversity changes using fishers' perceptions: the Spanish Mediterranean and Gulf of Cadiz case study. | BACKGROUND: The expansion of fishing activities has intensively transformed marine ecosystems worldwide. However, available time series do not frequently cover historical periods.METHODOLOGY: Fishers' perceptions were used to complement data and characterise changes in fishing activity and exploited ecosystems in the S... | ['Adult', 'Aged', 'Analysis of Variance', 'Animals', 'Atlantic Ocean', 'Biodiversity', 'Climate Change', 'Conservation of Natural Resources', 'Ecosystem', 'Fisheries', 'Fishes', 'Geography', 'Humans', 'Mediterranean Sea', 'Middle Aged', 'Perception', 'Population Density', 'Population Dynamics', 'Seawater', 'Spain', 'Su... | 24,465,644 | [['M01.060.116'], ['M01.060.116.100'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['B01.050'], ['Z01.756.092'], ['G16.500.275.157.049', 'N06.230.124.049'], ['G16.500.175.374'], ['J01.256', 'N06.230.080'], ['G16.500.275.157', 'N06.230.124'], ['J01.040.168.300', 'J03.540.280'], ['B01.050.150.900.4... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Disciplines and Occupations [H]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, ... | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
Determination and interpretation of total and transversal linear efficiencies in push-pull ventilation systems for open surface tanks. | A real-scale pilot installation simulating an open surface treatment tank with a push-pull ventilation system has been designed. From experiments carried out, typical representations of the total and transversal linear efficiencies show that when total efficiency is related to push flow rate, taking as a parameter the ... | ['Air Pollutants, Occupational', 'Gas Scavengers', 'Humans', 'Models, Theoretical', 'Occupational Exposure', 'Ventilation'] | 12,270,887 | [['D27.888.284.101.268'], ['E07.427'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599'], ['N06.850.460.350.600'], ['N06.230.150.520']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Voluntary- and Involuntary-Distraction Engagement: An Exploratory Study of Individual Differences. | Objective The aim of this study was to explore individual differences in voluntary and involuntary driver-distraction engagement. Background Distractions may stem from intentional engagement in secondary tasks (voluntary) or failing to suppress non-driving-related stimuli or information (involuntary). A wealth of liter... | ['Adult', 'Attention', 'Distracted Driving', 'Female', 'Humans', 'Individuality', 'Male', 'Psychomotor Performance'] | 29,489,421 | [['M01.060.116'], ['F02.830.104.214'], ['I03.125.474'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.752.488'], ['F02.808', 'G11.427.700', 'G11.561.660']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Respiratory and abdominal muscle responses to expiratory threshold loading in cystic fibrosis. | We hypothesized that the hyperinflation and pulmonary dysfunction of cystic fibrosis (CF) would distort feedback and therefore alter the abdominal muscle response to graded expiratory threshold loads (ETLs). We compared the respiratory and abdominal muscle responses with graded ETLs of seven CF patients with severe lun... | ['Abdominal Muscles', 'Adolescent', 'Adult', 'Cystic Fibrosis', 'Electromyography', 'Feedback', 'Functional Residual Capacity', 'Humans', 'Lung Diseases, Obstructive', 'Posture', 'Respiratory Mechanics', 'Respiratory Muscles', 'Tidal Volume'] | 1,533,213 | [['A02.633.567.050'], ['M01.060.057'], ['M01.060.116'], ['C06.689.202', 'C08.381.187', 'C16.320.190', 'C16.614.213'], ['E01.370.405.255', 'E01.370.530.255'], ['L01.906.394.211'], ['E01.370.386.700.485.750.275', 'G09.772.850.390'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C08.381.495'], ['G11.427.695'], ['G09.... | ['Anatomy [A]', 'Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Effect of adrenalectomy on weight gain and body composition of yellow obese mice (Ay/a). | It has been reported that the adrenal gland is essential to the development of obesity if Ay/a Yellow obese mice (Hausberger and Hausberger 1960). Since the actual body composition data to support this report has not been published, we attempted to duplicate this observation by adrenalectomy of the Yellow mice before t... | ['Adrenal Glands', 'Age Factors', 'Animals', 'Body Composition', 'Body Weight', 'Female', 'Lipids', 'Male', 'Mice', 'Mice, Obese', 'Proteins', 'Sex Factors'] | 1,002,103 | [['A06.300.071'], ['N05.715.350.075', 'N06.850.490.250'], ['B01.050'], ['G02.111.130', 'G03.180', 'G07.100.049'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['D10'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.150.900.649.313.992.635.5... | ['Anatomy [A]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
PriA supports two distinct pathways for replication restart in UV-irradiated Escherichia coli cells. | The Escherichia coli PriA protein loads the DnaB replicative helicase at branched DNA structures independently of the replication initiator protein, DnaA, and thereby facilitates assembly of functional replisomes at sites removed from oriC. It is therefore a critical factor in the rescue of replication forks stalled at... | ['Adenosine Triphosphatases', 'Amino Acid Sequence', 'Base Sequence', 'DNA Damage', 'DNA Helicases', 'DNA Repair', 'DNA Replication', 'DNA, Bacterial', 'DnaB Helicases', 'Escherichia coli', 'Escherichia coli Proteins', 'Models, Biological', 'Mutagenesis, Insertional', 'Recombination, Genetic', 'Suppression, Genetic', '... | 12,581,361 | [['D08.811.277.040.025'], ['G02.111.570.060', 'L01.453.245.667.060'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G05.200'], ['D08.811.277.040.025.159', 'D08.811.399.340'], ['G02.111.222', 'G05.219'], ['G02.111.225', 'G05.226'], ['D13.444.308.212'], ['D08.811.277.040.025.159.124', 'D08.811.399.340.124'... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Multiple duplications of complement C4 gene correlate with H-2-controlled testosterone-independent expression of its sex-limited isoform, C4-Slp. | Mouse liver cDNA clones related to the C4 and C4-Slp isoforms of the fourth component of complement differ by few nucleotide changes within a region of substantial divergence from human C4. It is suggested that the mouse C4 gene duplication is an evolutionarily recent event with respect to the time of mammalian radiati... | ['Animals', 'Base Sequence', 'Biological Evolution', 'Complement C4', 'DNA', 'Gene Amplification', 'Gene Expression Regulation', 'Genes', 'H-2 Antigens', 'Mice', 'Testosterone'] | 3,856,857 | [['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G05.045', 'G16.075'], ['D12.776.124.486.274.350'], ['D13.444.308'], ['G05.308.250', 'G05.365.590.310', 'G05.558.315'], ['G05.308'], ['G05.360.340.024.340'], ['D23.050.301.500.100.350', 'D23.050.301.500.400.199', 'D23.050.705.552.100.350', 'D23.0... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Azaprostaglandins. Synthesis and antiulcer activity of 11-deoxy-8-azaprostaglandin analogues. | We describe the synthesis and the antiulcer activity of new 11-deoxy-8-aza-PGE1 analogues (III a) and its C15-epimer (III b), (IV a) and its C15-epimer (IV b), featured by a triple bond in place of the C13-C14 trans double bond and a 16,16-dimethyl-17-oxabutyl omega-chain, respectively. | ['Animals', 'Anti-Ulcer Agents', 'Chemical Phenomena', 'Chemistry', 'Prostaglandins E, Synthetic', 'Rats', 'Stereoisomerism'] | 6,617,849 | [['B01.050'], ['D27.505.954.483.203'], ['G02'], ['H01.181'], ['D10.251.355.255.550.775.450', 'D23.469.050.175.725.775.450', 'D23.469.700.660'], ['B01.050.150.900.649.313.992.635.505.700'], ['G02.607.445.682']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Influence of water temperature on pressure pulses generated by an electromagnetic type lithotripter. | The need to survey and compare in vitro investigations on the effect of extracorporeally generated pressure pulses demands precise description of experimental conditions. We determined the effect of water temperature on the pressure characteristics in and around the focus area of an electromagnetic type lithotripter. T... | ['Acoustics', 'Body Temperature', 'Electromagnetic Phenomena', 'Equipment Design', 'Humans', 'Lithotripsy', 'Polyvinyls', 'Pressure', 'Signal Processing, Computer-Assisted', 'Temperature', 'Water'] | 7,754,582 | [['H01.671.031'], ['E01.370.600.875.374', 'G07.110'], ['G01.358.500'], ['E05.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.600', 'E04.943.500'], ['D02.455.326.271.665.616', 'D02.455.326.271.884.533', 'D05.750.716.721', 'D25.720.716.721', 'J01.637.051.720.716.721'], ['G01.374.715'], ['L01.224.800'], ['G0... | ['Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 |
Pharmacogenetic studies in children with acute lymphoblastic leukemia in Argentina. | The aim of this study was to evaluate the influence of the most common genetic variants in methylenetetrahydrofolate reductase (MTHFR), thiopurine methyltransferase (TPMT) and glutathione-S-transferases (GSTs) on the outcome of acute lymphoblastic leukemia (ALL) treatment in Argentinean children. Two hundred and eighty... | ['Adolescent', 'Antineoplastic Combined Chemotherapy Protocols', 'Argentina', 'Child', 'Child, Preschool', 'Female', 'Genetic Variation', 'Humans', 'Infant', 'Male', 'Methylenetetrahydrofolate Reductase (NADPH2)', 'Methyltransferases', 'Pharmacogenetics', 'Polymorphism, Single Nucleotide', 'Precursor Cell Lymphoblastic... | 25,110,820 | [['M01.060.057'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['Z01.107.757.077'], ['M01.060.406'], ['M01.060.406.448'], ['G05.365'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['D08.811.682.662.290', 'D12.776.331.775'], ['D08.811.913.555.500'], ['H01.158.273.343.750', 'H01.158.703... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
Inhibition by endothelin-1 of cholinergic nerve-mediated acetylcholine release and contraction in sheep isolated trachea. | 1. The relative roles of ETA and ETB receptor activation on cholinergic nerve-mediated contraction and acetylcholine (ACh) release were examined in sheep isolated tracheal smooth muscle. 2. Electrical field stimulation (EFS; 90 V, 0.5 ms duration, 1 Hz, 10 s train) applied to sheep isolated tracheal smooth muscle strip... | ['Acetylcholine', 'Animals', 'Atropine', 'Cholinergic Fibers', 'Endothelin-1', 'Muscle Contraction', 'Sheep', 'Tetrodotoxin', 'Time Factors', 'Trachea'] | 8,762,105 | [['D02.092.211.111'], ['B01.050'], ['D02.145.074.722.229.199', 'D03.132.760.180.572.199', 'D03.132.889.180.648.199', 'D03.605.084.500.722.229.199', 'D03.605.869.229.199'], ['A08.675.127.500', 'A08.675.542.234', 'A11.671.188.500', 'A11.671.501.234'], ['D12.644.276.400.225', 'D12.776.467.400.225', 'D23.529.400.225'], ['G... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Restriction endonuclease analysis of Marek's disease virus DNA and homology between strains. | The restriction endonuclease patterns of viral DNA obtained from serotypes 1 and 2 strains of Marek's disease virus have been compared and homology between the strains examined by hybridization. The results have shown that HPRS 16 (serotype 1) DNA has a structure similar to its attenuated variant HPRS 16/att except for... | ['Base Sequence', 'DNA Restriction Enzymes', 'DNA, Viral', 'Genes, Viral', 'Herpesvirus 2, Gallid', 'Nucleic Acid Hybridization', 'Repetitive Sequences, Nucleic Acid', 'Serotyping', 'Virulence'] | 6,319,562 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D08.811.150.280', 'D08.811.277.352.335.350.300', 'D08.811.277.352.355.325.300'], ['D13.444.308.568'], ['G05.360.340.024.340.364.875', 'G05.360.340.358.024.875', 'G05.360.340.358.840.500'], ['B04.280.382.100.562.400'], ['E05.393.661', 'G02.111.611'], ['G02.11... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
