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Anti-inflammatory effects of benfotiamine are mediated through the regulation of the arachidonic acid pathway in macrophages. | Benfotiamine, a lipid-soluble analogue of vitamin B1, is a potent antioxidant that is used as a food supplement for the treatment of diabetic complications. Our recent study (U.C. Yadav et al., Free Radic. Biol. Med. 48:1423-1434, 2010) indicates a novel role for benfotiamine in the prevention of bacterial endotoxin, l... | ['Animals', 'Anti-Inflammatory Agents', 'Arachidonic Acid', 'Cell Adhesion', 'Cell Death', 'Cell Line', 'Cyclooxygenase 2', 'Dinoprostone', 'Epoprostenol', 'Extracellular Matrix Proteins', 'Extracellular Signal-Regulated MAP Kinases', 'Gene Expression', 'Inflammation', 'Leukotrienes', 'Lipopolysaccharides', 'Macrophage... | 22,067,901 | [['B01.050'], ['D27.505.954.158'], ['D10.251.355.255.100.100', 'D10.251.355.310.166.100'], ['G04.022'], ['G04.146'], ['A11.251.210'], ['D08.811.600.720.750'], ['D10.251.355.255.550.250.200', 'D23.469.050.175.725.250.200'], ['D10.251.355.255.550.550.500', 'D23.469.050.175.725.550.500'], ['D12.776.860.300'], ['D08.811.91... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Synthesis of a novel series of imidazo[4,5-c]pyrazole derivatives and their evaluation as herbicidal agents. | Ever changing problems in agricultural weed control require periodic introduction of new herbicides. Imidazo[4,5-c]pyrazoles, which were considered of interest as potential herbicides, were synthesized and examined for the pre-emergence, post-emergence, and post-transplant control of weeds in rice against broadleaf and... | ['Arabidopsis', 'Herbicides', 'Poaceae', 'Pyrazoles'] | 10,575,365 | [['B01.650.940.800.575.912.250.157.100'], ['D27.720.031.700.366', 'D27.888.723.366'], ['B01.650.940.800.575.912.250.822'], ['D03.383.129.539']] | ['Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Molecular analysis of core kinetochore composition and assembly in Drosophila melanogaster. | BACKGROUND: Kinetochores are large multiprotein complexes indispensable for proper chromosome segregation. Although Drosophila is a classical model organism for studies of chromosome segregation, little is known about the organization of its kinetochores.METHODOLOGY/PRINCIPAL FINDINGS: We employed bioinformatics, prote... | ['Amino Acid Sequence', 'Animals', 'Cells, Cultured', 'Chromatography, Affinity', 'Drosophila Proteins', 'Drosophila melanogaster', 'Electrophoresis, Polyacrylamide Gel', 'Kinetochores', 'Mass Spectrometry', 'Molecular Sequence Data', 'Proteomics', 'Sequence Homology, Amino Acid'] | 17,534,428 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['A11.251'], ['E05.196.181.400.170'], ['D12.776.093.500.462'], ['B01.050.500.131.617.720.500.500.750.310.250.500'], ['E05.196.401.402', 'E05.301.300.319'], ['A11.284.430.106.279.345.190.160.165.500', 'G05.360.160.165.500'], ['E05.196.566'], ['L01.453.245.667'], ... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Distinct cellular loci for the ABCA1-dependent and ABCA1-independent lipid efflux mediated by endogenous apolipoprotein E expression. | OBJECTIVE: Macrophage expression of both apolipoprotein E (apoE) and ABCA1 have been shown to modulate lipid efflux from these cells and to play an important atheroprotective role in vivo. We evaluated the relationship between apoE and ABCA1 for regulating cellular sterol efflux.METHODS AND RESULTS: ApoE-mediated, but ... | ['ATP Binding Cassette Transporter 1', 'ATP-Binding Cassette Transporters', 'Adenoviridae', 'Animals', 'Apolipoprotein A-I', 'Apolipoproteins E', 'Atherosclerosis', 'Biological Transport', 'Cell Line', 'Cholesterol', 'Dermis', 'Fibroblasts', 'Gene Expression', 'Macrophages, Peritoneal', 'Mice', 'Mice, Knockout', 'Phosp... | 16,254,198 | [['D12.776.157.530.100.050.500', 'D12.776.395.550.020.381.500', 'D12.776.543.550.192.381.500', 'D12.776.543.585.100.190.500'], ['D12.776.157.530.100', 'D12.776.395.550.020', 'D12.776.543.550.192', 'D12.776.543.585.100'], ['B04.280.030'], ['B01.050'], ['D10.532.091.200.100', 'D12.776.070.400.200.100', 'D12.776.521.120.2... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Frugivory and seed dispersal patterns of the red-ruffed lemur, Varecia rubra, at a forest restoration site in Masoala National Park, Madagascar. | Frugivorous primates can play a critical role in the regeneration of degraded habitats by dispersing seeds of their food plants. We studied the diet and seed dispersal patterns of 3 groups of habituated red-ruffed lemurs (Varecia rubra) in a rain forest restoration site in Masoala National Park, Madagascar, to assess t... | ['Animal Nutritional Physiological Phenomena', 'Animals', 'Biodiversity', 'Conservation of Natural Resources', 'Diet', 'Digestion', 'Female', 'Forests', 'Fruit', 'Herbivory', 'Lemuridae', 'Madagascar', 'Magnoliopsida', 'Male', 'Seed Dispersal', 'Trees'] | 25,323,399 | [['G07.203.650.161'], ['B01.050'], ['G16.500.275.157.049', 'N06.230.124.049'], ['J01.256', 'N06.230.080'], ['G07.203.650.240'], ['G07.203.650.250', 'G10.261.190'], ['G16.500.275.157.437', 'N06.230.124.343'], ['A18.024.500', 'G07.203.300.562', 'J02.500.562'], ['F01.145.113.547.600', 'F01.145.407.758', 'G07.203.650.353.7... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]'] | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
Leiomyosarcoma of the ovarian vein: an unusual cause of severe abdominal and flank pain. | Leiomyosarcoma arising from the ovarian vein is extremely rare: only one case was found in the literature. We report a case in a sixty-one-year-old woman who had unexplained attacks of pain in her left lower abdomen and flank for two years. | ['Female', 'Humans', 'Leiomyosarcoma', 'Middle Aged', 'Ovarian Neoplasms', 'Ovary', 'Pain', 'Phlebography', 'Tomography, X-Ray Computed', 'Veins'] | 8,776,624 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.450.590.455', 'C04.557.450.795.455'], ['M01.060.116.630'], ['C04.588.322.455', 'C13.351.500.056.630.705', 'C13.351.937.418.685', 'C19.344.410', 'C19.391.630.705'], ['A05.360.319.114.630', 'A05.360.576.497', 'A06.300.312.497'], ['C23.888.592.612', 'F02.830.816.... | ['Organisms [B]', 'Diseases [C]', 'Named Groups [M]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A comparison of MCC and CEN error measures in multi-class prediction. | We show that the Confusion Entropy, a measure of performance in multiclass problems has a strong (monotone) relation with the multiclass generalization of a classical metric, the Matthews Correlation Coefficient. Analytical results are provided for the limit cases of general no-information (n-face dice rolling) of the ... | ['Algorithms', 'Area Under Curve', 'Artificial Intelligence', 'Computational Biology', 'Computers', 'Entropy', 'Genotype', 'Models, Statistical', 'Oligonucleotide Array Sequence Analysis', 'Probability', 'ROC Curve', 'Reproducibility of Results', 'Software', 'Statistics as Topic'] | 22,905,111 | [['G17.035', 'L01.224.050'], ['E05.318.740.200', 'G03.787.101', 'G07.690.725.064', 'N06.850.520.830.200'], ['G17.035.250', 'L01.224.050.375'], ['H01.158.273.180', 'L01.313.124'], ['L01.224.230.260'], ['G01.906.345'], ['G05.380'], ['E05.318.740.500', 'E05.599.835', 'N05.715.360.750.530', 'N06.850.520.830.500'], ['E05.39... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Same critical features are used for identification of familiarized and unfamiliar faces. | Many studies have shown better recognition for faces we have greater experience with, relative to unfamiliar faces. However, it is still not clear if and how the representation of faces changes during the process of familiarization. In a previous study, we discovered a subset of facial features, for which we have high ... | ['Adult', 'Facial Recognition', 'Female', 'Humans', 'Male', 'Photic Stimulation', 'Recognition, Psychology'] | 29,360,472 | [['M01.060.116'], ['F02.463.593.524.250.500', 'F02.463.593.524.500.500', 'F02.463.593.932.622.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.723.729'], ['F02.463.425.540.706']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Can medical schools teach high school students to be scientists? | The preeminence of science in the United States is endangered for multiple reasons, including mediocre achievement in science education by secondary school students. A group of scientists at Oregon Health and Science University has established a class to teach the process of scientific inquiry to local high school stud... | ['Adolescent', 'Curriculum', 'Data Collection', 'Female', 'Humans', 'Male', 'Oregon', 'Parkinson Disease', 'Program Evaluation', 'Schools, Medical', 'Science', 'Students'] | 17,351,126 | [['M01.060.057'], ['I02.158'], ['E05.318.308', 'L01.399.250', 'N05.715.360.300', 'N06.850.520.308'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.107.567.875.560.550', 'Z01.107.567.875.580.550'], ['C10.228.140.079.862.500', 'C10.228.662.600.400', 'C10.574.928.750'], ['E05.337.820', 'N04.761.685', 'N05.715.360... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Diseases [C]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
Patient-specific imaging and missed tumors: a catastrophic outcome. | Patient-specific instrumentation (PSI) is a relatively new technology aimed at increasing the accuracy and efficiency of total knee arthroplasty (TKA). Its premise is reliant upon preoperative imaging techniques to acquire detailed measurements of a patient's distal femur and proximal tibia. Although a limited number o... | ['Aged', 'Aged, 80 and over', 'Arthroplasty, Replacement, Knee', 'Femoral Neoplasms', 'Humans', 'Knee Joint', 'Knee Prosthesis', 'Male', 'Osteosarcoma', 'Radiography', 'Surgery, Computer-Assisted', 'Treatment Outcome'] | 24,471,144 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['E04.555.110.110.115', 'E04.650.110.115', 'E04.680.101.110.115'], ['C04.588.149.276', 'C05.116.231.343'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.583.475'], ['E07.695.400.410'], ['C04.557.450.565.575.650', 'C04.557.450.795.620'], ['E01.370.350.700'], ['... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Yiqi Tongluo Particles improve Qi-deficiency and blood stasis in multiple cerebral infarction rats by promoting angiogenesis]. | This research was aimed to evaluate the protective effect and potential mechanism of Yiqi Tongluo Particles(YQTLs).Firstly,an animal model of multiple cerebral infarction(MCI) with Qi deficiency and blood stasis was established.Rats were randomly divided into six groups:SHAM group,Vehicle group,Buyang Huanwu decoction ... | ['Angiogenesis Inducing Agents', 'Animals', 'Cerebral Infarction', 'Drugs, Chinese Herbal', 'Proteomics', 'Qi', 'Random Allocation', 'Rats'] | 30,868,821 | [['D27.505.696.377.077.077'], ['B01.050'], ['C10.228.140.300.150.477.200', 'C10.228.140.300.775.200.200', 'C14.907.253.092.477.200', 'C14.907.253.855.200.200', 'C23.550.513.355.250.200', 'C23.550.717.489.250.200'], ['D20.215.784.500.350', 'D26.335'], ['H01.158.201.843', 'H01.158.273.180.350.700', 'H01.158.273.343.350.7... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 |
CPPred: coding potential prediction based on the global description of RNA sequence. | The rapid and accurate approach to distinguish between coding RNAs and ncRNAs has been playing a critical role in analyzing thousands of novel transcripts, which have been generated in recent years by next-generation sequencing technology. Previously developed methods CPAT, CPC2 and PLEK can distinguish coding RNAs and... | ['Algorithms', 'Animals', 'Base Sequence', 'Computational Biology', 'Datasets as Topic', 'Drosophila melanogaster', 'High-Throughput Nucleotide Sequencing', 'Humans', 'Mice', 'RNA, Messenger', 'RNA, Untranslated', 'Saccharomyces cerevisiae', 'Sequence Analysis, RNA', 'Zebrafish'] | 30,753,596 | [['G17.035', 'L01.224.050'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['H01.158.273.180', 'L01.313.124'], ['E05.318.308.056', 'L01.313.500.750.300.188.400.500', 'L01.399.250.224', 'L01.470.750.750.431', 'N05.715.360.300.224', 'N06.850.520.308.056'], ['B01.050.500.131.617.720.500.500.750.3... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Self-directed arm therapy at home after stroke with a sensor-based virtual reality training system. | BACKGROUND: The effect of rehabilitative training after stroke is dose-dependent. Out-patient rehabilitation training is often limited by transport logistics, financial resources and a lack of motivation/compliance. We studied the feasibility of an unsupervised arm therapy for self-directed rehabilitation therapy in pa... | ['Aged', 'Arm', 'Biomechanical Phenomena', 'Feasibility Studies', 'Female', 'Humans', 'Male', 'Middle Aged', 'Movement Disorders', 'Paresis', 'Recovery of Function', 'Self Care', 'Stroke Rehabilitation', 'Therapy, Computer-Assisted', 'Treatment Outcome', 'User-Computer Interface'] | 27,515,583 | [['M01.060.116.100'], ['A01.378.800.075'], ['G01.154.090', 'G01.374.089'], ['E05.318.372.550', 'E05.337.675', 'N05.715.360.330.550', 'N06.850.520.450.550'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C10.228.662'], ['C10.597.636', 'C23.888.592.643'], ['G16.757'], ['E02.900', 'I03.050.563', ... | ['Named Groups [M]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Disciplines and Occupations [H]', 'Information Science [L]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 |
