Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Chronic Toxicity Assessment of 2'-O-Methoxyethyl Antisense Oligonucleotides in Mice. | Advances in antisense oligonucleotide (ASO) chemistry and screening have enabled the design and selection of molecules that are optimized for a particular therapeutic application in terms of both potency and tolerability. The most-well studied of the chemically modified ASOs are single-stranded antisense inhibitors wit... | ['Alanine Transaminase', 'Animals', 'Liver', 'Mice', 'Oligonucleotides, Antisense'] | 29,708,844 | [['D08.811.913.477.700.100'], ['B01.050'], ['A03.620'], ['B01.050.150.900.649.313.992.635.505.500'], ['D13.150.480', 'D13.444.600.150.640', 'D13.695.578.424.480', 'D27.720.470.530.600.150.640']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Orchiectomy and delayed radiotherapy as treatment for prostatic carcinoma. A 10-year survey. | One hundred and fifty patients with carcinoma of the prostate treated between 1967 and 1982 have been reviewed. Thirty-three patients were treated with stilboestrol alone, 36 by orchiectomy alone and in 81 cases radical radiotherapy was given to the prostate (and in 10 of the 81 cases to the regional and para-aortic ly... | ['Aged', 'Diethylstilbestrol', 'Humans', 'Male', 'Middle Aged', 'Orchiectomy', 'Prostatic Neoplasms'] | 3,756,411 | [['M01.060.116.100'], ['D02.455.426.559.389.150.700.725.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E04.270.282.679', 'E04.950.165.679', 'E04.950.774.860.618'], ['C04.588.945.440.770', 'C12.294.260.750', 'C12.294.565.625', 'C12.758.409.750']] | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Local Hypothermia as a Radioprotector of the Rectal Wall During Prostate Stereotactic Body Radiation Therapy. | PURPOSE: To compare the single-fraction dose-related incidence of rectal obstruction and/or bleeding in normothermic and hypothermic rectums of a rat model.METHODS AND MATERIALS: A 1.9-cm length of rectum was irradiated with a single fraction in 57 Sprague-Dawley rats using a dedicated image-guided small animal irradia... | ['Animals', 'Body Temperature', 'Female', 'Gastrointestinal Hemorrhage', 'Hypothermia, Induced', 'Intestinal Obstruction', 'Male', 'Monte Carlo Method', 'Organ Sparing Treatments', 'Radiation Dosage', 'Radiation Injuries, Experimental', 'Radiation Protection', 'Radiosurgery', 'Rats', 'Rats, Sprague-Dawley', 'Rectal Dis... | 28,258,897 | [['B01.050'], ['E01.370.600.875.374', 'G07.110'], ['C06.405.227', 'C23.550.414.788'], ['E02.258.750'], ['C06.405.469.531'], ['E05.318.740.525', 'L01.906.394.422', 'N05.715.360.750.540', 'N06.850.520.830.525'], ['E02.674'], ['E05.799.513', 'G01.750.740', 'N06.850.810.250'], ['C26.733.720', 'E05.598.500.750', 'G01.750.74... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Information Science [L]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Spectrum of endoscopic findings and therapy in patients with upper gastrointestinal symptoms after laparoscopic bariatric surgery. | BACKGROUND: More should be known about the spectrum of endoscopic abnormalities and treatments in patients with upper gastrointestinal (UGI) symptoms after laparoscopic bariatric surgery.METHODS: Patients referred for endoscopic evaluation of UGI symptoms after laparoscopic bariatric surgery were studied. Clinical mani... | ['Adult', 'Cohort Studies', 'Endoscopy', 'Female', 'Gastric Bypass', 'Gastrointestinal Diseases', 'Gastroplasty', 'Humans', 'Male', 'Middle Aged', 'Obesity, Morbid', 'Retrospective Studies', 'Treatment Outcome'] | 16,989,710 | [['M01.060.116'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E01.370.388.250', 'E04.502.250'], ['E02.650.500.062.249', 'E04.035.398.385', 'E04.062.249', 'E04.210.457.430'], ['C06.405'], ['E02.650.500.062.750', 'E04.062.750', 'E04.210.485'], ['B01.050.150.900.649.313.988.400.112.400... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Prediction of pesticide concentrations found in rivers in the UK. | SWATCATCH is a distributed model combined with databases within a GIS as the POPPIE system to predict pesticide concentrations in rivers at the catchment outlet. The model was evaluated against a dataset of pesticide concentrations in rivers of England and Wales. More than 2000 individual analyses in each of the years ... | ['Adsorption', 'England', 'Environmental Monitoring', 'Forecasting', 'Fresh Water', 'Half-Life', 'Models, Biological', 'Pesticides', 'Sampling Studies', 'Soil Pollutants', 'Time Factors', 'Wales', 'Water Pollutants, Chemical', 'Water Pollution, Chemical'] | 11,975,184 | [['G01.030', 'G02.020'], ['Z01.542.363.300'], ['N06.850.460.350.080', 'N06.850.780.375'], ['I01.320'], ['G16.500.275.280', 'N06.230.232'], ['G01.910.405'], ['E05.599.395'], ['D27.720.031.700', 'D27.888.723'], ['E05.318.372.875', 'N05.715.360.330.875', 'N06.850.520.450.875'], ['D27.888.284.756'], ['G01.910.857'], ['Z01.... | ['Phenomena and Processes [G]', 'Geographicals [Z]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
[Characteristics of central acute resetting of high threshold baroreflex in rabbit's aortic nerves]. | Experiments were performed on 37 urethane-anesthetized rabbits. The aortic nerves, carotid sinus nerves and vagus nerves were cut, MAP and renal sympathetic nerve activity (RSNA) were recorded. The conditional stimulation CSc (0.5 ms, 10 Hz, 4-6V, 5 min) was used to mimic the information of baroreflex non-medullated af... | ['Animals', 'Aorta', 'Electric Stimulation', 'Female', 'Male', 'Nerve Fibers', 'Nerve Fibers, Myelinated', 'Pressoreceptors', 'Rabbits', 'Reflex', 'Sensory Thresholds'] | 1,788,559 | [['B01.050'], ['A07.015.114.056'], ['E05.723.402'], ['A08.675.542', 'A11.671.501'], ['A08.675.542.512', 'A11.671.501.512', 'A11.671.514'], ['A08.675.650.915.750.750', 'A08.800.050.800.900.700', 'A08.800.950.750.750', 'A11.671.650.915.750.750'], ['B01.050.150.900.649.313.968.700'], ['E01.370.376.550.650', 'E01.370.600.5... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Influence of sex on surgical time in primary total knee arthroplasty. | BACKGROUND: Total knee arthroplasty (TKA) is widely recognized as an effective procedure for treatment of knee arthritis. However, there have been documented differences between men and women with respect to anatomic variability, timing of access to surgical care and surgical outcomes. We examined the influence of sex ... | ['Aged', 'Arthroplasty, Replacement, Knee', 'Arthroscopy', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Middle Aged', 'Osteoarthritis, Knee', 'Retrospective Studies', 'Risk Factors', 'Sex Factors', 'Time Factors', 'Treatment Outcome'] | 20,646,400 | [['M01.060.116.100'], ['E04.555.110.110.115', 'E04.650.110.115', 'E04.680.101.110.115'], ['E01.370.388.250.070', 'E04.502.250.070', 'E04.555.113'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C05.550.1... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[The Cyanocobalamin Reference Standard (Control 931) of the National Institute of Health Sciences]. | Raw cyanocobalamin material was tested for preparation of the "Cyanocobalamin Reference Standard (Control 931)". Analytical data obtained were as follows: loss on drying, 4.2%; infrared spectrum, the same as that of the JP Cyanocobalamin Reference Standard (Control 901); thin-layer chromatography, four impurities were ... | ['Chemical Phenomena', 'Chemistry, Physical', 'Government Agencies', 'Japan', 'Pharmacopoeias as Topic', 'Vitamin B 12'] | 8,854,923 | [['G02'], ['H01.181.529'], ['I01.409.418', 'N03.540.400'], ['Z01.252.474.463', 'Z01.639.595'], ['L01.178.682.192.836.749'], ['D03.383.129.578.840.437.777', 'D03.633.400.909.437.777', 'D04.345.783.437.777']] | ['Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Geographicals [Z]', 'Information Science [L]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 |
Maternal views and experiences regarding repeat Caesarean section. | OBJECTIVE: The aim was to determine maternal views and experiences regarding repeat caesarean section.METHODS: A pretested and validated semi-structured questionnaire was administered to women with prior cesarean section by trained research assistants and resident doctors; anonymity and confidentiality were strictly ob... | ['Adult', 'Cesarean Section, Repeat', 'Cross-Sectional Studies', 'Family', 'Female', 'Humans', 'Pregnancy', 'Surveys and Questionnaires'] | 25,966,720 | [['M01.060.116'], ['E04.520.252.500.150'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['F01.829.263', 'I01.880.853.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G08.686.784.769'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Late Gadolinium Enhancement in Patients With Hypertrophic Cardiomyopathy and Preserved Systolic Function. | BACKGROUND: A high proportion of patients with hypertrophic cardiomyopathy (HCM) have evidence of late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR).OBJECTIVES: This study sought to assess the incremental prognostic utility of LGE in patients with HCM.METHODS: We studied 1,423 consecutive low-/interm... | ['Aged', 'Aged, 80 and over', 'Cardiomyopathy, Hypertrophic', 'Contrast Media', 'Echocardiography', 'Female', 'Follow-Up Studies', 'Gadolinium', 'Humans', 'Magnetic Resonance Imaging, Cine', 'Male', 'Middle Aged', 'Retrospective Studies', 'Stroke Volume', 'Systole'] | 30,115,224 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['C14.280.238.100', 'C14.280.484.048.750.070.160'], ['D27.505.259.500', 'D27.720.259'], ['E01.370.350.130.750', 'E01.370.350.850.220', 'E01.370.370.380.220'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['D01.268.558.362.484',... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Determination of the absolute configuration of peptide natural products by using stable isotope labeling and mass spectrometry. | Structure elucidation of natural products including the absolute configuration is a complex task that involves different analytical methods like mass spectrometry, NMR spectroscopy, and chemical derivation, which are usually performed after the isolation of the compound of interest. Here, a combination of stable isotop... | ['Biological Products', 'Isotope Labeling', 'Magnetic Resonance Spectroscopy', 'Mass Spectrometry', 'Peptides', 'Peptides, Cyclic', 'Stereoisomerism'] | 22,266,804 | [['D20.215'], ['E05.522'], ['E05.196.867.519'], ['E05.196.566'], ['D12.644'], ['D04.345.566', 'D12.644.641'], ['G02.607.445.682']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Histiocytic sarcoma of the brain in childhood. | CT-scan findings of the brain in two children with true histiocytic sarcoma are described as well as their changes during therapy. Clinical features and differential diagnosis on CT-scan examination are discussed. Follow-up CT-scan during therapy is of value as an indicator of the response to therapy and possibly the l... | ['Brain Abscess', 'Brain Neoplasms', 'Child', 'Diagnosis, Differential', 'Humans', 'Lymphoma, Non-Hodgkin', 'Male', 'Tomography, X-Ray Computed'] | 3,595,622 | [['C01.207.090', 'C01.830.025.160', 'C10.228.140.116', 'C10.228.228.090'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['M01.060.406'], ['E01.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.386.480', 'C15.604.515.569.480', 'C20.683.515.761.480'], ['E01.370.350.350.810', 'E01.370.350... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A question sheet to encourage written consultation questions. | PROBLEM: Interviews with parents and children attending a hospital paediatric neurology clinic indicated they had difficulties in asking questions during consultations.AIM: To set up a process to enable parents and children to get the information they wanted.BACKGROUND AND SETTING: Two paediatric neurology clinics in s... | ['Child', 'Disabled Children', 'Epilepsy', 'Humans', 'Interviews as Topic', 'Migraine Disorders', 'Parents', 'Patient Satisfaction', 'Physician-Patient Relations', 'Recurrence'] | 10,848,369 | [['M01.060.406'], ['M01.150.200'], ['C10.228.140.490'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.420', 'L01.399.250.520', 'N05.715.360.300.400', 'N06.850.520.308.420'], ['C10.228.140.546.399.750'], ['F01.829.263.500.320', 'I01.880.853.150.500.340', 'M01.620'], ['F01.100.150.750.625', 'F01.145.488.... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 0 |
