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Influence of dose and fiber type on respiratory malignancy risk in asbestos cement manufacturing. | This investigation provides information concerning the risk or respiratory malignancy in relation to duration, degree, and fiber type of exposure to asbestos in a manufacturing cohort of 5,645 with long-term follow-up. Excess mortality for this cause was found in groups with moderate and high cumulative exposure (stand... | ['Aged', 'Asbestos', 'Dust', 'Environmental Exposure', 'Follow-Up Studies', 'Humans', 'Louisiana', 'Lung Neoplasms', 'Male', 'Middle Aged', 'Occupational Diseases', 'Risk', 'Time Factors'] | 475,155 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Inflicted skeletal injury: a postmortem radiologic-histopathologic study in 31 infants. | OBJECTIVE: The objective of this postmortem study was to use high-detail skeletal surveys, specimen radiography, and histopathologic analysis to determine the number, distribution, and age of inflicted skeletal injuries in infants studied at the University of Massachusetts Medical Center from 1984 to 1994.MATERIALS AND... | ['Autopsy', 'Child Abuse', 'Fractures, Bone', 'Humans', 'Infant', 'Infant, Newborn', 'Radiography', 'Rib Fractures', 'Wound Healing'] | 7,645,487 | [['E01.370.060', 'E05.070', 'I01.198.780.937.120'], ['I01.198.240.856.350.250', 'I01.880.735.900.350.250'], ['C26.404'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['E01.370.350.700'], ['C26.404.593', 'C26.891.733'], ['G16.762.891']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Cloning, sequencing and expression analysis of the NAR promoter activated during hyphal stage of Magnaporthe grisea. | The promoter of NAR gene in Magnaporthe grisea was isolated and sequenced. The promoter sequences contained the "TATA" box, the "CAAT" box, and binding sites for fungal regulatory proteins. Programs that predict promoter sequences indicated that promoter sequence lies between locations 430 and 857 of the NAR promoter f... | ['Base Sequence', 'Cloning, Molecular', 'Fungal Proteins', 'Gene Expression', 'Hyphae', 'Magnaporthe', 'Molecular Sequence Data', 'Promoter Regions, Genetic', 'Transcriptional Activation'] | 17,726,747 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.393.220'], ['D12.776.354'], ['G05.297'], ['A19.687.400'], ['B01.300.107.575'], ['L01.453.245.667'], ['G02.111.570.080.689.675', 'G05.360.080.689.675', 'G05.360.340.024.340.137.750.680'], ['G05.308.800']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Papers published by members of the Croatian Academy of Medical Sciences, registered in international bibliographic data bases in the period 1986-1990. | Scientific productivity of the CAMS members was analyzed according to the number of papers published in periodicals covered by international Medline and Science Citation Index data bases from 1986 to 1990. Results showed the mean scientific productivity per CAMS member, and the relationship between scientific productiv... | ['Bibliometrics', 'Croatia', 'Databases, Bibliographic', 'Humans'] | 7,488,835 | [['L01.178.682.099.325', 'L01.453.183.291'], ['Z01.542.248.295'], ['L01.313.500.750.300.188.300', 'L01.470.750.500'], ['B01.050.150.900.649.313.988.400.112.400.400']] | ['Information Science [L]', 'Geographicals [Z]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 |
Dirty ducting poses significant risks. | Richard Norman, managing director of ventilation system cleaning specialist Indepth Hygiene, discusses the importance of ensuring that such systems are properly cleaned in healthcare facilities, especially, he argues, as dust and debris on internal surfaces of ducting are potentially "ideal nutrients" for the growth of... | ['Conservation of Energy Resources', 'Hospitals, Public', 'Maintenance and Engineering, Hospital', 'Risk Assessment', 'United Kingdom', 'Ventilation'] | 20,597,385 | [['N06.230.080.078'], ['N02.278.421.510'], ['N02.278.216.500.968.450', 'N02.628.472', 'N04.452.442.452.422.450'], ['E05.318.740.600.800.715', 'N04.452.871.715', 'N05.715.360.750.625.700.690', 'N06.850.505.715', 'N06.850.520.830.600.800.715'], ['Z01.542.363'], ['N06.230.150.520']] | ['Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
The different roles of hRAD50 in microsatellite stable and unstable colorectal cancers. | RAD50 protein is essential for DNA double-strand break repair and maintaining genomic integrity. In this study, we investigated the clinicopathological significance of hRAD50 expression and mutation in microsatellite stable (MSS) and unstable (MSI) colorectal cancers (CRCs). hRAD50 expression was examined in primary CR... | ['Acid Anhydride Hydrolases', 'Adult', 'Aged', 'Colorectal Neoplasms', 'DNA Breaks, Double-Stranded', 'DNA Repair Enzymes', 'DNA-Binding Proteins', 'Female', 'Humans', 'Intestinal Mucosa', 'Male', 'Microsatellite Instability', 'Middle Aged'] | 18,219,098 | [['D08.811.277.040'], ['M01.060.116'], ['M01.060.116.100'], ['C04.588.274.476.411.307', 'C06.301.371.411.307', 'C06.405.249.411.307', 'C06.405.469.158.356', 'C06.405.469.491.307', 'C06.405.469.860.180'], ['G05.200.210.220'], ['D08.811.074'], ['D12.776.260'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A03.556.12... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A novel cyclin gene from Drosophila complements CLN function in yeast. | In the yeast Saccharomyces cerevisiae three G1-S cyclins, or CLNs, have been identified that trigger the G1-S transition of the cell cycle. The regulation of the G1-S transition is particularly intriguing in Drosophila both because G1 is added to the cell cycle developmentally and G1-S regulators may drive the polytene... | ['Amino Acid Sequence', 'Animals', 'Base Sequence', 'Cell Cycle', 'Cloning, Molecular', 'Cyclins', 'DNA', 'Drosophila', 'Genetic Complementation Test', 'Genetic Vectors', 'Genomic Library', 'Molecular Sequence Data', 'Saccharomyces cerevisiae'] | 1,836,192 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G04.144'], ['E05.393.220'], ['D12.644.360.262', 'D12.776.167.218', 'D12.776.476.262'], ['D13.444.308'], ['B01.050.500.131.617.720.500.500.750.310.250'], ['E05.393.281.526'], ['G05.360.337'], ['G05.360.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Residues in Na(+) channel D3-S6 segment modulate both batrachotoxin and local anesthetic affinities. | Batrachotoxin (BTX) alters the gating of voltage-gated Na(+) channels and causes these channels to open persistently, whereas local anesthetics (LAs) block Na(+) conductance. The BTX and LA receptors have been mapped to several common residues in D1-S6 and D4-S6 segments of the Na(+) channel alpha-subunit. We substitut... | ['Amino Acid Sequence', 'Amino Acid Substitution', 'Anesthetics, Local', 'Animals', 'Batrachotoxins', 'Cell Line', 'Humans', 'Ion Channel Gating', 'Membrane Potentials', 'Models, Molecular', 'Molecular Sequence Data', 'Muscle, Skeletal', 'Mutagenesis, Site-Directed', 'Patch-Clamp Techniques', 'Protein Structure, Second... | 10,969,000 | [['G02.111.570.060', 'L01.453.245.667.060'], ['E05.393.420.601.035', 'G05.558.109'], ['D27.505.696.277.100.200', 'D27.505.696.663.850.025', 'D27.505.954.427.210.100.200'], ['B01.050'], ['D20.888.033.112', 'D23.946.833.033.112'], ['A11.251.210'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.111.820.400', 'G04.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Memory improvement by post-trial injection of lidocaine into the tuberomammillary nucleus, the source of neuronal histamine. | Brain histamine is exclusively contained within and released from neurons whose cell bodies are clustered in the tuberomammillary nucleus (TM) of the posterior hypothalamus. This experiment examined the effects of a transient inactivation of the TM on inhibitory avoidance learning. Rats with chronically implanted cannu... | ['Anesthetics, Local', 'Animals', 'Avoidance Learning', 'Histamine Release', 'Hypothalamus, Posterior', 'Lidocaine', 'Male', 'Mammillary Bodies', 'Mental Recall', 'Microinjections', 'Rats', 'Rats, Wistar', 'Reaction Time'] | 10,438,648 | [['D27.505.696.277.100.200', 'D27.505.696.663.850.025', 'D27.505.954.427.210.100.200'], ['B01.050'], ['F02.463.425.097', 'F02.463.785.373.173'], ['G12.350'], ['A08.186.211.180.497.362', 'A08.186.211.200.317.357.362'], ['D02.065.199.092.500', 'D02.092.146.113.092.500'], ['A08.186.211.180.497.362.500', 'A08.186.211.200.3... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Relative mitochondrial membrane potential and [Ca2+]i in type I cells isolated from the rabbit carotid body. | 1. In the accompanying paper (Duchen & Biscoe, 1992) we have described graded changes in autofluorescence derived from mitochondrial NAD(P)H in type I cells of the carotid body in response to changes of PO2 over a physiologically significant range. These observations suggest that mitochondrial function in these cells i... | ['Animals', 'Calcium', 'Carotid Body', 'Cells, Cultured', 'Electron Transport', 'Fluorescence', 'Membrane Potentials', 'Mitochondria', 'Oxygen Consumption', 'Partial Pressure', 'Rabbits', 'Rhodamine 123', 'Rhodamines'] | 1,432,712 | [['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['A08.675.650.915.500.600.150', 'A08.800.950.500.600.150', 'A11.671.650.915.500.600.150'], ['A11.251'], ['G02.111.248', 'G03.295.531.403', 'G03.493.350'], ['G01.358.500.505.650.665.500', 'G01.590.540.665.500'], ['G01.154.535', 'G04.580', 'G07.265.675'... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A 7.5-year prospective study of longer than 18 months type-specific human papillomavirus persistence in a routine cytology-based cervical screening population of about 31,000 women in West Germany. | The objective of this study was to analyse the prevalence, infection pattern, duration and outcome of long-term, type-specific, persistent human papillomavirus (HPV) infections in a routine cytology-based cervical screening population of West German women followed up for 7.5 years. From a screening population of 31,000... | ['Adult', 'Aged', 'Cohort Studies', 'Cytological Techniques', 'Early Detection of Cancer', 'Female', 'Follow-Up Studies', 'Germany, West', 'Humans', 'Mass Screening', 'Middle Aged', 'Papillomaviridae', 'Papillomavirus Infections', 'Prospective Studies', 'Vaginal Smears'] | 19,436,214 | [['M01.060.116'], ['M01.060.116.100'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E01.370.225.500', 'E05.200.500', 'E05.242'], ['E01.390.500'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['Z01.586.350'], ['B01.050.150.900.649.313.988.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
One-step Negative Chromatographic Purification of Helicobacter pylori Neutrophil-activating Protein Overexpressed in Escherichia coli in Batch Mode. | Helicobacter pylori neutrophil-activating protein (HP-NAP) is a major virulence factor of Helicobacter pylori (H. pylori). It plays a critical role in H. pylori-induced gastric inflammation by activating several innate leukocytes including neutrophils, monocytes, and mast cells. The immunogenic and immunomodulatory pro... | ['Bacterial Proteins', 'Chromatography', 'Escherichia coli', 'Helicobacter pylori', 'Monocytes', 'Neutrophils'] | 27,404,433 | [['D12.776.097'], ['E05.196.181'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['B03.440.500.550', 'B03.660.150.235.500.250.550'], ['A11.118.637.555.652', 'A11.148.580', 'A11.627.624', 'A11.733.547', 'A15.145.229.637.555.652', 'A15.378.316.580', 'A15.382.490.555.652', 'A15.382.670.547', 'A15.382.680.547'], ... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Small doses of the resin Colestid in the treatment of hyperlipoproteinemia]. | To a group of 24 subjects with hypercholesterolaemia (hyperlipoproteinaemia type II) for a period of three months the non-absorbable resin Colestid was administered in order to reduce levels of atherogenic lipids and lipoproteins. The Colestid doses were graded from 5 g in the first month to 10-15 g during the third mo... | ['Colestipol', 'Female', 'Humans', 'Hyperlipoproteinemia Type II', 'Lipids', 'Male', 'Middle Aged'] | 2,004,412 | [['D02.092.782.200', 'D05.750.200', 'D25.720.200', 'J01.637.051.720.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C16.320.565.398.481', 'C18.452.584.500.500.644.475', 'C18.452.648.398.481'], ['D10'], ['M01.060.116.630']] | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Diseases [C]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 |
