Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Establishing parasegments in Drosophila embryos: roles of the odd-skipped and naked genes. | During Drosophila embryogenesis, a genetic cascade establishes repeating developmental units, the parasegments, along the anterior-posterior axis. Anterior and posterior boundaries of parasegments are defined by narrow stripes of cells expressing the segment polarity genes engrailed and wingless, respectively. Through ... | ['Animals', 'DNA-Binding Proteins', 'Drosophila', 'Drosophila Proteins', 'Fushi Tarazu Transcription Factors', 'Gene Expression Regulation', 'Genes, Insect', 'Genes, Regulator', 'Homeodomain Proteins', 'In Situ Hybridization', 'Insect Hormones', 'Models, Genetic', 'Proto-Oncogene Proteins', 'RNA, Messenger', 'Receptors... | 7,750,646 | [['B01.050'], ['D12.776.260'], ['B01.050.500.131.617.720.500.500.750.310.250'], ['D12.776.093.500.462'], ['D12.776.260.400.155', 'D12.776.930.312'], ['G05.308'], ['G05.360.340.024.340.340', 'G05.360.340.357.500'], ['G05.360.340.024.340.425'], ['D12.776.260.400'], ['E01.370.225.500.620.670.325', 'E01.370.225.750.600.670... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effect of practice variation on resource utilization in infants hospitalized for viral lower respiratory illness. | OBJECTIVE: Hospital care for children with viral lower respiratory illness (VLRI) is highly variable, and its relationship to severity and impact on outcome is unclear. Using the Pediatric Comprehensive Severity Index, we analyzed the correlation of institutional practice variation with severity and resource utilizatio... | ['Bronchiolitis, Viral', 'Female', 'Health Care Costs', 'Health Resources', 'Hospitalization', 'Hospitals, Pediatric', 'Humans', 'Infant', 'Length of Stay', 'Male', "Practice Patterns, Physicians'", 'Respiratory Syncytial Virus Infections', 'Respiratory Tract Infections', 'Severity of Illness Index', 'Virus Diseases'] | 11,581,435 | [['C01.748.099.135.321', 'C01.925.109', 'C08.127.446.135.321', 'C08.381.495.146.135.321', 'C08.730.099.135.321'], ['N03.219.151.400', 'N05.300.375'], ['N03.349.340', 'N05.300.420'], ['E02.760.400', 'N02.421.585.400'], ['N02.278.421.556.437'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['E02.760.4... | ['Diseases [C]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Impact of seagrass establishment, industrialization and coastal infrastructure on seagrass biogeochemical sinks. | The study of a Posidonia sinuosa sedimentary archive has delivered a millenary record of environmental change in Cockburn Sound (Western Australia). Ecosystem change is a major environmental problem challenging sustainable coastal development worldwide, and this study shows baseline trends and shifts in ecological proc... | ['Carbon', 'Ecosystem', 'Geologic Sediments', 'Industrial Development', 'Soil'] | 32,907,728 | [['D01.268.150'], ['G16.500.275.157', 'N06.230.124'], ['G01.311.330', 'G16.500.320'], ['I01.261.262.500', 'J01.576.519'], ['D20.721', 'G01.311.820', 'G16.500.275.815', 'N06.230.600']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 |
The dual role of S-nitrosoglutathione (GSNO) during thymocyte apoptosis. | Nitric oxide (NO) is known to regulate redox-sensitive signalling pathways in physiology and pathophysiology. Depending on its concentration, the NO-releasing compound S-nitrosoglutathione (GSNO) causes negative and positive regulation of thymocyte apoptosis. At levels below 0.6 mM, GSNO produces deoxyribonucleic acid ... | ['Animals', 'Apoptosis', 'Cells, Cultured', 'Cycloheximide', 'DNA Damage', 'Dinitrochlorobenzene', 'Dose-Response Relationship, Drug', 'Egtazic Acid', 'Ethylmaleimide', 'Glutathione', 'Male', 'Nitroso Compounds', 'Protein Kinase C', 'Rats', 'Rats, Sprague-Dawley', 'S-Nitrosoglutathione', 'Tetradecanoylphorbol Acetate',... | 8,736,700 | [['B01.050'], ['G04.146.954.035'], ['A11.251'], ['D03.383.621.808.240'], ['G05.200'], ['D02.455.426.559.389.261.250', 'D02.455.426.559.389.565.250', 'D02.455.526.439.202.200', 'D02.640.529.240.250', 'D23.050.550.480.350'], ['G07.690.773.875', 'G07.690.936.500'], ['D02.092.782.258.368.257', 'D02.241.081.018.269'], ['D02... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Synthesis of 8-aryltetrahydroisoquinolines as dopamine antagonists and evaluation for potential neuroleptic activity. | The synthesis of 8-(methoxyphenyl)-1,2,3,4-tetrahydroisoquinolines using aryloxazolines as key intermediates is described. Nucleophilic displacement on an o-methoxyphenyloxazoline by an aryl Grignard reagent, followed by electrophilic substitution at the other ortho position, provided a specific route to the properly s... | ['Animals', 'Antipsychotic Agents', 'Avoidance Learning', 'Binding, Competitive', 'Cattle', 'Central Nervous System', 'Dopamine', 'Dopamine Antagonists', 'Haloperidol', 'In Vitro Techniques', 'Isoquinolines', 'Male', 'Mice', 'Rats', 'Receptors, Dopamine'] | 6,106,063 | [['B01.050'], ['D27.505.696.277.950.040', 'D27.505.954.427.210.950.040', 'D27.505.954.427.700.872.331'], ['F02.463.425.097', 'F02.463.785.373.173'], ['E05.196.080', 'G02.111.084', 'G02.111.570.120.309'], ['B01.050.150.900.649.313.500.380.271'], ['A08.186'], ['D02.092.211.215.406', 'D02.092.311.342', 'D02.455.426.559.38... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Self-esteem and symptoms of depression in children with seizures: relationships with neuropsychological functioning and family variables over time. | PURPOSE: To test over time the relationships of neuropsychological functioning to mental health in children following a first recognized seizure and, of primary importance, to determine if the strength of these relationships differs based on risk and protective factors.METHODS: In a larger prospective study, 135 childr... | ['Adolescent', 'Age Factors', 'Age of Onset', 'Child', 'Depression', 'Factor Analysis, Statistical', 'Family', 'Female', 'Humans', 'Interviews as Topic', 'Longitudinal Studies', 'Male', 'Neuropsychological Tests', 'Parents', 'Prospective Studies', 'Regression Analysis', 'Seizures', 'Self Concept'] | 20,412,284 | [['M01.060.057'], ['N05.715.350.075', 'N06.850.490.250'], ['N05.715.350.075.100', 'N06.850.490.250.100'], ['M01.060.406'], ['F01.145.126.350'], ['E05.318.740.400', 'N05.715.360.750.350', 'N06.850.520.830.400'], ['F01.829.263', 'I01.880.853.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.420', 'L01... | ['Named Groups [M]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Information Science [L]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 0 |
Migration behavior of metal complexes in capillary zone electrophoresis. Interpretation in terms of quantitative structure-mobility relationships. | Significant advances in metal ion analysis by capillary zone electrophoresis (CZE) have occurred as a consequence of using metal complexes with various organic and inorganic ligands. Metal-ligand complexes that contribute to metal speciation in solution have also gained the attention of researchers. An understanding of... | ['Chelating Agents', 'Electrophoresis, Capillary', 'Metals', 'Quantitative Structure-Activity Relationship'] | 11,833,646 | [['D27.505.519.914.500', 'D27.720.832.500'], ['E05.196.401.190', 'E05.301.300.190'], ['D01.552'], ['G02.111.830.500', 'G07.690.773.997.500']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Association between Kr?ppel like factor 6 intervening sequence 1-27 G > A and cancer susceptibility: A meta-analysis. | Background/Objective: It has been reported that Kr?ppel like factor 6 intervening sequence (KLF6 IVS) 1-27 G > A might be associated with cancer susceptibility. Here, we conducted a meta-analysis to summarize and clarify this association.Materials and Methods/Main Results: A systematic search of studies on the associat... | ['Alleles', 'Female', 'Genetic Association Studies', 'Genetic Predisposition to Disease', 'Genotype', 'Humans', 'Introns', 'Kruppel-Like Factor 6', 'Male', 'Neoplasms', 'Odds Ratio', 'Polymorphism, Single Nucleotide', 'Publication Bias'] | 29,970,714 | [['G05.360.340.024.340.030'], ['E05.393.385'], ['C23.550.291.687.500', 'G05.380.355'], ['G05.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G05.360.340.024.220.400', 'G05.360.340.024.340.137.515'], ['D12.776.260.522.563', 'D12.776.260.755.050', 'D12.776.624.664.700.120', 'D12.776.930.375.563'], ['C04'], ['E0... | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Information Science [L]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
A second base pair interaction between U3 small nucleolar RNA and the 5'-ETS region is required for early cleavage of the yeast pre-ribosomal RNA. | In eukaryotes, U3 snoRNA is essential for pre-rRNA maturation. Its 5'-domain was found to form base pair interactions with the 18S and 5'-ETS parts of the pre-rRNA. In Xenopus laevis, two segments of U3 snoRNA form base-pair interactions with the 5'-ETS region and only one of them is essential to the maturation process... | ['Base Pairing', 'Mutation', 'Phosphoproteins', 'RNA Precursors', 'RNA Processing, Post-Transcriptional', 'RNA, Ribosomal', 'RNA, Ribosomal, 18S', 'RNA, Small Nucleolar', 'Ribonucleoproteins', 'Ribosomal Proteins', 'Saccharomyces cerevisiae', 'Saccharomyces cerevisiae Proteins'] | 21,890,904 | [['G02.111.570.820.486.100', 'G02.111.611.500', 'G05.360.580.100'], ['G05.365.590'], ['D12.776.744'], ['D13.400.730', 'D13.444.735.640'], ['G02.111.760', 'G03.839', 'G05.308.700'], ['D13.444.735.686'], ['D13.444.735.686.675'], ['D13.444.735.628.818.800', 'D13.444.735.790.552.937.800'], ['D12.776.157.725.500', 'D12.776.... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Extra-vascular findings in patients undergoing magnetic resonance angiography of the abdomen, pelvis and lower extremities: A retrospective study of 352 patients. | Background The aim of this study was to assess the prevalence and clinical significance of extra-vascular findings in patients undergoing magnetic resonance angiography of the abdomen, pelvis and lower extremities. Materials and methods Three hundred fifty-two patients underwent abdominal, pelvic and lower extremity 1.... | ['Abdomen', 'Aged', 'Female', 'Humans', 'Incidental Findings', 'Lower Extremity', 'Magnetic Resonance Angiography', 'Male', 'Middle Aged', 'Neoplasms', 'Pelvis', 'Predictive Value of Tests', 'Retrospective Studies', 'Vascular Diseases'] | 28,587,578 | [['A01.923.047'], ['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.410'], ['A01.378.610'], ['E01.370.350.825.500.500', 'E01.370.370.050.500'], ['M01.060.116.630'], ['C04'], ['A01.923.600'], ['E05.318.370.800.650', 'N05.715.360.325.700.640', 'N06.850.520.445.800.650'], ['E05.318.372.500.500.50... | ['Anatomy [A]', 'Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The use of [3H](-)-DO 710 as selective dopaminergic ligand for binding and autoradiographic studies. | DO 710, a benzamide derivative previously shown to display a dopamine antagonistic potency superior to that of sulpiride, was 3H-labeled. Its use as radioligand was assessed in membrane binding and autoradiographic studies. The compound displayed relatively high affinity (Kd 2 nM) and pronounced selectivity for dopamin... | ['Animals', 'Autoradiography', 'Brain', 'Domperidone', 'Freezing', 'In Vitro Techniques', 'Kinetics', 'Ligands', 'Male', 'Rats', 'Rats, Inbred Strains', 'Receptors, Dopamine', 'Spiperone', 'Sulpiride', 'Tritium'] | 3,979,426 | [['B01.050'], ['E01.370.225.750.132', 'E05.200.750.132', 'E05.799.256'], ['A08.186.211'], ['D03.383.621.210', 'D03.633.100.103.370'], ['G01.645.500', 'G01.906.595.272.437', 'G02.734.466'], ['E05.481'], ['G01.374.661', 'G02.111.490'], ['D27.720.470.480'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.52... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Amino acid neurotransmitters in nucleus tractus solitarius: an in vivo microdialysis study. | Amino acid neurotransmitters in the nucleus tractus solitarius (NTS) are thought to play a key role in the mediation of visceral reflexes and glutamate has been proposed as the neurotransmitter of visceral afferent nerves projecting to this region. The present studies sought to characterize the use of in vivo microdial... | ['Afferent Pathways', 'Amino Acids', 'Animals', 'Aspartic Acid', 'Chromatography, High Pressure Liquid', 'Electric Stimulation', 'Glutamates', 'Glutamic Acid', 'Kainic Acid', 'Kinetics', 'Male', 'Membrane Potentials', 'Microdialysis', 'Nerve Endings', 'Neurotransmitter Agents', 'Nodose Ganglion', 'Potassium', 'Rats', '... | 7,902,420 | [['A08.612.220'], ['D12.125'], ['B01.050'], ['D12.125.067.500', 'D12.125.119.170', 'D12.125.427.040'], ['E05.196.181.400.300'], ['E05.723.402'], ['D12.125.067.625', 'D12.125.119.409'], ['D12.125.067.625.349', 'D12.125.119.409.349', 'D12.125.427.300'], ['D03.383.773.400'], ['G01.374.661', 'G02.111.490'], ['G01.154.535',... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