New platinum(II) and palladium(II) complexes with substituted terpyridine ligands: synthesis and characterization, cytotoxicity and reactivity towards biomolecules. | A series of palladium(II) (1-3) and platinum(II) chloride complexes (4 and 5) with 2,2':6',2″-terpyridine (terpy) derivatives substituted at the 4' position, was synthesized and fully characterized. Single crystal X-ray diffraction analysis of complexes 2, 3 and 5 showed tridentate coordination of the 4'-substituted te... | ['Antineoplastic Agents', 'Cell Line, Tumor', 'Cell Proliferation', 'Cisplatin', 'Coordination Complexes', 'Dose-Response Relationship, Drug', 'Drug Screening Assays, Antitumor', 'Humans', 'Molecular Structure', 'Palladium', 'Platinum', 'Pyridines', 'Structure-Activity Relationship'] | 30,367,340 | [['D27.505.954.248'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.161.750', 'G07.345.249.410.750'], ['D01.210.375', 'D01.625.125', 'D01.710.100'], ['D01.234', 'D02.257'], ['G07.690.773.875', 'G07.690.936.500'], ['E01.370.225.500.388', 'E05.200.500.388', 'E05.242.417', 'E05.337.550.200'], ['B01.050.150.900.649.313.988... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
New insight into left ventricular function in tricuspid atresia after total cavopulmonary connection: a three-dimensional echocardiographic study. | BACKGROUND: In patients with tricuspid atresia palliated by construction of a total cavopulmonary connection, both pulmonary and systemic circulations depend on the performance of the dominant left ventricle. When estimating the volume of such ventricles using cross-sectional echocardiography, it is necessary to make a... | ['Adolescent', 'Cardiac Volume', 'Child', 'Child, Preschool', 'Echocardiography, Three-Dimensional', 'Female', 'Humans', 'Image Processing, Computer-Assisted', 'Male', 'Observer Variation', 'Tricuspid Atresia', 'Ventricular Function, Left'] | 10,817,290 | [['M01.060.057'], ['G09.330.380.249'], ['M01.060.406'], ['M01.060.406.448'], ['E01.370.350.130.750.230', 'E01.370.350.400.200', 'E01.370.350.850.220.230', 'E01.370.370.380.220.230'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['E01.354.753', 'N02.421.450.600', 'N05.715.350.150.675', 'N06.850.490.... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Information Science [L]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
[The mutagenicity of a new multicomponent vaccine made from the antigens of Klebsiella pneumoniae, Staphylococcus aureus, Proteus vulgaris and Escherichia coli]. | Inactivated bacterial vaccine, containing K. pneumoniae, S. aureus, P. vulgaris and E. coli antigenic complexes were tested for mutagenicity in the test described by Ames et al. and in vivo, in experiments on mice. In Salmonella typhimurium cells, strain TA-98 and TA-100, the preparation (5-75 mg/ml) did not increase t... | ['Animals', 'Antigens, Bacterial', 'Bacterial Vaccines', 'Bone Marrow', 'Chromosome Aberrations', 'Drug Combinations', 'Escherichia coli', 'Genes, Bacterial', 'Klebsiella pneumoniae', 'Male', 'Mice', 'Mutagenicity Tests', 'Mutagens', 'Mutation', 'Proteus vulgaris', 'Salmonella typhimurium', 'Spermatogonia', 'Staphyloco... | 1,887,711 | [['B01.050'], ['D23.050.161'], ['D20.215.894.135'], ['A15.382.216'], ['C23.550.210', 'G05.365.590.175'], ['D26.310'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['G05.360.340.024.340.364.249', 'G05.360.340.358.024.249', 'G05.360.340.358.207.249'], ['B03.440.450.425.425.600', 'B03.660.250.150.400.590'], ['B... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Regression of mouse tumours and inhibition of metastases following administration of a Semliki Forest virus vector with enhanced expression of IL-12. | The Semliki Forest virus (SFV) vector is an RNA-based suicide expression vector that has been used experimentally for tumour therapy. Recently, a new enhanced vector pSFV10-E has been developed that expresses foreign genes at levels up to 10 times higher than the original vector. Interleukin-12 (IL-12), an immunomodula... | ['Animals', 'Biomarkers, Tumor', 'Breast Neoplasms', 'Cell Line, Tumor', 'Colorectal Neoplasms', 'Combined Modality Therapy', 'Female', 'Gene Expression', 'Genetic Therapy', 'Immunohistochemistry', 'Immunotherapy', 'Interleukin-12', 'Lung Neoplasms', 'Mice', 'Mice, Inbred BALB C', 'Neoplasms, Experimental', 'Neovascula... | 15,944,731 | [['B01.050'], ['D23.101.140'], ['C04.588.180', 'C17.800.090.500'], ['A11.251.210.190', 'A11.251.860.180'], ['C04.588.274.476.411.307', 'C06.301.371.411.307', 'C06.405.249.411.307', 'C06.405.469.158.356', 'C06.405.469.491.307', 'C06.405.469.860.180'], ['E02.186'], ['G05.297'], ['E02.095.301', 'E05.393.420.301'], ['E01.3... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
The mammography screening controversy: who and what is heard in the press? | The objective of this project was to analyze newspaper coverage of the January 2000 meta-analysis by Gotzsche and Olsen, "Is screening for breast cancer with mammography justified?" [Lancet 355 (2000) 129]. A content analysis was performed on a comprehensive set of newspaper clippings from the UK during the 2 weeks fol... | ['Attitude to Health', 'Breast Neoplasms', 'Evidence-Based Medicine', 'Female', 'Humans', 'Mammography', 'Mass Media', 'Mass Screening'] | 12,915,283 | [['F01.100.150', 'N05.300.150'], ['C04.588.180', 'C17.800.090.500'], ['H02.249.750', 'H02.403.200.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.700.500'], ['L01.178.590'], ['E01.370.500', 'E05.318.308.980.438.580', 'N02.421.726.233.443', 'N05.715.360.300.800.438.500', 'N06.850.520.308.980.438.58... | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Diseases [C]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Sexually dimorphic structural abnormalities in major connections of the medial forebrain bundle in alcoholism. | Background: The mesocorticolimbic system is particularly susceptible to the effects of chronic alcoholism. Disruption of this system has been linked to drug seeking and the development of Reward Deficiency Syndrome, a neurobiological framework for describing the development and relapsing patterns of addictions. In this... | ['Adult', 'Aged', 'Aged, 80 and over', 'Alcohol Drinking', 'Alcoholism', 'Anisotropy', 'Basal Forebrain', 'Diffusion Magnetic Resonance Imaging', 'Diffusion Tensor Imaging', 'Female', 'Humans', 'Male', 'Medial Forebrain Bundle', 'Middle Aged', 'Sex Characteristics', 'White Matter'] | 30,035,007 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['F01.145.317.269'], ['C25.775.100.250', 'F03.900.100.350'], ['G01.590.040', 'G02.050'], ['A08.186.211.200.885.287.500.620.374', 'A08.186.211.200.885.287.500.814.695.249', 'A08.186.211.200.885.287.750.374'], ['E01.370.350.825.500.150'], ['E01.370.350.578.7... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Genetic variation in the Toll-like receptor gene cluster (TLR10-TLR1-TLR6) influences disease course in sarcoidosis. | Sarcoidosis is an inflammatory disease of unknown etiology. Various microorganisms have been proposed as etiologic agent suggesting a role for pattern-recognition receptors such as Toll-like receptors (TLRs) in disease pathogenesis, with a special interest in TLR-2. TLR-10, TLR-1, and TLR-6 act as co-receptors for TLR-... | ['Alleles', 'Chronic Disease', 'Cohort Studies', 'Female', 'Gene Frequency', 'Haplotypes', 'Humans', 'Male', 'Multigene Family', 'Polymorphism, Single Nucleotide', 'Sarcoidosis', 'Toll-Like Receptor 1', 'Toll-Like Receptor 10', 'Toll-Like Receptor 2', 'Toll-Like Receptor 6'] | 22,150,367 | [['G05.360.340.024.340.030'], ['C23.550.291.500'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['G05.330'], ['G05.380.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G05.360.340.024.340.645'], ['G05.365.795.598'], ['C15.604.515.827'], ['D12.776.543.750.705.910.500.100'], ['D... | ['Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Adipose-derived stem cells seeded in Pluronic F-127 hydrogel promotes diabetic wound healing. | BACKGROUND: Chronic nonhealing wound is a multifactorial complication of diabetes that results specifically as a consequence of impaired angiogenesis and currently lacks in effective treatments. Although a stem cell-based therapy may provide a novel treatment to augment diabetic wound healing, inferior cell survival at... | ['Adipose Tissue', 'Animals', 'Biomarkers', 'Diabetes Mellitus, Experimental', 'Excipients', 'Hydrogels', 'Ki-67 Antigen', 'Male', 'Neovascularization, Physiologic', 'Poloxamer', 'Rats, Sprague-Dawley', 'Stem Cell Transplantation', 'Transforming Growth Factor beta1', 'Transplantation, Homologous', 'Vascular Endothelial... | 28,595,815 | [['A10.165.114'], ['B01.050'], ['D23.101'], ['C18.452.394.750.074', 'C19.246.240', 'E05.598.500.374'], ['D26.650.700.419', 'D27.720.744.770.419'], ['D20.280.320.375', 'D26.255.165.320.375'], ['D12.776.660.625.500', 'D23.050.290.500', 'D23.101.140.400'], ['G09.330.630'], ['D02.033.455.250.700.682', 'D05.750.741.667', 'D... | ['Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Phase I study of replication-competent adenovirus-mediated double-suicide gene therapy in combination with conventional-dose three-dimensional conformal radiation therapy for the treatment of newly diagnosed, intermediate- to high-risk prostate cancer. | The primary study objective was to determine the safety of intraprostatic administration of a replication-competent, oncolytic adenovirus containing a cytosine deaminase (CD)/herpes simplex virus thymidine kinase (HSV-1 TK) fusion gene concomitant with increasing durations of 5-fluorocytosine and valganciclovir prodrug... | ['Adenoviruses, Human', 'Aged', 'Aged, 80 and over', 'Combined Modality Therapy', 'Cytosine Deaminase', 'DNA, Viral', 'Flucytosine', 'Ganciclovir', 'Gene Expression', 'Genetic Therapy', 'Humans', 'Male', 'Middle Aged', 'Prostatic Neoplasms', 'Recombinant Fusion Proteins', 'Simplexvirus', 'Thymidine Kinase', 'Transgenes... | 14,612,551 | [['B04.280.030.500.350'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E02.186'], ['D08.811.277.151.486.625'], ['D13.444.308.568'], ['D03.383.742.698.421.431'], ['D03.633.100.759.758.399.454.250.300'], ['G05.297'], ['E02.095.301', 'E05.393.420.301'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630... | ['Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Experiences of Caregivers Caring for a Family Member Who Is Using Hemodialysis. | In this qualitative phenomenological study using a purposive sample, six caregivers of patients on hemodialysis were interviewed about their experiences of caring for a family member who uses hemodialysis. Six major themes and 12 subthemes were identified. Perceptions of caregivers are that caregiving is hard work and ... | ['Caregivers', 'Humans', 'Qualitative Research', 'Renal Dialysis'] | 32,083,434 | [['M01.085', 'M01.526.485.200', 'N02.360.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H01.770.644.241.850'], ['E02.870.300', 'E02.912.800']] | ['Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
In vitro Antimicrobial Study for Biological Evaluation of Clerodendrum infortunatum Linn. | OBJECTIVE: To explore a scientific idea, this study was examined for evaluation of antimicrobial potency using root, leaf and stem of ethyl acetate and chloroform extracts of C. infortunatum (Verbenaceae) due to randomly use in traditional medicine to cure common ailments such as intestinal disorder, diarrhea, tubercul... | ['Acetates', 'Anti-Bacterial Agents', 'Antifungal Agents', 'Chloroform', 'Clerodendrum', 'Fluconazole', 'Microbial Sensitivity Tests', 'Patents as Topic', 'Plant Extracts', 'Plant Leaves', 'Plant Roots', 'Plant Stems', 'Tetracycline'] | 26,497,506 | [['D02.241.081.018', 'D10.251.400.045'], ['D27.505.954.122.085'], ['D27.505.954.122.136'], ['D02.455.526.439.224', 'D02.455.526.913.810'], ['B01.650.940.800.575.912.250.583.520.121'], ['D03.383.129.799.450'], ['E01.370.225.875.595', 'E05.200.875.595', 'E05.337.550.400'], ['I01.880.604.583.458.650', 'N03.706.535.518.650... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Setting a patient-centered research agenda for cerebral palsy: a participatory action research initiative. | AIM: To establish a patient-centered research agenda for cerebral palsy (CP).METHOD: We engaged a large cross-section of the extended community of people living with CP and those providing healthcare to people with CP ('the community') in an educational series and collaborative survey platform to establish an initial l... | ['Cerebral Palsy', 'Cross-Sectional Studies', 'Delphi Technique', 'Female', 'Health Personnel', 'Health Services Research', 'Humans', 'Male', 'Patient-Centered Care', 'Residence Characteristics'] | 30,132,826 | [['C10.228.140.140.254'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['L01.906.197'], ['M01.526.485', 'N02.360'], ['H01.770.644.145.360', 'N03.349.380', 'N05.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N04.590.233.727.407'], ['N01.224.791', 'N06.850.505.400.800']] | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Information Science [L]', 'Named Groups [M]', 'Disciplines and Occupations [H]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 |
