Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Effects of varicocele on serum testosterone and changes of testosterone after varicocelectomy: a prospective controlled study. | OBJECTIVE: To examine the hypotheses that clinical varicoceles affect baseline serum total testosterone levels (T) and varicocelectomy improves T.MATERIALS AND METHODS: This prospective, nonrandomized, controlled study involved 4 groups of adult men. Varicocele-infertile treatment group (VIT) included 66 men who underw... | ['Adult', 'Case-Control Studies', 'Humans', 'Infertility, Male', 'Male', 'Middle Aged', 'Prospective Studies', 'Sperm Count', 'Testosterone', 'Treatment Outcome', 'Urogenital Surgical Procedures', 'Varicocele', 'Vascular Surgical Procedures', 'Young Adult'] | 25,214,202 | [['M01.060.116'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.294.365.700'], ['M01.060.116.630'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['E01.370.225.500.195.870', 'E01.370.225.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Back school for patients with vertebral fractures. | Back school is behavior training for the prevention and treatment of back problems arising from faulty body posture and muscular dysfunction. This paper describes the conception and evaluation of a back school program for patients with vertebral fractures. The curriculum includes the provision of detailed information a... | ['Adolescent', 'Adult', 'Aged', 'Child', 'Counseling', 'Curriculum', 'Educational Measurement', 'Female', 'Humans', 'Male', 'Middle Aged', 'Patient Education as Topic', 'Physical Therapy Modalities', 'Posture', 'Relaxation Therapy', 'Schools', 'Spinal Fractures'] | 1,747,306 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.406'], ['F02.784.176', 'F04.408.413', 'N02.421.143.303', 'N02.421.461.363'], ['I02.158'], ['I02.399'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['I02.233.332.500', 'N02.421.726.407.680'], ['E02.779', 'E02.831.535'], ['G11.427... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 |
In-vitro resistance to zidovudine and alpha-interferon in HIV-1 isolates from patients: correlations with treatment duration and response. | OBJECTIVE: To measure in-vitro antiviral drug susceptibilities of human immunodeficiency virus type 1 (HIV-1) isolates recovered from patients treated with alpha-interferon or zidovudine and patients not treated with these drugs and to examine the relation of these susceptibility measurements to duration of therapy, di... | ['Acquired Immunodeficiency Syndrome', 'Drug Resistance, Microbial', 'HIV Infections', 'HIV-1', 'Humans', 'Interferon-alpha', 'Leukocytes, Mononuclear', 'Zidovudine'] | 1,503,348 | [['C01.221.250.875.040', 'C01.221.812.640.400.040', 'C01.778.640.400.040', 'C01.925.782.815.616.400.040', 'C01.925.813.400.040', 'C01.925.839.040', 'C20.673.480.040'], ['G06.225', 'G07.690.773.984.269'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Hepatic cell dysplasia. A pre-malignant lesion related to hepatocellular carcinoma and infection by hepatitis B virus]. | This paper reports the study of liver cell dysplasia in cases of hepatic cirrhosis, cirrhosis associated to hepatocellular carcinoma and hepatocellular carcinoma without cirrhosis. The frequency of the lesion was higher in cases of hepatic cirrhosis and hepatocellular carcinoma associated (84.2%), compared to the other... | ['Carcinoma, Hepatocellular', 'Cell Transformation, Neoplastic', 'Hepatitis B', 'Humans', 'Liver', 'Liver Neoplasms', 'Precancerous Conditions'] | 2,849,924 | [['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['C04.697.098.500', 'C23.550.727.098.500'], ['C01.221.250.500', 'C01.925.256.430.400', 'C01.925.440.435', 'C06.552.380.705.437'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A03.620'], ['C04.588.274.623', 'C06.301.623', 'C... | ['Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Copper activates metallothionein gene transcription by altering the conformation of a specific DNA binding protein. | Copper homeostasis in yeast involves a copper binding protein, metallothionein, and a trans-acting regulatory protein that activates transcription of the metallothionein gene in response to copper ions. We show that the regulatory protein specifically binds to the metallothionein gene control sequences in the presence,... | ['Base Sequence', 'Copper', 'DNA-Binding Proteins', 'Gene Expression Regulation', 'Metallothionein', 'Molecular Sequence Data', 'Molecular Structure', 'Protein Conformation', 'Saccharomyces cerevisiae', 'Transcription, Genetic'] | 3,052,856 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D01.268.556.195', 'D01.268.956.170', 'D01.552.544.195'], ['D12.776.260'], ['G05.308'], ['D12.776.556.670'], ['L01.453.245.667'], ['G02.111.570', 'G02.466'], ['G02.111.570.820.709'], ['B01.300.107.795.785.800', 'B01.300.930.705.655'], ['G02.111.873', 'G05.297... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Extensive genome heterogeneity leads to preferential allele expression and copy number-dependent expression in cultivated potato. | Relative to homozygous diploids, the presence of multiple homologs or homeologs in polyploids affords greater tolerance to mutations that can impact genome evolution. In this study, we describe sequence and structural variation in the genomes of six accessions of cultivated potato (Solanum tuberosum L.), a vegetatively... | ['Alleles', 'DNA Copy Number Variations', 'Diploidy', 'Metabolic Networks and Pathways', 'Plant Leaves', 'Plant Tubers', 'Polymorphism, Single Nucleotide', 'Solanum tuberosum', 'Tetraploidy'] | 28,869,794 | [['G05.360.340.024.340.030'], ['G05.365.795.297.500'], ['G05.700.264'], ['G03.493'], ['A18.024.812'], ['A18.400.625'], ['G05.365.795.598'], ['B01.650.940.800.575.912.250.908.500.725.777'], ['C23.550.210.702.249', 'G05.365.590.175.677.249', 'G05.700.740.249']] | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Antibodies against crystals. | We suggest that crystals, when introduced into an organism, may behave as conventional antigens, mediating the production of specific antibodies. These antibodies would bear an imprint of the crystal surface and may consequently behave as a nucleating matrix in a new crystallization event. Thus, they would behave as ca... | ['Allopurinol', 'Animals', 'Antibody Formation', 'Arthritis, Rheumatoid', 'Crystallography', 'Electrophoresis, Polyacrylamide Gel', 'Enzyme-Linked Immunosorbent Assay', 'Gout', 'Humans', 'Immunoglobulin G', 'Osteoarthritis', 'Rabbits', 'Synovial Fluid', 'Uric Acid'] | 1,592,211 | [['D03.633.100.759.160'], ['B01.050'], ['G12.450.050.370.250'], ['C05.550.114.154', 'C05.799.114', 'C17.300.775.099', 'C20.111.199'], ['E05.196.309', 'H01.181.529.240'], ['E05.196.401.402', 'E05.301.300.319'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Health inequities in the diagnosis and outcome of sepsis in Argentina: a prospective cohort study. | BACKGROUND: Socioeconomic variables impact health outcomes but have rarely been evaluated in critical illness. Low- and middle-income countries bear the highest burden of sepsis and also have significant health inequities. In Argentina, public hospitals serve the poorest segment of the population, while private institu... | ['APACHE', 'Adult', 'Aged', 'Aged, 80 and over', 'Argentina', 'Cohort Studies', 'Female', 'Health Status Disparities', 'Hospital Mortality', 'Humans', 'Intensive Care Units', 'Male', 'Middle Aged', 'Outcome Assessment, Health Care', 'Prospective Studies', 'Sepsis', 'Social Class'] | 31,288,865 | [['E05.318.308.980.438.475.365', 'E05.318.308.980.438.475.456.500.250', 'N05.715.360.300.800.438.375.364.500.250', 'N06.850.520.308.980.438.475.364.500.250'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['Z01.107.757.077'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750']... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Named Groups [M]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Effects of bicarbonate on lithium transport in human red cells. | Lithium influx into human erythrocytes increased 12-fold, when chloride was replaced with bicarbonate in a 150 mM lithium medium (38 degrees C. pH 7.4). The increase was linearly related to both lithium- and bicarbonate concentration, and was completely eliminated by the amino reagent 4, 4'- diisothiocyanostilbene-2,2'... | ['Bicarbonates', 'Cell Membrane Permeability', 'Chlorides', 'Dose-Response Relationship, Drug', 'Erythrocytes', 'Humans', 'Lithium', 'Sodium'] | 670,928 | [['D01.200.275.150.100', 'D01.248.497.158.165.100'], ['G03.143.335', 'G04.175'], ['D01.210.450.150', 'D01.248.497.158.215'], ['G07.690.773.875', 'G07.690.936.500'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.268.549.450', 'D01.268.557.290', 'D01.552.528.480... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Bilateral occlusion of retinal vessels in Waldenstrom's disease (a case study)]. | The article describes a clinical case of bilateral occlusion of retinal vessels in a patient with Waldenstrom's disease - a rare lymphoplasmocytic tumor of the bone marrow characterized by a complex of syndromes, among which the syndrome of blood hyperviscosity dominates. Comprehensive clinical, instrumental and labora... | ['Choroid', 'Hemodynamics', 'Humans', 'Retina', 'Retinal Vessels', 'Waldenstrom Macroglobulinemia'] | 32,241,974 | [['A09.371.894.223'], ['G09.330.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A09.371.729'], ['A07.015.611'], ['C04.557.595.925', 'C14.907.454.960', 'C15.378.147.780.925', 'C15.378.463.515.960', 'C15.604.515.925', 'C20.683.780.925']] | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Treatment of endometrial hyperplasia with Goserelin depot, an LH-RH analog]. | Nineteen patients with simple endometrial hyperplasia presenting metrorrhagia or menometrorrhagia were treated with 4 injections of Goserelin depot, one every 4 weeks. 12/19 patients were refractory after previous medical therapy. The treatment with Goserelin depot resulted in a complete remission of the symptoms, occu... | ['Biopsy', 'Delayed-Action Preparations', 'Endometrial Hyperplasia', 'Endometrium', 'Female', 'Goserelin', 'Humans', 'Menorrhagia', 'Metrorrhagia'] | 8,351,064 | [['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['D26.255.210', 'E02.319.300.253'], ['C13.351.500.852.228'], ['A05.360.319.679.490'], ['D06.472.699.327.740.320.340', 'D12.644.400.400.740.320.340', 'D12.644.456.460.315', 'D12... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Phagocytic activity of peripheral blood leukocytes during acute myocardial infarction]. | INTRODUCTION: Coronary occlusion may cause acute myocardial infarction associated with many cellular and humoral disturbances of the immune system. The aim of this investigation was to examine phagocytic activity of peripherial blood monocytes and neutrophils as potential cellular markers of systemic immunological even... | ['Adult', 'Aged', 'Female', 'Humans', 'Leukocytes, Mononuclear', 'Male', 'Middle Aged', 'Myocardial Infarction', 'Neutrophils', 'Phagocytosis'] | 15,510,922 | [['M01.060.116'], ['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.118.637.555', 'A15.145.229.637.555', 'A15.382.490.555'], ['M01.060.116.630'], ['C14.280.647.500', 'C14.907.585.500', 'C23.550.513.355.750', 'C23.550.717.489.750'], ['A11.118.637.415.583', 'A11.627.340.583', 'A11.733.689', 'A15... | ['Named Groups [M]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Real-time MRI guided atrial septal puncture and balloon septostomy in swine. | Cardiac perforation during atrial septal puncture (ASP) might be avoided by improved image guidance. X-ray fluoroscopy (XRF), which guides ASP, visualizes tissue poorly and does not convey depth information. Ultrasound is limited by device shadows and constrained imaging windows. Alternatively, real-time MRI (rtMRI) pr... | ['Angioplasty, Balloon, Coronary', 'Animals', 'Cardiac Catheterization', 'Heart Atria', 'Heart Septum', 'Magnetic Resonance Imaging', 'Punctures', 'Surgery, Computer-Assisted', 'Swine'] | 16,532,499 | [['E02.148.050.060.100', 'E04.100.376.719.100', 'E04.100.814.529.124.060.100', 'E04.100.814.529.968.050', 'E04.502.382.124.060.100', 'E04.502.382.968.050', 'E04.928.220.520.100', 'E05.157.016.060.100'], ['B01.050'], ['E01.370.370.380.140', 'E02.148.442', 'E05.157.250'], ['A07.541.358'], ['A07.541.459'], ['E01.370.350.8... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Modulation of somatosensory evoked potentials using transcranial magnetic intermittent theta burst stimulation. | OBJECTIVE: To study the modulation of somatosensory evoked potentials (SEP) using transcranial magnetic intermittent theta burst stimulation (iTBS) over human primary motor (M1) and sensory (S1) cortices.METHODS: Eleven healthy subjects participated in the study. Median nerve SEP were elicited by electrical stimulation... | ['Adult', 'Analysis of Variance', 'Electric Stimulation', 'Electroencephalography', 'Evoked Potentials, Somatosensory', 'Female', 'Humans', 'Male', 'Median Nerve', 'Motor Cortex', 'Reaction Time', 'Somatosensory Cortex', 'Time Factors', 'Transcranial Magnetic Stimulation'] | 17,892,970 | [['M01.060.116'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['E05.723.402'], ['E01.370.376.300', 'E01.370.405.245'], ['G07.265.216.500.400', 'G11.561.200.500.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A08.800.800.720.050.500'], ['A08.186.211.200.885.287.500.270.548', 'A08.186.211... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