MicroRNA expression profiling reveals the potential function of microRNA-31 in chordomas. | Chordomas are rare bone tumors arising from remnants of the notochord. Molecular studies to determine the pathways involved in their pathogenesis and develop better treatments are limited. Alterations in microRNAs (miRNAs) play important roles in cancer. miRNAs are small RNA sequences that affect transcriptional and po... | ['Apoptosis', 'Biomarkers, Tumor', 'Case-Control Studies', 'Cell Proliferation', 'Chordoma', 'Flow Cytometry', 'Gene Expression Profiling', 'Gene Expression Regulation, Neoplastic', 'Humans', 'MicroRNAs', 'Oligonucleotide Array Sequence Analysis', 'Real-Time Polymerase Chain Reaction', 'Reverse Transcriptase Polymerase... | 23,912,551 | [['G04.146.954.035'], ['D23.101.140'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['G04.161.750', 'G07.345.249.410.750'], ['C04.557.465.220'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.200.500.386.350', 'E05.242.... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Finger dermatoglyphics in the Corsican population (France). | Finger pattern types, pattern intensity indices and finger ridge counts in 110 individuals (54 males and 56 females) from Corte in the central area of Corsica (France) were investigated. The comparison of the Corsican qualitative and quantitative digital dermatoglyphics with those from other samples of Mediterranean an... | ['Adult', 'Dermatoglyphics', 'Ethnic Groups', 'Female', 'France', 'Gene Frequency', 'Genetics, Population', 'Humans', 'Male'] | 10,676,570 | [['M01.060.116'], ['E05.318.740.225.500.375', 'I01.198.780.937.343', 'N04.452.910.099.500'], ['M01.686.754', 'N01.224.317'], ['Z01.542.286'], ['G05.330'], ['H01.158.273.343.335'], ['B01.050.150.900.649.313.988.400.112.400.400']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Finding locations in the environment: the map as mediator. | When an observer (O) uses a map (M) whose orientation does not correspond to the orientation of the environment (E) in which performance occurs, substantial errors occur: these are called map alignment effects. Much of the prior research on map/environment (M/E) alignment has involved maps of simple paths, although ali... | ['Adult', 'Attention', 'Female', 'Humans', 'Locomotion', 'Male', 'Mental Recall', 'Orientation', 'Social Environment'] | 1,488,270 | [['M01.060.116'], ['F02.830.104.214'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G07.568.500', 'G11.427.410.568'], ['F02.463.425.540.641'], ['F01.058.577', 'F02.830.606'], ['I01.880.853.500']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Faecal lactoferrin assay as an adjunct to Clostridium difficile diarrhoea. | Inflammation is the hallmark of Clostridium difficile associated diarrhoea and lactoferrin is produced by inflammatory cells. The aim of this study was to find out whether faecal lactoferrin latex agglutination (FLLA) assay done simultaneously with Clostridium difficile toxin (CDT) assay would help in the diagnosis of ... | ['Bacterial Toxins', 'Child', 'Child, Preschool', 'Clostridioides difficile', 'Diarrhea', 'Enterocolitis, Pseudomembranous', 'Enterotoxins', 'Feces', 'Female', 'Humans', 'Infant', 'Lactoferrin', 'Latex Fixation Tests', 'Male'] | 12,593,568 | [['D23.946.123'], ['M01.060.406'], ['M01.060.406.448'], ['B03.353.625.657.500'], ['C23.888.821.214'], ['C01.150.252.410.222.310', 'C06.405.205.596.800', 'C06.405.469.363.800'], ['D23.946.330'], ['A12.459'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['D08.811.277.656.300.760.471', 'D08.811.277.65... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Tarnished plant bug (Hemiptera: Miridae) thresholds and sampling comparisons for flowering cotton in the midsouthern United States. | The tarnished plant bug, Lygus lineolaris (Palisot de Beauvois) (Hemiptera: Miridae), has become the primary target of foliar insecticides in cotton, Gossypium hirsutum L., throughout the Midsouth over the past several years. This prompted a reevaluation of existing action thresholds for flowering cotton under current ... | ['Animals', 'Cotton Fiber', 'Flowers', 'Geography', 'Gossypium', 'Hemiptera', 'Insecticides', 'Population Density', 'Sample Size', 'Southeastern United States', 'Southwestern United States'] | 19,886,447 | [['B01.050'], ['J01.637.836.299'], ['A18.024.249.500'], ['H01.277.500'], ['B01.650.940.800.575.912.250.859.821.500.244'], ['B01.050.500.131.617.412'], ['D27.720.031.700.491', 'D27.888.723.491'], ['N01.224.600', 'N06.850.505.400.600'], ['E05.318.370.762', 'E05.581.500.902', 'N05.715.360.325.692', 'N06.850.520.445.762'],... | ['Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 |
A pheromone-induced developmental switch in Caenorhabditis elegans: Temperature-sensitive mutants reveal a wild-type temperature-dependent process. | Formation of a developmentally arrested dispersal stage called the dauer larva is enhanced by a Caenorhabditis-specific pheromone and is inhibited by increasing amounts of food. Pheromone-induced dauer larva formation of three tested wild-type strains is temperature-dependent, so that an increased percentage of the pop... | ['Animals', 'Caenorhabditis', 'Female', 'Larva', 'Mutation', 'Oviposition', 'Pheromones', 'Temperature'] | 6,583,682 | [['B01.050'], ['B01.050.500.500.294.400.875.660.250'], ['B05.500.500', 'G07.345.500.550.500.500'], ['G05.365.590'], ['G08.686.784.480'], ['D23.641'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.150.450', 'N06.230.300.100.725.710']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Rapid detection directly from patient serum samples of human cytomegalovirus UL97 mutations conferring ganciclovir resistance. | Ganciclovir-resistant cytomegalovirus can cause disease and death in transplant recipients. We describe here a rapid PCR- and sequencing-based assay for ganciclovir resistance that can be performed in 1 to 2 working days directly from patient specimens, without the need for amplification of the virus by cell culture. A... | ['Antiviral Agents', 'Cytomegalovirus', 'Cytomegalovirus Infections', 'Drug Resistance, Viral', 'Ganciclovir', 'Humans', 'Microbial Sensitivity Tests', 'Mutation, Missense', 'Phosphotransferases (Alcohol Group Acceptor)', 'Polymerase Chain Reaction', 'Sequence Analysis, DNA', 'Serum'] | 17,537,934 | [['D27.505.954.122.388'], ['B04.280.382.150.150'], ['C01.925.256.466.245'], ['G06.225.420', 'G06.920.225', 'G07.690.773.984.269.420'], ['D03.633.100.759.758.399.454.250.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.875.595', 'E05.200.875.595', 'E05.337.550.400'], ['G05.365.590.650'], ['D08.811.9... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Ethnic patterns of Hodgkin's disease incidence among children and adolescents in the United States, 1973-82. | The descriptive epidemiologic findings were summarized on 1,109 patients (white, black, and Hispanic) under 20 years of age who were diagnosed with Hodgkin's disease as reported to the Surveillance, Epidemiology, and End Results ("SEER") Program of the National Cancer Institute from 1973 to 1982. Across all ethnic stra... | ['Adolescent', 'Age Factors', 'California', 'Child', 'Ethnic Groups', 'Female', 'Georgia', 'Hodgkin Disease', 'Humans', 'Iowa', 'Male', 'Michigan', 'Sex Factors', 'Time Factors'] | 3,456,062 | [['M01.060.057'], ['N05.715.350.075', 'N06.850.490.250'], ['Z01.107.567.875.580.200', 'Z01.107.567.875.760.200'], ['M01.060.406'], ['M01.686.754', 'N01.224.317'], ['Z01.107.567.875.075.250', 'Z01.107.567.875.750.370'], ['C04.557.386.355', 'C15.604.515.569.355', 'C20.683.515.761.355'], ['B01.050.150.900.649.313.988.400.... | ['Named Groups [M]', 'Health Care [N]', 'Geographicals [Z]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Antitumor mechanisms of Eubacterium lentum and its components. | In the present study, some antitumor mechanisms of Eubacterium lentum (TYH-11) and bacterial components having antitumor effects were investigated. E.lentum induced maximum NK cell activity in C3H/He mice on day 1 after injection (90.6% against 33.9% of control at E:T ratio 50:1) and the activity was kept at a level of... | ['Adjuvants, Immunologic', 'Animals', 'Antineoplastic Agents', 'Cytotoxicity, Immunologic', 'Eubacterium', 'Killer Cells, Natural', 'Macrophages, Peritoneal', 'Male', 'Mice', 'Serial Passage', 'Tumor Cells, Cultured'] | 8,703,241 | [['D27.505.696.477.067'], ['B01.050'], ['D27.505.954.248'], ['G12.287'], ['B03.353.625.750', 'B03.510.460.400.400.250'], ['A11.118.637.555.567.537', 'A15.145.229.637.555.567.537', 'A15.382.490.555.567.537'], ['A11.329.372.630', 'A11.627.482.630', 'A11.733.397.630', 'A15.382.670.522.630', 'A15.382.680.397.630'], ['B01.0... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Evidence for a dopaminergic innervation of the subthalamic nucleus in the rat. | The dopaminergic connection from the substantia nigra pars compacta (SNc) and the ventral tegmental area (VTA) to the subthalamic nucleus in the rat was investigated using anterograde and retrograde tracers. Iontophoretic injection of the retrograde tracer fluoro-gold (FG) into the subthalamic nucleus resulted in a sub... | ['Animals', 'Axons', 'Dopamine', 'Fluorescent Dyes', 'Immunohistochemistry', 'Lysine', 'Male', 'Neural Pathways', 'Rats', 'Rats, Wistar', 'Stilbamidines', 'Substantia Nigra', 'Thalamic Nuclei', 'Tyrosine 3-Monooxygenase'] | 9,070,631 | [['B01.050'], ['A08.675.542.145', 'A11.284.180.075', 'A11.671.137', 'A11.671.501.145'], ['D02.092.211.215.406', 'D02.092.311.342', 'D02.455.426.559.389.657.166.175.342'], ['D27.720.233.348', 'D27.720.470.410.505.500'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', ... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Sexual and Reproductive Health Education Needs, Gender Roles Attitudes and Acceptance of Couple Violence According to Engaged Men and Women. | This descriptive study was aimed to evaluate the attitudes of the engaged men and women who are of legal age to marry towards gender roles and acceptance of couple violence, and determine their sexual/reproductive health education needs. It was conducted in two marriage registry offices in Ankara, Turkey. The study sam... | ['Adult', 'Female', 'Gender Identity', 'Health Education', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Intimate Partner Violence', 'Male', 'Marital Status', 'Marriage', 'Needs Assessment', 'Registries', 'Reproductive Health', 'Sex Education', 'Sexual Health', 'Sexual Partners', 'Surveys and Questionnaires', 'Tu... | 29,335,810 | [['M01.060.116'], ['F01.393.446.250', 'F01.752.747.385.200', 'F01.752.747.722.200', 'F02.739.794.793.200'], ['I02.233.332', 'N02.421.726.407'], ['F01.100.150.500', 'N05.300.150.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I01.198.240.856.575', 'I01.880.735.900.688'], ['F01.829.263.315.500', 'I01.240.361.50... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
ThermoData Engine (TDE): software implementation of the dynamic data evaluation concept. 5. Experiment planning and product design. | ThermoData Engine (TDE) is the first full-scale software implementation of the dynamic data evaluation concept, as reported recently in this journal. In the present paper, we describe development of an algorithmic approach to assist experiment planning through assessment of the existing body of knowledge, including ava... | ['Algorithms', 'Drug Design', 'Physical Phenomena', 'Reproducibility of Results', 'Research Design', 'Software', 'Temperature', 'Volatilization'] | 21,166,466 | [['G17.035', 'L01.224.050'], ['E05.290.500', 'H01.158.703.007.338.500', 'H01.181.466.338.500'], ['G01'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['E05.581.500', 'H01.770.644.728'], ['L01.224.900'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.150.4... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Molecular characterization of the "26S" proteasome complex from rat liver. | The molecular properties of an ATP/ubiquitin-dependent "26S" proteasome complex purified from rat liver were examined by physicochemical, biochemical, and morphological analyses. On ultracentrifugation, the proteasome complex sedimented as almost a single component with a sedimentation coefficient of 30.3S. Dynamic lig... | ['Adenosine Triphosphate', 'Amino Acid Sequence', 'Animals', 'Centrifugation, Density Gradient', 'Chemical Phenomena', 'Chemistry, Physical', 'Cysteine Endopeptidases', 'Light', 'Liver', 'Microscopy, Electron', 'Models, Molecular', 'Molecular Sequence Data', 'Molecular Weight', 'Multienzyme Complexes', 'Proteasome Endo... | 8,003,381 | [['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['E05.181.724.336', 'E05.196.941.336'], ['G02'], ['H01.181.529'], ['D08.811.277.656.262.500', 'D08.811.277.656.300.200'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G0... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