Weight correction of MoM values: which method? | BACKGROUND: Adjusting maternal serum markers for maternal weight is considered to be a standard practice when screening for pregnancies associated with Down's syndrome. The choice of model for taking maternal weight into account is, however, rarely explicitly evaluated.METHOD: The relationship between the maternal seru... | ['Biomarkers', 'Body Weight', 'Chorionic Gonadotropin', 'Down Syndrome', 'Estriol', 'Female', 'Fetal Diseases', 'Gestational Age', 'Humans', 'Pregnancy', 'Prenatal Diagnosis', 'Risk Assessment', 'alpha-Fetoproteins'] | 16,603,647 | [['D23.101'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['D06.472.699.322.326', 'D06.472.699.649.367', 'D12.644.548.726.367', 'D12.776.780.400'], ['C10.597.606.360.220', 'C16.131.077.327', 'C16.131.260.260', 'C16.320.180.260'], ['D04.210.500.365... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Release of Periplasmic Nucleotidase Induced by Human Antimicrobial Peptide in E. coli Causes Accumulation of the Immunomodulator Adenosine. | Previous work by our group described that human â-defensin-2 induces accumulation of extracellular adenosine (Ado) in E. coli cultures through a non-lytic mechanism causing severe plasmolysis. Here, we investigate the presence of AMP as a direct precursor and the involvement of a bacterial enzyme in the generation of e... | ['Adenosine', 'Escherichia coli', 'Humans', 'Immunomodulation', 'Nucleotidases', 'Periplasm', 'Phosphoric Monoester Hydrolases', 'Solubility', 'beta-Defensins'] | 26,371,472 | [['D03.633.100.759.590.138', 'D13.570.583.138', 'D13.570.800.096'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.095.465', 'G12.535'], ['D08.811.277.352.650.600'], ['A11.284.295.680'], ['D08.811.277.352.650'], ['G02.805'], ['D12.644.050.200.075', 'D12.77... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Heart transplantation treatment for a malignant cardiac granular cell tumor: 33 months of survival. | A malignant granular cell tumor is a high-grade sarcoma with a high rate of metastasis, local recurrence and short survival. We describe a patient who underwent orthotopic heart transplantation due to a metastatic unresectable malignant granular cell tumor. At thirty-three months following this procedure she is alive a... | ['Disease-Free Survival', 'Female', 'Granular Cell Tumor', 'Heart Neoplasms', 'Heart Transplantation', 'Humans', 'Middle Aged', 'Time Factors', 'Treatment Outcome'] | 17,670,739 | [['E01.789.800.190', 'E05.318.740.998.300', 'N04.761.559.590.800.190', 'N05.715.360.575.575.800.190', 'N05.715.360.750.795.300', 'N06.850.520.830.998.300'], ['C04.557.450.590.350'], ['C04.588.894.309', 'C14.280.459'], ['E04.100.376.475', 'E04.928.220.390', 'E04.936.450.475'], ['B01.050.150.900.649.313.988.400.112.400.4... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Analysis of mutations in DNA gyrase and topoisomerase IV of Ureaplasma urealyticum and Ureaplasma parvum serovars resistant to fluoroquinolones. | This study aims to determine the prevalence of fluoroquinolone resistance of Ureaplasma biovars and serovars isolated from urogenital clinical samples and determine the underlying molecular mechanism for quinolone resistance for all resistant isolates. Of 105 samples confirmed as positive for U. urealyticum/U. parvum, ... | ['Anti-Bacterial Agents', 'Bacterial Proteins', 'DNA Gyrase', 'DNA Topoisomerase IV', 'DNA, Bacterial', 'Drug Resistance, Bacterial', 'Fluoroquinolones', 'Humans', 'Mutation', 'Ureaplasma', 'Ureaplasma Infections', 'Ureaplasma urealyticum'] | 27,884,651 | [['D27.505.954.122.085'], ['D12.776.097'], ['D08.811.399.403.741.149', 'D12.776.097.237'], ['D08.811.399.403.741.224', 'D12.776.097.256'], ['D13.444.308.212'], ['G06.099.225', 'G06.225.347', 'G07.690.773.984.269.347'], ['D03.633.100.810.835.322'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G05.365.590'], ['B03.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
An X-linked NDI mutation reveals a requirement for cell surface V2R expression. | Function and biochemical properties of the V2 vasopressin receptor (V2R) mutant R337ter, identified in patients suffering from X-linked recessive nephrogenic diabetes insipidus, were investigated by expression in COS.M6 or HEK293 cells. Binding assays and measurements of adenylyl cyclase activity failed to detect funct... | ['Adenylyl Cyclases', 'Amino Acid Sequence', 'Animals', 'Arginine Vasopressin', 'COS Cells', 'Cell Line', 'Diabetes Insipidus, Nephrogenic', 'Genes, Recessive', 'Humans', 'Molecular Sequence Data', 'Mutation', 'Receptors, Vasopressin', 'Sequence Deletion', 'X Chromosome'] | 9,171,234 | [['D08.811.520.650.200', 'D12.644.360.050', 'D12.776.476.050'], ['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D06.472.699.631.692.781.100', 'D12.644.400.900.100', 'D12.644.456.925.100', 'D12.644.548.691.692.781.100', 'D12.776.631.650.937.100'], ['A11.251.210.172.500', 'A11.329.228.220'], ['A11.251.210'], [... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Gardnerella vaginalis: an unusual case of pyogenic liver abscess. | We present a case of pyogenic liver abscess caused by Gardnerella vaginalis, a previously unreported suppurative complication of infection with this organism. The development of the pylephlebitis originating from endometritis and the possible synergistic interaction of an anaerobic and aerobic organism is reviewed. G. ... | ['Adult', 'Female', 'Gardnerella vaginalis', 'Haemophilus Infections', 'Humans', 'Liver Abscess', 'Suppuration'] | 3,264,109 | [['M01.060.116'], ['B03.510.024.400.800'], ['C01.150.252.400.700.433'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C01.830.025.020.455', 'C06.552.597'], ['C01.830', 'C23.550.470.756']] | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Investigation of activation cross sections of deuteron induced reactions on indium up to 40 MeV for production of a 113 Sn/113m In generator. | (113)Sn (115.09 d) is the parent nuclide of the (113)Sn/(113m)In generator system. (113m)In (99.476 min) is used in diagnostic nuclear medicine and as an Auger-electron emitter is a candidate for internal radiotherapy. Excitation functions of the (nat)In(d,x) (113 mg)Sn, (116 m)In, (ind115m)In, (114m)In, (ind113m)In, (... | ['Deuterium', 'Humans', 'Indium Radioisotopes', 'Nuclear Medicine', 'Tin Radioisotopes'] | 20,800,504 | [['D01.268.406.500', 'D01.362.340.500', 'D01.496.289'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.496.749.460'], ['H02.403.740.500'], ['D01.496.749.910']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Thrombin-activated microglia contribute to death of dopaminergic neurons in rat mesencephalic cultures: dual roles of mitogen-activated protein kinase signaling pathways. | This study evaluated the role of thrombin-activated microglia in the neurodegeneration of mesencephalic cultures. Immunocytochemical and biochemical evidence indicated that in co-cultures consisting of rat cortical microglia and mesencephalic neurons, thrombin led to nonselective loss of mesencephalic neurons. Accompan... | ['Animals', 'Cell Death', 'Cells, Cultured', 'Coculture Techniques', 'Culture Media, Conditioned', 'Cytokines', 'Dopamine', 'Enzyme Inhibitors', 'Gliosis', 'JNK Mitogen-Activated Protein Kinases', 'MAP Kinase Signaling System', 'Mesencephalon', 'Microglia', 'Mitogen-Activated Protein Kinase 3', 'Nerve Degeneration', 'N... | 15,789,435 | [['B01.050'], ['G04.146'], ['A11.251'], ['E05.481.500.374'], ['D27.720.470.305.250', 'E07.206.250'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['D02.092.211.215.406', 'D02.092.311.342', 'D02.455.426.559.389.657.166.175.342'], ['D27.505.519.389'], ['C23.550.369'], ['D08.811.913.696.620.682.700.567.374', 'D1... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Neuronal nicotinic acetylcholine receptors in Drosophila: antibodies against an alpha-like and a non-alpha-subunit recognize the same high-affinity alpha-bungarotoxin binding complex. | ALS and ARD proteins are thought to represent a ligand binding and a structural subunit, respectively, of Drosophila nicotinic acetylcholine receptors (nAChRs). Here, antibodies raised against fusion constructs encompassing specific regions of the ALS and ARD proteins were used to investigate a potential association of... | ['Animals', 'Antibodies', 'Antigen-Antibody Complex', 'Bungarotoxins', 'Cell Membrane', 'Cloning, Molecular', 'Drosophila', 'Electrophoresis, Polyacrylamide Gel', 'Kinetics', 'Macromolecular Substances', 'Models, Structural', 'Neurons', 'Protein Conformation', 'Receptors, Nicotinic', 'Recombinant Fusion Proteins', 'alp... | 1,919,573 | [['B01.050'], ['D12.776.124.486.485.114', 'D12.776.124.790.651.114', 'D12.776.377.715.548.114'], ['D12.776.124.486.485.114.257', 'D12.776.124.790.651.114.257', 'D12.776.377.715.548.114.257', 'D23.050.101'], ['D20.888.850.325.139', 'D23.946.833.850.325.139'], ['A11.284.149'], ['E05.393.220'], ['B01.050.500.131.617.720.5... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Thoracotomy in the octogenarian. | Octogenarians are rarely referred for thoracic operations, presumably owing to the perceived morbidity of thoracotomy and the presumed frailty and limited life span of the 80-year-old patient. To determine if these concerns are valid, we reviewed our operative experience in 50 patients 80 years of age or older (mean ag... | ['Aged', 'Aged, 80 and over', 'Female', 'Humans', 'Lung Diseases', 'Male', 'Preoperative Care', 'Survival Rate', 'Thoracotomy'] | 2,012,413 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C08.381'], ['E02.760.795', 'E04.604.750', 'N02.421.585.795'], ['E05.318.308.985.550.900', 'N01.224.935.698.826', 'N06.850.505.400.975.550.900', 'N06.850.520.308.985.550.900'], ['E04.928.760']] | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Countries where HIV is concentrated among most-at-risk populations get disproportionally lower funding from PEPFAR. | The legislation reauthorizing the President's Emergency Plan for AIDS Relief (PEPFAR) in 2008 recognized the need for HIV/AIDS programs directed to most-at-risk populations, including men who have sex with men and people who inject drugs. To examine whether that goal is being met, we analyzed data from PEPFAR's Operati... | ['Africa South of the Sahara', 'Developing Countries', 'Female', 'HIV Infections', 'Health Expenditures', 'Health Policy', 'Homosexuality, Male', 'Humans', 'International Cooperation', 'Male', 'Risk Factors', 'Sex Workers', 'Substance Abuse, Intravenous', 'United States', 'Vulnerable Populations'] | 22,778,341 | [['Z01.058.290'], ['I01.615.500.300'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['N03.219.151.450', 'N05.300.385'], ['I01.655.500.608.400', 'I01.880.604.825.608.400', 'N03.623.500.608.428'], ['F01.145.802.975.500.600', 'G08.686.867.500.6... | ['Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Diseases [C]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Absence of cross-reacting material in isolated propionyl CoA carboxylase deficiency: nature of residual carboxylating activity. | Fibroblast extracts and fetal liver homogenates from patients with propionic acidemia due to inherited deficiency of propionyl CoA carboxylase (PCC) were analyzed for the presence of immunologically cross-reactive PCC protein. Using several rabbit antisera raised against homogeneous human liver PCC, homogeneous pig hea... | ['Carboxy-Lyases', 'Fetus', 'Fibroblasts', 'Freezing', 'Humans', 'Immune Sera', 'Immunoglobulins', 'Liver', 'Methylmalonyl-CoA Decarboxylase', 'Mutation'] | 6,859,037 | [['D08.811.520.224.125'], ['A16.378'], ['A11.329.228'], ['G01.645.500', 'G01.906.595.272.437', 'G02.734.466'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A12.207.152.846.500', 'D12.776.124.486.485.114.573', 'D12.776.124.790.651.114.573', 'D12.776.377.715.548.114.573', 'D20.215.401'], ['D12.776.124.486.485', 'D1... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of ethidium bromide and nalidixic acid pretreatment on the induction of chromatid aberrations by TEM and maleic hydrazide in Vicia faba main root meristems. | Pretreatment of Vicia faba main root meristems with ethidium bromide (EB) or nalidixic acid (NA) significantly reduced the yield of metaphases with chromatid aberrations induced by maleic hydrazide (MH), i.e., triggered clastogenic adaptation to MH. No such protection occurred when the alkylating agent triethylenemelam... | ['Chromatids', 'Chromosome Aberrations', 'DNA Repair', 'Drug Interactions', 'Ethidium', 'Fabaceae', 'Maleic Hydrazide', 'Nalidixic Acid', 'Plants, Medicinal', 'Pyridazines', 'Triethylenemelamine'] | 3,380,113 | [['A11.284.430.106.279.345.190.160.175', 'G05.360.160.175'], ['C23.550.210', 'G05.365.590.175'], ['G02.111.222', 'G05.219'], ['G07.690.773.968'], ['D03.633.300.633.416'], ['B01.650.940.800.575.912.250.401'], ['D03.383.710.400'], ['D03.633.100.612.500', 'D03.633.100.810.835.830.500'], ['B01.650.560'], ['D03.383.710'], [... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[The effect of stimulation of the substantia nigra on low- and high-threshold startle reflexes in the cat]. | Effects of the substantia nigra (pars compacta) stimulation on two functional types of startle reflexes were studied in chloralose-anesthetized cats. The reflexes were the low-threshold ones evoked by tactile stimuli (T-reflex) and high-threshold ones evoked by intense peripheral nerve stimulation (spino-bulbo-spinal, ... | ['Animals', 'Cats', 'Conditioning, Psychological', 'Neural Inhibition', 'Physical Stimulation', 'Reflex, Startle', 'Sensory Thresholds', 'Substantia Nigra', 'Time Factors'] | 2,601,770 | [['B01.050'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['F02.463.425.179'], ['G07.265.755', 'G11.561.616'], ['E05.723'], ['E01.370.376.550.650.800', 'E01.370.600.550.650.800', 'F02.830.702.807', 'G11.561.731.869'], ['F02.463.593.710'], ['A08.186.211.132.659.413.656'], ['G01.910.857']] | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Kinesitherapy in the treatement of paralysis of plexus brachialis in the newborn]. | In the treatment of this deformity in a newborn infant, the priority is given to physical therapy with additional orthopaedic treatment, such as adduction splints. In our opinion the treatment of such a defect should start as soon as possible, i.e., immediately after birth. This kind of treatment is usually long and pe... | ['Birth Injuries', 'Brachial Plexus Neuropathies', 'Humans', 'Infant, Newborn', 'Physical Therapy Modalities'] | 17,972,828 | [['C16.614.131', 'C26.141'], ['C10.668.829.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['E02.779', 'E02.831.535']] | ['Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Similar treatment success rate after renal transplantation in diabetic and nondiabetic patients due to improved short- and long-term diabetic patient survival. | In the early era of transplantation, it was common practice to exclude diabetic patients since the outcome in such cases was usually poor. At our center in Malm?, Sweden, diabetic nephropathy was never regarded as a contraindication. During the 22-year period from 1972 to 1993, 223 renal allografts were transplanted in... | ['Adult', 'Diabetes Mellitus', 'Diabetic Nephropathies', 'Female', 'Graft Survival', 'Humans', 'Kidney Transplantation', 'Male', 'Middle Aged', 'Time Factors', 'Treatment Outcome'] | 8,914,235 | [['M01.060.116'], ['C18.452.394.750', 'C19.246'], ['C12.777.419.192', 'C13.351.968.419.192', 'C19.246.099.875'], ['G12.875.545.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.870.500', 'E04.936.450.485', 'E04.950.774.400'], ['M01.060.116.630'], ['G01.910.857'], ['E01.789.800', 'N04.761.559.590.800', 'N05.... | ['Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Specialized Functions of Olive FAD2 Gene Family Members Related to Fruit Development and the Abiotic Stress Response. | Three different cDNA sequences, designated OepFAD2-3, OepFAD2-4 and OepFAD2-5, encoding three microsomal oleate desaturases (FAD2) have been isolated from olive (Olea europaea cv. Picual). Sequence analysis and functional expression in yeast of the corresponding cDNAs confirm that they encode microsomal oleate desatura... | ['DNA, Complementary', 'Dehydration', 'Fatty Acid Desaturases', 'Fruit', 'Gene Expression Regulation, Plant', 'Light', 'Linoleic Acid', 'Lipids', 'Olea', 'Phylogeny', 'Seeds', 'Sequence Analysis', 'Stress, Physiological', 'Temperature', 'Yeasts'] | 31,730,170 | [['D13.444.308.497.220', 'D13.444.600.223.500', 'D27.720.470.530.600.223.260'], ['C18.452.950.179', 'C23.550.274'], ['D08.811.682.690.708.392'], ['A18.024.500', 'G07.203.300.562', 'J02.500.562'], ['G05.308.375'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['D10.251.355.310.515.500', '... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 |
Smooth-muscle BMAL1 participates in blood pressure circadian rhythm regulation. | As the central pacemaker, the suprachiasmatic nucleus (SCN) has long been considered the primary regulator of blood pressure circadian rhythm; however, this dogma has been challenged by the discovery that each of the clock genes present in the SCN is also expressed and functions in peripheral tissues. The involvement a... | ['ARNTL Transcription Factors', 'Animals', 'Blood Pressure', 'Circadian Rhythm', 'Enzyme Induction', 'Male', 'Mesenteric Arteries', 'Mice, Knockout', 'Muscle Contraction', 'Muscle Development', 'Muscle, Smooth, Vascular', 'Myosin Light Chains', 'Promoter Regions, Genetic', 'Protein Binding', 'Protein Processing, Post-T... | 25,485,682 | [['D12.644.360.138.049', 'D12.776.260.103.249', 'D12.776.476.156.100', 'D12.776.930.125.249'], ['B01.050'], ['E01.370.600.875.249', 'G09.330.380.076'], ['G07.180.562.190'], ['G05.308.320.200'], ['A07.015.114.565'], ['B01.050.050.136.500.500', 'B01.050.150.900.649.313.992.635.505.500.550.455', 'B01.050.150.900.649.313.9... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A novel mutation in the EXT1 gene identified in a Han Chinese kindred with hereditary multiple exostosis. | Hereditary multiple exostoses (HME) is an autosomal dominant bone disorder characterized by growth of benign multiple exostoses. In our present study, we describe a four-generation Han Chinese kindred with eight members affected by HME. Haplotyping analysis and mutation detection was performed. The results linked the d... | ['Adolescent', 'Adult', 'Aged', 'China', 'Chromosomes, Human, Pair 8', 'Exostoses, Multiple Hereditary', 'Family', 'Female', 'Genetic Testing', 'Haplotypes', 'Heterozygote', 'Humans', 'Male', 'Middle Aged', 'Mutation', 'N-Acetylglucosaminyltransferases', 'Pedigree', 'Young Adult'] | 20,578,942 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['Z01.252.474.164'], ['A11.284.187.520.300.325.340', 'G05.360.162.520.300.325.340'], ['C04.557.450.565.575.610.615.325', 'C04.700.330', 'C05.116.099.708.670.615.325', 'C05.116.540.310.500', 'C16.320.700.330'], ['F01.829.263', 'I01.880.853.150'], ['E01.370.225.562'... | ['Named Groups [M]', 'Geographicals [Z]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Chemicals ... | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Experimental Van Deemter plots of shear-driven liquid chromatographic separations in disposable microchannels. | We present a new stationary phase coating method, yielding a monolayer of densely arrayed porous HPLC beads (d(p)=4 microm) for use in a disposable shear-driven flow LC system. The system is inherently suited for whole-column detection through the small voids between the individual particles of the layer. The chromatog... | ['Chromatography, Liquid', 'Microscopy, Electron, Scanning'] | 12,613,795 | [['E05.196.181.400'], ['E01.370.350.515.402.541', 'E05.595.402.541']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Adam Politzer (1835-1920) and the description of otosclerosis. | In 1893, Adam Politzer was the first to describe otosclerosis as a specific disease fixating the stapes. The aim of this study is to follow Politzer's research to understand how he finally explained the mechanism responsible for the fixation of the stapes. Politzer conducted his preliminary research from 1862 to 1893. ... | ['Ear, Inner', 'History, 19th Century', 'History, 20th Century', 'Humans', 'Ossification, Heterotopic', 'Otolaryngology', 'Otosclerosis', 'Stapes'] | 16,437,001 | [['A09.246.300'], ['K01.400.504.937'], ['K01.400.504.968'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.751'], ['H02.403.810.526'], ['C09.218.768'], ['A09.246.397.247.806']] | ['Anatomy [A]', 'Humanities [K]', 'Organisms [B]', 'Diseases [C]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
[Perception of dyspnea in asthmatics--long-term study]. | The authors investigated the relationship between perception of dyspnoea and some respiratory parameters (vital capacity - FVC, one-second vital capacity - FEV 1) in 43 patients with bronchial asthma. They followed up the changes of this relationship during repeated examinations within 3 - 60 months following the first... | ['Adolescent', 'Adult', 'Aged', 'Asthma', 'Dyspnea', 'Female', 'Forced Expiratory Volume', 'Humans', 'Male', 'Middle Aged', 'Perception', 'Vital Capacity'] | 8,600,651 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['C08.618.326', 'C23.888.852.371'], ['E01.370.386.700.660.230', 'G09.772.650.430'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['F02.463.593'], ['E01.370.386.700.4... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Technical aspects of prolonged scalp expansion. | Tissue expansion offers the reconstructive surgeon a better option than the conventional methods of skin grafts or the transfer for non-hair-bearing, regional or microsurgical flaps for reconstructing large defects that cannot be repaired with adjacent hair-bearing flaps. Aspects of preoperative planning and technical ... | ['Adolescent', 'Adult', 'Female', 'Humans', 'Infant', 'Male', 'Scalp', 'Skin Neoplasms', 'Tissue Expansion'] | 8,166,975 | [['M01.060.057'], ['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['A01.456.810'], ['C04.588.805', 'C17.800.882'], ['E04.680.800']] | ['Named Groups [M]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Information technology strategy: three misconceptions. | The core intent in developing an IT strategy is to ensure that there is a strong and clear relationship between IT investment decisions and the organization's overall strategies, goals, and objectives. In the course of developing an IT strategy, an organization may fall victim to three major misconceptions about IT str... | ['Decision Making, Organizational', 'Diffusion of Innovation', 'Humans', 'Information Systems', 'Medical Informatics', 'Technology', 'United States'] | 17,091,793 | [['N04.452.190'], ['L01.143.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.313.500.750.300'], ['L01.313.500'], ['J01.897'], ['Z01.107.567.875']] | ['Health Care [N]', 'Information Science [L]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 |