Multiplexed panel of precisely quantified salivary proteins for biomarker assessment. | An increasingly popular "absolute" quantitative technique involves the SRM or MRM approach with stable isotope-labeled standards (SIS). Using this approach, many proteins in human plasma/serum have been quantified for biomarker assessment and disease stratification. Due to the complexity of plasma and the invasive natu... | ['Adult', 'Biomarkers', 'Female', 'Humans', 'Male', 'Peptides', 'Proteomics', 'Reproducibility of Results', 'Saliva', 'Salivary Proteins and Peptides', 'Young Adult'] | 27,538,354 | [['M01.060.116'], ['D23.101'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644'], ['H01.158.201.843', 'H01.158.273.180.350.700', 'H01.158.273.343.350.700', 'H01.181.122.738'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['A12.200.666'], ['D12.644.848', 'D12.776.850'], ['... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Oral health status and risk of bacteremia following allogeneic hematopoietic cell transplantation. | OBJECTIVES: The aim of this study was to evaluate the impact of oral health status on bacteremia risk in a cohort of patients with acute myeloid leukemia (AML) who underwent chemotherapy followed by myeloablative allogeneic hematopoietic cell transplantation (allo-HCT).STUDY DESIGN: A retrospective study was conducted ... | ['Adult', 'Aged', 'Antineoplastic Agents', 'Bacteremia', 'Boston', 'Female', 'Hematopoietic Stem Cell Transplantation', 'Humans', 'Leukemia, Myeloid, Acute', 'Male', 'Middle Aged', 'Oral Health', 'Retrospective Studies', 'Risk Factors', 'Transplantation Conditioning'] | 28,823,316 | [['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.248'], ['C01.150.252.100', 'C01.757.100', 'C23.550.470.790.500.100'], ['Z01.107.567.875.550.510.210', 'Z01.433.210'], ['E02.095.147.500.500.500', 'E04.936.225.687.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.337.539.275'], ['M01.060.116.630'], ['... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Left ventricular remodeling after late revascularization correlates with baseline viability. | The ideal management of stable patients who present late after acute ST-elevation myocardial infarction (STEMI) is still a matter of conjecture. We hypothesized that the extent of improvement in left ventricular function after successful revascularization in this subset was related to the magnitude of viability in the ... | ['Adult', 'Aged', 'Female', 'Humans', 'Male', 'Middle Aged', 'Myocardial Infarction', 'Myocardial Perfusion Imaging', 'Myocardial Revascularization', 'Patient Selection', 'Predictive Value of Tests', 'Radiopharmaceuticals', 'Recovery of Function', 'Severity of Illness Index', 'Stroke Volume', 'Technetium Tc 99m Sestami... | 25,120,390 | [['M01.060.116'], ['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C14.280.647.500', 'C14.907.585.500', 'C23.550.513.355.750', 'C23.550.717.489.750'], ['E01.370.350.130.875', 'E01.370.350.710.600.500', 'E01.370.370.380.500', 'E01.370.384.730.354.500'], ['E04.100.376.719', 'E0... | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Mild Epicureanism: notes toward the definition of a therapeutic attitude. | Psychotherapists generally feel uncomfortable addressing patients' beliefs, particularly religious beliefs, because of the desire to respect client subjectivity and to avoid the abuse of therapeutic authority. This paper's first contention is that at some junctures, investigation of the client's belief structure can be... | ['Attitude to Death', 'Female', 'Humans', 'Judaism', 'Philosophy', 'Professional-Patient Relations', 'Psychoanalytic Therapy', 'Psychotherapeutic Processes', 'Psychotherapy', 'Religion and Psychology'] | 18,605,130 | [['F01.100.125', 'N05.300.125'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['K01.844.385'], ['K01.752'], ['F01.829.401.650', 'N05.300.660'], ['F04.754.709'], ['F04.754.720'], ['F04.754'], ['F02.880', 'K01.844.664']] | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Organisms [B]', 'Humanities [K]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
South African teachers' responses to teenage pregnancy and teenage mothers in schools. | South African law forbids excluding pregnant teenagers from school and permits young parents to continue with their schooling. However, the existence of progressive policy and law does not by itself ensure that pregnant teenagers and young parents remain in school or experience as little disruption to their studies as ... | ['Adolescent', 'Attitude', 'Faculty', 'Female', 'Focus Groups', 'Humans', 'Intergenerational Relations', 'Policy Making', 'Pregnancy', 'Pregnancy in Adolescence', 'Schools', 'South Africa', 'Student Dropouts', 'Young Adult'] | 20,665,296 | [['M01.060.057'], ['F01.100'], ['M01.526.702.250'], ['E05.318.308.112', 'N05.715.360.300.269', 'N06.850.520.308.112'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.263.370.110', 'F01.829.401.190'], ['N03.706.742'], ['G08.686.784.769'], ['G08.686.784.769.494'], ['I02.783', 'J03.832'], ['Z01.058.290.175.735... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Technology, Industry, and Agriculture [J]', 'Geographicals [Z]... | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
Effect of antibiotics on the properties of poly(methylmethacrylate)-based bone cement. | The goal of this study was to examine the relationship between gentamicin concentration in Palacos R bone cement (in the mass fraction range of 0-9.4%) and various properties of the cement. The results from the thermal, density, and static compression tests show that gentamicin favors the cement polymerization in its f... | ['Anti-Bacterial Agents', 'Biomechanical Phenomena', 'Bone Cements', 'Compressive Strength', 'Gentamicins', 'Humans', 'In Vitro Techniques', 'Materials Testing', 'Microscopy, Electron, Scanning', 'Polymethyl Methacrylate'] | 12,418,027 | [['D27.505.954.122.085'], ['G01.154.090', 'G01.374.089'], ['D05.750.716.822.300', 'D25.720.716.822.300', 'D27.720.102.158', 'J01.637.051.720.716.822.300'], ['G01.374.180'], ['D09.408.051.374'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.481'], ['E05.570'], ['E01.370.350.515.402.541', 'E05.595.402.541'], ['D... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Picosecond rotation of small polar fluorophores in the cytosol of sea urchin eggs. | A new fluorescence method to measure viscosity in cell cytosol [Fushimi, K., & Verkman, A. S. (1991) J. Cell Biol. 112, 719-725] has been applied to determine fluid-phase viscosity in sea urchin eggs. Freshly harvested eggs from Lytechinus pictus were loaded with the dyes 2,7-bis(2-carboxyethyl)-5-(and-6-)carboxyfluore... | ['Animals', 'Cytosol', 'Fluoresceins', 'Fluorescent Dyes', 'Kinetics', 'Microscopy, Fluorescence', 'Ovum', 'Sea Urchins', 'Time Factors', 'Viscosity'] | 1,751,500 | [['B01.050'], ['A11.284.430.214.200', 'A11.284.430.429.200', 'A11.284.835.450.200'], ['D02.455.426.779.347', 'D03.633.300.953.275', 'D04.711.347'], ['D27.720.233.348', 'D27.720.470.410.505.500'], ['G01.374.661', 'G02.111.490'], ['E01.370.350.515.458', 'E05.595.458'], ['A05.360.490.690', 'A11.497.497', 'A16.690'], ['B01... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Degradation of BRCA2 in alkyltransferase-mediated DNA repair and its clinical implications. | Germ-line mutations in BRCA2 have been linked to early-onset familial breast cancer. BRCA2 is known to play a key role in repairing double-strand breaks. Here, we describe the involvement of BRCA2 in O6-alkylguanine DNA alkyltransferase (AGT)-mediated repair of O6-methylguanine adducts. We show that BRCA2 physically as... | ['Alkylating Agents', 'Amino Acid Sequence', 'Animals', 'BRCA2 Protein', 'DNA Repair', 'Gene Deletion', 'Guanine', 'Humans', 'Methylnitronitrosoguanidine', 'Mice', 'Mice, Knockout', 'Mice, Transgenic', 'Molecular Sequence Data', 'O(6)-Methylguanine-DNA Methyltransferase'] | 19,047,179 | [['D27.505.519.124', 'D27.888.569.035'], ['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D12.776.313.249', 'D12.776.624.776.101', 'D12.776.660.105'], ['G02.111.222', 'G05.219'], ['G05.365.590.762.320', 'G05.558.800.320'], ['D03.633.100.759.758.399.454'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Class specificity and the lexical encoding of participant information. | It is commonly assumed across the language sciences that some semantic participant information is lexically encoded and some is not. In this article, we propose that semantic obligatoriness and verb class specificity are criteria which influence whether semantic information is lexically encoded. We present a comprehens... | ['Cognition', 'Humans', 'Linguistics', 'Psycholinguistics', 'Semantics', 'Vocabulary'] | 12,081,394 | [['F02.463.188'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.559.598'], ['F02.694', 'F04.096.586', 'L01.559.598.628'], ['L01.559.598.745'], ['L01.559.598.901']] | ['Psychiatry and Psychology [F]', 'Organisms [B]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
HLA Profile of Celiac Disease among First-Degree Relatives from a Tertiary Care Center in North India. | OBJECTIVE: To study the prevalence of Celiac disease (CD) in first-degree relatives (FDR) of CD children.METHODS: This observational study was performed in FDR (parents and siblings) of consecutive newly diagnosed cases of CD enrolled from January 2011 through March 2012. Screening for CD in FDR was done using IgA tiss... | ['Autoantibodies', 'Celiac Disease', 'Humans', 'Immunoglobulin A', 'India', 'Prevalence', 'Tertiary Care Centers', 'Transglutaminases'] | 27,264,101 | [['D12.776.124.486.485.114.323', 'D12.776.124.790.651.114.323', 'D12.776.377.715.548.114.323'], ['C06.405.469.637.250', 'C18.452.603.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.124.486.485.114.619.026', 'D12.776.124.790.651.114.619.026', 'D12.776.377.715.548.114.619.026'], ['Z01.252.245.393'], ['E... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Influence of CA 15-3 blood level and doubling time on diagnostic performances of 18F-FDG PET in breast cancer patients with occult recurrence. | AIM: To evaluate the influence of CA 15-3 blood level and doubling time on diagnostic performances of 18F-FDG PET in breast cancer patients with occult recurrence.MATERIALS AND METHODS: Thirty-five 18F-FDG PET examinations in 32 patients with CA 15-3 blood level above the normal range, and negative conventional imaging... | ['Adult', 'Aged', 'Aged, 80 and over', 'Biomarkers, Tumor', 'Female', 'Fluorodeoxyglucose F18', 'Humans', 'Image Enhancement', 'Metabolic Clearance Rate', 'Middle Aged', 'Mucin-1', 'Neoplasm Proteins', 'Neoplasm Recurrence, Local', 'Patient Selection', 'Positron-Emission Tomography', 'Radiopharmaceuticals', 'Reproducib... | 17,325,589 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D23.101.140'], ['D09.254.229.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.600.350', 'L01.224.308.380'], ['E01.370.225.843', 'E05.200.843', 'G03.490', 'G07.690.595', 'G07.690.725.513'], ['M01.060.116.630'], ['D12.776.395.550.560',... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Early postoperative serum cystatin C predicts severe acute kidney injury following cardiac surgery: a post-hoc analysis of a randomized controlled trial. | OBJECTIVE: Acute kidney injury (AKI) after cardiac surgery procedures is associated with poor patient outcomes. Cystatin C as a marker for renal failure has been shown to be of prognostic value; however, a wide range of its predictive accuracy has been reported. The aim of the study was to evaluate whether the measurem... | ['Acute Kidney Injury', 'Aged', 'Aged, 80 and over', 'Cardiac Surgical Procedures', 'Cystatin C', 'Early Diagnosis', 'Female', 'Follow-Up Studies', 'Humans', 'Immunoassay', 'Male', 'Middle Aged', 'Postoperative Complications', 'Predictive Value of Tests', 'Prospective Studies', 'Time Factors'] | 24,397,879 | [['C12.777.419.780.050', 'C13.351.968.419.780.050'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E04.100.376', 'E04.928.220'], ['D12.776.215.300'], ['E01.390'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.478.566',... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Ni adsorption and Ni-Al LDH precipitation in a sandy aquifer: an experimental and mechanistic modeling study. | Mining activities and industries have created nickel (Ni) contaminations in many parts of the world. The objective of this study is to increase our understanding of Ni adsorption and Nickel-Aluminium Layered Double Hydroxide (Ni-Al LDH) precipitation to reduce Ni mobility in a sandy soil aquifer. At pH ? 7.2 both adsor... | ['Adsorption', 'Aluminum', 'Chemical Precipitation', 'Environmental Restoration and Remediation', 'Geologic Sediments', 'Hydrogen-Ion Concentration', 'Mining', 'Models, Theoretical', 'Nickel', 'Silicon Dioxide', 'Soil Pollutants'] | 21,186,070 | [['G01.030', 'G02.020'], ['D01.268.557.050', 'D01.552.547.050'], ['E05.196.150', 'G02.159'], ['N06.230.080.600', 'N06.850.460.375'], ['G01.311.330', 'G16.500.320'], ['G02.300'], ['J01.576.655.875.500'], ['E05.599'], ['D01.268.556.607', 'D01.268.956.625', 'D01.552.544.607'], ['D01.578.750', 'D01.650.550.825', 'D01.837.7... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Lubrication regimes in lumbar total disc arthroplasty. | A number of total disc arthroplasty devices have been developed. Some concern has been expressed that wear may be a potential failure mode for these devices, as has been seen with hip arthroplasty. The aim of this paper was to investigate the lubrication regimes that occur in lumbar total disc arthroplasty devices. The... | ['Arthroplasty', 'Computer Simulation', 'Equipment Failure Analysis', 'Friction', 'Humans', 'Intervertebral Disc', 'Intervertebral Disc Displacement', 'Joint Prosthesis', 'Lubrication', 'Lumbar Vertebrae', 'Models, Biological', 'Motion', 'Prosthesis Design'] | 17,937,201 | [['E04.555.110', 'E04.680.101'], ['L01.224.160'], ['E05.325.192'], ['G01.374.618'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.165.308.410', 'A02.835.232.834.432', 'A10.165.382.350.050'], ['C05.116.900.307', 'C23.300.707.952'], ['E07.695.400'], ['E05.830.583'], ['A02.835.232.834.519'], ['E05.599.395'], ['G0... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Evaluation of plan quality and treatment efficiency for single-isocenter/two-lesion lung stereotactic body radiation therapy. | PURPOSE/OBJECTIVES: To evaluate the plan quality and treatment delivery efficiency of single-isocenter/two-lesions volumetric modulated arc therapy (VMAT) lung stereotactic body radiation therapy (SBRT).MATERIALS/METHODS: Eight consecutive patients with two peripherally located early stage nonsmall-cell-lung cancer (NS... | ['Algorithms', 'Carcinoma, Non-Small-Cell Lung', 'Humans', 'Lung Neoplasms', 'Organs at Risk', 'Quality Control', 'Radiometry', 'Radiosurgery', 'Radiotherapy Dosage', 'Radiotherapy Planning, Computer-Assisted', 'Radiotherapy, Intensity-Modulated', 'Retrospective Studies'] | 30,548,205 | [['G17.035', 'L01.224.050'], ['C04.588.894.797.520.109.220.249', 'C08.381.540.140.500', 'C08.785.520.100.220.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['A01.635'], ['J01.897.608'], ['E05.799'], ['E02.815.530', 'E04.525.800.650', 'E05.873.500'], ['E02.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 |
Non-opsonic attachment of Bordetella bronchiseptica mediated by CD11/CD18 and cell surface carbohydrates. | Porcine atrophic rhinitis associated with Bordetella bronchiseptica is characterized by a severe inflammatory response in the mucosa of the nasal turbinates. Initial infiltrates of polymorphonuclear leukocytes (PMN) are followed by accumulations of mononuclear cells. In this report, we have investigated the interaction... | ['Animals', 'Bacterial Adhesion', 'Bordetella bronchiseptica', 'CD11 Antigens', 'CD18 Antigens', 'Carbohydrates', 'Cattle', 'Cell Adhesion Molecules', 'Granulocytes', 'Phagocytosis', 'Swine'] | 7,752,879 | [['B01.050'], ['G06.099.050'], ['B03.440.400.425.115.425.050', 'B03.660.075.090.344.425.050'], ['D12.776.395.550.200.074', 'D12.776.543.550.200.093', 'D23.050.301.350.074'], ['D12.776.395.550.200.275.750', 'D12.776.543.550.200.275.750', 'D12.776.543.750.705.408.200.249', 'D12.776.543.750.705.408.600.100.750', 'D12.776.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A profiling platform for the characterization of transglutaminase 2 (TG2) inhibitors. | Huntington's disease (HD) is associated with increased expression levels and activity of tissue transglutaminase (TG2), an enzyme primarily known for its cross-linking of proteins. To validate TG2 as a therapeutic target for HD in transgenic models and for eventual clinical development, a selective and brain-permeable ... | ['Animals', 'Biological Assay', 'Cell Line', 'Enzyme Inhibitors', 'GTP-Binding Proteins', 'Humans', 'Huntington Disease', 'Mice', 'Molecular Structure', 'Transglutaminases'] | 20,395,409 | [['B01.050'], ['E05.091'], ['A11.251.210'], ['D27.505.519.389'], ['D08.811.277.040.330.300', 'D12.776.157.325'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.228.140.079.545', 'C10.228.140.380.278', 'C10.228.662.262.249.750', 'C10.574.500.497', 'C16.320.400.430', 'F03.615.250.400', 'F03.615.400.390'], ['B01.0... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Microvascular reconstruction of the mandible. | Five microvascular reconstructions of the mandible were performed in the past 2 years. One dorsalis pedis osteocutaneous flap was used to reconstruct the alveolar ridge and four groin osteocutaneous flaps were used for various defects of the mandible. Free microvascular bone grafts were found useful in previously irrad... | ['Adult', 'Bone Transplantation', 'Female', 'Foot', 'Groin', 'Humans', 'Male', 'Mandible', 'Mandibular Injuries', 'Microcirculation', 'Middle Aged', 'Mouth Neoplasms', 'Osteotomy', 'Surgical Flaps', 'Transplantation, Autologous'] | 6,999,926 | [['M01.060.116'], ['E02.095.147.725.052', 'E04.555.130', 'E04.936.580.052'], ['A01.378.610.250'], ['A01.923.047.365'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.232.781.324.502.632', 'A14.521.632'], ['C10.900.300.284.500.500', 'C26.915.300.425.500.500'], ['G09.330.100.645'], ['M01.060.116.630'], ['C04.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Clinical Application of Chromosomal Microarray Analysis in Karyotyping with Uncertain Genomic Rearrangement]. | OBJECTIVES: To apply chromosomal microarray analysis (CMA) in the diagnosis of karyotyping with uncertain genomic rearrangement.METHODS: We retrospectively reviewed 48 samples (34 samples of amniotic fluid, 14 samples of peripheral blood) of karyotype analyses with uncertain genomic rearrangement in patients admitted t... | ['Chromosome Disorders', 'Female', 'Gene Rearrangement', 'Genome, Human', 'Humans', 'Karyotyping', 'Microarray Analysis', 'Pregnancy', 'Prenatal Diagnosis', 'Retrospective Studies'] | 28,616,926 | [['C16.131.260', 'C16.320.180'], ['G05.344'], ['G05.360.340.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.385.315', 'E05.200.500.385.315', 'E05.242.385.315', 'E05.393.285.475'], ['E05.588.570'], ['G08.686.784.769'], ['E01.370.378.630'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', ... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Clinical 1H magnetic resonance spectroscopy of brain metastases at 1.5T and 3T. | PURPOSE: To investigate whether improvements in signal-to-noise ratio (SNR) and spectral resolution are found in spectra from patients with brain metastases obtained at higher magnetic field strengths using standard clinical instrumentation.MATERIAL AND METHODS: Six patients with brain metastases, 13 healthy volunteers... | ['Adult', 'Aspartic Acid', 'Brain Neoplasms', 'Choline', 'Creatine', 'Female', 'Humans', 'Magnetic Resonance Spectroscopy', 'Male', 'Middle Aged', 'Phantoms, Imaging'] | 16,796,315 | [['M01.060.116'], ['D12.125.067.500', 'D12.125.119.170', 'D12.125.427.040'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['D02.033.100.291.211', 'D02.092.063.291.211', 'D02.092.877.883.333', 'D02.675.276.232'], ['D02.078.370.280', 'D12.125.373'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Dietary long chain n-3 polyunsaturated fatty acids prevent impaired social behaviour and normalize brain dopamine levels in food allergic mice. | Allergy is suggested to exacerbate impaired behaviour in children with neurodevelopmental disorders. We have previously shown that food allergy impaired social behaviour in mice. Dietary fatty acid composition may affect both the immune and nervous system. The aim of this study was to assess the effect of n-3 long chai... | ['3,4-Dihydroxyphenylacetic Acid', 'Animals', 'Brain', 'Chymases', 'Diet', 'Disease Models, Animal', 'Docosahexaenoic Acids', 'Dopamine', 'Fatty Acids, Unsaturated', 'Food Hypersensitivity', 'Homovanillic Acid', 'Hydroxyindoleacetic Acid', 'Immunoglobulins', 'Intestinal Mucosa', 'Male', 'Mice, Inbred C3H', 'Serotonin',... | 25,445,491 | [['D02.241.223.601.220'], ['B01.050'], ['A08.186.211'], ['D08.811.277.656.300.760.103', 'D08.811.277.656.959.350.103'], ['G07.203.650.240'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['D10.212.302.380.410.210', 'D10.251.355.337.250', 'D10.627.430.450.375'], ['D02.092.211.215.406', 'D02.092.311.342', 'D02.455.426.5... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Assessment of balsam of Peru patch tests. | To find an ideal test technique for as low a dose of balsam of Peru (Myroxylon Pereirae) as possible, subjects testing positive to balsam of Peru are re-tested with a 25% concentration of balsam of Peru in petrolatum. Applications are with Finn Chambers for 6 different application times, and directly by foils for 96 h ... | ['Adult', 'Allergens', 'Balsams', 'Dermatitis, Allergic Contact', 'Erythema', 'False Positive Reactions', 'Female', 'Humans', 'Laser-Doppler Flowmetry', 'Male', 'Microdialysis', 'Middle Aged', 'Patch Tests', 'Perfusion', 'Pigments, Biological', 'Predictive Value of Tests', 'Sensitivity and Specificity', 'Skin'] | 10,871,095 | [['M01.060.116'], ['D23.050.063'], ['D05.750.078.840.219', 'D20.215.721.500.219'], ['C17.800.174.255.100', 'C17.800.815.255.100', 'C20.543.418.150'], ['C17.800.229', 'C23.888.885.328'], ['E01.354.506'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.370.475', 'E05.830.500'], ['E05.196.353.500'], ['M01.060.1... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Measurement and modeling of ozone and nitrogen oxides produced by laser breakdown in oxygen-nitrogen atmospheres. | The production of ozone nad nitrogen oxides was studied during multiple laser breakdown in oxygen-nitrogen mixtures at atmospheric pressure. About 2000 laser shots at 10(10) W cm-2 were delivered into a sealed reaction chamber. The chamber with a long capillary was designed to measure absorption of O3, NO, and NO2 as a... | ['Flow Injection Analysis', 'Gases', 'Hot Temperature', 'Lasers', 'Nitrogen', 'Nitrogen Oxides', 'Oxygen', 'Ozone', 'Reproducibility of Results', 'Sensitivity and Specificity', 'Spectrum Analysis'] | 14,658,160 | [['E05.196.460'], ['D01.362'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.775.710.380', 'N06.230.300.100.725.232', 'N06.230.300.100.725.710.380'], ['E07.632.490', 'E07.710.520'], ['D01.268.604', 'D01.362.625'], ['D01.362.635', 'D01.625.550', 'D01.650.550.587'], ['D01.268.185.550', 'D01.362.670'], [... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Prognosis of patients over 75 years of age with a ruptured abdominal aortic aneurysm. | Forty-seven patients (34 males and 13 females) over 75 years of age (mean: 79.7 +/- 3.8 SD) suffering from a ruptured abdominal aortic aneurysm were operated on between 1977 and 1986. In 16 patients (34%), the aneurysm had been diagnosed previously. Seventeen patients (36%) had a delay of 6 hours or more in the beginni... | ['Aged', 'Aorta, Abdominal', 'Aortic Aneurysm', 'Female', 'Humans', 'Male', 'Rupture, Spontaneous'] | 2,773,505 | [['M01.060.116.100'], ['A07.015.114.056.205'], ['C14.907.055.239', 'C14.907.109.139'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.300.909']] | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Infection after pediatric heart transplantation: results of a multiinstitutional study. The Pediatric Heart Transplant Study Group. | BACKGROUND: Detailed information regarding the spectrum and predictors of infection after heart transplantation in children is limited because of relatively small numbers of patients at any single institution. We therefore used combined data obtained from the Pediatric Heart Transplant Study Group to gain additional in... | ['Actuarial Analysis', 'Adolescent', 'Age Factors', 'Bacteremia', 'Bacterial Infections', 'Cause of Death', 'Child', 'Child, Preschool', 'Cytomegalovirus Infections', 'Female', 'Forecasting', 'Heart Transplantation', 'Humans', 'Incidence', 'Infant', 'Infant, Newborn', 'Likelihood Functions', 'Lung Diseases', 'Male', 'M... | 9,436,132 | [['E05.318.740.100', 'N05.715.360.750.100', 'N06.850.520.830.100'], ['M01.060.057'], ['N05.715.350.075', 'N06.850.490.250'], ['C01.150.252.100', 'C01.757.100', 'C23.550.470.790.500.100'], ['C01.150.252'], ['E05.318.308.985.550.250', 'N01.224.935.698.100', 'N06.850.505.400.975.550.250', 'N06.850.520.308.985.550.250'], [... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Named Groups [M]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Spectroscopic and computational studies on the interaction of DNA with pregabalin drug. | The interaction of the drug pregabalin (S-3-(aminomethyl)-5-methylhexanoic acid) with CT-DNA was studied by using fluorescence spectroscopy, UV-Vis, CD, molecular docking study and viscometery. The fluorescence and UV absorption spectroscopy indicated that the drug interacted with CT-DNA in a groove binding mode. The b... | ['Animals', 'Cattle', 'Circular Dichroism', 'DNA', 'Electrons', 'Kinetics', 'Molecular Docking Simulation', 'Pregabalin', 'Spectrometry, Fluorescence', 'Spectrophotometry, Ultraviolet', 'Viscosity'] | 25,467,655 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['E05.196.867.151'], ['D13.444.308'], ['G01.249.335', 'G01.358.500.750'], ['G01.374.661', 'G02.111.490'], ['E05.599.595.249', 'L01.224.160.249'], ['D02.241.081.114.500.350.500', 'D12.125.190.350.450'], ['E05.196.712.516.600.676', 'E05.196.867.726'], ['E05.196.712.7... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Polymorphic regions affecting human height also control stature in cattle. | Orthologous positions of 55 genes associated with height in four human populations were located on the bovine genome. Single nucleotide polymorphisms close to eight of these genes were significantly associated with stature in cattle (Bos taurus and Bos indicus). This suggests that these genes may contribute to controll... | ['Animals', 'Biometry', 'Body Height', 'Cattle', 'Genome-Wide Association Study', 'Humans', 'Polymorphism, Genetic', 'Polymorphism, Single Nucleotide'] | 21,212,230 | [['B01.050'], ['E05.318.740.225', 'N06.850.505.200'], ['E01.370.600.115.100.160.100', 'E05.041.124.160.500', 'G07.100.100.160.100', 'G07.345.249.314.100'], ['B01.050.150.900.649.313.500.380.271'], ['E05.318.370.392', 'E05.318.416.249', 'E05.393.385.500', 'E05.393.522.500', 'E05.393.760.640.500', 'N06.850.520.445.392', ... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Store-Operated Ca2+ | Store-operated Ca2+ entry (SOCE) is an important mechanism of extracellular Ca2+ entry into cells. It has been proved that SOCE is involved in many pathologic and physiological processes. Two key participants of SOCE, stromal interaction molecule1 (STIM1) and Orai1, have been identified. But their function in cardiac f... | ['Angiotensin II', 'Animals', 'Calcium', 'Calcium Signaling', 'Fibroblasts', 'Fibrosis', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Myocardium', 'ORAI1 Protein', 'Rats', 'Rats, Sprague-Dawley', 'Stromal Interaction Molecule 1'] | 27,426,917 | [['D06.472.699.094.078', 'D12.644.400.070.078', 'D12.644.456.073.041', 'D12.644.548.058.078', 'D12.776.631.650.070.078', 'D23.469.050.050.050'], ['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['G02.111.820.800.100', 'G03.143.500.100', 'G04.835.800.100'], ['A11.329.228'], ['C23.550.355'], ['B01.050.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Influences of excessive Cu on photosynthesis and growth in ectomycorrhizal Pinus sylvestris seedlings. | Growth and photosynthesis responses were measured for Scots pine (Pinus sylvestris L. cv.) inoculated with ectomycorrhizal fungi (Suillus bovinus) under 6.5 and 25 mg/L Cu treatments to evaluate ectomycorrhizal seedlings' tolerance to heavy metal stress. Results showed that excessive Cu can significantly impair the gro... | ['Chlorophyll', 'Chlorophyll A', 'Copper', 'Mycorrhizae', 'Photosynthesis', 'Pinus', 'Plant Roots', 'Seedlings', 'Soil Pollutants'] | 15,272,714 | [['D03.383.129.578.840.374', 'D03.633.400.909.374', 'D04.345.783.374'], ['D03.383.129.578.840.374.140', 'D03.633.400.909.374.140', 'D04.345.783.374.140'], ['D01.268.556.195', 'D01.268.956.170', 'D01.552.544.195'], ['A18.400.525', 'A19.690', 'B01.300.655', 'B05.550'], ['G02.111.158.937', 'G02.111.669.700', 'G02.740.921'... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Synovial lymphocyte subsets in rheumatoid arthritis and degenerative joint disease. | There is considerable evidence to indicate that the synovitis of rheumatoid arthritis (RA) is immunologically mediated. Recently, it has been postulated that a suppressor-type cell deficiency may play an important role in the pathogenesis of the synovitis. In addition, an immune component may contribute to the synovial... | ['Adult', 'Aged', 'Aged, 80 and over', 'Antibodies, Monoclonal', 'Arthritis, Juvenile', 'Arthritis, Rheumatoid', 'Female', 'HLA-DR Antigens', 'Humans', 'Male', 'Middle Aged', 'Osteoarthritis', 'Synovitis', 'T-Lymphocytes', 'T-Lymphocytes, Helper-Inducer'] | 2,963,911 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['C05.550.114.122', 'C05.799.056', 'C17.300.775.049', 'C20.111.198'], ['C05.550.114.154', 'C05.799.114', 'C17.300.775.099', 'C20.111.199'], ['D12.776.395.550.509... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Idiopathic chronic watery diarrhea from excluded rectosigmoid with goblet cell hyperplasia cured by restoration of large bowel continuity. | A 73-year-old woman developed abnormal electrolyte and water loss from an excluded rectosigmoid segment after surgical treatment of a volvulus of the sigmoid colon. Rectal discharges lasted almost for a year, until it spontaneously resolved after restoration of large bowel continuity. Despite extensive investigation, i... | ['Aged', 'Chronic Disease', 'Colon, Sigmoid', 'Diarrhea', 'Feces', 'Female', 'Humans', 'Hyperplasia', 'Intestinal Mucosa', 'Intestine, Large', 'Postoperative Complications', 'Potassium', 'Rectum', 'Reoperation', 'Sodium'] | 3,720,472 | [['M01.060.116.100'], ['C23.550.291.500'], ['A03.556.124.526.356.668', 'A03.556.249.249.356.668'], ['C23.888.821.214'], ['A12.459'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.444'], ['A03.556.124.369', 'A10.615.550.444'], ['A03.556.124.526', 'A03.556.249.249'], ['C23.550.767'], ['D01.268.549.550', 'D01... | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Reversion of transformed glycolysis to normal by inhibition of protein synthesis in rat kidney cells infected with temperature-sensitive mutant of Rous sarcoma virus. | Normal rat kidney cells infected with a temperature-sensitive mutant (LA23) of Rous sarcoma virus exhibit the transformed phenotype when grown at 33 degrees and the normal phenotype at 39 degrees. We have previously shown [Ash, J.F., Vogt, P.K. & Singer, S.J. (1976) Proc. Natl. Acad. Sci. USA 73, 3603-3607] that the ad... | ['Aerobiosis', 'Avian Sarcoma Viruses', 'Cell Transformation, Neoplastic', 'Cell Transformation, Viral', 'Cells, Cultured', 'Dinitrophenols', 'Glycolysis', 'Oligomycins', 'Temperature', 'Time Factors'] | 217,010 | [['G02.111.017', 'G03.049'], ['B04.613.807.070.120', 'B04.820.650.070.120'], ['C04.697.098.500', 'C23.550.727.098.500'], ['C04.697.098.500.160', 'C23.550.727.098.500.160', 'G06.920.143'], ['A11.251'], ['D02.455.426.559.389.657.566.304', 'D02.640.743.304'], ['G02.111.158.750', 'G03.191.750', 'G03.295.436', 'G03.493.360'... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Chinese hamster ovary mRNA-dependent, Na(+)-independent L-leucine transport in Xenopus laevis oocytes. | In freshly prepared uninjected folliculated oocytes, Na(+)-independent leucine uptake is mediated predominantly by a system L-like transport system. Removal of follicular cells, however, results in an irreversible loss of this transport activity. When total poly(A)+ mRNA derived from Chinese hamster ovary (CHO) cells w... | ['Animals', 'Binding, Competitive', 'Biological Transport', 'CHO Cells', 'Cricetinae', 'Female', 'Kinetics', 'Leucine', 'Microinjections', 'Oocytes', 'Poly A', 'RNA, Messenger', 'Sodium', 'Substrate Specificity', 'Xenopus laevis'] | 1,360,143 | [['B01.050'], ['E05.196.080', 'G02.111.084', 'G02.111.570.120.309'], ['G03.143'], ['A11.251.210.200', 'A11.436.155'], ['B01.050.150.900.649.313.992.635.075.250'], ['G01.374.661', 'G02.111.490'], ['D12.125.070.637', 'D12.125.142.441'], ['E02.319.267.530.690', 'E05.591.570'], ['A05.360.490.690.680', 'A11.497.497.600'], [... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Synchronization dynamics of two coupled neural oscillators receiving shared and unshared noisy stimuli. | The response of neurons to external stimuli greatly depends on the intrinsic dynamics of the network. Here, the intrinsic dynamics are modeled as coupling and the external input is modeled as shared and unshared noise. We assume the neurons are repetitively firing action potentials (i.e., neural oscillators), are weakl... | ['Action Potentials', 'Algorithms', 'Computer Simulation', 'Monte Carlo Method', 'Nerve Net', 'Neural Networks, Computer', 'Neurons', 'Periodicity', 'Signal Transduction'] | 19,034,640 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['G17.035', 'L01.224.050'], ['L01.224.160'], ['E05.318.740.525', 'L01.906.394.422', 'N05.715.360.750.540', 'N06.850.520.830.525'], ['A08.511'], ['G17.485', 'L01.224.050.375.605'], ['A08.675', 'A11.671'], ['G01.910.645', 'G07.180.562'], ['G02.111.820', 'G04.835']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Expression patterns of ABA and GA metabolism genes and hormone levels during rice seed development and imbibition: a comparison of dormant and non-dormant rice cultivars. | Seed dormancy is an important agronomic trait in cereals. Using deep dormant (N22), medium dormant (ZH11), and non-dormant (G46B) rice cultivars, we correlated seed dormancy phenotypes with abscisic acid (ABA) and gibberellin (GA) metabolism gene expression profiles and phytohormone levels during seed development and i... | ['Abscisic Acid', 'Gibberellins', 'Hormones', 'Oryza', 'Plant Dormancy', 'Plant Proteins', 'Seeds', 'Transcriptome'] | 24,976,122 | [['D02.241.223.268.034', 'D02.455.326.271.665.202.061', 'D02.455.426.392.368.367.379.249.024', 'D02.455.849.131.061', 'D02.455.849.765.521.500'], ['D02.455.849.291.239.500'], ['D06.472', 'D27.505.696.399.472'], ['B01.650.940.800.575.912.250.822.616'], ['G07.345.625.875', 'G15.357.500'], ['D12.776.765'], ['A18.024.500.7... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
[Biospecific chromatography of acid proteinases. The role of ionic and hydrophobic interactions]. | Pepsin chromatography was studied on peptide ligand sorbents, differing in the length of the polypeptide chains, ionogenic groups and the nature of hydrophobic side groups. Pepsin sorption was found to be dependent of a specific interaction of the substrate analogs with the enzyme and ionic interactions with the matrix... | ['Animals', 'Cattle', 'Chromatography, Affinity', 'Chymosin', 'Ligands', 'Pepsin A', 'Peptides'] | 798,606 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['E05.196.181.400.170'], ['D08.811.277.656.074.500.200', 'D08.811.277.656.300.048.200'], ['D27.720.470.480'], ['D08.811.277.656.074.500.700', 'D08.811.277.656.300.048.700'], ['D12.644']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mixed modes of surface polaritons in a PML-type magnetoelectric multiferroic with canted spins. | We present a theoretical discussion of surface polaritons on a ferroelectric-antiferromagnet with magnetoelectric coupling which allows the magnetic subsystem to be canted. Canting of the antiferromagnet results in weak ferromagnetism. The surface polaritons for a semi-infinite film are calculated for a propagation par... | ['Computer Simulation', 'Magnetic Fields', 'Models, Chemical', 'Spin Labels'] | 22,987,867 | [['L01.224.160'], ['G01.358.750'], ['E05.599.495'], ['D02.389.678']] | ['Information Science [L]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
