Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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[Heterosensory interaction in neocortical neurons of the hedgehog, Erinaceus europaeus]. | Reactions of neurons in different areas have been investigated in the hedgehog cortex by means of the microelectrode technique. A wide dispersion of afferent inputs was shown over the whole neocortex, alongside with the existence of definite projection foci of appropriate modalities. In the specific projection zones th... | ['Animals', 'Association', 'Auditory Perception', 'Brain Mapping', 'Cerebral Cortex', 'Electrophysiology', 'Forelimb', 'Hedgehogs', 'Nose', 'Pain', 'Reaction Time', 'Sensation', 'Somatosensory Cortex', 'Visual Cortex', 'Visual Perception'] | 899,402 | [['B01.050'], ['F02.463.425.069', 'F04.754.720.346'], ['F02.463.593.071', 'G07.888.125'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['A08.186.211.200.885.287.500'], ['H01.158.344.528', 'H01.158.782.236'], ['A13.395'], ['B01.050.150.900.649.313.961.376'], ['A01.456.505.733', 'A04.531', '... | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Disciplines and Occupations [H]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Potential anticancer activity of myricetin in human T24 bladder cancer cells both in vitro and in vivo. | Myricetin, a naturally occurring phytochemical, has potent anticancer-promoting activity and contributes to the chemopreventive potential of several foods. In this preliminary study, we evaluate the chemopreventive potential of myricetin against bladder cancer and its mechanism of action. The results of a MTT assay sho... | ['Animals', 'Antineoplastic Agents', 'Apoptosis', 'Blotting, Western', 'CDC2 Protein Kinase', 'Caspase 3', 'Cell Cycle Checkpoints', 'Cell Line, Tumor', 'Cell Proliferation', 'Cyclin B1', 'Down-Regulation', 'Female', 'Flavonoids', 'Flow Cytometry', 'Humans', 'Mice', 'Mice, Inbred BALB C', 'Mice, Nude', 'Phosphorylation... | 22,482,362 | [['B01.050'], ['D27.505.954.248'], ['G04.146.954.035'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['D08.811.913.696.620.682.700.646.500.500.250', 'D08.811.913.696.620.682.700.646.500.984.500', 'D12.644.360.250.067.249', 'D12.644.360.250.580.500', 'D12.776.167.2... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Cloning and overexpression of lipase gene from Geotrichum candidum Y162]. | By means of bioinformatics, we aligned nucleotide sequence of reported lipase gene from Geotrichum. Primers were designed based on the conservative nucleotide sequence, and the lipase gene of G. candidum Y162 was cloned for the first time in China. Nucleotide sequencing revealed that the open reading frame has 1692 nuc... | ['Amino Acid Sequence', 'Cloning, Molecular', 'Enzyme Stability', 'Fungal Proteins', 'Gene Expression', 'Geotrichum', 'Lipase', 'Molecular Sequence Data', 'Pichia', 'Sequence Alignment'] | 18,437,999 | [['G02.111.570.060', 'L01.453.245.667.060'], ['E05.393.220'], ['E05.916.360', 'G02.111.700.500'], ['D12.776.354'], ['G05.297'], ['B01.300.381.380'], ['D08.811.277.352.100.400'], ['L01.453.245.667'], ['B01.300.107.795.700', 'B01.300.930.600'], ['E05.393.751']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Zeta Potential Changing Polyphosphate Nanoparticles: A Promising Approach To Overcome the Mucus and Epithelial Barrier. | The aim of the present study was to develop zeta potential-changing polyphosphate nanoparticles (pp-NPs) in order to overcome the diffusion barrier of the mucus gel layer and to provide an enhanced cellular uptake. pp-NPs were obtained by in situ gelation between cationic polyethylene imine and anionic polyphosphate. T... | ['Animals', 'Caco-2 Cells', 'Cell Survival', 'Drug Delivery Systems', 'Humans', 'Intestines', 'Microscopy, Electron, Scanning', 'Nanoparticles', 'Particle Size', 'Polyethyleneimine', 'Polyphosphates', 'Swine'] | 31,070,926 | [['B01.050'], ['A11.251.210.190.160', 'A11.251.860.180.160', 'A11.436.140'], ['G04.346'], ['E02.319.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A03.556.124'], ['E01.370.350.515.402.541', 'E05.595.402.541'], ['J01.637.512.600'], ['G02.712'], ['D02.455.326.271.665.550.600', 'D02.491.650', 'D05.750.716.507.6... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Ototoxicity of cisplatin. | Ototoxicity is one of the unwanted side effects of cisplatin treatment. The first sign of hearing loss usually appears 3-4 days after the drug administration and occurs primarily in the higher frequencies. One hundred and eighty-six women treated with a moderate dose of cisplatin (50 mg/m2 every 4 weeks) for gynaecolog... | ['Animals', 'Cisplatin', 'Cochlea', 'Female', 'Genital Neoplasms, Female', 'Hearing Loss', 'Hearing Loss, High-Frequency', 'Humans', 'Risk'] | 3,583,423 | [['B01.050'], ['D01.210.375', 'D01.625.125', 'D01.710.100'], ['A09.246.300.246'], ['C04.588.945.418', 'C13.351.937.418'], ['C09.218.458.341', 'C10.597.751.418.341', 'C23.888.592.763.393.341'], ['C09.218.458.341.812', 'C10.597.751.418.341.812', 'C23.888.592.763.393.341.812'], ['B01.050.150.900.649.313.988.400.112.400.40... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Impact of diabetes on employment and income in Manitoba, Canada. | OBJECTIVE: To compare employment and income of working-age (18-64 years) people with and without diabetes.RESEARCH DESIGN AND METHODS: We conducted a prospective population-based cohort study based in Manitoba, Canada, consisting of 25,554 individuals without diabetes and 608 with diabetes, of whom 242 had a complicati... | ['Adult', 'Cohort Studies', 'Diabetes Complications', 'Educational Status', 'Employment', 'European Continental Ancestry Group', 'Female', 'Humans', 'Income', 'Indians, North American', 'Inuits', 'Male', 'Manitoba', 'Middle Aged', 'Occupations', 'Odds Ratio', 'Prospective Studies', 'Rural Population', 'Urban Population... | 11,194,243 | [['M01.060.116'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['C19.246.099'], ['N01.824.196'], ['N01.824.245'], ['M01.686.508.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N01.824.417'], ['M01.686.508.150.600'], ['M01.686.508.150.600.375.500', 'M01.686.508.150.675', 'M01.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Soft-start polymerization of fissure sealant: retention after three years. | The aim of this study was to investigate retention of composite fissure sealant polymerized with standard and soft-start technique after a three year clinical trial. One hundred teeth were divided into two groups (A&B) of teeth and sealed with composite material (Visioseal, 3M Espe) using split mouth design. Sealants w... | ['Child', 'Dental Caries', 'Dental Fissures', 'Follow-Up Studies', 'Humans', 'Pit and Fissure Sealants', 'Polymers'] | 18,217,464 | [['M01.060.406'], ['C07.793.720.210'], ['C07.793.720.210.220'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D25.339.773', 'J01.637.051.339.773'], ['D05.750', 'D25.720', 'J01.637.051.720']] | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Daily urinary free cortisol and cortisone excretion is associated with urine volume in healthy children. | BACKGROUND: In experimental studies, a high fluid intake and a corresponding high urine volume have been shown to increase renal excretion rates of urinary free cortisol (UFF) and cortisone (UFE) in adults. We aimed to examine whether 24-h UFF and UFE excretion rates are also affected by urine volume in children.METHOD... | ['Adolescent', 'Child', 'Cortisone', 'Cross-Sectional Studies', 'Female', 'Glucocorticoids', 'Humans', 'Hydrocortisone', 'Male', 'Radioimmunoassay'] | 18,762,206 | [['M01.060.057'], ['M01.060.406'], ['D04.210.500.745.745.183', 'D06.472.040.585.478.195'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['D06.472.040.543', 'D27.505.696.399.472.488'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D04.210.500.745.745.654.600', 'D06.472.040.585.353.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Lung cancer in a health area of Spain: incidence, characteristics and survival. | To examine the incidence, characteristics, therapeutic approach and survival of diagnosed lung cancer (LC) in the Santiago de Compostela Health Area. A retrospective study was carried out on LC for a period of 3 years. Of the 481 cases collected, 92.7% were male. The median age was 66.93 years. The crude incidence for ... | ['Adult', 'Age Distribution', 'Aged', 'Aged, 80 and over', 'Carcinoma, Squamous Cell', 'Female', 'Health Surveys', 'Humans', 'Incidence', 'Lung Neoplasms', 'Male', 'Middle Aged', 'Retrospective Studies', 'Sex Distribution', 'Smoking', 'Spain', 'Survival Rate'] | 19,709,170 | [['M01.060.116'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['E05.318.308.980.438', 'N05.715.360.300.800.438', 'N06.850.520.308.980.438'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Extracranial contamination in the INVOS 5100C versus the FORE-SIGHT ELITE cerebral oximeter: a prospective observational crossover study in volunteers. | PURPOSE: Previous studies have found that most cerebral oximeters are subject to inaccuracies secondary to extracranial contamination of the cerebral oximetric signals. We hypothesized that the more advanced second-generation FORE-SIGHT ELITE cerebral oximeter would be significantly less affected by extracranial tissue... | ['Adolescent', 'Adult', 'Brain', 'Cross-Over Studies', 'Female', 'Healthy Volunteers', 'Humans', 'Male', 'Middle Aged', 'Oximetry', 'Prospective Studies', 'Young Adult'] | 26,307,186 | [['M01.060.057'], ['M01.060.116'], ['A08.186.211'], ['E05.318.370.150', 'N05.715.360.325.150', 'N06.850.520.445.150'], ['M01.774.500', 'M01.955.236'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.370.225.124.100.100.600', 'E01.370.370.380.600', 'E01.370.386.700.100.600', 'E05.200.124.100.... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Lactobacillus plantarum CCFM8661 modulates bile acid enterohepatic circulation and increases lead excretion in mice. | The management of lead (Pb) exposure and toxicity remains a major public health priority worldwide. In our previous study, the probiotic strain Lactobacillus plantarum CCFM8661 prevented Pb absorption in mice via intestinal sequestration. This follow-up study aimed to evaluate the additional protective mechanism of L. ... | ['Animals', 'Bile Acids and Salts', 'Feces', 'Gene Expression Regulation', 'Kidney', 'Lactobacillus plantarum', 'Lead', 'Liver', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Probiotics', 'RNA, Messenger', 'Random Allocation'] | 30,768,114 | [['B01.050'], ['D04.210.500.105'], ['A12.459'], ['G05.308'], ['A05.810.453'], ['B03.353.750.450.475.612', 'B03.510.460.400.410.475.475.612', 'B03.510.550.450.475.612'], ['D01.268.556.435', 'D01.552.544.435'], ['A03.620'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Measurement of ion transport function in rectal biopsies. | Cystic fibrosis (CF) is caused by mutations in the gene encoding for the cystic fibrosis transmembrane conductance regulator (CFTR). CFTR functions as an anion channel and is known to interact with a number of other cellular proteins involved in ion transport. To date more than 1,800 mutations are known, most of which ... | ['Biopsy', 'Cystic Fibrosis', 'Cystic Fibrosis Transmembrane Conductance Regulator', 'Drug Discovery', 'Electric Conductivity', 'Electrophysiology', 'Humans', 'Ion Transport', 'Rectum'] | 21,594,780 | [['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['C06.689.202', 'C08.381.187', 'C16.320.190', 'C16.614.213'], ['D12.776.157.530.100.304.500', 'D12.776.157.530.400.175.125', 'D12.776.157.530.450.074.500.500.500.500', 'D12.776... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
