Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Characterization of endothelium-derived relaxing factor involvement in the potentiating effect of parathyroidectomy on norepinephrine-induced rat aortic contraction. | Previous results have shown that the contractile response to norepinephrine (NE) was enhanced in isolated aortae from SHR and normotensive Wistar parathyroidectomized rats. In this work we sought to characterize the contribution of endothelium-derived relaxing factor (EDRF) release to this effect which is not linked to... | ['Acetylcholine', 'Animals', 'Aorta', 'Arginine', 'Calcimycin', 'Dose-Response Relationship, Drug', 'Drug Interactions', 'Hemoglobins', 'Male', 'Muscle Contraction', 'Muscle, Smooth, Vascular', 'NG-Nitroarginine Methyl Ester', 'Nitric Oxide', 'Norepinephrine', 'Parathyroidectomy', 'Potassium Chloride', 'Rats', 'Rats, W... | 8,181,795 | [['D02.092.211.111'], ['B01.050'], ['A07.015.114.056'], ['D12.125.068.050', 'D12.125.095.104', 'D12.125.142.087'], ['D03.633.100.221.173'], ['G07.690.773.875', 'G07.690.936.500'], ['G07.690.773.968'], ['D12.776.124.400', 'D12.776.422.316.762'], ['G11.427.494'], ['A02.633.570.491', 'A07.015.733.500', 'A10.690.467.491'],... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Preoperative x-ray computed tomography in cancer of the kidney]. | The authors emphasise the importance of computed tomography in the detection, diagnosis and pre-treatment staging of cancer of the kidney. In a series of 82 cases, the diagnosis was made on the basis of ultrasonography combined with computed tomography in 55% of their last 44 cases. They stress the decreasing value of ... | ['Humans', 'Kidney Neoplasms', 'Lymphatic Metastasis', 'Neoplasm Staging', 'Tomography, X-Ray Computed'] | 6,520,411 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.945.947.535', 'C12.758.820.750', 'C12.777.419.473', 'C13.351.937.820.535', 'C13.351.968.419.473'], ['C04.697.650.560', 'C23.550.727.650.560'], ['E01.789.625'], ['E01.370.350.350.810', 'E01.370.350.600.350.700.810', 'E01.370.350.700.700.810', 'E01.370.350.700.8... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effect of shear stress on platelet adhesion to expanded polytetrafluoroethylene, a silicone sheet, and an endothelial cell monolayer. | We visualized in real-time platelets adhering to the surface of three representative biomaterials, by using an apparatus consisting of a modified cone and plate rheometer combined with an upright epifluorescence microscope under two shear flows (0.1 and 5.0 dyne/cm2). The materials were expanded polytetrafluoroethylene... | ['Animals', 'Biocompatible Materials', 'Cattle', 'Cells, Cultured', 'Endothelium, Vascular', 'Hemorheology', 'In Vitro Techniques', 'Materials Testing', 'Platelet Adhesiveness', 'Polytetrafluoroethylene', 'Rabbits', 'Silicones', 'Stress, Mechanical'] | 11,110,266 | [['B01.050'], ['D25.130', 'D27.720.102.130', 'J01.637.051.130'], ['B01.050.150.900.649.313.500.380.271'], ['A11.251'], ['A07.015.700.500', 'A10.272.491.355'], ['E05.830.250', 'G09.188.370', 'G09.330.380.630'], ['E05.481'], ['E05.570'], ['G09.188.390.600.500', 'G09.188.670'], ['D05.750.395.616', 'D25.720.395.616', 'J01.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
[Comparative study of the effectiveness of acycloguanosine and phosphonoacetic acid in herpetic infection in cell cultures]. | A comparative study of cytotoxicity and antiherpes activity of acycloguanosine (Acg) of the Soviet and American manufacture and a Soviet preparation of phosphonoacetic acid (PAA) for herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) was carried out in primary and continuous cell cultures. The Acg preparation was sho... | ['Acyclovir', 'Animals', 'Chick Embryo', 'Drug Evaluation, Preclinical', 'Herpes Simplex', 'Organophosphorus Compounds', 'Phosphonoacetic Acid', 'Simplexvirus', 'Virus Cultivation'] | 3,014,751 | [['D03.633.100.759.758.399.454.250'], ['B01.050'], ['A13.350.150', 'A16.331.200'], ['E05.290.750', 'E05.337.550'], ['C01.925.256.466.382', 'C01.925.825.320', 'C17.800.838.790.320'], ['D02.705'], ['D02.241.081.018.677', 'D02.705.429.875'], ['B04.280.382.100.750'], ['E01.370.225.875.970', 'E05.200.875.970']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Impact of surgical case order on peri-operative outcomes for total joint arthroplasty. | INTRODUCTION: There is growing support in the literatures that peri-operative outcomes are adversely affected by surgical case order in some certain surgical procedures. This study aimed to examine if similar phenomenon is also shared in total joint arthroplasty (TJA).METHODS: A total of 6548 joints (5183 patients) tre... | ['Aged', 'Arthroplasty, Replacement', 'Cohort Studies', 'Databases, Factual', 'Female', 'Health Care Costs', 'Humans', 'Length of Stay', 'Male', 'Middle Aged', 'Operative Time', 'Postoperative Complications', 'Preoperative Period', 'Retrospective Studies', 'Risk Factors', 'Time Factors'] | 29,445,962 | [['M01.060.116.100'], ['E04.555.110.110', 'E04.650.110', 'E04.680.101.110'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['N03.219.151.400', 'N05.300.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.760.400.480', 'N02.42... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Information Science [L]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Educating Our Future Colleagues: Creating an MSW Palliative Care Practicum. | As the number of older adults and those with chronic medical conditions continues to rise, the need to train social work students in palliative and end-of-life competencies becomes critical. To address this growing need, the social work team at a large urban academic medical center in the Midwest developed an MSW conce... | ['Clinical Clerkship', 'Curriculum', 'Education, Graduate', 'Hospice Care', 'Humans', 'Palliative Care', 'Politics', 'Professional Competence', 'Social Work', 'Teaching', 'Terminal Care'] | 30,895,894 | [['I02.358.105'], ['I02.158'], ['I02.358.337'], ['E02.760.905.400', 'N02.421.585.905.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.760.666', 'N02.421.585.666'], ['I01.738'], ['I02.399.630'], ['I01.880.792', 'N02.421.849'], ['I02.903'], ['E02.760.905', 'N02.421.585.905']] | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Therapeutical management of depression during adolescence. | Our model of reference remains essentially the psychoanalytic theory of psychic functioning which has permitted us to have a general outlook on the individual: taking into account the genetic and biological aspects of mental functioning, cognitive capacities, requirements concerning learning, as well as the role of aff... | ['Adolescent', 'Antidepressive Agents', 'Depressive Disorder', 'Humans', 'Narcissism', 'Parent-Child Relations', 'Psychology, Adolescent', 'Psychotherapy', 'Role'] | 8,672,730 | [['M01.060.057'], ['D27.505.954.427.700.122'], ['F03.600.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.739.794.582'], ['F01.829.263.370.290'], ['F04.096.628.065'], ['F04.754'], ['F01.829.316.616']] | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Bayesian mapping of genomewide interacting quantitative trait loci for ordinal traits. | Development of statistical methods and software for mapping interacting QTL has been the focus of much recent research. We previously developed a Bayesian model selection framework, based on the composite model space approach, for mapping multiple epistatic QTL affecting continuous traits. In this study we extend the c... | ['Animals', 'Bayes Theorem', 'Chromosome Mapping', 'Epistasis, Genetic', 'Fetal Death', 'Genome', 'Mice', 'Models, Genetic', 'Quantitative Trait Loci'] | 17,507,680 | [['B01.050'], ['E05.318.740.600.200', 'N05.715.360.750.625.150', 'N06.850.520.830.600.200'], ['E05.393.183'], ['G05.308.207'], ['C13.703.223', 'C23.550.260.585'], ['G05.360.340'], ['B01.050.150.900.649.313.992.635.505.500'], ['E05.599.395.397'], ['G05.360.340.024.380.937']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Early-Onset Preeclampsia Is Associated With Gut Microbial Alterations in Antepartum and Postpartum Women. | Background: Imbalances in gut microbiota composition are linked to hypertension, host metabolic abnormalities, systemic inflammation, and other conditions. In the present study, we examined the changes of gut microbiota in women with early-onset preeclampsia (PE) and in normotensive, uncomplicated pregnant women during... | ['Adult', 'Bacteria', 'Birth Weight', 'Cohort Studies', 'Dysbiosis', 'Fatty Acid-Binding Proteins', 'Female', 'Gastrointestinal Microbiome', 'Haptoglobins', 'Humans', 'Interleukin-6', 'Lipopolysaccharides', 'Postpartum Period', 'Pre-Eclampsia', 'Pregnancy', 'Protein Precursors', 'RNA, Ribosomal, 16S'] | 31,297,341 | [['M01.060.116'], ['B03'], ['C23.888.144.186', 'E01.370.600.115.100.160.120.186', 'E05.041.124.160.750.149', 'G07.100.100.160.120.186', 'G07.345.249.314.120.186'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['C23.550.308'], ['D12.776.157.170'], ['G06.591.375', 'G16.500.275.157.049.10... | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Intravenous digital subtraction renal angiography: use in screening for renovascular hypertension. | Intravenous digital subtraction renal angiography (DSRA) has been compared with conventional angiography only in small, selected series of hypertensive patients. The authors prospectively examined with intravenous DSRA 94 patients at increased risk for renovascular hypertension and compared these studies with conventio... | ['Adult', 'Aged', 'Angiography', 'Female', 'Humans', 'Hypertension, Renovascular', 'Male', 'Middle Aged', 'Prospective Studies', 'Radiographic Image Enhancement', 'Renal Artery Obstruction', 'Subtraction Technique'] | 2,648,471 | [['M01.060.116'], ['M01.060.116.100'], ['E01.370.350.700.060', 'E01.370.370.050'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.777.419.331.490', 'C13.351.968.419.331.490', 'C14.907.489.631.485'], ['M01.060.116.630'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], [... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]', 'Information Science [L]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Innervation and myoepithelial arrangements in the submandibular salivary gland of ferret investigated by enzyme, catecholamine and filament histochemistry. | Although the submandibular gland of ferret is useful for studying salivary secretory processes which are regulated by nerves and involve myoepithelial activity, little attention has been paid to its parenchymal innervation and myoepithelial arrangements. Therefore, glands obtained postmortem from mature ferrets of both... | ['Actin Cytoskeleton', 'Animals', 'Catecholamines', 'Cholinesterases', 'Enzymes', 'Epithelial Cells', 'Female', 'Ferrets', 'Fluorescence', 'Histocytochemistry', 'Male', 'Phosphoric Monoester Hydrolases', 'Phosphorylases', 'Staining and Labeling', 'Submandibular Gland'] | 10,669,082 | [['A11.284.430.214.190.750.050'], ['B01.050'], ['D02.092.311', 'D02.455.426.559.389.657.166.175'], ['D08.811.277.352.100.170'], ['D08.811'], ['A11.436'], ['B01.050.150.900.649.313.750.250.575.350'], ['G01.358.500.505.650.665.500', 'G01.590.540.665.500'], ['E01.370.225.500.607', 'E01.370.225.750.551', 'E05.200.500.607',... | ['Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Prognostic Factors and Treatment Outcomes of Parotid Gland Cancer: A 10-Year Single-Center Experience. | OBJECTIVE: To investigate the treatment outcomes of parotid gland cancer at a single center over a 10-year period and to evaluate the prognostic significance of maximum standardized uptake value.STUDY DESIGN: Retrospective case series with chart review.SETTING: Academic care center.SUBJECTS AND METHODS: Ninety-eight pa... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Carcinoma, Acinar Cell', 'Carcinoma, Mucoepidermoid', 'Child', 'Female', 'Fluorodeoxyglucose F18', 'Humans', 'Lymphatic Metastasis', 'Male', 'Middle Aged', 'Neoplasm Recurrence, Local', 'Parotid Neoplasms', 'Prognosis', 'Retrospective Studies', 'Tomography, Emission... | 26,203,086 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C04.557.470.200.025.215'], ['C04.557.470.200.025.340', 'C04.557.470.590.340'], ['M01.060.406'], ['D09.254.229.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.697.650.560', 'C23.550.727.650.560'], ['M01.060.116.630'], ['C04.... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
