Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Pharmacological Inhibition of Toll-Like Receptor-4 Signaling by TAK242 Prevents and Induces Regression of Experimental Organ Fibrosis. | Systemic sclerosis (SSc) is a poorly understood heterogeneous condition with progressive multi-organ fibrosis. Recent genetic and genomic evidence suggest a pathogenic role for dysregulated innate immunity and toll-like receptor (TLR) activity in SSc. Levels of both TLR4, as well as certain endogenous TLR ligands, are ... | ['Animals', 'Bleomycin', 'Cells, Cultured', 'Disease Models, Animal', 'Female', 'Fibroblasts', 'Fibrosis', 'Humans', 'Mice', 'Mice, Inbred C3H', 'Mice, Transgenic', 'Mutation', 'Pulmonary Fibrosis', 'Scleroderma, Systemic', 'Signal Transduction', 'Skin', 'Sulfonamides', 'Toll-Like Receptor 4'] | 30,405,628 | [['B01.050'], ['D09.400.420.110', 'D12.644.233.110'], ['A11.251'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['A11.329.228'], ['C23.550.355'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.388', 'B01.050.150.900.649.313.992.635.505.500.400.3... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Conformational stability of heme proteins in vacuo. | The function and conformational stability of myoglobin were studied in vacuo by using an electrospray mass spectrometer. The electrospray technique gently transfers protein molecules from the solution phase to the gas phase, and solvent-free protein ions are produced in the mass spectrometer. Horse myoglobin was dissol... | ['Animals', 'Apoproteins', 'Gas Chromatography-Mass Spectrometry', 'Horses', 'Metmyoglobin', 'Myoglobin', 'Protein Conformation', 'Protein Denaturation', 'Protein Folding', 'Vacuum'] | 8,068,649 | [['B01.050'], ['D12.776.070'], ['E05.196.181.349.500', 'E05.196.566.500'], ['B01.050.150.900.649.313.984.235.472'], ['D12.776.422.316.940.500'], ['D12.776.210.500.588', 'D12.776.422.316.940'], ['G02.111.570.820.709'], ['G01.154.651.750.500', 'G02.111.688.750.500'], ['G01.154.651', 'G02.111.688'], ['G01.374.715.902', 'G... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Factors determining survival after ruptured aortic aneurysm: the hospital, the surgeon, and the patient. | The 10-year experience of a single community was reviewed and a multivariate analysis was performed to determine the relative importance of clinical and environmental factors in mortality after ruptured abdominal aortic aneurysm resection. Ruptured aneurysms were repaired in 243 patients in six area hospitals (one univ... | ['Aged', 'Aged, 80 and over', 'Aortic Rupture', 'Female', 'Hematocrit', 'Hemodynamics', 'Hospitals', 'Humans', 'Male', 'Middle Aged', 'Multivariate Analysis', 'Postoperative Complications', 'Prognosis', 'Risk Factors', 'Survival Rate', 'Vascular Surgical Procedures'] | 2,325,210 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['C14.907.055.185.125', 'C14.907.055.239.175', 'C14.907.109.139.175', 'C26.761.125'], ['E01.370.225.625.400', 'E05.200.625.400', 'G09.188.370.374'], ['G09.330.380'], ['N02.278.421'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.740.150.50... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
TGGCA protein is present in erythroid nuclei and binds within the nuclease-hypersensitive sites 5' of the chicken beta H- and beta A-globin genes. | The developmentally regulated 5'-flanking DNase-I-hypersensitive site of the chicken beta H-globin gene in nuclei contains a subregion which is resistant to DNase I and which disappears when nuclei are extracted with 0.3 M NaCl, suggesting that there are salt-extractable proteins bound to sequences within this region. ... | ['Animals', 'Base Sequence', 'Blotting, Southern', 'CCAAT-Enhancer-Binding Proteins', 'Cell Nucleus', 'Chickens', 'Chromatin', 'DNA', 'DNA-Binding Proteins', 'Deoxyribonuclease I', 'Erythrocytes', 'Genes', 'Globins', 'Molecular Sequence Data', 'NFI Transcription Factors', 'Nuclear Proteins', 'Plasmids', 'Protein Bindin... | 3,197,715 | [['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.196.401.114', 'E05.301.300.087', 'E05.601.150'], ['D12.776.260.108.124', 'D12.776.660.167', 'D12.776.930.127.124'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['A11.284... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
The use of allografts in ligamentous reconstructions of the knee. | Our continuing experience with allografts has led us to the firm conclusion that there is a clear place for allografts in the ligamentous reconstruction of the unstable knee. Clearly, issues such as cost and availability will limit allograft usage, however concerns regarding inferior clinical results should not. Our ex... | ['Achilles Tendon', 'Arthroplasty', 'Bone Transplantation', 'Humans', 'Knee Joint', 'Ligaments, Articular', 'Tendons', 'Transplantation, Homologous'] | 11,436,432 | [['A02.880.176'], ['E04.555.110', 'E04.680.101'], ['E02.095.147.725.052', 'E04.555.130', 'E04.936.580.052'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.583.475'], ['A02.513.514', 'A02.835.583.512', 'A10.165.669.514'], ['A02.880'], ['E04.936.864']] | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Familiarity affects other-regarding preferences in pet dogs. | Other-regarding preferences are considered to be the foundation of human cooperation. However, the evolutionary origin of this behavior in humans remains poorly understood. So far, comparative studies in primates have led to mixed conclusions probably due to methodological differences relating to both task complexity a... | ['Animals', 'Behavior, Animal', 'Dogs', 'Social Behavior'] | 26,669,671 | [['B01.050'], ['F01.145.113'], ['B01.050.150.900.649.313.750.250.216.200'], ['F01.145.813']] | ['Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Ventilatory choices for intubated patients during helicopter stretcher winching. | INTRODUCTION: The winching of intubated patients on a stretcher into a helicopter is a rare event. Intermittent positive pressure ventilation is mandatory, which can either be performed manually with a self-inflating bag, or automatically using a portable ventilator. Theoretically automatic ventilation would provide im... | ['Air Ambulances', 'Aircraft', 'Humans', 'Intubation, Intratracheal', 'Manikins', 'Moving and Lifting Patients', 'Prospective Studies', 'Respiration, Artificial', 'Stretchers', 'Switzerland'] | 28,845,544 | [['J01.937.285.100.100', 'N02.421.297.879.100.100'], ['J01.937.285.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.041.500', 'E02.585.578', 'E05.497.578'], ['J01.897.280.500.545.129.400', 'L01.178.820.090.545.129.400'], ['N02.421.585.525'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.8... | ['Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 |
The clear cell variant of epithelioid intravenous leiomyomatosis of the uterus: report of a case. | A case of very rare uterine clear cell epithelioid leiomyomatosis is reported. The patient presented with a recurrent pelvic mass after hysterectomy 2 years earlier. The recurrent tumor was located mainly in the vessels of the broad ligament as worm-like plugs. The reviewed hysterectomy specimen showed a typical multi-... | ['Female', 'Humans', 'Immunohistochemistry', 'Leiomyomatosis', 'Microscopy, Electron', 'Middle Aged', 'Mitochondria', 'Neoplasms, Vascular Tissue', 'Tomography, X-Ray Computed', 'Uterine Neoplasms'] | 9,832,059 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512', 'H01.158.201.344.512', 'H01.158.201.486.512', 'H01.181.122.573.512', 'H01.181.122.605.512'], ['C04.557.450.590.450.465'], ['E01... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Diseases [C]', 'Named Groups [M]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Multiscale approach including microfibril scale to assess elastic constants of cortical bone based on neural network computation and homogenization method. | The complexity and heterogeneity of bone tissue require a multiscale modeling to understand its mechanical behavior and its remodeling mechanisms. In this paper, a novel multiscale hierarchical approach including microfibril scale based on hybrid neural network (NN) computation and homogenization equations was develope... | ['Algorithms', 'Bone and Bones', 'Collagen', 'Computer Simulation', 'Elastic Modulus', 'Finite Element Analysis', 'Humans', 'Models, Biological', 'Neural Networks, Computer'] | 24,123,969 | [['G17.035', 'L01.224.050'], ['A02.835.232', 'A10.165.265'], ['D05.750.078.280', 'D12.776.860.300.250'], ['L01.224.160'], ['G01.374.590.605'], ['E05.355'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.395'], ['G17.485', 'L01.224.050.375.605']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Energy conservation: a powerful tool for hospital cost control. | As cost control becomes increasingly important, managers are looking for ways to save money. One often overlooked area is energy conservation. Energy costs can constitute 3 to 10 percent of a hospital's budget, but with energy conservation, that amount can be reduced 20 to 40 percent. Furthermore, with an energy conser... | ['Conservation of Energy Resources', 'Conservation of Natural Resources', 'Contract Services', 'Cost Control', 'Evaluation Studies as Topic', 'Financial Management', 'Financial Management, Hospital', 'Maintenance and Engineering, Hospital'] | 10,274,486 | [['N06.230.080.078'], ['J01.256', 'N06.230.080'], ['N03.219.463.100'], ['N03.219.151.160'], ['E05.337', 'N05.715.360.335'], ['N03.219.463'], ['N02.278.216.500.875', 'N03.219.463.280', 'N04.452.442.452.180'], ['N02.278.216.500.968.450', 'N02.628.472', 'N04.452.442.452.422.450']] | ['Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Nonlinear spectroscopy. | Although nonlinear spectroscopy evolved slowly in its initial stages, it is now becoming an important new branch of atomic and molecular spectroscopy. A variety of phenomena are being observed for the first time, either in steady state or in transient behavior. In a sense, the methods of microwave and nuclear magnetic ... | ['Lasers', 'Magnetic Resonance Spectroscopy', 'Mathematics', 'Methane', 'Spectrum Analysis'] | 5,078,247 | [['E07.632.490', 'E07.710.520'], ['E05.196.867.519'], ['H01.548'], ['D02.455.326.146.571'], ['E05.196.867']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Poor uptake of hepatitis B immunization amongst hospital-based health care staff. | The uptake of hepatitis B vaccine was assessed amongst 100 medical and 100 nursing staff in a teaching hospital with a policy of recommending to those at risk that they should seek immunization from their general practitioners. Sixteen per cent of nurses and 31% of doctors had completed a course of immunization with co... | ['England', 'Hepatitis B', 'Hepatitis B Vaccines', 'Hepatitis B virus', 'Humans', 'Medical Staff, Hospital', 'Nursing Staff, Hospital', 'Occupational Diseases', 'Patient Acceptance of Health Care', 'Vaccination', 'Vaccines, Synthetic', 'Viral Hepatitis Vaccines'] | 1,829,519 | [['Z01.542.363.300'], ['C01.221.250.500', 'C01.925.256.430.400', 'C01.925.440.435', 'C06.552.380.705.437'], ['D20.215.894.899.955.400'], ['B04.280.375.650.425', 'B04.450.390.650.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.526.485.630.490', 'M01.526.485.740.422', 'N02.360.630.490', 'N02.360.740.422'], ... | ['Geographicals [Z]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Named Groups [M]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Patterns of cytomegalovirus reactivation are associated with distinct evolutive profiles of immune reconstitution after allogeneic hematopoietic stem cell transplantation. | T cell-mediated immunity is essential for the control of cytomegalovirus (CMV) infections in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). Our aims were to identify patterns of CMV-specific immune responses associated with multiple or prolonged reactivations. We analyzed findings i... | ['Antigens, CD', 'CD8-Positive T-Lymphocytes', 'Cytomegalovirus', 'Cytomegalovirus Infections', 'HLA-A Antigens', 'HLA-B Antigens', 'Hematopoietic Stem Cell Transplantation', 'Histocompatibility Antigens Class I', 'Humans', 'Leukocyte Common Antigens', 'Phenotype', 'Recurrence', 'Risk Factors', 'Tissue Donors', 'Transp... | 18,666,855 | [['D23.050.301.264.035', 'D23.101.100.110'], ['A11.118.637.555.567.569.220', 'A15.145.229.637.555.567.569.220', 'A15.382.490.555.567.569.220'], ['B04.280.382.150.150'], ['C01.925.256.466.245'], ['D12.776.395.550.489.400', 'D12.776.543.550.439.400', 'D23.050.301.500.100.400', 'D23.050.301.500.450.370', 'D23.050.705.552.... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Named Groups [M]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Erdheim-Chester disease with interatrial septum involvement. | Erdheim-Chester disease is an uncommon non-Langerhans cell histiocytosis with systemic manifestations. Most cases discuss radiologic findings once a pathologic diagnosis has already been established. We describe a patient with symptoms and no previously known diagnosis who was imaged with computed tomography, magnetic ... | ['Aged', 'Erdheim-Chester Disease', 'Heart', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Myocardium', 'Positron-Emission Tomography', 'Tomography, X-Ray Computed'] | 21,681,117 | [['M01.060.116.100'], ['C15.604.250.410.224'], ['A07.541'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['A02.633.580', 'A07.541.704', 'A10.690.552.750'], ['E01.370.350.350.800.700', 'E01.370.350.600.350.800.399', 'E01.370.350.710.800.399', 'E01.370.350.825.800.399', 'E01.370.384.730.800.3... | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A microcomputer program for exact and asymptotic analysis of several 2 x 2 tables. | A microcomputer program for analysis of a binomial proportion and the common odds ratio in a series of 2 x 2 tables is presented. This program utilizes both exact and asymptotic methods to provide point estimates, P values, and confidence intervals. Modifications of the exact method based on the concept of a mid-P valu... | ['Algorithms', 'Confidence Intervals', 'Epidemiologic Methods', 'Microcomputers', 'Odds Ratio', 'Software'] | 2,054,406 | [['G17.035', 'L01.224.050'], ['E05.318.740.275', 'N05.715.360.750.220', 'N06.850.520.830.275'], ['E05.318', 'N06.850.520'], ['L01.224.230.260.550'], ['E05.318.740.600.600', 'G17.680.500', 'N05.715.360.750.625.590', 'N06.850.520.830.600.600'], ['L01.224.900']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Genetic characterization of near full length SIVdrl genomes from four captive drills (Mandrillus leucophaeus). | We sequenced near full length SIVdrl genomes from four captive drills (Mandrillus leucophaeus). All four animals were born in captivity in German zoos. Although serologically SIV negative before acquisition in zoo A in 2008 and 2009, during a routine analysis all four animals were determined to be SIV antibody positive... | ['Animals', 'Animals, Zoo', 'Cluster Analysis', 'Female', 'Genetic Variation', 'Genome, Viral', 'Germany', 'Male', 'Mandrillus', 'Molecular Sequence Data', 'Phylogeny', 'Sequence Analysis, DNA', 'Sequence Homology', 'Simian Acquired Immunodeficiency Syndrome', 'Simian Immunodeficiency Virus'] | 25,523,403 | [['B01.050'], ['B01.050.050.448'], ['E05.318.740.250', 'N05.715.360.750.200', 'N06.850.520.830.250'], ['G05.365'], ['G05.360.340.358.840'], ['Z01.542.315'], ['B01.050.150.900.649.313.988.400.112.199.120.530'], ['L01.453.245.667'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['E05.393.760.700'], ['G02.111.810', 'G05.810'... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Information Science [L]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 |
Ontogeny of surfactant proteins A and B in human amniotic fluid as indices of fetal lung maturity. | Surfactant proteins A and B (SP-A and SP-B) were measured in human amniotic fluid by ELISA and correlated with lecithin to sphingomyelin ratio (L/S), phosphatidylglycerol (PG), and perinatal outcome. Amniotic fluid SP-A, SP-B, and L/S increased with advancing gestation. SP-A was detected at 19 wk gestation and increase... | ['Amniotic Fluid', 'Enzyme-Linked Immunosorbent Assay', 'Female', 'Fetal Organ Maturity', 'Gestational Age', 'Humans', 'Infant, Newborn', 'Lung', 'Male', 'Pregnancy', 'Prenatal Diagnosis', 'Proteolipids', 'Pulmonary Surfactant-Associated Protein A', 'Pulmonary Surfactant-Associated Proteins', 'Pulmonary Surfactants', '... | 1,805,157 | [['A12.098', 'A16.378.149'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['G07.345.500.325.235.750', 'G07.345.500.325.377.249', 'G08.686.784.170.157.750'], ['G07.345.500.325.235.968', 'G08.686.320'], ['B01.050.150.900.649.313.988.400.112.400.400']... | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Augmentation of hemagglutination-inhibition (HI) antibodies in gilts of breeding age by large dosages of human A/New Jersey/76 influenza vaccine. | Fifteen gilts of breeding age were studied. Four received three 4 ml. doses three weeks apart of an experimental killed swine influenza vaccine containing A/Swine/ill/65 antigen, four received three ml. doses three weeks apart of a human influenza vaccine containing A/New Jersey/76 antigen and three received two doses... | ['Animals', 'Antibody Formation', 'Female', 'Hemagglutination Inhibition Tests', 'Influenza A virus', 'Influenza Vaccines', 'Swine'] | 461,965 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Comparison of disc diffusion results with minimum inhibitory concentration (MIC) values for antimicrobial susceptibility testing of Neisseria gonorrhoeae. | BACKGROUND & OBJECTIVE: objectives: As antimicrobial susceptibility testing of Neisseria gonorrhoeae provides guidance for appropriate treatment, there is a need for simple, reliable and cost-effective method for susceptibility testing. The present study was aimed to compare the results of two methods of susceptibility... | ['Anti-Bacterial Agents', 'Anti-Infective Agents', 'Ceftriaxone', 'Ciprofloxacin', 'Humans', 'Male', 'Microbial Sensitivity Tests', 'Neisseria gonorrhoeae', 'Penicillins'] | 16,106,090 | [['D27.505.954.122.085'], ['D27.505.954.122'], ['D02.065.589.099.249.190.190.155', 'D02.886.665.074.190.190.155', 'D03.633.100.300.249.190.190.155'], ['D03.633.100.810.835.322.186'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.875.595', 'E05.200.875.595', 'E05.337.550.400'], ['B03.440.400.425.550.550... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Impaired trabecular and cortical microarchitecture in daughters of women with osteoporotic fracture: the MODAM study. | UNLABELLED: We investigated the familial resemblance of bone microarchitecture parameters between postmenopausal mothers with fragility fracture and their premenopausal daughters using high-resolution peripheral quantitative computed tomography (HR-pQCT). We found that daughters of women with fracture have lower total ... | ['Adult', 'Aged', 'Aged, 80 and over', 'Bone Density', 'Cross-Sectional Studies', 'Female', 'Humans', 'Middle Aged', 'Osteoporotic Fractures', 'Premenopause', 'Radius', 'Tibia', 'Tomography, X-Ray Computed'] | 23,179,577 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['G11.427.100'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C26.404.545'], ['G08.686.157.500.812', 'G08.686.841.249.500.812'], ['A02.835.232.087.090... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Spectrophotometric micromethod to determine L-lysine-alpha-oxidase activity]. | A spectrophotometric micromethod is developed for estimation of L-lysine-alpha-oxidase. The method is based on measurement of hydrogen peroxide formed in enzymatic oxidation of L-lysine. Optimal conditions were developed for estimation of the enzymatic activity in the extracts of Trichoderma sp. The saturating concentr... | ['Amino Acid Oxidoreductases', 'Hydrogen Peroxide', 'Mitosporic Fungi', 'Oxidation-Reduction', 'Spectrophotometry', 'Trichoderma'] | 6,538,725 | [['D08.811.682.664.500'], ['D01.248.497.158.685.750.424', 'D01.339.431.374.424', 'D01.650.550.750.400', 'D02.389.338.253'], ['B01.300.381'], ['G02.700', 'G03.295.531'], ['E05.196.712.726', 'E05.196.867.826'], ['B01.300.381.910']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The Application of ATR-FTIR Spectroscopy and the Reversible DNA Conformation as a Sensor to Test the Effectiveness of Platinum(II) Anticancer Drugs. | Platinum(II) complexes have been found to be effective against cancer cells. Cisplatin curbs cell replication by interacting with the deoxyribonucleic acid (DNA), reducing cell proliferation and eventually leading to cell death. In order to investigate the ability of platinum complexes to affect cancer cells, two examp... | ['Animals', 'Antineoplastic Agents', 'Biosensing Techniques', 'Cattle', 'Cisplatin', 'DNA', 'Nucleic Acid Conformation', 'Platinum', 'Principal Component Analysis', 'Spectroscopy, Fourier Transform Infrared'] | 30,563,229 | [['B01.050'], ['D27.505.954.248'], ['E05.601.043'], ['B01.050.150.900.649.313.500.380.271'], ['D01.210.375', 'D01.625.125', 'D01.710.100'], ['D13.444.308'], ['G02.111.570.820.486', 'G05.360.580'], ['D01.268.556.690', 'D01.268.956.734', 'D01.552.544.690'], ['E05.318.740.562'], ['E05.196.712.726.676.700', 'E05.196.867.82... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Accuracy of teen and parental reports of obesity and body mass index. | OBJECTIVES: Adolescent obesity is becoming an increasing public health problem. This study determines: 1) differences in teen and parental report of obesity, 2) amount of misclassification using body mass index (BMI) from self-reported versus measured height and weight as an indicator of obesity, and 3) whether misclas... | ['Adolescent', 'Body Height', 'Body Mass Index', 'Body Weight', 'Female', 'Humans', 'Longitudinal Studies', 'Male', 'Obesity', 'Parents', 'Self-Assessment', 'Sensitivity and Specificity', 'Social Class'] | 10,878,149 | [['M01.060.057'], ['E01.370.600.115.100.160.100', 'E05.041.124.160.500', 'G07.100.100.160.100', 'G07.345.249.314.100'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Acquisition of hearing aids and assistive listening devices among the pediatric hearing-impaired population. | Sufficient access to health care is of concern to the indigent population in the US and to their health care providers. This study was undertaken to elucidate the rate of the follow-up among lower socioeconomic hearing-impaired pediatric patients who had received a recommendation for hearing aids and/or assistive liste... | ['Adolescent', 'Child', 'Child, Preschool', 'Correction of Hearing Impairment', 'Data Collection', 'Health Services Accessibility', 'Hearing Aids', 'Humans', 'Infant', 'Medical Indigency', 'Patient Compliance', 'Referral and Consultation', 'Tennessee'] | 10,841,954 | [['M01.060.057'], ['M01.060.406'], ['M01.060.406.448'], ['E02.760.169.063.500.200', 'E02.831.200', 'H02.403.680.600.500', 'N02.421.784.377'], ['E05.318.308', 'L01.399.250', 'N05.715.360.300', 'N06.850.520.308'], ['N04.590.374.350', 'N05.300.430'], ['E07.305.906.500', 'E07.814.458'], ['B01.050.150.900.649.313.988.400.11... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Information Science [L]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 |