[Ultrasonographic diagnosis of choledocholithiasis]. | In recent years various authors have shown more than a threefold increase in us diagnosis of choledocholithiasis. To verify this premise, we examined prospectively with ultrasound, from January, 1987, to December 1990, 107 cases, all confirmed by subsequent intraoperative cholangiography. The ultrasound diagnosis was p... | ['Cholangiography', 'Evaluation Studies as Topic', 'Gallstones', 'Humans', 'Prospective Studies', 'Ultrasonography'] | 2,152,035 | [['E01.370.350.700.715.200', 'E01.370.372.200'], ['E05.337', 'N05.715.360.335'], ['C06.130.409.633', 'C06.130.564.332.500', 'C23.300.175.525'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['E01.370.350.850']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
The effect of beta-blockade on glucose tolerance and insulin release in adult diabetes. | Blood glucose and plasma insulin levels were studied in ten adult diabetics treated in a cross-over fashion for at least three weeks with alprenolol, a non-selective beta-blocker, or with metoprolol, a cardioselective beta 1-blocker. Dietary intake was controlled three days prior to the study which comprised both i.v. ... | ['Administration, Oral', 'Aged', 'Alprenolol', 'Blood Glucose', 'Diabetes Mellitus', 'Diet, Diabetic', 'Female', 'Glucose Tolerance Test', 'Humans', 'Injections, Intravenous', 'Insulin', 'Insulin Secretion', 'Male', 'Metoprolol', 'Middle Aged', 'Propanolamines'] | 7,001,862 | [['E02.319.267.100'], ['M01.060.116.100'], ['D02.033.100.624.698.055', 'D02.033.755.624.698.055', 'D02.092.063.624.698.055'], ['D09.947.875.359.448.500'], ['C18.452.394.750', 'C19.246'], ['E02.642.249.240', 'G07.203.650.240.240'], ['E01.370.225.124.100.355', 'E01.370.374.355', 'E05.200.124.100.355'], ['B01.050.150.900.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The poorly coping COPD patient: a psychotherapeutic perspective. | An etiology of maladaptive coping in Chronic Obstructive Pulmonary Disease is proposed and a model for psychotherapeutic intervention with poorly coping COPD patients is presented. Failure in mourning, manifested by a lack of shift in patient's expectations and goals leads to: 1) difficulty in accepting illness related... | ['Adaptation, Psychological', 'Behavior Therapy', 'Family Therapy', 'Grief', 'Humans', 'Lung Diseases, Obstructive', 'Psychotherapy'] | 7,263,134 | [['F01.058'], ['F04.754.137'], ['F04.754.864.581.273'], ['F01.470.142.110'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C08.381.495'], ['F04.754']] | ['Psychiatry and Psychology [F]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effect of Sodium Alginate Type on Drug Release from Chitosan-Sodium Alginate-Based In Situ Film-Forming Tablets. | Natural polymers are promising as the carrier of matrix-based sustained release tablets but limited by their diversity in source and structure properties. Our previous studies found that chitosan (CS)- and alginate (SA)-based tablets can form self-assembled polyelectrolyte complex (PEC) film on the surface, which contr... | ['Alginates', 'Chitosan', 'Drug Delivery Systems', 'Drug Liberation', 'Tablets', 'Theophylline', 'Viscosity'] | 31,907,709 | [['D09.698.068'], ['D05.750.078.139.500', 'D09.698.211.500'], ['E02.319.300'], ['G02.211', 'G03.787.321', 'G07.690.725.321'], ['D26.255.830'], ['D03.132.960.751', 'D03.633.100.759.758.824.751'], ['G02.930']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
AKT/TSC2/p70S6K signaling pathway is involved in quinocetone-induced death-promoting autophagy in HepG2 cells. | Quinocetone (QCT, 3-methyl-2-quinoxalin benzenevinylketo-1, 4-dioxide) is widely used as a veterinary drug and animal feed additive in China. Although it promotes growth and improves feed efficiency, QCT's in vitro and in vivo toxicities remain uncertain. This study was conducted to explore the mechanism of QCT-induced... | ['Anti-Bacterial Agents', 'Apoptosis', 'Autophagy', 'Blotting, Western', 'Cell Survival', 'Epithelial Cells', 'Flow Cytometry', 'Gene Knockdown Techniques', 'Hep G2 Cells', 'Hepatocytes', 'Humans', 'Microscopy, Electron, Transmission', 'Proto-Oncogene Proteins c-akt', 'Quinoxalines', 'Ribosomal Protein S6 Kinases, 70-k... | 27,098,396 | [['D27.505.954.122.085'], ['G04.146.954.035'], ['G04.011'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['G04.346'], ['A11.436'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.200.500.386.350', '... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Generation of synthetic data and experimental designs in evaluating interactions for association studies. | Complex diseases, by definition, involve multiple factors, including gene-gene interactions and gene-environment interactions. Researchers commonly rely on simulated data to evaluate their approaches for detecting high-order interactions in disease gene mapping. A publicly available simulation program to generate sampl... | ['Algorithms', 'Databases, Factual', 'Gene-Environment Interaction', 'Genotype', 'Research Design', 'Software'] | 22,809,306 | [['G17.035', 'L01.224.050'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['G05.695.337'], ['G05.380'], ['E05.581.500', 'H01.770.644.728'], ['L01.224.900']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Role of macrophage-stimulating protein and its receptor, RON tyrosine kinase, in ciliary motility. | Macrophage-stimulating protein (MSP) is an 80-kD serum protein with homology to hepatocyte growth factor (HGF). Its receptor, RON tyrosine kinase, is a new member of the HGF receptor family. The MSP-RON signaling pathway has been implicated in the functional regulation of mononuclear phagocytes. However, the function o... | ['Animals', 'Bronchi', 'Bronchoalveolar Lavage Fluid', 'Cilia', 'Epithelium', 'Fallopian Tubes', 'Female', 'Growth Substances', 'Hepatocyte Growth Factor', 'Humans', 'Macrophages, Alveolar', 'Nasal Cavity', 'Organ Specificity', 'Proto-Oncogene Proteins', 'Receptor Protein-Tyrosine Kinases', 'Receptors, Cell Surface'] | 9,045,873 | [['B01.050'], ['A04.411.125'], ['E05.927.100.500'], ['A11.284.180.165'], ['A10.272'], ['A05.360.319.114.373', 'A13.706.500'], ['D27.505.696.377'], ['D12.644.276.374.420', 'D12.776.467.374.420', 'D23.529.374.420'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.329.372.600', 'A11.627.482.600', 'A11.733.397.600',... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Schizosaccharomyces pombe pac2+ controls the onset of sexual development via a pathway independent of the cAMP cascade. | The Schizosaccharomyces pombe pac2 gene encodes a protein of 235 amino acids not similar to any protein of known function. Cells over-expressing pac2 were poor in mating and sporulation. Expression of ste11, which encodes a key transcription factor for sexual development, was not inducible by nitrogen starvation in the... | ['Amino Acid Sequence', 'Base Sequence', 'Cyclic AMP', 'DNA, Complementary', 'DNA, Fungal', 'Fungal Proteins', 'Molecular Sequence Data', 'Phenotype', 'Schizosaccharomyces', 'Schizosaccharomyces pombe Proteins', 'Transcription Factors'] | 8,536,311 | [['G02.111.570.060', 'L01.453.245.667.060'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D03.633.100.759.646.138.395', 'D13.695.462.200', 'D13.695.667.138.395', 'D13.695.827.068.395'], ['D13.444.308.497.220', 'D13.444.600.223.500', 'D27.720.470.530.600.223.260'], ['D13.444.308.300'], ['D12.776.354'], [... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Seven-senescence-associated gene signature predicts overall survival for Asian patients with hepatocellular carcinoma. | BACKGROUND: Cellular senescence is a recognized barrier for progression of chronic liver diseases to hepatocellular carcinoma (HCC). The expression of a cluster of genes is altered in response to environmental factors during senescence. However, it is questionable whether these genes could serve as biomarkers for HCC p... | ['Asian Continental Ancestry Group', 'Biomarkers, Tumor', 'Carcinoma, Hepatocellular', 'Cellular Senescence', 'Datasets as Topic', 'Female', 'Follow-Up Studies', 'Gene Expression Profiling', 'Humans', 'Kaplan-Meier Estimate', 'Liver', 'Liver Neoplasms', 'Male', 'Middle Aged', 'Models, Biological', 'Predictive Value of ... | 31,011,256 | [['M01.686.508.200'], ['D23.101.140'], ['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['G04.043'], ['E05.318.308.056', 'L01.313.500.750.300.188.400.500', 'L01.399.250.224', 'L01.470.750.750.431', 'N05.715.360.300.224', 'N06.850.520.308.056'], ['E05.318.372.500.750.249', 'N05.7... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Predictors of spontaneous viral clearance and outcomes of acute hepatitis C infection. | BACKGROUND/AIMS: This study evaluated the predictors of spontaneous viral clearance (SVC), as defined by two consecutive undetectable hepatitis C virus (HCV) RNA tests performed ? 12 weeks apart, and the outcomes of acute hepatitis C (AHC) demonstrating SVC or treatment-induced viral clearance.METHODS: Thirty-two patie... | ['Acute Disease', 'Adolescent', 'Adult', 'Aged', 'Antiviral Agents', 'Child', 'Child, Preschool', 'Female', 'Genotype', 'Hepacivirus', 'Hepatitis C', 'Humans', 'Male', 'Middle Aged', 'RNA, Viral', 'Recurrence', 'Remission, Spontaneous', 'Young Adult'] | 25,548,743 | [['C23.550.291.125'], ['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.122.388'], ['M01.060.406'], ['M01.060.406.448'], ['G05.380'], ['B04.450.380', 'B04.820.578.344.475'], ['C01.221.250.750', 'C01.925.440.440', 'C01.925.782.350.350', 'C06.552.380.705.440'], ['B01.050.150.900.649.313.988.400.112.400... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Overriding parents' medical decisions for their children: a systematic review of normative literature. | This paper reviews the ethical literature on conflicts between health professionals and parents about medical decision-making for children. We present the results of a systematic review which addressed the question 'when health professionals and parents disagree about the appropriate course of medical treatment for a c... | ['Adult', 'Child', 'Conflict, Psychological', 'Decision Making', 'Ethics, Clinical', 'Harm Reduction', 'Humans', 'Jurisprudence', 'Parental Consent', 'Personal Autonomy', 'Review Literature as Topic'] | 23,824,967 | [['M01.060.116'], ['M01.060.406'], ['F01.658.209'], ['F02.463.785.373'], ['K01.752.566.479.045.500', 'K01.752.566.479.171.132', 'N05.350.200.500', 'N05.350.340.162'], ['F01.145.477'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I01.880.604.583', 'N03.706.535'], ['I01.880.604.583.427.635.500', 'N03.706.535.489.63... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Humanities [K]', 'Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 0 |
Host age, sex, and reproductive seasonality affect nematode parasitism in wild Japanese macaques. | Parasites are characteristically aggregated within hosts, but identifying the mechanisms underlying such aggregation can be difficult in wildlife populations. We examined the influence of host age and sex over an annual cycle on the eggs per gram of feces (EPG) of nematode parasites infecting wild Japanese macaques (Ma... | ['Age Distribution', 'Animals', 'Feces', 'Female', 'Host-Parasite Interactions', 'Macaca', 'Male', 'Monkey Diseases', 'Nematoda', 'Nematode Infections', 'Parasite Egg Count', 'Reproduction', 'Seasons', 'Sex Characteristics'] | 20,711,744 | [['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['B01.050'], ['A12.459'], ['G16.527.200.400'], ['B01.050.150.900.649.313.988.400.112.199.120.510'], ['C22.735.500'], ['B01.050.500.500.294'], ['C01.610.335.508'], ['E01.370.225.932.600', 'E05.200.932.600'], ['G08.686.784'], ['G01.910.645.661', 'G16.500.275.071.590... | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
