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Antipsychotic use in the elderly: shifting trends and increasing costs. | OBJECTIVE: The purpose of this study was to assess trends in utilization and costs of antipsychotic drugs among a population of older adults over time, with respect to the prevalence of users, shifts in prescribing patterns, and related financial implications.DESIGN: Cross-sectional time series of quarterly and annual ... | ['Aged', 'Antipsychotic Agents', 'Benzodiazepines', 'Cross-Sectional Studies', 'Dibenzothiazepines', 'Drug Costs', 'Humans', 'Mental Disorders', 'Olanzapine', 'Ontario', 'Population Surveillance', 'Quetiapine Fumarate', 'Risperidone'] | 16,035,128 | [['M01.060.116.100'], ['D27.505.696.277.950.040', 'D27.505.954.427.210.950.040', 'D27.505.954.427.700.872.331'], ['D03.633.100.079.080'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['D02.886.680.702.500', 'D03.633.300.276'], ['N03.219.151.400.350', 'N05.300.375.300'], ['B01.050.150.9... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]'] | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
A hospital-based study on ischaemic stroke characteristics, management, and outcomes in Sarawak: Where do we stand? | BACKGROUND: Located on the Borneo Island, Sarawak is the largest state of Malaysia and has a population distinctive from Peninsular Malaysia. The ischaemic stroke data in Sarawak had not been reported despite the growing number of patients annually. We aimed to investigate patient characteristics, management, and outco... | ['Aged', 'Aged, 80 and over', 'Benchmarking', 'Brain Ischemia', 'Female', 'Healthcare Disparities', 'Hospital Mortality', 'Humans', 'Malaysia', 'Male', 'Middle Aged', 'Outcome and Process Assessment, Health Care', 'Patient Discharge', "Practice Patterns, Physicians'", 'Quality Indicators, Health Care', 'Recurrence', 'R... | 32,807,427 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['N04.452.500.150', 'N04.761.685.150', 'N04.761.700.150', 'N05.700.150', 'N05.715.360.650.150'], ['C10.228.140.300.150', 'C14.907.253.092'], ['N04.590.374.380', 'N05.300.493'], ['E05.318.308.985.550.400', 'N01.224.935.698.400', 'N06.850.505.400.975.550.400', 'N06.850.520.3... | ['Named Groups [M]', 'Health Care [N]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
A Quantitative Structure-Property Relationship (QSPR) Study of aliphatic alcohols by the method of dividing the molecular structure into substructure. | A quantitative structure-property relationship (QSPR) analysis of aliphatic alcohols is presented. Four physicochemical properties were studied: boiling point (BP), n-octanol-water partition coefficient (lg P(OW)), water solubility (lg W) and the chromatographic retention indices (RI) on different polar stationary phas... | ['Alcohols', 'Quantitative Structure-Activity Relationship', 'Solubility', 'Transition Temperature', 'Water'] | 21,731,451 | [['D02.033'], ['G02.111.830.500', 'G07.690.773.997.500'], ['G02.805'], ['G01.906.595.850'], ['D01.045.250.875', 'D01.248.497.158.459.650', 'D01.650.550.925']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The effects of ageing and adrenergic challenge on electrocardiographic phenotypes in a murine model of long QT syndrome type 3. | Long QT Syndrome 3 (LQTS3) arises from gain-of-function Nav1.5 mutations, prolonging action potential repolarisation and electrocardiographic (ECG) QT interval, associated with increased age-dependent risk for major arrhythmic events, and paradoxical responses to â-adrenergic agents. We investigated for independent and... | ['Adrenergic Agents', 'Aging', 'Animals', 'Cardiac Conduction System Disease', 'Disease Models, Animal', 'Electrocardiography', 'Fibrosis', 'Heart Function Tests', 'Humans', 'Long QT Syndrome', 'Mice', 'Phenotype'] | 28,894,151 | [['D27.505.519.625.050', 'D27.505.696.577.050'], ['G07.345.124'], ['B01.050'], ['C14.280.123'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['E01.370.370.380.240', 'E01.370.405.240'], ['C23.550.355'], ['E01.370.370.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.280.067.565', 'C14.280.123.625', 'C16.13... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Clinical features of recurrence and osteoporotic changes in benign paroxysmal positional vertigo. | OBJECTIVE: Several previous studies have demonstrated that comorbidities, secondary causes, physical inactivity, and osteoporosis may cause recurrence of benign paroxysmal positional vertigo (BPPV). However, there has also been some controversy over the clinical course(s) and cause(s) of recurrent BPPV (rBPPV). We iden... | ['Absorptiometry, Photon', 'Aged', 'Benign Paroxysmal Positional Vertigo', 'Comorbidity', 'Diabetes Mellitus', 'Female', 'Humans', 'Hypertension', 'Incidence', 'Male', 'Middle Aged', 'Osteoporosis', 'Recurrence', 'Republic of Korea', 'Retrospective Studies', 'Semicircular Canals'] | 27,423,924 | [['E01.370.350.700.024', 'E05.196.712.224.187'], ['M01.060.116.100'], ['C09.218.568.900.883.500', 'C10.597.951.500', 'C23.888.592.958.500'], ['N05.715.350.225', 'N06.850.490.687'], ['C18.452.394.750', 'C19.246'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['E05.318.308.985.525.375', 'N01.224.935.