FPV: fast protein visualization using Java 3D. | MOTIVATION: Many tools have been developed to visualize protein structures. Tools that have been based on Java 3D((TM)) are compatible among different systems and they can be run remotely through web browsers. However, using Java 3D for visualization has some performance issues with it. The primary concerns about molec... | ['Computer Graphics', 'Computer Simulation', 'Computing Methodologies', 'Database Management Systems', 'Databases, Protein', 'Hypermedia', 'Imaging, Three-Dimensional', 'Information Storage and Retrieval', 'Internet', 'Models, Molecular', 'Programming Languages', 'Protein Conformation', 'Proteins', 'Quality Control', '... | 12,761,052 | [['L01.224.108', 'L01.296.110'], ['L01.224.160'], ['L01.224'], ['L01.224.068', 'L01.224.900.280', 'N04.452.515.110'], ['L01.313.500.750.300.188.400.300.750', 'L01.313.500.750.300.188.400.325.710', 'L01.470.750.750.300.750', 'L01.470.750.750.325.710'], ['L01.224.900.590'], ['E01.370.350.400', 'L01.224.308.410'], ['L01.3... | ['Information Science [L]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 |
A century of medical students' activities (Medical College Union/Medical Society). | The Medical College Union (MCU) was formed in 1922 to encourage and promote comradeship and public spirit amongst the students of King Edward VII College of Medicine. The Medical College Union Society was founded and held its first meeting on 31 July 1936. However, the Annual Report for 1940-42 made no reference to the... | ['History, 20th Century', 'Humans', 'Schools, Medical', 'Self-Help Groups', 'Singapore', 'Societies, Medical', 'Students, Medical'] | 16,010,398 | [['K01.400.504.968'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I02.783.495.552', 'N02.278.020.578'], ['N03.540.782'], ['Z01.252.145.774'], ['N03.540.828.589'], ['M01.848.769.602']] | ['Humanities [K]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Geographicals [Z]', 'Named Groups [M]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
[Optimization of the spiral drill for use in medicine]. | Cutting tools are used in medicine a long time ago. Varying mechanical and thermal damage to bone tissue results from using cutting tools. These are often commented in the literature, but there is hardly any systematic studies of optimization of cutting tools. This present study was initiated in an attempt to improve t... | ['Animals', 'Bone and Bones', 'Burns', 'Cattle', 'Hot Temperature', 'Intraoperative Complications', 'Mathematics', 'Surgical Instruments'] | 3,673,178 | [['B01.050'], ['A02.835.232', 'A10.165.265'], ['C26.200'], ['B01.050.150.900.649.313.500.380.271'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.775.710.380', 'N06.230.300.100.725.232', 'N06.230.300.100.725.710.380'], ['C23.550.505'], ['H01.548'], ['E07.858.700']] | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Base-compositional biases and the bat problem. II. DNA-hybridization trees based on AT- and GC-enriched tracers. | We conducted a series of parallel DNA-hybridization experiments on a small group of bats (species of Pteropus, Rhinolophus, Noctilio and Pteronotus) and outgroups (Lemur, Cynocephalus, Didelphis), using whole-genome labels and tracers made from extracts enriched with AT and two levels of GC content. FITCH (additive phy... | ['Animals', 'Base Composition', 'Chiroptera', 'In Situ Hybridization', 'Least-Squares Analysis', 'Models, Biological', 'Phylogeny'] | 9,569,431 | [['B01.050'], ['G02.111.080'], ['B01.050.150.900.649.313.937'], ['E01.370.225.500.620.670.325', 'E01.370.225.750.600.670.325', 'E05.200.500.620.670.325', 'E05.200.750.600.670.325', 'E05.393.661.475'], ['E05.318.740.750.400', 'N05.715.360.750.695.440', 'N06.850.520.830.750.400'], ['E05.599.395'], ['G05.697', 'G16.075.60... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Structural and biochemical characterization of 20â-hydroxysteroid dehydrogenase from Bifidobacterium adolescentis | Anaerobic bacteria inhabiting the human gastrointestinal tract have evolved various enzymes that modify host-derived steroids. The bacterial steroid-17,20-desmolase pathway cleaves the cortisol side chain, forming pro-androgens predicted to impact host physiology. Bacterial 20â-hydroxysteroid dehydrogenase (20â-HSDH) r... | ['Bacterial Proteins', 'Bifidobacterium adolescentis', 'Crystallography, X-Ray', 'Hydrocortisone', 'Hydroxysteroid Dehydrogenases', 'Kinetics', 'Mutagenesis, Site-Directed', 'NAD', 'Protein Binding', 'Protein Structure, Secondary', 'Protein Structure, Tertiary', 'Recombinant Proteins', 'Substrate Specificity'] | 31,209,107 | [['D12.776.097'], ['B03.510.024.100.125', 'B03.510.460.400.400.049.100.125'], ['E05.196.309.742.225'], ['D04.210.500.745.745.654.600', 'D06.472.040.585.353.476', 'D06.472.040.585.478.392'], ['D08.811.682.047.436'], ['G01.374.661', 'G02.111.490'], ['E05.393.420.601.575'], ['D03.633.100.759.646.138.694', 'D08.211.589', '... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The cell wall of Arabidopsis thaliana influences actin network dynamics. | In plant cells, molecular connections link the cell wall-plasma membrane-actin cytoskeleton to form a continuum. It is hypothesized that the cell wall provides stable anchor points around which the actin cytoskeleton remodels. Here we use live cell imaging of fluorescently labelled marker proteins to quantify the organ... | ['Actin Cytoskeleton', 'Arabidopsis', 'Benzamides', 'Cell Membrane', 'Cell Wall', 'Golgi Apparatus', 'Green Fluorescent Proteins', 'Plants, Genetically Modified'] | 28,981,774 | [['A11.284.430.214.190.750.050'], ['B01.650.940.800.575.912.250.157.100'], ['D02.065.277', 'D02.241.223.100.100', 'D02.455.426.559.389.127.085'], ['A11.284.149'], ['A11.284.183'], ['A11.284.430.214.190.875.336'], ['D12.776.532.265'], ['B01.650.520', 'B05.620.600']] | ['Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Long non-coding RNA ZFAS1 promotes nasopharyngeal carcinoma through activation of Wnt/â-catenin pathway. | OBJECTIVE: To investigate the expression characteristics of long non-coding RNA (lncRNA) ZFAS1 in nasopharyngeal carcinoma (NPC) and to further investigate the role and mechanism of ZFAS1 in the occurrence and development of NPC.PATIENTS AND METHODS: 76 surgical excision samples from newly diagnosed NPC patients and 76... | ['Apoptosis', 'Biomarkers, Tumor', 'Cell Cycle', 'Cell Line, Tumor', 'Cell Proliferation', 'Gene Expression Regulation, Neoplastic', 'Gene Knockdown Techniques', 'Humans', 'Lymphatic Metastasis', 'Nasopharyngeal Carcinoma', 'Nasopharyngeal Neoplasms', 'Prognosis', 'RNA, Long Noncoding', 'RNA, Small Interfering', 'Survi... | 29,917,194 | [['G04.146.954.035'], ['D23.101.140'], ['G04.144'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.161.750', 'G07.345.249.410.750'], ['G05.308.370'], ['E05.393.335.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.697.650.560', 'C23.550.727.650.560'], ['C04.557.470.200.623', 'C04.588.443.665.710.650.500', 'C... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Non-enzymatic protein glycosylation: back-titration assay. | The glycosylation of albumin in vitro, as judged from the incorporation of D-[U-14C]glucose into trichloroacetic acid (TCA)-precipitable material represents a time-, temperature- and concentration-related process. It is markedly increased by NaCNBH3. A close correlation is observed between the radioactive data and the ... | ['Animals', 'Carbon Radioisotopes', 'Diabetes Mellitus', 'Fructose', 'Galactose', 'Glucose', 'Glycosylation', 'Hexosephosphates', 'Humans', 'Kinetics', 'Mannose', 'Radioisotope Dilution Technique', 'Rats', 'Reference Values', 'Serum Albumin', 'Serum Albumin, Bovine'] | 2,404,727 | [['B01.050'], ['D01.268.150.075.328', 'D01.496.123.328', 'D01.496.749.154'], ['C18.452.394.750', 'C19.246'], ['D09.947.875.359.250', 'D09.947.875.465.354'], ['D09.947.875.359.377'], ['D09.947.875.359.448'], ['G02.111.158.812', 'G02.607.299', 'G03.191.812'], ['D09.894.417'], ['B01.050.150.900.649.313.988.400.112.400.400... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Polypeptide toxins from the venoms of Old World and New World scorpions preferentially block different potassium channels. | Venoms from five Old World and two New World scorpions were tested for their ability to block various K+ channels in rat brain synaptosomes. A 86Rb efflux kinetic assay was used to identify three types of K+ channels, Ca(2+)-independent, voltage-gated, inactivating (A-type) and noninactivating (delayed rectifier) K+ ch... | ['Animals', 'Brain', 'Calcium', 'Drug Synergism', 'Peptides', 'Potassium Channels', 'Rats', 'Rubidium', 'Rubidium Radioisotopes', 'Scorpion Venoms', 'Structure-Activity Relationship', 'Synaptosomes', 'Toxins, Biological'] | 1,758,443 | [['B01.050'], ['A08.186.211'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['G07.690.773.968.477'], ['D12.644'], ['D12.776.157.530.400.600', 'D12.776.543.550.450.750', 'D12.776.543.585.400.750'], ['B01.050.150.900.649.313.992.635.505.700'], ['D01.268.549.650', 'D01.268.556.800', 'D01.552.528.759', 'D01.552.5... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Anterior transvertebral transposition of the spinal cord for the relief of paraplegia associated with congenital cervicothoracic kyphoscoliosis. Technical note. | The authors describe a technique for the relief of spinal cord compression associated with congenital kyphoscoliosis. A 13-year-old girl with congenital cervicothoracic kyphoscoliosis had undergone in situ fusion; spastic paraparesis and bladder disturbance developed postoperatively. Spinal cord detethering and postero... | ['Adolescent', 'Female', 'Humans', 'Kyphosis', 'Lumbar Vertebrae', 'Neurosurgical Procedures', 'Paraplegia', 'Scoliosis', 'Spinal Cord Compression'] | 17,048,777 | [['M01.060.057'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C05.116.900.800.500'], ['A02.835.232.834.519'], ['E04.525'], ['C10.597.622.669', 'C23.888.592.636.637'], ['C05.116.900.800.875'], ['C10.228.854.761', 'C26.819.678']] | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Computational Methods for Human Microbiome Analysis. | As the field of microbiomics advances, the burden of computational work that scientists need to perform in order to extract biological insight has grown accordingly. Likewise, while human microbiome analyses are increasingly shifting toward a greater integration of various high-throughput data types, a core number of m... | ['Computational Biology', 'Humans', 'Metagenomics', 'Microbiota'] | 29,120,486 | [['H01.158.273.180', 'L01.313.124'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H01.158.273.343.350.261'], ['G06.591', 'G16.500.275.157.049.100.500', 'N06.230.124.049.100.500']] | ['Disciplines and Occupations [H]', 'Information Science [L]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
'Learning to live with OCD is a little mantra I often repeat': understanding the lived experience of obsessive-compulsive disorder (OCD) in the contemporary therapeutic context. | OBJECTIVES: While there has been an abundance of quantitative studies that examine the clinical features and treatment modalities of obsessive-compulsive disorder (OCD), only a few qualitative research studies examining the experience of OCD have been documented. Our objectives were to explore and understand psychosoci... | ['Adaptation, Psychological', 'Adult', 'Attitude to Health', 'Cognitive Behavioral Therapy', 'Female', 'Goals', 'Humans', 'Male', 'Middle Aged', 'Obsessive-Compulsive Disorder', 'Professional-Patient Relations', 'Qualitative Research', 'Self Concept', 'Social Participation', 'Social Stigma', 'Treatment Outcome', 'Young... | 24,497,400 | [['F01.058'], ['M01.060.116'], ['F01.100.150', 'N05.300.150'], ['F04.754.137.350'], ['F01.658.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['F03.080.600'], ['F01.829.401.650', 'N05.300.660'], ['H01.770.644.241.850'], ['F01.752.747.792'], ['I03.050.750'], ['F01.145.813.840'], ['E01.789.80... | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 |