OzCare: a workflow automation system for care plans. | An automated environment for implementing and monitoring care plans and practice guidelines is very important to the reduction of hospital costs and optimization of medical care. The goal of our research effort is to design a general system architecture that facilitates the implementation of (potentially) numerous care... | ['Computer Simulation', 'Computer Systems', 'Hospital Information Systems', 'Humans', 'Management Information Systems', 'Patient Care Planning', 'Software', 'Therapy, Computer-Assisted'] | 8,947,732 | [['L01.224.160'], ['L01.224.230'], ['N04.452.442.452.452', 'N04.452.515.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N04.452.515'], ['N04.590.233.624'], ['L01.224.900'], ['E02.950', 'L01.313.500.750.100.710']] | ['Information Science [L]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Reserpine requires the D2-type receptor, dop-3 | Lifespan extension is an all systems encompassing event. Involvement of reduced insulin/IGF1 signalling is well worked out, first in the model organism Caenorhbaditis elegans followed by other systems including humans. But the role of neuronal component in lifespan extension is not well understood due to the refractory... | ['Animals', 'Behavior, Animal', 'Caenorhabditis elegans', 'Caenorhabditis elegans Proteins', 'Exoribonucleases', 'GTP-Binding Protein alpha Subunits, Gi-Go', 'Longevity', 'Multidrug Resistance-Associated Proteins', 'Mutation', 'Neurons', 'Receptors, Dopamine D2', 'Reserpine', 'Signal Transduction', 'Transcription Facto... | 27,966,489 | [['B01.050'], ['F01.145.113'], ['B01.050.500.500.294.400.875.660.250.250'], ['D12.776.419.500'], ['D08.811.277.352.365.300', 'D08.811.277.352.700.375'], ['D08.811.277.040.330.300.200.100.200', 'D12.644.360.360.100.200', 'D12.776.157.325.332.100.200', 'D12.776.476.375.100.200', 'D12.776.543.325.100.200'], ['G07.345.124.... | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Removal of haloacetic acids by nanofiltration. | Haloacetic acids, disinfection byproducts (DBPs) formed during drinking water chlorination process are carcinogens. The efficacy of nanofiltration (NF) was examined for the removal of five regulated haloacetic acids (HAA5): chloro-, dichloro-, and trichloro-acetic acid (CAA, DCAA, and TCAA); bromo-, and dibromo-acetic ... | ['Acetates', 'Filtration', 'Halogens', 'Membranes, Artificial', 'Molecular Weight', 'Nanotechnology', 'Pressure'] | 19,402,406 | [['D02.241.081.018', 'D10.251.400.045'], ['E05.196.454', 'G01.280', 'G02.263'], ['D01.268.380'], ['D25.479', 'J01.637.051.479', 'J01.637.087.500'], ['G02.494'], ['H01.603', 'J01.897.520.600'], ['G01.374.715']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Comparison of the Effects of Ultrasound-guided Erector Spinae Plane Block and Wound Infiltration on Perioperative Opioid Consumption and Postoperative Pain in Thoracotomy. | OBJECTIVE: To compare the effects of preoperative ultrasound-guided erector spinae plane block (ESPB) and preoperative wound infiltration on perioperative opioid consumption and postoperative pain in thoracotomy.STUDY DESIGN: Randomised controlled trial.PLACE AND DURATION OF STUDY: Department of Anesthesiology, Cancer ... | ['Analgesia, Patient-Controlled', 'Analgesics, Opioid', 'Female', 'Humans', 'Male', 'Middle Aged', 'Muscle, Skeletal', 'Nerve Block', 'Pain Measurement', 'Pain, Postoperative', 'Perioperative Period', 'Therapy, Computer-Assisted', 'Thoracic Vertebrae', 'Thoracotomy', 'Ultrasonography'] | 31,839,083 | [['E03.091.120'], ['D27.505.696.277.600.500', 'D27.505.696.663.850.014.760.500', 'D27.505.954.427.040.550.500', 'D27.505.954.427.210.600.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['A02.633.567', 'A10.690.552.500'], ['E03.155.086.711', 'E04.525.210.550'], ['E01.370.600.550.324'], ['C23... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Health Care [N]', 'Information Science [L]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
The complementarity of two major Australian primary mental health care initiatives. | OBJECTIVE: Two pivotal Australian Government primary mental health reforms are the Access to Allied Psychological Services (ATAPS) projects, introduced in July 2001 and implemented by Divisions of General Practice, and the Better Access to Psychiatrists, Psychologists and GPs through the Medicare Benefits Schedule (Bet... | ['Australia', 'Delivery of Health Care', 'Health Care Reform', 'Health Services Accessibility', 'Humans', 'Mental Disorders', 'Mental Health Services', 'Outcome and Process Assessment, Health Care', 'Regression Analysis', 'Rural Population', 'Socioeconomic Factors', 'Urban Population'] | 21,034,182 | [['Z01.639.100', 'Z01.678.100.373'], ['N04.590.374', 'N05.300'], ['I01.655.500.608.400.285', 'I01.880.604.825.608.400.285', 'N03.349.285', 'N03.623.500.608.428.285', 'N04.590.374.285', 'N05.300.380'], ['N04.590.374.350', 'N05.300.430'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F03'], ['F04.408', 'N02.421.461'... | ['Geographicals [Z]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Beta2-agonist induced ventricular dysrhythmias secondary to hyperexcitable conduction system in the absence of a long QT syndrome. | BACKGROUND: The use of inhaled beta 2-agonists for bronchodilation in the treatment of lower airway obstruction is accepted worldwide. These agents are used for symptomatic relief of lower airway obstruction and, as well, can be employed prophylactically in exercise-induced bronchospasm. Cardiac dysrhythmias, specifica... | ['Adrenergic beta-Agonists', 'Albuterol', 'Anti-Inflammatory Agents', 'Beclomethasone', 'Child', 'Electrocardiography', 'Electroencephalography', 'Female', 'Heart Conduction System', 'Heart Diseases', 'Humans', 'Long QT Syndrome', 'Nedocromil', 'Pedigree', 'Syncope', 'Ventricular Dysfunction'] | 9,048,534 | [['D27.505.519.625.050.100.200', 'D27.505.696.577.050.100.200'], ['D02.033.100.291.057', 'D02.092.063.291.057', 'D02.092.471.683.061'], ['D27.505.954.158'], ['D04.210.500.745.432.769.125', 'D04.210.500.883.154'], ['M01.060.406'], ['E01.370.370.380.240', 'E01.370.405.240'], ['E01.370.376.300', 'E01.370.405.245'], ['A07.... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Natural history of drusen morphology in age-related macular degeneration using spectral domain optical coherence tomography. | PURPOSE: To characterize the natural history of drusen using spectral-domain optical coherence tomography (SD-OCT) imaging of eyes from patients with nonexudative age-related macular degeneration (AMD).DESIGN: Prospective, longitudinal, natural history study.PARTICIPANTS: We included 143 eyes of 100 patients with at le... | ['Aged', 'Aged, 80 and over', 'Algorithms', 'Female', 'Follow-Up Studies', 'Fourier Analysis', 'Humans', 'Macular Degeneration', 'Male', 'Middle Aged', 'Prospective Studies', 'Retinal Drusen', 'Time Factors', 'Tomography, Optical Coherence'] | 21,724,264 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['G17.035', 'L01.224.050'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['E05.377', 'G17.226', 'L01.224.800.625'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C11.768.585.439'], ['M01.060.116.630'], ['E05.318.372.500.75... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Unethical ethics? Reflections on intercultural research practices. | The notion that there is a universal ethics is commonly supposed, but less often explicitly discussed, in protocols for ethical procedures in research. In this article, the authors reflect on their action-research with women farmers in a Bolivian highland province. Their project aims to propose ways in which local heal... | ['Adult', 'Bolivia', 'Culture', 'Ethics', 'Female', 'Human Experimentation', 'Humans', 'Informed Consent', 'Power, Psychological'] | 11,424,256 | [['M01.060.116'], ['Z01.107.757.136'], ['I01.076.201.450', 'I01.880.853.100'], ['K01.752.566.479', 'N05.350'], ['E05.445', 'H01.770.644.145.365'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I01.880.604.473.650.718', 'I01.880.604.583.427', 'N03.706.437.650.312', 'N03.706.535.489'], ['F01.658.780']] | ['Named Groups [M]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
