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Deterioration of spatial learning performances in lipopolysaccharide-treated mice. | It is well demonstrated that acute or chronic stress leads to reduction of learning ability. Lipopolysaccharide (LPS), a component of the outer membrane of gram-negative bacteria, induces profound physiological and behavioral changes, including fever, decrease in food motivation, and decrease in social behavior. These ... | ['Animals', 'Avoidance Learning', 'Hippocampus', 'Lipopolysaccharides', 'Long-Term Potentiation', 'Male', 'Maze Learning', 'Mice', 'Mice, Inbred C57BL', 'Spatial Behavior'] | 11,885,968 | [['B01.050'], ['F02.463.425.097', 'F02.463.785.373.173'], ['A08.186.211.180.405', 'A08.186.211.200.885.287.500.345'], ['D09.400.500', 'D09.698.718.450', 'D10.494', 'D23.050.161.616.525', 'D23.946.123.329.500'], ['G11.561.638.350'], ['F02.463.425.874.500'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.... | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The effect of type and concentration of vehicles on the dissolution rate of a poorly soluble drug (indomethacin) from liquisolid compacts. | PURPOSE: For poorly soluble, highly permeable (Class II) drugs, such as indomethacin, the rate of oral absorption is often controlled by the dissolution rate in the gastrointestinal tract. Therefore together with the permeability, the solubility and dissolution behaviour of a drug are key determinants of its oral bioav... | ['Chemistry, Pharmaceutical', 'Compressive Strength', 'Drug Carriers', 'Indomethacin', 'Pharmaceutical Vehicles', 'Solubility', 'Solvents', 'Tablets, Enteric-Coated'] | 15,946,594 | [['H01.158.703.007', 'H01.181.466'], ['G01.374.180'], ['D26.255.260', 'E02.319.300.380'], ['D03.633.100.473.420'], ['D26.650.700', 'D27.720.744.770', 'E02.319.300.754'], ['G02.805'], ['D27.720.844'], ['D26.255.210.860', 'D26.255.830.860']] | ['Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Using the World Wide Web to revolutionise technology transfer and training in the water and wastewater industries. | Industry professionals of the near future will be supported by an IT infrastructure that enables them to complete a task by drawing on resources and people with expertise anywhere in the world, and access to knowledge through specific training programs that address the task requirements. The increasing uptake of new te... | ['Diffusion of Innovation', 'Education', 'Industry', 'Internet', 'Professional Competence', 'Technology Transfer', 'Waste Disposal, Fluid', 'Water Purification', 'Water Supply'] | 11,547,975 | [['L01.143.320'], ['I02'], ['J01.576'], ['L01.224.230.110.500'], ['I02.399.630'], ['J01.897.900', 'L01.143.320.800'], ['N06.850.780.200.800.800.890', 'N06.850.860.510.900.600.900'], ['N06.850.780.200.800.800.900.900', 'N06.850.860.510.900.900'], ['J01.293.821.500']] | ['Information Science [L]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]'] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 |
A miniaturized monitoring system for electrochemical biosensing using Shewanella oneidensis in environmental applications. | We present a miniaturized, free-floating monitoring system which makes use of electron transfer in Shewanella oneidensis sequestered behind a permeable membrane while maintaining diffusive contact with the environment, allowing for sensing environmental conditions. The system makes use of a commercial off-the-shelf (CO... | ['Biosensing Techniques', 'Electrochemical Techniques', 'Electrodes', 'Electron Transport', 'Environmental Microbiology', 'Escherichia coli', 'Shewanella'] | 26,738,031 | [['E05.601.043'], ['E05.301'], ['E07.305.250'], ['G02.111.248', 'G03.295.531.403', 'G03.493.350'], ['H01.158.273.540.274', 'N06.850.425'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['B03.440.450.690', 'B03.660.250.021.755']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Wall shear stress and early atherosclerotic lesions in the abdominal aorta in young adults. | OBJECTIVES: To study the correlation between wall shear stress and early atherosclerotic lesions in the abdominal aorta.DESIGN: Blinded histomorphometric studies. Comparison with in vitro data.MATERIALS: Abdominal aortic haemodynamics were simulated in a realistic pulsatile flow model. Abdominal aortas from 10 young ad... | ['Adolescent', 'Adult', 'Aging', 'Algorithms', 'Aorta, Abdominal', 'Aortic Diseases', 'Arteriosclerosis', 'Cadaver', 'Female', 'Hemodynamics', 'Hemorheology', 'Humans', 'Laser-Doppler Flowmetry', 'Linear Models', 'Male', 'Models, Cardiovascular', 'Physical Exertion', 'Pulsatile Flow', 'Rest', 'Single-Blind Method', 'St... | 9,166,266 | [['M01.060.057'], ['M01.060.116'], ['G07.345.124'], ['G17.035', 'L01.224.050'], ['A07.015.114.056.205'], ['C14.907.109'], ['C14.907.137.126'], ['C23.550.260.224'], ['G09.330.380'], ['E05.830.250', 'G09.188.370', 'G09.330.380.630'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.370.475', 'E05.830.500'], ['E... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 0 |
Matrix-free single-cell LDI-MS investigations of the diatoms Coscinodiscus granii and Thalassiosira pseudonana. | Single-cell investigations of the diatoms Coscinodsicus granii and Thalassiosira pseudonana were performed using laser desorption/ionization (LDI)-MS without the addition of chemical matrices. The unique cell wall architecture of these microalgae, more precisely the biomineralized nanostructured surface, supported the ... | ['Diatoms', 'Mass Spectrometry', 'Molecular Imaging', 'Nanostructures'] | 24,677,306 | [['B01.750.200'], ['E05.196.566'], ['E01.370.350.557', 'E05.601.555'], ['J01.637.512']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Whole-genome chromatin profiling from limited numbers of cells using nano-ChIP-seq. | Chromatin immunoprecipitation (ChIP) combined with high-throughput sequencing (ChIP-seq) has become the gold standard for whole-genome mapping of protein-DNA interactions. However, conventional ChIP protocols necessitate the use of large numbers of cells, and library preparation steps associated with current high-throu... | ['Animals', 'Cells, Cultured', 'Chromatin Immunoprecipitation', 'Gene Library', 'Genome', 'Genomics', 'Hematopoietic Stem Cells', 'Mice', 'Nanotechnology', 'Sequence Analysis, DNA', 'Stem Cells'] | 21,959,244 | [['B01.050'], ['A11.251'], ['E05.393.170', 'E05.478.605.160'], ['G05.360.325'], ['G05.360.340'], ['H01.158.273.180.350', 'H01.158.273.343.350'], ['A11.148.378', 'A11.872.378', 'A15.378.316.378'], ['B01.050.150.900.649.313.992.635.505.500'], ['H01.603', 'J01.897.520.600'], ['E05.393.760.700'], ['A11.872']] | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Concurrent radiotherapy and continuous ambulatory infusion 5-fluorouracil in advanced head and neck cancer. | Patients with locally advanced stage 3 or 4 recurrent squamous cell carcinoma of the head and neck received 5-fluorouracil (5-FU) 200 or 300 mg/m2/day by prolonged ambulatory infusion concomitantly with radiotherapy (60-66 Gy) to the primary site and neck nodes in 30-33 fractions at five fractions per week, boosting to... | ['Adult', 'Aged', 'Ambulatory Care', 'Antimetabolites, Antineoplastic', 'Carcinoma, Squamous Cell', 'Combined Modality Therapy', 'Drug Administration Schedule', 'Female', 'Fluorouracil', 'Follow-Up Studies', 'Head and Neck Neoplasms', 'Humans', 'Infusion Pumps, Implantable', 'Infusions, Intravenous', 'Male', 'Middle Ag... | 8,664,036 | [['M01.060.116'], ['M01.060.116.100'], ['E02.760.106', 'N02.421.585.106'], ['D27.505.519.186.144', 'D27.505.954.248.144', 'D27.888.569.042.030'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['E02.186'], ['E02.319.283'], ['D03.383.742.698.875.404'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Characterization of a developing lumbar arthrodesis in a sheep model with quantitative instability. | BACKGROUND CONTEXT: Mechanical forces have been considered responsible for stress shielding an arthrodesis, but the biology of a developing lumbar fusion has not been well characterized.PURPOSE: A large animal model was used to test the hypothesis that mechanical forces modify the biological processes involved in a dev... | ['Animals', 'Arthrodesis', 'Biomechanical Phenomena', 'Bone Screws', 'Cartilage', 'Female', 'Immobilization', 'Joint Instability', 'Lumbar Vertebrae', 'Models, Animal', 'Osteogenesis', 'Radiography', 'Sheep', 'Time Factors'] | 14,589,474 | [['B01.050'], ['E04.555.100'], ['G01.154.090', 'G01.374.089'], ['E07.695.370.437', 'E07.858.442.660.460.437', 'E07.858.690.725.460.437'], ['A02.165', 'A10.165.382'], ['E05.472'], ['C05.550.521'], ['A02.835.232.834.519'], ['E05.598'], ['G07.345.500.325.377.625.050.500.729', 'G11.427.578.050.500.729'], ['E01.370.350.700'... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Reaching out to retirees. | The numbers pertaining to the approaching demographic boom in health-care-related expenditures are eye-popping: Health-related financial products to help retiring baby boomers deal with out-of-pocket costs alone will generate up to 80 billion dollars in revenues and 8-12 billion dollars in pre-tax profits by 2014. But ... | ['Health Services Needs and Demand', 'Humans', 'Insurance Benefits', 'Insurance, Health', 'Marketing', 'Retirement'] | 17,175,739 | [['N03.349.380.420', 'N05.300.450'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.219.521.576.130'], ['N03.219.521.576.343'], ['J01.219.687'], ['I03.702']] | ['Health Care [N]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 |
Biphasic effects of dexamethasone on glycogen metabolism in primary cultured rat hepatocytes. | Glucocorticoids (GC), the basic function of which is modulating carbohydrates metabolism, play a critical role in stress response by enhancing the organism's resistance. It is widely believed that they could promote glycogen synthesis. However, it is doubtful whether GC can still stimulate glycogen deposition in stress... | ['Animals', 'Cells, Cultured', 'Cycloheximide', 'Dexamethasone', 'Glucocorticoids', 'Hepatocytes', 'Liver Glycogen', 'Male', 'Rats', 'Rats, Sprague-Dawley'] | 20,009,502 | [['B01.050'], ['A11.251'], ['D03.383.621.808.240'], ['D04.210.500.745.432.769.344', 'D04.210.500.908.238'], ['D06.472.040.543', 'D27.505.696.399.472.488'], ['A11.436.348'], ['D05.750.078.562.388.518', 'D09.698.365.388.518'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.750']] | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Increasing degrees of left ventricular filling impairment modulate left atrial function in humans. | We sought to investigate the changes in atrial reservoir, pump, and conduit functions that are associated with increasing degrees of left ventricular filling impairment. In 13 patients with an impaired relaxation type of filling and in 15 with restrictive patterns, the left atrial volume curve was constructed combining... | ['Adult', 'Blood Flow Velocity', 'Cardiac Catheterization', 'Cardiac Volume', 'Echocardiography, Doppler', 'Heart Atria', 'Heart Ventricles', 'Humans', 'Middle Aged', 'Mitral Valve', 'Myocardial Contraction', 'Pulmonary Veins', 'Reproducibility of Results', 'Stroke Volume', 'Ventricular Dysfunction, Left', 'Video Recor... | 9,761,086 | [['M01.060.116'], ['E01.370.370.130', 'G09.330.380.630.080'], ['E01.370.370.380.140', 'E02.148.442', 'E05.157.250'], ['G09.330.380.249'], ['E01.370.350.130.750.220', 'E01.370.350.850.220.220', 'E01.370.350.850.850.220', 'E01.370.370.380.220.220'], ['A07.541.358'], ['A07.541.560'], ['B01.050.150.900.649.313.988.400.112.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Health Care [N]', 'Diseases [C]', 'Information Science [L]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
