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Elongation factor Ts directly facilitates the formation and disassembly of the Escherichia coli elongation factor Tu·GTP·aminoacyl-tRNA ternary complex. | BACKGROUND: Aminoacyl-tRNA (aa-tRNA) enters the ribosome in a ternary complex with the G-protein elongation factor Tu (EF-Tu) and GTP.RESULTS: EF-Tu·GTP·aa-tRNA ternary complex formation and decay rates are accelerated in the presence of the nucleotide exchange factor elongation factor Ts (EF-Ts).CONCLUSION: EF-Ts dire... | ['Binding Sites', 'Escherichia coli', 'Escherichia coli Proteins', 'Guanosine Triphosphate', 'Kinetics', 'Models, Molecular', 'Peptide Elongation Factor Tu', 'Peptide Elongation Factors', 'Protein Binding', 'Protein Multimerization', 'Protein Stability', 'Protein Structure, Quaternary', 'Protein Structure, Secondary', ... | 23,539,628 | [['G02.111.570.120'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D12.776.097.275'], ['D03.633.100.759.646.454.504', 'D13.695.667.454.504', 'D13.695.827.426.504'], ['G01.374.661', 'G02.111.490'], ['E05.599.595'], ['D08.811.277.040.330.300.100.700', 'D12.776.157.325.150.700', 'D12.776.835.700.350.700'], ['... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Clostridium difficile typhlitis associated with cecal mucosal hyperplasia in Syrian hamsters. | A sudden increase in mortality occurred in a closed breeding colony of Syrian hamsters (Mesocricetus auratus). The colony consisted of approximately 40 hamsters, 8 of which were affected. Four adult males died suddenly. One pregnant female and one weanling died after having been observed as depressed for 1 day and 2 we... | ['Animals', 'Bacterial Proteins', 'Bacterial Toxins', 'Cecum', 'Clostridioides difficile', 'Cricetinae', 'Cytotoxins', 'Enterocolitis, Pseudomembranous', 'Female', 'Hyperplasia', 'Intestinal Mucosa', 'Male', 'Mesocricetus', 'Pregnancy'] | 1,667,196 | [['B01.050'], ['D12.776.097'], ['D23.946.123'], ['A03.556.124.526.209', 'A03.556.249.249.209'], ['B03.353.625.657.500'], ['B01.050.150.900.649.313.992.635.075.250'], ['D27.888.569.213'], ['C01.150.252.410.222.310', 'C06.405.205.596.800', 'C06.405.469.363.800'], ['C23.550.444'], ['A03.556.124.369', 'A10.615.550.444'], [... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Establishment of a leptospirosis model in guinea pigs using an epicutaneous inoculations route. | BACKGROUND: Leptospires are presumed to enter their host via small abrasions or breaches of the skin. The intraperitoneal route, although commonly used in guinea pig and hamster models of leptospirosis, does not reflect conditions encountered during natural infection. The aim of this study is to develop a novel leptosp... | ['Animal Structures', 'Animals', 'Disease Models, Animal', 'Guinea Pigs', 'Leptospira interrogans', 'Leptospirosis', 'Male', 'Microscopy', 'Skin'] | 22,273,178 | [['A13'], ['B01.050'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['B01.050.150.900.649.313.992.550'], ['B03.440.400.425.475.475.400', 'B03.851.475.475.400'], ['C01.150.252.400.794.511'], ['E01.370.350.515', 'E05.595', 'H01.671.617.562'], ['A17.815']] | ['Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Asparagine transport and the induction of ornithine decarboxylase in H-35 rat hepatoma cells. | A number of amino acids, most noticeably asparagine, were capable of inducing ornithine decarboxylase in H-35 rat hepatoma cells. The effective amino acids were all neutral and were substrates of the Na+-dependent transport systems A, ASC and N. Transport inhibitor studies indicated that there was an excellent correlat... | ['Amino Acids', 'Animals', 'Asparagine', 'Biological Transport', 'Enzyme Induction', 'Hydrogen-Ion Concentration', 'Liver Neoplasms, Experimental', 'Ornithine Decarboxylase', 'Rats', 'Tumor Cells, Cultured'] | 3,453,089 | [['D12.125'], ['B01.050'], ['D12.125.068.060', 'D12.125.095.165', 'D12.125.154.049'], ['G03.143'], ['G05.308.320.200'], ['G02.300'], ['C04.588.274.623.460', 'C04.619.540', 'C06.301.623.460', 'C06.552.697.580', 'E05.598.500.496.750'], ['D08.811.520.224.125.425'], ['B01.050.150.900.649.313.992.635.505.700'], ['A11.251.86... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Interaction of poliovirus polypeptide 3CDpro with the 5' and 3' termini of the poliovirus genome. Identification of viral and cellular cofactors needed for efficient binding. | Poliovirus proteinase 3CDpro by itself is not an RNA-binding protein. Two cellular proteins have been purified from HeLa cells (p50 and p36) which interact with purified 3CDpro but only p36-3CDpro bind to the 5'-terminal 110 nucleotides of polioviral RNA genome, an RNA segment whose secondary structure resembles a clov... | ['Base Sequence', 'Cysteine Endopeptidases', 'Genome, Viral', 'HeLa Cells', 'Humans', 'Models, Genetic', 'Molecular Sequence Data', 'Nucleic Acid Conformation', 'Peptide Elongation Factor 1', 'Peptide Elongation Factors', 'Peptide Fragments', 'Poliovirus', 'Protein Binding', 'RNA, Viral', 'RNA-Binding Proteins', 'Seque... | 7,929,441 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D08.811.277.656.262.500', 'D08.811.277.656.300.200'], ['G05.360.340.358.840'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.395.397'], ['L01.453.245.667'], ['G02.111.570.820.486', '... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
OCT skin image enhancement through attenuation compensation. | The enhancement of optical coherence tomography (OCT) skin images can help dermatologists investigate the morphologic information of the images more effectively. In this paper, we propose an enhancement algorithm with the stages that includes speckle reduction, skin layer detection, and attenuation compensation. A weig... | ['Adult', 'Algorithms', 'Dermis', 'Epidermis', 'Female', 'Humans', 'Image Enhancement', 'Male', 'Signal-To-Noise Ratio', 'Skin', 'Tomography, Optical Coherence'] | 22,858,930 | [['M01.060.116'], ['G17.035', 'L01.224.050'], ['A17.815.180'], ['A10.272.497', 'A17.815.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.600.350', 'L01.224.308.380'], ['E05.318.370.800.875', 'E05.318.740.872.875', 'G17.800.500', 'N05.715.360.325.700.840', 'N05.715.360.750.725.750', 'N06.850.520.445... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
A novel high-performance anion-exchange chromatographic method for the analysis of carrageenans and agars containing 3,6-anhydrogalactose. | A novel method has been developed to determine the sugar composition of 3,6-anhydrogalactose-containing polysaccharides, such as carrageenan and agar. The method is based on reductive hydrolysis with a methylmorpholine-borane complex in the presence of acid and subsequent high-performance anion-exchange chromatography ... | ['Agar', 'Carrageenan', 'Chromatography, Gas', 'Chromatography, High Pressure Liquid', 'Chromatography, Ion Exchange', 'Evaluation Studies as Topic', 'Galactose', 'Hydrolysis', 'Magnetic Resonance Spectroscopy', 'Monosaccharides', 'Oxidation-Reduction', 'Polysaccharides', 'Reproducibility of Results', 'Seaweed'] | 10,075,810 | [['D09.698.360.041'], ['D09.698.152'], ['E05.196.181.349'], ['E05.196.181.400.300'], ['E05.196.181.400.383'], ['E05.337', 'N05.715.360.335'], ['D09.947.875.359.377'], ['G02.380'], ['E05.196.867.519'], ['D09.947.875'], ['G02.700', 'G03.295.531'], ['D09.698'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N0... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Rhodium-catalyzed substitution reaction of aryl fluorides with disulfides: p-orientation in the polyarylthiolation of polyfluorobenzenes. | In the presence of a catalytic amount of RhH(PPh3)4 and 1,2-bis(diphenylphosphino)benzene, an aromatic fluoride, an organic disulfide (0.5 equiv), and triphenylphosphine (0.5 equiv) reacted in refluxing chlorobenzene to give an aryl sulfide in high yield. Since triphenylphosphine trapped fluoride atoms forming phosphin... | ['Catalysis', 'Disulfides', 'Fluorobenzenes', 'Organophosphorus Compounds', 'Rhodium', 'Sulfhydryl Compounds'] | 18,722,437 | [['G02.130'], ['D01.248.497.158.874.390', 'D01.875.350.850.150', 'D02.886.520.150'], ['D02.455.426.559.389.358', 'D02.455.526.510.432'], ['D02.705'], ['D01.268.556.793', 'D01.268.956.781', 'D01.552.544.793'], ['D02.886.489']] | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effect of renal transplantation on biomarkers of inflammation and oxidative stress in end-stage renal disease patients. | BACKGROUND: Chronic kidney disease patients have a high prevalence of inflammation and oxidative stress, and this has been associated with the excess cardiovascular morbidity and mortality observed in this population. Because maintenance hemodialysis is ineffective in controlling these factors, we hypothesized that res... | ['Adult', 'Biomarkers', 'Female', 'Humans', 'Inflammation', 'Kidney Failure, Chronic', 'Kidney Transplantation', 'Male', 'Middle Aged', 'Oxidative Stress'] | 15,849,543 | [['M01.060.116'], ['D23.101'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.470'], ['C12.777.419.780.750.500', 'C13.351.968.419.780.750.500'], ['E02.870.500', 'E04.936.450.485', 'E04.950.774.400'], ['M01.060.116.630'], ['G03.673', 'G07.775.750']] | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Bioinformatics and microarray analysis of microRNA expression profiles of murine embryonic stem cells, neural stem cells induced from ESCs and isolated from E8.5 mouse neural tube. | To better understand whether microRNAs (miRNAs) are involved in the self-renewal of stem cells and fate determination of neural stem cells and to identify the miRNA expression patterns of different neural stem cells (NSC) in vitro and in vivo, we examined miRNA expression profiles of murine embryonic stem cells (ESC), ... | ['Animals', 'Cell Differentiation', 'Computational Biology', 'Embryo, Mammalian', 'Embryonic Stem Cells', 'Flow Cytometry', 'Gene Expression', 'Gene Expression Profiling', 'Intermediate Filament Proteins', 'Mice', 'MicroRNAs', 'Microarray Analysis', 'Microscopy, Confocal', 'Nerve Tissue Proteins', 'Nestin', 'Neural Tub... | 19,660,235 | [['B01.050'], ['G04.152'], ['H01.158.273.180', 'L01.313.124'], ['A16.254'], ['A11.872.700.250'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.200.500.386.350', 'E05.242.363.342', 'E05.242.386.350'], ['G05.297'], ['E05.393.332'], ['D05.750.078.593', 'D... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Information Science [L]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Competitive season of triathlon does not alter bone metabolism and bone mineral status in male triathletes. | This longitudinal study evaluated the effects of a triathlon season on bone metabolism and hormonal status. Seven male competitive triathletes (mean age 19.3 years, range 18 - 20) with 5.0 +/- 0.3 years of competition experience were tested twice during the season: at the beginning of training and 32 weeks later. Total... | ['Absorptiometry, Photon', 'Adolescent', 'Adult', 'Alkaline Phosphatase', 'Bicycling', 'Bone Density', 'Bone Remodeling', 'Bone and Bones', 'Collagen', 'Collagen Type I', 'Enzyme-Linked Immunosorbent Assay', 'Exercise Test', 'Hormones', 'Humans', 'Longitudinal Studies', 'Male', 'Osteocalcin', 'Peptides', 'Running', 'St... | 15,088,249 | [['E01.370.350.700.024', 'E05.196.712.224.187'], ['M01.060.057'], ['M01.060.116'], ['D08.811.277.352.650.035'], ['I03.450.642.845.140'], ['G11.427.100'], ['G11.427.213', 'G16.762.150'], ['A02.835.232', 'A10.165.265'], ['D05.750.078.280', 'D12.776.860.300.250'], ['D05.750.078.280.300.100', 'D12.776.860.300.250.300.100']... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
How important are community characteristics in influencing children?s nutritional status? Evidence from Malawi population-based household and community surveys. | Using the 2004 data from the Malawi Integrated Household Survey and the Malawi Community Survey, this study investigates the influence of community characteristics on stunting among children under five years of age in a rural context. Multilevel logistic regression modelling on 4284 children with stunting as the depend... | ['Child Health', 'Child, Preschool', 'Female', 'Humans', 'Malawi', 'Male', 'Malnutrition', 'Nutrition Surveys', 'Nutritional Status', 'Residence Characteristics'] | 25,305,476 | [['N01.400.225'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.058.290.175.500'], ['C18.654.521'], ['E05.318.308.980.485', 'N05.715.360.300.800.469', 'N06.850.505.616', 'N06.850.520.308.980.469'], ['G07.203.650.650', 'N01.224.425.525'], ['N01.224.791', 'N06.850.505.400.800']] | ['Health Care [N]', 'Named Groups [M]', 'Organisms [B]', 'Geographicals [Z]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
