Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Quantitative analysis of human platelet adhesions under a small-scale flow device. | To realize real-time evaluation of human platelet adhesions onto material surfaces with small volumes of human platelet suspensions, we developed an apparatus consisting of a modified cone and plate-type viscometer, combined with an upright epi-fluorescence microscope. The apparatus allowed real-time evaluation of plat... | ['Blood Platelets', 'Hemorheology', 'Humans', 'Materials Testing', 'Platelet Adhesiveness', 'Platelet Aggregation', 'Platelet Function Tests', 'Rheology'] | 20,420,611 | [['A11.118.188', 'A15.145.229.188'], ['E05.830.250', 'G09.188.370', 'G09.330.380.630'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.570'], ['G09.188.390.600.500', 'G09.188.670'], ['G09.188.370.687', 'G09.188.390.600.640'], ['E01.370.225.625.625', 'E05.200.625.625'], ['E05.830', 'H01.671.808']] | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Contribution of alpha- and beta-receptors to ketogenic and lipolytic effects of norepinephrine in humans. | To assess the effects of alpha- and beta-adrenergic-receptor activation on ketone body kinetics and lipolysis in humans, five groups of overnight-fasted subjects were studied. Group 1 (n = 7) received norepinephrine (NE) to activate alpha- and beta-receptors, resulting in plasma NE concentrations of 1.5 +/- 0.19 ng/ml;... | ['Adult', 'Fatty Acids, Nonesterified', 'Female', 'Glucagon', 'Humans', 'Insulin', 'Ketone Bodies', 'Kinetics', 'Lactates', 'Lipolysis', 'Male', 'Middle Aged', 'Norepinephrine', 'Phentolamine', 'Receptors, Adrenergic, alpha', 'Receptors, Adrenergic, beta', 'Reference Values'] | 2,538,376 | [['M01.060.116'], ['D10.251.310'], ['D06.472.699.587.730.500', 'D12.644.548.586.730.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D06.472.699.587.200.500.625', 'D12.644.548.586.200.500.625'], ['D02.522.585'], ['G01.374.661', 'G02.111.490'], ['D02.241.511.459'], ['G02.111.534', 'G03.458.500'], ['M01.060.116.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The endoplasmic reticulum-sarcoplasmic reticulum connection: distribution of endoplasmic reticulum markers in the sarcoplasmic reticulum of skeletal muscle fibers. | The skeletal muscle sarcoplasmic reticulum (SR) was investigated for the presence of well-known endoplasmic reticulum (ER) markers: the lumenal protein BiP and a group of membrane proteins recognized by an antibody raised against ER membrane vesicles. Western blots of SR fractions revealed the presence of BiP in fast- ... | ['Animals', 'Blotting, Western', 'Calcium-Binding Proteins', 'Calnexin', 'Carrier Proteins', 'Chickens', 'Endoplasmic Reticulum', 'Fluorescent Antibody Technique', 'Heat-Shock Proteins', 'Immunohistochemistry', 'Intracellular Membranes', 'Membrane Proteins', 'Molecular Chaperones', 'Rabbits', 'Sarcoplasmic Reticulum', ... | 1,631,100 | [['B01.050'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['D12.776.157.125'], ['D12.644.360.372.311', 'D12.776.157.125.412.311', 'D12.776.476.387.311', 'D12.776.503.295', 'D12.776.543.162'], ['D12.776.157'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.6... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Posttraumatic stress disorder and occupational performance: building resilience and fostering occupational adaptation. | Resilience and vulnerability refer to an individual's capacity to persevere in the face of adversity. Resiliency and vulnerability are distinctive personal characteristics influenced by environmental factors such as socio-cultural and institutional contexts. Resiliency and vulnerability are not absolute; they are psych... | ['Adaptation, Psychological', 'Humans', 'Occupational Therapy', 'Psychological Theory', 'Social Support', 'Stress Disorders, Post-Traumatic', 'Task Performance and Analysis'] | 21,248,418 | [['F01.058'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.760.169.063.500.489', 'E02.831.489', 'H02.010.500'], ['F02.739'], ['I01.880.853.500.600'], ['F03.950.750.500'], ['F02.784.412.846', 'F02.784.692.746', 'F02.808.600']] | ['Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
Endogenous somatostatin-like peptides of rat basophilic leukemia cells. | The tetradecapeptide somatostatin (SOM 14) and a 28-amino acid biosynthetic precursor (SOM 28) are constituents of diverse neuroendocrine tissues that are released by noxious stimuli from a subset of sensory nerve endings, and substantially modify the functions of basophils and mast cells. SOM-like factors were detecte... | ['Amino Acids', 'Animals', 'Basophils', 'Cell Line', 'Chromatography, Gel', 'Chromatography, High Pressure Liquid', 'Female', 'Histamine Release', 'Immunosuppressive Agents', 'Leukemia', 'Molecular Weight', 'Peptides', 'Rabbits', 'Radioimmunoassay', 'Rats', 'Somatostatin'] | 2,411,811 | [['D12.125'], ['B01.050'], ['A11.118.637.415.120', 'A11.627.340.120', 'A15.145.229.637.415.120', 'A15.382.490.315.120'], ['A11.251.210'], ['E05.196.181.400.250'], ['E05.196.181.400.300'], ['G12.350'], ['D27.505.696.477.656'], ['C04.557.337'], ['G02.494'], ['D12.644'], ['B01.050.150.900.649.313.968.700'], ['E01.370.384.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Ambulatory office organization for internal medicine resident medical education. | PURPOSE: Residents will most effectively learn about ambulatory, systems-based practice by working in highly functional ambulatory practices; however, systems experiences in ambulatory training are thought to be highly variable. The authors sought to determine the prevalence of functional-practice characteristics at cl... | ['Ambulatory Care', 'Humans', 'Internal Medicine', 'Internship and Residency', 'Specialization', 'United States'] | 20,978,423 | [['E02.760.106', 'N02.421.585.106'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H02.403.429'], ['I02.358.337.350.500', 'I02.358.399.350.750'], ['H02.811'], ['Z01.107.567.875']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 |
Neutralization of divergent HIV-1 isolates by conformation-dependent human antibodies to Gp120. | The spectrum of human immunodeficiency virus type 1 (HIV-1) isolates neutralized by antibodies from HIV-1-infected humans is broader than the spectrum of isolates neutralized by sera from animals immunized with purified gp120 subunits. This broader neutralization was due, in part, to the presence of antibodies to conse... | ['Amino Acid Sequence', 'Antibody Specificity', 'Epitopes', 'Gene Products, env', 'HIV Antibodies', 'HIV Envelope Protein gp120', 'HIV-1', 'Humans', 'In Vitro Techniques', 'Molecular Sequence Data', 'Neutralization Tests', 'Protein Conformation', 'Structure-Activity Relationship'] | 1,718,036 | [['G02.111.570.060', 'L01.453.245.667.060'], ['G12.100'], ['D23.050.550'], ['D12.776.775.320', 'D12.776.964.775.325', 'D12.776.964.970.880.325'], ['D12.776.124.486.485.114.254.150.440', 'D12.776.124.790.651.114.254.150.440', 'D12.776.377.715.548.114.254.150.440'], ['D12.776.964.775.325.164.249', 'D12.776.964.775.562.50... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Comparison of light microscopy, in situ hybridization and polymerase chain reaction for detection of human papillomavirus in histological tissue of cervical intraepithelial neoplasia. | The aims of the study were to estimate the prevalence of HPV infection in patients treated for high grade lesions of the cervix uteri (HG CIN), and to evaluate the validity of the histological criteria used for detection of HPV infection. The study comprised 203 women treated for HG CIN by laser conization. Forty-three... | ['Adult', 'Aged', 'Cervical Intraepithelial Neoplasia', 'Female', 'Humans', 'In Situ Hybridization', 'Microscopy', 'Middle Aged', 'Papillomaviridae', 'Papillomavirus Infections', 'Polymerase Chain Reaction', 'Prevalence', 'Sensitivity and Specificity', 'Tumor Virus Infections', 'Uterine Cervical Neoplasms'] | 9,113,073 | [['M01.060.116'], ['M01.060.116.100'], ['C04.557.470.200.240.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.620.670.325', 'E01.370.225.750.600.670.325', 'E05.200.500.620.670.325', 'E05.200.750.600.670.325', 'E05.393.661.475'], ['E01.370.350.515', 'E05.595', 'H01.671.617.562'], ['M01.060.116.6... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Diagnostic problems of evaluating vertebral metastasis from breast carcinoma with a higher degree of malignancy. | BACKGROUND: Bone metastases from breast carcinoma are frequently observed as postoperative pathologic conditions; however, in many cases, diagnosis and treatment are difficult. Although most diagnoses of bone metastases are made by plain radiography (X-P) or bone scintigraphy, the use of magnetic resonance imaging (MRI... | ['Adult', 'Aged', 'Aged, 80 and over', 'Breast Neoplasms', 'Carcinoma', 'Disease-Free Survival', 'Female', 'Humans', 'Lymphatic Metastasis', 'Magnetic Resonance Imaging', 'Menopause', 'Middle Aged', 'Radiography', 'Radionuclide Imaging', 'Sensitivity and Specificity', 'Spinal Neoplasms', 'Survival Rate'] | 10,223,573 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C04.588.180', 'C17.800.090.500'], ['C04.557.470.200'], ['E01.789.800.190', 'E05.318.740.998.300', 'N04.761.559.590.800.190', 'N05.715.360.575.575.800.190', 'N05.715.360.750.795.300', 'N06.850.520.830.998.300'], ['B01.050.150.900.649.313.988.400.112.400.4... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Long-term complications of continent cutaneous urinary diversion in adult spinal cord injured patients. | OBJECTIVE: To report the long-term complications of continent cutaneous urinary diversion(CCUD) in spinal cord injured(SCI) patients unable to perform intermittent self-catheterization(ISC) through the urethra.MATERIALS AND METHODS: Between July 2001 and January 2012, adult SCI patients with a neurogenic bladder who un... | ['Adult', 'Female', 'Follow-Up Studies', 'Humans', 'Kidney Function Tests', 'Male', 'Middle Aged', 'Postoperative Complications', 'Quality of Life', 'Retrospective Studies', 'Spinal Cord Injuries', 'Treatment Outcome', 'Urinary Bladder', 'Urinary Bladder, Overactive', 'Urinary Catheterization', 'Urinary Diversion', 'Ur... | 26,397,363 | [['M01.060.116'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.390.400'], ['M01.060.116.630'], ['C23.550.767'], ['I01.800', 'K01.752.400.750', 'N06.850.505.400.425.837'], ['E05.318.372.500.500.500', 'E05.318.372.500... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Ethnic differences in allele frequency of autoimmune-disease-associated SNPs. | Several multiple, large-scale, genetic studies on autoimmune-disease-associated SNPs have been reported recently: peptidylarginine deiminase type 4 (PADI4) in rheumatoid arthritis (RA); solute carrier family 22 members 4 and 5 (SLC22A4 and 5) in RA and Crohn's disease (CD); programmed cell death 1 (PDCD1) in systemic l... | ['African Continental Ancestry Group', 'Antigens, CD', 'Antigens, Surface', 'Apoptosis Regulatory Proteins', 'Asian Continental Ancestry Group', 'Autoimmune Diseases', 'European Continental Ancestry Group', 'Gene Frequency', 'Genetic Predisposition to Disease', 'Genetic Variation', 'Genotype', 'Haplotypes', 'Humans', '... | 15,883,854 | [['M01.686.508.100'], ['D23.050.301.264.035', 'D23.101.100.110'], ['D23.050.301'], ['D12.644.360.075', 'D12.776.476.075'], ['M01.686.508.200'], ['C20.111'], ['M01.686.508.400'], ['G05.330'], ['C23.550.291.687.500', 'G05.380.355'], ['G05.365'], ['G05.380'], ['G05.380.360'], ['B01.050.150.900.649.313.988.400.112.400.400'... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Study of the structural and electronic properties of valproic acid and new derivatives used as anticonvulsant agents. | The conformational and electronic characteristics of the polar O(9)?C(8)-X(10) moiety in the anticonvulsant valproic acid (Vpa) drug and some of their amides and ester derivatives are analyzed at the B3LYP level using the 6-31+G(d,p) and 6-311++G(d,p) 6d,10f basis sets. Exploring the delocalization of the electron dens... | ['Anticonvulsants', 'Electrons', 'Electroshock', 'Models, Molecular', 'Molecular Conformation', 'Structure-Activity Relationship', 'Valproic Acid'] | 21,309,610 | [['D27.505.954.427.080'], ['G01.249.335', 'G01.358.500.750'], ['E05.723.402.403', 'F04.669.224'], ['E05.599.595'], ['G02.111.570.820'], ['G02.111.830', 'G07.690.773.997'], ['D02.241.081.944.509.900', 'D10.251.400.895.593.900']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]'] | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Effect of long term therapy with captopril on dopplerographic parameters of intrarenal blood flow and renal function in patients with hypertension and diabetes]. | Effect of 9-12 month treatment with captopril on dopplerographic parameters of intrarenal blood flow and renal function was studied in 30 hypertensive diabetics without clinical signs of nephroangiopathy. There was an interrelationship between strict blood pressure (BP) control (average 24-hour BP below 135/83) and imp... | ['Adult', 'Angiotensin-Converting Enzyme Inhibitors', 'Blood Flow Velocity', 'Captopril', 'Diabetes Complications', 'Diabetic Retinopathy', 'Female', 'Humans', 'Hypertension', 'Kidney', 'Male', 'Middle Aged', 'Renal Artery', 'Time', 'Ultrasonography, Doppler'] | 12,494,206 | [['M01.060.116'], ['D27.505.519.389.745.085'], ['E01.370.370.130', 'G09.330.380.630.080'], ['D12.125.072.401.623.270'], ['C19.246.099'], ['C11.768.257', 'C14.907.320.382', 'C19.246.099.500.382'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['A05.810.453'], ['M01.060.116.630'], ['A07.015.114.745'],... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