[Surgical access for small-sized lung lesions]. | Experience of diagnostics and surgical treatment of of 100 patients with small-sized lung lesions was analyzed. Thus, authors pose, that patients with lung focal lesion less than 10mm in diameter, should have a lung resection, performed from minithoracotomy. Videthotacoscopic lung biopsy is appropriate by multiple foca... | ['Biopsy', 'Diagnosis, Differential', 'Humans', 'Lung Diseases', 'Pneumonectomy', 'Retrospective Studies', 'Thoracic Surgery, Video-Assisted', 'Tomography, X-Ray Computed', 'Treatment Outcome'] | 19,770,818 | [['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['E01.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C08.381'], ['E04.620', 'E04.928.600.600'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.3... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Molecular identification of tuliposide B-converting enzyme: a lactone-forming carboxylesterase from the pollen of tulip. | 6-Tuliposides A (PosA) and B (PosB), which are the major secondary metabolites in tulip (Tulipa gesneriana), are enzymatically converted to the antimicrobial lactonized aglycons, tulipalins A (PaA) and B (PaB), respectively. We recently identified a PosA-converting enzyme (TCEA) as the first reported member of the lact... | ['Carboxylic Ester Hydrolases', 'Catalysis', 'Glucosides', 'Lactones', 'Molecular Sequence Data', 'Pollen', 'RNA, Messenger', 'Tulipa'] | 25,997,073 | [['D08.811.277.352.100'], ['G02.130'], ['D09.408.348'], ['D02.540'], ['L01.453.245.667'], ['A18.024.249.500.249.500'], ['D13.444.735.544'], ['B01.650.940.800.575.912.250.618.875.500.786']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Transboundary smoke haze pollution in Malaysia: inpatient health impacts and economic valuation. | This study assessed the economic value of health impacts of transboundary smoke haze pollution in Kuala Lumpur and adjacent areas in the state of Selangor, Malaysia. Daily inpatient data from 2005, 2006, 2008, and 2009 for 14 haze-related illnesses were collected from four hospitals. On average, there were 19 hazy days... | ['Air Pollutants', 'Air Pollution', 'Cardiovascular Diseases', 'Cost of Illness', 'Health Impact Assessment', 'Hospitalization', 'Humans', 'Inpatients', 'Malaysia', 'Respiratory Tract Diseases', 'Smoke'] | 24,682,070 | [['D27.888.284.101'], ['N06.850.460.100'], ['C14'], ['N03.219.151.165', 'N05.715.360.300.800.438.375.182', 'N06.850.520.308.980.438.475.046'], ['E05.318.308.237', 'N03.349.380.210.500'], ['E02.760.400', 'N02.421.585.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.643.470'], ['Z01.252.145.487'], ['C08'], [... | ['Chemicals and Drugs [D]', 'Health Care [N]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Nonmedical prescription stimulant use among youth in the emergency department: prevalence, severity and correlates. | This study examined the prevalence, severity and correlates of nonmedical prescription stimulant use (NPSU) among youth in the emergency department (ED). Participants 14-20 years old presenting to the ED completed a survey. A multinomial logistic regression was used to compare those without NPSU, with mild NPSU and wit... | ['Adolescent', 'Adult', 'Central Nervous System Stimulants', 'Emergency Service, Hospital', 'Female', 'Humans', 'Male', 'Prescription Drug Misuse', 'Prevalence', 'Risk', 'Severity of Illness Index', 'Substance-Related Disorders', 'Violence', 'Young Adult'] | 25,012,553 | [['M01.060.057'], ['M01.060.116'], ['D27.505.696.282', 'D27.505.954.427.220'], ['N02.278.216.500.968.336', 'N02.421.297.195', 'N04.452.442.452.422.336'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.306.500'], ['E05.318.308.985.525.750', 'N01.224.935.597.750', 'N06.850.505.400.975.525.750', 'N06.850.520.3... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Measurements of Retinal Perfusion Using Laser Speckle Flowgraphy and Doppler Optical Coherence Tomography. | Purpose: This study evaluated the validity of retinal perfusion measurements using laser speckle flowgraphy (LSFG) by means of in vitro experiments and direct comparison with dual-beam Doppler optical coherence tomography (D-OCT) in a healthy Caucasian population.Methods: The flow velocity of scattering solution pumped... | ['Adult', 'Female', 'Healthy Volunteers', 'Humans', 'Laser-Doppler Flowmetry', 'Male', 'Prospective Studies', 'Regional Blood Flow', 'Reproducibility of Results', 'Retinal Vessels', 'Tomography, Optical Coherence'] | 27,756,076 | [['M01.060.116'], ['M01.774.500', 'M01.955.236'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.370.475', 'E05.830.500'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['G09.330.100.780'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.44... | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Control of viral replication and disease onset in cynomolgus monkeys by HIV-1 TAT vaccine. | The Tat protein of HIV is produced early after infection and it is essential for viral replication and transmission. Tat is released by infected lymphocytes and is detected in the serum of HIV-infected patients. Extracellular Tat enters cells, where promotes HIV replication. Several studies suggest that humoral and cel... | ['AIDS Vaccines', 'Acquired Immunodeficiency Syndrome', 'Animals', 'CD4 Lymphocyte Count', 'Gene Products, tat', 'HIV Antibodies', 'Macaca fascicularis', 'T-Lymphocytes, Cytotoxic', 'Tumor Necrosis Factor-alpha', 'Vaccination', 'Virus Replication', 'tat Gene Products, Human Immunodeficiency Virus'] | 10,763,887 | [['D20.215.894.899.050'], ['C01.221.250.875.040', 'C01.221.812.640.400.040', 'C01.778.640.400.040', 'C01.925.782.815.616.400.040', 'C01.925.813.400.040', 'C01.925.839.040', 'C20.673.480.040'], ['B01.050'], ['E01.370.225.500.195.107.595.500.150', 'E01.370.225.625.107.595.500.150', 'E05.200.500.195.107.595.500.150', 'E05... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
The role of polio-vaccine in pleural mesothelioma--an epidemiological observation. | From the Croatian Cancer Registry (period 1991-1997) 194 malignant pleural mesothelioma patients were collected. According to participation in polio vaccination mass campaign in 1961 that covered the entire Croatian population aged 3 months to 20 years, mesothelioma patients were divided in vaccinated (N=58), and non-v... | ['Adult', 'Aged', 'Aged, 80 and over', 'Asbestos', 'Drug Contamination', 'Female', 'Humans', 'Male', 'Mesothelioma', 'Middle Aged', 'Occupational Exposure', 'Pleural Neoplasms', 'Poliovirus Vaccines', 'Simian virus 40'] | 18,756,898 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D01.578.725.050', 'D01.837.725.700.760.070'], ['N06.850.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.470.035.510', 'C04.557.470.660.510'], ['M01.060.116.630'], ['N06.850.460.350.600'], ['C04.588.894.797.640', 'C08.528.694', 'C08.785.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Cardiac myosin-binding protein C is a novel marker of myocardial injury and fibrosis in aortic stenosis. | OBJECTIVE: Cardiac myosin-binding protein C (cMyC) is an abundant sarcomeric protein and novel highly specific marker of myocardial injury. Myocyte death characterises the transition from hypertrophy to replacement myocardial fibrosis in advanced aortic stenosis. We hypothesised that serum cMyC concentrations would be ... | ['Aged', 'Aged, 80 and over', 'Aortic Valve Stenosis', 'Biomarkers', 'Cardiomegaly', 'Carrier Proteins', 'Case-Control Studies', 'Cell Death', 'Contrast Media', 'Female', 'Fibrosis', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Myocardium', 'Predictive Value of Tests', 'Prognosis', 'Risk Factors', 'S... | 29,196,542 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['C14.280.484.048.750', 'C14.280.955.249'], ['D23.101'], ['C14.280.195', 'C23.300.775.250'], ['D12.776.157'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['G04.146'], ['D27.505.259.500', 'D27.720.259'], ['C23.550.355'], ['B01.050.150.900.... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Supramolecular Complex of Ibuprofen with Larch Polysaccharide Arabinogalactan: Studies on Bioavailability and Pharmacokinetics. | BACKGROUND AND OBJECTIVES: In the present work, pharmacological and pharmacokinetic properties of the supramolecular complex of non-steroid anti-inflammatory drug ibuprofen (IBU) with natural polysaccharide arabinogalactan (AG) were studied. The main goals of such complexation were the increase of ibuprofen's bioavaila... | ['Animals', 'Anti-Inflammatory Agents, Non-Steroidal', 'Biological Availability', 'Calorimetry, Differential Scanning', 'Chemistry, Pharmaceutical', 'Drug Combinations', 'Galactans', 'Ibuprofen', 'Larix', 'Male', 'Mice', 'Polysaccharides', 'Rats', 'Rats, Wistar', 'Solubility'] | 27,351,190 | [['B01.050'], ['D27.505.696.663.850.014.040.500', 'D27.505.954.158.030', 'D27.505.954.329.030'], ['G03.787.151', 'G07.690.725.129'], ['E05.196.131.310', 'E05.196.370.310'], ['H01.158.703.007', 'H01.181.466'], ['D26.310'], ['D09.698.360'], ['D02.241.223.701.430'], ['B01.650.940.800.575.912.625.875.444'], ['B01.050.150.9... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
ChloroplastDB: the Chloroplast Genome Database. | The Chloroplast Genome Database (ChloroplastDB) is an interactive, web-based database for fully sequenced plastid genomes, containing genomic, protein, DNA and RNA sequences, gene locations, RNA-editing sites, putative protein families and alignments (http://chloroplast.cbio.psu.edu/). With recent technical advances, t... | ['Chloroplasts', 'Database Management Systems', 'Databases, Genetic', 'Eukaryota', 'Genome, Plant', 'Genomics', 'Internet', 'RNA Editing', 'Sequence Analysis, DNA', 'Sequence Analysis, Protein', 'Sequence Analysis, RNA', 'User-Computer Interface'] | 16,381,961 | [['A11.284.430.214.190.875.700.140'], ['L01.224.068', 'L01.224.900.280', 'N04.452.515.110'], ['L01.313.500.750.300.188.400.325', 'L01.470.750.750.325'], ['B01'], ['G05.360.340.365'], ['H01.158.273.180.350', 'H01.158.273.343.350'], ['L01.224.230.110.500'], ['G02.111.760.250', 'G03.839.250', 'G05.308.700.250'], ['E05.393... | ['Anatomy [A]', 'Information Science [L]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
[Esthesioneuroblastoma of the nose in a child]. | A rare case of nasal esthesioneuroblastoma in a 5-year-old child is described. The tumor involved the maxillary and ethmoid sinuses, destroyed superior compartments of nasal septum and medial wall of left orbit. In spite of the advanced process, there were hardly any clinical manifestations. Radical surgery with tumor ... | ['Biopsy', 'Child, Preschool', 'Epithelium', 'Ethmoid Sinus', 'Humans', 'Male', 'Maxillary Sinus Neoplasms', 'Nasal Mucosa', 'Neuroectodermal Tumors, Primitive, Peripheral', 'Nose Neoplasms', 'Paranasal Sinus Neoplasms'] | 3,606,419 | [['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['M01.060.406.448'], ['A10.272'], ['A04.531.621.267'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.443.665.650.693.575', 'C08.460.669.693.575', 'C08.460.692.503.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Design of chiral LC separations for calcium antagonists on alpha 1-acid glycoprotein and ovomucoid columns. | Three chiral calcium antagonist drugs, gallopamil and two dihydropyridine derivatives, have been successfully separated within short retention times using both the alpha 1-acid glycoprotein chiral stationary phase (Chiral-AGP) and the ovomucoid column (Ultron ES-OVM). Aqueous buffer at defined pH is modified by the add... | ['Calcium Channel Blockers', 'Chromatography, High Pressure Liquid', 'Dihydropyridines', 'Gallopamil', 'Hydrogen-Ion Concentration', 'Orosomucoid', 'Ovomucin', 'Stereoisomerism', 'Verapamil'] | 1,298,397 | [['D27.505.519.562.249', 'D27.505.696.260.500', 'D27.505.954.411.192'], ['E05.196.181.400.300'], ['D03.383.725.203'], ['D02.092.471.683.953.395'], ['G02.300'], ['D12.776.124.050.600', 'D12.776.124.790.106.640', 'D12.776.377.715.085.640', 'D12.776.395.560.742'], ['D12.776.256.159.157.675', 'D12.776.290.675', 'D12.776.39... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Two-dimensional echocardiographic left- atrial-to-aortic ratio in healthy adult dogs: a reexamination of reference intervals. | INTRODUCTION: Left atrial-to-aortic ratios (LA:Ao) provide a body weight independent estimate of left atrial size. However, reference intervals were established with small sample populations and for only single points in the cardiac cycle. More robust reference intervals are warranted.ANIMALS: Two hundred and thirty ei... | ['Animals', 'Dogs', 'Echocardiography', 'Female', 'Heart', 'Humans', 'Male', 'Reference Values'] | 31,794,915 | [['B01.050'], ['B01.050.150.900.649.313.750.250.216.200'], ['E01.370.350.130.750', 'E01.370.350.850.220', 'E01.370.370.380.220'], ['A07.541'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.978.810']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Levels and prognostic impact of circulating markers of inflammation, endothelial activation and extracellular matrix remodelling in patients with lung cancer and chronic obstructive pulmonary disease. | BACKGROUND: The development of both chronic obstructive pulmonary disease (COPD) and lung cancer (LC) is influenced by smoking related chronic pulmonary inflammation caused by an excessive innate immune response to smoke exposure. In addition, the smoking induced formation of covalent bonds between the carcinogens and ... | ['Adult', 'Aged', 'Biomarkers', 'Endothelium, Vascular', 'Extracellular Matrix', 'Female', 'Humans', 'Inflammation', 'Lung Neoplasms', 'Male', 'Middle Aged', 'Prognosis', 'Pulmonary Disease, Chronic Obstructive'] | 30,005,623 | [['M01.060.116'], ['M01.060.116.100'], ['D23.101'], ['A07.015.700.500', 'A10.272.491.355'], ['A11.284.295.310'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.470'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['M01.060.116.630'], ['E01.789'], ['C08.381.495.389']] | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Effects of youth tobacco access and possession policy interventions on heavy adolescent smokers. | This study evaluated the effects of tobacco PUP (Purchase, Use and Possession) laws on tobacco use patterns among students in twenty-four towns, which were randomly assigned into an experimental and a control group. The experimental group involved both PUP law enforcement and reducing minors' access to commercial sourc... | ['Adolescent', 'Commerce', 'Humans', 'Illinois', 'Law Enforcement', 'Smoking', 'Smoking Prevention'] | 19,440,265 | [['M01.060.057'], ['J01.219'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.107.567.875.350.350', 'Z01.107.567.875.510.350'], ['I01.880.604.594'], ['F01.145.805'], ['I02.233.332.812', 'N02.421.726.407.840']] | ['Named Groups [M]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Psychiatry and Psychology [F]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