The mechanism of the bond forming events in pyridine nucleotide linked oxidoreductases. Studies with epoxide inhibitors of lactic dehydrogenase and beta-hydroxybutyrate dehydrogenase. | 2,3-Epoxybutyrate and 2,3-epoxypropionate act as effective competitive inhibitors of pig heart lactic dehydrogenase. KIapp for both inhibitors was pH dependent and varied according to the general equation KIapp = KI(1 +Ka/H+) which may be predicted if the binding of the epoxide to the E-NADH complex involves a compulso... | ['Animals', 'Binding Sites', 'Epoxy Compounds', 'Ethers, Cyclic', 'Hydrogen-Ion Concentration', 'Hydroxybutyrate Dehydrogenase', 'Kinetics', 'L-Lactate Dehydrogenase', 'Myocardium', 'Protein Binding', 'Protein Conformation', 'Rhodobacter sphaeroides', 'Spectrometry, Fluorescence', 'Swine'] | 238,558 | [['B01.050'], ['G02.111.570.120'], ['D02.355.291.411'], ['D02.355.291', 'D04.345.241'], ['G02.300'], ['D08.811.682.047.820.350'], ['G01.374.661', 'G02.111.490'], ['D08.811.682.047.551.400', 'D08.811.682.047.820.493'], ['A02.633.580', 'A07.541.704', 'A10.690.552.750'], ['G02.111.679', 'G03.808'], ['G02.111.570.820.709']... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A fast selenium derivatization strategy for crystallization and phasing of RNA structures. | Site-specific 2'-methylseleno RNA labeling is a promising tool for tackling the phase problem in RNA crystallography. We have developed an efficient strategy for crystallization and structure determination of RNA and RNA/protein complexes based on preliminary crystallization screening of 2'-OCH(3)-modified RNA sequence... | ['Base Sequence', 'Crystallography, X-Ray', 'HIV-1', 'Nucleic Acid Conformation', 'RNA', 'Selenium', 'Staining and Labeling'] | 19,228,585 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.196.309.742.225'], ['B04.820.650.589.650.350.400'], ['G02.111.570.820.486', 'G05.360.580'], ['D13.444.735'], ['D01.268.185.850', 'D01.578.700'], ['E01.370.225.500.620.670', 'E01.370.225.750.600.670', 'E05.200.500.620.670', 'E05.200.750.600.670']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
[Treatment of progressive muscular dystrophy]. | The paper summarizes experience in treating 306 patients with progressive muscular dystrophy during different phases of the disease. The treatment was made with due consideration for a disturbed protein metabolism, a decreased permeability of the membrane in muscular filaments, a normalization of the metabolic product ... | ['Adolescent', 'Adult', 'Aged', 'Balneology', 'Child', 'Child, Preschool', 'Electric Stimulation Therapy', 'Exercise Therapy', 'Female', 'Humans', 'Hyperbaric Oxygenation', 'Infant', 'Male', 'Massage', 'Middle Aged', 'Moscow', 'Movement Disorders', 'Muscular Dystrophies', 'Physical Therapy Modalities', 'Time Factors'] | 1,080,939 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['E02.056'], ['M01.060.406'], ['M01.060.406.448'], ['E02.331', 'E02.779.468', 'E02.831.535.468'], ['E02.760.169.063.500.387', 'E02.779.483', 'E02.831.535.483'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.880.690.490'], ['M01.060.703'], ['E02.190.599.75... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
Quantitative determination of the macrolide antibiotic tulathromycin in plasma and broncho-alveolar cells of foals using tandem mass spectrometry. | The long-acting antibiotic tulathromycin is on the marked for treatment of pulmonary infection of cattle, swine and horses. To measure disposition and distribution of tulathromycin in foals, a high throughput method was developed for horse plasma (calibration range: 0.006-0.8 microg/mL) and broncho-alveolar cells (cali... | ['Animals', 'Anti-Bacterial Agents', 'Bronchoalveolar Lavage Fluid', 'Disaccharides', 'Heterocyclic Compounds', 'Horses', 'Reference Standards', 'Tandem Mass Spectrometry'] | 17,267,304 | [['B01.050'], ['D27.505.954.122.085'], ['E05.927.100.500'], ['D09.698.629.305', 'D09.947.750'], ['D03'], ['B01.050.150.900.649.313.984.235.472'], ['E05.978.808'], ['E05.196.566.880']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[The effect of NaK2Cl symport and chloride channel permeability on ion flux balance and on transmembrane ion distribution in different types of animal cells]. | The relationships between monovalent ion fluxes via major cell membrane pathways (Na/K pump, NaK2Cl symporter, electroconductive sodium, potassium and chloride channels) and steady state transmembrane ion distribution, membrane potential and cell water content were calculated for the high potassium animal cells with hi... | ['Animals', 'Biological Transport, Active', 'Carrier Proteins', 'Cell Membrane Permeability', 'Chloride Channels', 'Chlorides', 'Computer Simulation', 'Electrochemistry', 'Ion Transport', 'Membrane Potentials', 'Membrane Proteins', 'Models, Biological', 'Potassium', 'Sodium', 'Sodium-Potassium-Chloride Symporters'] | 9,490,512 | [['B01.050'], ['G03.143.310'], ['D12.776.157'], ['G03.143.335', 'G04.175'], ['D12.776.157.530.400.175', 'D12.776.543.550.450.175', 'D12.776.543.585.400.175'], ['D01.210.450.150', 'D01.248.497.158.215'], ['L01.224.160'], ['H01.181.529.307'], ['G03.143.500'], ['G01.154.535', 'G04.580', 'G07.265.675', 'G11.561.570'], ['D1... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Information Science [L]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Validity of four screening scales for major depression in MS. | BACKGROUND: There is a role for brief assessment instruments in detection and management of major depression in MS. However, candidate scales have rarely been validated against a validated diagnostic interview. In this study, we evaluated the performance of several candidate scales: Patient Health Questionnaire (PHQ)-9... | ['Age of Onset', 'Depressive Disorder, Major', 'Diagnostic and Statistical Manual of Mental Disorders', 'Female', 'Humans', 'Male', 'Middle Aged', 'Multiple Sclerosis', 'Predictive Value of Tests', 'Psychiatric Status Rating Scales', 'ROC Curve', 'Recurrence', 'Reproducibility of Results', 'Surveys and Questionnaires',... | 25,583,846 | [['N05.715.350.075.100', 'N06.850.490.250.100'], ['F03.600.300.375'], ['L01.453.245.945.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C10.114.375.500', 'C10.314.350.500', 'C20.111.258.250.500'], ['E05.318.370.800.650', 'N05.715.360.325.700.640', 'N06.850.520.445.800.650'], ['F04.711.513... | ['Health Care [N]', 'Psychiatry and Psychology [F]', 'Information Science [L]', 'Organisms [B]', 'Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Endogenous cannabinoids as an aversive or counter-rewarding system in the rat. | Human use of marijuana (Cannabis sativa) is widely assumed to have rewarding properties, a notion supported by its widespread recreational use. However, no study has clearly demonstrated such effects in animal models. The purpose of this study was to test for the presumed rewarding effect of cannabinoids using a condit... | ['Animals', 'Avoidance Learning', 'Cannabinoids', 'Conditioning, Psychological', 'Dose-Response Relationship, Drug', 'Dronabinol', 'Male', 'Piperidines', 'Pyrazoles', 'Rats', 'Rats, Sprague-Dawley', 'Reward', 'Rimonabant'] | 9,089,689 | [['B01.050'], ['F02.463.425.097', 'F02.463.785.373.173'], ['D02.455.849.090'], ['F02.463.425.179'], ['G07.690.773.875', 'G07.690.936.500'], ['D02.455.849.090.810'], ['D03.383.621'], ['D03.383.129.539'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.750'], ['F02.463.425.770.836']... | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Long-term glucose infusion increases arterial pressure in dogs with cyclooxygenase-2 inhibition. | A series of studies has shown that long-term infusion of insulin and glucose does not increase mean arterial pressure (MAP) in dogs, but we have shown that the same infusion protocol or infusion of glucose alone increases arterial pressure in rats. This study tested the hypothesis that infusing glucose alone in dogs, w... | ['Animals', 'Blood Glucose', 'Blood Pressure', 'Cyclooxygenase 2', 'Dogs', 'Enzyme Inhibitors', 'Glomerular Filtration Rate', 'Glucose', 'Hyperinsulinism', 'Infusions, Intravenous', 'Insulin', 'Insulin Secretion', 'Isoenzymes', 'Potassium', 'Prostaglandin-Endoperoxide Synthases', 'Prostaglandins', 'Sodium', 'Sulfonamid... | 11,230,365 | [['B01.050'], ['D09.947.875.359.448.500'], ['E01.370.600.875.249', 'G09.330.380.076'], ['D08.811.600.720.750'], ['B01.050.150.900.649.313.750.250.216.200'], ['D27.505.519.389'], ['E01.370.390.400.300', 'G08.852.357'], ['D09.947.875.359.448'], ['C18.452.394.968'], ['E02.319.267.082.500', 'E02.319.267.510.590'], ['D06.47... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Abortions, stillbirths and deformities in sheep at the Al-Ahsa oasis in eastern Saudi Arabia: isolation of a bluetongue serogroup virus from the affected lambs. | A wave of abortions, stillbirths and deformities in sheep occurred at the Al-Ahsa oasis in the eastern region of Saudi Arabia in the second half of 1999. The abortions were recorded in August and September and stillbirths and deformities in neonates were observed in October. Adult sheep were clinically normal. A virus ... | ['Abortion, Veterinary', 'Animals', 'Animals, Newborn', 'Antibodies, Viral', 'Bluetongue', 'Bluetongue virus', 'Chick Embryo', 'Congenital Abnormalities', 'Disease Outbreaks', 'Female', 'Pregnancy', 'Pregnancy Outcome', 'Radiography', 'Saudi Arabia', 'Serotyping', 'Sheep'] | 15,861,886 | [['C13.703.039.422', 'C22.021'], ['B01.050'], ['B01.050.050.282'], ['D12.776.124.486.485.114.254', 'D12.776.124.790.651.114.254', 'D12.776.377.715.548.114.254'], ['C01.920.500.125', 'C01.925.081.125', 'C01.925.782.791.315', 'C22.836.120'], ['B04.820.223.719.550.100'], ['A13.350.150', 'A16.331.200'], ['C16.131'], ['N06.... | ['Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
[Successful Combined Modality Therapy for an Advanced Malignant Mediastinal Non-seminomatous Germ Cell Tumor in an Elderly Female]. | A 69-year-old woman was diagnosed with a germ cell tumor in the anterior mediastinum. Following 3 years follow-up, she experienced chest pain and an enlarging of the anterior mediastinal tumor and bilateral lung metastases were detected by chest X-ray. The tumor was diagnosed as a primary malignant mediastinal non-semi... | ['Aged', 'Antineoplastic Combined Chemotherapy Protocols', 'Biopsy, Needle', 'Chemoradiotherapy', 'Female', 'Humans', 'Lung Neoplasms', 'Mediastinal Neoplasms', 'Neoplasms, Germ Cell and Embryonal', 'Treatment Outcome'] | 28,595,223 | [['M01.060.116.100'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['E01.370.225.500.384.100.119', 'E01.370.225.998.054.119', 'E01.370.388.100.100', 'E04.074.119', 'E04.665.100', 'E05.200.500.384.100.119', 'E05.200.998.054.119', 'E05.242.384.100.119'], ['E02.186.079', 'E02.319.164', 'E02.815.160'], ['B01.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Pharmacokinetics of Praziquantel in Schistosoma mansoni- and Schistosoma haematobium-Infected School- and Preschool-Aged Children. | There is a growing consensus to include preschool-aged children in preventive chemotherapy programs with praziquantel to improve schistosomiasis control. However, pharmacokinetic data, crucial to establish a safe and effective dose for this age group, are sparse. The objective of this study was to establish and compare... | ['Adolescent', 'Animals', 'Child', 'Child, Preschool', 'Chromatography, Liquid', 'Humans', 'Praziquantel', 'Schistosoma haematobium', 'Schistosoma mansoni', 'Schistosomiasis mansoni', 'Tandem Mass Spectrometry'] | 29,866,859 | [['M01.060.057'], ['B01.050'], ['M01.060.406'], ['M01.060.406.448'], ['E05.196.181.