Novel genetic loci associated HLA-B*08:01 positive myasthenia gravis. | OBJECTIVE: To identify potential causative markers involved in the development of early-onset myasthenia gravis (EOMG) in the MHC and non-MHC regions that may interact with the HLA-B*08:01 allele.METHODS: We analyzed 583 MG patients and identified 5 patients homozygous for the disease-associated ancestral haplotype 8.1... | ['Adaptor Proteins, Signal Transducing', 'Adolescent', 'Adult', 'Alleles', 'Endopeptidases', 'Female', 'Gene Frequency', 'Genetic Loci', 'Genetic Predisposition to Disease', 'Genotype', 'HLA-B8 Antigen', 'High-Throughput Nucleotide Sequencing', 'Humans', 'Male', 'Middle Aged', 'Myasthenia Gravis', 'Polymorphism, Single... | 29,037,440 | [['D12.644.360.024', 'D12.776.157.057', 'D12.776.476.024'], ['M01.060.057'], ['M01.060.116'], ['G05.360.340.024.340.030'], ['D08.811.277.656.300'], ['G05.330'], ['G05.360.340.024.380'], ['C23.550.291.687.500', 'G05.380.355'], ['G05.380'], ['D12.776.395.550.489.500.080', 'D12.776.543.550.439.500.080', 'D23.050.301.500.1... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Detergent removal during membrane reconstitution. | Efficiency of detergent removal during the course of several different procedures for membrane protein reconstitution was examined. Reconstitution methods studied include ethanol injection-dialysis, detergent dialysis and detergent-gel filtration. In the ethanol injection-dialysis method, approx. 70 molecules of ethano... | ['Chromatography, Gel', 'Deoxycholic Acid', 'Detergents', 'Dialysis', 'Ethanol', 'Glycophorins', 'Liposomes', 'Membrane Proteins', 'Surface-Active Agents'] | 7,407,173 | [['E05.196.181.400.250'], ['D04.210.500.105.225.272', 'D04.210.500.221.430.342'], ['D27.720.877.265', 'J01.516.381'], ['E05.196.353', 'G02.186'], ['D02.033.375'], ['D12.644.233.800.350', 'D12.776.395.700.350'], ['D25.479.517', 'D26.255.260.517', 'J01.637.051.479.517', 'J01.637.087.500.517'], ['D12.776.543'], ['D27.720.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Malignant leiomyomatosis peritonealis disseminata. | Leiomyomatosis peritonealis disseminata is a rare condition characterized by the presence of multiple intraabdominal nodules that consist of benign smooth muscle. We found 42 documented cases in the literature. Malignant degeneration appears to be extremely rare. We describe the second case with proved malignancy. | ['Abdominal Neoplasms', 'Adult', 'Female', 'Humans', 'Leiomyoma', 'Neoplasms, Multiple Primary', 'Peritoneal Neoplasms', 'Uterine Neoplasms'] | 2,386,147 | [['C04.588.033'], ['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.450.590.450'], ['C04.651'], ['C04.588.033.513', 'C04.588.274.780', 'C06.301.780', 'C06.844.620'], ['C04.588.945.418.948', 'C13.351.500.852.762', 'C13.351.937.418.875']] | ['Diseases [C]', 'Named Groups [M]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Heterogeneous Expression and Functional Characterization of Cellulose-Degrading Enzymes from Aspergillus niger for Enzymatic Hydrolysis of Alkali Pretreated Bamboo Biomass. | Enzymatic hydrolysis of cellulosic biomass has caught much attention because of modest reaction conditions and environment friendly conditions. To reduce the cost and to achieve good quantity of cellulases, a heterologous expression system is highly favored. In this study, cellulose-degrading enzymes, GH3 family â-gluc... | ['Alkalies', 'Aspergillus niger', 'Biomass', 'Carbohydrate Metabolism', 'Cellulase', 'Cellulose', 'Cellulose 1,4-beta-Cellobiosidase', 'beta-Glucosidase'] | 26,202,492 | [['D01.045'], ['B01.300.381.081.450'], ['G16.500.275.157.100', 'N06.230.124.100'], ['G02.111.158', 'G03.191'], ['D08.811.277.450.420.200.200'], ['D05.750.078.562.180', 'D09.698.365.180', 'D25.720.099.500', 'J01.637.051.720.099.500'], ['D08.811.277.450.420.200.400'], ['D08.811.277.450.420.200.100']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Target molecules in 3T3-L1 adipocytes differentiation are regulated by maslinic acid, a natural triterpene from Olea europaea. | BACKGROUND: Metabolic syndrome is a set of pathologies among which stand out the obesity, which is related to the lipid droplet accumulation and changes to cellular morphology regulated by several molecules and transcription factors. Maslinic acid (MA) is a natural product with demonstrated pharmacological functions in... | ['3T3-L1 Cells', 'Adipocytes', 'Adipogenesis', 'Animals', 'Calcium', 'Cell Differentiation', 'Cell Survival', 'Fatty Acid-Binding Proteins', 'Glucose', 'Mice', 'Olea', 'PPAR gamma', 'RNA', 'Triglycerides', 'Triterpenes'] | 27,765,349 | [['A11.251.210.100.775.800', 'A11.329.228.100.775.800'], ['A11.329.114'], ['G04.152.149'], ['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['G04.152'], ['G04.346'], ['D12.776.157.170'], ['D09.947.875.359.448'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.650.940.800.575.912.250.583.640.666'],... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Validity and reliability of a quality-of-life instrument: the chronic respiratory disease questionnaire. | A pilot study was done to evaluate criterion-related validity and test-retest reliability of the Chronic Respiratory Disease Questionnaire (CRQ). The CRQ examines how chronic obstructive pulmonary disease (COPD) effects quality of life, and evaluates four dimensions: dyspnea, fatigue, emotional function, and mastery. T... | ['Activities of Daily Living', 'Aged', 'Female', 'Humans', 'Internal-External Control', 'Lung Diseases, Obstructive', 'Male', 'Pilot Projects', 'Quality of Life', 'Reproducibility of Results', 'Surveys and Questionnaires'] | 8,173,519 | [['E02.760.169.063.500.067', 'E02.831.067', 'I03.050', 'N02.421.784.110'], ['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.379'], ['C08.381.495'], ['E05.318.372.750', 'E05.337.737', 'N05.715.360.330.720', 'N06.850.520.450.720'], ['I01.800', 'K01.752.400.750', 'N06.850.505.400.425.837'], ... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Named Groups [M]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Humanities [K]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Case-control and vector studies of nosocomial acquisition of Pseudomonas cepacia in adult patients with cystic fibrosis. | OBJECTIVE: To examine factors associated with nosocomial acquisition of Pseudomonas cepacia in adult patients with cystic fibrosis.DESIGN: A retrospective case-control study of 5 patients with nosocomial acquisition of P cepacia versus 20 matched controls who failed to develop P cepacia infection. Selective handwashing... | ['Adult', 'Air Microbiology', 'Burkholderia cepacia', 'Case-Control Studies', 'Cross Infection', 'Cystic Fibrosis', 'Disease Reservoirs', 'Equipment Contamination', 'Hand Disinfection', 'Hospitals, University', 'Humans', 'Nebulizers and Vaporizers', 'Pseudomonas Infections', 'Retrospective Studies'] | 7,683,031 | [['M01.060.116'], ['H01.158.273.540.274.110', 'N06.850.425.110'], ['B03.660.075.090.688.100.110.500'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['C01.248', 'C23.550.291.875.500'], ['C06.689.202', 'C08.381.187', 'C16.320.190', 'C16.614.213'], ['N06.850.520.203.250'], ['N06.850.540']... | ['Named Groups [M]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Association of reduced zinc status with angiographically severe coronary atherosclerosis: a pilot study. | In vitro studies attribute antiatherogenic and insulin-like properties to zinc (Zn). However, only a few conflicting clinical data exist concerning the relationship between Zn and coronary artery disease (CAD) as well as glycemic indices. We studied 72 patients without prior history of myocardial infarction or revascul... | ['Aged', 'Angina Pectoris', 'Blood Glucose', 'Coronary Angiography', 'Coronary Artery Disease', 'Coronary Stenosis', 'Diabetes Mellitus, Type 2', 'Female', 'Glycated Hemoglobin A', 'Humans', 'Male', 'Middle Aged', 'Pilot Projects', 'Risk Factors', 'Statistics as Topic', 'Zinc'] | 20,529,979 | [['M01.060.116.100'], ['C14.280.647.187', 'C14.907.585.187', 'C23.888.592.612.233.500'], ['D09.947.875.359.448.500'], ['E01.370.350.130.625', 'E01.370.350.700.060.200', 'E01.370.370.050.200', 'E01.370.370.380.200'], ['C14.280.647.250.260', 'C14.907.137.126.339', 'C14.907.585.250.260'], ['C14.280.647.250.285', 'C14.907.... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Synchronous multifocal HPV-related neoplasm involving both the genital tract and the head-and-neck area: a case report of Fanconi anemia. | We report the case of a 32-year-old woman who presented with multiple squamous cell neoplasms synchronously arising in the cervix, vulva, oral cavity and oropharynx. During the period when the patient was treated by radiotherapy, she developed severe radiation mucositis and pancytopenia. Immunofluorescence staining for... | ['Adult', 'Carcinoma, Squamous Cell', 'Fanconi Anemia', 'Female', 'Genital Neoplasms, Female', 'Head and Neck Neoplasms', 'Humans', 'Papillomavirus Infections'] | 19,368,986 | [['M01.060.116'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['C15.378.071.085.080.280', 'C15.378.190.223.500.500.280', 'C16.320.077.280', 'C18.452.284.280'], ['C04.588.945.418', 'C13.351.937.418'], ['C04.588.443'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C01.925.256.650', 'C01.925.928.725']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Effects of neurotoxic and neuroprotective agents on peripheral nerve regeneration assayed by time-lapse imaging in vivo. | A direct histological assay of axonal regeneration would have many advantages over currently available behavioral, electrophysiological, and radiometric assays. We show that peripheral sensory axons marked with the yellow fluorescent protein in transgenic mice can be viewed transcutaneously in superficial nerves. Degen... | ['Animals', 'Axons', 'Axotomy', 'Bacterial Proteins', 'Green Fluorescent Proteins', 'Kinetics', 'Luminescent Proteins', 'Mice', 'Mice, Transgenic', 'Microscopy, Fluorescence', 'Nerve Degeneration', 'Nerve Regeneration', 'Neuroprotective Agents', 'Neurotoxins', 'Peripheral Nerves', 'Tacrolimus', 'Vincristine'] | 14,673,013 | [['B01.050'], ['A08.675.542.145', 'A11.284.180.075', 'A11.671.137', 'A11.671.501.145'], ['E04.525.210.158'], ['D12.776.097'], ['D12.776.532.265'], ['G01.374.661', 'G02.111.490'], ['D12.776.532'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.136.500', 'B01.050.150.900.649.313.992.635.505.500.800'], ['E01.3... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Uniform isotope labeling of a eukaryotic seven-transmembrane helical protein in yeast enables high-resolution solid-state NMR studies in the lipid environment. | Overexpression of isotope-labeled multi-spanning eukaryotic membrane proteins for structural NMR studies is often challenging. On the one hand, difficulties with achieving proper folding, membrane insertion, and native-like post-translational modifications frequently disqualify bacterial expression systems. On the othe... | ['Fungal Proteins', 'Isotope Labeling', 'Lipids', 'Membrane Proteins', 'Nuclear Magnetic Resonance, Biomolecular', 'Yeasts'] | 21,246,256 | [['D12.776.354'], ['E05.522'], ['D10'], ['D12.776.543'], ['E05.196.867.519.550'], ['B01.300.930']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Self-rated health and risk factors for metabolic syndrome among middle-aged men. | OBJECTIVES: To examine lifestyle and clinical risk factors for metabolic syndrome (MBO) and compare their significance between levels of self-rated health among middle-aged men.DESIGN: A cross-sectional baseline study.SAMPLE: 273 men, aged 40, living in Helsinki, Finland.METHODS: Postal questionnaires and health examin... | ['Cross-Sectional Studies', 'Finland', 'Health Knowledge, Attitudes, Practice', 'Health Status', 'Humans', 'Life Style', 'Male', 'Metabolic Syndrome', 'Middle Aged', 'Public Health Nursing', 'Risk Factors'] | 16,371,072 | [['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['Z01.542.816.186'], ['F01.100.150.500', 'N05.300.150.410'], ['I01.240.425', 'N01.224.425', 'N06.850.505.400.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.458'], ['C18.452.394.968.500.570', 'C18.452.625'], ['M01.060.116.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Diseases [C]', 'Named Groups [M]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Tissue factor expression correlates with disease-specific survival in patients with node-negative muscle-invasive bladder cancer. | Tissue factor (TF), a transmembrane glycoprotein responsible for initiating the extrinsic pathway of blood coagulation plays a key role in cancer growth, metastasis and angiogenesis. Various studies have demonstrated the prognostic potential of TF expression in several cancers. However, its role in bladder cancer is un... | ['Aged', 'Analysis of Variance', 'Biomarkers, Tumor', 'Carcinoma, Transitional Cell', 'Cystectomy', 'Disease-Free Survival', 'Female', 'Follow-Up Studies', 'Humans', 'Immunohistochemistry', 'Kaplan-Meier Estimate', 'Lymphatic Metastasis', 'Male', 'Middle Aged', 'Neoplasm Invasiveness', 'Neoplasms, Muscle Tissue', 'Pred... | 18,058,798 | [['M01.060.116.100'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['D23.101.140'], ['C04.557.470.200.430'], ['E04.950.774.150'], ['E01.789.800.190', 'E05.318.740.998.300', 'N04.761.559.590.800.190', 'N05.715.360.575.575.800.190', 'N05.715.360.750.795.300', 'N06.850.520.830.998.300'], ['E05.318.37... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Serial observations of circulating immune complexes in patients with acute schistosomiasis. | To define further the role of circulating immune complexes in acute schistosomiasis, serial determinations of [125I]Clq binding activity (ClqBA) in 15 patients with this disease were made before and after treatment with niridazole. Levels of ClqBA were elevated in 13 of these patients and in general rose early in the c... | ['Acute Disease', 'Adolescent', 'Adult', 'Antigen-Antibody Complex', 'Child', 'Complement C1', 'Female', 'Humans', 'Immunoglobulin G', 'Immunoglobulin M', 'Male', 'Parasite Egg Count', 'Schistosoma mansoni', 'Schistosomiasis', 'Time Factors'] | 7,462,683 | [['C23.550.291.125'], ['M01.060.057'], ['M01.060.116'], ['D12.776.124.486.485.114.257', 'D12.776.124.790.651.114.257', 'D12.776.377.715.548.114.257', 'D23.050.101'], ['M01.060.406'], ['D12.776.124.486.274.050'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.124.486.485.114.619.393', 'D12.776.124.790.651.11... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Unprotected left main intervention for surgery-ineligible patients with coronary artery disease-Usefulness of micro-CT images for stent. | BACKGROUND: Percutaneous coronary intervention (PCI) for unprotected left main truncus (LMT) lesions is controversial. Inoperable status with advanced age, renal dysfunction, frailty, or patient request may require an unprotected left main PCI. PCI for LMT is not recommended in the typical clinical situation; however, ... | ['Aged', 'Coronary Angiography', 'Coronary Artery Disease', 'Coronary Vessels', 'Drug-Eluting Stents', 'Female', 'Humans', 'Immunosuppressive Agents', 'Japan', 'Male', 'Percutaneous Coronary Intervention', 'Retrospective Studies', 'Sirolimus', 'Treatment Outcome', 'X-Ray Microtomography'] | 27,404,711 | [['M01.060.116.100'], ['E01.370.350.130.625', 'E01.370.350.700.060.200', 'E01.370.370.050.200', 'E01.370.370.380.200'], ['C14.280.647.250.260', 'C14.907.137.126.339', 'C14.907.585.250.260'], ['A07.015.114.269', 'A07.015.908.194'], ['E07.695.750.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.477.6... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