Neurodevelopmental Outcomes and Neural Mechanisms Associated with Non-right Handedness in Children Born Very Preterm. | Non-right handedness (NRH) is reportedly more common in very preterm (VPT; <32 weeks' gestation) children compared with term-born peers, but it is unclear whether neonatal brain injury or altered brain morphology and microstructure underpins NRH in this population. Given that NRH has been inconsistently reported to be ... | ['Anisotropy', 'Brain Injuries', 'Child', 'Developmental Disabilities', 'Female', 'Follow-Up Studies', 'Functional Laterality', 'Gestational Age', 'Humans', 'Imaging, Three-Dimensional', 'Magnetic Resonance Imaging', 'Male', 'Neuropsychological Tests', 'Premature Birth', 'Psychiatric Status Rating Scales'] | 26,328,609 | [['G01.590.040', 'G02.050'], ['C10.228.140.199', 'C10.900.300.087', 'C26.915.300.200'], ['M01.060.406'], ['F03.625.421'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['F02.830.297.425', 'G11.561.225.425'], ['G07.345.500.325.235.968', 'G08.686.320'], ['B01.050.150.900.649.3... | ['Phenomena and Processes [G]', 'Diseases [C]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Information Science [L]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Lateral thalamic control of nociceptive response after whisker pad injection of varicella zoster virus. | Pain is a common complication of herpes zoster (HZ) infection which results from reactivation of a latent varicella zoster virus (VZV). A third of HZ patients' progress to a chronic pain state known as post herpetic neuralgia (PHN), and about a quarter of these patients' have orofacial pain. The mechanisms controlling ... | ['Animals', 'Disease Models, Animal', 'Herpes Zoster', 'Herpesvirus 3, Human', 'Injections', 'Male', 'Neuralgia', 'Neuralgia, Postherpetic', 'Rats, Sprague-Dawley'] | 28,549,561 | [['B01.050'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['C01.925.256.466.930.750'], ['B04.280.382.100.900.460'], ['E02.319.267.530'], ['C10.668.829.600', 'C23.888.592.612.664'], ['C10.668.829.600.550', 'C23.888.592.612.664.550'], ['B01.050.150.900.649.313.992.635.505.700.750']] | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Pigmentary retinal dystrophy associated with pigmentary glaucoma. | Two young brothers were bilaterally affected by pigmentary glaucoma and extensive symmetrical changes of the retinal pigment epithelium (RPE). Fundus changes consisted in widespread salt-and-pepper RPE mottling and pigment clumping, sparing only the peripapillary and foveal areas. During the course of 4 years, one of t... | ['Adult', 'Fundus Oculi', 'Glaucoma, Open-Angle', 'Humans', 'Intraocular Pressure', 'Laser Therapy', 'Male', 'Neovascularization, Pathologic', 'Pigment Epithelium of Eye', 'Retina', 'Retinal Degeneration', 'Retinal Detachment', 'Visual Acuity', 'Visual Field Tests'] | 2,476,365 | [['M01.060.116'], ['A09.371.729.313'], ['C11.525.381.407'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G14.440'], ['E02.594', 'E04.014.520'], ['C23.550.589.500'], ['A09.371.670', 'A10.272.640'], ['A09.371.729'], ['C11.270.612', 'C11.768.585'], ['C11.768.648'], ['E01.370.380.850.950', 'F02.463.593.932.901', 'G14... | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Safflower (Catharmus tinctorius L.) oil supplementation in overnourished rats during early neonatal development: effects on heart and liver function in the adult. | Carthamus tinctorius L. (common name: safflower) is an herb whose extracted oil (safflower oil) has been employed in both alternative and conventional medicine in the treatment of disease. Overnutrition during early postnatal life can increase the lifetime risk of obesity and metabolic syndrome. Here we investigate the... | ['Animals', 'Carthamus tinctorius', 'Dietary Supplements', 'Fatty Acids, Omega-6', 'Female', 'Hyperglycemia', 'Hyperlipidemias', 'Lactation', 'Liver', 'Male', 'Maternal Nutritional Physiological Phenomena', 'Myocardium', 'Obesity', 'Overnutrition', 'Oxidative Stress', 'Plant Preparations', 'Pregnancy', 'Random Allocati... | 27,863,203 | [['B01.050'], ['B01.650.940.800.575.912.250.100.181.500'], ['G07.203.300.456', 'J02.500.456'], ['D10.251.355.343'], ['C18.452.394.952'], ['C18.452.584.500.500'], ['G08.686.523', 'G08.686.702.500'], ['A03.620'], ['G07.203.650.566'], ['A02.633.580', 'A07.541.704', 'A10.690.552.750'], ['C18.654.726.500', 'C23.888.144.699.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Quantifying the effects of four weeks of low-volume high-intensity sprint interval training on V?O2max through assessment of hemodynamics. | BACKGROUND: Sprint interval training is a popular workout modality. Studies have eluded to a positive effect on maximal oxygen uptake, however little is known about the mechanistic basis of this adaptation. Therefore, the purpose of this study was to determine the effects of a short-term high-intensity sprint interval ... | ['Adolescent', 'Adult', 'Cardiac Output', 'Cardiorespiratory Fitness', 'Female', 'Heart', 'Hemodynamics', 'High-Intensity Interval Training', 'Humans', 'Male', 'Oxygen', 'Oxygen Consumption'] | 32,008,311 | [['M01.060.057'], ['M01.060.116'], ['E01.370.370.380.150', 'G09.330.380.124'], ['G11.427.685.500', 'I03.450.642.845.054.300', 'I03.450.642.845.054.800.500', 'N01.400.150', 'N01.400.545.500'], ['A07.541'], ['G09.330.380'], ['G11.427.410.698.277.311.250', 'I03.350.311.250'], ['B01.050.150.900.649.313.988.400.112.400.400'... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Cyclization of peptides through a urea bond: application to the Arg-Gly-Asp tripeptide. | Various synthetic cyclopeptides bind different cellular proteins with high affinity and specificity. In this study, we designed a new series of cyclic tetrapeptides containing the RGD sequence, a ligand for the alpha(v)beta(3) integrin receptor, in which the ring closure was performed through a urea bond between the al... | ['Angiogenesis Inhibitors', 'Animals', 'Cell Line', 'Cell Line, Tumor', 'Cyclization', 'Humans', 'Integrin alphaVbeta3', 'Lung Neoplasms', 'Melanoma', 'Mice', 'Mice, Inbred C57BL', 'Oligopeptides', 'Urea'] | 20,422,669 | [['D27.505.696.377.077.099', 'D27.505.696.377.450.100', 'D27.505.954.248.025'], ['B01.050'], ['A11.251.210'], ['A11.251.210.190', 'A11.251.860.180'], ['G02.111.180', 'G02.607.133', 'G03.208'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.395.550.625.439', 'D12.776.543.550.625.439', 'D12.776.543.750.705.40... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Simultaneous determination of 14 nutrients in vegetable oils by ultra high performance liquid chromatography-tandem mass spectrometry]. | A method for the simultaneous determination of four tocopherols, four tocotrienols, four phytosterols, â-carotene and squalene by ultra high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) was developed. After saponification, the samples were extracted with petroleum ether, and the extract solu... | ['Chromatography, High Pressure Liquid', 'Limit of Detection', 'Plant Oils', 'Tandem Mass Spectrometry', 'Vegetables'] | 30,378,377 | [['E05.196.181.400.300'], ['E05.318.740.872.374', 'N05.715.360.750.725.500', 'N06.850.520.830.872.500'], ['D10.627.700', 'D20.215.784.750'], ['E05.196.566.880'], ['B01.650.160.956', 'B01.650.510.956', 'G07.203.300.850', 'J02.500.850']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Altered serum levels of kynurenine metabolites in patients affected by cluster headache. | BACKGROUND: The reported efficacy of memantine in the treatment of patients with cluster headache (CH) suggests that NMDA receptors are involved in mechanisms of nociceptive sensitization within the trigeminal system associated with CH. NMDA receptors are activated or inhibited by neuroactive compounds generated by try... | ['Adult', 'Cluster Headache', 'Female', 'Humans', 'Hydroxyindoleacetic Acid', 'Kynurenic Acid', 'Kynurenine', 'Male', 'Middle Aged', 'Quinolinic Acid', 'Tryptophan', 'Xanthurenates', 'ortho-Aminobenzoates'] | 27,000,870 | [['M01.060.116'], ['C10.228.140.546.399.937.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.066.288.478', 'D03.633.100.473.404.478'], ['D03.066.942.505', 'D03.633.100.810.350.400'], ['D12.125.608'], ['M01.060.116.630'], ['D03.383.725.822.700'], ['D12.125.072.050.850', 'D12.125.142.875'], ['D03.066.942'], ... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Molecular typing and characterization of a novel genotype of EV-B93 isolated from Tibet, China. | EV-B93 is a novel serotype within the Enterovirus B species and is uncommon worldwide. Currently, only one full-length genomic sequence (the prototype strain) has been deposited in the GenBank database. In this study, three EV-B93 were identified, including one from an acute flaccid paralysis (AFP) patient (named 99052... | ['Child, Preschool', 'Disease Outbreaks', 'Enterovirus B, Human', 'Enterovirus Infections', 'Feces', 'Female', 'Genome, Viral', 'Humans', 'Infant', 'Male', 'Molecular Typing', 'Paralysis', 'Phylogeny', 'RNA, Viral', 'Recombination, Genetic', 'Sequence Analysis, RNA', 'Seroepidemiologic Studies', 'Tibet'] | 32,841,272 | [['M01.060.406.448'], ['N06.850.290'], ['B04.820.578.750.284.182'], ['C01.925.782.687.359'], ['A12.459'], ['G05.360.340.358.840'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['E01.370.225.875.150.125.457', 'E05.200.875.150.125.457', 'E05.393.542'], ['C10.597.622', 'C23.888.592.636'], ['G05.697', ... | ['Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Geographicals [Z]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
Learning needs analysis--developing a new tool for general practice training. | BACKGROUND: General practice registrars are a diverse group of doctors, each with a unique set of learning needs. This diversity sets training providers the challenge of identifying the learning needs of individual registrars early and then tailoring their educational programs to meet those needs.OBJECTIVE: This articl... | ['Australia', 'Clinical Competence', 'Family Practice', 'Humans'] | 16,369,682 | [['Z01.639.100', 'Z01.678.100.373'], ['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['H02.403.340.500'], ['B01.050.150.900.649.313.988.400.112.400.400']] | ['Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 |
The CCK-2/gastrin splice variant receptor retaining intron 4 transactivates the COX-2 promoter in vitro. | The expression of the human cholecystokinin-2/gastrin receptor (CCK-2R) has been widely reported in human colorectal cancers. Recently, a splice variant of the CCK-2R retaining intron 4 (CCK-2i4svR) has been cloned from human colorectal cancers and postulated to exhibit constitutive activity. But its role in mediating ... | ['Animals', 'COS Cells', 'Chlorocebus aethiops', 'Colonic Neoplasms', 'Cyclooxygenase 2', 'Dinoprostone', 'Enzyme-Linked Immunosorbent Assay', 'Gastrins', 'Genes, Reporter', 'Humans', 'Introns', 'Luciferases', 'Plasmids', 'Promoter Regions, Genetic', 'Protein Isoforms', 'RNA, Messenger', 'Receptor, Cholecystokinin B', ... | 17,936,921 | [['B01.050'], ['A11.251.210.172.500', 'A11.329.228.220'], ['B01.050.150.900.649.313.988.400.112.199.120.126.110'], ['C04.588.274.476.411.307.180', 'C06.301.371.411.307.180', 'C06.405.249.411.307.180', 'C06.405.469.158.356.180', 'C06.405.469.491.307.180'], ['D08.811.600.720.750'], ['D10.251.355.255.550.250.200', 'D23.46... | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Depersonalization, social phobia and shame]. | Associations between depersonalization (DP) and social phobia (SP) were described in the early scientific literature. This connection, however, has not yet been considered in the recent empirical literature and clinical trials on SP. The aim of this study is to examine these associations. In a sample of 100 consecutive... | ['Depersonalization', 'Humans', 'Phobic Disorders', 'Psychiatric Status Rating Scales', 'Psychological Tests', 'Shame'] | 17,031,770 | [['F01.145.126.