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Are elite cricketers more prone to suicide? A psychological autopsy study of Test cricketer suicides. | OBJECTIVES: It has been hypothesised that the very nature of the game predisposes elite cricketers to higher rates of suicide.AIM: We aim to estimate the suicide rate of male Test cricketers and to determine the reasons for suicide.METHODS: The suicide rate in male Test cricketers was determined. A psychological autops... | ['Adult', 'Aged', 'Australia', 'Biographies as Topic', 'England', 'Humans', 'Male', 'Middle Aged', 'New Zealand', 'Retirement', 'Social Support', 'South Africa', 'Sports', 'Suicide'] | 27,034,441 | [['M01.060.116'], ['M01.060.116.100'], ['Z01.639.100', 'Z01.678.100.373'], ['K01.517.211'], ['Z01.542.363.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['Z01.639.760.747', 'Z01.678.100.747'], ['I03.702'], ['I01.880.853.500.600'], ['Z01.058.290.175.735'], ['I03.450.642.845'], ['F01.145.126... | ['Named Groups [M]', 'Geographicals [Z]', 'Humanities [K]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 |
[Intestinal obstruction caused by non-absorbable tablets and Budd-Chiari syndrome in a patient with Crohn's disease]. | Crohn's disease is a chronic inflammatory granulomatous disorder affecting any part of the gastrointestinal tract, particularly the terminal ileum and the colon. Familiar complications are strictures, fistulae, perforation, haemorrhages and malabsorption due to multiple resections. A patient with two rare complications... | ['Budd-Chiari Syndrome', 'Child', 'Crohn Disease', 'Female', 'Ferrous Compounds', 'Foreign Bodies', 'Humans', 'Intestinal Obstruction', 'Radiography', 'Tablets'] | 2,046,772 | [['C06.552.347', 'C14.907.355.830.925.275'], ['M01.060.406'], ['C06.405.205.731.500', 'C06.405.469.432.500'], ['D01.490.200'], ['C26.392'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C06.405.469.531'], ['E01.370.350.700'], ['D26.255.830']] | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Trends and characteristics of naloxone therapy reported to US poison centers. | BACKGROUND AND AIMS: In the United States, access to naloxone has been expanded as a measure to address growing opioid overdose mortality. The study aimed to describe the national trends in naloxone use as reported to the US poison centers (PCs).METHODS: The National Poison Data System (NPDS) was queried for cases repo... | ['Adolescent', 'Adult', 'Analgesics, Opioid', 'Child', 'Child, Preschool', 'Databases, Factual', 'Drug Overdose', 'Female', 'Humans', 'Male', 'Middle Aged', 'Naloxone', 'Narcotic Antagonists', 'Poison Control Centers', 'Population Growth', 'Retrospective Studies', 'United States', 'Young Adult'] | 29,989,286 | [['M01.060.057'], ['M01.060.116'], ['D27.505.696.277.600.500', 'D27.505.696.663.850.014.760.500', 'D27.505.954.427.040.550.500', 'D27.505.954.427.210.600.500'], ['M01.060.406'], ['M01.060.406.448'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['C25.775.383', 'E02.319.306.500.500'], ['B01.050.150.900.649.313.988... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Information Science [L]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
Effect of immunization with anti-idiotypic antibody to melanoma antigen on lung metastasis in mice. | To determine whether the pulmonary metastases of melanoma cells could be inhibited, C57BL/6 mice were immunized with an anti-idiotypic antibody, 7C4, corresponding to a mouse melanoma antigen. Three groups of mice were compared: 1) 7C4-immunized group which received an injection of 100 micrograms of 7C4 in Freund's com... | ['Animals', 'Antibodies, Anti-Idiotypic', 'Antibodies, Neoplasm', 'Antigens, Neoplasm', 'Female', 'Immunization', 'Lung Neoplasms', 'Melanoma, Experimental', 'Mice', 'Mice, Inbred C57BL'] | 1,306,979 | [['B01.050'], ['D12.776.124.486.485.114.071', 'D12.776.124.790.651.114.071', 'D12.776.377.715.548.114.071'], ['D12.776.124.486.485.114.240', 'D12.776.124.790.651.114.240', 'D12.776.377.715.548.114.240'], ['D23.050.285'], ['E02.095.465.425.400', 'E05.478.550', 'N02.421.726.758.310', 'N06.850.780.200.425', 'N06.850.780.6... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