A study of enzymatic activity in cell cultures via the analysis of volatile biomarkers. | Aldehyde dehydrogenase (ALDH) enzymes are responsible for the metabolism of aldehydes, including acetaldehyde (AA), and are linked to disease. We describe a method to study ALDH activity in cell cultures involving the measurement of AA concentrations in the gas/vapour phase. This has been achieved using selected ion fl... | ['Aldehyde Dehydrogenase', 'Amino Acids', 'Biomarkers', 'Cell Survival', 'Cells, Cultured', 'Disulfiram', 'Gases', 'Hep G2 Cells', 'Humans', 'Mass Spectrometry', 'Mesenchymal Stem Cells', 'Methionine Sulfoxide Reductases', 'Sulfides'] | 22,930,361 | [['D08.811.682.657.163.249'], ['D12.125'], ['D23.101'], ['G04.346'], ['A11.251'], ['D02.241.081.251.869.220.250', 'D02.886.520.150.175', 'D02.886.706.200.200'], ['D01.362'], ['A11.251.860.180.432', 'A11.436.348.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.196.566'], ['A11.329.830.500', 'A11.872.590.500... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effectiveness of single-surface ART restorations in the permanent dentition: a meta-analysis. | Over the past few years, there has been an increase in the number of studies reporting on various aspects of the Atraumatic Restorative Treatment (ART) approach. Five randomized clinical trials in which ART restorations with glass ionomers were compared with amalgam restorations in permanent teeth for a maximum period ... | ['Confidence Intervals', 'Dental Amalgam', 'Dental Restoration, Permanent', 'Glass Ionomer Cements', 'Humans', 'Randomized Controlled Trials as Topic', 'Survival Analysis', 'Time Factors'] | 14,742,648 | [['E05.318.740.275', 'N05.715.360.750.220', 'N06.850.520.830.275'], ['D25.339.208.291', 'J01.637.051.339.208.291'], ['E06.323.428', 'E06.780.346.737', 'E07.695.190.190'], ['D25.339.291.402', 'J01.637.051.339.291.402'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.250.250.365.500', 'N05.715.360.330.250... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Percutaneous infraclavicular subclavian catheterization. | A series of 510 percutaneous infraclavicular subclavian venipunctures performed by the authors is presented. Complications included five cases of simple pneumothorax (0.98%) and one instance of subcutaneous emphysema without pneumothorax (0.20%). No mortality was associated with the procedure. | ['Catheterization', 'Clavicle', 'Humans', 'Pneumothorax', 'Subclavian Vein', 'Subcutaneous Emphysema'] | 7,081,839 | [['E02.148', 'E05.157'], ['A02.835.232.087.227'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C08.528.778'], ['A07.015.908.877'], ['C23.550.325.500']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Evaluation of three full-scale stormwater treatment systems with respect to water yield, pathogen removal efficacy and human health risk from faecal pathogens. | In this study, three full-scale, operational stormwater harvesting systems located in Melbourne, Australia were evaluated with respect to water yields; pathogen removal performance by analysis of native surrogate data (Escherichiacoli, somatic coliphages and Clostridium perfringens); and potential human health risk ass... | ['Australia', 'Coliphages', 'Environmental Monitoring', 'Feces', 'Humans', 'Risk Assessment', 'Waste Disposal, Fluid', 'Waste Water', 'Water Microbiology'] | 26,615,487 | [['Z01.639.100', 'Z01.678.100.373'], ['B04.123.205'], ['N06.850.460.350.080', 'N06.850.780.375'], ['A12.459'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.600.800.715', 'N04.452.871.715', 'N05.715.360.750.625.700.690', 'N06.850.505.715', 'N06.850.520.830.600.800.715'], ['N06.850.780.200.800.800.890',... | ['Geographicals [Z]', 'Organisms [B]', 'Health Care [N]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
[The prognostic role of interleukin-6 in peritoneal exudate of patients with diffuse peritonitis]. | A prospective longitudinal controlled investigation of 189 patients with secondary diffuse peritonitis was performed. A correlation between the levelof interleuikin-6 of peritoneal exudate, the severity of the patients' state, the number of complications and outcome of the course of the disease was established. The max... | ['Exudates and Transudates', 'Female', 'Follow-Up Studies', 'Humans', 'Interleukin-6', 'Male', 'Middle Aged', 'Peritoneal Cavity', 'Peritonitis', 'Prognosis', 'Prospective Studies', 'Severity of Illness Index'] | 20,020,622 | [['A12.383'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.465.224', 'D12.776.467.374.465.202', 'D23.529.374.465.224'], ['M01.060.116.630'], ['A01.923.047.025.600.678'], ['C01.463.600', 'C06.844.640'], ['E01... | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Named Groups [M]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Cytomegalovirus seroconversion as a cofactor for progression to AIDS. | OBJECTIVE: To study the impact of cytomegalovirus (CMV) seroconversion on HIV-1 disease progression.DESIGN: Follow-up of CMV-seronegative subjects enrolled in the French SEROCO/HEMOCO cohorts of HIV-infected subjects.METHODS: A total of 290 subjects were CMV-seronegative at enrolment in the cohort. Serological testing ... | ['AIDS-Related Opportunistic Infections', 'Acquired Immunodeficiency Syndrome', 'Adult', 'Cohort Studies', 'Cytomegalovirus Infections', 'Disease Progression', 'HIV-1', 'Humans', 'Incidence', 'Risk Factors'] | 11,216,935 | [['C01.221.250.875.100', 'C01.597.050', 'C01.610.684.050', 'C01.925.597.050', 'C01.925.782.815.616.400.100', 'C20.673.480.100'], ['C01.221.250.875.040', 'C01.221.812.640.400.040', 'C01.778.640.400.040', 'C01.925.782.815.616.400.040', 'C01.925.813.400.040', 'C01.925.839.040', 'C20.673.480.040'], ['M01.060.116'], ['E05.3... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Melanocortin receptors as targets in the treatment of obesity. | The central melanocortin system plays a critical role in energy homeostasis. It is well established that melanocortin-containing neurons are nutritionally regulated and that genetic alterations in the melanocortin system produce profound effects on food intake, energy expenditure, and body weight. Within the brain, mel... | ['Animals', 'Drug Design', 'Humans', 'Melanocortins', 'Obesity', 'Receptors, Melanocortin', 'Signal Transduction'] | 17,584,129 | [['B01.050'], ['E05.290.500', 'H01.158.703.007.338.500', 'H01.181.466.338.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D06.472.699.327.935.531', 'D06.472.699.631.525.600.531', 'D12.644.400.400.935.531', 'D12.644.548.365.935.531', 'D12.644.548.691.525.690.531', 'D12.776.631.650.405.935.531'], ['C18.654.726.... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Selective approach to sternal closure after exploration for hemorrhage following coronary artery bypass. | Thirty-six (4.6%) patients required exploration for hemorrhage after 788 coronary artery bypass grafting procedures. Twenty-three (64%) patients with a specific site of bleeding that was surgically controlled or with improving coagulopathy were managed by immediate sternal closure. Continued hemorrhage or tamponade nec... | ['Adult', 'Aged', 'Coronary Artery Bypass', 'Female', 'Hemorrhage', 'Humans', 'Length of Stay', 'Male', 'Middle Aged', 'Reoperation', 'Sternum', 'Time Factors'] | 2,339,933 | [['M01.060.116'], ['M01.060.116.100'], ['E04.100.376.719.332', 'E04.100.814.868.750', 'E04.928.220.520.220'], ['C23.550.414'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.760.400.480', 'N02.421.585.400.480'], ['M01.060.116.630'], ['E04.690'], ['A02.835.232.570.750'], ['G01.910.857']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Why lipostatic set point systems are unlikely to evolve. | OBJECTIVES: Body fatness is widely assumed to be regulated by a lipostatic set-point system, which has evolved in response to trade-offs in the risks of mortality. Increasing fatness makes the risk of starvation lower but increases the risk of predation. Yet other models are available. The aim of this work is to evalua... | ['Adiposity', 'Animals', 'Homeostasis', 'Humans', 'Leptin', 'Models, Theoretical', 'Obesity'] | 29,129,612 | [['E01.370.600.115.100.062.500', 'G02.111.130.134.500', 'G03.180.134.500', 'G07.100.049.134.500'], ['B01.050'], ['G07.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D06.472.699.042.500', 'D12.644.276.024.500', 'D12.644.548.011.500', 'D12.776.467.024.500', 'D23.529.024.500'], ['E05.599'], ['C18.654.726.500', ... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Reduction of the ex vivo production of tumor necrosis factor alpha by alveolar phagocytes after administration of coal fly ash and copper smelter dust. | We investigated the effect of intratracheally instilled coal fly ash (FA) and copper smelter dust (CU) on the lung integrity and on the ex vivo release of tumor necrosis factor alpha (TNF-alpha) by alveolar phagocytes. Groups of female NMRI mice received a single intratracheal administration of different particles norm... | ['Animals', 'Arsenic', 'Bronchoalveolar Lavage Fluid', 'Carbon', 'Coal', 'Coal Ash', 'Copper', 'Female', 'Intubation, Intratracheal', 'Lung', 'Mice', 'Mice, Inbred Strains', 'Particle Size', 'Particulate Matter', 'Phagocytes', 'Proteins', 'Pulmonary Alveoli', 'Tumor Necrosis Factor-alpha', 'Up-Regulation'] | 9,176,558 | [['B01.050'], ['D01.268.513.249'], ['E05.927.100.500'], ['D01.268.150'], ['D20.345.108', 'N06.230.132.258.108'], ['D20.633.110'], ['D01.268.556.195', 'D01.268.956.170', 'D01.552.544.195'], ['E02.041.500', 'E02.585.578', 'E05.497.578'], ['A04.411'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520'... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Hypoglycaemia: causes, risk factors and pathophysiology. | This article examines the prevalence, symptoms, risk factors, management and prevention of hypoglycaemia in adults. Relevant research and government policies are discussed, and recent guidelines on the management of hypoglycaemia are presented. Standard 7 of the National Service Framework for Diabetes focuses on the ne... | ['Humans', 'Hypoglycemia', 'Prevalence', 'Risk Factors', 'United Kingdom'] | 23,930,531 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['C18.452.394.984'], ['E05.318.308.985.525.750', 'N01.224.935.597.750', 'N06.850.505.400.975.525.750', 'N06.850.520.308.985.525.750'], ['E05.318.740.600.800.725', 'N05.715.350.200.700', 'N05.715.360.750.625.700.700', 'N06.850.490.625.750', 'N06.850.520.830.600.800.725']... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Influence of insulin-like growth factor I and nutrition during phases of postnatal growth in very preterm infants. | Pronounced growth restriction (GR) occurs after very preterm birth. The interaction between IGF-I, nutritional intake, and growth was evaluated prospectively in 64 infants with a mean (SD) GA of 25.7 (1.9) wk. Blood sampling of IGF-I and measurements of weight, length, and head circumference were performed weekly until... | ['Anti-Inflammatory Agents', 'Betamethasone', 'Biomarkers', 'Body Height', 'Body Size', 'Body Weight', 'Breast Feeding', 'Cephalometry', 'Dietary Proteins', 'Energy Intake', 'Female', 'Gestational Age', 'Head', 'Humans', 'Hydrocortisone', 'Infant Nutritional Physiological Phenomena', 'Infant, Newborn', 'Infant, Prematu... | 21,263,374 | [['D27.505.954.158'], ['D04.210.500.745.432.769.199', 'D04.210.500.908.093'], ['D23.101'], ['E01.370.600.115.100.160.100', 'E05.041.124.160.500', 'G07.100.100.160.100', 'G07.345.249.314.100'], ['E01.370.600.115.100.160', 'E05.041.124.160', 'G07.100.100.160', 'G07.345.249.314'], ['C23.888.144', 'E01.370.600.115.100.160.... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Organisms [B]', 'Named Groups [M]', 'Geographicals [Z]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
