Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Mutagenicity of commercial Monascus fermentation products and the role of citrinin contamination. | Pigments produced as secondary metabolites by various isolates of moulds belonging to the genus Monascus have been used traditionally as colorants in Oriental food. Modern food industry has rediscovered these moulds as promising source for natural colorants. However, recent studies evidence that one of the secondary me... | ['Animals', 'Ascomycota', 'Biotransformation', 'Cells, Cultured', 'Chromatography, High Pressure Liquid', 'Citrinin', 'Drug Contamination', 'Female', 'Fermentation', 'Food Coloring Agents', 'Food Contamination', 'In Vitro Techniques', 'Liver', 'Male', 'Microsomes, Liver', 'Mutagenicity Tests', 'Mutagens', 'Rats', 'Rats... | 10,477,335 | [['B01.050'], ['B01.300.107'], ['G03.171', 'G03.787.225', 'G07.690.725.225'], ['A11.251'], ['E05.196.181.400.300'], ['D03.383.663.283.320', 'D03.633.100.150.320', 'D23.946.587.272'], ['N06.850.360'], ['G02.111.158.249', 'G03.191.249'], ['D27.720.233.674', 'D27.720.372.300.355'], ['J01.576.423.850.730.500.249', 'N06.850... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Development and implementation of an LGBT initiative at a health sciences library: the first eighteen months. | Background: The University of Louisville School of Medicine is the pilot site for the eQuality project, an initiative to integrate training for providing care to lesbian, gay, bisexual, and transgender (LGBT) patients into the standard medical school curriculum. Inspired by and in support of this School of Medicine ini... | ['Curriculum', 'Female', 'Humans', 'Librarians', 'Libraries, Medical', 'Library Science', 'Male', 'Program Evaluation', 'Schools, Medical', 'Sexual and Gender Minorities', 'Transgender Persons'] | 31,607,812 | [['I02.158'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.526.555'], ['J03.400.596.831.937', 'L01.346.596.719.875'], ['L01.583'], ['E05.337.820', 'N04.761.685', 'N05.715.360.650'], ['I02.783.495.552', 'N02.278.020.578'], ['M01.777'], ['M01.777.500']] | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Named Groups [M]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 |
Abnormality of catecholamines balance relating to social deviance. | Approximately a quarter of maximum security hospital patients convicted of highly deviant crimes exhibited low 'anxiety-type' psychophysiological responsivity to stressors together with an abnormal catecholamine balance during stressor anticipation which resulted in noradrenalin to adrenalin ratios in excess of 5.5, an... | ['Adolescent', 'Adult', 'Antisocial Personality Disorder', 'Anxiety', 'Creatinine', 'Criminal Psychology', 'Epinephrine', 'Fear', 'Humans', 'Male', 'Middle Aged', 'Norepinephrine', 'Prisoners', 'Stress, Psychological'] | 917,715 | [['M01.060.057'], ['M01.060.116'], ['F03.675.050'], ['F01.470.132'], ['D03.383.129.308.207'], ['F02.784.240'], ['D02.033.100.291.310', 'D02.092.063.291.310', 'D02.092.211.215.454', 'D02.092.311.461', 'D02.455.426.559.389.657.166.175.461'], ['F01.470.361'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Does influenza vaccination of older adult Medicare beneficiaries lower treatment costs for acute and chronic respiratory disease? | BACKGROUND: Influenza accounts for a large proportion of hospitalizations and deaths among older adults, resulting in substantial health care expenses. Influenza vaccinations are effective in reducing respiratory infections in younger populations, but it is less certain whether they reduce costs associated with respira... | ['Acute Disease', 'Aged', 'Aged, 80 and over', 'Chronic Disease', 'Cost Savings', 'Female', 'Health Care Surveys', 'Humans', 'Influenza Vaccines', 'Influenza, Human', 'Male', 'Medicare', 'Middle Aged', 'Regression Analysis', 'Respiratory Tract Diseases', 'United States'] | 20,624,610 | [['C23.550.291.125'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C23.550.291.500'], ['N03.219.151.160.200'], ['E05.318.308.980.344', 'N03.349.380.210', 'N05.425.210', 'N05.715.360.300.800.344', 'N06.850.520.308.980.344'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D20.215.894.899.302'], ['C01.748.310', 'C0... | ['Diseases [C]', 'Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Analysis of Long-Chain Unsaturated Fatty Acids by Ionic Liquid Gas Chromatography. | Four ionic liquid (IL) columns, SLB-IL59, SLB-IL60, SLB-IL65, and SLB-IL111, were evaluated for more rapid analysis or improved resolution of long-chain methyl and ethyl esters of omega-3, omega-6, and additional positional isomeric and stereoisomeric blends of fatty acids found in fish oil, flaxseed oil, and potential... | ['Chromatography, Gas', 'Dietary Supplements', 'Esters', 'Fatty Acids, Unsaturated', 'Fish Oils', 'Stereoisomerism'] | 26,852,774 | [['E05.196.181.349'], ['G07.203.300.456', 'J02.500.456'], ['D02.241.400'], ['D10.251.355'], ['D10.627.430'], ['G02.607.445.682']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Lower metabolic rate in individuals heterozygous for either a frameshift or a functional missense MC4R variant. | OBJECTIVE: Humans with functional variants in the melanocortin 4 receptor (MC4R) are obese, hyperphagic, and hyperinsulinemic but have been reported to have no difference in energy expenditure.RESEARCH DESIGN AND METHODS: We investigated the association of two MC4R variants, Arg165Gln (R165Q) and A insertion at nucleot... | ['Amino Acid Substitution', 'Arginine', 'Arizona', 'Basal Metabolism', 'Body Mass Index', 'DNA Transposable Elements', 'Frameshift Mutation', 'Genetic Carrier Screening', 'Genetic Variation', 'Glutamine', 'Humans', 'Hyperinsulinism', 'Hyperphagia', 'Indians, North American', 'Mutation, Missense', 'Obesity', 'Polymorphi... | 18,835,933 | [['E05.393.420.601.035', 'G05.558.109'], ['D12.125.068.050', 'D12.125.095.104', 'D12.125.142.087'], ['Z01.107.567.875.760.100'], ['G03.295.154'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['D13.444.308.520', 'G02.111.570.080.708.330.200', 'G05.360.080.708.330.200', 'G... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Mouse Cytomegalovirus Differentially Exploits Cell Surface Glycosaminoglycans in a Cell Type-Dependent and MCK-2-Independent Manner. | Many viruses initiate interaction with target cells by binding to cell surface glycosaminoglycans (GAGs). Heparan sulfate (HS) appears to be particularly important in fibroblasts, epithelial cells and endothelial cells, where it represents the dominant GAG. How GAGs influence viral infectivity in HS-poor target cells s... | ['Animals', 'Cell Line', 'Chemokines, CC', 'Chondroitin Sulfates', 'Fibroblasts', 'Host Microbial Interactions', 'Macrophages', 'Mice', 'Mice, Inbred BALB C', 'Muromegalovirus', 'RAW 264.7 Cells', 'Viral Proteins', 'Viral Tropism', 'Virus Internalization'] | 31,892,128 | [['B01.050'], ['A11.251.210'], ['D12.644.276.374.200.110', 'D12.776.467.374.200.110', 'D23.125.300.110', 'D23.469.200.110', 'D23.529.374.200.110'], ['D09.698.373.200.300'], ['A11.329.228'], ['G06.373', 'G16.527'], ['A11.329.372', 'A11.627.482', 'A11.733.397', 'A15.382.670.522', 'A15.382.680.397'], ['B01.050.150.900.649... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Subjective signs of efficacious inferior alveolar nerve block in children. | This study is designed to examine the clinical signs relating to profound anesthesia of the primary dentition using the inferior alveolar nerve block (IANB) injection. The IANB injection has been used for many years for both adults and children to anesthetize the mandibular teeth. Most dentists are quite familiar with ... | ['Anesthesia, Dental', 'Child', 'Child, Preschool', 'Cold Temperature', 'Crowns', 'Dental Restoration, Permanent', 'Gingiva', 'Humans', 'Lip', 'Mandibular Nerve', 'Nerve Block', 'Pulpotomy', 'Sensation', 'Time Factors', 'Tongue', 'Touch'] | 2,212,195 | [['E03.155.141', 'E06.045'], ['M01.060.406'], ['M01.060.406.448'], ['G01.906.595.272', 'G16.500.275.063.725.710.300', 'G16.500.750.775.710.300', 'N06.230.300.100.725.154', 'N06.230.300.100.725.710.300'], ['E06.780.346.250', 'E07.695.190.088'], ['E06.323.428', 'E06.780.346.737', 'E07.695.190.190'], ['A14.549.167.646.480... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anatomy [A]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Primary hyperparathyroidism and osteosarcoma: examination of a large cohort identifies three cases of fibroblastic osteosarcoma. | UNLABELLED: To study a possible relationship between hyperparathyroidism and osteosarcoma, we reviewed 1234 osteosarcoma patients. In this cohort, only three patients had a diagnosis of both hyperparathyroidism and fibroblastic osteosarcoma. These results indicate that hyperparathyroidism is not more prevalent in patie... | ['Adolescent', 'Age Factors', 'Aged', 'Bone Neoplasms', 'Cohort Studies', 'Female', 'Humans', 'Hyperparathyroidism', 'Hyperparathyroidism, Primary', 'Male', 'Middle Aged', 'Norway', 'Osteitis', 'Osteosarcoma', 'Prevalence', 'Risk Factors'] | 16,059,628 | [['M01.060.057'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['C04.588.149', 'C05.116.231'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C19.642.355'], ['C19.642.355.239'], ['M01.060.116.630'], ['Z01.542.816.374'], [... | ['Named Groups [M]', 'Health Care [N]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Lung cancer and mesothelioma among engine room crew--case reports with risk assessment of previous and ongoing exposure to carcinogens. | OBJECTIVE: The aim of this article is to illustrate, by means of case reports on occupational exposure in four men with cancer, the hazards of previous and ongoing carcinogenic exposures in ships' engine rooms. Several cases of cancer occurred within a few years among the engine room crew of a passenger ferry. An inves... | ['Adolescent', 'Adult', 'Air Pollutants, Occupational', 'Asbestos', 'Carcinogens', 'Humans', 'Lung Neoplasms', 'Male', "Men's Health", 'Mesothelioma', 'Middle Aged', 'Occupational Diseases', 'Occupational Exposure', 'Polycyclic Aromatic Hydrocarbons', 'Risk Assessment', 'Risk Factors', 'Ships', 'Sweden'] | 18,350,972 | [['M01.060.057'], ['M01.060.116'], ['D27.888.284.101.268'], ['D01.578.725.050', 'D01.837.725.700.760.070'], ['D27.888.569.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['N01.400.425'], ['C04.557.470.035.510', 'C04.557.470.660.510'], ['M01.060.116.630'], [... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
Inactivation of the srtA gene in Streptococcus gordonii inhibits cell wall anchoring of surface proteins and decreases in vitro and in vivo adhesion. | The srtA gene product, SrtA, has been shown to be required for cell wall anchoring of protein A as well as virulence in the pathogenic bacterium Staphylococcus aureus. There are five major mechanisms for displaying proteins at the surface of gram-positive bacteria (P. Cossart and R. Jonquieres, Proc. Natl. Acad. Sci. U... | ['Aminoacyltransferases', 'Animals', 'Antigens, Bacterial', 'Bacterial Adhesion', 'Bacterial Outer Membrane Proteins', 'Bacterial Proteins', 'Carrier Proteins', 'Cell Wall', 'Cysteine Endopeptidases', 'Fibronectins', 'Genes, Bacterial', 'Mice', 'Mouth Mucosa', 'Streptococcus'] | 11,119,491 | [['D08.811.913.050.200'], ['B01.050'], ['D23.050.161'], ['G06.099.050'], ['D12.776.097.120', 'D12.776.543.100'], ['D12.776.097'], ['D12.776.157'], ['A11.284.183'], ['D08.811.277.656.262.500', 'D08.811.277.656.300.200'], ['D12.776.377.715.390', 'D12.776.395.550.350', 'D12.776.543.550.350', 'D12.776.860.300.450'], ['G05.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[The value of Doppler echocardiography in the diagnosis of pulmonary artery hypertension in chronic obstructive bronchopneumopathies]. | We report a study using Doppler echocardiography looking for pulmonary arterial hypertension (HTAP) in 36 patients presenting with chronic airflow obstruction (BPCO) who are in a stable state. 18 of these (group 1) had confirmed HTAP by right heart catheterisation which had been done the day before and was defined as a... | ['Adult', 'Aged', 'Blood Pressure', 'Cardiac Catheterization', 'Echocardiography', 'Female', 'Heart Failure', 'Humans', 'Hypertension, Pulmonary', 'Lung Diseases, Obstructive', 'Male', 'Middle Aged', 'Pulmonary Artery', 'Systole'] | 3,217,590 | [['M01.060.116'], ['M01.060.116.100'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E01.370.370.380.140', 'E02.148.442', 'E05.157.250'], ['E01.370.350.130.750', 'E01.370.350.850.220', 'E01.370.370.380.220'], ['C14.280.434'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C08.381.423', 'C14.907.489.556'], ['C08.381... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Quantitative analysis of the gastrointestinal flora in the piglet prior and after weaning with special reference to the pathogenesis of Coli-enterotoxemia]. | The gastro-intestinal flora of clinically intact piglets on an industrialised sow unit was investigated prior to weaning (n = 12) and after weaning (n = 12). The age of the former group was 23 to 36 days and that of the latter between six and eleven days. While enormous proliferation of haemolysing E. coli was recorded... | ['Animals', 'Digestive System', 'Escherichia coli', 'Escherichia coli Infections', 'Gastrointestinal Diseases', 'Swine', 'Swine Diseases', 'Time Factors', 'Weaning'] | 332,111 | [['B01.050'], ['A03'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['C01.150.252.400.310.330'], ['C06.405'], ['B01.050.150.900.649.313.500.880'], ['C22.905'], ['G01.910.857'], ['G07.203.650.220.500.750', 'G07.203.650.915']] | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Studies on ABH antigen grouping of ammoniacal extracts of bloodstains by absorption-elution. | The effects of absorption time, titer of antiserum or lectin in the absorption stage, and elution temperature on relative antibody or lectin yield in elutes in the absorption-elution procedure were studied in bloodstains and ammoniacal extracts of bloodstains using conventional grouping reagents. In addition, monoclona... | ['ABO Blood-Group System', 'Antibodies, Monoclonal', 'Blood Stains', 'Humans', 'Immunosorbent Techniques', 'Temperature'] | 3,527,900 | [['D23.050.301.290.031', 'D23.050.705.230.031'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['I01.198.780.937.206'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.478.566.380', 'E05.601.470.380'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.71... | ['Chemicals and Drugs [D]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Incidence of heart failure in 6083 elderly hypertensive patients: the Second Australian National Blood Pressure Study (ANBP2). | AIMS: Hypertension is a known risk factor for the development of heart failure (HF); however, few data are available on the magnitude of short- and long-term progression from hypertension to HF. The present study aims to determine the short- and long-term incidence of HF, and identify factors associated with onset of H... | ['Aged', 'Aged, 80 and over', 'Antihypertensive Agents', 'Australia', 'Comorbidity', 'Diabetes Mellitus', 'Disease Progression', 'Female', 'Follow-Up Studies', 'Heart Failure', 'Humans', 'Hypertension', 'Incidence', 'Male', 'Outcome and Process Assessment, Health Care', 'Prognosis', 'Risk Factors', 'Sex Factors', 'Smok... | 26,508,441 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.954.411.162'], ['Z01.639.100', 'Z01.678.100.373'], ['N05.715.350.225', 'N06.850.490.687'], ['C18.452.394.750', 'C19.246'], ['C23.550.291.656'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['C14.280.434'], ['B01.050.1... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Health Care [N]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Hypouricemia related to a hypersecretional tubulopathy. | We present 1 patient with hypouricemia and hyperuricosuria. Serum uric acid level ranged between 1.5 and 1.9 mg/dl and uric acid fractional excretion between 20 and 28%. Apart from that the renal function was normal. The pyrazinamide suppression test gave a normal response showing nearly complete suppression of urate e... | ['Adult', 'Depression, Chemical', 'Extracellular Space', 'Female', 'Furosemide', 'Humans', 'Kidney Function Tests', 'Kidney Tubules', 'Meningitis, Viral', 'Pyrazinamide', 'Sulfinpyrazone', 'Uric Acid'] | 6,877,462 | [['M01.060.116'], ['G07.690.773.750'], ['A10.082.500', 'A11.284.295'], ['D02.065.884.725.300', 'D02.092.146.807.300', 'D02.886.590.700.725.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.390.400'], ['A05.810.453.736.560'], ['C01.207.245.500', 'C01.925.182.550', 'C10.228.228.245.500', 'C10.228.614.400'... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The role of fur in the acid tolerance response of Salmonella typhimurium is physiologically and genetically separable from its role in iron acquisition. | The response of Salmonella typhimurium to low pH includes a low-pH protection system called the acid tolerance response (ATR). The iron-regulatory protein Fur has been implicated in the ATR since fur mutants are acid sensitive and cause altered expression of several acid shock proteins (J. W. Foster, J. Bacteriol. 173:... | ['Acids', 'Adaptation, Physiological', 'Amino Acid Sequence', 'Bacterial Proteins', 'Base Sequence', 'Biological Transport', 'Enterobactin', 'Gene Expression Regulation, Bacterial', 'Hydrogen-Ion Concentration', 'Iron', 'Molecular Sequence Data', 'Mutation', 'Repressor Proteins', 'Salmonella typhimurium', 'Sequence Hom... | 8,824,613 | [['D01.029'], ['G07.025', 'G16.012.500'], ['G02.111.570.060', 'L01.453.245.667.060'], ['D12.776.097'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G03.143'], ['D04.345.566.352', 'D12.125.154.800.937', 'D12.644.641.352'], ['G05.308.300'], ['G02.300'], ['D01.268.556.412', 'D01.268.956.287', 'D01.552.544.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Relationship of MTHFR and NQO1 Pharmacogenetics and Chemotherapy Clinical Outcomes in Breast Cancer Patients. | The study aimed at evaluating the influence of MTHFR 677C>T and NQO1 609C>T polymorphisms in toxicity and response to chemotherapy in breast cancer patients. These two genes are involved in the folate homeostasis and bioactivation of chemotherapeutic drugs, respectively. In this study, 243 patients treated with FEC/FAC... | ['Antimetabolites, Antineoplastic', 'Breast Neoplasms', 'Female', 'Humans', 'Methotrexate', 'Methylenetetrahydrofolate Reductase (NADPH2)', 'NAD(P)H Dehydrogenase (Quinone)', 'Neoplasm Staging', 'Polymorphism, Single Nucleotide', 'Treatment Outcome'] | 26,014,925 | [['D27.505.519.186.144', 'D27.505.954.248.144', 'D27.888.569.042.030'], ['C04.588.180', 'C17.800.090.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.633.100.733.631.192.500'], ['D08.811.682.662.290', 'D12.776.331.775'], ['D08.811.682.608.800.500'], ['E01.789.625'], ['G05.365.795.598'], ['E01.789.800', 'N0... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Sternal nourishment in various conditions of vascularization. | BACKGROUND: Early changes in sternal perfusion were studied after midline sternotomy and different methods of mammary artery (MA) harvesting.METHODS: Our observations were made in the swine model after midline sternotomy. In group 1 (6 animals), after unilateral skeletonized MA harvesting, (99m)Tc particles were inject... | ['Animals', 'Coronary Artery Bypass', 'Female', 'Mammary Arteries', 'Regional Blood Flow', 'Sternum', 'Swine'] | 15,797,076 | [['B01.050'], ['E04.100.376.719.332', 'E04.100.814.868.750', 'E04.928.220.520.220'], ['A07.015.114.891.525'], ['G09.330.100.780'], ['A02.835.232.570.750'], ['B01.050.150.900.649.313.500.880']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Novel mechanism of hexamer ring assembly in protein/RNA interactions revealed by single molecule imaging. | Many nucleic acid-binding proteins and the AAA+ family form hexameric rings, but the mechanism of hexamer assembly is unclear. It is generally believed that the specificity in protein/RNA interaction relies on molecular contact through a surface charge or 3D structure matching via conformational capture or induced fit.... | ['Bacillus Phages', 'Base Sequence', 'Capsid', 'Capsid Proteins', 'DNA Packaging', 'Molecular Sequence Data', 'Mutation', 'Protein Binding', 'RNA, Viral', 'RNA-Binding Proteins', 'Terminology as Topic', 'Virion', 'Virus Assembly'] | 18,940,870 | [['B04.123.100'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A21.249.500.250'], ['D12.776.964.970.600.550'], ['G04.400', 'G05.213'], ['L01.453.245.667'], ['G05.365.590'], ['G02.111.679', 'G03.808'], ['D13.444.735.828'], ['D12.776.157.725', 'D12.776.664.962'], ['L01.559.598.400'], ['A21.249'], ['G06.92... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Health-related quality of life and treatment satisfaction in North American patients with primary immunedeficiency diseases receiving subcutaneous IgG self-infusions at home. | The lifelong IgG replacement therapy for patients with primary immunedeficiencies (PIDD) may be provided by intravenous (IVIG) or by subcutaneous IgG (SCIG) infusions. We investigated the impact of weekly SCIG self-infusions at home on the health-related quality of life, treatment satisfaction, and preferences in patie... | ['Adult', 'Canada', 'Child', 'Female', 'Home Infusion Therapy', 'Humans', 'Immunoglobulin G', 'Immunologic Deficiency Syndromes', 'Injections, Subcutaneous', 'Longitudinal Studies', 'Male', 'Patient Satisfaction', 'Quality of Life', 'Self Administration', 'Sensitivity and Specificity', 'United States'] | 16,418,804 | [['M01.060.116'], ['Z01.107.567.176'], ['M01.060.406'], ['E02.319.444', 'N02.421.143.524.436'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.124.486.485.114.619.393', 'D12.776.124.790.651.114.619.393', 'D12.776.377.715.548.114.619.393'], ['C20.673'], ['E02.319.267.530.620'], ['E05.318.372.500.750.500', 'N... | ['Named Groups [M]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Phenomena a... | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Acute onset of dizziness caused by a cavernous malformation lateral to the fourth ventricle: a case report. | Dizziness, diplopia, and nystagmus may be nonspecific symptoms and in part attributed to central causes. We report a case with brain stem lesion and discuss these nonspecific symptoms. A 13-year-old boy presented to our emergency department with a lasting dizziness for 1 week and diplopia for 5 days. New onset horizont... | ['Acute Disease', 'Adolescent', 'Brain Neoplasms', 'Diplopia', 'Dizziness', 'Hemangioma, Cavernous, Central Nervous System', 'Humans', 'Male', 'Nystagmus, Pathologic'] | 21,524,634 | [['C23.550.291.125'], ['M01.060.057'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['C10.597.751.941.339', 'C11.966.339', 'C23.888.592.763.941.339'], ['C23.888.592.763.237'], ['C04.557.645.375.385.500', 'C10.500.190.200', 'C14.240.850.875.249', 'C14.907.454.385.500', 'C15.378.463.515.385.500', 'C16.1... | ['Diseases [C]', 'Named Groups [M]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Changes in protein spectrum of cattle blood serum with lympholeukosis]. | The protein spectrum of blood serum was studied in healthy cows and those suffering from leucosis. The total amount of protein at the early stages of the disease is established to be unchanged. But with lympholeucosis the content of the globulin fraction increases with a simultaneous decrease in the amount of albumins ... | ['Animals', 'Blood Proteins', 'Cattle', 'Cattle Diseases', 'Immunoglobulin G', 'Leukemia', 'Serum Albumin, Bovine', 'Serum Globulins', 'Time Factors'] | 898,320 | [['B01.050'], ['D12.776.124'], ['B01.050.150.900.649.313.500.380.271'], ['C22.196'], ['D12.776.124.486.485.114.619.393', 'D12.776.124.790.651.114.619.393', 'D12.776.377.715.548.114.619.393'], ['C04.557.337'], ['D12.776.034.841.540', 'D12.776.124.727.875'], ['D12.776.124.790', 'D12.776.377.715'], ['G01.910.857']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Allogeneic murine melanoma cell vaccine: a model for the development of human allogeneic cancer vaccine. | In an attempt to induce an immune response against tumour antigens, several groups are transfecting cytokine and other genes into autologous tumour cells which are given to the patient as a vaccine. This process is labour-intensive, time-consuming and expensive. Allogeneic cells would offer a more convenient vehicle fo... | ['Animals', 'Cancer Vaccines', 'Disease Models, Animal', 'Female', 'Flow Cytometry', 'Histocompatibility Antigens Class I', 'Histocompatibility Antigens Class II', 'Humans', 'Melanoma, Experimental', 'Mice', 'Mice, Inbred C3H', 'Mice, Inbred C57BL', 'Tumor Cells, Cultured'] | 8,873,049 | [['B01.050'], ['D20.215.894.200'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.200.500.386.350', 'E05.242.363.342', 'E05.242.386.350'], ['D12.776.395.550.489', 'D12.776.543.550.439', 'D23.050.301.500.100... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mammotome-assisted removal with minimal incision of large juvenile fibroadenoma of breast: A case report. | INTRODUCTION: Giant juvenile breast fibroadenoma can cause deformity and should be excised. Cosmesis is an important consideration in young patients.PATIENT CONCERNS: The patient was admitted to our hospital for a mass of 6 ? 