Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Enzymatic cell wall degradation of high-pressure-homogenized tomato puree and its effect on lycopene bioaccessibility. | BACKGROUND: High-pressure homogenization disrupts cell structures, assisting carotenoid release from the matrix and subsequent micellarization. However, lycopene bioaccessibility of tomato puree upon high-pressure homogenization is limited by the formation of a process-induced barrier. In this context, cell wall-degrad... | ['Biological Availability', 'Carotenoids', 'Cell Wall', 'Digestion', 'Enzymes', 'Food Handling', 'Fruit', 'Humans', 'Hydrolysis', 'In Vitro Techniques', 'Lycopene', 'Lycopersicon esculentum', 'Pressure'] | 25,640,738 | [['G03.787.151', 'G07.690.725.129'], ['D02.455.326.271.665.202', 'D02.455.426.392.368.367.379.249', 'D02.455.849.131', 'D23.767.261'], ['A11.284.183'], ['G07.203.650.250', 'G10.261.190'], ['D08.811'], ['J01.576.423.200'], ['A18.024.500', 'G07.203.300.562', 'J02.500.562'], ['B01.050.150.900.649.313.988.400.112.400.400']... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Angiotensin-converting enzyme genotype and outcome in pediatric IgA nephropathy. | Angiotensin-converting enzyme (ACE) I/D polymorphism has been implicated as a genetic marker for progression of glomerular disease. Studies of ACE genotypes in adults with IgA nephropathy (IgAN) have yielded conflicting results. We performed ACE genotyping on 79 patients with IgAN diagnosed prior to age 18 years who ha... | ['Adolescent', 'Child', 'Child, Preschool', 'Disease Progression', 'Female', 'Genetic Markers', 'Genotype', 'Glomerulonephritis, IGA', 'Humans', 'Kidney Failure, Chronic', 'Male', 'Peptidyl-Dipeptidase A', 'Proportional Hazards Models', 'Proteinuria', 'Survival Analysis'] | 12,172,761 | [['M01.060.057'], ['M01.060.406'], ['M01.060.406.448'], ['C23.550.291.656'], ['D23.101.387', 'G05.695.450'], ['G05.380'], ['C12.777.419.570.363.608', 'C13.351.968.419.570.363.608', 'C20.111.525'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.777.419.780.750.500', 'C13.351.968.419.780.750.500'], ['D08.811.277.... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Comparison of different methods for detecting human immune deficiency virus in human immunodeficiency virus-seropositive hemophiliacs. | Since the detection of antibodies against the human immune deficiency virus (HIV) does not definitely prove HIV infection in hemophiliacs, virus detection was attempted by virus isolation from the peripheral blood monocytes (PBL), by demonstration of p24 antigen and decline of p24 antibody, and by detection of viral DN... | ['Antibodies, Viral', 'Antigens, Viral', 'Cytopathogenic Effect, Viral', 'DNA, Viral', 'Fluorescent Antibody Technique', 'HIV', 'HIV Seropositivity', 'Hemophilia A', 'Humans', 'Polymerase Chain Reaction', 'T-Lymphocytes'] | 2,689,596 | [['D12.776.124.486.485.114.254', 'D12.776.124.790.651.114.254', 'D12.776.377.715.548.114.254'], ['D23.050.327'], ['E01.370.225.500.384.235', 'E05.200.500.384.235', 'E05.242.384.235', 'G06.920.190'], ['D13.444.308.568'], ['E01.370.225.500.607.512.240', 'E01.370.225.750.551.512.240', 'E05.200.500.607.512.240', 'E05.200.7... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A factor contained in plasma is required for IGF binding protein-1 to potentiate the effect of IGF-I on smooth muscle cell DNA synthesis. | One of the forms of the insulin-like growth factor (IGF) binding proteins present in human amniotic fluid has been shown to potentiate the growth-promoting effect of IGF-I markedly. This study was undertaken to determine the cellular and hormonal factors that modulate this potentiation and to determine whether this pro... | ['Animals', 'Biological Factors', 'Carrier Proteins', 'DNA', 'Epidermal Growth Factor', 'Fibroblast Growth Factors', 'G1 Phase', 'Insulin-Like Growth Factor Binding Proteins', 'Insulin-Like Growth Factor I', 'Insulin-Like Growth Factor II', 'Muscle, Smooth', 'Platelet-Derived Growth Factor', 'Swine', 'Thymidine', 'Trit... | 1,698,793 | [['B01.050'], ['D23'], ['D12.776.157'], ['D13.444.308'], ['D06.472.317.350', 'D12.644.276.382.500', 'D12.776.467.382.500', 'D23.529.382.500'], ['D12.644.276.624', 'D12.776.467.624', 'D23.529.624'], ['G04.144.500.320'], ['D12.776.157.420'], ['D12.644.276.937.400', 'D12.776.124.862.400', 'D12.776.467.937.400', 'D23.529.9... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Amended safety assessment of Hypericum perforatum-derived ingredients as used in cosmetics. | The Cosmetic Ingredient Review Expert Panel (Panel) has issued an amended safety assessment of 7 Hypericum perforatum-derived ingredients as used in cosmetics. A common name for this plant is St John wort. These ingredients function in cosmetics as skin-conditioning agents-miscellaneous and antimicrobial agents. The Pa... | ['Animals', 'Biological Products', 'Consumer Product Safety', 'Cosmetics', 'DNA Damage', 'Humans', 'Hypericum', 'Plant Extracts', 'Randomized Controlled Trials as Topic', 'Reproduction', 'Toxicity Tests'] | 25,297,909 | [['B01.050'], ['D20.215'], ['N06.850.210'], ['D27.720.269', 'J01.516.213'], ['G05.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.650.940.800.575.912.250.859.625.500'], ['D20.215.784.500', 'D26.667'], ['E05.318.372.250.250.365.500', 'N05.715.360.330.250.250.365.500', 'N06.850.520.450.250.250.365.500'], ['... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Melghirimyces algeriensis gen. nov., sp. nov., a member of the family Thermoactinomycetaceae, isolated from a salt lake. | A novel filamentous bacterium, designated NariEX(T), was isolated from soil collected from Chott Melghir salt lake, which is located in the south-east of Algeria. The strain was an aerobic, halotolerant, thermotolerant, Gram-positive bacterium that was able to grow in NaCl concentrations up to 21% (w/v), at 37-60 °C an... | ['Aerobiosis', 'Algeria', 'Bacillales', 'Bacterial Typing Techniques', 'Base Composition', 'Cluster Analysis', 'DNA, Bacterial', 'DNA, Ribosomal', 'Environmental Microbiology', 'Fatty Acids', 'Hydrogen-Ion Concentration', 'Molecular Sequence Data', 'Phospholipids', 'Phylogeny', 'RNA, Ribosomal, 16S', 'Sequence Analysis... | 21,856,989 | [['G02.111.017', 'G03.049'], ['Z01.058.266.104'], ['B03.353.500', 'B03.510.100'], ['E01.370.225.875.150.125', 'E05.200.875.150.125'], ['G02.111.080'], ['E05.318.740.250', 'N05.715.360.750.200', 'N06.850.520.830.250'], ['D13.444.308.212'], ['D13.444.308.475'], ['H01.158.273.540.274', 'N06.850.425'], ['D10.251'], ['G02.3... | ['Phenomena and Processes [G]', 'Geographicals [Z]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Information Science [L]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 |
Extensive cortical involvement in leptomeningeal carcinomatosis. | We present a 77-year-old previously well patient with facial asymmetry and progressive weakness of the lower extremities. An initial MRI revealed slight contrast enhancement of the meninges. Three consecutive cerebrospinal fluid examinations demonstrated low glucose concentration, marked elevation of total protein and ... | ['Adenocarcinoma', 'Aged', 'Brain', 'Diagnosis, Differential', 'Fatal Outcome', 'Humans', 'Lung Neoplasms', 'Meningeal Carcinomatosis', 'Tuberculosis, Meningeal'] | 22,989,786 | [['C04.557.470.200.025'], ['M01.060.116.100'], ['A08.186.211'], ['E01.171'], ['E05.318.308.985.550.325', 'N01.224.935.698.201', 'N06.850.505.400.975.550.325', 'N06.850.520.308.985.550.325'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['C04.588.614.250.580.150... | ['Diseases [C]', 'Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Gallic acid decreases vacuous chewing movements induced by reserpine in rats. | Involuntary oral movements are present in several diseases and pharmacological conditions; however, their etiology and efficient treatments remain unclear. Gallic acid is a natural polyphenolic acid found in gall nuts, sumac, oak bark, tea leaves, grapes and wine, with potent antioxidant and antiapoptotic activity. Thu... | ['Adrenergic Uptake Inhibitors', 'Animals', 'Antioxidants', 'Antipsychotic Agents', 'Brain', 'Disease Models, Animal', 'Dyskinesia, Drug-Induced', 'Gallic Acid', 'Male', 'Mastication', 'Oxidative Stress', 'Rats', 'Rats, Wistar', 'Reserpine', 'Sodium-Potassium-Exchanging ATPase'] | 23,313,549 | [['D27.505.519.562.437.050', 'D27.505.519.625.050.601', 'D27.505.519.625.600.050', 'D27.505.696.577.050.601', 'D27.505.696.577.600.050'], ['B01.050'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['D27.505.696.277.950.040', 'D27.505.954.427.210.950.040', 'D27.505.954.427.700.872.331'], ['A08.186.211']... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Immunological status of patients with atherosclerotic lesions of the vessels of the lower limbs]. | In 116 patients with atherosclerosis of the arteries of the lower extremities in stages I-IV of the impairment in circulation and 35 healthy subjects, the immune status was studied. With aggravation of the disease, the number of leukocytes, B-cells, concentration of the IgM, IgG and circulating immune complexes, the nu... | ['Aged', 'Aged, 80 and over', 'Antigen-Antibody Complex', 'Arteriosclerosis', 'Complement System Proteins', 'Female', 'Humans', 'Immunoglobulins', 'Leg', 'Leukocyte Count', 'Male', 'Middle Aged', 'Phagocytosis'] | 2,796,131 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['D12.776.124.486.485.114.257', 'D12.776.124.790.651.114.257', 'D12.776.377.715.548.114.257', 'D23.050.101'], ['C14.907.137.126'], ['D12.776.124.486.274'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.124.486.485', 'D12.776.124.790.651', 'D12.776.377.715.548'... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Clinical spectrum and survival analysis of 145 cases of HIV-negative Castleman's disease: renal function is an important prognostic factor. | Castleman's disease (CD) is a rare lymphoproliferative disorder with clinical features and prognostic factors that are incompletely characterized. This retrospective single-center study reviewed the largest HIV-negative CD patient cohort (n = 145) to date. By clinical classification, we identified 69 patients (47.6%) a... | ['Adolescent', 'Adult', 'Aged', 'Castleman Disease', 'Child', 'Female', 'Follow-Up Studies', 'Glomerular Filtration Rate', 'HIV', 'Humans', 'Kidney', 'Male', 'Middle Aged', 'Prognosis', 'Retrospective Studies', 'Risk Factors', 'Survival Analysis'] | 27,029,894 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['C15.604.515.245', 'C20.683.515.250'], ['M01.060.406'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['E01.370.390.400.300', 'G08.852.357'], ['B04.820.650.589.650.350'], ['B01.050.150.900.649.313.988.400.112.400.400']... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Ionothermal synthesis of hierarchical BiOBr microspheres for water treatment. | Bismuth oxybromide (BiOBr) micropsheres with hierarchical morphologies have been fabricated via an ionothermal synthesis route. Ionic liquid acts as a unique soft material capable of promoting nucleation and in situ growth of 3D hierarchical BiOBr mesocrystals without the help of surfactants. The as-prepared BiOBr nano... | ['Adsorption', 'Bacterial Load', 'Bismuth', 'Catalysis', 'Chromium', 'Disinfection', 'Imidazoles', 'Ionic Liquids', 'Light', 'Methylene Blue', 'Micrococcus', 'Microspheres', 'Photolysis', 'Waste Disposal, Fluid', 'Water Pollutants, Chemical', 'Water Purification'] | 22,088,503 | [['G01.030', 'G02.020'], ['E01.370.225.875.150.115', 'E01.370.225.875.220.115', 'E05.200.875.150.115', 'E05.200.875.220.115', 'G06.099.100'], ['D01.268.271.245', 'D01.268.556.100', 'D01.496.749.305.245', 'D01.552.544.100'], ['G02.130'], ['D01.268.556.175', 'D01.268.956.124', 'D01.552.544.175'], ['N06.850.780.200.450.85... | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Impact of alternative medical device approval processes on costs and health. | BACKGROUND: Medical devices are often introduced prior to randomized-trial evidence of efficacy and this slows completion of trials. Alternative regulatory approaches include restricting device use outside of trials prior to trial evidence of efficacy (like the drug approval process) or restricting out-of-trial use but... | ['Costs and Cost Analysis', 'Device Approval', 'Equipment and Supplies', 'Health', 'Humans', 'Insurance', 'Insurance Coverage', 'Models, Economic', 'Product Surveillance, Postmarketing'] | 25,185,975 | [['N03.219.151'], ['E05.337.275', 'N06.850.210.275'], ['E07'], ['N01.