M. tuberculosis intramembrane protease Rip1 controls transcription through three anti-sigma factor substrates. | Regulated intramembrane proteolysis (RIP) is a mechanism of transmembrane signal transduction that functions through intramembrane proteolysis of substrates. We previously reported that the RIP metalloprotease Rv2869c (Rip1) is a determinant of Mycobacterium tuberculosis (Mtb) cell envelope composition and virulence, b... | ['Amino Acid Sequence', 'Bacterial Proteins', 'Gene Expression Regulation, Bacterial', 'Membrane Proteins', 'Metalloproteases', 'Molecular Sequence Data', 'Mycobacterium tuberculosis', 'Sequence Alignment', 'Sigma Factor', 'Substrate Specificity', 'Transcription, Genetic'] | 20,545,848 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D12.776.097'], ['G05.308.300'], ['D12.776.543'], ['D08.811.277.656.675'], ['L01.453.245.667'], ['B03.510.024.962.500.702', 'B03.510.460.400.410.552.552.702'], ['E05.393.751'], ['D12.776.930.800'], ['G02.111.835'], ['G02.111.873', 'G05.297.700']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Vesicle targeting: timed release and specificity for leukocytes in mice by subcutaneous injection. | When unilamellar vesicles were administered subcutaneously in mice, the half-time for the destruction of the vesicles varied from 12 to 600 hours, depending on their composition. The vesicles tested consisted of distearoyl phosphatidylcholine, cholesterol, and certain sugar and amino-sugar derivatives of cholesterol. V... | ['Animals', 'Cholesterol', 'Endocytosis', 'Liposomes', 'Lysosomes', 'Metabolic Clearance Rate', 'Mice', 'Neutrophils', 'Phosphatidylcholines', 'Structure-Activity Relationship'] | 7,350,660 | [['B01.050'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['G04.417'], ['D25.479.517', 'D26.255.260.517', 'J01.637.051.479.517', 'J01.637.087.500.517'], ['A11.284.430.214.190.875.190.550'], ['E01.370.225.843', 'E05.200.843', 'G03.490', 'G07.690.595', 'G07.690.725.513'], ['B01.050.150.900.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Rotational action of the supraspinatus muscle on the shoulder joint. | The shoulder joint allows three-dimensional movement. In order to analyze the function of the muscles which act on the shoulder joint, three-dimensional movements, including rotation, must be considered. Among muscles participating in the shoulder joint movement, the supraspinatus muscle is known to have abduction and ... | ['Adult', 'Cadaver', 'Electric Stimulation', 'Electrodes, Implanted', 'Humans', 'Humerus', 'Magnetic Resonance Imaging', 'Male', 'Movement', 'Muscle, Skeletal', 'Posture', 'Range of Motion, Articular', 'Rotation', 'Shoulder Joint', 'Supine Position'] | 9,785,254 | [['M01.060.116'], ['C23.550.260.224'], ['E05.723.402'], ['E07.305.250.319', 'E07.695.202'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.232.087.090.400'], ['E01.370.350.825.500'], ['G07.568', 'G11.427.410'], ['A02.633.567', 'A10.690.552.500'], ['G11.427.695'], ['E01.370.600.700', 'G11.427.760'], ['G01.48... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Silk fibroin protein from mulberry and non-mulberry silkworms: cytotoxicity, biocompatibility and kinetics of L929 murine fibroblast adhesion. | Silks fibers and films fabricated from fibroin protein of domesticated mulberry silkworm cocoon have been traditionally utilized as sutures in surgery and recently as biomaterial films respectively. Here, we explore the possibility of application of silk fibroin protein from non-mulberry silkworm cocoon as a potential ... | ['Animals', 'Biocompatible Materials', 'Bombyx', 'Cell Adhesion', 'Cell Line', 'Fibroblasts', 'Fibroins', 'Flow Cytometry', 'Indicators and Reagents', 'Macrophages, Peritoneal', 'Microscopy, Electron, Scanning', 'Nitric Oxide', 'Silk', 'Tumor Necrosis Factor-alpha'] | 18,322,779 | [['B01.050'], ['D25.130', 'D27.720.102.130', 'J01.637.051.130'], ['B01.050.500.131.617.720.500.500.937.650.100'], ['G04.022'], ['A11.251.210'], ['A11.329.228'], ['D05.750.078.875.500', 'D12.776.093.750.500'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Development of the polysomnographic database on CD-ROM. | We have developed a polysomnographic database on CD-ROM. The data were obtained from 16 subjects with sleep apnea syndrome. The physiological signals include electroencephalogram, electromyogram, electrooculogram, invasive blood pressure, respiratory wave, oxygen saturation, and cardiac volume as measured by VEST metho... | ['Adult', 'Algorithms', 'CD-ROM', 'Databases, Factual', 'Humans', 'Male', 'Middle Aged', 'Nonlinear Dynamics', 'Polysomnography', 'Signal Processing, Computer-Assisted', 'Sleep Apnea Syndromes', 'Software'] | 10,459,681 | [['M01.060.116'], ['G17.035', 'L01.224.050'], ['J01.897.280.500.668.800.250.200', 'J01.897.280.500.898.800.250.200', 'L01.178.590.875.800.250.200', 'L01.178.820.090.668.800.250.200', 'L01.178.820.090.898.800.250.200', 'L01.224.230.260.115.475.600.325.750', 'L01.280.960.800.250.200'], ['L01.313.500.750.300.188.400', 'L0... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 |
PathPred: an enzyme-catalyzed metabolic pathway prediction server. | The KEGG RPAIR database is a collection of biochemical structure transformation patterns, called RDM patterns, and chemical structure alignments of substrate-product pairs (reactant pairs) in all known enzyme-catalyzed reactions taken from the Enzyme Nomenclature and the KEGG PATHWAY database. Here, we present PathPred... | ['Biocatalysis', 'Biosynthetic Pathways', 'Environmental Pollutants', 'Enzymes', 'Internet', 'Metabolic Networks and Pathways', 'Software'] | 20,435,670 | [['G02.111.086', 'G02.130.500', 'G03.105'], ['G02.111.098', 'G03.493.100'], ['D27.888.284'], ['D08.811'], ['L01.224.230.110.500'], ['G03.493'], ['L01.224.900']] | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Information Science [L]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Premature closure of prosthetic mitral valves as a consequence of gravity. | To determine the influence of gravity on premature closure of prosthetic mitral valves, we studied 17 patients in whom this phenomenon had been observed during routine examination. All patients were in atrial fibrillation and none had aortic incompetence. Patients were studied in multiple positions by means of simultan... | ['Atrial Fibrillation', 'Cineangiography', 'Echocardiography', 'Gravitation', 'Heart Valve Prosthesis', 'Humans', 'Mitral Valve', 'Phonocardiography', 'Posture'] | 7,083,324 | [['C14.280.067.198', 'C23.550.073.198'], ['E01.370.350.700.060.190', 'E01.370.370.050.190'], ['E01.370.350.130.750', 'E01.370.350.850.220', 'E01.370.370.380.220'], ['G01.060.350'], ['E07.695.310'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A07.541.510.507'], ['E01.370.370.380.400.500'], ['G11.427.695']] | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Childhood Ki-1 lymphoma. A report of two cases. | Two cases of childhood Ki-1 lymphoma occurred with the expression of Ki-1+/HLA-DR+/IL-2R+/EMA+/Leu-M1-/pan-T antigens-/pan-B antigens- in neoplastic cells. Patient 1 with nodular skin lesions expressed Leu-2a+ in the neoplastic cells and died 14 months later. Patient 2 with lymph node swelling and hepatosplenomegaly ex... | ['Child, Preschool', 'Diagnosis, Differential', 'Female', 'Histiocytic Sarcoma', 'Humans', 'Lymph Nodes', 'Lymphoma, Large B-Cell, Diffuse', 'Lymphoma, Non-Hodgkin', 'Male', 'Phenotype'] | 2,673,133 | [['M01.060.406.448'], ['E01.171'], ['C04.557.227.380', 'C15.604.250.390.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A10.549.400', 'A15.382.520.604.412'], ['C04.557.386.480.150.585', 'C15.604.515.569.480.150.585', 'C20.683.515.761.480.150.585'], ['C04.557.386.480', 'C15.604.515.569.480', 'C20.683.515.761.4... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Replication-competent, nonneuroinvasive genetically engineered herpes virus is highly effective in the treatment of therapy-resistant experimental human tumors. | A genetically engineered, nonneurotropic herpes simplex virus (R7020) with a proven safety profile in both animals and humans was found effective in the treatment of large xenotransplanted tumors arising from a radiation- and chemotherapy-resistant human epidermoid carcinoma and a hormone-refractory prostate adenocarci... | ['Adenocarcinoma', 'Animals', 'Carcinoma, Squamous Cell', 'Dose Fractionation, Radiation', 'Drug Resistance, Neoplasm', 'Gene Expression Regulation, Viral', 'Genes, p53', 'Genetic Engineering', 'Humans', 'Injections, Intralesional', 'Male', 'Mice', 'Mice, Nude', 'Prostatic Neoplasms', 'Radiation Tolerance', 'Simplexvir... | 10,232,586 | [['C04.557.470.200.025'], ['B01.050'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['E02.815.639.200'], ['G07.690.773.984.395'], ['G05.308.385'], ['G05.360.340.024.340.375.249.385', 'G05.360.340.024.340.415.400.385'], ['E05.393.420'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.267.530.430'], ['B01.0... | ['Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
miR-19 targets PTEN and mediates high mobility group protein B1(HMGB1)-induced proliferation and migration of human airway smooth muscle cells. | BACKGROUND: The abnormal proliferation and migration of airway smooth muscle (ASM) cells contributes to airway remodeling during asthma. MiR-19a has been demonstrated to promote cell proliferation and angiogenesis of several cancer types by regulating the PTEN/PI3K/AKT pathway. Our previous study has shown that High-mo... | ["3' Untranslated Regions", 'Airway Remodeling', 'Asthma', 'Bronchi', 'Cell Movement', 'Cell Proliferation', 'Cells, Cultured', 'HMGB1 Protein', 'Humans', 'MicroRNAs', 'Myocytes, Smooth Muscle', 'PTEN Phosphohydrolase', 'Proto-Oncogene Proteins c-akt', 'Signal Transduction'] | 31,247,032 | [['D13.444.735.544.875.880', 'D13.444.735.790.878.880', 'G05.360.340.024.220.880.880', 'G05.360.340.024.340.137.910.880'], ['C23.300.017', 'G09.772.029'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['A04.411.125'], ['G04.198', 'G07.568.500.180'], ['G04.161.750', 'G07.345.249.410.750'], ['... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Voluntary exposure to a toxin: the genetic influence on ethanol consumption. | Ethyl alcohol is a toxin that, when consumed at high levels, produces organ damage and death. One way to prevent or ameliorate this damage in humans is to reduce the exposure of organs to alcohol by reducing alcohol ingestion. Both the propensity to consume large volumes of alcohol and the susceptibility of human organ... | ['Alcohol Drinking', 'Animals', 'Brain', 'Ethanol', 'Gene Regulatory Networks', 'Genetic Predisposition to Disease', 'Humans', 'Male', 'Mice', 'Quantitative Trait, Heritable', 'RNA', 'Rats', 'Rats, Inbred Strains', 'Transcriptome'] | 29,196,862 | [['F01.145.317.269'], ['B01.050'], ['A08.186.211'], ['D02.033.375'], ['G05.360.080.689.360'], ['C23.550.291.687.500', 'G05.380.355'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649.313.992.635.505.500'], ['G05.420.720'], ['D13.444.735'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050... | ['Psychiatry and Psychology [F]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Aequorin luminescence-based assay for 5-hydroxytryptamine (serotonin) type 3 receptor characterization. | The classical electrophysiological method to measure the function of the 5-hydroxytryptamine (serotonin) type 3 (5-HT(3)) receptor, a cation-permeable ligand-gated ion channel, is time-consuming and not suitable for high-throughput screening. Therefore, we have optimized the conditions for a sensitive assay suitable to... | ['Aequorin', 'Calcium', 'Cells, Cultured', 'Humans', 'Imidazoles', 'Ligands', 'Luminescent Agents', 'Luminescent Measurements', 'Pyrazines', 'Receptors, Serotonin, 5-HT3', 'Reproducibility of Results', 'Sensitivity and Specificity', 'Transfection'] | 17,617,370 | [['D12.776.532.020'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['A11.251'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.383.129.308'], ['D27.720.470.480'], ['D27.720.470.410.505'], ['E05.196.712.516'], ['D03.383.679'], ['D12.776.157.530.400.400.100.700', 'D12.776.543.550.450.500.100.700', 'D12.... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Flavonoids in the leaves of Asclepias incarnata L. | Seven flavonoid compounds: quercelin 3-O-beta-galactopyranoside, 3-O-beta-glucopyranoside, 3-O-arabinoside, 3-O-beta-glucopyranosyl (1-->2)-beta-galactopyranoside, 3-O-beta-xylopyranosyl (1-->2)-beta-galactopyranoside, 3-O-alpha-rhamnopyranosyl (1-->2)-beta-galactopyranoside and kaempferol 3-beta-glucopyranoside were i... | ['Asclepias', 'Flavonoids', 'Plant Extracts', 'Plant Leaves'] | 15,080,595 | [['B01.650.940.800.575.912.250.456.500.153'], ['D03.383.663.283.266.450', 'D03.633.100.150.266.450'], ['D20.215.784.500', 'D26.667'], ['A18.024.812']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Utility of interferon-gamma ELISPOT assay responses in highly tuberculosis-exposed patients with advanced HIV infection in South Africa. | BACKGROUND: Interferon-gamma (IFN-gamma) ELISPOT assays incorporating Mycobacterium tuberculosis-specific antigens are useful in the diagnosis of tuberculosis (TB) or latent infection. However, their utility in patients with advanced HIV is unknown. We studied determinants of ELISPOT responses among patients with advan... | ['Adolescent', 'Adult', 'Antibodies, Bacterial', 'Antigens, Bacterial', 'Case-Control Studies', 'Enzyme-Linked Immunosorbent Assay', 'Female', 'HIV Infections', 'Humans', 'Interferon-gamma', 'Male', 'Middle Aged', 'Mycobacterium tuberculosis', 'Predictive Value of Tests', 'Reagent Kits, Diagnostic', 'Sensitivity and Sp... | 17,725,839 | [['M01.060.057'], ['M01.060.116'], ['D12.776.124.486.485.114.107', 'D12.776.124.790.651.114.125', 'D12.776.377.715.548.114.125'], ['D23.050.161'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', '... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Telomerase immortalized human amnion- and adipose-derived mesenchymal stem cells: maintenance of differentiation and immunomodulatory characteristics. | Cell banking of mesenchymal stem cells (SCs) from various human tissues has significantly increased the feasibility of SC-based therapies. Sources such as adipose tissue and amnion offer outstanding possibilities for allogeneic transplantation due to their high differentiation potential and their ability to modulate im... | ['Adipogenesis', 'Adipose Tissue', 'Alkaline Phosphatase', 'Amnion', 'Antigens, Surface', 'Cell Count', 'Cell Differentiation', 'Cell Line, Transformed', 'Cell Proliferation', 'Cell Shape', 'Humans', 'Immunologic Factors', 'Karyotyping', 'Leukocytes, Mononuclear', 'Mesenchymal Stem Cells', 'Neoplasms', 'Osteocalcin', '... | 19,125,642 | [['G04.152.149'], ['A10.165.114'], ['D08.811.277.352.650.035'], ['A10.615.284.277', 'A16.254.750.277'], ['D23.050.301'], ['E01.370.225.500.195', 'E05.200.500.195', 'E05.242.195', 'G04.140'], ['G04.152'], ['A11.251.210.172'], ['G04.161.750', 'G07.345.249.410.750'], ['G04.320'], ['B01.050.150.900.649.313.988.400.112.400.... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
ECTRIMS/EAN Guideline on the pharmacological treatment of people with multiple sclerosis. | BACKGROUND: Multiple sclerosis (MS) is a complex disease with new drugs becoming available in the past years. There is a need for a reference tool compiling current data to aid professionals in treatment decisions.OBJECTIVES: To develop an evidence-based clinical practice guideline for the pharmacological treatment of ... | ['Consensus', 'Evidence-Based Medicine', 'Humans', 'Immunologic Factors', 'Immunomodulation', 'Multiple Sclerosis', 'Practice Guidelines as Topic'] | 29,353,550 | [['F01.829.316.068', 'F02.463.785.373.433'], ['H02.249.750', 'H02.403.200.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.477'], ['E02.095.465', 'G12.535'], ['C10.114.375.500', 'C10.314.350.500', 'C20.111.258.250.500'], ['N04.761.700.350.650', 'N05.700.350.650']] | ['Psychiatry and Psychology [F]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Optimization of phenylacetic acid derivatives for CRTH2 and DP selective antagonism. | We have previously reported that optimization of a series of phenylacetic acid derivatives led to the discovery of CRTH2 and DP dual antagonists, such as AMG 009 and AMG 853. During the optimization process, we discovered that minor structural modifications also afforded potent and selective CRTH2 or DP antagonists. He... | ['Asthma', 'Chemistry, Pharmaceutical', 'Drug Design', 'Humans', 'Hypersensitivity', 'Inhibitory Concentration 50', 'Kinetics', 'Models, Chemical', 'Phenylacetates', 'Prostaglandin D2', 'Receptors, G-Protein-Coupled', 'Receptors, Immunologic', 'Receptors, Prostaglandin', 'Sulfonamides'] | 22,119,474 | [['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['H01.158.703.007', 'H01.181.466'], ['E05.290.500', 'H01.158.703.007.338.500', 'H01.181.466.338.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C20.543'], ['E05.940.350', 'G07.690.936.563'], ['G01.374.661', 'G02.111.490'], ['E05.599.49... | ['Diseases [C]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Upregulation of 5-HT2C receptors in hippocampus of pilocarpine-induced epileptic rats: antagonism by Bacopa monnieri. | Emotional disturbances, depressive mood, anxiety, aggressive behavior, and memory impairment are the common psychiatric features associated with temporal lobe epilepsy (TLE). The present study was carried out to investigate the role of Bacopa monnieri extract in hippocampus of pilocarpine-induced temporal lobe epilepti... | ['Animals', 'Anticonvulsants', 'Bacopa', 'Carbamazepine', 'Disease Models, Animal', 'Epilepsy', 'Ergolines', 'Hippocampus', 'Inositol 1,4,5-Trisphosphate', 'Male', 'Pilocarpine', 'Plant Preparations', 'Protein Binding', 'Radioligand Assay', 'Rats', 'Rats, Wistar', 'Receptor, Serotonin, 5-HT2C', 'Serotonin Antagonists',... | 19,700,373 | [['B01.050'], ['D27.505.954.427.080'], ['B01.650.940.800.575.912.250.583.700.080'], ['D03.633.300.240.127'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['C10.228.140.490'], ['D03.132.327.287', 'D03.633.400.439'], ['A08.186.211.180.405', 'A08.186.211.200.885.287.500.345'], ['D02.033.800.519.400.350', 'D09.853.519.40... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Dynamic contact angle cycling homogenizes heterogeneous surfaces. | In order to reduce restenosis, the necessity to develop the appropriate coating material of metallic stent is a challenge for biomedicine and scientific research over the past decade. Therefore, biodegradable copolymers of poly((R,S)-3,3 dimethylmalic acid) (PDMMLA) were prepared in order to develop a new coating exhib... | ['Hydrophobic and Hydrophilic Interactions', 'Polymers', 'Surface Properties', 'Water'] | 27,612,817 | [['G02.409'], ['D05.750', 'D25.720', 'J01.637.051.720'], ['G02.860'], ['D01.045.250.875', 'D01.248.497.158.459.650', 'D01.650.550.925']] | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Resistance of interleukin-6 to the extracellular inhibitory environment promotes axonal regeneration and functional recovery following spinal cord injury. | Interleukin-6 (IL)-6 was originally discovered as a factor that contributes to the secondary pathological and inflammatory response in the central nervous system (CNS) following injury. However, accumulating evidence suggests that IL-6 is also involved in functional and structural recovery following CNS injury by promo... | ['Animals', 'Axons', 'Biomarkers', 'Disease Models, Animal', 'GAP-43 Protein', 'Ganglia, Spinal', 'Gene Expression', 'Interleukin-6', 'Male', 'Myelin Proteins', 'Nerve Regeneration', 'Nogo Proteins', 'Nogo Receptor 1', 'Pyramidal Tracts', 'Rats', 'Recovery of Function', 'Spinal Cord Injuries'] | 28,075,461 | [['B01.050'], ['A08.675.542.145', 'A11.284.180.075', 'A11.671.137', 'A11.671.501.145'], ['D23.101'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['D12.776.395.550.400', 'D12.776.543.550.400', 'D12.776.631.400'], ['A08.340.390.340', 'A08.800.350.340', 'A08.800.800.720.725.350'], ['G05.297'], ['D12.644.276.374.465.224... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Primary hyperparathyroidism]. | Over the past 40 years primary hyperparathyroidism (PHP) has changed from a rare, severe disease of the bones and kidneys to a common disease with hypertension, peptic ulcer, pancreatitis, easy fatigue and proximal muscle weakness. We have during these 40 years examined one of the greatest group of patients with PHP. P... | ['Adult', 'Female', 'Humans', 'Hyperparathyroidism', 'Hypertension', 'Male', 'Parathyroid Hormone', 'Peptic Ulcer'] | 8,711,383 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C19.642.355'], ['C14.907.489'], ['D06.472.699.590', 'D12.644.548.587'], ['C06.405.469.275.800', 'C06.405.748.586']] | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Lemierre's syndrome: One rare disease-Two case studies. | WHAT IS KNOWN AND OBJECTIVE: Lemierre's syndrome is often misdiagnosed as a common cold or viral infection. Fusobacterium necrophorum is the most common causative organism. The recommended treatment regimen is 6 weeks of a beta-lactam antibiotic along with metronidazole.CASE DESCRIPTION: We present two cases of Lemierr... | ['Adult', 'Anti-Bacterial Agents', 'Female', 'Fusobacterium Infections', 'Fusobacterium necrophorum', 'Humans', 'Jugular Veins', 'Lemierre Syndrome', 'Male', 'Metronidazole', 'Rare Diseases', 'Thrombophlebitis', 'beta-Lactams'] | 30,484,880 | [['M01.060.116'], ['D27.505.954.122.085'], ['C01.150.252.400.388.350'], ['B03.370.250.400', 'B03.440.425.410.420.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A07.015.908.498'], ['C01.150.252.400.388.350.700', 'C07.550.174', 'C09.775.262', 'C14.907.355.830.925.770.500', 'C14.907.617.718.788.500', 'C14.907.9... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Transcripts of the multidrug resistance genes in chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum. | Homologues of the mammalian multidrug resistance gene have been identified in isolates and clones of Plasmodium falciparum and designated pfmdr1 and pfmdr2. Mutations in pfmdr1 have been associated with chloroquine resistance but confirmation could not be obtained in a genetic cross. We have examined the copy number an... | ['Animals', 'Blotting, Southern', 'Chloroquine', 'DNA, Protozoan', 'Drug Resistance', 'Gene Expression', 'Genes, Protozoan', 'Nucleic Acid Hybridization', 'Plasmodium falciparum', 'RNA Probes', 'RNA, Messenger', 'RNA, Protozoan', 'Transcription, Genetic'] | 8,446,468 | [['B01.050'], ['E05.196.401.114', 'E05.301.300.087', 'E05.601.150'], ['D03.633.100.810.050.180'], ['D13.444.308.442'], ['G07.690.773.984'], ['G05.297'], ['G05.360.340.024.340.396', 'G05.360.340.397.500'], ['E05.393.661', 'G02.111.611'], ['B01.043.075.380.611.561'], ['D13.444.600.723', 'D27.505.259.750.600.825', 'D27.72... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effect of Cognitive Behavioral Therapy and Peer Leadership on Suicidal Ideation of Adolescents in Bengkulu. | To determine the effects of cognitive behavioral therapy and peer leadership on suicidal ideation among adolescents in senior high school, this study design used quasiexperimental pre-post testing with control group. Participants (N = 86) were recruited by purposive sampling technique. Data were collected using the Bec... | ['Adolescent', 'Adolescent Behavior', 'Cognitive Behavioral Therapy', 'Female', 'Humans', 'Leadership', 'Male', 'Peer Group', 'Risk Factors', 'Statistics, Nonparametric', 'Suicidal Ideation'] | 31,192,709 | [['M01.060.057'], ['F01.145.022'], ['F04.754.137.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.752.609'], ['F01.829.316.483'], ['E05.318.740.600.800.725', 'N05.715.350.200.700', 'N05.715.360.750.625.700.700', 'N06.850.490.625.750', 'N06.850.520.830.600.800.725'], ['E05.318.740.995', 'N05.715.360.750.760... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Dumbbell-like Au-Fe3O4 nanoparticles as label for the preparation of electrochemical immunosensors. | In this work, we developed a novel kind of label based on dumbbell-like Au-Fe3O4 nanoparticles (NPs) for the preparation of electrochemical immunosensor for the detection of cancer biomarker prostate specific antigen (PSA). The signal amplification strategy, using the synergetic effect present in Au-Fe3O4 to increase t... | ['Biosensing Techniques', 'Conductometry', 'Equipment Design', 'Equipment Failure Analysis', 'Gold', 'Humans', 'Hydrogen Peroxide', 'Immunoassay', 'Magnetite Nanoparticles', 'Male', 'Particle Size', 'Prostate-Specific Antigen', 'Staining and Labeling'] | 20,708,918 | [['E05.601.043'], ['E05.196.922.500', 'E05.301.160'], ['E05.320'], ['E05.325.192'], ['D01.268.556.322', 'D01.268.956.186', 'D01.552.544.322'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.248.497.158.685.750.424', 'D01.339.431.374.424', 'D01.650.550.750.400', 'D02.389.338.253'], ['E05.478.566', 'E05.601.470']... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Long-term follow-up of Jensen procedures. | Jensen procedures were performed on 29 eyes of 26 patients with lateral rectus palsy between January 1972 and July 1985. The cases were reviewed retrospectively to assess efficacy of the procedure and long-term stability. The patients were evaluated preoperatively with prism cover test, versions, forced auctions, sacca... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Child', 'Child, Preschool', 'Diplopia', 'Electrooculography', 'Esotropia', 'Follow-Up Studies', 'Humans', 'Middle Aged', 'Oculomotor Muscles', 'Ophthalmologic Surgical Procedures', 'Retrospective Studies', 'Saccades', 'Vision, Binocular', 'Young Adult'] | 24,880,184 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['M01.060.406'], ['M01.060.406.448'], ['C10.597.751.941.339', 'C11.966.339', 'C23.888.592.763.941.339'], ['E01.370.380.230.285', 'E01.370.405.245.787.285'], ['C10.292.562.887.300', 'C11.590.810.400'], ['E05.318.372.500.750.249', 'N05.715.3... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Anti-antibody activity of a monoclonal macroglobulin. | A monoclonal macroglobulin from a patient with Waldenstr?m macroglobulinemia has been shown to have antiglobulin activity of a new type, namely, that of a true anti-antibody. The protein reacts with human, primate, and rabbit IgM and IgG, only when the target immunoglobulin is complexed to an antigen. The implications ... | ['Animals', 'Antibodies, Anti-Idiotypic', 'Antibody Formation', 'Antibody Specificity', 'Antigen-Antibody Complex', 'Antigen-Antibody Reactions', 'Chickens', 'Chromatography, Gel', 'Goats', 'Haplorhini', 'Humans', 'Immune Sera', 'Immunoassay', 'Immunoglobulin G', 'Immunoglobulins', 'Iodine Isotopes', 'Macroglobulins', ... | 5,001,397 | [['B01.050'], ['D12.776.124.486.485.114.071', 'D12.776.124.790.651.114.071', 'D12.776.377.715.548.114.071'], ['G12.450.050.370.250'], ['G12.100'], ['D12.776.124.486.485.114.257', 'D12.776.124.790.651.114.257', 'D12.776.377.715.548.114.257', 'D23.050.101'], ['G12.122'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.2... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The microsurgical treatment of cranio-orbital tumors assisted by intraoperative electrophysiologic monitoring and neuronavigation. | OBJECTIVE: Total resection of cranio-orbital tumors without any major complications is still a challenge for neurosurgeons. Intraoperative electrophysiologic monitoring and neuronavigational system have been widely used in microneurosurgery, but their effects during microsurgical treatment of cranio-orbital tumors warr... | ['Action Potentials', 'Adolescent', 'Adult', 'Aged', 'Child', 'Electromyography', 'Female', 'Glasgow Outcome Scale', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Microsurgery', 'Middle Aged', 'Monitoring, Intraoperative', 'Neuronavigation', 'Neurosurgical Procedures', 'Ocular Motility Disorders', 'Oculomotor Muscle... | 22,381,333 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.406'], ['E01.370.405.255', 'E01.370.530.255'], ['E05.318.308.940.968.875.260', 'E05.944.510', 'N04.452.859.564.800.260', 'N05.715.360.300.715.500.800.335'], ['B01.050.150.900.649.313.988.400.112.400.... | ['Phenomena and Processes [G]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Bilateral congenital radio-ulnar synostosis with hyperpronation--findings and surgical therapy]. | Congenital proximal synostoses of the ulna and radius do not require surgery in most of the cases, since the proximal synostosis can be sufficiently compensated by the wrist joint. In cases of considerable functional deficit, the synostosis has to be separated to enable re-ossification in a more advantageous position. ... | ['Child, Preschool', 'Female', 'Humans', 'Motor Skills', 'Postoperative Complications', 'Radiography', 'Radius', 'Range of Motion, Articular', 'Synostosis', 'Ulna', 'Wrist Joint'] | 9,746,874 | [['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.808.260'], ['C23.550.767'], ['E01.370.350.700'], ['A02.835.232.087.090.700'], ['E01.370.600.700', 'G11.427.760'], ['C05.116.099.370.894', 'C05.660.906', 'C16.131.621.906'], ['A02.835.232.087.090.850'], ['A02.835.583.405.930']] | ['Named Groups [M]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Nonmyeloablative conditioning followed by transplantation of genetically modified HLA-matched peripheral blood progenitor cells for hematologic malignancies in patients with acquired immunodeficiency syndrome. | To assess the safety and efficacy of nonmyeloablative allogeneic transplantation in patients with HIV infection, a clinical protocol was initiated in patients with refractory hematologic malignancies and concomitant HIV infection. The results from the first 2 patients are reported. The indications for transplantation w... | ['Acquired Immunodeficiency Syndrome', 'Acute Disease', 'Adult', 'Anti-Bacterial Agents', 'Antiretroviral Therapy, Highly Active', 'Cyclophosphamide', 'Cyclosporine', 'Feasibility Studies', 'Ganciclovir', 'Graft vs Host Disease', 'Hematopoietic Stem Cell Transplantation', 'Hodgkin Disease', 'Humans', 'Infection Control... | 11,781,257 | [['C01.221.250.875.040', 'C01.221.812.640.400.040', 'C01.778.640.400.040', 'C01.925.782.815.616.400.040', 'C01.925.813.400.040', 'C01.925.839.040', 'C20.673.480.040'], ['C23.550.291.125'], ['M01.060.116'], ['D27.505.954.122.085'], ['E02.319.310.075'], ['D02.455.526.728.650.730.243', 'D02.705.672.500.243'], ['D04.345.56... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The efficacy of a two-tiered trauma activation system at a level I trauma center. | BACKGROUND: By using current American College of Surgeons trauma center triage criteria, 52% of patients transported to our level I trauma center are discharged home from the emergency department (ED). Because the majority of our trauma transports were based solely on mechanism of injury, we instituted, in 1990, a two-... | ['Abdominal Injuries', 'Accidental Falls', 'Accidents, Traffic', 'Adult', 'California', 'Child', 'Humans', 'Injury Severity Score', 'Patient Care Team', 'Retrospective Studies', 'Trauma Centers', 'Triage', 'Workforce', 'Wounds and Injuries', 'Wounds, Penetrating'] | 19,820,592 | [['C26.017'], ['N06.850.135.122'], ['N06.850.135.392'], ['M01.060.116'], ['Z01.107.567.875.580.200', 'Z01.107.567.875.760.200'], ['M01.060.406'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.940.968.875.500', 'E05.944.600', 'N04.452.859.564.800.500', 'N05.715.360.300.715.500.800.400'], ['N04.590.715']... | ['Diseases [C]', 'Health Care [N]', 'Named Groups [M]', 'Geographicals [Z]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Whole blood versus plasma measurements of glutamate and alanine across the human myocardium. | Comparison of whole blood and plasma aorto-coronary sinus concentration differences of glutamate and alanine were made before, during and after coronary sinus pacing in seven patients with normal and six patients with stenotic coronary arteries. Mean differences between duplicate analyses were greater in whole blood th... | ['Adult', 'Aged', 'Alanine', 'Blood', 'Cardiac Pacing, Artificial', 'Coronary Disease', 'Female', 'Glutamates', 'Humans', 'Male', 'Middle Aged', 'Myocardium', 'Plasma', 'Sinus of Valsalva'] | 3,589,494 | [['M01.060.116'], ['M01.060.116.100'], ['D12.125.042'], ['A12.207.152', 'A15.145'], ['E02.331.200'], ['C14.280.647.250', 'C14.907.585.250'], ['D12.125.067.625', 'D12.125.119.409'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['A02.633.580', 'A07.541.704', 'A10.690.552.750'], ['A12.207.152.693'... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Medullary osteogenesis with platinum cathodes. | Studies of electrical stimulation of osteogenesis with stainless steel electrodes have previously established a dose-response relationship between current and bone growth. Examination of the effect of differing geometric current densities resulted in the conclusion that very little electrode surface area was involved i... | ['Animals', 'Electric Stimulation', 'Male', 'Osteogenesis', 'Platinum', 'Rabbits', 'Stainless Steel'] | 3,998,890 | [['B01.050'], ['E05.723.402'], ['G07.345.500.325.377.625.050.500.729', 'G11.427.578.050.500.729'], ['D01.268.556.690', 'D01.268.956.734', 'D01.552.544.690'], ['B01.050.150.900.649.313.968.700'], ['D01.490.800.900', 'D01.552.033.847.681', 'D25.058.807.681', 'J01.637.051.058.807.681']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Psychopathology is associated with dyspeptic symptom severity in primary care patients with a new episode of dyspepsia. | BACKGROUND: Personality and psychiatric disorders are reported to be more common in dyspeptic patients with severe complaints, but it remains unclear whether this association exists for patients with mild and moderate dyspepsia.AIM: To study the association between dyspeptic symptom severity and psychopathology, major ... | ['Adult', 'Age Factors', 'Aged', 'Depressive Disorder', 'Disease Progression', 'Dyspepsia', 'Female', 'Humans', 'Life Change Events', 'Male', 'Middle Aged', 'Netherlands', 'Primary Health Care', 'Severity of Illness Index', 'Somatoform Disorders', 'Statistics as Topic', 'Stress, Psychological', 'Surveys and Questionnai... | 19,053,982 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['F03.600.300'], ['C23.550.291.656'], ['C23.888.821.236'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.458.410'], ['M01.060.116.630'], ['Z01.542.651'], ['N04.590.233.727'], ['E05.318.308.980.438.475.456.500', 'N05.715.360.300.... | ['Named Groups [M]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
Mortality on the first day of life: trends, causes of death and avoidability in eight Brazilian Federative Units, between 2010 and 2015. | OBJECTIVE: to calculate mortality rates on the first day of life from 2010 to 2015 in eight Brazilian Federative Units providing better quality information, to assess associated factors and to classify deaths by underlying causes and avoidability.METHODS: this was a descriptive study; mortality rates were compared acco... | ['Adult', 'Brazil', 'Cause of Death', 'Delivery, Obstetric', 'Female', 'Humans', 'Infant, Extremely Premature', 'Infant, Low Birth Weight', 'Infant, Newborn', 'Live Birth', 'Male', 'Maternal Health Services', 'Perinatal Death', 'Perinatal Mortality', 'Pregnancy', 'Premature Birth', 'Respiratory Distress Syndrome, Newbo... | 30,785,573 | [['M01.060.116'], ['Z01.107.757.176'], ['E05.318.308.985.550.250', 'N01.224.935.698.100', 'N06.850.505.400.975.550.250', 'N06.850.520.308.985.550.250'], ['E04.520.252'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520.520.500'], ['M01.060.703.520.460'], ['M01.060.703.520'], ['G08.686.784.769.496.249'... | ['Named Groups [M]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Receptive field structure of burst and tonic firing in feline lateral geniculate nucleus. | There are two recognised modes of firing activity in thalamic cells, burst and tonic. A low-threshold (LT) burst (referred to from now on as 'burst') comprises a small number of high-frequency action potentials riding the peak of a LT Ca(2+) spike which is preceded by a silent hyperpolarised state > 50 ms. This is trad... | ['Acetylcholine', 'Anesthesia', 'Anesthetics', 'Animals', 'Cats', 'Electroencephalography', 'Evoked Potentials, Visual', 'Geniculate Bodies', 'Photic Stimulation', 'Thalamic Nuclei', 'Visual Fields', 'Visual Pathways'] | 12,972,624 | [['D02.092.211.111'], ['E03.155'], ['D27.505.696.277.100', 'D27.505.954.427.210.100'], ['B01.050'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['E01.370.376.300', 'E01.370.405.245'], ['G07.265.216.500.425', 'G11.561.200.500.425', 'G14.330'], ['A08.186.211.200.317.826.701.444'], ['E05.723.729'], ['A08.186.211.200.... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The use of expert practice to explore reflection. | This article describes an experience, drawn from clinical practice, which has been used to expand personal knowledge and enable self-reflection. Johns' (1995) model of structured reflection provides an analysis of the practice experience. Carper's (1978) four ways of knowing is used to discuss personal learning and dev... | ['Bandages', 'Education, Nursing', 'Female', 'Humans', 'Leadership', 'Leg Ulcer', 'Nurse-Patient Relations', 'Nursing', 'Teaching', 'Thinking', 'United Kingdom'] | 15,974,547 | [['E07.101'], ['I02.358.462'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.752.609'], ['C17.800.893.592'], ['F01.829.401.650.600', 'N05.300.660.560'], ['H02.478', 'N04.452.758.377'], ['I02.903'], ['F02.463.785'], ['Z01.542.363']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 |