6 cm in her left breast.DIAGNOSE: A giant juvenile fibroadenoma.INTERVENTIONS: With the help o... | ['Breast Neoplasms', 'Female', 'Fibroadenoma', 'Humans', 'Mammaplasty', 'Minimally Invasive Surgical Procedures', 'Monitoring, Intraoperative', 'Patient Satisfaction', 'Ultrasonography, Doppler', 'Young Adult'] | 32,150,097 | [['C04.588.180', 'C17.800.090.500'], ['C04.557.450.565.590.595.350', 'C04.557.470.625.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.218.565', 'E04.680.500'], ['E04.502'], ['E01.370.520.510', 'E04.510'], ['F01.100.150.750.625', 'F01.145.488.887.625', 'N04.452.822.700', 'N05.300.150.800.625', 'N05.715.360... | ['Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A comparison of anxiolytic and nonanxiolytic agents in the shock-probe/burying test for anxiolytics. | The effects of IP midazolam (1.0-3.0 mg/kg), pentobarbital (10-20 mg/kg), ethanol (500-2000 mg/kg), scopolamine (0.05-1.25 mg/kg), chlorpromazine (0.5-5.0 mg/kg), yohimbine (0.5-2.0 mg/kg), and pentylene-tetrazol (5.0-20.0 mg/kg) were compared in the shock-probe/burying test. Consistent with results found previously fo... | ['Animals', 'Anti-Anxiety Agents', 'Anxiety', 'Behavior, Animal', 'Male', 'Rats', 'Rats, Inbred Strains'] | 1,971,951 | [['B01.050'], ['D27.505.696.277.950.015', 'D27.505.954.427.210.950.015', 'D27.505.954.427.700.872.015'], ['F01.470.132'], ['F01.145.113'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760', 'B01.050.150.900.649.313.992.635.505.700.400']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The inverse relationship between cost and prognosis. | While doctors get the blame for increasing medical costs, studies how that societal, political factors, and medicine's limitations are the culprit. Clinicians (I use the term to distinguish between those M.D.s who work at the bedside and others who are in nonpatient direct care) are well aware of the hugh costs associa... | ['Community Participation', 'Costs and Cost Analysis', 'Delivery of Health Care', 'Economics, Medical', 'Health Education', 'Humans', 'Prognosis', 'United States'] | 6,700,349 | [['N02.421.143.212', 'N03.540.245.360'], ['N03.219.151'], ['N04.590.374', 'N05.300'], ['N03.219.300'], ['I02.233.332', 'N02.421.726.407'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.789'], ['Z01.107.567.875']] | ['Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Stronger seasonal adjustment in leaf turgor loss point in lianas than trees in an Amazonian forest. | Pan-tropically, liana density increases with decreasing rainfall and increasing seasonality. This pattern has led to the hypothesis that lianas display a growth advantage over trees under dry conditions. However, the physiological mechanisms underpinning this hypothesis remain elusive. A key trait influencing leaf and ... | ['Adaptation, Physiological', 'Droughts', 'French Guiana', 'Osmotic Pressure', 'Plant Leaves', 'Seasons', 'Trees', 'Tropical Climate', 'Water'] | 28,077,687 | [['G07.025', 'G16.012.500'], ['G16.500.175.781', 'G16.500.750.775.154', 'N06.230.100.230.150'], ['Z01.107.757.435'], ['G01.374.715.578', 'G02.640.249', 'G02.723.661'], ['A18.024.812'], ['G01.910.645.661', 'G16.500.275.071.590', 'N06.230.300.100.250.525'], ['B01.650.915'], ['G16.500.275.071.600', 'N06.230.300.100.250.60... | ['Phenomena and Processes [G]', 'Health Care [N]', 'Geographicals [Z]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
A randomized clinical trial of the effectiveness of a Web-based health behaviour change support system and group lifestyle counselling on body weight loss in overweight and obese subjects: 2-year outcomes. | BACKGROUND: Weight loss can prevent and treat obesity-related diseases. However, lost weight is usually regained, returning to the initial or even higher levels in the long term. New counselling methods for maintaining lifestyle changes are urgently needed.OBJECTIVES: An information and communication technology-based h... | ['Adult', 'Counseling', 'Female', 'Health Promotion', 'Humans', 'Internet', 'Life Style', 'Male', 'Middle Aged', 'Obesity', 'Overweight', 'Treatment Outcome', 'Weight Reduction Programs', 'Young Adult'] | 29,974,563 | [['M01.060.116'], ['F02.784.176', 'F04.408.413', 'N02.421.143.303', 'N02.421.461.363'], ['I02.233.332.445', 'N02.421.726.407.579'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.230.110.500'], ['F01.829.458'], ['M01.060.116.630'], ['C18.654.726.500', 'C23.888.144.699.500', 'E01.370.600.115.100.160.120.699.... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Information Science [L]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 0 |
Predominance of the mutation at 1138 of the cDNA for the fibroblast growth factor receptor 3 in Japanese patients with achondroplasia. | Fibroblast growth factor receptor 3 (FGFR3) has recently been identified as a putative gene for achondroplasia. Since a guanine to adenine mutation at 1138 of the cDNA for FGFR3 had been identified in most of the patients in Western population, we examined 13 Japanese patients to see if they also share the same mutatio... | ['Achondroplasia', 'Humans', 'Japan', 'Point Mutation', 'Protein-Tyrosine Kinases', 'Receptor, Fibroblast Growth Factor, Type 3', 'Receptors, Fibroblast Growth Factor'] | 8,851,771 | [['C05.116.099.343.110', 'C05.116.099.708.017', 'C16.320.240.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.474.463', 'Z01.639.595'], ['G05.365.590.675'], ['D08.811.913.696.620.682.725'], ['D08.811.913.696.620.682.725.400.179', 'D12.776.543.750.630.442', 'D12.776.543.750.750.400.370.875', 'D12.776.62... | ['Diseases [C]', 'Organisms [B]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Public health consequences of the J-curve hypothesis of alcohol problems. | This paper addresses some issues related to the hypothesis that the risk for premature death is a J-shaped function of alcohol intake. The first part of the paper contains a discussion of the individual level epidemiological evidence. It is argued that the evidence is not yet good enough to allow precise statements abo... | ['Adult', 'Aged', 'Alcohol Drinking', 'Alcoholism', 'Cause of Death', 'Coronary Disease', 'Dose-Response Relationship, Drug', 'Female', 'Health Education', 'Humans', 'Male', 'Middle Aged', 'Public Health', 'Risk Factors', 'Sweden'] | 8,867,196 | [['M01.060.116'], ['M01.060.116.100'], ['F01.145.317.269'], ['C25.775.100.250', 'F03.900.100.350'], ['E05.318.308.985.550.250', 'N01.224.935.698.100', 'N06.850.505.400.975.550.250', 'N06.850.520.308.985.550.250'], ['C14.280.647.250', 'C14.907.585.250'], ['G07.690.773.875', 'G07.690.936.500'], ['I02.233.332', 'N02.421.7... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Geographica... | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Two related thrombin-like enzymes present in Bothrops atrox venom. | This article describes the presence of two new forms of a thrombin-like enzyme, both with apparent molecular masses of 38 kDa, in Bothrops atrox venom. Both share the ability to cleave fibrinogen into fibrin and to digest casein. Both present identical K(m) on the substrate BApNA. Their N-terminal amino acid sequences ... | ['Animals', 'Blood Coagulation', 'Blotting, Western', 'Bothrops', 'Crotalid Venoms', 'Electrophoresis, Polyacrylamide Gel', 'Fibrinogen', 'Isoenzymes', 'Precipitin Tests', 'Thrombin'] | 11,050,658 | [['B01.050'], ['G09.188.390.150'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['B01.050.150.900.833.672.125.937.240.375'], ['D20.888.850.960.200', 'D23.946.833.850.960.200'], ['E05.196.401.402', 'E05.301.300.319'], ['D12.776.124.050.250', 'D12.776.124.125.500', ... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Dietary á-linolenic acid inhibits arterial thrombus formation, tissue factor expression, and platelet activation. | OBJECTIVE: Plant-derived á-linolenic acid (ALA) may constitute an attractive cardioprotective alternative to fish-derived n-3 fatty acids. However, the effect of dietary ALA on arterial thrombus formation remains unknown.METHODS AND RESULTS: Male C57Bl/6 mice were fed a high-ALA or low-ALA diet for 2 weeks. Arterial th... | ['Animals', 'Cardiotonic Agents', 'Carotid Arteries', 'Carotid Artery Thrombosis', 'Cells, Cultured', 'Dietary Supplements', 'Endothelial Cells', 'Gene Expression', 'Humans', 'MAP Kinase Kinase Kinase 5', 'MAP Kinase Signaling System', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Myocytes, Smooth Muscle', 'NF-kappa B', 'Plat... | 21,571,683 | [['B01.050'], ['D27.505.954.411.222', 'D27.720.799.080'], ['A07.015.114.186'], ['C10.228.140.300.200.355', 'C14.907.253.123.355', 'C14.907.253.566.206', 'C14.907.355.590.213.206'], ['A11.251'], ['G07.203.300.456', 'J02.500.456'], ['A11.436.275'], ['G05.297'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.9... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
The presence and cytotoxicity of CD16+ CD2- subset from PBL and NK cells in long-term IL-2 cultures enhanced by Prothymosin-alpha. | The aim of this study was to characterize the LAK cell subpopulation on which Prothymosin-alpha (ProT alpha) exerts its enhancing effect on cytotoxicity. We investigated the role of ProT alpha on LAK induction from peripheral blood lymphocytes (PBL) and NK-enriched cells, both cultured for 5 weeks with IL-2 and ProT al... | ['Antigens, CD', 'Antigens, Differentiation, T-Lymphocyte', 'CD2 Antigens', 'CD56 Antigen', 'CD8 Antigens', 'Cell Separation', 'Cells, Cultured', 'Cytotoxicity, Immunologic', 'Dose-Response Relationship, Drug', 'Flow Cytometry', 'Humans', 'Interleukin-2', 'Killer Cells, Lymphokine-Activated', 'Killer Cells, Natural', '... | 7,542,644 | [['D23.050.301.264.035', 'D23.101.100.110'], ['D23.050.301.264.894', 'D23.101.100.894'], ['D23.050.301.264.894.090', 'D23.101.100.894.090'], ['D12.776.395.550.200.250.520.156', 'D12.776.543.550.200.250.520.156', 'D23.050.301.264.894.156', 'D23.050.301.350.250.520.156', 'D23.101.100.894.156'], ['D23.050.301.264.894.108'... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Inhibition of beta interferon transcription by noncytopathogenic bovine viral diarrhea virus is through an interferon regulatory factor 3-dependent mechanism. | The induction and inhibition of the interferon (IFN) response and apoptosis by bovine viral diarrhea virus (BVDV) has been examined. Here we show that prior infection of cells by noncytopathogenic BVDV (ncp BVDV) fails to block transcriptional responses to alpha/beta IFN. In contrast, ncp BVDV-infected cells fail to pr... | ['Animals', 'Apoptosis', 'Cattle', 'Cells, Cultured', 'Cytopathogenic Effect, Viral', 'DNA-Binding Proteins', 'Diarrhea Viruses, Bovine Viral', 'GTP-Binding Proteins', 'Interferon Regulatory Factor-3', 'Interferon-beta', 'Myxovirus Resistance Proteins', 'Proteins', 'RNA, Double-Stranded', 'Semliki forest virus', 'Trans... | 12,186,882 | [['B01.050'], ['G04.146.954.035'], ['B01.050.150.900.649.313.500.380.271'], ['A11.251'], ['E01.370.225.500.384.235', 'E05.200.500.384.235', 'E05.242.384.235', 'G06.920.190'], ['D12.776.260'], ['B04.820.578.344.700.150'], ['D08.811.277.040.330.300', 'D12.776.157.325'], ['D12.644.360.024.302.374', 'D12.776.157.057.050.37... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Phenotypic comparison between mesothelial and microvascular endothelial cell lineages using conventional endothelial cell markers, cytoskeletal protein markers and in vitro assays of angiogenic potential. | Endothelial and mesothelial cells are mesodermally derived simple squamous epithelial cells. A controversy concerning the ontogenetic origin of neoplasms derived from these cell types, commonly cited in the literature, is whether Kaposi's sarcoma is a mesothelioma or an angioma. To assess the similarities and differenc... | ['Actins', 'Animals', 'Antigens', 'Biomarkers', 'Cattle', 'Cells, Cultured', 'Cytoskeletal Proteins', 'Cytoskeleton', 'Endothelium, Vascular', 'Lung', 'Mesoderm', 'Myocardium', 'Neovascularization, Pathologic', 'Peptidyl-Dipeptidase A', 'Phenotype', 'Tropomyosin', 'Tubulin', 'Vimentin', 'von Willebrand Factor'] | 2,482,821 | [['D05.750.078.730.250', 'D12.776.210.500.100', 'D12.776.220.525.255'], ['B01.050'], ['D23.050'], ['D23.101'], ['B01.050.150.900.649.313.500.380.271'], ['A11.251'], ['D12.776.220'], ['A11.284.430.214.190.750'], ['A07.015.700.500', 'A10.272.491.355'], ['A04.411'], ['A16.504.660'], ['A02.633.580', 'A07.541.704', 'A10.690... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mycobacterium tuberculosis causing infection of an implantable biventricular defibrillator. | Mycobacterial infection of implantable cardiac devices is rare, and infection of pacing system components with M. tuberculosis has been reported on only three previous occasions, involving epicardial pacing systems in two cases. We report here a pocket infection with M. tuberculosis in a transvenous biventricular defib... | ['Aged', 'Defibrillators, Implantable', 'Humans', 'Male', 'Prosthesis-Related Infections', 'Tuberculosis'] | 21,141,340 | [['M01.060.116.100'], ['E07.305.250.159.175', 'E07.305.250.319.175', 'E07.695.202.175'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C01.685', 'C23.550.767.868'], ['C01.150.252.410.040.552.846']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Lack of association between antiphospholipid antibodies and first-trimester spontaneous abortion: prospective study of pregnancies detected within 21 days of conception. | OBJECTIVE: To determine the role of antiphospholipid antibodies and anticardiolipin antibodies in first-trimester losses, addressing experimental pitfalls that preclude excluding the possibility that these antibodies reflect merely the selection bias of studying couples only after they have already experienced losses.D... | ['Abortion, Spontaneous', 'Adolescent', 'Adult', 'Antibodies, Antiphospholipid', 'Female', 'Humans', 'Pregnancy', 'Pregnancy Trimester, First', 'Prospective Studies'] | 9,591,485 | [['C13.703.039', 'G08.686.784.769.496.125'], ['M01.060.057'], ['M01.060.116'], ['D12.776.124.486.485.114.323.210', 'D12.776.124.790.651.114.323.210', 'D12.776.377.715.548.114.323.210'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G08.686.784.769'], ['G08.686.707.408'], ['E05.318.372.500.750.625', 'N05.715.360.33... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