A prospective analysis of endoloops and endostaples for closing the stump of the appendix in children. | AIM: The aim of this study was to compare endoloops and endostaples for closing the stump of the appendix during laparoscopic appendectomy (LA) for uncomplicated appendicitis in children.METHODS: All LA performed for appendicitis from 2005 to 2009 were analyzed prospectively. Cases of complicated appendicitis such as p... | ['Adolescent', 'Appendectomy', 'Appendicitis', 'Child', 'Child, Preschool', 'Cost-Benefit Analysis', 'Female', 'Humans', 'Laparoscopy', 'Male', 'Prospective Studies', 'Retrospective Studies', 'Suture Techniques', 'Sutures', 'Treatment Outcome'] | 21,214,418 | [['M01.060.057'], ['E04.210.078'], ['C01.463.099', 'C06.405.205.099', 'C06.405.469.110.207'], ['M01.060.406'], ['M01.060.406.448'], ['N03.219.151.125'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.388.250.520', 'E04.502.250.520'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.45... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Multiphoton microscopy and fluorescence lifetime imaging provide a novel method in studying drug distribution and metabolism in the rat liver in vivo. | Multiphoton microscopy has been shown to be a useful tool in studying drug distribution in biological tissues. In addition, fluorescence lifetime imaging provides information about the structure and dynamics of fluorophores based on their fluorescence lifetimes. Fluorescein, a commonly used fluorescent probe, is metabo... | ['Acinar Cells', 'Animals', 'Bile', 'Fluoresceins', 'Histocytochemistry', 'Liver', 'Male', 'Microscopy, Fluorescence, Multiphoton', 'Models, Chemical', 'Rats', 'Rats, Wistar', 'Tissue Distribution'] | 21,895,325 | [['A11.031'], ['B01.050'], ['A12.200.087'], ['D02.455.426.779.347', 'D03.633.300.953.275', 'D04.711.347'], ['E01.370.225.500.607', 'E01.370.225.750.551', 'E05.200.500.607', 'E05.200.750.551', 'H01.158.100.656.234', 'H01.158.201.344', 'H01.181.122.573'], ['A03.620'], ['E01.370.350.515.458.500', 'E01.370.350.515.717.250'... | ['Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Technical aspects of unilateral dual kidney transplantation from expanded criteria donors: experience of 100 patients. | One option for using organs from donors with a suboptimal nephron mass, e.g. expanded criteria donors (ECD) kidneys, is dual kidney transplantation (DKT). In adult recipients, DKT can be carried out by several techniques, but the unilateral placement of both kidneys (UDKT) offers the advantages of single surgical acces... | ['Aged', 'Cohort Studies', 'Feasibility Studies', 'Female', 'Follow-Up Studies', 'Graft Survival', 'Humans', 'Incidence', 'Kidney', 'Kidney Transplantation', 'Male', 'Middle Aged', 'Renal Veins', 'Tissue Donors', 'Transplantation, Heterotopic', 'Vena Cava, Inferior', 'Venous Thrombosis'] | 20,636,454 | [['M01.060.116.100'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E05.318.372.550', 'E05.337.675', 'N05.715.360.330.550', 'N06.850.520.450.550'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['G12.875.545.340'], ['B01.050.150.900.649.313... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Fe(III) promoted LAS (linear alkylbenzenesulfonate) removal from waters. | The mechanisms of the interactions between Fe(III) aquacomplexes and surfactants were investigated; three alkylbenzenzsulfonates, two surfactants (octylbenzenesulfonate (OBS) and dodecylbenzenesulfonate (DBS)), and a shorter derivative (ethylbenzenesulfonate (EBS)) were studied. The results with OBS show evidence for t... | ['Alkanesulfonic Acids', 'Chromatography, High Pressure Liquid', 'Ferric Compounds', 'Ferrous Compounds', 'Molecular Structure', 'Oxidation-Reduction', 'Surface-Active Agents', 'Water Pollutants, Chemical', 'Water Purification'] | 18,359,058 | [['D02.455.326.146.100', 'D02.886.645.600.055'], ['E05.196.181.400.300'], ['D01.490.100'], ['D01.490.200'], ['G02.111.570', 'G02.466'], ['G02.700', 'G03.295.531'], ['D27.720.877'], ['D27.888.284.903.655'], ['N06.850.780.200.800.800.900.900', 'N06.850.860.510.900.900']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Use of prevention and prevention plus weight management guidelines for youth with developmental disabilities living in group homes. | INTRODUCTION: Prevention and Prevention Plus strategies for weight management were implemented for youth with developmental disabilities living in community group homes at a Midwestern educational/residential center.METHODS: Caregiver staff were provided with weight management education, a communication tool for youth ... | ['Adolescent', 'Adolescent Behavior', 'Body Mass Index', 'Caregivers', 'Child', 'Child Behavior', 'Developmental Disabilities', 'Diet', 'Female', 'Follow-Up Studies', 'Fruit', 'Group Homes', 'Guidelines as Topic', 'Health Education', 'Humans', 'Male', 'Midwestern United States', 'Obesity', 'Risk Reduction Behavior', 'V... | 23,414,975 | [['M01.060.057'], ['F01.145.022'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['M01.085', 'M01.526.485.200', 'N02.360.200'], ['M01.060.406'], ['F01.145.179'], ['F03.625.421'], ['G07.203.650.240'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Ge... | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
The ciliary-cone sensory cell of anemones and cerianthids. | An ultrastructural study of the tentacles of Stomphia and of Ceriantheopsis has revealed that the so-called 'ciliary-cone sensory cell' consists of a cluster of five to seven apparent receptors rather than just one cell as reported previously. At the center of a cluster is a single cell, whose dendrite bears one cilium... | ['Animals', 'Cilia', 'Cnidaria', 'Dendrites', 'Sea Anemones', 'Sensory Receptor Cells'] | 238,306 | [['B01.050'], ['A11.284.180.165'], ['B01.050.500.308'], ['A08.675.256', 'A11.284.180.225', 'A11.671.240'], ['B01.050.500.308.237.750'], ['A08.675.650.915', 'A08.800.950', 'A11.671.650.915']] | ['Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Flux-based transport enhancement as a plausible unifying mechanism for auxin transport in meristem development. | Plants continuously generate new organs through the activity of populations of stem cells called meristems. The shoot apical meristem initiates leaves, flowers, and lateral meristems in highly ordered, spiralled, or whorled patterns via a process called phyllotaxis. It is commonly accepted that the active transport of ... | ['Cell Polarity', 'Facilitated Diffusion', 'Indoleacetic Acids', 'Membrane Transport Proteins', 'Meristem', 'Models, Biological', 'Plant Physiological Phenomena', 'Protein Transport', 'Signal Transduction'] | 18,974,825 | [['G04.250'], ['G01.154.280', 'G01.202.374', 'G02.196.500', 'G03.143.427'], ['D03.066.288', 'D03.633.100.473.404'], ['D12.776.157.530', 'D12.776.543.585'], ['A18.024.875.875', 'A18.024.937.500', 'A18.400.500'], ['E05.599.395'], ['G15'], ['G03.143.700'], ['G02.111.820', 'G04.835']] | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
CHRONIC PANCREATITIS IN A PATIENT WITH THE p.Asn34Ser HOMOZYGOUS SPINK1 MUTATION--OWN EXPERIENCE. | Chronic pancreatitis (CP) is characterized by progressive damage to the exocrine and endocrine cell structures and pancreatic ducts with subsequent fibrosis of the organ. Patients with no apparent etiological factor are classified as having idiopathic CP (ICP). Genetic studies indicate the importance of mutations in th... | ['Adult', 'Carrier Proteins', 'DNA Mutational Analysis', 'Female', 'Genetic Predisposition to Disease', 'Genotype', 'Humans', 'Mutation', 'Pancreatitis, Chronic', 'Polymorphism, Genetic', 'Trypsin Inhibitor, Kazal Pancreatic'] | 26,958,679 | [['M01.060.116'], ['D12.776.157'], ['E05.393.760.700.300'], ['C23.550.291.687.500', 'G05.380.355'], ['G05.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G05.365.590'], ['C06.689.750.830'], ['G05.365.795'], ['D12.644.822.750.500', 'D12.776.124.050.850', 'D12.776.645.688.500']] | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
pH dependent high transfection efficiency of mouse neuroblastomas using TransFectin. | Mouse neuroblastoma cell lines are often used in lieu of mouse primary neurons in ex vivo experiments, as they provide an easier platform for transfection, compared to the latter. A well-known inherent problem with this strategy is the relatively low transfection efficiency (15-30%) of mouse neuroblastoma cell lines su... | ['Animals', 'Blotting, Western', 'Cations', 'Cell Line, Tumor', 'Flow Cytometry', 'Green Fluorescent Proteins', 'Hydrogen-Ion Concentration', 'Liposomes', 'Mice', 'Neuroblastoma', 'Time Factors', 'Transfection'] | 16,814,394 | [['B01.050'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['D01.248.497.300'], ['A11.251.210.190', 'A11.251.860.180'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.200.500.386.350', 'E05.242.363... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
ERCC4 (XPF) encodes a human nucleotide excision repair protein with eukaryotic recombination homologs. | ERCC4 is an essential human gene in the nucleotide excision repair (NER) pathway, which is responsible for removing UV-C photoproducts and bulky adducts from DNA. Among the NER genes, ERCC4 and ERCC1 are also uniquely involved in removing DNA interstrand cross-linking damage. The ERCC1-ERCC4 heterodimer, like the homol... | ['Amino Acid Sequence', 'Animals', 'Base Sequence', 'CHO Cells', 'Cell Survival', 'Cloning, Molecular', 'Cosmids', 'Cricetinae', 'DNA Damage', 'DNA Repair', 'DNA Repair Enzymes', 'DNA-Binding Proteins', 'Drosophila Proteins', 'Drosophila melanogaster', 'Endonucleases', 'Exons', 'Fungal Proteins', 'Humans', 'Introns', '... | 8,887,684 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A11.251.210.200', 'A11.436.155'], ['G04.346'], ['E05.393.220'], ['G05.360.337.500', 'G05.360.600.250'], ['B01.050.150.900.649.313.992.635.075.250'], ['G05.200'], ['G02.111.222', 'G05.219'], ['D08.811.0... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
The unfolded protein response supports cellular robustness as a broad-spectrum compensatory pathway. | Stress pathways monitor intracellular systems and deploy a range of regulatory mechanisms in response to stress. One of the best-characterized pathways, the unfolded protein response (UPR), is responsible for maintaining endoplasmic reticulum (ER) homeostasis. The highly conserved Ire1 branch regulates hundreds of gene... | ['Alleles', 'Endoplasmic Reticulum', 'Fungal Proteins', 'Gene Deletion', 'Glycosylation', 'Models, Genetic', 'Molecular Conformation', 'Mutation', 'Phenotype', 'Protein Denaturation', 'Protein Folding', 'Signal Transduction', 'Temperature', 'Transcription, Genetic', 'Unfolded Protein Response', 'beta-Galactosidase'] | 22,143,797 | [['G05.360.340.024.340.030'], ['A11.284.430.214.190.875.248'], ['D12.776.354'], ['G05.365.590.762.320', 'G05.558.800.320'], ['G02.111.158.812', 'G02.607.299', 'G03.191.812'], ['E05.599.395.397'], ['G02.111.570.820'], ['G05.365.590'], ['G05.695'], ['G01.154.651.750.500', 'G02.111.688.750.500'], ['G01.154.651', 'G02.111.... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Genital Cancers in Women: Vulvar Cancer. | Vulvar cancer is uncommon, accounting for 0.3% of all new US cancer diagnoses. The majority of cases are squamous cell carcinoma. Malignant melanoma is the second most common type. Other cases are related to chronic inflammatory skin disorders such as lichen sclerosus. Vulvar intraepithelial neoplasia (VIN) is a precur... | ['Carcinoma in Situ', 'Carcinoma, Squamous Cell', 'Chronic Disease', 'Female', 'Humans', 'Neoplasm Staging', 'Papillomavirus Infections', 'Precancerous Conditions', 'Skin Diseases', 'United States', 'Vulvar Neoplasms'] | 26,569,049 | [['C04.557.470.200.240'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['C23.550.291.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.789.625'], ['C01.925.256.650', 'C01.925.928.725'], ['C04.834'], ['C17.800'], ['Z01.107.567.875'], ['C04.588.945.418.968', 'C13.351.500.944.819', 'C13.351.937.418.968']] | ['Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