Age and gender correlates of pulling in pediatric trichotillomania. | OBJECTIVE: Our goals were to examine clinical characteristics and age and gender correlates in pediatric trichotillomania.METHOD: A total of 62 children (8-17 years of age) were recruited for a pediatric trichotillomania treatment trial and characterized using structured rating scales of symptoms of hairpulling and com... | ['Adolescent', 'Age Factors', 'Anxiety Disorders', 'Child', 'Comorbidity', 'Cross-Sectional Studies', 'Depressive Disorder', 'Female', 'Humans', 'Male', 'Psychiatric Status Rating Scales', 'Randomized Controlled Trials as Topic', 'Severity of Illness Index', 'Sex Factors', 'Trichotillomania'] | 23,452,681 | [['M01.060.057'], ['N05.715.350.075', 'N06.850.490.250'], ['F03.080'], ['M01.060.406'], ['N05.715.350.225', 'N06.850.490.687'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['F03.600.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F04.711.513.653'], ['E05.318.372.250.250.365.... | ['Named Groups [M]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Isolated Left Brachiocephalic Artery in Transposition of the Great Arteries. | Isolation of an artery is a rare congenital defect in which a vessel arises anomalously from the pulmonary arteries rather than the aorta. Isolated left subclavian artery and (less commonly) isolated left brachiocephalic artery have been described in association with various complex congenital heart defects. We present... | ['Angiography', 'Aorta, Thoracic', 'Arterial Switch Operation', 'Brachiocephalic Trunk', 'Cardiac Catheterization', 'Echocardiography', 'Humans', 'Infant, Newborn', 'Male', 'Pulmonary Artery', 'Subclavian Artery', 'Transposition of Great Vessels'] | 30,269,835 | [['E01.370.350.700.060', 'E01.370.370.050'], ['A07.015.114.056.372'], ['E04.100.376.031', 'E04.928.220.055'], ['A07.015.114.145'], ['E01.370.370.380.140', 'E02.148.442', 'E05.157.250'], ['E01.370.350.130.750', 'E01.370.350.850.220', 'E01.370.370.380.220'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Named Groups [M]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Long-term follow-up of hyperprolactinemic women treated with bromocriptine. | Seventy-five women with hyperprolactinemia and demonstrable or suspected prolactinomas were treated with bromocriptine only and followed for 5 to 9 years. Biochemical, radiologic, and clinical responses were generally maintained in the long term, once established in the short term. Underlying mass effects on neurologic... | ['Adenoma', 'Adult', 'Aged', 'Bromocriptine', 'Female', 'Follow-Up Studies', 'Humans', 'Hypogonadism', 'Menstruation', 'Middle Aged', 'Pituitary Gland, Anterior', 'Pituitary Neoplasms', 'Pregnancy', 'Pregnancy Complications', 'Prolactin', 'Time Factors'] | 6,628,704 | [['C04.557.470.035'], ['M01.060.116'], ['M01.060.116.100'], ['D03.132.327.412.100', 'D03.633.400.439.131', 'D03.633.400.562.100'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C19.391.482'], ['G08.686.605.428'], ['M01.060.1... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Overexpression of MHC class I in muscle of lymphocyte-deficient mice causes a severe myopathy with induction of the unfolded protein response. | Muscle fibers do not normally express major histocompatibility complex class I (MHC-I) molecules, and their reexpression is a hallmark of inflammatory myopathies. It has been shown in mice that overexpression of MHC-I induces a poorly inflammatory myositis accompanied by the unfolded protein response (UPR), but it is u... | ['Animals', 'Endoplasmic Reticulum Stress', 'Histocompatibility Antigens Class I', 'Humans', 'Immunohistochemistry', 'Intracellular Space', 'Mice', 'Mice, SCID', 'Mice, Transgenic', 'Muscle Fibers, Skeletal', 'Muscle Proteins', 'Muscles', 'Muscular Diseases', 'Myositis, Inclusion Body', 'T-Lymphocytes', 'Unfolded Prote... | 23,850,081 | [['B01.050'], ['G04.434'], ['D12.776.395.550.489', 'D12.776.543.550.439', 'D23.050.301.500.100', 'D23.050.705.552.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512', 'H01.15... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Proteomic analysis of human mesenteric lymph. | Extensive animal work has established mesenteric lymph as the mechanistic link between gut ischemia/reperfusion and distant organ injury. Our trauma and transplant services provide a unique opportunity to assess the relevance of our animal data to human mesenteric lymph under conditions that simulate those used in the ... | ['Acute-Phase Proteins', 'Carrier Proteins', 'Cells, Cultured', 'Chromatography, Liquid', 'Electrophoresis, Polyacrylamide Gel', 'Hemolysis', 'Humans', 'Lymph Nodes', 'Membrane Glycoproteins', 'Mesentery', 'Mitochondrial Proteins', 'Neutrophils', 'Oxidative Stress', 'Proteomics', 'Superoxides', 'Tandem Mass Spectrometr... | 21,192,285 | [['D12.776.124.050'], ['D12.776.157'], ['A11.251'], ['E05.196.181.400'], ['E05.196.401.402', 'E05.301.300.319'], ['C23.550.403', 'G12.122.545'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A10.549.400', 'A15.382.520.604.412'], ['D12.776.395.550', 'D12.776.543.550'], ['A01.923.047.025.600.451'], ['D12.776.575'], ... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
NOD2 activation induces oxidative stress contributing to mitochondrial dysfunction and insulin resistance in skeletal muscle cells. | Nucleotide-binding oligomerization domain protein-2 (NOD2) activation in skeletal muscle cells has been associated with insulin resistance, but the underlying mechanisms are not yet clear. Here we demonstrate the implication of oxidative stress in the development of mitochondrial dysfunction and insulin resistance in r... | ['Animals', 'Apoptosis', 'Blotting, Western', 'Cells, Cultured', 'Immunoenzyme Techniques', 'Insulin Resistance', 'Membrane Potential, Mitochondrial', 'Mitochondria', 'Muscle Fibers, Skeletal', 'Muscle, Skeletal', 'Nod2 Signaling Adaptor Protein', 'Oxidative Stress', 'Phosphorylation', 'RNA, Messenger', 'Rats', 'Reacti... | 26,404,168 | [['B01.050'], ['G04.146.954.035'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['A11.251'], ['E05.478.566.350', 'E05.478.583.400', 'E05.601.470.350'], ['C18.452.394.968.500', 'G07.690.773.984.617'], ['G03.295.770.500', 'G04.580.550', 'G07.265.675.550'], ['A11.284... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The effects of sex steroid hormones and interleukin-1-beta on MUC1 expression in endometrial epithelial cell lines. | Oestrogen, progesterone and paracrine signals from the embryo have been associated with the overall control of implantation. Changes in the expression of the heavily glycosylated transmembrane glycoprotein MUC1 mucin on the endometrial epithelium are also thought to be important for embryo attachment. Increased MUC1 ex... | ['Antigens, Neoplasm', 'Cell Line, Tumor', 'Endometrium', 'Epithelial Cells', 'Estrogens', 'Female', 'Flow Cytometry', 'Gene Expression', 'Humans', 'Immunohistochemistry', 'Interleukin-1', 'Mucin-1', 'Mucins', 'Progesterone', 'Promoter Regions, Genetic', 'Receptors, Estrogen', 'Receptors, Progesterone', 'Up-Regulation'... | 16,595,724 | [['D23.050.285'], ['A11.251.210.190', 'A11.251.860.180'], ['A05.360.319.679.490'], ['A11.436'], ['D27.505.696.399.472.277'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.200.500.386.350', 'E05.242.363.342', 'E05.242.386.350'], ['G05.297'], ['B01.050.1... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Paradoxical effects of PDGF-BB overexpression in endothelial cells on engineered blood vessels in vivo. | Therapeutic revascularization with either exogenous angiogenic growth factors or vascular cells has yet to demonstrate efficacy in the clinic. Injection of angiogenic growth factors often produces unstable and abnormal blood vessels. Blood vascular networks derived from implanted endothelial cells persist only transien... | ['Animals', 'Becaplermin', 'Blood Vessels', 'Blotting, Western', 'Cell Movement', 'Cell Proliferation', 'Cell Survival', 'Chemokine CCL2', 'Chemokine CCL7', 'Endothelial Cells', 'Enzyme-Linked Immunosorbent Assay', 'Humans', 'In Situ Nick-End Labeling', 'Mice', 'Mice, SCID', 'Neovascularization, Physiologic', 'Platelet... | 19,477,947 | [['B01.050'], ['D12.644.276.910.650.500', 'D12.776.260.690.500', 'D12.776.467.910.650.500', 'D23.529.910.650.500'], ['A07.015'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['G04.198', 'G07.568.500.180'], ['G04.161.750', 'G07.345.249.410.750'], ['G04.346'], ['D12... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Loss of glycemic control in patients with type 2 diabetes mellitus who were receiving initial metformin, sulfonylurea, or thiazolidinedione monotherapy. | STUDY OBJECTIVES: To examine glycosylated hemoglobin (A1C) values longitudinally in patients who newly started metformin, sulfonylurea, or thiazolidinedione monotherapy; in a subset of patients whose A1C values were 7% or greater before starting therapy (baseline) and who achieved A1C goal (A1C < 7%) during therapy, ra... | ['Administration, Oral', 'Adult', 'Diabetes Mellitus, Type 2', 'Female', 'Glycated Hemoglobin A', 'Humans', 'Hypoglycemic Agents', 'Longitudinal Studies', 'Male', 'Metformin', 'Middle Aged', 'Retrospective Studies', 'Sulfonylurea Compounds', 'Thiazolidinediones', 'Treatment Failure'] | 17,655,510 | [['E02.319.267.100'], ['M01.060.116'], ['C18.452.394.750.149', 'C19.246.300'], ['D09.400.430.937', 'D12.776.124.400.405.440', 'D12.776.395.381', 'D12.776.422.316.762.380.440'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.422'], ['E05.318.372.500.750.500', 'N05.715.360.330.500.750.500', 'N06.850.520.4... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
An overview of the Heidelberg Retina Tomograph. | BACKGROUND: The Heidelberg Retina Tomograph (HRT) is a new ophthalmic diagnostic instrument which uses confocal laser scanning microscopy to quantify precisely, in vivo, the topography of the posterior fundus. HRT technology permits accurate, highly reproducible documentation of the posterior fundus, along with softwar... | ['Adult', 'Aged', 'Female', 'Fundus Oculi', 'Glaucoma', 'Humans', 'Male', 'Microscopy, Confocal', 'Optic Disk', 'Optic Nerve', 'Reproducibility of Results', 'Tomography'] | 8,888,876 | [['M01.060.116'], ['M01.060.116.100'], ['A09.371.729.313'], ['C11.525.381'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.515.395', 'E05.595.395'], ['A08.800.800.120.680.660', 'A09.371.729.690'], ['A08.800.800.120.680'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'],... | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Clinical features of schwannomatosis: a retrospective analysis of 87 patients. | BACKGROUND: Schwannomatosis is a recently recognized form of neurofibromatosis characterized by multiple noncutaneous schwannomas, a histologically benign nerve sheath tumor. As more cases are identified, the reported phenotype continues to expand and evolve. We describe the spectrum of clinical findings in a cohort of... | ['Adolescent', 'Adult', 'Aged', 'Child', 'Cohort Studies', 'Female', 'Humans', 'Male', 'Middle Aged', 'Neurilemmoma', 'Neurofibromatoses', 'Retrospective Studies', 'Skin Neoplasms', 'Young Adult'] | 22,927,469 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.406'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C04.557.465.625.650.595', 'C04.557.580.600.610.595', 'C04.557.580.625.650.595'], ['C04.557.580.6... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