An epitope common to gangliosides O-acetyl-GD3 and GD3 recognized by antibodies in melanoma patients after active specific immunotherapy. | GD3 is a major ganglioside of human melanoma and was shown to be an effective target for passive immunotherapy with murine monoclonal antibodies. It was noted earlier that GD3 neither purified nor in melanoma cell vaccine (MCV), could elicit an antibody response in melanoma patients. In this study, we demonstrate that ... | ['Antibodies', 'Antibody Specificity', 'Antigens, Neoplasm', 'Enzyme-Linked Immunosorbent Assay', 'Epitopes', 'Fluorescent Antibody Technique', 'Gangliosides', 'Humans', 'Immunotherapy', 'Melanoma', 'Vaccines'] | 2,472,199 | [['D12.776.124.486.485.114', 'D12.776.124.790.651.114', 'D12.776.377.715.548.114'], ['G12.100'], ['D23.050.285'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['D23.050.550'], ['E01.370.225.500.607.512.240', 'E01.370.225.750.551.512.240', 'E05.200.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Compensatory growth renders Tcf7l1a dispensable for eye formation despite its requirement in eye field specification. | The vertebrate eye originates from the eye field, a domain of cells specified by a small number of transcription factors. In this study, we show that Tcf7l1a is one such transcription factor that acts cell-autonomously to specify the eye field in zebrafish. Despite the much-reduced eye field in tcf7l1a mutants, these f... | ['Animals', 'Cell Proliferation', 'Embryo, Nonmammalian', 'Eye', 'Female', 'Gene Expression Regulation, Developmental', 'Genetic Loci', 'Kinetics', 'Male', 'Morphogenesis', 'Mutation', 'Neural Plate', 'Neurogenesis', 'Penetrance', 'Phenotype', 'Prosencephalon', 'Transcription Factor 7-Like 1 Protein', 'Up-Regulation', ... | 30,777,146 | [['B01.050'], ['G04.161.750', 'G07.345.249.410.750'], ['A13.350', 'A16.331'], ['A01.456.505.420', 'A09.371'], ['G05.308.310'], ['G05.360.340.024.380'], ['G01.374.661', 'G02.111.490'], ['G07.345.500'], ['G05.365.590'], ['A16.629'], ['G04.152.912', 'G07.345.500.325.377.687', 'G08.686.784.170.450.500', 'G11.561.620'], ['G... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Rescue of the recombinant infectious bronchitis virus with the ectodomain region of H120 spike glycoprotein]. | To explore the expression potential of heterogeneous genes using the backbone of infectious bronchitis virus (IBV) Beaudette strain, the ectodomain region of the Spike gene (1,302 bp) of IBV H120 strain was amplified by RT-PCR and replaced into the corresponding location of the IBV Beaudette strain full-length cDNA. Th... | ['Animals', 'Chick Embryo', 'Chickens', 'Chlorocebus aethiops', 'Coronavirus Infections', 'Infectious bronchitis virus', 'Poultry Diseases', 'Protein Structure, Tertiary', 'Spike Glycoprotein, Coronavirus', 'Transfection', 'Vero Cells'] | 25,868,282 | [['B01.050'], ['A13.350.150', 'A16.331.200'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['B01.050.150.900.649.313.988.400.112.199.120.126.110'], ['C01.925.782.600.550.200'], ['B04.820.578.500.540.150.400.750'], ['C22.131.728'], ['G02.111.570.820.709.610'], ['D12.776.543.512.500.665', 'D12.776.964.... | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The novel complex combination of alum, CpG ODN and HH2 as adjuvant in cancer vaccine effectively suppresses tumor growth in vivo. | Single-component adjuvant is prone to eliciting a specific type of Th1 or Th2 response. So, the development of combinatorial adjuvants inducing a robust mixed Th1/Th2 response is a promising vaccination strategy against cancer. Here, we describe a novel combination of aluminum salts (alum), CpG oligodeoxynucleotide (Cp... | ['Adjuvants, Immunologic', 'Alum Compounds', 'Animals', 'Antigens', 'Cancer Vaccines', 'Cell Line, Tumor', 'Cell Proliferation', 'Cytokines', 'Disease Models, Animal', 'Humans', 'Immunization', 'Lymphocytes, Tumor-Infiltrating', 'MAP Kinase Signaling System', 'Mice', 'NF-kappa B', 'Neoplasms', 'Oligodeoxyribonucleotide... | 28,515,346 | [['D27.505.696.477.067'], ['D01.056.025', 'D01.875.800.800.850.025'], ['B01.050'], ['D23.050'], ['D20.215.894.200'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.161.750', 'G07.345.249.410.750'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['B01.050.150.900.649... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Spatial and temporal attention deficits following brain injury: a neuroanatomical decomposition of the temporal order judgement task. | We investigated spatial and temporal deficits following brain injury using the temporal order judgement (TOJ) task. Patients judged the order in which two letters appeared to the left and right of fixation. We measured the extent of any spatial bias and the temporal resolution of the decision. Temporal and spatial defi... | ['Aged', 'Aged, 80 and over', 'Attention', 'Brain', 'Brain Injuries', 'Case-Control Studies', 'Female', 'Humans', 'Judgment', 'Male', 'Middle Aged', 'Neuroimaging', 'Neuropsychological Tests', 'Space Perception', 'Time Perception'] | 23,088,557 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['F02.830.104.214'], ['A08.186.211'], ['C10.228.140.199', 'C10.900.300.087', 'C26.915.300.200'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.785.626'], ['M01.060.116.630'], ['E01.... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Randomized controlled trial of skin-to-skin contact from birth versus conventional incubator for physiological stabilization in 1200- to 2199-gram newborns. | AIM: Conventional care of prematurely born infants involves extended maternal-infant separation and incubator care. Recent research has shown that separation causes adverse effects. Maternal-infant skin-to-skin contact (SSC) provides an alternative habitat to the incubator, with proven benefits for stable prematures; t... | ['Anxiety, Separation', 'Birth Weight', 'Female', 'Gestational Age', 'Heart Rate', 'Humans', 'Incubators, Infant', 'Infant Care', 'Infant, Low Birth Weight', 'Infant, Newborn', 'Infant, Premature', 'Male', 'Mother-Child Relations', 'Oxygen Consumption', 'Respiration', 'Skin'] | 15,244,227 | [['F03.080.300', 'F03.625.047'], ['C23.888.144.186', 'E01.370.600.115.100.160.120.186', 'E05.041.124.160.750.149', 'G07.100.100.160.120.186', 'G07.345.249.314.120.186'], ['G07.345.500.325.235.968', 'G08.686.320'], ['E01.370.600.875.500', 'G09.330.380.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E07.325.569... | ['Psychiatry and Psychology [F]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]', 'Named Groups [M]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Metabolic regulation of the K(ATP) and a maxi-K(V) channel in the insulin-secreting RINm5F cell. | K channels in the cell membrane of the insulin-secreting RINm5F cell line were studied using the patch-clamp technique in cell-attached patch mode. With 140 mM K in the pipette, two channels displaying different conductive and kinetics properties were observed. A voltage-independent, inward-rectifying, 55-pS channel wa... | ['Adenosine Triphosphate', 'Animals', 'Cell Line', 'Electric Conductivity', 'Glucose', 'Insulin', 'Insulin Secretion', 'Islets of Langerhans', 'Kinetics', 'Membrane Potentials', 'Potassium Channels'] | 3,049,931 | [['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['B01.050'], ['A11.251.210'], ['G01.358.500.249.277'], ['D09.947.875.359.448'], ['D06.472.699.587.200.500.625', 'D12.644.548.586.200.500.625'], ['G03.442', 'G07.475'], ['A03.734.414', 'A06.300.414'], ['G01.374.661', 'G02.111.490'], ['G01.15... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Zidovudine prophylaxis for needlestick exposure to human immunodeficiency virus: a decision analysis. | OBJECTIVE: To perform a decision analysis to determine the thresholds of safety and effectiveness that would justify short-term zidovudine (AZT) administration for persons with accidental percutaneous exposure to HIV-positive blood.DESIGN: Published data were used to estimate the seroconversion rate (0.42%), rate of de... | ['Acquired Immunodeficiency Syndrome', 'Decision Support Techniques', 'Health Workforce', 'Humans', 'Needles', 'Occupational Diseases', 'Risk Factors', 'Wounds, Stab', 'Zidovudine'] | 2,179,491 | [['C01.221.250.875.040', 'C01.221.812.640.400.040', 'C01.778.640.400.040', 'C01.925.782.815.616.400.040', 'C01.925.813.400.040', 'C01.925.839.040', 'C20.673.480.040'], ['E05.245', 'L01.313.500.750.190'], ['N02.350', 'N04.452.525.500', 'N05.300.420.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E07.612'], ['C... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Automated DNA diagnostics using an ELISA-based oligonucleotide ligation assay. | DNA diagnostics, the detection of specific DNA sequences, will play an increasingly important role in medicine as the molecular basis of human disease is defined. Here, we demonstrate an automated, nonisotopic strategy for DNA diagnostics using amplification of target DNA segments by the polymerase chain reaction (PCR)... | ['Base Sequence', 'DNA', 'Enzyme-Linked Immunosorbent Assay', 'Genetic Linkage', 'Haplotypes', 'Humans', 'Molecular Sequence Data', 'Oligonucleotides', 'Polymerase Chain Reaction', 'Polymorphism, Genetic', 'Robotics'] | 2,247,466 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D13.444.308'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['G05.348'], ['G05.380.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.453.245.667'], ['D13.695.578.424'], ['E05... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 |