The action of epinephrine on Madin-Darby canine kidney cells. | We have used cultured monolayers of Madin-Darby canine kidney (MDCK) cells, which form epithelial layers of high transepithelial resistance, grown on Millipore filters, for transport studies. In the absence of hormones net ion transport is of small magnitude and is consistent with a net absorptive flow (apical to basal... | ['Adenylyl Cyclases', 'Animals', 'Biological Transport, Active', 'Cell Line', 'Chlorides', 'Cyclic AMP', 'Dogs', 'Electric Conductivity', 'Epinephrine', 'Epithelium', 'Kidney', 'Kinetics', 'Models, Biological'] | 6,325,249 | [['D08.811.520.650.200', 'D12.644.360.050', 'D12.776.476.050'], ['B01.050'], ['G03.143.310'], ['A11.251.210'], ['D01.210.450.150', 'D01.248.497.158.215'], ['D03.633.100.759.646.138.395', 'D13.695.462.200', 'D13.695.667.138.395', 'D13.695.827.068.395'], ['B01.050.150.900.649.313.750.250.216.200'], ['G01.358.500.249.277'... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Investigating drug use in pregnancy. Methodological problems and perspectives. | In this study the use of prescribed drugs before, during and after pregnancy is described. The study is based on data obtained from pharmacy records of 1,948 women who delivered a live-born infant. Different measures to evaluate drug exposure are used. During the nine months of pregnancy 86% of the women used on averag... | ['Adult', 'Drug Utilization', 'Female', 'Humans', 'Pharmaceutical Preparations', 'Pregnancy', 'Risk'] | 2,034,515 | [['M01.060.116'], ['N04.452.706.477'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D26'], ['G08.686.784.769'], ['E05.318.740.600.800', 'G17.680.750', 'N05.715.360.750.625.700', 'N06.850.520.830.600.800']] | ['Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Interleukin-6 and transforming growth factor-beta synergistically stimulate chondrosarcoma cell proliferation. | This study examines the regulation of Swarm rat chondrosarcoma (SRC) cell proliferation in vitro. In serum-free cultures, SRC cells showed only transient DNA synthesis and this was increased by serum. Transforming growth factor-beta (TGF-beta) was identified as an essential serum component, since the mitogenic effect o... | ['Animals', 'Blood', 'Cell Division', 'Cell Line', 'Chondrosarcoma', 'Culture Media', 'DNA, Neoplasm', 'Drug Synergism', 'Growth Substances', 'Interleukin-6', 'Rats', 'Receptors, Immunologic', 'Receptors, Interleukin-6', 'Transforming Growth Factor beta', 'Tumor Cells, Cultured'] | 1,939,340 | [['B01.050'], ['A12.207.152', 'A15.145'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.251.210'], ['C04.557.450.565.280', 'C04.557.450.795.300'], ['D27.720.470.305', 'E07.206'], ['D13.444.308.425'], ['G07.690.773.968.477'], ['D27.505.696.377'], ['D12.644.276.374.465.224', 'D12.776.467... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Responsibility in medical collaborations and care establishments]. | Criminal Law and Civil Law--that have a general application require personnel misconduct. However, the criminal liability of legal entities is now provided by the law. Public law only deals with the liability of the establishment as a consequence of a fault of the administrative service or of a personnel misconduct. Th... | ['France', 'Hospital Administration', 'Liability, Legal', 'Malpractice', 'Patient Care Team', 'Quality of Health Care'] | 9,673,049 | [['Z01.542.286'], ['H02.309', 'N02.278.216.500', 'N04.452.442.452'], ['I01.880.604.583.490', 'N03.706.535.547'], ['I01.880.604.583.524', 'N03.706.535.606'], ['N04.590.715'], ['N04.761', 'N05.715']] | ['Geographicals [Z]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 |
Influenza vaccine effectiveness against hospitalisation with confirmed influenza in the 2010-11 seasons: a test-negative observational study. | Immunisation programs are designed to reduce serious morbidity and mortality from influenza, but most evidence supporting the effectiveness of this intervention has focused on disease in the community or in primary care settings. We aimed to examine the effectiveness of influenza vaccination against hospitalisation wit... | ['Adult', 'Female', 'Hospitalization', 'Humans', 'Influenza Vaccines', 'Influenza, Human', 'Male', 'Middle Aged', 'Treatment Outcome', 'Vaccination'] | 23,874,754 | [['M01.060.116'], ['E02.760.400', 'N02.421.585.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D20.215.894.899.302'], ['C01.748.310', 'C01.925.782.620.365', 'C08.730.310'], ['M01.060.116.630'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800'], ['E02.095.465.425.400.530.890', 'E05.478.550.600.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Kinetics of drug action in disease states. XX. Effects of acute starvation on the pharmacodynamics of phenobarbital, ethanol and pentylenetetrazol in rats and effects of refeeding and diet composition. | Severely ill patients often do not eat or cannot retain ingested food. Malnutrition occurs frequently in hospitalized individuals and is known to be associated with substantial changes in the pharmacokinetics of certain drugs. On the other hand, little is known about the effect of acute starvation or malnutrition on th... | ['Animals', 'Blood Proteins', 'Body Weight', 'Central Nervous System', 'Diet', 'Dietary Carbohydrates', 'Dietary Proteins', 'Ethanol', 'Food', 'Kinetics', 'Male', 'Pentylenetetrazole', 'Phenobarbital', 'Protein Binding', 'Rats', 'Rats, Inbred Strains', 'Starvation'] | 3,612,521 | [['B01.050'], ['D12.776.124'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['A08.186'], ['G07.203.650.240'], ['D09.301', 'G07.203.300.362', 'J02.500.362'], ['D12.776.256', 'G07.203.300.428', 'J02.500.428'], ['D02.033.375'], ['G07.203.300', 'J02.50... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Diazepam prophylaxis for bicuculline-induced seizures: a rat dose-response model. | We developed a screening methodology to test the ability of putative antiepileptic drugs delivered directly to a seizure focus to prevent epileptiform activity. The left hippocampi of 15 rats were implanted with an injection cannula and bipolar recording electrodes. Bone screws were used to record neocortical EEG activ... | ['Action Potentials', 'Animals', 'Bicuculline', 'Diazepam', 'Disease Models, Animal', 'Dose-Response Relationship, Drug', 'Hippocampus', 'Male', 'Rats', 'Rats, Sprague-Dawley', 'Seizures'] | 14,746,903 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['B01.050'], ['D03.132.098.077', 'D03.633.100.531.085.077'], ['D03.633.100.079.080.070.216'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['G07.690.773.875', 'G07.690.936.500'], ['A08.186.211.180.405', 'A08.186.211.200.885.287.500.345'], ['B01.050.150.900.649.3... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
CYLD suppression enhances the pro-inflammatory effects and hyperproliferation of rheumatoid arthritis fibroblast-like synoviocytes by enhancing NF-êB activation. | BACKGROUND: Rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs) actively drive joint inflammation and degradation by producing inflammatory cytokines and matrix-degrading molecules, making them key factors in the pathogenesis of RA. Cylindromatosis (CYLD) is a tumor suppressor that downregulates nuclear factor ... | ['Arthritis, Rheumatoid', 'Cell Proliferation', 'Cells, Cultured', 'Deubiquitinating Enzyme CYLD', 'Female', 'Fibroblasts', 'Humans', 'Inflammation Mediators', 'Male', 'Middle Aged', 'NF-kappa B', 'Synoviocytes'] | 30,285,829 | [['C05.550.114.154', 'C05.799.114', 'C17.300.775.099', 'C20.111.199'], ['G04.161.750', 'G07.345.249.410.750'], ['A11.251'], ['D08.811.037.375', 'D12.776.624.776.482'], ['A11.329.228'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D23.469'], ['M01.060.116.630'], ['D05.500.672', 'D12.776.260.600', 'D12.776.660.600'... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Named Groups [M]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Linking cell cycle to histone modifications: SBF and H2B monoubiquitination machinery and cell-cycle regulation of H3K79 dimethylation. | To identify regulators involved in determining the differential pattern of H3K79 methylation by Dot1, we screened the entire yeast gene deletion collection by GPS for genes required for normal levels of H3K79 di- but not trimethylation. We identified the cell cycle-regulated SBF protein complex required for H3K79 dimet... | ['Cell Cycle', 'DNA, Intergenic', 'DNA-Binding Proteins', 'Gene Expression Profiling', 'Gene Expression Regulation, Fungal', 'Histone-Lysine N-Methyltransferase', 'Histones', 'Lysine', 'Methylation', 'Nuclear Proteins', 'Oligonucleotide Array Sequence Analysis', 'Open Reading Frames', 'Promoter Regions, Genetic', 'Prot... | 19,682,934 | [['G04.144'], ['D13.444.308.324', 'G05.360.340.024.220'], ['D12.776.260'], ['E05.393.332'], ['G05.308.330'], ['D08.811.913.555.500.800.200.500'], ['D12.776.157.687.485', 'D12.776.660.720.485', 'D12.776.664.469'], ['D12.125.068.555', 'D12.125.095.647', 'D12.125.142.497'], ['G02.111.035.538', 'G02.607.094.538', 'G03.059.... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The effects of crowding stress on the growth, physiological response, and gene expression of the Nrf2-Keap1 signaling pathway in blunt snout bream (Megalobrama amblycephala) reared under in-pond raceway conditions. | We evaluated the effects of high density stress on growth performance, antioxidant parameters, and Nrf2 pathway signaling molecules after different lengths of exposure (30, 60, or 90 days) of Megalobrama amblycephala to in-pond raceway aquaculture systems (IPRS). M. amblycephala (average initial weight 2.33 ± 0.15 g) w... | ['Animals', 'Antioxidants', 'Aquaculture', 'Cyprinidae', 'Fish Proteins', 'Gene Expression', 'Kelch-Like ECH-Associated Protein 1', 'Liver', 'NF-E2-Related Factor 2', 'Oxidative Stress', 'Signal Transduction'] | 30,641,189 | [['B01.050'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['J01.040.168'], ['B01.050.150.900.493.200.244'], ['D12.776.325'], ['G05.297'], ['D12.644.360.024.306', 'D12.776.157.057.067', 'D12.776.476.024.387'], ['A03.620'], ['D12.776.260.108.737', 'D12.776.930.127.737'], ['G03.673', 'G07.775.750'], ['G... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Preservation of rat hepatic microsomal enzyme activities: effect of low temperature and freeze-drying. | About 30-70% of microsomal hydroxylation of aniline, 0-demethylation of 4-NO2-anisole, N-demethylation of aminopyrine, were lost when whole organs were frozen and kept at low temperatures (0 degrees, -20 degrees, -196 degrees C). When 9000 X g or 105000 X g fractions were prepared from fresh liver and subsequently froz... | ['Aminopyrine', 'Aniline Compounds', 'Animals', 'Calcium', 'Cold Temperature', 'Cytochromes', 'Freeze Drying', 'Hydroxylation', 'Male', 'Microsomes, Liver', 'Rats', 'Time Factors', 'Tissue Preservation'] | 7,392,658 | [['D03.383.129.539.850.077'], ['D02.092.146'], ['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['G01.906.595.272', 'G16.500.275.063.725.710.300', 'G16.500.750.775.710.300', 'N06.230.300.100.725.154', 'N06.230.300.100.725.710.300'], ['D08.244', 'D12.776.422.220'], ['E01.370.225.500.620.760.160.260', ... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
A prospective study of XELOX plus bevacizumab as first-line therapy in Japanese patients with metastatic colorectal cancer (KSCC 0902). | BACKGROUND: This study was designed to evaluate the efficacy and safety of XELOX plus bevacizumab in a Japanese metastatic colorectal cancer population that included elderly patients.METHODS: This was a multicenter, single-arm, open-label prospective study. The major inclusion criteria were previously untreated metasta... | ['Adult', 'Aged', 'Aged, 80 and over', 'Anemia', 'Anorexia', 'Antineoplastic Combined Chemotherapy Protocols', 'Bevacizumab', 'Capecitabine', 'Colorectal Neoplasms', 'Deoxycytidine', 'Disease-Free Survival', 'Fatigue', 'Female', 'Fluorouracil', 'Humans', 'Japan', 'Male', 'Middle Aged', 'Neutropenia', 'Organoplatinum Co... | 26,338,269 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C15.378.071'], ['C23.888.821.108'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['D12.776.124.486.485.114.224.060.375', 'D12.776.124.790.651.114.224.060.438', 'D12.776.377.715.548.114.224.200.438'], ['D03.383.742.680.245.500.425', 'D03.383... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