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.219.521.576'], ['N03.219.521.576.265'], ['E05.318.740.500.600', 'E05.599.835.890', 'N05.715.360.750.530.500', 'N06.850.520.830.500.600'], ['E05.337.800']] | ['Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[Expression of protooncogene c-jun, p38 and proliferating cell nuclear antigen in intestinal epithelial cells in rats different development stages]. | OBJECTIVE: To investigate the expression characteristics of protooncogene c-jun and its related gene p38 in different developmental intestinal epithelial cells in rats, and to explore their biological roles in the intestinal wound healing after injury.METHODS: Immunohistochemical techniques were used to detect the expr... | ['Animals', 'Cell Differentiation', 'Cell Proliferation', 'Epithelial Cells', 'Female', 'Genes, jun', 'Intestinal Mucosa', 'Intestine, Small', 'Male', 'Proliferating Cell Nuclear Antigen', 'Rats', 'Rats, Wistar', 'p38 Mitogen-Activated Protein Kinases'] | 12,857,463 | [['B01.050'], ['G04.152'], ['G04.161.750', 'G07.345.249.410.750'], ['A11.436'], ['G05.360.340.024.340.375.500.791.365'], ['A03.556.124.369', 'A10.615.550.444'], ['A03.556.124.684'], ['D12.776.660.740', 'D23.050.290.750', 'D23.101.140.600'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Circulating advanced glycation end products (AGEs) and soluble form of receptor for AGEs (sRAGE) are independent determinants of serum monocyte chemoattractant protein-1 (MCP-1) levels in patients with type 2 diabetes. | BACKGROUND: Atherosclerosis is an inflammatory disease. Monocyte chemoattractant protein-1 (MCP-1) is an essential chemokine responsible for the recruitment of monocytes to inflammatory lesions in the vasculature, an initial step of atherosclerosis. Since serum levels of MCP-1 are higher in patients with type 2 diabete... | ['Aged', 'Chemokine CCL2', 'Diabetes Mellitus, Type 2', 'Female', 'Glycation End Products, Advanced', 'Humans', 'Male', 'Middle Aged', 'Receptor for Advanced Glycation End Products', 'Receptors, Immunologic', 'Regression Analysis', 'Solubility'] | 17,694,504 | [['M01.060.116.100'], ['D12.644.276.374.200.110.990.600', 'D12.776.467.374.200.110.990.600', 'D23.125.300.110.990.600', 'D23.469.200.110.990.600', 'D23.529.374.200.110.990.500'], ['C18.452.394.750.149', 'C19.246.300'], ['D12.776.643.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['D12.776.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[An application of dynamic CT for diagnosis of abnormal external ocular muscle movement]. | To evaluate the movements of retrobulbar structures radiologically, we have developed a new technique called "external ocular muscle movement CT" (EOM CT), in which dynamic CT scanning is performed while the patient performs controlled eye movements. This new technique was applied in one volunteer and 72 patients with ... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Eye Movements', 'Female', 'Humans', 'Male', 'Middle Aged', 'Oculomotor Muscles', 'Ophthalmoplegia', 'Orbital Fractures', 'Tomography, X-Ray Computed'] | 8,255,746 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['G11.427.410.140', 'G14.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['A02.633.567.700'], ['C10.292.562.750', 'C10.597.622.447', 'C11.590.472', 'C23.888.592.636.447'], ['C10.900.300.284.500.550', 'C26.404.7... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Sociological, legal and theological aspects of selection for treatment in myelomeningocele (author's transl)]. | The arbitrary and arrogant presumption to be entitled to select cases for treatment amongst severely handicapped children cannot be justified at all, either from the legal or the theological point of view. The idea of selection can only be explained on the basis of the discrepancy in modern medicine between being force... | ['Austria', 'Congenital Abnormalities', 'Decision Making', 'Ethics, Medical', 'Female', 'Human Rights', 'Humans', 'Infant, Newborn', 'Legislation, Medical', 'Morals', 'Physician-Patient Relations', 'Pregnancy', 'Prenatal Diagnosis', 'Religion and Medicine', 'Spinal Dysraphism'] | 327,703 | [['Z01.542.088'], ['C16.131'], ['F02.463.785.373'], ['K01.752.566.479.171.132.750', 'N05.350.340.162.500'], ['I01.880.604.473', 'N03.706.437'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['N03.706.615.473'], ['F01.829.500', 'K01.752.566'], ['F01.829.401.650.675', 'N05.300.660.625'], ['G08.686... | ['Geographicals [Z]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Humanities [K]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Clinical impact of intravascular ultrasound guidance in drug-eluting stent implantation for unprotected left main coronary disease: pooled analysis at the patient-level of 4 registries. | OBJECTIVES: This study sought to investigate the clinical impact of the use of intravascular ultrasound (IVUS) during revascularization of patients with left main coronary artery (LM) disease with drug-eluting stents (DES).BACKGROUND: Whether the use of IVUS during the procedure adds a clinical benefit remains unclear.... | ['Aged', 'Blood Vessel Prosthesis Implantation', 'Coronary Artery Disease', 'Drug-Eluting Stents', 'Female', 'Humans', 'Male', 'Myocardial Revascularization', 'Postoperative Complications', 'Propensity Score', 'Registries', 'Spain', 'Surgery, Computer-Assisted', 'Survival Rate', 'Ultrasonography, Interventional'] | 24,650,399 | [['M01.060.116.100'], ['E04.100.814.868.500', 'E04.650.200'], ['C14.280.647.250.260', 'C14.907.137.126.339', 'C14.907.585.250.260'], ['E07.695.750.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.100.376.719', 'E04.928.220.520'], ['C23.550.767'], ['E05.318.740.600.675', 'N05.715.360.750.625.620', 'N06.850.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Coronary artery bypass grafting using two different anesthetic techniques: Part 2: Postoperative outcome. | The aim of the present investigation was to study the effects of intraoperative and postoperative epidural pain management during and after coronary artery bypass grafting (CABG) on the recovery time, postoperative pulmonary and cardiac parameters, visual analog scale (VAS) scores, and sedation scores (SS) compared wit... | ['Analgesia, Epidural', 'Anesthesia, Intravenous', 'Bupivacaine', 'Coronary Artery Bypass', 'Fentanyl', 'Humans', 'Injections, Intravenous', 'Midazolam', 'Morphine Derivatives', 'Nicotinic Acids', 'Pain, Postoperative', 'Preanesthetic Medication', 'Sufentanil', 'Treatment Outcome'] | 1,533,166 | [['E03.091.080'], ['E03.155.308'], ['D02.065.199.239', 'D02.092.146.113.239'], ['E04.100.376.719.332', 'E04.100.814.868.750', 'E04.928.220.520.220'], ['D03.383.621.265'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.267.082.750', 'E02.319.267.530.540'], ['D03.633.100.079.080.575'], ['D03.132.577.249.562',... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[Role of inducible nitric oxide synthase in acute gastric mucosal damage in stress, in rats]. | In groups of female Wistar rats, someted to stress by immobilization and immersion in 18 degrees C water during 6 hrs, the role of nitric oxide (NO) in its pathophysiologic was studied. Agonist and antagonist of the isoforms Constitutive NO Synthase (cNOS) and of the inducible NO Synthase (iNOS) were used. Was found th... | ['Acute Disease', 'Animals', 'Dexamethasone', 'Excitatory Amino Acid Agonists', 'Female', 'Gastric Mucosa', 'Guanidines', 'N-Methylaspartate', 'Nitric Oxide', 'Nitric Oxide Synthase', 'Nitric Oxide Synthase Type II', 'Rats', 'Rats, Wistar', 'Statistics, Nonparametric', 'Stress, Physiological'] | 9,335,925 | [['C23.550.291.125'], ['B01.050'], ['D04.210.500.745.432.769.344', 'D04.210.500.908.238'], ['D27.505.519.625.190.200', 'D27.505.696.577.190.200'], ['A03.556.875.875.440', 'A10.615.550.291'], ['D02.078.370'], ['D12.125.067.500.400', 'D12.125.119.170.400'], ['D01.339.387', 'D01.625.550.500', 'D01.625.700.500', 'D01.650.5... | ['Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Effect of diet on folates levels and distribution in selected tissues of the rat. | A technique for the extraction, purification and concentration of folates, followed by high performance liquid chromatography assay with fluorometric detection of the three principal derivatives (tetrahydrofolic, 5-methyl-tetrahydrofolic and formyl-tetrahydrofolic acids) has been applied to the determination of tissue ... | ['Animals', 'Brain', 'Chromatography, High Pressure Liquid', 'Diet', 'Fluorometry', 'Folic Acid', 'Intestinal Mucosa', 'Liver', 'Male', 'Rats', 'Tissue Distribution'] | 1,380,335 | [['B01.050'], ['A08.186.211'], ['E05.196.181.400.300'], ['G07.203.650.240'], ['E05.196.712.516.600'], ['D03.633.100.733.631.400'], ['A03.556.124.369', 'A10.615.550.444'], ['A03.620'], ['B01.050.150.900.649.313.992.635.505.700'], ['G03.787.917', 'G07.690.725.949']] | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The epistemically virtuous clinician. | Today, modern Western medicine is facing a quality-of-care crisis that is undermining the patient-physician relationship. In this paper, a notion of the epistemically virtuous clinician is proposed in terms of both the reliabilist and responsibilist versions of virtue epistemology, in order to help address this crisis.... | ['Abdominal Pain', 'Chronic Disease', 'Ethics, Clinical', 'Ethics, Medical', 'Feeding and Eating Disorders', 'Female', 'Humans', 'Knowledge', 'Moral Obligations', 'Physician-Patient Relations', 'Rape', 'Virtues', 'Young Adult'] | 19,548,115 | [['C23.888.592.612.054', 'C23.888.821.030'], ['C23.550.291.500'], ['K01.752.566.479.045.500', 'K01.752.566.479.171.132', 'N05.350.200.500', 'N05.350.340.162'], ['K01.752.566.479.171.132.750', 'N05.350.340.162.500'], ['F03.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['K01.468'], ['F01.829.500.760.500', 'K01.... | ['Diseases [C]', 'Humanities [K]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Most common diseases diagnosed in primary care in Stockholm, Sweden, in 2011. | BACKGROUND: The most commonly reported diagnoses in primary care are useful to identify and meet health care needs in society. We estimated the rates of the most common diagnoses in primary health care in total and also by gender.METHODS: This was a cross-sectional study including all 2.0 million inhabitants living in ... | ['Adolescent', 'Adult', 'Age Factors', 'Aged', 'Aged, 80 and over', 'Back Pain', 'Child', 'Child, Preschool', 'Cough', 'Cross-Sectional Studies', 'Diabetes Mellitus, Type 2', 'Female', 'Health Services Needs and Demand', 'Humans', 'Hypertension', 'Infant', 'Male', 'Middle Aged', 'Primary Health Care', 'Respiratory Trac... | 23,825,186 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C23.888.592.612.107'], ['M01.060.406'], ['M01.060.406.448'], ['C08.618.248', 'C23.888.852.293'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['C18.452.394.750.149... | ['Named Groups [M]', 'Health Care [N]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Hypolipidemic activity of phthalimide derivatives IV: Further chemical modification and investigation of the hypolipidemic activity of N-substituted imides. | A further investigation of N-substituted derivatives of phthalimide for hypolipidemic activity has revealed that the chain length, as well as the type of substitution on the N-alkyl chain of phthalimide is critical for biological activity. In these studies the hypolipidemic activity was not improved by extending the ch... | ['Animals', 'Chemical Phenomena', 'Chemistry', 'Hypolipidemic Agents', 'Imides', 'Male', 'Mice', 'Structure-Activity Relationship', 'Triglycerides'] | 6,644,601 | [['B01.050'], ['G02'], ['H01.181'], ['D27.505.519.186.071', 'D27.505.954.557.500'], ['D02.478'], ['B01.050.150.900.649.313.992.635.505.500'], ['G02.111.830', 'G07.690.773.997'], ['D10.351.801']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Promotion versus suppression of rat colon carcinogenesis by chlorophyllin and chlorophyll: modulation of apoptosis, cell proliferation, and beta-catenin/Tcf signaling. | The carcinogens 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 1,2-dimethylhydrazine (DMH) induce colon tumors in the rat that contain mutations in beta-catenin, but the mutation pattern can be influenced by exposure to dietary phytochemicals, such as the water-soluble derivative of chlorophyll called chlorophyllin. ... | ['1,2-Dimethylhydrazine', 'Animals', 'Anticarcinogenic Agents', 'Apoptosis', 'Carcinogens', 'Chlorophyll', 'Chlorophyllides', 'Colonic Neoplasms', 'Cytoskeletal Proteins', 'Quinolines', 'Rats', 'Trans-Activators', 'beta Catenin'] | 12,628,520 | [['D02.442.600.400.200'], ['B01.050'], ['D27.505.696.706.018', 'D27.505.954.248.125', 'D27.720.799.018'], ['G04.146.954.035'], ['D27.888.569.100'], ['D03.383.129.578.840.374', 'D03.633.400.909.374', 'D04.345.783.374'], ['D03.383.129.578.840.374.180', 'D03.633.400.909.374.180', 'D04.345.783.374.180'], ['C04.588.274.476.