New Deletion at Promoter of HBG1 Gene in Sickle Cell Disease Patients With High HbF Level. | OBJECTIVES: The 5' upstream region of the HBG1 gene plays a very important role in the expression of fetal hemoglobin (HbF). In contrast, increased HbF levels can inhibit the deoxygenation-induced polymerization of sickle hemoglobin (á2âS2), which leads to moderation at the clinical level among sickle cell disease (SCD... | ['Anemia, Sickle Cell', 'Base Sequence', 'Female', 'Fetal Hemoglobin', 'Humans', 'Male', 'Response Elements', 'Retrospective Studies', 'Sequence Deletion'] | 31,688,634 | [['C15.378.071.141.150.150', 'C15.378.420.155', 'C16.320.070.150', 'C16.320.365.155'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D12.776.124.400.303', 'D12.776.422.316.762.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.111.570.080.689.330.700', 'G02.111.570.080.689.675.700', 'G05.360.0... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
The steroidogenic and morphological effects of paclitaxel on cultured ovarian cancer cells. | We have studied the biochemical effects of paclitaxel (trade name Taxol) in three ovarian cancer (OV Ca) cell lines and JEG-3 choriocarcinoma cells. Paclitaxel (1 microgram/ml) was cytotoxic to approximately 80% of OV Ca cells, and the ED50 ranged from 6 to 9 ng/ml. Paclitaxel was also cytotoxic to JEG-3 cells (ED50 40... | ['Adenocarcinoma', 'Adenocarcinoma, Papillary', 'Aged', 'Antineoplastic Agents, Phytogenic', 'Aromatase', 'Colchicine', 'Estradiol', 'Female', 'Humans', 'Middle Aged', 'Ovarian Neoplasms', 'Paclitaxel', 'Tumor Cells, Cultured'] | 8,555,648 | [['C04.557.470.200.025'], ['C04.557.470.200.025.085'], ['M01.060.116.100'], ['D27.505.954.248.179'], ['D08.244.453.489.500', 'D08.244.453.915.099', 'D08.811.682.690.708.170.447.500', 'D08.811.682.690.708.170.915.099', 'D12.776.422.220.453.489.500', 'D12.776.422.220.453.915.099'], ['D03.132.225'], ['D04.210.500.365.415.... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Sensitivity of single contrast barium enema with regard to colorectal disease as diagnosed by colonoscopy. | The results of single contrast barium enema were retrospectively correlated with colonoscopically diagnosed colorectal disease in 54 patients (75 lesions). Altogether 66 lesions (88%) were correctly diagnosed. The sensitivity of barium enema for polyps was 81% (26/32). There were three perceptive errors and three polyp... | ['Barium Sulfate', 'Colonic Diseases', 'Colonoscopy', 'Enema', 'Humans', 'Radiography', 'Rectal Diseases'] | 7,151,815 | [['D01.103.075', 'D01.875.800.800.850.075'], ['C06.405.469.158'], ['E01.370.372.250.250.200', 'E01.370.388.250.250.250.160', 'E04.210.240.250.160', 'E04.502.250.250.250.160'], ['E02.319.347'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.700'], ['C06.405.469.860']] | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
AgrAbility mental/behavioral health for farm/ranch families with disabilities. | Farmers and their families are at high risk for work-related stressors and incidents that may result in physically disabling conditions. Coping with the acute and chronic results of disability has been documented to contribute to mental and behavioral health issues. Improvements in the ability to cope with the impact o... | ['Agriculture', 'Community Health Services', 'Counseling', 'Disabled Persons', 'Health Promotion', 'Health Surveys', 'Humans', 'Interinstitutional Relations', 'Mental Disorders', 'Rural Health Services', 'United States', 'United States Department of Agriculture'] | 21,462,021 | [['J01.040'], ['N02.421.143'], ['F02.784.176', 'F04.408.413', 'N02.421.143.303', 'N02.421.461.363'], ['M01.150'], ['I02.233.332.445', 'N02.421.726.407.579'], ['E05.318.308.980.438', 'N05.715.360.300.800.438', 'N06.850.520.308.980.438'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N04.452.822.400'], ['F03'], ['N0... | ['Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
IL10 family member genes IL19 and IL20 are associated with recurrent wheeze after respiratory syncytial virus bronchiolitis. | Mechanisms underlying the increased risk of recurrent wheeze after respiratory syncytial virus lower respiratory tract infection (RSV LRTI) are unclear. Specifically, information about genetic determinants of recurrent wheeze after RSV LRTI is limited. We performed a candidate gene association study to identify genetic... | ['Adaptive Immunity', 'Bronchiolitis, Viral', 'Genetic Association Studies', 'Genetic Variation', 'Genotype', 'Haplotypes', 'Humans', 'Interleukins', 'Logistic Models', 'Polymorphism, Single Nucleotide', 'Respiratory Sounds', 'Respiratory Syncytial Virus Infections', 'Respiratory Syncytial Virus, Human'] | 21,814,157 | [['G12.450.050'], ['C01.748.099.135.321', 'C01.925.109', 'C08.127.446.135.321', 'C08.381.495.146.135.321', 'C08.730.099.135.321'], ['E05.393.385'], ['G05.365'], ['G05.380'], ['G05.380.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.465', 'D12.776.467.374.465', 'D23.529.374.465'], ['E05.318.740... | ['Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
From personal to global: Understandings of social accountability from stakeholders at four medical schools. | AIM: This paper addresses the question of how social accountability is conceptualised by staff, students and community members associated with four medical schools aspiring to be socially accountable in two countries.METHODS: Using a multiple case study approach this research explored how contextual issues have influen... | ['Attitude of Health Personnel', 'Australia', 'Community Participation', 'Education, Medical', 'Faculty', 'Health Personnel', 'Humans', 'Interviews as Topic', 'Organizational Case Studies', 'Philippines', 'Public Health', 'Schools, Medical', 'Social Responsibility', 'Students, Medical'] | 26,751,185 | [['F01.100.050', 'N05.300.100'], ['Z01.639.100', 'Z01.678.100.373'], ['N02.421.143.212', 'N03.540.245.360'], ['I02.358.399'], ['M01.526.702.250'], ['M01.526.485', 'N02.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.420', 'L01.399.250.520', 'N05.715.360.300.400', 'N06.850.520.308.420'], ['N03.349.... | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Disciplines and Occupations [H]', 'Humanities... | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
Low molecular weight heparin once daily compared with conventional low-dose heparin twice daily. A prospective double-blind multicentre trial on prevention of postoperative thrombosis. | In a randomized, prospective, double-blind multicentre trial, the effect of conventional low-dose heparin 5000 units twice daily, was compared with that of a low molecular weight heparin fragment (4000-5000) 5000 anti-factor Xa units once daily. Four hundred and thirty-two patients fulfilled the inclusion criteria and ... | ['Adult', 'Aged', 'Clinical Trials as Topic', 'Double-Blind Method', 'Drug Administration Schedule', 'Hemorrhage', 'Heparin', 'Humans', 'Middle Aged', 'Molecular Weight', 'Postoperative Complications', 'Random Allocation', 'Thrombosis'] | 3,512,031 | [['M01.060.116'], ['M01.060.116.100'], ['E05.318.372.250.250', 'N05.715.360.330.250.250', 'N06.850.520.450.250.250'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['E02.319.283'], ['C23.550.414'], ['D09.698.373.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.11... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Comparison of oncological outcomes between laparoscopic and open procedures in non-metastazing colonic carcinomas]. | AIM: The aim of our study was to compare oncological results of laparoscopic assisted coloctomy and open colectomy in the treatment of nonmetastatic colon cancer.MATERIAL AND METHODS: In this prospective nonrandomised clinical trail a group of elective laparoscopic or open resections in patients with the colon adenocar... | ['Adenocarcinoma', 'Aged', 'Colectomy', 'Colonic Neoplasms', 'Female', 'Humans', 'Laparoscopy', 'Male', 'Neoplasm Recurrence, Local'] | 20,662,437 | [['C04.557.470.200.025'], ['M01.060.116.100'], ['E04.210.219'], ['C04.588.274.476.411.307.180', 'C06.301.371.411.307.180', 'C06.405.249.411.307.180', 'C06.405.469.158.356.180', 'C06.405.469.491.307.180'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.388.250.520', 'E04.502.250.520'], ['C04.697.655', 'C23.5... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Significant lateralisation of supratentorial ICP after blunt head trauma. | After blunt head trauma simultaneous left and right hemispheric intracranial pressure (ICP) monitoring revealed a pressure gradient of about 30 mmHg persisting until the 5th day after the accident equilibrating thereafter. ICP was elevated over the radiologically more compressed hemisphere. The supratentorial space see... | ['Brain Edema', 'Cerebral Ventricles', 'Child, Preschool', 'Dominance, Cerebral', 'Female', 'Head Injuries, Closed', 'Humans', 'Intracranial Pressure', 'Tomography, X-Ray Computed', 'Transducers, Pressure'] | 1,615,772 | [['C10.228.140.187'], ['A08.186.211.140'], ['M01.060.406.448'], ['F02.830.297', 'G11.561.225'], ['C10.900.300.350', 'C26.915.300.450', 'C26.974.382'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G11.561.170.505'], ['E01.370.350.350.810', 'E01.370.350.600.350.700.810', 'E01.370.350.700.700.810', 'E01.370.350.700.... | ['Diseases [C]', 'Anatomy [A]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Biological efficiency to weaning and to slaughter of crossbred beef cattle with different genetic potential for milk. | Biological efficiency of beef production to weaning and to slaughter was estimated in three groups of cattle reasonably similar in growth and mature size but different in the amount of milk available to the calves (low (L) = Hereford x Angus, medium (M) = Red Poll x Angus and high (H) = Milking Shorthorn x Angus). Effi... | ['Age Factors', 'Animals', 'Cattle', 'Crosses, Genetic', 'Energy Intake', 'Energy Metabolism', 'Female', 'Lactation', 'Weaning'] | 2,401,652 | [['N05.715.350.075', 'N06.850.490.250'], ['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['E05.393.281'], ['G07.203.650.240.340'], ['G03.295'], ['G08.686.523', 'G08.686.702.500'], ['G07.203.650.220.500.750', 'G07.203.650.915']] | ['Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Role of DNA-dependent RNA polymerases II and III in transcription of the adenovirus genome late in productive infection. | DNA-dependent RNA polymerases I, II, and III were isolated and partially purified from KB (human) cells 18 hr after infection with adenovirus 2. As reported previously for the enzymes from other animal cells, RNA polymerase II was completely sensitive to low concentrations of alpha-amanitin (50% inhibition at 0.02 mug/... | ['Adenoviridae', 'Basidiomycota', 'Carcinoma', 'Cell Line', 'Cell Nucleus', 'DNA, Viral', 'DNA-Directed RNA Polymerases', 'Humans', 'Molecular Weight', 'Mouth Neoplasms', 'Mycotoxins', 'Nucleic Acid Hybridization', 'Oligopeptides', 'Peptides, Cyclic', 'RNA, Messenger', 'RNA, Ribosomal', 'RNA, Viral', 'Transcription, Ge... | 4,530,313 | [['B04.280.030'], ['B01.300.179'], ['C04.557.470.200'], ['A11.251.210'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['D13.444.308.568'], ['D08.811.913.696.445.735.270'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.494'], ['C04.588.443.591', 'C07.465.530'], ['D23.946.587'], ['E05.393.661', 'G02.111.6... | ['Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mycophenolate mofetil is associated with altered expression of chronic renal transplant histology. | Mycophenolate mofetil (MMF) reduces acute rejection in controlled trials of kidney transplantation and is associated with better registry graft survival. Recent experimental studies have demonstrated additional antifibrotic properties of MMF, however, human histological data are lacking. We evaluated sequential prospec... | ['Adult', 'Cohort Studies', 'Cyclosporine', 'Enzyme Inhibitors', 'Female', 'Fibrosis', 'Graft Rejection', 'Humans', 'Immunosuppressive Agents', 'Kidney Glomerulus', 'Kidney Transplantation', 'Kidney Tubules', 'Male', 'Mycophenolic Acid', 'Retrospective Studies', 'Time Factors'] | 17,283,486 | [['M01.060.116'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['D04.345.566.235.300', 'D12.644.641.235.300'], ['D27.505.519.389'], ['C23.550.355'], ['G12.875.545.328'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.477.656'], ['A05.810.453.324.359', 'A05.810.453.736.5... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Effects of sugar additives on protein stability of recombinant human serum albumin during lyophilization and storage. | Few researches on the protein stabilization of recombinant human serum albumin (rHSA) have been done. In the present study, we assessed the impact of sugar lyoprotectants on the protein stability of lyophilized rHSA (65 KDa) in the solid state. For the assessment, rHSA was formulated with sucrose and trehalose, respect... | ['Calorimetry, Differential Scanning', 'Carbohydrates', 'Crystallization', 'Drug Stability', 'Drug Storage', 'Freeze Drying', 'Protein Structure, Secondary', 'Recombinant Proteins', 'Serum Albumin', 'Spectroscopy, Fourier Transform Infrared'] | 17,958,330 | [['E05.196.131.310', 'E05.196.370.310'], ['D09'], ['E05.196.300', 'G02.171'], ['E05.916.330'], ['E05.916.350'], ['E01.370.225.500.620.760.160.260', 'E01.370.225.750.600.760.160.260', 'E02.792.156.260', 'E05.200.500.620.760.160.260', 'E05.200.750.600.760.160.260', 'E05.760.156.260'], ['G02.111.570.820.709.600'], ['D12.7... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