[Secondary traumatic diaphragmatic hernia with incarceration--a diagnostic problem]. | In this paper we discuss the case of a 64-year-old patient suffering from a traumatic rupture of the diaphragm with delayed manifestation three years after the trauma. The subsequent diagnostic errors gave rise to a discussion of the value of the physical examination, imaging methods and invasive diagnostic methods, pa... | ['Arrhythmias, Cardiac', 'Diagnosis, Differential', 'Follow-Up Studies', 'Gastrectomy', 'Hernia, Diaphragmatic, Traumatic', 'Humans', 'Jejunum', 'Male', 'Middle Aged', 'Pacemaker, Artificial', 'Pneumothorax', 'Thoracic Injuries', 'Tomography, X-Ray Computed', 'Wounds, Nonpenetrating'] | 7,634,962 | [['C14.280.067', 'C23.550.073'], ['E01.171'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['E04.210.419'], ['C23.300.707.960.500.233', 'C26.017.258'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A03.556.124.684.500', 'A03.556.249.750'], ['M01.060.116.630'], ['E07.30... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Named Groups [M]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Attentional prioritization of infant faces is limited to own-race infants. | BACKGROUND: Recent evidence indicates that infant faces capture attention automatically, presumably to elicit caregiving behavior from adults and leading to greater probability of progeny survival. Elsewhere, evidence demonstrates that people show deficiencies in the processing of other-race relative to own-race faces.... | ['Adolescent', 'Adult', 'Asian Continental Ancestry Group', 'Attention', 'Caregivers', 'European Continental Ancestry Group', 'Face', 'Female', 'Humans', 'Infant', 'Male', 'Recognition, Psychology', 'Young Adult'] | 20,824,137 | [['M01.060.057'], ['M01.060.116'], ['M01.686.508.200'], ['F02.830.104.214'], ['M01.085', 'M01.526.485.200', 'N02.360.200'], ['M01.686.508.400'], ['A01.456.505'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['F02.463.425.540.706'], ['M01.060.116.815']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Total prostatectomy for localized prostatic cancer. | Several treatment options currently are available for the patient with clinically localized carcinoma of the prostate and each has its proponents. Comparison of results between institutions becomes necessary to determine the relative value of these treatments, keeping in mind the absence of a suitable control group in ... | ['Adenocarcinoma', 'Aged', 'Erectile Dysfunction', 'Follow-Up Studies', 'Humans', 'Male', 'Neoplasm Staging', 'Postoperative Complications', 'Prostatectomy', 'Prostatic Neoplasms', 'Urinary Incontinence'] | 6,690,752 | [['C04.557.470.200.025'], ['M01.060.116.100'], ['C12.294.644.486', 'F03.835.400'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.789.625'], ['C23.550.767'], ['E04.950.774.860.625'], ['C04.588.945.440.770', 'C12.294.260.7... | ['Diseases [C]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Differences in white matter structure between seizure prone (FAST) and seizure resistant (SLOW) rat strains. | Alterations in white matter integrity have been well documented in chronic epilepsy and during epileptogenesis. However, the relationship between white matter integrity and a predisposition towards epileptogenesis has been understudied. The FAST rat strain exhibit heightened susceptibility towards kindling epileptogene... | ['Analysis of Variance', 'Animals', 'Anisotropy', 'Cohort Studies', 'Diffusion Tensor Imaging', 'Disease Models, Animal', 'Drinking', 'Electric Stimulation', 'Exploratory Behavior', 'Image Processing, Computer-Assisted', 'Locomotion', 'Male', 'Myelin Sheath', 'Rats', 'Seizures', 'White Matter'] | 28,473,263 | [['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['B01.050'], ['G01.590.040', 'G02.050'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E01.370.350.578.750', 'E01.370.350.825.500.150.500', 'E01.370.376.537.500', 'E05.629.750'], ['C22.232', 'E05.598.500', 'E05.599.39... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Information Science [L]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Smoking cessation and stress among teenagers. | The authors describe the experience of quitting smoking, focusing on the obstacles youth struggle with, based on individual interviews and focus groups with 54 teenagers in New York City. A major obstacle was the belief that people should stop smoking forever. The youth had to cope with temptation, frequent and often i... | ['Adaptation, Psychological', 'Adolescent', 'Adolescent Behavior', 'Age Factors', 'Female', 'Humans', 'Interviews as Topic', 'Male', 'New York City', 'Qualitative Research', 'Risk Factors', 'Risk-Taking', 'Smoking', 'Smoking Cessation', 'Stress, Psychological'] | 17,582,023 | [['F01.058'], ['M01.060.057'], ['F01.145.022'], ['N05.715.350.075', 'N06.850.490.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.420', 'L01.399.250.520', 'N05.715.360.300.400', 'N06.850.520.308.420'], ['Z01.107.567.875.350.530.530', 'Z01.107.567.875.500.530.530', 'Z01.433.741'], ['H01.770.644.241.... | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Geographicals [Z]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 |
Transforming growth factor-1 promotes the transcriptional activation of plasminogen activator inhibitor type 1 in carcinoma-associated fibroblasts. | Carcinoma-associated fibroblasts (CAFs) play a pivotal role in promoting the growth, invasion and metastasis of tumor cells. However, to date little is known about the oncogenic mechanisms of CAFs. This study aimed to identify the microenvironmental factors involved in tumor developm... | ['Actins', 'Carcinoma', 'Cells, Cultured', 'Colorectal Neoplasms', 'Epidermal Growth Factor', 'Fibroblasts', 'Humans', 'Liver Neoplasms', 'Plasminogen Activator Inhibitor 1', 'Platelet-Derived Growth Factor', 'RNA, Messenger', 'Thy-1 Antigens', 'Transcriptional Activation', 'Transforming Growth Factor beta1', 'Up-Regul... | 22,895,748 | [['D05.750.078.730.250', 'D12.776.210.500.100', 'D12.776.220.525.255'], ['C04.557.470.200'], ['A11.251'], ['C04.588.274.476.411.307', 'C06.301.371.411.307', 'C06.405.249.411.307', 'C06.405.469.158.356', 'C06.405.469.491.307', 'C06.405.469.860.180'], ['D06.472.317.350', 'D12.644.276.382.500', 'D12.776.467.382.500', 'D23... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Tissue and regional distribution of activity of phenylmethylsulfonyl fluoride inhibited carboxypeptidase and other carboxypeptidases in rats]. | Phenylmethylsulfonyl fluoride (PMSF)-inhibited carboxypeptidase (CP) is recently described exopeptidase, that cleaved arginine residues from C-terminal of enkephalin synthetic analogs. The highest enzyme activity was found in the adrenal gland and 40% lower one was revealed in the pituitary gland. A 2.5-fold lower than... | ['Adrenal Glands', 'Animals', 'Brain', 'Carboxypeptidase B', 'Carboxypeptidase H', 'Carboxypeptidases', 'Hydrolysis', 'Kidney', 'Kinetics', 'Lysosomes', 'Male', 'Organ Specificity', 'Phenylmethylsulfonyl Fluoride', 'Pituitary Gland', 'Protease Inhibitors', 'Rats', 'Spleen'] | 9,505,357 | [['A06.300.071'], ['B01.050'], ['A08.186.211'], ['D08.811.277.656.350.245.083', 'D08.811.277.656.350.555.200', 'D08.811.277.656.675.555.200', 'D08.811.277.656.837.061'], ['D08.811.277.656.350.245.167', 'D08.811.277.656.350.555.250', 'D08.811.277.656.675.555.250', 'D08.811.277.656.837.124'], ['D08.811.277.656.350.245'],... | ['Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[The disease factor of scapholunate dissociation]. | Scapholunate dissociation is the most common form of instability of the wrist. Its occurrence has been consistently attributed to previous trauma and is supposed to be treated by operation. In the present paper we show that chronic bilateral scapholunate dissociation without any symptoms is not rare. In two years we ac... | ['Carpal Bones', 'Humans', 'Joint Dislocations', 'Joint Instability', 'Lunate Bone', 'Radiography', 'Wrist Injuries'] | 1,553,564 | [['A02.835.232.087.319.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C05.550.518', 'C26.289'], ['C05.550.521'], ['A02.835.232.087.319.150.500'], ['E01.370.350.700'], ['C26.088.906']] | ['Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The experience with transcatheter ablation of supraventricular tachycardia in Puertorican adults. | Data of the transcatheter radio frequency ablations for patients with supraventricular tachycardia conducted in Puerto Rico is presented. One group includes the first 100 patients performed from September 1994 to March 1997 at the Cardiovascular Center of Puerto Rico and the Caribbean and the Second group includes 157 ... | ['Adult', 'Catheter Ablation', 'Humans', 'Puerto Rico', 'Tachycardia, Supraventricular', 'Treatment Outcome'] | 15,776,687 | [['M01.060.116'], ['E02.808.750.500', 'E04.014.760.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.107.084.900.750', 'Z01.639.880.750'], ['C14.280.067.845.880', 'C14.280.123.875.880', 'C23.550.073.845.880'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Amphioxus SYCP1: a case of retrogene replacement and co-option of regulatory elements adjacent to the ParaHox cluster. | Retrogenes are formed when an mRNA is reverse-transcribed and reinserted into the genome in a location unrelated to the original locus. If this retrocopy inserts into a transcriptionally favourable locus and is able to carry out its original function, it can, in rare cases, lead to retrogene replacement. This involves ... | ["5' Untranslated Regions", 'Amino Acid Sequence', 'Animals', 'DNA-Binding Proteins', 'Evolution, Molecular', 'Gene Expression Regulation, Developmental', 'Gonads', 'Homeodomain Proteins', 'Lancelets', 'Nuclear Proteins', 'Phylogeny', 'Promoter Regions, Genetic', 'Sequence Alignment', 'Synaptonemal Complex'] | 29,297,095 | [['D13.444.735.544.875.885', 'D13.444.735.790.878.885', 'G05.360.340.024.220.880.885', 'G05.360.340.024.340.137.910.885'], ['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D12.776.260'], ['G05.045.250', 'G16.075.250'], ['G05.308.310'], ['A05.360.576', 'A06.300.312'], ['D12.776.260.400'], ['B01.050.150.200.199... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Infrahepatic interruption of the inferior vena cava with portal continuation. | Asymptomatic infrahepatic interruption of the inferior vena cava with portal continuation is described. The diagnosis was established by ultrasound and confirmed by inferior cavography and computed tomography. Hemodynamic studies showed portal hypertension due to increased blood flow through the liver. | ['Adult', 'Humans', 'Hypertension, Portal', 'Male', 'Portal Vein', 'Tomography, X-Ray Computed', 'Ultrasonography', 'Vena Cava, Inferior'] | 3,881,797 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C06.552.494'], ['A07.015.908.670.567'], ['E01.370.350.350.810', 'E01.370.350.600.350.700.810', 'E01.370.350.700.700.810', 'E01.370.350.700.810.810', 'E01.370.350.825.810.810'], ['E01.370.350.850'], ['A07.015.908.949.648']] | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Fusarium fingernail infection responsive to fluconazole intermittent therapy. | A case of fingernail infection by Fusarium is presented. This nondermatophytic mold is an infrequent cause of onychomycosis, more typically involving the great toenail. Characteristic histologic features including the presence of hyphae and chlamydoconia are helpful in rapid diagnosis and selection of appropriate antif... | ['Adult', 'Antifungal Agents', 'Drug Administration Schedule', 'Female', 'Fluconazole', 'Fusarium', 'Hand Dermatoses', 'Humans', 'Onychomycosis'] | 10,879,301 | [['M01.060.116'], ['D27.505.954.122.136'], ['E02.319.283'], ['D03.383.129.799.450'], ['B01.300.381.366'], ['C17.800.338'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C01.150.703.302.720.550', 'C01.800.200.720.550', 'C17.800.529.550', 'C17.800.838.208.883.458']] | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
InSe Nanosheets for Efficient NIR-II-Responsive Drug Release. | Near-infrared-II (NIR-II) biowindow is appealing from the perspectives of larger maximum permissible exposure in comparison with the near-infrared-I biowindow, so the NIR-II-responsive drug-delivery nanoplatform is highly desirable. In this work, two-dimensional InSe nanosheets (InSe NSs) are modified with poly(ethylen... | ['Delayed-Action Preparations', 'Doxorubicin', 'Humans', 'Hyperthermia, Induced', 'MCF-7 Cells', 'Nanoparticles', 'Neoplasms', 'Phototherapy'] | 31,180,631 | [['D26.255.210', 'E02.319.300.253'], ['D02.455.426.559.847.562.050.200.175', 'D04.615.562.050.200.175', 'D09.408.051.059.200.175'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.565'], ['A11.251.210.190.630'], ['J01.637.512.600'], ['C04'], ['E02.774']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Group B streptococci colonization in pregnant women: risk factors and evaluation of the vaginal flora. | OBJECTIVE: To determine the prevalence of group B streptococci (GBS) in our population, and to assess the association between risk factors and vaginal flora with maternal rectovaginal colonization.METHOD: Samples were obtained from 405 patients between 35 and 37 weeks of gestation. Swabs from the vaginal and perianal r... | ['Adult', 'Brazil', 'Female', 'Humans', 'Logistic Models', 'Pregnancy', 'Pregnancy Complications, Infectious', 'Prospective Studies', 'Risk Factors', 'Streptococcal Infections', 'Streptococcus agalactiae', 'Vagina', 'Young Adult'] | 20,349,243 | [['M01.060.116'], ['Z01.107.757.176'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.525', 'E05.318.740.600.800.450', 'E05.318.740.750.450', 'E05.599.835.875', 'N05.715.360.750.530.480', 'N05.715.360.750.625.700.450', 'N05.715.360.750.695.470', 'N06.850.520.830.500.525', 'N06.850.520.830.600.800.45... | ['Named Groups [M]', 'Geographicals [Z]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Predicting protein phenotypes based on protein-protein interaction network. | BACKGROUND: Identifying associated phenotypes of proteins is a challenge of the modern genetics since the multifactorial trait often results from contributions of many proteins. Besides the high-through phenotype assays, the computational methods are alternative ways to identify the phenotypes of proteins.METHODOLOGY/P... | ['Databases, Protein', 'Phenotype', 'Protein Binding', 'Protein Interaction Mapping', 'Reproducibility of Results', 'Saccharomyces cerevisiae', 'Saccharomyces cerevisiae Proteins'] | 21,423,698 | [['L01.313.500.750.300.188.400.300.750', 'L01.313.500.750.300.188.400.325.710', 'L01.470.750.750.300.750', 'L01.470.750.750.325.710'], ['G05.695'], ['G02.111.679', 'G03.808'], ['E05.601.690'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['B01.300.107.795.785.800', 'B01.300.930.705.... | ['Information Science [L]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Slowed transcription and rapid messenger RNA turnover contribute to a decline in synthesis of ovine trophoblast protein-1 during in vitro culture. | Ovine trophoblast protein-1 (oTP-1) is produced in massive amounts by conceptuses during the Day-12-20-period of early pregnancy. The rate of production of oTP-1 declines during culture of conceptuses, however, suggesting a role for critical intrauterine factors for continued production. The present study was conducted... | ['Animals', 'Cells, Cultured', 'DNA', 'DNA Probes', 'Female', 'Half-Life', 'Immunoblotting', 'Interferon Type I', 'Nucleic Acid Hybridization', 'Pregnancy', 'Pregnancy Proteins', 'RNA, Messenger', 'Sheep', 'Time Factors', 'Transcription, Genetic', 'Tritium', 'Trophoblasts', 'Uridine'] | 1,878,440 | [['B01.050'], ['A11.251'], ['D13.444.308'], ['D13.444.600.223', 'D27.505.259.750.600.223', 'D27.720.470.530.600.223'], ['G01.910.405'], ['E05.478.566.320', 'E05.601.470.320'], ['D12.644.276.374.440.890', 'D12.776.467.374.440.890', 'D23.529.374.440.890'], ['E05.393.661', 'G02.111.611'], ['G08.686.784.769'], ['D12.776.78... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Hydrolytic function of Exo1 in mammalian mismatch repair. | Genetic and biochemical studies have previously implicated exonuclease 1 (Exo1) in yeast and mammalian mismatch repair, with results suggesting that function of the protein in the reaction depends on both its hydrolytic activity and its ability to interact with other components of the repair system. However, recent ana... | ['Animals', 'DNA Mismatch Repair', 'Exodeoxyribonucleases', 'Hydrolysis', 'Mice', 'Mutation'] | 24,829,455 | [['B01.050'], ['G02.111.222.220', 'G05.219.220'], ['D08.811.277.352.335.375', 'D08.811.277.352.365.290'], ['G02.380'], ['B01.050.150.900.649.313.992.635.505.500'], ['G05.365.590']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
CHIP/Stub1 regulates the Warburg effect by promoting degradation of PKM2 in ovarian carcinoma. | Tumor cells preferentially adopt aerobic glycolysis for their energy supply, a phenomenon known as the Warburg effect. It remains a matter of debate as to how the Warburg effect is regulated during tumor progression. Here, we show that CHIP (carboxyl terminus of Hsc70-interacting protein), a U-box E3 ligase, suppresses... | ['Animals', 'Carrier Proteins', 'Cell Line, Tumor', 'Down-Regulation', 'Female', 'Glycolysis', 'HEK293 Cells', 'Heterografts', 'Humans', 'Membrane Proteins', 'Mice', 'Mice, Inbred BALB C', 'Mice, Nude', 'Ovarian Neoplasms', 'Pyruvate Kinase', 'Signal Transduction', 'Thyroid Hormones', 'Ubiquitin-Protein Ligases'] | 28,346,425 | [['B01.050'], ['D12.776.157'], ['A11.251.210.190', 'A11.251.860.180'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['G02.111.158.750', 'G03.191.750', 'G03.295.436', 'G03.493.360'], ['A11.251.210.172.750', 'A11.436.334'], ['A01.941.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.543'], ['B01.050... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Complete mitochondrial genome of Hemisalanx brachyrostralis (Osteichthyes: Salangidae). | Hemisalanx brachyrostralis belonging to the family Salangidae is endemic to the Yangtze River. This species has been listed on the Chinese Red List because of the serious decrease in its resources. In this study, we analyzed the complete mtDNA (16588 bp long) of H. brachyrostralis. Overall base composition of the genom... | ['Animals', 'Base Composition', 'Base Sequence', 'China', 'DNA, Mitochondrial', 'Gene Order', 'Genetic Variation', 'Genome, Mitochondrial', 'Osmeriformes', 'Sequence Analysis, DNA'] | 24,892,489 | [['B01.050'], ['G02.111.080'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['Z01.252.474.164'], ['D13.444.308.283.225'], ['G05.340'], ['G05.365'], ['G05.360.340.360'], ['B01.050.150.900.493.595'], ['E05.393.760.700']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Geographicals [Z]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 |
Growth-rate dependence reveals design principles of plasmid copy number control. | Genetic circuits in bacteria are intimately coupled to the cellular growth rate as many parameters of gene expression are growth-rate dependent. Growth-rate dependence can be particularly pronounced for genes on plasmids; therefore the native regulatory systems of a plasmid such as its replication control system are ch... | ['Bacterial Proteins', 'Escherichia coli', 'Gene Dosage', 'Plasmids', 'Sequence Deletion'] | 21,647,376 | [['D12.776.097'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['G05.380.350'], ['G05.360.600'], ['G05.365.590.762', 'G05.558.800']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Measles virus phosphoprotein retains the nucleocapsid protein in the cytoplasm. | Measles virus (MV) proteins were efficiently expressed in COS and Vero cells from vectors based on the strong cytomegalovirus enhancer-promoter and the simian virus 40 origin of replication. When expressed alone, nucleocapsid protein (N) migrates predominantly into the nucleus whereas phosphoprotein (P) is located in t... | ['Animals', 'Base Sequence', 'Capsid', 'Cell Line', 'Cytomegalovirus', 'Cytoplasm', 'DNA Replication', 'DNA, Viral', 'Enhancer Elements, Genetic', 'Fluorescent Antibody Technique', 'Genetic Vectors', 'Measles virus', 'Molecular Sequence Data', 'Oligodeoxyribonucleotides', 'Phosphoproteins', 'Promoter Regions, Genetic',... | 1,656,588 | [['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A21.249.500.250'], ['A11.251.210'], ['B04.280.382.150.150'], ['A11.284.430.214'], ['G02.111.225', 'G05.226'], ['D13.444.308.568'], ['G02.111.570.080.689.330', 'G05.360.080.689.330', 'G05.360.340.024.340.137.750.249'], ['E01.370.225.500.607.512.2... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Trisomy of rat chromosome 1 associated with mesothelial cell transformation. | Identification of specific chromosomal aberrations in transformed mesothelial cells is an important step in elucidating the mechanism of transformation of these cells which are targets for occupational and environmental carcinogens, such as asbestos fibers. Cytogenetic analysis of normal rat mesothelial cell lines reve... | ['Animals', 'Cell Line', 'Cell Transformation, Neoplastic', 'Chromosomes', 'Epithelial Cells', 'Epithelium', 'Karyotyping', 'Mesothelioma', 'Pleura', 'Rats', 'Trisomy', 'Tumor Cells, Cultured'] | 1,855,220 | [['B01.050'], ['A11.251.210'], ['C04.697.098.500', 'C23.550.727.098.500'], ['A11.284.187', 'A11.284.430.106.279.345.190', 'G05.360.162'], ['A11.436'], ['A10.272'], ['E01.370.225.500.385.315', 'E05.200.500.385.315', 'E05.242.385.315', 'E05.393.285.475'], ['C04.557.470.035.510', 'C04.557.470.660.510'], ['A04.716', 'A10.6... | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytochrome b6/f complex as an indigenous photodynamic generator of singlet oxygen in thylakoid membranes. | Possible association of photodynamic sensitization by cytochrome b6/f complex (cyt b6/f) via singlet oxygen (1O2) mechanism with photoinhibition damage to photosystem II (PS II) was studied using such subthylakoid preparations as photosystem I (PS I) particles, PS II core complex and cyt b6/f from spinach leaves. Upon ... | ['Cytochrome b Group', 'Cytochrome b6f Complex', 'Oxygen', 'Photosynthetic Reaction Center Complex Proteins', 'Photosystem I Protein Complex', 'Photosystem II Protein Complex', 'Singlet Oxygen', 'Spinacia oleracea', 'Thylakoids'] | 10,649,897 | [['D08.244.187', 'D12.776.422.220.187'], ['D05.500.562.488.374', 'D08.811.600.710.374', 'D12.776.543.585.450.250.875.311', 'D12.776.543.930.500.374', 'D12.776.765.199.750.750.374'], ['D01.268.185.550', 'D01.362.670'], ['D05.500.562.488', 'D08.811.600.710', 'D12.776.543.930.500', 'D12.776.765.199.750.750'], ['D05.500.56... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A Novel Deep Learning Algorithm for the Automatic Detection of High-Grade Gliomas on T2-Weighted Magnetic Resonance Images: A Preliminary Machine Learning Study. | AIM: To propose a convolutional neural network (CNN) for the automatic detection of high-grade gliomas (HGGs) on T2-weighted magnetic resonance imaging (MRI) scans.MATERIAL AND METHODS: A total of 3580 images obtained from 179 individuals were used for training and validation. After random rotation and vertical flip, t... | ['Algorithms', 'Brain Neoplasms', 'Deep Learning', 'Glioma', 'Humans', 'Machine Learning', 'Magnetic Resonance Imaging', 'Neural Networks, Computer'] | 31,608,975 | [['G17.035', 'L01.224.050'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['G17.035.250.500.250', 'G17.485.500', 'L01.224.050.375.530.250', 'L01.224.050.375.605.500'], ['C04.557.465.625.600.380', 'C04.557.470.670.380', 'C04.557.580.625.600.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G17.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Stylicins, a new family of antimicrobial peptides from the Pacific blue shrimp Litopenaeus stylirostris. | The present study reports the characterization of Ls-Stylicin1, a novel antimicrobial peptide from the penaeid shrimp, Litopenaeus stylirostris. The predicted mature peptide of 82 residues is negatively charged (theoretical pI=5.0) and characterized by a proline-rich N-terminal region and a C-terminal region containing... | ['Amino Acid Sequence', 'Animals', 'Antimicrobial Cationic Peptides', 'Base Sequence', 'Biological Assay', 'DNA, Complementary', 'Electrophoresis, Polyacrylamide Gel', 'Hemocytes', 'Microbial Sensitivity Tests', 'Molecular Sequence Data', 'Pacific Ocean', 'Penaeidae', 'Protein Binding', 'Protein Transport', 'Recombinan... | 20,061,030 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D12.644.050', 'D12.776.543.695.054'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.091'], ['D13.444.308.497.220', 'D13.444.600.223.500', 'D27.720.470.530.600.223.260'], ['E05.196.401.402', 'E05.301.300.319'], ['A11.118.480', 'A15.145.229.48... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Geographicals [Z]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 |
Patterns of Reproductive Isolation in Eucalyptus-A Phylogenetic Perspective. | We assess phylogenetic patterns of hybridization in the speciose, ecologically and economically important genus Eucalyptus, in order to better understand the evolution of reproductive isolation. Eucalyptus globulus pollen was applied to 99 eucalypt species, mainly from the large commercially important subgenus, Symphyo... | ['Confidence Intervals', 'Crosses, Genetic', 'Eucalyptus', 'Hybridization, Genetic', 'Models, Genetic', 'Phylogeny', 'Reproductive Isolation', 'Species Specificity'] | 25,777,461 | [['E05.318.740.275', 'N05.715.360.750.220', 'N06.850.520.830.275'], ['E05.393.281'], ['B01.650.940.800.575.912.250.773.366'], ['E05.820.150.390', 'G05.090.390'], ['E05.599.395.397'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['G05.045.675', 'G16.075.802'], ['G16.824']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Characterization of a peptide from skin secretions of male specimens of the frog, Leptodactylus fallax that stimulates aggression in male frogs. | During the breeding season of the mountain chicken frog Leptodactylus fallax, fighting between males results in the emergence of dominant animals that subsequently attract females to nesting sites. A peptide, termed Leptodactylus aggression-stimulating peptide (LASP), was isolated from norepinephrine-stimulated skin se... | ['Aggression', 'Amino Acid Sequence', 'Animals', 'Anura', 'Chromatography, High Pressure Liquid', 'Female', 'Male', 'Peptides', 'Sexual Behavior, Animal', 'Skin'] | 15,752,573 | [['F01.145.126.125', 'F01.145.813.045'], ['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['B01.050.150.900.090.180'], ['E05.196.181.400.300'], ['D12.644'], ['F01.145.113.252.748'], ['A17.815']] | ['Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