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F03.080.725'], ['F04.711.513.653'], ['F04.711'], ['F01.470.483.666']] | ['Psychiatry and Psychology [F]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Studies of airway inflammation in asthma and chronic airflow limitation. Do they help to explain causes? | Although progress seems slow, it is urgent to find ways to prevent asthma in children and CAL in smokers. Understanding the mechanisms of disease is usually important to preventing them. In airway disease there remain many opportunities to make progress in understanding causes by studying the nature of the pathological... | ['Asthma', 'Bronchitis', 'Humans', 'Immunohistochemistry', 'Lung Diseases, Obstructive', 'Smoking'] | 7,952,582 | [['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['C01.748.099', 'C08.127.446', 'C08.381.495.146', 'C08.730.099'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.6... | ['Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Polarity-dependent effects of transcranial direct current stimulation in obsessive-compulsive disorder. | About one third of patients with obsessive-compulsive disorder (OCD) fail to experience significant clinical benefit from currently available treatments. Hyperactivity of the presupplementary motor area (pre-SMA) has been detected in OCD patients, but it is not clear whether it is the primary cause or a secondary compe... | ['Adult', 'Female', 'Humans', 'Motor Cortex', 'Obsessive-Compulsive Disorder', 'Severity of Illness Index', 'Transcranial Direct Current Stimulation', 'Treatment Outcome'] | 25,971,992 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A08.186.211.200.885.287.500.270.548', 'A08.186.211.200.885.287.500.814.624'], ['F03.080.600'], ['E05.318.308.980.438.475.456.500', 'N05.715.360.300.800.438.375.364.500', 'N06.850.520.308.980.438.475.364.500'], ['E02.331.750', 'F04.570.200.791', 'F04.6... | ['Named Groups [M]', 'Organisms [B]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Preoperative hip to ankle radiographs in total knee arthroplasty. | Whether a preoperative long leg radiograph taken with the patient standing helps the surgeon reproduce a normal mechanical axis after total knee arthroplasty is unknown. The purpose of the current study was to evaluate whether a preoperative long leg radiograph helps to restore normal limb alignment after total knee ar... | ['Adult', 'Aged', 'Aged, 80 and over', 'Ankle Joint', 'Arthroplasty, Replacement, Knee', 'Hip Joint', 'Humans', 'Knee Joint', 'Leg Bones', 'Middle Aged', 'Preoperative Care', 'Radiography'] | 12,439,260 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['A02.835.583.378.062'], ['E04.555.110.110.115', 'E04.650.110.115', 'E04.680.101.110.115'], ['A02.835.583.411'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.583.475'], ['A02.835.232.043.650'], ['M01.060.116.630'], ['E02.760.795', 'E04.604.75... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A comparative study of the unfolding of the endoglucanase Cel45 from Humicola insolens in denaturant and surfactant. | Cellulases are increasingly being used for industrial purposes, particularly in washing powders, yet little is known of the factors governing the stability of proteins in detergent solutions. We present a comparative analysis of the behavior of the cellulase Cel45 from Humicola insolens in the presence of the denaturan... | ['Acid-Base Equilibrium', 'Alkanesulfonic Acids', 'Cellulase', 'Guanidine', 'Kinetics', 'Mitosporic Fungi', 'Models, Chemical', 'Protein Denaturation', 'Protein Engineering', 'Protein Folding', 'Surface-Active Agents'] | 10,493,589 | [['G02.111.007', 'G02.300.176', 'G03.030', 'G07.410.110', 'G09.188.050'], ['D02.455.326.146.100', 'D02.886.645.600.055'], ['D08.811.277.450.420.200.200'], ['D02.078.370.472'], ['G01.374.661', 'G02.111.490'], ['B01.300.381'], ['E05.599.495'], ['G01.154.651.750.500', 'G02.111.688.750.500'], ['E05.393.420.601'], ['G01.154... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Identification of an epitope of type 1 streptococcal M protein that is shared with a 43-kDa protein of human myocardium and renal glomeruli. | The localization of opsonic and tissue-cross-reactive epitopes within the amino terminus of type 1 streptococcal M protein was investigated by using murine mAb raised against synthetic peptides of type 1 M protein. Two mAb (IIIA2 and IIIB8) reacted with epitopes located within amino acid residues 1-12 of type 1 M prote... | ['Amino Acid Sequence', 'Antibodies, Monoclonal', 'Antigens, Bacterial', 'Bacterial Outer Membrane Proteins', 'Bacterial Proteins', 'Blotting, Western', 'Carrier Proteins', 'Cross Reactions', 'Epitopes', 'Fluorescent Antibody Technique', 'Glomerular Mesangium', 'Humans', 'Kidney Glomerulus', 'Molecular Sequence Data', ... | 1,701,783 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D23.050.161'], ['D12.776.097.120', 'D12.776.543.100'], ['D12.776.097'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['D12... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
On the presynaptic acetylcholine receptors in sympathetic ganglia of the frog. | 1. Action potentials have been recorded extracellularly from individual preganglionic nerve terminals in the lumbar sympathetic chain of frogs (cf. Koketsu & Nishi, 1968).2. The action potentials were unaffected by changes in external Mg(2+) or Ca(2+) concentration, but were attenuated or even abolished by acetylcholin... | ['Acetylcholine', 'Action Potentials', 'Animals', 'Anura', 'Calcium', 'Carbachol', 'Ganglia, Autonomic', 'Magnesium', 'Potassium', 'Receptors, Drug', 'Receptors, Neurotransmitter', 'Synapses', 'Synaptic Transmission', 'Tubocurarine'] | 4,326,849 | [['D02.092.211.111'], ['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['B01.050'], ['B01.050.150.900.090.180'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D02.092.877.883.333.115', 'D02.675.276.232.115'], ['A08.340.315', 'A08.800.050.300'], ['D01.268.552.437', 'D01.268.557.500', 'D01.552.547.500'],... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Specific effects of eccentric training on muscular fatigability. | This study was designed to test the hypothesis that an eccentric training period induces a reduction of neuromuscular fatigability following an eccentric exercise. Before (Pre-T) and after (Post-T) a 7-wks sub-maximal eccentric training, ten active males performed a fatiguing exercise consisting of five sets of ten max... | ['Adaptation, Physiological', 'Adult', 'Humans', 'Male', 'Muscle Contraction', 'Muscle Fatigue', 'Muscle, Skeletal', 'Physical Education and Training', 'Torque'] | 15,162,247 | [['G07.025', 'G16.012.500'], ['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G11.427.494'], ['G11.427.550'], ['A02.633.567', 'A10.690.552.500'], ['I02.233.543'], ['G01.374.860.500']] | ['Phenomena and Processes [G]', 'Named Groups [M]', 'Organisms [B]', 'Anatomy [A]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Purification of protease nexin II from human fibroblasts. | Normal human fibroblasts secrete a protein named protease nexin II (PN II) which previously was shown to form sodium dodecyl sulfate (SDS)-stable complexes with epidermal growth factor-binding protein (EGF-BP). These complexes then bind to the same cells and are rapidly internalized and degraded (Knauer, D.J., and Cunn... | ['Amino Acid Sequence', 'Amyloid beta-Protein Precursor', 'Carrier Proteins', 'Chromatography, Affinity', 'Chromatography, Gel', 'Chromatography, Ion Exchange', 'Fibroblasts', 'Humans', 'Infant, Newborn', 'Male', 'Molecular Weight', 'Protease Nexins', 'Receptors, Cell Surface', 'Skin'] | 3,597,385 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D12.776.049.407.249', 'D12.776.543.039', 'D12.776.645.468.500', 'D12.776.811.050'], ['D12.776.157'], ['E05.196.181.400.170'], ['E05.196.181.400.250'], ['E05.196.181.400.383'], ['A11.329.228'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['G02.494'... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Named Groups [M]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Estrogens maintain bile duct mass and reduce apoptosis after biliodigestive anastomosis in bile duct ligated rats. | BACKGROUND/AIMS: Disapperacence of bile ducts (ductopenia) represents the terminal, common stage of human cholangiopathies, and estrogens exert a major role in stimulating cholangiocyte proliferation. We thus evaluated whether estrogen administration protect from the bile duct loss induced by the biliary-digestive dive... | ['Animals', 'Apoptosis', 'Bile Duct Diseases', 'Bile Ducts', 'Body Weight', 'Cell Proliferation', 'Estradiol', 'Estrogens', 'Liver', 'Male', 'Mitogen-Activated Protein Kinase 1', 'Mitogen-Activated Protein Kinase 3', 'Organ Size', 'Phosphorylation', 'Proliferating Cell Nuclear Antigen', 'Rats', 'Rats, Wistar'] | 16,481,066 | [['B01.050'], ['G04.146.954.035'], ['C06.130.120'], ['A03.159.183'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['G04.161.750', 'G07.345.249.410.750'], ['D04.210.500.365.415.248', 'D06.472.334.851.437.500'], ['D27.505.696.399.472.277'], ['A03.620... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Starfish oocyte maturation: evidence for a cyclic AMP-dependent inhibitory pathway. | Oocyte maturation (meiosis reinitiation) in starfish is induced by the natural hormone 1-methyladenine (1-MeAde). Cyclic AMP seems to play a negative role in maturation since 1-MeAde triggers a decrease of the oocyte cAMP concentration and since intracellular microinjections of cAMP delay or inhibit maturation. Cyclic ... | ['Adenine', 'Animals', 'Cyclic AMP', 'Cyclic GMP', 'Female', 'Oocytes', 'Starfish', 'Stereoisomerism', 'Thionucleotides', 'Time Factors'] | 2,540,053 | [['D03.633.100.759.138'], ['B01.050'], ['D03.633.100.759.646.138.395', 'D13.695.462.200', 'D13.695.667.138.395', 'D13.695.827.068.395'], ['D03.633.100.759.646.454.160', 'D13.695.462.275', 'D13.695.667.454.160', 'D13.695.827.426.160'], ['A05.360.490.690.680', 'A11.497.497.600'], ['B01.050.500.408.765'], ['G02.607.445.68... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Associations between weight perceptions, weight control and body fatness in a multiethnic sample of adolescent girls. | OBJECTIVE: The purpose of the present study was to examine the interactions between weight perceptions, weight control behaviours and body fatness in a multiethnic sample of adolescent girls.DESIGN: A cross-sectional study.SETTING: Girls from European (37.7 %), Pacific Island (21.6 %), East Asian (15.8 %), Maori (10.2 ... | ['Adiposity', 'Adolescent', 'Body Image', 'Body Mass Index', 'Body Weight', 'Child', 'Cross-Sectional Studies', 'Diet, Reducing', 'Electric Impedance', 'Ethnic Groups', 'Exercise', 'Female', 'Humans', 'Overweight', 'Perception', 'Psychology, Adolescent', 'Self Concept'] | 20,188,006 | [['E01.370.600.115.100.062.500', 'G02.111.130.134.500', 'G03.180.134.500', 'G07.100.049.134.500'], ['M01.060.057'], ['F01.752.747.792.110', 'F02.463.593.112'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.75... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Oral erythromycin treatment for childhood blepharokeratitis. | Blepharokeratitis is a chronic external ocular and adnexal inflammatory condition marked by erythematous and edematous lid margins, lid margin crusting and scaling, meibomian gland inflammation and inspissation, and conjunctival hyperemia. The associated keratitis usually involves the inferior cornea and is characteriz... | ['Administration, Oral', 'Anti-Bacterial Agents', 'Blepharitis', 'Child', 'Child, Preschool', 'Chronic Disease', 'Erythromycin', 'Eye Infections, Bacterial', 'Female', 'Humans', 'Keratitis', 'Male'] | 11,124,676 | [['E02.319.267.100'], ['D27.505.954.122.085'], ['C11.338.133'], ['M01.060.406'], ['M01.060.406.448'], ['C23.550.291.500'], ['D02.540.576.500.992'], ['C01.150.252.289', 'C01.375.354', 'C11.294.354'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C11.204.564']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Named Groups [M]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Has phlebography become useless in the diagnosis of deep venous thrombosis of the lower extremities?]. | It is now widely accepted that the clinical diagnosis of deep venous thrombosis (D.V.T.) is unreliable. Many venous thrombi are nonobstructive and not associated with vessel wall inflammation or inflammation of the surrounding tissues and consequently have no detectable clinical manifestations. Moreover, none of the sy... | ['Humans', 'Iodine Radioisotopes', 'Phlebography', 'Plethysmography, Impedance', 'Recurrence', 'Thrombophlebitis', 'Ultrasonography', 'Veins'] | 3,295,095 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.268.380.400.500.496', 'D01.496.448.496', 'D01.496.749.474'], ['E01.370.350.700.060.600', 'E01.370.370.050.600'], ['E01.370.370.610.610', 'E01.370.405.610'], ['C23.550.291.937'], ['C14.907.355.830.925.770', 'C14.907.617.718.788', 'C14.907.940.740.910'], ['E01.370.3... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of glucocorticosteroids on primary human skin fibroblasts. II. Effects on total protein and collagen biosynthesis by confluent cell cultures. | Confluent cultures of normal primary human skin fibroblasts were incubated with various glucocorticosteroids which are in current use clinically for the treatment of various skin disorders. For all steroids concentrations were found at which collagen hydroxyproline formation was inhibited, while total protein synthesis... | ['Administration, Topical', 'Adult', 'Anti-Inflammatory Agents', 'Betamethasone Valerate', 'Cell Division', 'Cells, Cultured', 'Clobetasol', 'Collagen', 'Depression, Chemical', 'Fibroblasts', 'Glucocorticoids', 'Humans', 'Hydrocortisone', 'Hydroxyproline', 'Protein Biosynthesis', 'Psoriasis', 'Skin', 'Triamcinolone Ace... | 907,362 | [['E02.319.267.120'], ['M01.060.116'], ['D27.505.954.158'], ['D04.210.500.745.432.769.199.150', 'D04.210.500.908.093.150'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.251'], ['D04.210.500.908.093.250'], ['D05.750.078.280', 'D12.776.860.300.250'], ['G07.690.773.750'], ['A11.329.228']... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Norrie's disease: a prospective study of development. | Developmental progress, hearing, and dysmorphic features were monitored prospectively in eight babies with Norrie's disease (an X linked form of congenital blindness believed to be associated with mental retardation, regression, sensorineural deafness, and dysmorphic features) and in six congenitally blind peers during... | ['Blindness', 'Child Development', 'Genetic Linkage', 'Hearing Disorders', 'Hearing Tests', 'Humans', 'Infant', 'Infant, Newborn', 'Language Tests', 'Male', 'Prospective Studies', 'Psychomotor Performance', 'X Chromosome'] | 2,604,418 | [['C10.597.751.941.162', 'C11.966.075', 'C23.888.592.763.941.162'], ['F01.525.200', 'G07.345.374.750'], ['G05.348'], ['C09.218.458', 'C10.597.751.418', 'C23.888.592.763.393'], ['E01.370.382.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['F04.711.513.240'], ['E05.318.372.5... | ['Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Adolescents' experiences using the contraceptive patch versus pills. | STUDY OBJECTIVE: To compare use of the weekly transdermal contraceptive patch (patch) with daily combined hormonal contraceptive pills (pills) in adolescents.DESIGN: Prospective longitudinal study of adolescents' self-selected (non-randomized) use of the patch or pills.SETTING: Urban, university hospital-affiliated, ad... | ['Adolescent', 'Affect', 'Contraceptive Agents, Female', 'Contraceptives, Oral', 'Estrogens', 'Ethinyl Estradiol', 'Female', 'Humans', 'Levonorgestrel', 'Longitudinal Studies', 'Menstruation', 'Norgestrel', 'Patient Satisfaction', 'Prospective Studies', 'Quality of Life', 'Surveys and Questionnaires', 'Transdermal Patc... | 21,454,110 | [['M01.060.057'], ['F01.470.047'], ['D27.505.696.875.360.276', 'D27.505.954.705.360.276'], ['D27.505.696.875.360.276.210', 'D27.505.954.705.360.276.210'], ['D27.505.696.399.472.277'], ['D04.210.500.668.651.568.291', 'D06.472.334.851.437.968.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D04.210.500.668.651.6... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]'] | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
[Study on micrometastases in pelvic lymph nodes detected by real-time reverse transcriptase polymerase chain reaction with clinically localized prostate cancer before radical prostatectomy]. | OBJECTIVE: To clarify the significance of micrometastases in pelvic lymph nodes in patients with neoadjuvant hormonal therapy (NHT) before radical prostatectomy (RP).METHODS: Twenty-one patients with clinically localized prostate cancer who received NHT between August 2007 and March 2010 were observed. The patients wer... | ['Aged', 'Humans', 'Lymph Nodes', 'Lymphatic Metastasis', 'Male', 'Middle Aged', 'Pelvis', 'Polymerase Chain Reaction', 'Preoperative Care', 'Prognosis', 'Prostate-Specific Antigen', 'Prostatic Neoplasms', 'RNA, Messenger'] | 21,176,672 | [['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A10.549.400', 'A15.382.520.604.412'], ['C04.697.650.560', 'C23.550.727.650.560'], ['M01.060.116.630'], ['A01.923.600'], ['E05.393.620.500'], ['E02.760.795', 'E04.604.750', 'N02.421.585.795'], ['E01.789'], ['D08.811.277.656.300.760.442.750', 'D08.8... | ['Named Groups [M]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Structural model of the R state of Escherichia coli aspartate transcarbamoylase with substrates bound. | The allosteric enzyme aspartate transcarbamoylase (ATCase) exists in two conformational states. The enzyme, in the absence of substrates is primarily in the low-activity T state, is converted to the high-activity R state upon substrate binding, and remains in the R state until substrates are exhausted. These conformati... | ['Allosteric Site', 'Arginine', 'Aspartate Carbamoyltransferase', 'Binding Sites', 'Carbamyl Phosphate', 'Catalysis', 'Catalytic Domain', 'Crystallography, X-Ray', 'Escherichia coli', 'Leucine', 'Molecular Conformation', 'Protein Binding', 'Protein Conformation', 'Protein Structure, Tertiary', 'Substrate Specificity'] | 17,603,076 | [['G02.111.570.120.147'], ['D12.125.068.050', 'D12.125.095.104', 'D12.125.142.087'], ['D08.811.641.500', 'D08.811.913.555.275.200'], ['G02.111.570.120'], ['D02.241.081.251.145', 'D02.705.400.100'], ['G02.130'], ['G02.111.570.120.704', 'G02.111.570.820.709.275.750.188'], ['E05.196.309.742.225'], ['B03.440.450.425.325.30... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
PAK1 hyperactivation is sufficient for mammary gland tumor formation. | Emerging data suggest that p21-activated kinase 1 (Pak1), a downstream signaling molecule of the small GTPases, growth factors, and lipid signaling, is upregulated or hyperactivated in human breast cancer. Until now, however, no direct causative role had been found for Pak1 in mammary tumor formation. We therefore soug... | ['Animals', 'Antigens, Polyomavirus Transforming', 'Disease Models, Animal', 'Disease Progression', 'Enzyme Activation', 'Estrogen Receptor alpha', 'Humans', 'MAP Kinase Kinase 1', 'MAP Kinase Kinase 2', 'Mammary Glands, Animal', 'Mammary Neoplasms, Animal', 'Mice', 'Mice, Inbred C57BL', 'Mice, Inbred DBA', 'Mice, Tran... | 16,331,248 | [['B01.050'], ['D12.776.624.664.520.090', 'D12.776.964.700.090', 'D23.050.285.062.090', 'D23.050.327.062.090'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['C23.550.291.656'], ['G02.111.263', 'G03.328'], ['D12.776.826.750.350.174'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.913.696.620.682.700.565.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Oligoclonal IgG band patterns in inflammatory demyelinating human and mouse diseases. | We evaluated oligoclonal IgG band (OCB) patterns obtained by analyzing paired cerebrospinal fluid (CSF) and serum samples of 77 patients with acute demyelinating encephalomyelitis (ADEM) and 411 patients with multiple sclerosis (MS). OCBs were searched with isoelectric focusing and capillary immunoblotting. CSF-restric... | ['Animals', 'Chi-Square Distribution', 'Encephalomyelitis, Acute Disseminated', 'Encephalomyelitis, Autoimmune, Experimental', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Mice', 'Middle Aged', 'Multiple Sclerosis', 'Myelin Proteolipid Protein', 'Oligoclonal Bands'] | 18,606,457 | [['B01.050'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['C10.114.375.225', 'C10.228.140.695.562.225', 'C10.314.350.225', 'C20.111.258.250.350'], ['C10.114.703.300', 'C10.228.140.695.562.250', 'C10.314.350.250', 'C20.111.258.625.300', 'E05.598.500.500.500'], ['E05.318... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Guided growth for ankle valgus. | BACKGROUND: Ankle valgus may be insidious and common in a variety of congenital conditions including clubfoot, neuromuscular disorders and others or acquired after fracture, osteotomies, or other manipulations of the lower extremity. This can cause hindfoot pronaton, resulting in lateral impingement and excessive shoe ... | ['Adolescent', 'Ankle Joint', 'Child', 'Clubfoot', 'Female', 'Follow-Up Studies', 'Humans', 'Joint Deformities, Acquired', 'Male', 'Orthopedic Procedures', 'Radiography', 'Range of Motion, Articular', 'Retrospective Studies', 'Treatment Outcome'] | 22,101,668 | [['M01.060.057'], ['A02.835.583.378.062'], ['M01.060.406'], ['C05.330.488.655.063', 'C05.330.495.681.063', 'C05.660.585.512.380.813.063', 'C16.131.621.585.512.500.681.063'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C05.... | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
High yield growth and purification of human parainfluenza type 3 virus and initial analysis of viral structural proteins. | Structural proteins from a large-plaque variant (LPV) of human parainfluenza type 3 virus were analysed by electrophoresis on Laemmli-type polyacrylamide gels. High virus concentrations were obtained by growth in BS-C-1 cells cultivated on microcarrier beads. Purification of the virus in composite equilibrium gradients... | ['Electrophoresis, Polyacrylamide Gel', 'Parainfluenza Virus 3, Human', 'Respirovirus', 'Viral Proteins', 'Virus Replication'] | 6,270,242 | [['E05.196.401.402', 'E05.301.300.319'], ['B04.820.480.937.600.650.700.735'], ['B04.820.480.937.600.650.700'], ['D12.776.964'], ['G06.920.925']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Efficacy and Safety of Pembrolizumab in Patients Enrolled in KEYNOTE-030 in the United States: An Expanded Access Program. | KEYNOTE-030 (ClinicalTrials.gov ID, NCT02083484) was a global expanded access program that allowed access to pembrolizumab, an antiprogrammed death 1 antibody, for patients with advanced melanoma before its regulatory approval. Patients with unresectable stage III/IV melanoma that progressed after standard-of-care ther... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Antibodies, Monoclonal, Humanized', 'Antineoplastic Agents', 'Clinical Trials as Topic', 'Drug Resistance, Neoplasm', 'Drug-Related Side Effects and Adverse Reactions', 'Exanthema', 'Fatigue', 'Female', 'Humans', 'Male', 'Melanoma', 'Middle Aged', 'Neoplasm Metastas... | 29,028,788 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D12.776.124.486.485.114.224.060', 'D12.776.124.790.651.114.224.060', 'D12.776.377.715.548.114.224.200'], ['D27.505.954.248'], ['E05.318.372.250.250', 'N05.715.360.330.250.250', 'N06.850.520.450.250.250'], ['G07.690.773.984.395'], ['C25.1... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
H3.3K4M destabilizes enhancer H3K4 methyltransferases MLL3/MLL4 and impairs adipose tissue development. | Histone 3 lysine 4 (H3K4) methyltransferases MLL3 and MLL4 (MLL3/4) are required for enhancer activation during cell differentiation, though the mechanism is incompletely understood. We have attempted to address this issue by generating two mouse lines: one expressing H3.3K4M, a lysine-4-to-methionine (K4M) mutation of... | ['Adipogenesis', 'Adipose Tissue', 'Animals', 'Enhancer Elements, Genetic', 'Histone-Lysine N-Methyltransferase', 'Histones', 'Mice', 'Mice, Transgenic', 'Muscle Development', 'Mutation', 'Protein Domains', 'Protein Stability', 'Sequence Deletion', 'Thermogenesis'] | 30,335,158 | [['G04.152.149'], ['A10.165.114'], ['B01.050'], ['G02.111.570.080.689.330', 'G05.360.080.689.330', 'G05.360.340.024.340.137.750.249'], ['D08.811.913.555.500.800.200.500'], ['D12.776.157.687.485', 'D12.776.660.720.485', 'D12.776.664.469'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.136.500', 'B01.050.150... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Transcervical double-balloon catheter as an alternative and salvage method for medical termination of pregnancy in midtrimester. | OBJECTIVE: Termination of pregnancy in midtrimester can be performed surgically or medically. The aim of this study was to evaluate the medical methods, and the additional efficacy of using a transcervical double-balloon catheter in midtrimester termination.MATERIALS AND METHODS: In this retrospective study, we include... | ['Abortion, Induced', 'Administration, Intravaginal', 'Adolescent', 'Adult', 'Catheters', 'Female', 'Humans', 'Labor, Induced', 'Middle Aged', 'Oxytocics', 'Oxytocin', 'Pregnancy', 'Pregnancy Trimester, Second', 'Retrospective Studies', 'Time Factors'] | 28,254,231 | [['E04.520.050'], ['E02.319.267.120.500'], ['M01.060.057'], ['M01.060.116'], ['E07.132'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.520.252.968'], ['M01.060.116.630'], ['D27.505.696.875.737', 'D27.505.954.705.737'], ['D06.472.699.631.692.433', 'D12.644.548.691.692.433'], ['G08.686.784.769'], ['G08.686.707.