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Process and treatment adherence factors in group cognitive-behavioral therapy for partner violent men. | This study used multilevel modeling to examine process and treatment adherence factors as predictors of collateral partner reports of abuse following participation in a cognitive-behavioral grouptreatment program for partner violent men (N = 107). Therapist working alliance ratings predicted lower levels of physical an... | ['Adult', 'Cognitive Behavioral Therapy', 'Domestic Violence', 'Humans', 'Male', 'Patient Compliance'] | 12,924,686 | [['M01.060.116'], ['F04.754.137.350'], ['I01.198.240.856.350', 'I01.880.735.900.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.100.150.750.500.600', 'F01.145.488.887.500.600', 'N05.300.150.800.500.600']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Analysis of prenatal diagnosis before and after implementation of the two-child policy in northeastern China. | The universal two-child policy has now been fully implemented in China. This change requires adaptations to maternal care and childcare systems, but the features of prenatal diagnosis before and after implementation of the policy have not been reported.We conducted a retrospective study of 6736 prenatal cytogenetic dia... | ['Adult', 'Age Factors', 'Amniocentesis', 'China', 'Chromosome Aberrations', 'Female', 'Humans', 'Population Control', 'Pregnancy', 'Prenatal Diagnosis', 'Public Policy', 'Retrospective Studies', 'Young Adult'] | 31,567,968 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['E01.370.225.500.384.050', 'E01.370.225.998.329.309', 'E01.370.378.630.050', 'E04.665.600.309', 'E05.200.500.384.050', 'E05.200.998.329.309', 'E05.242.384.050'], ['Z01.252.474.164'], ['C23.550.210', 'G05.365.590.175'], ['B01.050.150.900.649.313.988.400.112.400.... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Renal implications of pulmonary arterial capacitance in acute heart failure with preserved ejection fraction. | Worsening renal function in patients with heart failure with preserved ejection fraction is associated with poor outcomes. Pulmonary arterial capacitance is a novel right heart catheterization derived hemodynamic metric representing pulmonary arterial tree distensibility and right ventricle afterload. Given the strong ... | ['Aged', 'Aged, 80 and over', 'Arterial Pressure', 'Cardiac Catheterization', 'Cardio-Renal Syndrome', 'Disease Progression', 'Electronic Health Records', 'Female', 'Glomerular Filtration Rate', 'Heart Failure', 'Humans', 'Kidney', 'Male', 'Middle Aged', 'Prognosis', 'Pulmonary Artery', 'Retrospective Studies', 'Stroke... | 31,912,718 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['G09.330.380.076.347'], ['E01.370.370.380.140', 'E02.148.442', 'E05.157.250'], ['C12.777.419.780.400', 'C13.351.968.419.780.400', 'C14.280.434.156'], ['C23.550.291.656'], ['E05.318.308.940.968.625.500', 'N04.452.859.564.650.125', 'N05.715.360.300.715.500.530.250', 'N06.85... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Long-term management of tracheoesophageal fistula--successful control by esophageal segmentation and stomach pull-up]. | Following amniotic embolism a severe ARDS developed in a 21 year-old women. After two months of respirator therapy a giant tracheoesophageal fistula arose. Successful conservative treatment allowed recovery and weaning from the respirator. Our two step surgical management consisted of esophageal diversion and reconstru... | ['Adult', 'Cesarean Section', 'Esophagus', 'Female', 'Humans', 'Intubation, Intratracheal', 'Postoperative Complications', 'Pregnancy', 'Stomach', 'Suture Techniques', 'Tracheoesophageal Fistula'] | 3,533,459 | [['M01.060.116'], ['E04.520.252.500'], ['A03.556.875.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.041.500', 'E02.585.578', 'E05.497.578'], ['C23.550.767'], ['G08.686.784.769'], ['A03.556.875.875'], ['E04.987.775'], ['C06.267.250.725', 'C06.405.117.367.725', 'C08.702.750', 'C08.907.863', 'C23.300.575.18... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
An official American Thoracic Society Statement: pulmonary hypertension phenotypes. | BACKGROUND: Current classification of pulmonary hypertension (PH) is based on a relatively simple combination of patient characteristics and hemodynamics. This limits customization of treatment, and lacks the clarity of a more granular identification based on individual patient phenotypes. Rapid advances in mechanistic... | ['Age Factors', 'Biomarkers', 'Connective Tissue Diseases', 'Diagnostic Imaging', 'HIV Infections', 'Humans', 'Hypertension, Portal', 'Hypertension, Pulmonary', 'Hypertrophy, Right Ventricular', 'Medical History Taking', 'Metabolic Syndrome', 'Phenotype', 'Physical Examination', 'Severity of Illness Index'] | 24,484,330 | [['N05.715.350.075', 'N06.850.490.250'], ['D23.101'], ['C17.300'], ['E01.370.350'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C06.552.494'], ['C08.381.423', 'C14.907.489.556'], ['C14.280.... | ['Health Care [N]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[The correction of the fluorine load in caries]. | The authors discuss the problem of fluorine load correction in caries. They claim that fluorine load of the body as regards caries prevention should never surpass the safe levels of total daily fluorine consumption. In children aged over 4 the safe level of total daily fluorine consumption is 2.5 mg, in adults 4 mg. | ['Adolescent', 'Adult', 'Child', 'Child, Preschool', 'Dental Caries', 'Fluoridation', 'Fluorides', 'Humans', 'Infant', 'Maximum Allowable Concentration', 'Ukraine'] | 8,048,138 | [['M01.060.057'], ['M01.060.116'], ['M01.060.406'], ['M01.060.406.448'], ['C07.793.720.210'], ['E06.761.382', 'N06.890.235'], ['D01.248.497.158.380', 'D01.303.350.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['N06.850.460.350.210', 'N06.850.460.350.600.615'], ['Z01.542.248.960', 'Z01.542.931... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
A tale of two CRs: hospital conducts side-by-side test. | While we elected to install a digital radiography system in the busiest exam room in emergency room (ER) suite at our 535-bed hospital, we selected computed radiography as the primary platform for digital capture throughout the facility because of its flexibility, productivity and cost-effectiveness. We now use CR syst... | ['Decision Making, Organizational', 'Emergency Service, Hospital', 'Evaluation Studies as Topic', 'Hospital Bed Capacity, 500 and over', 'Interdepartmental Relations', 'Interprofessional Relations', 'Radiographic Image Enhancement', 'Radiographic Image Interpretation, Computer-Assisted', 'Radiology Department, Hospital... | 12,800,561 | [['N04.452.190'], ['N02.278.216.500.968.336', 'N02.421.297.195', 'N04.452.442.452.422.336'], ['E05.337', 'N05.715.360.335'], ['N02.278.306.472.300'], ['N04.452.822.388'], ['F01.829.401.205'], ['E01.370.350.600.350.700', 'E01.370.350.700.700', 'L01.224.308.380.600'], ['E01.158.600.680', 'E01.370.350.350.700', 'E01.370.3... | ['Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Information Science [L]', 'Geographicals [Z]'] | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 |
Na+-K+ pump activation inhibits endothelium-dependent relaxation by activating the forward mode of Na+/Ca2+ exchanger in mouse aorta. | The effect of Na+-K+ pump activation on endothelium-dependent relaxation (EDR) and on intracellular Ca2+ concentration ([Ca2+]i) was examined in mouse aorta and mouse aortic endothelial cells (MAECs). The Na+-K+ pump was activated by increasing extracellular K+ concentration ([K+]o) from 6 to 12 mM. In aortic rings, th... | ['Animals', 'Aorta, Thoracic', 'Cyclic AMP', 'Endothelium, Vascular', 'Female', 'In Vitro Techniques', 'Ionophores', 'Male', 'Mice', 'Monensin', 'Muscle Relaxation', 'Muscle, Smooth, Vascular', 'Nickel', 'Ouabain', 'Potassium', 'RNA', 'Reverse Transcriptase Polymerase Chain Reaction', 'Sodium', 'Sodium-Calcium Exchange... | 15,994,853 | [['B01.050'], ['A07.015.114.056.372'], ['D03.633.100.759.646.138.395', 'D13.695.462.200', 'D13.695.667.138.395', 'D13.695.827.068.395'], ['A07.015.700.500', 'A10.272.491.355'], ['E05.481'], ['D27.505.519.562.374', 'D27.720.395'], ['B01.050.150.900.649.313.992.635.505.500'], ['D03.383.312.600'], ['G11.427.494.554'], ['A... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The Chinese herb polyphyllin D sensitizes ovarian cancer cells to cisplatin-induced growth arrest. | PURPOSE: We evaluated the effects of polyphyllin D (PD), a natural compound with anti-neoplastic activity and a major component of the Chinese herb Paris polyphylla, on ovarian cancer (OVCA) cell line proliferation and platinum sensitivity.METHODS: A panel of 20 OVCA cell lines was subjected to PD treatment, MTS prolif... | ['Antineoplastic Agents', 'Biomarkers, Tumor', 'Cell Proliferation', 'Cisplatin', 'Diosgenin', 'Drug Resistance, Neoplasm', 'Female', 'Gene Expression Profiling', 'Humans', 'Oligonucleotide Array Sequence Analysis', 'Ovarian Neoplasms', 'RNA, Messenger', 'Real-Time Polymerase Chain Reaction', 'Reverse Transcriptase Pol... | 25,164,128 | [['D27.505.954.248'], ['D23.101.140'], ['G04.161.750', 'G07.345.249.410.750'], ['D01.210.375', 'D01.625.125', 'D01.710.100'], ['D04.210.500.247.515.500'], ['G07.690.773.984.395'], ['E05.393.332'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.393.661.640', 'E05.393.760.640', 'E05.588.570.660', 'E05.601.640'], ... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Exposure to extremely low-frequency electromagnetic fields modulates Na+ currents in rat cerebellar granule cells through increase of AA/PGE2 and EP receptor-mediated cAMP/PKA pathway. | Although the modulation of Ca(2+) channel activity by extremely low-frequency electromagnetic fields (ELF-EMF) has been studied previously, few reports have addressed the effects of such fields on the activity of voltage-activated Na(+) channels (Na(v)). Here, we investigated the effects of ELF-EMF on Na(v) activity in... | ['Animals', 'Arachidonic Acid', 'Brain', 'Cerebellum', 'Cyclooxygenase 1', 'Cyclooxygenase 2', 'Cyclooxygenase Inhibitors', 'Dinoprostone', 'Electromagnetic Fields', 'Membrane Proteins', 'Phosphorylation', 'Rats', 'Receptors, Cyclic AMP', 'Receptors, Prostaglandin E', 'Signal Transduction', 'Voltage-Gated Sodium Channe... | 23,349,866 | [['B01.050'], ['D10.251.355.255.100.100', 'D10.251.355.310.166.100'], ['A08.186.211'], ['A08.186.211.132.810.428.200'], ['D08.811.600.720.500'], ['D08.811.600.720.750'], ['D27.505.519.389.310', 'D27.505.696.663.850.014.040.500.500', 'D27.505.954.158.030.500', 'D27.505.954.329.030.500'], ['D10.251.355.255.550.250.200', ... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Publication bias in laboratory animal research: a survey on magnitude, drivers, consequences and potential solutions. | CONTEXT: Publication bias jeopardizes evidence-based medicine, mainly through biased literature syntheses. Publication bias may also affect laboratory animal research, but evidence is scarce.OBJECTIVES: To assess the opinion of laboratory animal researchers on the magnitude, drivers, consequences and potential solution... | ['Animal Experimentation', 'Animals', 'Animals, Laboratory', 'Data Collection', 'Evidence-Based Medicine', 'Netherlands', 'Peer Review', 'Publication Bias', 'Publications', 'Reproducibility of Results', 'Research Design'] | 22,957,028 | [['E05.017', 'H01.770.644.053'], ['B01.050'], ['B01.050.050.199'], ['E05.318.308', 'L01.399.250', 'N05.715.360.300', 'N06.850.520.308'], ['H02.249.750', 'H02.403.200.400'], ['Z01.542.651'], ['F01.829.316.549', 'I01.880.604.640', 'N03.706.700'], ['L01.737.813'], ['L01.178.682'], ['E05.318.370.725', 'E05.337.851', 'N05.7... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Information Science [L]', 'Health Care [N]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 |
[Stearic acid methyl ether: a new extracellular metabolite of the obligate methylotrophic bacterium Methylophilus quaylei]. | Methyl esters of fatty acids, free fatty acids, and hydrocarbons were found in the culture liquid and in the cellular lipids of the obligate methylotrophic bacterium Methylophilus quaylei under optimal growth conditions and osmotic stress. The main extracellular hydrophobic metabolite was methyl stearate. Exogenous fre... | ['Adaptation, Physiological', 'Methylophilus', 'Stearates', 'Stearic Acids'] | 20,391,761 | [['G07.025', 'G16.012.500'], ['B03.440.400.425.525.520', 'B03.660.075.495.520'], ['D10.251.882.800'], ['D10.251.882']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