G protein-dependent CCR5 signaling is not required for efficient infection of primary T lymphocytes and macrophages by R5 human immunodeficiency virus type 1 isolates. | The requirement of human immunodeficiency virus (HIV)-induced CCR5 activation for infection by R5 HIV type 1 (HIV-1) strains remains controversial. Ectopic CCR5 expression in CD4(+)-transformed cells or pharmacological inhibition of G(alpha)i proteins coupled to CCR5 left unsolved whether CCR5-dependent cell activation... | ['CD4-Positive T-Lymphocytes', 'Cell Line', 'Cells, Cultured', 'GTP-Binding Proteins', 'HIV Infections', 'HIV-1', 'Humans', 'Lentivirus', 'Macrophages', 'Receptors, CCR5', 'Signal Transduction', 'Virus Replication'] | 12,551,993 | [['A11.118.637.555.567.569.200', 'A15.145.229.637.555.567.569.200', 'A15.382.490.555.567.569.200'], ['A11.251.210'], ['A11.251'], ['D08.811.277.040.330.300', 'D12.776.157.325'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['B04.820.650.589.... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effect of t-butyl hydroperoxide on Ca2+ movement in PC12 pheochromocytoma cells. | The effect of the oxidant t-butyl hydroperoxide on intracellular free levels of Ca2+ ([Ca2+]i) in PC12 pheochromocytoma cells was examined by using fura-2 as a fluorescent dye. t-Butyl hydroperoxide induced an increase in [Ca2+]i in a concentration-dependent fashion between 50-250 microM with an EC50 of 100 microM. The... | ['Adenosine Triphosphate', 'Animals', 'Calcium', 'Calcium Channel Blockers', 'Enzyme Inhibitors', 'Estrenes', 'Fluorescent Dyes', 'Fura-2', 'Neurons', 'PC12 Cells', 'Phosphodiesterase Inhibitors', 'Pyrrolidinones', 'Rats', 'Thapsigargin', 'Type C Phospholipases', 'tert-Butylhydroperoxide'] | 12,817,717 | [['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D27.505.519.562.249', 'D27.505.696.260.500', 'D27.505.954.411.192'], ['D27.505.519.389'], ['D04.210.500.365.415'], ['D27.720.233.348', 'D27.720.470.410.505.500'], ['D03.3... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Sodium intake in infancy and blood pressure at 7 years: findings from the Avon Longitudinal Study of Parents and Children. | BACKGROUND: Infancy may be a sensitive period regarding effects of sodium intake on future blood pressure (BP). This has only been demonstrated in one randomized trial of low sodium formulae with follow-up in adolescence in one-third of participants.OBJECTIVE: To prospectively assess associations between sodium intake ... | ['Aging', 'Blood Pressure', 'Child', 'Cohort Studies', 'Diastole', 'England', 'Female', 'Humans', 'Infant', 'Infant Nutritional Physiological Phenomena', 'Male', 'Nutrition Policy', 'Potassium, Dietary', 'Prospective Studies', 'Sodium, Dietary', 'Systole', 'Time Factors'] | 17,622,260 | [['G07.345.124'], ['E01.370.600.875.249', 'G09.330.380.076'], ['M01.060.406'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['G09.330.580.295', 'G11.427.494.554.250', 'G11.427.494.570.295'], ['Z01.542.363.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['G07.20... | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Health Care [N]', 'Geographicals [Z]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Rapid microwave-assisted chemical cleavage - mass spectrometric method for the identification of hemoglobin variants in blood. | A sensitive, rapid analytical method has been developed for the characterization of human hemoglobin disorders with very small volumes (<1 ìL) of blood. As an alternative to conventional enzymatic digestion, a site-specific chemical cleavage method has been established using 0.05% formic acid under microwave-irradiatio... | ['Amino Acid Sequence', 'Chromatography, Liquid', 'Hemoglobins', 'Humans', 'Microwaves', 'Models, Molecular', 'Molecular Sequence Data', 'Spectrometry, Mass, Electrospray Ionization', 'Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization', 'Tandem Mass Spectrometry'] | 20,936,783 | [['G02.111.570.060', 'L01.453.245.667.060'], ['E05.196.181.400'], ['D12.776.124.400', 'D12.776.422.316.762'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.358.500.505.810.500', 'G01.750.250.810.500', 'G01.750.770.721.500'], ['E05.599.595'], ['L01.453.245.667'], ['E05.196.566.600'], ['E05.196.566.755'], ['E05.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Acute isolated lateral compartment syndrome of the leg after a noncontact sports injury. | Compartment syndrome of the leg typically affects the anterior compartment or multiple compartments and can be traumatic or exertional (chronic) in nature. Isolated lateral (peroneal) compartment syndrome of the leg is a less typical and lesser-known condition that can potentially escape diagnosis if not considered in ... | ['Acute Disease', 'Adult', 'Compartment Syndromes', 'Decompression, Surgical', 'Humans', 'Male', 'Soccer', 'Treatment Outcome'] | 19,634,843 | [['C23.550.291.125'], ['M01.060.116'], ['C05.651.180', 'C14.907.303'], ['E04.188'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I03.450.642.845.800'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800']] | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Deaths due to choking in Prader-Willi syndrome. | Prader-Willi syndrome (PWS) is the most common known syndromic cause of life-threatening obesity, yet few studies have examined the causes of death in PWS. The objective of this study was to examine the contribution of choking leading to mortality in PWS. In 1999, a brief survey was made available from the Prader-Willi... | ['Adolescent', 'Adult', 'Airway Obstruction', 'Child', 'Child, Preschool', 'Female', 'Humans', 'Male', 'Middle Aged', 'Prader-Willi Syndrome', 'Vomiting'] | 17,036,318 | [['M01.060.057'], ['M01.060.116'], ['C08.618.846.185'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C10.597.606.360.690', 'C16.131.077.730', 'C16.131.260.700', 'C16.320.180.700', 'C18.654.726.500.740'], ['C23.888.821.937']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[A multicenter, double-blind, randomized, placebo-controlled clinical trial of etanercept treatment of Chinese patients with active ankylosing spondylitis]. | OBJECTIVE: To evaluate the efficacy and safety of etanercept 50 mg once-weekly treatment of Chinese patients with active ankylosing spondylitis (AS).METHODS: Four hundred patients with active AS, enrolled in six medical centers, were randomly divided into either the treatment group or the placebo group in a 3:1 ratio. ... | ['Adolescent', 'Adult', 'Aged', 'Double-Blind Method', 'Etanercept', 'Female', 'Humans', 'Immunoglobulin G', 'Male', 'Middle Aged', 'Receptors, Tumor Necrosis Factor', 'Spondylitis, Ankylosing', 'Treatment Outcome', 'Young Adult'] | 22,333,175 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['D12.644.541.500.697.624', 'D12.776.124.486.485.538.500.624', 'D12.776.124.486.485.680.697.624', 'D12.776.124.790.651.538.500.624', 'D12.776.124.790.651.680.660.624', 'D12.776.3... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation. | The composite structure of the mammalian skull, which forms predominantly via intramembranous ossification, requires precise pre- and post-natal growth regulation of individual calvarial elements. Disturbances of this process frequently cause severe clinical manifestations in humans. Enhanced DNA binding by a mutant MS... | ['Abnormalities, Multiple', 'Animals', 'Bone Development', 'Bone and Bones', 'Cartilage', 'Cell Differentiation', 'Cell Division', 'Cerebellum', 'Chondrocytes', 'DNA-Binding Proteins', 'Ectodermal Dysplasia', 'Hair Follicle', 'Homeodomain Proteins', 'Mammary Glands, Animal', 'Mice', 'Mice, Knockout', 'Mice, Mutant Stra... | 10,742,104 | [['C16.131.077'], ['B01.050'], ['G07.345.500.325.377.625.050.500', 'G11.427.578.050.500'], ['A02.835.232', 'A10.165.265'], ['A02.165', 'A10.165.382'], ['G04.152'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A08.186.211.132.810.428.200'], ['A11.329.171'], ['D12.776.260'], ['C16.131.077.3... | ['Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Experiences with aluminum matrices of anterior teeth with a clamping device--a contribution to the planning of front tooth fillings]. | Starting from the description of an innovator's suggestion (registration number: 172097), the author deals with the use of suitable anterior matrixes made of aluminium foil. Practical experience and clinical results with the filling material Frontasil recommend the technique described for wide use. | ['Aluminum', 'Humans', 'Incisor', 'Mouth Rehabilitation', 'Technology, Dental'] | 268,071 | [['D01.268.557.050', 'D01.552.547.050'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A14.549.167.860.425'], ['E06.584'], ['E06.912', 'H02.010.800', 'J01.897.724']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Urinary tract injury associated with pelvic fractures. | INTRODUCTION: Pelvic trauma associated with urinary tract injury is a severe trauma, mostly caused by traffic accidents and falls from heights. These injuries require urgent treatment and close teamwork between urologic and orthopaedic surgeons.MATERIAL AND METHODS: In this retrospective study there were analyzed patie... | ['Accidents, Traffic', 'Female', 'Fracture Fixation', 'Fractures, Bone', 'Humans', 'Male', 'Middle Aged', 'Outcome Assessment, Health Care', 'Patient Care Team', 'Pelvic Bones', 'Retrospective Studies', 'Trauma Severity Indices', 'Urinary Tract', 'Urologic Surgical Procedures'] | 25,782,218 | [['N06.850.135.392'], ['E04.555.300'], ['C26.404'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['H01.770.644.145.431', 'N04.761.559.590', 'N05.715.360.575.575'], ['N04.590.715'], ['A02.835.232.043.825'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N0... | ['Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Disciplines and Occupations [H]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Internet-based and other computerized psychological treatments for adult depression: a meta-analysis. | Computerized and, more recently, Internet-based treatments for depression have been developed and tested in controlled trials. The aim of this meta-analysis was to summarize the effects of these treatments and investigate characteristics of studies that may be related to the effects. In particular, the authors were int... | ['Adult', 'Depressive Disorder', 'Humans', 'Internet', 'Therapy, Computer-Assisted'] | 20,183,695 | [['M01.060.116'], ['F03.600.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.230.110.500'], ['E02.950', 'L01.313.500.750.100.710']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
An unusually large cavernous hemangioma of retropharyngeal space: a rare case. | Hemangiomas rarely occur in the retropharyngeal space with only several cases reported in the current literature. This article reports the hemangiomas of retropharyngeal space. A 55-year-old woman was referred to our institution for dysphagia. Computed tomography and magnetic resonance imaging of the neck and spine rev... | ['Diagnosis, Differential', 'Female', 'Hemangioma, Cavernous', 'Humans', 'Magnetic Resonance Imaging', 'Middle Aged', 'Pharyngeal Neoplasms', 'Tomography, X-Ray Computed'] | 26,011,223 | [['E01.171'], ['C04.557.645.375.385', 'C14.907.454.385', 'C15.378.463.515.385'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['M01.060.116.630'], ['C04.588.443.665.710', 'C07.550.745', 'C09.647.710', 'C09.775.549'], ['E01.370.350.350.810', 'E01.370.350.600.350.700.810', 'E01.370.350.700.70... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Single stranded siRNA complexation through non-electrostatic interactions. | As double stranded, single stranded siRNA (ss-siRNA) has demonstrated gene silencing activity but still requires efficient carriers to reach its cytoplasmic target. To better understand the fundamental aspect driving the complexation of ss-siRNA with nanocarriers, the interactions between surfaces of various compositio... | ['Adsorption', 'Binding Sites', 'Cations', 'Hydrophobic and Hydrophilic Interactions', 'Liposomes', 'Micelles', 'Nucleic Acid Conformation', 'RNA, Small Interfering', 'Static Electricity'] | 27,825,070 | [['G01.030', 'G02.020'], ['G02.111.570.120'], ['D01.248.497.300'], ['G02.409'], ['D25.479.517', 'D26.255.260.517', 'J01.637.051.479.517', 'J01.637.087.500.517'], ['D05.374', 'D26.255.560'], ['G02.111.570.820.486', 'G05.360.580'], ['D13.150.650.700', 'D13.444.735.150.700', 'D13.444.735.790.552.875'], ['G01.358.500.249.8... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
A Characterization of Student Reflections in an Introductory Pharmacy Practice Experience Discussion Course. | Objective. To characterize weekly student reflections in an introductory pharmacy practice experience (IPPE) discussion course meeting concurrently with IPPE rotations in institutional pharmacy. Methods. A qualitative analysis was conducted to identify themes within weekly reflective statements submitted by second year... | ['Curriculum', 'Education, Pharmacy', 'Humans', 'Patient Care Team', 'Pharmaceutical Services', 'Pharmacists', 'Pharmacy Technicians', 'Professional Role', 'Students, Pharmacy'] | 29,692,440 | [['I02.158'], ['I02.358.525'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N04.590.715'], ['N02.421.668'], ['M01.526.485.780', 'N02.360.780'], ['M01.526.485.067.735', 'N02.360.067.730'], ['F01.829.316.616.625'], ['M01.848.769.768']] | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Health Care [N]', 'Named Groups [M]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