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Psychosis and water intoxication. | Three cases of psychosis, polydipsia, and water intoxication are presented as examples of a syndrome that is potentially unrecognized in psychiatric settings. Diagnostic and etiologic considerations, with particular attention to the syndrome of inappropriate antidiuretic hormone secretion (SIADH), are discussed through... | ['Adult', 'Diagnosis, Differential', 'Female', 'Humans', 'Hyponatremia', 'Inappropriate ADH Syndrome', 'Male', 'Middle Aged', 'Psychotic Disorders', 'Water Intoxication'] | 457,618 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Ras and mitogen-activated protein kinase kinase kinase-1 coregulate activator protein-1- and nuclear factor-kappaB-mediated gene expression in airway epithelial cells. | In 16HBE14o- human bronchial epithelial cells, maximal tumor necrosis factor (TNF)-alpha-induced interleukin (IL)-8 expression depends on the activation of two distinct signaling pathways, one constituted in part by activator protein (AP)-1 and the other by nuclear factor (NF)-kappaB. We examined the upstream signaling... | ['Bronchi', 'Cells, Cultured', 'Epithelial Cells', 'Gene Expression Regulation', 'Granulocyte-Macrophage Colony-Stimulating Factor', 'Humans', 'Interleukin-8', 'JNK Mitogen-Activated Protein Kinases', 'MAP Kinase Kinase Kinase 1', 'Mitogen-Activated Protein Kinases', 'Mutation', 'NF-kappa B', 'Promoter Regions, Genetic... | 12,600,818 | [['A04.411.125'], ['A11.251'], ['A11.436'], ['G05.308'], ['D12.644.276.374.410.240.375', 'D12.776.395.240.300', 'D12.776.467.374.410.240.375', 'D23.529.374.410.240.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.200.120.800', 'D12.644.276.374.465.312', 'D12.776.467.374.200.120.800', 'D12.776.4... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cluster pattern analysis of energy deposition sites for the brachytherapy sources 103Pd, 125I, 192Ir, 137Cs, and 60Co. | Analysing the pattern of energy depositions may help elucidate differences in the severity of radiation-induced DNA strand breakage for different radiation qualities. It is often claimed that energy deposition (ED) sites from photon radiation form a uniform random pattern, but there is indication of differences in RBE ... | ['Brachytherapy', 'Cesium Radioisotopes', 'Cluster Analysis', 'Cobalt Radioisotopes', 'Iodine Radioisotopes', 'Iridium Radioisotopes', 'Palladium', 'Radiotherapy Dosage'] | 25,170,775 | [['E02.815.150'], ['D01.268.549.125.500.300', 'D01.268.556.165.500.300', 'D01.496.180.300', 'D01.496.749.190', 'D01.552.528.160.500.300', 'D01.552.544.165.500.300'], ['E05.318.740.250', 'N05.715.360.750.200', 'N06.850.520.830.250'], ['D01.268.556.185.500.354', 'D01.268.956.155.500.354', 'D01.496.239.354', 'D01.496.749.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Temporal integration by stochastic recurrent network dynamics with bimodal neurons. | Temporal integration of externally or internally driven information is required for a variety of cognitive processes. This computation is generally linked with graded rate changes in cortical neurons, which typically appear during a delay period of cognitive task in the prefrontal and other cortical areas. Here, we pre... | ['Action Potentials', 'Animals', 'Models, Neurological', 'Nerve Net', 'Neural Inhibition', 'Neural Networks, Computer', 'Neurons', 'Nonlinear Dynamics', 'Stochastic Processes'] | 17,392,417 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['B01.050'], ['E05.599.395.642'], ['A08.511'], ['G07.265.755', 'G11.561.616'], ['G17.485', 'L01.224.050.375.605'], ['A08.675', 'A11.671'], ['E05.599.850', 'H01.548.675'], ['E05.318.740.996', 'G17.830', 'N05.715.360.750.770', 'N06.850.520.830.996']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Information Science [L]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Cues for health-related imagery in analogue worriers: a brief report. | The role of specific cues for eliciting fearful imagery in a sample of analogue worriers was examined. Picture, script and audiotape disease-related cues were presented to 12 nonworriers and 13 analogue worriers who worried about health and disease. In general, the picture and audiotape cues were most anxiety provoking... | ['Adaptation, Psychological', 'Adolescent', 'Adult', 'Anxiety', 'Arousal', 'Female', 'Humans', 'Imagination', 'Internal-External Control', 'Life Change Events', 'Male', 'Sick Role'] | 8,512,542 | [['F01.058'], ['M01.060.057'], ['M01.060.116'], ['F01.470.132'], ['F02.830.104', 'G11.561.035'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.188.634'], ['F01.829.379'], ['F01.829.458.410'], ['F01.829.316.616.751']] | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Effect of One-Week Salt Restriction on Blood Pressure Variability in Hypertensive Patients with Type 2 Diabetes. | BACKGROUND: Increased short-term blood pressure (BP) variability on 24-hour ambulatory BP monitoring (ABPM) is known to be a risk factor for cardiovascular events. However, very few studies have evaluated the effect of salt restriction on BP variability particularly in hypertensive patients with type 2 diabetes. This s... | ['Aged', 'Blood Pressure', 'Diabetes Mellitus, Type 2', 'Female', 'Humans', 'Hypertension', 'Male', 'Middle Aged', 'Prospective Studies', 'Sodium Chloride, Dietary'] | 26,731,185 | [['M01.060.116.100'], ['E01.370.600.875.249', 'G09.330.380.076'], ['C18.452.394.750.149', 'C19.246.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['M01.060.116.630'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['D01.857.650.705', 'D01.857.875.705... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Lipid peroxidation and phospholipase A2 activity in liposomes composed of unsaturated phospholipids: a structural basis for enzyme activation. | The effect of lipid peroxidation on membrane structure and phospholipase A2 activity was studied using liposomes composed of bovine liver phosphatidylcholine (PC) and phosphatidylethanolamine (PE). The phospholipids were mixed at set ratios and sonicated to yield small unilamellar vesicles. The liposome preparations we... | ['Animals', 'Cattle', 'Enzyme Activation', 'Fatty Acids', 'Lipid Peroxides', 'Liposomes', 'Liver', 'Phosphatidylcholines', 'Phosphatidylethanolamines', 'Phospholipases', 'Phospholipases A', 'Phospholipases A2', 'Phospholipids', 'Structure-Activity Relationship'] | 3,401,498 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['G02.111.263', 'G03.328'], ['D10.251'], ['D01.248.497.158.685.750.637', 'D01.339.431.374.637', 'D01.650.550.750.600', 'D02.389.338.450', 'D10.440'], ['D25.479.517', 'D26.255.260.517', 'J01.637.051.479.517', 'J01.637.087.500.517'], ['A03.620'], ['D10.570.755.375.76... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Healthy children show gender differences in correlations between nonverbal cognitive ability and brain activation during visual perception. | Humans perceive textual and nontextual information in visual perception, and both depend on language. In childhood education, students exhibit diverse perceptual abilities, such that some students process textual information better and some process nontextual information better. These predispositions involve many facto... | ['Adolescent', 'Attention', 'Brain', 'Brain Mapping', 'Child', 'Cognition', 'Female', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Sex Factors', 'Visual Perception'] | 24,937,269 | [['M01.060.057'], ['F02.830.104.214'], ['A08.186.211'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['M01.060.406'], ['F02.463.188'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['N05.715.350.675', 'N06.850.490.875'], ['F02.463.593.932']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The complete mitochondrial genome of the Sorex araneus. | The Sorex araneus (common shrew), a member of the Soricidae family, is the most common shrew throughout Northern Europe. The region includes Great Britain, but excludes Ireland. Herein, we first publish the complete mitochondrial genome of S. araneus. The mitogenome is 16 887 bp in length, which contains 24 tRNA genes,... | ['Animals', 'DNA, Mitochondrial', 'Genome, Mitochondrial', 'Phylogeny', 'RNA, Ribosomal', 'RNA, Transfer', 'Shrews', 'Whole Genome Sequencing'] | 26,328,473 | [['B01.050'], ['D13.444.308.283.225'], ['G05.360.340.360'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['D13.444.735.686'], ['D13.444.735.757'], ['B01.050.150.900.649.313.961.751'], ['E05.393.760.700.825']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Hypoxia-inducible mammalian gene expression analyzed in vivo at a TATA-driven promoter and at an initiator-driven promoter. | We have analyzed protein-DNA interactions in vivo at transcriptional control elements for two hypoxia-inducible genes in mouse hepatoma cells. The promoter for the phosphoglycerate kinase 1 (PGK1) gene contains an initiator element, but no TATA sequence, whereas the promoter for the glucose transporter 1 (Glut1) gene c... | ['Animals', 'Aryl Hydrocarbon Receptor Nuclear Translocator', 'Base Sequence', 'Binding Sites', 'Cell Hypoxia', 'DNA Primers', 'DNA-Binding Proteins', 'Enhancer Elements, Genetic', 'Gene Expression Regulation, Enzymologic', 'Gene Expression Regulation, Neoplastic', 'Glucose Transporter Type 1', 'Liver Neoplasms, Experi... | 9,726,995 | [['B01.050'], ['D12.776.157.530.750.100', 'D12.776.260.103.625.500', 'D12.776.543.585.750.100', 'D12.776.930.125.625.500'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G02.111.570.120'], ['G03.197.300', 'G04.270.300'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['D12.776.260'], ['G02.1... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
The genetics and genomics of the drought response in Populus. | The genetic nature of tree adaptation to drought stress was examined by utilizing variation in the drought response of a full-sib second generation (F(2)) mapping population from a cross between Populus trichocarpa (93-968) and P. deltoides Bart (ILL-129) and known to be highly divergent for a vast range of phenotypic ... | ['Disasters', 'Expressed Sequence Tags', 'Genome, Plant', 'Populus', 'Quantitative Trait Loci', 'RNA, Messenger', 'Species Specificity'] | 17,005,011 | [['N06.230.100'], ['G05.360.340.024.340.137.275'], ['G05.360.340.365'], ['B01.650.940.800.575.912.250.859.797.875.453'], ['G05.360.340.024.380.937'], ['D13.444.735.544'], ['G16.824']] | ['Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Quality assurance strategies in U.S. and Canadian psychiatry. | Quality Assurance Strategies in Psychiatry and Medicine in general have developed rapidly and have been applied widely in the last few years, particularly in the United States. This paper reviews some of those developments both from a methodological and a socio-political point of view. The relevance to the Canadian sce... | ['Accreditation', 'Canada', 'Cost-Benefit Analysis', 'Humans', 'Outcome and Process Assessment, Health Care', 'Peer Review', 'Politics', 'Professional Review Organizations', 'Psychiatry', 'Quality of Health Care', 'United States'] | 111,797 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