[Profiles of lipid oxidation by a free radical mechanism in patients with bacterial sore throat]. | Properties of prooxidative and antioxidative systems were investigated in 74 patients with bacterial sore throat. The results suggest a noticeable unidirectional change of the free radical status with marked amplification of prooxidative and attenuation of antioxidative activities depending on the clinical form of the ... | ['Adolescent', 'Adult', 'Female', 'Free Radical Scavengers', 'Humans', 'Lipid Peroxidation', 'Male', 'Malondialdehyde', 'Middle Aged', 'Pharyngitis', 'Respiratory Mucosa', 'Severity of Illness Index', 'Young Adult'] | 19,008,840 | [['M01.060.057'], ['M01.060.116'], ['D27.505.519.217.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.111.515', 'G03.295.531.587'], ['D02.047.700'], ['M01.060.116.630'], ['C01.748.561', 'C07.550.781', 'C08.730.561', 'C09.775.649'], ['A04.760', 'A10.615.550.760'], ['E05.318.308.980.438.475.456.500', 'N05.71... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Inhibition of activator protein 1 signaling abrogates transforming growth factor â-mediated activation of fibroblasts and prevents experimental fibrosis. | OBJECTIVE: To investigate whether c-Jun and c-Fos contribute to the pathologic activation of fibroblasts in systemic sclerosis (SSc) and to evaluate the antifibrotic potential of selective activator protein 1 (AP-1) inhibition.METHODS: Expression of c-Jun and c-Fos was determined by real-time polymerase chain reaction ... | ['Animals', 'Benzophenones', 'Bleomycin', 'Cells, Cultured', 'Collagen', 'Disease Models, Animal', 'Female', 'Fibroblasts', 'Fibrosis', 'Gene Expression', 'Humans', 'Isoxazoles', 'JNK Mitogen-Activated Protein Kinases', 'Male', 'Mice', 'Proto-Oncogene Proteins c-fos', 'RNA, Small Interfering', 'Scleroderma, Systemic', ... | 22,139,817 | [['B01.050'], ['D02.455.426.559.389.134', 'D02.522.223'], ['D09.400.420.110', 'D12.644.233.110'], ['A11.251'], ['D05.750.078.280', 'D12.776.860.300.250'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['A11.329.228'], ['C23.550.355'], ['G05.297'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.383.129.385'], [... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Domestic animals and epidemiology of visceral leishmaniasis, Nepal. | On the Indian subcontinent, visceral leishmaniasis (VL) is considered an anthroponosis. To determine possible reasons for its persistence during interepidemic periods, we mapped Leishmania infections among healthy persons and animals in an area of active VL transmission in Nepal. During 4 months (September 2007-Februar... | ['Animals', 'Buffaloes', 'Cattle', 'Cluster Analysis', 'Disease Reservoirs', 'Goat Diseases', 'Goats', 'Humans', 'Leishmaniasis, Visceral', 'Nepal', 'Population Surveillance', 'Prevalence'] | 20,113,552 | [['B01.050'], ['B01.050.150.900.649.313.500.380.135'], ['B01.050.150.900.649.313.500.380.271'], ['E05.318.740.250', 'N05.715.360.750.200', 'N06.850.520.830.250'], ['N06.850.520.203.250'], ['C22.405'], ['B01.050.150.900.649.313.500.380.513'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C01.610.752.300.500.510', '... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
[A laboratory multipositional skull base holder]. | Authors present an original multipositional holder for skull base cadaveric specimens, either formalin or fresh. It is constructed to be fixated for standard neurosurgical operating table, devoted for laboratory micro neurosurgical dissection and suitable for simulation operation on patient. The holder is made of solid... | ['Cadaver', 'Dissection', 'Humans', 'Neurosurgery', 'Skull Base'] | 18,510,072 | [['C23.550.260.224'], ['E01.370.225.998.221', 'E04.221', 'E05.200.998.221'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H02.403.810.425'], ['A01.456.830', 'A02.835.232.781.750']] | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Rigor in electronic health record knowledge representation: Lessons learned from a SNOMED CT clinical content encoding exercise. | UNLABELLED: Rigor in clinical knowledge representation is necessary foundation for meaningful interoperability, exchange and reuse of electronic health record (EHR) data. It is critical for clinicians to understand principles and implications of using clinical standards for knowledge representation within EHRs.PURPOSE:... | ['Clinical Coding', 'Electronic Health Records', 'Humans', 'Students, Nursing', 'Systematized Nomenclature of Medicine', 'User-Computer Interface'] | 25,325,887 | [['N04.452.758.708.200.400.500', 'N04.452.859.564.274', 'N05.715.360.300.715.500.249', 'N06.850.520.308.940.968.249'], ['E05.318.308.940.968.625.500', 'N04.452.859.564.650.125', 'N05.715.360.300.715.500.530.250', 'N06.850.520.308.940.968.625.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.848.769.685'], [... | ['Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Chromosomal mapping of the GFP-LC3 transgene in GFP-LC3 mice. | GFP-LC3 mice are widely used to monitor autophagy. Here, we report chromosomal mapping of the GFP.LC3 transgene in this mouse model. The transgene was located in a very distal region of chromosome 2, immediately upstream of a putative open reading frame that is thought to be a part of a pseudogene. With this informatio... | ['Animals', 'Autophagy', 'Chromosome Mapping', 'Female', 'Green Fluorescent Proteins', 'Male', 'Mice', 'Mice, Transgenic', 'Microtubule-Associated Proteins', 'Phenotype', 'Recombinant Fusion Proteins', 'Transgenes'] | 17,786,029 | [['B01.050'], ['G04.011'], ['E05.393.183'], ['D12.776.532.265'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.136.500', 'B01.050.150.900.649.313.992.635.505.500.800'], ['D12.776.220.600.450', 'D12.776.631.560'], ['G05.695'], ['D12.776.828.300'], ['G05.360.340.024.340.825']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Initial treatment choice in depression: impact on medical expenditures. | OBJECTIVE: The purpose of this study was to examine the economic outcomes associated with initial treatment choice following a diagnosis of depression.METHODS: Insurance claims data were used to classify patients into one of 4 treatment cohorts: no therapy, psychotherapy, drug therapy and combination therapy. Potential... | ['Antidepressive Agents', 'Cohort Studies', 'Combined Modality Therapy', 'Databases, Factual', 'Depressive Disorder', 'Health Care Costs', 'Humans', 'Insurance Claim Review', 'Logistic Models', 'Models, Econometric', 'Psychotherapy'] | 10,947,492 | [['D27.505.954.427.700.122'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E02.186'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['F03.600.300'], ['N03.219.151.400', 'N05.300.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.219.521.576.215'], ['E05.318.740.500.5... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Information Science [L]', 'Psychiatry and Psychology [F]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Determinants of donor platelet variability when testing for heparin-induced thrombocytopenia. | Heparin-induced thrombocytopenia is a common immune-mediated drug reaction that can be complicated by life-threatening arterial thrombosis. The diagnosis can be confirmed by demonstrating heparin-dependent release of radiolabeled serotonin from washed normal platelets in the presence of patient serum. However, certain ... | ['Blood Donors', 'Blood Platelets', 'Heparin', 'Humans', 'Platelet Activation', 'Receptors, Fc', 'Serotonin', 'Thrombocytopenia'] | 1,517,683 | [['M01.898.313'], ['A11.118.188', 'A15.145.229.188'], ['D09.698.373.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G09.188.390.600'], ['D12.776.543.750.705.871'], ['D02.092.211.215.801.852', 'D03.633.100.473.914.814', 'D23.469.050.650'], ['C15.378.140.855']] | ['Named Groups [M]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Torquability of microcatheter guidewires: the resulting torsional moment. | Guidewires for microcatheters used for the subselective catheterization of small vessels must meet high quality requirements in regard to handling, steerability, radiopacity and physical properties. The aim of this paper is to classify one of the factors that determine the physical and mechanical parameters of a number... | ['Algorithms', 'Alloys', 'Catheterization, Peripheral', 'Equipment Design', 'Humans', 'Materials Testing', 'Micromanipulation', 'Nickel', 'Platinum', 'Pliability', 'Rotation', 'Stainless Steel', 'Stress, Mechanical', 'Surface Properties', 'Tensile Strength', 'Titanium', 'Torque'] | 10,950,205 | [['G17.035', 'L01.224.050'], ['D01.552.033', 'D25.058', 'J01.637.051.058'], ['E02.148.224', 'E04.100.814.529.937', 'E04.502.382.937', 'E05.157.375'], ['E05.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.570'], ['E05.591'], ['D01.268.556.607', 'D01.268.956.625', 'D01.552.544.607'], ['D01.268.556.690', 'D0... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Preoperative Anxiety in Patients With Myasthenia Gravis and Risk for Myasthenic Crisis After Extended Transsternal Thymectomy: A CONSORT Study. | A thymectomy can ameliorate the symptoms of myasthenia gravis (MG) and prevent the progression of ocular MG (OMG) to generalized MG (GMG). However, postoperative myasthenic crisis (POMC) is a serious post-thymectomy complication. Preoperative anxiety (POA) is common but typically neglected in MG patients. The associati... | ['Adolescent', 'Adult', 'Anxiety', 'China', 'Cholinesterase Inhibitors', 'Disease Progression', 'Dose-Response Relationship, Drug', 'Female', 'Humans', 'Male', 'Middle Aged', 'Myasthenia Gravis', 'Pneumonia', 'Postoperative Complications', 'Pyridostigmine Bromide', 'Retrospective Studies', 'Risk Assessment', 'Risk Fact... | 26,962,777 | [['M01.060.057'], ['M01.060.116'], ['F01.470.132'], ['Z01.252.474.164'], ['D27.505.519.389.275', 'D27.505.519.625.120.300', 'D27.505.696.577.120.300'], ['C23.550.291.656'], ['G07.690.773.875', 'G07.690.936.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C04.588.614.550.500', 'C04.730.856.... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
The XXXXY chromosome anomaly: report of three new cases and review of 30 cases from the literature. | The majority of abnormal sex chromosome complexes in the male have been considered to be variants of Klinefelter's syndrome but an exception should probably be made in the case of the XXXXY individual who has distinctive phenotypic features. Clinical, radiological and cytological data on three new cases of XXXXY syndro... | ['Adult', 'Bone and Bones', 'Child', 'Chromosome Aberrations', 'Chromosome Disorders', 'Diagnosis, Differential', 'Down Syndrome', 'Elbow', 'Facial Expression', 'Fingers', 'Humans', 'Intellectual Disability', 'Klinefelter Syndrome', 'Male', 'Radiography', 'Wrist'] | 4,222,822 | [['M01.060.116'], ['A02.835.232', 'A10.165.265'], ['M01.060.406'], ['C23.550.210', 'G05.365.590.175'], ['C16.131.260', 'C16.320.180'], ['E01.171'], ['C10.597.606.360.220', 'C16.131.077.327', 'C16.131.260.260', 'C16.320.180.260'], ['A01.378.800.420'], ['E01.370.600.225', 'F01.145.209.530.385'], ['A01.378.800.667.430'], ... | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Does kin selection influence fostering behaviour in Antarctic fur seals (Arctocephalus gazella)? | A recent observation that female Antarctic fur seals foster pups born to related females raises the fascinating possibility that kin selection may promote altruistic behaviour even on a crowded breeding beach, where individual interactions are frequent and complex. However, the use of genetic markers to identify small ... | ['Altruism', 'Animals', 'Atlantic Islands', 'Female', 'Fur Seals', 'Genotype', 'Maternal Behavior', 'Microsatellite Repeats', 'Research Design', 'Selection, Genetic'] | 16,191,611 | [['F01.145.813.090'], ['B01.050'], ['Z01.639.040'], ['B01.050.150.900.649.313.750.250.288'], ['G05.380'], ['F01.829.263.370.215'], ['G02.111.570.080.708.800.500', 'G05.360.080.708.800.500', 'G05.360.340.024.850.500'], ['E05.581.500', 'H01.770.644.728'], ['G05.783']] | ['Psychiatry and Psychology [F]', 'Organisms [B]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 |