Classic Kaposi's sarcoma: a case report. | A 60-year-old male from the Mediterranean area presented with edematous right leg and livid nodules and macules on the skin of upper and lower extremities. Biopsy specimen obtained from the right upper leg showed a pathohistologic finding indicative of Kaposi's sarcoma. Polymerase chain reaction testing revealed HHV-8 ... | ['Herpesvirus 8, Human', 'Humans', 'Male', 'Middle Aged', 'Sarcoma, Kaposi', 'Skin', 'Skin Neoplasms'] | 15,788,143 | [['B04.280.210.400.700.330', 'B04.280.382.400.700.330', 'B04.613.204.500.700.330'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C01.925.256.466.860', 'C04.557.450.795.850', 'C04.557.645.750'], ['A17.815'], ['C04.588.805', 'C17.800.882']] | ['Organisms [B]', 'Named Groups [M]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Transcriptome analysis of responses to bluetongue virus infection in Aedes albopictus cells. | BACKGROUND: Bluetongue virus (BTV) causes a disease among wild and domesticated ruminants which is not contagious, but which is transmitted by biting midges of the Culicoides species. BTV can induce an intense cytopathic effect (CPE) in mammalian cells after infection, although Culicoides- or mosquito-derived cell cult... | ['Aedes', 'Animals', 'Bluetongue virus', 'Case-Control Studies', 'Cell Line', 'Gene Expression Profiling', 'Gene Expression Regulation', 'Gene Regulatory Networks', 'Insect Proteins', 'Mosquito Vectors', 'Sequence Analysis, RNA'] | 31,182,015 | [['B01.050.500.131.617.720.500.500.750.712.500.875.100'], ['B01.050'], ['B04.820.223.719.550.100'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['A11.251.210'], ['E05.393.332'], ['G05.308'], ['G05.360.080.689.360'], ['D12.776.093.500'], ['N06.850.335.188.100.500.500', 'N06.850.520.203... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Effects of hydroxylamine on the consequences of long-lasting administration of morphine in mice. II. Time course of the hydroxylamine effect on morphine tolerance. | Mice injected for 35 days with morphine sulfate in increasing doses did not show tolerance to the analgesic effects of morphine if injected intracranially with 0.3 M hydroxylamine. The excitatory action of morphine was unaffected. The interference with tolerance lasted for at least six weeks following the hydroxylamine... | ['Animals', 'Body Weight', 'Brain Chemistry', 'Drug Tolerance', 'Hydroxylamines', 'In Vitro Techniques', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Morphine', 'Motor Activity', 'Nerve Tissue Proteins', 'Reaction Time', 'Time Factors'] | 1,164,089 | [['B01.050'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['G02.111.150', 'G03.185'], ['G07.690.773.992'], ['D02.092.570'], ['E05.481'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Comparison of detection methods for heteroresistant vancomycin-intermediate Staphylococcus aureus, with the population analysis profile method as the reference method. | Staphylococcus aureus clinical isolates with vancomycin MICs of 2 ìg/ml have been associated with vancomycin therapeutic failure and the heteroresistant vancomycin-intermediate S. aureus (hVISA) phenotype. A population analysis profile (PAP) with an area under the curve (AUC) ratio of ? 0.9 for the AUC of the clinical ... | ['Anti-Bacterial Agents', 'Culture Media', 'Humans', 'Microbial Sensitivity Tests', 'Sensitivity and Specificity', 'Staphylococcus aureus', 'Vancomycin', 'Vancomycin Resistance'] | 21,048,008 | [['D27.505.954.122.085'], ['D27.720.470.305', 'E07.206'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.875.595', 'E05.200.875.595', 'E05.337.550.400'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700', 'N05.715.360.750.725', 'N06.850.520.445.800', 'N06.850.520.830.872'], ['B03.3... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[Electroluminescent device based on rare earth terbium complex]. | Rare earth complex TbY(m-MBA)6 (phen)2.2H20 have been synthesized, which were used as emitting materials in electroluminescence. Single-layer devices and bilayer devices with Alq as electron transmission layer have been fabricated. The electroluminescent properties of the devices were studied. The electroluminescent me... | ['Electrochemical Techniques', 'Energy Transfer', 'Luminescence', 'Luminescent Measurements', 'Molecular Structure', 'Organometallic Compounds', 'Polyvinyls', 'Spectrometry, Fluorescence', 'Terbium'] | 16,201,352 | [['E05.301'], ['G01.154.240', 'G02.111.255', 'G02.216'], ['G01.358.500.505.650.665', 'G01.590.540.665', 'G01.750.250.650.665', 'G01.750.770.578.665'], ['E05.196.712.516'], ['G02.111.570', 'G02.466'], ['D02.691'], ['D02.455.326.271.665.616', 'D02.455.326.271.884.533', 'D05.750.716.721', 'D25.720.716.721', 'J01.637.051.7... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Reconstitution of cholera toxin-activated adenylate cyclase. | Reconstitution of adenylate cyclase activity responsive to stimulation by guanylyl-5'imidodiphosphate or NaF may be achieved by mixing dilute Lubrol 12A9-solubilized extracts of wild-type S49 membranes with membranes of an adenylate cyclase-deficient variant. Experiments using N-ethylmaleimide to inactivate components ... | ['Adenylyl Cyclase Inhibitors', 'Adenylyl Cyclases', 'Binding Sites', 'Cell Line', 'Cholera Toxin', 'Enzyme Activation', 'Ethylmaleimide', 'Fluorides', 'Guanosine Triphosphate', 'Guanylyl Imidodiphosphate', 'Macromolecular Substances', 'Mutation'] | 277,913 | [['D27.505.519.389.108'], ['D08.811.520.650.200', 'D12.644.360.050', 'D12.776.476.050'], ['G02.111.570.120'], ['A11.251.210'], ['D08.811.913.400.725.115.180', 'D23.946.123.194', 'D23.946.330.150'], ['G02.111.263', 'G03.328'], ['D02.241.081.337.502.524.418', 'D02.478.440.418', 'D03.383.129.578.399.418'], ['D01.248.497.1... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Socioeconomic deprivation and cortical morphology: psychological, social, and biological determinants of ill health study. | OBJECTIVE: Neighborhood-level socioeconomic deprivation has been associated with poor cognitive function pertaining to language and the executive control. Few studies have explored the cortical morphology of regions most commonly associated with these functions. The aim of this study was to examine the association betw... | ['Adult', 'Biomarkers', 'Brain Mapping', 'Cardiovascular Diseases', 'Cerebral Cortex', 'Child', 'Cross-Sectional Studies', 'Executive Function', 'Female', 'Health Status Disparities', 'Humans', 'Inflammation', 'Language', 'Magnetic Resonance Imaging', 'Male', 'Metabolic Diseases', 'Middle Aged', 'Multivariate Analysis'... | 23,975,946 | [['M01.060.116'], ['D23.101'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['C14'], ['A08.186.211.200.885.287.500'], ['M01.060.406'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['F02.463.217'], ['I01.240.425.675', 'N01.224.425.437', 'N06.850.505.400.425... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Information Science [L]', 'Geograph... | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
Biologic properties of cell lines derived from canine mammary carcinomas. | Six canine mammary tumor cell lines (5 epithelial, 1 myoepithelial) were established from dogs with spontaneous mammary carcinomas. The cells were characterized for features of morphology and growth patterns on plastic, ultrastructure, cloning efficiency in soft agar, tumorigenicity in athymic nude mice, and hormonal r... | ['Animals', 'Cell Line', 'Culture Media', 'Dog Diseases', 'Dogs', 'Female', 'Mammary Glands, Animal', 'Mice', 'Mice, Nude', 'Neoplasms', 'Receptors, Estrogen', 'Receptors, Progesterone'] | 3,462,415 | [['B01.050'], ['A11.251.210'], ['D27.720.470.305', 'E07.206'], ['C22.268'], ['B01.050.150.900.649.313.750.250.216.200'], ['A10.336.482', 'A13.589'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.150.900.649.313.992.635.505.500.550.500'], ['C04'], ['D12.776.826.750.350', 'D12.776.930.778.350'], ['D12.776.826.75... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Rapid exclusion of chromosomal aneuploidies by fluorescence in situ hybridization prior to fetal surgery for obstructive uropathy--a case report. | Ultrasound of a fetus at 17 weeks gestation revealed posterior urethral valve syndrome with anhydramnios. Fluorescence in situ hybridization (FISH) to detect aneuploidies of chromosomes 13, 18, 21, X and Y was performed on transitional cells from the fetal bladder obtained at percutaneous vesicocentesis, followed by co... | ['Adult', 'Amniotic Fluid', 'Anastomosis, Surgical', 'Aneuploidy', 'Female', 'Fetal Diseases', 'Fetus', 'Humans', 'In Situ Hybridization, Fluorescence', 'Karyotyping', 'Male', 'Oligohydramnios', 'Pregnancy', 'Ultrasonography, Prenatal', 'Urinary Bladder', 'Urologic Diseases'] | 7,818,786 | [['M01.060.116'], ['A12.098', 'A16.378.149'], ['E04.035'], ['C23.550.210.050', 'G05.365.590.175.050', 'G05.700.131'], ['C13.703.277', 'C16.300'], ['A16.378'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.620.670.325.350', 'E01.370.225.750.600.670.325.350', 'E05.200.500.620.670.325.350', 'E05.200.7... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Implementing a bar-code assisted medication administration system: effects on the dispensing process and user perceptions. | PURPOSE: We assessed the effects of a bar-code assisted medication administration system used without the support of computerised prescribing (stand-alone BCMA), on the dispensing process and its users.METHODS: The stand-alone BCMA system was implemented in one ward of a teaching hospital. The number of dispensing step... | ['Attitude of Health Personnel', 'Drug Labeling', 'Electronic Data Processing', 'Health Plan Implementation', 'Humans', 'Medication Errors', 'Medication Systems, Hospital', 'Perception', 'Pharmaceutical Preparations', 'Safety Management'] | 24,717,725 | [['F01.100.050', 'N05.300.100'], ['E05.916.310', 'J01.576.655.750.321.400', 'J01.576.761.300.400'], ['L01.224.085'], ['N03.349.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.529', 'N02.421.450.500'], ['N04.452.442.452.675', 'N04.452.528.473'], ['F02.463.593'], ['D26'], ['N04.452.871.900', 'N06.850.13... | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 |
Dietary nitrate accelerates postexercise muscle metabolic recovery and O2 delivery in hypoxia. | We tested the hypothesis that the time constants (ô) of postexercise T2* MRI signal intensity (an index of O2 delivery) and muscle [PCr] (an index of metabolic perturbation, measured by (31)P-MRS) in hypoxia would be accelerated after dietary nitrate (NO3 (-)) supplementation. In a double-blind crossover design, eight ... | ['Adenosine Triphosphate', 'Administration, Oral', 'Adolescent', 'Adult', 'Beta vulgaris', 'Beverages', 'Biomarkers', 'Cross-Over Studies', 'Diet', 'Double-Blind Method', 'Energy Metabolism', 'England', 'Female', 'Humans', 'Hypoxia', 'Kinetics', 'Magnetic Resonance Imaging', 'Magnetic Resonance Spectroscopy', 'Male', '... | 25,301,896 | [['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['E02.319.267.100'], ['M01.060.057'], ['M01.060.116'], ['B01.650.940.800.575.912.250.200.399'], ['G07.203.100', 'J02.200'], ['D23.101'], ['E05.318.370.150', 'N05.715.360.325.150', 'N06.850.520.445.150'], ['G07.203.650.240'], ['E05.318.370.3... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Geographicals [Z]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
Diffusion model for ultrasound-modulated light. | Researchers use ultrasound (US) to modulate diffusive light in a highly scattering medium like tissue. This paper analyzes the US-optical interaction in the scattering medium and derives an expression for the US-modulated optical radiance. The diffusion approximation to the radiative transport equation is employed to d... | ['Computer Simulation', 'Diffusion', 'Light', 'Models, Theoretical', 'Phantoms, Imaging', 'Scattering, Radiation', 'Ultrasonics'] | 24,638,247 | [['L01.224.160'], ['G01.202', 'G02.196'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['E05.599'], ['E07.671'], ['E05.196.822', 'G01.867'], ['H01.671.031.849']] | ['Information Science [L]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