TDAG51 (T-Cell Death-Associated Gene 51) Is a Key Modulator of Vascular Calcification and Osteogenic Transdifferentiation of Arterial Smooth Muscle Cells. | OBJECTIVE: Cardiovascular disease is the primary cause of mortality in patients with chronic kidney disease. Vascular calcification (VC) in the medial layer of the vessel wall is a unique and prominent feature in patients with advanced chronic kidney disease and is now recognized as an important predictor and independe... | ['Aged', 'Animals', 'Cell Transdifferentiation', 'Cells, Cultured', 'Cholecalciferol', 'Core Binding Factor Alpha 1 Subunit', 'Disease Models, Animal', 'Female', 'Gene Expression Regulation', 'Humans', 'Hyperphosphatemia', 'Male', 'Mice, Inbred C57BL', 'Mice, Knockout', 'Muscle, Smooth, Vascular', 'Myocytes, Smooth Mus... | 32,434,409 | [['M01.060.116.100'], ['B01.050'], ['G04.356'], ['A11.251'], ['D04.210.500.247.222.159', 'D04.210.500.247.808.146', 'D04.210.500.812.768.196', 'D10.570.938.146'], ['D12.776.930.155.200.100'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['G05.308'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C18.452.750.199']... | ['Named Groups [M]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Single atom modification leads to enhanced nucleotide self-assembly: the role of cation bridging. | We report that the ability of disodium 5'-deoxy-5'-thioguanosine-5'-monophosphate, Na(2)(5'-GSMP), to self-associate into a helical G-quadruplex structure in aqueous solution at pH 8 is significantly higher than that of disodium guanosine-5'-monophosphate, Na(2)(5'-GMP), which supports our earlier hypothesis regarding ... | ['Cations', 'G-Quadruplexes', 'Guanosine', 'Guanosine Monophosphate'] | 21,336,356 | [['D01.248.497.300'], ['G02.111.570.820.486.550', 'G05.360.580.550'], ['D03.633.100.759.590.454', 'D13.570.583.454', 'D13.570.800.453'], ['D03.633.100.759.646.454.400', 'D13.695.667.454.400', 'D13.695.827.426.400']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Pathomorphological characteristics of experimental toxemia induced by thermostable Yersinia pseudotuberculosis toxin. | Pathogenic properties of thermostable toxin responsible for pathogenicity of Yersinia pseudotuberculosis were experimentally studied. The toxin exerted a pronounced polyorgan cytopathogenic effect with predominating degenerative destructive changes and membranolytic effect on cell ultrastructure of parenchymatous organ... | ['Animals', 'Bacterial Toxins', 'Capillaries', 'Disease Models, Animal', 'Enterotoxins', 'Gallbladder', 'Heart', 'Kidney', 'Liver', 'Lung', 'Mice', 'Myocardium', 'Spleen', 'Toxemia', 'Yersinia pseudotuberculosis'] | 11,182,834 | [['B01.050'], ['D23.946.123'], ['A07.015.461.165'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['D23.946.330'], ['A03.159.439'], ['A07.541'], ['A05.810.453'], ['A03.620'], ['A04.411'], ['B01.050.150.900.649.313.992.635.505.500'], ['A02.633.580', 'A07.541.704', 'A10.690.552.750'], ['A10.549.700', 'A15.382.520.604.70... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Caregiver exposure to malaria social and behaviour change messages can improve bed net use among children in an endemic country: secondary analysis of the 2015 Nigeria Malaria Indicator Survey. | BACKGROUND: To reduce the malaria burden in Nigeria, the National Malaria Strategic Plan (NMSP) 2014‒2020 calls for the scale-up of prevention and treatment interventions, including social and behaviour change (SBC). SBC interventions can increase awareness and improve the demand for and uptake of malaria interventions... | ['Adolescent', 'Adult', 'Caregivers', 'Child, Preschool', 'Cross-Sectional Studies', 'Female', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Infant', 'Insecticide-Treated Bednets', 'Logistic Models', 'Malaria', 'Male', 'Middle Aged', 'Mosquito Control', 'Nigeria', 'Odds Ratio', 'Social Behavior', 'Young Adult'] | 30,954,073 | [['M01.060.057'], ['M01.060.116'], ['M01.085', 'M01.526.485.200', 'N02.360.200'], ['M01.060.406.448'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['F01.100.150.500', 'N05.300.150.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['E07.700.510.500'], ['E05.318.7... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Effects of levocarnitine on brachial-ankle pulse wave velocity in hemodialysis patients: a randomized controlled trial. | BACKGROUND AND AIMS: Atherosclerotic cardiovascular disease is the most common cause of mortality in patients with end-stage kidney disease. Chronic kidney disease patients often exhibit a deficiency in L-carnitine due to loss during hemodialysis (HD). We studied the effects of L-carnitine supplementation on brachial-a... | ['Administration, Oral', 'Aged', 'Ankle Brachial Index', 'Atherosclerosis', 'Biomarkers', 'Blood Flow Velocity', 'Carnitine', 'Dietary Supplements', 'Female', 'Humans', 'Kidney Failure, Chronic', 'Male', 'Middle Aged', 'Prospective Studies', 'Pulsatile Flow', 'Renal Dialysis'] | 25,533,009 | [['E02.319.267.100'], ['M01.060.116.100'], ['E01.370.370.140.049'], ['C14.907.137.126.307'], ['D23.101'], ['E01.370.370.130', 'G09.330.380.630.080'], ['D02.092.877.883.099'], ['G07.203.300.456', 'J02.500.456'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.777.419.780.750.500', 'C13.351.968.419.780.750.500'], ... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
The surgical treatment of breast cancer in the elderly: a single institution comparative review of 5235 patients with 1028 patients ?70 years. | As the wave of the baby boomers shifts the age demographic of patients, the current surgical management of breast cancer in elderly women (?70 years of age) becomes relevant because deviation from standard treatment often occurs in this group. The purpose of this study was to determine the operative mortality when trea... | ['Adult', 'Aged', 'Aged, 80 and over', 'Breast Neoplasms', 'Carcinoma, Intraductal, Noninfiltrating', 'Female', 'Humans', 'Logistic Models', 'Mastectomy', 'Mastectomy, Segmental', 'Middle Aged', 'Retrospective Studies'] | 22,957,995 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C04.588.180', 'C17.800.090.500'], ['C04.557.470.200.025.275', 'C04.557.470.200.240.187.250', 'C04.557.470.615.275'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.525', 'E05.318.740.600.800.450', 'E05.318.740.750.450', 'E05.599.835.8... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
OncotypeDX Recurrence Score Does Not Predict Nodal Burden in Clinically Node Negative Breast Cancer Patients. | BACKGROUND: OncotypeDX recurrence score (RS)® has been found to predict recurrence and disease-free survival in patients with node negative breast cancer. Whether RS is useful in guiding locoregional therapy decisions is unclear. We sought to evaluate the relationship between RS and lymph node burden.METHODS: Patients ... | ['Adult', 'Aged', 'Aged, 80 and over', 'Biomarkers, Tumor', 'Breast Neoplasms', 'Carcinoma, Ductal, Breast', 'Female', 'Follow-Up Studies', 'Gene Expression Profiling', 'Genetic Testing', 'Humans', 'Lymphatic Metastasis', 'Middle Aged', 'Neoplasm Recurrence, Local', 'Prognosis', 'Prospective Studies', 'Retrospective St... | 30,556,120 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D23.101.140'], ['C04.588.180', 'C17.800.090.500'], ['C04.557.470.200.025.232.500', 'C04.557.470.615.132.500', 'C04.588.180.390', 'C17.800.090.500.390'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['E05.393.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A two-compartment model of the human retina. | PURPOSE: In this article we question a basic concept in retinal pathology, which views the retina as composed primarily of neural elements, in a single compartment.METHODS: We suggest an alternative approach, centering on the epithelial-glial elements of the retina, dividing the retina into two distinct compartments. T... | ['Animals', 'Humans', 'Models, Biological', 'Retina', 'Retinal Diseases', 'Vision, Ocular'] | 15,082,112 | [['B01.050'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.395'], ['A09.371.729'], ['C11.768'], ['F02.830.816.964', 'G02.111.820.480.900', 'G04.835.480.900', 'G11.561.790.964', 'G14.935']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[The immunomodulating action of interferons in their combined use with a typhus vaccine]. | The data of the comparative study of the immunomodulating action of donor interferon and reaferon in experiments with typhus vaccine, used as an experimental model, on monkeys of different species and guinea pigs are presented. One of the main properties of interferons, besides their antiviral activity, is their capaci... | ['Adjuvants, Immunologic', 'Animals', 'Antibody Formation', 'Drug Evaluation, Preclinical', 'Drug Therapy, Combination', 'Guinea Pigs', 'Humans', 'Immunization', 'Interferon Type I', 'Interferon alpha-2', 'Interferon-alpha', 'Macaca fascicularis', 'Macaca mulatta', 'Recombinant Proteins', 'Rickettsia prowazekii', 'Rick... | 8,067,148 | [['D27.505.696.477.067'], ['B01.050'], ['G12.450.050.370.250'], ['E05.290.750', 'E05.337.550'], ['E02.319.310'], ['B01.050.150.900.649.313.992.550'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.095.465.425.400', 'E05.478.550', 'N02.421.726.758.310', 'N06.850.780.200.425', 'N06.850.780.680.310'], ['D12.644.27... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
E-cadherin interactions are required for Langerhans cell differentiation. | Human skin contains the following two distinct DC subsets: (i) Langerhans cells (LCs), expressing Langerin but not DC-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN), are predominantly localized in the epidermis; and (ii) dermal DCs, expressing DC-SIGN but not Langerin, are observed mainly in ... | ['Antibodies, Blocking', 'Antigens, CD', 'Cadherins', 'Cell Adhesion Molecules', 'Cell Communication', 'Cell Differentiation', 'Cells, Cultured', 'Coculture Techniques', 'Cytokines', 'Dermis', 'Epidermis', 'Humans', 'Keratinocytes', 'Langerhans Cells', 'Lectins, C-Type', 'Leukocytes, Mononuclear', 'Mannose-Binding Lect... | 23,135,957 | [['D12.776.124.486.485.114.143', 'D12.776.124.790.651.114.143', 'D12.776.377.715.548.114.143'], ['D23.050.301.264.035', 'D23.101.100.110'], ['D12.776.395.550.200.200', 'D12.776.543.550.200.200', 'D23.050.301.350.200'], ['D12.776.395.550.200', 'D12.776.543.550.200', 'D23.050.301.350'], ['G04.085'], ['G04.152'], ['A11.25... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Operative strategies for management of abdominal aortic gunshot wounds. | BACKGROUND: Although management of penetrating abdominal trauma has greatly improved, abdominal aortic gunshot wounds (AAGSWs) remain a highly lethal injury. Our experience with AAGSWs was reviewed to define operative strategies that may improve survival.METHODS: Forty-one patients with AAGSWs were treated between 1976... | ['Adult', 'Angioplasty', 'Aorta, Abdominal', 'Aortic Valve Stenosis', 'Female', 'Follow-Up Studies', 'Hemorrhage', 'Humans', 'Laparotomy', 'Male', 'Shock', 'Surgical Mesh', 'Survival Analysis', 'Thoracotomy', 'Time Factors', 'Treatment Outcome', 'Wounds, Gunshot'] | 8,862,376 | [['M01.060.116'], ['E02.148.050', 'E04.100.814.529.124', 'E04.502.382.124', 'E05.157.016'], ['A07.015.114.056.205'], ['C14.280.484.048.750', 'C14.280.955.249'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['C23.550.414'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Predation as the primary selective force in recurrent evolution of gigantism in Poecilozonites land snails in Quaternary Bermuda. | During the last half million years, pulses of gigantism in the anagenetic lineage of land snails of the subgenus Poecilozonites on Bermuda were correlated with glacial periods when lower sea level resulted in an island nearly an order of magnitude larger than at present. During those periods, the island was colonized b... | ['Animals', 'Bermuda', 'Biological Evolution', 'Body Size', 'Ecosystem', 'Extinction, Biological', 'Food Chain', 'Fossils', 'Selection, Genetic', 'Snails', 'Vertebrates'] | 20,554,560 | [['B01.050'], ['Z01.639.040.390'], ['G05.045', 'G16.075'], ['E01.370.600.115.100.160', 'E05.041.124.160', 'G07.100.100.160', 'G07.345.249.314'], ['G16.500.275.157', 'N06.230.124'], ['G16.510'], ['G16.500.275.157.250', 'N06.230.124.250'], ['I01.076.368.584.311'], ['G05.783'], ['B01.050.500.644.400.750'], ['B01.050.150.9... | ['Organisms [B]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Inhibition of photophosphorylation by ATP and the role of magnesium in photophosphorylation. | ATP and pyrophosphate at high concentration (greater than 1 mM) inhibited photophosphorylation of isolated spinach chloroplasts in the normal salt medium and did not cause stimulation of electron transport. The inhibition of photophosphorylation by ATP or pyrophosphate was shown to be abolished by the addition of exces... | ['Adenosine Diphosphate', 'Adenosine Triphosphate', 'Binding Sites', 'Chloroplasts', 'Kinetics', 'Magnesium', 'Phosphates', 'Photophosphorylation', 'Plants'] | 1,247,601 | [['D03.633.100.759.646.138.124', 'D13.695.667.138.124', 'D13.695.827.068.124'], ['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['G02.111.570.120'], ['A11.284.430.214.190.875.700.140'], ['G01.374.661', 'G02.111.490'], ['D01.268.552.437', 'D01.268.557.500', 'D01.552.547.500'], ['D01.029.26... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Target organ damage and associated clinical conditions among Nigerians with treated hypertension. | AIM: Systemic hypertension is the commonest noncommunicable disease in Nigeria. Hypertension is linked with certain target organ damage (TOD) and associated clinical conditions (ACC). This study assessed the extent, pattern and predictors of TOD/ACC in patients with hypertension in Nigeria.METHODS: The study was carrie... | ['Adult', 'Aged', 'Antihypertensive Agents', 'Blood Pressure', 'Diabetic Nephropathies', 'Female', 'Heart Diseases', 'Humans', 'Hypertension', 'Kidney Diseases', 'Male', 'Middle Aged', 'Nigeria', 'Prevalence', 'Retinal Diseases', 'Systole'] | 15,915,275 | [['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.411.162'], ['E01.370.600.875.249', 'G09.330.380.076'], ['C12.777.419.192', 'C13.351.968.419.192', 'C19.246.099.875'], ['C14.280'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['C12.777.419', 'C13.351.968.419'], ['M01.060.116.630'], ['Z01.058.290... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
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