HIV-induced abnormalities in myelopoiesis and their recovery following antiretroviral therapy. | HIV-1 infection is associated with hematologic abnormalities including defective myelopoiesis. Most studies of myelopoiesis during HIV-1 infection were performed using unfractionated bone marrow-derived mononuclear cells, thus resulting in significant inter-individual variability in the numbers of cultured precursors. ... | ['Adult', 'Antigens, CD34', 'Antiretroviral Therapy, Highly Active', 'Cells, Cultured', 'Culture Media', 'Female', 'Granulocytes', 'HIV Infections', 'HIV-1', 'Humans', 'Longitudinal Studies', 'Male', 'Middle Aged', 'Monocytes', 'Myeloid Progenitor Cells', 'Stem Cells'] | 20,353,391 | [['M01.060.116'], ['D23.050.301.264.035.134', 'D23.101.100.110.134'], ['E02.319.310.075'], ['A11.251'], ['D27.720.470.305', 'E07.206'], ['A11.118.637.415', 'A11.148.350', 'A11.627.340', 'A15.145.229.637.415', 'A15.378.316.340', 'A15.382.490.315'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.7... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Frequency-dependent myofilament Ca2+ desensitization in failing rat myocardium. | The positive force-frequency relation, one of the key factors modulating performance of healthy myocardium, has been attributed to an increased Ca(2+) influx per unit of time. In failing hearts, a blunted, flat or negative force-frequency relation has been found. In healthy and failing hearts frequency-dependent altera... | ['Actin Cytoskeleton', 'Animals', 'Calcium', 'Cardiac Output, Low', 'Contractile Proteins', 'Heart', 'Heart Ventricles', 'Intracellular Membranes', 'Male', 'Monocrotaline', 'Myocardial Contraction', 'Myocardium', 'Myocytes, Cardiac', 'Myosin Light Chains', 'Phosphorylation', 'Pressure', 'Protein Kinase C-alpha', 'Rats'... | 17,478,529 | [['A11.284.430.214.190.750.050'], ['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['C14.280.148', 'C23.888.192'], ['D12.776.210'], ['A07.541'], ['A07.541.560'], ['A11.284.149.450', 'A11.284.835.514'], ['D03.132.716.500', 'D03.633.100.772.500'], ['G09.330.580', 'G11.427.494.570'], ['A02.633.580', 'A0... | ['Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Continuous infusion of amphotericin B deoxycholate in the treatment of cryptococcal meningoencephalitis: analysis of safety and fungicidal activity. | We measured fungicidal activity of continuous infusion of amphotericin B deoxycholate plus 5'flucytosine using quantitative cultures of cerebrospinal fluid (CSF) obtained from lumbar punctures of human immunodeficiency virus (HIV)-infected patients with neurocryptococcosis during 14 days of treatment. Glomerular renal ... | ['Adult', 'Amphotericin B', 'Antifungal Agents', 'Cerebrospinal Fluid', 'Colony Count, Microbial', 'Cryptococcus', 'Deoxycholic Acid', 'Drug Combinations', 'Female', 'Flucytosine', 'HIV Infections', 'Humans', 'Infusions, Intravenous', 'Male', 'Meningitis, Cryptococcal', 'Microbial Viability', 'Middle Aged', 'Treatment ... | 20,121,575 | [['M01.060.116'], ['D02.540.576.500.500'], ['D27.505.954.122.136'], ['A12.207.270.210'], ['E01.370.225.875.220', 'E05.200.875.220'], ['B01.300.381.258', 'B01.300.930.316'], ['D04.210.500.105.225.272', 'D04.210.500.221.430.342'], ['D26.310'], ['D03.383.742.698.421.431'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.7... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Sun Exposure, Tanning Beds, and Herbs That Cure: An Examination of Skin Cancer on Pinterest. | Skin cancer is the most common cancer affecting the U.S.POPULATION: Pinterest.com, a virtual bookmarking social media site, has the potential to disseminate skin cancer-related information among young women, the group with the fastest increase in skin cancer diagnosis. This article presents a quantitative content analy... | ['Carcinoma, Basal Cell', 'Carcinoma, Squamous Cell', 'Culture', 'Female', 'Humans', 'Melanoma', 'Plants, Medicinal', 'Risk Factors', 'Skin Neoplasms', 'Social Media', 'Sunbathing', 'Sunburn', 'Ultraviolet Rays'] | 27,588,747 | [['C04.557.470.200.165', 'C04.557.470.565.165'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['I01.076.201.450', 'I01.880.853.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.465.625.650.510', 'C04.557.580.625.650.510', 'C04.557.665.510'], ['B01.650.560'], ['E05.318.740.600.800.725', 'N05.715.350.2... | ['Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Information Science [L]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 |
Gene structure and expression of the glutathione S-transferase, SiGSTS1, from the red imported fire ant, Solenopsis invicta. | The structural organization and developmental expression of a previously described glutathione S-transferase cDNA from the red imported fire ant, Solenopsis invicta, were elucidated. The gene was previously named Solenopsis invicta, glutathione S-transferase, sigma class no. 1 (SiGSTS1). Comparison of genomic and cDNA ... | ['Animals', 'Ants', 'Base Sequence', 'DNA, Complementary', 'Exons', 'Female', 'Gene Expression Regulation, Enzymologic', 'Genes, Insect', 'Glutathione Transferase', 'Introns', 'Molecular Sequence Data', 'Polymerase Chain Reaction'] | 16,552,769 | [['B01.050'], ['B01.050.500.131.617.720.500.500.875.205'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D13.444.308.497.220', 'D13.444.600.223.500', 'D27.720.470.530.600.223.260'], ['G05.360.340.024.340.137.232'], ['G05.308.320'], ['G05.360.340.024.340.340', 'G05.360.340.357.500'], ['D08.811.913.225.500... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Secoisolariciresinol dehydrogenase purification, cloning, and functional expression. Implications for human health protection. | Matairesinol is a central precursor in planta in the biosynthesis of numerous lignans, including that of the important antiviral and anticancer agent, podophyllotoxin. In this study, the approximately 32-kDa NAD-dependent secoisolariciresinol dehydrogenase, which catalyzes the enantiospecific conversion of (-)-secoisol... | ['Alcohol Oxidoreductases', 'Amino Acid Sequence', 'Asteraceae', 'Base Sequence', 'Butylene Glycols', 'Cloning, Molecular', 'DNA, Complementary', 'Escherichia coli', 'Gene Library', 'Humans', 'Kinetics', 'Lignans', 'Molecular Sequence Data', 'Molecular Weight', 'NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases', ... | 11,278,426 | [['D08.811.682.047'], ['G02.111.570.060', 'L01.453.245.667.060'], ['B01.650.940.800.575.912.250.100'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D02.033.455.125'], ['E05.393.220'], ['D13.444.308.497.220', 'D13.444.600.223.500', 'D27.720.470.530.600.223.260'], ['B03.440.450.425.325.300', 'B03.660.250.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
[Acute pulmonary oedema associated with laryngospasm after thyroidectomy: a case report]. | In this paper, a case report of acute pulmonary oedema following thyroidectomy in a 51-year-old male patient is reported. The aetiological factor was vigorous inspiratory effort against an obstruction of the upper airway occurring immediately after extubation. The patient was transferred to intensive care unit and trea... | ['Acute Disease', 'Humans', 'Laryngismus', 'Male', 'Middle Aged', 'Pulmonary Edema', 'Thyroidectomy'] | 18,689,183 | [['C23.550.291.125'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C08.360.895.500', 'C08.618.980.500', 'C09.400.895.500'], ['M01.060.116.630'], ['C08.381.742'], ['E04.270.856']] | ['Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Two-Point Dynamic Observation of Alzheimer's Disease Cerebrospinal Fluid Biomarkers in Idiopathic Normal Pressure Hydrocephalus. | BACKGROUND: Extensive research into cerebrospinal fluid (CSF) biomarkers was performed in patients with idiopathic normal pressure hydrocephalus (iNPH). Most prior research into CSF biomarkers has been one-point observation.OBJECTIVE: To investigate dynamic changes in CSF biomarkers during routine tap test in iNPH pati... | ['Aged', 'Aged, 80 and over', 'Alzheimer Disease', 'Amyloid beta-Peptides', 'Biomarkers', 'Female', 'Humans', 'Hydrocephalus, Normal Pressure', 'Male', 'Peptide Fragments', 'Spinal Puncture', 'tau Proteins'] | 31,561,378 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['D12.644.024', 'D12.776.049.407.249.500', 'D12.776.543.039.500'], ['D23.101'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.228.140.602.750'], ['D12.644.541'], ['E01.370.225.998.054.790', 'E01.370.37... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Sevoflurane output from the Oxford Miniature Vaporizer in drawover mode. | The sevoflurane output from the Oxford Miniature Vaporizer (OMV) was measured in a series of bench tests in a drawover system. Using a range of settings on two OMVs in series, output ranged from 0.5 to 5.9% with a 600 ml tidal volume at a rate of 12 breaths/min produced by a Penlon Multivent. The OMVs' output was stead... | ['Anesthesiology', 'Anesthetics, Inhalation', 'Equipment Design', 'Methyl Ethers', 'Nebulizers and Vaporizers', 'Sevoflurane'] | 11,094,669 | [['H02.403.066'], ['D27.505.696.277.100.035.060', 'D27.505.954.427.210.100.035.060'], ['E05.320'], ['D02.355.601'], ['E07.605'], ['D02.355.601.810', 'D02.455.526.510.717']] | ['Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Hereditary abnormalities of thyroxine-binding globulin concentration. A study of 19 kindreds with inherited increase or decrease of thyroxine-binding globulin. | Nineteen families with hereditary abnormalities of thyroxine-binding globulin (TBG) have been studied, comprising a total of 15 males with absent TBG, and 15 females heterozygotic for this condition, and 14 males with excess of TBG and 44 heterozygotic females. Hereditary TBG excess was associated with thyrotoxicosis i... | ['Adult', 'Alpha-Globulins', 'Blood Protein Disorders', 'Child', 'Female', 'Humans', 'Hyperthyroidism', 'Infant', 'Male', 'Middle Aged', 'Myxedema', 'Pedigree', 'Thyroxine', 'Thyroxine-Binding Proteins', 'Triiodothyronine'] | 6,162,169 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