[Cathepsin D and the catabolic degradation of proteoglycans in granulomatous tissue]. | Incubated in vitro at 37 degrees C, granulation tissues release glycosaminoglycans into the incubation medium. Such release is inhibited if pepstatine is present in the medium. From this result, it can be inferred that the protien moiety of the proteioglycans is degraded by cathepsin D. Therefore a role of this enzy... | ['Animals', 'Cathepsins', 'Glycosaminoglycans', 'Granuloma', 'Pepstatins', 'Proteoglycans', 'Rats', 'Temperature'] | 125,156 | [['B01.050'], ['D08.811.277.656.224'], ['D09.698.373'], ['C15.604.515.292', 'C23.550.382'], ['D12.644.456.724'], ['D09.698.735', 'D12.776.395.650'], ['B01.050.150.900.649.313.992.635.505.700'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.150.450', 'N06.230.300.100.725.710']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Activation of eosinophils with cytokines produced by lung mast cells. | Here we show that the supernatant from activated lung mast cells induced the release of eosinophil cationic protein (ECP) from eosinophils. Lung mast cells were purified using affinity magnetic selection with monoclonal antibody (mAb) YB5.B8 to achieve a final mast cell purity of 93-99%. Eosinophils were purified by im... | ['Blood Proteins', 'Cell Communication', 'Cells, Cultured', 'Cytokines', 'Eosinophil Granule Proteins', 'Eosinophils', 'Granulocyte-Macrophage Colony-Stimulating Factor', 'Humans', 'Interleukin-5', 'Mast Cells', 'Ribonucleases', 'Tumor Necrosis Factor-alpha'] | 9,363,932 | [['D12.776.124'], ['G04.085'], ['A11.251'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['D12.776.124.486.379'], ['A11.118.637.415.345', 'A11.627.340.345', 'A15.145.229.637.415.345', 'A15.382.490.315.251'], ['D12.644.276.374.410.240.375', 'D12.776.395.240.300', 'D12.776.467.374.410.240.375', 'D23.529.374.410... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Poverty, race, and CKD in a racially and socioeconomically diverse urban population. | BACKGROUND: Low socioeconomic status (SES) and African American race are both independently associated with end-stage renal disease and progressive chronic kidney disease (CKD). However, despite their frequent co-occurrence, the effect of low SES independent of race has not been well studied in CKD.STUDY DESIGN: Cross-... | ['Adult', 'African Americans', 'Chronic Disease', 'Cross-Sectional Studies', 'European Continental Ancestry Group', 'Female', 'Glomerular Filtration Rate', 'Humans', 'Kidney Diseases', 'Logistic Models', 'Male', 'Middle Aged', 'Poverty', 'Prevalence', 'Socioeconomic Factors', 'United States', 'Urban Population'] | 20,207,457 | [['M01.060.116'], ['M01.686.508.100.100', 'M01.686.754.100'], ['C23.550.291.500'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['M01.686.508.400'], ['E01.370.390.400.300', 'G08.852.357'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.777.419', 'C13.351.968.419'], ['E05.318.74... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
When should students learn essential physical examination skills? Views of internal medicine clerkship directors in North America. | PURPOSE: To determine whether any consensus exists among internal medicine clerkship directors regarding when students should acquire proficiency in selected physical examination (PE) skills.METHOD: In 2004, the annual survey of Clerkship Directors in Internal Medicine (CDIM) included a question about the timing of PE-... | ['Adult', 'Clinical Clerkship', 'Curriculum', 'Education, Medical, Undergraduate', 'Humans', 'Internal Medicine', 'North America', 'Physical Examination', 'Students, Medical', 'Surveys and Questionnaires'] | 18,162,759 | [['M01.060.116'], ['I02.358.105'], ['I02.158'], ['I02.358.399.450'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H02.403.429'], ['Z01.107.567'], ['E01.370.600'], ['M01.848.769.602'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980']] | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Sexual Portrait of Couples Seeking Relationship Therapy. | This study sought to provide information about the sexual well-being of 298 mixed-sex couples seeking relationship therapy and determined the extent to which problems with sexual functioning and dyadic adjustment of both partners are associated with sexual satisfaction. Partners completed measures of dyadic adjustment,... | ['Adult', 'Aged', 'Couples Therapy', 'Female', 'Humans', 'Interpersonal Relations', 'Male', 'Middle Aged', 'Personal Satisfaction', 'Quebec', 'Sexual Behavior', 'Sexual Dysfunctions, Psychological', 'Spouses', 'Young Adult'] | 29,577,354 | [['M01.060.116'], ['M01.060.116.100'], ['F04.754.864.581.136'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.401'], ['M01.060.116.630'], ['F01.145.677'], ['Z01.107.567.176.791'], ['F01.145.802'], ['F03.835'], ['F01.829.263.500.660', 'I01.880.853.150.500.670', 'M01.816'], ['M01.060.116.815']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 |
The energy production of the adult Schistosoma mansoni is for a large part aerobic. | Pairs of adult Schistosoma mansoni were collected by perfusion of the mesenteric veins of experimentally infected hamsters which were anaesthetized with ether. The parasites were incubated in a simple salt medium with D-[6-14C]glucose for 3 h at 37 degrees C. Under aerobic conditions a considerable amount of labelled C... | ['Adenosine Triphosphate', 'Aerobiosis', 'Anaerobiosis', 'Animals', 'Carbon Dioxide', 'Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone', 'Citric Acid Cycle', 'Cricetinae', 'Culture Media', 'Energy Metabolism', 'Glucose', 'Oligomycins', 'Oxidative Phosphorylation', 'Schistosoma mansoni'] | 3,929,086 | [['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['G02.111.017', 'G03.049'], ['G02.111.062', 'G03.078'], ['B01.050'], ['D01.200.200', 'D01.362.150', 'D01.650.550.200'], ['D02.442.288.220', 'D02.626.270'], ['G02.111.165', 'G03.295.342', 'G03.493.170'], ['B01.050.150.900.649.313.992.635.075... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Apparent encoding of sequential context in rat medial prefrontal cortex is accounted for by behavioral variability. | Simple sequences can be represented via asymmetrically linked neural assemblies, provided that the elements of the sequence are unique. When elements repeat, however (e.g., A-B-C-B-A), the same element belongs to two separate "sequential contexts," and a more complex encoding mechanism is required. To enable correct se... | ['Action Potentials', 'Animals', 'Male', 'Maze Learning', 'Prefrontal Cortex', 'Psychomotor Performance', 'Rats', 'Rats, Inbred BN', 'Rats, Inbred F344', 'Reaction Time', 'Reward'] | 17,182,765 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['B01.050'], ['F02.463.425.874.500'], ['A08.186.211.200.885.287.500.270.700'], ['F02.808', 'G11.427.700', 'G11.561.660'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760.110', 'B01.050.150.900.649.313.992.635.505.700.400.110'], ['B01.050.050... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Fluorophore-tagged pharmacophores for antitumor cytotoxicity: Modified chiral lipidic dialkynylcarbinols for cell imaging. | Chiral lipidic dialkynylcarbinols (DACs), recently highlighted as antitumoral pharmacophores, have been conjugated to difluoroboron-dipyrromethene (bodipy), 7-hydroxy-coumarine, and 7-nitro-benzoxadiazole (NBD) fluorophore motifs through triazole clips. The labeled lipids preserve cytotoxic activity against HCT116 cell... | ['Antineoplastic Agents', 'Boron Compounds', 'Cell Proliferation', 'Dose-Response Relationship, Drug', 'Drug Screening Assays, Antitumor', 'Fluorescent Dyes', 'HCT116 Cells', 'HeLa Cells', 'Humans', 'Lipids', 'Methanol', 'Microscopy, Fluorescence', 'Molecular Imaging', 'Molecular Structure', 'Structure-Activity Relatio... | 26,342,865 | [['D27.505.954.248'], ['D01.132', 'D02.203'], ['G04.161.750', 'G07.345.249.410.750'], ['G07.690.773.875', 'G07.690.936.500'], ['E01.370.225.500.388', 'E05.200.500.388', 'E05.242.417', 'E05.337.550.200'], ['D27.720.233.348', 'D27.720.470.410.505.500'], ['A11.251.210.190.380', 'A11.251.860.180.380'], ['A11.251.210.190.40... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Thyrotoxicosis: an unusual cause of syncope. | Syncope is a common emergency department (ED) chief complaint, with many known but also unknown causes. Here we present a novel ED presentation of a young woman with new-onset hyperthyroidism that masqueraded as a syncopal event with head trauma. A 21-year-old woman arrived in the ED with head trauma as the result of s... | ['Antithyroid Agents', 'Craniocerebral Trauma', 'Diagnosis, Differential', 'Electrocardiography', 'Female', 'Humans', 'Methimazole', 'Syncope', 'Tachycardia', 'Thyroid Function Tests', 'Thyrotoxicosis', 'Young Adult'] | 30,700,385 | [['D06.347.100', 'D27.505.696.399.450.100'], ['C10.900.300', 'C26.915.300'], ['E01.171'], ['E01.370.370.380.240', 'E01.370.405.240'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.886.489.600', 'D03.383.129.308.535'], ['C10.597.606.358.800.600', 'C23.888.592.604.359.800.600'], ['C14.280.067.845', 'C14.280.123.... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Cbl-b deficiency provides protection against UVB-induced skin damage by modulating inflammatory gene signature. | Exposure of skin to ultraviolet (UV) radiation induces DNA damage, inflammation, and immune suppression that ultimately lead to skin cancer. However, some of the pathways that regulate these events are poorly understood. We exposed mice to UVB to study its early effects in the absence of Cbl-b, a known suppressor of an... | ['Adaptor Proteins, Signal Transducing', 'Animals', 'Gene Expression Regulation', 'Inflammation', 'Matrix Metalloproteinase 12', 'Mice', 'Mice, Inbred C57BL', 'Mice, Knockout', 'Proto-Oncogene Proteins c-cbl', 'Skin', 'T-Lymphocytes, Regulatory', 'Ultraviolet Rays', 'beta Catenin'] | 30,082,827 | [['D12.644.360.024', 'D12.776.157.057', 'D12.776.476.024'], ['B01.050'], ['G05.308'], ['C23.550.470'], ['D08.811.277.656.300.480.525.700.500', 'D08.811.277.656.675.374.525.700.500', 'D12.644.276.848.500', 'D12.776.467.836.500'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.9... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Persistence of contact allergy: a retrospective analysis. | BACKGROUND: Studies have shown that not all positive patch test reactions are reproducible upon retesting, that is, persistent. Non-persistent reactions might represent initial false-positive reactions, meaning that patients might unnecessarily avoid allergens.OBJECTIVES: To investigate the occurrence of both persisten... | ['Adult', 'Allergens', 'Dermatitis, Allergic Contact', 'False Positive Reactions', 'Female', 'Humans', 'Male', 'Middle Aged', 'Patch Tests', 'Reproducibility of Results', 'Retrospective Studies'] | 29,178,341 | [['M01.060.116'], ['D23.050.063'], ['C17.800.174.255.100', 'C17.800.815.255.100', 'C20.543.418.150'], ['E01.354.506'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.370.225.812.871.610', 'E05.200.812.871.610', 'E05.478.594.890.610'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685'... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The influence of cell mechanics, cell-cell interactions, and proliferation on epithelial packing. | BACKGROUND: Epithelial junctional networks assume packing geometries characterized by different cell shapes, neighbor number distributions and areas. The development of specific packing geometries is tightly controlled; in the Drosophila wing epithelium, cells convert from an irregular to a hexagonal array shortly befo... | ['Animals', 'Biomechanical Phenomena', 'Cell Adhesion', 'Cell Communication', 'Cell Division', 'Cell Proliferation', 'Drosophila', 'Epithelial Cells', 'Lasers', 'Models, Biological'] | 18,082,406 | [['B01.050'], ['G01.154.090', 'G01.374.089'], ['G04.022'], ['G04.085'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['G04.161.750', 'G07.345.249.410.750'], ['B01.050.500.131.617.720.500.500.750.310.250'], ['A11.436'], ['E07.632.490', 'E07.710.520'], ['E05.599.395']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Characterization of the chromatin acceptor sites for the avian oviduct progesterone receptor using monoclonal antibodies. | Monoclonal antibodies (MAb) against the chromatin acceptor sites for the avian oviduct progesterone receptor were prepared with highly purified hen oviduct acceptor proteins reconstituted to hen DNA. Addition of the MAbs to a cell-free assay blocked progesterone receptor from chick oviduct (PRov) binding to native-like... | ['Animals', 'Antibodies, Monoclonal', 'Antigen-Antibody Complex', 'Chickens', 'Chromatin', 'DNA', 'Enzyme-Linked Immunosorbent Assay', 'Female', 'Kinetics', 'Nucleoproteins', 'Oviducts', 'Receptors, Progesterone'] | 3,676,291 | [['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D12.776.124.486.485.114.257', 'D12.776.124.790.651.114.257', 'D12.776.377.715.548.114.257', 'D23.050.101'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['A11.284.430.106.279.345.190.160.180... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Necrotising enterocolitis in a term neonate with trisomy 21 exposed to maternal HIV and antiretroviral medication. | Necrotising enterocolitis (NEC) was diagnosed in a term infant with Down's syndrome exposed to maternal human immunodeficiency virus (HIV) infection and antiretroviral therapy. | ['Amoxicillin-Potassium Clavulanate Combination', 'Anti-Bacterial Agents', 'Anti-Retroviral Agents', 'Combined Modality Therapy', 'Down Syndrome', 'Enterocolitis, Necrotizing', 'Female', 'Gentamicins', 'HIV Infections', 'Humans', 'Infant, Newborn', 'Mothers'] | 18,509,676 | [['D02.065.589.099.374.160.060', 'D02.065.589.099.750.750.050.050.060', 'D02.886.108.750.750.050.050.060', 'D03.633.100.300.374.160.060', 'D03.633.100.300.750.750.050.050.500', 'D26.310.102'], ['D27.505.954.122.085'], ['D27.505.954.122.388.077'], ['E02.186'], ['C10.597.606.360.220', 'C16.131.077.327', 'C16.131.260.260'... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Structure and expression of the mouse necdin gene. Identification of a postmitotic neuron-restrictive core promoter. | Necdin is a 325 amino acid residue protein encoded by a cDNA clone isolated from neurally differentiated embryonal carcinoma cells. In situ hybridization histochemistry revealed that necdin mRNA-containing cells in vivo coincided with postmitotic neurons in the mouse brain from early periods of neurogenesis until adult... | ['Amino Acid Sequence', 'Animals', 'Base Sequence', 'Cell Differentiation', 'Fetus', 'Gene Deletion', 'Gene Expression Regulation, Developmental', 'Mice', 'Molecular Sequence Data', 'Nerve Tissue Proteins', 'Neurons', 'Nuclear Proteins', 'Promoter Regions, Genetic', 'Tumor Cells, Cultured'] | 8,557,705 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G04.152'], ['A16.378'], ['G05.365.590.762.320', 'G05.558.800.320'], ['G05.308.310'], ['B01.050.150.900.649.313.992.635.505.500'], ['L01.453.245.667'], ['D12.776.631'], ['A08.675', 'A11.671'], ['D12.776... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Carcinogenicity of 1,3-butadiene in C57BL/6 x C3H F1 mice at low exposure concentrations. | The carcinogenicity of inhaled 1,3-butadiene was evaluated in C57BL/6 x C3H F1 mice exposed to concentrations of this gas ranging from 6.25 to 625 ppm. Butadiene is a high production volume chemical, used mainly in the manufacture of synthetic rubber. In these 2-yr inhalation studies, a potent multisite carcinogenic re... | ['Animals', 'Butadienes', 'Dose-Response Relationship, Drug', 'Female', 'Heart Neoplasms', 'Hemangiosarcoma', 'Leukemia, Lymphocytic, Chronic, B-Cell', 'Lung Neoplasms', 'Male', 'Mice', 'Mice, Inbred C3H', 'Mice, Inbred C57BL', 'Neoplasms, Experimental', 'Stomach Neoplasms'] | 2,208,121 | [['B01.050'], ['D02.455.326.271.665.146.240'], ['G07.690.773.875', 'G07.690.936.500'], ['C04.588.894.309', 'C14.280.459'], ['C04.557.450.795.390', 'C04.557.645.390'], ['C04.557.337.428.080.125', 'C15.604.515.560.080.125', 'C20.683.515.528.080.125'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['B01.050.150.9... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Prescription audit adjunct to rational pharmacotherapy education improves prescribing skills of medical students. | OBJECTIVE: To assess the impact of a rational pharmacotherapy (RP) teaching program during clinical pharmacology clerkship by analyzing the results of prescription audits (PAs) of the medical students. Collectively, we intended to observe the possible improvement of the students in their prescribing, problem solving an... | ['Analgesics', 'Clinical Clerkship', 'Decision Making', 'Drug Prescriptions', 'Education, Medical, Undergraduate', 'Humans', 'Osteoarthritis', 'Pharmacology, Clinical', 'Problem-Based Learning', 'Program Evaluation', 'Schools, Medical', 'Surveys and Questionnaires', 'Turkey'] | 16,187,133 | [['D27.505.696.663.850.014', 'D27.505.954.427.040'], ['I02.358.105'], ['F02.463.785.373'], ['E02.319.307', 'N02.421.668.778.500'], ['I02.358.399.450'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C05.550.114.606', 'C05.799.613'], ['H01.158.703.152', 'H02.628.512'], ['F02.463.425.720', 'I02.158.660', 'I02.903.565... | ['Chemicals and Drugs [D]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Disciplines and Occupations [H]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 |
Nebulized furosemide as a novel treatment for dyspnea in terminal cancer patients. | Three terminal cancer patients with severe dyspnea were treated with nebulized furosemide. The underlying causes of dyspnea varied. Twenty milligrams of furosemide was nebulized and inhaled four times each day. Dyspnea dramatically improved and could be controlled for weeks. No noticeable side effects were observed. In... | ['Administration, Inhalation', 'Diuretics', 'Dyspnea', 'Furosemide', 'Humans', 'Male', 'Middle Aged', 'Nebulizers and Vaporizers', 'Neoplasms', 'Terminally Ill'] | 11,779,672 | [['E02.319.267.050'], ['D27.505.696.560.500'], ['C08.618.326', 'C23.888.852.371'], ['D02.065.884.725.300', 'D02.092.146.807.300', 'D02.886.590.700.725.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E07.605'], ['C04'], ['M01.873']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Influence of enzymatic maceration on the microstructure and microhardness of compact bone. | The cleaning of fresh bones to remove their soft tissues while maintaining their structural integrity is a basic and essential part of bone studies. The primary issue is how the cleaning process influences bone microstructures and mechanical properties. We cleaned fresh lamb femurs using enzymatic maceration in compari... | ['Animals', 'Femur', 'Hardness', 'In Vitro Techniques', 'Porosity', 'Preservation, Biological', 'Sheep', 'Trypsin'] | 20,071,762 | [['B01.050'], ['A02.835.232.043.150'], ['G01.374.647'], ['E05.481'], ['G01.374.710'], ['E02.792', 'E05.760'], ['B01.050.150.900.649.313.500.380.791'], ['D08.811.277.656.300.760.895', 'D08.811.277.656.959.350.895']] | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Implications of gender for alcohol treatment research: a quantitative and qualitative review. | Previous reviews of alcohol treatment research have indicated that in the majority of studies there are no sex differences in treatment outcome. The current meta-analysis was used to measure the magnitude and direction of trends of sex difference in treatment outcome. The results indicated that women had better treatme... | ['Alcoholism', 'Female', 'Follow-Up Studies', 'Gender Identity', 'Humans', 'Male', 'Outcome Assessment, Health Care'] | 1,392,550 | [['C25.775.100.250', 'F03.900.100.350'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['F01.393.446.250', 'F01.752.747.385.200', 'F01.752.747.722.200', 'F02.739.794.793.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H01.770.644.145.431', 'N04.761.559.590', 'N05.7... | ['Diseases [C]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Developing clinical ethics support for an Australian Health Service: A survey of clinician's experiences and views. | BACKGROUND: International developments suggest that providing clinical ethics services to help clinicians negotiate ethical issues that arise in clinical practice is beneficial and reflects best practice in promoting high ethical standards and patient-centered care. The aim of this study was to explore the needs and ex... | ['Adult', 'Aged', 'Australia', 'Decision Making', 'Ethics Consultation', 'Ethics, Clinical', 'Female', 'Health Personnel', 'Health Services', 'Hospitals, Teaching', 'Humans', 'Male', 'Middle Aged', 'Patient-Centered Care', 'Surveys and Questionnaires', 'Tertiary Care Centers', 'Young Adult'] | 30,908,109 | [['M01.060.116'], ['M01.060.116.100'], ['Z01.639.100', 'Z01.678.100.373'], ['F02.463.785.373'], ['K01.752.566.479.117.200', 'N04.452.758.849.174', 'N05.350.250.200'], ['K01.752.566.479.045.500', 'K01.752.566.479.171.132', 'N05.350.200.500', 'N05.350.340.162'], ['M01.526.485', 'N02.360'], ['N02.421'], ['N02.278.020.300'... | ['Named Groups [M]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Humanities [K]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Development of uterine sarcoma after tamoxifen treatment for breast cancer: report of four cases. | Tamoxifen (TAM) is widely used in the treatment of breast cancer, and its paradoxical effects on female genital system are well known. During the past 10 years, many descriptions of nonepithelial uterine malignancies related to long-term TAM usage have been reported in the literature. Four uterine sarcoma patients who ... | ['Antineoplastic Agents, Hormonal', 'Breast Neoplasms', 'Carcinoma, Ductal, Breast', 'Carcinoma, Lobular', 'Combined Modality Therapy', 'Fatal Outcome', 'Female', 'Gynecologic Surgical Procedures', 'Humans', 'Leiomyosarcoma', 'Mastectomy', 'Middle Aged', 'Mixed Tumor, Mullerian', 'Tamoxifen', 'Treatment Outcome', 'Uter... | 16,343,223 | [['D27.505.954.248.169'], ['C04.588.180', 'C17.800.090.500'], ['C04.557.470.200.025.232.500', 'C04.557.470.615.132.500', 'C04.588.180.390', 'C17.800.090.500.390'], ['C04.557.470.200.025.305', 'C04.557.470.615.305', 'C04.588.180.437', 'C17.800.090.500.437'], ['E02.186'], ['E05.318.308.985.550.325', 'N01.224.935.698.201'... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Circulating Fibroblast Growth Factor 21 is Associated with Diastolic Dysfunction in Heart Failure Patients with Preserved Ejection Fraction. | Fibroblast growth factor 21 (FGF21), a polypeptide ligand promoted glucose homeostasis and lipids metabolism, was recently reported to attenuate cardiac hypertrophy. The aim of this study was to investigate the impact of FGF21 in diastolic heart failure. Subjects admitted for coronary angiogram were screened for heart ... | ['Aged', 'Aged, 80 and over', 'Coronary Angiography', 'Echocardiography', 'Female', 'Fibroblast Growth Factors', 'Follow-Up Studies', 'Heart Failure, Diastolic', 'Humans', 'Male', 'Middle Aged', 'Natriuretic Peptide, Brain', 'Peptide Fragments', 'Stroke Volume'] | 27,650,781 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['E01.370.350.130.625', 'E01.370.350.700.060.200', 'E01.370.370.050.200', 'E01.370.370.380.200'], ['E01.370.350.130.750', 'E01.370.350.850.220', 'E01.370.370.380.220'], ['D12.644.276.624', 'D12.776.467.624', 'D23.529.624'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Mapping of deoxydi- and trinucleotides liberated by the action of endonucleases from the silkworm and Aspergillis oryzae. | Both silkworm nuclease and nuclease O of Aspergillus oryzae mycelia hydrolyse DNA endolytically to di- and trinucleotides terminating in 5'-phosphate. These oligonucleotides were fractionated first be DEAE-cellulose chromatography with 7 M urea into the respective isoplithic groups and then analysed for the composition... | ['Animals', 'Aspergillus oryzae', 'Base Sequence', 'Bombyx', 'Chromatography, DEAE-Cellulose', 'DNA', 'Electrophoresis', 'Endonucleases', 'Oligodeoxyribonucleotides', 'Oligonucleotides', "Polynucleotide 5'-Hydroxyl-Kinase"] | 656,423 | [['B01.050'], ['B01.300.381.081.500'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['B01.050.500.131.617.720.500.500.937.650.100'], ['E05.196.181.400.383.349'], ['D13.444.308'], ['E05.196.401', 'E05.301.300'], ['D08.811.277.352.355'], ['D13.695.578.424.450'], ['D13.695.578.424'], ['D08.811.074.875', 'D08... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Impact of Out-of-Pocket Costs on Prescription Fills Among New Initiators of Biologic Therapies for Rheumatoid Arthritis. | BACKGROUND: Biologic disease-modifying antirheumatic drug (DMARD) therapies are a mainstay of treatment for rheumatoid arthritis (RA), yet high member out-of-pocket (OOP) costs for such therapies may limit patient access to these therapies.OBJECTIVE: To understand whether there is a relationship between OOP costs and t... | ['Antirheumatic Agents', 'Arthritis, Rheumatoid', 'Biological Therapy', 'Costs and Cost Analysis', 'Female', 'Health Expenditures', 'Humans', 'Male', 'Middle Aged', 'Prescription Drugs', 'Retrospective Studies'] | 27,015,251 | [['D27.505.954.329'], ['C05.550.114.154', 'C05.799.114', 'C17.300.775.099', 'C20.111.199'], ['E02.095'], ['N03.219.151'], ['N03.219.151.450', 'N05.300.385'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['D26.670'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Ultracentrifugal studies of the effect of molecular crowding by trimethylamine N-oxide on the self-association of muscle glycogen phosphorylase b. | The suitability of sedimentation equilibrium for characterizing the self-association of muscle glycogen phosphorylase b has been reappraised. Whereas sedimentation equilibrium distributions for phosphorylase b in 40 mM Hepes buffer (pH 6.8) supplemented with 1 mM AMP signify a lack of chemical equilibrium attainment, t... | ['Animals', 'Cryoprotective Agents', 'Ethylene Glycol', 'Glycerol', 'Hydrogen-Ion Concentration', 'Methylamines', 'Models, Chemical', 'Models, Statistical', 'Muscle, Skeletal', 'Phosphorylases', 'Protein Binding', 'Rabbits', 'Sucrose', 'Thermodynamics', 'Ultracentrifugation'] | 11,168,388 | [['B01.050'], ['D27.505.696.706.320', 'D27.720.799.180'], ['D02.033.455.250.268'], ['D02.033.800.875.500', 'D09.853.875.500'], ['G02.300'], ['D02.092.668'], ['E05.599.495'], ['E05.318.740.500', 'E05.599.835', 'N05.715.360.750.530', 'N06.850.520.830.500'], ['A02.633.567', 'A10.690.552.500'], ['D08.811.913.400.450.460.40... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Innovative retention strategies for nursing staff. | The creation of innovative retention strategies will be a major focus for nursing administration as a shortage of nurses recurs and turnover of staff becomes a problem. A recent study provides information on which to formulate retention strategies. The findings suggest that retention strategies, to be effective, need t... | ['Adult', 'Critical Care', 'Educational Status', 'Humans', 'Job Satisfaction', 'Models, Theoretical', 'Nursing Staff, Hospital', 'Personnel Management', 'Personnel Turnover', 'Stress, Psychological'] | 3,647,116 | [['M01.060.116'], ['E02.760.190', 'N02.421.585.190'], ['N01.824.196'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.784.692.425'], ['E05.599'], ['M01.526.485.680.490', 'M01.526.485.740.523', 'N02.360.680.490', 'N02.360.740.523'], ['N04.452.677'], ['N04.452.677.680'], ['F01.145.126.990', 'F02.830.900']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Massive hemothorax after removal of subclavian vein catheter: a very unusual complication. | A case of massive hemothorax developing a few minutes after removal of a central venous catheter is described in a 51-yr-old woman, who had undergone a renal transplant. The patient had an arteriovenous fistula for hemodialysis on the same side as the central catheter. The mechanism of the onset of this complication is... | ['Arteriovenous Shunt, Surgical', 'Catheterization, Central Venous', 'Female', 'Hemothorax', 'Humans', 'Kidney Transplantation', 'Middle Aged', 'Postoperative Complications', 'Radiography', 'Subclavian Vein'] | 11,990,937 | [['E04.035.087', 'E04.100.814.868.249'], ['E02.148.167', 'E04.100.814.529.875', 'E04.502.382.875', 'E05.157.313'], ['C08.528.380', 'C23.550.414.904'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.870.500', 'E04.936.450.485', 'E04.950.774.400'], ['M01.060.116.630'], ['C23.550.767'], ['E01.370.350.700'], ['A07.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Use of vascular sealing devices (VasoSeal and Perclose) versus assisted manual compression (Femostop) in transcatheter coronary interventions requiring abciximab (ReoPro). | UNLABELLED: Transcatheter coronary interventions requiring abciximab (ReoPro) are associated with vascular access site complications. Several devices have been developed to aid in the closure of the femoral arteriotomy, including collagen plug devices (VasoSeal, AngioSeal), percutaneous suture closure (Perclose), and a... | ['Abciximab', 'Angioplasty, Balloon, Coronary', 'Antibodies, Monoclonal', 'Anticoagulants', 'Collagen', 'Coronary Angiography', 'Female', 'Hemostasis, Surgical', 'Humans', 'Immunoglobulin Fab Fragments', 'Male', 'Middle Aged', 'Postoperative Hemorrhage', 'Treatment Outcome'] | 10,376,492 | [['D12.644.541.500.650.125', 'D12.776.124.486.485.114.224.060.125', 'D12.776.124.486.485.680.650.125', 'D12.776.124.790.651.114.224.060.125', 'D12.776.124.790.651.680.650.125', 'D12.776.377.715.548.114.224.200.125', 'D12.776.377.715.548.680.650.125'], ['E02.148.050.060.100', 'E04.100.376.719.100', 'E04.100.814.529.124.... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Cytokine-induced IL-1 beta gene expression in the human polymorphonuclear leukocyte: transcriptional and post-transcriptional regulation by tumor necrosis factor and IL-1. | We have previously demonstrated that Il-1 and TNF could rapidly, but transiently, induce gene expression of Il-1 beta in human polymorphonuclear leukocytes (PMN) at both the protein and mRNA level. Additionally, we demonstrated a cooperative effect of Il-1 and TNF on the kinetics of induction of Il-1 beta mRNA and prot... | ['Cycloheximide', 'Gene Expression Regulation', 'Half-Life', 'Humans', 'Interleukin-1', 'Neutrophils', 'RNA, Messenger', 'Transcription, Genetic', 'Tumor Necrosis Factor-alpha'] | 1,918,980 | [['D03.383.621.808.240'], ['G05.308'], ['G01.910.405'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.465.010', 'D12.644.276.374.500.400', 'D12.776.467.374.465.010', 'D12.776.467.374.500.400', 'D23.529.374.465.131', 'D23.529.374.500.400'], ['A11.118.637.415.583', 'A11.627.340.583', 'A11.733.689', '... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
HIV/AIDS education survey for mental health professionals. | A total of 6804 mental health professionals, e.g., licensed and certified psychologists, licensed professional counselors, in Arkansas, Louisiana, New Mexico, Oklahoma, and Texas were mailed a questionnaire regarding HIV/AIDS topics professionals might recommend for educational programs. Participants were asked to rate... | ['Acquired Immunodeficiency Syndrome', 'Adolescent', 'Adult', 'Aged', 'Attitude of Health Personnel', 'Child', 'Counseling', 'Curriculum', 'Female', 'HIV Infections', 'Humans', 'Male', 'Middle Aged', 'Psychology', 'United States'] | 9,676,500 | [['C01.221.250.875.040', 'C01.221.812.640.400.040', 'C01.778.640.400.040', 'C01.925.782.815.616.400.040', 'C01.925.813.400.040', 'C01.925.839.040', 'C20.673.480.040'], ['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['F01.100.050', 'N05.300.100'], ['M01.060.406'], ['F02.784.176', 'F04.408.413', 'N02.421.143.303'... | ['Diseases [C]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Perinatal exposure to dioxins and dioxin-like compounds and infant growth and body mass index at seven years: A pooled analysis of three European birth cohorts. | BACKGROUND: Dioxins and dioxin-like compounds are endocrine disrupting chemicals (EDCs). Experimental studies suggest perinatal exposure to EDCs results in later obesity. However, the few epidemiological investigations on dioxins are inconclusive. We investigated perinatal exposure to dioxins and dioxin-like compounds,... | ['Body Mass Index', 'Child Development', 'Cohort Studies', 'Dioxins', 'Europe', 'Female', 'Humans', 'Infant', 'Maternal Exposure', 'Pregnancy'] | 27,311,652 | [['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['F01.525.200', 'G07.345.374.750'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['D02.309.500', 'D03.383.231'], ['Z01.542'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'],... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Efficacy of polyglycolic acid sheets and fibrin glue for prevention of bleeding after gastric endoscopic submucosal dissection in patients under continued antithrombotic agents. | BACKGROUND: A novel method for the prevention of bleeding after gastric endoscopic submucosal dissection (ESD) is necessary, as the numbers of patients taking antithrombotic agents have increased. This study aimed to assess the efficacy and safety of the covering method using polyglycolic acid (PGA) sheets and fibrin g... | ['Aged', 'Aged, 80 and over', 'Endoscopic Mucosal Resection', 'Female', 'Fibrin Tissue Adhesive', 'Fibrinolytic Agents', 'Humans', 'Male', 'Middle Aged', 'Polyglycolic Acid', 'Postoperative Hemorrhage', 'Stomach Neoplasms', 'Tissue Adhesives', 'Treatment Outcome'] | 29,357,012 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['E01.370.372.250.250.250', 'E01.370.388.250.250.250.230', 'E04.210.240.250.230', 'E04.502.250.250.250.230'], ['D12.776.124.270.305'], ['D27.505.519.421.750', 'D27.505.954.411.320', 'D27.505.954.502.427'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
[Ri plasmid transformation and metabolism of ginseng products on HepG2 cells]. | OBJECTIVE: To study the Ri plasmid transformation and metabolism of ginseng products on HepG2 cells.METHOD: The inhibitory effect of ginseng saponin on hepatoma HepG2 cells was studied. The hairy root-induced conditions were screened by orthogonal experimental design. The culture conditions were determined through hair... | ['Antineoplastic Agents', 'Cell Proliferation', 'Drugs, Chinese Herbal', 'Genetic Engineering', 'Hep G2 Cells', 'Humans', 'Panax', 'Plasmids', 'Saponins', 'Transformation, Genetic'] | 22,997,815 | [['D27.505.954.248'], ['G04.161.750', 'G07.345.249.410.750'], ['D20.215.784.500.350', 'D26.335'], ['E05.393.420'], ['A11.251.860.180.432', 'A11.436.348.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.650.940.800.575.912.250.087.500'], ['G05.360.600'], ['D09.408.782'], ['G05.728.865']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Fatal neonatal myocarditis caused by a recombinant human enterovirus-B variant. | We report a case of fatal myocarditis in a newborn infant who was infected with a human enterovirus detected by throat culture and RT-PCR for viral RNA in plasma. Whole genome sequence analysis revealed the virus to be a genomic chimera that likely arose from recombination between coxsackievirus B3 and two recently ide... | ['Enterovirus B, Human', 'Enterovirus Infections', 'Fatal Outcome', 'Genome, Viral', 'Humans', 'Infant, Newborn', 'Male', 'Molecular Sequence Data', 'Myocarditis', 'Pharynx', 'Plasma', 'RNA, Viral', 'Recombination, Genetic', 'Reverse Transcriptase Polymerase Chain Reaction', 'Sequence Analysis, DNA', 'Virus Cultivation... | 18,536,618 | [['B04.820.578.750.284.182'], ['C01.925.782.687.359'], ['E05.318.308.985.550.325', 'N01.224.935.698.201', 'N06.850.505.400.975.550.325', 'N06.850.520.308.985.550.325'], ['G05.360.340.358.840'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['L01.453.245.667'], ['C14.280.238.625'], ['A03.556.750'... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Named Groups [M]', 'Information Science [L]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Enhancement of activation of caspases by presenilin 1 gene mutations and its inhibition by secretase inhibitors. | Presenilin 1 (PS1) gene mutations are the major causes of early-onset familial Alzheimer's disease. Acceleration of apoptosis is one of the major pathogenic mechanisms of PS1 mutants, and PS1 mutants have also been reported to induce overproduction of amyloid-beta protein 42. Here, we investigated aberrancy in activati... | ['Alzheimer Disease', 'Amyloid Precursor Protein Secretases', 'Apoptosis', 'Caspase 3', 'Caspase 7', 'Caspase 8', 'Caspase 9', 'Caspases', 'Caspases, Initiator', 'Cell Line, Tumor', 'Enzyme Activation', 'Enzyme Inhibitors', 'Humans', 'Hydrogen Peroxide', 'Mutation', 'Neuroblastoma', 'Neurons', 'Oxidants', 'Presenilin-1... | 19,276,550 | [['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['D08.811.277.656.300.032'], ['G04.146.954.035'], ['D08.811.277.656.262.500.126.350.300', 'D08.811.277.656.300.200.126.350.300', 'D12.644.360.075.405.350.300', 'D12.776.476.075.405.350.300'], ['D08.811.277.656.262.500.126.350.700', 'D08.811.277.656.300.200... | ['Diseases [C]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cerebral bone subtraction CT angiography using 80 kVp and sinogram-affirmed iterative reconstruction: contrast medium and radiation dose reduction with improvement of image quality. | INTRODUCTION: The purpose of this study was to evaluate the feasibility of a contrast medium (CM), radiation dose reduction protocol for cerebral bone-subtraction CT angiography (BSCTA) using 80-kVp and sinogram-affirmed iterative reconstruction (SAFIRE).METHODS: Seventy-five patients who had undergone BSCTA under the ... | ['Aged', 'Computed Tomography Angiography', 'Contrast Media', 'Feasibility Studies', 'Female', 'Humans', 'Intracranial Aneurysm', 'Iopamidol', 'Male', 'Radiation Dosage', 'Radiographic Image Interpretation, Computer-Assisted', 'Retrospective Studies', 'Skull', 'Subtraction Technique'] | 28,050,639 | [['M01.060.116.100'], ['E01.370.350.350.810.335', 'E01.370.350.567.250', 'E01.370.350.600.350.700.810.335', 'E01.370.350.700.700.810.335', 'E01.370.350.700.810.810.568', 'E01.370.350.825.810.810.499'], ['D27.505.259.500', 'D27.720.259'], ['E05.318.372.550', 'E05.337.675', 'N05.715.360.330.550', 'N06.850.520.450.550'], ... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Polymorphous low-grade adenocarcinoma and adenoid cystic carcinoma: distinct architectural composition revealed by collagen IV, laminin and their integrin ligands (alpha2beta1 and alpha3beta1). | AIMS: Polymorphous low-grade adenocarcinoma (PLGA) and adenoid cystic carcinoma (ACC) are malignant salivary gland tumours bearing many similar histological patterns. This study was undertaken to show how the presence and distribution of collagen IV and laminin, and their ligands (integrin alpha2beta1 and alpha3beta1 c... | ['Adenocarcinoma', 'Carcinoma, Adenoid Cystic', 'Collagen', 'Diagnosis, Differential', 'Humans', 'Immunohistochemistry', 'Integrin alpha3beta1', 'Integrins', 'Laminin', 'Receptors, Collagen', 'Salivary Gland Neoplasms'] | 10,931,234 | [['C04.557.470.200.025'], ['C04.557.470.200.025.220'], ['D05.750.078.280', 'D12.776.860.300.250'], ['E01.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512', 'H01.158.201.344... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Ability of possible DMS precursors to release DMS during wine aging and in the conditions of heat-alkaline treatment. | The origin of dimethyl sulfide (DMS) produced during wine aging was examined through different assays. The production of DMS during the model aging of a wine and the concomitant decrease of residual potential DMS (PDMS), as DMS released by heat-alkaline treatment in 0.5 M sodium hydroxide at 100 degrees C for 1 h, were... | ['Dimethyl Sulfoxide', 'Fermentation', 'Food Handling', 'Hot Temperature', 'Hydrogen-Ion Concentration', 'Methionine', 'Reproducibility of Results', 'Sodium Hydroxide', 'Sulfides', 'Time Factors', 'Vitamin U', 'Wine', 'Yeasts'] | 15,796,605 | [['D02.886.640.150'], ['G02.111.158.249', 'G03.191.249'], ['J01.576.423.200'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.775.710.380', 'N06.230.300.100.725.232', 'N06.230.300.100.725.710.380'], ['G02.300'], ['D02.886.030.676', 'D12.125.142.557', 'D12.125.154.549', 'D12.125.166.676'], ['E05.318.370... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Selective carbonic anhydrase IX inhibitors based on coumarin scaffold as promising antimetastatic agents: WO2012070024. | Human carbonic anhydrase (hCA) IX is involved in tumorigenesis and metastasis through pathways modulating extracellular pH regulation and cell adhesion control. As a consequence, hCA IX represents a promising antitumor target for the development of new drugs in order to treat/image hypoxic cancers, and different agents... | ['Animals', 'Antigens, Neoplasm', 'Antineoplastic Agents', 'Carbonic Anhydrase IX', 'Carbonic Anhydrase Inhibitors', 'Carbonic Anhydrases', 'Cell Adhesion', 'Cell Hypoxia', 'Coumarins', 'Drug Design', 'Humans', 'Hydrogen-Ion Concentration', 'Mice', 'Molecular Targeted Therapy', 'Neoplasm Metastasis', 'Neoplasms', 'Pate... | 23,387,899 | [['B01.050'], ['D23.050.285'], ['D27.505.954.248'], ['D08.811.520.241.300.150.450', 'D12.776.543.178', 'D23.050.285.196'], ['D27.505.519.389.200'], ['D08.811.520.241.300.150'], ['G04.022'], ['G03.197.300', 'G04.270.300'], ['D03.383.663.283.446', 'D03.633.100.150.446'], ['E05.290.500', 'H01.158.703.007.338.500', 'H01.18... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 |
Identification of a new P1 residue mutation (444Arg----Ser) in a dysfunctional C1 inhibitor protein contained in a type II hereditary angioedema plasma. | A new reactive-centre P1 residue mutation (444Arg----Ser), has been identified in a dysfunctional C1 inhibitor protein, C1 inhibitor(Ba), contained in a type II hereditary angioedema plasma. This substitution is compatible with a point mutation of the 444Arg codon (CGC----AGC), and represents the first non-histidine, n... | ['Amino Acid Sequence', 'Angioedema', 'Base Sequence', 'Complement C1 Inactivator Proteins', 'Humans', 'Molecular Sequence Data', 'Mutation', 'Peptide Fragments', 'Trypsin'] | 2,365,061 | [['G02.111.570.060', 'L01.453.245.667.060'], ['C14.907.079', 'C17.800.862.945.066', 'C20.543.480.904.066'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D12.644.861.140', 'D12.776.124.486.274.920.250', 'D12.776.872.140'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.453.245.667'], ['G05.365.59... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Which patients are cured of breast cancer? | The clinical and pathological features of 51 patients who survived for more than 20 years after diagnosis of cancer of the breast were compared with those of 176 contemporaries who died within 20 years after diagnosis. Of those who survived, 18 (35%) had had pathologically affected axillary nodes compared with at least... | ['Adult', 'Age Factors', 'Aged', 'Axilla', 'Breast Neoplasms', 'Female', 'Follow-Up Studies', 'Humans', 'Lymphatic Metastasis', 'Middle Aged', 'Neoplasm Metastasis', 'Neoplasm Staging', 'Neoplasms, Multiple Primary', 'Prognosis', 'Time Factors'] | 6,435,795 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['A01.378.800.090'], ['C04.588.180', 'C17.800.090.500'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.697.650.560', 'C23.550.727.650.560'], ... | ['Named Groups [M]', 'Health Care [N]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Brain Lactate Concentration Falls in Response to Hypoglycemia in Patients With Type 1 Diabetes and Impaired Awareness of Hypoglycemia. | Brain lactate may be involved in the development of impaired awareness of hypoglycemia (IAH), a condition that affects approximately 25% of patients with type 1 diabetes and increases the risk of severe hypoglycemia. The aim of this study was to investigate the effect of acute hypoglycemia on brain lactate concentratio... | ['Adult', 'Awareness', 'Brain', 'Case-Control Studies', 'Diabetes Mellitus, Type 1', 'Female', 'Glucose Clamp Technique', 'Humans', 'Hypoglycemia', 'Insulin', 'Lactic Acid', 'Magnetic Resonance Spectroscopy', 'Male', 'Young Adult'] | 26,993,070 | [['M01.060.116'], ['F02.463.188.150'], ['A08.186.211'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['C18.452.394.750.124', 'C19.246.267', 'C20.111.327'], ['E01.370.225.124.100.350', 'E05.196.500', 'E05.200.124.100.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C18.452.394.... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Associations and interactions between lipid profiles, retinopathy and nephropathy in patients with type 1 diabetes: the FinnDiane Study. | OBJECTIVES: The aim of this study was to investigate the associations between lipid profiles and retinopathy in the large nationwide FinnDiane Study and to examine interactions and correlations between retinopathy, nephropathy and lipid variables.DESIGN AND SUBJECTS: A total of 1465 patients with type 1 diabetes, avail... | ['Adult', 'Cholesterol', 'Cholesterol, HDL', 'Cross-Sectional Studies', 'Diabetes Mellitus, Type 1', 'Diabetic Nephropathies', 'Diabetic Retinopathy', 'Female', 'Finland', 'Humans', 'Lipids', 'Logistic Models', 'Male', 'Risk Factors', 'Severity of Illness Index', 'Triglycerides'] | 23,844,944 | [['M01.060.116'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['D04.210.500.247.808.197.238', 'D10.532.432.400', 'D10.570.938.208.270', 'D12.776.521.479.470'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['C18.452.394.750.124', 'C19.246.267', 'C20.111.32... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Geographicals [Z]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Loss of Rab5 drives non-autonomous cell proliferation through TNF and Ras signaling in Drosophila. | Deregulation of the endocytic machinery has been implicated in human cancers. However, the mechanism by which endocytic defects drive cancer development remains to be clarified. Here, we find through a genetic screen in Drosophila that loss of Rab5, a protein required for early endocytic trafficking, drives non-autonom... | ['Animals', 'Animals, Genetically Modified', 'Cell Proliferation', 'Drosophila Proteins', 'Drosophila melanogaster', 'ErbB Receptors', 'Eye', 'GTP-Binding Proteins', 'Green Fluorescent Proteins', 'Humans', 'Imaginal Discs', 'Intracellular Signaling Peptides and Proteins', 'JNK Mitogen-Activated Protein Kinases', 'Membr... | 25,224,221 | [['B01.050'], ['B01.050.050.136', 'B05.620.136'], ['G04.161.750', 'G07.345.249.410.750'], ['D12.776.093.500.462'], ['B01.050.500.131.617.720.500.500.750.310.250.500'], ['D08.811.913.696.620.682.725.400.009', 'D12.776.543.750.630.009', 'D12.776.543.750.750.400.074'], ['A01.456.505.420', 'A09.371'], ['D08.811.277.040.330... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Balanced intakes of natural triglycerides for optimum nutrition: an evolutionary and phytochemical perspective. | Natural whole foods contain fats as structural components, and have a balance of polyunsaturated fat, monounsaturated fat, and saturated fat. Since we are still a Paleolithic species, adapted to eating only wild foods, it is difficult to justify the consumption of anything other than an overall balance of triglyceride/... | ['Animals', 'Arachidonic Acid', 'Biological Evolution', 'Diabetes Mellitus, Type 2', 'Dietary Fats', 'Dietary Fats, Unsaturated', 'Energy Metabolism', 'Fish Oils', 'Fishes', 'Hominidae', 'Humans', 'Meat', 'Nutritional Physiological Phenomena', 'Phospholipids', 'Time', 'Triglycerides'] | 9,293,470 | [['B01.050'], ['D10.251.355.255.100.100', 'D10.251.355.310.166.100'], ['G05.045', 'G16.075'], ['C18.452.394.750.149', 'C19.246.300'], ['D10.212.302', 'G07.203.300.375', 'J02.500.375'], ['D10.212.302.380', 'G07.203.300.375.400', 'J02.500.375.400'], ['G03.295'], ['D10.627.430'], ['B01.050.150.900.493'], ['B01.050.150.900... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
A clinical study of glass ionomer cement. | The aim of this investigation was to compare the clinical performance of a glass ionomer cement (GIC) with a composite resin when used for direct bonding of standard edgewise orthodontic brackets. Fourteen patients (10 females, four males), in whom 242 teeth were bonded with brackets, were divided into two groups: GIC ... | ['Acrylic Resins', 'Adolescent', 'Aluminum Silicates', 'Bisphenol A-Glycidyl Methacrylate', 'Child', 'Dental Bonding', 'Dental Stress Analysis', 'Female', 'Glass Ionomer Cements', 'Humans', 'Male', 'Materials Testing', 'Orthodontic Brackets', 'Orthodontic Wires', 'Resin Cements'] | 15,130,042 | [['D05.750.716.822.111', 'D25.720.716.822.111', 'J01.637.051.720.716.822.111'], ['M01.060.057'], ['D01.056.050.075', 'D01.578.725.025', 'D01.650.550.050.075', 'D01.837.725.700.760.050'], ['D02.241.081.069.600.150', 'D02.455.426.559.389.657.100', 'D05.750.716.822.308.200', 'D25.339.816.500.200', 'D25.720.716.822.308.200... | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 |