A multicenter, placebo-controlled study evaluating zolpidem in the treatment of chronic insomnia. | BACKGROUND: Zolpidem is a short-acting, nonbenzodiazepine hypnotic with rapid onset of action. Even though it is not a benzodiazepine, it binds to one of three types of central benzodiazepine receptors, showing selective binding to the type 1 benzodiazepine receptor subtype. Therapeutic hypnotic dosages do not disturb ... | ['Adult', 'Chronic Disease', 'Double-Blind Method', 'Drug Administration Schedule', 'Female', 'Humans', 'Hypnotics and Sedatives', 'Male', 'Middle Aged', 'Placebos', 'Polysomnography', 'Psychomotor Performance', 'Pyridines', 'Sleep', 'Sleep Initiation and Maintenance Disorders', 'Zolpidem'] | 8,071,269 | [['M01.060.116'], ['C23.550.291.500'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['E02.319.283'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.277.350', 'D27.505.954.427.210.350'], ['M01.060.116.630'], ['D26.660', 'E02.785'], ['E01.370.520.625'], ['F02.808',... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Lactococcus petauri sp. nov., isolated from an abscess of a sugar glider. | A strain of lactic acid bacteria, designated 159469T, isolated from a facial abscess in a sugar glider, was characterized genetically and phenotypically. Cells of the strain were Gram-stain-positive, coccoid and catalase-negative. Morphological, physiological and phylogenetic data indicated that the isolate belongs to ... | ['Abscess', 'Animals', 'Bacterial Typing Techniques', 'Base Composition', 'DNA, Bacterial', 'Fatty Acids', 'Genes, Bacterial', 'Lactococcus', 'Marsupialia', 'Nucleic Acid Hybridization', 'Phylogeny', 'Pigmentation', 'RNA, Ribosomal, 16S', 'Sequence Analysis, DNA'] | 28,945,531 | [['C01.830.025', 'C23.550.470.756.100'], ['B01.050'], ['E01.370.225.875.150.125', 'E05.200.875.150.125'], ['G02.111.080'], ['D13.444.308.212'], ['D10.251'], ['G05.360.340.024.340.364.249', 'G05.360.340.358.024.249', 'G05.360.340.358.207.249'], ['B03.353.750.737.500', 'B03.510.400.800.500', 'B03.510.550.737.500'], ['B01... | ['Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Information Science [L]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Help Desk Answers: What's the most effective topical Tx for scalp psoriasis? | Single-agent therapy with a very potent or potent topical corticosteroid appears more effective than other topical agents, including vitamin D₃ analogues, for treating scalp psoriasis. | ['Administration, Topical', 'Adrenal Cortex Hormones', 'Bone Density Conservation Agents', 'Facial Dermatoses', 'Humans', 'Psoriasis', 'Scalp Dermatoses', 'Vitamin D'] | 27,474,825 | [['E02.319.267.120'], ['D06.472.040'], ['D27.505.696.242'], ['C17.800.271'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C17.800.859.675'], ['C17.800.738'], ['D04.210.500.812.768']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Improved prediction of intrauterine growth retardation with use of multiple parameters. | Several sonographic parameters have been proposed for predicting intrauterine growth retardation (IUGR), but each has been shown to have a low positive predictive value. To predict IUGR more reliably, the authors developed a multiparameter approach based on sonographic and clinical data from 62 fetuses with IUGR and 91... | ['Amniotic Fluid', 'Blood Pressure', 'Body Weight', 'Female', 'Fetal Growth Retardation', 'Fetus', 'Humans', 'Hypertension', 'Infant, Newborn', 'Pregnancy', 'Pregnancy Complications, Cardiovascular', 'Risk Factors', 'Ultrasonography'] | 3,289,097 | [['A12.098', 'A16.378.149'], ['E01.370.600.875.249', 'G09.330.380.076'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['C13.703.277.370', 'C16.300.390', 'C23.550.393.450'], ['A16.378'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489... | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Actinomycin-D and dimethylamino-parthenolide synergism in treating human pancreatic cancer cells. | Preclinical Research & Development Pancreatic cancer is the third leading cause of death in the US with a poor 5-year survival rate of 8.5%. A novel anti-cancer drug, dimethylamino parthenolide (DMAPT), is the water-soluble analog of the natural sesquiterpene lactone, parthenolide. The putative modes of action of DMAPT... | ['Aminopyrine', 'Antibiotics, Antineoplastic', 'Apoptosis', 'Dactinomycin', 'Drug Combinations', 'Drug Synergism', 'Growth Inhibitors', 'Humans', 'Pancreatic Neoplasms', 'Tumor Cells, Cultured'] | 30,295,945 | [['D03.383.129.539.850.077'], ['D27.505.954.248.106'], ['G04.146.954.035'], ['D03.633.300.200', 'D04.345.566.252', 'D12.644.641.252'], ['D26.310'], ['G07.690.773.968.477'], ['D27.505.696.377.450'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.274.761', 'C04.588.322.475', 'C06.301.761', 'C06.689.667', 'C19... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Experimental mucormycosis in congenitally athymic (nude) mice. | Athymic nude (nu/nu) mice and their phenotypically normal (nu/+) littermates displayed a similar susceptibility to acute lethal infection with Absidia corymbifera. Although the clinical manifestations of acute infection were also similar in both groups, the nude mice tended to develop more extensive lesions and were le... | ['Animals', 'Brain', 'Heart', 'Immunity', 'Kidney', 'Liver', 'Lung', 'Mice', 'Mice, Nude', 'Mucorales', 'Mucormycosis', 'Thymus Gland'] | 600,304 | [['B01.050'], ['A08.186.211'], ['A07.541'], ['G12.450'], ['A05.810.453'], ['A03.620'], ['A04.411'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.150.900.649.313.992.635.505.500.550.500'], ['B01.300.300.500'], ['C01.150.703.980.600'], ['A10.549.750', 'A15.382.520.604.750']] | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Impact of convective flow on the cellular uptake and transfection activity of lipoplex and adenovirus. | An in vitro cell culture model that mimics in vivo extracellular environment would be useful in developing in vivo gene delivery system. In the present study, a parallel flow model was applied to investigate the impact of convective flow on cellular uptake and transfection activity in endothelial cells. LipofectAMINE P... | ['Adenoviridae', 'Animals', 'Brain', 'DNA, Viral', 'Drug Carriers', 'Endothelial Cells', 'Lipids', 'Mice', 'Transfection', 'Virology'] | 16,819,202 | [['B04.280.030'], ['B01.050'], ['A08.186.211'], ['D13.444.308.568'], ['D26.255.260', 'E02.319.300.380'], ['A11.436.275'], ['D10'], ['B01.050.150.900.649.313.992.635.505.500'], ['E05.393.350.810', 'G05.728.860'], ['H01.158.273.540.859']] | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Production of immunodeficient rabbits by multiplex embryo transfer and multiplex gene targeting. | Immunodeficient mice have been used predominantly in biomedical research. Realizing that large animal species may have an enhanced ability to predict clinical outcome relative to mice, we worked to develop immunodeficient rabbits by CRISPR/Cas9. We first demonstrated that multiplex embryo transfer efficiently produced ... | ['Animals', 'Animals, Genetically Modified', 'CRISPR-Cas Systems', 'Embryo Transfer', 'Female', 'Gene Targeting', 'Genetic Engineering', 'Male', 'Microinjections', 'Models, Animal', 'Rabbits'] | 28,939,872 | [['B01.050'], ['B01.050.050.136', 'B05.620.136'], ['G05.308.203.374.394'], ['E02.875.800.500', 'E05.820.800.500'], ['E05.393.335'], ['E05.393.420'], ['E02.319.267.530.690', 'E05.591.570'], ['E05.598'], ['B01.050.150.900.649.313.968.700']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Ethnicity, self reported psychiatric illness, and intake of psychotropic drugs in five ethnic groups in Sweden. | STUDY OBJECTIVE: This study hypothesises that the presumed increased risk of self reported longstanding psychiatric illness and intake of psychotropic drugs among Iranian, Chilean, Turkish, and Kurdish adults, when these groups are compared with Polish adults, can be explained by living alone, poor acculturation, unemp... | ['Adult', 'Female', 'Humans', 'Iran', 'Iraq', 'Logistic Models', 'Male', 'Mental Disorders', 'Middle Aged', 'Odds Ratio', 'Poland', 'Psychotropic Drugs', 'Socioeconomic Factors', 'South America', 'Sweden', 'Turkey'] | 11,511,645 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.245.500.350'], ['Z01.252.245.500.360'], ['E05.318.740.500.525', 'E05.318.740.600.800.450', 'E05.318.740.750.450', 'E05.599.835.875', 'N05.715.360.750.530.480', 'N05.715.360.750.625.700.450', 'N05.715.360.750.695.470', 'N06.850.520.830.500.525'... | ['Named Groups [M]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Gene transfer in Cryptococcus neoformans by use of biolistic delivery of DNA. | A transformation scheme for Cryptococcus neoformans to yield high-frequency, integrative events was developed. Adenine auxotrophs from a clinical isolate of C. neoformans serotype A were complemented by the cryptococcal phosphoribosylaminoimidazole carboxylase gene (ade2) with a biolistic DNA delivery system. Compariso... | ['Blotting, Southern', 'Carboxy-Lyases', 'Cryptococcus neoformans', 'Genetic Complementation Test', 'Mitosis', 'Restriction Mapping', 'Transfection', 'Transformation, Bacterial'] | 8,444,802 | [['E05.196.401.114', 'E05.301.300.087', 'E05.601.150'], ['D08.811.520.224.125'], ['B01.300.381.258.366', 'B01.300.930.316.366'], ['E05.393.281.526'], ['G04.144.220.220.781', 'G05.113.220.781'], ['E05.393.183.620.650', 'E05.393.712'], ['E05.393.350.810', 'G05.728.860'], ['E05.393.350.810.500', 'G05.728.860.500', 'G05.72... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Prefrontal and temporal gray matter density decreases in opiate dependence. | RATIONALE: There have been only a few structural brain-imaging studies, with varied findings, of opiate-dependent subjects. Voxel-based morphometry (VBM) is suitable for studying whole brain-wise structural brain changes in opiate-dependent subjects.OBJECTIVES: The objective of the current study is to explore gray matt... | ['Adult', 'Axons', 'Female', 'Humans', 'Image Interpretation, Computer-Assisted', 'Magnetic Resonance Imaging', 'Male', 'Opioid-Related Disorders', 'Prefrontal Cortex', 'Psychiatric Status Rating Scales', 'Temporal Lobe'] | 16,369,836 | [['M01.060.116'], ['A08.675.542.145', 'A11.284.180.075', 'A11.671.137', 'A11.671.501.145'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.158.600', 'E01.370.350.350', 'L01.313.500.750.100.158.600'], ['E01.370.350.825.500'], ['C25.775.643.500', 'F03.900.647.500'], ['A08.186.211.200.885.287.500.270.700'], ['F04.... | ['Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Diseases [C]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Mild clinical expression of myasthenia gravis associated with autoimmune thyroid diseases. | Myasthenia gravis (MG) may occur in association with autoimmune thyroid diseases (AITD). The aim of this study was to evaluate the features of MG associated with AITD compared to those of MG without AITD. A total of 129 MG patients (34 men and 95 women; age range, 11-81 yr) were subdivided into: group A, 56 MG patients... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Autoimmune Diseases', 'Child', 'Female', 'Graves Disease', 'Humans', 'Male', 'Middle Aged', 'Myasthenia Gravis', 'Severity of Illness Index', 'Thymoma', 'Thymus Hyperplasia', 'Thymus Neoplasms', 'Thyroid Diseases'] | 9,024,233 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C20.111'], ['M01.060.406'], ['C11.675.349.500', 'C19.874.283.605', 'C19.874.397.370', 'C20.111.555'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C04.588.614.550.500', 'C04.730.856.490', 'C10.114.656', 'C10.57... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Effects of monensin feeding during development on female rats and their offspring. | Monensin, a growth-promoting agent and coccidiostat used in veterinary medicine, was studied in terms of its effects on the development of female rats and their offspring when added to the diet. Young female rats received 100 or 300 ppm monensin mixed with powdered chow diet until adulthood, when they were mated and th... | ['Animals', 'Behavior, Animal', 'Body Weight', 'Coccidiostats', 'Dose-Response Relationship, Drug', 'Female', 'Incisor', 'Male', 'Maternal-Fetal Exchange', 'Monensin', 'Pregnancy', 'Rats', 'Rats, Wistar', 'Sex Factors'] | 10,440,490 | [['B01.050'], ['F01.145.113'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['D27.505.954.122.250.100.170'], ['G07.690.773.875', 'G07.690.936.500'], ['A14.549.167.860.425'], ['G08.686.784.769.455'], ['D03.383.312.600'], ['G08.686.784.769'], ['B01.0... | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Lipidomic analysis of meibomian gland secretions from the tree shrew: Identification of candidate tear lipids critical for reducing evaporation. | Lipids secreted from the meibomian glands form the outermost layer of the tear film and reduce its evaporation. Abnormal changes in the quantities or compositions of lipids present in meibomian gland secretions (meibum) are known to lead to dry eye disease, although the underlying mechanism is not yet well understood. ... | ['Animals', 'Eyelids', 'Female', 'Lipidomics', 'Lipids', 'Mass Spectrometry', 'Meibomian Glands', 'Tears', 'Tupaiidae', 'Volatilization'] | 30,660,743 | [['B01.050'], ['A01.456.505.420.504', 'A09.371.337'], ['H01.158.201.586.500', 'H01.158.273.180.599.500', 'H01.181.122.638.500'], ['D10'], ['E05.196.566'], ['A09.371.337.614', 'A10.336.827.600'], ['A12.200.882'], ['B01.050.150.900.649.313.996.770'], ['G01.645.750', 'G02.734.933']] | ['Organisms [B]', 'Anatomy [A]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