M?nchausen's syndrome by proxy. A little-known type of abuse. | Clinical decisions are guided by a patient's medical history and symptoms, but when the history is factitious or the symptoms are produced, such decisions may have catastrophic results. In M?nchausen's syndrome by proxy, patients are at the mercy of "illness manufacturers." Drs Leonard and Farrell discuss characteristi... | ['Aged', 'Child', 'Child, Preschool', 'Female', 'Humans', 'Infant', 'Male', 'Munchausen Syndrome by Proxy'] | 1,561,159 | [['M01.060.116.100'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['F03.875.375.800']] | ['Named Groups [M]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Validity of a rapid and simple fluorometric tripeptidyl peptidase 1 (TPP1) assay using dried blood specimens to diagnose CLN2 disease. | PURPOSE: CLN2 disease is a genetic disorder caused by dysfunction of the lysosomal enzyme tripeptidyl peptidase 1 (TPP1) that belongs to the neuronal ceroid lipofuscinoses (NCL) and leads to epilepsy, dementia, and death in young persons. CLN2 disease has recently become treatable by enzyme replacement, which can only ... | ['Aminopeptidases', 'Dipeptidyl-Peptidases and Tripeptidyl-Peptidases', 'Dried Blood Spot Testing', 'Female', 'Fluorometry', 'Humans', 'Male', 'Neuronal Ceroid-Lipofuscinoses', 'Phenotype', 'Serine Proteases', 'Time Factors'] | 30,771,299 | [['D08.811.277.656.350.100'], ['D08.811.277.656.350.350'], ['E01.370.225.124.100.232', 'E05.200.124.100.232'], ['E05.196.712.516.600'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.574.500.550', 'C16.320.400.600', 'C16.320.565.398.641.509', 'C18.452.584.687.509', 'C18.452.648.398.641.509'], ['G05.695'], ['D08... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Indirect effects and traditional trophic cascades: a test involving wolves, coyotes, and pronghorn. | The traditional trophic cascades model is based on consumer resource interactions at each link in a food chain. However, trophic-level interactions, such as mesocarnivore release resulting from intraguild predation, may also be important mediators of cascades. From September 2001 to August 2004, we used spatial and sea... | ['Animals', 'Antelopes', 'Competitive Behavior', 'Coyotes', 'Ecosystem', 'Female', 'Food Chain', 'Male', 'Population Density', 'Population Dynamics', 'Predatory Behavior', 'Spatial Behavior', 'Wolves'] | 18,459,344 | [['B01.050'], ['B01.050.150.900.649.313.500.380.100'], ['F01.145.813.105'], ['B01.050.150.900.649.313.750.250.216.150'], ['G16.500.275.157', 'N06.230.124'], ['G16.500.275.157.250', 'N06.230.124.250'], ['N01.224.600', 'N06.850.505.400.600'], ['I01.240.600', 'N01.224.625', 'N06.850.505.400.700'], ['F01.145.113.111.600', ... | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Highly Acidic Ambient Particles, Soluble Metals, and Oxidative Potential: A Link between Sulfate and Aerosol Toxicity. | Soluble transition metals in particulate matter (PM) can generate reactive oxygen species in vivo by redox cycling, leading to oxidative stress and adverse health effects. Most metals, such as those from roadway traffic, are emitted in an insoluble form, but must be soluble for redox cycling. Here we present the mechan... | ['Aerosols', 'Air Pollutants', 'Environmental Monitoring', 'Metals', 'Particle Size', 'Particulate Matter', 'Sulfates'] | 28,141,928 | [['D20.280.055', 'D26.255.165.055'], ['D27.888.284.101'], ['N06.850.460.350.080', 'N06.850.780.375'], ['D01.552'], ['G02.712'], ['D20.633'], ['D01.248.497.158.845', 'D01.875.800.800.850']] | ['Chemicals and Drugs [D]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy. | Many tumors overexpress mutant forms of p53. A growing number of studies suggest that the nature of a p53 mutation in a cell can impact upon cellular properties, clinical responses to therapy and prognosis of a tumor. To explore the cellular basis of these observations, experiments were designed to compare the properti... | ['Adenocarcinoma', 'Antineoplastic Agents', 'Blotting, Western', 'Cell Separation', 'Cell Survival', 'Cisplatin', 'Drug Resistance, Neoplasm', 'Etoposide', 'Flow Cytometry', 'Fluorescent Antibody Technique, Indirect', 'Genes, p53', 'Humans', 'Lung Neoplasms', 'Mutation'] | 9,927,204 | [['C04.557.470.200.025'], ['D27.505.954.248'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['E01.370.225.500.363', 'E05.200.500.363', 'E05.242.363'], ['G04.346'], ['D01.210.375', 'D01.625.125', 'D01.710.100'], ['G07.690.773.984.395'], ['D02.455.426.559.847.638.96... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The epidemiological characteristics and molecular phylogeny of the dengue virus in Guangdong, China, 2015. | In 2015, an unexpected multiple outbreak of dengue occurred in Guangdong, China. In total, 1,699 cases were reported, of which 1,627 cases were verified to have DENV infections by nucleic acid or NS1 protein, including 44 DENV-1, 1126 DENV-2, 18 DENV-3 and 6 DENV-4, and the other cases were confirmed by NS1 ELISA. Phyl... | ['Adolescent', 'Adult', 'Aedes', 'Aged', 'Animals', 'Child', 'Child, Preschool', 'China', 'Dengue', 'Dengue Virus', 'Disease Outbreaks', 'Female', 'Humans', 'Male', 'Middle Aged', 'Mosquito Vectors', 'Phylogeny'] | 29,967,414 | [['M01.060.057'], ['M01.060.116'], ['B01.050.500.131.617.720.500.500.750.712.500.875.100'], ['M01.060.116.100'], ['B01.050'], ['M01.060.406'], ['M01.060.406.448'], ['Z01.252.474.164'], ['C01.920.500.270', 'C01.925.081.270', 'C01.925.782.350.250.214', 'C01.925.782.417.214'], ['B04.820.578.344.350.270'], ['N06.850.290'],... | ['Named Groups [M]', 'Organisms [B]', 'Geographicals [Z]', 'Diseases [C]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Information Science [L]'] | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
Visual and auditory stimuli associated with swallowing: an FMRI study. | We focused on brain areas activated by audiovisual stimuli related to swallowing motions. In this study, three kinds of stimuli related to human swallowing movement (auditory stimuli alone, visual stimuli alone, or audiovisual stimuli) were presented to the subjects, and activated brain areas were measured using fMRI a... | ['Acoustic Stimulation', 'Adult', 'Brain Mapping', 'Deglutition', 'Female', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Motor Cortex', 'Photic Stimulation', 'Prefrontal Cortex', 'Young Adult'] | 20,179,392 | [['E02.037', 'E02.190.888.030', 'E05.723.136'], ['M01.060.116'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['G10.261.178'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['A08.186.211.200.885.287.500.270.548', 'A08.186.211.200.885.287.500.814.624'], ['E05.723... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A comparison of enamel erosion by a new sports drink compared to two proprietary products: a controlled, crossover study in situ. | OBJECTIVE: The aim of the study was to measure the erosive potential of a prototype sports drink on enamel in a model in situ.METHODS: The study was a single centre, single blind, randomised crossover design balanced for residual effects involving 18 subjects. The drinks were the prototype formulation containing calciu... | ['Adult', 'Beverages', 'Calcium', 'Cohort Studies', 'Cross-Over Studies', 'Dental Enamel', 'Female', 'Follow-Up Studies', 'Glucose', 'Humans', 'Hydrogen-Ion Concentration', 'Male', 'Maltose', 'Polysaccharides', 'Single-Blind Method', 'Sports', 'Sucrose', 'Tooth Erosion'] | 15,304,299 | [['M01.060.116'], ['G07.203.100', 'J02.200'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E05.318.370.150', 'N05.715.360.325.150', 'N06.850.520.445.150'], ['A14.549.167.900.255'], ['E05.318.372.500.750.249', 'N05.715.360.330.500... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Diseases... | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 |
Towards temperature-dependent coarse-grained potentials of side-chain interactions for protein folding simulations. I: molecular dynamics study of a pair of methane molecules in water at various temperatures. | By means of molecular dynamics simulations of a pair of methane molecules in a TIP3P periodic water box with the NVT scheme at six temperatures and, additionally, the NPT scheme at three temperatures ranging from T = 283 to 373 K, we determined the potential of mean force (PMF) of pairs of interacting methane molecules... | ['Algorithms', 'Computer Simulation', 'Hydrophobic and Hydrophilic Interactions', 'Methane', 'Models, Chemical', 'Models, Molecular', 'Protein Conformation', 'Protein Folding', 'Temperature', 'Water'] | 19,556,395 | [['G17.035', 'L01.224.050'], ['L01.224.160'], ['G02.409'], ['D02.455.326.146.571'], ['E05.599.495'], ['E05.599.595'], ['G02.111.570.820.709'], ['G01.154.651', 'G02.111.688'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.150.450', 'N06.230.300.100.725.710'], ['D01.045.250.875', 'D01.248.497... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Development of the anti-gp120 antibody response during seroconversion to human immunodeficiency virus type 1. | We have studied the development of the antibody response to the surface glycoprotein gp120 of human immunodeficiency virus type 1 in three individuals who presented with primary human immunodeficiency virus type 1 infection syndrome. Serum anti-gp120 antibodies were first detected 4 to 23 days after presentation, after... | ['Amino Acid Sequence', 'Antibodies, Monoclonal', 'Antibody Specificity', 'Cells, Cultured', 'HIV Antibodies', 'HIV Envelope Protein gp120', 'HIV Seropositivity', 'HIV-1', 'Humans', 'Molecular Sequence Data', 'Neutralization Tests'] | 8,035,514 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['G12.100'], ['A11.251'], ['D12.776.124.486.485.114.254.150.440', 'D12.776.124.790.651.114.254.150.440', 'D12.776.377.715.548.114.254.150.440'], ['D12.776.964.775.325.164.249', 'D1... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Distinct LTP induction mechanisms: contribution of NMDA receptors and voltage-dependent calcium channels. | 1. Our results indicate that there are two distinct components of long-term potentiation (LTP) induced by the K+ channel blocker tetraethylammonium chloride (TEA) at synapses of hippocampal CA1 pyramidal neurons. Preincubation of hippocampal slices in the N-methyl-D-aspartate (NMDA) receptor antagonist D,L-2-amino-5 ph... | ['Animals', 'Calcium Channels', 'Hippocampus', 'Long-Term Potentiation', 'Nifedipine', 'Patch-Clamp Techniques', 'Rats', 'Rats, Sprague-Dawley', 'Receptors, N-Methyl-D-Aspartate'] | 7,714,571 | [['B01.050'], ['D12.776.157.530.400.150', 'D12.776.543.550.450.150', 'D12.776.543.585.400.150'], ['A08.186.211.180.405', 'A08.186.211.200.885.287.500.345'], ['G11.561.638.350'], ['D03.383.725.203.540'], ['E05.200.500.905', 'E05.242.800'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.50... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endovascular management of an acquired aortobronchial fistula following aortic bypass for coarctation. | Aortobronchial fistula (ABF) in the setting of aortic coarctation repair is very rare but uniformly fatal if untreated. Endovascular stenting of the descending aorta is now the first-choice approach for ABF presenting with haemoptysis and offers a less-invasive technique with improved outcomes, compared with open repai... | ['Angiography, Digital Subtraction', 'Angioplasty, Balloon', 'Aortic Coarctation', 'Aortic Diseases', 'Aortography', 'Blood Vessel Prosthesis Implantation', 'Bronchial Fistula', 'Hemoptysis', 'Humans', 'Male', 'Middle Aged', 'Stents', 'Time Factors', 'Tomography, X-Ray Computed', 'Treatment Outcome', 'Vascular Fistula'... | 24,057,860 | [['E01.370.350.600.350.700.060', 'E01.370.350.700.060.060', 'E01.370.350.700.700.060', 'E01.370.350.760.060', 'E01.370.370.050.060'], ['E02.148.050.060', 'E04.100.814.529.124.060', 'E04.502.382.124.060', 'E05.157.016.060'], ['C14.240.400.090', 'C14.280.400.090', 'C16.131.240.400.090'], ['C14.907.109'], ['E01.370.350.70... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Cricotracheal resection with hilar release for pediatric airway stenosis. | OBJECTIVE: To determine the effectiveness of cricotracheal resection and hilar release for high-grade, long-segment airway stenosis.DESIGN: We identified 16 patients who underwent cricotracheal resection and hilar release, performed from January 1, 2004, through December 31, 2008, and conducted a retrospective review, ... | ['Adolescent', 'Child', 'Child, Preschool', 'Cricoid Cartilage', 'Female', 'Humans', 'Infant', 'Laryngostenosis', 'Male', 'Postoperative Complications', 'Retrospective Studies', 'Severity of Illness Index', 'Thoracotomy', 'Trachea', 'Tracheomalacia', 'Treatment Outcome'] | 20,231,643 | [['M01.060.057'], ['M01.060.406'], ['M01.060.406.448'], ['A02.165.257.625.211', 'A02.165.407.500.211', 'A04.329.591.211'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['C08.360.591', 'C09.400.591', 'C16.131.740.658'], ['C23.550.767'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715... | ['Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Establishing process indicators for joint working in mental health: rationale and results from a national survey. | Effective joint working in mental health is a national concern as indicated by a series of governmental directives and initiatives aimed at improving practice in this area. Joint working is fundamental to the successful implementation of 'community care'. Many people, particularly the public, equate the introduction of... | ['Community Mental Health Services', 'Cooperative Behavior', 'Health Care Surveys', 'Humans', 'Interinstitutional Relations', 'Process Assessment, Health Care', 'Program Evaluation', 'State Medicine', 'United Kingdom'] | 11,725,580 | [['F04.408.307', 'N02.421.143.183', 'N02.421.461.232'], ['F01.145.813.115'], ['E05.318.308.980.344', 'N03.349.380.210', 'N05.425.210', 'N05.715.360.300.800.344', 'N06.850.520.308.980.344'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N04.452.822.400'], ['N04.761.559.650', 'N05.715.360.575.625'], ['E05.337.820', ... | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Dexamethasone resistance in B-cell precursor childhood acute lymphoblastic leukemia occurs downstream of ligand-induced nuclear translocation of the glucocorticoid receptor. | Glucocorticoids are among the most effective agents used in the treatment of childhood acute lymphoblastic leukemia (ALL), and patient response to treatment is an important determinant of long-term outcome. Despite its clinical significance, the molecular basis of glucocorticoid resistance in lymphoid malignancies is s... | ['Active Transport, Cell Nucleus', 'Adolescent', 'Animals', 'Antineoplastic Agents, Hormonal', 'Apoptosis', 'Apoptosis Regulatory Proteins', 'Bcl-2-Like Protein 11', 'Burkitt Lymphoma', 'Cell Nucleus', 'Child', 'Child, Preschool', 'Dexamethasone', 'Drug Resistance, Neoplasm', 'Female', 'Gene Expression Regulation, Leuk... | 15,572,593 | [['G03.143.310.100', 'G03.143.700.100'], ['M01.060.057'], ['B01.050'], ['D27.505.954.248.169'], ['G04.146.954.035'], ['D12.644.360.075', 'D12.776.476.075'], ['D12.644.360.075.323', 'D12.776.476.075.323', 'D12.776.543.116', 'D12.776.624.664.700.025'], ['C01.925.256.466.313.165', 'C01.925.928.313.165', 'C04.557.386.480.1... | ['Phenomena and Processes [G]', 'Named Groups [M]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Prediction of central lymph node metastasis in patientswith thyroid papillary microcarcinoma | Background/aim: The purpose of this study was to analyze the clinicopathological characteristics of patients with papillary thyroid carcinoma (PTC) and papillary thyroid microcarcinoma (PTMC) and predictive factors for central lymph node metastasis (CLNM).Materials and methods: Patients diagnosed as having PTC and PTMC... | ['Adult', 'Age Factors', 'Carcinoma, Papillary', 'Female', 'Humans', 'Lymph Nodes', 'Lymphatic Metastasis', 'Male', 'Middle Aged', 'Neck Dissection', 'Neoplasm Recurrence, Local', 'Retrospective Studies', 'Risk Factors', 'Sex Factors', 'Thyroid Gland', 'Thyroid Neoplasms'] | 29,306,230 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['C04.557.470.200.360', 'C04.557.470.700.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A10.549.400', 'A15.382.520.604.412'], ['C04.697.650.560', 'C23.550.727.650.560'], ['M01.060.116.630'], ['E04.446.318', 'E04.580.411'], ['C04.697.655', 'C23.550.727... | ['Named Groups [M]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
CD4 down-regulation by nef alleles isolated from human immunodeficiency virus type 1-infected individuals. | PCR was used to clone isolates of the human immunodeficiency virus type 1 (HIV-1) nef gene directly from peripheral blood leukocytes of HIV-1-infected individuals. A transient expression system with human CEM T cells was used to assess the effect of nef on CD4 antigen expression on the cell surface. We show that CD4 do... | ['Acquired Immunodeficiency Syndrome', 'Alleles', 'Amino Acid Sequence', 'Base Sequence', 'CD4 Antigens', 'DNA, Viral', 'Down-Regulation', 'Gene Products, nef', 'Genes, nef', 'HIV-1', 'Humans', 'Leukocytes', 'Molecular Sequence Data', 'Mutation', 'Oligodeoxyribonucleotides', 'Open Reading Frames', 'Polymerase Chain Rea... | 8,516,299 | [['C01.221.250.875.040', 'C01.221.812.640.400.040', 'C01.778.640.400.040', 'C01.925.782.815.616.400.040', 'C01.925.813.400.040', 'C01.925.839.040', 'C20.673.480.040'], ['G05.360.340.024.340.030'], ['G02.111.570.060', 'L01.453.245.667.060'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D12.776.543.750.70... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Lone Actor Terrorist Attack Planning and Preparation: A Data-Driven Analysis. | This article provides an in-depth assessment of lone actor terrorists' attack planning and preparation. A codebook of 198 variables related to different aspects of pre-attack behavior is applied to a sample of 55 lone actor terrorists. Data were drawn from open-source materials and complemented where possible with prim... | ['Aggression', 'Criminal Behavior', 'Forensic Psychiatry', 'Humans', 'Motivation', 'Psychology, Social', 'Risk Factors', 'Social Identification', 'Social Isolation', 'Terrorism', 'Weapons'] | 29,059,713 | [['F01.145.126.125', 'F01.145.813.045'], ['F01.145.250'], ['F04.096.544.335', 'H02.403.690.208', 'I01.198.780.937.469', 'I01.880.604.583.310', 'N03.706.535.351'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.658', 'F01.752.543.500.750'], ['F01.829', 'F04.096.628.829'], ['E05.318.740.600.800.725', 'N05.715.350... | ['Psychiatry and Psychology [F]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 |
Serum levels of interleukin-18 (IL-18) and soluble interleukin-2 receptor (sIL-2R) in lung cancer. | PURPOSE: We evaluated the clinical usefulness of interleukin-18 (IL-18) and soluble interleukin-2 receptor (sIL-2R) during chemotherapy of lung cancer in relation to the histological type of the tumor, clinical stage, response to therapy and time survival.MATERIAL AND METHODS: Serum levels of IL-18 and sIL-2R were dete... | ['Antineoplastic Agents', 'Biomarkers, Tumor', 'Carcinoma, Non-Small-Cell Lung', 'Carcinoma, Small Cell', 'Case-Control Studies', 'Female', 'Humans', 'Interleukin-18', 'Lung Neoplasms', 'Male', 'Middle Aged', 'Neoplasm Staging', 'Receptors, Interleukin-2'] | 15,631,351 | [['D27.505.954.248'], ['D23.101.140'], ['C04.588.894.797.520.109.220.249', 'C08.381.540.140.500', 'C08.785.520.100.220.500'], ['C04.557.470.200.380'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.465.518', 'D12.776.467.... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Mitochondrial Specific H2 | Reactive sulfur species play a very important role in modulating neural signal transmission. Hydrogen polysulfides (H2S n, n > 1) are recently suggested to be the actual signaling molecules. There are still few spatiotemporal controllable-based probes to detect H2S n. In this work, for the first time, we proposed the p... | ['Fluoresceins', 'Fluorescent Dyes', 'Hep G2 Cells', 'Humans', 'Limit of Detection', 'Microscopy, Confocal', 'Microscopy, Fluorescence', 'Mitochondria', 'Nitrobenzoates', 'Organophosphorus Compounds', 'Sulfides', 'Ultraviolet Rays'] | 30,145,883 | [['D02.455.426.779.347', 'D03.633.300.953.275', 'D04.711.347'], ['D27.720.233.348', 'D27.720.470.410.505.500'], ['A11.251.860.180.432', 'A11.436.348.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.872.374', 'N05.715.360.750.725.500', 'N06.850.520.830.872.500'], ['E01.370.350.515.395', 'E05.595.395... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Endotoxin down-regulates monocyte and granulocyte interleukin-6 receptors without influencing gp130 expression in humans. | Interleukin (IL)-6 is important for host defense against various pathogens. The IL-6 receptor (IL-6R) complex consists of a ligand-binding component (IL-6R) and a signal-transducing component (gp130). In a study designed to obtain insight into the regulation of this receptor complex during inflammation, 8 healthy subje... | ['Adult', 'Antigens, CD', 'Cytokine Receptor gp130', 'Down-Regulation', 'Endotoxemia', 'Granulocytes', 'Growth Inhibitors', 'Humans', 'Interleukin-6', 'Leukemia Inhibitory Factor', 'Lipopolysaccharides', 'Lymphokines', 'Male', 'Membrane Glycoproteins', 'Monocytes', 'Receptors, Interleukin-6'] | 10,720,531 | [['M01.060.116'], ['D23.050.301.264.035', 'D23.101.100.110'], ['D12.776.543.750.705.852.420.400.500', 'D12.776.543.750.705.852.420.560.249', 'D12.776.543.750.705.852.555.600.500', 'D12.776.543.750.705.852.583.500', 'D12.776.543.750.750.400.550.250.500'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['C01.757.100.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Effect of Rosuvastatin in Preventing Chemotherapy-Induced Cardiotoxicity in Women With Breast Cancer: A Randomized, Single-Blind, Placebo-Controlled Trial. | OBJECTIVE: Chemotherapy-induced cardiotoxicity is a major and leading cause of death in breast cancer survivors. It can present decades after chemotherapy and can manifest in different ways; some chemotherapeutic agents have a powerful dose-dependent relationship with cardiotoxicity. The aim of this study was to invest... | ['Adult', 'Aged', 'Antineoplastic Agents', 'Breast Neoplasms', 'Cardiotoxicity', 'Echocardiography, Doppler', 'Female', 'Humans', 'Iran', 'Middle Aged', 'Prospective Studies', 'Protective Agents', 'Rosuvastatin Calcium', 'Single-Blind Method', 'Stroke Volume', 'Time Factors', 'Treatment Outcome', 'Ventricular Dysfuncti... | 30,599,756 | [['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.248'], ['C04.588.180', 'C17.800.090.500'], ['C14.280.260', 'C23.550.161', 'C25.100.389', 'C26.733.266', 'G01.750.748.500.266'], ['E01.370.350.130.750.220', 'E01.370.350.850.220.220', 'E01.370.350.850.850.220', 'E01.370.370.380.220.220'], ['B01.050.150.900.649.313.988... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
[Cooperation between criminal investigators and forensic medicine. A complementary system and its peculiarities, illustrated by a case from general practice]. | Usually criminal investigations involving issues of medical misconduct require comprehensive inquiries which normally include the confiscation of medical files and the determination of certain events in their chronological order. This information is then submitted to the relevant experts as a basis for preparing their ... | ['Appetite Depressants', 'Coroners and Medical Examiners', 'Criminal Law', 'Expert Testimony', 'Female', 'Germany', 'Humans', 'Interprofessional Relations', 'Male', 'Malpractice'] | 11,901,982 | [['D27.505.954.203.155'], ['M01.526.485.230', 'N02.360.230'], ['I01.198.290', 'I01.880.604.583.100'], ['I01.880.604.583.232', 'N03.706.535.253'], ['Z01.542.315'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.401.205'], ['I01.880.604.583.524', 'N03.706.535.606']] | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
[The complete mitochondrial genome of peacock sole Pardachirus pavoninus (Pleuronectiformes: Soleidae) and comparative analysis of the control region among 13 soles]. | The complete mitogenome of the peacock sole Pardachirus pavoninus (Lacep?de, 1802) was determined. The total length is 16 536 bp, containing 13 protein-coding genes, 22 tRNA genes and two rRNA genes, as well as one control region (CR). The L-strand replication origin (OL), which is typically located in the WANCY cluste... | ['Animals', 'Base Sequence', 'Chromosome Mapping', 'Conserved Sequence', 'Flatfishes', 'Genes, Mitochondrial', 'Genes, rRNA', 'Genome, Mitochondrial', 'Locus Control Region', 'Mitochondria', 'Molecular Sequence Data', 'Phylogeny', 'Tandem Repeat Sequences'] | 26,107,900 | [['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.393.183'], ['G02.111.570.580'], ['B01.050.150.900.493.418'], ['G05.360.340.024.340.365', 'G05.420.275.500'], ['G05.360.340.024.340.645.750'], ['G05.360.340.360'], ['G02.111.570.080.689.450', 'G05.360.080.689.450', 'G05.360.340.024.380.249'],... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Regional assignment of the mouse alpha A2-crystallin gene (Crya-1) to chromosome 17A3----B by in situ hybridization. | Previously, we assigned the alpha A2-crystallin (Crya-1) structural gene to mouse chromosome 17 via Southern blot hybridization analysis of mouse x Chinese hamster somatic cell hybrids. Using in situ hybridization, we have now localized this gene to 17A3----B, a subchromosomal region containing several genes whose link... | ['Animals', 'Chromosome Mapping', 'Crystallins', 'DNA Probes', 'Genes', 'Genetic Linkage', 'Mice', 'Nucleic Acid Hybridization'] | 2,369,847 | [['B01.050'], ['E05.393.183'], ['D12.776.306.366'], ['D13.444.600.223', 'D27.505.259.750.600.223', 'D27.720.470.530.600.223'], ['G05.360.340.024.340'], ['G05.348'], ['B01.050.150.900.649.313.992.635.505.500'], ['E05.393.661', 'G02.111.611']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Evaluation of a rapid immunodiagnostic rabies field surveillance test on samples collected from military operations in Africa, Europe, and the Middle East. | The Anigen Rapid Rabies Antigen Test Kit (Bionote, Inc, Hwaseong, Korea) was evaluated using 80 clinical samples collected by US military veterinary units. Samples for the study were obtained from brain specimens of domestic and wildlife animals that were submitted to the US Army Public Health Command's Veterinary Labo... | ['Africa', 'Antigens, Viral', 'Brain', 'Europe', 'Fluorescent Antibody Technique, Direct', 'Humans', 'Immunologic Tests', 'Middle East', 'Military Medicine', 'Population Surveillance', 'Rabies', 'Rabies virus', 'Sensitivity and Specificity', 'Veterinary Service, Military'] | 25,074,599 | [['Z01.058'], ['D23.050.327'], ['A08.186.211'], ['Z01.542'], ['E01.370.225.500.607.512.240.300', 'E01.370.225.750.551.512.240.300', 'E05.200.500.607.512.240.300', 'E05.200.750.551.512.240.300', 'E05.478.583.375.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.812', 'E05.200.812', 'E05.478.594'], ['... | ['Geographicals [Z]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