Correlates of dietary resilience among socioeconomically disadvantaged adolescents. | BACKGROUND/OBJECTIVES: Despite increased risk for unhealthy diets, some socioeconomically disadvantaged adolescents manage to consume a healthy diet, thereby showing 'dietary resilience'. This investigation aimed to describe the vegetable and fruit intakes of socioeconomically disadvantaged adolescents, and explore the... | ['Adolescent', 'Adolescent Behavior', 'Child', 'Cross-Sectional Studies', 'Diet', 'Feeding Behavior', 'Female', 'Fruit', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Internet', 'Male', 'Malnutrition', 'Nutrition Surveys', 'Resilience, Psychological', 'Risk', 'Social Networking', 'Socioeconomic Factors', 'Vegetab... | 21,697,821 | [['M01.060.057'], ['F01.145.022'], ['M01.060.406'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['G07.203.650.240'], ['F01.145.113.547', 'F01.145.407', 'G07.203.650.353'], ['A18.024.500', 'G07.203.300.562', 'J02.500.562'], ['F01.100.150.500', 'N05.300.150.410'], ['B01.050.150.900.649.... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Information Science [L]', 'Diseases [C]', 'Anthropology, Education... | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 |
Pulmonary oxygen uptake and muscle deoxygenation kinetics during heavy intensity cycling exercise in patients with emphysema and idiopathic pulmonary fibrosis. | BACKGROUND: Little is known about the mechanistic basis for the exercise intolerance characteristic of patients with respiratory disease; a lack of clearly defined, distinct patient groups limits interpretation of many studies. The purpose of this pilot study was to investigate the pulmonary oxygen uptake ([Formula: se... | ['Adaptation, Physiological', 'Aged', 'Case-Control Studies', 'Exercise Test', 'Exercise Tolerance', 'Female', 'Heart Rate', 'Humans', 'Idiopathic Pulmonary Fibrosis', 'Kinetics', 'Male', 'Middle Aged', 'Muscle, Skeletal', 'Oxygen Consumption', 'Pilot Projects', 'Pulmonary Emphysema', 'Pulmonary Gas Exchange', 'Regress... | 28,143,453 | [['G07.025', 'G16.012.500'], ['M01.060.116.100'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['E01.370.370.380.250', 'E01.370.386.700.250', 'E05.333.250'], ['G11.427.680.270'], ['E01.370.600.875.500', 'G09.330.380.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C08.381.765.... | ['Phenomena and Processes [G]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Ultra-sensitive microfluidic wearable strain sensor for intraocular pressure monitoring. | Wearable technologies have potential to transform healthcare by providing continuous measurements of physiological parameters. Sensors that passively monitor physiological pressure without using electronic components are ideal for wearable contact lenses because they are easy to interface with the cornea and the extern... | ['Animals', 'Equipment Design', 'Intraocular Pressure', 'Lab-On-A-Chip Devices', 'Monitoring, Physiologic', 'Stress, Mechanical', 'Swine', 'Wearable Electronic Devices'] | 30,276,409 | [['B01.050'], ['E05.320'], ['G14.440'], ['E07.305.343.500'], ['E01.370.520'], ['G01.374.835'], ['B01.050.150.900.649.313.500.880'], ['E07.305.906']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Recombination-suppression: how many mechanisms for chromosomal speciation? | Over the past decade several theoretical and empirical studies have revived interest in the role of chromosomes in speciation. The resulting models do not suffer from the problems experienced by previously proposed mechanisms of chromosomal speciation, because they invoke suppression of recombination rather than a redu... | ['Animals', 'Chromosomes', 'Gene Rearrangement', 'Genetic Speciation', 'Models, Genetic', 'Phylogeography', 'Recombination, Genetic', 'Suppression, Genetic'] | 21,327,492 | [['B01.050'], ['A11.284.187', 'A11.284.430.106.279.345.190', 'G05.360.162'], ['G05.344'], ['G05.045.350', 'G16.075.350'], ['E05.599.395.397'], ['H01.158.273.343.335.500', 'H01.277.500.589'], ['G05.728'], ['G05.365.590.835', 'G05.558.835']] | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Influence of oxygen enriched gases during decompression on bubble formation and endothelial function in self-contained underwater breathing apparatus diving: a randomized controlled study. | AIM: To assess the effect of air, gas mixture composed of 50% nitrogen and 50% oxygen (nitrox 50), or gas mixture composed of 1% nitrogen and 99% oxygen (nitrox 99) on bubble formation and vascular/endothelial function during decompression after self-contained underwater breathing apparatus diving.METHODS: This randomi... | ['Adult', 'Air', 'Brachial Artery', 'Decompression', 'Decompression Sickness', 'Diving', 'Endothelium, Vascular', 'Female', 'Humans', 'Male', 'Middle Aged', 'Nitrogen', 'Oxygen', 'Ultrasonography', 'Vasodilation'] | 31,187,955 | [['M01.060.116'], ['G16.500.275.063.150', 'N06.230.300.100.150'], ['A07.015.114.139'], ['E02.278', 'G01.374.715.250'], ['C26.120.248'], ['I03.450.642.845.945.500.110', 'N06.230.150.150'], ['A07.015.700.500', 'A10.272.491.355'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['D01.268.604', 'D01.3... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Thalidomide attenuates graft arteriosclerosis of aortic transplant in a rat model. | OBJECTIVE: The purpose of the current study was to evaluate the effects of thalidomide on graft arteriosclerosis.MATERIALS AND METHODS: Male Lewis rats received abdominal aorta grafts from male Brown-Norway rats. The animals were divided into 4 groups: no treatment controls, a low-dose group that received thalidomide (... | ['Animals', 'Aorta', 'Arteriosclerosis', 'Blotting, Western', 'Disease Models, Animal', 'Enzyme-Linked Immunosorbent Assay', 'Immunohistochemistry', 'Male', 'Rats', 'Rats, Inbred Lew', 'Thalidomide'] | 21,693,319 | [['B01.050'], ['A07.015.114.056'], ['C14.907.137.126'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'],... | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Tetrandrine induces G1/S cell cycle arrest through the ROS/Akt pathway in EOMA cells and inhibits angiogenesis in vivo. | Tetrandrine, a bisbenzylisoquinoline alkaloid, is known to inhibit tumor cell proliferation and induce apoptosis in cancer models in vitro and in vivo. In the present study, tetrandrine significantly inhibited the proliferation of mouse endothelial cells (EOMA cell) and induced G1/S arrest in EOMA cells, in which the e... | ['Animals', 'Antineoplastic Agents, Phytogenic', 'Benzylisoquinolines', 'Cells, Cultured', 'Endothelial Cells', 'G1 Phase Cell Cycle Checkpoints', 'Humans', 'Male', 'Mice', 'Mice, Inbred BALB C', 'Mice, Nude', 'Neovascularization, Pathologic', 'Oncogene Protein v-akt', 'Reactive Oxygen Species', 'Signal Transduction', ... | 25,355,542 | [['B01.050'], ['D27.505.954.248.179'], ['D03.132.098', 'D03.633.100.531.085'], ['A11.251'], ['A11.436.275'], ['G04.144.109.249', 'G04.144.500.320.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.338', 'B01.050.150.900.649.313.992.635.505.500.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Copy number variation of individual cattle genomes using next-generation sequencing. | Copy number variations (CNVs) affect a wide range of phenotypic traits; however, CNVs in or near segmental duplication regions are often intractable. Using a read depth approach based on next-generation sequencing, we examined genome-wide copy number differences among five taurine (three Angus, one Holstein, and one He... | ['Animals', 'Cattle', 'Chromosome Mapping', 'Chromosomes, Mammalian', 'Comparative Genomic Hybridization', 'DNA Copy Number Variations', 'Fatty Acid-Binding Proteins', 'Female', 'Gene Dosage', 'Gene Duplication', 'Genome', 'Genomics', 'In Situ Hybridization, Fluorescence', 'Male', 'Polymerase Chain Reaction', 'Sequence... | 22,300,768 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['E05.393.183'], ['A11.284.187.520', 'G05.360.162.520'], ['E05.393.285.240', 'E05.393.520.500', 'E05.393.661.187'], ['G05.365.795.297.500'], ['D12.776.157.170'], ['G05.380.350'], ['G05.365.590.320', 'G05.558.320'], ['G05.360.340'], ['H01.158.273.180.350', 'H01.158.... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Evaluation of melt granulation and ultrasonic spray congealing as techniques to enhance the dissolution of praziquantel. | Praziquantel (PZQ), an anthelminthic drug widely used in developing countries, is classified in Class II in the Biopharmaceutics Classification Systems; this means that PZQ has very low water solubility and high permeability, thus the dissolution is the absorption rate-limiting factor. The aim of this work was to evalu... | ['Calorimetry, Differential Scanning', 'Chemistry, Pharmaceutical', 'Drug Compounding', 'Fats', 'Nanoparticles', 'Oils', 'Particle Size', 'Pharmaceutical Solutions', 'Poloxamer', 'Polyethylene Glycols', 'Powders', 'Praziquantel', 'Solubility', 'Spectroscopy, Fourier Transform Infrared', 'Ultrasonics', 'X-Ray Diffractio... | 16,697,539 | [['E05.196.131.310', 'E05.196.370.310'], ['H01.158.703.007', 'H01.181.466'], ['E05.916.270'], ['D10.212'], ['J01.637.512.600'], ['D10.627'], ['G02.712'], ['D26.776.708', 'D27.505.954.578', 'D27.720.752'], ['D02.033.455.250.700.682', 'D05.750.741.667', 'D25.720.741.667', 'J01.637.051.720.741.667'], ['D02.033.455.250.700... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Tuning the regio- and stereoselectivity of C-H activation in n-octanes by cytochrome P450 BM-3 with fluorine substituents: evidence for interactions between a C-F bond and aromatic ð systems. | We employed the water-soluble cytochrome P450 BM-3 to study the activity and regiospecificity of oxidation of fluorinated n-octanes. Three mutations, A74G, F87V, and L188Q, were introduced into P450 BM-3 to allow the system to undergo n-octane oxidation. In addition, the alanine at residue 328 was replaced with a pheny... | ['Cytochrome P-450 Enzyme System', 'Electron Transport', 'Flavin Mononucleotide', 'Flavin-Adenine Dinucleotide', 'Fluorine', 'Hydrocarbons, Fluorinated', 'Hydrogen Bonding', 'Hydroxylation', 'Molecular Conformation', 'Mutagenesis', 'Octanes', 'Oxidation-Reduction', 'Solubility', 'Stereoisomerism', 'Water'] | 21,400,620 | [['D08.244.453', 'D08.811.682.690.708.170', 'D12.776.422.220.453'], ['G02.111.248', 'G03.295.531.403', 'G03.493.350'], ['D03.633.100.733.315.650.500', 'D03.633.300.507.650.500', 'D08.211.474.650.500', 'D13.695.827.349', 'D23.767.405.650.500'], ['D03.633.100.733.315.650.249', 'D03.633.100.759.646.138.506', 'D03.633.300.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Estimation of the teratogenic effects of therapeutic drugs]. | Therapeutics may induce embryological abnormalities in the laboratory animal, Now, it is known from experience that the currently applied experimental procedures allow to detect potential teratogenic risks in animals. There is only a slight possibility that a new therapeutic would be highly teratogenic as very special ... | ['Abnormalities, Drug-Induced', 'Animals', 'Animals, Laboratory', 'Drug-Related Side Effects and Adverse Reactions'] | 7,258,038 | [['C16.131.042'], ['B01.050'], ['B01.050.050.199'], ['C25.100']] | ['Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Can postal prompts from general practitioners improve the uptake of breast screening? A randomised controlled trial in one east London general practice. | OBJECTIVE: To determine the effect on the uptake of breast screening of a personalized letter from the general practitioner recommending mammography, sent to coincide with an invitation from the NHS breast screening programme.DESIGN: Randomised control trial with stratification of prognostic variables.SETTING: A group ... | ['Family Practice', 'Female', 'Humans', 'London', 'Mammography', 'Mass Screening', 'Outcome Assessment, Health Care', 'Patient Compliance', 'Postal Service', 'Reminder Systems'] | 9,575,461 | [['H02.403.340.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.433.553', 'Z01.542.363.300.553'], ['E01.370.350.700.500'], ['E01.370.500', 'E05.318.308.980.438.580', 'N02.421.726.233.443', 'N05.715.360.300.800.438.500', 'N06.850.520.308.980.438.580', 'N06.850.780.500'], ['H01.770.644.145.431', 'N04.761.559... | ['Disciplines and Occupations [H]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 |
Evaluation of anti-diabetic and anti-tumoral activities of bioactive compounds from Phoenix dactylifera L's leaf: In vitro and in vivo approach. | Among various chronic disorders, cancer and diabetes mellitus are the most common disorders. This study was designed to evaluate the effectiveness of hydroalcoholic extract of Phoenix dactylifera L. leaves (HEPdL) in animal models of type II diabetes in vitro/in vivo and in a human melanoma-derived cell line (IGR-39). ... | ['Animals', 'Antineoplastic Agents', 'Cell Death', 'Cell Line, Tumor', 'Chromatography, Liquid', 'Diabetes Mellitus, Experimental', 'Diabetes Mellitus, Type 2', 'Enzyme Assays', 'Humans', 'Hyperglycemia', 'Hypoglycemic Agents', 'Male', 'Mice', 'Phoeniceae', 'Phytochemicals', 'Phytotherapy', 'Plant Extracts', 'Plant Lea... | 27,668,542 | [['B01.050'], ['D27.505.954.248'], ['G04.146'], ['A11.251.210.190', 'A11.251.860.180'], ['E05.196.181.400'], ['C18.452.394.750.074', 'C19.246.240', 'E05.598.500.374'], ['C18.452.394.750.149', 'C19.246.300'], ['E05.196.427'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C18.452.394.952'], ['D27.505.696.422'], ['B0... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