In vivo binding partners of the Lens culinaris lectin. | The immobilized lectin from the lentil (Lens culinaris) specifically binds two fractions out of the L. culinaris seed globulins. Both fractions are displaced from the lectin at low pH values. In addition, fraction I fails to interact at high ionic strengths, and fraction II in the presence of glucose or other lectin-sp... | ['Albumins', 'Chromatography, Affinity', 'Electrophoresis, Polyacrylamide Gel', 'Fabaceae', 'Globulins', 'Glycoside Hydrolases', 'Hemagglutination', 'Isoelectric Focusing', 'Lectins', 'Molecular Weight', 'Nephelometry and Turbidimetry', 'Plant Lectins', 'Plant Proteins', 'Plants, Medicinal', 'Protein Binding'] | 3,675,873 | [['D12.776.034'], ['E05.196.181.400.170'], ['E05.196.401.402', 'E05.301.300.319'], ['B01.650.940.800.575.912.250.401'], ['D12.776.377'], ['D08.811.277.450'], ['G02.111.026.500', 'G12.122.100.200'], ['E05.196.401.663', 'E05.301.300.663'], ['D12.776.503'], ['G02.494'], ['E05.196.712.650'], ['D12.776.503.499', 'D12.776.76... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Structural heterogeneity and genomic distribution of Drosophila melanogaster LTR-retrotransposons. | Structural heterogeneity of five long terminal repeat (LTR) retrotransposon families (297, mdg 1, 412, copia, and 1731) was investigated in Drosophila melanogaster. The genomic distribution of canonical and rearranged elements was studied by comparing hybridization patterns of Southern blots on salivary glands from adu... | ['Animals', 'Drosophila melanogaster', 'Gene Rearrangement', 'Genetic Variation', 'Genome', 'Retroelements', 'Terminal Repeat Sequences'] | 12,644,561 | [['B01.050'], ['B01.050.500.131.617.720.500.500.750.310.250.500'], ['G05.344'], ['G05.365'], ['G05.360.340'], ['D13.444.308.760', 'G02.111.570.080.708.330.800', 'G05.360.080.708.330.800', 'G05.360.340.024.425.800'], ['G02.111.570.080.708.850', 'G05.360.080.708.850']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Metastatic meningioma: positron emission tomography CT imaging findings. | The imaging findings of a case of metastasing meningioma are described. The case illustrates a number of rare and interesting features. The patient presented with haemoptysis 22 years after the initial resection of an intracranial meningioma. CT demonstrated heterogeneous masses with avid peripheral enhancement without... | ['Aged', 'Female', 'Fluorodeoxyglucose F18', 'Humans', 'Lung Neoplasms', 'Meningeal Neoplasms', 'Meningioma', 'Positron-Emission Tomography', 'Radiopharmaceuticals'] | 21,088,084 | [['M01.060.116.100'], ['D09.254.229.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['C04.588.614.250.580', 'C10.551.240.500'], ['C04.557.580.520', 'C04.557.645.520', 'C04.588.614.250.580.500', 'C10.551.240.500.500'], ['E01.370.350.350.800.700', 'E01.370.35... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The role of alpha-methylacyl-CoA racemase in bile acid synthesis. | According to current views, the second peroxisomal beta-oxidation pathway is responsible for the degradation of the side chain of bile acid intermediates. Peroxisomal multifunctional enzyme type 2 [peroxisomal multifunctional 2-enoyl-CoA hydratase/(R)-3-hydroxyacyl-CoA dehydrogenase; MFE-2] catalyses the second (hydrat... | ['3-Hydroxyacyl CoA Dehydrogenases', 'Acyl Coenzyme A', 'Animals', 'Bile Acids and Salts', 'Cholesterol', 'Chromatography, High Pressure Liquid', 'Enoyl-CoA Hydratase', 'Isomerases', 'Models, Chemical', 'Multienzyme Complexes', 'Peroxisomal Bifunctional Enzyme', 'Racemases and Epimerases', 'Rats', 'Stereoisomerism'] | 11,964,182 | [['D08.811.682.047.820.150'], ['D03.633.100.759.646.138.382.300', 'D08.211.211.300', 'D13.695.667.138.382.300', 'D13.695.827.068.382.300'], ['B01.050'], ['D04.210.500.105'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['E05.196.181.400.300'], ['D08.811.520.241.300.250'], ['D08.811.399'], ... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bi-weekly docetaxel in the adjuvant treatment of node-positive or high-risk breast cancer patients: phase I study of the Shiga Breast Cancer Study Group. | BACKGROUND: A phase I study of bi-weekly docetaxel was performed to determine the maximum tolerated dose (MTD) as well as the incidence and severity of toxicities in patients with high-risk node-negative and node-positive breast cancer.METHODS: Docetaxel was administered every 14 days to postoperative breast cancer pat... | ['Adult', 'Aged', 'Antineoplastic Agents', 'Breast Neoplasms', 'Chemotherapy, Adjuvant', 'Docetaxel', 'Drug Administration Schedule', 'Female', 'Humans', 'Japan', 'Lymphatic Metastasis', 'Maximum Tolerated Dose', 'Middle Aged', 'Taxoids'] | 18,493,840 | [['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.248'], ['C04.588.180', 'C17.800.090.500'], ['E02.186.170', 'E02.319.170'], ['D02.455.426.392.368.242.888.389', 'D02.455.849.291.850.389'], ['E02.319.283'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.474.463', 'Z01.639.595'], ['C04.697.650.560', 'C23.5... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
Hydrothorax: an unexpected complication after laparoscopic myomectomy. | We report a case of hydrothorax as a complication of laparoscopic myomectomy in an otherwise healthy woman. The most likely cause of the patient's hydrothorax was irrigation fluid moving from the peritoneal cavity into the pleural space via defects in the diaphragm. Anaesthesists and surgeons should consider hydrothora... | ['Adult', 'Female', 'Humans', 'Hydrothorax', 'Hypoxia', 'Laparoscopy', 'Leiomyoma', 'Uterine Neoplasms'] | 11,517,142 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C08.528.476'], ['C23.888.852.079'], ['E01.370.388.250.520', 'E04.502.250.520'], ['C04.557.450.590.450'], ['C04.588.945.418.948', 'C13.351.500.852.762', 'C13.351.937.418.875']] | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Downregulation of Protein Inhibitor of Activated STAT (PIAS) 1 Is Possibly Involved in the Process of Allograft Rejection. | BACKGROUND: Protein inhibitors of activated STAT (PIAS) proteins are regarded as negative regulators of cytokine-signaling and potent immunosuppressive proteins. However, their role in the process of organ transplant rejection has not been elucidated.METHODS: In the current study, we compared transcript levels of PIAS1... | ['Adult', 'Allografts', 'Down-Regulation', 'Female', 'Graft Rejection', 'Humans', 'Male', 'Middle Aged', 'Protein Inhibitors of Activated STAT', 'Small Ubiquitin-Related Modifier Proteins'] | 31,870,601 | [['M01.060.116'], ['A01.941.500'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['G12.875.545.328'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['D12.644.360.024.319', 'D12.776.157.057.124', 'D12.776.476.024.402'], ['D12.776.947.249']] | ['Named Groups [M]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Molecular organization of the DQ subregion (DO-DX-DV-DQ) of the human MHC and its evolutionary implications. | An overlapping set of cosmid clones from the homozygous DR7 B lymphoblastoid cell line MANN linking the HLA-DO through -DQ subregions is described. This region encompasses 280 kb of DNA, including DQ alpha, DQ beta, DX alpha, DX beta, DO beta, and recently indentified L chain sequences termed DV beta. The orientation a... | ['Biological Evolution', 'Chromosome Mapping', 'Chromosomes, Human, Pair 6', 'Cloning, Molecular', 'Cosmids', 'Genes', 'Genes, Overlapping', 'Genetic Linkage', 'HLA-D Antigens', 'HLA-DQ Antigens', 'Humans'] | 3,411,129 | [['G05.045', 'G16.075'], ['E05.393.183'], ['A11.284.187.520.300.325.330', 'G05.360.162.520.300.325.330'], ['E05.393.220'], ['G05.360.337.500', 'G05.360.600.250'], ['G05.360.340.024.340'], ['G05.360.340.024.340.385'], ['G05.348'], ['D12.776.395.550.509.400', 'D12.776.543.550.440.400', 'D23.050.301.500.400.400', 'D23.050... | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Equine protozoal myeloencephalitis caused by Neospora hughesi in an adult horse in Saskatchewan. | A protozoal parasite identified as Neospora hughesi was found in inflammatory lesions in the central nervous system of a Canadian-born adult horse presented with neurological signs. This is believed to be the first case of equine protozoal myeloencephalitis (EPM) caused by Neospora hughesi in a horse outside of the Uni... | ['Animals', 'Coccidiosis', 'Encephalomyelitis', 'Fatal Outcome', 'Horse Diseases', 'Horses', 'Male', 'Neospora', 'Saskatchewan'] | 19,881,924 | [['B01.050'], ['C01.610.752.250'], ['C01.207.291', 'C10.228.228.291', 'C10.228.440'], ['E05.318.308.985.550.325', 'N01.224.935.698.201', 'N06.850.505.400.975.550.325', 'N06.850.520.308.985.550.325'], ['C22.488'], ['B01.050.150.900.649.313.984.235.472'], ['B01.043.075.189.250.750.550'], ['Z01.107.567.176.858']] | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
A miniaturized Nafion-based glucose sensor: in vitro and in vivo evaluation in dogs. | We have developed an implantable glucose sensor based on a new tri-layer membrane configuration. The needle-type sensor integrates a Pt working electrode and a Ag/AgCl reference electrode. Its size is equivalent to a 25 gauge needle (0.5 mm in diamater). Poly (o-phenylenediamine) was used as an inner coating to reduce ... | ['Animals', 'Biocompatible Materials', 'Biosensing Techniques', 'Blood Glucose', 'Dogs', 'Electrodes, Implanted', 'Fluorocarbon Polymers', 'Glucose Tolerance Test', 'Microelectrodes', 'Monitoring, Physiologic'] | 8,039,946 | [['B01.050'], ['D25.130', 'D27.720.102.130', 'J01.637.051.130'], ['E05.601.043'], ['D09.947.875.359.448.500'], ['B01.050.150.900.649.313.750.250.216.200'], ['E07.305.250.319', 'E07.695.202'], ['D05.750.395', 'D25.720.395', 'J01.637.051.720.395'], ['E01.370.225.124.100.355', 'E01.370.374.355', 'E05.200.124.100.355'], ['... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
[The interview in dental clinical examination: the role of reformulation]. | Faced to the major role of the patients examination as a part of our interventions in dentistry, and with to our pedagogic mission towards students, we propose a method of interviewing the patients based on the principle of reformulation, basic technique in the help-talk. The described experimentation demonstrates the ... | ['Adult', 'Communication', 'Dentist-Patient Relations', 'Female', 'Humans', 'Medical History Taking'] | 2,630,643 | [['M01.060.116'], ['F01.145.209', 'L01.143'], ['F01.829.401.650.410', 'N05.300.660.325'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.510']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Information Science [L]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
[The physician in the dilemma between confidentiality and mandatory reporting of occupational diseases]. | If a physician may reasonably suspect an occupational disease after examining his or her patient he is liable by German law to report this directly to the statutory accident insurance body or the Government institution responsible for the medical safety of working places, in accordance with section 202 of the Federal G... | ['Confidentiality', 'Disease Notification', 'Ethics, Medical', 'Germany', 'Humans', 'Lung Diseases, Obstructive', 'Occupational Diseases'] | 10,028,839 | [['F04.096.544.335.240', 'I01.880.604.473.650.500', 'I01.880.604.583.080', 'N03.706.437.650.124', 'N03.706.535.230'], ['E05.318.362', 'N06.850.520.373', 'N06.850.780.200.262'], ['K01.752.566.479.171.132.750', 'N05.350.340.162.500'], ['Z01.542.315'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C08.381.495'], ['C2... | ['Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Humanities [K]', 'Geographicals [Z]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Characterization of four midgut aminopeptidase N isozymes from Ostrinia furnacalis strains with different susceptibilities to Bacillus thuringiensis. | The full-length cDNA of four Ofapn aminopeptidases were cloned and sequenced from susceptible and resistant Ostrinia furnacalis strains. Four sequences were identified as APN because they shared the common structural features with APN from Lepidoptera, including the signal peptide, GPI anchor signal, the zinc binding/g... | ['Amino Acid Sequence', 'Animals', 'Bacillus thuringiensis', 'CD13 Antigens', 'DNA, Complementary', 'Insect Proteins', 'Insecticide Resistance', 'Isoenzymes', 'Lepidoptera', 'Molecular Sequence Data', 'Pest Control, Biological', 'Reverse Transcriptase Polymerase Chain Reaction'] | 24,269,376 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['B03.300.390.400.158.218.800', 'B03.353.500.100.218.800', 'B03.510.100.100.218.800', 'B03.510.415.400.158.218.800', 'B03.510.460.410.158.218.800'], ['D08.811.277.656.350.100.160', 'D08.811.277.656.350.555.100', 'D08.811.277.656.675.555.100', 'D23.050.301.264.89... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Molecular population genetics of sex determination genes: the transformer gene of Drosophila melanogaster. | The transformer locus (tra) produces an RNA processing protein that alternatively splices the doublesex pre-mRNA in the sex determination hierarchy of Drosophila melanogaster. Comparisons of the tra coding region among Drosophila species have revealed an unusually high degree of divergence in synonymous and nonsynonymo... | ['Animals', 'Base Sequence', 'DNA Primers', 'Drosophila melanogaster', 'Molecular Sequence Data', 'Mutation', 'Polymorphism, Genetic', 'Sex Differentiation'] | 8,013,913 | [['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['B01.050.500.131.617.720.500.500.750.310.250.500'], ['L01.453.245.667'], ['G05.365.590'], ['G05.365.795'], ['G07.345.500.325.377.843', 'G07.345.750.500', 'G08.686.841.500']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Fate of organic matter during moderate heat treatment of sludge: kinetics of biopolymer and hydrolytic activity release and impact on sludge reduction by anaerobic digestion. | Temperature-phased anaerobic digestion with a 50-70 °C pre-treatment is widely proposed for sludge. Here, such a sludge pre-treatment (65 °C) was studied against the physical, enzymatic and biodegradation processes. The soluble and particulate fractions were analysed in terms of biochemical composition and hydrolytic e... | ['Anaerobiosis', 'Biopolymers', 'Bioreactors', 'Hot Temperature', 'Hydrolysis', 'Sewage', 'Waste Disposal, Fluid', 'Water Purification'] | 24,804,656 | [['G02.111.062', 'G03.078'], ['D05.750.078', 'D25.720.099', 'J01.637.051.720.099'], ['E07.115', 'J01.897.120.115'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.775.710.380', 'N06.230.300.100.725.232', 'N06.230.300.100.725.710.380'], ['G02.380'], ['D20.944.932.500'], ['N06.850.780.200.800.800.890', '... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Effects of performance expectancy and self-focused attention on social interaction. | We investigated the impact of performance expectancies and self-focused attention on social performance in a mixed-sex dyad. A group of 48 undergraduate men with self-reported moderate social anxiety were divided into two groups on the basis of their high or low performance expectancies. Subjects were asked to respond ... | ['Attention', 'Attitude', 'Female', 'Humans', 'Interpersonal Relations', 'Male', 'Models, Psychological', 'Self-Assessment', 'Set, Psychology'] | 3,723,336 | [['F02.830.104.214'], ['F01.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.401'], ['E05.599.695'], ['F01.752.747.792.537'], ['F02.463.425.838']] | ['Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Child abuse and autonomic nervous system hyporesponsivity among psychiatrically impaired children. | OBJECTIVE: Sexually or physically abused children are at risk for neurobiological dysregulation as well as for internalizing and disruptive behavior disorders. Stress-related autonomic nervous system (ANS) down-regulation has been proposed as a sequela of abuse and was investigated in the present study.METHODS: Child P... | ['Adolescent', 'Autonomic Nervous System', 'Child', 'Child Abuse', 'Child Abuse, Sexual', 'Diagnosis, Differential', 'Female', 'Humans', 'Logistic Models', 'Male', 'Mental Disorders', 'Prevalence'] | 20,605,634 | [['M01.060.057'], ['A08.800.050'], ['M01.060.406'], ['I01.198.240.856.350.250', 'I01.880.735.900.350.250'], ['I01.198.240.748.300', 'I01.198.240.856.350.250.255', 'I01.880.735.900.350.250.255'], ['E01.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.525', 'E05.318.740.600.800.450', 'E05.318.740... | ['Named Groups [M]', 'Anatomy [A]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Timing and risks of chemoprophylaxis after spinal surgery: a single-center experience with 6869 consecutive patients. | OBJECTIVE Venous thromboembolism (VTE) after spinal surgery is a major cause of morbidity, but chemoprophylactic anticoagulation can prevent it. However, there is variability in the timing and use of chemoprophylactic anticoagulation after spine surgery, particularly given surgeons' concerns for spinal epidural hematom... | ['Adult', 'Aged', 'Anticoagulants', 'Chemoprevention', 'Female', 'Hematoma, Epidural, Spinal', 'Humans', 'Incidence', 'Male', 'Middle Aged', 'Neurosurgical Procedures', 'Postoperative Complications', 'Pulmonary Embolism', 'Retrospective Studies', 'Risk', 'Risk Factors', 'Spinal Cord', 'Venous Thromboembolism', 'Venous ... | 28,885,127 | [['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.502.119'], ['E02.319.162'], ['C23.550.414.838.355'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.985.525.375'], ['M01.060.116.630'], ['E04.525'], ['C23.550.767'], ... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Separation optimization of aniline and seven 4-substituted anilines in high-submicellar liquid chromatography using empirical retention modeling and Derringer's desirability function. | The separation optimization of aniline and seven 4-substituted derivatives in high-submicellar LC was performed using an interpretive optimization strategy and Derringer's desirability function. Description of the retention of solutes was carried out through several hyperbolic and logarithmic retention models using the... | ['Aniline Compounds', 'Chromatography, High Pressure Liquid', 'Models, Molecular', 'Software'] | 23,716,348 | [['D02.092.146'], ['E05.196.181.400.300'], ['E05.599.595'], ['L01.224.900']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Attenuation of the osmotic release of vasopressin by enkephalins in dogs. | To assess the possible role of circulating enkephalins in the osmotic release of vasopressin, Met5 (M-Enk)- or Leu5-enkephalin (L-Enk) dissolved in 0.9 or 10% NaCl was infused to either anesthetized or conscious dogs at a dose of 3.5 nM.kg-1.min-1 for 15 min. Intravenous infusion of M-Enk or L-Enk produced 150- to 200-... | ['Animals', 'Arginine Vasopressin', 'Blood Pressure', 'Dogs', 'Enkephalin, Leucine', 'Enkephalin, Methionine', 'Female', 'Heart Rate', 'Infusions, Intravenous', 'Kinetics', 'Male', 'Osmolar Concentration', 'Potassium', 'Reference Values', 'Sodium'] | 2,919,668 | [['B01.050'], ['D06.472.699.631.692.781.100', 'D12.644.400.900.100', 'D12.644.456.925.100', 'D12.644.548.691.692.781.100', 'D12.776.631.650.937.100'], ['E01.370.600.875.249', 'G09.330.380.076'], ['B01.050.150.900.649.313.750.250.216.200'], ['D12.644.400.575.281.231', 'D12.776.631.650.575.281.231'], ['D12.644.400.575.28... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The urban context: a place to eliminate health disparities and build organizational capacity. | This study seeks to examine the process of building the capacity to address health disparities in several urban African American neighborhoods. An inter-organizational network consisting of a research university, community members, community organizations, media partners, and foundations was formed to develop a communi... | ['African Americans', 'Capacity Building', 'Community Networks', 'Health Status Disparities', 'Humans', 'Interviews as Topic', 'Organizational Case Studies', 'Pennsylvania', 'Urban Population'] | 21,271,434 | [['M01.686.508.100.100', 'M01.686.754.100'], ['N02.138', 'N04.452.105'], ['I01.880.853.500.300', 'L01.313.500.750.300.184', 'N02.421.143.202'], ['I01.240.425.675', 'N01.224.425.437', 'N06.850.505.400.425.675'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.420', 'L01.399.250.520', 'N05.715.360.300.400'... | ['Named Groups [M]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
Preparation, characterization, and FET properties of novel dicyanopyrazinoquinoxaline derivatives. | [structure: see text] A series of the title dicyanopyrazinoquinoxaline derivatives have been prepared and characterized by using single-crystal X-ray structure analysis and redox potential measurements. They have strong electron-accepting properties due to the pyrazinopyrazine skeletons as well as the cyano groups. Sub... | ['Models, Chemical', 'Molecular Structure', 'Nitriles', 'Pyrazines', 'Quinoxalines'] | 15,176,805 | [['E05.599.495'], ['G02.111.570', 'G02.466'], ['D02.626'], ['D03.383.679'], ['D03.633.100.857']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
HGF induces epithelial-to-mesenchymal transition by modulating the mammalian hippo/MST2 and ISG15 pathways. | Epithelial to mesenchymal transition (EMT) is a fundamental cell differentiation/dedifferentiation process which is associated with dramatic morphological changes. Formerly polarized and immobile epithelial cells which form cell junctions and cobblestone-like cell sheets undergo a transition into highly motile, elongat... | ['Animals', 'Cadherins', 'Cell Adhesion', 'Dogs', 'Epithelial-Mesenchymal Transition', 'Hepatocyte Growth Factor', 'Integrins', 'Madin Darby Canine Kidney Cells', 'Protein-Serine-Threonine Kinases', 'Proteome', 'Signal Transduction', 'Ubiquitin-Protein Ligases', 'Ubiquitination', 'Ubiquitins'] | 24,766,643 | [['B01.050'], ['D12.776.395.550.200.200', 'D12.776.543.550.200.200', 'D23.050.301.350.200'], ['G04.022'], ['B01.050.150.900.649.313.750.250.216.200'], ['G04.356.500'], ['D12.644.276.374.420', 'D12.776.467.374.420', 'D23.529.374.420'], ['D12.776.543.750.705.408'], ['A11.251.210.827', 'A11.436.589'], ['D08.811.913.696.62... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Passive immunization with monoclonal antibodies against Porphyromonas gingivalis in patients with periodontitis. | Selective inhibition of recolonization of Porphyromonas gingivalis was investigated by topical application of monoclonal antibody (MAb). To select a MAb to P. gingivalis with the potential for recognizing most strains of P. gingivalis, we examined seven MAbs, one of which (MAb 61BG 1.3) recognized all 22 laboratory str... | ['Adult', 'Aged', 'Aged, 80 and over', 'Antibodies, Bacterial', 'Antibodies, Monoclonal', 'Dental Plaque', 'Double-Blind Method', 'Humans', 'Immunization, Passive', 'Middle Aged', 'Periodontitis', 'Porphyromonas gingivalis'] | 8,550,186 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D12.776.124.486.485.114.107', 'D12.776.124.790.651.114.125', 'D12.776.377.715.548.114.125'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['C07.793.208.377'], ['E05.318.370.300', 'E05.581.500.300', 'N05.7... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