Connectionism and the learning of probabilistic concepts. | Three experiments examine the claim of Gluck and Bower (1986, 1988a, 1988b) that the learning of medical concepts can be simulated by a connectionist network in which the symptoms are the input and the diagnosis is the output. The first experiment replicates the main finding of Gluck and Bower. In this experiment, subj... | ['Adult', 'Concept Formation', 'Diagnosis, Differential', 'Humans', 'Probability Learning', 'Reproducibility of Results'] | 2,367,681 | [['M01.060.116'], ['F02.463.785.233'], ['E01.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.425.701'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Characteristics of nutrition status of elementary age of Tuzla's region]. | Nutrition status is a reflection nutrition process. For assessment of the nutrition status most valuable data are the physical weight, height and the skin pleat thickness. It is quiet impossible to review the influence of malnutrition on health by medical statistics, because the nutritive deficits are mostly not follow... | ['Adolescent', 'Body Mass Index', 'Bosnia and Herzegovina', 'Child', 'Child Nutrition Disorders', 'Female', 'Humans', 'Male', 'Nutritional Status', 'Overweight'] | 17,629,145 | [['M01.060.057'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['Z01.542.248.160'], ['M01.060.406'], ['C18.654.180'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G07.203.650.650', 'N01.224.425.525'], ['C23.888.144.699', 'E01.370.600.115.100.160.120.699', 'G07.100.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Geographicals [Z]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Hypertension induces somatic cellular senescence in rats and humans by induction of cell cycle inhibitor p16INK4a. | There is increasing evidence for a role of somatic cellular senescence in physiological aging but also in injury and disease. Cell cycle inhibitor p16(INK4a) is the key mediator for stress and aberrant signaling induced senescence. Here we report that elevated blood pressure markedly induced p16(INK4a) expression in ra... | ['Angiotensin II Type 1 Receptor Blockers', 'Animals', 'Animals, Genetically Modified', 'Antihypertensive Agents', 'Blood Pressure', 'Cellular Senescence', 'Cyclin-Dependent Kinase Inhibitor p16', 'Desoxycorticosterone', 'Heart Ventricles', 'Humans', 'Hydralazine', 'Hydrochlorothiazide', 'Hypertension, Renal', 'Kidney'... | 18,504,326 | [['D27.505.519.162.500'], ['B01.050'], ['B01.050.050.136', 'B05.620.136'], ['D27.505.954.411.162'], ['E01.370.600.875.249', 'G09.330.380.076'], ['G04.043'], ['D12.644.360.225.200', 'D12.776.167.187.200', 'D12.776.476.225.200', 'D12.776.624.776.355.200'], ['D04.210.500.745.745.654.339', 'D06.472.040.585.611'], ['A07.541... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Relationship between dopamine agonist stimulation of inositol phosphate formation and cytidine diphosphate-diacylglycerol accumulation in brain slices. | Dopamine receptor-coupled stimulation of inositol phosphate formation has been characterized extensively, but little is known about the diacylglycerol arm of this dual-signaling pathway. This study examined several parameters of cytidine diphosphate-diacylglycerol (CDP-DG) accumulation as an index of agonist-stimulated... | ['2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine', 'Animals', 'Brain', 'Cytidine Diphosphate', 'Diglycerides', 'Dopamine Agonists', 'Hydrolysis', 'In Vitro Techniques', 'Inositol Phosphates', 'Male', 'Neomycin', 'Rats', 'Rats, Sprague-Dawley', 'Stimulation, Chemical'] | 9,878,788 | [['D03.633.100.079.838'], ['B01.050'], ['A08.186.211'], ['D03.383.742.686.246.150', 'D13.695.740.246.150', 'D13.695.827.232.150'], ['D10.351.303'], ['D27.505.519.625.150.151', 'D27.505.696.577.150.151'], ['G02.380'], ['E05.481'], ['D02.033.800.519.400', 'D09.853.519.400', 'D09.894.480'], ['D09.408.051.623'], ['B01.050.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
All-trans retinoic acid improves the viability of ischemic skin flaps in diabetic rat models. | AIMS: Endothelial progenitor cells (EPCs) play a critical role in neovascularization, which enhances proliferation under all-trans retinoic acid (ATRA) treatment. However, the effects of ATRA on the skin flap survival in diabetic flap ischemia remains unknown.METHODS: Ischemic random skin flaps were made in 40 diabetic... | ['Animals', 'Diabetes Mellitus, Experimental', 'Disease Models, Animal', 'Ischemia', 'Male', 'Mice', 'Neovascularization, Physiologic', 'Postoperative Complications', 'Rats', 'Rats, Sprague-Dawley', 'Surgical Flaps', 'Tretinoin'] | 29,936,250 | [['B01.050'], ['C18.452.394.750.074', 'C19.246.240', 'E05.598.500.374'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['C23.550.513'], ['B01.050.150.900.649.313.992.635.505.500'], ['G09.330.630'], ['C23.550.767'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.750'], ['A10.850.... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Steady-state and presteady-state kinetics of the H+/hexose cotransporter (STP1) from Arabidopsis thaliana expressed in Xenopus oocytes. | We have investigated the steady-state and presteady-state kinetics of the cloned H+/hexose cotransporter from Arabidopsis thaliana (STP1) expressed in Xenopus oocytes using the two-electrode voltage-clamp method. Steady-state sugar-dependent currents were measured between -150 and +50 mV as a function of external [3-O-... | ['Animals', 'Arabidopsis', 'Biological Transport', 'Female', 'Hexoses', 'Hydrogen', 'Kinetics', 'Membrane Potentials', 'Monosaccharide Transport Proteins', 'Oocytes', 'Substrate Specificity', 'Xenopus laevis'] | 8,051,137 | [['B01.050'], ['B01.650.940.800.575.912.250.157.100'], ['G03.143'], ['D09.947.875.359'], ['D01.268.406', 'D01.362.340'], ['G01.374.661', 'G02.111.490'], ['G01.154.535', 'G04.580', 'G07.265.675', 'G11.561.570'], ['D12.776.157.530.500', 'D12.776.543.585.500'], ['A05.360.490.690.680', 'A11.497.497.600'], ['G02.111.835'], ... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A salicylic acid-induced lectin-like protein plays a positive role in the effector-triggered immunity response of Arabidopsis thaliana to Pseudomonas syringae Avr-Rpm1. | Salicylic acid (SA) is one of the key hormones that orchestrate the pathogen-induced immune response in plants. This response is often characterized by the activation of a local hypersensitive reaction involving programmed cell death, which constrains proliferation of biotrophic pathogens. Here, we report the identific... | ['Arabidopsis', 'Arabidopsis Proteins', 'Bacterial Proteins', 'Cell Death', 'Cell Membrane', 'Gene Expression Regulation, Plant', 'Glycoproteins', 'Lectins', 'Plant Diseases', 'Plant Immunity', 'Plant Leaves', 'Pseudomonas syringae', 'Salicylic Acid'] | 24,006,883 | [['B01.650.940.800.575.912.250.157.100'], ['D12.776.765.149'], ['D12.776.097'], ['G04.146'], ['A11.284.149'], ['G05.308.375'], ['D09.400.430', 'D12.776.395'], ['D12.776.503'], ['G15.610'], ['G12.450.800', 'G15.630'], ['A18.024.812'], ['B03.440.400.425.625.625.770', 'B03.660.250.580.590.770'], ['D02.241.223.100.300.595.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Actl6a protects embryonic stem cells from differentiating into primitive endoderm. | Actl6a (actin-like protein 6A, also known as Baf53a or Arp4) is a subunit shared by multiple complexes including esBAF, INO80, and Tip60-p400, whose main components (Brg1, Ino80, and p400, respectively) are crucial for the maintenance of embryonic stem cells (ESCs). However, whether and how Actl6a functions in ESCs has... | ['Actins', 'Animals', 'Blastocyst', 'Cell Differentiation', 'Cell Lineage', 'Chromosomal Proteins, Non-Histone', 'DNA-Binding Proteins', 'Endoderm', 'Gene Expression Regulation, Developmental', 'Germ Layers', 'Mice', 'Mouse Embryonic Stem Cells', 'Octamer Transcription Factor-3'] | 25,802,002 | [['D05.750.078.730.250', 'D12.776.210.500.100', 'D12.776.220.525.255'], ['B01.050'], ['A16.254.500'], ['G04.152'], ['G04.172', 'G07.345.500.325.180.500', 'G08.686.155', 'G08.686.784.170.104.249'], ['D12.776.660.235', 'D12.776.664.235'], ['D12.776.260'], ['A16.504.407'], ['G05.308.310'], ['A16.504'], ['B01.050.150.900.6... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of an 8-Week Body-Weight Neuromuscular Training on Dynamic Balance and Vertical Jump Performances in Elite Junior Skiing Athletes: A Randomized Controlled Trial. | Vitale, JA, La Torre, A, Banfi, G, and Bonato, M. Effects of an 8-week body-weight neuromuscular training on dynamic balance and vertical jump performances in elite junior skiing athletes: a randomized controlled trial. J Strength Cond Res 32(4): 911-920, 2018-The aim of the present randomized controlled trial was to e... | ['Adolescent', 'Athletes', 'Athletic Performance', 'Body Weight', 'Humans', 'Lower Extremity', 'Male', 'Muscle Strength', 'Muscle, Skeletal', 'Skiing', 'Warm-Up Exercise', 'Weight Lifting', 'Young Adult'] | 29,401,197 | [['M01.060.057'], ['M01.072'], ['I03.450.642.845.054'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A01.378.610'], ['E01.370.600.425', 'G11.427.560'], ['A02.633.567', 'A10.690.552.500'], ['I03.450... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Salinity and drought tolerant OsACA6 enhances cold tolerance in transgenic tobacco by interacting with stress-inducible proteins. | Plant Ca(2+)ATPases regulate many signalling pathways which are important for plant growth, development and abiotic stress responses. Our previous work identified that overexpression of OsACA6 confers salinity and drought tolerance in tobacco. In the present work we report, the function of OsACA6 in cold stress toleran... | ['Calcium-Transporting ATPases', 'Droughts', 'Gene Expression Regulation, Plant', 'Plant Proteins', 'Plants, Genetically Modified', 'Reactive Oxygen Species', 'Salinity', 'Tobacco'] | 24,992,889 | [['D08.811.277.040.025.314.250', 'D12.776.157.530.450.250.500', 'D12.776.157.530.813.250', 'D12.776.543.585.450.250.500', 'D12.776.543.585.813.250'], ['G16.500.175.781', 'G16.500.750.775.154', 'N06.230.100.230.150'], ['G05.308.375'], ['D12.776.765'], ['B01.650.520', 'B05.620.600'], ['D01.339.431', 'D01.650.775'], ['G02... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Immunogenicity of dimorphic and C-terminal fragments of Plasmodium falciparum MSP2 formulated with different adjuvants in mice. | BACKGROUND: Plasmodium falciparum MSP2 is a blood stage protein that is associated with protection against malaria. It was shown that the MSP2 dimorphic (D) and constant (C) regions were well recognized by immune human antibodies, and were characterized by major conserved epitopes in different endemic areas and age gro... | ['Adjuvants, Immunologic', 'Amino Acid Sequence', 'Animals', 'Antibodies, Protozoan', 'Antigens, Protozoan', 'Cells, Cultured', 'Epitope Mapping', 'Epitopes', 'Female', 'Glucosides', 'Humans', 'Immunoglobulin G', 'Lipid A', 'Malaria Vaccines', 'Mice, Inbred C3H', 'Mice, Inbred ICR', 'Molecular Sequence Data', 'Monocyte... | 26,874,325 | [['D27.505.696.477.067'], ['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D12.776.124.486.485.114.252', 'D12.776.124.790.651.114.252', 'D12.776.377.715.548.114.252'], ['D23.050.293'], ['A11.251'], ['E05.478.274', 'E05.601.690.300'], ['D23.050.550'], ['D09.408.348'], ['B01.050.150.900.649.313.988.400.112.400.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