[Prevalence of abnormal hemoglobins in newborns in Natal, Rio Grande do Norte, Brazil]. | Hemoglobinopathies are among the most prevalent hereditary diseases in humans. Studies in different areas of Brazil have identified the prevalence of S and C abnormal hemoglobins. The study analyzed 1,940 cord blood samples of newborns from maternity hospitals in Natal, Rio Grande do Norte State, to investigate the pre... | ['Anemia, Sickle Cell', 'Brazil', 'Fetal Blood', 'Genotype', 'Hemoglobin, Sickle', 'Hemoglobinopathies', 'Hemoglobins, Abnormal', 'Humans', 'Infant, Newborn', 'Neonatal Screening', 'Prevalence'] | 15,029,312 | [['C15.378.071.141.150.150', 'C15.378.420.155', 'C16.320.070.150', 'C16.320.365.155'], ['Z01.107.757.176'], ['A12.207.152.200', 'A15.145.300', 'A16.378.200'], ['G05.380'], ['D12.776.124.400.463.588', 'D12.776.422.316.762.426.588'], ['C15.378.420', 'C16.320.365'], ['D12.776.124.400.463', 'D12.776.422.316.762.426'], ['B0... | ['Diseases [C]', 'Geographicals [Z]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
[Principal component analysis of Y-chromosome haplotype distribution in 18 ethnic groups in Yunnan Province]. | Based on the historical records, 18 of the 26 ethnic groups in Yunnan Province are the descendant populations of three ancient tribes, Bai-Yue, Bai-Pu and Di-Qiang, linguistically belonging to the Daic, Austro-Asiatic and Tibeto-Burman, respectively. In order to trace the origins of these native ethnic groups, a total ... | ['Asian Continental Ancestry Group', 'China', 'Chromosomes, Human, Y', 'Haplotypes', 'Humans'] | 15,552,035 | [['M01.686.508.200'], ['Z01.252.474.164'], ['A11.284.187.520.300.505.757', 'A11.284.187.865.983.500', 'G05.360.162.520.300.505.757', 'G05.360.162.865.983.500'], ['G05.380.360'], ['B01.050.150.900.649.313.988.400.112.400.400']] | ['Named Groups [M]', 'Geographicals [Z]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
Zonisamide and renal calculi in patients with epilepsy: how big an issue? | OBJECTIVES: To determine the prevalence of renal calculi in patients treated with zonisamide during randomized, controlled and open-label clinical trials, and from post-marketing surveillance data.METHODS: Reports of renal calculi from four placebo-controlled double-blind trials of zonisamide, their long-term open-labe... | ['Adolescent', 'Adult', 'Anticonvulsants', 'Child', 'Double-Blind Method', 'Epilepsy', 'Female', 'Fructose', 'Humans', 'Isoxazoles', 'Kidney Calculi', 'Male', 'Middle Aged', 'Placebos', 'Product Surveillance, Postmarketing', 'Topiramate', 'Ultrasonography', 'Zonisamide'] | 17,594,758 | [['M01.060.057'], ['M01.060.116'], ['D27.505.954.427.080'], ['M01.060.406'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['C10.228.140.490'], ['D09.947.875.359.250', 'D09.947.875.465.354'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.383.129.385'], ['C12.777.419.600.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Malignant degeneration of a juvenile laryngeal papilloma--a follow-up study. | The patient, a non-smoking woman aged 51, had been suffering from recurrent juvenile papilloma for 38 years. After eight years during which there was increasing atypia, an extensive malignant papillary tumor, with extralaryngeal spread, was diagnosed. Only seven cases of malignant degeneration of non-irradiated juvenil... | ['Carcinoma, Squamous Cell', 'Female', 'Follow-Up Studies', 'Humans', 'Laryngeal Cartilages', 'Laryngeal Neoplasms', 'Middle Aged', 'Neoplasm Recurrence, Local', 'Papilloma'] | 7,420,523 | [['C04.557.470.200.400', 'C04.557.470.700.400'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.165.257.625', 'A02.165.407.500', 'A04.329.591'], ['C04.588.443.665.481', 'C08.360.369', 'C08.785.481', 'C09.400.369', 'C09.64... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Named Groups [M]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Maturation-dependent behavioral deficits and cell injury in developing animals during the subacute postictal period. | Prolonged early-life seizures are associated with disruptions of affective and cognitive function. Postictal disturbances, temporary functional deficits that persist for hours to days after seizures, have not yet been thoroughly characterized. Here, we used kainic acid (KA) to induce status epilepticus (SE) in immature... | ['Age Factors', 'Analysis of Variance', 'Animals', 'Animals, Newborn', 'Avoidance Learning', 'Brain', 'DNA Fragmentation', 'Disease Models, Animal', 'Exploratory Behavior', 'Kainic Acid', 'Male', 'Maze Learning', 'Mental Disorders', 'Motor Activity', 'Rats', 'Rats, Long-Evans', 'Rotarod Performance Test', 'Seizures'] | 23,973,645 | [['N05.715.350.075', 'N06.850.490.250'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['B01.050'], ['B01.050.050.282'], ['F02.463.425.097', 'F02.463.785.373.173'], ['A08.186.211'], ['G05.200.230'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['F01.145.387', 'F01.658.370'], ['D03.383.773.400'], ... | ['Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Oxidation of linoleic acid encapsulated with gum arabic or maltodextrin by spray-drying. | Linoleic acid was emulsified with gum arabic or maltodextrin at various weight ratios of the acid to the polysaccharide in the presence or absence of a small-molecule emulsifier. The emulsions were spray-dried to produce microcapsules. Emulsions prepared with gum arabic were smaller in droplet size and more stable than... | ['Drug Compounding', 'Drug Stability', 'Emulsions', 'Gum Arabic', 'Linoleic Acid', 'Oxidation-Reduction', 'Particle Size', 'Polysaccharides'] | 11,837,973 | [['E05.916.270'], ['E05.916.330'], ['D20.280.260', 'D26.255.165.260'], ['D05.750.078.739.500', 'D09.698.700.500', 'D20.215.721.249.500'], ['D10.251.355.310.515.500', 'D10.251.355.343.500.500'], ['G02.700', 'G03.295.531'], ['G02.712'], ['D09.698']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of Auricular Acupressure on Sleep Quality, Anxiety, and Depressed Mood in RN-BSN Students With Sleep Disturbance. | BACKGROUND: Students in 2-year registered nurse to Bachelor of Science in nursing (RN-BSN) programs usually work full-time and study part-time. Sleep disturbance, anxiety, and depression are known to be common health problems among these students.Prior research has described the effectiveness of auricular acupressure (... | ['Acupuncture, Ear', 'Adult', 'Anxiety', 'Depression', 'Education, Nursing, Baccalaureate', 'Female', 'Humans', 'Middle Aged', 'Psychiatric Status Rating Scales', 'Sleep Wake Disorders', 'Students, Nursing', 'Taiwan', 'Treatment Outcome', 'Young Adult'] | 29,315,203 | [['E02.190.044.133', 'E02.190.204.500'], ['M01.060.116'], ['F01.470.132'], ['F01.145.126.350'], ['I02.358.462.316'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['F04.711.513.653'], ['C10.886', 'C23.888.592.796', 'F03.870'], ['M01.848.769.685'], ['Z01.252.474.872', 'Z01.639.850'], ['E01.789.80... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Aprotinin for primary coronary artery bypass grafting: a multicenter trial of three dose regimens. | BACKGROUND: High-dose aprotinin reduces transfusion requirements in patients undergoing coronary artery bypass grafting, but the safety and effectiveness of smaller doses is unclear. Furthermore, patient selection criteria for optimal use of the drug are not well defined.METHODS: Seven hundred and four first-time coron... | ['Aged', 'Aprotinin', 'Blood Loss, Surgical', 'Blood Transfusion', 'Coronary Artery Bypass', 'Double-Blind Method', 'Female', 'Hemostatics', 'Humans', 'Intraoperative Complications', 'Male', 'Middle Aged', 'Myocardial Infarction', 'Risk Factors'] | 8,957,369 | [['M01.060.116.100'], ['D12.776.083'], ['C23.550.414.300', 'C23.550.505.300'], ['E02.095.135'], ['E04.100.376.719.332', 'E04.100.814.868.750', 'E04.928.220.520.220'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['D27.505.954.502.270.463'], ['B01.050.150.900.649.313.988.400.112.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Overexpression of SOX15 inhibits proliferation of NT2/D1 cells derived from a testicular embryonal cell carcinoma. | SOX (Sry-related HMG box) family proteins, which have an evolutionarily conserved DNA binding domain, have crucial roles in cell differentiation. However, their target genes remain enigmatic. Some members of the SOX family may have roles in regulation of cell proliferation. We established stable NT2/D1 cell lines overe... | ['Carcinoma, Embryonal', 'Cell Line, Tumor', 'Cell Proliferation', 'DNA-Binding Proteins', 'Flow Cytometry', 'Gene Expression', 'High Mobility Group Proteins', 'Humans', 'Male', 'Oligonucleotide Array Sequence Analysis', 'RNA, Messenger', 'Reverse Transcriptase Polymerase Chain Reaction', 'SOX Transcription Factors', '... | 18,182,846 | [['C04.557.465.200'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.161.750', 'G07.345.249.410.750'], ['D12.776.260'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.200.500.386.350', 'E05.242.363.342', 'E05.242.386.350'], ['G05.297'], ['D12.776.660.235... | ['Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Optic disc contractility in morning glory disc anomaly. | Morning glory disc anomaly is a sporadic congenital abnormality of the optic disc that is often unilateral. These eyes possess heterotropic smooth muscle and can undergo spontaneous contraction with transient vision loss. The authors report an unusual case of contractility of a morning glory disc anomaly induced by ocu... | ['Blepharoptosis', 'Child, Preschool', 'Contracture', 'Female', 'Humans', 'Magnetic Resonance Imaging', 'Microphthalmos', 'Muscle, Smooth', 'Optic Disk', 'Optic Nerve Diseases', 'Visual Acuity'] | 21,323,306 | [['C11.338.204'], ['M01.060.406.448'], ['C05.550.323', 'C05.651.197'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['C11.250.566', 'C16.131.384.666'], ['A02.633.570', 'A10.690.467'], ['A08.800.800.120.680.660', 'A09.371.729.690'], ['C10.292.700', 'C11.640'], ['E01.370.380.850.950', 'F02.46... | ['Diseases [C]', 'Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Roaming through the methodology. XX. Randomization as a means of avoiding confounding through indication]. | Two methodological issues are central in discussions about the value of randomised studies for evaluation of the effectiveness of medical interventions: confounding by indication and generalizability. Confounding occurs when a factor with bearing on the outcome of disease, has a different distribution among interventio... | ['Bias', 'Confounding Factors, Epidemiologic', 'Controlled Clinical Trials as Topic', 'Humans', 'Randomized Controlled Trials as Topic', 'Research', 'Research Design'] | 10,949,635 | [['N05.715.350.150', 'N06.850.490.500'], ['N05.715.350.240', 'N06.850.490.718'], ['E05.318.372.250.250.365', 'N05.715.360.330.250.250.365', 'N06.850.520.450.250.250.365'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.250.250.365.500', 'N05.715.360.330.250.250.365.500', 'N06.850.520.450.250.250.365.500... | ['Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
[A Giant Right Coronary Artery Aneurysm Exceeding 8-cm in Size]. | A coronary artery aneurysm(CAA) that exceeds 20 mm in diameter is rare. In this case report, we describe the operative correction of a giant right CAA measuring greater than 8 cm in diameter. A 51-year-old male with a history of Kawasaki disease at 7 years of age was admitted to our hospital for evaluation of an abnorm... | ['Cardiovascular Surgical Procedures', 'Coronary Aneurysm', 'Coronary Artery Disease', 'Humans', 'Imaging, Three-Dimensional', 'Male', 'Middle Aged', 'Tomography, X-Ray Computed'] | 26,066,873 | [['E04.100'], ['C14.280.647.250.250', 'C14.907.055.395', 'C14.907.585.250.250'], ['C14.280.647.250.260', 'C14.907.137.126.339', 'C14.907.585.250.260'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.400', 'L01.224.308.410'], ['M01.060.116.630'], ['E01.370.350.350.810', 'E01.370.350.600.350.700.810', 'E0... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Information Science [L]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