A randomized study evaluating cinacalcet to treat hypercalcemia in renal transplant recipients with persistent hyperparathyroidism. | Persistent hyperparathyroidism (HPT) after kidney transplantation (KTx) is associated with hypercalcemia, hypophosphatemia and abnormally high levels of parathyroid hormone (PTH). In this randomized trial, cinacalcet was compared to placebo for the treatment of hypercalcemia in adult patients with persistent HPT after ... | ['Adult', 'Bone Density', 'Bone Remodeling', 'Calcium', 'Cinacalcet', 'Double-Blind Method', 'Female', 'Humans', 'Hypercalcemia', 'Hyperparathyroidism', 'Kidney Transplantation', 'Male', 'Middle Aged', 'Naphthalenes', 'Phosphorus', 'Placebos'] | 25,225,081 | [['M01.060.116'], ['G11.427.100'], ['G11.427.213', 'G16.762.150'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D02.455.426.559.847.638.183', 'D04.615.638.183'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C18.452.1... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The effect of heparin and EDTA on the NBT test. | Heparin precipitates nitroblue tetrazolium (NBT) in the absence of protein (plasma). This NBT-heparin precipitate, when presented to neutrophils, results in NBT scores higher than those obtained with NBT in solution. It is postulated that the high NBT scores obtained with increasing heparin concentrations are due to in... | ['Bacterial Infections', 'Blood Bactericidal Activity', 'Edetic Acid', 'Heparin', 'Humans', 'In Vitro Techniques', 'Neutrophils', 'Nitroblue Tetrazolium', 'Phagocytosis', 'Spectrophotometry, Atomic', 'Tetrazolium Salts'] | 805,817 | [['C01.150.252'], ['G09.188.100', 'G12.450.564.204'], ['D02.092.782.258.368.250', 'D02.241.081.018.253'], ['D09.698.373.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.481'], ['A11.118.637.415.583', 'A11.627.340.583', 'A11.733.689', 'A15.145.229.637.415.583', 'A15.382.490.315.583', 'A15.382.680.689'], ['D... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Exploration of older and younger British adults' performance on The Awareness of Social Inference Test (TASIT). | BACKGROUND: Social perception is an important skill. One assessment that is commonly used to assess social perception abilities is The Awareness of Social Inference Test (TASIT). The only normative data available for this test are for Australian younger adults. Despite no normative data being available for British adul... | ['Adult', 'Aged', 'Aged, 80 and over', 'Australia', 'Awareness', 'Female', 'Humans', 'Male', 'Middle Aged', 'Social Perception', 'Young Adult'] | 27,074,887 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['Z01.639.100', 'Z01.678.100.373'], ['F02.463.188.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['F02.463.593.752'], ['M01.060.116.815']] | ['Named Groups [M]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
Editing the Sickle Cell Disease Mutation in Human Hematopoietic Stem Cells: Comparison of Endonucleases and Homologous Donor Templates. | Site-specific correction of a point mutation causing a monogenic disease in autologous hematopoietic stem and progenitor cells (HSPCs) can be used as a treatment of inherited disorders of the blood cells. Sickle cell disease (SCD) is an ideal model to investigate the potential use of gene editing to transvert a single ... | ['Anemia, Sickle Cell', 'CRISPR-Cas Systems', 'Endonucleases', 'Gene Editing', 'Gene Expression', 'Gene Targeting', 'Genetic Therapy', 'Genetic Vectors', 'Hematopoietic Stem Cells', 'Humans', 'Mutation', 'Parvovirinae', 'Tissue Donors', 'Transduction, Genetic', 'Zinc Finger Nucleases', 'beta-Globins'] | 31,178,391 | [['C15.378.071.141.150.150', 'C15.378.420.155', 'C16.320.070.150', 'C16.320.365.155'], ['G05.308.203.374.394'], ['D08.811.277.352.355'], ['E05.393.420.270'], ['G05.297'], ['E05.393.335'], ['E02.095.301', 'E05.393.420.301'], ['G05.360.337'], ['A11.148.378', 'A11.872.378', 'A15.378.316.378'], ['B01.050.150.900.649.313.98... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Named Groups [M]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Intraoperative spine ultrasound: application and benefits. | PURPOSE: Intraoperative ultrasound (IUS) has been described in numerous papers as an effective tool for spinal tumor resection, degenerative lesions and Chiari malformation surgery, but has not been routinely adopted by spine surgeons. We herein describe our experience with routine IUS application.METHODS: In 2011, the... | ['Adult', 'Aged', 'Arnold-Chiari Malformation', 'Humans', 'Intraoperative Care', 'Male', 'Neurosurgical Procedures', 'Orthopedic Procedures', 'Retrospective Studies', 'Spinal Cord Compression', 'Spinal Neoplasms', 'Spine', 'Ultrasonography'] | 26,342,702 | [['M01.060.116'], ['M01.060.116.100'], ['C10.500.680.291', 'C16.131.666.680.291'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.760.731.400', 'E04.604.249', 'N02.421.585.722.400'], ['E04.525'], ['E02.718', 'E04.555'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.7... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Effects of Tyr-D-Arg-Phe-beta-Ala-NH2, a novel dermorphin analog, on elevated plus-maze learning and spontaneous alternation performance in mice. | 1. The effects of intracerebroventricular administration of Tyr-D-Arg-Phe-beta-Ala-NH2 (TAPA), a novel dermorphin analog, on plus-maze learning and spontaneous alternation performance were investigated in mice. 2. The pre- or posttraining or preretention administration of TAPA (0.3-3.0 ng) alone failed to affect transf... | ['Analgesics, Opioid', 'Animals', 'Behavior, Animal', 'Exploratory Behavior', 'Injections, Intraventricular', 'Male', 'Maze Learning', 'Memory', 'Mice', 'Mice, Inbred Strains', 'Naltrexone', 'Narcotic Antagonists', 'Oligopeptides', 'Opioid Peptides'] | 9,378,255 | [['D27.505.696.277.600.500', 'D27.505.696.663.850.014.760.500', 'D27.505.954.427.040.550.500', 'D27.505.954.427.210.600.500'], ['B01.050'], ['F01.145.113'], ['F01.145.387', 'F01.658.370'], ['E02.319.267.530.550'], ['F02.463.425.874.500'], ['F02.463.425.540'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.1... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Total Synthesis of Dansylated Park's Nucleotide for High-Throughput MraY Assays. | The membrane protein translocase I (MraY) is a key enzyme in bacterial peptidoglycan biosynthesis. It is therefore frequently discussed as a target for the development of novel antibiotics. The screening of compound libraries for the identification of MraY inhibitors is enabled by an established fluorescence-based MraY... | ['Anti-Bacterial Agents', 'Bacterial Proteins', 'Escherichia coli', 'Nucleotides', 'Transferases'] | 27,791,327 | [['D27.505.954.122.085'], ['D12.776.097'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D09.408.620', 'D13.695'], ['D08.811.913']] | ['Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Zinc delays clot lysis by attenuating plasminogen activation and plasmin-mediated fibrin degradation. | Zinc circulates free in plasma at a concentration of 0.1-2 µM, but its levels increase locally when it is released from activated platelets. Although zinc influences many processes in haemostasis, its effect on fibrinolysis has not been thoroughly investigated. Using a fluorescent zinc-binding probe, we demonstrated th... | ['Blood Platelets', 'Catalysis', 'Enzyme Activation', 'Fibrin', 'Fibrinolysin', 'Fibrinolysis', 'Humans', 'Kinetics', 'Plasminogen', 'Platelet Activation', 'Protein Binding', 'Proteolysis', 'Spectrometry, Fluorescence', 'Surface Plasmon Resonance', 'Tissue Plasminogen Activator', 'Trypsin', 'Zinc'] | 25,789,495 | [['A11.118.188', 'A15.145.229.188'], ['G02.130'], ['G02.111.263', 'G03.328'], ['D12.776.124.270'], ['D08.811.277.656.300.760.330', 'D08.811.277.656.959.350.330'], ['G09.188.390.150.390'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.374.661', 'G02.111.490'], ['D08.622.610', 'D12.776.124.790.223.580', 'D12.776... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A critical review of the surgical treatment of congenital proximal radio-ulnar synostosis. | Twenty-two patients for a total of 26 synostoses submitted to surgical treatment at the Rizzoli Orthopaedic Institute were evaluated. Following a critical analysis of the results obtained with various methods of surgical correction, the authors propose what they believe to be the best types of treatment for this rare d... | ['Adolescent', 'Child', 'Child, Preschool', 'Evaluation Studies as Topic', 'Female', 'Humans', 'Male', 'Osteotomy', 'Pronation', 'Radius', 'Retrospective Studies', 'Synostosis', 'Ulna'] | 3,451,916 | [['M01.060.057'], ['M01.060.406'], ['M01.060.406.448'], ['E05.337', 'N05.715.360.335'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.555.580'], ['G11.427.410.698.840'], ['A02.835.232.087.090.700'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.8... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Wound healing and T-lymphocytes. | T-cell depletion leads to impaired wound healing. We studied the effect of combined T-helper and T-suppressor lymphocyte depletion on wound healing and compared it with the effect of all T-cell depletion. Groups of 10 male balb/c mice, 8 weeks old, underwent a 2.5-cm skin incision and subcutaneous implantation of polyv... | ['Animals', 'Antibodies, Monoclonal', 'Mice', 'Mice, Inbred Strains', 'T-Lymphocytes', 'Time Factors', 'Wound Healing'] | 2,352,421 | [['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520', 'B01.050.150.900.649.313.992.635.505.500.400'], ['A11.118.637.555.567.569', 'A15.145.229.637.555.567.569', 'A15.382.490.555.567.569'], ['G... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Study of the DNA content by flow cytometry and proliferation in 281 brain tumors. | In this paper we investigate the distribution of DNA ploidy as well as proliferation rate (S phase of the cell cycle Ki-67 staining) in 281 tumors of the central and peripheral nervous system (87 meningiomas, 75 astrocytomas, 44 nerve sheath tumors, 25 brain metastases, 18 pituitary adenomas, 17 ependymomas, 12 oligode... | ['Adenoma', 'Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Brain Neoplasms', 'Cell Division', 'Child', 'Child, Preschool', 'DNA, Neoplasm', 'Flow Cytometry', 'Glioma', 'Humans', 'Meningeal Neoplasms', 'Meningioma', 'Middle Aged', 'Nerve Sheath Neoplasms', 'Pituitary Neoplasms', 'Ploidies', 'Predictive Value of Te... | 9,075,781 | [['C04.557.470.035'], ['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['M01.060.406'], ['M01.060.406.448'], ['D13.444.308.425'], ['E01.370.225.500.363.... | ['Diseases [C]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
SPECT quantification of benzodiazepine receptor concentration using a dual-ligand approach. | UNLABELLED: The distribution of benzodiazepine receptors in the human brain has been widely studied with SPECT using (123)I-iomazenil and semiquantitative approaches, but these methods do not allow quantification of the total receptor site concentration available for binding (B'(max)) and of the apparent equilibrium di... | ['Adult', 'Female', 'Flumazenil', 'Humans', 'Image Processing, Computer-Assisted', 'Ligands', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Models, Theoretical', 'Positron-Emission Tomography', 'Receptors, GABA-A', 'Tomography, Emission-Computed, Single-Photon'] | 16,644,748 | [['M01.060.116'], ['D03.633.100.079.080.070.305'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['D27.720.470.480'], ['E01.370.350.825.500'], ['M01.060.116.630'], ['E05.599'], ['E01.370.350.350.800.700', 'E01.370.350.600.350.800.399', 'E01.370.350.710.800.399', 'E01.370.350.825.800.399', 'E01.370.3... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Urinary 2-hydroxyestrone/16alpha-hydroxyestrone ratio and risk of breast cancer in postmenopausal women. | BACKGROUND: It has been suggested that women who metabolize a larger proportion of their endogenous estrogen via the 16alpha-hydroxylation pathway may be at elevated risk of breast cancer compared with women who metabolize proportionally more estrogen via the 2-hydroxylation pathway. However, the supporting epidemiolog... | ['Aged', 'Breast Neoplasms', 'Case-Control Studies', 'Female', 'Humans', 'Hydroxyestrones', 'Immunoenzyme Techniques', 'Middle Aged', 'Odds Ratio', 'Postmenopause', 'Radioimmunoassay', 'Risk', 'Risk Factors', 'Steroid 16-alpha-Hydroxylase'] | 10,379,970 | [['M01.060.116.100'], ['C04.588.180', 'C17.800.090.500'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.455.426.559.389.657.166.350.350', 'D04.210.500.365.415.414.400', 'D04.210.500.578.502.497.400', 'D06.472.334.851.437.984.350'], ... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Visible and Extended Near-Infrared Multispectral Imaging for Skin Cancer Diagnosis. | With the goal of diagnosing skin cancer in an early and noninvasive way, an extended near infrared multispectral imaging system based on an InGaAs sensor with sensitivity from 995 nm to 1613 nm was built to evaluate deeper skin layers thanks to the higher penetration of photons at these wavelengths. The outcomes of thi... | ['Algorithms', 'Humans', 'Image Processing, Computer-Assisted', 'Infrared Rays', 'Light', 'Melanoma', 'Optical Imaging', 'Skin Neoplasms'] | 29,734,747 | [['G17.035', 'L01.224.050'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['G01.358.500.505.650.552', 'G01.590.540.552', 'G01.750.250.650.552', 'G01.750.770.578.552', 'G16.500.275.063.725.525.400', 'G16.500.750.775.525.400', 'N06.230.300.100.725.525.400'], ['G01.358.500.505.650', 'G01.590.540', 'G0... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Health Care [N]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Changes in lysosomal morphology and enzyme activities during the development of adriamycin-induced cardiomyopathy. | Morphologic and enzymic changes in heart lysosomes were studied following a chronic treatment of animals with a cumulative dose of 15 mg/kg of adriamycin. Myocardial cell damage due to adriamycin included lysosomal changes, sarcotubular swelling, vacuolization and myofibrillar drop-out. These structural changes were mo... | ['Acetylglucosaminidase', 'Acid Phosphatase', 'Animals', 'Cardiomyopathies', 'Doxorubicin', 'Lysosomes', 'Male', 'Mannosidases', 'Myocardium', 'Rats', 'Rats, Inbred Strains', 'beta-Galactosidase'] | 3,931,886 | [['D08.811.277.450.483.180.500'], ['D08.811.277.352.650.025'], ['B01.050'], ['C14.280.238'], ['D02.455.426.559.847.562.050.200.175', 'D04.615.562.050.200.175', 'D09.408.051.059.200.175'], ['A11.284.430.214.190.875.190.550'], ['D08.811.277.450.625'], ['A02.633.580', 'A07.541.704', 'A10.690.552.750'], ['B01.050.150.900.6... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The changing face of P300 BCIs: a comparison of stimulus changes in a P300 BCI involving faces, emotion, and movement. | BACKGROUND: One of the most common types of brain-computer interfaces (BCIs) is called a P300 BCI, since it relies on the P300 and other event-related potentials (ERPs). In the canonical P300 BCI approach, items on a monitor flash briefly to elicit the necessary ERPs. Very recent work has shown that this approach may y... | ['Adult', 'Brain-Computer Interfaces', 'Electroencephalography', 'Emotions', 'Event-Related Potentials, P300', 'Facial Expression', 'Female', 'Humans', 'Male', 'Motion', 'Photic Stimulation', 'Reproducibility of Results', 'Young Adult'] | 23,189,154 | [['M01.060.116'], ['E07.305.076'], ['E01.370.376.300', 'E01.370.405.245'], ['F01.470'], ['G07.265.216.500.350', 'G11.561.200.500.350'], ['E01.370.600.225', 'F01.145.209.530.385'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.482'], ['E05.723.729'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N0... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Photoperiodic regulation of seasonal testicular regression in the wild European rabbit (Oryctolagus cuniculus). | Adult male wild rabbits were exposed to artificial daylengths of 8L:16D, 13L:11D or 20L:4D after being taken from the wild during September, when testicular size was minimal. In all groups the testes grew and those in 20L:4D grew more quickly than did those in 8L:16D or 13L:11D. Rabbits kept in the 3 daylength treatmen... | ['Animals', 'Follicle Stimulating Hormone', 'Light', 'Male', 'Organ Size', 'Rabbits', 'Seasons', 'Testis'] | 3,090,243 | [['B01.050'], ['D06.472.699.322.576.288', 'D06.472.699.631.525.343.288', 'D12.644.548.691.525.343.288'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['E01.370.600.115.100.660', 'E05.041.124.715', 'G07.100.100.660', 'G07.345.249.690'], ['B01.050.150.900.649.313.968.700'], ['G01.910.645.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
The reproductive and developmental toxicity of High Flash Aromatic Naphtha. | Catalytic reforming is a refining process that converts naphthenes to aromatics by dehydrogenation to make higher octane gasoline blending components. A portion of this wide boiling range hydrocarbon stream can be separated by distillation and used for other purposes. One such application is a mixture of predominantly ... | ['Administration, Inhalation', 'Animals', 'Body Weight', 'Embryonic and Fetal Development', 'Female', 'Fertility', 'Hydrocarbons', 'Mice', 'Organ Size', 'Pregnancy', 'Prenatal Exposure Delayed Effects', 'Rats', 'Reproduction', 'Teratogens'] | 2,237,929 | [['E02.319.267.050'], ['B01.050'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['G07.345.500.325', 'G08.686.784.170'], ['G08.686.210'], ['D02.455'], ['B01.050.150.900.649.313.992.635.505.500'], ['E01.370.600.115.100.660', 'E05.041.124.715', 'G07.1... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Evaluation of biological nutrient removal from wastewater by Twin Circulating Fluidized Bed Bioreactor (TCFBBR) using a predictive fluidization model and AQUIFAS APP. | A two-phase and three-phase predictive fluidization model based on the characteristics of a system such as media type and size, flow rates, and reactor cross sectional area was proposed to calculate bed expansion, solid, liquid and gas hold up and specific surface area (SSA) of the biofilm particles. The model was subs... | ['Bioreactors', 'Computer Simulation', 'Equipment Design', 'Equipment Failure Analysis', 'Industrial Waste', 'Models, Biological', 'Rheology', 'Water Microbiology'] | 21,075,620 | [['E07.115', 'J01.897.120.115'], ['L01.224.160'], ['E05.320'], ['E05.325.192'], ['D20.944.420', 'N06.850.460.710.420'], ['E05.599.395'], ['E05.830', 'H01.671.808'], ['H01.158.273.540.274.777', 'N06.850.425.450']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 |
Long-term efavirenz use is associated with worse neurocognitive functioning in HIV-infected patients. | Neurocognitive (NC) complications continue to afflict a substantial proportion of HIV-infected people taking effective antiretroviral therapy (ART). One contributing mechanism for this is antiretroviral neurotoxicity. Efavirenz (EFV) is associated with short-term central nervous system (CNS) toxicity, but less is known... | ['Adult', 'Alkynes', 'Anti-HIV Agents', 'Benzoxazines', 'CD4 Lymphocyte Count', 'CD4-Positive T-Lymphocytes', 'Cognitive Dysfunction', 'Coinfection', 'Cyclopropanes', 'Drug Therapy, Combination', 'Executive Function', 'Female', 'HIV Infections', 'HIV-1', 'Hepacivirus', 'Hepatitis C', 'Humans', 'Lopinavir', 'Male', 'Mem... | 26,407,716 | [['M01.060.116'], ['D02.455.326.397'], ['D27.505.954.122.388.077.088'], ['D03.383.533.249', 'D03.633.100.209'], ['E01.370.225.500.195.107.595.500.150', 'E01.370.225.625.107.595.500.150', 'E05.200.500.195.107.595.500.150', 'E05.200.625.107.595.500.150', 'E05.242.195.107.595.500.150', 'G04.140.107.595.500.150', 'G09.188.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Partial FI gene-independence of lambda-21 hybrid phages specifying chimeric terminases. | The role of the FI gene in the life cycles of a series of lambda-21 hybrid phages that produce chimeric lambda-21 terminases has been examined. An isogenic series of FI+ and FI- derivatives of the hybrids was constructed, and the growth properties of the phages were examined. It was found that three of the four hybrids... | ['Bacteriophage lambda', 'Chimera', 'Endodeoxyribonucleases', 'Genes, Viral', 'Mutation'] | 2,973,176 | [['B04.123.150.800.230', 'B04.123.205.230', 'B04.280.090.800.230'], ['B05.200'], ['D08.811.277.352.335.350', 'D08.811.277.352.355.325'], ['G05.360.340.024.340.364.875', 'G05.360.340.358.024.875', 'G05.360.340.358.840.500'], ['G05.365.590']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Interdigital pilonidal sinus of the foot. | Pilonidal sinus of the interdigital spaces is a common condition among barbers. The condition results from a foreign body reaction to clients' hairs. It is thought that the short sharp hairs penetrate the skin when hands are rubbed through freshly cut hair. We present an unusual case of a pilonidal sinus arising in the... | ['Adult', 'Beauty Culture', 'Female', 'Foot Diseases', 'Humans', 'Occupational Diseases', 'Pilonidal Sinus'] | 20,307,483 | [['M01.060.116'], ['J01.576.112'], ['C05.360', 'C17.800.321'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C24'], ['C04.182.710']] | ['Named Groups [M]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 |
Phantasy therapy: statistical evaluation of a new approach to group psychotherapy for stationary and ambulatory psychotic patients. | BACKGROUND: Since 1995 we have developed a depth-psychological, experience- and expression-oriented approach to group therapy for psychotic patients--"Phantasy Therapy"--complementary to the main-stream emphasis upon behavioural, learn- and goal-oriented methods.AIMS: A group psychotherapy for acute and remitting patie... | ['Adult', 'Art Therapy', 'Fantasy', 'Female', 'Humans', 'Male', 'Middle Aged', 'Psychotherapy, Group', 'Psychotic Disorders', 'Schizophrenia', 'Treatment Outcome'] | 17,848,798 | [['M01.060.116'], ['E02.190.888.124', 'E02.760.169.063.500.100', 'E02.831.100', 'F04.754.070'], ['F01.393.351', 'F02.463.188.634.507'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['F04.754.864.581'], ['F03.700.675'], ['F03.700.750'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Maximal shortening velocity during plantar flexion: Effects of pre-activity and initial stretching state. | We investigated the effects of the initial length of the muscle-tendon unit (MTU) and muscle pre-activation on muscle-tendon interactions during plantarflexion performed at maximal velocity. Ultrasound images of gastrocnemius medialis were obtained on 11 participants in three conditions: (a) active plantarflexion perfo... | ['Adult', 'Ankle Joint', 'Biomechanical Phenomena', 'Humans', 'Isometric Contraction', 'Male', 'Muscle, Skeletal', 'Range of Motion, Articular', 'Tendons', 'Ultrasonography', 'Young Adult'] | 29,274,183 | [['M01.060.116'], ['A02.835.583.378.062'], ['G01.154.090', 'G01.374.089'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G11.427.494.472'], ['A02.633.567', 'A10.690.552.500'], ['E01.370.600.700', 'G11.427.760'], ['A02.880'], ['E01.370.350.850'], ['M01.060.116.815']] | ['Named Groups [M]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Problem solving as a core strategy in the prevention of schizophrenia and other mental disorders. | OBJECTIVE: To outline the rationale for implementing training in structured problem solving as a primary prevention strategy for major mental disorders.METHOD: The evidence that training people in a structured method of solving their personal problems is an effective strategy in the treatment of established cases of sc... | ['Adolescent', 'Adult', 'Bipolar Disorder', 'Child', 'Depressive Disorder, Major', 'Humans', 'Patient Care Team', 'Pilot Projects', 'Problem Solving', 'Schizophrenia', 'Schizophrenic Psychology'] | 11,129,306 | [['M01.060.057'], ['M01.060.116'], ['F03.084.500'], ['M01.060.406'], ['F03.600.300.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N04.590.715'], ['E05.318.372.750', 'E05.337.737', 'N05.715.360.330.720', 'N06.850.520.450.720'], ['F02.463.425.725', 'F02.463.785.810'], ['F03.700.750'], ['F04.824']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Prevalence of dermatological complaints in patients undergoing treatment for breast cancer. | BACKGROUND: Internal malignancies such as breast cancer, as well as their treatment can often result in skin changes.OBJECTIVE: To assess the prevalence of dermatological complaints in patients who are undergoing oncological treatment for breast cancer in a hospital in Tubar?o, Santa Catarina, Brazil.METHODS: Observati... | ['Adolescent', 'Adult', 'Aged', 'Antineoplastic Agents', 'Brazil', 'Breast Neoplasms', 'Cross-Sectional Studies', 'Female', 'Hormones', 'Humans', 'Middle Aged', 'Prevalence', 'Skin', 'Skin Diseases', 'Socioeconomic Factors', 'Young Adult'] | 29,924,229 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.248'], ['Z01.107.757.176'], ['C04.588.180', 'C17.800.090.500'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['D06.472', 'D27.505.696.399.472'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], [... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Extraocular muscle function in adult-onset Pompe disease tested by saccadic eye movements. | Glycogen storage disease type II (Pompe disease) affects mainly proximal skeletal muscles. Despite older histological evidence of extraocular muscle involvement, ocular motor palsies or other eye movement abnormalities are not considered part of the clinical picture. We investigated the dynamics of saccadic eye movemen... | ['Adult', 'Age of Onset', 'Aged', 'Eye Movement Measurements', 'Female', 'Glycogen Storage Disease Type II', 'Humans', 'Infrared Rays', 'Male', 'Middle Aged', 'Oculomotor Muscles', 'Saccades', 'Severity of Illness Index'] | 25,260,626 | [['M01.060.116'], ['N05.715.350.075.100', 'N06.850.490.250.100'], ['M01.060.116.100'], ['E01.370.380.230', 'E01.370.405.245.787'], ['C10.228.140.163.100.435.340', 'C16.320.565.189.435.340', 'C16.320.565.202.449.500', 'C16.320.565.595.554.340', 'C18.452.132.100.435.340', 'C18.452.648.189.435.340', 'C18.452.648.202.449.5... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Surviving a Genome Collision: Genomic Signatures of Allopolyploidization in the Recent Crop Species Brassica napus | Polyploidization has played a major role in crop plant evolution, leading to advantageous traits that have been selected by humans. Here, we describe restructuring patterns in the genome of L., a recent allopolyploid species. Widespread segmental deletions, duplications, and homeologous chromosome exchanges were identi... | ['Base Pair Mismatch', 'Brassica napus', 'Chromosomal Instability', 'Chromosomes, Plant', 'Crops, Agricultural', 'DNA Copy Number Variations', 'Genome, Plant', 'Meiosis', 'Polymorphism, Single Nucleotide', 'Polyploidy', 'Recombination, Genetic'] | 29,293,818 | [['G05.365.590.060'], ['B01.650.940.800.575.912.250.157.200.249'], ['C23.550.210.110', 'C23.550.362.180', 'G05.365.590.175.165', 'G05.370.180'], ['A11.284.187.560', 'A18.005', 'G05.360.162.560'], ['B01.650.160', 'G07.203.300.300', 'J02.500.300'], ['G05.365.795.297.500'], ['G05.360.340.365'], ['G04.144.220.220.687', 'G0... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Effect of chlorpromazine on kinetics of injected monoclonal antibody in MoAb-induced glomerular injury. | The effect of chlorpromazine, one of several calmodulin antagonists that inhibit cytoskeletal movement, on the local kinetics of injected proteinuria-inducing MoAb 5-1-6 was examined to test the hypothesis that proteinuria is inhibited if the antigen recognized by MoAb 5-1-6 or injected MoAb remains on the surface of e... | ['Animals', 'Antibodies, Monoclonal', 'Chlorpromazine', 'Female', 'Fluorescent Antibody Technique', 'Glomerulonephritis', 'Microscopy, Immunoelectron', 'Proteinuria', 'Rats', 'Rats, Wistar'] | 8,419,074 | [['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D02.886.369.198', 'D03.633.300.783.198'], ['E01.370.225.500.607.512.240', 'E01.370.225.750.551.512.240', 'E05.200.500.607.512.240', 'E05.200.750.551.512.240', 'E05.478.583.375'], ['C12.777.419.570.363', 'C13.3... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effect of ramipril on ambulatory blood pressure and albuminuria in renal hypertension. | Inhibition of the angiotensin-converting enzyme (ACE) exerts a renoprotective effect in adult patients with chronic kidney disease. We evaluated prospectively changes in blood pressure (BP), protein excretion and renal function after administration of the long-acting ACE inhibitor ramipril as monotherapy during 6 month... | ['Adolescent', 'Adult', 'Albuminuria', 'Angiotensin-Converting Enzyme Inhibitors', 'Blood Pressure', 'Blood Pressure Monitoring, Ambulatory', 'Child', 'Child, Preschool', 'Diastole', 'Female', 'Glomerular Filtration Rate', 'Humans', 'Hypertension, Renal', 'Male', 'Ramipril', 'Systole'] | 11,095,026 | [['M01.060.057'], ['M01.060.116'], ['C12.777.934.734.269', 'C13.351.968.934.734.269', 'C23.888.942.750.269'], ['D27.505.519.389.745.085'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E01.370.370.140.100', 'E01.370.520.500.100'], ['M01.060.406'], ['M01.060.406.448'], ['G09.330.580.295', 'G11.427.494.554.250', 'G11.427... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Renal actions of the selective angiotensin AT2 receptor ligands CGP 42112B and PD 123319 in the sodium-depleted rat. | The purpose of this study was to investigate the renal actions of the new selective angiotensin AT2 receptor ligands, CGP 42112B and PD 123319, in comparison to those of the AT1 receptor antagonist losartan, in the sodium-depleted, anesthetized rat. Losartan (1, 3 and 10 mg/kg i.v.) produced a dose-dependent decrease i... | ['Angiotensin II', 'Angiotensin Receptor Antagonists', 'Animals', 'Biphenyl Compounds', 'Blood Pressure', 'Diet, Sodium-Restricted', 'Glomerular Filtration Rate', 'Imidazoles', 'Kidney', 'Losartan', 'Male', 'Oligopeptides', 'Potassium', 'Pyridines', 'Radioligand Assay', 'Rats', 'Rats, Sprague-Dawley', 'Renal Circulatio... | 8,282,023 | [['D06.472.699.094.078', 'D12.644.400.070.078', 'D12.644.456.073.041', 'D12.644.548.058.078', 'D12.776.631.650.070.078', 'D23.469.050.050.050'], ['D27.505.519.162'], ['B01.050'], ['D02.455.426.559.389.185'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E02.642.249.290', 'G07.203.650.240.290'], ['E01.370.390.400.300', ... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Medieval iconography of watermelons in Mediterranean Europe. | BACKGROUND AND AIMS: The watermelon, Citrullus lanatus (Cucurbitaceae), is an important fruit vegetable in the warmer regions of the world. Watermelons were illustrated in Mediterranean Antiquity, but not as frequently as some other cucurbits. Little is known concerning the watermelons of Mediterranean Europe during me... | ['Books, Illustrated', 'Citrullus', 'Crops, Agricultural', 'Europe', 'History, Medieval', 'Italy', 'Mediterranean Region'] | 23,904,443 | [['J01.897.280.500.117', 'L01.178.682.192.289'], ['B01.650.940.800.575.912.250.300.140'], ['B01.650.160', 'G07.203.300.300', 'J02.500.300'], ['Z01.542'], ['K01.400.500'], ['Z01.542.489'], ['Z01.542.580']] | ['Technology, Industry, and Agriculture [J]', 'Information Science [L]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Humanities [K]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 |
Anosognosia is a significant predictor of apathy in Alzheimer's disease. | Anosognosia and apathy are among the most common behavioral and psychological disorders of Alzheimer's disease and are significantly associated in cross-sectional studies. The aim for this study was to carry out for the first time a longitudinal assessment of this association with the aim of clarifying the predictive r... | ['Aged', 'Agnosia', 'Alzheimer Disease', 'Analysis of Variance', 'Apathy', 'Cross-Sectional Studies', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Middle Aged', 'Predictive Value of Tests', 'Psychiatric Status Rating Scales', 'Retrospective Studies'] | 21,037,121 | [['M01.060.116.100'], ['C10.597.606.762.100', 'C23.888.592.604.764.100', 'F01.700.750.100'], ['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['F01.470.137'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], [... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Dietary flavones counteract phorbol 12-myristate 13-acetate-induced SREBP-2 processing in hepatic cells. | Consumption of fruits and vegetables is generally regarded as beneficial to plasma lipid profile. The mechanism by which the plant foods induce desirable lipid changes remains unclear. SREBP-2 is crucial in cholesterol metabolism, and it is a major regulator of the cholesterol biosynthesis enzyme HMGCR. Our lab has pre... | ['AMP-Activated Protein Kinases', 'Apigenin', 'Dietary Supplements', 'Hep G2 Cells', 'Humans', 'Hydroxymethylglutaryl CoA Reductases', 'Liver', 'Luteolin', 'Sterol Regulatory Element Binding Protein 2', 'Tetradecanoylphorbol Acetate'] | 27,778,136 | [['D08.811.913.696.620.682.700.085', 'D12.644.360.062', 'D12.776.476.062'], ['D03.383.663.283.266.450.260.110', 'D03.633.100.150.266.450.260.110'], ['G07.203.300.456', 'J02.500.456'], ['A11.251.860.180.432', 'A11.436.348.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.682.047.820.150.415'], ['A03.620'... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Osteoinductive Effects of Free and Immobilized Bone Forming Peptide-1 on Human Adipose-Derived Stem Cells. | Most synthetic polymeric materials currently used for bone tissue engineering lack specific signals through which cells can identify and interact with the surface, resulting in incompatibility and compromised osteogenic activity. Soluble inductive factors also have issues including a short half-live in vivo. Bone formi... | ['Adipose Tissue', 'Alkaline Phosphatase', 'Animals', 'Bone Morphogenetic Protein 7', 'Cell Adhesion', 'Cell Differentiation', 'Cell Proliferation', 'Cells, Cultured', 'Core Binding Factor Alpha 1 Subunit', 'Humans', 'Immunohistochemistry', 'Lactic Acid', 'Male', 'Mice, Inbred BALB C', 'Mice, Nude', 'Models, Animal', '... | 26,930,062 | [['A10.165.114'], ['D08.811.277.352.650.035'], ['B01.050'], ['D12.644.276.954.200.700', 'D12.776.467.942.200.700', 'D23.529.942.200.700'], ['G04.022'], ['G04.152'], ['G04.161.750', 'G07.345.249.410.750'], ['A11.251'], ['D12.776.930.155.200.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.51... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Circulating tumor cells as a window on metastasis biology in lung cancer. | Circulating tumor cell (CTC) number in metastatic cancer patients yields prognostic information consistent with enhanced cell migration and invasion via loss of adhesion, a feature of epithelial-to-mesenchymal transition (EMT). Tumor cells also invade via collective migration with maintained cell-cell contacts and cons... | ['Aged', 'Biomarkers, Tumor', 'Cell Survival', 'Epithelial Cells', 'Female', 'Humans', 'Lung Neoplasms', 'Male', 'Mesoderm', 'Middle Aged', 'Neoplasm Metastasis', 'Neoplastic Cells, Circulating'] | 21,356,352 | [['M01.060.116.100'], ['D23.101.140'], ['G04.346'], ['A11.436'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['A16.504.660'], ['M01.060.116.630'], ['C04.697.650', 'C23.550.727.650'], ['A11.642', 'C04.697.650.900', 'C23.550.727.650.900']] | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
HBV infection: prevalence of core antibody and other markers in urban based, black school children in Kenya. | This paper reports a study of 279 sera obtained from children attending five schools in Nairobi, the capital of Kenya which is situated in a non-malarious zone. Their ages ranged from six to 16 years. The surface antigen of hepatitis B virus (HBV) was detected in 13 children (4.7%) including seven boys and six girls. T... | ['Adolescent', 'Child', 'Female', 'Hemagglutination Tests', 'Hepatitis B', 'Hepatitis B Antibodies', 'Hepatitis B Antigens', 'Humans', 'Male', 'Radioimmunoassay'] | 6,200,065 | [['M01.060.057'], ['M01.060.406'], ['E01.370.225.812.735.050.375', 'E05.200.812.735.050.375', 'E05.478.594.760.050.375'], ['C01.221.250.500', 'C01.925.256.430.400', 'C01.925.440.435', 'C06.552.380.705.437'], ['D12.776.124.486.485.114.254.450.504', 'D12.776.124.790.651.114.254.450.504', 'D12.776.377.715.548.114.254.450.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