SGK-1 protects kidney cells against apoptosis induced by ceramide and TNF-á. | Ceramide regulates several different cellular responses including mechanisms leading to apoptosis. Serum- and glucocorticoid-inducible protein kinase (SGK)-1 is a serine threonine kinase, which activates survival pathways in response to stress stimuli. Recently, we demonstrated an anti-apoptotic role of SGK-1 in human ... | ['Apoptosis', 'Ceramides', 'HEK293 Cells', 'Humans', 'Immediate-Early Proteins', 'Kidney', 'Protein-Serine-Threonine Kinases', 'Transfection', 'Tumor Necrosis Factor-alpha'] | 26,379,195 | [['G04.146.954.035'], ['D02.065.313', 'D09.400.410.420.525.200', 'D10.390.470.675.200', 'D10.570.877.360.612.200'], ['A11.251.210.172.750', 'A11.436.334'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.460', 'D12.776.964.925.968'], ['A05.810.453'], ['D08.811.913.696.620.682.700'], ['E05.393.350.810', 'G05.... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Adenomatoid tumours: a mucin histochemical and immunohistochemical study. | We have examined 16 cases of adenomatoid tumour using a panel of monoclonal and polyclonal antibodies and also stained them for the presence of hyaluronidase-sensitive alcianophilic material. Fourteen cases expressed cytokeratins and a proportion of these also expressed S-100 protein, neuron-specific enolase, vimentin,... | ['Female', 'Humans', 'Immunoenzyme Techniques', 'Male', 'Mesothelioma', 'Staining and Labeling'] | 1,371,104 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.478.566.350', 'E05.478.583.400', 'E05.601.470.350'], ['C04.557.470.035.510', 'C04.557.470.660.510'], ['E01.370.225.500.620.670', 'E01.370.225.750.600.670', 'E05.200.500.620.670', 'E05.200.750.600.670']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Effect of TUBB3, TS and ERCC1 mRNA expression on chemoresponse and clinical outcome of advanced gastric cancer by multiplex branched-DNA liquid chip technology]. | OBJECTIVE: To analyze the impact of â-tubulin-III (TUBB3), thymidylate synthase (TS) and excision repair cross complementation group 1 (ERCC1) mRNA expression on chemoresponse and clinical outcome of patients with advanced gastric cancer treated with TXT/CDDP/FU (DCF) regimen chemotherapy.METHODS: The study population ... | ['Antineoplastic Combined Chemotherapy Protocols', 'Biomarkers, Tumor', 'DNA-Binding Proteins', 'Drug Resistance, Neoplasm', 'Endonucleases', 'Humans', 'RNA, Messenger', 'Stomach Neoplasms', 'Thymidylate Synthase', 'Treatment Outcome', 'Tubulin'] | 23,828,702 | [['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['D23.101.140'], ['D12.776.260'], ['G07.690.773.984.395'], ['D08.811.277.352.355'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D13.444.735.544'], ['C04.588.274.476.767', 'C06.301.371.767', 'C06.405.249.767', 'C06.405.748.789'], ['D08.811.913.555.500.86... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Colorectal endometriosis: aggressive surgical management and practical considerations in a patient with advanced disease. | The aim of this study was to evaluate the results of bowel resection in a patient with obstructive colorectal endometriosis. The presentation will acquaint the physician with the signs and symptoms, evaluation, and surgical treatment of colorectal endometriosis. We emphasize that our findings strongly support an aggres... | ['Adult', 'Colonic Diseases', 'Disease Progression', 'Endometriosis', 'Female', 'Humans', 'Rectal Diseases'] | 11,723,904 | [['M01.060.116'], ['C06.405.469.158'], ['C23.550.291.656'], ['C13.351.500.163'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C06.405.469.860']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Isolated thyrotropin deficiency secondary to primary empty sella in a patient with differentiated thyroid carcinoma: an indication for recombinant thyrotropin. | The primary empty sella syndrome is a common radiographic finding that is rarely associated with clinical pituitary dysfunction. Studies using dynamic endocrine testing, however, have shown altered pituitary reserve in some patients with the primary empty sella syndrome. We describe a patient with a primary empty sella... | ['Carcinoma, Papillary', 'Combined Modality Therapy', 'Empty Sella Syndrome', 'Female', 'Humans', 'Iodine Radioisotopes', 'Magnetic Resonance Imaging', 'Middle Aged', 'Recombinant Proteins', 'Thyroid Neoplasms', 'Thyrotropin'] | 10,646,666 | [['C04.557.470.200.360', 'C04.557.470.700.360'], ['E02.186'], ['C10.228.140.617.738.200', 'C19.700.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.268.380.400.500.496', 'D01.496.448.496', 'D01.496.749.474'], ['E01.370.350.825.500'], ['M01.060.116.630'], ['D12.776.828'], ['C04.588.322.894', 'C04.588.443.91... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The sensitivity of metabolomics versus classical regulatory toxicology from a NOAEL perspective. | The identification of the no observed adverse effect level (NOAEL) is the key regulatory outcome of toxicity studies. With the introduction of "omics" technologies into toxicological research, the question arises as to how sensitive these technologies are relative to classical regulatory toxicity parameters. BASF SE an... | ['Agrochemicals', 'Animals', 'Databases, Chemical', 'Drug Evaluation, Preclinical', 'Drugs, Investigational', 'Female', 'Germany', 'Guidelines as Topic', 'Humans', 'Legislation, Drug', 'Male', 'Metabolomics', 'Models, Biological', 'No-Observed-Adverse-Effect Level', 'Nonprescription Drugs', 'Prescription Drugs', 'Rats'... | 24,657,160 | [['D27.720.031'], ['B01.050'], ['L01.313.500.750.300.188.400.300', 'L01.470.750.750.300'], ['E05.290.750', 'E05.337.550'], ['D26.371'], ['Z01.542.315'], ['N04.761.700.350', 'N05.700.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I01.880.604.605', 'N03.706.615.402'], ['H01.158.201.586', 'H01.158.273.180.599',... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 |
[Synthesis of catechol aminoketone and its analogues]. | In this paper, the synthesis of a series of aminoketone derivatives are reported. Compounds I1-9 and II1-10 were synthesized from substituted chloroacetophenone with various amines. Compounds I10-12 and II11-12 were synthesized from substituted acetophenones with corresponding amines through Mannich reaction. The 1HNMR... | ['Animals', 'Arrhythmias, Cardiac', 'Chemical Phenomena', 'Chemistry', 'Coronary Circulation', 'Dogs', 'Muscle Contraction', 'Muscle, Smooth, Vascular', 'Myocardial Contraction', 'Norepinephrine'] | 2,239,316 | [['B01.050'], ['C14.280.067', 'C23.550.073'], ['G02'], ['H01.181'], ['G09.330.100.324'], ['B01.050.150.900.649.313.750.250.216.200'], ['G11.427.494'], ['A02.633.570.491', 'A07.015.733.500', 'A10.690.467.491'], ['G09.330.580', 'G11.427.494.570'], ['D02.033.100.291.502', 'D02.092.063.480', 'D02.092.211.215.746', 'D02.092... | ['Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Early markers of renal dysfunction in patients with sickle cell/beta-thalassemia. | Progressive renal failure is one of the main complications in HbS/beta-thalassemia (HbS/beta-thal). Early identification of patients at high risk of developing renal failure is of great importance as it may allow specific measures to delay the progression of renal damage and thus reduce the incidence of end-stage renal... | ['Acetylglucosaminidase', 'Adult', 'Anemia, Sickle Cell', 'Biomarkers', 'Cystatin C', 'Cystatins', 'Disease Progression', 'Female', 'Humans', 'Kidney Diseases', 'Male', 'Time Factors', 'beta 2-Microglobulin', 'beta-Thalassemia'] | 16,501,491 | [['D08.811.277.450.483.180.500'], ['M01.060.116'], ['C15.378.071.141.150.150', 'C15.378.420.155', 'C16.320.070.150', 'C16.320.365.155'], ['D23.101'], ['D12.776.215.300'], ['D12.776.215'], ['C23.550.291.656'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.777.419', 'C13.351.968.419'], ['G01.910.857'], ['D12.776... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Subclinical hypothyroidism in combination with vitamin D deficiency increases the risk of impaired left ventricular diastolic function. | OBJECTIVE: Subclinical hypothyroidism and vitamin D deficiency are common. The diastolic function of patients with both subclinical hypothyroidism and vitamin D deficiency remains unknown. This study aimed to investigate diastolic dysfunction in patients with both subclinical hypothyroidism and vitamin D deficiency.SUB... | ['Adult', 'Asymptomatic Diseases', 'Cohort Studies', 'Cross-Sectional Studies', 'Echocardiography, Doppler', 'Female', 'Humans', 'Hypothyroidism', 'Male', 'Middle Aged', 'Risk Factors', 'Ventricular Dysfunction, Left', 'Ventricular Function, Left', 'Vitamin D Deficiency'] | 25,960,009 | [['M01.060.116'], ['C23.550.291.187'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['E01.370.350.130.750.220', 'E01.370.350.850.220.220', 'E01.370.350.850.850.220', 'E01.370.370.380.220.220'], ['B01.050.150... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Immunohistochemical investigations on the ontogenesis of the subcommissural organ]. | Using an antiserum raised against bovine Reissner's fiber a ventricle border of the matrix epithel reacting in the immunohistochemical procedure according to Sternberger et al. (1970) is visible in the very early stage of the embryonic brain of Pleurodeles waltli. In the basal region of the brain the immunoreactive bor... | ['Animals', 'Embryo, Nonmammalian', 'Embryonic and Fetal Development', 'Female', 'Neurosecretory Systems', 'Pleurodeles', 'Pregnancy', 'Subcommissural Organ'] | 3,090,635 | [['B01.050'], ['A13.350', 'A16.331'], ['G07.345.500.325', 'G08.686.784.170'], ['A06.688', 'A08.713'], ['B01.050.150.900.090.608.700.540'], ['G08.686.784.769'], ['A06.688.178.937', 'A08.186.211.132.659.800.713', 'A08.713.049.937']] | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Alterations in the concentrations of liver mitochondrial DNA, cytoplasmic total hydrocarbon and calcium in Guinea pigs after treatment with Nigerian light crude oil. | The alteration of cellular calcium sequestration has been postulated to be a primary mechanism in the initiation of irreversible cell damage. Crude oil has been shown to cause concentration- dependent inhibition of calcium influx and mitochondrial swelling which may relate to its toxicity. Nigerian 'Bonny' Light Crude ... | ['Animals', 'Calcium', 'Cytoplasm', 'DNA, Mitochondrial', 'Dose-Response Relationship, Drug', 'Guinea Pigs', 'Hydrocarbons', 'Male', 'Mitochondria, Liver', 'Nigeria', 'Petroleum', 'Toxicity Tests'] | 17,431,311 | [['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['A11.284.430.214'], ['D13.444.308.283.225'], ['G07.690.773.875', 'G07.690.936.500'], ['B01.050.150.900.649.313.992.550'], ['D02.455'], ['A11.284.430.214.190.875.564.461', 'A11.284.835.626.461'], ['Z01.058.290.190.565'], ['D20.345.630', 'N06.230.132.2... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Sodium bicarbonate therapy for patients with severe metabolic acidaemia in the intensive care unit (BICAR-ICU): a multicentre, open-label, randomised controlled, phase 3 trial. | BACKGROUND: Acute acidaemia is frequently observed during critical illness. Sodium bicarbonate infusion for the treatment of severe metabolic acidaemia is a possible treatment option but remains controversial, as no studies to date have examined its effect on clinical outcomes. Therefore, we aimed to evaluate whether s... | ['Acidosis', 'Cohort Studies', 'Humans', 'Hydrogen-Ion Concentration', 'Infusions, Intravenous', 'Intensive Care Units', 'Renal Replacement Therapy', 'Sodium Bicarbonate', 'Survival Analysis'] | 29,910,040 | [['C18.452.076.176'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.300'], ['E02.319.267.082.500', 'E02.319.267.510.590'], ['N02.278.388.493'], ['E02.870'], ['D01.200.275.150.100.800', 'D01.857.625'], ['E05.318.740.998', 'N05.715.36... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Highly effective inhibition of lung cancer growth and metastasis by systemic delivery of siRNA via multimodal mesoporous silica-based nanocarrier. | Lung cancer has been the leading type of cancers with regard to mortality and mobility. New versions of RNAi-based therapy are greatly required to tackle the challenges of lung cancer. In this study, we developed a novel siRNA delivery vector based on our magnetic mesoporous silica nanoparticles (M-MSNs) platform. This... | ['Animals', 'Cell Line, Tumor', 'Cell Proliferation', 'Diffusion', 'Genetic Therapy', 'Humans', 'Mice', 'Mice, Nude', 'Nanocapsules', 'Nanopores', 'Neoplasms, Experimental', 'Porosity', 'RNA, Small Interfering', 'Transfection', 'Treatment Outcome', 'Vascular Endothelial Growth Factor A'] | 25,277,774 | [['B01.050'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.161.750', 'G07.345.249.410.750'], ['G01.202', 'G02.196'], ['E02.095.301', 'E05.393.420.301'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.150.900.649.313.992.635.505.500.550.500'], ['D26.255.260.575',... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Apolipoprotein J (clusterin) induces cholesterol export from macrophage-foam cells: a potential anti-atherogenic function? | Apolipoprotein J (apo J) is a secreted glycoprotein of which the exact function remains a matter for speculation. Apo J has been implicated in such diverse processes as sperm maturation, regulation of complement activation, programmed cell death, tissue remodelling and lipid transport. In this study a possible role for... | ['Animals', 'Arteriosclerosis', 'Biological Transport', 'Cells, Cultured', 'Cholesterol', 'Clusterin', 'Dose-Response Relationship, Drug', 'Foam Cells', 'Glycoproteins', 'Humans', 'Macrophages, Peritoneal', 'Mice', 'Molecular Chaperones'] | 9,512,484 | [['B01.050'], ['C14.907.137.126'], ['G03.143'], ['A11.251'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['D12.776.395.207', 'D12.776.580.215'], ['G07.690.773.875', 'G07.690.936.500'], ['A11.329.372.368', 'A11.627.482.368', 'A11.733.397.368', 'A15.382.670.522.368', 'A15.382.680.397.368'],... | ['Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Clinical and Radiographic Results of Attune and PFC Sigma Knee Designs at 2-Year Follow-Up: A Prospective Matched-Pair Analysis. | BACKGROUND: Anterior knee pain (AKP) and/or crepitation are important causes of dissatisfaction after total knee arthroplasty (TKA). Aim of this prospective, matched-pair study was to compare 2 different designs of patellofemoral (ie, trochlear groove) TKA. The Attune knee has an anatomic trochlear groove with a medial... | ['Aged', 'Arthroplasty, Replacement, Knee', 'Female', 'Follow-Up Studies', 'Humans', 'Knee Joint', 'Knee Prosthesis', 'Male', 'Matched-Pair Analysis', 'Middle Aged', 'Models, Statistical', 'Patella', 'Patient Satisfaction', 'Prospective Studies', 'Psychometrics', 'Range of Motion, Articular'] | 27,600,300 | [['M01.060.116.100'], ['E04.555.110.110.115', 'E04.650.110.115', 'E04.680.101.110.115'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.583.475'], ['E07.695.400.410'], ['E05.318.370.485', 'E05.318.740.475', 'N05.715.3... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Outcome of meningitis among children less than 2-y-old in Haryana. | Incidence of neurological complications and disability following meningitis among children less than 2 y in a community setting in Haryana was assessed. Cases were enrolled from hospitals of in Yamunanagar district. They were first assessed for disability or neurological complications at their home by health workers 1 ... | ['Disability Evaluation', 'Disabled Children', 'Female', 'Humans', 'India', 'Infant', 'Infant, Newborn', 'Male', 'Meningitis', 'Nervous System Diseases', 'Prevalence', 'Surveys and Questionnaires', 'Survival Rate'] | 22,528,695 | [['E01.370.400'], ['M01.150.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.245.393'], ['M01.060.703'], ['M01.060.703.520'], ['C10.228.614'], ['C10'], ['E05.318.308.985.525.750', 'N01.224.935.597.750', 'N06.850.505.400.975.525.750', 'N06.850.520.308.985.525.750'], ['E05.318.308.980', 'N05.715.360.300.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Organisms [B]', 'Geographicals [Z]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Down-regulation of DNA topoisomerase IIalpha in human colorectal carcinoma cells resistant to a protoberberine alkaloid, berberrubine. | Berberrubine, a protoberberine alkaloid that exhibits antitumor activity in animal models, has been identified as a specific poison of DNA topoisomerase II in vitro. To better understand the mechanisms of cellular response to berberrubine, human colorectal carcinoma cells (AMC5) were selected for resistance to berberru... | ['Alkaloids', 'Antigens, Neoplasm', 'Antineoplastic Agents', 'Berberine', 'Colorectal Neoplasms', 'DNA Topoisomerases, Type II', 'DNA-Binding Proteins', 'Down-Regulation', 'Doxorubicin', 'Drug Resistance, Neoplasm', 'Drug Screening Assays, Antitumor', 'Half-Life', 'Humans', 'Promoter Regions, Genetic', 'RNA, Messenger'... | 11,901,227 | [['D03.132'], ['D23.050.285'], ['D27.505.954.248'], ['D03.132.098.057.100', 'D03.633.400.168.100'], ['C04.588.274.476.411.307', 'C06.301.371.411.307', 'C06.405.249.411.307', 'C06.405.469.158.356', 'C06.405.469.491.307', 'C06.405.469.860.180'], ['D08.811.399.403.741'], ['D12.776.260'], ['G02.111.240', 'G05.308.200', 'G0... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Health equity in humanitarian emergencies: a role for evidence aid. | Humanitarian emergencies require a range of planned and coordinated actions: security, healthcare, and, as this article highlights, health equity responses. Health equity is an evidence-based science that aims to address unfair and unjust health inequality outcomes. New approaches are using health equity to guide the d... | ['Altruism', 'Disasters', 'Emergencies', 'Evidence-Based Medicine', 'Global Health', 'Health Equity', 'Health Status Disparities', 'Healthcare Disparities', 'Humans'] | 25,594,783 | [['F01.145.813.090'], ['N06.230.100'], ['C23.550.291.781', 'N06.230.100.083', 'N06.850.376'], ['H02.249.750', 'H02.403.200.400'], ['H02.403.371', 'N01.400.337'], ['N04.590.374.350.500', 'N05.300.430.383'], ['I01.240.425.675', 'N01.224.425.437', 'N06.850.505.400.425.675'], ['N04.590.374.380', 'N05.300.493'], ['B01.050.1... | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Diseases [C]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 |
Validation of a novel HPLC sorbent material for the determination of ten quinolones in human and veterinary pharmaceutical formulations. | A novel sorbent material of ultrapure silica gel provided with novel State of the Art Bonding- and Endcapping Technology commercially available under the name PerfectSil Target (250 x 4 mm, ODS-3, 5 microm, by MZ-Analysentechnik, Germany) was used and validated for the sensitive HPLC determination of ten quinolone anti... | ['Absorption', 'Animals', 'Anti-Bacterial Agents', 'Chemistry, Pharmaceutical', 'Chromatography, High Pressure Liquid', 'Humans', 'Models, Chemical', 'Quinolones', 'Reproducibility of Results', 'Solutions', 'Tablets', 'Time Factors', 'Veterinary Drugs'] | 16,405,173 | [['G01.015', 'G02.010', 'G03.015', 'G03.787.024', 'G07.690.725.015'], ['B01.050'], ['D27.505.954.122.085'], ['H01.158.703.007', 'H01.181.466'], ['E05.196.181.400.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.495'], ['D03.633.100.810.835'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
[Role of Candida allergen in atopic dermatitis and efficacy of oral therapy with various antifungal agents]. | We studied whether fungal allergens play a role in exacerbating the clinical symptoms of atopic dermatitis (AD). We found that the percentage of the patients who showed CAP-RAST positive (2 < or = score) to Candida albicans (Ca) was significantly higher in the patients with severe symptoms and high serum IgE level than... | ['Administration, Oral', 'Adult', 'Allergens', 'Amphotericin B', 'Antifungal Agents', 'Antigens, Fungal', 'Candida albicans', 'Dermatitis, Atopic', 'Female', 'Fluconazole', 'Humans', 'Itraconazole', 'Male', 'Nystatin'] | 10,481,356 | [['E02.319.267.100'], ['M01.060.116'], ['D23.050.063'], ['D02.540.576.500.500'], ['D27.505.954.122.136'], ['D23.050.202'], ['B01.300.107.795.095.326', 'B01.300.381.147.326', 'B01.300.930.176.326'], ['C16.320.850.210', 'C17.800.174.193', 'C17.800.815.193', 'C17.800.827.210', 'C20.543.480.343'], ['D03.383.129.799.450'], ... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
From asps to allegations: biological warfare in history. | Biological warfare has been waged intermittently for nearly 2,500 years. The techniques of delivery and weaponization of biological warfare agents have gradually evolved from the catapulting of plague victims to the deliberate use of infected clothes, insect vectors, and specialized weapon systems. Despite advances in ... | ['Animals', 'Biological Warfare', 'Disease Vectors', 'History, 15th Century', 'History, 17th Century', 'History, 18th Century', 'History, 19th Century', 'History, 20th Century', 'History, Ancient', 'History, Medieval', 'Humans', 'Military Personnel'] | 8,524,458 | [['B01.050'], ['I01.880.735.950.500.226'], ['N06.850.335.188', 'N06.850.520.203.375'], ['K01.400.475.500'], ['K01.400.504.750'], ['K01.400.504.875'], ['K01.400.504.937'], ['K01.400.504.968'], ['K01.400.470'], ['K01.400.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.526.625']] | ['Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Humanities [K]', 'Named Groups [M]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Basic fibroblast growth factor inhibits ventricular remodeling in Dahl salt-sensitive hypertensive rats. | OBJECTIVE: Basic fibroblast growth factor (bFGF) inhibits the progression of ventricular remodeling in ischemic and hypertensive heart diseases (HHDs). Recent studies have revealed that bFGF induces the transition from myofibroblasts to fibroblasts with decreased expression of alpha-smooth muscle actin (alpha-SMA). To ... | ['Actins', 'Animals', 'Blood Pressure', 'Cardiovascular Diseases', 'Disease Models, Animal', 'Dose-Response Relationship, Drug', 'Fibroblast Growth Factor 2', 'Fibrosis', 'Heart Ventricles', 'Hypertension', 'Male', 'Matrix Metalloproteinase 9', 'Neovascularization, Physiologic', 'Procollagen-Proline Dioxygenase', 'Rats... | 19,008,723 | [['D05.750.078.730.250', 'D12.776.210.500.100', 'D12.776.220.525.255'], ['B01.050'], ['E01.370.600.875.249', 'G09.330.380.076'], ['C14'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['G07.690.773.875', 'G07.690.936.500'], ['D12.644.276.624.120', 'D12.776.467.624.120', 'D23.529.624.120'], ['C23.550.355'], ['A07.541.5... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Ionophore A-23187- and thrombin-induced platelet aggregation: independence from cycloxygenase products. | Stimulation of platelets labeled with [14C]-arachidonate by ionophore A23187 or thrombin produces rapid degradation of specific membrane phospholipids. This is also reflected by the release of [14C]archidonate, which is immediately transformed into products of the cycloxygenase and lipoxygenase enzyme systems, and by i... | ['Animals', 'Anti-Bacterial Agents', 'Arachidonic Acids', 'Calcimycin', 'Cyclic AMP', 'In Vitro Techniques', 'Indomethacin', 'Platelet Aggregation', 'Thrombin'] | 204,935 | [['B01.050'], ['D27.505.954.122.085'], ['D10.251.355.255.100', 'D10.251.355.310.166'], ['D03.633.100.221.173'], ['D03.633.100.759.646.138.395', 'D13.695.462.200', 'D13.695.667.138.395', 'D13.695.827.068.395'], ['E05.481'], ['D03.633.100.473.420'], ['G09.188.370.687', 'G09.188.390.600.640'], ['D08.811.277.656.300.760.85... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Public health and high volume hydraulic fracturing. | High-volume horizontal hydraulic fracturing (HVHF) in unconventional gas reserves has vastly increased the potential for domestic natural gas production. HVHF has been promoted as a way to decrease dependence on foreign energy sources, replace dirtier energy sources like coal, and generate economic development. At the ... | ['Air Pollution', 'Climate Change', 'Extraction and Processing Industry', 'Natural Gas', 'Public Health', 'Quality of Life', 'Risk Management', 'United States', 'Water Pollution'] | 23,552,646 | [['N06.850.460.100'], ['G16.500.175.374'], ['J01.576.655.875'], ['D20.345.369', 'N06.230.132.258.369'], ['H02.403.720', 'N01.400.550', 'N06.850'], ['I01.800', 'K01.752.400.750', 'N06.850.505.400.425.837'], ['N03.219.463.800', 'N04.452.871'], ['Z01.107.567.875'], ['N06.850.460.790']] | ['Health Care [N]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Geographicals [Z]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 |
Cytotoxicity of adenovirus-antibody aggregates: sensitivity to different cell strains, and inhibition by hexon antiserum and by complement. | Adenovirus-antibody aggregates under defined conditions are cytotoxic in vitro. All members of adenovirus groups I, II, and III caused toxicity upon aggregation. The toxicity of the clusters is exerted by the virions. Toxicity is temperature dependent and may be caused by a mechanism similar to that used in viral penet... | ['Adenoviridae', 'Animals', 'Antigen-Antibody Complex', 'Antigens, Viral', 'Caniformia', 'Carnivora', 'Cells, Cultured', 'Chromium Isotopes', 'Complement System Proteins', 'Culture Techniques', 'Cytotoxicity Tests, Immunologic', 'Erythrocytes', 'Guinea Pigs', 'HeLa Cells', 'Humans', 'Immune Sera', 'Immunoglobulin G', '... | 4,737,643 | [['B04.280.030'], ['B01.050'], ['D12.776.124.486.485.114.257', 'D12.776.124.790.651.114.257', 'D12.776.377.715.548.114.257', 'D23.050.101'], ['D23.050.327'], ['B01.050.150.900.649.313.750.250'], ['B01.050.150.900.649.313.750'], ['A11.251'], ['D01.268.556.175.500', 'D01.268.956.124.500', 'D01.496.212', 'D01.552.544.175.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Fault detection for control of wastewater treatment plants. | Interest in real-time model-based control is increasing as more and more facilities are being asked to meet stricter effluent requirements while at the same time minimizing costs. It has been identified that biological process models and automated process control technologies are being used at wastewater treatments pla... | ['Equipment Failure Analysis', 'Online Systems', 'Waste Disposal, Fluid'] | 16,722,089 | [['E05.325.192'], ['L01.313.500.750.300.742'], ['N06.850.780.200.800.800.890', 'N06.850.860.510.900.600.900']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]'] | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
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