6-OHDA-Induced Changes in Parkinson's Disease-Related Gene Expression are not Affected by the Overexpression of PGAM5 in In Vitro Differentiated Embryonic Mesencephalic Cells. | LUHMES cells, a recently established line of immortalized embryonic mesencephalic cells, are the novel in vitro model for studying Parkinson's disease (PD) and dopaminergic neuron biology. Phosphoglyceromutase 5 (PGAM5) is a mitochondrial protein involved in mitophagy, mitochondria dynamics, and other processes importa... | ['Carrier Proteins', 'Cell Differentiation', 'Cell Line, Transformed', 'Gene Expression Regulation', 'Humans', 'Mesencephalon', 'Mitochondrial Proteins', 'Oxidopamine', 'Parkinsonian Disorders', 'Phosphoprotein Phosphatases'] | 25,986,246 | [['D12.776.157'], ['G04.152'], ['A11.251.210.172'], ['G05.308'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A08.186.211.132.659'], ['D12.776.575'], ['D02.092.311.342.478.650', 'D02.455.426.559.389.657.166.175.342.478.650'], ['C10.228.140.079.862', 'C10.228.662.600'], ['D08.811.277.352.650.625']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Combination of PI3K/mTOR inhibition demonstrates efficacy in human chordoma. | BACKGROUND: Chordomas are rare tumors of the axial skeleton for which surgical resection remains the most reliable means of cure. PI-103 is a inhibitor of PI3K/AKT and mTOR activation. This study aims to determine whether the PI3K/mTOR pathway was active in chordomas and whether their inhibition could lead to decreased... | ['Antibiotics, Antineoplastic', 'Antineoplastic Agents', 'Apoptosis', 'Blotting, Western', 'Cell Proliferation', 'Chordoma', 'Cisplatin', 'Doxorubicin', 'Furans', 'Humans', 'Phosphatidylinositol 3-Kinases', 'Phosphoinositide-3 Kinase Inhibitors', 'Protein Kinase Inhibitors', 'Protein Kinases', 'Proto-Oncogene Proteins ... | 19,528,441 | [['D27.505.954.248.106'], ['D27.505.954.248'], ['G04.146.954.035'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['G04.161.750', 'G07.345.249.410.750'], ['C04.557.465.220'], ['D01.210.375', 'D01.625.125', 'D01.710.100'], ['D02.455.426.559.847.562.050.200.175', 'D0... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Pre-vaccination prevalence and distribution of high-risk human papillomavirus (HPV) types in Slovenian women: a cervical cancer screening based study. | To estimate the pre-vaccination prevalence of cervical infections with 14 high-risk human papillomavirus (hr-HPV) types among 20-64 years old Slovenian women screened for cervical cancer in 2010, we consecutively enrolled 4431 women in 16 outpatient gynaecology services. All were screened with Digene Hybrid Capture 2 H... | ['Adult', 'Cervix Uteri', 'DNA, Viral', 'Early Detection of Cancer', 'Female', 'Genotype', 'Humans', 'Middle Aged', 'Molecular Diagnostic Techniques', 'Papillomaviridae', 'Papillomavirus Infections', 'Prevalence', 'Slovenia', 'Virology'] | 22,080,175 | [['M01.060.116'], ['A05.360.319.679.256'], ['D13.444.308.568'], ['E01.390.500'], ['G05.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.370.225.880', 'E05.200.880', 'E05.393.520'], ['B04.280.210.655', 'B04.613.204.655'], ['C01.925.256.650', 'C01.925.928.725'], ['E05.318.308.985.525.750... | ['Named Groups [M]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]', 'Geographicals [Z]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
Immunohistochemical and neurochemical evidence for GABAA receptor heterogeneity between the hypothalamus and cortex. | This study examined both the function of the GABAA receptor complex and the expression of its alpha 1, alpha 2 and alpha 3 subunits within the hypothalamus as compared to that of the cerebral cortex. A large number of different GABAA receptor subunit combinations potentially exist in various brain regions which, presum... | ['Animals', 'Cerebral Cortex', 'Chlorides', 'Diazepam', 'Flunitrazepam', 'Hypothalamus', 'Male', 'Rats', 'Receptors, GABA-A', 'gamma-Aminobutyric Acid'] | 7,873,096 | [['B01.050'], ['A08.186.211.200.885.287.500'], ['D01.210.450.150', 'D01.248.497.158.215'], ['D03.633.100.079.080.070.216'], ['D03.633.100.079.080.070.320'], ['A08.186.211.180.497', 'A08.186.211.200.317.357'], ['B01.050.150.900.649.313.992.635.505.700'], ['D12.776.157.530.400.175.562', 'D12.776.157.530.400.400.100.100',... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Predicting alternative splicing. | Alternative splicing of pre-mRNA is a complex process whose outcome depends on elements reviewed in the previous chapters such as the core spliceosome units, how the core spliceosome units interact between themselves and with other splicing enhancers and repressors, primary sequence motifs, and local RNA secondary stru... | ['Alternative Splicing', 'Codon, Nonsense', 'Conserved Sequence', 'Exons', 'Introns', 'Molecular Biology', 'RNA Precursors', 'RNA Stability', 'Regulatory Sequences, Nucleic Acid'] | 24,549,679 | [['G02.111.760.700.100', 'G03.839.700.100', 'G05.308.700.700.100'], ['D13.444.735.544.355.250.235', 'G05.360.335.355.250.235', 'G05.365.590.195'], ['G02.111.570.580'], ['G05.360.340.024.340.137.232'], ['G05.360.340.024.220.400', 'G05.360.340.024.340.137.515'], ['H01.158.201.636', 'H01.158.273.343.595', 'H01.181.122.650... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
The co-chaperone CHIP is induced in various stresses and confers protection to cells. | The C-terminus of Hsp70 interacting protein (CHIP) is being considered to be a cellular quality control E3 ubiquitin ligase because of its ability to degrade misfolded proteins in association with heat shock chaperones. The neuroprotective role of CHIP also has been implicated in several familial neurodegenerative dise... | ['Adaptor Proteins, Signal Transducing', 'Animals', 'Carrier Proteins', 'Cell Line, Tumor', 'Cell Survival', 'Gene Expression', 'HeLa Cells', 'Humans', 'Leupeptins', 'Molecular Chaperones', 'Peptides', 'RNA, Messenger', 'Reverse Transcriptase Polymerase Chain Reaction', 'Transfection', 'Tunicamycin'] | 17,442,270 | [['D12.644.360.024', 'D12.776.157.057', 'D12.776.476.024'], ['B01.050'], ['D12.776.157'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.346'], ['G05.297'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.456.580'], ['D12.776.580'], ['D12.644'], [... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[A study of the cytochrome composition of microorganisms by their absorption spectra and first derivative spectra]. | The cytochrome composition of Candida mycoderma and Torulopsis candida was studied by means of absorption spectra and spectra of the first derivative which were recorded at the temperature of liquid nitrogen and room temperature. The spectrum of the first derivative provided more information concerning the cytochrome c... | ['Candida', 'Cytochromes', 'Spectrophotometry'] | 945,440 | [['B01.300.107.795.095', 'B01.300.381.147', 'B01.300.930.176'], ['D08.244', 'D12.776.422.220'], ['E05.196.712.726', 'E05.196.867.826']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Measles: how many hospitalised cases are we missing? | We aimed to determine whether the Victorian measles surveillance system had missed hospitalised cases of measles during an inter-epidemic period. We searched the Victorian Inpatient Minimum Dataset (VIMD) for the period 1 January 1997 to 30 June 1998 to identify patients with ICD-9 discharge codes for measles (055). Th... | ['Adult', 'Child', 'Child, Preschool', 'Databases as Topic', 'Epidemiologic Measurements', 'Female', 'Hospitalization', 'Humans', 'Infant', 'Male', 'Measles', 'Population Surveillance', 'Victoria'] | 11,596,716 | [['M01.060.116'], ['M01.060.406'], ['M01.060.406.448'], ['L01.313.500.750.300.188', 'L01.470.750'], ['N06.850.505'], ['E02.760.400', 'N02.421.585.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['C01.925.782.580.600.500.500'], ['E05.318.308.980.438.700', 'N05.715.360.300.800.438.625', 'N06.850.... | ['Named Groups [M]', 'Information Science [L]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
Hydroxyl radical recycling in isoprene oxidation driven by hydrogen bonding and hydrogen tunneling: the upgraded LIM1 mechanism. | The Leuven isoprene mechanism, proposed earlier to aid in rationalizing the unexpectedly high hydroxyl radical (OH) concentrations in isoprene-rich, low-nitric-oxide (NO) regions ( Peeters ; et al. Phys. Chem. Chem. Phys . 2009 , 11 , 5935 ), is presented in an upgraded and extended version, LIM1. The kinetics of the c... | ['Butadienes', 'Hemiterpenes', 'Hydrogen', 'Hydrogen Bonding', 'Hydroxyl Radical', 'Molecular Structure', 'Oxidation-Reduction', 'Pentanes', 'Quantum Theory'] | 25,010,574 | [['D02.455.326.271.665.146.240'], ['D02.455.849.486'], ['D01.268.406', 'D01.362.340'], ['G02.282'], ['D01.045.250.357', 'D01.248.497.158.459.300', 'D01.339.431.249'], ['G02.111.570', 'G02.466'], ['G02.700', 'G03.295.531'], ['D02.455.326.146.770'], ['H01.671.579.800']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
[Characterization of Cr Tolerance and Accumulation in Lolium perenne | Considering the serious pollution of heavy metal-chromium (Cr) in soil, there is an urgent need for effective selection of Cr-tolerant plant species. In order to gain fundamental insights into the tolerance and accumulation capabilities of Lolium perenne L. and Pharibitis purpurea(L.) Voigt under Cr stress, a pot exper... | ['Biodegradation, Environmental', 'Chromium', 'Lolium', 'Plant Roots', 'Soil', 'Soil Pollutants'] | 29,964,442 | [['N06.230.080.600.500', 'N06.850.460.375.500'], ['D01.268.556.175', 'D01.268.956.124', 'D01.552.544.175'], ['B01.650.940.800.575.912.250.822.500'], ['A18.400'], ['D20.721', 'G01.311.820', 'G16.500.275.815', 'N06.230.600'], ['D27.888.284.756']] | ['Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Phase II study of the proteasome inhibitor bortezomib (PS-341) in patients with metastatic neuroendocrine tumors. | PURPOSE: This phase II study was undertaken to assess objective response, toxicity, tumor marker response, and pharmacodynamics of bortezomib in patients with metastatic neuroendocrine (carcinoid and islet cell) tumors.EXPERIMENTAL DESIGN: A total of 16 patients with measurable metastatic carcinoid (n=12) or islet cell... | ['Adult', 'Aged', 'Antineoplastic Agents', 'Biomarkers, Tumor', 'Boronic Acids', 'Bortezomib', 'Carcinoid Tumor', 'Female', 'Humans', 'Male', 'Maximum Tolerated Dose', 'Middle Aged', 'Neoplasm Metastasis', 'Neuroendocrine Tumors', 'Pancreatic Neoplasms', 'Protease Inhibitors', 'Proteasome Inhibitors', 'Pyrazines', 'Tim... | 15,447,997 | [['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.248'], ['D23.101.140'], ['D01.029.260.110', 'D01.132.285', 'D02.203.200'], ['D01.029.260.110.500', 'D01.132.285.500', 'D02.203.200.500', 'D03.383.679.450'], ['C04.557.465.625.650.200', 'C04.557.470.200.025.200', 'C04.557.580.625.650.200'], ['B01.050.150.900.649.313.9... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Processing and surface presentation of the Mycoplasma hyorhinis variant lipoprotein VlpC. | The variant surface lipoprotein VlpC of Mycoplasma hyorhinis was shown to be processed by cleavage of a characteristic prokaryotic prolipoprotein signal peptide. In addition, a vlpC::phoA fusion protein expressed and translocated in Escherichia coli was recognized by surface-binding monoclonal antibodies, which identif... | ['Amino Acid Sequence', 'Antigens, Bacterial', 'Bacterial Proteins', 'Base Sequence', 'Cloning, Molecular', 'Epitopes', 'Escherichia coli', 'Lipoproteins', 'Molecular Sequence Data', 'Mycoplasma', 'Protein Sorting Signals'] | 7,512,554 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D23.050.161'], ['D12.776.097'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.393.220'], ['D23.050.550'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D10.532', 'D12.776.521'], ['L01.453.245.667'], ['B03.440.860.580.553.553'], ['D12.644.770'... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
A methodology for centrifuge selection for the separation of high solids density cell broths by visualisation of performance using windows of operation. | Expression systems capable of growing to high cell densities are now readily available and are popular due to the benefits of increased product concentration. However, such high solids density cultures pose a major challenge for bioprocess engineers as choosing the right separation equipment and operating it at optimal... | ['Biotechnology', 'Cell Separation', 'Centrifugation', 'Computers', 'Equipment Design', 'Fermentation', 'Fungal Proteins', 'Industrial Microbiology', 'Pichia', 'Software'] | 16,865,731 | [['H01.158.550', 'J01.897.120'], ['E01.370.225.500.363', 'E05.200.500.363', 'E05.242.363'], ['E05.181'], ['L01.224.230.260'], ['E05.320'], ['G02.111.158.249', 'G03.191.249'], ['D12.776.354'], ['H01.158.273.540.460', 'J01.897.120.460'], ['B01.300.107.795.700', 'B01.300.930.600'], ['L01.224.900']] | ['Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 |