[The arterial blood supply of the tibial and practical consequences]. | In the periosteum of the human tibia, the arterial blood supply shows a general sectorial angioarchitecture. There are 4 segments: proximal and distal 1/5, proximal and distal diaphysis. The proximal 1/5 of the tibial periosteum is supplied with blood by the aa. recurrentes tibiales anterior et posterior and the aa. in... | ['Aged', 'Aged, 80 and over', 'Arteries', 'External Fixators', 'Female', 'Fracture Fixation, Intramedullary', 'Humans', 'Male', 'Middle Aged', 'Pseudarthrosis', 'Regional Blood Flow', 'Tibia', 'Tibial Fractures', 'Wound Healing'] | 1,508,012 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['A07.015.114'], ['E07.858.442.660.430', 'E07.858.690.725.430'], ['E04.555.300.300.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C26.404.468.627'], ['G09.330.100.780'], ['A02.835.232.043.650.883'], ['C26.404.875', 'C26.558.857'], ['G16.762.... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Sources of cholinergic input to the inferior colliculus. | We combined retrograde tracing with immunohistochemistry for choline acetyltransferase to identify the source of cholinergic input to the inferior colliculus (IC) in guinea pigs. Injection of a retrograde tracer into one IC labeled cells in many brainstem nuclei. Retrogradely-labeled cells that were also immunoreactive... | ['Acetylcholine', 'Animals', 'Choline O-Acetyltransferase', 'Female', 'Guinea Pigs', 'Immunohistochemistry', 'Inferior Colliculi', 'Male', 'Neural Pathways', 'Pedunculopontine Tegmental Nucleus', 'Photomicrography', 'Tegmentum Mesencephali'] | 19,281,878 | [['D02.092.211.111'], ['B01.050'], ['D08.811.913.050.134.180'], ['B01.050.150.900.649.313.992.550'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512', 'H01.158.201.344.512', 'H01.158.201.486.512', 'H01.181.122.573.512', 'H01.18... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Neuronal fiber bundle lengths in healthy adult carriers of the ApoE4 allele: a quantitative tractography DTI study. | The epsilon 4 (e4) isoform of apolipoprotein E (ApoE) is a known genetic risk factor for suboptimal brain health. Morphometry studies of brains with Alzheimer's disease have reported significant alterations in temporal lobe brain structure of e4 carriers, yet it remains unclear if the presence of an e4 allele is associ... | ['Aged', 'Aged, 80 and over', 'Apolipoprotein E4', 'Diffusion Tensor Imaging', 'Female', 'Heterozygote', 'Humans', 'Male', 'Middle Aged', 'Nerve Fibers, Myelinated', 'Reference Values', 'Reproducibility of Results', 'Sensitivity and Specificity'] | 23,475,756 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['D10.532.091.500.750', 'D12.776.070.400.500.750', 'D12.776.521.120.500.750'], ['E01.370.350.578.750', 'E01.370.350.825.500.150.500', 'E01.370.376.537.500', 'E05.629.750'], ['G05.380.383'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['A08.675.542... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Patient-specific recovery patterns over time measured by dependence in activities of daily living after stroke and post-stroke care: the South London Stroke Register (SLSR). | BACKGROUND AND PURPOSE: Data on patient-specific recovery after stroke are lacking and the effects of complex healthcare interventions on the course of recovery were not reported. To quantify the recovery pattern up to 1 year post-stroke and assess effects of evidence-based treatments on the patient-specific course of ... | ['Activities of Daily Living', 'Adult', 'Aged', 'Aged, 80 and over', 'Cohort Studies', 'Disability Evaluation', 'Female', 'Humans', 'London', 'Male', 'Middle Aged', 'Models, Statistical', 'Multivariate Analysis', 'Recovery of Function', 'Registries', 'Stroke', 'Time Factors', 'Treatment Outcome', 'Young Adult'] | 19,682,061 | [['E02.760.169.063.500.067', 'E02.831.067', 'I03.050', 'N02.421.784.110'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E01.370.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.433.553', 'Z01.542.363.300.553'... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Named Groups [M]', 'Organisms [B]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Trp574 substitution in the acetolactate synthase of Sinapis arvensis confers cross-resistance to tribenuron and imazamox. | Rate-response experiments with nine putative resistant wild mustard (Sinapis arvensis) populations from Greece showed cross-resistance to tribenuron and imazamox. The calculated GR50 values [herbicide rate (gaiha-1) required for 50% reduction of fresh weight] of the nine resistant (R) populations ranged from 51.8 to 55... | ['Acetolactate Synthase', 'Amino Acid Substitution', 'Arylsulfonates', 'Herbicide Resistance', 'Herbicides', 'Imidazoles', 'Mutation, Missense', 'Plant Proteins', 'Sinapis', 'Tryptophan'] | 29,107,252 | [['D08.811.913.200.324', 'D12.776.331.049'], ['E05.393.420.601.035', 'G05.558.109'], ['D02.886.645.600.080.050'], ['G07.690.773.984.443'], ['D27.720.031.700.366', 'D27.888.723.366'], ['D03.383.129.308'], ['G05.365.590.650'], ['D12.776.765'], ['B01.650.940.800.575.912.250.157.811'], ['D12.125.072.050.850', 'D12.125.142.... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Degradation of intracellular proteins at different stages of growth of Saccharomyces cerevisiae]. | The rate of degradation of intracellular proteins at different growth stages of Saccharomyces cerevisiae yeast was determined. It has been demonstrated that the rate of degradation of intracellular proteins increases 2--3-fold at the late exponential phase. The increase was accompanied by corresponding changes in the a... | ['Carbon Radioisotopes', 'Culture Techniques', 'Electrophoresis, Paper', 'Endopeptidases', 'Fungal Proteins', 'Isotope Labeling', 'Leucine', 'Pepstatins', 'Phenylmethylsulfonyl Fluoride', 'Protease Inhibitors', 'Saccharomyces cerevisiae'] | 800,346 | [['D01.268.150.075.328', 'D01.496.123.328', 'D01.496.749.154'], ['E05.481.500'], ['E05.196.401.319', 'E05.301.300.236'], ['D08.811.277.656.300'], ['D12.776.354'], ['E05.522'], ['D12.125.070.637', 'D12.125.142.441'], ['D12.644.456.724'], ['D02.886.590.625'], ['D27.505.519.389.745'], ['B01.300.107.795.785.800', 'B01.300.... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The Surrey County Lunatic Asylum (Springfield). Early years in the development of an institution. | In the mid-19th century, the Commissioners in Lunacy continued the direction of the earlier reform movements, but depended upon local magistrates for the execution of their ideas. The early development of a single county asylum is described from its beginnings, as are some of the personalities involved. | ['History, 19th Century', 'Hospitals, Psychiatric', 'Humans', 'Mental Disorders', 'United Kingdom'] | 1,888,981 | [['K01.400.504.937'], ['N02.278.421.556.508'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F03'], ['Z01.542.363']] | ['Humanities [K]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Inverse analysis to estimate site-specific parameters of a mathematical model for simulating pesticide dissipations in paddy test systems. | BACKGROUND: In Japan, while experimental data for the dissipation behavior of paddy pesticides under a standardized test system are available, the application of a mathematical model is limited. This paper proposes a new model calibration procedure for inversely deriving the model parameters from the experimental data.... | ['Calibration', 'Cold Temperature', 'Herbicides', 'Models, Theoretical', 'Soil', 'Uncertainty'] | 30,471,196 | [['E05.978.155'], ['G01.906.595.272', 'G16.500.275.063.725.710.300', 'G16.500.750.775.710.300', 'N06.230.300.100.725.154', 'N06.230.300.100.725.710.300'], ['D27.720.031.700.366', 'D27.888.723.366'], ['E05.599'], ['D20.721', 'G01.311.820', 'G16.500.275.815', 'N06.230.600'], ['E05.318.740.600.900', 'F02.463.785.373.820',... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]'] | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Comparison of FAIR technique with different inversion times and post contrast dynamic perfusion MRI in chronic occlusive cerebrovascular disease. | The purpose of this study was to examine the signal change occurring with different inversion times (TIs) of the flow-sensitive alternating inversion recovery (FAIR) technique and to compare with the perfusion image obtained with Gd-DTPA injection. The subjects were 11 patients with unilateral occlusive cerebrovascular... | ['Brain', 'Cerebrovascular Circulation', 'Cerebrovascular Disorders', 'Contrast Media', 'Female', 'Gadolinium DTPA', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Perfusion'] | 14,559,333 | [['A08.186.211'], ['G09.330.100.159'], ['C10.228.140.300', 'C14.907.253'], ['D27.505.259.500', 'D27.720.259'], ['D02.092.782.590.401', 'D02.241.081.018.639.400', 'D02.257.141'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['M01.060.116.630'], ['E05.680']] | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Identity-by-descent filtering of exome sequence data identifies PIGV mutations in hyperphosphatasia mental retardation syndrome. | Hyperphosphatasia mental retardation (HPMR) syndrome is an autosomal recessive form of mental retardation with distinct facial features and elevated serum alkaline phosphatase. We performed whole-exome sequencing in three siblings of a nonconsanguineous union with HPMR and performed computational inference of regions i... | ['Adolescent', 'Animals', 'CHO Cells', 'Child, Preschool', 'Cricetinae', 'Cricetulus', 'Databases, Genetic', 'Exons', 'Family Health', 'Female', 'Genetic Predisposition to Disease', 'Glycosylphosphatidylinositols', 'Humans', 'Hyperphosphatemia', 'Infant', 'Intellectual Disability', 'Male', 'Mannosyltransferases', 'Muta... | 20,802,478 | [['M01.060.057'], ['B01.050'], ['A11.251.210.200', 'A11.436.155'], ['M01.060.406.448'], ['B01.050.150.900.649.313.992.635.075.250'], ['B01.050.150.900.649.313.992.635.075.250.250'], ['L01.313.500.750.300.188.400.325', 'L01.470.750.750.325'], ['G05.360.340.024.340.137.232'], ['N01.400.300'], ['C23.550.291.687.500', 'G05... | ['Named Groups [M]', 'Organisms [B]', 'Anatomy [A]', 'Information Science [L]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Use of complementary and alternative medicine among adults with epilepsy in a university epilepsy clinic in Poland. | INTRODUCTION: The use of complementary and alternative medicine (CAM) is becoming increasingly prevalent both in general population and patients with chronic diseases. The aim of the study was to determine the prevalence, reasons, and factors influencing the use of CAM in Polish patients with epilepsy (PWE).MATERIAL AN... | ['Adolescent', 'Adult', 'Age Factors', 'Aged', 'Anticonvulsants', 'Complementary Therapies', 'Cross-Sectional Studies', 'Educational Status', 'Epilepsy', 'Female', 'Humans', 'Logistic Models', 'Male', 'Middle Aged', 'Poland', 'Prospective Studies', 'Risk Factors', 'Young Adult'] | 31,299,531 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['D27.505.954.427.080'], ['E02.190'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['N01.824.196'], ['C10.228.140.490'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.52... | ['Named Groups [M]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Pseudomonas sabulinigri sp. nov., isolated from black beach sand. | A novel Gram-negative, aerobic, motile, short rod-shaped bacterium, designated J64T, was isolated from black sand collected from Soesoggak, Jeju Island, Korea. Cells grew at 4-37 degrees C, at pH 5.5-10.0 and with 0-10 % NaCl. The strain was found to be oxidase- and catalase-positive. Phylogenetic analyses showed that ... | ['Bacterial Typing Techniques', 'DNA, Bacterial', 'DNA, Ribosomal', 'Genes, rRNA', 'Geologic Sediments', 'Korea', 'Nucleic Acid Hybridization', 'Phenotype', 'Phylogeny', 'Pseudomonas', 'RNA, Ribosomal, 16S', 'Seawater', 'Sequence Analysis, DNA', 'Silicon Dioxide', 'Species Specificity'] | 19,126,720 | [['E01.370.225.875.150.125', 'E05.200.875.150.125'], ['D13.444.308.212'], ['D13.444.308.475'], ['G05.360.340.024.340.645.750'], ['G01.311.330', 'G16.500.320'], ['Z01.252.474.557', 'Z01.586.407'], ['E05.393.661', 'G02.111.611'], ['G05.695'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['B03.440.400.425.625.625', 'B03.660... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Information Science [L]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 |