Would vaccination against nicotine be a cost-effective way to prevent smoking uptake in adolescents? | AIMS: We used epidemiological modelling to assess whether nicotine vaccines would be a cost-effective way of preventing smoking uptake in adolescents.DESIGN, SETTING, PARTICIPANTS AND MEASUREMENTS: We built an epidemiological model using Australian data on age-specific smoking prevalence; smoking cessation and relapse ... | ['Adolescent', 'Australia', 'Cohort Studies', 'Cost-Benefit Analysis', 'Female', 'Humans', 'Male', 'Prevalence', 'Quality-Adjusted Life Years', 'Smoking', 'Smoking Prevention', 'Tobacco Use Disorder', 'Vaccination', 'Young Adult'] | 22,084,967 | [['M01.060.057'], ['Z01.639.100', 'Z01.678.100.373'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['N03.219.151.125'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.750', 'N01.224.935.597.750', 'N06.850.505.400.975.525.750', 'N06.850.520.308.985.525.750'], ['E... | ['Named Groups [M]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Squamous cell carcinoma antigen in patients with cutaneous disorders. | Serum levels of the tumor marker squamous cell carcinoma antigen (TA-4) were examined in patients with nonneoplastic dermatologic diseases. The majority of patients with significant disease had elevated levels of this antigen. The percentage of involved skin surface area correlated with serum squamous cell carcinoma an... | ['Acute Kidney Injury', 'Antigens, Neoplasm', 'Carcinoma, Squamous Cell', 'Creatinine', 'Dermatitis, Atopic', 'Diagnosis, Differential', 'Humans', 'Kidney Failure, Chronic', 'Psoriasis', 'Radioimmunoassay', 'Serpins', 'Skin Diseases', 'Skin Neoplasms'] | 2,319,025 | [['C12.777.419.780.050', 'C13.351.968.419.780.050'], ['D23.050.285'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['D03.383.129.308.207'], ['C16.320.850.210', 'C17.800.174.193', 'C17.800.815.193', 'C17.800.827.210', 'C20.543.480.343'], ['E01.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.777.419.780.... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Modeling Parkinson's disease genetics: altered function of the dopamine system in Adh4 knockout mice. | Class IV alcohol dehydrogenase (ADH4) efficiently reduces aldehydes produced during lipid peroxidation, and may thus serve to protect from toxic effects of aldehydes e.g. on neurons. We hypothesized that ADH4 dysfunction may increase risk for Parkinson's disease (PD) and previously reported association of an ADH4 allel... | ['3,4-Dihydroxyphenylacetic Acid', 'Alcohol Dehydrogenase', 'Amphetamine', 'Analysis of Variance', 'Animals', 'Apomorphine', 'Chromatography, High Pressure Liquid', 'Disease Models, Animal', 'Dopamine', 'Dopamine Agents', 'Homovanillic Acid', 'Locomotion', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Mice, Knockout', 'Norepi... | 21,075,145 | [['D02.241.223.601.220'], ['D08.811.682.047.820.250'], ['D02.092.471.683.152.110'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['B01.050'], ['D03.132.098.038.290', 'D03.633.100.531.085.030.290', 'D03.633.400.095.290'], ['E05.196.181.400.300'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['D02... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Development of gas chromatography-flame ionization detection system with a single column and liquid nitrogen-free for measuring atmospheric C2-C12 hydrocarbons. | A liquid nitrogen-free GC-FID system equipped with a single column has been developed for measuring atmospheric C2-C12 hydrocarbons. The system is consisted of a cooling unit, a sampling unit and a separation unit. The cooling unit is used to meet the temperature needs of the sampling unit and the separation unit. The ... | ['Air Pollutants', 'Beijing', 'Chromatography, Gas', 'Flame Ionization', 'Hydrocarbons', 'Nitrogen', 'Temperature'] | 26,687,163 | [['D27.888.284.101'], ['Z01.252.474.164.225', 'Z01.433.114'], ['E05.196.181.349'], ['E05.196.181.349.390'], ['D02.455'], ['D01.268.604', 'D01.362.625'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.150.450', 'N06.230.300.100.725.710']] | ['Chemicals and Drugs [D]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
The effect of shear stress on the basolateral membrane potential of proximal convoluted tubule of the rat kidney. | As consequence of glomerular filtration the viscosity of blood flowing through the efferent arteriole increases. Recently, we found that shear stress modulates proximal bicarbonate reabsorption and nitric oxide (NO.) was the chemical mediator of this effect. In the present work, we found that agonists of NO. production... | ['Acetazolamide', 'Adenosine Triphosphatases', 'Animals', 'Bradykinin', 'Carbonic Anhydrase Inhibitors', 'Cation Transport Proteins', 'Electrophysiology', 'Endothelium, Vascular', 'Enzyme Inhibitors', 'Epithelial Cells', 'Glyburide', 'Kidney Tubules, Proximal', 'Male', 'Membrane Potentials', 'NG-Nitroarginine Methyl Es... | 17,219,192 | [['D02.886.675.867.060', 'D03.383.129.708.867.060'], ['D08.811.277.040.025'], ['B01.050'], ['D12.644.276.812.169', 'D12.644.400.090', 'D12.644.456.193', 'D12.776.467.812.169', 'D12.776.631.650.090', 'D23.469.050.375.110', 'D23.529.812.169'], ['D27.505.519.389.200'], ['D12.776.157.530.450.250', 'D12.776.543.585.450.250'... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Buccal mucosal graft in reconstructive urology: uses beyond urethral stricture. | The use of buccal mucosal grafts for the reconstruction of urethral strictures is an established procedure. Because of its robustness, the buccal mucosal graft could also potentially provide an alternative for other indications in reconstructive urology. We report here six consecutive patients who received a buccal muc... | ['Adult', 'Follow-Up Studies', 'Humans', 'Lichen Sclerosus et Atrophicus', 'Male', 'Middle Aged', 'Mouth Mucosa', 'Penis', 'Reconstructive Surgical Procedures', 'Treatment Outcome', 'Ureter', 'Urethral Stricture', 'Urologic Surgical Procedures, Male'] | 25,110,793 | [['M01.060.116'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C17.800.859.475.605'], ['M01.060.116.630'], ['A10.615.550.599', 'A14.549.512'], ['A05.360.444.492'], ['E04.680'], ['E01.789.800', 'N04.761.559.590.800', 'N05.71... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose). | Intrinsically disordered proteins can phase separate from the soluble intracellular space, and tend to aggregate under pathological conditions. The physiological functions and molecular triggers of liquid demixing by phase separation are not well understood. Here we show in vitro and in vivo that the nucleic acid-mimic... | ['Cell Line, Tumor', 'Cloning, Molecular', 'DNA Damage', 'Gene Expression Regulation', 'Humans', 'Poly Adenosine Diphosphate Ribose', 'Protein Conformation', 'Protein Structure, Tertiary', 'Proteins'] | 26,286,827 | [['A11.251.210.190', 'A11.251.860.180'], ['E05.393.220'], ['G05.200'], ['G05.308'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D09.408.620.569.070.125.600', 'D13.695.578.550.530', 'D13.695.827.708.070.125.600'], ['G02.111.570.820.709'], ['G02.111.570.820.709.610'], ['D12.776']] | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endocytosis of HERG is clathrin-independent and involves arf6. | The hERG potassium channel is critical for repolarisation of the cardiac action potential. Reduced expression of hERG at the plasma membrane, whether caused by hereditary mutations or drugs, results in long QT syndrome and increases the risk of ventricular arrhythmias. Thus, it is of fundamental importance to understan... | ['ADP-Ribosylation Factors', 'Animals', 'Cell Membrane', 'Cholesterol', 'Clathrin', 'Dynamins', 'ERG1 Potassium Channel', 'Endocytosis', 'Ether-A-Go-Go Potassium Channels', 'HeLa Cells', 'Heart Ventricles', 'Humans', 'Myocytes, Cardiac', 'Rats', 'Rats, Wistar'] | 24,392,021 | [['D08.811.277.040.330.300.400.100', 'D12.644.360.525.100', 'D12.776.157.325.515.100', 'D12.776.476.525.100'], ['B01.050'], ['A11.284.149'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['D12.776.543.990.200'], ['D08.811.277.040.330.200', 'D12.776.220.600.450.200', 'D12.776.543.990.400'], ... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cyclic AMP directly activates NasP, an N-acyl amino acid antibiotic biosynthetic enzyme cloned from an uncultured beta-proteobacterium. | The cyclic AMP (cAMP)-dependent biosynthesis of N-acylphenylalanine antibiotics by NasP, an environmental DNA-derived N-acyl amino acid synthase, is controlled by an NasP-associated cyclic nucleotide-binding domain and is independent of the global cAMP signal transducer, cAMP receptor protein. A 16S rRNA gene sequence ... | ['Anti-Bacterial Agents', 'Bacterial Proteins', 'Betaproteobacteria', 'Carbon-Nitrogen Ligases', 'Cyclic AMP', 'DNA, Bacterial', 'DNA, Ribosomal', 'Enzyme Activation', 'Molecular Sequence Data', 'RNA, Ribosomal, 16S', 'Sequence Analysis, DNA'] | 17,586,635 | [['D27.505.954.122.085'], ['D12.776.097'], ['B03.660.075'], ['D08.811.464.259'], ['D03.633.100.759.646.138.395', 'D13.695.462.200', 'D13.695.667.138.395', 'D13.695.827.068.395'], ['D13.444.308.212'], ['D13.444.308.475'], ['G02.111.263', 'G03.328'], ['L01.453.245.667'], ['D13.444.735.686.670'], ['E05.393.760.700']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Outcomes in the management of appendicitis and cholecystitis in the setting of a new acute care surgery service model: impact on timing and cost. | BACKGROUND: The acute care surgery model is a novel notion in the provision of emergency general surgery. To date, several studies have analyzed the effects on patient health outcomes and timeliness of care for nontrauma patients within the scope of acute general surgery and emergencies, but none have assessed the cost... | ['Abdomen, Acute', 'Adult', 'Appendectomy', 'Appendicitis', 'Chi-Square Distribution', 'Cholecystectomy', 'Cholecystitis, Acute', 'Cost-Benefit Analysis', 'Emergency Service, Hospital', 'Female', 'Hospital Costs', 'Humans', 'Length of Stay', 'Male', 'Middle Aged', 'Models, Organizational', 'Postoperative Complications'... | 22,863,794 | [['C23.888.592.612.054.200', 'C23.888.821.030.249'], ['M01.060.116'], ['E04.210.078'], ['C01.463.099', 'C06.405.205.099', 'C06.405.469.110.207'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['E04.210.120.172'], ['C06.130.564.263.500'], ['N03.219.151.125'], ['N02.278.216... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Change of the names Haloanaerobiales, Haloanaerobiaceae and Haloanaerobium to Halanaerobiales, Halanaerobiaceae and Halanaerobium, respectively, and further nomenclatural changes within the order Halanaerobiales. | A formal proposal is made to rename the order Haloanaerobiales as Halanaerobiales, the family Haloanaerobiaceae as Halanaerobiaceae, the genera Haloanaerobium and Haloanaerobacter as Halanaerobium and Halanaerobacter, respectively, and to change the specific epithets of Halanaerobium acetoethylicum, Halanaerobacter lac... | ['Bacteria, Anaerobic', 'Sodium Chloride', 'Terminology as Topic'] | 11,156,000 | [['B03.130'], ['D01.210.450.150.875', 'D01.857.650'], ['L01.559.598.400']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Information Science [L]'] | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Microwave and man: the direct and indirect hazards, and the precautions. | Microwave-radar is a form of electromagnetic energy with potential hazards to human health and safety. Its lethal and non-lethal harmful effects have been demonstrated in experimental animals. Lethal effects upon humans from exposure to microwave have not been proved. Alleged non-lethal effects have been limited primar... | ['Diathermy', 'Environmental Health', 'Fires', 'Humans', 'Microwaves', 'Pacemaker, Artificial', 'Radiation Effects', 'Radiation Protection'] | 5,039,801 | [['E02.565.280'], ['H02.229'], ['N06.230.216'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.358.500.505.810.500', 'G01.750.250.810.500', 'G01.750.770.721.500'], ['E07.305.250.750'], ['G01.750.745', 'N06.850.810.300'], ['N06.850.810.425']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Galactosylsphingosine inhibition of the broad-specificity cytosolic beta-glucosidase of human liver. | Glucosylsphingosine is a potent inhibitor of lysosomal glucocerebrosidase and the broad-specificity, cytosolic beta-glucosidase of human liver. In the present study, it was demonstrated that the broad-specificity beta-glucosidase was also inhibited by galactosylsphingosine. The inhibition was observed when the enzyme w... | ['Amino Acids', 'Binding Sites', 'Chemical Phenomena', 'Chemistry', 'Chromatography', 'Cytosol', 'Glucosidases', 'Humans', 'Kinetics', 'Liver', 'Psychosine', 'Sphingosine', 'Substrate Specificity', 'beta-Glucosidase'] | 3,918,500 | [['D12.125'], ['G02.111.570.120'], ['G02'], ['H01.181'], ['E05.196.181'], ['A11.284.430.214.200', 'A11.284.430.429.200', 'A11.284.835.450.200'], ['D08.811.277.450.420'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.374.661', 'G02.111.490'], ['A03.620'], ['D02.033.100.700.700', 'D02.092.063.700.700', 'D09.400.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Synthesis and in vitro-anticancer and antimicrobial evaluation of some novel quinoxalines derived from 3-phenylquinoxaline-2(1H)-thione. | Two novel series derived from 3-phenylquinoxaline-2(1H)-thione 2 and 2-(hydrazinocarbonylmethylthio)-3-phenylquinoxaline 6 have been synthesized. Eight out of twenty six new compounds were selected at the National Cancer Institute for evaluation of their in vitro-anticancer activity. Among them, compounds 3b, 3c, 4b, a... | ['Ampicillin', 'Anti-Infective Agents', 'Antifungal Agents', 'Antineoplastic Agents', 'Bacteria', 'Candida albicans', 'Cell Line, Tumor', 'Cell Proliferation', 'Clotrimazole', 'Dose-Response Relationship, Drug', 'Drug Screening Assays, Antitumor', 'Growth Inhibitors', 'Humans', 'Microbial Sensitivity Tests', 'Molecular... | 16,881,038 | [['D02.065.589.099.750.750.050', 'D02.886.108.750.750.050', 'D03.633.100.300.750.750.050'], ['D27.505.954.122'], ['D27.505.954.122.136'], ['D27.505.954.248'], ['B03'], ['B01.300.107.795.095.326', 'B01.300.381.147.326', 'B01.300.930.176.326'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.161.750', 'G07.345.249.410.750'... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Characterization of a multi-leaf collimator system. | Commissioning measurements for a multi-leaf collimator installed on a dual energy accelerator with 6 and 15 MV photons are described. Detailed dosimetric characterization of the multi-leaf collimator is a requirement for modeling the collimator with treatment planning software. Measurements include a determination of t... | ['Equipment Design', 'Evaluation Studies as Topic', 'Humans', 'Radiotherapy Dosage', 'Radiotherapy Planning, Computer-Assisted', 'Radiotherapy, High-Energy'] | 8,420,867 | [['E05.320'], ['E05.337', 'N05.715.360.335'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.815.639'], ['E02.950.825', 'L01.313.500.750.100.710.600.608'], ['E02.815.722']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Structural constraints affect the metabolism of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) by carboxylesterases. | 7-Ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin [CPT-11 (irinotecan)] is a water-soluble camptothecin-derived prodrug that is activated by esterases to yield the potent topoisomerase I poison SN-38. We identified a rabbit liver carboxylesterase (CE) that was very efficient at CPT-11 metabolism; howeve... | ['Amino Acid Sequence', 'Animals', 'Antineoplastic Agents, Phytogenic', 'COS Cells', 'Camptothecin', 'Carboxylic Ester Hydrolases', 'Catalysis', 'Esterases', 'Esters', 'Humans', 'Irinotecan', 'Kinetics', 'Models, Molecular', 'Molecular Sequence Data', 'Prodrugs', 'Protein Conformation', 'Rabbits', 'Recombinant Fusion P... | 11,455,023 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D27.505.954.248.179'], ['A11.251.210.172.500', 'A11.329.228.220'], ['D03.132.151'], ['D08.811.277.352.100'], ['G02.130'], ['D08.811.277.352'], ['D02.241.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.132.151.425'], ['G01.374.661', 'G02.111.490']... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Growing Escherichia coli mutants deficient in riboflavin biosynthesis with non-limiting riboflavin results in sensitization to inactivation by broad-spectrum near-ultraviolet light (320-400 nm). | Two mutants of Escherichia coli unable to synthesize riboflavin were grown with limiting (2 micrograms ml-1) and non-limiting (10 micrograms ml-1) concentrations of riboflavin. These riboflavin auxotrophs when grown to exponential phase with non-limiting riboflavin are more sensitive to broad spectrum near-ultraviolet ... | ['Escherichia coli', 'Mutation', 'Riboflavin', 'Ultraviolet Rays'] | 2,089,438 | [['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['G05.365.590'], ['D03.633.100.733.315.650', 'D03.633.300.507.650', 'D08.211.474.650', 'D23.767.405.650'], ['G01.358.500.505.650.891', 'G01.590.540.891', 'G01.750.250.650.891', 'G01.750.750.659', 'G01.750.770.578.891', 'G16.500.275.063.725.525.600', 'G16.500.750.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Synchrony in mother-infant interactions. | A measure of mother-infant synchrony was developed and used to compare the interactions of mothers with preterm and mothers with full-term infants. Each mother-infant dyad was observed during a standard bottle-feeding session on 3 separate occasions: once prior to hospital discharge and 1 and 3 months after discharge. ... | ['Child Abuse', 'Female', 'Humans', 'Infant', 'Male', 'Mother-Child Relations', 'Social Environment'] | 498,860 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Stretch-Induced Interdigitation of a Phospholipid/Cholesterol Bilayer. | The interdigitated gel (LâI) phase is one of the membrane phases of phospholipid molecules in which the hydrophobic tails of the phospholipid molecules penetrate the opposite leaflet of the bilayer. Recent molecular dynamics (MD) simulations have shown that interdigitation can take place as a phase transition from the ... | ['1,2-Dipalmitoylphosphatidylcholine', 'Cholesterol', 'Lipid Bilayers', 'Molecular Dynamics Simulation'] | 29,419,298 | [['D10.570.755.375.760.400.800.224'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['D10.570.510', 'J01.637.087.500.510'], ['E05.599.595.500', 'G02.111.570.895', 'L01.224.160.500']] | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Information Science [L]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Analysis of the slow germination of multiple individual superdormant Bacillus subtilis spores using multifocus Raman microspectroscopy and differential interference contrast microscopy. | AIM: To analyse the dynamic germination of hundreds of individual superdormant (SD) Bacillus subtilis spores.METHODS AND RESULTS: Germination of hundreds of individual SD B. subtilis spores with various germinants and under different conditions was followed by multifocus Raman microspectroscopy and differential interfe... | ['Bacillus subtilis', 'Microscopy, Interference', 'Picolinic Acids', 'Spectrum Analysis, Raman', 'Spores, Bacterial'] | 22,212,253 | [['B03.300.390.400.158.218.725', 'B03.353.500.100.218.725', 'B03.510.100.100.218.725', 'B03.510.415.400.158.218.725', 'B03.510.460.410.158.218.725'], ['E01.370.350.515.513', 'E05.490.630', 'E05.595.513'], ['D03.066.707', 'D03.383.725.705'], ['E05.196.822.860', 'E05.196.867.890'], ['A11.870.700', 'B05.775.700']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Regional differences in recipient waitlist time and pre- and post-transplant mortality after the 2006 United Network for Organ Sharing policy changes in the donor heart allocation algorithm. | OBJECTIVES: This study examined the impact of the United Network for Organ Sharing (UNOS) policy changes for regional differences in waitlist time and mortality before and after heart transplantation.BACKGROUND: The 2006 UNOS thoracic organ allocation policy change was implemented to allow for greater regional sharing ... | ['Algorithms', 'Female', 'Health Policy', 'Heart Failure', 'Heart Transplantation', 'Heart-Assist Devices', 'Humans', 'Male', 'Middle Aged', 'Postoperative Care', 'Preoperative Care', 'Resource Allocation', 'Tissue and Organ Procurement', 'United States', 'Waiting Lists'] | 24,720,925 | [['G17.035', 'L01.224.050'], ['I01.655.500.608.400', 'I01.880.604.825.608.400', 'N03.623.500.608.428'], ['C14.280.434'], ['E04.100.376.475', 'E04.928.220.390', 'E04.936.450.475'], ['E04.050.430', 'E07.695.300.300', 'E07.858.082.374.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E02.760.7... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
The complete mitochondrial genome of the Fossorochromis rostratus. | The Fossorochromis rostratus is a species of cichlid endemic to Lake Malawi in East Africa. In this study, we first reported the complete mitochondrial genome of F. rostratus. The whole mitochondrial genome is 16 581 bp in length, which contains 13 protein-coding genes, 22 transfer RNA genes, and two ribosomal RNA gene... | ['Animals', 'Base Composition', 'Base Sequence', 'Cichlids', 'Conserved Sequence', 'DNA, Mitochondrial', 'Gene Order', 'Genes, Mitochondrial', 'Genome', 'Genome, Mitochondrial', 'Phylogeny', 'Sequence Analysis, DNA'] | 26,369,669 | [['B01.050'], ['G02.111.080'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['B01.050.150.900.493.602.200'], ['G02.111.570.580'], ['D13.444.308.283.225'], ['G05.340'], ['G05.360.340.024.340.365', 'G05.420.275.500'], ['G05.360.340'], ['G05.360.340.360'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['E05.393... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
[A bleeding jejunal schwannoma. The complications of a rare neoplasm of the small intestine]. | The authors report a rare case of jejunal Schwannoma which appeared as hematemesis and melaena. No preoperative test, even selective angiography, enabled a correct clinical diagnosis to be made. Only after explorative laparotomy and careful palpation of the small intestine was the bleeding lesion located. Resection and... | ['Adult', 'Gastrointestinal Hemorrhage', 'Hematemesis', 'Humans', 'Jejunal Neoplasms', 'Jejunum', 'Male', 'Melena', 'Neurilemmoma', 'Rectum'] | 8,327,184 | [['M01.060.116'], ['C06.405.227', 'C23.550.414.788'], ['C06.405.227.400', 'C23.550.414.788.400', 'C23.888.821.937.019'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.274.476.411.523', 'C06.301.371.411.523', 'C06.405.249.411.523', 'C06.405.469.491.523', 'C06.405.469.600.523'], ['A03.556.124.684.500', 'A03.... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Extent to which pulmonary vascular responses to PCO2 and PO2 play a functional role within the healthy human lung. | Regional blood flow in the lung is known to be influenced by the alveolar PCO2 and alveolar PO2. For the healthy lung, the extent to which this influence is of functional importance in limiting heterogeneity in alveolar gas composition by matching regional perfusion (q) to regional ventilation (v) remains unclear. To a... | ['Adaptation, Physiological', 'Adult', 'Carbon Dioxide', 'Echocardiography, Doppler', 'Female', 'Heart Rate', 'Humans', 'Hypercapnia', 'Hyperventilation', 'Hypocapnia', 'Lung', 'Male', 'Models, Cardiovascular', 'Oxygen', 'Partial Pressure', 'Pulmonary Circulation', 'Reference Values', 'Regional Blood Flow', 'Stroke Vol... | 20,185,627 | [['G07.025', 'G16.012.500'], ['M01.060.116'], ['D01.200.200', 'D01.362.150', 'D01.650.550.200'], ['E01.370.350.130.750.220', 'E01.370.350.850.220.220', 'E01.370.350.850.850.220', 'E01.370.370.380.220.220'], ['E01.370.600.875.500', 'G09.330.380.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.888.852.544'],... | ['Phenomena and Processes [G]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Marinobufagenin inhibits glioma growth through sodium pump á1 subunit and ERK signaling-mediated mitochondrial apoptotic pathway. | Malignant glioma is one of the most challenging central nervous system diseases to treat and has high rates of recurrence and mortality. Current therapies often fail to control tumor progression or improve patient survival. Marinobufagenin (MBG) is an endogenous mammalian cardiotonic steroid involved in sodium pump inh... | ['Animals', 'Antineoplastic Agents', 'Apoptosis', 'Bufanolides', 'Cell Cycle', 'Cell Line, Tumor', 'Cell Movement', 'Cell Proliferation', 'Cell Survival', 'Cytochromes c', 'Extracellular Signal-Regulated MAP Kinases', 'Glioma', 'Humans', 'Membrane Potential, Mitochondrial', 'Mice', 'Mice, Inbred BALB C', 'Mice, Nude', ... | 29,582,577 | [['B01.050'], ['D27.505.954.248'], ['G04.146.954.035'], ['D04.210.500.155.580.064'], ['G04.144'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.198', 'G07.568.500.180'], ['G04.161.750', 'G07.345.249.410.750'], ['G04.346'], ['D08.244.286.100', 'D12.776.422.220.286.100'], ['D08.811.913.696.620.682.700.567.249', 'D12.644.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Archives of Medical Research: an historical and subject coverage overview. | A bibliometric study about the subject content of the articles published in the Mexican scientific journal Archives of Medical Research is reported. The journal, published by the Mexican Institute of Social Security (IMSS), is comprised of 100 regular issues and 12 special supplements giving a total amount of 1,424 rep... | ['Animals', 'Bibliometrics', 'History, 20th Century', 'Mexico', 'Periodicals as Topic'] | 8,845,632 | [['B01.050'], ['L01.178.682.099.325', 'L01.453.183.291'], ['K01.400.504.968'], ['Z01.107.567.589'], ['L01.178.682.829.678']] | ['Organisms [B]', 'Information Science [L]', 'Humanities [K]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 |
Anthelmintic activity of the crude extracts, fractions, and osthole from Radix angelicae pubescentis against Dactylogyrus intermedius in goldfish (Carassius auratus) in vivo. | A bioassay-guided fractionation was performed to evaluate the anthelmintic activity of the crude extract fractions and osthole from Radix angelicae pubescentis against Dactylogyrus intermedius in goldfish (Carassius auratus) in vivo. Among four extracts (petroleum ether, ethyl acetate, acetone, and ethanol), only ethan... | ['Angelica', 'Animals', 'Anthelmintics', 'Chemical Fractionation', 'Complex Mixtures', 'Goldfish', 'Plant Extracts', 'Plant Roots', 'Platyhelminths', 'Survival Analysis', 'Trematode Infections'] | 20,878,184 | [['B01.650.940.800.575.912.250.075.088'], ['B01.050'], ['D27.505.954.122.250.075'], ['E05.196.155'], ['D20'], ['B01.050.150.900.493.200.244.248.480'], ['D20.215.784.500', 'D26.667'], ['A18.400'], ['B01.050.500.500.736'], ['E05.318.740.998', 'N05.715.360.750.795', 'N06.850.520.830.998'], ['C01.610.335.865']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Health Care [N]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Oncovascular compartmental resection for retroperitoneal soft tissue sarcoma with vascular involvement. | OBJECTIVE: This study analyzed the outcomes of a series of consecutive patients diagnosed with a retroperitoneal soft tissue sarcoma (RSTS) with vascular involvement and who underwent a multidisciplinary operation.METHODS: Between 2000 and 2013, 126 patients were referred for oncovascular surgery in our institution. Am... | ['Adult', 'Aged', 'Aged, 80 and over', 'Arteries', 'Blood Vessel Prosthesis', 'Blood Vessel Prosthesis Implantation', 'Computed Tomography Angiography', 'Disease-Free Survival', 'Female', 'France', 'Humans', 'Length of Stay', 'Male', 'Middle Aged', 'Neoplasm Invasiveness', 'Neoplasm Recurrence, Local', 'Retroperitoneal... | 27,374,069 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['A07.015.114'], ['E07.695.110'], ['E04.100.814.868.500', 'E04.650.200'], ['E01.370.350.350.810.335', 'E01.370.350.567.250', 'E01.370.350.600.350.700.810.335', 'E01.370.350.700.700.810.335', 'E01.370.350.700.810.810.568', 'E01.370.350.825.810.810.499'], ['... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