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.633.100.531.690'], ['B01.050.500.500.736.715.770.680.510'], ['B01.050.500.500.736.715.770.680.700'], ['C01.610.335.865.859.576', 'C01.920.922.576'], ['E05.196.566.880']] | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Valsalva manoeuvre in patients with different Parkinsonian disorders. | The valsalva manoeuvre (VM), used as an autonomic function test, can detect sympathetic and/or parasympathetic autonomic dysfunction. This study investigated the value of VM in patients with different Parkinsonian syndromes (PS). We continuously recorded blood pressure, ECG and respiration among 38 patients with multip... | ['Aged', 'Autonomic Nervous System Diseases', 'Blood Pressure', 'Cardiovascular Physiological Phenomena', 'Diagnosis, Differential', 'Electrocardiography', 'Female', 'Humans', 'Male', 'Middle Aged', 'Multiple System Atrophy', 'Parkinson Disease', 'Parkinsonian Disorders', 'Posture', 'Predictive Value of Tests', 'Respir... | 19,499,177 | [['M01.060.116.100'], ['C10.177'], ['E01.370.600.875.249', 'G09.330.380.076'], ['G09.330'], ['E01.171'], ['E01.370.370.380.240', 'E01.370.405.240'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C10.177.575.550', 'C10.228.140.079.612', 'C10.228.662.550', 'C10.574.928.625'], ['C10.228.140.079.8... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Small molecule-based chemotherapeutic approach in p16-positive and -negative HNSCC in vitro. | BACKGROUND: Incidence of oropharyngeal head and neck squamous cell carcinoma (HNSCC) induced by the human papilloma virus (HPV) is rising. HNSCC is the sixth most common neoplasia worldwide. The survival rate remains poor, thus innovative therapy approaches are necessary. Everolimus, an inhibitor of the mammalian targe... | ['Antineoplastic Agents', 'Carcinoma, Non-Small-Cell Lung', 'Cell Line, Tumor', 'Enzyme-Linked Immunosorbent Assay', 'Human papillomavirus 16', 'Humans', 'Hypoxia-Inducible Factor 1, alpha Subunit', 'In Vitro Techniques', 'Lung Neoplasms', 'Receptor, Platelet-Derived Growth Factor alpha', 'Receptor, Platelet-Derived Gr... | 24,324,073 | [['D27.505.954.248'], ['C04.588.894.797.520.109.220.249', 'C08.381.540.140.500', 'C08.785.520.100.220.500'], ['A11.251.210.190', 'A11.251.860.180'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['B04.280.210.655.050.616', 'B04.613.204.655.050.616']... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Exercise capacity and blood pressure associations with left ventricular mass in prehypertensive individuals. | Prehypertensive individuals are at increased risk for developing hypertension and cardiovascular disease compared with those with normal blood pressure. Early compromises in left ventricular structure may explain part of the increased risk. We assessed echocardiographic and exercise parameters in prehypertensive indivi... | ['Adult', 'Blood Pressure', 'Differential Threshold', 'Echocardiography', 'Exercise', 'Female', 'Heart Ventricles', 'Humans', 'Hypertension', 'Hypertrophy, Left Ventricular', 'Likelihood Functions', 'Male', 'Middle Aged', 'Physical Endurance', 'Physical Fitness', 'Predictive Value of Tests', 'Risk Assessment', 'Systole... | 17,088,448 | [['M01.060.116'], ['E01.370.600.875.249', 'G09.330.380.076'], ['F02.463.593.710.370'], ['E01.370.350.130.750', 'E01.370.350.850.220', 'E01.370.370.380.220'], ['G11.427.410.698.277', 'I03.350'], ['A07.541.560'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['C14.280.195.400', 'C23.300.775.250.400'],... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Quantification of mutagenic/carcinogenic heterocyclic amines, MeIQx, Trp-P-1, Trp-P-2 and PhIP, contributing highly to genotoxicity of river water. | Four mutagenic/carcinogenic heterocyclic amines (HCAs), 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1), 3-amino-1-methyl-5H-pyrido[4,3-b]indole(Trp-P-2) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), in organic extracts obtained by blue rayon ha... | ['Amines', 'Animals', 'Carbolines', 'Carcinogens', 'Cellulose', 'Chromatography, High Pressure Liquid', 'Fresh Water', 'Imidazoles', 'In Vitro Techniques', 'Japan', 'Mutagenicity Tests', 'Mutagens', 'Quinoxalines', 'Rats', 'Salmonella typhimurium', 'Water Pollutants, Chemical'] | 9,357,563 | [['D02.092'], ['B01.050'], ['D03.383.725.150', 'D03.633.100.473.155', 'D03.633.300.154'], ['D27.888.569.100'], ['D05.750.078.562.180', 'D09.698.365.180', 'D25.720.099.500', 'J01.637.051.720.099.500'], ['E05.196.181.400.300'], ['G16.500.275.280', 'N06.230.232'], ['D03.383.129.308'], ['E05.481'], ['Z01.252.474.463', 'Z01... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
[Analysis of the extent of harm from digitally modulated mobile telephone rays]. | In the public discussion regarding the health risks of mobile phone system radiation, it is emphasized that the pulse slope of digital modulation, as defined in the GSM-Standard, will cause biological effects. In contrast, the high field strength of broadcasting and television radiation is not considered to be relevant... | ['Humans', 'Radiation Dosage', 'Radiographic Image Enhancement', 'Risk Assessment', 'Telephone'] | 12,375,454 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.799.513', 'G01.750.740', 'N06.850.810.250'], ['E01.370.350.600.350.700', 'E01.370.350.700.700', 'L01.224.308.380.600'], ['E05.318.740.600.800.715', 'N04.452.871.715', 'N05.715.360.750.625.700.690', 'N06.850.505.715', 'N06.850.520.830.600.800.715'], ['L01.178.847.6... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Effects of relative phase and frequency spacing on the detection of three-component amplitude modulation. | These experiments explored the effect of relative modulator phase on the detection of a three-component modulator applied to a 4,000-Hz sinusoidal carrier with a level of 70 dB SPL. The central modulator component had a frequency of 50 Hz, and the two other components had frequencies of 50+/-5, 10, 25, 40, or 45 Hz. Th... | ['Auditory Threshold', 'Basilar Membrane', 'Humans', 'Psychoacoustics', 'Psychometrics', 'Time Factors'] | 11,108,374 | [['F02.463.593.071.173', 'F02.463.593.710.190', 'G07.888.125.173'], ['A09.246.300.246.125', 'A10.615.179.124'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.382.375.060.530', 'E01.370.685.628', 'F04.096.753.628'], ['F04.711.780'], ['G01.910.857']] | ['Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Genomewide analysis of the lateral organ boundaries domain gene family in Vitis vinifera. | In plants, the transcription factor families have been implicated in many important biological processes. These processes include morphogenesis, signal transduction and environmental stress responses. Proteins containing the lateral organ boundaries domain (LBD), which encodes a zinc finger-like domain are only found i... | ['Arabidopsis', 'Arabidopsis Proteins', 'Chromosome Mapping', 'Chromosomes, Plant', 'Cold Temperature', 'Exons', 'Gene Expression Regulation, Developmental', 'Gene Expression Regulation, Plant', 'Gene Ontology', 'Genome, Plant', 'Hot Temperature', 'Introns', 'Mannitol', 'Microarray Analysis', 'Molecular Sequence Annota... | 27,659,322 | [['B01.650.940.800.575.912.250.157.100'], ['D12.776.765.149'], ['E05.393.183'], ['A11.284.187.560', 'A18.005', 'G05.360.162.560'], ['G01.906.595.272', 'G16.500.275.063.725.710.300', 'G16.500.750.775.710.300', 'N06.230.300.100.725.154', 'N06.230.300.100.725.710.300'], ['G05.360.340.024.340.137.232'], ['G05.308.310'], ['... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Information Science [L]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Integrative technology for the twenty-first century. | Presented is the concept of Integrative Technology, the intersection of the precision assembly of matter (nanotechnology), coupled with the functional building blocks of nature (biotechnology), and fused by the network flow of spatiotemporal information (informatics). The power of Integrative Technology is illuminated ... | ['Biomimetics', 'Biotechnology', 'Computational Biology', 'Computers, Molecular', 'Forecasting', 'Ion Channels', 'Nanotechnology', 'Neural Networks, Computer', 'Neurons', 'Systems Integration', 'Technology'] | 15,194,606 | [['H01.158.550.100', 'J01.897.120.100'], ['H01.158.550', 'J01.897.120'], ['H01.158.273.180', 'L01.313.124'], ['L01.224.230.260.315', 'L01.224.300'], ['I01.320'], ['D12.776.157.530.400', 'D12.776.543.550.450', 'D12.776.543.585.400'], ['H01.603', 'J01.897.520.600'], ['G17.485', 'L01.224.050.375.605'], ['A08.675', 'A11.67... | ['Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
Enhanced solubility and oral bioavailability of itraconazole by combining membrane emulsification and spray drying technique. | The objective of the present study was to enhance solubility and bioavailability of itraconazole by a combined use of membrane emulsification and spray drying solidification technique. A shirasu-porous-glass (SPG) membrane with a mean pore size of 2.5 ìm was used to produce monodispersed microemulsions of itraconazole ... | ['Administration, Oral', 'Animals', 'Area Under Curve', 'Biological Availability', 'Crystallization', 'Dextrans', 'Drug Carriers', 'Emulsions', 'Ethylene Glycols', 'Excipients', 'Hexoses', 'Itraconazole', 'Male', 'Methylene Chloride', 'Rats', 'Rats, Sprague-Dawley', 'Solubility', 'Temperature'] | 22,643,224 | [['E02.319.267.100'], ['B01.050'], ['E05.318.740.200', 'G03.787.101', 'G07.690.725.064', 'N06.850.520.830.200'], ['G03.787.151', 'G07.690.725.129'], ['E05.196.300', 'G02.171'], ['D05.750.078.562.272', 'D09.698.365.272'], ['D26.255.260', 'E02.319.300.380'], ['D20.280.260', 'D26.255.165.260'], ['D02.033.455.250'], ['D26.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Age at acquisition of Helicobacter pylori infection: a follow-up study from infancy to adulthood. | BACKGROUND: Helicobacter pylori infection is common worldwide, but the time of acquisition is unclear. We investigated this issue in a cohort of children selected retrospectively from a population followed up for 21 years.METHODS: We monitored 224 children (99 black, 125 white; 110 male, 114 female) from 1975-76 (ages ... | ['Adult', 'African Continental Ancestry Group', 'Age Distribution', 'Antibodies, Bacterial', 'Child, Preschool', 'Cohort Studies', 'European Continental Ancestry Group', 'Female', 'Follow-Up Studies', 'Helicobacter Infections', 'Helicobacter pylori', 'Humans', 'Infant', 'Louisiana', 'Male', 'Prevalence', 'Risk Factors'... | 11,918,912 | [['M01.060.116'], ['M01.686.508.100'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['D12.776.124.486.485.114.107', 'D12.776.124.790.651.114.125', 'D12.776.377.715.548.114.125'], ['M01.060.406.448'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['M01.686.508.400'], ['E05.318.... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Nutritional role of two algal symbionts in the temperate sea anemone Anthopleura elegantissima brandt. | The intertidal sea anemone Anthopleura elegantissima in the Pacific Northwest may host a single type of algal symbiont or two different algal symbionts simultaneously: zooxanthellae (Symbiodinium muscatinei) and zoochlorellae (green algae; Trebouxiophyceae, Chlorophyta). A seasonal comparison of zooxanthellate and zooc... | ['Animals', 'Biomass', 'Carbon', 'Carbon Isotopes', 'Chlorophyta', 'Heterotrophic Processes', 'Nitrogen Isotopes', 'Photosynthesis', 'Pigments, Biological', 'Sea Anemones', 'Seasons', 'Symbiosis'] | 18,723,639 | [['B01.050'], ['G16.500.275.157.100', 'N06.230.124.100'], ['D01.268.150'], ['D01.268.150.075', 'D01.496.123'], ['B01.650.940.150'], ['G02.111.375', 'G03.393'], ['D01.268.604.500', 'D01.362.625.500', 'D01.496.586'], ['G02.111.158.937', 'G02.111.669.700', 'G02.740.921', 'G03.191.937', 'G03.493.700', 'G03.800.700', 'G15.5... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Corneal topography-guided penetrating keratoplasty and suture adjustment: new approach for astigmatism control. | PURPOSE: To describe a new keratoplasty procedure using intraoperative topography to reduce postoperative astigmatism.METHODS: One hundred sixty-five eyes of 150 consecutive patients were enrolled in this prospective study. The most common diagnosis was keratoconus (78.8%). As many as 5.5% had post-laser in situ kerato... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Astigmatism', 'Corneal Topography', 'Female', 'Follow-Up Studies', 'Humans', 'Keratoplasty, Penetrating', 'Male', 'Middle Aged', 'Monitoring, Intraoperative', 'Prospective Studies', 'Suture Techniques', 'Visual Acuity'] | 17,592,315 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C11.744.212'], ['E01.370.380.150'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.095.147.725.225.350', 'E04.540.825.374.350', 'E04.936.5... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