From trial and error to trial simulation. Part 2: an appraisal of current beliefs in the design and analysis of clinical trials for antidepressant drugs. | Study design factors are partly to blame for the high failure rate in trials with antidepressant drugs. Clinical trial simulation (CTS) allows the investigation of the influence of design characteristics on important aspects of clinical trials such as power and type I error. Using CTS scenarios, we evaluated the impact... | ['Antidepressive Agents', 'Attitude of Health Personnel', 'Clinical Trials as Topic', 'Computer Simulation', 'Depressive Disorder', 'Endpoint Determination', 'Guidelines as Topic', 'Humans', 'Models, Theoretical', 'Personnel Selection', 'Research Subjects'] | 19,675,543 | [['D27.505.954.427.700.122'], ['F01.100.050', 'N05.300.100'], ['E05.318.372.250.250', 'N05.715.360.330.250.250', 'N06.850.520.450.250.250'], ['L01.224.160'], ['F03.600.300'], ['E05.315'], ['N04.761.700.350', 'N05.700.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599'], ['N04.452.677.500'], ['M01.774']] | ['Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
[Familial myeloproliferative syndrome]. | The case histories of three patients with hematologic disorders are reviewed. The patients are members of the same family composed of three brothers and two sisters. Two have osteomyelofibrosis and one essential thrombocythemia. Hematologic, enzymatic, cytogenetic, immunocytologic and immunogenetic investigations allow... | ['Aged', 'Alleles', 'Bone Marrow', 'Chromosome Aberrations', 'Chromosome Disorders', 'Female', 'HLA Antigens', 'Humans', 'Karyotyping', 'Liver', 'Male', 'Middle Aged', 'Myeloproliferative Disorders'] | 6,701,501 | [['M01.060.116.100'], ['G05.360.340.024.340.030'], ['A15.382.216'], ['C23.550.210', 'G05.365.590.175'], ['C16.131.260', 'C16.320.180'], ['D23.050.301.500.450', 'D23.050.705.552.450'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.385.315', 'E05.200.500.385.315', 'E05.242.385.315', 'E05.393.285.475'... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Antiproliferative function of glia maturation factor beta. | Recombinant human glia maturation factor beta (GMF-beta) reversibly inhibits the proliferation of neoplastic cells in culture by arresting the cells in the G0/G1 phase. This phenomenon is not target-cell specific, as neural and nonneural cells are equally inhibited. When tested simultaneously, GMF-beta suppresses the m... | ['Animals', 'Astrocytes', 'Cell Cycle', 'Cell Division', 'Cell Line', 'Cells, Cultured', 'Drug Synergism', 'Fibroblast Growth Factor 1', 'Glia Maturation Factor', 'Growth Inhibitors', 'Kinetics', 'Nerve Tissue Proteins', 'Recombinant Proteins', 'Schwann Cells'] | 1,712,235 | [['B01.050'], ['A08.637.200', 'A11.650.200'], ['G04.144'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.251.210'], ['A11.251'], ['G07.690.773.968.477'], ['D12.644.276.624.110', 'D12.776.467.624.110', 'D23.529.624.110'], ['D12.644.276.860.325', 'D12.776.467.860.325', 'D12.776.631.600.3... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Inhibition of microtubule assembly by phosphorylation of microtubule-associated proteins. | 32P labeling of microtubular protein by endogenous protein kinase activity is shown to result from a net increase in protein-bound phosphate and is not the result of a phosphate exchange reaction between ATP and phosphoprotein. Protein phosphorylation is maximal in the presence of 0.5 mM Mg2+ and 0.25 mM ATP, resulting... | ['Animals', 'Brain', 'Guanosine Triphosphate', 'Kinetics', 'Microscopy, Electron', 'Microtubule-Associated Proteins', 'Microtubules', 'Phosphorylation', 'Protein Kinases', 'Proteins', 'Swine'] | 7,387,985 | [['B01.050'], ['A08.186.211'], ['D03.633.100.759.646.454.504', 'D13.695.667.454.504', 'D13.695.827.426.504'], ['G01.374.661', 'G02.111.490'], ['E01.370.350.515.402', 'E05.595.402'], ['D12.776.220.600.450', 'D12.776.631.560'], ['A11.284.430.214.190.750.602'], ['G02.111.665', 'G02.607.780', 'G03.796'], ['D08.811.913.696.... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Ventricular repolarization lability in children with Kawasaki disease. | Kawasaki disease (KD) is an acute febrile disease of unknown etiology that develops in children and is sometimes accompanied by myocardial dysfunction and systemic vasculitis. However, myocardial repolarization lability has not yet been fully investigated. Thus, the objective of this study was to evaluate myocardial re... | ['C-Reactive Protein', 'Child, Preschool', 'Electrocardiography', 'Female', 'Follow-Up Studies', 'Heart Rate', 'Humans', 'Male', 'Mucocutaneous Lymph Node Syndrome', 'Prognosis', 'Severity of Illness Index'] | 21,344,290 | [['D12.776.034.145', 'D12.776.124.050.120', 'D12.776.124.486.157'], ['M01.060.406.448'], ['E01.370.370.380.240', 'E01.370.405.240'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['E01.370.600.875.500', 'G09.330.380.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The black bag. | In the early- to mid-twentieth century, stories about nursing practice submitted by nurses frequently appeared in Public Health Nursing. The article reprinted here is an example of this genre of publications. Originally published in April 1936, this article tells the story of a day in the work of one public health nurs... | ['History, 20th Century', 'Humans', 'Narration', 'Nurses', 'Public Health Nursing'] | 23,078,428 | [['K01.400.504.968'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.502', 'F01.145.209.459', 'L01.399.250.660', 'N05.715.360.300.480', 'N06.850.520.308.502'], ['M01.526.485.650', 'N02.360.650'], ['H02.478.676.755']] | ['Humanities [K]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Information Science [L]', 'Health Care [N]', 'Named Groups [M]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 |
Functional and hemodynamic cardiac determinants of exercise capacity in patients with systolic heart failure. | Decreased exercise capacity is the main symptom in patients with heart failure (HF). We assessed the association among noninvasively determined maximal cardiac output at exercise, systolic and diastolic cardiac functions at rest, and peak oxygen uptake (pVo(2)) exercise capacity in patients with congestive HF. We studi... | ['Age Factors', 'Aged', 'Analysis of Variance', 'Cardiac Output', 'Chi-Square Distribution', 'Double-Blind Method', 'Exercise Test', 'Exercise Tolerance', 'Heart Failure, Systolic', 'Heart Rate', 'Hemodynamics', 'Humans', 'Linear Models', 'Male', 'Middle Aged', 'Predictive Value of Tests', 'Prognosis', 'Prospective Stu... | 22,818,784 | [['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['E01.370.370.380.150', 'G09.330.380.124'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.3... | ['Health Care [N]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Analysing public preferences for cancer screening programmes. | Economic evaluations generally fail to incorporate elements of intangible costs and benefits, such as anxiety and discomfort associated with the screening test and diagnostic test, as well as the magnitude of utility associated with a reduction in the risk of dying from cancer. In the present analysis, 750 respondents ... | ['Breast Neoplasms', 'Choice Behavior', 'Colorectal Neoplasms', 'Consumer Behavior', 'Cost-Benefit Analysis', 'Denmark', 'Female', 'Financing, Personal', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Interviews as Topic', 'Male', 'Mammography', 'Mass Screening', 'Middle Aged', 'Motivation', 'Stochastic Processes'... | 11,747,045 | [['C04.588.180', 'C17.800.090.500'], ['F02.463.785.373.346'], ['C04.588.274.476.411.307', 'C06.301.371.411.307', 'C06.405.249.411.307', 'C06.405.469.158.356', 'C06.405.469.491.307', 'C06.405.469.860.180'], ['F01.145.236'], ['N03.219.151.125'], ['Z01.542.816.124'], ['N03.219.559'], ['F01.100.150.500', 'N05.300.150.410']... | ['Diseases [C]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Geographicals [Z]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Named Groups [M]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
The molecular basis of tamoxifen induction of mouse uterine epithelial cell proliferation. | Tamoxifen, a selective estrogen modulator (SERM) that has found clinical utility in the treatment of breast cancer, is an antagonist in the breast and an agonist in the uterus. These agonist actions in the uterus lead to an increased risk of endometrial cancer. In this study in mice we have analyzed the mechanism of ac... | ['Animals', 'CDC2-CDC28 Kinases', 'Cell Cycle', 'Cells, Cultured', 'Cyclin A', 'Cyclin D1', 'Cyclin E', 'Cyclin-Dependent Kinase 2', 'DNA', 'Dose-Response Relationship, Drug', 'Epithelial Cells', 'Female', 'Immunohistochemistry', 'Mice', 'Mice, Inbred Strains', 'Phosphorylation', 'Selective Estrogen Receptor Modulators... | 15,642,790 | [['B01.050'], ['D08.811.913.696.620.682.700.646.500.500', 'D12.644.360.250.067', 'D12.776.167.200.067', 'D12.776.476.250.067'], ['G04.144'], ['A11.251'], ['D12.644.360.262.100', 'D12.776.167.218.100', 'D12.776.476.262.100'], ['D12.644.360.262.150.100', 'D12.776.167.218.150.100', 'D12.776.476.262.150.100', 'D12.776.624.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
A clinical evaluation of the Accutracker--a lightweight ambulatory blood pressure monitor. | An evaluation of the 'Accutracker', a new lightweight ambulatory blood pressure monitor, has been carried out in 14 subjects. Using a cross-over study design, BP readings obtained by the monitor were compared with BP measurements carried out in the opposite arm by a random zero sphygmomanometer. Both the systolic and d... | ['Adult', 'Aged', 'Aged, 80 and over', 'Blood Pressure Monitors', 'Evaluation Studies as Topic', 'Humans', 'Middle Aged', 'Reproducibility of Results'] | 2,607,520 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E07.230.740.100'], ['E05.337', 'N05.715.360.335'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Imaging of CA IX with fluorescent labelled sulfonamides distinguishes hypoxic and (re)-oxygenated cells in a xenograft tumour model. | BACKGROUND AND PURPOSE: Carbonic anhydrase (CA) IX is suggested to be an endogenous marker of hypoxia. Fluorescent sulfonamides with a high affinity for CA IX (CAI) have been developed and shown to bind to cells only when CA IX protein was expressed and while cells were hypoxic. The aim of this study was to investigate... | ['Animals', 'Antigens, Neoplasm', 'Binding Sites', 'Biomarkers, Tumor', 'Carbonic Anhydrase IX', 'Carbonic Anhydrases', 'Cell Hypoxia', 'Colorectal Neoplasms', 'Disease Models, Animal', 'Female', 'Fluorescent Antibody Technique', 'Mice', 'Mice, Nude', 'Neoplasm Transplantation', 'Oxygen', 'Oxygen Consumption', 'Probabi... | 19,616,332 | [['B01.050'], ['D23.050.285'], ['G02.111.570.120'], ['D23.101.140'], ['D08.811.520.241.300.150.450', 'D12.776.543.178', 'D23.050.285.196'], ['D08.811.520.241.300.150'], ['G03.197.300', 'G04.270.300'], ['C04.588.274.476.411.307', 'C06.301.371.411.307', 'C06.405.249.411.307', 'C06.405.469.158.356', 'C06.405.469.491.307',... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Satb1 and Satb2 are dispensable for X chromosome inactivation in mice. | Satb1 and Satb2 have been recently described as regulators of embryonic stem (ES) cell pluripotency and as silencing factors in X chromosome inactivation. The influence of the pluripotency machinery on X chromosome inactivation and the lack of an X chromosome inactivation defect in Satb1(-/-) and Satb2(-/-) mice raise ... | ['Animals', 'Female', 'Fibroblasts', 'Matrix Attachment Region Binding Proteins', 'Mice', 'Transcription Factors', 'X Chromosome Inactivation'] | 23,079,603 | [['B01.050'], ['A11.329.228'], ['D12.776.260.532'], ['B01.050.150.900.649.313.992.635.505.500'], ['D12.776.930'], ['G05.308.203.249.970']] | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Biomechanical properties of elastase treated palmar aponeuroses. | Human palmar aponeurosis was treated with elastase in the presence or absence of soybean trypsin inhibitor. The removal of elastic fibers was complete as proved by electron microscopy. Cyclic loading was performed at a constant strain rate. Residual strain was measured and the stiffness and the fraction of dissipated e... | ['Adult', 'Aged', 'Biomechanical Phenomena', 'Elasticity', 'Female', 'Hand', 'Humans', 'Male', 'Microscopy, Electron', 'Middle Aged', 'Pancreatic Elastase', 'Tendons', 'Trypsin Inhibitors', 'Viscosity'] | 2,060,309 | [['M01.060.116'], ['M01.060.116.100'], ['G01.154.090', 'G01.374.089'], ['G01.374.590'], ['A01.378.800.667'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.515.402', 'E05.595.402'], ['M01.060.116.630'], ['D08.811.277.656.300.760.560', 'D08.811.277.656.959.350.560'], ['A02.880'], ['D27.505.519.389.745.80... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Design, sythesis and evaluation of a series of 3- or 4-alkoxy substituted phenoxy derivatives as PPARs agonists. | Peroxisome proliferators-activated receptors (PPARá, ã and ä) are potentially effective targets for Type 2 diabetes mellitus therapy. The severe effects of known glitazones and the successfully approved agents (saroglitazar and lobeglitazone) motivated us to study novelly potent PPARs drugs with improved safety profile... | ['Drug Design', 'Hypoglycemic Agents', 'Molecular Docking Simulation', 'Peroxisome Proliferator-Activated Receptors', 'Thiazolidinediones'] | 28,186,999 | [['E05.290.500', 'H01.158.703.007.338.500', 'H01.181.466.338.500'], ['D27.505.696.422'], ['E05.599.595.249', 'L01.224.160.249'], ['D12.776.826.239', 'D12.776.930.705'], ['D02.886.675.933', 'D03.383.129.708.933']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Information Science [L]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