One-step affinity purification of bacterially produced proteins by means of the "Strep tag" and immobilized recombinant core streptavidin. | The "Strep tag" is a nine amino acid peptide with intrinsic streptavidin-binding activity. If this sequence is genetically fused to the C-terminus of a polypeptide the recombinant protein can be directly purified by affinity chromatography from the host cell extract on immobilized streptavidin. However, variations were... | ['Bacterial Proteins', 'Base Sequence', 'Chromatography, Affinity', 'Electrophoresis, Polyacrylamide Gel', 'Escherichia coli', 'Genetic Vectors', 'Molecular Sequence Data', 'Protein Conformation', 'Recombinant Proteins', 'Streptavidin', 'Streptomyces'] | 7,921,186 | [['D12.776.097'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.196.181.400.170'], ['E05.196.401.402', 'E05.301.300.319'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['G05.360.337'], ['L01.453.245.667'], ['G02.111.570.820.709'], ['D12.776.828'], ['D12.776.097.835'], ['B03.300.390.400.810... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
IMPAD1 and KDELR2 drive invasion and metastasis by enhancing Golgi-mediated secretion. | Non-small cell lung cancer (NSCLC) is the deadliest form of cancer worldwide, due in part to its proclivity to metastasize. Identifying novel drivers of invasion and metastasis holds therapeutic potential for the disease. We conducted a gain-of-function invasion screen, which identified two separate hits, IMPAD1 and KD... | ['Cell Line, Tumor', 'Cell Movement', 'Cell Proliferation', 'Disease Progression', 'Fluorescent Antibody Technique', 'Gene Expression Regulation, Neoplastic', 'Golgi Apparatus', 'Humans', 'Lung Neoplasms', 'Matrix Metalloproteinases', 'Neoplasm Invasiveness', 'Phosphoric Monoester Hydrolases', 'Vesicular Transport Prot... | 32,753,652 | [['A11.251.210.190', 'A11.251.860.180'], ['G04.198', 'G07.568.500.180'], ['G04.161.750', 'G07.345.249.410.750'], ['C23.550.291.656'], ['E01.370.225.500.607.512.240', 'E01.370.225.750.551.512.240', 'E05.200.500.607.512.240', 'E05.200.750.551.512.240', 'E05.478.583.375'], ['G05.308.370'], ['A11.284.430.214.190.875.336'],... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Men's accounts of infertility within their intimate partner relationships: an analysis of online forum discussions. | OBJECTIVE: This article aims to provide insights into men's accounts of infertility in the context of their intimate partnerships.BACKGROUND: Although we are beginning to understand that men experience the emotions of infertility acutely, little is known about how such emotions impact on men's intimate partner relation... | ['Adult', 'Emotions', 'Humans', 'Infertility, Male', 'Internet', 'Interpersonal Relations', 'Male', 'Masculinity', 'Men', 'Self-Help Groups'] | 29,517,356 | [['M01.060.116'], ['F01.470'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.294.365.700'], ['L01.224.230.110.500'], ['F01.829.401'], ['F01.145.813.376', 'F01.393.446.250.750', 'F01.752.747.385.200.750'], ['M01.390'], ['N03.540.782']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Diseases [C]', 'Information Science [L]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Effect of chemotherapy and stem cell transplantation on T lymphocyte clones in familial haemophagocytic lymphohistiocytosis. | Familial haemophagocytic lymphohistiocytosis (FHL) is a rare disorder in infancy, curative only by an allogeneic stem cell transplantation (SCT). We recently confirmed the clonal evidence of T cells in FHL. To confirm the effect of chemotherapy and SCT in FHL, the change of T-cell clones was analysed in two patients us... | ['Clone Cells', 'Female', 'Gene Frequency', 'Genes, T-Cell Receptor', 'Hematopoietic Stem Cell Transplantation', 'Histiocytosis, Non-Langerhans-Cell', 'Humans', 'Immunoglobulin Joining Region', 'Immunoglobulin Variable Region', 'Infant', 'Male', 'Polymorphism, Single-Stranded Conformational', 'Reverse Transcriptase Pol... | 11,380,476 | [['A11.251.353'], ['G05.330'], ['G05.360.340.024.340.475'], ['E02.095.147.500.500.500', 'E04.936.225.687.500'], ['C15.604.250.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.541.500.650.500.590', 'D12.776.124.486.485.680.650.500.590', 'D12.776.124.486.485.797.590', 'D12.776.124.790.651.680.650.500.590... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Named Groups [M]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[The raccoon roundworm (Baylisascaris procyonis)--no zoonotic risk for Brandenburg?]. | The aim of the present study was to investigate the presence of the raccoon roundworm (Baylisascaris [B.] procyonis), a dangerous zoonotic pathogen for humans, in raccoons living in the federal state of Brandenburg, Germany. In the years 2008 to 2013, a total of 762 raccoons, dating from hunting bags, were examined for... | ['Animals', 'Ascaridida Infections', 'Ascaridoidea', 'Germany', 'Raccoons', 'Risk', 'Zoonoses'] | 25,876,283 | [['B01.050'], ['C01.610.335.508.700.100'], ['B01.050.500.500.294.400.500.100'], ['Z01.542.315'], ['B01.050.150.900.649.313.750.250.623.700'], ['E05.318.740.600.800', 'G17.680.750', 'N05.715.360.750.625.700', 'N06.850.520.830.600.800'], ['C01.973', 'C22.969']] | ['Organisms [B]', 'Diseases [C]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Changes in carotid body and nTS neuronal excitability following neonatal sustained and chronic intermittent hypoxia exposure. | We investigated whether pre-treatment with neonatal sustained hypoxia (SH) prior to chronic intermittent hypoxia (SH+CIH) would modify in vitro carotid body (CB) chemoreceptor activity and the excitability of neurons in the caudal nucleus of the solitary tract (nTS). Sustained hypoxia followed by CIH exposure simulates... | ['Animals', 'Animals, Newborn', 'Carotid Body', 'Disease Models, Animal', 'Hypoxia', 'Male', 'Rats', 'Rats, Inbred Lew', 'Solitary Nucleus'] | 25,266,393 | [['B01.050'], ['B01.050.050.282'], ['A08.675.650.915.500.600.150', 'A08.800.950.500.600.150', 'A11.671.650.915.500.600.150'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['C23.888.852.079'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760.280', 'B01.050.150.900.649.313.992.635.505.700.400.280'... | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
CT and MR imaging features of primary central nervous system lymphoma in Norway, 1989-2003. | BACKGROUND AND PURPOSE: Studying imaging findings of non-acquired immunodeficiency syndrome (AIDS) primary central nervous system lymphoma (PCNSL), we hypothesized that the imaging presentation has changed with the increasing incidence of PCNSL and is related to clinical factors (eg, time to diagnosis and the patient's... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Central Nervous System Neoplasms', 'Female', 'Humans', 'Incidence', 'Lymphoma', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Norway', 'Registries', 'Retrospective Studies', 'Risk Factors', 'Tomography, X-Ray Computed', 'Young Adult'] | 19,164,442 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C04.588.614.250', 'C10.551.240'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.985.525.375'], ['C04.557.386', 'C15.604.515.569', 'C20.... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Monoclonal antibodies against the voltage-sensitive Na+ channel from mammalian skeletal muscle. | A panel of 13 monoclonal antibodies against the voltage-sensitive Na+ channel of rat skeletal muscle has been characterized. Each of these antibodies reacted with the purified Na+ channel protein in a solid-phase radioimmunoassay. Nine antibodies specifically immunoprecipitated the Na+ channel in a form that retained i... | ['Animals', 'Antibodies, Monoclonal', 'Antigen-Antibody Complex', 'Epitopes', 'Fluorescent Antibody Technique', 'Ion Channels', 'Mice', 'Mice, Inbred BALB C', 'Muscles', 'Radioimmunoassay', 'Rats', 'Sodium'] | 6,207,539 | [['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D12.776.124.486.485.114.257', 'D12.776.124.790.651.114.257', 'D12.776.377.715.548.114.257', 'D23.050.101'], ['D23.050.550'], ['E01.370.225.500.607.512.240', 'E01.370.225.750.551.512.240', 'E05.200.500.607.512.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Dose-dependent vitamin D3, 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3-induced hypercalcemia and hyperphosphatemia, and the correlative changes in the activity of ultimobranchial and parathyroid glands of the toad, Bufo andersoni Boulenger. | Vitamin D3, 25(OH) vitamin D3 and 1,25 (OH)2D3 were administered daily to unfed male Bufo andersoni for 15 days which resulted in a significant hypercalcemia and hyperphosphatemia in a dose-dependent fashion. 1,25(OH)2D3 is more potent than the other metabolites. The treatment activated ultimobranchial gland but induce... | ['Animals', 'Bufonidae', 'Calcifediol', 'Calcitriol', 'Calcium', 'Cholecalciferol', 'Dose-Response Relationship, Drug', 'Hypercalcemia', 'Male', 'Parathyroid Glands', 'Phosphates', 'Ultimobranchial Body'] | 1,339,166 | [['B01.050'], ['B01.050.150.900.090.180.210'], ['D04.210.500.247.222.159.478.250', 'D04.210.500.247.808.146.478.250', 'D04.210.500.812.768.196.478.250', 'D10.570.938.146.478.250'], ['D04.210.500.247.222.159.478.387.300', 'D04.210.500.247.808.146.478.387.300', 'D04.210.500.812.768.196.478.387.300', 'D10.570.938.146.478.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Biochemical passive reactors for treatment of acid mine drainage: Effect of hydraulic retention time on changes in efficiency, composition of reactive mixture, and microbial activity. | Biochemical passive treatment represents a promising option for the remediation of acid mine drainage. This study determined the effect of three hydraulic retention times (1, 2, and 4 days) on changes in system efficiency, reactive mixture, and microbial activity in bioreactors under upward flow conditions. Bioreactors... | ['Acids', 'Bacteria', 'Biomass', 'Bioreactors', 'Drainage, Sanitary', 'Hydrogen-Ion Concentration', 'Metals', 'Mining', 'Oxidation-Reduction', 'Oxygen', 'Sulfates', 'Sulfides', 'Waste Management'] | 27,016,821 | [['D01.029'], ['B03'], ['G16.500.275.157.100', 'N06.230.124.100'], ['E07.115', 'J01.897.120.115'], ['N06.850.780.200.800.800.350'], ['G02.300'], ['D01.552'], ['J01.576.655.875.500'], ['G02.700', 'G03.295.531'], ['D01.268.185.550', 'D01.362.670'], ['D01.248.497.158.845', 'D01.875.800.800.850'], ['D01.248.497.158.874', '... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Molecular characterisation and inductive expression of a fish protein arginine methyltransferase 1 gene in response to virus infection. | Protein arginine methyltransferase 1 (PRMT1) is currently thought as an effector to regulate interferon (IFN) signalling. Here Paralichthys olivaceus PRMT1 (PoPRMT1) gene was identified as a virally induced gene from UV-inactivated Scophthalmus maximus Rhabdovirus (SMRV)-infected flounder embryonic cells (FEC). PoPMRT1... | ['Amino Acid Sequence', 'Animals', 'Base Sequence', 'Cell Line', 'DNA Primers', 'Embryo, Nonmammalian', 'Fish Diseases', 'Flounder', 'Gene Expression Regulation, Enzymologic', 'Molecular Sequence Data', 'Phylogeny', 'Protein-Arginine N-Methyltransferases', 'RNA, Messenger', 'Reverse Transcriptase Polymerase Chain React... | 17,055,744 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A11.251.210'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['A13.350', 'A16.331'], ['C22.362'], ['B01.050.150.900.493.418.438'], ['G05.308.320'], ['L01.453.245.667'], ['G05.697', 'G16.0... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Proinsulin is refractory to protein fibrillation: topological protection of a precursor protein from cross-beta assembly. | Insulin is susceptible to fibrillation, a misfolding process leading to well ordered cross-beta assembly. Protection from fibrillation in beta cells is provided by sequestration of the susceptible monomer within zinc hexamers. We demonstrate that proinsulin is refractory to fibrillation under conditions that promote th... | ['Kinetics', 'Microscopy, Electron', 'Proinsulin', 'Protein Conformation', 'Protein Folding', 'Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization', 'Thermodynamics'] | 16,239,223 | [['G01.374.661', 'G02.111.490'], ['E01.370.350.515.402', 'E05.595.402'], ['D06.472.699.587.200.500', 'D12.644.548.586.200.500', 'D12.776.811.706'], ['G02.111.570.820.709'], ['G01.154.651', 'G02.111.688'], ['E05.196.566.755'], ['G01.906']] | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Preservation of tissue microstructure and functionality during freezing by modulation of cytoskeletal structure. | Cryopreservation is one of the key enabling technologies for tissue engineering and regenerative medicine, which can provide reliable long-term storage of engineered tissues (ETs) without losing their functionality. However, it is still extremely difficult to design and develop cryopreservation protocols guaranteeing t... | ['Biomechanical Phenomena', 'Cell Survival', 'Collagen Type I', 'Cryopreservation', 'Cytoskeleton', 'Extracellular Matrix', 'Fibroblasts', 'Humans', 'Stress Fibers', 'Tissue Engineering'] | 25,679,482 | [['G01.154.090', 'G01.374.089'], ['G04.346'], ['D05.750.078.280.300.100', 'D12.776.860.300.250.300.100'], ['E01.370.225.500.620.760.160', 'E01.370.225.750.600.760.160', 'E02.792.156', 'E05.200.500.620.760.160', 'E05.200.750.600.760.160', 'E05.760.156'], ['A11.284.430.214.190.750'], ['A11.284.295.310'], ['A11.329.228'],... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Low-grade intravascular coagulation and reticuloendothelial function. | The present study evaluated the influence of experimentally produced intravascular coagulation on reticuloendothelial (RE) stability. Intravascular coagulation was initiated by the intraperitoneal injection of bovine thrombin (500 U/100 g body wt) into male rats. RE function was evaluated by the vascular clearance of a... | ['Animals', 'Disseminated Intravascular Coagulation', 'Fibrin Fibrinogen Degradation Products', 'Injections, Intraperitoneal', 'Kupffer Cells', 'Liver', 'Male', 'Mononuclear Phagocyte System', 'Phagocytosis', 'Rats', 'Regional Blood Flow', 'Thrombin'] | 645,871 | [['B01.050'], ['C15.378.100.220', 'C15.378.463.250', 'C15.378.925.220'], ['D12.776.124.270.300', 'D12.776.811.300.290'], ['E02.319.267.530.490'], ['A11.329.372.588', 'A11.627.482.588', 'A11.733.397.588', 'A15.382.670.522.588', 'A15.382.680.397.588'], ['A03.620'], ['A15.382.670'], ['G04.417.350', 'G09.188.665', 'G12.450... | ['Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Costs and quality of hospitals in different health care systems: a multi-level approach with propensity score matching. | Cross-country comparisons of costs and quality between hospitals are often made at the macro level. The goal of this study was to explore methods to compare micro-level data from hospitals in different health care systems. To do so, we developed a multi-level framework in combination with a propensity score matching te... | ['Aged', 