New insights into amylose and amylopectin biosynthesis in rice endosperm. | How various isoforms of rice-starch biosynthesis enzymes interact during amylose and amylopectin synthesis is explored. The chain-length distributions of amylopectin and amylose from 95 varieties with different environmental and genetic backgrounds were obtained using size- exclusion chromatography, and fitted with bio... | ['1,4-alpha-Glucan Branching Enzyme', 'Amylopectin', 'Amylose', 'Edible Grain', 'Endosperm', 'Oryza', 'Plant Proteins', 'Starch Synthase'] | 31,887,861 | [['D08.811.913.400.450.460.100'], ['D09.301.915.194', 'D09.698.365.855.194'], ['D09.301.915.361', 'D09.698.365.855.361'], ['A18.024.500.750.500', 'B01.650.160.250', 'B01.650.510.250', 'G07.203.300.300.550', 'G07.203.300.775.500', 'J02.500.300.550', 'J02.500.775.500'], ['A18.024.500.750.666'], ['B01.650.940.800.575.912.... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Pylorus-preserving pancreatoduodenectomy with Billroth I type reconstruction: a viable option for pancreatic head resection. | BACKGROUND/PURPOSE: The aim of this study was to investigate the efficacy of pylorus-preserving pancreatoduodenectomy (PPPD) versus standard pancreatoduodenectomy (PD).METHOD: A cohort of 80 patients were studied for 5 years using prospectively gathered data. PPPD was performed in 48 (60%) patients, and the other 32 (4... | ['Adult', 'Aged', 'Gastrectomy', 'Gastroenterostomy', 'Humans', 'Length of Stay', 'Middle Aged', 'Pancreatic Neoplasms', 'Pancreaticoduodenectomy', 'Postoperative Complications', 'Prospective Studies', 'Pylorus'] | 12,541,049 | [['M01.060.116'], ['M01.060.116.100'], ['E04.210.419'], ['E04.035.398', 'E04.210.457'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.760.400.480', 'N02.421.585.400.480'], ['M01.060.116.630'], ['C04.588.274.761', 'C04.588.322.475', 'C06.301.761', 'C06.689.667', 'C19.344.421'], ['E04.210.760'], ['C23.550.767'],... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Subcellular distribution of nitroblue tetrazolium reductase (NBT-R) in human polymorphonuclear leukocytes (PMN). | Subcellular distribution study of cytoplasmic organelles was performed on human polymorphonuclear leukocytes after homogenization in 0.34 molar sucrose by differential centrifugation and sucrose density gradient centrifugation of the homogenate. The whole homogenate and each fraction was assayed for nitroblue tetrazoli... | ['Acid Phosphatase', 'Alkaline Phosphatase', 'Centrifugation', 'Centrifugation, Density Gradient', 'Glucuronidase', 'Humans', 'Leukocytes', 'Muramidase', 'NADH Tetrazolium Reductase', 'NADH, NADPH Oxidoreductases', 'Nitroblue Tetrazolium', 'Organoids', 'Oxidoreductases', 'Peroxidases'] | 1,185,038 | [['D08.811.277.352.650.025'], ['D08.811.277.352.650.035'], ['E05.181'], ['E05.181.724.336', 'E05.196.941.336'], ['D08.811.277.450.426'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.118.637', 'A15.145.229.637', 'A15.382.490'], ['D08.811.277.450.642'], ['D08.811.682.608.530'], ['D08.811.682.608'], ['D03.383.12... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Photogeneration of the superoxide anion oxygen radical and its role in the inactivation of yeast cells by long-wave UV light]. | Long-wave (320-400 nm) UV-induced oxygen superoxide anion radical (O2-) formation was found in yeast cells. This radical plays an important part in initiation of photodestruction reactions in DNA which serves as a main target of UV irradiation in yeast. The observed cell photoinactivation spectrum at the wavelengths 32... | ['Candida', 'DNA, Fungal', 'Dose-Response Relationship, Radiation', 'Electron Spin Resonance Spectroscopy', 'Free Radicals', 'Mutation', 'Saccharomyces cerevisiae', 'Superoxides', 'Ultraviolet Rays'] | 2,545,760 | [['B01.300.107.795.095', 'B01.300.381.147', 'B01.300.930.176'], ['D13.444.308.300'], ['E05.799.513.500', 'G01.750.740.500', 'G04.712.500', 'G07.225', 'G07.738.500', 'N06.850.810.250.180'], ['E05.196.867.519.274'], ['D01.339', 'D02.389'], ['G05.365.590'], ['B01.300.107.795.785.800', 'B01.300.930.705.655'], ['D01.248.497... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Phytosynthesis of silver nanoparticles using Mangifera indica flower extract as bioreductant and their broad-spectrum antibacterial activity. | The present study focused on the evaluation of antibacterial property of silver nanoparticles (AgNPs) synthesized using mango flower extract. The morphology of the synthesized AgNPs was observed under transmission electron microscopy and the particles have shown spherical shape in the range of 10-20 nm. X-ray powder di... | ['Anti-Bacterial Agents', 'Dose-Response Relationship, Drug', 'Flowers', 'Klebsiella', 'Mangifera', 'Metal Nanoparticles', 'Microbial Sensitivity Tests', 'Molecular Structure', 'Pantoea', 'Particle Size', 'Plant Extracts', 'Rahnella', 'Silver', 'Staphylococcus', 'Structure-Activity Relationship', 'Surface Properties'] | 31,174,009 | [['D27.505.954.122.085'], ['G07.690.773.875', 'G07.690.936.500'], ['A18.024.249.500'], ['B03.440.450.425.425', 'B03.660.250.150.400'], ['B01.650.940.800.575.912.250.044.416'], ['J01.637.512.600.500'], ['E01.370.225.875.595', 'E05.200.875.595', 'E05.337.550.400'], ['G02.111.570', 'G02.466'], ['B03.440.450.425.580', 'B03... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Surgical indication and results in ventricular septal defect associated with severe pulmonary hypertension. | Sixty-four patients with large ventricular septal defects and severe pulmonary hypertension form the basis of this report. Prior to the end of 1970, 35 patients with a ratio of pulmonary to systemic artery pressure (pp/ps) of 0.8 or more were subjected to primary closure of the defect, resulting in 11 operative deaths ... | ['Adolescent', 'Blood Pressure', 'Cardiopulmonary Bypass', 'Child', 'Child, Preschool', 'Heart Murmurs', 'Heart Septal Defects, Ventricular', 'Humans', 'Hypertension, Pulmonary', 'Infant', 'Oxygen', 'Respiration', 'Vascular Resistance'] | 1,245,501 | [['M01.060.057'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E04.292.413'], ['M01.060.406'], ['M01.060.406.448'], ['C23.888.447'], ['C14.240.400.560.540', 'C14.280.400.560.540', 'C16.131.240.400.560.540'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C08.381.423', 'C14.907.489.556'], ['M01.060.703'], ['D01.268... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Design considerations for handling dropouts in anti-depressant drug trials. | BACKGROUND: In clinical trials, statistical analysis often requires certain assumptions about missing data for a valid statistical inference. If the dropout rate is high, a wrong assumption about the missing data may compromise the validity of statistical inferences.PURPOSE: To mitigate the high dropout rates commonly ... | ['Antidepressive Agents', 'Clinical Trials as Topic', 'Depressive Disorder, Major', 'Double-Blind Method', 'Humans', 'Patient Dropouts', 'Research Design', 'Severity of Illness Index', 'Time Factors'] | 29,223,579 | [['D27.505.954.427.700.122'], ['E05.318.372.250.250', 'N05.715.360.330.250.250', 'N06.850.520.450.250.250'], ['F03.600.300.375'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.100.150.750.500.610', 'F01.145.488.887.500.610', ... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Performance Feedback Processing Is Positively Biased As Predicted by Attribution Theory. | A considerable literature on attribution theory has shown that healthy individuals exhibit a positivity bias when inferring the causes of evaluative feedback on their performance. They tend to attribute positive feedback internally (e.g., to their own abilities) but negative feedback externally (e.g., to environmental ... | ['Adult', 'Emotions', 'Facial Expression', 'Feedback, Psychological', 'Female', 'Humans', 'Male', 'Psychological Theory', 'Random Allocation', 'Surveys and Questionnaires', 'Task Performance and Analysis'] | 26,849,646 | [['M01.060.116'], ['F01.470'], ['E01.370.600.225', 'F01.145.209.530.385'], ['F01.058.288', 'F04.754.308'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.739'], ['E05.318.370.700', 'E05.581.500.805', 'N05.715.360.325.675', 'N06.850.520.445.700'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980']... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Increased incidence of axonal Guillain-Barr? syndrome in La Spezia area of Italy: A 13-year follow-up study. | Guillain-Barr? syndrome (GBS) is an acute immune-mediated polyradiculoneuropathy with a worldwide incidence of 0.81-1.89 per 100 000 person-years. In Europe and North America only 5% of patients with GBS have axonal subtypes, which in South America and Asia account for 30%-47% of cases. The aim of our study is to asses... | ['Adult', 'Aged', 'Aged, 80 and over', 'Axons', 'Female', 'Follow-Up Studies', 'Guillain-Barre Syndrome', 'Humans', 'Incidence', 'Italy', 'Male', 'Middle Aged', 'Young Adult'] | 30,421,471 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['A08.675.542.145', 'A11.284.180.075', 'A11.671.137', 'A11.671.501.145'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['C10.114.750.100', 'C10.314.750.450', 'C10.668.829.350', 'C10.668.829.800.750.300', 'C20.1... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Long-term results after the Ross procedure with the decellularized AutoTissue Matrix P® bioprosthesis used for pulmonary valve replacement. | OBJECTIVES: Since 1967, the Ross procedure has been performed to treat aortic valve disease using homografts for pulmonary valve replacement. The decellularized Matrix P® prosthesis was developed to overcome (some) limitations of homografts. Until now, the long-term outcome data have been unavailable.METHODS: Between 2... | ['Adult', 'Aged', 'Aortic Valve', 'Bioprosthesis', 'Echocardiography', 'Female', 'Heart Valve Diseases', 'Heart Valve Prosthesis', 'Heart Valve Prosthesis Implantation', 'Humans', 'Male', 'Middle Aged', 'Pulmonary Valve', 'Reoperation', 'Transplantation, Autologous', 'Treatment Outcome', 'Young Adult'] | 30,508,165 | [['M01.060.116'], ['M01.060.116.100'], ['A07.541.510.110'], ['E07.695.100'], ['E01.370.350.130.750', 'E01.370.350.850.220', 'E01.370.370.380.220'], ['C14.280.484'], ['E07.695.310'], ['E04.100.376.485', 'E04.650.410', 'E04.928.220.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['A07.541.510... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Differential hyperemic responses following femoral arterial and thigh cuff occlusion in the canine hindlimb. | The hyperemic response following arterial reconstruction is variable. To further evaluate this response, arterial blood flows in the canine hindlimb were compared following isolated femoral arterial occlusion and after thigh cuff tourniquet occlusion, which also obstructs collateral circulation. Arterial occlusion and ... | ['Animals', 'Collateral Circulation', 'Constriction', 'Dogs', 'Femoral Artery', 'Hindlimb', 'Hyperemia', 'Regional Blood Flow', 'Time Factors', 'Tourniquets'] | 7,158,859 | [['B01.050'], ['G09.330.100.248'], ['E05.225'], ['B01.050.150.900.649.313.750.250.216.200'], ['A07.015.114.351'], ['A13.473'], ['C14.907.474'], ['G09.330.100.780'], ['G01.910.857'], ['E07.926']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Brown-colored deposits on hair of female rats chronically exposed to 60-Hz electric fields. | An increased incidence and severity of a brownish coloration of hair has been observed around the nose and on the ears of female rats that were chronically exposed to 60-Hz electric fields. Microscopic examination of the colored areas revealed a red-brown globular deposit on hair shafts in affected areas without signs ... | ['Animals', 'Color', 'Electromagnetic Fields', 'Environmental Exposure', 'Female', 'Hair', 'Rats', 'Rats, Inbred Strains'] | 2,268,381 | [['B01.050'], ['G01.590.540.199'], ['G01.358.500.260', 'G01.358.750.500'], ['N06.850.460.350'], ['A17.360'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760', 'B01.050.150.900.649.313.992.635.505.700.400']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Long-term functional outcome in patients with acquired infections after acute spinal cord injury. | OBJECTIVE: To investigate whether prevalent hospital-acquired pneumonia and wound infection affect the clinical long-term outcome after acute traumatic spinal cord injury (SCI).METHODS: This was a longitudinal cohort study within the prospective multicenter National Spinal Cord Injury Database (Birmingham, Alabama). We... | ['Adult', 'Cross Infection', 'Databases, Factual', 'Disability Evaluation', 'Female', 'Follow-Up Studies', 'Hospitalization', 'Humans', 'Longitudinal Studies', 'Male', 'Middle Aged', 'Pneumonia', 'Prevalence', 'Prognosis', 'Prospective Studies', 'Spinal Cord Injuries', 'Surgical Wound Infection', 'Time Factors', 'Treat... | 28,130,472 | [['M01.060.116'], ['C01.248', 'C23.550.291.875.500'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['E01.370.400'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['E02.760.400', 'N02.421.585.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.500.750... | ['Named Groups [M]', 'Diseases [C]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