[Bromocriptine in Parkinsonian syndromes. Results obtained in a group of patients treated for 8 months]. | Antiparkinsonian treatment with L-Dopa gives rise to a number of problems: I) lack of initial response in a few cases; II) side-effects; III) becoming less effective after the first few years of treatment. Consequently, various drugs have been tried to replace, or combine with, L-Dopa. Among those drugs bromocriptine h... | ['Aged', 'Bromocriptine', 'Carbidopa', 'Drug Evaluation', 'Female', 'Humans', 'Levodopa', 'Male', 'Middle Aged', 'Parkinson Disease', 'Time Factors'] | 752,907 | [['M01.060.116.100'], ['D03.132.327.412.100', 'D03.633.400.439.131', 'D03.633.400.562.100'], ['D02.092.311.200.538.200', 'D02.442.200', 'D02.455.426.559.389.657.166.175.200.538.200'], ['E05.290.625', 'E05.337.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.092.311.200.480', 'D02.455.426.559.389.657.166.17... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Presence of HPV DNA in placenta and cervix of pregnant Mexican women. | PURPOSE: To identify the presence of HPV DNA in cervical as well as in placental tissue of pregnant Mexican women and to determine which type is more frequent.METHODS: In a cross-sectional study, 56 placental samples were obtained from 72 pregnant women. HPV DNA was extracted and amplified with polymerase chain reactio... | ['Adolescent', 'Adult', 'Cervix Uteri', 'Cross-Sectional Studies', 'DNA, Viral', 'Female', 'Humans', 'Mexico', 'Papillomavirus Infections', 'Placenta', 'Pregnancy', 'Pregnancy Outcome', 'Young Adult'] | 21,538,009 | [['M01.060.057'], ['M01.060.116'], ['A05.360.319.679.256'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['D13.444.308.568'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.107.567.589'], ['C01.925.256.650', 'C01.925.928.725'], ['A16.710'], ['G08.686.784.769'], ['E01.789.700', ... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Geographicals [Z]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Surgical options in the treatment of ulcerative colitis and Crohn's colitis. | The surgical standard for ulcerative colitis was complete proctocolectomy. Colectomy with mucosal proctectomy reduces the problems of the perineal wound essentially. A conventional ileostomy can be avoided by Kock's pouch technique. Correct operative technique reduces the complications with necessary reoperation to 10-... | ['Colectomy', 'Colitis', 'Colitis, Ulcerative', 'Crohn Disease', 'Humans', 'Ileostomy', 'Postoperative Complications', 'Prognosis', 'Reoperation'] | 3,387,971 | [['E04.210.219'], ['C06.405.205.265', 'C06.405.469.158.188'], ['C06.405.205.265.231', 'C06.405.205.731.249', 'C06.405.469.158.188.231', 'C06.405.469.432.249'], ['C06.405.205.731.500', 'C06.405.469.432.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.210.338.508', 'E04.579.338.508'], ['C23.550.767'], ['E01.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Measurement of drug facilitated sexual assault agents in simulated sweat by ion mobility spectrometry. | Ion mobility spectrometry has found widespread use for the detection of explosives and illicit drugs. The technique offers rapid results with high sensitivity and little sample preparation. As such, it is well suited for field deployed screening settings. Here the response of ion mobility spectrometers for three drug-f... | ['Flunitrazepam', 'Forensic Toxicology', 'Humans', 'Ketamine', 'Models, Biological', 'N-Methyl-3,4-methylenedioxyamphetamine', 'Psychotropic Drugs', 'Sensitivity and Specificity', 'Sex Offenses', 'Spectrophotometry, Atomic', 'Substance Abuse Detection', 'Sweat'] | 23,598,140 | [['D03.633.100.079.080.070.320'], ['H01.158.891.424', 'H02.884.424', 'I01.198.780.968'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.455.426.392.368.367.652'], ['E05.599.395'], ['D02.092.471.683.152.670'], ['D27.505.954.427.700'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700', 'N05.... | ['Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 |
Simian Plasmodium knowlesi malaria: studies of coagulation and pathology. | Uniformly fatal simian malaria was induced in ten rhesus monkeys by injection of Plasmodium knowlesi. The results of serial studies of platelet and blood coagulation factor levels suggested the occurrence of intravascular coagulation during the last 48 hours of the disease, concurrent with a marked fall in hematocrit l... | ['Animals', 'Blood Coagulation Disorders', 'Blood Platelets', 'Factor V', 'Factor VIII', 'Fibrin Fibrinogen Degradation Products', 'Fibrinogen', 'Haplorhini', 'Hematocrit', 'Macaca mulatta', 'Malaria', 'Plasmodium', 'Prothrombin'] | 811,125 | [['B01.050'], ['C15.378.100'], ['A11.118.188', 'A15.145.229.188'], ['D12.776.124.125.300', 'D12.776.811.272', 'D23.119.300'], ['D12.776.124.125.350', 'D12.776.811.286', 'D23.119.350'], ['D12.776.124.270.300', 'D12.776.811.300.290'], ['D12.776.124.050.250', 'D12.776.124.125.500', 'D12.776.811.300', 'D23.119.490'], ['B01... | ['Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Composition of the home care service package: predictors of type, volume, and mix of services provided to poor and frail older people. | This study of 270 poor and frail elders in a Medicaid waiver program examined the service package, that is, the type of service (health or social), volume, and the mix or combinations of services provided. Predictors of use and volume of service differed depending on type of service. The most frequently prescribed serv... | ['Aged', 'Female', 'Frail Elderly', 'Georgia', 'Health Services for the Aged', 'Home Care Services', 'Humans', 'Logistic Models', 'Long-Term Care', 'Male', 'Poverty', 'Program Evaluation'] | 9,127,973 | [['M01.060.116.100'], ['M01.060.116.100.540'], ['Z01.107.567.875.075.250', 'Z01.107.567.875.750.370'], ['N02.421.320'], ['N02.421.143.524', 'N02.421.539.089'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.525', 'E05.318.740.600.800.450', 'E05.318.740.750.450', 'E05.599.835.875', 'N05.715.360.750.5... | ['Named Groups [M]', 'Geographicals [Z]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Attitudes of expectant fathers regarding breast-feeding. | Fathers participate in choosing the feeding method for their newborns. However they traditionally have not been included in most breast-feeding education programs. To examine expectant fathers' attitudes and knowledge regarding breast-feeding, we surveyed 268 men during the first session of their childbirth education c... | ['Attitude', 'Bottle Feeding', 'Breast Feeding', 'Ethnic Groups', 'Fathers', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Immunity, Maternally-Acquired', 'Interpersonal Relations', 'Male', 'Marriage', 'Mother-Child Relations', 'Object Attachment'] | 1,641,286 | [['F01.100'], ['E02.421.150', 'F01.145.407.099', 'G07.203.650.220.500.250', 'G07.203.650.353.099'], ['F01.145.407.199', 'G07.203.650.195', 'G07.203.650.220.500.500', 'G07.203.650.353.199'], ['M01.686.754', 'N01.224.317'], ['F01.829.263.500.320.100', 'I01.880.853.150.500.340.210', 'M01.620.390'], ['F01.100.150.500', 'N0... | ['Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Named Groups [M]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
The West Indian family: treatment challenges. | The authors discuss the culture-specific problems faced by West Indian immigrants who received treatment at the East Brooklyn Prevention Program. The characteristics, patterns, and functioning of this population must be identified before effective treatment can occur. | ['Child', 'Child Abuse', 'Community Mental Health Services', 'Cultural Characteristics', 'Emigration and Immigration', 'Family Characteristics', 'Health Services, Indigenous', 'Humans', 'New York City', 'Research Design', 'Social Work, Psychiatric', 'West Indies'] | 10,286,125 | [['M01.060.406'], ['I01.198.240.856.350.250', 'I01.880.735.900.350.250'], ['F04.408.307', 'N02.421.143.183', 'N02.421.461.232'], ['I01.076.201.450.324', 'I01.880.853.100.329'], ['I01.240.600.525.500', 'N01.224.625.525.500', 'N06.850.505.400.700.525.500'], ['F01.829.263.315', 'I01.240.361', 'I01.880.853.150.423', 'N01.2... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Combinations of the alpha-helix-turn-alpha-helix motif of TetR with respective residues from LacI or 434Cro: DNA recognition, inducer binding, and urea-dependent denaturation. | We constructed 10 different variants of TetR by substituting all or some of the residues in the alpha-helix-turn-alpha-helix (HTH) operator binding motif with the respective amino acids from LacI or 434Cro. The variants were soluble, negative transdominant over tetR in vivo, and as active as wild-type TetR in tetracycl... | ['Amino Acid Sequence', 'Bacterial Proteins', 'Binding Sites', 'DNA-Binding Proteins', 'Escherichia coli Proteins', 'Helix-Turn-Helix Motifs', 'Lac Repressors', 'Models, Molecular', 'Molecular Sequence Data', 'Mutagenesis, Insertional', 'Protein Conformation', 'Protein Denaturation', 'Protein Folding', 'Recombinant Fus... | 9,154,913 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D12.776.097'], ['G02.111.570.120'], ['D12.776.260'], ['D12.776.097.275'], ['G02.111.570.820.709.275.500.360.360'], ['D12.776.097.521', 'D12.776.260.703.600', 'D12.776.930.780.781'], ['E05.599.595'], ['L01.453.245.667'], ['E05.393.420.601.550', 'G05.365.590.575', 'G05.558.5... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Adjuvant transcatheter arterial chemoembolization after curative resection for hepatocellular carcinoma patients with solitary tumor and microvascular invasion: a randomized clinical trial of efficacy and safety. | BACKGROUND: The optimal strategy for adjuvant therapy after curative resection for hepatocellular carcinoma (HCC) patients with solitary tumor and microvascular invasion (MVI) is controversial. This trial evaluated the efficacy and safety of adjuvant transcatheter arterial chemoembolization (TACE) after hepatectomy ver... | ['Adolescent', 'Adult', 'Aged', 'Carcinoma, Hepatocellular', 'Chemoembolization, Therapeutic', 'Female', 'Humans', 'Liver Neoplasms', 'Male', 'Middle Aged', 'Treatment Outcome', 'Young Adult'] | 30,305,149 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['E02.520.360.150', 'E02.926.500.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.274.623', 'C06.301.623', 'C06.552.697'], ['M01.060.116.630'], ['E01.789.800... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Enzyme-linked immunosorbent assay using multimers of the 16th non-collagenous domain of the BP180 antigen for sensitive and specific detection of pemphigoid autoantibodies. | Bullous pemphigoid (BP) and pemphigoid gestationis (PG) are acquired autoimmune subepidermal blistering diseases characterized by autoantibodies against the hemidesmosomal proteins BP180/type XVII collagen and BP230. In the vast majority of BP and PG patients, these autoantibodies bind to epitopes clustered within the ... | ['Autoantibodies', 'Autoantigens', 'Enzyme-Linked Immunosorbent Assay', 'Female', 'Humans', 'Non-Fibrillar Collagens', 'Pemphigoid Gestationis', 'Pemphigoid, Bullous', 'Peptides', 'Pregnancy', 'Protein Structure, Tertiary', 'Recombinant Proteins', 'Sensitivity and Specificity'] | 17,697,150 | [['D12.776.124.486.485.114.323', 'D12.776.124.790.651.114.323', 'D12.776.377.715.548.114.323'], ['D23.050.422'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.860.300.250.400'], ['C13.703.57... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Quantitative analysis of HER2-mediated effects on HER2 and epidermal growth factor receptor endocytosis: distribution of homo- and heterodimers depends on relative HER2 levels. | Endocytic trafficking plays an important role in the regulation of the epidermal growth factor receptor (EGFR) family. Many cell types express multiple EGFR family members (including EGFR, HER2, HER3, and/or HER4) that interact to form an array of homo- and heterodimers. Differential trafficking of these receptors shou... | ['Cell Line', 'Dimerization', 'Endocytosis', 'Epithelial Cells', 'ErbB Receptors', 'Humans', 'Models, Biological', 'Protein Binding', 'Protein Transport', 'Receptor, ErbB-2', 'Signal Transduction'] | 12,686,539 | [['A11.251.210'], ['G02.206', 'G03.230'], ['G04.417'], ['A11.436'], ['D08.811.913.696.620.682.725.400.009', 'D12.776.543.750.630.009', 'D12.776.543.750.750.400.074'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.395'], ['G02.111.679', 'G03.808'], ['G03.143.700'], ['D08.811.913.696.620.682.725.400.009.400'... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Juvenile Nasopharyngeal Angiofibroma Outcomes and Cost: Analysis of the Kids' Inpatient Database. | OBJECTIVE: To report trends in Juvenile Nasopharyngeal Angiofibroma (JNA) hospitalizations and identify key factors affecting treatment outcomes and cost of care in JNA patients.METHODS: The Healthcare Cost and Utilization Project (HCUP) Kids' Inpatient Database was queried for all cases of JNA between the years of 199... | ['Adolescent', 'Angiofibroma', 'Cost of Illness', 'Costs and Cost Analysis', 'Databases, Factual', 'Disease Management', 'Female', 'Follow-Up Studies', 'Hospitalization', 'Humans', 'Incidence', 'Inpatients', 'Male', 'Nasopharyngeal Neoplasms', 'Retrospective Studies', 'Treatment Outcome', 'United States'] | 31,876,164 | [['M01.060.057'], ['C04.557.645.100'], ['N03.219.151.165', 'N05.715.360.300.800.438.375.182', 'N06.850.520.308.980.438.475.046'], ['N03.219.151'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['N04.590.607'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['E02.760.400... | ['Named Groups [M]', 'Diseases [C]', 'Health Care [N]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