An embryonic-specific repressor element located 3' to the Agamma-globin gene influences transcription of the human beta-globin locus in transgenic mice. | OBJECTIVE: Persistent expression of the human fetal gamma-globin genes in the adult stage is often associated with naturally occurring deletions in the human beta-globin locus. The mapping of the 5' breakpoints of these deletions within the Agamma- to delta-globin intergenic region has suggested that regulatory element... | ['Animals', 'Chromosome Mapping', 'Embryo, Mammalian', 'Escherichia coli', 'Gene Deletion', 'Gene Expression Regulation, Developmental', 'Globins', 'Humans', 'In Situ Hybridization', 'Mice', 'Mice, Transgenic', 'Recombination, Genetic', 'Repressor Proteins'] | 15,102,485 | [['B01.050'], ['E05.393.183'], ['A16.254'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['G05.365.590.762.320', 'G05.558.800.320'], ['G05.308.310'], ['D12.776.422.316'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.620.670.325', 'E01.370.225.750.600.670.325', 'E05.200.500.620.670.325',... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Ultrasound applicators with internal water-cooling for high-powered interstitial thermal therapy. | Internal water-cooling of direct-coupled ultrasound (US) applicators for interstitial thermal therapy (hyperthermia and coagulative thermal therapy) was investigated. Implantable applicators were constructed using tubular US sources (360 angular acoustic emittance, approximately 7 MHz) of 10 mm length and 1.5, 1.8, 2.2... | ['Acoustics', 'Animals', 'Electrocoagulation', 'Equipment Design', 'Female', 'Liver', 'Muscle, Skeletal', 'Swine', 'Temperature', 'Thigh', 'Transducers', 'Ultrasonic Therapy', 'Water'] | 11,059,170 | [['H01.671.031'], ['B01.050'], ['E02.154.402', 'E04.014.170.402'], ['E05.320'], ['A03.620'], ['A02.633.567', 'A10.690.552.500'], ['B01.050.150.900.649.313.500.880'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.150.450', 'N06.230.300.100.725.710'], ['A01.378.610.750'], ['E07.305.812'], ['E... | ['Disciplines and Occupations [H]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Ion channel events simulated with the program SIMSTATE. | Ion channel transitions between conducting (open) and non-conducting (closed) states are often described in terms of a chemical kinetic model, where the rate constants describing the transitions between states can be derived by analysing a data record and measuring channel dwell times. In this paper, a menu-driven prog... | ['Algorithms', 'Calcium', 'Calcium Channels', 'Computer Simulation', 'Data Display', 'Ion Channel Gating', 'Ion Channels', 'Ion Transport', 'Microcomputers', 'Models, Biological', 'Models, Chemical', 'Models, Theoretical', 'Potassium Channels', 'Software'] | 7,540,964 | [['G17.035', 'L01.224.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D12.776.157.530.400.150', 'D12.776.543.550.450.150', 'D12.776.543.585.400.150'], ['L01.224.160'], ['F02.784.412.221', 'L01.296'], ['G02.111.820.400', 'G04.835.400', 'G07.265.625'], ['D12.776.157.530.400', 'D12.776.543.550.450', 'D12.7... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Red cell ferritin content: a re-evaluation of indices for iron deficiency in the anaemia of rheumatoid arthritis. | In iron deficiency anaemia basic red cell content of ferritin is appreciably reduced. This variable was determined in 62 patients with rheumatoid arthritis to evaluate conventional laboratory indices for iron deficiency in the anaemia of rheumatoid arthritis. For 23 patients with rheumatoid arthritis and normocytic ana... | ['Adolescent', 'Adult', 'Aged', 'Anemia', 'Anemia, Hypochromic', 'Arthritis, Rheumatoid', 'Diagnosis, Differential', 'Erythrocytes', 'Female', 'Ferritins', 'Humans', 'Iron', 'Male', 'Middle Aged'] | 6,434,023 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['C15.378.071'], ['C15.378.071.196'], ['C05.550.114.154', 'C05.799.114', 'C17.300.775.099', 'C20.111.199'], ['E01.171'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['D12.776.157.427.249', 'D12.776.556.579.249'], ['B01.050.150.900.649.313.988.400.112.400.40... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
In vitro and in vivo antiviral activity and resistance profile of the hepatitis C virus NS3/4A protease inhibitor ABT-450. | The development of direct-acting antiviral agents is a promising therapeutic advance in the treatment of hepatitis C virus (HCV) infection. However, rapid emergence of drug resistance can limit efficacy and lead to cross-resistance among members of the same drug class. ABT-450 is an efficacious inhibitor of HCV NS3/4A ... | ['Antiviral Agents', 'Drug Resistance, Viral', 'Hepacivirus', 'Hepatitis C', 'Humans', 'Macrocyclic Compounds', 'Viral Nonstructural Proteins'] | 25,451,053 | [['D27.505.954.122.388'], ['G06.225.420', 'G06.920.225', 'G07.690.773.984.269.420'], ['B04.450.380', 'B04.820.578.344.475'], ['C01.221.250.750', 'C01.925.440.440', 'C01.925.782.350.350', 'C06.552.380.705.440'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D04.345'], ['D12.776.964.900']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Distribution of an L-isoaspartyl protein methyltransferase in eubacteria. | A protein carboxyl methyltransferase (EC 2.1.1.77) that recognizes age-damaged proteins for potential repair or degradation reactions has been found in all vertebrate tissues and cells examined to date. This enzyme catalyzes the transfer of methyl groups from S-adenosylmethionine to the carboxyl groups of D-aspartyl or... | ['Amino Acid Sequence', 'Bacterial Proteins', 'Escherichia coli', 'Genes, Bacterial', 'Gram-Negative Bacteria', 'Gram-Positive Bacteria', 'Molecular Sequence Data', 'Protein D-Aspartate-L-Isoaspartate Methyltransferase', 'Protein Methyltransferases', 'Salmonella typhimurium', 'Sequence Homology, Nucleic Acid', 'Species... | 1,729,230 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D12.776.097'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['G05.360.340.024.340.364.249', 'G05.360.340.358.024.249', 'G05.360.340.358.207.249'], ['B03.440'], ['B03.510'], ['L01.453.245.667'], ['D08.811.913.555.500.800.800.700'], ['D08.811.913.555.500.800'], ['... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
An improved culture medium for mouse blastocysts. | Eagle's basal medium, modified to contain essential amino acids at the concentrations optimal for mouse blastocyst hatching, attachment, and outgrowth, supported in vitro development of the mouse blastocyst better than other tissue culture media tested. This medium was improved for growth and differentiation of the inn... | ['Amino Acids', 'Animals', 'Blastocyst', 'Blood', 'Cell Differentiation', 'Culture Media', 'Culture Techniques', 'Glucose', 'Mercaptoethanol', 'Mice', 'Uridine'] | 7,419,236 | [['D12.125'], ['B01.050'], ['A16.254.500'], ['A12.207.152', 'A15.145'], ['G04.152'], ['D27.720.470.305', 'E07.206'], ['E05.481.500'], ['D09.947.875.359.448'], ['D02.033.375.534', 'D02.886.489.409'], ['B01.050.150.900.649.313.992.635.505.500'], ['D03.383.742.680.852', 'D13.570.685.852', 'D13.570.800.892']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effect of thrombin on proliferation, contraction and prostaglandin production of rat glomerular mesangial cells in culture. | The effect of thrombin on mesangial cell function was investigated. Thrombin caused a dose-dependent increase in [3H] thymidine incorporation (EC50 = 0.36 +/- 0.09 U/ml), intracellular calcium [(Ca++)i] mobilization (EC50 = 1.9 +/- 0.5 U/ml) and prostaglandin E2 (PGE2) production (EC50 = 0.25 +/- 0.02 U/ml) in rat glom... | ['Animals', 'Calcium', 'Cell Division', 'Cells, Cultured', 'Glomerular Mesangium', 'Hirudins', 'Indomethacin', 'Prostaglandins E', 'Rats', 'Rats, Sprague-Dawley', 'Thrombin', 'Thymidine'] | 1,403,802 | [['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.251'], ['A05.810.453.324.359.620.500', 'A05.810.453.736.520.620.500'], ['D12.644.861.060.875', 'D12.776.872.060.875'], ['D03.633.100.473.420'], ['D10.251.355.255.550.250',... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Experimental study of X-ray mammography in a fluid bath: reduced radiation dose and improved detail resolution. | OBJECTIVE: To determine the effects on x-ray mammography of embedding the breast in a fluid bath.METHODS: A plexiglass phantom in the shape of a compressed breast was x-rayed in air and water with a mammography unit, and the radiation dose was measured by 20 thermoluminescence dosimeters placed in 20 representative pos... | ['Air', 'Animals', 'Female', 'Humans', 'Mammary Glands, Animal', 'Mammography', 'Observer Variation', 'Phantoms, Imaging', 'Radiation Dosage', 'Radiographic Image Enhancement', 'Sensitivity and Specificity', 'Sheep', 'Water'] | 10,548,379 | [['G16.500.275.063.150', 'N06.230.300.100.150'], ['B01.050'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A10.336.482', 'A13.589'], ['E01.370.350.700.500'], ['E01.354.753', 'N02.421.450.600', 'N05.715.350.150.675', 'N06.850.490.500.250'], ['E07.671'], ['E05.799.513', 'G01.750.740', 'N06.850.810.250'], ['E01.370.... | ['Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
The association of osteopontin and LMX1A expression with World Health Organization grade in meningiomas and gliomas. | AIMS: Osteopontin (OPN) and LIM homeobox transcription factor 1, alpha (LMX1A) are important factors related to tumour progression, invasion and metastasis in human cancers. The aim of this study was to test the hypothesis that expression of OPN and of LMX1A correlate with the World Health Organization (WHO) grading sy... | ['Brain Neoplasms', 'Disease Progression', 'Glioma', 'Humans', 'Immunohistochemistry', 'LIM-Homeodomain Proteins', 'Meningeal Neoplasms', 'Meningioma', 'Neoplasm Grading', 'Neoplasm Invasiveness', 'Neurocytoma', 'Osteopontin', 'Transcription Factors', 'World Health Organization'] | 22,882,568 | [['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['C23.550.291.656'], ['C04.557.465.625.600.380', 'C04.557.470.670.380', 'C04.557.580.625.600.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.4... | ['Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Attitudes concerning involuntary treatment of mania: results of a survey within self-help organizations. | PURPOSE: - The objective of the study was to determine the level of involuntary treatment that mood disorder patients and their families wish in the event of a manic or hypomanic episode.METHOD: - A survey was conducted within two self-help organizations during two conventions gathering over 500 patients, along with fa... | ['Adult', 'Attitude to Health', 'Bipolar Disorder', 'Coercion', 'Commitment of Mentally Ill', 'Cooperative Behavior', 'Decision Making', 'Family', 'Female', 'Hospitalization', 'Humans', 'Male', 'Patient Advocacy', 'Self-Help Groups', 'Surveys and Questionnaires', 'Treatment Refusal'] | 15,158,922 | [['M01.060.116'], ['F01.100.150', 'N05.300.150'], ['F03.084.500'], ['I01.880.604.316', 'I01.880.630.200'], ['F04.096.544.335.200', 'N03.706.535.351.200'], ['F01.145.813.115'], ['F02.463.785.373'], ['F01.829.263', 'I01.880.853.150'], ['E02.760.400', 'N02.421.585.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Anxiety-related behavioral inhibition in rats: a model to examine mechanisms underlying the risk to develop stress-related psychopathology. | Behavioral inhibition (BI) is an adaptive defensive response to threat; however, children who display extreme BI as a stable trait are at risk for development of anxiety disorders and depression. The present study validates a rodent model of BI based on an ethologically relevant predator exposure paradigm. We show that... | ['Adaptation, Psychological', 'Age Factors', 'Amygdala', 'Analysis of Variance', 'Animals', 'Anxiety', 'Brain', 'Carrier Proteins', 'Defense Mechanisms', 'Disease Models, Animal', 'Female', 'Hippocampus', 'Homer Scaffolding Proteins', 'Inhibition, Psychological', 'Male', 'Mental Disorders', 'Paraventricular Hypothalami... | 20,738,409 | [['F01.058'], ['N05.715.350.075', 'N06.850.490.250'], ['A08.186.211.180.090', 'A08.186.211.200.885.287.249.152'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['B01.050'], ['F01.470.132'], ['A08.186.211'], ['D12.776.157'], ['F01.393'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['A08.186.211.1... | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Absolute dominance of hydrogenotrophic methanogens in full-scale anaerobic sewage sludge digesters. | Anaerobic digestion (AD) is gaining increasing attention due to the ability to covert organic pollutants into energy-rich biogas and, accordingly, growing interest is paid to the microbial ecology of AD systems. Despite extensive efforts, AD microbial ecology is still limitedly understood, especially due to the lack of... | ['Anaerobiosis', 'Bioreactors', 'Euryarchaeota', 'Phylogeny', 'Sewage'] | 24,552,056 | [['G02.111.062', 'G03.078'], ['E07.115', 'J01.897.120.115'], ['B02.200'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['D20.944.932.500']] | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Information Science [L]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Effects of viloxazine, an antidepressant agent, on biogenic amine uptake mechanisms and related activities. | The effects of viloxazine, a clinically effective antidepressant, on noradrenaline (NA) and 5-hydroxytryptamine (5-HT) uptake and various related pharmacological activities were determined and compared to those of the tricyclic antidepressants desimipramine, imipramine, and amitriptyline. Viloxazine inhibitied [3H]NA u... | ['Amitriptyline', 'Animals', 'Apomorphine', 'Biogenic Amines', 'Brain', 'Desipramine', 'Drug Synergism', 'Gastric Juice', 'Imipramine', 'In Vitro Techniques', 'Levodopa', 'Mice', 'Morpholines', 'Myocardium', 'Norepinephrine', 'Oxotremorine', 'Pupil', 'Rats', 'Reflex', 'Reserpine', 'Serotonin', 'Tyramine', 'Viloxazine'] | 974,878 | [['D02.455.426.559.847.181.384.100', 'D04.615.181.384.100'], ['B01.050'], ['D03.132.098.038.290', 'D03.633.100.531.085.030.290', 'D03.633.400.095.290'], ['D02.092.211'], ['A08.186.211'], ['D03.633.300.240.281'], ['G07.690.773.968.477'], ['A12.200.307'], ['D03.633.300.240.485'], ['E05.481'], ['D02.092.311.200.480', 'D02... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Molecular cytogenetics identification of a wheat - Leymus mollis double disomic addition line with stripe rust resistance. | Leymus mollis (Trin.) Pilg. (2n = 4x = 28, NsNsXmXm) possesses a number of valuable genes against biotic and abiotic stress, which could be transferred into common wheat background for wheat improvement. In the present study, we determined the karyotypic constitution of a wheat - L. mollis double disomic addition line,... | ['Basidiomycota', 'Chromosomes, Plant', 'Cytogenetic Analysis', 'Disease Resistance', 'Genome, Plant', 'Hybrid Vigor', 'Hybridization, Genetic', 'In Situ Hybridization', 'In Situ Hybridization, Fluorescence', 'Karyotype', 'Plant Breeding', 'Plant Diseases', 'Poaceae', 'Triticum'] | 28,177,840 | [['B01.300.179'], ['A11.284.187.560', 'A18.005', 'G05.360.162.560'], ['E01.370.225.500.385', 'E05.200.500.385', 'E05.242.385', 'E05.393.285'], ['C23.550.291.671', 'G12.450.564.250', 'G12.450.800.250', 'G15.630.250'], ['G05.360.340.365'], ['G05.400'], ['E05.820.150.390', 'G05.090.390'], ['E01.370.225.500.620.670.325', '... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