A cost-effectiveness analysis of amniocentesis and chorionic villus sampling for prenatal genetic testing. | Amniocentesis and chorionic villus sampling are tests for the prenatal diagnosis of cytogenetic abnormalities. We calculated the incremental costs per abnormal birth averted, and the incremental costs per quality-adjusted outcome, of amniocentesis and chorionic villus sampling performed for the indication of maternal a... | ['Adult', 'Amniocentesis', 'Anxiety', 'Chorionic Villi Sampling', 'Chromosome Aberrations', 'Chromosome Disorders', 'Cohort Studies', 'Cost-Benefit Analysis', 'Decision Support Techniques', 'Female', 'Genetic Testing', 'Health Policy', 'Health Services Research', 'Humans', 'Maternal Age', 'Middle Aged', 'Outcome Assess... | 8,057,700 | [['M01.060.116'], ['E01.370.225.500.384.050', 'E01.370.225.998.329.309', 'E01.370.378.630.050', 'E04.665.600.309', 'E05.200.500.384.050', 'E05.200.998.329.309', 'E05.242.384.050'], ['F01.470.132'], ['E01.370.225.500.384.100.149', 'E01.370.225.998.054.149', 'E01.370.378.630.150', 'E01.370.388.100.150', 'E04.074.149', 'E... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Information Science [L]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Disciplines and Occupations [H]', 'O... | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
Design of Large-Scale Reporter Construct Arrays for Dynamic, Live Cell Systems Biology. | Dynamic systems biology aims to identify the molecular mechanisms governing cell fate decisions through the analysis of living cells. Large scale molecular information from living cells can be obtained from reporter constructs that provide activities for either individual transcription factors or multiple factors bindi... | ['A549 Cells', 'Algorithms', 'Binding Sites', 'Epithelial-Mesenchymal Transition', 'Gene Regulatory Networks', 'Genes, Reporter', 'Humans', 'Promoter Regions, Genetic', 'Research Design', 'Smad3 Protein', 'Systems Biology', 'Transcription Factors', 'Transforming Growth Factor beta', 'Tumor Suppressor Protein p53'] | 30,189,139 | [['A11.251.210.190.080', 'A11.251.860.180.080', 'A11.436.054'], ['G17.035', 'L01.224.050'], ['G02.111.570.120'], ['G04.356.500'], ['G05.360.080.689.360'], ['G05.360.340.024.340.435'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.111.570.080.689.675', 'G05.360.080.689.675', 'G05.360.340.024.340.137.750.680'], ... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Electrical lumped model for arterial vessel beds. | Numerous electrical analog models of the circulatory system have been proposed. However, conventional models are either too simple, focusing exclusively on heart function, or overly complex, characterizing arteries in excessive detail. The vessel beds, which comprise arteries, capillaries and veins, are well known to b... | ['Arteries', 'Blood Pressure', 'Models, Anatomic'] | 14,980,403 | [['A07.015.114'], ['E01.370.600.875.249', 'G09.330.380.076'], ['J01.897.280.500.545.129', 'L01.178.820.090.545.129']] | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]'] | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Development of a new binding phase for the diffusive gradients in thin films technique based on an ionic liquid for mercury determination. | Determining bioavailable trace concentrations of mercury (Hg) in water is still a challenging analytical task. In this study, we report a methodology for determining labile Hg in natural waters using newly developed sorbents. Silicon dioxide at a nanoparticle range (Si-np) and cellulose powder at a microparticle range ... | ['Adsorption', 'Diffusion', 'Environmental Monitoring', 'Ionic Liquids', 'Mercury', 'Methods', 'Polymers', 'Quaternary Ammonium Compounds', 'Water Pollutants, Chemical'] | 31,883,501 | [['G01.030', 'G02.020'], ['G01.202', 'G02.196'], ['N06.850.460.350.080', 'N06.850.780.375'], ['D27.720.844.500'], ['D01.268.556.504', 'D01.268.956.437', 'D01.552.544.504'], ['E05.581'], ['D05.750', 'D25.720', 'J01.637.051.720'], ['D01.625.062.500', 'D02.092.877', 'D02.675.276'], ['D27.888.284.903.655']] | ['Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Validation of the Clinical Index of Stable Febrile Neutropenia (CISNE) model in febrile neutropenia patients visiting the emergency department. Can it guide emergency physicians to a reasonable decision on outpatient vs. inpatient treatment? | Advances in oncology have enabled physicians to treat low-risk febrile neutropenia (FN) in outpatient settings. This study was aimed to explore the usefulness of the CISNE model and identify better triage in the emergency setting. This is a retrospective cohort study on 400 adult FN patients presenting to the Emergency... | ['Adult', 'Aged', 'Ambulatory Care', 'Antineoplastic Agents', 'Chemotherapy-Induced Febrile Neutropenia', 'Clinical Decision-Making', 'Databases, Factual', 'Emergency Service, Hospital', 'Female', 'Hospitalization', 'Humans', 'Male', 'Middle Aged', 'Neoplasms', 'Republic of Korea', 'Retrospective Studies'] | 30,596,803 | [['M01.060.116'], ['M01.060.116.100'], ['E02.760.106', 'N02.421.585.106'], ['D27.505.954.248'], ['C15.378.553.546.184.564.750.500'], ['E01.055'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['N02.278.216.500.968.336', 'N02.421.297.195', 'N04.452.442.452.422.336'], ['E02.760.400', 'N02.421.585.400'], ['B01.050.1... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Information Science [L]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
The mechanism for the renal hemodynamic and tubular action of furosemide. | The mechanism for the renal hemodynamic and tubular action of furosemide (F) was investigated in nine anesthetized dogs. F was administered intrarenally at 50 micrograms/ml/min in isotonic saline with and without the addition of indomethacin (I) at 36 micrograms/ml/min and PGE1 at 2 micrograms/ml/min in isotonic saline... | ['Animals', 'Dogs', 'Female', 'Furosemide', 'Hemodynamics', 'Indomethacin', 'Kidney', 'Kidney Tubules', 'Male', 'Prostaglandins E'] | 7,224,727 | [['B01.050'], ['B01.050.150.900.649.313.750.250.216.200'], ['D02.065.884.725.300', 'D02.092.146.807.300', 'D02.886.590.700.725.300'], ['G09.330.380'], ['D03.633.100.473.420'], ['A05.810.453'], ['A05.810.453.736.560'], ['D10.251.355.255.550.250', 'D23.469.050.175.725.250']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Azelaic acid foam 15% in the treatment of papulopustular rosacea: a randomized, double-blind, vehicle-controlled study. | Rosacea is a common chronic inflammatory skin disease that primarily affects facial skin. Its etiology is unknown, and currently there is no cure. Rosacea can be associated with severe symptoms, including transient erythema (flushing), nontransient erythema, papules, pustules, and telangiectases, leading to substantial... | ['Administration, Cutaneous', 'Adult', 'Aged', 'Aged, 80 and over', 'Dermatologic Agents', 'Dicarboxylic Acids', 'Double-Blind Method', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Middle Aged', 'Rosacea', 'Severity of Illness Index', 'Treatment Outcome', 'Young Adult'] | 24,416,747 | [['E02.319.267.120.060'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.954.444'], ['D02.241.081.337'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.15... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Association of the gene encoding wingless-type mammary tumor virus integration-site family member 5B (WNT5B) with type 2 diabetes. | Recent reports have suggested that WNT signaling is an important regulator for adipogenesis or insulin secretion and might be involved in the pathogenesis of type 2 diabetes. To investigate possible roles of the WNT genes in conferring susceptibility to type 2 diabetes, we examined the association of the genes that enc... | ['3T3 Cells', 'Adipocytes', 'Animals', 'Base Sequence', 'DNA Primers', 'Diabetes Mellitus, Type 2', 'Gene Expression Regulation', 'Gene Frequency', 'Genotype', 'Humans', 'Japan', 'Linkage Disequilibrium', 'Liver', 'Mice', 'Molecular Sequence Data', 'Multigene Family', 'Pancreas', 'Polymorphism, Single Nucleotide', 'Pro... | 15,386,214 | [['A11.251.210.100', 'A11.329.228.100'], ['A11.329.114'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['C18.452.394.750.149', 'C19.246.300'], ['G05.308'], ['G05.330'], ['G05.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['... | ['Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 |
[Anti-inflammatory effect of radix Angelicae sinensis]. | Radix Angelicae Sinensis (RAS) decoction can markedly inhibit acute and chronic inflammation caused by various phlogistic agents. Similar effects are equally seen in adrenalectomized rats. RAS can also suppress the biosynthesis or release of prostaglandin E2 in inflamed tissues induced by carrageenan, as well as signif... | ['Animals', 'Anti-Inflammatory Agents, Non-Steroidal', 'Capillary Permeability', 'Dinoprostone', 'Drugs, Chinese Herbal', 'Female', 'Guinea Pigs', 'Male', 'Mice', 'Rats', 'Rats, Inbred Strains'] | 1,804,177 | [['B01.050'], ['D27.505.696.663.850.014.040.500', 'D27.505.954.158.030', 'D27.505.954.329.030'], ['G03.143.330', 'G09.330.165'], ['D10.251.355.255.550.250.200', 'D23.469.050.175.725.250.200'], ['D20.215.784.500.350', 'D26.335'], ['B01.050.150.900.649.313.992.550'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
High glucose, glucose fluctuation and carbonyl stress enhance brain microvascular endothelial barrier dysfunction: Implications for diabetic cerebral microvasculature. | We previously demonstrated that in normal glucose (5mM), methylglyoxal (MG, a model of carbonyl stress) induced brain microvascular endothelial cell (IHEC) dysfunction that was associated with occludin glycation and prevented by N-acetylcysteine (NAC). Herein, we investigated the impact of high glucose and low GSH, con... | ['Acetylcysteine', 'Animals', 'Brain', 'Buthionine Sulfoximine', 'Cell Line', 'Diabetes Mellitus, Experimental', 'Endothelial Cells', 'Free Radical Scavengers', 'Glucose', 'Glutathione', 'Glycosylation', 'Humans', 'Lactoylglutathione Lyase', 'Male', 'Microvessels', 'Occludin', 'Oxidative Stress', 'Pyruvaldehyde', 'Rats... | 25,867,911 | [['D02.886.030.230.259', 'D12.125.166.230.259'], ['B01.050'], ['A08.186.211'], ['D02.886.030.676.620.125', 'D12.125.166.676.620.125'], ['A11.251.210'], ['C18.452.394.750.074', 'C19.246.240', 'E05.598.500.374'], ['A11.436.275'], ['D27.505.519.217.500'], ['D09.947.875.359.448'], ['D12.644.456.448'], ['G02.111.158.812', '... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Synthesis of ring halogenated prostaglandins (1). | The synthesis of nine mono- and difluoro prostaglandins XIII, XV, XXIV, XXVII, XXXII, XXXVIII, XLV, LI and LIV, and two monochloro prostaglandins LVII and LXI, from appropriately protected derivatives of natural PGF2 is described. | ['Chlorine', 'Fluorine', 'Magnetic Resonance Spectroscopy', 'Methods', 'Prostaglandins, Synthetic'] | 704,924 | [['D01.268.380.150', 'D01.362.225'], ['D01.268.380.300'], ['E05.196.867.519'], ['E05.581'], ['D10.251.355.255.550.775', 'D23.469.050.175.725.775', 'D23.469.700']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Exploring the Experiences, Challenges, and Approaches of Parish Nurses in Their Community Practice. | PURPOSE: To explore the personal experiences, challenges, and practices of parish nurses in their communities.METHOD/DESIGN: The overall study used a mixed methods concurrent embedded design to describe parish nurses' experiences with diabetes education and preconception counseling in their practice. Also included were... | ['Aged', 'Female', 'Focus Groups', 'Humans', 'Middle Aged', 'New England', 'Parish Nursing', 'Public Health', 'Qualitative Research', 'Spirituality'] | 30,270,721 | [['M01.060.116.100'], ['E05.318.308.112', 'N05.715.360.300.269', 'N06.850.520.308.112'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['Z01.107.567.875.550'], ['H02.478.676.150.750', 'N02.421.143.150.750'], ['H02.403.720', 'N01.400.550', 'N06.850'], ['H01.770.644.241.850'], ['F02.880.705', 'K01... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Disciplines and Occupations [H]', 'Psychiatry and Psychology [F]', 'Humanities [K]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
Comparison of propofol and thiopental as anesthetic agents for electroconvulsive therapy: a randomized, blinded comparison of seizure duration, stimulus charge, clinical effect, and cognitive side effects. | OBJECTIVES: To compare propofol and thiopental as anesthetic agents for electroconvulsive therapy (ECT) with respect to seizure duration, stimulus charge, clinical effect, and cognitive side effects.METHODS: Randomized, blinded study of 62 depressed patients treated with bilateral ECT. Algorithm-based charge dosing was... | ['Adult', 'Aged', 'Algorithms', 'Anesthesia, Intravenous', 'Anesthetics, Intravenous', 'Cognition Disorders', 'Double-Blind Method', 'Electroconvulsive Therapy', 'Female', 'Humans', 'Male', 'Middle Aged', 'Monitoring, Physiologic', 'Neuropsychological Tests', 'Propofol', 'Seizures', 'Thiopental', 'Young Adult'] | 19,092,676 | [['M01.060.116'], ['M01.060.116.100'], ['G17.035', 'L01.224.050'], ['E03.155.308'], ['D27.505.696.277.100.035.075', 'D27.505.954.427.210.100.035.075'], ['F03.615.250'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['F04.570.200.583', 'F04.669.224.300'], ['B01.050.150.900.649.313... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Considerations in developing an integrated pest management programme for control of sea lice on farmed salmon in Pacific Canada. | In the development of integrated pest management (IPM) plans for the control of sea lice there are some components that are common to many areas. However, effective plans must be tailored to regionally varying environmental and biological factors affecting the severity of sea lice infections. This paper describes facto... | ['Animals', 'British Columbia', 'Copepoda', 'Ectoparasitic Infestations', 'Fish Diseases', 'Fisheries', 'Pacific Ocean', 'Pest Control', 'Program Development', 'Salmon'] | 19,245,631 | [['B01.050'], ['Z01.107.567.176.160'], ['B01.050.500.131.365.160'], ['C01.610.858.211'], ['C22.362'], ['J01.040.168.300', 'J03.540.280'], ['Z01.756.700'], ['N06.850.780.200.650'], ['N04.452.760'], ['B01.050.150.900.493.817.750.705']] | ['Organisms [B]', 'Geographicals [Z]', 'Diseases [C]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