Trends in and value and consequences of radiologic imaging of perforated gastroduodenal ulcer. A 50-year experience. | The trends in and value and consequences of radiologic imaging in 1128 patients with perforated gastroduodenal ulcer have been studied over the 50-year period 1935-1985. The proportion of patients undergoing plain X-ray studies increased from 4% in the first 5-year period (1935-1939) to 94% in the last (1980-1985). Pne... | ['Adult', 'Aged', 'Aged, 80 and over', 'Contrast Media', 'Female', 'Humans', 'Male', 'Middle Aged', 'Peptic Ulcer Perforation', 'Pneumoperitoneum', 'Radiography', 'Retrospective Studies', 'Time Factors'] | 2,320,943 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.259.500', 'D27.720.259'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C06.405.469.275.800.698', 'C06.405.748.586.698'], ['C06.844.670'], ['E01.370.350.700'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Studies on NADP-+-specific isocitrate dehydrogenase from an extreme thermophile, Thermus flavus AT-62. | 1. NADP-+-specific isocitrate dehydrogenase [EC 1.1.1.42] was partially purified by about 440-fold from an extreme thermophile, Thermus flavus AT-62. 2. Remarkable thermostability of the enzyme was confirmed. The enzyme was not inactivated after 60 min at 70 degrees, and the activity was lost only slowly at 80 degrees.... | ['Bacteria', 'Calorimetry', 'Carboxylic Acids', 'Chromatography, Ion Exchange', 'Drug Stability', 'Glyoxylates', 'Hot Temperature', 'Isocitrate Dehydrogenase', 'Kinetics', 'NAD', 'Oxaloacetates', 'Protein Binding', 'Ribonucleotides', 'Temperature', 'Thermodynamics', 'Time Factors'] | 166,075 | [['B03'], ['E05.196.131'], ['D02.241'], ['E05.196.181.400.383'], ['E05.916.330'], ['D02.241.152.367'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.775.710.380', 'N06.230.300.100.725.232', 'N06.230.300.100.725.710.380'], ['D08.811.682.047.820.475'], ['G01.374.661', 'G02.111.490'], ['D03.633.100.759.6... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Randomized trial of autologous filgrastim-primed bone marrow transplantation versus filgrastim-mobilized peripheral blood stem cell transplantation in lymphoma patients. | Although a large amount of data is available on the effects of filgrastim (granulocyte colony-stimulating factor [G-CSF]) on the mobilization of stem cells in the circulation, data concerning its effects on bone marrow (BM) harvesting is scarce and controversial. We have designed a randomized trial comparing filgrastim... | ['Bone Marrow Transplantation', 'Cell Separation', 'Filgrastim', 'Granulocyte Colony-Stimulating Factor', 'Hematopoietic Stem Cell Transplantation', 'Hodgkin Disease', 'Humans', 'Injections, Subcutaneous', 'Lymphoma, Non-Hodgkin', 'Recombinant Proteins', 'Transplantation, Autologous', 'Treatment Outcome'] | 9,207,435 | [['E02.095.147.725.040', 'E04.936.580.040'], ['E01.370.225.500.363', 'E05.200.500.363', 'E05.242.363'], ['D12.644.276.374.410.240.350.500', 'D12.776.395.240.200.500', 'D12.776.467.374.410.240.350.500', 'D23.529.374.410.240.350.500'], ['D12.644.276.374.410.240.350', 'D12.776.395.240.200', 'D12.776.467.374.410.240.350', ... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Myoepithelioma of the lacrimal gland: report of a case with spindle cell morphology. | The case is described of a 23-year-old female patient presenting with unilateral proptosis, headaches, and transient epiphora. Surgery revealed an encapsulated tumour composed exclusively of spindle-shaped cells within a richly vascularised myxoid stroma. Immunohistochemical staining showed focal positivity for smooth ... | ['Actins', 'Adult', 'Eye Neoplasms', 'Female', 'Glial Fibrillary Acidic Protein', 'Humans', 'Lacrimal Apparatus', 'Myoepithelioma', 'Vimentin'] | 1,329,939 | [['D05.750.078.730.250', 'D12.776.210.500.100', 'D12.776.220.525.255'], ['M01.060.116'], ['C04.588.364', 'C11.319'], ['D05.750.078.593.400', 'D12.776.220.475.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A09.371.463', 'A10.336.422'], ['C04.557.435.585'], ['D05.750.078.593.900', 'D12.776.220.475.900']] | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Natural variation in maize architecture is mediated by allelic differences at the PINOID co-ortholog barren inflorescence2. | We characterized allelic variation at barren inflorescence2 (bif2), a maize co-ortholog of the Arabidopsis PINOID protein kinase (PID), and tested for trait associations with bif2 in both an association mapping population of 277 diverse maize inbreds and in the inter-mated B73 x Mo17 (IBM) linkage population. Results f... | ['Alleles', 'Arabidopsis Proteins', 'Base Sequence', 'DNA, Plant', 'Flowers', 'Gene Expression Regulation, Plant', 'Genes, Plant', 'Genetic Variation', 'Indoleacetic Acids', 'Linkage Disequilibrium', 'Molecular Sequence Data', 'Phenotype', 'Plant Proteins', 'Protein-Serine-Threonine Kinases', 'Quantitative Trait, Herit... | 19,154,226 | [['G05.360.340.024.340.030'], ['D12.776.765.149'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D13.444.308.435'], ['A18.024.249.500'], ['G05.308.375'], ['G05.360.340.024.340.393', 'G05.360.340.365.500'], ['G05.365'], ['D03.066.288', 'D03.633.100.473.404'], ['G05.348.500'], ['L01.453.245.667'], ['G05.69... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Information Science [L]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Expression of Cu/Zn and Mn superoxide dismutases during bovine embryo development: influence of in vitro culture. | Temporal pattern of expression of Cu/Zn and Mn superoxide dismutases (SODs) was investigated in bovine oocytes and embryos produced in vitro in two different culture conditions and in vivo after superovulation. SODs were examined at a transcriptional level in single oocytes and embryos by reverse transcriptase-polymera... | ['Animals', 'Blotting, Western', 'Cattle', 'Cells, Cultured', 'DNA, Complementary', 'Embryonic and Fetal Development', 'Fallopian Tubes', 'Female', 'Free Radical Scavengers', 'In Vitro Techniques', 'RNA, Messenger', 'Reverse Transcriptase Polymerase Chain Reaction', 'Superoxide Dismutase', 'Transcription, Genetic'] | 11,144,220 | [['B01.050'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['B01.050.150.900.649.313.500.380.271'], ['A11.251'], ['D13.444.308.497.220', 'D13.444.600.223.500', 'D27.720.470.530.600.223.260'], ['G07.345.500.325', 'G08.686.784.170'], ['A05.360.319.114.373', 'A13.706... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Exon deletions in the GCHI gene in two of four Turkish families with dopa-responsive dystonia. | Most cases of dopa-responsive dystonia (DRD) are thought to be caused by mutations in the GCHI gene; however, by sequencing, mutations are found in only 40% to 60%. Recently, a single report identified, via Southern blot analysis, a large genomic GCHI deletion in a "mutation-negative" case. This report describes four f... | ['Adult', 'Child', 'DNA', 'Dihydroxyphenylalanine', 'Dopamine Agents', 'Dystonia', 'Exons', 'Female', 'GTP Cyclohydrolase', 'Gene Deletion', 'Gene Dosage', 'Haplotypes', 'Humans', 'Male', 'Pedigree', 'Reverse Transcriptase Polymerase Chain Reaction', 'Turkey'] | 12,473,771 | [['M01.060.116'], ['M01.060.406'], ['D13.444.308'], ['D02.092.311.200', 'D02.455.426.559.389.657.166.175.200', 'D12.125.072.050.685.400', 'D12.125.072.050.875.130'], ['D27.505.519.625.150', 'D27.505.696.577.150'], ['C10.597.350.300', 'C23.888.592.350.300'], ['G05.360.340.024.340.137.232'], ['D08.811.277.151.300'], ['G0... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
The incidence of late prosthetic joint infections: a registry-based study of 112,708 primary hip and knee replacements. | BACKGROUND AND PURPOSE: Late prosthetic joint infections (PJIs) are a growing medical challenge as more and more joint replacements are being performed and the expected lifespan of patients is increasing. We analyzed the incidence rate of late PJI and its temporal trends in a nationwide population.PATIENTS AND METHODS:... | ['Adult', 'Aged', 'Aged, 80 and over', 'Arthroplasty, Replacement, Hip', 'Arthroplasty, Replacement, Knee', 'Female', 'Finland', 'Follow-Up Studies', 'Hip Prosthesis', 'Humans', 'Incidence', 'Knee Prosthesis', 'Male', 'Middle Aged', 'Osteoarthritis, Hip', 'Osteoarthritis, Knee', 'Prosthesis-Related Infections', 'Regist... | 25,813,645 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E04.555.110.110.110', 'E04.650.110.110', 'E04.680.101.110.110'], ['E04.555.110.110.115', 'E04.650.110.115', 'E04.680.101.110.115'], ['Z01.542.816.186'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['E07.695.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Could contrast-enhanced CT detect STEMI prior to electrocardiogram? | We present here a case in which contrast-enhanced computed tomography (CT) was the first diagnostic tool to detect myocardial hypoperfusion in a patient with atypical symptoms and normal electrocardiogram (ECG) on admission. An ST-segment elevation was detected thereafter on a second ECG realized several minutes after ... | ['Contrast Media', 'Diagnosis, Differential', 'Electrocardiography', 'Emergency Service, Hospital', 'Female', 'History, 18th Century', 'Humans', 'Myocardial Infarction', 'Thrombolytic Therapy', 'Tomography, X-Ray Computed'] | 25,085,282 | [['D27.505.259.500', 'D27.720.259'], ['E01.171'], ['E01.370.370.380.240', 'E01.370.405.240'], ['N02.278.216.500.968.336', 'N02.421.297.195', 'N04.452.442.452.422.336'], ['K01.400.504.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.280.647.500', 'C14.907.585.500', 'C23.550.513.355.750', 'C23.550.717.489.75... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Humanities [K]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Human growth hormone binds to lactogenic receptors in bovine, ovine and rat adrenals. | The distribution of 125I radioactivity in the liver, kidneys, adrenals and serum of male rats was measured 10 minutes after an intravenous bolus of 125I-labelled human growth hormone (hGH) was administered in the presence or absence of a large excess of ovine growth hormone or ovine prolactin. The hGH binding sites in ... | ['Adrenal Glands', 'Animals', 'Cattle', 'Growth Hormone', 'In Vitro Techniques', 'Iodine Radioisotopes', 'Kidney', 'Kinetics', 'Liver', 'Male', 'Radioligand Assay', 'Rats', 'Rats, Inbred Strains', 'Receptors, Prolactin', 'Sheep', 'Species Specificity'] | 3,402,911 | [['A06.300.071'], ['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['D06.472.699.631.525.425', 'D12.644.548.691.525.425'], ['E05.481'], ['D01.268.380.400.500.496', 'D01.496.448.496', 'D01.496.749.474'], ['A05.810.453'], ['G01.374.661', 'G02.111.490'], ['A03.620'], ['E01.370.225.985', 'E01.370.374.650', 'E01.370.38... | ['Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Wheat Vacuolar Iron Transporter TaVIT2 Transports Fe and Mn and Is Effective for Biofortification. | Increasing the intrinsic nutritional quality of crops, known as biofortification, is viewed as a sustainable approach to alleviate micronutrient deficiencies. In particular, iron deficiency anemia is a major global health issue, but the iron content of staple crops such as wheat (Triticum aestivum) is difficult to chan... | ['Biofortification', 'Biological Transport', 'Endosperm', 'Flour', 'Gene Expression Regulation, Plant', 'Genome, Plant', 'Iron', 'Manganese', 'Membrane Transport Proteins', 'Phenotype', 'Phytic Acid', 'Plant Development', 'Plant Proteins', 'Plants, Genetically Modified', 'Sequence Homology, Amino Acid', 'Triticum', 'Va... | 28,684,433 | [['J01.040.227.250'], ['G03.143'], ['A18.024.500.750.666'], ['G07.203.300.484', 'J02.500.484'], ['G05.308.375'], ['G05.360.340.365'], ['D01.268.556.412', 'D01.268.956.287', 'D01.552.544.412'], ['D01.268.556.484', 'D01.268.956.374', 'D01.552.544.484'], ['D12.776.157.530', 'D12.776.543.585'], ['G05.695'], ['D02.033.800.5... | ['Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Effect of feeding Sarsaponin in cattle and swine diets. | In four trials, steer calves were received in the feedlot, processed and fed diets supplemented with soybean meal (SBM), 1% urea (UR) or 1% urea plus sarsaponin (S) over a 28-d period. In trials 1 and 2, the feeding period was extended to approximately 62 d, in which steers were fed a common (SBM) diet the last 34 d. I... | ['Animal Feed', 'Animals', 'Body Weight', 'Cattle', 'Female', 'Male', 'Sapogenins', 'Saponins', 'Spirostans', 'Swine'] | 3,610,886 | [['G07.203.300.300.100', 'J02.500.300.100'], ['B01.050'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['B01.050.150.900.649.313.500.380.271'], ['D02.455.849.919.650', 'D04.210.500.795'], ['D09.408.782'], ['D04.210.500.247.515'], ['B01.050.150.900.... | ['Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Midkine is expressed during repair of bone fracture and promotes chondrogenesis. | Midkine (MK) is a heparin-binding growth/differentiation factor implicated in the control of development and repair of various tissues. Upon fracture of the murine tibia, MK was found to be transiently expressed during bone repair. MK was immunohistochemically detected in spindle-shaped mesenchymal cells at the fractur... | ['Aggrecans', 'Animals', 'Animals, Newborn', 'Blotting, Northern', 'Carrier Proteins', 'Cell Line', 'Chondrocytes', 'Chondrogenesis', 'Cytokines', 'DNA, Complementary', 'Embryo, Mammalian', 'Extracellular Matrix Proteins', 'Fracture Healing', 'Growth Plate', 'Immunohistochemistry', 'Lectins, C-Type', 'Limb Buds', 'Mice... | 10,404,013 | [['D09.698.735.200.500', 'D12.776.395.650.750.687.100', 'D12.776.503.280.437.100', 'D12.776.860.300.140'], ['B01.050'], ['B01.050.050.282'], ['E05.196.401.095', 'E05.301.300.074', 'E05.601.100'], ['D12.776.157'], ['A11.251.210'], ['A11.329.171'], ['G07.345.500.325.377.625.180', 'G11.427.578.180'], ['D12.644.276.374', '... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Clinical management and outcome of refractory asthma in the UK from the British Thoracic Society Difficult Asthma Registry. | Refractory asthma represents a significant unmet clinical need. Data from a national online registry audited clinical outcome in 349 adults with refractory asthma from four UK specialist centres in the British Thoracic Society Difficult Asthma Network. At follow-up, lung function improved, with a reduction in important... | ['Administration, Oral', 'Adult', 'Anti-Asthmatic Agents', 'Asthma', 'Delivery of Health Care', 'Drug Administration Schedule', 'Drug Therapy, Combination', 'Female', 'Forced Expiratory Volume', 'Glucocorticoids', 'Hospitalization', 'Humans', 'Male', 'Medical Audit', 'Middle Aged', 'Registries', 'Treatment Outcome', 'V... | 22,581,823 | [['E02.319.267.100'], ['M01.060.116'], ['D27.505.954.796.050'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['N04.590.374', 'N05.300'], ['E02.319.283'], ['E02.319.310'], ['E01.370.386.700.660.230', 'G09.772.650.430'], ['D06.472.040.543', 'D27.505.696.399.472.488'], ['E02.760.400', 'N02.421... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Cocluster analysis of thalamo-cortical fibre tracts extracted from diffusion tensor MRI. | As the central relay station of the human brain, the thalamus modulates sensory signals to and from the cerebral cortex. The reciprocal connectivity between the cerebral cortex and the thalamus is believed to play an essential role in consciousness and various neurological disorders. Thus, in-vivo analysis of thalamo-c... | ['Algorithms', 'Brain', 'Brain Mapping', 'Cerebral Cortex', 'Cluster Analysis', 'Computational Biology', 'Data Interpretation, Statistical', 'Diffusion Magnetic Resonance Imaging', 'Humans', 'Image Processing, Computer-Assisted', 'Models, Genetic', 'Nerve Fibers', 'Nervous System Diseases', 'Neural Pathways', 'Thalamus... | 19,216,341 | [['G17.035', 'L01.224.050'], ['A08.186.211'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['A08.186.211.200.885.287.500'], ['E05.318.740.250', 'N05.715.360.750.200', 'N06.850.520.830.250'], ['H01.158.273.180', 'L01.313.124'], ['E05.245.380', 'E05.318.740.300', 'L01.313.500.750.190.380', '... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
[Surgical treatment of subluxated lens with cataract]. | OBJECTIVE: To study the surgical treatment of the subluxated lens with cataract caused by broken suspensory ligament of the lens.METHODS: Phacoemulsification combined with intraocular lens implantation was performed in 21 eyes. Extracapsular cataract extraction with small-incision was performed in 6 eyes. The visual ac... | ['Aged', 'Cataract Extraction', 'Female', 'Humans', 'Lens Subluxation', 'Male', 'Middle Aged', 'Postoperative Complications', 'Visual Acuity'] | 14,766,065 | [['M01.060.116.100'], ['E04.540.825.249'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C11.510.598'], ['M01.060.116.630'], ['C23.550.767'], ['E01.370.380.850.950', 'F02.463.593.932.901', 'G14.940']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Pain relief from dorsal root entry zone lesions made with argon and carbon dioxide microsurgical lasers. | Argon and carbon dioxide microsurgical lasers were used to produce lesions in the dorsal root entry zone (DREZ) experimentally in six cats and surgically in 21 patients who had denervation pain syndromes. The technique of producing lesions, the histological and physiological changes seen in the cat spinal cord, and the... | ['Adult', 'Animals', 'Argon', 'Carbon Dioxide', 'Cats', 'Evaluation Studies as Topic', 'Female', 'Humans', 'Laser Therapy', 'Male', 'Microsurgery', 'Middle Aged', 'Pain', 'Postoperative Complications', 'Spinal Nerve Roots'] | 6,436,446 | [['M01.060.116'], ['B01.050'], ['D01.268.613.050', 'D01.362.641.113'], ['D01.200.200', 'D01.362.150', 'D01.650.550.200'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['E05.337', 'N05.715.360.335'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.594', 'E04.014.520'], ['E04.494', 'E05.591.580'], ['M01.060.11... | ['Named Groups [M]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Sex differences in white matter alterations following repetitive subconcussive head impacts in collegiate ice hockey players. | Objective: Repetitive subconcussive head impacts (RSHI) may lead to structural, functional, and metabolic alterations of the brain. While differences between males and females have already been suggested following a concussion, whether there are sex differences following exposure to RSHI remains unknown. The aim of thi... | ['Brain Concussion', 'Diffusion Tensor Imaging', 'Female', 'Hockey', 'Humans', 'Image Interpretation, Computer-Assisted', 'Male', 'Sex Characteristics', 'White Matter', 'Young Adult'] | 29,204,342 | [['C10.228.140.199.444.250', 'C10.900.300.087.235.250', 'C10.900.300.350.300', 'C26.915.300.200.194.250', 'C26.915.300.450.500', 'C26.974.382.200'], ['E01.370.350.578.750', 'E01.370.350.825.500.150.500', 'E01.370.376.537.500', 'E05.629.750'], ['I03.450.642.845.475'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Information Science [L]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Named Groups [M]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 |
Combination of herbal components (curcumin, carvacrol, thymol, cinnamaldehyde) in broiler chicken feed: Impacts on response parameters, performance, fatty acid profiles, meat quality and control of coccidia and bacteria. | The objective of this study was to determine whether curcumin and a commercial microencapsulated phytogenic supplement containing thymol, cinnamaldehyde and carvacrol in broiler chicken feed would improve health and meat quality (fatty acid profile), as well as to determine the coccidiostatic and bactericidal potential... | ['Acrolein', 'Animal Feed', 'Animals', 'Bacteria', 'Bacterial Infections', 'Chickens', 'Coccidia', 'Coccidiosis', 'Curcumin', 'Cymenes', 'Dietary Supplements', 'Fatty Acids', 'Meat', 'Poultry Diseases', 'Thymol'] | 31,812,772 | [['D02.047.122'], ['G07.203.300.300.100', 'J02.500.300.100'], ['B01.050'], ['B03'], ['C01.150.252'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['B01.043.075.189'], ['C01.610.752.250'], ['D02.455.326.146.485.222.222', 'D02.455.426.559.389.657.166.200', 'D02.455.426.559.694.222'], ['D02.455.426.559.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Correcting for purifying selection: an improved human mitochondrial molecular clock. | There is currently no calibration available for the whole human mtDNA genome, incorporating both coding and control regions. Furthermore, as several authors have pointed out recently, linear molecular clocks that incorporate selectable characters are in any case problematic. We here confirm a modest effect of purifying... | ['DNA, Mitochondrial', 'Evolution, Molecular', 'Genetic Variation', 'Genome, Human', 'Humans', 'Mitochondria', 'Models, Genetic', 'Mutation', 'Phylogeny', 'Selection, Genetic'] | 19,500,773 | [['D13.444.308.283.225'], ['G05.045.250', 'G16.075.250'], ['G05.365'], ['G05.360.340.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.284.430.214.190.875.564', 'A11.284.835.626'], ['E05.599.395.397'], ['G05.365.590'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['G05.783']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Neonatal back transport: clinical outcomes. | The convalescent course of 55 infants transported from a Level III hospital back to the community hospitals from which they were originally transported was compared with the course of 58 infants who convalesced in the tertiary center nurseries. The events in their prenatal course and acute neonatal course were similar,... | ['Body Weight', 'Convalescence', 'Female', 'Hospitals, Community', 'Humans', 'Infant, Newborn', 'Intensive Care Units, Neonatal', 'Male', 'Oxygen Inhalation Therapy', 'Patient Transfer', 'Prognosis', 'Retrospective Studies', 'Vomiting'] | 3,186,374 | [['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['C23.550.291.562'], ['N02.278.421.306'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['N02.278.388.493.390.380'], ['E02.880.690'], ['E02.760.169.624', 'E02.760.400.630', 'N02.... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Role of Soluble ST2 as a Prognostic Marker in Patients with Acute Heart Failure and Renal Insufficiency. | This study sought to assess the relationship between serum concentrations of the soluble ST2 (sST2) and B-type natriuretic peptide (BNP) and investigate the role of sST2 as a prognosticator in patients hospitalized with acute heart failure (HF) and renal insufficiency. sST2 was measured at admission and discharge in 66... | ['Acute Disease', 'Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Biomarkers', 'Demography', 'Echocardiography', 'Female', 'Follow-Up Studies', 'Glomerular Filtration Rate', 'Heart Failure', 'Hospitalization', 'Humans', 'Immunoassay', 'Interleukin-1 Receptor-Like 1 Protein', 'Male', 'Middle Aged', 'Natriuretic Pep... | 25,931,787 | [['C23.550.291.125'], ['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D23.101'], ['I01.240', 'N01.224', 'N06.850.505.400'], ['E01.370.350.130.750', 'E01.370.350.850.220', 'E01.370.370.380.220'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Location of transpedicular screws for fixation of the lower thoracic and lumbar spine. Computed tomography of 45 fracture cases. | Postoperative CT examinations of an unselected group of 45 patients with fractures of the thoracolumbar and lumbar spine including 1 patient with traumatically activated spondylolisthesis were analyzed for the location of the 200 screws, the angles of insertion, and the screw vs pedicle diameters. In all cases transped... | ['Bone Screws', 'Bone Wires', 'Fracture Fixation', 'Humans', 'Lumbar Vertebrae', 'Spinal Fractures', 'Thoracic Vertebrae', 'Tomography, X-Ray Computed'] | 8,451,940 | [['E07.695.370.437', 'E07.858.442.660.460.437', 'E07.858.690.725.460.437'], ['E07.695.370.468', 'E07.858.442.660.460.468', 'E07.858.690.725.460.468'], ['E04.555.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.232.834.519'], ['C26.117.500.500', 'C26.404.812'], ['A02.835.232.834.892'], ['E01.370.350.350... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The JAM Test and its daughter P-JAM: simple tests of DNA fragmentation to measure cell death and stasis. | Cytotoxic T lymphocytes, and other death-inducing agents, have at least two different ways of killing their targets: drilling holes in the target cell membrane, or triggering the targets to commit suicide. The JAM Test is a method that measures the DNA fragmentation that accompanies cell suicide. We label target cells ... | ['Animals', 'Cell Death', 'Cytotoxicity Tests, Immunologic', 'DNA Fragmentation', 'Mice', 'Sensitivity and Specificity', 'Spleen', 'T-Lymphocytes, Cytotoxic'] | 17,406,295 | [['B01.050'], ['G04.146'], ['E01.370.225.812.160', 'E05.200.812.160', 'E05.478.594.160', 'E05.940.245'], ['G05.200.230'], ['B01.050.150.900.649.313.992.635.505.500'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700', 'N05.715.360.750.725', 'N06.850.520.445.800', 'N06.850.520.830.872'], ['A10.549.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