miR-574-5p negatively regulates Qki6/7 to impact â-catenin/Wnt signalling and the development of colorectal cancer. | OBJECTIVE: Deficiency or reduced expression of signal transduction and activation of RNA family protein Quaking (Qki) is associated with developmental defects in neural and vascular tissues and the development of debilitating human diseases including colorectal cancer (CRC). However, the mechanisms underlying the aberr... | ['Animals', 'Biomarkers, Tumor', 'Colorectal Neoplasms', 'Cyclin-Dependent Kinase Inhibitor p27', 'Down-Regulation', 'Gene Expression Regulation, Neoplastic', 'Humans', 'Male', 'Mice', 'Mice, Inbred BALB C', 'Mice, Inbred C57BL', 'Mice, Nude', 'MicroRNAs', 'Neoplasms, Experimental', 'Protein Kinase Inhibitors', 'RNA-Bi... | 22,490,519 | [['B01.050'], ['D23.101.140'], ['C04.588.274.476.411.307', 'C06.301.371.411.307', 'C06.405.249.411.307', 'C06.405.469.158.356', 'C06.405.469.491.307', 'C06.405.469.860.180'], ['D12.644.360.225.600', 'D12.776.167.187.600', 'D12.776.476.225.600', 'D12.776.624.776.355.600'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Hyperbaric oxygen therapy as adjuvant for treating wound complications after extensive resection for vulvar malignancy. | Introduction: Necrosis, wound breakdown, and infection represent major complications associated with radical vulvectomy. We aimed to analyze the feasibility of hyperbaric oxygen (HBO₂) therapy as an adjunctive treatment for such complications.Methods: We performed a retrospective analysis of the medical records, clinic... | ['Adult', 'Aged', 'Aged, 80 and over', 'Combined Modality Therapy', 'Debridement', 'Feasibility Studies', 'Female', 'Humans', 'Hyperbaric Oxygenation', 'Ischemia', 'Middle Aged', 'Necrosis', 'Postoperative Complications', 'Reoperation', 'Retrospective Studies', 'Surgical Flaps', 'Surgical Wound', 'Surgical Wound Dehisc... | 29,571,229 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E02.186'], ['E04.176'], ['E05.318.372.550', 'E05.337.675', 'N05.715.360.330.550', 'N06.850.520.450.550'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.880.690.490'], ['C23.550.513'], ['M01.060.116.630'], ['C23.550.717'], ['C23.550.767'], ['E04.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Assessment of safety and efficacy of a bipolar fractionated radiofrequency device in the treatment of periorbital rhytides. | Bipolar radiofrequency (RF) has been used to treat photodamage. Periorbital rhytides are often difficult to treat. In this study bipolar RF was assessed in the 20 subjects, who are in treatment of periorbital rhytides and it was proved that it can successfully treat the periorbital rhytides. | ['Adult', 'Catheter Ablation', 'Female', 'Humans', 'Middle Aged', 'Prospective Studies', 'Radio Waves', 'Radiofrequency Therapy', 'Rhytidoplasty', 'Skin Aging', 'Treatment Outcome'] | 25,003,480 | [['M01.060.116'], ['E02.808.750.500', 'E04.014.760.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['G01.358.500.505.810', 'G01.750.250.810', 'G01.750.770.721'], ['E02.808'], ['E02.218.765', 'E04.680.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Effectiveness of a combined live mumps-measles vaccine]. | The reactogenic and areactogenic properties of a live combined mumps-measles vaccine (MMV) prepared in primary cultures of Japanese quail embryo cells from attenuated strains of mumps (L-3) and measles (L-16) viruses were under study. The observations involved 648 infants varying in ages from 1 to 3 years, seronegative... | ['Antibodies, Viral', 'Child, Preschool', 'Dose-Response Relationship, Immunologic', 'Drug Combinations', 'Drug Evaluation', 'Humans', 'Infant', 'Measles Vaccine', 'Measles virus', 'Mumps Vaccine', 'Mumps virus', 'Time Factors'] | 3,445,589 | [['D12.776.124.486.485.114.254', 'D12.776.124.790.651.114.254', 'D12.776.377.715.548.114.254'], ['M01.060.406.448'], ['G12.300'], ['D26.310'], ['E05.290.625', 'E05.337.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['D20.215.894.899.404'], ['B04.820.480.937.600.650.500.500'], ['D20.215.894.899... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Radical hysterectomy. Operative complications]. | The Authors carried out a retrospective examination of data relating to 241 patients undergoing radical hysterectomy with pelvic lymphadenectomy between 1970 and 1991. The basic aim of the study was to identify and quantify complications correlated to radical hysterectomy using the Wertheim-Meigs method. Surgery was pe... | ['Adult', 'Aged', 'Female', 'Humans', 'Hysterectomy', 'Middle Aged', 'Morbidity', 'Retrospective Studies'] | 8,139,784 | [['M01.060.116'], ['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.950.300.399'], ['M01.060.116.630'], ['E05.318.308.985.525', 'N01.224.935.597', 'N06.850.505.400.975.525', 'N06.850.520.308.985.525'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.7... | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Changing my perspective: How the development of emergency medicine in Sri Lanka can inform the Australasian experience. | When compared to an Australasian ED, the two major differences in the emergency medicine practice at Teaching Hospital Karapitiya are which patients are selected at triage and how those selected present. These differences have caused me to reflect on emergency medicine practice in Australasia and wonder if this practic... | ['Australasia', 'Emergency Medicine', 'Humans', 'Sri Lanka'] | 27,457,187 | [['Z01.678.100'], ['H02.403.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.245.840', 'Z01.639.520.875']] | ['Geographicals [Z]', 'Disciplines and Occupations [H]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 |
Remote ischemic perconditioning attenuates acute inflammation of experimental musculocutaneous flaps following ischemia-reperfusion injury. | BACKGROUND: In free flap reconstruction and replantation surgery, prolonged ischemia time may lead to flap or replantation failure. The aim of the study was to investigate the effects of hypothermic flap ischemia or remote ischemic perconditioning (RIPER) during normothermic ischemia on acute inflammation of musculocut... | ['Acute Disease', 'Animals', 'Disease Models, Animal', 'Female', 'Hypothermia, Induced', 'Inflammation', 'Ischemia', 'Ischemic Preconditioning', 'Myocutaneous Flap', 'Reperfusion Injury', 'Superficial Back Muscles', 'Swine'] | 27,062,299 | [['C23.550.291.125'], ['B01.050'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['E02.258.750'], ['C23.550.470'], ['C23.550.513'], ['E02.592', 'E05.516'], ['A10.850.710.625', 'E07.862.710.625'], ['C14.907.725', 'C23.550.767.877'], ['A02.633.567.175.875'], ['B01.050.150.900.649.313.500.880']] | ['Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Overview of the Canadian pediatric end-stage renal disease database. | BACKGROUND: Performing clinical research among pediatric end-stage renal disease patients is challenging. Barriers to successful initiation and completion of clinical research projects include small sample sizes and resultant limited statistical power and lack of longitudinal follow-up for hard clinical end-points in m... | ['Adolescent', 'Canada', 'Child', 'Child, Preschool', 'Data Collection', 'Databases, Factual', 'Female', 'Follow-Up Studies', 'Hospital Mortality', 'Humans', 'Incidence', 'Infant', 'Kidney Failure, Chronic', 'Male', 'Patient Discharge', 'Registries', 'Risk Factors', 'Socioeconomic Factors', 'Treatment Outcome', 'Young ... | 20,796,306 | [['M01.060.057'], ['Z01.107.567.176'], ['M01.060.406'], ['M01.060.406.448'], ['E05.318.308', 'L01.399.250', 'N05.715.360.300', 'N06.850.520.308'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['E05.318.308.985.550.400', 'N... | ['Named Groups [M]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
Large-scale identification of proteins expressed in mouse embryonic stem cells. | A protein subset expressed in the mouse embryonic stem (ES) cell line, E14-1, was characterized by mass spectrometry-based protein identification technology and data analysis. In total, 1790 proteins including 365 potential nuclear and 260 membrane proteins were identified from tryptic digests of total cell lysates. Th... | ['Animals', 'Cell Line', 'Embryo, Mammalian', 'Gene Expression Regulation', 'Humans', 'Mass Spectrometry', 'Mice', 'Molecular Sequence Data', 'Protein Array Analysis', 'Protein Processing, Post-Translational', 'Proteome', 'Stem Cells', 'Transcription Factors'] | 15,742,316 | [['B01.050'], ['A11.251.210'], ['A16.254'], ['G05.308'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.196.566'], ['B01.050.150.900.649.313.992.635.505.500'], ['L01.453.245.667'], ['E05.588.570.700', 'E05.601.680'], ['G02.111.660.871.790.600', 'G02.111.691.600', 'G03.734.871.790.600', 'G05.308.670.600'], ['D12... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Bile duct leakage after laparoscopic cholecystectomy diagnosed by radioisotopic scanning. | Laparoscopic cholecystectomy is fast becoming the procedure of choice for removal of the gallbladder. It offers advantages over traditional cholecystectomy with shorter hospital stays, less postoperative pain, and lowered hospital costs. Laparoscopic cholecystectomy has been shown to be a safe procedure when performed ... | ['Adult', 'Cholecystectomy, Laparoscopic', 'Contrast Media', 'Cystic Duct', 'Extravasation of Diagnostic and Therapeutic Materials', 'Female', 'Humans', 'Imino Acids', 'Organotechnetium Compounds', 'Peritonitis', 'Radionuclide Imaging', 'Technetium'] | 8,482,028 | [['M01.060.116'], ['E04.210.120.172.140', 'E04.502.250.520.160'], ['D27.505.259.500', 'D27.720.259'], ['A03.159.183.079.450'], ['C23.550.340', 'C26.371'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.241.081.583', 'D02.491.485', 'D12.125.072.401'], ['D02.691.825'], ['C01.463.600', 'C06.844.640'], ['E01.370.35... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Structure determination of an integral membrane protein at room temperature from crystals in situ. | The structure determination of an integral membrane protein using synchrotron X-ray diffraction data collected at room temperature directly in vapour-diffusion crystallization plates (in situ) is demonstrated. Exposing the crystals in situ eliminates manual sample handling and, since it is performed at room temperature... | ['Bacterial Proteins', 'Crystallography, X-Ray', 'Haemophilus influenzae', 'Membrane Proteins', 'Models, Molecular', 'Protein Conformation', 'Temperature'] | 26,057,664 | [['D12.776.097'], ['E05.196.309.742.225'], ['B03.440.450.600.450.330', 'B03.660.250.550.290.330'], ['D12.776.543'], ['E05.599.595'], ['G02.111.570.820.709'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.150.450', 'N06.230.300.100.725.710']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
End-User Input into the Design and Validation of a Synthetic Thoracoscopic Esophageal Atresia/Tracheo-Esophageal Fistula Simulator. | Introduction: Thoracoscopic repair of esophageal atresia and tracheo-esophageal fistula (EA/TEF) is challenging. We addressed this by designing a fully synthetic simulator of the procedure and described the design process and how its content validity was assessed. Methods: An iterative design and assessment of content ... | ['Computer Simulation', 'Esophageal Atresia', 'Female', 'Humans', 'Infant, Newborn', 'Male', 'Surveys and Questionnaires', 'Thoracoscopy', 'Tracheoesophageal Fistula'] | 32,348,697 | [['L01.224.160'], ['C06.198.330', 'C06.405.117.260', 'C16.131.314.330'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980'], ['E01.370.388.250.840', 'E04.502.250.840', 'E04.928.752'], ['C06.267.250.725', 'C06.405.117.367.725', 'C08.702... | ['Information Science [L]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