L-pipecolic acid metabolism in human liver: L-alpha-aminoadipate delta-semialdehyde oxidoreductase. | A soluble enzyme that catalyzes the oxidation of L-alpha-aminoadipate delta-semialdehyde to L-alpha-aminoadipic acid in the presence of NAD+ has been isolated and characterized from human liver. This enzyme L-alpha-aminoadipic delta-semialdehyde oxidoreductase has been found to be localized in the cytosol using subcell... | ['2-Aminoadipic Acid', 'Adult', 'Aldehyde Oxidoreductases', 'Coenzymes', 'Humans', 'Hydrogen-Ion Concentration', 'Kinetics', 'L-Aminoadipate-Semialdehyde Dehydrogenase', 'Liver', 'Microbodies', 'Pipecolic Acids', 'Povidone', 'Pseudomonas', 'Silicon Dioxide', 'Substrate Specificity'] | 2,160,277 | [['D02.241.081.337.052.075', 'D12.125.119.075'], ['M01.060.116'], ['D08.811.682.657.163'], ['D08.211'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.300'], ['G01.374.661', 'G02.111.490'], ['D08.811.682.657.163.796'], ['A03.620'], ['A11.284.430.214.190.500.585', 'A11.284.430.214.190.875.190.190.755'], ['D03.06... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 |
Comparison of conventional oral cyclosporine and cyclosporine microemulsion formulations in children with a liver transplant. | We studied 22 children (mean age: 8.42 years, range: 1.9-15.6 years) with a liver transplant to compare the pharmacokinetics of oral cyclosporine (CsA) microemulsion to the conventional formulation. The CsA treatment (mean dose: 5.9 mg/kg/day, range: 3.0-11.7 mg/kg/day) was converted 1:1 on a milligram-to-milligram bas... | ['Administration, Oral', 'Adolescent', 'Child', 'Child, Preschool', 'Cyclosporine', 'Emulsions', 'Humans', 'Immunosuppression', 'Immunosuppressive Agents', 'Infant', 'Liver Transplantation', 'Metabolic Clearance Rate'] | 8,693,548 | [['E02.319.267.100'], ['M01.060.057'], ['M01.060.406'], ['M01.060.406.448'], ['D04.345.566.235.300', 'D12.644.641.235.300'], ['D20.280.260', 'D26.255.165.260'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.095.465.425.450', 'E05.478.610'], ['D27.505.696.477.656'], ['M01.060.703'], ['E02.095.147.725.490', 'E04... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Monitoring trabecular bone microdamage using a dynamic acousto-elastic testing method. | Dynamic acousto-elastic testing (DAET) is based on the coupling of a low-frequency (LF) acoustic wave and high-frequency ultrasound (US) pulses (probing wave). It was developed to measure US viscoelastic and dissipative non-linearity in trabecular bone. It is well known that this complex biphasic medium contains microd... | ['Biomechanical Phenomena', 'Calcaneus', 'Elasticity Imaging Techniques', 'Histological Techniques', 'Humans', 'Microscopy, Confocal', 'Nonlinear Dynamics', 'Viscosity'] | 21,485,329 | [['G01.154.090', 'G01.374.089'], ['A02.835.232.043.300.710.300'], ['E01.370.350.850.270'], ['E01.370.225.750', 'E05.200.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.515.395', 'E05.595.395'], ['E05.599.850', 'H01.548.675'], ['G02.930']] | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
The rice field cyanobacteria Anabaena azotica and Anabaena sp. CH1 express vanadium-dependent nitrogenase. | Anabaena azotica FACHB-118 and Anabaena sp. CH1, heterocystous cyanobacteria isolated from Chinese and Taiwanese rice fields, expressed vanadium-containing nitrogenase when under molybdenum deficiency. This is the second direct observation of an alternative nitrogenase in cyanobacteria. The vanadium nitrogenase-specifi... | ['Amino Acid Sequence', 'Anabaena', 'Bacterial Proteins', 'Culture Media', 'Genes, Bacterial', 'Molecular Sequence Data', 'Molybdenum', 'Nitrogenase', 'Oryza', 'Phylogeny', 'Sequence Alignment'] | 16,924,483 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B03.280.100', 'B03.440.475.100.100', 'B03.585.051'], ['D12.776.097'], ['D27.720.470.305', 'E07.206'], ['G05.360.340.024.340.364.249', 'G05.360.340.358.024.249', 'G05.360.340.358.207.249'], ['L01.453.245.667'], ['D01.268.556.555', 'D01.268.956.500', 'D01.552.544.555'], ['D0... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Dietary interviewing by computer. An experimental approach to counseling. | A computer-based dietary counseling system was tested by sixty-four volunteers from the Boston area. Most of the patients seemed to benefit from their interaction with the computer, and the two participating nutritionists frequently found that the program was useful as an antecedent to their own one-to-one sessions wit... | ['Adult', 'Computers', 'Counseling', 'Dietetics', 'Evaluation Studies as Topic', 'Feeding Behavior', 'Female', 'Food Preferences', 'Humans', 'Male', 'Middle Aged', 'Nutritional Physiological Phenomena', 'Obesity', 'Patient Compliance'] | 977,878 | [['M01.060.116'], ['L01.224.230.260'], ['F02.784.176', 'F04.408.413', 'N02.421.143.303', 'N02.421.461.363'], ['H02.533.290'], ['E05.337', 'N05.715.360.335'], ['F01.145.113.547', 'F01.145.407', 'G07.203.650.353'], ['F01.145.407.516', 'G07.203.650.353.516'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.... | ['Named Groups [M]', 'Information Science [L]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 |
Spinal myxopapillary ependymoma with Down syndrome: exploring an unusual association. | SUMMARY: In patients with Down syndrome, cancers like leukemia and testicular tumors are frequent, but association with central nervous system tumors is rare. Only 1 case of ependymoma has been observed as an incidental autopsy finding in a 19-week-old female fetus. We herein report the second case of ependymoma and th... | ['Adolescent', 'Combined Modality Therapy', 'Down Syndrome', 'Ependymoma', 'Female', 'Humans', 'Karyotyping', 'Remission Induction', 'Spinal Cord Neoplasms'] | 20,051,776 | [['M01.060.057'], ['E02.186'], ['C10.597.606.360.220', 'C16.131.077.327', 'C16.131.260.260', 'C16.320.180.260'], ['C04.557.465.625.600.380.290', 'C04.557.470.670.380.290', 'C04.557.580.625.600.380.290'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.385.315', 'E05.200.500.385.315', 'E05.242.385.315... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[The role of computerized tomography in the diagnosis of brain lesions in patients with epileptic attacks]. | Computer-aided tomography was used to examine 449 patients suffering from epileptic attacks. In patients with setting in epileptic attacks, computer-aided tomography has been shown to play a preventive role, contributing to early diagnosis of cerebral diseases, primarily tumors. Specification of the character of cerebr... | ['Adolescent', 'Adult', 'Age Factors', 'Brain Neoplasms', 'Cerebrovascular Disorders', 'Child', 'Epilepsies, Partial', 'Female', 'Humans', 'Male', 'Middle Aged', 'Tomography, X-Ray Computed'] | 2,171,266 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['C10.228.140.300', 'C14.907.253'], ['M01.060.406'], ['C10.228.140.490.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.370.350.350.810', 'E01.370.3... | ['Named Groups [M]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Terminally Ill Cancer Patients' Distinct Symptom-Functional Patterns/States Are Differentially Associated with Their Accurate Prognostic Awareness in the Last Six Months of Life. | Background: Terminally ill cancer patients' worsening symptom distress and functional impairment may signal disease deterioration, thus facilitating their accurate prognostic awareness (PA). However, the joint roles played by symptom distress and functional impairment in association with cancer patients' accurate PA re... | ['Attitude to Death', 'Awareness', 'Disease Progression', 'Female', 'Humans', 'Longitudinal Studies', 'Male', 'Neoplasms', 'Prognosis', 'Symptom Flare Up', 'Taiwan', 'Terminally Ill'] | 30,888,907 | [['F01.100.125', 'N05.300.125'], ['F02.463.188.150'], ['C23.550.291.656'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.500.750.500', 'N05.715.360.330.500.750.500', 'N06.850.520.450.500.750.500'], ['C04'], ['E01.789'], ['C23.550.291.937.500'], ['Z01.252.474.872', 'Z01.639.850'], ['M01.873']] | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
The experience of pay for performance in English family practice: a qualitative study. | PURPOSE: We conducted an in-depth exploration of family physicians' and nurses' beliefs and concerns about changes to the family health care service as a result of the new pay-for-performance scheme in the United Kingdom (Quality and Outcomes Framework [QOF]).METHODS: Using a semistructured interview format, we intervi... | ['Adult', 'Attitude of Health Personnel', 'Consumer Behavior', 'England', 'Female', 'Health Care Reform', 'Humans', 'Male', 'Middle Aged', "Nurse's Role", 'Nursing Staff', 'Physician Incentive Plans', 'Physicians, Family', "Practice Patterns, Physicians'", 'Primary Health Care', 'Qualitative Research', 'Quality of Heal... | 18,474,885 | [['M01.060.116'], ['F01.100.050', 'N05.300.100'], ['F01.145.236'], ['Z01.542.363.300'], ['I01.655.500.608.400.285', 'I01.880.604.825.608.400.285', 'N03.349.285', 'N03.623.500.608.428.285', 'N04.590.374.285', 'N05.300.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['F01.829.316.616.625.450'... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
A prospective study of the efficacy of the physician order form for life-sustaining treatment. | OBJECTIVES: The Physician Orders for Life-Sustaining Treatment (POLST), a comprehensive, one-page order form, was developed to convey preferences for life-sustaining treatments during transfer from one care site to another. This study examined the extent to which the POLST form ensured that nursing home residents' wish... | ['Advance Care Planning', 'Advance Directive Adherence', 'Advance Directives', 'Aged', 'Aged, 80 and over', 'Female', 'Hospitalization', 'Humans', 'Life Support Care', 'Male', 'Nursing Homes', 'Oregon', 'Patient Transfer', 'Prospective Studies', 'Quality of Health Care', 'Records', 'Resuscitation Orders', 'Stress, Psyc... | 9,736,102 | [['N04.590.233.624.124'], ['N04.761.040', 'N05.715.360.317'], ['I01.880.604.583.020', 'N03.706.535.020', 'N04.590.233.624.124.050'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E02.760.400', 'N02.421.585.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.760.440', 'N02.421.585.440'], ['N02.278.825.610'],... | ['Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]', 'Information Science [L]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