The relative roles of C4A and C4B in prevention of immune precipitation, solubilisation and immune adherence. | C4A and C4B levels were measured in serum from 246 normal individuals. Complement-mediated solubilisation, assayed using alkaline phosphatase anti-alkaline phosphatase immune complexes (IC), correlated with both C4A and C4B levels. However, C4A and C4B levels showed no correlation with solubilisation of bovine serum al... | ['Antigen-Antibody Complex', 'Complement C4', 'Complement C4a', 'Complement C4b', 'Erythrocytes', 'Hemolysis', 'Humans', 'Immune Adherence Reaction', 'Precipitin Tests', 'Receptors, Complement', 'Serum Albumin', 'Solubility'] | 1,290,020 | [['D12.776.124.486.485.114.257', 'D12.776.124.790.651.114.257', 'D12.776.377.715.548.114.257', 'D23.050.101'], ['D12.776.124.486.274.350'], ['D12.776.124.486.274.024.260', 'D12.776.124.486.274.350.250'], ['D12.776.124.486.274.350.260'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['C23.550.403', 'G12.122.545'], ... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Efficacy and safety data for checkpoint inhibitors in advanced melanoma under real-life conditions: A monocentric study conducted in Nice from 2010 to 2016. | BACKGROUND: Immunotherapies using anti-CTLA4 and anti-PD1 antibodies have revolutionised the management of patients with advanced melanoma. The aim of our study was to analyse the efficacy and safety of immunotherapies in patients with advanced melanoma under real-life conditions.METHODS: We conducted a monocentric, re... | ['Adult', 'Aged', 'Aged, 80 and over', 'Antibodies, Monoclonal, Humanized', 'Antineoplastic Agents, Immunological', 'CTLA-4 Antigen', 'Drug Therapy, Combination', 'Female', 'France', 'Humans', 'Infusions, Intravenous', 'Ipilimumab', 'Male', 'Melanoma', 'Middle Aged', 'Nivolumab', 'Programmed Cell Death 1 Receptor', 'Pr... | 30,098,818 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D12.776.124.486.485.114.224.060', 'D12.776.124.790.651.114.224.060', 'D12.776.377.715.548.114.224.200'], ['D27.505.954.248.384'], ['D12.776.465.782', 'D12.776.543.750.705.222.750', 'D23.050.301.264.894.158', 'D23.101.100.894.158'], ['E02.319.310'], ['Z01... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Ghrelin-induced hippocampal neurogenesis and enhancement of cognitive function are mediated independently of GH/IGF-1 axis: lessons from the spontaneous dwarf rats. | We recently have reported that ghrelin modulates adult hippocampal neurogenesis. However, there is a possibility that the action of ghrelin on hippocampal neurogenesis could be, in part, due to the ability of ghrelin to stimulate the GH/insulin-like growth factor (IGF)-1 axis, where both GH and IGF-1 infusions are know... | ['Acylation', 'Animals', 'Behavior, Animal', 'Biomarkers', 'Cell Proliferation', 'Cognition', 'Dentate Gyrus', 'Ghrelin', 'Growth Hormone', 'Hippocampus', 'Insulin-Like Growth Factor I', 'Male', 'Maze Learning', 'Mutation', 'Nerve Tissue Proteins', 'Neural Stem Cells', 'Neurogenesis', 'Neurons', 'Rats', 'Rats, Mutant S... | 23,774,069 | [['G02.111.012', 'G02.607.063', 'G03.040'], ['B01.050'], ['F01.145.113'], ['D23.101'], ['G04.161.750', 'G07.345.249.410.750'], ['F02.463.188'], ['A08.186.211.180.405.200', 'A08.186.211.200.885.287.500.345.200'], ['D06.472.699.301', 'D12.644.548.322'], ['D06.472.699.631.525.425', 'D12.644.548.691.525.425'], ['A08.186.21... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Genetic association of the NQO1 rs1800566 (609C>T) variant with risk of preeclampsia in the Chinese Han population. | AIMS: The NQO1 gene, located on chromosome 16q22, encodes NAD(P)H dehydrogenase 1, an enzyme that can reduce the production of reactive oxygen species and thereby protect cells from oxidative damage. A functional variant of NQO1, rs1800566 (c.C609T/p.Pro187Ser), has significantly less enzymatic activity. Oxidative imba... | ['Adult', 'Asian Continental Ancestry Group', 'Case-Control Studies', 'China', 'Female', 'Genetic Predisposition to Disease', 'Genotype', 'Humans', 'NAD(P)H Dehydrogenase (Quinone)', 'Polymorphism, Single Nucleotide', 'Pre-Eclampsia', 'Pregnancy', 'Risk Factors'] | 29,153,688 | [['M01.060.116'], ['M01.686.508.200'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['Z01.252.474.164'], ['C23.550.291.687.500', 'G05.380.355'], ['G05.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.682.608.800.500'], ['G05.365.795.598'], ['C13.703.395.249'], ['G08.68... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Inhibition of the CYP3A4-mediated metabolism and P-glycoprotein-mediated transport of the HIV-1 protease inhibitor saquinavir by grapefruit juice components. | AIMS: Cytochrome P450 3A4 (CYP3A4) and P-glycoprotein (P-gp) are both expressed in the intestinal mucosa and present a barrier to oral drug delivery. CYP3A4 and P-gp share both overlapping tissue distribution and substrate specificity. Grapefruit juice interactions with CYP3A4 substrates are well documented and occur a... | ['ATP Binding Cassette Transporter, Subfamily B, Member 1', 'Beverages', 'Caco-2 Cells', 'Citrus', 'Cytochrome P-450 CYP3A', 'Cytochrome P-450 Enzyme System', 'Drug Interactions', 'Gas Chromatography-Mass Spectrometry', 'HIV Protease Inhibitors', 'Humans', 'In Vitro Techniques', 'Ketoconazole', 'Liver', 'Mixed Function... | 10,583,025 | [['D12.776.157.530.100.075.063', 'D12.776.157.530.450.074.500.500.250.125', 'D12.776.395.550.020.400.153', 'D12.776.543.550.192.400.153', 'D12.776.543.585.100.200.125', 'D12.776.543.585.450.074.500.500.250.125'], ['G07.203.100', 'J02.200'], ['A11.251.210.190.160', 'A11.251.860.180.160', 'A11.436.140'], ['B01.650.940.80... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
CNS recurrence following CD34+ peripheral blood stem cell transplantation in stage 4 neuroblastoma. | We report here central nervous system (CNS) recurrence in neuroblastoma (NBL) after CD34(+) peripheral blood stem cell transplantation (PBSCT). Fifteen stage 4 NBL patients underwent CD34(+) transplantation with myeloablative chemotherapy consisting of carboplatin, etoposide, and melphalan. There were three primary sit... | ['Antigens, CD34', 'Antineoplastic Combined Chemotherapy Protocols', 'Brain Neoplasms', 'Child', 'Child, Preschool', 'Female', 'Humans', 'Incidence', 'Infant', 'Korea', 'Male', 'Neuroblastoma', 'Peripheral Blood Stem Cell Transplantation', 'Risk'] | 15,770,641 | [['D23.050.301.264.035.134', 'D23.101.100.110.134'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.85... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Named Groups [M]', 'Organisms [B]', 'Health Care [N]', 'Geographicals [Z]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
[A method of visual representation for the distribution of variables in the Geneva area]. | Using a 10,000 square meter partition of the Geneva area, a computer mapping was developped for the geographical distribution of variables such as population density or pollutants emissions. An example is given in which the method is applied to epidemiological date (age and respiratory performance of a population sampl... | ['Age Factors', 'Air Pollutants', 'Computers', 'Epidemiologic Methods', 'Geography', 'Humans', 'Maps as Topic', 'Methods', 'Population Density', 'Pulmonary Ventilation', 'Switzerland'] | 997,968 | [['N05.715.350.075', 'N06.850.490.250'], ['D27.888.284.101'], ['L01.224.230.260'], ['E05.318', 'N06.850.520'], ['H01.277.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['J01.897.280.500.426', 'L01.178.820.090.426'], ['E05.581'], ['N01.224.600', 'N06.850.505.400.600'], ['E01.370.386.700.660', 'G09.772.650'], ['... | ['Health Care [N]', 'Chemicals and Drugs [D]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 |
Effectiveness of a heated lidocaine/tetracaine topical patch for pain associated with myofascial trigger points: results of an open-label pilot study. | OBJECTIVE: Evaluate potential usefulness of a heated lidocaine/tetracaine topical patch for treatment for pain associated with myofascial trigger points (MTPs).BACKGROUND: Depth and duration of analgesia when patch is used as indicated, on intact skin to provide local dermal analgesia for superficial venous access and ... | ['Adult', 'Aged', 'Anesthetics, Local', 'Drug Combinations', 'Female', 'Hot Temperature', 'Humans', 'Lidocaine', 'Male', 'Middle Aged', 'Myofascial Pain Syndromes', 'Pilot Projects', 'Tetracaine', 'Transdermal Patch', 'Treatment Outcome'] | 23,231,060 | [['M01.060.116'], ['M01.060.116.100'], ['D27.505.696.277.100.200', 'D27.505.696.663.850.025', 'D27.505.954.427.210.100.200'], ['D26.310'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.775.710.380', 'N06.230.300.100.725.232', 'N06.230.300.100.725.710.380'], ['B01.050.150.900.649.313.988.400.112.400.40... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Clinical and laboratory features of acute monocytic leukemia with B lymphoproliferative disorders]. | OBJECTIVE: To identify the clinical and pathological features of acute myeloid leukemia with B lymphoproliferative disorders.METHODS: The characteristics of 3 cases of acute monocytic leukemia with untreated chronic lymphocytic leukemia/monoclonal B-cell lymphocytosis were reported with literatures review.RESULTS: The ... | ['Aged', 'B-Lymphocytes', 'Female', 'Humans', 'Leukemia, Monocytic, Acute', 'Lymphocytosis', 'Middle Aged'] | 23,336,222 | [['M01.060.116.100'], ['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.337.539.275.484'], ['C15.378.553.475.604'], ['M01.060.116.630']] | ['Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Analysis of intra-uterine cytokine concentration and matrix-metalloproteinase activity in women with recurrent failed embryo transfer. | BACKGROUND: In all IVF programmes, some patients fail to achieve an ongoing pregnancy, even after numerous embryo transfer procedures. An unfavourable environment within the uterus might be a contributory factor to such recurrent implantation failure. This question was addressed by measuring cytokine concentrations and... | ['Abortion, Habitual', 'Adult', 'Cytokines', 'Embryo Transfer', 'Female', 'Humans', 'Infertility, Female', 'Interferon-gamma', 'Interleukin-1', 'Interleukin-10', 'Matrix Metalloproteinase 2', 'Matrix Metalloproteinase 9', 'Osmolar Concentration', 'Recurrence', 'Treatment Failure', 'Uterus'] | 12,615,834 | [['C13.703.039.089'], ['M01.060.116'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['E02.875.800.500', 'E05.820.800.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C13.351.500.365.700'], ['D12.644.276.374.440.893', 'D12.644.276.374.480.615.350', 'D12.776.467.374.440.893', 'D12.776.467.374.480.615.3... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Burned-Out Testis Tumors in Asymptomatic Infertile Men: Multiparametric Sonography and MRI Findings. | Multiparametric testicular ultrasound and magnetic resonance imaging (MRI) findings were analyzed in a series of 10 infertile asymptomatic men presenting with pathologically confirmed burned-out testicular tumors. Color/power Doppler ultrasound (CDUS), shear wave elastography (SWE), contrast-enhanced ultrasonography (C... | ['Adult', 'Contrast Media', 'Elasticity Imaging Techniques', 'Humans', 'Image Enhancement', 'Infertility', 'Magnetic Resonance Imaging', 'Male', 'Testicular Neoplasms', 'Testis', 'Ultrasonography', 'Ultrasonography, Doppler, Color'] | 27,914,180 | [['M01.060.116'], ['D27.505.259.500', 'D27.720.259'], ['E01.370.350.850.270'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.600.350', 'L01.224.308.380'], ['C12.294.365', 'C13.351.500.365'], ['E01.370.350.825.500'], ['C04.588.322.762', 'C04.588.945.440.915', 'C12.294.260.937', 'C12.758.409.937', 'C19.3... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Information Science [L]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Seasonal effects of tropical climate on shaded and nonshaded cows as measured by rectal temperature, adrenal cortex hormones, thyroid hormone, and milk production. | Rectal temperatures and hormone concentrations were monitored at intervals of 2 to 3 weeks, and milk, milk fat, and California mastitis test scores at intervals of 1 week in five shaded and in four nonshaded early lactation cows. Measurements were taken from September to December in the mildly heat stressing climate of... | ['Adrenal Cortex Hormones', 'Animals', 'Body Temperature', 'California', 'Cattle', 'Dairy Products', 'Humidity', 'Milk', 'Seasons', 'Sunlight', 'Temperature', 'Thyroid Hormones', 'Tropical Climate'] | 525,903 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Clinical evaluation of four composite resins in posterior teeth. Five-year results. | Four different composite resins (three small particle and one microfill) were placed in 106 posterior teeth and followed over a five-year period. Colour and marginal discoloration characteristics were assessed from standard photographs, and wear evaluated by standardized measurement of cavity wall exposure and scanning... | ['Bisphenol A-Glycidyl Methacrylate', 'Color', 'Composite Resins', 'Dental Restoration, Permanent', 'Evaluation Studies as Topic', 'Humans', 'Materials Testing', 'Microscopy, Electron, Scanning', 'Polymethacrylic Acids', 'Polyurethanes', 'Stress, Mechanical', 'Surface Properties', 'Time Factors'] | 1,836,723 | [['D02.241.081.069.600.150', 'D02.455.426.559.389.657.100', 'D05.750.716.822.308.200', 'D25.339.816.500.200', 'D25.720.716.822.308.200', 'J01.637.051.339.816.500.200', 'J01.637.051.720.716.822.308.200'], ['G01.590.540.199'], ['D05.750.716.822.308', 'D25.339.816.500', 'D25.720.716.822.308', 'J01.637.051.339.816.500', 'J... | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Marijuana effect and delta-9-tetrahydrocannabinol plasma level. | delta-9-Tetrahydrocannabinol (THC) kinetics and dynamics of self-reported psychologic "high" effect are analyzed in six subjects who smoked marijuana cigarettes of three different potencies. Correlation of the pharmacologic response to smoking a marijuana cigarette with plasma THC levels was done with compartmental mod... | ['Cannabis', 'Dronabinol', 'Humans', 'Kinetics'] | 6,086,207 | [['B01.650.940.800.575.912.250.859.937.055.500'], ['D02.455.849.090.810'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.374.661', 'G02.111.490']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A laboratory-based, hospital-wide, electronic marker for nosocomial infection: the future of infection control surveillance? | Faced with expectations to improve patient safety and contain costs, the US health care system is under increasing pressure to comprehensively and objectively account for nosocomial infections. Widely accepted nosocomial infection surveillance methods, however, are limited in scope, not sensitive, and applied inconsist... | ['Cross Infection', 'Disease Notification', 'Humans', 'Illinois', 'Infection Control', 'Intensive Care Units', 'Laboratories, Hospital', 'Medical Records Systems, Computerized', 'Sentinel Surveillance'] | 16,482,989 | [['C01.248', 'C23.550.291.875.500'], ['E05.318.362', 'N06.850.520.373', 'N06.850.780.200.262'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.107.567.875.350.350', 'Z01.107.567.875.510.350'], ['N06.850.780.200.450'], ['N02.278.388.493'], ['N02.278.216.500.968.420', 'N02.278.487.410', 'N04.452.442.452.422.420']... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Information Science [L]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 |
Regional cerebral blood flow-SPECT in chronic alcoholism: relation to neuropsychological testing. | To determine the prevalence of central nervous system damage due to ethanol, we evaluated 40 asymptomatic chronic alcoholics and 20 age-matched controls. Studies included neuropsychological testing, brain 99mTc-HMPAO SPECT, and morphometric analysis by CT scan. In the qualitative analysis, 30 of the 40 alcoholics showe... | ['Adult', 'Alcoholism', 'Atrophy', 'Brain', 'Brain Diseases', 'Cerebrovascular Circulation', 'Frontal Lobe', 'Humans', 'Male', 'Neuropsychological Tests', 'Organotechnetium Compounds', 'Oximes', 'Technetium Tc 99m Exametazime', 'Tomography, Emission-Computed, Single-Photon', 'Tomography, X-Ray Computed'] | 8,355,063 | [['M01.060.116'], ['C25.775.100.250', 'F03.900.100.350'], ['C23.300.070'], ['A08.186.211'], ['C10.228.140'], ['G09.330.100.159'], ['A08.186.211.200.885.287.500.270'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F04.711.513'], ['D02.691.825'], ['D02.092.570.665'], ['D02.092.570.665.810', 'D02.691.825.562'], ['E01... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Influence of compression pressure and die-wall pressure on tablet sticking]. | An eccentric-type tablet machine fitted with 8-mm-diameter flat-faced punches was used to measure the forces of upper and lower punches, die-wall pressure, tablet ejection force, and scraper pressure (SCR), a type of shear stress, to evaluate sticking behavior. The shear stress between the surfaces of the tablet and lo... | ['Chemistry, Physical', 'Drug Compounding', 'Linear Models', 'Pressure', 'Stress, Mechanical', 'Tablets', 'Tensile Strength'] | 21,467,800 | [['H01.181.529'], ['E05.916.270'], ['E05.318.740.500.500', 'E05.318.740.750.425', 'E05.599.835.750', 'N05.715.360.750.530.460', 'N05.715.360.750.695.460', 'N06.850.520.830.500.500', 'N06.850.520.830.750.425'], ['G01.374.715'], ['G01.374.835'], ['D26.255.830'], ['G01.374.850']] | ['Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Ataxia reflected in the simulated movements of patients with cerebellar lesions. | Previous studies demonstrated that the time required to simulate mentally a complex movement is highly correlated with the time required to execute the same task. The purpose of this experiment was to examine whether this relationship exists when execution times are prolonged as a consequence of the motor abnormalities... | ['Adult', 'Arm', 'Cerebellar Ataxia', 'Cerebellum', 'Female', 'Humans', 'Imagination', 'Male', 'Middle Aged', 'Movement', 'Time Factors'] | 9,696,381 | [['M01.060.116'], ['A01.378.800.075'], ['C10.228.140.252.190', 'C10.597.350.090.500', 'C23.888.592.350.090.200'], ['A08.186.211.132.810.428.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.188.634'], ['M01.060.116.630'], ['G07.568', 'G11.427.410'], ['G01.910.857']] | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
X-ray Crystal Structure, Geometric Isomerism, and Antimicrobial Activity of New Copper(II) Carboxylate Complexes with Imidazole Derivatives. | Five new copper(II) acrylate complexes (acr is the acrylate anion: C₃H₃O₂) with imidazole derivatives (2-methylimidazole/2-MeIm, 5-methylimidazole/5-MeIm, 2-ethylimidazole/2-EtIm) of type: cis-[Cu(2-RIm)₂(acr)₂]·xH₂O ((1): R = ⁻CH₃, x = 2; (4): R = ⁻CH₂⁻CH₃, x = 0), trans-[Cu(2-RIm)₂(acr)₂] ((2): R = ⁻CH₃; (5): R = ⁻CH... | ['Anti-Infective Agents', 'Antifungal Agents', 'Bacteria', 'Carboxylic Acids', 'Copper', 'Crystallography, X-Ray', 'Fungi', 'Hydrogen Bonding', 'Imidazoles', 'Isomerism', 'Ligands', 'Microbial Sensitivity Tests', 'Molecular Conformation'] | 30,544,862 | [['D27.505.954.122'], ['D27.505.954.122.136'], ['B03'], ['D02.241'], ['D01.268.556.195', 'D01.268.956.170', 'D01.552.544.195'], ['E05.196.309.742.225'], ['B01.300'], ['G02.282'], ['D03.383.129.308'], ['G02.111.570.685', 'G02.607.445'], ['D27.720.470.480'], ['E01.370.225.875.595', 'E05.200.875.595', 'E05.337.550.400'], ... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Resting-state functional MRI reveals altered brain connectivity and its correlation with motor dysfunction in a mouse model of Huntington's disease. | Huntington's disease (HD) is an autosomal dominant inherited neurodegenerative disorder, and no cure is available currently. Treatment of HD is likely to be most beneficial in the early, possibly pre-manifestation stage. The challenge is to determine the best time for intervention and evaluate putative efficacy in the ... | ['Animals', 'Connectome', 'Corpus Striatum', 'Disease Models, Animal', 'Female', 'Humans', 'Huntington Disease', 'Magnetic Resonance Imaging', 'Male', 'Mice', 'Mice, Transgenic', 'Rest'] | 29,196,686 | [['B01.050'], ['E01.370.350.578.875.500.249', 'E01.370.376.537.625.500.249', 'E05.629.875.500.500'], ['A08.186.211.200.885.287.249.487'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.228.140.079.545', 'C10.228.140.380.278', 'C10.228.662.262.249.750', 'C10.574.500... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
Acute modest changes in relative humidity do not affect energy expenditure at rest in human subjects. | Energy expenditure at rest was determined twice in 10 healthy subjects with a 2-d interval at a relative humidity of 32 and 66 per cent respectively. The relative humidity over the 2 d preceding each observation was estimated to be about 32 per cent. The average (+/- s.e.m.) difference between the RMR at a relative hum... | ['Body Weight', 'Calorimetry, Indirect', 'Energy Metabolism', 'Health Status', 'Humans', 'Humidity', 'Male', 'Rest'] | 3,429,267 | [['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['E05.196.131.655'], ['G03.295'], ['I01.240.425', 'N01.224.425', 'N06.850.505.400.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G16.500.275.063.725.310', 'G16.500.750.775.310', 'N06.230.150.... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
The experiences of behavior interventionists who work with children with autism in families' homes. | This study examined the experiences of 65 behavior interventionists (BIs) who provide 1:1 home-based instruction to children with autism in two Canadian provinces. Dependent variables included occupational stress; the relationships among stress, strain, and coping; the relationship between stress and the characteristic... | ['Adaptation, Psychological', 'Adult', 'Autistic Disorder', 'Child', 'Family', 'Female', 'Health Personnel', 'Humans', 'Male', 'Middle Aged', 'Occupational Diseases', 'Professional-Patient Relations', 'Social Environment', 'Stress, Psychological', 'Surveys and Questionnaires'] | 17,088,274 | [['F01.058'], ['M01.060.116'], ['F03.625.164.113.500'], ['M01.060.406'], ['F01.829.263', 'I01.880.853.150'], ['M01.526.485', 'N02.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C24'], ['F01.829.401.650', 'N05.300.660'], ['I01.880.853.500'], ['F01.145.126.990', 'F02.830.900'], ['E05.318.3... | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Milk loss and treatment costs associated with two treatment protocols for clinical mastitis in dairy cows. | The objective of this study was to compare milk loss and treatment costs for cows with clinical mastitis that were given antibiotics in addition to supportive treatment or supportive treatment alone. Between January 1994 and January 1996, 116,876 daily milk records on 676 lactations were taken at the University of Illi... | ['Animals', 'Anti-Bacterial Agents', 'Cattle', 'Costs and Cost Analysis', 'Dairying', 'Drug Costs', 'Female', 'Lactation', 'Mastitis, Bovine', 'Milk', 'Regression Analysis'] | 15,328,296 | [['B01.050'], ['D27.505.954.122.085'], ['B01.050.150.900.649.313.500.380.271'], ['N03.219.151'], ['J01.040.246'], ['N03.219.151.400.350', 'N05.300.375.300'], ['G08.686.523', 'G08.686.702.500'], ['C22.196.581'], ['A12.200.455', 'A12.790', 'G07.203.100.700', 'G07.203.300.350.525', 'J02.200.700', 'J02.500.350.525'], ['E05... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Spatio-Temporal, Genotypic, and Environmental Effects on Plant Soluble Protein and Digestible Carbohydrate Content: Implications for Insect Herbivores with Cotton as an Exemplar. | Plant soluble protein and digestible carbohydrate content significantly affect insect herbivore fitness, but studies reporting plant protein and carbohydrate content are rare. Instead, the elements nitrogen and carbon often are used as surrogates for plant protein and digestible carbohydrate content, respectively. Howe... | ['Animals', 'Carbohydrate Metabolism', 'Digestion', 'Environment', 'Genotype', 'Gossypium', 'Herbivory', 'Insecta', 'Plant Proteins', 'Solubility', 'Spatio-Temporal Analysis'] | 27,738,861 | [['B01.050'], ['G02.111.158', 'G03.191'], ['G07.203.650.250', 'G10.261.190'], ['G16.500.275', 'N06.230'], ['G05.380'], ['B01.650.940.800.575.912.250.859.821.500.244'], ['F01.145.113.547.600', 'F01.145.407.758', 'G07.203.650.353.758'], ['B01.050.500.131.617'], ['D12.776.765'], ['G02.805'], ['E05.318.740.933.500', 'N05.7... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Characteristics and lasting contributions of 19th-century American neurologists. | This project sought to identify characteristics and lasting contributions of 19th-century members of the American Neurological Association (ANA). Members were categorized by elite status, citation frequency, founder or charter member, elected to honorary membership, published a monograph on a neurologic or psychiatric ... | ['Bibliometrics', 'History, 19th Century', 'History, 20th Century', 'Humans', 'Neurology', 'Publishing', 'Societies, Medical', 'United States'] | 11,512,433 | [['L01.178.682.099.325', 'L01.453.183.291'], ['K01.400.504.937'], ['K01.400.504.968'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H02.403.600'], ['L01.737'], ['N03.540.828.589'], ['Z01.107.567.875']] | ['Information Science [L]', 'Humanities [K]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 |