[Aberrant right subclavian artery (arteria lusoria) and the risk for trisomy 21. Retrospective study of 11,479 fetopathological examinations]. | OBJECTIVE: The aberrant right subclavian artery is a malformation of the aortic arch present at less than 2 % of the individuals in the general population. This incidence is higher in trisomy 21, making it possible use the aberrant right subclavian artery as a prenatal marker of trisomy 21.MATERIAL AND METHODS: This wo... | ['Aneurysm', 'Cardiovascular Abnormalities', 'Deglutition Disorders', 'Down Syndrome', 'Female', 'Humans', 'Pregnancy', 'Retrospective Studies', 'Risk Factors', 'Subclavian Artery', 'Ultrasonography, Prenatal'] | 24,332,742 | [['C14.907.055'], ['C14.240', 'C16.131.240'], ['C06.405.117.119', 'C09.775.174'], ['C10.597.606.360.220', 'C16.131.077.327', 'C16.131.260.260', 'C16.320.180.260'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G08.686.784.769'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', ... | ['Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
A posteriori time-varying filtering of averaged evoked potentials. I. Introduction and conceptual basis. | This paper forms a preface and introduction to a new method for the estimation of evoked potentials: a posteriori time-varying filtering. A simple evoked potential model, consisting of a transient signal and additive noise, is discussed and the underlying assumptions explicitly formulated. Assuming this model, the prob... | ['Brain', 'Evoked Potentials', 'Humans', 'Models, Biological', 'Statistics as Topic', 'Time Factors'] | 7,317,519 | [['A08.186.211'], ['G07.265.216.500', 'G11.561.200.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.395'], ['E05.318.740', 'H01.548.832', 'N05.715.360.750', 'N06.850.520.830'], ['G01.910.857']] | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Synthesis and antiherpetic activity of (S)-, (R)-, and (+/-)-9-[(2,3-dihydroxy-1-propoxy)methyl]guanine, linear isomers of 2'-nor-2'-deoxyguanosine. | Racemic 9-[(2,3-dihydroxy-1-propoxy)methyl]guanine [(+/-)-iNDG], a new analogue of acyclovir (ACV) and a structural analogue of 2'-nor-2'-deoxyguanosine (2'NDG), was synthesized and found to inhibit the replication of herpes simplex virus types 1 (HSV-1) and 2 (HSV-2). Subsequently, its optical isomers, (R)- and (S)-iN... | ['Acyclovir', 'Animals', 'Chemical Phenomena', 'Chemistry', 'Ganciclovir', 'Herpes Simplex', 'Isomerism', 'Mice', 'Nucleic Acid Synthesis Inhibitors', 'Rabbits', 'Simplexvirus', 'Structure-Activity Relationship', 'Thymidine Kinase', 'Virus Replication'] | 2,989,523 | [['D03.633.100.759.758.399.454.250'], ['B01.050'], ['G02'], ['H01.181'], ['D03.633.100.759.758.399.454.250.300'], ['C01.925.256.466.382', 'C01.925.825.320', 'C17.800.838.790.320'], ['G02.111.570.685', 'G02.607.445'], ['B01.050.150.900.649.313.992.635.505.500'], ['D27.505.519.389.675'], ['B01.050.150.900.649.313.968.700... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
src family kinases regulate renal epithelial paracellular permeability barrier through an occludin-independent mechanism. | Paracellular permeability is mediated by the epithelial cell tight junction. Studies in intestinal and other epithelia have suggested that the activity of src family kinases (SFKs) increases epithelial paracellular permeability through its action on the tight junction protein, occludin, but the involvement of SFKs and ... | ['Actins', 'Animals', 'Dextrans', 'Dogs', 'Dose-Response Relationship, Drug', 'Epithelial Cells', 'Fluoresceins', 'Kidney Tubules', 'LLC-PK1 Cells', 'Madin Darby Canine Kidney Cells', 'Occludin', 'Permeability', 'Protein Kinase Inhibitors', 'Protein Transport', 'Swine', 'Tight Junctions', 'Time Factors', 'Transfection'... | 23,129,414 | [['D05.750.078.730.250', 'D12.776.210.500.100', 'D12.776.220.525.255'], ['B01.050'], ['D05.750.078.562.272', 'D09.698.365.272'], ['B01.050.150.900.649.313.750.250.216.200'], ['G07.690.773.875', 'G07.690.936.500'], ['A11.436'], ['D02.455.426.779.347', 'D03.633.300.953.275', 'D04.711.347'], ['A05.810.453.736.560'], ['A11... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
An audit of the quality of root canal treatments performed by undergraduate dental students on single-rooted teeth in Glasgow dental hospital and school. | The aim of this investigation was to assess the technical quality of root canal treatments performed by undergraduate dental students on single rooted teeth at the Glasgow Dental Hospital and School. One hundred radiographs of single rooted teeth that had root canal treatment were randomly selected and examined under e... | ['Education, Dental', 'Humans', 'Radiography', 'Retrospective Studies', 'Root Canal Therapy', 'Schools, Dental', 'Scotland', 'Students, Dental', 'Tooth Root', 'Tooth, Nonvital'] | 17,645,068 | [['I02.358.274'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.700'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.520.450.500.500.500', 'N06.850.520.450.500.750.825'], ['E06.397.778'], ['I02.783.495.481'], ['Z01.542.363.... | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Named Groups [M]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
A rare postoperative complication of anterior lower thoracic instrumentation: diaphragmatic laceration with hemothorax. | PURPOSE: To highlight the importance of preventing visceral injury due to prominent anterior implants at the spinal column.METHODS: A 52-year-old man with cord compression was treated with a T9/10 discectomy and instrumented fusion via a right thoracotomy and trans-pleural approach. Postoperatively, he had improved low... | ['Diaphragm', 'Diskectomy', 'Hemothorax', 'Humans', 'Intervertebral Disc Displacement', 'Lacerations', 'Male', 'Middle Aged', 'Postoperative Complications', 'Postoperative Period', 'Spinal Cord Compression', 'Spinal Fusion', 'Thoracotomy'] | 28,035,466 | [['A02.633.567.900.300'], ['E02.718.444', 'E04.188.350', 'E04.555.200'], ['C08.528.380', 'C23.550.414.904'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C05.116.900.307', 'C23.300.707.952'], ['C26.540'], ['M01.060.116.630'], ['C23.550.767'], ['E04.614.750', 'N02.421.585.753.750'], ['C10.228.854.761', 'C26.819.67... | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Fibroblastic reticular cells regulate intestinal inflammation via IL-15-mediated control of group 1 ILCs. | Fibroblastic reticular cells (FRCs) of secondary lymphoid organs form distinct niches for interaction with hematopoietic cells. We found here that production of the cytokine IL-15 by FRCs was essential for the maintenance of group 1 innate lymphoid cells (ILCs) in Peyer's patches and mesenteric lymph nodes. Moreover, F... | ['Animals', 'Cells, Cultured', 'Citrobacter rodentium', 'Coronavirus Infections', 'Enterobacteriaceae Infections', 'Fibroblasts', 'Immunity, Innate', 'Interleukin-15', 'Lymph Nodes', 'Lymphocytes', 'Mice', 'Mice, Inbred C57BL', 'Mice, Knockout', 'Murine hepatitis virus', 'Myeloid Differentiation Factor 88', "Peyer's Pa... | 27,798,617 | [['B01.050'], ['A11.251'], ['B03.440.450.425.200.737', 'B03.660.250.150.100.737'], ['C01.925.782.600.550.200'], ['C01.150.252.400.310'], ['A11.329.228'], ['G12.450.564'], ['D12.644.276.374.465.515', 'D12.776.467.374.465.515', 'D23.529.374.465.515'], ['A10.549.400', 'A15.382.520.604.412'], ['A11.118.637.555.567', 'A15.1... | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Adsorptive removal of fluoride from water by granular zirconium-aluminum hybrid adsorbent: performance and mechanisms. | Granular zirconium-aluminum hybrid adsorbent (GZAHA) was fabricated for efficient defluoridation of groundwater in filter application. GZAHA was formed through the aggregation of massive Zr/Al oxide nanoparticles with an amorphous pattern. This adsorbent has a satisfactory mechanical strength, a specific surface area o... | ['Adsorption', 'Aluminum', 'Fluorides', 'Groundwater', 'Kinetics', 'Oxides', 'Water Pollutants, Chemical', 'Zirconium'] | 29,564,704 | [['G01.030', 'G02.020'], ['D01.268.557.050', 'D01.552.547.050'], ['D01.248.497.158.380', 'D01.303.350.300'], ['G01.311.355'], ['G01.374.661', 'G02.111.490'], ['D01.248.497.158.685', 'D01.650.550'], ['D27.888.284.903.655'], ['D01.268.556.950', 'D01.268.956.937', 'D01.552.544.950']] | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Glucose-depleted medium reduces the collagen content of human skin fibroblast cultures. | Glucose deprivation appeared to be a factor which induces oxygen regulated protein (ORP) 150 expression in the human skin fibroblasts cultures. Whereas glucose deprivation resulted in a slight (statistically insignificant) decrease of protein content in these cultures, a marked decrease of collagen content was observed... | ['Cells, Cultured', 'Collagen', 'Culture Media', 'Fibroblasts', 'Gelatinases', 'Glucose', 'HSP70 Heat-Shock Proteins', 'Humans', 'Integrin beta1', 'Proteins', 'Receptor, IGF Type 1', 'Skin'] | 17,588,139 | [['A11.251'], ['D05.750.078.280', 'D12.776.860.300.250'], ['D27.720.470.305', 'E07.206'], ['A11.329.228'], ['D08.811.277.656.300.480.252', 'D08.811.277.656.675.374.252'], ['D09.947.875.359.448'], ['D12.776.580.216.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.543.750.705.408.200.500'], ['D12.776'], ... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Histopathological grade and response to chemotherapy in advanced soft tissue sarcomas. | In a retrospective analysis, we evaluated the possible significance of histopathological grade with regard to response to chemotherapy in advanced soft tissue sarcomas. In three EORTC protocols, the same dose-schedule was used for patients randomised to treatment with doxorubicin as a single agent (75 mg/m2 every third... | ['Doxorubicin', 'Humans', 'Mitosis', 'Prognosis', 'Retrospective Studies', 'Sarcoma', 'Soft Tissue Neoplasms'] | 8,484,969 | [['D02.455.426.559.847.562.050.200.175', 'D04.615.562.050.200.175', 'D09.408.051.059.200.175'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G04.144.220.220.781', 'G05.113.220.781'], ['E01.789'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', '... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