SPARC inhibits adipogenesis by its enhancement of beta-catenin signaling. | SPARC (secreted protein acidic and rich in cysteine) modulates interactions between cells and extracellular matrix and is enriched in white adipose tissue. We have reported that SPARC-null mice accumulate significantly more fat than wild-type mice and maintain relatively high levels of serum leptin. We now show that SP... | ['Active Transport, Cell Nucleus', 'Adipogenesis', 'Animals', 'Cells, Cultured', 'Gene Expression Regulation', 'Glycoproteins', 'Integrins', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Mice, Knockout', 'Osteoblasts', 'Osteonectin', 'Signal Transduction', 'beta Catenin'] | 18,990,699 | [['G03.143.310.100', 'G03.143.700.100'], ['G04.152.149'], ['B01.050'], ['A11.251'], ['G05.308'], ['D09.400.430', 'D12.776.395'], ['D12.776.543.750.705.408'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420'], ['B01.050.050.136.500.500', 'B01.... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cryopreserved rabbit amniotic membrane alleviated inflammatory response and fibrosis following experimental strabismus surgery in rabbits. | We evaluate the ability of cryopreserved rabbit amniotic membrane (AM) transplantation to reduce postoperative inflammation and the extent of fibrosis following experimental strabismus surgery. Ten white rabbits underwent bilateral superior rectus (SR) muscle resection. In the left eye, the resected SR muscle was wrapp... | ['Amnion', 'Animals', 'Cryopreservation', 'Cytokines', 'Fibrosis', 'Inflammation', 'Inflammation Mediators', 'Rabbits', 'Strabismus'] | 29,065,159 | [['A10.615.284.277', 'A16.254.750.277'], ['B01.050'], ['E01.370.225.500.620.760.160', 'E01.370.225.750.600.760.160', 'E02.792.156', 'E05.200.500.620.760.160', 'E05.200.750.600.760.160', 'E05.760.156'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['C23.550.355'], ['C23.550.470'], ['D23.469'], ['B01.050.150.90... | ['Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Frequent baked egg ingestion was not associated with change in rate of decline in egg skin prick test in children with challenge confirmed egg allergy. | BACKGROUND: It is controversial whether egg-allergic children should strictly avoid all forms of egg, or if regular ingestion of baked egg will either delay or hasten the resolution of egg allergy.OBJECTIVE: This is the first study to examine the relationship between frequency of baked egg ingestion and rate of decline... | ['Child', 'Child, Preschool', 'Cooking', 'Diet', 'Egg Hypersensitivity', 'Eggs', 'Female', 'Humans', 'Immune Tolerance', 'Male', 'Skin Tests', 'Surveys and Questionnaires'] | 23,181,794 | [['M01.060.406'], ['M01.060.406.448'], ['J01.576.423.200.200'], ['G07.203.650.240'], ['C20.543.480.370.150'], ['G07.203.300.470', 'J02.500.470'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G12.535.425'], ['E01.370.225.812.871', 'E05.200.812.871', 'E05.478.594.890'], ['E05.318.308.980', 'N05.715.360.300.800', 'N... | ['Named Groups [M]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Use of body mass index of adults in assessing individual and community nutritional status. | Adult malnutrition is much more widespread than is commonly recognized. Described in this article is the use of body mass index (BMI = weight in kg/(height in metres)2) as a measure of adult nutritional status, both of individuals and of communities. Concurrent assessment of the nutritional status of children and adult... | ['Adult', 'Body Mass Index', 'Child, Preschool', 'Female', 'Humans', 'Male', 'Nutrition Assessment', 'Nutrition Surveys', 'Nutritional Status', 'Obesity', 'Public Health', 'Reproducibility of Results', 'Thinness'] | 8,846,494 | [['M01.060.116'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.585', 'N05.715.360.300.560', 'N06.850.505.557', 'N06.850.520.308.585'], ['E05.318.308.980.485', 'N05.715.360.300.800.469', '... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Inhibition by halothane of release of norepinephrine, but not of dopamine-beta-hydroxylase, from guinea-pig vas deferens. | Halothane strikingly decreases spontaneous and electrically stimulated release of norepinephrine from the isolated guinea pig hypogastric nerve--vas deferens preparation. This depression of adrenergic discharge appears to be a direct action on the sympathetic nerve endings and may in part account for the cardiovascular... | ['Animals', 'Depression, Chemical', 'Dopamine beta-Hydroxylase', 'Electric Stimulation', 'Guinea Pigs', 'Halothane', 'Hypogastric Plexus', 'In Vitro Techniques', 'Male', 'Norepinephrine', 'Vas Deferens'] | 1,149,793 | [['B01.050'], ['G07.690.773.750'], ['D08.811.682.690.708.292'], ['E05.723.402'], ['B01.050.150.900.649.313.992.550'], ['D02.455.526.340'], ['A08.800.050.050.400', 'A08.800.800.060.400'], ['E05.481'], ['D02.033.100.291.502', 'D02.092.063.480', 'D02.092.211.215.746', 'D02.092.311.830', 'D02.455.426.559.389.657.166.175.83... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Association between lipoprotein(a) level and type 2 diabetes: no evidence for a causal role of lipoprotein(a) and insulin. | AIMS: Inverse relationships have been described between the largely genetically determined levels of serum/plasma lipoprotein(a) [Lp(a)], type 2 diabetes (T2D) and fasting insulin. Here, we aimed to evaluate the nature of these relationships with respect to causality.METHODS: We tested whether we could replicate the re... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Apolipoproteins A', 'Case-Control Studies', 'Cohort Studies', 'Cross-Sectional Studies', 'Diabetes Mellitus, Type 2', 'Fasting', 'Female', 'Humans', 'Insulin', 'Lipoprotein(a)', 'Male', 'Mendelian Randomization Analysis', 'Middle Aged', 'Polymorphism, Single Nucleot... | 28,866,807 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D10.532.091.200', 'D12.776.070.400.200', 'D12.776.521.120.200'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E05.318.372.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Peripheral nerve connections influence the appearance of neurosecretary material in neural sheath of ventral ganglion of the fly Sarcophaga bullata: an immunocytochemical study. | This study examined the role of the brain and peripheral connections with the target organs in the appearance of neurosecretary material within the dorsal neural sheath of the ventral ganglion of the fly S. bullata. Specifically, the accumulation of the neuropeptide FMRFamide (the neurosecretary material) was examined ... | ['Animals', 'Diptera', 'FMRFamide', 'Ganglia', 'Immunohistochemistry', 'Microscopy, Fluorescence', 'Myelin Sheath', 'Organ Culture Techniques', 'Peripheral Nervous System'] | 12,622,175 | [['B01.050'], ['B01.050.500.131.617.720.500.500.750'], ['D12.644.400.235', 'D12.776.631.650.235'], ['A08.340'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512', 'H01.158.201.344.512', 'H01.158.201.486.512', 'H01.181.122.573.51... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Endogenous expression of Neuregulin-1 (Nrg1) as a potential modulator of prolactin (PRL) secretion in GH3 cells. | The binding of Neuregulin-1 (Nrg1) to the epidermal growth factor family of receptor tyrosine kinases (ErbB) mediates intercellular and intracellular communication and regulates a broad spectrum of biological processes, such as tumorigenesis and myelination. Recombinant Nrg1 has been shown to control prolactin (PRL) se... | ['Animals', 'Cell Line, Tumor', 'Cells, Cultured', 'Down-Regulation', 'Epidermal Growth Factor', 'Fluorescent Antibody Technique', 'Humans', 'Neuregulin-1', 'Pituitary Gland', 'Prolactin', 'Prolactinoma', 'Protein Isoforms', 'RNA, Small Interfering', 'Rats', 'Receptor, ErbB-2', 'Reverse Transcriptase Polymerase Chain R... | 21,437,657 | [['B01.050'], ['A11.251.210.190', 'A11.251.860.180'], ['A11.251'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['D06.472.317.350', 'D12.644.276.382.500', 'D12.776.467.382.500', 'D23.529.382.500'], ['E01.370.225.500.607.512.240', 'E01.370.225.750.551.512.240', 'E05.200.500.607.512.240', 'E05.200.750.551.512.240',... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Levels of IL-8 and TNF-á decrease in Parkinson's disease. | BACKGROUND: Peripheral immune system abnormalities are associated with Parkinson's disease, but role of inflammatory factors in Parkinson's disease has not been consistently proven yet. Thus, population-based studies are needed in the addition of peripheral dysfunction knowledge associated with Parkinson's disease. IL-... | ['Adult', 'Age Factors', 'Aged', 'Case-Control Studies', 'Enzyme-Linked Immunosorbent Assay', 'Female', 'Humans', 'India', 'Interleukin-8', 'Male', 'Middle Aged', 'Parkinson Disease', 'Sex Factors', 'Statistics, Nonparametric', 'Tumor Necrosis Factor-alpha'] | 27,078,697 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['B01.050.150.900.649.313.988.400.112.400.400... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
In vitro and in vivo anti-malignant melanoma activity of Alocasia cucullata via modulation of the phosphatase and tensin homolog/phosphoinositide 3-kinase/AKT pathway. | Alocasia cucullata, a Chinese herb, has been used as an anticancer treatment in southern China. Phosphatase and tensin (PTEN), is a tumor suppressor gene and the loss of PTEN expression may activate the phosphoinositide-3-kinase (PI3K)/AKT signaling pathway which play a key role in tumors formation and progression. In ... | ['Alocasia', 'Animals', 'Cell Line, Tumor', 'Cell Movement', 'Cell Proliferation', 'Dose-Response Relationship, Drug', 'Down-Regulation', 'Drugs, Chinese Herbal', 'Humans', 'Melanoma', 'Mice', 'Neoplasm Invasiveness', 'PTEN Phosphohydrolase', 'Phosphatidylinositol 3-Kinases', 'Phosphorylation', 'Phytotherapy', 'Plant R... | 29,180,042 | [['B01.650.940.800.575.912.250.618.050.750.066'], ['B01.050'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.198', 'G07.568.500.180'], ['G04.161.750', 'G07.345.249.410.750'], ['G07.690.773.875', 'G07.690.936.500'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['D20.215.784.500.350', 'D26.335'], ['B01.050.150.900.... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The yeast Ku heterodimer is essential for protection of the telomere against nucleolytic and recombinational activities. | The Ku heterodimer, conserved in a wide range of eukaryotes, plays a multiplicity of roles in yeast. First, binding of Ku, which is composed of a 70 kDa (Hdf1p) and an 80 kDa (Hdf2p) subunit [1-3], to double-strand breaks promotes non-homologous end-to-end joining of DNA [3]. Second, Ku appears to participate in DNA re... | ['Antigens, Nuclear', 'Base Sequence', 'Chromosomes, Fungal', 'Crosses, Genetic', 'Cyclin B', 'DNA Helicases', 'DNA Replication', 'DNA-Binding Proteins', 'Dimerization', 'Fungal Proteins', 'Heterozygote', 'Ku Autoantigen', 'Macromolecular Substances', 'Mutagenesis, Site-Directed', 'Nuclear Proteins', 'Oligodeoxyribonuc... | 9,663,392 | [['D12.776.660.625', 'D23.050.290'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A11.284.187.360', 'A19.311', 'G05.360.162.360'], ['E05.393.281'], ['D12.644.360.262.120', 'D12.776.167.218.120', 'D12.776.476.262.120'], ['D08.811.277.040.025.159', 'D08.811.399.340'], ['G02.111.225', 'G05.226'], ['D12.776... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Randomised controlled trial of referral to a telephone-based weight management and healthy lifestyle programme for patients with knee osteoarthritis who are overweight or obese: a study protocol. | INTRODUCTION: Knee osteoarthritis (OA) is one of the most common chronic diseases worldwide and is associated with significant pain and disability. Clinical practice guidelines consistently recommend weight management as a core aspect of care for overweight and obese patients with knee OA; however, provision of such ca... | ['Adult', 'Female', 'Humans', 'Life Style', 'Male', 'Middle Aged', 'New South Wales', 'Obesity', 'Osteoarthritis, Knee', 'Program Evaluation', 'Referral and Consultation', 'Risk Reduction Behavior', 'Telephone', 'Treatment Outcome', 'Weight Reduction Programs'] | 26,940,110 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.458'], ['M01.060.116.630'], ['Z01.639.100.750', 'Z01.678.100.373.750'], ['C18.654.726.500', 'C23.888.144.699.500', 'E01.370.600.115.100.160.120.699.500', 'G07.100.100.160.120.699.500'], ['C05.550.114.606.500', 'C05.799.613.500'], ['E05.337.820... | ['Named Groups [M]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Information Science [L]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