Identification, biological activity, and mechanism of the anti-ischemic quinolone analog. | The quinolone analog SQ-4004 has been identified as a potentially excellent anti-ischemic agent, which exhibited highly potent efficacy in reducing infarct volume size in vivo rat MCAO model (32.1% at 0.01mg/kg) and potent cardioprotective effect at myocardial infarction in vivo model (26.6% at 0.01mg/kg) while it exhi... | ['Animals', 'Anti-Bacterial Agents', 'Brain Ischemia', 'Cell Line, Tumor', 'Cell Survival', 'Disease Models, Animal', 'Humans', 'Models, Biological', 'Molecular Structure', 'Myocardial Infarction', 'Quinolines', 'Rats', 'Structure-Activity Relationship'] | 17,698,362 | [['B01.050'], ['D27.505.954.122.085'], ['C10.228.140.300.150', 'C14.907.253.092'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.346'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.395'], ['G02.111.570', 'G02.466'], ['C14.280.647.500', 'C14.907.585.500', 'C23... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Covariations of unhealthy weight loss behaviors and other high-risk behaviors among adolescents. | OBJECTIVES: To determine if unhealthy weight loss methods are associated with other health-compromising behaviors among adolescents and to examine covariation patterns across gender and age groups.STUDY DESIGN AND PARTICIPANTS: The study sample was drawn from a larger population of 123 132 adolescents in the 6th, 9th, ... | ['Adolescent', 'Adolescent Behavior', 'Alcohol Drinking', 'Female', 'Humans', 'Juvenile Delinquency', 'Male', 'Marijuana Smoking', 'Minnesota', 'Risk-Taking', 'Smoking', 'Suicide, Attempted', 'Surveys and Questionnaires', 'Weight Loss'] | 8,603,226 | [['M01.060.057'], ['F01.145.022'], ['F01.145.317.269'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I01.880.735.479'], ['F01.145.610.875', 'F01.145.805.250.500'], ['Z01.107.567.875.350.510', 'Z01.107.567.875.510.510'], ['F01.145.722'], ['F01.145.805'], ['F01.145.126.980.875.600', 'I01.880.735.856.600'], ['E05.31... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Stage I-III colon cancer patients with tumor deposits behave similarly to stage IV patients. Cross-section analysis of 392 patients. | BACKGROUND AND OBJECTIVES: Tumor deposits (TDs) are associated with adverse prognostic factors and decreased survival in colorectal cancer. However, controversy exists regarding their definition, evaluation, and staging categories. This study aimed to determine the survival and recurrence impact of the TD in colon aden... | ['Adenocarcinoma', 'Adult', 'Aged', 'Colonic Neoplasms', 'Cross-Sectional Studies', 'Female', 'Humans', 'Male', 'Margins of Excision', 'Middle Aged', 'Neoplasm Invasiveness', 'Neoplasm Recurrence, Local', 'Neoplasm Staging', 'Survival Analysis', 'Survival Rate'] | 31,017,669 | [['C04.557.470.200.025'], ['M01.060.116'], ['M01.060.116.100'], ['C04.588.274.476.411.307.180', 'C06.301.371.411.307.180', 'C06.405.249.411.307.180', 'C06.405.469.158.356.180', 'C06.405.469.491.307.180'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.649.313.988.400.11... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Bilateral gluteal advancement flap for treatment of recurrent sacrococcygeal pilonidal disease: A prospective cohort study. | BACKGROUND: There is controversy about the best surgical approach for recurrent pilonidal disease (PND) up till now. This study aims to evaluate the efficacy of bilateral gluteal fascio-myo-cutaneous advancement flap (BGFMCF) in treatment of recurrent PND.PATIENT AND METHODS: Forty patients (35 males, 5 females) with r... | ['Adult', 'Body Mass Index', 'Buttocks', 'Female', 'Humans', 'Length of Stay', 'Male', 'Neoplasm Recurrence, Local', 'Operative Time', 'Patient Satisfaction', 'Photography', 'Pilonidal Sinus', 'Postoperative Complications', 'Prospective Studies', 'Quality of Life', 'Reconstructive Surgical Procedures', 'Recurrence', 'S... | 26,975,846 | [['M01.060.116'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['A01.378.610.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.760.400.480', 'N02.421.585.400.480'], ['C04.697.655', 'C23.550.727.655'], ['E04.614.374.500', 'N02.421.585.753.374.500'], ['F01.100.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Outcome of adrenocortical tumors in children. | PURPOSE: This study reviews adrenocortical tumors in children to determine factors that significantly affect outcome.METHODS: An institutional review board-approved retrospective review from 1976 to 2005 identified 23 patients younger than 19 years old with histologic confirmation of adrenocortical carcinoma (ACC) and ... | ['Adenoma', 'Adolescent', 'Adrenal Cortex Neoplasms', 'Adrenalectomy', 'Adrenocortical Carcinoma', 'Chemotherapy, Adjuvant', 'Child', 'Child, Preschool', 'Female', 'Humans', 'Infant', 'Infant, Newborn', 'Male', 'Neoplasm Staging', 'Radiotherapy, Adjuvant', 'Retrospective Studies', 'Survival Rate', 'Treatment Outcome'] | 18,485,950 | [['C04.557.470.035'], ['M01.060.057'], ['C04.588.322.078.265', 'C19.053.098.265', 'C19.053.347.500', 'C19.344.078.265'], ['E04.270.115'], ['C04.557.470.200.025.152', 'C04.588.322.078.265.750', 'C19.053.098.265.750', 'C19.053.347.500.750', 'C19.344.078.265.750'], ['E02.186.170', 'E02.319.170'], ['M01.060.406'], ['M01.06... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Effectiveness of intraperitoneal hyperthermo-chemotherapy for malignant peritoneal mesothelioma and estimation of its effect by repeated FDG-PET: a case report. | Malignant peritoneal mesothelioma is a rare neoplasm derived from the peritoneum of the abdominal cavity. Here, we report on a case of malignant peritoneal mesothelioma that expanded aggressively after initial surgery, followed by successful treatment with cytoreductive surgery, intra-abdominal hyperthermo-chemotherapy... | ['Combined Modality Therapy', 'Female', 'Fluorodeoxyglucose F18', 'Humans', 'Hyperthermia, Induced', 'Mesothelioma', 'Middle Aged', 'Peritoneal Neoplasms', 'Positron-Emission Tomography', 'Radiopharmaceuticals'] | 21,830,405 | [['E02.186'], ['D09.254.229.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.565'], ['C04.557.470.035.510', 'C04.557.470.660.510'], ['M01.060.116.630'], ['C04.588.033.513', 'C04.588.274.780', 'C06.301.780', 'C06.844.620'], ['E01.370.350.350.800.700', 'E01.370.350.600.350.800.399', 'E01.370.350.710.800.399'... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Insomnia in older adults with chronic obstructive pulmonary disease (COPD) in Hong Kong: a case-control study. | This study aimed to determine the frequency and sociodemographic/clinical correlates of insomnia in Chinese patients aged ?60 years suffering from chronic obstructive pulmonary disease (COPD). In this case-control study of 142 outpatients with COPD and 218 sex- and age-matched control subjects, COPD patients were recru... | ['Activities of Daily Living', 'Aged', 'Aged, 80 and over', 'Case-Control Studies', 'Comorbidity', 'Depression', 'Disease Progression', 'Female', 'Hong Kong', 'Humans', 'Male', 'Middle Aged', 'Prevalence', 'Prospective Studies', 'Pulmonary Disease, Chronic Obstructive', 'Quality of Life', 'Sleep Initiation and Maintena... | 24,378,014 | [['E02.760.169.063.500.067', 'E02.831.067', 'I03.050', 'N02.421.784.110'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['N05.715.350.225', 'N06.850.490.687'], ['F01.145.126.350'], ['C23.550.291.656'], ['Z01.252.474.164.450'], ['B01.050.150... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Geographicals [Z]', 'Organisms [B]', 'Humanities [K]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Physical therapy education and provision in Cambodia: a framework for choice of systems for development projects. | PURPOSE: Rehabilitation agencies, policy makers and donors are faced with the choice of the level of rehabilitation provider to promote in developing countries. This is particularly the case after conflict when new systems are considered and the need for rehabilitation becomes a priority. The complete decimation of med... | ['Cambodia', 'Community Health Services', 'Humans', 'Models, Organizational', 'Organizational Case Studies', 'Physical Therapy Specialty', 'Social Change', 'Warfare'] | 17,577,725 | [['Z01.252.145.182'], ['N02.421.143'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.670', 'N04.452.534'], ['N03.349.380.710', 'N05.715.360.455'], ['H02.010.625'], ['I01.076.201.450.776', 'I01.880.853.400', 'N01.824.737'], ['I01.880.735.950.500']] | ['Geographicals [Z]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 |
Definition of onset in the development of onset-based alcoholism typologies. | Age of onset of alcoholism is gaining prominence as an explanatory construct in the development of models of alcoholism. Recently, at least one investigator has cited its potential as a simple means for deriving a typological classification scheme that could have great impact, both in terms of future research and in de... | ['Adult', 'Age Factors', 'Aged', 'Alcoholism', 'Female', 'Humans', 'Male', 'Middle Aged', 'Models, Psychological', 'Semantics', 'Sex Factors'] | 3,347,081 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['C25.775.100.250', 'F03.900.100.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.599.695'], ['L01.559.598.745'], ['N05.715.350.675', 'N06.850.490.875']] | ['Named Groups [M]', 'Health Care [N]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Therapeutic deep brain stimulation in Parkinsonian rats directly influences motor cortex. | Much recent discussion about the origin of Parkinsonian symptoms has centered around the idea that they arise with the increase of beta frequency waves in the EEG. This activity may be closely related to an oscillation between subthalamic nucleus (STN) and globus pallidus. Since STN is the target of deep brain stimulat... | ['Action Potentials', 'Adrenergic Agents', 'Afferent Pathways', 'Animals', 'Antiparkinson Agents', 'Apomorphine', 'Biophysics', 'Brain Mapping', 'Deep Brain Stimulation', 'Disease Models, Animal', 'Electrodes, Implanted', 'Electroencephalography', 'Evoked Potentials, Motor', 'Functional Laterality', 'Locomotion', 'Male... | 23,217,750 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['D27.505.519.625.050', 'D27.505.696.577.050'], ['A08.612.220'], ['B01.050'], ['D27.505.954.427.090.050'], ['D03.132.098.038.290', 'D03.633.100.531.085.030.290', 'D03.633.400.095.290'], ['H01.158.344', 'H01.671.100'], ['E01.370.350.578.875.500', 'E01.370.376.537.6... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
[The influence of the quality of proteins in fluoride bone fixation]. | 45 rats Wistar, 30 days old, were divided into five groups, receiving different diets: casein, bean and wheat flour. The last two diets were supplemented or not by D-L Methionine and D-L Lysine, respectively. Diets and fluoridated water (25 ppm) were given "ad libitum" for 28 days. After this period of experience, the ... | ['Animals', 'Bone and Bones', 'Caseins', 'Dental Caries', 'Dietary Proteins', 'Flour', 'Fluorides', 'Food, Fortified', 'Nutritional Requirements', 'Protein Deficiency', 'Rats', 'Triticum'] | 614,821 | [['B01.050'], ['A02.835.232', 'A10.165.265'], ['D12.776.256.159.750.207', 'D12.776.744.150'], ['C07.793.720.210'], ['D12.776.256', 'G07.203.300.428', 'J02.500.428'], ['G07.203.300.484', 'J02.500.484'], ['D01.248.497.158.380', 'D01.303.350.300'], ['G07.203.300.515', 'J02.500.515'], ['G07.203.650.620'], ['C18.654.521.500... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
[The significance of immature granulocytes in diagnostic of infectious inflammatory processes in cardiosurgery patients]. | The evaluation was implemented concerning the values of automated parameter "immature granulocytes" in cardiosurgery patients. It is demonstrated that amount of immature granulocytes in peripheral blood exceeding 2% indicates development of infectious inflammatory process (sepsis). The monitoring of amount of immature ... | ['Female', 'Granulocyte Precursor Cells', 'Heart Valve Prosthesis', 'Humans', 'Prosthesis-Related Infections'] | 25,338,460 | [['A11.148.350.350', 'A11.148.378.590.675.500', 'A11.627.340.360', 'A11.627.635.675.500', 'A11.872.378.590.635.500', 'A15.378.316.340.350', 'A15.378.316.378.590.675.500'], ['E07.695.310'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C01.685', 'C23.550.767.868']] | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of functionalization of carbon nanotubes on their dispersion in an ethylene glycol-water binary mixture--a molecular dynamics and ONIOM investigation. | The present work utilizes classical molecular dynamics simulations to investigate the covalent functionalization of carbon nanotubes (CNTs) and their interaction with ethylene glycol (EG) and water molecules. The MD simulation reveals the dispersion of functionalized carbon nanotubes and the prevention of aggregation i... | ['Ethylene Glycol', 'Models, Molecular', 'Molecular Dynamics Simulation', 'Nanotubes, Carbon', 'Quantum Theory', 'Water'] | 25,308,102 | [['D02.033.455.250.268'], ['E05.599.595'], ['E05.599.595.500', 'G02.111.570.895', 'L01.224.160.500'], ['D01.268.150.250.500', 'J01.637.512.850.500'], ['H01.671.579.800'], ['D01.045.250.875', 'D01.248.497.158.459.650', 'D01.650.550.925']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Technology, Industry, and Agriculture [J]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 |