Estimation of bacterial species phylogeny through oligonucleotide frequency distances. | Classification of bacteria is mainly based on sequence comparisons of certain homologous genes such as 16S rRNA. Recently there are challenges to classify bacteria using oligonucleotide frequency pattern of nonhomologous sequences. However, the evolutionary significance of oligonucleotides longer than tetra-nucleotide ... | ['Bacteria', 'Base Composition', 'Computational Biology', 'Models, Genetic', 'Oligonucleotides', 'Phylogeny', 'RNA, Ribosomal, 16S'] | 19,442,633 | [['B03'], ['G02.111.080'], ['H01.158.273.180', 'L01.313.124'], ['E05.599.395.397'], ['D13.695.578.424'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['D13.444.735.686.670']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Plasma succinylacetone is persistently raised after liver transplantation in tyrosinaemia type 1. | BACKGROUND: Tyrosinaemia type 1 (HT1) is a rare disorder leading to accumulation of toxic metabolites such as succinylacetone (SA) and a high risk of hepatocellular carcinoma. Children with HT1 traditionally required liver transplantation (OLT) and while the need for this has been reduced by the introduction of nitisin... | ['Adolescent', 'Child', 'Child, Preschool', 'Cyclohexanones', 'Heptanoates', 'Humans', 'Infant', 'Liver Transplantation', 'Nitrobenzoates', 'Porphobilinogen Synthase', 'Retrospective Studies', 'Tyrosinemias'] | 22,456,946 | [['M01.060.057'], ['M01.060.406'], ['M01.060.406.448'], ['D02.455.426.392.368.367.340', 'D02.522.400'], ['D10.251.450.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['E02.095.147.725.490', 'E04.210.650', 'E04.936.450.490', 'E04.936.580.490'], ['D02.241.223.100.600', 'D02.455.426.559.389.127.65... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Effects of antisense oligodeoxynucleotides to NR1 on suppression of seizures and protection of cortical neurons from excitotoxicity in vivo and in vitro. | OBJECTIVE: To investigate the effects of NR1 subunit on the initiation and development of seizures and protection of cortical neurons from excitotoxicity by using antisense oligodeoxynucleotides (ODN) to NR1 in vivo and in vitro.METHODS: Intracerebroventricular injection, temporal cortex slices discharge, cerebral cort... | ['Animals', 'Cells, Cultured', 'Cerebral Cortex', 'Down-Regulation', 'Epilepsy', 'Excitatory Amino Acids', 'Neurons', 'Oligonucleotides, Antisense', 'Rats', 'Receptors, N-Methyl-D-Aspartate', 'Temporal Lobe'] | 9,594,256 | [['B01.050'], ['A11.251'], ['A08.186.211.200.885.287.500'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['C10.228.140.490'], ['D12.125.427'], ['A08.675', 'A11.671'], ['D13.150.480', 'D13.444.600.150.640', 'D13.695.578.424.480', 'D27.720.470.530.600.150.640'], ['B01.050.150.900.649.313.992.635.505.700'], ['D12.77... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Segregation of CD4 and CXCR4 into distinct lipid microdomains in T lymphocytes suggests a mechanism for membrane destabilization by human immunodeficiency virus. | Recent evidence has suggested that plasma membrane sphingolipids and cholesterol spontaneously coalesce into raft-like microdomains and that specific proteins, including CD4 and some other T-cell signaling molecules, sequester into these rafts. In agreement with these results, we found that CD4 and the associated Lck t... | ['CD4 Antigens', 'CD4-Positive T-Lymphocytes', 'Cell Line', 'HIV Infections', 'HIV-1', 'HeLa Cells', 'Humans', 'Membrane Fusion', 'Membrane Microdomains', 'Microscopy, Confocal', 'Receptors, CXCR4', 'T-Lymphocytes'] | 11,799,176 | [['D12.776.543.750.705.852.420.810.500', 'D12.776.543.750.830.700.025', 'D23.050.301.264.894.100', 'D23.101.100.894.100'], ['A11.118.637.555.567.569.200', 'A15.145.229.637.555.567.569.200', 'A15.382.490.555.567.569.200'], ['A11.251.210'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.61... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Impact of increased access to novel agents on the survival of multiple myeloma patients treated at a single New Zealand centre. | BACKGROUND: The impact of changes in novel agent (NA) usage on the survival of multiple myeloma (MM) patients in real-world hospital settings is unclear. In New Zealand (NZ) in 2011, frontline bortezomib became available and thalidomide availability was expanded.AIM: This retrospective study analyses the impact these c... | ['Adult', 'Aged', 'Aged, 80 and over', 'Antineoplastic Agents', 'Antineoplastic Agents, Alkylating', 'Bortezomib', 'Female', 'Health Services Accessibility', 'Hematopoietic Stem Cell Transplantation', 'Hospitalization', 'Humans', 'Immunosuppressive Agents', 'Induction Chemotherapy', 'Male', 'Melphalan', 'Middle Aged', ... | 30,411,451 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.954.248'], ['D27.505.519.124.035', 'D27.505.954.248.150', 'D27.888.569.035.035'], ['D01.029.260.110.500', 'D01.132.285.500', 'D02.203.200.500', 'D03.383.679.450'], ['N04.590.374.350', 'N05.300.430'], ['E02.095.147.500.500.500', 'E04.936.225.687.5... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Methyl esterification of C-terminal leucine residues in cytosolic 36-kDa polypeptides of bovine brain. A novel eucaryotic protein carboxyl methylation reaction. | Incubation of cytosolic extracts of bovine brain with S-adenosyl[methyl-3H]methionine results in the predominant [3H]methyl esterification of a 36-kDa polypeptide. This reaction appears to be distinct from any of the three known types of protein carboxyl methylation reactions previously established. We show here that t... | ['Amino Acid Sequence', 'Animals', 'Brain', 'Cattle', 'Chromatography, Liquid', 'Cytosol', 'Electrophoresis, Polyacrylamide Gel', 'Esterification', 'Leucine', 'Methylation', 'Molecular Sequence Data', 'Peptides', 'Protein O-Methyltransferase', 'Substrate Specificity'] | 8,514,774 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['A08.186.211'], ['B01.050.150.900.649.313.500.380.271'], ['E05.196.181.400'], ['A11.284.430.214.200', 'A11.284.430.429.200', 'A11.284.835.450.200'], ['E05.196.401.402', 'E05.301.300.319'], ['G02.111.270', 'G02.607.250', 'G03.344'], ['D12.125.070.637', 'D12.125.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Life-cycle toxicity of 4-nonylphenol to medaka (Oryzias latipes). | We studied the chronic effects of 4-nonylphenol (4-NP) on reproductive status of medaka (Oryzias latipes) over two generations of continuous exposure. The exposure study of the parental (F0) medaka was begun on embryos within 24 h postfertilization and continued with monitoring through embryological development, hatchi... | ['Animals', 'Embryo, Nonmammalian', 'Embryonic Development', 'Female', 'Gonads', 'Larva', 'Male', 'Oryzias', 'Phenols', 'Reproduction', 'Sex Differentiation', 'Sex Ratio', 'Survival Analysis', 'Swimming', 'Water Pollutants, Chemical'] | 11,699,782 | [['B01.050'], ['A13.350', 'A16.331'], ['G07.345.500.325.180', 'G08.686.784.170.104'], ['A05.360.576', 'A06.300.312'], ['B05.500.500', 'G07.345.500.550.500.500'], ['B01.050.150.900.493.850.139.650'], ['D02.455.426.559.389.657'], ['G08.686.784'], ['G07.345.500.325.377.843', 'G07.345.750.500', 'G08.686.841.500'], ['G05.81... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Acquired pili torti in two patients treated with synthetic retinoids. | A mother and daughter with epidermolytic hyperkeratosis were treated with two different synthetic retinoids at different times. Both patients exhibited the previously unreported side effect of increased curliness of scalp hair. Light microscopic examination revealed pili torti during the administration of isotretinoin.... | ['Adolescent', 'Adult', 'Female', 'Hair', 'Hair Diseases', 'Humans', 'Isotretinoin', 'Keratosis', 'Tretinoin'] | 3,859,397 | [['M01.060.057'], ['M01.060.116'], ['A17.360'], ['C17.800.329'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.455.326.271.665.202.495.325', 'D02.455.426.392.368.367.379.249.700.325', 'D02.455.849.131.495.325', 'D23.767.261.700.325'], ['C17.800.428'], ['D02.455.326.271.665.202.495.818.500', 'D02.455.426.392.36... | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Protective effect of polysaccharide fractions from Radix A. sinensis against tert-butylhydroperoxide induced oxidative injury in murine peritoneal macrophages. | Three Angelica sinensis polysaccharide fractions (APFs), named APF1, APF2 and APF3, were isolated and purified from Radix A. sinensis and their antioxidant activities were evaluated in isolated mouse peritoneal macrophages by pretreatment with APFs before exposure to 0.2 mM tertbutylhydroperoxide (t-BHP). The results s... | ['Angelica sinensis', 'Animals', 'Antioxidants', 'Cell Survival', 'Glutathione', 'In Vitro Techniques', 'L-Lactate Dehydrogenase', 'Macrophage Activation', 'Macrophages, Peritoneal', 'Mice', 'Mice, Inbred BALB C', 'Nitric Oxide', 'Polysaccharides', 'Protein Binding', 'Reactive Oxygen Species', 'Superoxide Dismutase', '... | 18,047,788 | [['B01.650.940.800.575.912.250.075.088.538'], ['B01.050'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['G04.346'], ['D12.644.456.448'], ['E05.481'], ['D08.811.682.047.551.400', 'D08.811.682.047.820.493'], ['G12.287.500'], ['A11.329.372.630', 'A11.627.482.630', 'A11.733.397.630', 'A15.382.670.522.630... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Advances in fiducial-free image-guidance for spinal radiosurgery with CyberKnife--a phantom study. | The image-guided CyberKnife radiosurgery system is apable of tracking spinal targets without fiducial implants. Recently, a new version of this fiducial-free image guidance modality ("enhanced Xsight spine tracking") has been introduced. We assessed the accuracy of this novel technique versus its precursor in a compara... | ['Algorithms', 'Equipment Design', 'Head and Neck Neoplasms', 'Humans', 'Image Processing, Computer-Assisted', 'Phantoms, Imaging', 'Radiography', 'Radiosurgery', 'Radiotherapy Planning, Computer-Assisted', 'Reproducibility of Results', 'Robotics', 'Spine', 'Surgery, Computer-Assisted', 'X-Rays'] | 21,587,167 | [['G17.035', 'L01.224.050'], ['E05.320'], ['C04.588.443'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['E07.671'], ['E01.370.350.700'], ['E02.815.530', 'E04.525.800.650', 'E05.873.500'], ['E02.950.825', 'L01.313.500.750.100.710.600.608'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', ... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 |
Olfactory function and nasal manifestations of Beh?et's disease. | OBJECTIVE: To investigate the effect of Beh?et's disease on olfactory function, the nasal mucosa, and nasal symptoms.METHODS: A total of 30 patients with Beh?et's disease and 30 healthy individuals volunteered to enroll in the study. Any condition leading to olfactory dysfunction was a criterion for exclusion. Nasal en... | ['Adult', 'Behcet Syndrome', 'Case-Control Studies', 'Endoscopy', 'Epistaxis', 'Female', 'Humans', 'Male', 'Middle Aged', 'Nasal Mucosa', 'Nasal Obstruction', 'Olfaction Disorders', 'Sensory Thresholds', 'Smell', 'Ulcer', 'Young Adult'] | 24,183,397 | [['M01.060.116'], ['C07.465.075', 'C11.941.879.780.880.200', 'C14.907.940.100', 'C16.320.382.250', 'C17.800.827.368.250', 'C17.800.862.150'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['E01.370.388.250', 'E04.502.250'], ['C08.460.261', 'C09.603.261', 'C23.550.414.712', 'C23.888.852.... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Acute appendicitis: influence of early pain relief on the accuracy of clinical and US findings in the decision to operate--a randomized trial. | PURPOSE: To determine the influence of early pain relief on the diagnostic performance of ultrasonography (US) and on the appropriateness of the surgical decision.MATERIALS AND METHODS: A prospective randomized, double-blind placebo-controlled trial with morphine was conducted. A visual analog scale was used to evaluat... | ['Abdominal Pain', 'Acute Disease', 'Adolescent', 'Adult', 'Analgesics, Opioid', 'Appendectomy', 'Appendicitis', 'Confidence Intervals', 'Decision Making', 'Double-Blind Method', 'Female', 'Follow-Up Studies', 'Humans', 'Injections, Intravenous', 'Male', 'Morphine', 'Pain Measurement', 'Patient Discharge', 'Placebos', ... | 10,207,461 | [['C23.888.592.612.054', 'C23.888.821.030'], ['C23.550.291.125'], ['M01.060.057'], ['M01.060.116'], ['D27.505.696.277.600.500', 'D27.505.696.663.850.014.760.500', 'D27.505.954.427.040.550.500', 'D27.505.954.427.210.600.500'], ['E04.210.078'], ['C01.463.099', 'C06.405.205.099', 'C06.405.469.110.207'], ['E05.318.740.275'... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
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