Captopril uncovers kinin-dependent release of arachidonic acid metabolites in carrageenin-induced rat pleurisy. | As previously reported, pretreatment with captopril significantly enhanced pleural exudation of rat carrageenin-induced pleurisy. However, in high molecular weight kininogen-deficient rats (B/N-Katholiek), the pleural exudate volume was significantly less than that of the normal strain (B/N-Kitasato), and captopril pre... | ['Animals', 'Arachidonic Acids', 'Captopril', 'Carrageenan', 'Indomethacin', 'Kininogens', 'Kinins', 'Pleurisy', 'Radioimmunoassay', 'Rats', 'Rats, Inbred Strains', 'Trypsin Inhibitor, Kunitz Soybean'] | 2,681,902 | [['B01.050'], ['D10.251.355.255.100', 'D10.251.355.310.166'], ['D12.125.072.401.623.270'], ['D09.698.152'], ['D03.633.100.473.420'], ['D12.644.276.812.654', 'D12.776.124.125.635', 'D12.776.467.812.654', 'D12.776.811.420', 'D23.119.630', 'D23.469.050.375.425', 'D23.529.812.654'], ['D12.644.276.812', 'D12.776.467.812', '... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Prognostic indices of pathological tooth wear development. | OBJECTIVE: The aim: To study possibilities of prognosis of pathological wear of tooth hard tissues development depending on the functional activity of masticatory muscles.PATIENTS AND METHODS: Materials and methods: In order to achieve the goal of the study, a survey of patients at the age of 19 to 69 years was conduct... | ['Adolescent', 'Adult', 'Electromyography', 'Humans', 'Masticatory Muscles', 'Middle Aged', 'Prognosis', 'Tooth Wear', 'Young Adult'] | 32,759,417 | [['M01.060.057'], ['M01.060.116'], ['E01.370.405.255', 'E01.370.530.255'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.633.567.600', 'A14.530'], ['M01.060.116.630'], ['E01.789'], ['C07.793.818'], ['M01.060.116.815']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The influence of lymph node metastasis in the treatment of squamous cell carcinoma of the oral cavity, oropharynx, larynx, and hypopharynx: N0 versus N+. | OBJECTIVES/HYPOTHESIS: Management of the N0 neck is a continuing controversy. The study compares the influence of N0 and N+ disease on the results of treating squamous cell carcinoma (SCCA) of the oral cavity (OC), oropharynx (OP), larynx (LX), and hypopharynx (HP) with five different treatment modalities. The study al... | ['Age Factors', 'Aged', 'Carcinoma, Squamous Cell', 'Cause of Death', 'Disease-Free Survival', 'Female', 'Follow-Up Studies', 'Humans', 'Hypopharyngeal Neoplasms', 'Laryngeal Neoplasms', 'Lymph Node Excision', 'Lymphatic Metastasis', 'Male', 'Middle Aged', 'Mouth Neoplasms', 'Neoadjuvant Therapy', 'Neoplasm Recurrence,... | 15,805,872 | [['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['E05.318.308.985.550.250', 'N01.224.935.698.100', 'N06.850.505.400.975.550.250', 'N06.850.520.308.985.550.250'], ['E01.789.800.190', 'E05.318.740.998.300', 'N04.761.559.590.800.190', 'N05.715.360.575.575.800.1... | ['Health Care [N]', 'Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The isolation of Pseudomonas and other Gram(-) psychrotrophic bacteria in raw milks. | In this research, totally 200 raw milk samples in different areas of Ankara were collected from various dairy plant. The isolated psychotrophic bacteria from the raw milk samples are the species of Pseudomonas spp., Acinetobacter spp., Alcaligenes and Aeromonas. Isolation of Pseudomonas and other gram(-) psychrotrophic... | ['Animals', 'Food Microbiology', 'Gram-Negative Bacteria', 'Milk', 'Pseudomonas', 'Seasons'] | 9,637,013 | [['B01.050'], ['H01.158.273.540.274.332', 'J01.576.423.850.730.500.249.300', 'N06.850.425.200', 'N06.850.460.400.300', 'N06.850.601.500.249.300'], ['B03.440'], ['A12.200.455', 'A12.790', 'G07.203.100.700', 'G07.203.300.350.525', 'J02.200.700', 'J02.500.350.525'], ['B03.440.400.425.625.625', 'B03.660.250.580.590'], ['G0... | ['Organisms [B]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 |
IL-9 aggravates the development of atherosclerosis in ApoE-/- mice. | AIMS: Recently, interleukin (IL)-9 was found to be involved in the pathogenesis of many inflammatory diseases. Here, we tested whether IL-9 was related to atherosclerosis and investigated the underlying mechanisms.METHODS AND RESULTS: IL-9R was expressed in mouse aortic endothelial cells (MAECs) and aortic tissues, and... | ['Acute Coronary Syndrome', 'Animals', 'Antibodies, Monoclonal', 'Aorta, Thoracic', 'Aortic Diseases', 'Apolipoproteins E', 'Atherosclerosis', 'CD4-Positive T-Lymphocytes', 'Cells, Cultured', 'Coculture Techniques', 'Disease Models, Animal', 'Disease Progression', 'Endothelial Cells', 'Humans', 'Interleukin-9', 'Male',... | 25,784,693 | [['C14.280.647.124', 'C14.907.585.124'], ['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['A07.015.114.056.372'], ['C14.907.109'], ['D10.532.091.500', 'D12.776.070.400.500', 'D12.776.521.120.500'], ['C14.907.137.126.307'], ['A11.118.637.555.567.569.200', 'A15.... | ['Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Determination of the average shape of flagellar bends: a gradient curvature model. | Data obtained by manual digitization of photographs of flagellar bending waves have been analyzed by determining size parameters for the bends by least-squares fitting of a model waveform. These parameters were then used to normalize the data so that the average shape of the bends could be determined. Best fits were ob... | ['Animals', 'Flagella', 'Male', 'Mathematics', 'Models, Biological', 'Sea Urchins', 'Sperm Tail', 'Spermatozoa'] | 3,390,867 | [['B01.050'], ['A11.284.180.290'], ['H01.548'], ['E05.599.395'], ['B01.050.500.408.578'], ['A05.360.490.890.840', 'A11.284.180.290.835', 'A11.497.760.500'], ['A05.360.490.890', 'A11.497.760']] | ['Organisms [B]', 'Anatomy [A]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of Ro15-4513 and other benzodiazepine receptor inverse agonists on alcohol-induced intoxication in the rat. | The ability of the imidazobenzodiazepine Ro15-4513 to antagonize the behavioral intoxication produced by ethanol and related short-chain alcohols was examined in the rat. Ro15-4513 dose dependently (0.5-10 mg/kg i.p.: IC50, 1.5 mg/kg) inhibited the intoxication induced by ethanol (2 g/kg), as well as t-amyl alcohol (0.... | ['Alcoholic Intoxication', 'Animals', 'Azides', 'Benzodiazepines', 'Carbolines', 'Chlorides', 'Ethanol', 'Ion Channels', 'Male', 'Pyrazoles', 'Rats', 'Rats, Inbred Strains', 'Receptors, GABA-A'] | 2,455,039 | [['C25.775.100.175', 'F03.900.100.300'], ['B01.050'], ['D01.625.100', 'D02.159'], ['D03.633.100.079.080'], ['D03.383.725.150', 'D03.633.100.473.155', 'D03.633.300.154'], ['D01.210.450.150', 'D01.248.497.158.215'], ['D02.033.375'], ['D12.776.157.530.400', 'D12.776.543.550.450', 'D12.776.543.585.400'], ['D03.383.129.539'... | ['Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Spinocerebellar ataxia type 1 (SCA1): new pathoanatomical and clinico-pathological insights. | AIMS: Spinocerebellar ataxia type 1 (SCA1) represents the first molecular genetically characterized autosomal dominantly inherited cerebellar ataxia and is assigned to the CAG-repeat or polyglutamine diseases. Owing to limited knowledge about SCA1 neuropathology, appropriate pathoanatomical correlates of a large variet... | ['Adult', 'Aged', 'Brain', 'Female', 'Humans', 'Male', 'Middle Aged', 'Nerve Degeneration', 'Nerve Tissue Proteins', 'Peptides', 'Spinocerebellar Ataxias'] | 22,309,224 | [['M01.060.116'], ['M01.060.116.100'], ['A08.186.211'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C23.550.737'], ['D12.776.631'], ['D12.644'], ['C10.228.140.252.190.530', 'C10.228.140.252.700.700', 'C10.228.854.787.875', 'C10.574.500.825.700', 'C10.597.350.090.500.530', 'C16.320.400.780.87... | ['Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Functional coupling of creatine kinases in muscles: species and tissue specificity. | Creatine kinase (CK) isoenzymes are present in all vertebrates. An important property of the creatine kinase system is that its total activity, its isoform distribution, and the concentration of guanidino substrates are highly variable among species and tissues. In the highly organized structure of adult muscles, it ha... | ['Adenine Nucleotides', 'Animals', 'Body Weight', 'Calcium', 'Creatine', 'Creatine Kinase', 'Energy Metabolism', 'Isoenzymes', 'Mitochondria', 'Muscle Contraction', 'Muscles', 'Myocardium', 'Organ Size', 'Vertebrates'] | 9,746,324 | [['D03.633.100.759.646.138', 'D13.695.667.138', 'D13.695.827.068'], ['B01.050'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D02.078.370.280', 'D12.125.373'], ['D08.811.913.696.640.150'], ['... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Evaluation of the efficiency of the shaping of brehmstrahlung beams on electron accelerators]. | Proceeding from analysis of the influence of parameters of the target-filter system on radiation-physical characteristics of braking radiation, some recommendations were issued for assessment of the efficacy of the forming systems of medical accelerators of electrons. A new criterion--a coefficient of the forming syste... | ['Absorption', 'Efficiency', 'Electrons', 'Equipment Design', 'Mathematics', 'Models, Structural', 'Particle Accelerators', 'Radiotherapy Dosage'] | 3,419,304 | [['G01.015', 'G02.010', 'G03.015', 'G03.787.024', 'G07.690.725.015'], ['F02.784.692.351', 'N04.452.209'], ['G01.249.335', 'G01.358.500.750'], ['E05.320'], ['H01.548'], ['J01.897.280.500.545', 'L01.178.820.090.545'], ['E07.710.680'], ['E02.815.639']] | ['Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]'] | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 |