Thickness identification of two-dimensional materials by optical imaging. | Two-dimensional materials, e.g. graphene and molybdenum disulfide (MoS(2)), have attracted great interest in recent years. Identification of the thickness of two-dimensional materials will improve our understanding of their thickness-dependent properties, and also help with scientific research and applications. In this... | ['Disulfides', 'Graphite', 'Materials Testing', 'Molybdenum', 'Nephelometry and Turbidimetry', 'Refractometry'] | 23,154,446 | [['D01.248.497.158.874.390', 'D01.875.350.850.150', 'D02.886.520.150'], ['D01.268.150.300', 'D01.578.300'], ['E05.570'], ['D01.268.556.555', 'D01.268.956.500', 'D01.552.544.555'], ['E05.196.712.650'], ['E05.196.808', 'H01.671.617.755']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Protective effect of O-phenanthroline against mechlorethamine toxicity in the rat liver slice system and in the guinea pig skin. | The effect of O-phenanthroline (OP) on mechlorethamine hydrochloride (HN2) toxicity was studied in in vitro and in vivo experiments. Incubation of HN2 with the in vitro rat liver slice system resulted in leakage of alanine aminotransferase (ALT) in a time-dependent manner. Exposure of the slices to HN2 for 4 h caused 7... | ['Animals', 'Female', 'Guinea Pigs', 'In Vitro Techniques', 'Iron Chelating Agents', 'Liver', 'Male', 'Mechlorethamine', 'Phenanthrolines', 'Rats', 'Rats, Inbred Strains', 'Skin'] | 1,747,067 | [['B01.050'], ['B01.050.150.900.649.313.992.550'], ['E05.481'], ['D27.505.519.914.500.410', 'D27.720.832.500.410'], ['A03.620'], ['D02.455.526.728.650.529'], ['D03.633.300.669'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760', 'B01.050.150.900.649.313.992.635.505.700.400'], ['A17.815']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Hemin as electrochemically regenerable co-reaction accelerator for construction of an ultrasensitive PTCA-based electrochemiluminescent aptasensor. | In this work, hemin was firstly used as electrochemically regenerable co-reaction accelerator for signal amplification to develop an ultrasensitive aptasensor for Aflatoxin M1 (AFM1) detection. Initially, the perylenetetracarboxylic acid (PTCA) was directly employed as luminophore to construct the ECL sensing nano-plat... | ['Aflatoxin M1', 'Animals', 'Aptamers, Nucleotide', 'Biosensing Techniques', 'Electrochemical Techniques', 'Food Contamination', 'Gold', 'Hemin', 'Luminescent Agents', 'Luminescent Measurements', 'Metal Nanoparticles', 'Milk', 'Perylene'] | 28,965,054 | [['D03.383.663.283.119.100', 'D03.633.100.150.119.100', 'D23.946.587.142.100'], ['B01.050'], ['D13.695.578.424.224'], ['E05.601.043'], ['E05.301'], ['J01.576.423.850.730.500.249', 'N06.850.460.400', 'N06.850.601.500.249'], ['D01.268.556.322', 'D01.268.956.186', 'D01.552.544.322'], ['D03.383.129.578.840.500.640.587.462'... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Impact of prior lamivudine use on the antiviral efficacy and development of resistance to entecavir in chronic hepatitis B patients. | BACKGROUND/AIMS: To determine the efficacies of entecavir (ETV) in nucleos(t)ide analogue (NA)-na?ve chronic hepatitis B (CHB) patients and in those with prior lamivudine (LAM) use who did not develop resistance.METHODS: We retrospectively enrolled 337 patients with CHB who were treated with ETV (0.5 mg daily) for at l... | ['Adolescent', 'Adult', 'Aged', 'Antiviral Agents', 'DNA, Viral', 'Drug Resistance, Viral', 'Female', 'Genotype', 'Guanine', 'Hepatitis B virus', 'Hepatitis B, Chronic', 'Humans', 'Lamivudine', 'Male', 'Middle Aged', 'Remission Induction', 'Retrospective Studies', 'Young Adult'] | 26,157,750 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.122.388'], ['D13.444.308.568'], ['G06.225.420', 'G06.920.225', 'G07.690.773.984.269.420'], ['G05.380'], ['D03.633.100.759.758.399.454'], ['B04.280.375.650.425', 'B04.450.390.650.425'], ['C01.221.250.500.100', 'C01.925.256.430.400.100', 'C01.925.440.4... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Lobar dysmorphism of the kidney. | We report a case of a 38-year-old woman with lobar dysmorphism of the kidney. Lobar dysmorphism is a pathology classified under renal pseudotumor, which has received little attention. It is presumed that these cases will increase in number with advances in imaging diagnosis. Dynamic CT scan is useful for the diagnosis ... | ['Adult', 'Female', 'Granuloma, Plasma Cell', 'Humans', 'Kidney Diseases', 'Tomography, X-Ray Computed', 'Ultrasonography'] | 8,536,141 | [['M01.060.116'], ['C23.550.382.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.777.419', 'C13.351.968.419'], ['E01.370.350.350.810', 'E01.370.350.600.350.700.810', 'E01.370.350.700.700.810', 'E01.370.350.700.810.810', 'E01.370.350.825.810.810'], ['E01.370.350.850']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
CIRM and UKRMP: Different Ways to Invest in Regenerative Medicine. | The California Institute for Regenerative Medicine (CIRM) and the UK Regenerative Medicine Platform (UKRMP) have similar objectives, but their histories, funding mechanisms, and governance could hardly be more different. Here, we compare the two programs and explore their impact in translating stem cell research into c... | ['California', 'Cooperative Behavior', 'Investments', 'Regenerative Medicine', 'Stem Cell Research', 'Translational Medical Research', 'United Kingdom'] | 27,392,224 | [['Z01.107.567.875.580.200', 'Z01.107.567.875.760.200'], ['F01.145.813.115'], ['N03.219.702'], ['H02.403.750'], ['E05.242.950', 'H01.770.644.145.512'], ['H01.770.644.145.675'], ['Z01.542.363']] | ['Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
PD-1 Blockers. | Nivolumab and pembrolizumab are monoclonal antibodies that block the programmed death-1 receptor (PD-1, CD279), resulting in dis-inhibition of tumor-specific immune responses. Both are recently approved for use in the treatment of metastatic melanoma, and nivolumab as well for non-small cell lung cancer. | ['Antibodies, Monoclonal', 'Antibodies, Monoclonal, Humanized', 'Antineoplastic Agents', 'Carcinoma, Non-Small-Cell Lung', 'Clinical Trials as Topic', 'Humans', 'Lung Neoplasms', 'Melanoma', 'Nivolumab', 'Programmed Cell Death 1 Receptor', 'Skin Neoplasms'] | 26,317,459 | [['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D12.776.124.486.485.114.224.060', 'D12.776.124.790.651.114.224.060', 'D12.776.377.715.548.114.224.200'], ['D27.505.954.248'], ['C04.588.894.797.520.109.220.249', 'C08.381.540.140.500', 'C08.785.520.100.220.500'], ['E05.318... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
The action of bradykinin and oxytocin on the isolated whole uterus and myometrium of the rat in oestrus. | 1. A technique is described for obtaining a myometrial preparation devoid of endometrium, from the uterus of the rat in oestrus. 2. Acetylcholine and prostaglandin F2alpha (PGF2alpha) produced concentration-effect curves with the same maximal tensions and slope on the whole uterus and myometrial preparations. Concentra... | ['Acetylcholine', 'Animals', 'Bradykinin', 'Drug Synergism', 'Estrus', 'Female', 'In Vitro Techniques', 'Myometrium', 'Oxytocin', 'Polyphloretin Phosphate', 'Pregnancy', 'Prostaglandins F', 'Rats', 'Uterine Contraction', 'Uterus'] | 568,012 | [['D02.092.211.111'], ['B01.050'], ['D12.644.276.812.169', 'D12.644.400.090', 'D12.644.456.193', 'D12.776.467.812.169', 'D12.776.631.650.090', 'D23.469.050.375.110', 'D23.529.812.169'], ['G07.690.773.968.477'], ['G08.686.195.500'], ['E05.481'], ['A02.633.570.500', 'A05.360.319.679.690', 'A10.690.467.500'], ['D06.472.69... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
[The effect of oxidized low density lipoproteins on ADP-induced platelet aggregation in plasma]. | The investigation of the effect of oxidized lipoproteins on platelet activity is important for the understanding of the plague formation under atherosclerosis. In the present work, we examined the influence of low density lipoproteins (LDL) on ADP-induced platelet aggregation in the platelet rich plasma. In was demonst... | ['Adenosine Diphosphate', 'Blood Platelets', 'Cholesterol', 'Drug Interactions', 'Humans', 'Lipoproteins, LDL', 'Phospholipids', 'Platelet Aggregation'] | 9,575,612 | [['D03.633.100.759.646.138.124', 'D13.695.667.138.124', 'D13.695.827.068.124'], ['A11.118.188', 'A15.145.229.188'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['G07.690.773.968'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D10.532.515', 'D12.776.521.550'], ['D10.570.755'], ['G09.... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Fluorescing cells in sputum after parenteral HpD. | Cells exfoliated into sputum were examined for fluorescence after the intravenous injection of HpD. Malignant and non-malignant cells were seen to fluoresce up to 9 days post injection of HpD. Not all exfoliated squamous cell cancer cells or non-malignant cells fluoresced. Implications are discussed relative to imaging... | ['Bronchial Neoplasms', 'Bronchoscopy', 'Carcinoma, Squamous Cell', 'Hematoporphyrin Derivative', 'Hematoporphyrins', 'Humans', 'Injections, Intravenous', 'Sputum'] | 6,241,694 | [['C04.588.894.797.520.109', 'C08.127.265', 'C08.785.520.100'], ['E01.370.386.105', 'E01.370.388.250.100', 'E04.502.250.100', 'E04.928.600.080'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['D03.383.129.578.840.500.462.400', 'D03.633.400.909.500.462.400', 'D04.345.783.500.462.400', 'D23.767.727.462.400'], ['D03.38... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Safety and Tolerability of Intravenous Valproic Acid in Healthy Subjects: A Phase I Dose-Escalation Trial. | BACKGROUND: Valproic acid, a histone deacetylase inhibitor, has beneficial effects in the setting of cancer, neurologic diseases, and traumatic injuries. In animal models of traumatic injury, a single dose of valproic acid has been shown to reduce mortality. The purpose of this trial was to determine the maximum tolera... | ['Administration, Intravenous', 'Adolescent', 'Adult', 'Dose-Response Relationship, Drug', 'Double-Blind Method', 'Female', 'Histone Deacetylase Inhibitors', 'Humans', 'Male', 'Maximum Tolerated Dose', 'Middle Aged', 'Models, Biological', 'Valproic Acid', 'Young Adult'] | 28,497,259 | [['E02.319.267.082'], ['M01.060.057'], ['M01.060.116'], ['G07.690.773.875', 'G07.690.936.500'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['D27.505.519.389.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.940.481', 'G07.690.936.625'], ['M01.060.116.630'], ['E05.5... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A novel stable isotope tracer method to measure muscle protein fractional breakdown rate during a physiological non-steady-state condition. | The measurement of the fractional breakdown rate (FBR) of muscle proteins during physiological non-steady state of amino acids (AAs) presents some challenges. Therefore, the goal of the present experiment was to modify the bolus stable isotope tracer injection approach to determine both fractional synthesis rate (FSR) ... | ['Algorithms', 'Amino Acids', 'Animals', 'Biological Transport', 'Carbon Isotopes', 'Extremities', 'Injections, Intravenous', 'Kinetics', 'Male', 'Models, Biological', 'Muscle Proteins', 'Muscle, Skeletal', 'Nitrogen Isotopes', 'Phenylalanine', 'Protein Biosynthesis', 'Protein Stability', 'Proteolysis', 'Rabbits', 'Thr... | 23,321,475 | [['G17.035', 'L01.224.050'], ['D12.125'], ['B01.050'], ['G03.143'], ['D01.268.150.075', 'D01.496.123'], ['A01.378'], ['E02.319.267.082.750', 'E02.319.267.530.540'], ['G01.374.661', 'G02.111.490'], ['E05.599.395'], ['D12.776.210.500'], ['A02.633.567', 'A10.690.552.500'], ['D01.268.604.500', 'D01.362.625.500', 'D01.496.5... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Alternatives to linear analysis of energy balance data from lactating dairy cows. | The current energy requirements system used in the United Kingdom for lactating dairy cows utilizes key parameters such as metabolizable energy intake (MEI) at maintenance (MEm), the efficiency of utilization of MEI for 1) maintenance, 2) milk production (kl), 3) growth (kg), and the efficiency of utilization of body s... | ['Animal Nutritional Physiological Phenomena', 'Animals', 'Bayes Theorem', 'Calorimetry', 'Cattle', 'Diet', 'Energy Intake', 'Energy Metabolism', 'Female', 'Lactation', 'Linear Models', 'Mathematics', 'Nutritional Requirements'] | 14,507,026 | [['G07.203.650.161'], ['B01.050'], ['E05.318.740.600.200', 'N05.715.360.750.625.150', 'N06.850.520.830.600.200'], ['E05.196.131'], ['B01.050.150.900.649.313.500.380.271'], ['G07.203.650.240'], ['G07.203.650.240.340'], ['G03.295'], ['G08.686.523', 'G08.686.702.500'], ['E05.318.740.500.500', 'E05.318.740.750.425', 'E05.5... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Ethnic variation in CYP2A6*7, CYP2A6*8 and CYP2A6*10 as assessed with a novel haplotyping method. | Cytochrome P450 2A6 is the main human nicotine metabolizing enzyme coded for by a highly polymorphic gene, CYP2A6. CYP2A6*7, CYP2A6*8 and CYP2A6*10 are variant alleles common to Asian ethnicities. The CYP2A6*7 and CYP2A6*8 alleles each contain a non-synonymous single nucleotide polymorphism (SNP) 6558T>C and 6600G>T, r... | ['Africa', 'African Continental Ancestry Group', 'Alleles', 'Aryl Hydrocarbon Hydroxylases', 'Asian Continental Ancestry Group', 'Canada', 'China', 'Cytochrome P-450 CYP2A6', 'European Continental Ancestry Group', 'Exons', 'Gene Frequency', 'Genetic Variation', 'Genotype', 'Haplotypes', 'Humans', 'Japan', 'Korea', 'Mix... | 15,861,044 | [['Z01.058'], ['M01.686.508.100'], ['G05.360.340.024.340.030'], ['D08.244.453.005', 'D08.811.682.690.708.170.010', 'D12.776.422.220.453.010'], ['M01.686.508.200'], ['Z01.107.567.176'], ['Z01.252.474.164'], ['D08.244.453.491.250', 'D08.811.682.690.708.170.450.250', 'D12.776.422.220.453.491.250'], ['M01.686.508.400'], ['... | ['Geographicals [Z]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
Acute inflammation of the proliferative zone of gastric mucosa in Helicobacter pylori gastritis. | The neutrophilic infiltration has been regarded to represent the activity of Helicobacter pylori gastritis. It may involve the epithelium and/or lamina propria. The incidence and degree of the two types of infiltration do not correlate with each other frequently. We correlated the two types of neutrophilic infiltration... | ['Biopsy', 'Cell Division', 'Epithelium', 'Gastric Mucosa', 'Gastritis', 'Helicobacter Infections', 'Helicobacter pylori', 'Humans', 'Immunoenzyme Techniques', 'Incidence', 'Inflammation', 'Neutrophils'] | 10,549,033 | [['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A10.272'], ['A03.556.875.875.440', 'A10.615.550.291'], ['C06.405.205.697', 'C06.405.748.398'], ['C01... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Demonstration of erosive gastritis by the double-contrast technique. | The value of the routine pharmacologically-aided double-contrast examination of the upper gastrointestinal tract in demonstrating superficial gastric erosions was assessed. Ten cases of erosive gastritis were diagnosed during a six-month period. It appears that erosive gastritis is more common than generally believed. ... | ['Barium Sulfate', 'Gastric Mucosa', 'Gastritis', 'Humans', 'Radiography'] | 1,188,095 | [['D01.103.075', 'D01.875.800.800.850.075'], ['A03.556.875.875.440', 'A10.615.550.291'], ['C06.405.205.697', 'C06.405.748.398'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.700']] | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[The presence of CEA in spinocellular carcinoma of the oral cavity]. | Using an immunoperoxidase method the Authors have demonstrated carcinoembryonic antigen (CEA) in 4/7 patients with benign oral lesion and in 9/10 patients with oral cancer. All 4 oral leukoplakias were positive for CEA. The histologic presence of CEA in oral cancer was related mainly to the formation of well differenti... | ['Aged', 'Carcinoembryonic Antigen', 'Carcinoma, Squamous Cell', 'Female', 'Humans', 'Immunoenzyme Techniques', 'Leukoplakia', 'Male', 'Middle Aged', 'Mouth Neoplasms'] | 6,375,692 | [['M01.060.116.100'], ['D12.776.395.550.200.210', 'D12.776.543.550.200.210', 'D23.050.285.329', 'D23.050.301.350.210', 'D23.101.140.300'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.478.566.350', 'E05.478.583.400', 'E05.601.470.350'], ['C04.834.512', 'C23.300.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Time course of augmentation and depression of hypoxic ventilatory responses at altitude. | Hypoxic ventilatory response (HVR) and hypoxic ventilatory depression (HVD) were measured in six subjects before, during, and after 12 days at 3,810-m altitude (barometric pressure approximately 488 Torr) with and without 15 min of preoxygenation. HVR was tested by 5-min isocapnic steps to 75% arterial O2 saturation me... | ['Acclimatization', 'Adult', 'Altitude', 'Atmospheric Pressure', 'Carbon Dioxide', 'Chemoreceptor Cells', 'Humans', 'Hypoxia', 'Male', 'Oxygen', 'Respiratory Mechanics', 'Time Factors'] | 7,961,252 | [['G07.025.133', 'G16.012.500.133'], ['M01.060.116'], ['G16.500.275.058', 'N06.230.058'], ['G16.500.750.274', 'N06.230.300.100.185'], ['D01.200.200', 'D01.362.150', 'D01.650.550.200'], ['A08.675.650.915.500', 'A08.800.950.500', 'A11.671.650.915.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.888.852.079']... | ['Phenomena and Processes [G]', 'Named Groups [M]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Characterization of a new coagulase-negative Staphylococcus species (Staphylococcus pettenkoferi) isolated from blood cultures from a hospitalized patient in Porto Alegre, Brazil. | INTRODUCTION: Staphylococcus pettenkoferi was originally isolated and described by Tr?lzsch et al (2002). In this study, we characterized two isolates of this newly described species.METHODS: Blood cultures were initially processed using the BacT/ALERT(R) device, and the isolates were initially characterized using the ... | ['Coagulase', 'Humans', 'Male', 'Middle Aged', 'Staphylococcal Infections', 'Staphylococcus'] | 20,563,506 | [['D08.811.277.656.300.174', 'D12.776.097.181'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C01.150.252.410.868'], ['B03.300.390.400.800.750', 'B03.353.500.750.750', 'B03.510.100.750.750', 'B03.510.400.790.750']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Named Groups [M]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response. | Protein arginine methyltransferases (PRMTs) regulate diverse biological processes and are increasingly being recognized for their potential as drug targets. Here we report the discovery of a potent, selective, and cell-active chemical probe for PRMT7. SGC3027 is a cell permeable prodrug, which in cells is converted to ... | ['Animals', 'Arginine', 'Gene Knockdown Techniques', 'HCT116 Cells', 'HSP70 Heat-Shock Proteins', 'Humans', 'Methylation', 'Protein Processing, Post-Translational', 'Protein-Arginine N-Methyltransferases', 'Recombinant Proteins', 'Sf9 Cells', 'Stress, Physiological'] | 32,409,666 | [['B01.050'], ['D12.125.068.050', 'D12.125.095.104', 'D12.125.142.087'], ['E05.393.335.500'], ['A11.251.210.190.380', 'A11.251.860.180.380'], ['D12.776.580.216.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.111.035.538', 'G02.607.094.538', 'G03.059.538'], ['G02.111.660.871.790.600', 'G02.111.691.600', 'G... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mid-infrared and near-infrared spectroscopy for rapid detection of Gardeniae Fructus by a liquid-liquid extraction process. | Gardeniae Fructus is widely used in the pharmaceutical industry, and many studies have confirmed its medical and economic value. In this study, samples collected from different liquid-liquid extraction batches of Gardeniae Fructus were detected by mid-infrared (MIR) and near-infrared (NIR) spectroscopy. Seven analytes,... | ['Gardenia', 'Least-Squares Analysis', 'Liquid-Liquid Extraction', 'Spectroscopy, Near-Infrared'] | 28,645,015 | [['B01.650.940.800.575.912.250.456.937.388'], ['E05.318.740.750.400', 'N05.715.360.750.695.440', 'N06.850.520.830.750.400'], ['E05.196.155.650'], ['E01.370.350.750', 'E05.196.867.851']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Visuomotor deficits and fast recovery after area V6A lesion in monkeys. | In order to study the involvement of area V6A in visually guided behavior, restricted lesions to the anterior bank of the parieto-occipital sulcus (POs) were made in two adult Cercopithecus aethiops monkeys, trained in visuomotor tests. Beside the known clinical signs of parietal deficit (abnormal posture of the arm co... | ['Animals', 'Arm', 'Brain Mapping', 'Chlorocebus aethiops', 'Female', 'Hand', 'Kinesthesis', 'Male', 'Neural Pathways', 'Occipital Lobe', 'Orientation', 'Parietal Lobe', 'Psychomotor Performance', 'Space Perception', 'Task Performance and Analysis'] | 12,642,182 | [['B01.050'], ['A01.378.800.075'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['B01.050.150.900.649.313.988.400.112.199.120.126.110'], ['A01.378.800.667'], ['F02.830.816.541.504', 'G11.561.790.541.587'], ['A08.612'], ['A08.186.211.200.885.287.500.571'], ['F01.058.577', 'F02.830.606'], ['... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Causes of death in rural adult population of North India (2002-2007), using verbal autopsy tool. | BACKGROUND: With the on-going epidemiological transition, information on the pattern of mortality is important for health planning. Verbal autopsy (VA) is an established tool to ascertain the cause of death in areas where routine registration systems are incomplete or inaccurate. We estimated cause-specific mortality r... | ['Adolescent', 'Adult', 'Age Distribution', 'Autopsy', 'Cause of Death', 'Female', 'Humans', 'India', 'Male', 'Middle Aged', 'Rural Population', 'Sentinel Surveillance', 'Sex Distribution', 'Young Adult'] | 23,873,194 | [['M01.060.057'], ['M01.060.116'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['E01.370.060', 'E05.070', 'I01.198.780.937.120'], ['E05.318.308.985.550.250', 'N01.224.935.698.100', 'N06.850.505.400.975.550.250', 'N06.850.520.308.985.550.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.245.39... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Lymphomas involving the breast: a study of 106 cases comparing localized and disseminated neoplasms. | Lymphomas involving the breast account for approximately 2% of extranodal and <1% of all non-Hodgkin lymphomas. Our aim in this study was to classify breast lymphomas using the World Health Organization classification and then compare this classification with clinical, histologic, and radiologic findings as well as sur... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Breast Neoplasms', 'Breast Neoplasms, Male', 'Child', 'Child, Preschool', 'Female', 'Humans', 'Immunohistochemistry', 'Kaplan-Meier Estimate', 'Lymphoma', 'Male', 'Middle Aged'] | 18,636,016 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C04.588.180', 'C17.800.090.500'], ['C04.588.180.260', 'C17.800.090.500.260'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
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