An economic assessment of analogue basal-bolus insulin versus human basal-bolus insulin in subjects with type 1 diabetes in the UK. | BACKGROUND: A recent study demonstrated that treatment of type 1 diabetes with an analogue basal-bolus insulin regimen was associated with improved glycaemic control (HbA(1c) -0.22% points, p < 0.001), reduced risk of hypoglycaemic events (-21%, p = 0.036) and reduction in body mass index (-0.30 kg/m(2), p < 0.001) com... | ['Adult', 'Computer Simulation', 'Cost-Benefit Analysis', 'Diabetes Mellitus, Type 1', 'Drug Therapy, Combination', 'Female', 'Humans', 'Insulin', 'Male', 'Middle Aged', 'Models, Economic', 'Patient Acceptance of Health Care', 'Randomized Controlled Trials as Topic', 'United Kingdom'] | 17,407,646 | [['M01.060.116'], ['L01.224.160'], ['N03.219.151.125'], ['C18.452.394.750.124', 'C19.246.267', 'C20.111.327'], ['E02.319.310'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D06.472.699.587.200.500.625', 'D12.644.548.586.200.500.625'], ['M01.060.116.630'], ['E05.318.740.500.600', 'E05.599.835.890', 'N05.715.360.75... | ['Named Groups [M]', 'Information Science [L]', 'Health Care [N]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
Negative regulation of ERá by a novel protein CAC1 through association with histone demethylase LSD1. | ERá, a critical transcriptional factor for breast cancer proliferation, is regulated by a complex binding repertoire that includes coactivators and corepressors. Here, we identified a novel class of ERá coregulator called CAC1. The CoRNR box of CAC1 was required for the binding to and inactivation of ERá. CAC1 also ass... | ['Antineoplastic Agents', 'Breast Neoplasms', 'Cell Death', 'Cell Line, Tumor', 'Co-Repressor Proteins', 'Cullin Proteins', 'Drug Resistance, Neoplasm', 'Estrogen Receptor alpha', 'Female', 'Gene Expression Regulation, Neoplastic', 'Genes, Reporter', 'Histone Demethylases', 'Histones', 'Humans', 'Mutant Proteins', 'Neo... | 23,178,685 | [['D27.505.954.248'], ['C04.588.180', 'C17.800.090.500'], ['G04.146'], ['A11.251.210.190', 'A11.251.860.180'], ['D12.776.930.780.625'], ['D08.811.464.938.750.750.500', 'D12.776.167.175'], ['G07.690.773.984.395'], ['D12.776.826.750.350.174'], ['G05.308.370'], ['G05.360.340.024.340.435'], ['D08.811.682.662.582.475'], ['D... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Gene expression-based classification of nonseminomatous male germ cell tumors. | Male adult germ cell tumors (GCTs) comprise two major histologic groups: seminomas and nonseminomas. Nonseminomatous GCTs (NSGCTs) can be further divided into embryonal carcinoma (EC), teratoma (T), yolk sac tumor (YS), and choriocarcinoma (CC) on the basis of the lineage differentiation that they exhibit. NSGCTs frequ... | ['Gene Expression Profiling', 'Gene Expression Regulation, Neoplastic', 'Genital Neoplasms, Male', 'Humans', 'Male', 'Reverse Transcriptase Polymerase Chain Reaction', 'Seminoma', 'Teratoma', 'Testicular Neoplasms', 'Transcription, Genetic'] | 15,870,693 | [['E05.393.332'], ['G05.308.370'], ['C04.588.945.440', 'C12.294.260', 'C12.758.409'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.393.620.500.725'], ['C04.557.465.330.800'], ['C04.557.465.910'], ['C04.588.322.762', 'C04.588.945.440.915', 'C12.294.260.937', 'C12.758.409.937', 'C19.344.762', 'C19.391.829.782']... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Differential regulation of apoptosis by caspase-mediated cleavage of phospholipase D isozymes. | Phospholipase D (PLD) has been implicated in survival and anti-apoptosis, but the molecular mechanism by which it responds to apoptotic stimuli is poorly unknown. Here, we demonstrate that cleavage of PLD isozymes as specific substrates of caspase differentially regulates apoptosis. PLD1 is cleaved at one internal site... | ['Amino Acid Sequence', 'Animals', 'Apoptosis', 'Base Sequence', 'Caspases', 'Cells, Cultured', 'Gene Expression Regulation', 'Gene Knockdown Techniques', 'Humans', 'Isoenzymes', 'Mice', 'Molecular Sequence Data', 'Mutagenesis, Site-Directed', 'Phospholipase D', 'RNA, Small Interfering', 'TNF-Related Apoptosis-Inducing... | 18,694,819 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G04.146.954.035'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D08.811.277.656.262.500.126', 'D08.811.277.656.300.200.126', 'D12.644.360.075.405', 'D12.776.476.075.405'], ['A11.251'], ['G05.308'], ['E05.393.335.500'], ['B01.050.150.900.649.313... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
CYP2C19 polymorphism affects single-dose pharmacokinetics of oral pantoprazole in healthy volunteers. | OBJECTIVES: Pantoprazole is metabolized by cytochrome P450 2 C19, which shows genetic polymorphism. The effect of CYP2C19 polymorphism on single-dose pharmacokinetics of oral pantoprazole in healthy volunteers was evaluated.METHODS: Pantoprazole pharmacokinetics was determined in 32 healthy volunteers after a 40-mg sin... | ['2-Pyridinylmethylsulfinylbenzimidazoles', 'Administration, Oral', 'Adult', 'Area Under Curve', 'Aryl Hydrocarbon Hydroxylases', 'Biotransformation', 'Cytochrome P-450 CYP2C19', 'Female', 'Half-Life', 'Heterozygote', 'Homozygote', 'Humans', 'Male', 'Metabolic Clearance Rate', 'Models, Biological', 'Pantoprazole', 'Phe... | 22,418,828 | [['D02.886.640.074', 'D03.383.725.024', 'D03.633.100.103.034'], ['E02.319.267.100'], ['M01.060.116'], ['E05.318.740.200', 'G03.787.101', 'G07.690.725.064', 'N06.850.520.830.200'], ['D08.244.453.005', 'D08.811.682.690.708.170.010', 'D12.776.422.220.453.010'], ['G03.171', 'G03.787.225', 'G07.690.725.225'], ['D08.244.453.... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
The Effect of Cognitive-Emotional Intervention on Growth and Posttraumatic Stress in Mothers of Children With Cancer: A Randomized Clinical Trial. | BACKGROUND: To diminish the negative impact and improve the positive outcomes on the parents of children with cancer, it is crucial to attend to their problems. This is especially significant in the case of mothers as the main caregivers. The present study aimed at evaluating the efficiency of cognitive-emotional inter... | ['Adult', 'Case-Control Studies', 'Child, Preschool', 'Cognitive Behavioral Therapy', 'Emotions', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Mothers', 'Neoplasms', 'Posttraumatic Growth, Psychological', 'Stress Disorders, Post-Traumatic', 'Stress, Psychological'] | 31,318,821 | [['M01.060.116'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['M01.060.406.448'], ['F04.754.137.350'], ['F01.470'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.263.500.320.200', ... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
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