Bile acids affect liver mitochondrial bioenergetics: possible relevance for cholestasis therapy. | It has been pointed out that intracellular accumulation of bile acids cause hepatocyte injury in cholestatic disease process. This study was aimed to test if cytotoxicity of these compounds is mediated through mitochondria dysfunction. Bile acids effects on isolated rat liver mitochondrial were analyzed by monitoring c... | ['Adenosine Diphosphate', 'Animals', 'Bile Acids and Salts', 'Cell Membrane Permeability', 'Cholestasis', 'Energy Metabolism', 'Glycine', 'Hydrogen', 'In Vitro Techniques', 'Male', 'Membrane Potentials', 'Mitochondria, Liver', 'Oxygen Consumption', 'Rats', 'Rats, Wistar', 'Taurine'] | 10,966,524 | [['D03.633.100.759.646.138.124', 'D13.695.667.138.124', 'D13.695.827.068.124'], ['B01.050'], ['D04.210.500.105'], ['G03.143.335', 'G04.175'], ['C06.130.120.135'], ['G03.295'], ['D12.125.481'], ['D01.268.406', 'D01.362.340'], ['E05.481'], ['G01.154.535', 'G04.580', 'G07.265.675', 'G11.561.570'], ['A11.284.430.214.190.87... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Acute systemic insulin intolerance does not alter the response of the Akt/GSK-3 pathway to environmental hypoxia in human skeletal muscle. | PURPOSE: To investigate how acute environmental hypoxia regulates blood glucose and downstream intramuscular insulin signaling after a meal in healthy humans.METHODS: Fifteen subjects were exposed for 4 h to normoxia (NOR) or to normobaric hypoxia (HYP, FiO2 = 0.11) in a randomized order 40 min after consumption of a h... | ['Blood Glucose', 'Dietary Carbohydrates', 'Dietary Fats', 'Glucose Transporter Type 4', 'Glycogen Synthase Kinase 3', 'Humans', 'Hypoxia', 'Insulin', 'Insulin Resistance', 'Male', 'Muscle, Skeletal', 'Oxygen', 'Proto-Oncogene Proteins c-akt', 'Signal Transduction', 'Young Adult'] | 25,577,409 | [['D09.947.875.359.448.500'], ['D09.301', 'G07.203.300.362', 'J02.500.362'], ['D10.212.302', 'G07.203.300.375', 'J02.500.375'], ['D12.776.157.530.500.500.937', 'D12.776.157.530.937.563.937', 'D12.776.543.585.500.500.937', 'D12.776.543.585.937.625.937'], ['D05.500.117.875', 'D08.811.913.696.620.682.700.429.500', 'D08.81... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Named Groups [M]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 |
Simultaneous detection of 33 Streptococcus suis serotypes using the luminex xTAG® assay™. | We report the development and evaluation of a serotype-specific xTAG luminex assay (SSA) that allows detection of the 33 serotypes of Streptococcus suis (S. suis). This assay is based on wzy gene targets directly involved in the cps biosynthesis and can be completed 40 min post-PCR amplification. The assay correctly an... | ['Animals', 'Limit of Detection', 'Molecular Typing', 'Multiplex Polymerase Chain Reaction', 'Serotyping', 'Streptococcal Infections', 'Streptococcus suis', 'Swine'] | 26,210,040 | [['B01.050'], ['E05.318.740.872.374', 'N05.715.360.750.725.500', 'N06.850.520.830.872.500'], ['E01.370.225.875.150.125.457', 'E05.200.875.150.125.457', 'E05.393.542'], ['E05.393.620.500.487'], ['E01.370.225.812.742', 'E01.370.225.875.150.125.890', 'E05.200.812.742', 'E05.200.875.150.125.890', 'E05.478.594.780'], ['C01.... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
The first 30 years of the SUS: an uncomfortable balance? | This article takes stock of the implementation of Brazil's public health system in the period since the promulgation of the 1988 Constitution, which enshrines the right to health. It analyzes issues affecting the organizational effectiveness of health service provision such as funding and relations between different sp... | ['Brazil', 'Delivery of Health Care', 'Government Programs', 'Health Policy', 'Humans', 'National Health Programs', 'Patient Rights', 'Public Health'] | 29,972,511 | [['Z01.107.757.176'], ['N04.590.374', 'N05.300'], ['I01.451'], ['I01.655.500.608.400', 'I01.880.604.825.608.400', 'N03.623.500.608.428'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.349.550'], ['I01.880.604.473.650', 'N03.706.437.650'], ['H02.403.720', 'N01.400.550', 'N06.850']] | ['Geographicals [Z]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 |
Growth hormone and sex steroid administration in healthy aged women and men: a randomized controlled trial. | CONTEXT: Hormone administration to elderly individuals can increase lean body mass (LBM) and decrease fat, but interactive effects of growth hormone (GH) and sex steroids and their influence on strength and endurance are unknown.OBJECTIVE: To evaluate the effects of recombinant human GH and/or sex steroids on body comp... | ['Aged', 'Aged, 80 and over', 'Blood Glucose', 'Body Composition', 'Diabetes Mellitus', 'Double-Blind Method', 'Estradiol', 'Female', 'Hematocrit', 'Hormone Replacement Therapy', 'Human Growth Hormone', 'Humans', 'Insulin-Like Growth Factor I', 'Male', 'Medroxyprogesterone Acetate', 'Muscle, Skeletal', 'Oxygen Consumpt... | 12,425,705 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['D09.947.875.359.448.500'], ['G02.111.130', 'G03.180', 'G07.100.049'], ['C18.452.394.750', 'C19.246'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['D04.210.500.365.415.248', 'D06.472.334.851.437.500'], ['E01.370.225.625.400', 'E0... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
DNA looping between the origin of replication of Epstein-Barr virus and its enhancer site: stabilization of an origin complex with Epstein-Barr nuclear antigen 1. | Epstein-Barr nuclear antigen 1 (EBNA-1) is the only viral protein required to support replication of Epstein-Barr virus during the latent phase of its life cycle. The DNA segment required for latent replication, oriP, contains two essential binding regions for EBNA-1, termed FR and DS, that are separated by 1 kilobase ... | ['Animals', 'Antigens, Viral', 'Base Sequence', 'Binding, Competitive', 'Cell Line', 'Cell Nucleus', 'DNA Replication', 'DNA, Viral', 'Enhancer Elements, Genetic', 'Epstein-Barr Virus Nuclear Antigens', 'Herpesvirus 4, Human', 'Microscopy, Electron', 'Molecular Sequence Data', 'Nucleic Acid Conformation', 'Protein Bind... | 1,660,153 | [['B01.050'], ['D23.050.327'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.196.080', 'G02.111.084', 'G02.111.570.120.309'], ['A11.251.210'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['G02.111.225', 'G05.226'], ['D13.444.308.568'], ['G02.111.570.080.689.330', 'G05.360.080.689.330', 'G05.3... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Cortical and subcortical JC virus infection: two unusual cases of AIDS associated progressive multifocal leukoencephalopathy. | Two patients with AIDS and progressive neurological syndromes had necropsies that identified JC virus infection of the cerebral or cerebellar cortex. The unusual presentation of progressive multifocal leukoencephalopathy with grey matter involvement and normal cerebral imaging is discussed. | ['AIDS-Related Opportunistic Infections', 'Adult', 'Biopsy', 'Brain Diseases', 'Cerebellar Cortex', 'Cerebral Cortex', 'Fatal Outcome', 'HIV-1', 'Humans', 'JC Virus', 'Leukoencephalopathy, Progressive Multifocal', 'Male', 'Papillomavirus Infections', 'Tumor Virus Infections'] | 8,057,128 | [['C01.221.250.875.100', 'C01.597.050', 'C01.610.684.050', 'C01.925.597.050', 'C01.925.782.815.616.400.100', 'C20.673.480.100'], ['M01.060.116'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['C10.228.140'], ['A08.186.211.... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Dissolution of rabbit zona by sperm acrosomal extract: effect of calcium (1). | The acrosomal extracts from rabbit spermatozoa were more effective in dissolving the zona pellucida of the rabbit ova in the absence than in the presence of Ca2+. The extracts had high proteolytic activity but low esterolytic activity at alkaline pH in which pH effective zona hydrolysis occurred. The results suggest th... | ['Acrosin', 'Acrosome', 'Animals', 'Calcium', 'Endopeptidases', 'Female', 'Hydrogen-Ion Concentration', 'In Vitro Techniques', 'Male', 'Ovum', 'Rabbits', 'Spermatozoa', 'Zona Pellucida'] | 38,295 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of attention state on electrodermal activity during auditory stimulation of children. | During passive and active listening tasks electrodermal activity of 49 healthy school children was studied. The procedure included baseline recording, a passive listening task, instructions, and simple and discriminative active-listening tasks. On the passive task from Trials 1 to 10, habituation of the amplitude of th... | ['Arousal', 'Attention', 'Auditory Perception', 'Child', 'Child Development', 'Female', 'Galvanic Skin Response', 'Habituation, Psychophysiologic', 'Humans', 'Male', 'Psychomotor Performance'] | 1,528,690 | [['F02.830.104', 'G11.561.035'], ['F02.830.104.214'], ['F02.463.593.071', 'G07.888.125'], ['M01.060.406'], ['F01.525.200', 'G07.345.374.750'], ['E05.796.332', 'F02.830.702.315', 'F04.669.332', 'G07.265.563', 'G13.750.415'], ['F02.463.425.393', 'F02.830.422', 'G11.561.312'], ['B01.050.150.900.649.313.988.400.112.400.400... | ['Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
S-aroylthiooximes: a facile route to hydrogen sulfide releasing compounds with structure-dependent release kinetics. | We report the facile preparation of a family of S-aroylthiooxime (SATO) H2S donors, which are synthesized via a click reaction analogous to oxime formation between S-aroylthiohydroxylamines (SATHAs) and aldehydes or ketones. Analysis of cysteine-triggered H2S release revealed structure-dependent release kinetics with h... | ['Cysteine', 'Half-Life', 'Hydrogen Sulfide', 'Kinetics', 'Molecular Structure', 'Oximes', 'Sulfur Compounds'] | 24,575,729 | [['D02.886.030.230', 'D02.886.489.155', 'D12.125.154.299', 'D12.125.166.230'], ['G01.910.405'], ['D01.029.260.340', 'D01.362.350', 'D01.875.350'], ['G01.374.661', 'G02.111.490'], ['G02.111.570', 'G02.466'], ['D02.092.570.665'], ['D01.875', 'D02.886']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Improved efficiency in acute myocardial infarction care through commitment to emergency department-initiated primary PCI. | STUDY OBJECTIVE: Demonstrate improved efficiency of initial and subsequent in-hospital care following emergency department (ED) physician-initiated primary angioplasty (1 PCI).METHODS: An observational study was undertaken in ST-elevation myocardial infarction patients presenting to a community hospital emergency depar... | ['Adult', 'Aged', 'Aged, 80 and over', 'Angioplasty, Balloon, Coronary', 'Cohort Studies', 'Coronary Circulation', 'Emergency Medical Services', 'Female', 'Follow-Up Studies', 'Humans', 'Length of Stay', 'Male', 'Middle Aged', 'Myocardial Infarction', 'Treatment Outcome'] | 14,660,820 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E02.148.050.060.100', 'E04.100.376.719.100', 'E04.100.814.529.124.060.100', 'E04.100.814.529.968.050', 'E04.502.382.124.060.100', 'E04.502.382.968.050', 'E04.928.220.520.100', 'E05.157.016.060.100'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N0... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
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