A PET activation study of dynamic mechanical allodynia in patients with mononeuropathy. | The objective of this study was to investigate the central processing of dynamic mechanical allodynia in patients with mononeuropathy. Regional cerebral blood flow, as an indicator of neuronal activity, was measured with positron emission tomography. Paired comparisons were made between three different states; rest, al... | ['Adult', 'Analysis of Variance', 'Brain', 'Cerebrovascular Circulation', 'Female', 'Humans', 'Leg', 'Male', 'Middle Aged', 'Mononeuropathies', 'Pain Measurement', 'Physical Stimulation', 'Somatosensory Cortex', 'Tomography, Emission-Computed'] | 10,568,854 | [['M01.060.116'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['A08.186.211'], ['G09.330.100.159'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A01.378.610.500'], ['M01.060.116.630'], ['C10.668.829.500'], ['E01.370.600.550.324'], ['E05.723'], ['A08.186.211.200.885.287.500.670.675', 'A08.18... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Effect of dilution rate on lipopolysaccharide and serum resistance of Neisseria gonorrhoeae grown in continuous culture. | Growth of Neisseria gonorrhoeae strain FA171 in continuous culture under glucose-limiting conditions resulted in a growth-rate-dependent change in the lipopolysaccharide (LPS). The evidence for this change is an alteration in the mobility of purified alkali-treated LPS on sodium dodecyl sulfate-polyacrylamide gels and ... | ['Alkanes', 'Bacterial Proteins', 'Bacteriological Techniques', 'Blood Bactericidal Activity', 'Carbohydrates', 'Humans', 'Lipopolysaccharides', 'Neisseria gonorrhoeae', 'Surface Properties'] | 6,408,006 | [['D02.455.326.146'], ['D12.776.097'], ['E01.370.225.875.150', 'E05.200.875.150'], ['G09.188.100', 'G12.450.564.204'], ['D09'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D09.400.500', 'D09.698.718.450', 'D10.494', 'D23.050.161.616.525', 'D23.946.123.329.500'], ['B03.440.400.425.550.550.474', 'B03.660.075.525.5... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Fatty and hemorrhagic liver and kidney syndrome in breeding hens caused by aflatoxin B1 and heat stress in the Sudan. | Fatty liver in animals is commonly associated with toxic or nutritional disease. In tropical Africa, fatty liver in poultry is of considerable economic importance. However, it's occurrence and association with renal damage have not yet been reported. We now report the effects of hemorrhagic and fatty hepatorenal syndro... | ['Aflatoxin B1', 'Aflatoxins', 'Animal Feed', 'Animals', 'Chickens', 'Diet', 'Fatty Liver', 'Female', 'Heat Exhaustion', 'Kidney Diseases', 'Poultry Diseases', 'Sudan'] | 3,111,074 | [['D03.383.663.283.119.075', 'D03.633.100.150.119.075', 'D23.946.587.142.075'], ['D03.383.663.283.119', 'D03.633.100.150.119', 'D23.946.587.142'], ['G07.203.300.300.100', 'J02.500.300.100'], ['B01.050'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['G07.203.650.240'], ['C06.552.241'], ['C26.522.250'... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 |
Urgent operation for acquired ventricular septal defect. | Recent experience suggests that ventricular septal defect (VSD) secondary to myocardial infarction constitutes an indication for urgent operation. Acquired VSD at St. Thomas Hospital, Nashville, was reviewed to substantiate the obsolescence of protracted medical therapy designed to allow a late, technically less demand... | ['Aged', 'Female', 'Heart Septal Defects, Ventricular', 'Humans', 'Male', 'Middle Aged', 'Mortality', 'Myocardial Infarction'] | 7,082,062 | [['M01.060.116.100'], ['C14.240.400.560.540', 'C14.280.400.560.540', 'C16.131.240.400.560.540'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.308.985.550', 'N01.224.935.698', 'N06.850.505.400.975.550', 'N06.850.520.308.985.550'], ['C14.280.647.500', 'C14.907.585.500', 'C23.550.513.355... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Synthesis and structure-activity relationships of phenylenebis(methylene)-linked bis-tetraazamacrocycles that inhibit HIV replication. Effects of macrocyclic ring size and substituents on the aromatic linker. | We have previously described the potent and selective inhibition of several strains of human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) by JM2763, an n-propyl-linked dimer of the 1,4,8,11-tetraazamacrocyclic (cyclam) ring system. Upon further investigation, we have also found that incorporating an aromati... | ['Antiviral Agents', 'Cells, Cultured', 'HIV-1', 'HIV-2', 'Heterocyclic Compounds', 'In Vitro Techniques', 'Structure-Activity Relationship', 'Virus Replication'] | 7,830,280 | [['D27.505.954.122.388'], ['A11.251'], ['B04.820.650.589.650.350.400'], ['B04.820.650.589.650.350.410'], ['D03'], ['E05.481'], ['G02.111.830', 'G07.690.773.997'], ['G06.920.925']] | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Body fat free mass is associated with the serum metabolite profile in a population-based study. | OBJECTIVE: To characterise the influence of the fat free mass on the metabolite profile in serum samples from participants of the population-based KORA (Cooperative Health Research in the Region of Augsburg) S4 study.SUBJECTS AND METHODS: Analyses were based on metabolite profile from 965 participants of the S4 and 890... | ['Adipose Tissue', 'Aged', 'Blood Chemical Analysis', 'Body Composition', 'Humans', 'Metabolomics', 'Middle Aged'] | 22,761,945 | [['A10.165.114'], ['M01.060.116.100'], ['E01.370.225.124.100', 'E05.200.124.100'], ['G02.111.130', 'G03.180', 'G07.100.049'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H01.158.201.586', 'H01.158.273.180.599', 'H01.181.122.638'], ['M01.060.116.630']] | ['Anatomy [A]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Hyperthermia increases the metastatic potential of murine melanoma. | Hyperthermia, either alone or combined with radio-, immuno- or chemotherapy, can control tumor growth, but its effect on metastasis is still controversial. In the present study, we investigated the influence of hyperthermia on the metastatic potential of B16-F10 murine melanoma cells. Incubation of melanoma cells at 43... | ['Animals', 'Female', 'Hyperthermia, Induced', 'Melanoma, Experimental', 'Mice'] | 9,361,722 | [['B01.050'], ['E02.565'], ['C04.557.465.625.650.510.525', 'C04.557.580.625.650.510.525', 'C04.557.665.510.525', 'C04.619.600', 'E05.598.500.496.937'], ['B01.050.150.900.649.313.992.635.505.500']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Spatial proximity and similarity of the epigenetic state of genome domains. | Recent studies demonstrate that the organization of the chromatin within the nuclear space might play a crucial role in the regulation of gene expression. The ongoing progress in determination of the 3D structure of the nuclear chromatin allows one to study correlations between spatial proximity of genome domains and t... | ['Cell Nucleus', 'Chromatin', 'Chromosome Mapping', 'Chromosomes, Human', 'Epigenomics', 'Gene Expression Regulation', 'Genome, Human', 'Histones', 'Humans', 'Nuclear Matrix', 'RNA', 'Trans-Splicing', 'Transcription, Genetic'] | 22,496,774 | [['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['A11.284.430.106.279.345.190.160.180', 'D12.776.664.224', 'G05.360.160.180'], ['E05.393.183'], ['A11.284.187.520.300', 'G05.360.162.520.300'], ['H01.158.273.180.350.074', 'H01.158.273.343.350.042'], ['G05.308'], ['G05.360.340.350'], ['D12.776.157.687.485', 'D12.776.... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Development of motilin receptors and of motilin- and erythromycin-induced contractility in rabbits. | The development of the motilin receptor was studied through contraction and binding studies of groups of three rabbits aged between 2 and 289 days. The contractility of small intestinal smooth muscle strips was measured isotonically. The aborally decreasing gradient in response to motilin, known to exist in adult rabbi... | ['Acetylcholine', 'Animals', 'Erythromycin', 'Gastrointestinal Motility', 'In Vitro Techniques', 'Intestine, Small', 'Motilin', 'Muscle Contraction', 'Muscle Development', 'Muscle, Smooth', 'Organ Size', 'Pyloric Antrum', 'Rabbits', 'Receptors, Gastrointestinal Hormone', 'Receptors, Neuropeptide', 'Regression Analysis'... | 2,379,773 | [['D02.092.211.111'], ['B01.050'], ['D02.540.576.500.992'], ['G10.261.360'], ['E05.481'], ['A03.556.124.684'], ['D06.472.317.525', 'D06.472.699.500', 'D12.644.400.470', 'D12.644.548.500', 'D12.776.631.650.463'], ['G11.427.494'], ['G07.345.500.325.377.625.590', 'G11.427.578.590'], ['A02.633.570', 'A10.690.467'], ['E01.3... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Sex education in Halton secondary schools. | One teacher from each of the secondary schools and four special schools in Halton district completed a questionnaire in a semi-structured interview on sex education in their schools. The results showed that a variety of programmes took place but frequently teachers did not feel adequately prepared to teach this vital b... | ['Acquired Immunodeficiency Syndrome', 'Adolescent', 'Attitude to Health', 'Curriculum', 'Humans', 'School Health Services', 'Sex Education', 'Teaching'] | 2,753,719 | [['C01.221.250.875.040', 'C01.221.812.640.400.040', 'C01.778.640.400.040', 'C01.925.782.815.616.400.040', 'C01.925.813.400.040', 'C01.925.839.040', 'C20.673.480.040'], ['M01.060.057'], ['F01.100.150', 'N05.300.150'], ['I02.158'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N02.421.726.809'], ['F04.096.837.500', ... | ['Diseases [C]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Redox cycling of 9,10-phenanthrenequinone activates epidermal growth factor receptor signaling through S-oxidation of protein tyrosine phosphatase 1B. | 9,10-Phenanthrenequinone (9,10-PQ) is a polycyclic aromatic hydrocarbon quinone contaminated in diesel exhaust particles and particulate matter 2.5. It is an efficient electron acceptor that induces redox cycling with electron donors, resulting in excessive reactive oxygen species and oxidized protein production in cel... | ['Cells, Cultured', 'ErbB Receptors', 'Humans', 'MAP Kinase Signaling System', 'Oxidation-Reduction', 'Phenanthrenes', 'Protein Tyrosine Phosphatase, Non-Receptor Type 1', 'Reactive Oxygen Species', 'Signal Transduction'] | 32,493,877 | [['A11.251'], ['D08.811.913.696.620.682.725.400.009', 'D12.776.543.750.630.009', 'D12.776.543.750.750.400.074'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.111.820.560', 'G03.493.560', 'G04.835.560'], ['G02.700', 'G03.295.531'], ['D02.455.426.559.847.723', 'D04.615.723'], ['D08.811.277.352.650.775.300.100',... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Genome-wide inference of ancestral recombination graphs. | The complex correlation structure of a collection of orthologous DNA sequences is uniquely captured by the "ancestral recombination graph" (ARG), a complete record of coalescence and recombination events in the history of the sample. However, existing methods for ARG inference are computationally intensive, highly appr... | ['Algorithms', 'Computer Simulation', 'Evolution, Molecular', 'Genome, Human', 'Humans', 'Markov Chains', 'Models, Genetic', 'Monte Carlo Method', 'Recombination, Genetic', 'Selection, Genetic'] | 24,831,947 | [['G17.035', 'L01.224.050'], ['L01.224.160'], ['G05.045.250', 'G16.075.250'], ['G05.360.340.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.600.500', 'E05.318.740.996.500', 'G17.830.500', 'N05.715.360.750.625.500', 'N05.715.360.750.770.500', 'N06.850.520.830.600.500', 'N06.850.520.830.996.500'], [... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
The reliability and validity of the Korean version of the Epworth sleepiness scale. | OBJECTIVE: The Epworth sleepiness scale (ESS) is widely used to measure the subject's average sleep propensity across those different situations in daily life, particularly in patients with sleep-disordered breathing. The purposes of this study were to test the hypothesis that the Korean version of the ESS (KESS) is va... | ['Adult', 'Body Mass Index', 'Cross-Cultural Comparison', 'Disorders of Excessive Somnolence', 'Female', 'Humans', 'Korea', 'Male', 'Middle Aged', 'Polysomnography', 'Psychometrics', 'Reference Values', 'Reproducibility of Results', 'Sleep Apnea, Obstructive', 'Snoring', 'Surveys and Questionnaires', 'Translating'] | 20,358,406 | [['M01.060.116'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['I01.076.201.450.281', 'I01.880.853.100.257'], ['C10.886.425.800.200', 'F03.870.400.800.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.474.557', 'Z01.586.407'], ['M01.060.116.630'], ['E01.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Geographicals [Z]', 'Information Science [L]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
XRCC1 Arg194TRp and Arg399Gln Polymorphisms and Risk of Non-Hodgkin Lymphoma in a Romanian Population. | XRCC1 polymorphisms may alter the individual’s capacity to repair DNA damages and may increase the risk for developing different types of cancer, including Non-Hodgkin Lymphoma (NHL). The purpose of our study was to investigate the association between XRCC1 Arg194Trp and Arg399Gln polymorphisms and risk of NHL, in a ca... | ['Case-Control Studies', 'DNA Repair', 'DNA-Binding Proteins', 'Female', 'Genetic Predisposition to Disease', 'Genotype', 'Humans', 'Lymphoma, Non-Hodgkin', 'Male', 'Middle Aged', 'Polymorphism, Genetic', 'Risk Factors', 'Romania', 'X-ray Repair Cross Complementing Protein 1'] | 30,148,297 | [['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['G02.111.222', 'G05.219'], ['D12.776.260'], ['C23.550.291.687.500', 'G05.380.355'], ['G05.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.386.480', 'C15.604.515.569.480', 'C20.683.515.761.480'], ['M01.060.116.630'], ['G05... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
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