[Airbag-associated ocular trauma]. | Airbags have received widespread recognition as an effective means of enhancing automobile safety. They are particularly effective in frontal and front angle collisions which otherwise would be fatal or cause serious injuries. Inflation of the bag helps protect the driver and front-seat-passenger from hitting the steer... | ['Adult', 'Air Bags', 'Choroid', 'Eye Injuries', 'Female', 'Humans', 'Male', 'Risk Assessment', 'Rupture', 'Visual Acuity', 'Wounds, Nonpenetrating'] | 9,451,872 | [['M01.060.116'], ['E07.700.100', 'J01.637.708.100'], ['A09.371.894.223'], ['C10.900.300.284.250', 'C11.297', 'C26.915.300.425.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.600.800.715', 'N04.452.871.715', 'N05.715.360.750.625.700.690', 'N06.850.505.715', 'N06.850.520.830.600.800.715'], ['C26.76... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Examination of surface-bound Ku-DNA complexes in an aqueous environment using MAC mode atomic force microscopy. | In the development of biosensors, it is essential to understand how the signal-transducing element may perturb surface-bound proteins and nucleic acids. The tip of the atomic force microscope is such an element in atomic force microscopy. In this paper, we describe the influence of tip-sample interactions on the measur... | ['Biosensing Techniques', 'Coated Materials, Biocompatible', 'DNA Helicases', 'DNA-Binding Proteins', 'Image Interpretation, Computer-Assisted', 'Ku Autoantigen', 'Microscopy, Atomic Force', 'Nucleic Acid Conformation', 'Plasmids', 'Protein Binding', 'Protein Conformation', 'Surface Properties', 'Water'] | 15,530,788 | [['E05.601.043'], ['D25.130.420', 'J01.637.051.130.420'], ['D08.811.277.040.025.159', 'D08.811.399.340'], ['D12.776.260'], ['E01.158.600', 'E01.370.350.350', 'L01.313.500.750.100.158.600'], ['D08.811.277.040.025.159.155', 'D08.811.399.340.155', 'D12.776.157.687.493', 'D12.776.260.525', 'D12.776.660.625.625', 'D12.776.6... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Hepatic gluconeogenic capability in sepsis is depressed before changes in oxidative capability. | Since plasma alanine concentrations are markedly elevated in late sepsis and alanine is an important gluconeogenic substrate, we investigated gluconeogenic activity in intra-abdominal sepsis. Sepsis in rats was produced by cecal ligation and puncture. After 17 to 21 hours (late sepsis, LS) livers from these and sham-op... | ['Adenosine Triphosphate', 'Alanine', 'Animals', 'Bacterial Infections', 'Gluconeogenesis', 'Glucose', 'Liver', 'Male', 'Oxygen Consumption', 'Peritonitis', 'Phenylephrine', 'Rats'] | 7,120,523 | [['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['D12.125.042'], ['B01.050'], ['C01.150.252'], ['G02.111.158.500', 'G03.191.500'], ['D09.947.875.359.448'], ['A03.620'], ['G03.680'], ['C01.463.600', 'C06.844.640'], ['D02.033.100.291.617', 'D02.092.063.291.617'], ['B01.050.150.900.649.313.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Alteration in the retinoblastoma gene associated with immortalization of human fibroblasts treated with 60Co gamma rays. | Genetic analysis was carried out in human fibroblasts (KMST-6) immortalized by treatment with 60Co gamma rays in order to determine if any genetic change was involved in the immortal transformation of human cells. Analysis by restriction fragment length polymorphism revealed an alteration in chromosome 13q12-14, in whi... | ['Cell Transformation, Neoplastic', 'Cells, Cultured', 'Chromosomes, Human, Pair 13', 'Cobalt Radioisotopes', 'Fibroblasts', 'Gene Expression Regulation, Neoplastic', 'Genes, Retinoblastoma', 'Humans', 'Mutation', 'Phosphorylation', 'Polymorphism, Restriction Fragment Length', 'Precipitin Tests', 'Retinoblastoma Protei... | 8,100,822 | [['C04.697.098.500', 'C23.550.727.098.500'], ['A11.251'], ['A11.284.187.520.300.370.375', 'G05.360.162.520.300.370.375'], ['D01.268.556.185.500.354', 'D01.268.956.155.500.354', 'D01.496.239.354', 'D01.496.749.256', 'D01.552.544.185.500.354'], ['A11.329.228'], ['G05.308.370'], ['G05.360.340.024.340.375.249.400', 'G05.36... | ['Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Energy metabolism of Bdellovibrio bacteriovorus. I. Energy production, ATP pool, energy charge. | Bdellovibrio bacteriovorus, strain Bd. 109 Sa, generates ATP mainly by oxidative phosphorylation during electron transport. During exponential growth the ATP pool is constant (9 mmoles/100 mugN) indicating that energy-producing and energy-consuming reactions are well balanced. The ratio of substrate respiration/endogen... | ['Adenine Nucleotides', 'Adenosine Triphosphate', 'Aerobiosis', 'Bacteria', 'Bacteriolysis', 'Dinitrophenols', 'Electron Transport', 'Energy Metabolism', 'Glutamates', 'Iodoacetates', 'Oxidative Phosphorylation', 'Oxygen Consumption'] | 1,156,083 | [['D03.633.100.759.646.138', 'D13.695.667.138', 'D13.695.827.068'], ['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['G02.111.017', 'G03.049'], ['B03'], ['G06.099.115'], ['D02.455.426.559.389.657.566.304', 'D02.640.743.304'], ['G02.111.248', 'G03.295.531.403', 'G03.493.350'], ['G03.295'],... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Design, synthesis and evaluation of novel 2-hydroxypyrrolobenzodiazepine-5,11-dione analogues as potent angiotensin converting enzyme (ACE) inhibitors. | A series of novel 10-substituted 2-hydroxypyrrolobenzodiazepine-5,11-diones designed through structure based rational hybridization approach, synthesized by the cyclodehydration of isotonic anhydride with (2S,4R)-4-hydroxypyrrolidine-2-carboxylic acid followed by N-substitution, were evaluated as angiotensin converting... | ['Angiotensin-Converting Enzyme Inhibitors', 'Animals', 'Benzodiazepines', 'Crystallography, X-Ray', 'Dose-Response Relationship, Drug', 'Drug Design', 'HEK293 Cells', 'Humans', 'Models, Molecular', 'Pyrroles', 'Rabbits', 'Structure-Activity Relationship'] | 23,777,825 | [['D27.505.519.389.745.085'], ['B01.050'], ['D03.633.100.079.080'], ['E05.196.309.742.225'], ['G07.690.773.875', 'G07.690.936.500'], ['E05.290.500', 'H01.158.703.007.338.500', 'H01.181.466.338.500'], ['A11.251.210.172.750', 'A11.436.334'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.595'], ['D03.383.129.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Neurofibromatosis and other disorders among children with CNS tumors and their families. | We conducted a population-based case-control study with 338 patients, less than 15 years of age, diagnosed with a primary tumor of the central nervous system from January 1968 through December 1977 in 53 New York State counties. The study also included 676 controls selected from the birth certificate files of the New Y... | ['Brain Neoplasms', 'Child', 'Congenital Abnormalities', 'Epidemiologic Methods', 'Female', 'Humans', 'Male', 'Neurofibromatosis 1', 'Spinal Cord Neoplasms'] | 2,494,566 | [['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['M01.060.406'], ['C16.131'], ['E05.318', 'N06.850.520'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.580.600.580.590.650', 'C04.700.631.650', 'C10.562.600.500', 'C10.574.500.549.400', 'C10.668.829.675', 'C16.320.400.560.400', 'C16.320.700.6... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Cyanoacrylate embolization of endoleaks after abdominal aortic aneurysm repair. | INTRODUCTION: Type II endoleaks occur in up to a fifth of endoluminal repairs for abdominal aortic aneurysms and are commonly treated when aortic sac expansion can be demonstrated. Technical failure is common when catheter-guided particulates or coil embolic agents are used. Presented here is a feasibility study using ... | ['Aged', 'Aortic Aneurysm, Abdominal', 'Blood Vessel Prosthesis', 'Blood Vessel Prosthesis Implantation', 'Embolization, Therapeutic', 'Enbucrilate', 'Humans', 'Middle Aged', 'Postoperative Complications', 'Prosthesis Failure', 'Retrospective Studies', 'Ultrasonography, Doppler, Duplex'] | 20,078,537 | [['M01.060.116.100'], ['C14.907.055.239.075', 'C14.907.109.139.075'], ['E07.695.110'], ['E04.100.814.868.500', 'E04.650.200'], ['E02.520.360', 'E02.926.500'], ['D02.241.081.069.366.350', 'D02.626.290.350', 'D05.750.259.341', 'D25.720.259.341', 'D25.919.367.341', 'J01.637.051.720.259.341', 'J01.637.051.919.367.341'], ['... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Ferroportin (SLC40A1) Q248H mutation is associated with lower circulating plasma tumor necrosis factor-alpha and macrophage migration inhibitory factor concentrations in African children. | BACKGROUND: Iron deficiency and the Q248H mutation in the gene, SLC40A1, that encodes for the cellular iron exporter, ferroportin, are both common in African children. The iron status of macrophages influences the pro-inflammatory response of these cells. We hypothesized that Q248H mutation may modify the inflammatory ... | ['Africa', 'Cation Transport Proteins', 'Child', 'Child, Preschool', 'Humans', 'Infant', 'Macrophage Migration-Inhibitory Factors', 'Multivariate Analysis', 'Mutation', 'Tumor Necrosis Factor-alpha'] | 20,460,119 | [['Z01.058'], ['D12.776.157.530.450.250', 'D12.776.543.585.450.250'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['D12.644.276.374.480.625', 'D12.776.467.374.480.625', 'D23.125.477.500', 'D23.529.374.480.625'], ['E05.318.740.150.500', 'N05.715.360.750.125.500... | ['Geographicals [Z]', 'Chemicals and Drugs [D]', 'Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Genome-wide association study in Chinese cohort identifies one novel hypospadias risk associated locus at 12q13.13. | BACKGROUND: Hypospadias risk-associated gene variants have been reported in populations of European descent using genome-wide association studies (GWASs). There is little known at present about any possible hypospadias risk associations in Han Chinese populations.METHODS: To systematically investigate hypospadias risk-... | ['Alleles', 'China', 'Cohort Studies', 'Female', 'Genetic Loci', 'Genetic Predisposition to Disease', 'Genome-Wide Association Study', 'Humans', 'Hypospadias', 'Male', 'Middle Aged'] | 31,856,834 | [['G05.360.340.024.340.030'], ['Z01.252.474.164'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['G05.360.340.024.380'], ['C23.550.291.687.500', 'G05.380.355'], ['E05.318.370.392', 'E05.318.416.249', 'E05.393.385.500', 'E05.393.522.500', 'E05.393.760.640.500', 'N06.850.520.445.392', 'N... | ['Phenomena and Processes [G]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Multiplexed Population Coding of Stimulus Properties by Leech Mechanosensory Cells. | UNLABELLED: Sensory coding has long been discussed in terms of a dichotomy between spike timing and rate coding. However, recent studies found that in primate mechanoperception and other sensory systems, spike rates and timing of cell populations complement each other. They simultaneously carry information about differ... | ['Action Potentials', 'Animals', 'Biophysics', 'Leeches', 'Mechanoreceptors', 'Neurons, Afferent', 'Physical Stimulation', 'Reaction Time', 'Skin', 'Time Factors', 'Touch'] | 27,030,751 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['B01.050'], ['H01.158.344', 'H01.671.100'], ['B01.050.500.091.426'], ['A08.675.650.915.750', 'A08.800.950.750', 'A11.671.650.915.750'], ['A08.675.650', 'A11.671.650'], ['E05.723'], ['E05.796.817', 'F02.830.650', 'F04.669.817', 'G11.561.677'], ['A17.815'], ['G01.9... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Volumetric investigation of the frontal-subcortical circuitry in patients with obsessive-compulsive disorder. | The pathophysiology of obsessive-compulsive disorder (OCD) is thought to involve disturbance of the frontal-subcortical circuitry. To investigate the morphological characteristics of this circuitry, we examined the volume of the orbitofrontal cortex, anterior cingulate, thalamus, caudate, and the putamen in 36 age- and... | ['Adult', 'Brain', 'Brain Mapping', 'Case-Control Studies', 'Female', 'Frontal Lobe', 'Functional Laterality', 'Humans', 'Image Processing, Computer-Assisted', 'Imaging, Three-Dimensional', 'Magnetic Resonance Imaging', 'Male', 'Obsessive-Compulsive Disorder'] | 15,377,742 | [['M01.060.116'], ['A08.186.211'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['A08.186.211.200.885.287.500.270'], ['F02.830.297.425', 'G11.561.225.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Information Science [L]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Differential development of the stress response in congenital learned helplessness. | Early in the development of the hypothalamic-pituitary-adrenal (HPA) axis, the rat undergoes a stress hyporesponsive period of blunted responses to several stressors including cold exposure (CE) and maternal deprivation (MD). We examined the development of the axis by monitoring adrenocorticotropin hormone (ACTH) plasm... | ['Adrenocorticotropic Hormone', 'Animals', 'Cold Temperature', 'Female', 'Helplessness, Learned', 'Hypothalamo-Hypophyseal System', 'Maternal Behavior', 'Pituitary-Adrenal System', 'Pregnancy', 'Rats', 'Rats, Sprague-Dawley', 'Stress, Psychological'] | 8,237,462 | [['D06.472.699.327.935.531.500', 'D06.472.699.631.525.600.531.500', 'D12.644.400.400.935.531.500', 'D12.644.548.365.935.531.500', 'D12.644.548.691.525.690.531.500', 'D12.776.631.650.405.935.531.500'], ['B01.050'], ['G01.906.595.272', 'G16.500.275.063.725.710.300', 'G16.500.750.775.710.300', 'N06.230.300.100.725.154', '... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Quantitative studies of the discharge fields of single cells in cat striate cortex. | The configuration and width of on- and off-response zones in the discharge field of single cells in cat striate cortex was analysed by quantitative methods. The responses across on- and off-zones were plotted for 321 cells with a stationary optimum oriented light slit. The cells fell into two completely distinct subgro... | ['Action Potentials', 'Animals', 'Cats', 'Neurons', 'Photic Stimulation', 'Sympathectomy', 'Time Factors', 'Visual Cortex'] | 3,746,674 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['B01.050'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['A08.675', 'A11.671'], ['E05.723.729'], ['E04.525.210.105.800'], ['G01.910.857'], ['A08.186.211.200.885.287.500.571.735', 'A08.186.211.200.885.287.500.814.953']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A versatile test-object for the calibration of ultrasonic Doppler flow instruments. | Versatility in test-objects for ultrasonic Doppler units is desirable. The test-object described comprises a thin-walled plastic tube embedded in tissue-mimicking material. Blood is simulated using a mixture of water and glycerol with sephadex particles to act as scatterers. The test-object is suitable for use with a w... | ['Blood Flow Velocity', 'Calibration', 'Humans', 'Models, Anatomic', 'Rheology'] | 2,938,324 | [['E01.370.370.130', 'G09.330.380.630.080'], ['E05.978.155'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['J01.897.280.500.545.129', 'L01.178.820.090.545.129'], ['E05.830', 'H01.671.808']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 |