The association between physical fitness and academic achievement in Texas state house legislative districts: an ecologic study. | BACKGROUND: The association of physical fitness with cognitive function in children and adolescents is unclear. The purpose of this ecological study was to describe the association between academic achievement, body mass index (BMI), and cardiovascular fitness (CVF) in a large sample of elementary, middle, and high sch... | ['Adolescent', 'Body Mass Index', 'Child', 'Cognition', 'Educational Measurement', 'Educational Status', 'Female', 'Humans', 'Male', 'Physical Fitness', 'Texas'] | 25,040,122 | [['M01.060.057'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['M01.060.406'], ['F02.463.188'], ['I02.399'], ['N01.824.196'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G11.427.685', 'I03.450.642.845.054.800', 'N01.400.545'], ['Z01.107.567.875.760.750']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Hypoxia-inducible factor-1alpha promotes nonhypoxia-mediated proliferation in colon cancer cells and xenografts. | Hypoxia-inducible factor-1alpha (HIF-1alpha) is a transcription factor that directly transactivates genes important for the growth and metabolism of solid tumors. HIF-1alpha is overexpressed in cancer, and its level of expression is correlated with patient mortality. Increased synthesis or stability of HIF-1alpha can b... | ['Animals', 'Cell Growth Processes', 'Cell Hypoxia', 'Cell Survival', 'Colonic Neoplasms', 'DNA, Neoplasm', 'Female', 'Glycolysis', 'HCT116 Cells', 'Humans', 'Hypoxia-Inducible Factor 1, alpha Subunit', 'Mice', 'Mice, Nude', 'Transplantation, Heterologous', 'Vascular Endothelial Growth Factor A'] | 16,452,228 | [['B01.050'], ['G04.161', 'G07.345.249.410'], ['G03.197.300', 'G04.270.300'], ['G04.346'], ['C04.588.274.476.411.307.180', 'C06.301.371.411.307.180', 'C06.405.249.411.307.180', 'C06.405.469.158.356.180', 'C06.405.469.491.307.180'], ['D13.444.308.425'], ['G02.111.158.750', 'G03.191.750', 'G03.295.436', 'G03.493.360'], [... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Prospective evaluation of Doppler sonography to detect the twinkling artifact versus unenhanced computed tomography for identifying urinary tract calculi. | OBJECTIVES: The twinkling artifact is an emerging tool for identifying urinary tract calculi. The purpose of this prospective study was to evaluate the diagnostic accuracy of the twinkling artifact compared to unenhanced computed tomography in detecting urolithasis.METHODS: After Research Ethics Board approval, 51 pati... | ['Adult', 'Aged', 'Aged, 80 and over', 'Artifacts', 'Contrast Media', 'Female', 'Humans', 'Male', 'Middle Aged', 'Prospective Studies', 'Reproducibility of Results', 'Sensitivity and Specificity', 'Tomography, X-Ray Computed', 'Ultrasonography, Doppler', 'Urinary Calculi'] | 23,011,625 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.047'], ['D27.505.259.500', 'D27.720.259'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['E05.318.370.725', 'E05.337.851', 'N05.715.36... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A novel balloon colonoscope detects significantly more simulated polyps than a standard colonoscope in a colon model. | BACKGROUND: Although standard colonoscopy is considered the optimal test to detect adenomas, it can have a significant adenoma miss rate. A major contributing factor to high miss rates is the inability to visualize adenomas behind haustral folds and at anatomic flexures.OBJECTIVE: To compare the diagnostic yield of bal... | ['Adult', 'Attitude of Health Personnel', 'Clinical Competence', 'Colon', 'Colonic Polyps', 'Colonoscopes', 'Colonoscopy', 'Equipment Design', 'Female', 'Gastroenterology', 'Humans', 'Male', 'Middle Aged', 'Models, Anatomic', 'Prospective Studies'] | 24,929,483 | [['M01.060.116'], ['F01.100.050', 'N05.300.100'], ['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['A03.556.124.526.356', 'A03.556.249.249.356'], ['C23.300.825.411.235'], ['E07.230.220.260.160', 'E07.858.240.260.160'], ['E01.370.372.250.250.200', 'E01.370.388.250.250.250.160', 'E04.210.240.250.160', 'E04.502.250.250... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Technology, Industry, and A... | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
Diagnosis and treatment of venous leg ulcers. | Treatment for venous leg ulcers has been extensively researched and well defined. The primary care practitioner who is able to recognize and appropriately treat these patients can help prevent months and sometimes years of suffering. | ['Chronic Disease', 'Compression Bandages', 'Debridement', 'Edema', 'Humans', 'Varicose Ulcer', 'Vascular Surgical Procedures', 'Wound Infection'] | 21,088,564 | [['C23.550.291.500'], ['E07.101.400'], ['E04.176'], ['C23.888.277'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.927.730', 'C17.800.893.592.730'], ['E04.100.814'], ['C01.947']] | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Role of Serotonin Transporter in Antidepressant-Induced Diabetes Mellitus: A Pharmacoepidemiological-Pharmacodynamic Study in VigiBase® | BACKGROUND: The association between antidepressant exposure and type 2 diabetes mellitus is still debated. Moreover, the pharmacological mechanisms remain unknown.OBJECTIVE: The objective of this study was to investigate this putative relationship with the role of antidepressant pharmacological targets using the 'pharm... | ['Adult', 'Aged', 'Antidepressive Agents', 'Causality', 'Databases, Factual', 'Diabetes Mellitus, Type 2', 'Female', 'Humans', 'Linear Models', 'Male', 'Middle Aged', 'Pharmacoepidemiology', 'Serotonin Plasma Membrane Transport Proteins', 'Serotonin Uptake Inhibitors', 'World Health Organization'] | 29,956,218 | [['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.427.700.122'], ['N05.715.350.200', 'N06.850.490.625'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['C18.452.394.750.149', 'C19.246.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.500', 'E05.318.740.750.425', 'E05.599.835.750', 'N05.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Information Science [L]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 |
Sacral nerve stimulation for faecal incontinence: medium-term follow-up from a single institution. | BACKGROUND: Most studies on sacral nerve stimulation (SNS) are either single-centre with small numbers of patients or multi-centre studies. We present the medium-term follow-up results from a single centre for 127 patients undergoing SNS.METHODS: Consecutive patients treated with SNS for faecal incontinence had preoper... | ['Adult', 'Aged', 'Aged, 80 and over', 'Electric Stimulation Therapy', 'Electrodes, Implanted', 'Fecal Incontinence', 'Female', 'Follow-Up Studies', 'Humans', 'Lumbosacral Plexus', 'Male', 'Middle Aged', 'Patient Satisfaction', 'Prospective Studies', 'Quality of Life', 'Sacrococcygeal Region', 'Treatment Outcome', 'Wou... | 27,193,192 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E02.331', 'E02.779.468', 'E02.831.535.468'], ['E07.305.250.319', 'E07.695.202'], ['C06.405.469.860.300'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A08.80... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]'] | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Applications of a rapid endospore viability assay for monitoring UV inactivation and characterizing arctic ice cores. | We have developed a rapid endospore viability assay (EVA) in which endospore germination serves as an indicator for viability and applied it to (i) monitor UV inactivation of endospores as a function of dose and (ii) determine the proportion of viable endospores in arctic ice cores (Greenland Ice Sheet Project 2 [GISP2... | ['Arctic Regions', 'Bacillus subtilis', 'Spores, Bacterial', 'Ultraviolet Rays'] | 17,021,233 | [['Z01.208'], ['B03.300.390.400.158.218.725', 'B03.353.500.100.218.725', 'B03.510.100.100.218.725', 'B03.510.415.400.158.218.725', 'B03.510.460.410.158.218.725'], ['A11.870.700', 'B05.775.700'], ['G01.358.500.505.650.891', 'G01.590.540.891', 'G01.750.250.650.891', 'G01.750.750.659', 'G01.750.770.578.891', 'G16.500.275.... | ['Geographicals [Z]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Principles of antibiotic usage. | New antibiotics must demonstrate an advantage over older agents with respect to therapeutic efficacy, protection against infection, toxicity, cost, and pharmacokinetic properties before they can be approved for public consumption. In order to use antibiotics properly, we must know more about whether certain organisms a... | ['Aminoglycosides', 'Anti-Bacterial Agents', 'Bacterial Infections', 'Drug Therapy, Combination', 'Humans', 'Kidney', 'Microbial Sensitivity Tests', 'Premedication'] | 6,488,647 | [['D09.408.051'], ['D27.505.954.122.085'], ['C01.150.252'], ['E02.319.310'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A05.810.453'], ['E01.370.225.875.595', 'E05.200.875.595', 'E05.337.550.400'], ['E02.319.703']] | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Soluble components of Utah Valley particulate pollution alter alveolar macrophage function in vivo and in vitro. | Water-soluble extracts of Utah Valley dust (UVD) have been found to cause inflammatory injury of the lung in both humans and rodents. The degree of lung damage found correlated with the metal content in the extracts. In the present study, extracts of a set of UVD PM(10) filters collected over a 3-yr span, varying in to... | ['Adolescent', 'Adult', 'Air Pollutants', 'Apoptosis', 'Bronchoalveolar Lavage Fluid', 'Cell Survival', 'Cells, Cultured', 'Female', 'Flow Cytometry', 'Humans', 'Macrophages, Alveolar', 'Male', 'Metals, Heavy', 'Particle Size', 'Phagocytosis', 'Respiratory Burst', 'Saccharomyces cerevisiae', 'Solubility', 'Utah'] | 10,880,136 | [['M01.060.057'], ['M01.060.116'], ['D27.888.284.101'], ['G04.146.954.035'], ['E05.927.100.500'], ['G04.346'], ['A11.251'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.200.500.386.350', 'E05.242.363.342', 'E05.242.386.350'], ['B01.050.150.900.649.313... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Geographicals [Z]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
Reducing variation in hospital admissions from the emergency department for low-mortality conditions may produce savings. | The emergency department (ED) is now the primary source for hospitalizations in the United States, and admission rates for all causes differ widely between EDs. In this study we used a national sample of ED visits to examine variation in risk-standardized hospital admission rates from EDs and the relationship of this v... | ['Cost Savings', 'Emergency Service, Hospital', 'Health Services Research', 'Hospital Mortality', 'Humans', 'Outcome Assessment, Health Care', 'Patient Admission', 'Risk Assessment', 'United States'] | 25,201,672 | [['N03.219.151.160.200'], ['N02.278.216.500.968.336', 'N02.421.297.195', 'N04.452.442.452.422.336'], ['H01.770.644.145.360', 'N03.349.380', 'N05.425'], ['E05.318.308.985.550.400', 'N01.224.935.698.400', 'N06.850.505.400.975.550.400', 'N06.850.520.308.985.550.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H01... | ['Health Care [N]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
The potential coding utility of intercell cross-correlations in the retina. | The action potentials (impulses) produced by pairs of neighboring retinal ganglion cells often show a tendency either to fire in close temporal synchrony or to avoid temporal synchrony. This cross-correlation (a rate of "coincidences" that differs from that expected by chance) has been exploited as a window into retina... | ['Action Potentials', 'Animals', 'Cell Communication', 'Contrast Sensitivity', 'Goldfish', 'In Vitro Techniques', 'Models, Neurological', 'Photic Stimulation', 'Retinal Ganglion Cells', 'Synaptic Transmission', 'Vision, Ocular'] | 15,372,240 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['B01.050'], ['G04.085'], ['E01.370.380.850.950.500', 'F02.463.593.778.435.110', 'F02.463.593.932.281', 'F02.463.593.932.901.500', 'G14.940.500'], ['B01.050.150.900.493.200.244.248.480'], ['E05.481'], ['E05.599.395.642'], ['E05.723.729'], ['A08.675.650.850.875', '... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Is single-dose NVP relevant in the era of more efficacious PMTCT regimens? Lessons from Zambia. | For almost a decade, single-dose nevirapine (sdNVP) has been proven to be a safe and effective drug for the prevention of mother-to-child transmission (PMTCT) of HIV. With the advent of the use of more efficacious combination therapy strategy in reducing mother-to-child transmission, sdNVP has been relegated as a lower... | ['Anti-HIV Agents', 'Clinical Protocols', 'Developing Countries', 'Disease Transmission, Infectious', 'Drug Resistance, Viral', 'Female', 'HIV', 'HIV Infections', 'Humans', 'Infant, Newborn', 'Nevirapine', 'Patients', 'Perinatal Care', 'Pregnancy', 'Pregnancy Complications, Infectious', 'Primary Health Care', 'Zambia'] | 20,390,495 | [['D27.505.954.122.388.077.088'], ['E02.183', 'N05.715.360.330.125'], ['I01.615.500.300'], ['N06.850.335'], ['G06.225.420', 'G06.920.225', 'G07.690.773.984.269.420'], ['B04.820.650.589.650.350'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Named Groups [M]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Envelope composition and antibiotic hypersensitivity of Escherichia coli mutants defective in phosphatidylserine synthetase. | Mutants of Escherichia coli K12, defective in phosphatidylserine synthetase (pss), can be isolated as temperature-sensitive, conditional lethals. When cultivated at intermediate temperatures (30 degrees), such mutants contain approximately 3 times more phosphatidylglycerol plus cardiolipin (and less phosphatidylethanol... | ['Anti-Bacterial Agents', 'CDPdiacylglycerol-Serine O-Phosphatidyltransferase', 'Cell Division', 'Cell Membrane', 'Escherichia coli', 'Genotype', 'Kinetics', 'Membrane Proteins', 'Mutation', 'Novobiocin', 'Phosphotransferases', 'Species Specificity'] | 195,963 | [['D27.505.954.122.085'], ['D08.811.913.696.900.150'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.284.149'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['G05.380'], ['G01.374.661', 'G02.111.490'], ['D12.776.543'], ['G05.365.590'], ['D03.383.663.283.446.139.500', 'D03.63... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Unusual distribution of Zfy and Zfx sequences on the sex chromosomes of the wood lemming, a species exhibiting XY sex reversal. | Sex reversal occurs naturally in the wood lemming (Myopus schisticolor) due to the presence in populations of this species of a variant (mutated) X chromosome, designated X*. Thus, X*Y animals develop into females, whereas XY animals develop into normal males. Chromosome mapping by in situ hybridization of DNA sequence... | ['Animals', 'Arvicolinae', 'Blotting, Northern', 'Blotting, Southern', 'Cells, Cultured', 'DNA Probes', 'Disorders of Sex Development', 'Female', 'Male', 'Polymorphism, Restriction Fragment Length', 'X Chromosome', 'Y Chromosome', 'Zinc Fingers'] | 1,349,859 | [['B01.050'], ['B01.050.150.900.649.313.992.635.075'], ['E05.196.401.095', 'E05.301.300.074', 'E05.601.100'], ['E05.196.401.114', 'E05.301.300.087', 'E05.601.150'], ['A11.251'], ['D13.444.600.223', 'D27.505.259.750.600.223', 'D27.720.470.530.600.223'], ['C12.706.316', 'C13.351.875.253', 'C16.131.939.316', 'C19.391.119'... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Characterization of isolated ventricular myocytes from adult zebrafish (Danio rerio). | The zebrafish is widely used for human related disease studies. Surprisingly, there is no information about the electrical activity of single myocytes freshly isolated from adult zebrafish ventricle. In this study, we present an enzymatic method to isolate ventricular myocytes from zebrafish heart that yield a large nu... | ['Action Potentials', 'Animals', 'Calcium Channels', 'Cell Separation', 'Cell Shape', 'Electrophysiology', 'Heart Ventricles', 'Muscle Cells', 'Patch-Clamp Techniques', 'Sodium Channels', 'Ventricular Function', 'Zebrafish'] | 18,602,892 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['B01.050'], ['D12.776.157.530.400.150', 'D12.776.543.550.450.150', 'D12.776.543.585.400.150'], ['E01.370.225.500.363', 'E05.200.500.363', 'E05.242.363'], ['G04.320'], ['H01.158.344.528', 'H01.158.782.236'], ['A07.541.560'], ['A11.620'], ['E05.200.500.905', 'E05.2... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Critical Thinking Disposition of Nurse Practitioners in Taiwan. | BACKGROUND: Critical thinking disposition (CTD) is crucial for nurse practitioners who face complex patient care scenarios. This study explored the CTD of nurse practitioners and related factors.METHOD: The study was a cross-sectional descriptive design. A purposive sample was recruited from a medical center and its ho... | ['Adult', 'Cross-Sectional Studies', 'Curriculum', 'Education, Nursing, Continuing', 'Female', 'Humans', 'Male', 'Middle Aged', 'Nurse Practitioners', 'Surveys and Questionnaires', 'Taiwan', 'Thinking'] | 28,850,660 | [['M01.060.116'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['I02.158'], ['I02.358.212.450', 'I02.358.462.399'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['M01.526.485.650.640', 'N02.360.650.640'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Chronic axonal neuropathy with triosephosphate isomerase deficiency. | A patient with triosephosphate isomerase deficiency resulting from compound heterozygote mutation is described. Chronic axonal neuropathy was identified on clinical and neurophysiologic grounds and confirmed by sural nerve biopsy. This report describes the first biopsy-proven case confirming that peripheral neuropathy ... | ['Axons', 'Child', 'Chronic Disease', 'Humans', 'Male', 'Peripheral Nervous System Diseases', 'Triose-Phosphate Isomerase'] | 14,984,912 | [['A08.675.542.145', 'A11.284.180.075', 'A11.671.137', 'A11.671.501.145'], ['M01.060.406'], ['C23.550.291.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.668.829'], ['D08.811.399.475.200.775']] | ['Anatomy [A]', 'Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The chondrodystrophy, nanomelia: biosynthesis and processing of the defective aggrecan precursor. | The lethal chicken mutation nanomelia leads to severe skeletal defects because of a deficiency of aggrecan, which is the largest aggregating chondroitin sulphate proteoglycan of cartilage. In previous work, we have demonstrated that nanomelic chondrocytes produce a truncated aggrecan precursor that fails to be secreted... | ['Aggrecans', 'Amino Acid Sequence', 'Animals', 'Cartilage', 'Cartilage Diseases', 'Cells, Cultured', 'Chick Embryo', 'Endoplasmic Reticulum', 'Extracellular Matrix', 'Extracellular Matrix Proteins', 'Genes, Lethal', 'Lectins, C-Type', 'Molecular Sequence Data', 'Mutation', 'Poultry Diseases', 'Protein Biosynthesis', '... | 8,037,674 | [['D09.698.735.200.500', 'D12.776.395.650.750.687.100', 'D12.776.503.280.437.100', 'D12.776.860.300.140'], ['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['A02.165', 'A10.165.382'], ['C05.182', 'C17.300.182'], ['A11.251'], ['A13.350.150', 'A16.331.200'], ['A11.284.430.214.190.875.248'], ['A11.284.295.310'], [... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Renal function and cardiovascular outcomes after living donor nephrectomy in the UK: quality and safety revisited. | OBJECTIVE: To determine renal function and cardiovascular outcomes after living donor nephrectomy (LDN). Living donor kidney transplantation has become established as the treatment of choice for end-stage renal failure. Benefits to the recipient have to be balanced against perioperative and long-term health risks to th... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Cardiovascular Diseases', 'Female', 'Glomerular Filtration Rate', 'Humans', 'Kidney Diseases', 'Kidney Transplantation', 'Living Donors', 'Male', 'Middle Aged', 'Nephrectomy', 'Prospective Studies', 'Tissue and Organ Harvesting', 'United Kingdom', 'Young Adult'] | 23,795,791 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C14'], ['E01.370.390.400.300', 'G08.852.357'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.777.419', 'C13.351.968.419'], ['E02.870.500', 'E04.936.450.485', 'E04.950.774.400'], ['M01.898.656'], ['M01.060.116.630'], ['E04.950.77... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Perceptions of sober living houses among addiction counselors and mental health therapists: knowledge, views and perceived barriers. | Affordable alcohol- and drug-free housing that supports recovery is limited in many areas. Sober living houses (SLHs) offer a unique living environment that supports abstinence and maintenance of a recovery lifestyle. Previous studies show that SLH residents make improvements on alcohol, drug and other problems that ar... | ['Alcoholism', 'Behavior, Addictive', 'Community Mental Health Services', 'Counseling', 'Environment', 'Female', 'Halfway Houses', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Male', 'Mental Health', 'Middle Aged', 'Perception', 'Pilot Projects', 'Social Support'] | 23,061,322 | [['C25.775.100.250', 'F03.900.100.350'], ['F01.145.527.100.120'], ['F04.408.307', 'N02.421.143.183', 'N02.421.461.232'], ['F02.784.176', 'F04.408.413', 'N02.421.143.303', 'N02.421.461.363'], ['G16.500.275', 'N06.230'], ['J03.775.450'], ['F01.100.150.500', 'N05.300.150.410'], ['B01.050.150.900.649.313.988.400.112.400.40... | ['Diseases [C]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 |
Resolved abdominal aortic aneurysms following stent graft treatment: a report of five cases. | Complete aneurysm resolution is the hallmark of successful endoluminal stent-graft treatment. We describe 5 patients in whom an abdominal aortic aneurysm (AAA) disappeared completely at mid-term follow-up after endovascular stent-graft placement. We reviewed 45 patients (43 men and 2 women) who underwent AAA repair usi... | ['Aged', 'Aortic Aneurysm, Abdominal', 'Female', 'Follow-Up Studies', 'Humans', 'Lumbosacral Region', 'Male', 'Mesenteric Artery, Inferior', 'Middle Aged', 'Stents', 'Time', 'Tomography, X-Ray Computed', 'Treatment Outcome', 'Vascular Patency'] | 15,259,809 | [['M01.060.116.100'], ['C14.907.055.239.075', 'C14.907.109.139.075'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A01.923.176.519'], ['A07.015.114.565.510'], ['M01.060.116.630'], ['E07.695.750'], ['G01.910'], ['E01.370.350... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Evaluation of longitudinal and radial two-dimensional strain imaging versus Doppler tissue echocardiography in predicting long-term response to cardiac resynchronization therapy. | INTRODUCTION: Cardiac resynchronization therapy (CRT) leads to hemodynamic and clinical improvement in patients with heart failure. This study compares the new technique of 2-dimensional (2D) strain imaging with Doppler tissue imaging (DTI) in the prediction of the long-term response to CRT.METHODS: In all, 38 patients... | ['Aged', 'Defibrillators, Implantable', 'Echocardiography', 'Echocardiography, Doppler', 'Electric Countershock', 'Female', 'Follow-Up Studies', 'Heart Failure', 'Humans', 'Male', 'Middle Aged', 'Myocardial Contraction', 'ROC Curve', 'Stroke Volume', 'Time Factors', 'Treatment Outcome', 'Ventricular Function, Left'] | 17,400,111 | [['M01.060.116.100'], ['E07.305.250.159.175', 'E07.305.250.319.175', 'E07.695.202.175'], ['E01.370.350.130.750', 'E01.370.350.850.220', 'E01.370.370.380.220'], ['E01.370.350.130.750.220', 'E01.370.350.850.220.220', 'E01.370.350.850.850.220', 'E01.370.370.380.220.220'], ['E02.331.350'], ['E05.318.372.500.750.249', 'N05.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
High degree of heterogeneity of PD-L1 and PD-1 from primary to metastatic endometrial cancer. | OBJECTIVE: PD-L1 and PD-1 are predictive markers for immunotherapy and increasingly relevant in endometrial cancer. The reported fraction of positive primary tumors has been inconsistent. We investigated the expression of PD-L1 and PD-1 in primary tumors, also stratified by MSI. As immunotherapy is foremost relevant fo... | ['Aged', 'B7-H1 Antigen', 'Endometrial Neoplasms', 'Female', 'Humans', 'Immunohistochemistry', 'Neoplasm Metastasis', 'Neoplasm Staging', 'Prognosis', 'Programmed Cell Death 1 Receptor', 'RNA, Messenger', 'Transcriptome'] | 31,973,911 | [['M01.060.116.100'], ['D12.776.465.625', 'D12.776.467.150.300', 'D12.776.543.095.300', 'D23.050.301.285.400', 'D23.529.168.300'], ['C04.588.945.418.948.585', 'C13.351.500.852.762.200', 'C13.351.937.418.875.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Associations of body mass index with incident hypertension in American white, American black and Chinese Asian adults in early and middle adulthood: the Coronary Artery Risk Development in Young Adults (CARDIA) study, the Atherosclerosis Risk in Communities (ARIC) study and the People's Republic of China (PRC) study. | The association of body mass index (BMI) with blood pressure may be stronger in Asian than non-Asian populations, however, longitudinal studies with direct comparisons between ethnicities are lacking. We compared the relationship of BMI with incident hypertension over approximately 9.5 years of follow-up in young (24-3... | ['Adult', 'African Americans', 'Asian Americans', 'Body Mass Index', 'China', 'Coronary Artery Disease', 'European Continental Ancestry Group', 'Female', 'Humans', 'Hypertension', 'Male', 'Middle Aged', 'Risk Factors', 'United States'] | 24,231,024 | [['M01.060.116'], ['M01.686.508.100.100', 'M01.686.754.100'], ['M01.686.508.200.100', 'M01.686.754.225'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['Z01.252.474.164'], ['C14.280.647.250.260', 'C14.907.137.126.339', 'C14.907.585.250.260'], ['M01.686.508.400'], ['B01.0... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Geographicals [Z]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
A comparison of gait with solid, dynamic, and no ankle-foot orthoses in children with spastic cerebral palsy. | BACKGROUND AND PURPOSE: This study compared the effects of dynamic ankle-foot orthoses (DAFOs) with a plantar-flexion stop, polypropylene solid ankle-foot orthoses (AFOs), and no AFOs on the gait of children with cerebral palsy (CP). These orthoses were used to reduce the excessive ankle plantar flexion during the stan... | ['Analysis of Variance', 'Cerebral Palsy', 'Child', 'Child, Preschool', 'Electromyography', 'Equipment Design', 'Female', 'Foot', 'Gait', 'Humans', 'Male', 'Muscle Contraction', 'Muscle Spasticity', 'Orthotic Devices'] | 9,105,342 | [['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['C10.228.140.140.254'], ['M01.060.406'], ['M01.060.406.448'], ['E01.370.405.255', 'E01.370.530.255'], ['E05.320'], ['A01.378.610.250'], ['E01.370.600.250', 'G11.427.410.568.900.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G11.427.494'], [... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Named Groups [M]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
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