Effects of Intradiscal Injection of Local Anesthetics on Intervertebral Disc Degeneration in Rabbit Degenerated Intervertebral Disc. | Analgesic discoblock is widely used for the diagnosis or treatment of discogenic low back pain by injecting local anesthetics. The purpose of this study was to investigate the deleterious effects of local anesthetics on degenerated rabbit intervertebral disks (IVDs) using an organotypic culture model and in vivo long-t... | ['Anesthetics, Local', 'Animals', 'Bupivacaine', 'Disease Models, Animal', 'Intervertebral Disc', 'Intervertebral Disc Degeneration', 'Lidocaine', 'Nucleus Pulposus', 'Organ Culture Techniques', 'Rabbits'] | 31,106,893 | [['D27.505.696.277.100.200', 'D27.505.696.663.850.025', 'D27.505.954.427.210.100.200'], ['B01.050'], ['D02.065.199.239', 'D02.092.146.113.239'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['A02.165.308.410', 'A02.835.232.834.432', 'A10.165.382.350.050'], ['C05.116.900.153'], ['D02.065.199.092.500', 'D02.092.146.113... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A model of implant-associated infection in the tibial metaphysis of rats. | OBJECTIVE: Implant-associated infections remain serious complications in orthopaedic and trauma surgery. A main scientific focus has thus been drawn to the development of anti-infective implant coatings. Animal models of implant-associated infections are considered helpful in the in vivo testing of new anti-infective i... | ['Animals', 'Anti-Bacterial Agents', 'Biofilms', 'Coated Materials, Biocompatible', 'Disease Models, Animal', 'Female', 'Prostheses and Implants', 'Prosthesis-Related Infections', 'Rats', 'Rats, Sprague-Dawley', 'Staphylococcal Infections', 'Staphylococcus aureus', 'Tibia', 'Titanium'] | 24,381,519 | [['B01.050'], ['D27.505.954.122.085'], ['A20.593', 'G06.120'], ['D25.130.420', 'J01.637.051.130.420'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['E07.695'], ['C01.685', 'C23.550.767.868'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.750'], ['C01.150.252.410.868'], ['B03.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Ras-pathway has a dual role in yeast galactose metabolism. | In the yeast Saccharomyces cerevisiae the genes involved in galactose metabolism (GAL1,7,10) are transcriptionally activated more than a 1000-fold in the presence of galactose as the sole carbon source in the culture media. In the present work, we monitored the activity of the GAL10 gene promoter in different Ras-cAMP ... | ['Adenylyl Cyclases', 'Alleles', 'Galactose', 'Gene Deletion', 'Gene Expression', 'Gene Expression Regulation, Fungal', 'Genes, Reporter', 'Phenotype', 'Plasmids', 'Promoter Regions, Genetic', 'RNA, Messenger', 'Saccharomyces cerevisiae', 'Saccharomyces cerevisiae Proteins', 'ras Proteins', 'ras-GRF1'] | 17,475,260 | [['D08.811.520.650.200', 'D12.644.360.050', 'D12.776.476.050'], ['G05.360.340.024.340.030'], ['D09.947.875.359.377'], ['G05.365.590.762.320', 'G05.558.800.320'], ['G05.297'], ['G05.308.330'], ['G05.360.340.024.340.435'], ['G05.695'], ['G05.360.600'], ['G02.111.570.080.689.675', 'G05.360.080.689.675', 'G05.360.340.024.3... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Monitoring the Formation of Amyloid Oligomers Using Photoluminescence Anisotropy. | The formation of oligomeric soluble aggregates is related to the toxicity of amyloid peptides and proteins. In this manuscript, we report the use of a ruthenium polypyridyl complex ([Ru(bpy)2(dpqp)]2+) to track the formation of amyloid oligomers at different times using photoluminescence anisotropy. This technique is s... | ['Amyloid', 'Anisotropy', 'Luminescent Measurements', 'Photochemical Processes', 'Polymers', 'Ruthenium Compounds'] | 31,536,338 | [['D05.500.049', 'D12.776.049'], ['G01.590.040', 'G02.050'], ['E05.196.712.516'], ['G02.740'], ['D05.750', 'D25.720', 'J01.637.051.720'], ['D01.765']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
The relative radiosensitivity of TK6 and WI-L2-NS lymphoblastoid cells derived from a common source is primarily determined by their p53 mutational status. | The lymphoblastoid cell lines WI-L2-NS and TK6 were derived from a non-clonal pool of cells taken from a human spleen. Despite their common background they exhibit marked differences in radiosensitivities; D0 values of 93 and 67 cGy have been reported for WI-L2-NS and TK6 cells respectively. We show here that this diff... | ['Apoptosis', 'Base Sequence', 'Blotting, Western', 'Cell Line', 'DNA Damage', 'Dose-Response Relationship, Radiation', 'Gamma Rays', 'Humans', 'Lymphocytes', 'Molecular Sequence Data', 'Mutation', 'Polymerase Chain Reaction', 'Precipitin Tests', 'Radiation Tolerance', 'Sequence Analysis, DNA', 'Tumor Suppressor Protei... | 7,885,404 | [['G04.146.954.035'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['A11.251.210'], ['G05.200'], ['E05.799.513.500', 'G01.750.740.500', 'G04.712.500', 'G07.225', 'G07.738.500', 'N06.850.810.250.180'], ['G0... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
A piezoelectric quartz crystal impedance study on Cu(2+)-induced precipitation of bovine serum albumin in aqueous solution. | Piezoelectric quartz crystal impedance (QCI) technique was used for monitoring the Cu(2+)-induced precipitation of bovine serum albumin onto the gold electrode. The critical precipitate concentration of Cu(2+) reflected by the significant decrease in the resonant frequency was estimated to be 9.98 x 10(-5) mol x l(-1),... | ['Animals', 'Cattle', 'Chemical Precipitation', 'Copper', 'Crystallization', 'Electric Impedance', 'Electrodes', 'Gold', 'In Vitro Techniques', 'Quartz', 'Serum Albumin, Bovine', 'Solutions', 'Water'] | 11,245,892 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['E05.196.150', 'G02.159'], ['D01.268.556.195', 'D01.268.956.170', 'D01.552.544.195'], ['E05.196.300', 'G02.171'], ['G01.358.500.249.277.350'], ['E07.305.250'], ['D01.268.556.322', 'D01.268.956.186', 'D01.552.544.322'], ['E05.481'], ['D01.578.750.600', 'D01.650.550... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Use of dialectical behavior therapy in a partial hospital program for women with borderline personality disorder. | Dialectical behavior therapy, an outpatient psychosocial treatment for chronically suicidal women with borderline personality disorder, has been adapted for use in a partial hospital program for women. Patients attend the program for a minimum of five days of individual and group therapy, and full census is 12 women. A... | ['Adult', 'Aftercare', 'Behavior Therapy', 'Borderline Personality Disorder', 'Day Care, Medical', 'Female', 'Hospitals, Psychiatric', 'Humans', 'Middle Aged', 'Outpatient Clinics, Hospital', 'Psychotherapy, Brief', 'Rhode Island', 'Suicide', "Women's Health Services"] | 9,603,574 | [['M01.060.116'], ['E02.760.169.063', 'N02.421.585.169.063', 'N04.590.233.727.210.063'], ['F04.754.137'], ['F03.675.100'], ['E02.760.246', 'N02.421.585.246'], ['N02.278.421.556.508'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['N02.278.035.380', 'N02.278.216.500.968.527', 'N04.452.442.452.42... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Structure characterization and identification steroidal saponins from Ophiopogon japonicus Ker-Gawler (Liliaceae) by high-performance liquid chromatography with ion trap mass spectrometry. | INTRODUCTION: Steroidal saponins are the main active constituents in Ophiopogon japonicus Ker-Gawler (Liliaceae). However, because of their high polarity, non-chromophores and low content in plants, steroidal saponins are difficult to be isolated from O. japonicus by conventional phytochemical methods.OBJECTIVE: To dev... | ['China', 'Chromatography, High Pressure Liquid', 'Drugs, Chinese Herbal', 'Molecular Structure', 'Ophiopogon', 'Plant Extracts', 'Plant Roots', 'Saponins', 'Spectrometry, Mass, Electrospray Ionization', 'Steroids'] | 21,046,684 | [['Z01.252.474.164'], ['E05.196.181.400.300'], ['D20.215.784.500.350', 'D26.335'], ['G02.111.570', 'G02.466'], ['B01.650.940.800.575.912.250.618.100.060.600'], ['D20.215.784.500', 'D26.667'], ['A18.400'], ['D09.408.782'], ['E05.196.566.600'], ['D04.210.500']] | ['Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Relationship between dietary patterns and serum uric acid concentrations among ethnic Chinese adults in Taiwan. | The evidence for a relationship between dietary patterns and uric acid concentrations is scanty. Here, we used a validated food frequency questionnaire for an ethnic Chinese population in Taiwan to investigate the relationship between dietary patterns and uric acid concentrations. A cross-sectional study on 266 adults,... | ['Adult', 'Aged', 'Asian Continental Ancestry Group', 'Cross-Sectional Studies', 'Diet', 'Discriminant Analysis', 'Factor Analysis, Statistical', 'Female', 'Fruit', 'Humans', 'Hyperuricemia', 'Male', 'Middle Aged', 'Surveys and Questionnaires', 'Taiwan', 'Uric Acid', 'Vegetables'] | 22,507,614 | [['M01.060.116'], ['M01.060.116.100'], ['M01.686.508.200'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['G07.203.650.240'], ['E05.318.740.350', 'N05.715.360.750.325', 'N06.850.520.830.350'], ['E05.318.740.400', 'N05.715.360.750.350', 'N06.850.520.830.400'], ['A18.024.500', 'G07.203.3... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
L-dopa restores amplitude of growth hormone pulses in old male rats to that observed in young male rats. | 35 male Sprague-Dawley rats, 18 months old, were injected subcutaneously with the catecholamine precursor, L-dihydroxyphenylalanine (L-dopa) (100 mg/kg, twice daily), or vehicle alone, for 8 days in an attempt to increase the amplitude of growth hormone (GH) pulses in old male rats. 40% of young rats had at least one G... | ['Age Factors', 'Animals', 'Catecholamines', 'Growth Hormone', 'Hypothalamus', 'Levodopa', 'Male', 'Periodicity', 'Pituitary Gland', 'Pituitary Gland, Anterior', 'Rats', 'Somatostatin'] | 6,122,169 | [['N05.715.350.075', 'N06.850.490.250'], ['B01.050'], ['D02.092.311', 'D02.455.426.559.389.657.166.175'], ['D06.472.699.631.525.425', 'D12.644.548.691.525.425'], ['A08.186.211.180.497', 'A08.186.211.200.317.357'], ['D02.092.311.200.480', 'D02.455.426.559.389.657.166.175.200.480', 'D12.125.072.050.685.400.500', 'D12.125... | ['Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
CT angiography with volume rendering: advantages and applications in splanchnic vascular imaging. | The authors compared volume rendering with maximum intensity projection (MIP) and shaded surface display as a technique for generating three-dimensional (3D) images of the vasculature from spiral computed tomography (CT) data sets. In four patients with pathologic splanchnic vasculature, the advantages of volume-render... | ['Abdomen', 'Adult', 'Algorithms', 'Angiography', 'Carcinoma, Hepatocellular', 'Female', 'Hepatic Artery', 'Hepatic Veins', 'Humans', 'Image Processing, Computer-Assisted', 'Liver Neoplasms', 'Mesenteric Artery, Superior', 'Mesenteric Veins', 'Middle Aged', 'Pancreatic Neoplasms', 'Pancreatic Pseudocyst', 'Pancreatitis... | 8,685,358 | [['A01.923.047'], ['M01.060.116'], ['G17.035', 'L01.224.050'], ['E01.370.350.700.060', 'E01.370.370.050'], ['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['A07.015.114.407'], ['A07.015.908.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['C04.588.274.6... | ['Anatomy [A]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Subendocardial ischemic myocardial lesions associated with severe coronary atherosclerosis. | Morphologic changes in the subendocardial myocardium that appeared to be caused by severe, chronic subendocardial ischemia were studied in patients with fatal ischemic heart disease admitted to the Specialized Center of Research for Ischemic Heart Disease at the University of Alabama in Birmingham in the period 1970--1... | ['Aged', 'Aspartate Aminotransferases', 'Coronary Disease', 'Creatine Kinase', 'Electrocardiography', 'Female', 'Humans', 'L-Lactate Dehydrogenase', 'Male', 'Middle Aged', 'Myocardium', 'Myofibrils', 'Necrosis', 'Papillary Muscles', 'Sarcolemma'] | 7,361,850 | [['M01.060.116.100'], ['D08.811.913.477.700.225'], ['C14.280.647.250', 'C14.907.585.250'], ['D08.811.913.696.640.150'], ['E01.370.370.380.240', 'E01.370.405.240'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.682.047.551.400', 'D08.811.682.047.820.493'], ['M01.060.116.630'], ['A02.633.580', 'A07.541.704',... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Lineage specification of parietal epithelial cells requires â-catenin/Wnt signaling. | â-Catenin/Wnt signaling is essential during early inductive stages of kidney development, but its role during postinductive stages of nephron development and maturation is not well understood. In this study, we used Pax8Cre mice to target â-catenin deficiency to renal epithelial cells at the late S-shaped body stage an... | ['Animals', 'Cell Differentiation', 'Cell Lineage', 'Epithelial Cells', 'Kidney', 'Mice', 'Mice, Knockout', 'Organogenesis', 'Wnt Signaling Pathway', 'beta Catenin'] | 22,021,707 | [['B01.050'], ['G04.152'], ['G04.172', 'G07.345.500.325.180.500', 'G08.686.155', 'G08.686.784.170.104.249'], ['A11.436'], ['A05.810.453'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.136.500.500', 'B01.050.150.900.649.313.992.635.505.500.550.455', 'B01.050.150.900.649.313.992.635.505.500.800.500'], ['G07... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endogenous distribution of retinoids during normal development and teratogenesis in the mouse embryo. | We have analysed the endogenous retinoids present in whole mouse embryos from day 9 to day 14 of development and in individual components of the embryo at two stages, day 10.5 and day 13, by HPLC. We can only detect two retinoids, all-trans-RA (tRA) and all-trans-retinol (t-retinol), and t-retinol is 5-10-fold in exces... | ['Animals', 'Chromatography, High Pressure Liquid', 'Embryo, Mammalian', 'Mice', 'Receptors, Retinoic Acid', 'Retinoids', 'Teratogens', 'Tissue Distribution', 'Tretinoin'] | 7,780,180 | [['B01.050'], ['E05.196.181.400.300'], ['A16.254'], ['B01.050.150.900.649.313.992.635.505.500'], ['D12.776.826.701', 'D12.776.930.775'], ['D02.455.326.271.665.202.495', 'D02.455.426.392.368.367.379.249.700', 'D02.455.849.131.495', 'D23.767.261.700'], ['D27.888.569.864'], ['G03.787.917', 'G07.690.725.949'], ['D02.455.32... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Association between History of Dental Amalgam Fillings and Risk of Parkinson's Disease: A Population-Based Retrospective Cohort Study in Taiwan. | The impact of dental amalgam on the development of Parkinson's disease (PD) is still uncertain, although a positive association between dental amalgam and PD has been found in a few case-control studies. The patients with amalgam fillings restored between 2000 and 2008 were identified by using the National Health Insur... | ['Adult', 'Aged', 'Case-Control Studies', 'Dental Amalgam', 'Female', 'Humans', 'Male', 'Mercury', 'Middle Aged', 'Parkinson Disease, Secondary', 'Proportional Hazards Models', 'Risk Factors', 'Taiwan'] | 27,906,991 | [['M01.060.116'], ['M01.060.116.100'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['D25.339.208.291', 'J01.637.051.339.208.291'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.268.556.504', 'D01.268.956.437', 'D01.552.544.504'], ['M01.060.116.630'], ['C10.228.140.079.862.800... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