Living-related liver transplantation for Wilson's disease. | Liver transplantation with liver grafts from deceased donors is the treatment of choice for patients suffering from Wilson's disease (WD) with end-stage liver disease. There are few reports, however, on the use of liver grafts from living-related donors for WD. Five (two pediatric and three adult recipients) underwent ... | ['Adolescent', 'Adult', 'Ceruloplasmin', 'Child', 'Copper', 'Female', 'Hepatolenticular Degeneration', 'Humans', 'Liver Cirrhosis', 'Liver Failure, Acute', 'Liver Transplantation', 'Living Donors', 'Male', 'Treatment Outcome'] | 16,008,592 | [['M01.060.057'], ['M01.060.116'], ['D08.811.682.226', 'D12.776.124.050.130', 'D12.776.124.790.106.214', 'D12.776.157.160', 'D12.776.377.715.085.214', 'D12.776.556.151'], ['M01.060.406'], ['D01.268.556.195', 'D01.268.956.170', 'D01.552.544.195'], ['C06.552.413', 'C10.228.140.079.493', 'C10.228.140.163.100.360', 'C10.22... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Enhancement of azo dye decolourization in a MFC-MEC coupled system. | Microbial fuel cells (MFCs) have shown the potential for azo dye decolourization. In this study, a MFC-MEC (microbial electrolysis cell) coupled system was established in order to enhance azo dye decolourization, and the influence of several key factors on reactor performance was evaluated. Moreover, a theoretical anal... | ['Acetates', 'Azo Compounds', 'Bioelectric Energy Sources', 'Color', 'Coloring Agents', 'Electricity', 'Electrodes', 'Electrolysis', 'Hydrogen-Ion Concentration'] | 26,702,516 | [['D02.241.081.018', 'D10.251.400.045'], ['D02.172'], ['E07.305.124.150'], ['G01.590.540.199'], ['D27.720.233'], ['G01.358.500.249'], ['E07.305.250'], ['E05.301.250'], ['G02.300']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Enhanced detection of receptor constitutive activity in the presence of regulators of G protein signaling: applications to the detection and analysis of inverse agonists and low-efficacy partial agonists. | Fusion proteins between the human 5-hydroxytryptamine (5-HT)(1A) receptor and either wild type or certain pertussis toxin-resistant forms of G(o1)alpha and G(i1)alpha display constitutive GTPase activity that can be inhibited by the inverse agonist spiperone. Addition of recombinant regulator of G protein signaling (RG... | ['Cells, Cultured', 'GTP-Binding Proteins', 'GTPase-Activating Proteins', 'Humans', 'Piperazines', 'Proteins', 'Pyridines', 'RGS Proteins', 'Receptors, Serotonin', 'Receptors, Serotonin, 5-HT1', 'Recombinant Fusion Proteins', 'Signal Transduction'] | 11,961,140 | [['A11.251'], ['D08.811.277.040.330.300', 'D12.776.157.325'], ['D12.644.360.325.150', 'D12.776.476.325.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.383.606'], ['D12.776'], ['D03.383.725'], ['D12.644.360.325.150.750', 'D12.776.476.325.150.750'], ['D12.776.543.750.670.800', 'D12.776.543.750.695.800', 'D1... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A new pollen-derived microcarrier for pantoprazole delivery. | Plant-derived carriers have emerged as promising materials for drug encapsulation. Especially, sporopollenin microcapsules extracted from diverse pollen species have been proved to be effective drug carriers due to their biocompatibility, homogeneity in size, resistance to harsh chemical conditions and high thermal sta... | ['2-Pyridinylmethylsulfinylbenzimidazoles', 'Corylus', 'Drug Carriers', 'Pantoprazole', 'Pollen'] | 27,987,792 | [['D02.886.640.074', 'D03.383.725.024', 'D03.633.100.103.034'], ['B01.650.940.800.575.912.250.859.750.200.875'], ['D26.255.260', 'E02.319.300.380'], ['D02.886.640.074.625', 'D03.383.725.024.625', 'D03.633.100.103.034.625'], ['A18.024.249.500.249.500']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Possible influence of tachykinins on body fluid homeostasis in the rat. | The effect on water intake, urine flow and vasopressin release of intracranial injections of substance P, physalaemin and eledoisin was studied in Wistar and Brattleboro, homozygous and heterozygous, rats. The tachykinins strongly inhibited water intake both in Wistar and in Brattleboro, homozygous and heterozygous, ra... | ['Animals', 'Arginine Vasopressin', 'Body Fluids', 'Diuresis', 'Dose-Response Relationship, Drug', 'Drinking', 'Electric Conductivity', 'Eledoisin', 'Homeostasis', 'Kinetics', 'Kinins', 'Physalaemin', 'Rats', 'Rats, Brattleboro', 'Rats, Inbred Strains', 'Substance P', 'Urine', 'Vasopressins'] | 6,085,638 | [['B01.050'], ['D06.472.699.631.692.781.100', 'D12.644.400.900.100', 'D12.644.456.925.100', 'D12.644.548.691.692.781.100', 'D12.776.631.650.937.100'], ['A12.207'], ['G08.852.179'], ['G07.690.773.875', 'G07.690.936.500'], ['G07.203.650.283.249', 'G10.261.330.249'], ['G01.358.500.249.277'], ['D12.644.276.812.900.354', 'D... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Unexpected diversity in populations of the many-celled magnetotactic prokaryote. | The many-celled magnetotactic prokaryote (MMP) is an uncultivated, highly motile aggregate of 10-30 cells containing numerous chains of greigite (Fe(3)S(4)) magnetosomes. It is unique to marine environments and is abundant in slightly sulfidic sediments of the Little Sippewissett salt marsh (Falmouth, MA). We sequenced... | ['Biodiversity', 'DNA, Ribosomal', 'Deltaproteobacteria', 'Ecosystem', 'Genes, rRNA', 'Geologic Sediments', 'In Situ Hybridization, Fluorescence', 'Iron', 'Magnetics', 'Polymerase Chain Reaction', 'RNA, Ribosomal, 16S', 'Sulfides', 'Wetlands'] | 17,227,425 | [['G16.500.275.157.049', 'N06.230.124.049'], ['D13.444.308.475'], ['B03.660.125'], ['G16.500.275.157', 'N06.230.124'], ['G05.360.340.024.340.645.750'], ['G01.311.330', 'G16.500.320'], ['E01.370.225.500.620.670.325.350', 'E01.370.225.750.600.670.325.350', 'E05.200.500.620.670.325.350', 'E05.200.750.600.670.325.350', 'E0... | ['Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Synthesis and biological activity of novel carbocyclic nucleosides. | The syntheses of several novel carbocyclic nucleosides which incorporate the cyclopentene moiety of neplanocin A will be presented. These include modified pyrimidine derivatives of the very potent antitumor agent cyclopentenyl cytosine and carbocyclic analogues of the ketohexose nucleosides psicofuranine and psicofuran... | ['Adenosine', 'Antibiotics, Antineoplastic', 'Antineoplastic Agents', 'Cytidine', 'Molecular Structure', 'Nucleosides'] | 2,101,908 | [['D03.633.100.759.590.138', 'D13.570.583.138', 'D13.570.800.096'], ['D27.505.954.248.106'], ['D27.505.954.248'], ['D03.383.742.680.245', 'D13.570.685.245', 'D13.570.800.286'], ['G02.111.570', 'G02.466'], ['D09.408.595', 'D13.570']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The putative plasma membrane Na(+)/H(+) antiporter SOS1 controls long-distance Na(+) transport in plants. | The salt tolerance locus SOS1 from Arabidopsis has been shown to encode a putative plasma membrane Na(+)/H(+) antiporter. In this study, we examined the tissue-specific pattern of gene expression as well as the Na(+) transport activity and subcellular localization of SOS1. When expressed in a yeast mutant deficient in ... | ['Arabidopsis', 'Biological Transport', 'Cloning, Molecular', 'Gene Expression Regulation, Plant', 'Genetic Complementation Test', 'Membrane Proteins', 'Mutation', 'Plant Leaves', 'Plant Roots', 'Plant Stems', 'Plants, Genetically Modified', 'Saccharomyces cerevisiae', 'Sodium', 'Sodium Chloride', 'Sodium-Hydrogen Exch... | 11,884,687 | [['B01.650.940.800.575.912.250.157.100'], ['G03.143'], ['E05.393.220'], ['G05.308.375'], ['E05.393.281.526'], ['D12.776.543'], ['G05.365.590'], ['A18.024.812'], ['A18.400'], ['A18.024.937'], ['B01.650.520', 'B05.620.600'], ['B01.300.107.795.785.800', 'B01.300.930.705.655'], ['D01.268.549.750', 'D01.268.557.650', 'D01.5... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Surgical anatomy and variations of the infraorbital nerve. | OBJECTIVES/HYPOTHESIS: To assess relevant variations in the anatomical course of the infraorbital nerve (ION). This understanding may reduce the risk of surgical injury.METHODS: A total of 100 consecutive computed-tomography sinus studies obtained in a tertiary referral center were reviewed, and measurements were made ... | ['Anatomic Variation', 'Female', 'Humans', 'Intraoperative Complications', 'Male', 'Maxillary Nerve', 'Tomography, X-Ray Computed'] | 25,992,806 | [['G07.049', 'G16.117.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.505'], ['A08.800.800.120.760.550'], ['E01.370.350.350.810', 'E01.370.350.600.350.700.810', 'E01.370.350.700.700.810', 'E01.370.350.700.810.810', 'E01.370.350.825.810.810']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A sandwich immunoassay to quantify low levels of turbot (Scophthalmus maximus) immunoglobulins. | We have developed an enzyme-linked immunosorbent assay for the quantification of turbot (Scophthalmus maximus) immunoglobulin (Ig). The capture antibody is a rabbit polyclonal antiserum to turbot Ig, and the detector antibody a monoclonal antibody (UR3) to the turbot Ig heavy chain. Both antibodies bind nearly 100% of ... | ['Animals', 'Antibodies, Monoclonal', 'Body Weight', 'Chromatography, Gel', 'Enzyme-Linked Immunosorbent Assay', 'Flatfishes', 'Fluorescent Antibody Technique', 'Immunoglobulins', 'Mice', 'Mice, Inbred BALB C', 'Precipitin Tests', 'Rabbits', 'Reproducibility of Results', 'Sensitivity and Specificity'] | 7,604,533 | [['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['E05.196.181.400.250'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170',... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
A delivery system for olfactory stimuli. | This paper describes the design of a new method for controlling and administering olfactory stimuli--namely, the hood system. The hood system involves a stream of vaporized odor (at known concentrations) mixed with odorless air and pumped (at a constant flow rate) into an oxygen therapy hood. It is designed to be used ... | ['Aromatherapy', 'Humans', 'Nebulizers and Vaporizers', 'Odorants', 'Smell'] | 10,633,983 | [['E02.190.525.061', 'E02.190.755.100', 'E02.190.888.061', 'F04.754.035'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E07.605'], ['G16.500.275.640', 'N06.230.480'], ['F02.830.816.643', 'G11.561.790.643']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
The Na+/I- symporter mediates iodide uptake in breast cancer metastases and can be selectively down-regulated in the thyroid. | PURPOSE: The Na(+)/I(-) symporter (NIS) is a key plasma membrane protein that mediates active iodide (I(-)) transport in the thyroid, lactating breast, and other tissues. Functional NIS expression in thyroid cancer accounts for the longstanding success of radioactive iodide ((131)I) ablation of metastases after thyroid... | ['Breast Neoplasms', 'Down-Regulation', 'Female', 'Humans', 'Immunohistochemistry', 'Iodides', 'Neoplasm Metastasis', 'Neoplasms', 'Radiometry', 'Radionuclide Imaging', 'Symporters', 'Thyroid Gland', 'Thyroid Neoplasms', 'Time Factors', 'Triiodothyronine'] | 15,240,514 | [['C04.588.180', 'C17.800.090.500'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512', 'H01.158.201.344.512', 'H01.158.201.486.... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Brain allopregnanolone induces marked scratching behaviour in diet-induced atopic dermatitis mouse model. | Allopregnanolone (ALLO) is a neurosteroid produced in the brain, but so far, no study has explored its link with itching. Herein, we used a diet-induced atopic dermatitis mouse model to examine whether exogenously administered and endogenously produced ALLO contribute to inducing scratching. Systemic administration of ... | ['Animals', 'Behavior, Animal', 'Brain', 'Dermatitis, Atopic', 'Diet', 'Disease Models, Animal', 'Eczema', 'Grooming', 'Male', 'Mice', 'Pregnanolone', 'Pruritus'] | 30,787,375 | [['B01.050'], ['F01.145.113'], ['A08.186.211'], ['C16.320.850.210', 'C17.800.174.193', 'C17.800.815.193', 'C17.800.827.210', 'C20.543.480.343'], ['G07.203.650.240'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['C17.800.174.620', 'C17.800.815.620'], ['F01.145.113.111.453'], ['B01.050.150.900.649.313.992.635.505.500'... | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Comprehension of human pointing gestures in horses (Equus caballus). | Twenty domestic horses (Equus caballus) were tested for their ability to rely on different human gesticular cues in a two-way object choice task. An experimenter hid food under one of two bowls and after baiting, indicated the location of the food to the subjects by using one of four different cues. Horses could locate... | ['Analysis of Variance', 'Animal Communication', 'Animals', 'Association Learning', 'Attention', 'Choice Behavior', 'Comprehension', 'Concept Formation', 'Discrimination Learning', 'Female', 'Gestures', 'Horses', 'Humans', 'Male', 'Recognition, Psychology', 'Social Environment', 'Socialization'] | 18,247,069 | [['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['F01.145.113.055'], ['B01.050'], ['F02.463.425.069.296'], ['F02.830.104.214'], ['F02.463.785.373.346'], ['F02.463.188.357'], ['F02.463.785.233'], ['F02.463.425.280'], ['F01.145.209.530.538.445'], ['B01.050.150.900.649.313.984.235.472'], ['B01.050.150.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Ampicillin/penicillin-binding protein interactions as a model drug-target system to optimize affinity pull-down and mass spectrometric strategies for target and pathway identification. | The identification and validation of the targets of active compounds identified in cell-based assays is an important step in preclinical drug development. New analytical approaches that combine drug affinity pull-down assays with mass spectrometry (MS) could lead to the identification of new targets and druggable pathw... | ['Ampicillin', 'Drug Delivery Systems', 'Mass Spectrometry', 'Microspheres', 'Penicillin-Binding Proteins', 'Sarcosine', 'Sepharose'] | 15,761,956 | [['D02.065.589.099.750.750.050', 'D02.886.108.750.750.050', 'D03.633.100.300.750.750.050'], ['E02.319.300'], ['E05.196.566'], ['E07.565'], ['D08.811.710', 'D12.776.097.545'], ['D12.125.481.700.374'], ['D09.698.813']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
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