Immunopathological characterization of cryptoglandular anal fistula: a pilot study investigating its pathogenesis. | AIM: The pathogenesis of cryptoglandular anal fistula (AF) is still under debate. Tissue inflammation could play a primary role. The pathological process of epithelial mesenchymal transition (EMT) might be involved but has never been investigated.METHOD: In a prospective pilot study, 12 patients with an AF had a fistul... | ['Adult', 'Anal Canal', 'Antigens, CD', 'Blotting, Western', 'Cadherins', 'Epithelial-Mesenchymal Transition', 'Female', 'Humans', 'Immunohistochemistry', 'Inflammation Mediators', 'Interleukin-1beta', 'Interleukin-8', 'Male', 'Pilot Projects', 'Prospective Studies', 'Real-Time Polymerase Chain Reaction', 'Rectal Fistu... | 27,649,390 | [['M01.060.116'], ['A03.556.124.526.070', 'A03.556.249.249.070'], ['D23.050.301.264.035', 'D23.101.100.110'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['D12.776.395.550.200.200', 'D12.776.543.550.200.200', 'D23.050.301.350.200'], ['G04.356.500'], ['B01.050.150... | ['Named Groups [M]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Behavioral, central monoaminergic and hypothalamo-pituitary-adrenal axis correlates of fear-conditioned analgesia in rats. | Fear-conditioned analgesia is an important survival response which is expressed upon re-exposure to a context previously paired with a noxious stimulus. The aim of the present study was to characterize further the behavioral, monoaminergic and hypothalamo-pituitary-adrenal axis alterations associated with expression of... | ['3,4-Dihydroxyphenylacetic Acid', 'Analgesia', 'Animals', 'Behavior, Animal', 'Biogenic Monoamines', 'Brain', 'Conditioning, Psychological', 'Corticosterone', 'Disease Models, Animal', 'Dopamine', 'Electric Stimulation', 'Fear', 'Hypothalamo-Hypophyseal System', 'Male', 'Neural Pathways', 'Pain', 'Pain Measurement', '... | 16,426,764 | [['D02.241.223.601.220'], ['E03.091'], ['B01.050'], ['F01.145.113'], ['D02.092.211.215'], ['A08.186.211'], ['F02.463.425.179'], ['D04.210.500.745.745.654.237', 'D06.472.040.585.353.237'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['D02.092.211.215.406', 'D02.092.311.342', 'D02.455.426.559.389.657.166.175.342'], ['... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Airway epithelium and nitric oxide]. | To measure the generation of nitric oxide (NO) by airway epithelial cells and to study the physiological role of NO in the regulation of epithelial functions, we studied ciliary motility of rabbit cultured tracheal epithelium in vitro and ion transport across tracheal mucosa in vivo. Isoproterenol dose-dependently incr... | ['Animals', 'Cells, Cultured', 'Chlorine', 'Cilia', 'Dose-Response Relationship, Drug', 'Epithelial Cells', 'Epithelium', 'Ion Transport', 'Isoproterenol', 'Nitric Oxide', 'Rabbits', 'Tachykinins', 'Trachea'] | 8,752,508 | [['B01.050'], ['A11.251'], ['D01.268.380.150', 'D01.362.225'], ['A11.284.180.165'], ['G07.690.773.875', 'G07.690.936.500'], ['A11.436'], ['A10.272'], ['G03.143.500'], ['D02.033.100.291.439', 'D02.092.063.291.439', 'D02.092.311.649', 'D02.455.426.559.389.657.166.175.649'], ['D01.339.387', 'D01.625.550.500', 'D01.625.700... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Religiosity and physical and emotional functioning among African American and White colorectal and lung cancer patients. | The literature suggests that religiosity helps cope with illness. The present study examined the role of religiosity in functioning among African Americans and Whites with a cancer diagnosis. Patients were recruited from an existing study and mailed a religiosity survey. Participants (N = 269; 36% African American, 56%... | ['Adaptation, Psychological', 'Adult', 'African Americans', 'Aged', 'Aged, 80 and over', 'Colorectal Neoplasms', 'Depression', 'European Continental Ancestry Group', 'Female', 'Health Status', 'Humans', 'Lung Neoplasms', 'Male', 'Mental Health', 'Middle Aged', 'Multivariate Analysis', 'Religion', 'Surveys and Questionn... | 21,966,724 | [['F01.058'], ['M01.060.116'], ['M01.686.508.100.100', 'M01.686.754.100'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C04.588.274.476.411.307', 'C06.301.371.411.307', 'C06.405.249.411.307', 'C06.405.469.158.356', 'C06.405.469.491.307', 'C06.405.469.860.180'], ['F01.145.126.350'], ['M01.686.508.400'], ['I01.240.425... | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Humanities [K]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Simultaneous removal of colour, phosphorus and disinfection from treated wastewater using an agent synthesized from amorphous silica and hydrated lime. | An agent synthesized from amorphous silica and hydrated lime (CSH-lime) was investigated for its ability to simultaneously remove the colour, phosphorus and disinfection from the effluents from wastewater treatment plants on swine farms. CSH-lime removed the colour and phosphate from the effluents, with the colour-remo... | ['Calcium Compounds', 'Color', 'Disinfection', 'Oxides', 'Phosphorus', 'Silicon Dioxide', 'Waste Water', 'Water', 'Water Purification'] | 23,837,353 | [['D01.146'], ['G01.590.540.199'], ['N06.850.780.200.450.850.375'], ['D01.248.497.158.685', 'D01.650.550'], ['D01.268.666'], ['D01.578.750', 'D01.650.550.825', 'D01.837.725'], ['D20.944.932', 'N06.850.460.710.865'], ['D01.045.250.875', 'D01.248.497.158.459.650', 'D01.650.550.925'], ['N06.850.780.200.800.800.900.900', '... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
A simple method to provide a shuttling plasmid for delivery to other host ascertained by prolonged stability of extracellular plasmid DNA released from Escherichia coli K12 endA mutant, deficient in major endonuclease. | Escherichia coli lyses by lambda phage propagation. Circular plasmid DNA was present during E. coli lysis as an extracellular plasmid DNA (excpDNA) that was stable enough to transform coexisting competent Bacillus subtilis cells. Detailed investigations unveiled that excpDNA is transient in both quality and quantity, w... | ['Bacillus subtilis', 'Bacteriophage lambda', 'DNA, Bacterial', 'Deoxyribonuclease I', 'Escherichia coli K12', 'Escherichia coli Proteins', 'Gene Knockout Techniques', 'Lysogeny', 'Mutation', 'Plasmids', 'Rec A Recombinases', 'Transformation, Bacterial', 'Virus Replication'] | 23,055,537 | [['B03.300.390.400.158.218.725', 'B03.353.500.100.218.725', 'B03.510.100.100.218.725', 'B03.510.415.400.158.218.725', 'B03.510.460.410.158.218.725'], ['B04.123.150.800.230', 'B04.123.205.230', 'B04.280.090.800.230'], ['D13.444.308.212'], ['D08.811.277.352.335.350.250'], ['B03.440.450.425.325.300.360', 'B03.660.250.150.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of epidermal growth factor on deoxyribonucleic acid synthesis and stomach weight in hypophysectomized adult mice. | Epidermal growth factor (EGF) or saline was administered intraperitoneally to hypophysectomized adult male CD2F1 mice or intact controls at 0700 hr. Subgroups of mice were killed at 4, 8, or 12 hr after injection. EGF was shown to stimulate [3H]TdR incorporation into DNA into several organs as previously reported. The ... | ['Animals', 'DNA Replication', 'Epidermal Growth Factor', 'Esophagus', 'Fasting', 'Gastric Mucosa', 'Hypophysectomy', 'Male', 'Mice', 'Organ Size', 'Stomach', 'Time Factors'] | 6,334,278 | [['B01.050'], ['G02.111.225', 'G05.226'], ['D06.472.317.350', 'D12.644.276.382.500', 'D12.776.467.382.500', 'D23.529.382.500'], ['A03.556.875.500'], ['F01.145.407.400', 'G07.203.650.240.587', 'G07.203.650.353.400'], ['A03.556.875.875.440', 'A10.615.550.291'], ['E04.270.532', 'E04.525.400'], ['B01.050.150.900.649.313.99... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vascular endothelial growth factor promotes physical wound repair and is anti-apoptotic in primary distal lung epithelial and A549 cells. | OBJECTIVE: There is evidence to suggest a beneficial role for growth factors, including vascular endothelial growth factor (VEGF), in tissue repair and proliferation after injury within the lung. Whether this effect is mediated predominantly by actions on endothelial cells or epithelial cells is unknown. This study tes... | ['Adult', 'Apoptosis', 'Caspase 3', 'Cells, Cultured', 'Epithelial Cells', 'Humans', 'Lung', 'Receptors, Vascular Endothelial Growth Factor', 'Vascular Endothelial Growth Factor A', 'Wound Healing'] | 17,855,831 | [['M01.060.116'], ['G04.146.954.035'], ['D08.811.277.656.262.500.126.350.300', 'D08.811.277.656.300.200.126.350.300', 'D12.644.360.075.405.350.300', 'D12.776.476.075.405.350.300'], ['A11.251'], ['A11.436'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A04.411'], ['D08.811.913.696.620.682.725.400.950', 'D12.776.54... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Ubiquitin in stressed chicken embryo fibroblasts. | Ubiquitin, a small 76-amino acid protein which is highly conserved in eukaryotic cells, occurs in several forms other than the free polypeptide. Among these are protein conjugates in which ubiquitin is covalently linked in lysylpeptide bond to lysl residues of other proteins and fusion proteins in which the amino-termi... | ['Animals', 'Arsenic', 'Arsenites', 'Cells, Cultured', 'Chick Embryo', 'Fibroblasts', 'Heat-Shock Proteins', 'Hot Temperature', 'Recombinant Fusion Proteins', 'Stress, Physiological', 'Ubiquitins'] | 2,828,367 | [['B01.050'], ['D01.268.513.249'], ['D01.075.050', 'D01.248.497.158.055'], ['A11.251'], ['A13.350.150', 'A16.331.200'], ['A11.329.228'], ['D12.776.580.216'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.775.710.380', 'N06.230.300.100.725.232', 'N06.230.300.100.725.710.380'], ['D12.776.828.300'], ['G0... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
An in silico insight into novel therapeutic interaction of LTNF peptide-LT10 and design of structure based peptidomimetics for putative anti-diabetic activity. | Lethal Toxin Neutralizing Factor (LTNF) obtained from Opossum serum (Didephis virginiana) is known to exhibit toxin-neutralizing activity for envenomation caused by animals, plants and bacteria. Small synthetic peptide- LT10 (10mer) derived from N-terminal fraction of LTNF exhibit similar anti-lethal and anti-allergic ... | ['Animals', 'Diabetes Mellitus, Type 2', 'Drug Design', 'Hypoglycemic Agents', 'Insulysin', 'Molecular Docking Simulation', 'Molecular Dynamics Simulation', 'Opossums', 'Peptide Fragments', 'Peptidomimetics', 'Structure-Activity Relationship'] | 25,816,209 | [['B01.050'], ['C18.452.394.750.149', 'C19.246.300'], ['E05.290.500', 'H01.158.703.007.338.500', 'H01.181.466.338.500'], ['D27.505.696.422'], ['D08.811.277.656.300.480.300', 'D08.811.277.656.675.374.300'], ['E05.599.595.249', 'L01.224.160.249'], ['E05.599.595.500', 'G02.111.570.895', 'L01.224.160.500'], ['B01.050.150.9... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Information Science [L]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Novel approach to molecular cloning and polynucleotide synthesis using vaccinia DNA topoisomerase. | Construction of chimaeric DNA molecules in vitro relies traditionally on two enzymatic steps catalyzed by separate protein components. Site-specific restriction endonucleases are used to generate linear DNAs with defined termini that can then be joined covalently at their ends via the action of DNA ligase. A novel appr... | ['Base Sequence', 'Cloning, Molecular', 'DNA Topoisomerases, Type I', 'DNA, Recombinant', 'Molecular Sequence Data', 'Polynucleotides', 'Vaccinia virus'] | 7,798,275 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.393.220'], ['D08.811.399.403.483', 'D12.776.157.687.375', 'D12.776.660.720.375'], ['D13.444.308.460'], ['L01.453.245.667'], ['D13.695.578'], ['B04.280.650.160.650.900']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Smac mimetic promotes glioblastoma cancer stem-like cell differentiation by activating NF-êB. | Recently, a broader role of inhibitor of apoptosis (IAP) proteins besides their antiapoptotic functions has been described. Therefore, we investigated the effect of non-toxic concentrations of the small-molecule Smac mimetic BV6, which antagonizes IAP proteins, on differentiation of cancer stem-like cells (CSLCs) deriv... | ['Animals', 'Apoptosis', 'Brain Neoplasms', 'Cell Differentiation', 'Cell Line, Tumor', 'Disease Models, Animal', 'Glioblastoma', 'Humans', 'Mice', 'Mice, Nude', 'NF-kappa B', 'Neoplastic Stem Cells', 'Oligopeptides', 'Signal Transduction', 'Xenograft Model Antitumor Assays'] | 24,488,095 | [['B01.050'], ['G04.146.954.035'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['G04.152'], ['A11.251.210.190', 'A11.251.860.180'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['C04.557.465.625.600.380.080.335', 'C04.557.470.670.380.080.335', 'C04.557.580.625.600.380.080.335'], ['B01.050.150.900.6... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The prevalence of deafness-associated mutations in neonates: A meta-analysis of clinical trials. | OBJECTIVE: The causative genes associated with autosomal recessive non-syndromic hearing loss (ARNSHL) have been identified, in order of prevalence are GJB2, SLC26A4, MYO15A, OTOF, CDH23, and TMC1. To evaluate the prevalence of deafness-associated mutations in neonates and the clinical value of screening, we performed ... | ['Asian Continental Ancestry Group', 'China', 'Clinical Trials as Topic', 'Deafness', 'Female', 'Genetic Testing', 'Humans', 'Infant, Newborn', 'Male', 'Mutation', 'Pregnancy', 'Prevalence'] | 30,878,560 | [['M01.686.508.200'], ['Z01.252.474.164'], ['E05.318.372.250.250', 'N05.715.360.330.250.250', 'N06.850.520.450.250.250'], ['C09.218.458.341.186', 'C10.597.751.418.341.186', 'C23.888.592.763.393.341.186'], ['E01.370.225.562', 'E05.200.562', 'E05.393.435', 'N02.421.308.430', 'N02.421.726.233.221'], ['B01.050.150.900.649.... | ['Named Groups [M]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Non-coated multiparticulate matrix systems for colon targeting. | BACKGROUND: Colon specific drug delivery can significantly improve the efficacy of local treatments of inflammatory bowel diseases. Film coatings containing the starch derivative Nutriose have recently been reported to minimize 5-ASA release in media simulating the upper gastro intestinal tract (GIT), while releasing t... | ['Colon', 'Delayed-Action Preparations', 'Drug Compounding', 'Drug Delivery Systems', 'Excipients', 'Humans', 'Inflammatory Bowel Diseases', 'Particle Size', 'Polysaccharides', 'Tablets'] | 21,417,601 | [['A03.556.124.526.356', 'A03.556.249.249.356'], ['D26.255.210', 'E02.319.300.253'], ['E05.916.270'], ['E02.319.300'], ['D26.650.700.419', 'D27.720.744.770.419'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C06.405.205.731', 'C06.405.469.432'], ['G02.712'], ['D09.698'], ['D26.255.830']] | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A regularization corrected score method for nonlinear regression models with covariate error. | Many regression analyses involve explanatory variables that are measured with error, and failing to account for this error is well known to lead to biased point and interval estimates of the regression coefficients. We present here a new general method for adjusting for covariate error. Our method consists of an approx... | ['Breast Neoplasms', 'Computer Simulation', 'Data Interpretation, Statistical', 'Female', 'Humans', 'Motor Activity', 'Regression Analysis'] | 23,379,851 | [['C04.588.180', 'C17.800.090.500'], ['L01.224.160'], ['E05.245.380', 'E05.318.740.300', 'L01.313.500.750.190.380', 'N05.715.360.750.300', 'N06.850.520.830.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.632', 'G11.427.410.698'], ['E05.318.740.750', 'N05.715.360.750.695', 'N06.850.520.830.750']] | ['Diseases [C]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Crystallization and preliminary X-ray crystallographic analysis of the rhesus macaque MHC class I molecule Mamu-B*17 complexed with an immunodominant SIVmac239 Env epitope. | Long-term nonprogression during simian immunodeficiency virus (SIV) infection has been strongly associated with the major histocompatibility complex (MHC) class I allele Mamu-B*17. Here, a complex of rhesus macaque Mamu-B*17 with rhesus macaque â2-microglobulin (â2m) and an immunodominant peptide (SIVmac239 Env241-251;... | ['Animals', 'Crystallization', 'Crystallography, X-Ray', 'Histocompatibility Antigens Class I', 'Immunodominant Epitopes', 'Macaca mulatta'] | 23,722,842 | [['B01.050'], ['E05.196.300', 'G02.171'], ['E05.196.309.742.225'], ['D12.776.395.550.489', 'D12.776.543.550.439', 'D23.050.301.500.100', 'D23.050.705.552.100'], ['D23.050.550.500'], ['B01.050.150.900.649.313.988.400.112.199.120.510.550']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Fluid dipping technology of chimpanzees in Como? National Park, Ivory Coast. | Over a 6 month period during the dry season, from the end of October 2014 to the beginning of May 2015, we studied tool use behavior of previously unstudied and non-habituated savanna chimpanzees (Pan troglodytes verus) living in the Como? National Park, Ivory Coast (CI). We analyzed all the stick tools and leaf-sponge... | ['Animals', "Cote d'Ivoire", 'Feeding Behavior', 'Female', 'Male', 'Pan troglodytes', 'Parks, Recreational', 'Tool Use Behavior'] | 28,002,878 | [['B01.050'], ['Z01.058.290.190.272'], ['F01.145.113.547', 'F01.145.407', 'G07.203.650.353'], ['B01.050.150.900.649.313.988.400.112.400.620'], ['J03.925.680'], ['F01.145.113.840']] | ['Organisms [B]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 |
Comparison of severely and profoundly hearing-impaired children's amplification preferences with the NAL-RP and the DSL 3.0 prescriptions. | Prompted by a recent paper in this journal (Snik et al., 1995), this communication compares the gain and frequency response preferred by a group of 21 severely and profoundly hearing-impaired children (37 test ears) to the NAL-RP and the DSL 3.0 hearing aid prescriptions. The results support the findings of Snik et al.... | ['Adolescent', 'Audiometry', 'Child', 'Deafness', 'Hearing Aids', 'Humans', 'Severity of Illness Index'] | 9,428,030 | [['M01.060.057'], ['E01.370.382.375.060'], ['M01.060.406'], ['C09.218.458.341.186', 'C10.597.751.418.341.186', 'C23.888.592.763.393.341.186'], ['E07.305.906.500', 'E07.814.458'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.980.438.475.456.500', 'N05.715.360.300.800.438.375.364.500', 'N06.850.520.308.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Treatment of complex bone nonunion with external skeletal fixation]. | OBJECTIVES: To summarize the experience in the treatment of 112 cases of complex bone nonunion from 1982 to 1999 in our department and introduce the technique of external skeletal fixation.METHODS: The two fragment ends of all cases were fixed under pressure with half-ring sulcated external skeletal fixator. Those case... | ['Adolescent', 'Adult', 'Aged', 'Child', 'Child, Preschool', 'Female', 'Fracture Fixation', 'Fracture Healing', 'Fractures, Ununited', 'Humans', 'Male', 'Middle Aged'] | 12,133,360 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.406'], ['M01.060.406.448'], ['E04.555.300'], ['G16.762.891.500'], ['C26.404.468'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Characteristics of Automated Insulin Suspension and Glucose Responses with the Predictive Low-Glucose Management System. | BACKGROUND: The Predictive Low-Glucose Management (PLGM) system suspends basal insulin when hypoglycemia is predicted and reduces hypoglycemia. The aim of this analysis was to explore the characteristics of automated insulin suspension and sensor glucose (SG) responses following PLGM-initiated pump suspension.RESEARCH ... | ['Adolescent', 'Blood Glucose', 'Blood Glucose Self-Monitoring', 'Child', 'Diabetes Mellitus, Type 1', 'Female', 'Humans', 'Hypoglycemia', 'Hypoglycemic Agents', 'Insulin', 'Insulin Infusion Systems', 'Male', 'Treatment Outcome'] | 30,585,769 | [['M01.060.057'], ['D09.947.875.359.448.500'], ['E01.370.225.124.100.105', 'E01.370.374.100', 'E01.370.520.100', 'E02.900.950.500', 'E05.200.124.100.105'], ['M01.060.406'], ['C18.452.394.750.124', 'C19.246.267', 'C20.111.327'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C18.452.394.984'], ['D27.505.696.422'], [... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Escherichia coli plasmid vectors for high-level regulated expression of the bacteriophage lambda xis gene product. | The bacteriophage lambda Xis protein is one of the proteins required for site-specific excisive recombination by which the lambda prophage is excised from the Escherichia coli bacterial chromosome. We cloned the lambda xis gene under the control of several prokaryotic promoters to obtain a sufficient source of the prot... | ['Bacteriophage lambda', 'Base Sequence', 'Cloning, Molecular', 'DNA, Bacterial', 'Escherichia coli', 'Gene Expression Regulation', 'Plasmids', 'Protein Biosynthesis', 'Recombination, Genetic'] | 6,229,452 | [['B04.123.150.800.230', 'B04.123.205.230', 'B04.280.090.800.230'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.393.220'], ['D13.444.308.212'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['G05.308'], ['G05.360.600'], ['G02.111.660.871', 'G03.734.871', 'G05.297.670'], ['G05.728']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
IgG antibodies mediate protective immunity of inactivated vaccine for highly pathogenic H5N1 influenza viruses in ferrets. | Outbreaks of highly pathogenic H5N1 influenza viruses have been reported in many countries worldwide. The possibility of pandemics caused by H5N1 influenza viruses is high since human infections by H5N1 viruses continually occur. In this study we determined the immune response and efficacy of inactivated H5N1 vaccine d... | ['Animal Structures', 'Animals', 'Antibodies, Viral', 'Bodily Secretions', 'Ferrets', 'Immunization, Secondary', 'Immunoglobulin G', 'Influenza A Virus, H5N1 Subtype', 'Influenza Vaccines', 'Injections, Intramuscular', 'Orthomyxoviridae Infections', 'Survival Analysis', 'Vaccination', 'Vaccines, Inactivated'] | 20,565,295 | [['A13'], ['B01.050'], ['D12.776.124.486.485.114.254', 'D12.776.124.790.651.114.254', 'D12.776.377.715.548.114.254'], ['A12.200'], ['B01.050.150.900.649.313.750.250.575.350'], ['E02.095.465.425.400.485', 'E05.478.550.550'], ['D12.776.124.486.485.114.619.393', 'D12.776.124.790.651.114.619.393', 'D12.776.377.715.548.114.... | ['Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[Cytokines with effects on myelopoiesis. On mice, molecular biology and men]. | The proliferation and differentiation of hematopoietic progenitors to mature blood cells are regulated by a family of glycoprotein cytokines with paracrine functions. Here in, the biology, possible pathogenic functions, and pharmacological potential of cytokines stimulating myelopoiesis are briefly reviewed. | ['Animals', 'Biological Factors', 'Cytokines', 'Glycoproteins', 'Hematopoiesis', 'Humans', 'Mice', 'Neoplasms', 'Neoplasms, Experimental'] | 2,665,177 | [['B01.050'], ['D23'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['D09.400.430', 'D12.776.395'], ['G04.152.825', 'G09.188.343'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649.313.992.635.505.500'], ['C04'], ['C04.619', 'E05.598.500.496']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Comparison of changes in the hypoglossal and the phrenic nerve activity in response to increasing depth of anesthesia in cats. | The effects of increasing depths of anesthesia on the activities of the hypoglossal nerve (HN) and the phrenic nerve (PN) were investigated in artificially ventilated, vagotomized cats. An abrupt increase in inspired concentration of halothane from 1% to 4% immediately decreased both HN and PN activities, but HN activi... | ['Anesthesia, Inhalation', 'Animals', 'Cats', 'Depression, Chemical', 'Diaphragm', 'Diazepam', 'Halothane', 'Hypoglossal Nerve', 'Ketamine', 'Phrenic Nerve', 'Thiopental', 'Tongue', 'Vagotomy', 'Vagus Nerve'] | 6,691,591 | [['E03.155.197.197'], ['B01.050'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['G07.690.773.750'], ['A02.633.567.900.300'], ['D03.633.100.079.080.070.216'], ['D02.455.526.340'], ['A08.800.800.120.330'], ['D02.455.426.392.368.367.652'], ['A08.800.800.720.150.700'], ['D03.383.742.698.253.800.810'], ['A03.556.500.88... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Considerations for conducting qualitative research with pediatric patients for the purpose of PRO development. | PURPOSE: To provide an overview of methodological considerations when conducting qualitative research with pediatric patients for the purpose of patient-reported outcome measure developmentMETHODS: A literature review of qualitative methods in pediatric measure development was completed. Eight clinicians providing care... | ['Child', 'Child, Preschool', 'Communication', 'Female', 'Humans', 'Interviews as Topic', 'Male', 'Patient Reported Outcome Measures', 'Pediatrics', 'Qualitative Research', 'Quality of Life', 'Research Design'] | 26,941,216 | [['M01.060.406'], ['M01.060.406.448'], ['F01.145.209', 'L01.143'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.420', 'L01.399.250.520', 'N05.715.360.300.400', 'N06.850.520.308.420'], ['E05.318.308.980.344.500', 'N03.349.380.210.750', 'N04.761.559.590.399.875', 'N05.425.210.500', 'N05.715.360.300.800.... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 |