Nutritional assessment of iron status and anemia in children under 5 years old at public daycare centers. | OBJECTIVES: To assess nutritional iron status and anemia prevalence in children less than 5 years old at public daycare centers in the city of Recife, PE, Brazil.METHODS: A cross-sectional study, with a systematic random sampling of 162 children aged 6 to 59 months. Nutritional iron status was assessed in terms of body... | ['Anemia, Iron-Deficiency', 'Brazil', 'Child Day Care Centers', 'Child, Preschool', 'Cross-Sectional Studies', 'Erythropoiesis', 'Female', 'Ferritins', 'Humans', 'Infant', 'Male', 'Nutrition Surveys', 'Prevalence', 'Protoporphyrins', 'Transferrin'] | 17,676,239 | [['C15.378.071.196.300', 'C18.452.565.100'], ['Z01.107.757.176'], ['J03.160', 'N02.421.143.098'], ['M01.060.406.448'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['G04.152.825.414', 'G09.188.343.414'], ['D12.776.157.427.249', 'D12.776.556.579.249'], ['B01.050.150.900.649.313.988.400.... | ['Diseases [C]', 'Geographicals [Z]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
Cardiovascular fitness and executive control during task-switching: an ERP study. | Cardiovascular fitness recently has been linked to executive control function in older adults. The present study examined the relationship between cardiovascular fitness and executive control in young adults using event-related potentials (ERPs). Participants completed a two-part experiment. In part one, a graded exerc... | ['Adolescent', 'Adult', 'Attention', 'Brain Mapping', 'Cardiovascular System', 'Electroencephalography', 'Event-Related Potentials, P300', 'Female', 'Humans', 'Male', 'Neuropsychological Tests', 'Oxygen Consumption', 'Physical Fitness', 'Problem Solving', 'Reaction Time', 'Time Factors'] | 18,417,237 | [['M01.060.057'], ['M01.060.116'], ['F02.830.104.214'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['A07'], ['E01.370.376.300', 'E01.370.405.245'], ['G07.265.216.500.350', 'G11.561.200.500.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F04.711.513'], ['G03.680'], ['G11.427.685... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Leptospira interrogans survey by PCR in wild rodents coming from different urban areas of Palermo, Italy. | DNA extracted from the kidneys of rodents captured in different urban areas of Palermo, Italy, had been analysed for the presence of pathogenic L. interrogans sensu latu DNA. PCR analysis had shown that in rodents captured close to green areas and small river up to 40 % animals give positive PCR results. Not many cases... | ['Animal Distribution', 'Animals', 'Animals, Wild', 'Climate Change', 'DNA, Bacterial', 'DNA, Ribosomal', 'Disease Reservoirs', 'Disease Vectors', 'Ecosystem', 'Humans', 'Kidney', 'Leptospira interrogans', 'Leptospirosis', 'Mice', 'Polymerase Chain Reaction', 'RNA, Bacterial', 'RNA, Ribosomal, 16S', 'Rats', 'Risk', 'Ro... | 23,427,420 | [['F01.145.113.069', 'G16.049'], ['B01.050'], ['B01.050.050.300'], ['G16.500.175.374'], ['D13.444.308.212'], ['D13.444.308.475'], ['N06.850.520.203.250'], ['N06.850.335.188', 'N06.850.520.203.375'], ['G16.500.275.157', 'N06.230.124'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A05.810.453'], ['B03.440.400.425.4... | ['Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
ATP-dependent interaction of yeast U5 snRNA loop 1 with the 5' splice site. | Pre-messenger RNA splicing is a two-step process by which introns are removed and exons joined together. In yeast, the U5 snRNA loop 1 interacts with the 5' exon before the first step of splicing and with the 5' and 3' exons before the second step. In vitro studies revealed that yeast U5 loop 1 is not required for the ... | ['Adenosine Triphosphate', 'Base Sequence', 'DNA Primers', 'Exons', 'RNA Splicing', 'RNA, Small Nuclear', 'Saccharomyces cerevisiae', 'Transcription, Genetic'] | 11,453,062 | [['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['G05.360.340.024.340.137.232'], ['G02.111.760.700', 'G03.839.700', 'G05.308.700.700'], ['D13.444.735.628.818', 'D13.444.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Method for differential detection and identification of components in protein mixtures analyzed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. | We demonstrate that the semi-quantitative information in matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectra of tryptically digested protein mixtures can, via a systematic statistical approach, be utilized for the identification of a protein present in different concentrations in two sam... | ['Algorithms', 'Animals', 'Carbonic Anhydrases', 'Cattle', 'Complex Mixtures', 'Cytochromes c', 'Data Interpretation, Statistical', 'Hemoglobins', 'Horses', 'Models, Chemical', 'Models, Statistical', 'Myoglobin', 'Peptide Mapping', 'Proteins', 'Reproducibility of Results', 'Sensitivity and Specificity', 'Spectrometry, ... | 15,378,717 | [['G17.035', 'L01.224.050'], ['B01.050'], ['D08.811.520.241.300.150'], ['B01.050.150.900.649.313.500.380.271'], ['D20'], ['D08.244.286.100', 'D12.776.422.220.286.100'], ['E05.245.380', 'E05.318.740.300', 'L01.313.500.750.190.380', 'N05.715.360.750.300', 'N06.850.520.830.300'], ['D12.776.124.400', 'D12.776.422.316.762']... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Inhibitor scaffold for the histone lysine demethylase KDM4C (JMJD2C). | The human histone demethylases of the KDM4 (JMJD2) family have been associated to diseases such as prostate and breast cancer, as well as X-linked mental retardation. Therefore, these enzymes are considered oncogenes and their selective inhibition might be a possible therapeutic approach to treat cancer. Here we descri... | ['Dose-Response Relationship, Drug', 'Drug Design', 'Enzyme Inhibitors', 'Humans', 'Jumonji Domain-Containing Histone Demethylases', 'Molecular Structure', 'Pyrazoles', 'Small Molecule Libraries', 'Structure-Activity Relationship'] | 22,917,519 | [['G07.690.773.875', 'G07.690.936.500'], ['E05.290.500', 'H01.158.703.007.338.500', 'H01.181.466.338.500'], ['D27.505.519.389'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.682.662.582.475.500', 'D08.811.682.690.416.388'], ['G02.111.570', 'G02.466'], ['D03.383.129.539'], ['D27.720.470.765'], ['G02.111.83... | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Obstetric and perinatal outcomes in women ?40years of age: Associations with fetal growth disorders. | BACKGROUND: Evidence indicates that advanced maternal age is associated with adverse obstetric and perinatal outcomes. The purpose of this study was to evaluate pregnancy outcomes in women of advanced maternal age (?40years).METHODS: Using a prospective study design, data were collected by the Department of Obstetrics ... | ['Adult', 'Birth Weight', 'Cesarean Section', 'Female', 'Fetal Growth Retardation', 'Fetal Macrosomia', 'Humans', 'Maternal Age', 'Pregnancy', 'Pregnancy Complications', 'Pregnancy Outcome', 'Pregnancy in Diabetics', 'Premature Birth', 'Prospective Studies'] | 27,391,869 | [['M01.060.116'], ['C23.888.144.186', 'E01.370.600.115.100.160.120.186', 'E05.041.124.160.750.149', 'G07.100.100.160.120.186', 'G07.345.249.314.120.186'], ['E04.520.252.500'], ['C13.703.277.370', 'C16.300.390', 'C23.550.393.450'], ['C13.703.170.500', 'C13.703.277.570', 'C13.703.726.570', 'C16.300.570', 'C19.246.099.968... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A multicenter randomized crossover multiple-dose comparison study of arotinolol and propranolol in essential tremor. | BACKGROUND: A new medication is needed to treat essential tremor. Preliminary evidence suggests that arotinolol may be effective in the treatment of this disorder.OBJECTIVE: To study the effect of arotinolol and propranolol in a crossover, multiple dose comparative trial of patients with essential tremor.PATIENTS AND M... | ['Adrenergic beta-Antagonists', 'Adult', 'Aged', 'Aged, 80 and over', 'Cross-Over Studies', 'Essential Tremor', 'Female', 'Humans', 'Male', 'Middle Aged', 'Propanolamines', 'Propranolol', 'Psychomotor Performance', 'Task Performance and Analysis', 'Treatment Outcome'] | 12,853,233 | [['D27.505.519.625.050.200.200', 'D27.505.696.577.050.200.200'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.318.370.150', 'N05.715.360.325.150', 'N06.850.520.445.150'], ['C10.228.662.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['D02.033.100.624', 'D02.033.755.6... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Studies on the chemical constituents from Xinjiang Punica granatum]. | OBJECTIVE: To study the chemical constituents from Punica granatum.METHODS: The chemical constituents were isolated by column chromatography on silica gel and MCI-gel CHP 20P, Sephadex LH-20. Their structures were elucidated on the basis of spectral analysis and physical constants.RESULTS: Ten compounds were isolated a... | ['Catechin', 'Ellagic Acid', 'Fruit', 'Gallic Acid', 'Lythraceae', 'Magnetic Resonance Spectroscopy', 'Molecular Structure', 'Oleanolic Acid', 'Plant Bark', 'Plants, Medicinal'] | 19,565,710 | [['D03.383.663.283.240.190', 'D03.383.663.283.266.450.206', 'D03.633.100.150.240.190', 'D03.633.100.150.266.450.206'], ['D03.383.663.283.500', 'D03.633.100.150.500'], ['A18.024.500', 'G07.203.300.562', 'J02.500.562'], ['D02.241.223.100.300.200', 'D02.241.511.390.200', 'D02.455.426.559.389.127.281.200', 'D02.455.426.559... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Nitrogen requirements in severely injured patients. | The study was designed to evaluate nitrogen needs in severely injured patients during the first week after trauma. Thirty-nine patients aged from 18 to 65 years with a burn or fractures of more than two long bones were studied. Energy requirements were given parenterally as fat and glucose in isocaloric amounts. The pa... | ['Adolescent', 'Adult', 'Body Weight', 'Burns', 'Creatinine', 'Female', 'Fractures, Bone', 'Humans', 'Male', 'Methylhistidines', 'Middle Aged', 'Multiple Trauma', 'Nitrogen', 'Nutritional Requirements', 'Parenteral Nutrition, Total', 'Random Allocation'] | 2,111,195 | [['M01.060.057'], ['M01.060.116'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['C26.200'], ['D03.383.129.308.207'], ['C26.404'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.125.072.329.539'], ['M01.060.116.630'], ['C26.640'], ['D01.268... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Correlation and prognostic significance of beta-galactoside alpha-2,6-sialyltransferase and serum monosialylated alpha-fetoprotein in hepatocellular carcinoma. | AIM: To investigate the correlation between tissue ST6Gal I and serum msAFP in HCC patients, and to investigate their prognostic significance.METHODS: Preoperative sera, paired tumorous and non-tumorous tissues were collected from 19 consecutive patients who had undergone surgical resection of HCC. ST6Gal I activities ... | ['Antigens, CD', 'Carcinoma, Hepatocellular', 'Humans', 'Liver Neoplasms', 'Microsomes, Liver', 'Prognosis', 'Retrospective Studies', 'Sialyltransferases', 'Statistics as Topic', 'Survival Rate', 'alpha-Fetoproteins'] | 16,425,369 | [['D23.050.301.264.035', 'D23.101.100.110'], ['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.274.623', 'C06.301.623', 'C06.552.697'], ['A11.284.835.540.541'], ['E01.789'], ['E05.318.372.500.500.500', 'E05.318.372.500.75... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Image-based Characterization of 3D Collagen Networks and the Effect of Embedded Cells. | Collagen microstructure is closely related to the mechanical properties of tissues and affects cell migration through the extracellular matrix. To study these structures, three-dimensional (3D) in vitro collagen-based gels are often used, attempting to mimic the natural environment of cells. Some key parameters of the ... | ['Biomechanical Phenomena', 'Cell Line', 'Cell Movement', 'Chemical Phenomena', 'Collagen', 'Humans', 'Hydrogels', 'Imaging, Three-Dimensional', 'Microscopy, Confocal', 'Microscopy, Fluorescence', 'Tissue Engineering', 'Tissue Scaffolds'] | 31,210,124 | [['G01.154.090', 'G01.374.089'], ['A11.251.210'], ['G04.198', 'G07.568.500.180'], ['G02'], ['D05.750.078.280', 'D12.776.860.300.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D20.280.320.375', 'D26.255.165.320.375'], ['E01.370.350.400', 'L01.224.308.410'], ['E01.370.350.515.395', 'E05.595.395'], ['E01.370.35... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Antagonism in isolated equine digital vessels of contraction induced by epinephrine in the presence of hydrocortisone and an aqueous extract of black walnut (Juglans nigra). | Prazosin, isoxsuprine, and nifedipine were screened for ability to reverse contraction of isolated equine digital vascular strips produced by epinephrine (Epi) in the presence of hydrocortisone (Hc) and an aqueous extract of black walnut (Juglans nigra) (BW). Two arteries and two veins from each of three horses for eac... | ['Animals', 'Chi-Square Distribution', 'Epinephrine', 'Horses', 'Hydrocortisone', 'Isoxsuprine', 'Muscle Contraction', 'Muscle, Smooth, Vascular', 'Nifedipine', 'Plant Extracts', 'Prazosin', 'Trees'] | 2,614,858 | [['B01.050'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['D02.033.100.291.310', 'D02.092.063.291.310', 'D02.092.211.215.454', 'D02.092.311.461', 'D02.455.426.559.389.657.166.175.461'], ['B01.050.150.900.649.313.984.235.472'], ['D04.210.500.745.745.654.600', 'D06.472.0... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Effect of energy substrates on protein degradation in isolated small intestinal enterocytes from rats. | BACKGROUND: Nutrients affect small intestinal protein mass and metabolism, but studies on the effect of nutrients on small intestinal protein degradation are very limited due to a lack of a proper method. The objectives of this study were to establish a method to directly estimate protein degradation in isolated entero... | ['3-Hydroxybutyric Acid', 'Analysis of Variance', 'Animals', 'Cell Survival', 'Cells, Cultured', 'Energy Metabolism', 'Enterocytes', 'Glucose', 'Glutamine', 'Intestine, Small', 'Male', 'Osmolar Concentration', 'Proteins', 'Rats', 'Rats, Sprague-Dawley', 'Tyrosine'] | 17,047,174 | [['D02.241.081.114.937.349', 'D02.241.511.429.349', 'D02.522.585.087', 'D10.251.400.143.781.500'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['B01.050'], ['G04.346'], ['A11.251'], ['G03.295'], ['A03.556.124.369.290', 'A10.615.550.444.290', 'A11.436.290'], ['D09.947.875.359.448'], ['D12.125.068.... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Assisted migration to address climate change: recommendations for aspen reforestation in western Canada. | Human-aided movement of species populations in large-scale reforestation programs could be a potent and cost-effective climate change adaptation strategy. Such large-scale management interventions, however, tend to entail the risks of unintended consequences, and we propose that three conditions should be met before im... | ['Adaptation, Physiological', 'Canada', 'Climate Change', 'Demography', 'Ecosystem', 'Environmental Monitoring', 'Models, Theoretical', 'Populus', 'Remote Sensing Technology', 'Seeds', 'Trees'] | 21,830,704 | [['G07.025', 'G16.012.500'], ['Z01.107.567.176'], ['G16.500.175.374'], ['I01.240', 'N01.224', 'N06.850.505.400'], ['G16.500.275.157', 'N06.230.124'], ['N06.850.460.350.080', 'N06.850.780.375'], ['E05.599'], ['B01.650.940.800.575.912.250.859.797.875.453'], ['E01.370.520.750.500', 'E05.925.500', 'L01.178.847.675.500'], [... | ['Phenomena and Processes [G]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Information Science [L]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 |
Palliative gastrectomy is beneficial in selected cases of metastatic gastric cancer. | BACKGROUND: Salvage chemotherapy is the mainstay of treatment for metastatic gastric cancer (mGC). This study aimed to clarify the effects of palliative gastrectomy (PG) and identify prognostic factors in mGC patients undergoing PG.METHODS: This was a retrospective review of 333 mGC patients receiving PG or a non-resec... | ['Adult', 'Aged', 'Aged, 80 and over', 'Female', 'Gastrectomy', 'Humans', 'Male', 'Middle Aged', 'Palliative Care', 'Prognosis', 'Retrospective Studies', 'Salvage Therapy', 'Stomach Neoplasms', 'Survival Analysis', 'Young Adult'] | 28,288,593 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E04.210.419'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E02.760.666', 'N02.421.585.666'], ['E01.789'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N0... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Cryopreservation of human spermatozoa: an assessment of methodology using rhodamine 123. | Rhodamine 123 fluorescent labeling of the human spermatozoal midpiece was used as a means of monitoring spermatozoal viability. This simple procedure was used in three separate studies to establish differential spermatozoal survival. Twenty ejaculates of reasonable quality were taken from men attending the Cromwell Hos... | ['Cell Survival', 'Culture Media', 'Freezing', 'Humans', 'Male', 'Rhodamine 123', 'Rhodamines', 'Semen Preservation', 'Spermatozoa', 'Xanthenes'] | 3,606,271 | [['G04.346'], ['D27.720.470.305', 'E07.206'], ['G01.645.500', 'G01.906.595.272.437', 'G02.734.466'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.633.300.953.600.500'], ['D03.633.300.953.600'], ['E02.792.833.890', 'E05.760.833.890'], ['A05.360.490.890', 'A11.497.760'], ['D03.633.300.953']] | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The incidence of ulcerative keratitis among aphakic contact lens wearers in New England. | We conducted a population-based incidence study in five New England states to quantify the risk of ulcerative keratitis associated with contact lens use among aphakic persons. All practicing ophthalmologists in the five-state area were surveyed to identify prospectively all new cases of ulcerative keratitis during a 4-... | ['Adolescent', 'Adult', 'Aphakia, Postcataract', 'Child', 'Contact Lenses', 'Contact Lenses, Extended-Wear', 'Contact Lenses, Hydrophilic', 'Corneal Ulcer', 'Female', 'Humans', 'Incidence', 'Male', 'Middle Aged', 'New England', 'Prospective Studies', 'Random Allocation', 'Risk Factors'] | 1,987,926 | [['M01.060.057'], ['M01.060.116'], ['C11.510.103.110'], ['M01.060.406'], ['E07.632.500.276'], ['E07.632.500.276.360.220'], ['E07.632.500.276.360'], ['C01.375.177', 'C11.204.564.225', 'C11.294.177'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
A PXR reporter gene assay in a stable cell culture system: CYP3A4 and CYP2B6 induction by pesticides. | A stable hepatoma cell line expressing the human pregnane X receptor (hPXR) and the cytochrome P4503A4 (CYP3A4) distal and proximal promoters plus the luciferase reporter gene was developed to assess the ability of several xenobiotic agents to induce CYP3A4 and CYP2B6. After selection for neomycin resistance, one clone... | ['Aryl Hydrocarbon Hydroxylases', 'Cytochrome P-450 CYP2B6', 'Cytochrome P-450 CYP3A', 'Cytochrome P-450 Enzyme System', 'Enzyme Induction', 'Genes, Reporter', 'Hepatocytes', 'Humans', 'Oxidoreductases, N-Demethylating', 'Pesticides', 'Pregnane X Receptor', 'Receptors, Cytoplasmic and Nuclear', 'Receptors, Steroid', 'T... | 15,548,381 | [['D08.244.453.005', 'D08.811.682.690.708.170.010', 'D12.776.422.220.453.010'], ['D08.244.453.005.575', 'D08.244.453.491.344', 'D08.811.682.690.708.170.010.575', 'D08.811.682.690.708.170.450.344', 'D12.776.422.220.453.010.575', 'D12.776.422.220.453.491.344'], ['D08.244.453.860.500', 'D08.811.682.662.582.353', 'D08.811.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effect of chronic ETA-selective endothelin receptor antagonism on blood pressure in experimental and genetic hypertension in rats. | 1. Chronic treatment with a combined ETA/ETB endothelin receptor antagonist has been shown to reduce blood pressure in experimental rat models of hypertension in which endothelin-1 gene overexpression occurs in the walls of blood vessels, particularly small, resistance-sized arteries, but not in those genetic or experi... | ['Animals', 'Antihypertensive Agents', 'Atrasentan', 'Blood Pressure', 'Desoxycorticosterone', 'Dose-Response Relationship, Drug', 'Endothelin Receptor Antagonists', 'Endothelins', 'Hemodynamics', 'Hypertension', 'Hypertension, Renovascular', 'Male', 'Phenylpropionates', 'Pyrimidines', 'Pyrrolidines', 'Rats', 'Rats, In... | 9,222,550 | [['B01.050'], ['D27.505.954.411.162'], ['D03.383.246.118.300', 'D03.383.773.079', 'D03.633.100.115.300'], ['E01.370.600.875.249', 'G09.330.380.076'], ['D04.210.500.745.745.654.339', 'D06.472.040.585.611'], ['G07.690.773.875', 'G07.690.936.500'], ['D27.505.519.364'], ['D12.644.276.400', 'D12.776.467.400', 'D23.529.400']... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Selective fimbria and thalamic lesions differentially impair forms of working memory in rats. | Several series of experiments were designed to compare the effects of selective lesions of the fimbria or of thalamic nuclei on three different tasks involving working memory in rats: object recognition, place recognition, and the radial arm maze test. The main effects of fimbria lesions were as follows: they produced ... | ['Animals', 'Brain Mapping', 'Discrimination Learning', 'Form Perception', 'Hippocampus', 'Male', 'Mental Recall', 'Neural Pathways', 'Orientation', 'Rats', 'Rats, Inbred Strains', 'Retention, Psychology', 'Septum Pellucidum', 'Thalamic Nuclei'] | 1,759,943 | [['B01.050'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['F02.463.425.280'], ['F02.463.593.373', 'F02.463.593.778.435'], ['A08.186.211.180.405', 'A08.186.211.200.885.287.500.345'], ['F02.463.425.540.641'], ['A08.612'], ['F01.058.577', 'F02.830.606'], ['B01.050.150.900.649.313.992.635.50... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Oxidative modification of M-type K(+) channels as a mechanism of cytoprotective neuronal silencing. | Voltage-gated K(+) channels of the Kv7 family underlie the neuronal M current that regulates action potential firing. Suppression of M current increases excitability and its enhancement can silence neurons. We here show that three of five Kv7 channels undergo strong enhancement of their activity by oxidative modificati... | ['Animals', 'CHO Cells', 'Cell Hypoxia', 'Cell Survival', 'Cricetinae', 'Cricetulus', 'Dose-Response Relationship, Drug', 'Gene Silencing', 'Glucose', 'Humans', 'Hydrogen Peroxide', 'KCNQ Potassium Channels', 'Membrane Potentials', 'Models, Neurological', 'Neurodegenerative Diseases', 'Neurons', 'Oxidants', 'Oxidation-... | 17,024,175 | [['B01.050'], ['A11.251.210.200', 'A11.436.155'], ['G03.197.300', 'G04.270.300'], ['G04.346'], ['B01.050.150.900.649.313.992.635.075.250'], ['B01.050.150.900.649.313.992.635.075.250.250'], ['G07.690.773.875', 'G07.690.936.500'], ['G05.308.203.374'], ['D09.947.875.359.448'], ['B01.050.150.900.649.313.988.400.112.400.400... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Human T lymphocyte phenotypes after bone marrow transplantation. T cells expressing Ia-like antigen. | Peripheral blood Ia-positive (Ia+) T cells were enumerated in 52 patients who had received allogeneic or syngeneic bone marrow transplantation for the treatment of acute leukemia or severe aplastic anemia. Twenty-two normal people showed 3 +/- 2% of peripheral blood T cells to be Ia+. During the first 130 days posttran... | ['Acute Disease', 'Adult', 'Anemia, Aplastic', 'Bone Marrow Transplantation', 'Graft vs Host Reaction', 'Histocompatibility Antigens Class II', 'Humans', 'Leukemia', 'Phenotype', 'T-Lymphocytes'] | 6,351,369 | [['C23.550.291.125'], ['M01.060.116'], ['C15.378.071.085', 'C15.378.190.223.250'], ['E02.095.147.725.040', 'E04.936.580.040'], ['G12.875.402'], ['D12.776.395.550.509', 'D12.776.543.550.440', 'D23.050.301.500.400', 'D23.050.705.552.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.337'], ['G05.695'], ['A... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
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