Chiral, cross-conjugated isopolydiacetylenes. | A series of chiral, monodisperse enyne oligomers (isopolydiacetylenes) based on a 1,1-binaphthyl core has been synthesized and characterized spectroscopically. | ['Alkynes', 'Circular Dichroism', 'Molecular Structure', 'Organosilicon Compounds', 'Polyacetylene Polymer', 'Polymers', 'Polyynes', 'Sensitivity and Specificity', 'Spectrophotometry, Ultraviolet', 'Stereoisomerism'] | 17,047,786 | [['D02.455.326.397'], ['E05.196.867.151'], ['G02.111.570', 'G02.466'], ['D02.756'], ['D02.455.326.271.665.515', 'D05.750.223', 'D25.720.719', 'J01.637.051.720.719'], ['D05.750', 'D25.720', 'J01.637.051.720'], ['D02.455.326.397.680'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700', 'N05.715.360.... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Localized attentional interference reflects competition for reentrant processing. | Visual performance is compromised when attention is divided between objects that are near one another in the visual field. It has been postulated that this effect, termed localized attentional interference (LAI), reflects competition between visual-object representations for the control of cortical neural responses. To... | ['Attention', 'Color Perception', 'Cues', 'Discrimination Learning', 'Female', 'Humans', 'Male', 'Orientation', 'Pattern Recognition, Visual', 'Perceptual Masking', 'Visual Fields', 'Young Adult'] | 19,145,019 | [['F02.830.104.214'], ['F02.463.593.932.217'], ['F02.463.425.234'], ['F02.463.425.280'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.058.577', 'F02.830.606'], ['F02.463.593.524.500', 'F02.463.593.932.622'], ['F02.463.593.071.594', 'F02.463.593.932.733', 'G07.888.125.594'], ['F02.463.593.932.934', 'G14.950'],... | ['Psychiatry and Psychology [F]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Named Groups [M]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Knowledge and attitude of healthcare workers about Middle East Respiratory Syndrome in multispecialty hospitals of Qassim, Saudi Arabia. | BACKGROUND: With the increase in prevalence of Middle East Respiratory Syndrome (MERS), healthcare workers (HCWs) are at risk of acquiring and subsequently transmitting this lethal virus. In view of this, HCWs were evaluated for their knowledge of and attitude towards MERS in Saudi Arabia.METHODS: A cross sectional stu... | ['Adult', 'Coronavirus Infections', 'Cross-Sectional Studies', 'Female', 'Health Knowledge, Attitudes, Practice', 'Health Personnel', 'Hospitals', 'Humans', 'Infection Control', 'Male', 'Middle Aged', 'Saudi Arabia', 'Sex Factors'] | 25,510,239 | [['M01.060.116'], ['C01.925.782.600.550.200'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['F01.100.150.500', 'N05.300.150.410'], ['M01.526.485', 'N02.360'], ['N02.278.421'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N06.850.780.200.450'], ['M01.060.116.630'], ['Z01.252.245.... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Effect of melatonin implantation on the seasonal variation of FSH secretion in the male blue fox (Alopex lagopus). | A heterologous radioimmunoassay system developed for the sheep was shown to measure FSH in the plasma of the blue fox. FSH concentrations throughout the year showed a circannual rhythm with the highest values (61.6 +/- 14.8 ng/ml) occurring shortly before or at the onset of the mating season, a pattern similar to that ... | ['Animals', 'Drug Implants', 'Follicle Stimulating Hormone', 'Foxes', 'Gonadotropin-Releasing Hormone', 'Male', 'Melatonin', 'Pituitary Gland', 'Prolactin', 'Radioimmunoassay', 'Seasons', 'Testis'] | 3,135,390 | [['B01.050'], ['D26.255.210.315'], ['D06.472.699.322.576.288', 'D06.472.699.631.525.343.288', 'D12.644.548.691.525.343.288'], ['B01.050.150.900.649.313.750.250.216.250'], ['D06.472.699.327.740.320', 'D12.644.400.400.740.320', 'D12.644.456.460', 'D12.644.548.365.740.320', 'D12.776.631.650.405.740.320'], ['D03.633.100.47... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Risk factors for peripartum hysterectomy following uterine rupture. | OBJECTIVE: To investigate risk factors for hysterectomy following uterine rupture.METHODS: A population-based study comparing all uterine ruptures with and without hysterectomy between 1988 and 2011 was conducted. Stratified analysis was performed using a multiple logistic regression analysis.RESULTS: Peripartum hyster... | ['Adult', 'Female', 'Humans', 'Hysterectomy', 'Israel', 'Peripartum Period', 'Pregnancy', 'Retrospective Studies', 'Risk Factors', 'Uterine Rupture'] | 23,356,737 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.950.300.399'], ['Z01.252.245.500.375'], ['G08.686.701'], ['G08.686.784.769'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.520.450.500.500.500', 'N06.850.520.450.500.... | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Acoustically active lipospheres containing paclitaxel: a new therapeutic ultrasound contrast agent. | RATIONALE AND OBJECTIVES: Paclitaxel-carrying lipospheres (MRX-552) were developed and evaluated as a new ultrasound contrast agent for chemotherapeutic drug delivery.METHODS: Paclitaxel was suspended in soybean oil and added to an aqueous suspension of phospholipids in vials. The headspace of the vials was replaced wi... | ['Animals', 'Contrast Media', 'Drug Carriers', 'Drug Evaluation, Preclinical', 'HeLa Cells', 'Humans', 'Liposomes', 'Male', 'Mice', 'Mice, Inbred BALB C', 'Microspheres', 'Paclitaxel', 'Particle Size', 'Phantoms, Imaging', 'Sonication', 'Time Factors', 'Ultrasonography'] | 9,851,823 | [['B01.050'], ['D27.505.259.500', 'D27.720.259'], ['D26.255.260', 'E02.319.300.380'], ['E05.290.750', 'E05.337.550'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D25.479.517', 'D26.255.260.517', 'J01.637.051.479.517', 'J01.637.087.500.517'], ['B01.05... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Absorbance and EEM fluorescence of wastewater: Effects of filters, storage conditions, and chlorination. | Aim of this study was to delineate sample handling procedures for accurate fluorescence and UV absorbance measurements of wastewater organic matter. Investigations were performed using different wastewater qualities, including primary, secondary and tertiary wastewater effluents, and a wastewater-impacted surface water... | ['Disinfection', 'Filtration', 'Fluorescence', 'Halogenation', 'Humic Substances', 'Spectrometry, Fluorescence', 'Waste Disposal, Fluid', 'Waste Water', 'Water Pollutants, Chemical', 'Water Purification', 'Water Quality'] | 31,756,656 | [['N06.850.780.200.450.850.375'], ['E05.196.454', 'G01.280', 'G02.263'], ['G01.358.500.505.650.665.500', 'G01.590.540.665.500'], ['G02.111.323', 'G03.360'], ['D02.241.444', 'D02.455.426.559.389.657.377', 'D20.721.500'], ['E05.196.712.516.600.676', 'E05.196.867.726'], ['N06.850.780.200.800.800.890', 'N06.850.860.510.900... | ['Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[Choroidal angioarchitectonics and colorimetric scanning]. | The procedure proposed by the authors for colorimetric layer scanning of the fundus of the eye is able not only to identify choroidal capillaries as a uniform system, but also to enhance the accuracy of diagnosis and to increase the volume of findings, by analyzing the digital images of the structures of the eye ground... | ['Adult', 'Choroid', 'Humans', 'Myopia', 'Ophthalmoscopy', 'Reproducibility of Results', 'Retina'] | 17,087,024 | [['M01.060.116'], ['A09.371.894.223'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C11.744.636'], ['E01.370.380.560'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['A09.371.729']] | ['Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Isolation and characterization of a polygalacturonase gene highly expressed in Brassica napus pollen. | A cDNA clone, Sta 44-4, corresponding to a mRNA highly expressed in Brassica napus cv. Westar stamens, was isolated by differential screening and characterized. Northern blot and in situ analyses demonstrated that Sta 44-4 is synthesized in pollen beginning at the late uninucleate stage and reaches a maximum in trinucl... | ['Amino Acid Sequence', 'Base Sequence', 'Brassica', 'Cloning, Molecular', 'DNA, Complementary', 'Gene Expression', 'Genes, Plant', 'In Situ Hybridization', 'Molecular Sequence Data', 'Pollen', 'Polygalacturonase', 'RNA, Messenger'] | 8,292,791 | [['G02.111.570.060', 'L01.453.245.667.060'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['B01.650.940.800.575.912.250.157.200'], ['E05.393.220'], ['D13.444.308.497.220', 'D13.444.600.223.500', 'D27.720.470.530.600.223.260'], ['G05.297'], ['G05.360.340.024.340.393', 'G05.360.340.365.500'], ['E01.370.225.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Induction of MRP1 and gamma-glutamylcysteine synthetase gene expression by interleukin 1beta is mediated by nitric oxide-related signalings in human colorectal cancer cells. | Treatment of human colorectal cancer cells HT29 with interleukin 1beta (IL-1beta) induces expression of the multidrug resistance protein (MRP1) gene encoding the ATP-dependent glutathione S-conjugate export (GS-X) pump and the gamma-glutamylcysteine synthetase (gamma-GCSh) gene encoding heavy (catalytic) subunit of gam... | ['ATP-Binding Cassette Transporters', 'Ceramides', 'Colorectal Neoplasms', 'Gene Expression Regulation', 'Glutamate-Cysteine Ligase', 'Humans', 'Interleukin-1', 'Multidrug Resistance-Associated Proteins', 'Nitric Oxide', 'Nitric Oxide Donors', 'Nitric Oxide Synthase', 'Nitric Oxide Synthase Type II', 'RNA, Messenger', ... | 11,025,451 | [['D12.776.157.530.100', 'D12.776.395.550.020', 'D12.776.543.550.192', 'D12.776.543.585.100'], ['D02.065.313', 'D09.400.410.420.525.200', 'D10.390.470.675.200', 'D10.570.877.360.612.200'], ['C04.588.274.476.411.307', 'C06.301.371.411.307', 'C06.405.249.411.307', 'C06.405.469.158.356', 'C06.405.469.491.307', 'C06.405.46... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
3-D flexible nano-textured high-density microelectrode arrays for high-performance neuro-monitoring and neuro-stimulation. | We introduce a new 3-D flexible microelectrode array for high performance electrographic neural signal recording and stimulation. The microelectrode architecture maximizes the number of channels on each shank and minimizes its footprint. The electrode was implemented on flexible polyimide substrate using microfabricati... | ['Algorithms', 'Animals', 'Electric Stimulation', 'Equipment Design', 'Microelectrodes', 'Monitoring, Physiologic', 'Nanotechnology', 'Rats', 'Rats, Wistar', 'Signal-To-Noise Ratio', 'Surface Properties'] | 24,876,130 | [['G17.035', 'L01.224.050'], ['B01.050'], ['E05.723.402'], ['E05.320'], ['E07.305.250.500'], ['E01.370.520'], ['H01.603', 'J01.897.520.600'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.900'], ['E05.318.370.800.875', 'E05.318.740.872.875', 'G17.800.500', 'N05.715.360.325.700.8... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 |
Overexpressing MhNPR1 in transgenic Fuji apples enhances resistance to apple powdery mildew. | Fuji is susceptible to fungal diseases like apple powdery mildew. Non-expressor of pathogenesis-related gene 1 (NPR1) plays a key role in regulating salicylic acid (SA)-mediated systemic acquired resistance (SAR). Previous studies show that overexpressing the Malus hupehensis-derived NPR1 (MhNPR1) gene in tobacco induc... | ['Gene Expression', 'Gene Expression Regulation, Plant', 'Malus', 'Phenotype', 'Plant Diseases', 'Plant Proteins', 'Plants, Genetically Modified'] | 22,539,187 | [['G05.297'], ['G05.308.375'], ['B01.650.940.800.575.912.250.859.937.500.444'], ['G05.695'], ['G15.610'], ['D12.776.765'], ['B01.650.520', 'B05.620.600']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondrial DNA diversity in the pea aphid Acyrthosiphon pisum. | The pea aphid Acyrthosiphon pisum has been established in North America for at least a century and occurs on a broad range of host plants. Despite its importance as a crop pest, there is little understanding of the genetic structure of its populations or the extent of genetic divergence associated with different host p... | ['Animals', 'Aphids', 'Base Sequence', 'Clone Cells', 'DNA Primers', 'DNA, Mitochondrial', 'Fabaceae', 'Genes, Insect', 'Genetic Variation', 'Medicago sativa', 'Molecular Sequence Data', 'Plants, Medicinal', 'Polymerase Chain Reaction', 'Polymorphism, Restriction Fragment Length', 'Restriction Mapping'] | 8,001,815 | [['B01.050'], ['B01.050.500.131.617.412.165'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A11.251.353'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['D13.444.308.283.225'], ['B01.650.940.800.575.912.250.401'], ['G05.360.340.024.340.340', 'G05.360.340.357.500'], ['G05.365'], ['B01.650.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Compartmentalization of human chorionic gonadotrophin sensitivity and luteinizing hormone receptor mRNA in different subtypes of the human corpus luteum. | The relationship was investigated between different ultrasonographically defined subtypes of the human corpus luteum and progesterone production. Twenty-one women in the mid-luteal phase who underwent laparotomy for benign uterine conditions volunteered for this study. The corpus luteum was identified by preoperative u... | ['Adult', 'Corpus Luteum', 'Female', 'Humans', 'Hysterectomy', 'In Situ Hybridization', 'In Vitro Techniques', 'Middle Aged', 'Progesterone', 'RNA, Messenger', 'Receptors, LH', 'Sensitivity and Specificity', 'Time Factors', 'Ultrasonography'] | 9,194,662 | [['M01.060.116'], ['A05.360.319.114.630.278', 'A06.300.312.497.278'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.950.300.399'], ['E01.370.225.500.620.670.325', 'E01.370.225.750.600.670.325', 'E05.200.500.620.670.325', 'E05.200.750.600.670.325', 'E05.393.661.475'], ['E05.481'], ['M01.060.116.630'], ['D04.210... | ['Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Genetic Analysis for Fruit Phenolics Content, Flesh Color, and Browning Related Traits in Eggplant (Solanum melongena | Eggplant varieties rich in bioactive chlorogenic acid along with less browning are preferred by consumers. Therefore, genetics of fruit phenolics, fruit flesh colour, and browning related traits were studied in the genotypes of eggplant, comprising of nine cultivated varieties and one accession of eggplant's primary ge... | ['Chlorogenic Acid', 'Evolution, Molecular', 'Fruit', 'Genetic Association Studies', 'Genetic Variation', 'Hybridization, Genetic', 'Phenols', 'Phytochemicals', 'Pigmentation', 'Polymorphism, Single Nucleotide', 'Quantitative Trait, Heritable', 'Solanum melongena'] | 31,248,080 | [['D02.241.223.200.185', 'D02.241.223.268.220'], ['G05.045.250', 'G16.075.250'], ['A18.024.500', 'G07.203.300.562', 'J02.500.562'], ['E05.393.385'], ['G05.365'], ['E05.820.150.390', 'G05.090.390'], ['D02.455.426.559.389.657'], ['D23.704'], ['E01.370.600.620', 'G16.690'], ['G05.365.795.598'], ['G05.420.720'], ['B01.650.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