Retnla overexpression attenuates allergic inflammation of the airway. | Resistin-like molecule alpha (Retnla), also known as 'Found in inflammatory zone 1', is a secreted protein that has been found in bronchoalveolar lavage (BAL) fluid of ovalbumin (OVA)-induced asthmatic mice and plays a role as a regulator of T helper (Th)2-driven inflammation. However, the role of Retnla in the progres... | ['Animals', 'Asthma', 'Base Sequence', 'Bronchoalveolar Lavage Fluid', 'DNA Primers', 'Enzyme-Linked Immunosorbent Assay', 'Hypersensitivity', 'Intercellular Signaling Peptides and Proteins', 'Mice', 'Mice, Inbred C57BL', 'Mice, Transgenic', 'Real-Time Polymerase Chain Reaction'] | 25,415,454 | [['B01.050'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.927.100.500'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170',... | ['Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Pulmonary toxicity associated with pomalidomide. | Pomalidomide, previously used to treat multiple myeloma, has been reported to cause acute pulmonary toxicity that improves with drug discontinuation. We present a case of delayed pneumonitis with persistent fibrosis associated with pomalidomide. A 61-year-old male treated with pomalidomide and corticosteroids presented... | ['Antineoplastic Agents', 'Humans', 'Lung', 'Male', 'Middle Aged', 'Multiple Myeloma', 'Pneumonia', 'Pulmonary Fibrosis', 'Thalidomide', 'Tomography, X-Ray Computed'] | 30,355,421 | [['D27.505.954.248'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A04.411'], ['M01.060.116.630'], ['C04.557.595.500', 'C14.907.454.460', 'C15.378.147.780.650', 'C15.378.463.515.460', 'C20.683.515.845', 'C20.683.780.650'], ['C01.748.610', 'C08.381.677', 'C08.730.610'], ['C08.381.765'], ['D02.241.223.805.810.800',... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Experimental determination of coefficient of evaporative heat loss in still air (author's transl)]. | The authors have determined the coefficient of evaporative heat loss of the human body (he) by means of humidity steps in low air movement (Va less than or equal to 0,2 m/s). Such a determination requires a fully wetted skin and this implies therefore some loss of dripping sweat. The collection of this dripping sweat a... | ['Adult', 'Body Temperature Regulation', 'Humans', 'Humidity', 'Skin Temperature', 'Sweating', 'Temperature'] | 1,193,094 | [['M01.060.116'], ['G07.110.232', 'G07.410.421', 'G16.012.500.535'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G16.500.275.063.725.310', 'G16.500.750.775.310', 'N06.230.150.372', 'N06.230.300.100.725.310'], ['G07.110.753', 'G13.750.844'], ['G07.110.232.693', 'G07.410.421.693', 'G13.750.860', 'G16.012.500.535.6... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Embolisation of the external carotid artery in the treatment of carotid cavernous sinus fistulae. | A review of treatment methods used to control carotid cavernous sinus fistulae is presented. Three cases are described in which embolisation of the external carotid artery was done along with intracranial vascular procedures in the management of carotid cavernous fistulae. | ['Adolescent', 'Adult', 'Arteriovenous Fistula', 'Carotid Artery Diseases', 'Carotid Artery, External', 'Cavernous Sinus', 'Embolization, Therapeutic', 'Gelatin Sponge, Absorbable', 'Humans', 'Male', 'Middle Aged'] | 421,416 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Uridine adenosine tetraphosphate acts as a proangiogenic factor in vitro through purinergic P2Y receptors. | Uridine adenosine tetraphosphate (Up4A), a dinucleotide, exerts vascular influence via purinergic receptors (PR). We investigated the effects of Up4A on angiogenesis and the putative PR involved. Tubule formation assay was performed in a three-dimensional system, in which human endothelial cells were cocultured with pe... | ['Angiogenesis Inducing Agents', 'Angiopoietin-1', 'Cells, Cultured', 'Coculture Techniques', 'Dinucleoside Phosphates', 'Dose-Response Relationship, Drug', 'Human Umbilical Vein Endothelial Cells', 'Humans', 'Neovascularization, Physiologic', 'Pericytes', 'Purinergic P2Y Receptor Agonists', 'Purinergic P2Y Receptor An... | 27,233,766 | [['D27.505.696.377.077.077'], ['D12.644.276.100.100.100', 'D12.776.467.100.100.100', 'D23.529.100.100.100'], ['A11.251'], ['E05.481.500.374'], ['D13.695.250'], ['G07.690.773.875', 'G07.690.936.500'], ['A11.436.275.682'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G09.330.630'], ['A07.015.700.750', 'A10.272.491.... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Urinary albumin excretion in non-insulin-dependent diabetic patients. Effects of an angiotensin-converting enzyme inhibitor]. | BACKGROUND: Microalbuminuria in diabetic patients is diagnostic of early renal involvement and angiotensin converting enzyme inhibitors reduce albumin excretion in these subjects.AIM: To assess the effects of an angiotensin converting enzyme inhibitor on urinary albumin excretion in non insulin dependent diabetic patie... | ['Adult', 'Aged', 'Albumins', 'Albuminuria', 'Angiotensin-Converting Enzyme Inhibitors', 'Diabetes Mellitus, Type 2', 'Double-Blind Method', 'Enalapril', 'Follow-Up Studies', 'Humans', 'Middle Aged'] | 9,197,016 | [['M01.060.116'], ['M01.060.116.100'], ['D12.776.034'], ['C12.777.934.734.269', 'C13.351.968.934.734.269', 'C23.888.942.750.269'], ['D27.505.519.389.745.085'], ['C18.452.394.750.149', 'C19.246.300'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['D12.644.456.345.360'], ['E05.318... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Morphological and ultrastructural analysis of normal, injured and osteoarthritic human knee menisci. | The human meniscus plays a crucial role for transmission and distribution of load across the knee, as well as shock absorption, joint stability, lubrication, and congruity. The aim of this study was to compare the complex geometry, and unique ultrastructure and tissue composition of the meniscus in healthy (control) an... | ['Adult', 'Aged', 'Calcinosis', 'Extracellular Matrix', 'Female', 'Humans', 'Knee Injuries', 'Knee Joint', 'Male', 'Meniscus', 'Microscopy, Electron, Transmission', 'Middle Aged', 'Osteoarthritis, Knee'] | 30,739,432 | [['M01.060.116'], ['M01.060.116.100'], ['C18.452.174.130'], ['A11.284.295.310'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C26.558.554'], ['A02.835.583.475'], ['A02.165.308.538', 'A10.165.382.350.163'], ['E01.370.350.515.402.580', 'E05.595.402.580'], ['M01.060.116.630'], ['C05.550.114.606.500', 'C05.799.613.50... | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Tumor necrosis factor-alpha inhibition of 17 alpha-hydroxylase/C17-20 lyase gene (Cyp17) expression. | Testosterone biosynthesis in Leydig cells is dependent on the action of 17 alpha-hydroxylase/C17-20 lyase cytochrome P450 (P450c17), which is encoded by the Cyp17 gene. Tumor necrosis factor-alpha (TNF alpha), a proinflammatory cytokine, inhibits cAMP-stimulated testosterone production in mouse Leydig cells. The inhibi... | ['Aldehyde-Lyases', 'Animals', 'Biological Transport', 'Cells, Cultured', 'Cyclic AMP', 'Cytochrome P-450 Enzyme Inhibitors', 'Cytochrome P-450 Enzyme System', 'Gene Expression', 'Leydig Cells', 'Male', 'Mice', 'Mice, Inbred Strains', 'Naphthalenes', 'Protein Kinase C', 'RNA, Messenger', 'Steroid 17-alpha-Hydroxylase',... | 7,628,389 | [['D08.811.520.224.062'], ['B01.050'], ['G03.143'], ['A11.251'], ['D03.633.100.759.646.138.395', 'D13.695.462.200', 'D13.695.667.138.395', 'D13.695.827.068.395'], ['D27.505.389.500', 'D27.505.519.389.335'], ['D08.244.453', 'D08.811.682.690.708.170', 'D12.776.422.220.453'], ['G05.297'], ['A05.360.444.849.513', 'A06.300.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Long-term outlook for renal transplant recipients with one-year function. "Doctor, what are my chances"? | Patients with renal transplants that survive the first year often ask about the chance of long-term function. We studied 1850 patients with primary transplants from June 7, 1963 to September 1, 1988 who had graft survival of greater than 1 year. Patients were grouped by donor type, diabetic status, and whether or not t... | ['Cyclosporins', 'Graft Survival', 'Humans', 'Kidney Transplantation', 'Survival Rate', 'Time Factors'] | 1,987,680 | [['D04.345.566.235', 'D12.644.641.235'], ['G12.875.545.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.870.500', 'E04.936.450.485', 'E04.950.774.400'], ['E05.318.308.985.550.900', 'N01.224.935.698.826', 'N06.850.505.400.975.550.900', 'N06.850.520.308.985.550.900'], ['G01.910.857']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Coinfection with Mycobacterium tuberculosis and Pneumocystis Jirovecii in immunocompetent young woman. | Pneumocystis pneumonia is a severe opportunistic infection in immunocompromised patients, caused by Pneumocystis jirovecii (P. jirovecii). The co-infection with community-acquired P. jirovecii and Mycobacterium tuberculosis (M. tuberculosis) is exceptionally described in non immunocompromised patients. We herein report... | ['Coinfection', 'Female', 'Humans', 'Immunocompetence', 'Pneumocystis carinii', 'Pneumonia, Pneumocystis', 'Tuberculosis', 'Young Adult'] | 26,012,211 | [['C01.218'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G12.460'], ['B01.300.107.730.650'], ['C01.150.703.534.700', 'C01.150.703.770.700', 'C01.748.435.700', 'C01.748.610.675', 'C08.381.472.700', 'C08.381.677.675', 'C08.730.435.700', 'C08.730.610.675'], ['C01.150.252.410.040.552.846'], ['M01.060.116.815']] | ['Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Structural Rearrangements Maintain the Glycan Shield of an HIV-1 Envelope Trimer After the Loss of a Glycan. | The HIV-1 envelope (Env) glycoprotein is the primary target of the humoral immune response and a critical vaccine candidate. However, Env is densely glycosylated and thereby substantially protected from neutralisation. Importantly, glycan N301 shields V3 loop and CD4 binding site epitopes from neutralising antibodies. ... | ['Antibodies, Monoclonal', 'Binding Sites', 'CD4 Antigens', 'Epitopes', 'Glycosylation', 'HIV Antibodies', 'HIV Envelope Protein gp120', 'HIV Infections', 'HIV Seropositivity', 'HIV-1', 'Humans', 'Immunity, Humoral', 'Polysaccharides', 'Protein Conformation'] | 30,302,011 | [['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['G02.111.570.120'], ['D12.776.543.750.705.852.420.810.500', 'D12.776.543.750.830.700.025', 'D23.050.301.264.894.100', 'D23.101.100.894.100'], ['D23.050.550'], ['G02.111.158.812', 'G02.607.299', 'G03.191.812'], ['D12.776.124... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Expression of the TMPRSS2:ERG fusion gene predicts cancer recurrence after surgery for localised prostate cancer. | The prostate-specific gene, TMPRSS2 is fused with the gene for the transcription factor ERG in a large proportion of human prostate cancers. The prognostic significance of the presence of the TMPRSS2:ERG gene fusion product remains controversial. We examined prostate cancer specimens from 165 patients who underwent sur... | ['Adult', 'Aged', 'Biomarkers, Tumor', 'Humans', 'Male', 'Middle Aged', 'Neoplasm Recurrence, Local', 'Oncogene Proteins, Fusion', 'Prognosis', 'Prostate-Specific Antigen', 'Prostatic Neoplasms'] | 17,971,772 | [['M01.060.116'], ['M01.060.116.100'], ['D23.101.140'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C04.697.655', 'C23.550.727.655'], ['D12.776.602.500.500', 'D12.776.624.664.500'], ['E01.789'], ['D08.811.277.656.300.760.442.750', 'D08.811.277.656.959.350.442.750', 'D12.776.866.249.500', 'D2... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Inflammatory biomarkers to predict adverse outcomes in postoperative patients with acute type A aortic dissection. | Objectives. The present study aimed to evaluate prognostic value of inflammatory markers for in-hospital mortality and renal complication in patients undergoing surgery for acute type A aortic dissection (ATAAD). Design. Serum concentration of C-reactive protein, leukocyte counts, procalcitonin (PCT), tumor necrosis fa... | ['Acute Disease', 'Aged', 'Aneurysm, Dissecting', 'Aortic Aneurysm', 'Biomarkers', 'Cytokines', 'Early Diagnosis', 'Female', 'Humans', 'Inflammation Mediators', 'Male', 'Middle Aged', 'Predictive Value of Tests', 'Procalcitonin', 'Reproducibility of Results', 'Retrospective Studies', 'Risk Factors', 'Time Factors', 'Tr... | 31,738,077 | [['C23.550.291.125'], ['M01.060.116.100'], ['C14.907.055.050'], ['C14.907.055.239', 'C14.907.109.139'], ['D23.101'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['E01.390'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D23.469'], ['M01.060.116.630'], ['E05.318.370.800.650', 'N05.715.360.325.700.640', '... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.