Adsorption behaviour of bulgur. | The aim of this research was to determine the adsorption behaviour of bulgur. Three different particle sizes (2<coarse<3.5, 1.6<medium<3.0, 0.5<fine<2.0 mm) of bulgur, purchased from market, were kept in nine different equilibrium levels of relative humidity (8.2-97.3%) at 20, 30 and 40 °C. The data obtained were evalu... | ['Adsorption', 'Particle Size', 'Triticum', 'Water'] | 26,575,716 | [['G01.030', 'G02.020'], ['G02.712'], ['B01.650.940.800.575.912.250.822.918'], ['D01.045.250.875', 'D01.248.497.158.459.650', 'D01.650.550.925']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Ventricular enlargement in multiple sclerosis: a comparison of three-dimensional and linear MRI estimates. | Atrophy of central white matter is related to irreversible clinical disability in multiple sclerosis (MS) and ventricular enlargement may be a sensitive marker of this tissue loss. Therapeutic trials in MS have provided MRI data for investigation of cerebral atrophy in MS. These studies use almost exclusively two-dimen... | ['Adult', 'Age Factors', 'Cerebral Ventricles', 'Cohort Studies', 'Female', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Multiple Sclerosis', 'Reproducibility of Results'] | 11,548,165 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['A08.186.211.140'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['M01.060.116.630'], ['C10.114.375.500', 'C10.314.350.500', 'C20.111.258.250.500'], ['E0... | ['Named Groups [M]', 'Health Care [N]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Isolation and characterization of the acetyl-CoA synthetase from Penicillium chrysogenum. Involvement of this enzyme in the biosynthesis of penicillins. | Acetyl-CoA synthetase (ACS) of Penicillium chrysogenum was purified to homogeneity (745-fold) from fungal cultures grown in a chemically defined medium containing acetate as the main carbon source. The enzyme showed maximal rate of catalysis when incubated in 50 mM HCl-Tris buffer, pH 8.0, at 37 degrees C. Under these ... | ['Acetate-CoA Ligase', 'Aspergillus nidulans', 'Chromatography, Affinity', 'Chromatography, Gel', 'Chromatography, High Pressure Liquid', 'Chromatography, Ion Exchange', 'Electrophoresis, Polyacrylamide Gel', 'Isoelectric Focusing', 'Kinetics', 'Molecular Weight', 'Penicillins', 'Penicillium chrysogenum', 'Thermodynami... | 1,347,531 | [['D08.811.464.267.500.200'], ['B01.300.381.081.420'], ['E05.196.181.400.170'], ['E05.196.181.400.250'], ['E05.196.181.400.300'], ['E05.196.181.400.383'], ['E05.196.401.402', 'E05.301.300.319'], ['E05.196.401.663', 'E05.301.300.663'], ['G01.374.661', 'G02.111.490'], ['G02.494'], ['D02.065.589.099.750', 'D02.886.108.750... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Condylar fractures of the mandible. II. a radiographic study of remodeling processes in the temporomandibular joint. | Remodeling processes in 76 temporomandibular joints were studied on radiographs from 67 individuals sustaining condylar fractures. The indivuduals were ranged into four age groups: 3-11, 12-15, 16-19, and larger than or equal to 20 years of age at the time of fracture. The radiographic examinations were to be performed... | ['Adolescent', 'Adult', 'Age Factors', 'Child', 'Child, Preschool', 'Humans', 'Mandibular Condyle', 'Mandibular Fractures', 'Radiography', 'Temporomandibular Joint', 'Wound Healing'] | 408,284 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.232.781.324.502.632.600', 'A14.521.632.600'], ['C10.900.300.284.500.400.255', 'C26.404.750.467.441', 'C26.915.300.425.500.400.255'], ['E01.370.350.7... | ['Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Size-conditional smolting and the response of Carmel River steelhead to two decades of conservation efforts. | Threshold effects are common in ecosystems and can generate counterintuitive outcomes in management interventions. A threshold effect proposed for steelhead trout (Oncorhynchus mykiss) is size-conditional smolting and marine survival. Steelhead are anadromous, maturing in the ocean but migrating to freshwater to spawn,... | ['Animals', 'California', 'Conservation of Natural Resources', 'Life Cycle Stages', 'Models, Theoretical', 'Oncorhynchus mykiss'] | 29,190,806 | [['B01.050'], ['Z01.107.567.875.580.200', 'Z01.107.567.875.760.200'], ['J01.256', 'N06.230.080'], ['B05.500', 'G07.345.500.550.500'], ['E05.599'], ['B01.050.150.900.493.817.750.825.580.600']] | ['Organisms [B]', 'Geographicals [Z]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
Morphology of the uvula in obstructive sleep apnea. | Alterations in pharyngeal structure and function are considered fundamental in the pathogenesis of obstructive sleep apnea (OSA). However, little is known about morphologic features of the pharynx in patients with OSA. We therefore studied the tissue composition of the uvula (midsagittal section) in patients with OSA, ... | ['Female', 'Humans', 'Male', 'Middle Aged', 'Palate, Soft', 'Sleep Apnea Syndromes', 'Uvula'] | 2,782,743 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['A14.549.617.780'], ['C08.618.085.852', 'C10.886.425.800.750'], ['A14.549.617.780.729']] | ['Organisms [B]', 'Named Groups [M]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Role of angiotensin-converting enzyme inhibitors and angiotensin-receptor blockers in the prevention of progression of renal disease. | Systemic hypertension is common in patients with acute as well as with chronic renal diseases. Hypertension is an important factor that contributes to the progression of renal failure. Cardiovascular disease is the leading cause of death and disability in patients with chronic renal failure and in those receiving renal... | ['Angiotensin Receptor Antagonists', 'Angiotensin-Converting Enzyme Inhibitors', 'Animals', 'Blood Pressure', 'Disease Progression', 'Humans', 'Hypertension', 'Kidney Diseases', 'Kidney Function Tests', 'Renin-Angiotensin System'] | 10,981,102 | [['D27.505.519.162'], ['D27.505.519.389.745.085'], ['B01.050'], ['E01.370.600.875.249', 'G09.330.380.076'], ['C23.550.291.656'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['C12.777.419', 'C13.351.968.419'], ['E01.370.390.400'], ['G03.820', 'G09.330.380.813']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Differential neutrophil activation before and after endotoxin infusion in enterally versus parenterally fed volunteers. | This study was done to determine whether or not increased susceptibility to infection seen in enterally versus parenterally fed patients was caused by altered neutrophil (PMN) responsiveness. To determine the differential effects of route of feeding on human PMN activation, plasma C3a levels, circulating PMN counts, PM... | ['Chemotaxis', 'Complement Activation', 'Complement C3', 'Endotoxins', 'Enteral Nutrition', 'Hydrocortisone', 'Infusions, Intravenous', 'Kinetics', 'Lactoferrin', 'Leukocyte Count', 'Leukotriene B4', 'Male', 'N-Formylmethionine Leucyl-Phenylalanine', 'Neutrophils', 'Parenteral Nutrition', 'Time Factors', 'Tumor Necrosi... | 2,847,338 | [['F01.145.113.780.500', 'F01.145.875.439.500.500', 'G04.198.424', 'G07.568.500.590.500', 'G11.427.410.568.850.500'], ['G12.274'], ['D12.776.124.050.140', 'D12.776.124.486.274.250'], ['D23.946.123.329'], ['E02.421.360', 'E02.642.500.360'], ['D04.210.500.745.745.654.600', 'D06.472.040.585.353.476', 'D06.472.040.585.478.... | ['Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The novel thymidylate synthase inhibitor trifluorothymidine (TFT) and TRAIL synergistically eradicate non-small cell lung cancer cells. | PURPOSE: TRAIL, a tumor selective anticancer agent, may be used for the treatment of non-small cell lung cancer (NSCLC). However, TRAIL resistance is frequently encountered. Here, the combined use of TRAIL with trifluorothymidine (TFT), a thymidylate synthase inhibitor, was examined for sensitizing NSCLC cells to TRAIL... | ['Antimetabolites', 'Antineoplastic Combined Chemotherapy Protocols', 'Apoptosis', 'Carcinoma, Non-Small-Cell Lung', 'Caspases', 'Cathepsin B', 'Cell Cycle', 'Cell Death', 'Cell Line, Tumor', 'Drug Synergism', 'Humans', 'Lung Neoplasms', 'RNA Interference', 'RNA, Small Interfering', 'TNF-Related Apoptosis-Inducing Liga... | 24,744,163 | [['D27.505.519.186', 'D27.888.569.042'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['G04.146.954.035'], ['C04.588.894.797.520.109.220.249', 'C08.381.540.140.500', 'C08.785.520.100.220.500'], ['D08.811.277.656.262.500.126', 'D08.811.277.656.300.200.126', 'D12.644.360.075.405', 'D12.776.476.075.405'], ['... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The mandibular septum: anatomical observations of the jowls in aging-implications for facial rejuvenation. | BACKGROUND: The following study was undertaken to address the following questions: (1) Why do soft tissues over the mandibular body appear to be tethered to the jaw, restricting inferior descent? (2) Why does characteristic surface anatomy appear as it does? (3) What is the anatomical basis of jowl fat?METHODS: Sixteen... | ['Aged', 'Aged, 80 and over', 'Aging', 'Cadaver', 'Cheek', 'Female', 'Humans', 'Male', 'Mandible', 'Rejuvenation'] | 18,349,664 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['G07.345.124'], ['C23.550.260.224'], ['A01.456.505.173', 'A14.194'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.232.781.324.502.632', 'A14.521.632'], ['E02.849']] | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Risk factors of breast cancer among women in eastern India: a tertiary hospital based case control study. | AIM: Breast cancer is one of the most common cancers of women in India with high fatality rate. Over a 1 year study period 105 consecutive biopsy or fine needle aspiration cytology confirmed breast cancer patients were interviewed by direct questionnaire method regarding risk factors attending Surgery and Radiotherapy ... | ['Adolescent', 'Adult', 'Age Factors', 'Breast Feeding', 'Breast Neoplasms', 'Case-Control Studies', 'Child', 'Female', 'Humans', 'India', 'Menarche', 'Menopause', 'Middle Aged', 'Prognosis', 'Risk Factors', 'Rural Population', 'Surveys and Questionnaires', 'Tertiary Care Centers', 'Young Adult'] | 23,244,094 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['F01.145.407.199', 'G07.203.650.195', 'G07.203.650.220.500.500', 'G07.203.650.353.199'], ['C04.588.180', 'C17.800.090.500'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['M01.060.406'], ['B01.050.150.900.649.3... | ['Named Groups [M]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Specific binding sites for proadrenomedullin N-terminal 20 peptide (PAMP) in the rat. | Adrenomedullin (AM), a potent and novel vasodilator 52-residue peptide originally isolated from pheochromocytoma, is processed from a precursor molecule (preproAM) in which another unique 20-residue sequence, termed proadrenomedullin N-terminal 20 peptide (PAMP), exists. Using [125I Tyr0] rat PAMP as a radioligand, we ... | ['Adenosine Triphosphate', 'Adrenal Gland Neoplasms', 'Adrenal Glands', 'Adrenomedullin', 'Animals', 'Aorta, Thoracic', 'Binding Sites', 'Binding, Competitive', 'Cell Membrane', 'Cells, Cultured', 'Cyclic AMP', 'Endothelins', 'GTP-Binding Proteins', "Guanosine 5'-O-(3-Thiotriphosphate)", 'Humans', 'Inositol 1,4,5-Trisp... | 8,770,930 | [['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['C04.588.322.078', 'C19.053.347', 'C19.344.078'], ['A06.300.071'], ['D06.472.699.077', 'D12.644.548.017'], ['B01.050'], ['A07.015.114.056.372'], ['G02.111.570.120'], ['E05.196.080', 'G02.111.084', 'G02.111.570.120.309'], ['A11.284.149'], [... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
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