Feline immunodeficiency virus envelope glycoprotein mediates apoptosis in activated PBMC by a mechanism dependent on gp41 function. | Feline Immunodeficiency Virus (FIV) is a lentivirus that causes immunodeficiency in cats, which parallels HIV-1-induced immunodeficiency in humans. It has been established that HIV envelope (Env) glycoprotein mediates T cell loss via a mechanism that requires CXCR4 binding. The Env glycoprotein of FIV, similar to HIV, ... | ['Animals', 'Anti-HIV Agents', 'Apoptosis', 'Cats', 'Cell Fusion', 'Cell Survival', 'Cells, Cultured', 'Glycoproteins', 'Heterocyclic Compounds', 'Immunodeficiency Virus, Feline', 'Leukocytes, Mononuclear', 'Membrane Fusion', 'Mutation', 'Receptors, CXCR4', 'Receptors, OX40', 'Receptors, Tumor Necrosis Factor', 'Viral ... | 15,567,436 | [['B01.050'], ['D27.505.954.122.388.077.088'], ['G04.146.954.035'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['E05.242.307', 'G04.155'], ['G04.346'], ['A11.251'], ['D09.400.430', 'D12.776.395'], ['D03'], ['B04.820.650.589.530.400'], ['A11.118.637.555', 'A15.145.229.637.555', 'A15.382.490.555'], ['G04.575'], ['G... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Pharmacokinetics of ketanserin in patients with cirrhosis. | The pharmacokinetics of ketanserin, a new serotonin S2 (5HT2) antagonist, were studied in 26 patients with cirrhosis. Patients were randomised to receive either a single oral dose of ketanserin 20mg (n = 14) or 40mg (n = 8) or an intravenous dose of ketanserin 5mg (n = 4). The plasma kinetics of ketanserin and its meta... | ['Administration, Oral', 'Chromatography, High Pressure Liquid', 'Female', 'Humans', 'Injections, Intravenous', 'Ketanserin', 'Liver Cirrhosis', 'Male', 'Middle Aged', 'Models, Biological'] | 2,379,381 | [['E02.319.267.100'], ['E05.196.181.400.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.267.082.750', 'E02.319.267.530.540'], ['D03.383.621.365', 'D03.633.100.786.830.333'], ['C06.552.630', 'C23.550.355.412'], ['M01.060.116.630'], ['E05.599.395']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Solution structure of a peptide nucleic acid duplex from NMR data: features and limitations. | This paper describes the results of a 1D and 2D NMR spectroscopy study of a palindromic 8-base pair PNA duplex GGCATGCC in H2O and H2O-D2O solutions. The (1)H NMR peaks have been assigned for most of the protons of the six central base pairs, as well as for several amide protons of the backbone. The resulting 36 interb... | ['Computer Simulation', 'Models, Molecular', 'Nuclear Magnetic Resonance, Biomolecular', 'Peptide Nucleic Acids', 'Protein Structure, Tertiary'] | 18,781,753 | [['L01.224.160'], ['E05.599.595'], ['E05.196.867.519.550'], ['D13.695.578.424.550'], ['G02.111.570.820.709.610']] | ['Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
[In-progress matrix for occupational cancer recognition]. | BACKGROUND: In Italy only a small proportion of all cancers is reported to the national labour insurance board and recognized as having an occupational origin. Cancers with a lower etiological fraction such as lung or bladder cancer have a lower rate of recognition than mesotheliomas or sino-nasal tumours either becaus... | ['Bibliometrics', 'Humans', 'Neoplasms', 'Occupational Diseases', 'Population Surveillance'] | 18,254,538 | [['L01.178.682.099.325', 'L01.453.183.291'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04'], ['C24'], ['E05.318.308.980.438.700', 'N05.715.360.300.800.438.625', 'N06.850.520.308.980.438.700', 'N06.850.780.675']] | ['Information Science [L]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Blocking endocytosis in Drosophila's circadian pacemaker neurons interferes with the endogenous clock in a PDF-dependent way. | The neuropeptide pigment-dispersing factor (PDF) plays an essential role in the circadian clock of the fruit fly Drosophila melanogaster, but many details of PDF signaling in the clock network are still unknown. We tried to interfere with PDF signaling by blocking the GTPase Shibire in PDF neurons. Shibire is an orthol... | ['Animals', 'Animals, Genetically Modified', 'Brain', 'Circadian Rhythm', 'Drosophila Proteins', 'Drosophila melanogaster', 'Dynamins', 'Endocytosis', 'Female', 'Genes, Insect', 'Male', 'Motor Activity', 'Mutation', 'Neurons', 'Neuropeptides', 'Photoperiod', 'Receptors, G-Protein-Coupled', 'Signal Transduction'] | 19,916,833 | [['B01.050'], ['B01.050.050.136', 'B05.620.136'], ['A08.186.211'], ['G07.180.562.190'], ['D12.776.093.500.462'], ['B01.050.500.131.617.720.500.500.750.310.250.500'], ['D08.811.277.040.330.200', 'D12.776.220.600.450.200', 'D12.776.543.990.400'], ['G04.417'], ['G05.360.340.024.340.340', 'G05.360.340.357.500'], ['F01.145.... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Repeated gamma irradiation attenuates collagen-induced arthritis via up-regulation of regulatory T cells but not by damaging lymphocytes directly. | We recently reported that repeated 0.5-Gy gamma irradiation attenuates the pathology of collagen-induced arthritis. In this study, to investigate the mechanism further, we focused on changes in Treg/Th17 cells and changes in the production of antibody against an external antigen in response to gamma irradiation as well... | ['Animals', 'Arthritis, Experimental', 'Collagen', 'Gamma Rays', 'Male', 'Mice', 'Mice, Inbred BALB C', 'Mice, Inbred DBA', 'T-Lymphocytes, Regulatory', 'Up-Regulation'] | 20,726,718 | [['B01.050'], ['C05.550.114.015', 'E05.598.500.249'], ['D05.750.078.280', 'D12.776.860.300.250'], ['G01.358.500.505.300', 'G01.750.250.300', 'G01.750.750.400'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.338', 'B01.050.150.900.649.313.992.635.505.500.400.338'], ['B01.050.050.199.520.520.500'... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Release of Per- and Polyfluoroalkyl Substances (PFASs) from Carpet and Clothing in Model Anaerobic Landfill Reactors. | Discarded carpet and clothing are potential sources of per- and polyfluoroalkyl substances (PFASs) in landfill leachate, but little is known about their release when disposed in landfills. The concentrations of 70 PFASs in the aqueous phase of anaerobic model landfill reactors filled with carpet or clothing were monito... | ['Clothing', 'Floors and Floorcoverings', 'Models, Theoretical', 'Waste Disposal Facilities', 'Water Pollutants, Chemical'] | 27,095,439 | [['J01.637.215'], ['J01.086.339.140'], ['E05.599'], ['N06.850.780.200.800.800.900.449', 'N06.850.860.510.900.700'], ['D27.888.284.903.655']] | ['Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Analysis of a national toll free suicide crisis line in South Africa. | The first national toll free suicide crisis line for South Africa was launched in October 2003 with the aim of providing a service dedicated to the prevention of suicide in this country. The intervention was motivated by South Africa's suicide rate which had risen higher than the global suicide rate, with the majority ... | ['Adolescent', 'Adult', 'Aged', 'Child', 'Crisis Intervention', 'Cross-Sectional Studies', 'Female', 'Hotlines', 'Humans', 'Male', 'Middle Aged', 'Registries', 'South Africa', 'Suicide', 'Surveys and Questionnaires'] | 17,397,281 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.406'], ['F04.754.252'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['N02.421.297.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.308.970', 'N04.452.859.819', 'N05.715.360.300.715.... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Mobile-bearing, congruent patellofemoral prosthesis: short-term results. | PURPOSE: To report the short-term outcome of the low contact stress (LCS) patellofemoral prosthesis in 51 knees.METHODS: 12 men and 37 women aged 23 to 79 (mean, 53.4) years underwent 51 consecutive LCS patellofemoral replacements. All patients had symptomatic isolated arthritis in the patellofemoral joint with well-pr... | ['Adult', 'Aged', 'Arthritis', 'Arthroplasty, Replacement, Knee', 'Disease Progression', 'Female', 'Humans', 'Joint Prosthesis', 'Kaplan-Meier Estimate', 'Male', 'Middle Aged', 'Patellofemoral Joint', 'Prosthesis Design', 'Reoperation', 'Treatment Outcome', 'Young Adult'] | 23,255,644 | [['M01.060.116'], ['M01.060.116.100'], ['C05.550.114'], ['E04.555.110.110.115', 'E04.650.110.115', 'E04.680.101.110.115'], ['C23.550.291.656'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E07.695.400'], ['E05.318.740.998.650', 'N05.715.360.750.795.650', 'N06.850.520.830.998.650'], ['M01.060.116.630'], ['A02.835.... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A predictive model of hopefulness for adolescents. | PURPOSE: To develop a predictive model of hopefulness using the variables of age, gender, and self-esteem among a sample of adolescents with cancer and a sample of healthy adolescents.METHODS: Forty-five healthy adolescents were individually matched with 45 adolescents with cancer on the basis of gender and age. Of the... | ['Adaptation, Psychological', 'Adolescent', 'Adolescent Behavior', 'Attitude to Health', 'Case-Control Studies', 'Female', 'Humans', 'Life Change Events', 'Male', 'Models, Psychological', 'Neoplasms', 'Predictive Value of Tests', 'Psychology, Adolescent', 'Self Concept', 'Sex Distribution', 'Sex Factors', 'Social Adjus... | 15,581,527 | [['F01.058'], ['M01.060.057'], ['F01.145.022'], ['F01.100.150', 'N05.300.150'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.458.410'], ['E05.599.695'], ['C04'], ['E05.318.370.800.650', 'N05.715.360.325.700.640', 'N06.850.520.4... | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Bile increases lipopolysaccharide release in experimental E. coli peritonitis. | Previous studies in rats showed increased mortality when bile was added to intraperitoneally injected Escherichia coli. In the present study bacterial counts and levels of lipo-polysaccharide (LPS) were determined in the peritoneal cavity and in blood 0.5, 1, 4 and 10 hours after induction of peritonitis with E. coli a... | ['Animals', 'Bile', 'Chromatography, Gas', 'Endotoxins', 'Escherichia coli', 'Escherichia coli Infections', 'Injections, Intraperitoneal', 'Lipopolysaccharides', 'Male', 'Peritonitis', 'Rats', 'Rats, Inbred Strains'] | 1,676,304 | [['B01.050'], ['A12.200.087'], ['E05.196.181.349'], ['D23.946.123.329'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['C01.150.252.400.310.330'], ['E02.319.267.530.490'], ['D09.400.500', 'D09.698.718.450', 'D10.494', 'D23.050.161.616.525', 'D23.946.123.329.500'], ['C01.463.600', 'C06.844.640'], ['B01.050.15... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effect of average litter weight in pigs on growth performance, carcass characteristics and meat quality of the offspring as depending on birth weight. | Offspring born from normal litter size (10 to 15 piglets) but classified as having lower than average birth weight (average of the sow herd used: 1.46 ± 0.2 kg; mean ± s.d.) carry at birth negative phenotypic traits normally associated with intrauterine growth restriction, such as brain-sparing and impaired myofiber hy... | ['Animals', 'Birth Weight', 'Female', 'Male', 'Meat', 'Sus scrofa', 'Switzerland', 'Weaning'] | 23,896,082 | [['B01.050'], ['C23.888.144.186', 'E01.370.600.115.100.160.120.186', 'E05.041.124.160.750.149', 'G07.100.100.160.120.186', 'G07.345.249.314.120.186'], ['G07.203.300.600', 'J02.500.600'], ['B01.050.150.900.649.313.500.880.399'], ['Z01.542.883'], ['G07.203.650.220.500.750', 'G07.203.650.915']] | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 |
2D ultrasound augmented by virtual tools for guidance of interventional procedures. | Many intracardiac procedures can currently be performed on the heart only after it has been arrested, and the patient has been placed on cardio-pulmonary bypass. We have developed a new method for operating on multiple targets inside the beating heart, and describe a procedure for accessing them under virtual-reality (... | ['Echocardiography', 'Heart Valve Prosthesis', 'Humans', 'Image Processing, Computer-Assisted', 'Ontario', 'Surgery, Computer-Assisted', 'Thoracic Surgery'] | 17,377,295 | [['E01.370.350.130.750', 'E01.370.350.850.220', 'E01.370.370.380.220'], ['E07.695.310'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['Z01.107.567.176.639'], ['E04.749'], ['H02.403.810.803']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Information Science [L]', 'Geographicals [Z]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 |
The development of a controlled medical terminology: identification, collaboration, and customization. | An increasing focus in health care is the development and use of electronic medical record systems to capture and store patient information. T-HELPER is an electronic medical record system that health care providers use to record ambulatory-care patient progress notes. These data are stored in an on-line database and a... | ['Ambulatory Care', 'HIV Infections', 'Medical Records Systems, Computerized', 'Terminology as Topic', 'Vocabulary, Controlled'] | 8,591,141 | [['E02.760.106', 'N02.421.585.106'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['E05.318.308.940.968.625', 'L01.313.500.750.300.695', 'N04.452.859.564.650', 'N05.715.360.300.715.500.530', 'N06.850.520.308.940.968.625'], ['L01.559.598.400'... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Information Science [L]'] | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
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