[Gefitinib in the treatment of advanced non-small cell lung cancer]. | OBJECTIVE: To investigate the efficacy, time to progression, survival time and toxicity of epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor Gefitinib (Iressa), a target therapy agent, in the treatment of advanced non-small cell lung cancer (NSCLC), and to analyze the factors affecting the efficacy and ... | ['Adult', 'Aged', 'Antineoplastic Agents', 'Bone Neoplasms', 'Brain Neoplasms', 'Carcinoma, Non-Small-Cell Lung', 'Disease Progression', 'Exanthema', 'Female', 'Follow-Up Studies', 'Gefitinib', 'Humans', 'Lung Neoplasms', 'Male', 'Middle Aged', 'Neoplasm Staging', 'Quinazolines', 'Survival Analysis', 'Treatment Outcome... | 17,152,500 | [['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.248'], ['C04.588.149', 'C05.116.231'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['C04.588.894.797.520.109.220.249', 'C08.381.540.140.500', 'C08.785.520.100.220.500'], ['C23.550.291.656'], ['C17.800.257'], ['E05.318.372.500.750.249', 'N05.715.360... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Risk factors for acquisition of carbapenem-resistance during treatment with carbapenem in the intensive care unit: a prospective study. | The emergence of carbapenemases in gram-negative aerobes is worrying. The aim of this prospective study was to estimate the incidence of acquisition of carbapenem-resistance during treatment in ICU and to identify the risk factors. This was a prospective, observational, cohort study. This study was conducted at intensi... | ['Aged', 'Anti-Bacterial Agents', 'Bacteria', 'Bacterial Infections', 'Carbapenems', 'Drug Resistance, Bacterial', 'Female', 'Hospitals, University', 'Humans', 'Intensive Care Units', 'Male', 'Middle Aged', 'Prospective Studies', 'Risk Factors'] | 31,482,416 | [['M01.060.116.100'], ['D27.505.954.122.085'], ['B03'], ['C01.150.252'], ['D02.065.589.099.124', 'D03.633.100.300.124'], ['G06.099.225', 'G06.225.347', 'G07.690.773.984.269.347'], ['N02.278.020.300.310', 'N02.278.421.639.725'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N02.278.388.493'], ['M01.060.116.630'], [... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Lipoprotein lipase, hepatic lipase, and carnitine in premature infants. | Twenty six preterm infants were studied at the age of 2, 7, and 26 days. The activities of lipoprotein and hepatic lipase in plasma taken 15 minutes after a heparin bolus of 100 IU/kg had been given and the concentrations of carnitine in serum and urine were measured. The mean gestational age was 31 weeks (range 26-35 ... | ['Age Factors', 'Birth Weight', 'Carnitine', 'Female', 'Gestational Age', 'Humans', 'Infant, Newborn', 'Infant, Premature', 'Isoenzymes', 'Lipase', 'Lipoprotein Lipase', 'Liver', 'Male'] | 3,348,661 | [['N05.715.350.075', 'N06.850.490.250'], ['C23.888.144.186', 'E01.370.600.115.100.160.120.186', 'E05.041.124.160.750.149', 'G07.100.100.160.120.186', 'G07.345.249.314.120.186'], ['D02.092.877.883.099'], ['G07.345.500.325.235.968', 'G08.686.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['M... | ['Health Care [N]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Named Groups [M]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Prognostic significance of the new placental proteins in trophoblastic disease. | Circulating levels of four specific placental proteins, human chorionic gonadotrophin (hCG), Schwangerschafts protein 1 (SP1), placental protein 5 (PP5) and pregnancy-associated plasma protein A (PAPP-A), were measured in 31 patients with hydatidiform mole before treatment. Seven patients subsequently developed clinica... | ['Adult', 'Choriocarcinoma', 'Chorionic Gonadotropin', 'Female', 'Glycoproteins', 'Humans', 'Hydatidiform Mole', 'Lung Neoplasms', 'Pregnancy', 'Pregnancy Proteins', 'Pregnancy-Associated Plasma Protein-A', 'Pregnancy-Specific beta 1-Glycoproteins', 'Prognosis', 'Uterine Neoplasms'] | 6,189,512 | [['M01.060.116'], ['C04.557.465.955.207', 'C04.557.470.200.025.455', 'C04.850.908.208', 'C13.703.720.949.208'], ['D06.472.699.322.326', 'D06.472.699.649.367', 'D12.644.548.726.367', 'D12.776.780.400'], ['D09.400.430', 'D12.776.395'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.465.955.416.812', 'C04.850.... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Golimumab pharmacokinetics after repeated subcutaneous and intravenous administrations in patients with rheumatoid arthritis and the effect of concomitant methotrexate: an open-label, randomized study. | BACKGROUND: The pharmacokinetics of golimumab, a human monoclonal antibody that inhibits the activity of tumor necrosis factor á, after a single subcutaneous (SC) or intravenous (IV) administration have been previously studied.OBJECTIVES: The purpose of this study was to assess the pharmacokinetics of golimumab after m... | ['Adult', 'Aged', 'Antibodies, Monoclonal', 'Antirheumatic Agents', 'Arthritis, Rheumatoid', 'Biomarkers', 'C-Reactive Protein', 'Drug Interactions', 'Drug Therapy, Combination', 'Female', 'Humans', 'Infusions, Intravenous', 'Injections, Subcutaneous', 'Male', 'Methotrexate', 'Middle Aged', 'Models, Biological', 'Treat... | 22,169,051 | [['M01.060.116'], ['M01.060.116.100'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D27.505.954.329'], ['C05.550.114.154', 'C05.799.114', 'C17.300.775.099', 'C20.111.199'], ['D23.101'], ['D12.776.034.145', 'D12.776.124.050.120', 'D12.776.124.486.157'], ['G07.690.773.9... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Efficacy of a commercial glutaraldehyde footbath product for the control of bovine digital dermatitis. | OBJECTIVE: To evaluate the relative efficacy of a novel, commercially available disinfecting agent containing ? 15 to < 20 % glutaraldehyde in a hydro-colloid matrix ("EIM? Klauen Sprint®"; Eimermacher, Nordwalde, Germany, Biozid-Desinfektionsmittel, BAuA Nr. N-57213) as a walkthrough footbath in order to treat digital... | ['Animals', 'Baths', 'Cattle', 'Cattle Diseases', 'Digital Dermatitis', 'Glutaral', 'Hoof and Claw', 'Lameness, Animal', 'Treatment Outcome'] | 30,616,273 | [['B01.050'], ['E02.056.110'], ['B01.050.150.900.649.313.500.380.271'], ['C22.196'], ['C01.150.252.819.180', 'C01.800.720.180', 'C17.800.838.765.180', 'C22.214'], ['D02.047.532'], ['A13.491'], ['C22.510'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Homologous desensitization of ATP-mediated elevations in cytoplasmic calcium and prostacyclin release in human endothelial cells does not involve protein kinase C. | Single human umbilical-vein endothelial cells in culture loaded with the Ca2(+)-sensitive dye fura-2 exhibited characteristic increases in cytosolic Ca2+ concentrations [( Ca2+]i) in response to extracellular ATP. The rapid decline of [Ca2+]i to prestimulated levels in the continued presence of ATP, with in most cells ... | ['Adenosine Triphosphate', 'Alkaloids', 'Calcium', 'Cells, Cultured', 'Cytoplasm', 'Endothelium, Vascular', 'Epoprostenol', 'Histamine', 'Humans', 'Kinetics', 'Staurosporine', 'Tetradecanoylphorbol Acetate', 'Time Factors', 'Umbilical Veins'] | 2,264,825 | [['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['D03.132'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['A11.251'], ['A11.284.430.214'], ['A07.015.700.500', 'A10.272.491.355'], ['D10.251.355.255.550.550.500', 'D23.469.050.175.725.550.500'], ['D02.092.211.215.501', 'D02.092.4... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Has the frequency of bleeding changed over time for patients presenting with an acute coronary syndrome? The global registry of acute coronary events. | AIMS: To determine whether changes in practice, over time, are associated with altered rates of major bleeding in acute coronary syndromes (ACS).METHODS AND RESULTS: Patients from the Global Registry of Acute Coronary Events were enrolled between 2000 and 2007. The main outcome measures were frequency of major bleeding... | ['Acute Coronary Syndrome', 'Aged', 'Aged, 80 and over', 'Angioplasty, Balloon, Coronary', 'Coronary Artery Bypass', 'Female', 'Hematoma, Subdural', 'Hemorrhage', 'Hospitalization', 'Humans', 'Kaplan-Meier Estimate', 'Male', 'Professional Practice', 'Prospective Studies', 'Recurrence', 'Registries', 'Stroke', 'Thrombol... | 20,007,159 | [['C14.280.647.124', 'C14.907.585.124'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E02.148.050.060.100', 'E04.100.376.719.100', 'E04.100.814.529.124.060.100', 'E04.100.814.529.968.050', 'E04.502.382.124.060.100', 'E04.502.382.968.050', 'E04.928.220.520.100', 'E05.157.016.060.100'], ['E04.100.376.719.332', 'E04.10... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Steroid sparing effect of sublingual immunotherapy: real life study in mono/polisensitized children with asthma. | AIM: Steroid-sparing effect of sublingual immunotherapy (SLIT) in mono/polisensitized asthmatic children were evaluated.MATERIALS AND METHODS: Children undergoing allergen-specific SLIT between 2010 and 2014 were included. Asthma control and usage/dose of inhaled corticosteroid (ICS) in the previous year was determined... | ['Administration, Inhalation', 'Adrenal Cortex Hormones', 'Allergens', 'Asthma', 'Child', 'Child, Preschool', 'Female', 'Follow-Up Studies', 'Humans', 'Immunization', 'Male', 'Pollen', 'Sublingual Immunotherapy', 'Treatment Outcome'] | 29,130,803 | [['E02.319.267.050'], ['D06.472.040'], ['D23.050.063'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['M01.060.406'], ['M01.060.406.448'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.095.46... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Ceftaroline Activity Tested Against Bacterial Isolates Causing Community-acquired Respiratory Tract Infections and Skin and Skin Structure Infections in Pediatric Patients From United States Hospitals: 2012-2014. | Ceftaroline fosamil has recently received US Food and Drug Administration approval for treatment of acute bacterial skin/skin structure infections (SSSIs), including those caused by methicillin-resistant Staphylococcus aureus and community-acquired bacterial pneumonia for pediatric patients ?2 months old. We evaluated ... | ['Adolescent', 'Anti-Bacterial Agents', 'Cephalosporins', 'Child', 'Child, Preschool', 'Community-Acquired Infections', 'Enterobacteriaceae', 'Enterobacteriaceae Infections', 'Female', 'Haemophilus influenzae', 'Hospitals', 'Humans', 'Infant', 'Male', 'Methicillin-Resistant Staphylococcus aureus', 'Microbial Sensitivit... | 28,403,050 | [['M01.060.057'], ['D27.505.954.122.085'], ['D02.065.589.099.249', 'D02.886.665.074', 'D03.633.100.300.249'], ['M01.060.406'], ['M01.060.406.448'], ['C01.234'], ['B03.440.450.425', 'B03.660.250.150'], ['C01.150.252.400.310'], ['B03.440.450.600.450.330', 'B03.660.250.550.290.330'], ['N02.278.421'], ['B01.050.150.900.649... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
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