'Delivery of Health Care', 'Germany', 'Hospital Costs', 'Hospital Mortality', 'Hospitals', 'Humans', 'Male', 'Middle Aged', 'Myocardial Infarction', 'Propensity Score', 'Quality of Health Care', 'United States'] | 20,084,662 | [['M01.060.116.100'], ['N04.590.374', 'N05.300'], ['Z01.542.315'], ['N03.219.151.400.687', 'N03.219.262.500', 'N05.300.375.500'], ['E05.318.308.985.550.400', 'N01.224.935.698.400', 'N06.850.505.400.975.550.400', 'N06.850.520.308.985.550.400'], ['N02.278.421'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.... | ['Named Groups [M]', 'Health Care [N]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Characterization of the aldose reductase-encoding gene family in rat. | Although the enzyme aldose reductase (AR) is implicated in the development of tissue pathology in diabetes, the exact mechanism of this involvement remains unclear. To better understand the role that expression of the aldose reductase-encoding gene (ALR) may play in diabetic complications, we have begun to analyze the ... | ['Aldehyde Reductase', 'Animals', 'Base Sequence', 'Blotting, Southern', 'Chromosome Mapping', 'Consensus Sequence', 'Diabetes Mellitus, Experimental', 'Exons', 'Gene Expression', 'Hybrid Cells', 'Introns', 'Mice', 'Molecular Sequence Data', 'Multigene Family', 'Pseudogenes', 'Rats', 'Sequence Homology, Nucleic Acid'] | 1,748,296 | [['D08.811.682.047.150.700.156.500', 'D08.811.682.047.820.284.500'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.196.401.114', 'E05.301.300.087', 'E05.601.150'], ['E05.393.183'], ['G02.111.570.580.175'], ['C18.452.394.750.074', 'C19.246.240', 'E05.598.500.374'], ['G05.360.340.024.340.1... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
A Practical Study of Diagnostic Accuracy: Scoliosis Screenings of Middle School Students by a Trained Nurse With a Smartphone Versus a Spine Surgeon With a Scoliometer. | STUDY DESIGN: Cross-sectional.OBJECTIVE: This study aimed to assess the accuracy of smartphone-aided diagnosis of scoliosis by a trained nurse compared with scoliometer-based diagnosis by a spine surgeon.SUMMARY OF BACKGROUND DATA: Many assessments have been developed to estimate the reliability of smartphone-aided mea... | ['Adolescent', 'Cross-Sectional Studies', 'Female', 'Humans', 'Male', 'Mass Screening', 'ROC Curve', 'Radiography', 'Reproducibility of Results', 'Research Design', 'Rotation', 'Scoliosis', 'Single-Blind Method', 'Smartphone', 'Spine', 'Surgeons', 'Torso'] | 31,568,349 | [['M01.060.057'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.500', 'E05.318.308.980.438.580', 'N02.421.726.233.443', 'N05.715.360.300.800.438.500', 'N06.850.520.308.980.438.580', 'N06.850.780.500'], ['E05.318.370.800.750', 'E... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Information Science [L]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 |
Humor in the eye tracker: attention capture and distraction from context cues. | The humor effect refers to a robust finding in memory research that humorous information is easily recalled, at the expense of recall of nonhumorous information that was encoded in close temporal proximity. Previous research suggests that memory retrieval processes underlie this effect. That is, free recall is biased t... | ['Analysis of Variance', 'Association Learning', 'Attention', 'Cues', 'Eye Movement Measurements', 'Eye Movements', 'Female', 'Humans', 'Male', 'Mental Recall', 'Photic Stimulation', 'Recognition, Psychology', 'Wit and Humor as Topic'] | 20,198,815 | [['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['F02.463.425.069.296'], ['F02.830.104.214'], ['F02.463.425.234'], ['E01.370.380.230', 'E01.370.405.245.787'], ['G11.427.410.140', 'G14.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.425.540.641'], ['E05.723.729'], ['F02.463.425.540.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Humanities [K]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Dialysability of gadoteric acid in patients with end-stage renal disease undergoing hemodialysis. | OBJECTIVE: This study was designed to evaluate the dialysability of gadoteric acid in patients with end-stage renal disease (ESRD) requiring hemodialysis. Gadoteric acid is used for magnetic resonance imaging. It is cleared from the blood exclusively by glomerular filtration. In an attempt to decrease the occurrence of... | ['Adult', 'Aged', 'Biological Availability', 'Contrast Media', 'Extravasation of Diagnostic and Therapeutic Materials', 'Female', 'Heterocyclic Compounds', 'Humans', 'Kidney', 'Kidney Failure, Chronic', 'Male', 'Metabolic Clearance Rate', 'Middle Aged', 'Organometallic Compounds', 'Patient Safety', 'Renal Dialysis', 'R... | 24,619,209 | [['M01.060.116'], ['M01.060.116.100'], ['G03.787.151', 'G07.690.725.129'], ['D27.505.259.500', 'D27.720.259'], ['C23.550.340', 'C26.371'], ['D03'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A05.810.453'], ['C12.777.419.780.750.500', 'C13.351.968.419.780.750.500'], ['E01.370.225.843', 'E05.200.843', 'G03.490', ... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Establishment of a Reliable Horizontal Reference Plane for 3-Dimensional Facial Soft Tissue Evaluation Before and After Orthognathic Surgery. | BACKGROUND: This study aims to demonstrate the reliability of our proposed facial reference system in the horizontal axis using 3-dimensional photogrammetry and to find a correlation between this plane and the Frankfurt horizontal (FH) plane.METHODS: Forty-one patients were enrolled. Three-dimensional facial images wer... | ['Adolescent', 'Adult', 'Anatomic Landmarks', 'Cone-Beam Computed Tomography', 'Face', 'Female', 'Humans', 'Imaging, Three-Dimensional', 'Male', 'Orthognathic Surgical Procedures', 'Photogrammetry', 'Reference Values', 'Reproducibility of Results'] | 28,195,892 | [['M01.060.057'], ['M01.060.116'], ['A01.111'], ['E01.370.350.700.810.810.490', 'E01.370.350.825.810.810.399'], ['A01.456.505'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.400', 'L01.224.308.410'], ['E04.545.562', 'E04.555.580.289', 'E06.645.562'], ['E01.370.350.600.630'], ['E05.978.810'], ['E05.318... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Information Science [L]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Characterization of interleukin-1 receptor-associated kinase 1 binding protein 1 gene in small abalone Haliotis diversicolor. | Interleukin receptor-associated kinase (IRAK)-1 binding protein 1 (IRAK1BP1) is a critical factor in preventing dangerous overproduction of proinflammatory cytokines by the innate immune system and in influencing the specificity of TLR responses. In this study, a first molluscan IRAK1BP1 gene, saIRAK1BP1, was cloned fr... | ['Amino Acid Sequence', 'Animals', 'Base Sequence', 'Cloning, Molecular', 'DNA, Complementary', 'Gastropoda', 'Gene Expression Profiling', 'Gene Expression Regulation, Developmental', 'Immunity, Innate', 'Interleukin-1 Receptor-Associated Kinases', 'Models, Genetic', 'Molecular Sequence Data', 'Mollusca', 'Phylogeny', ... | 22,781,544 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.393.220'], ['D13.444.308.497.220', 'D13.444.600.223.500', 'D27.720.470.530.600.223.260'], ['B01.050.500.644.400'], ['E05.393.332'], ['G05.308.310'], ['G12.450.564'], ['D08.811.913.696.620.682.700.5... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
The management of open fractures associated with arterial injury requiring vascular repair. | Seventy-two open fractures associated with arterial injury requiring vascular repair (Gustilo type IIIC injuries) were treated at the University of Louisville from May 1983 and through 1992. The involved anatomic areas were the humerus (four), forearm (ten), femur (eight), tibia (31), ankle (ten), and foot (nine). Frac... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Amputation', 'Arteries', 'Drug Implants', 'Female', 'Fracture Fixation', 'Fractures, Open', 'Humans', 'Male', 'Methylmethacrylates', 'Middle Aged', 'Tobramycin', 'Wound Infection'] | 7,996,607 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E04.555.080'], ['A07.015.114'], ['D26.255.210.315'], ['E04.555.300'], ['C26.404.311'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.241.081.069.800.550', 'D05.750.716.822.111.650.605', 'D25.720.716.822.111.650.605', 'J01.637.05... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 |
Role of rodent secondary motor cortex in value-based action selection. | Despite widespread neural activity related to reward values, signals related to upcoming choice have not been clearly identified in the rodent brain. Here we examined neuronal activity in the lateral (AGl) and medial (AGm) agranular cortex, corresponding to the primary and secondary motor cortex, respectively, in rats ... | ['Action Potentials', 'Animals', 'Brain Mapping', 'Choice Behavior', 'Decision Making', 'Logistic Models', 'Male', 'Maze Learning', 'Motor Cortex', 'Movement', 'Neurons', 'Rats', 'Reaction Time', 'Reinforcement, Psychology', 'Time Factors'] | 21,841,777 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['B01.050'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['F02.463.785.373.346'], ['F02.463.785.373'], ['E05.318.740.500.525', 'E05.318.740.600.800.450', 'E05.318.740.750.450', 'E05.599.835.875', 'N05.715.360.750.530.480', 'N05.715.3... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Kinetics versus Thermodynamics in Virus Capsid Polymorphism. | Virus coat proteins spontaneously self-assemble into empty shells in aqueous solution under the appropriate physicochemical conditions, driven by an interaction free energy per bond on the order of 2-5 times the thermal energy kBT. For this seemingly modest interaction strength, each protein building block nonetheless ... | ['Capsid', 'Capsid Proteins', 'Hepatitis B virus', 'Kinetics', 'Thermodynamics', 'Virion', 'Virus Assembly'] | 27,027,925 | [['A21.249.500.250'], ['D12.776.964.970.600.550'], ['B04.280.375.650.425', 'B04.450.390.650.425'], ['G01.374.661', 'G02.111.490'], ['G01.906'], ['A21.249'], ['G06.920.925.950']] | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cerebral Critical Closing Pressure During Infusion Tests. | We studied possible correlations between cerebral hemodynamic indices based on critical closing pressure (CrCP) and cerebrospinal fluid (CSF) compensatory dynamics, as assessed during lumbar infusion tests. Our data consisted of 34 patients with normal-pressure hydrocephalus who undertook an infusion test, in conjuncti... | ['Adult', 'Aged', 'Arterial Pressure', 'Blood Flow Velocity', 'Cerebrospinal Fluid', 'Cerebrovascular Circulation', 'Female', 'Hemodynamics', 'Humans', 'Hydrocephalus, Normal Pressure', 'Hydrodynamics', 'Infusions, Parenteral', 'Intracranial Pressure', 'Male', 'Middle Aged', 'Retrospective Studies', 'Ultrasonography, D... | 27,165,909 | [['M01.060.116'], ['M01.060.116.100'], ['G09.330.380.076.347'], ['E01.370.370.130', 'G09.330.380.630.080'], ['A12.207.270.210'], ['G09.330.100.159'], ['G09.330.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.228.140.602.750'], ['G01.342'], ['E02.319.267.510'], ['G11.561.170.505'], ['M01.060.116.630'], ['E... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Syphilitic outer retinopathy. | PURPOSE: To present ocular syphilis masquerading as an outer retinopathy.METHODS: Retrospective case series, including 2 patients with features of acute zonal occult outer retinopathy (AZOOR) complex diseases.RESULTS: Laboratory results confirmed the diagnosis of syphilis in the 2 cases. Therapy with intravenous penici... | ['Adult', 'Anti-Bacterial Agents', 'Diagnosis, Differential', 'Drug Therapy, Combination', 'Electroretinography', 'Eye Infections, Bacterial', 'Glucocorticoids', 'Humans', 'Male', 'Middle Aged', 'Penicillin G', 'Prednisone', 'Retrospective Studies', 'Scotoma', 'Syphilis', 'Tomography, Optical Coherence', 'Visual Acuity... | 24,171,649 | [['M01.060.116'], ['D27.505.954.122.085'], ['E01.171'], ['E02.319.310'], ['E01.370.380.225', 'E01.370.405.270'], ['C01.150.252.289', 'C01.375.354', 'C11.294.354'], ['D06.472.040.543', 'D27.505.696.399.472.488'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['D02.065.589.099.750.750', 'D02.886.1... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[The changes of esophageal epithelial intercellular spaces before and after omeprazole treatment in erosive esophagitis]. | OBJECTIVE: To observe the changes of ultra-micro structure of esophageal epithelium in patients with erosive esophagitis before and after omeprazole treatment.METHODS: 20 patients with erosive esophagitis diagnosed with gastroscopy were enrolled. All of them were treated with omeprazole (20 mg, 2/d) for 4 weeks, then u... | ['Adolescent', 'Adult', 'Aged', 'Anti-Ulcer Agents', 'Epithelial Cells', 'Esophagitis, Peptic', 'Extracellular Space', 'Female', 'Gastroscopy', 'Humans', 'Male', 'Middle Aged', 'Omeprazole', 'Treatment Outcome'] | 17,445,428 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.483.203'], ['A11.436'], ['C06.405.117.620.420', 'C06.405.205.663.420', 'C06.405.469.275.800.523', 'C06.405.748.586.524'], ['A10.082.500', 'A11.284.295'], ['E01.370.372.250.250.325', 'E01.370.388.250.250.250.320', 'E04.210.240.250.320', 'E04.502.250.2... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Experimental model for systematic study of impaired microvascular reperfusion. | A technique is described for reliably producing quantifiable impairment of microvascular reperfusion of the brain after ischemia in dogs. The technique is derived from an analysis of the cerebrospinal fluid compression ischemia model as a Starling resistor. It is proposed that this model would be useful in systematic s... | ['Animals', 'Blood Pressure', 'Cerebrospinal Fluid', 'Cerebrovascular Circulation', 'Disease Models, Animal', 'Dogs', 'Ischemic Attack, Transient', 'Male', 'Microcirculation', 'Pressure'] | 847,789 | [['B01.050'], ['E01.370.600.875.249', 'G09.330.380.076'], ['A12.207.270.210'], ['G09.330.100.159'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['B01.050.150.900.649.313.750.250.216.200'], ['C10.228.140.300.150.836', 'C14.907.253.092.836'], ['G09.330.100.645'], ['G01.374.715']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
An additional fluorenylmethoxycarbonyl (Fmoc) moiety in di-Fmoc-functionalized L-lysine induces pH-controlled ambidextrous gelation with significant advantages. | In recent years, several fluorenylmethoxycarbonyl (Fmoc)-functionalized amino acids and peptides have been used to construct hydrogels, which find a wide range of applications. Although several hydrogels have been prepared from mono Fmoc-functionalized amino acids, herein, we demonstrate the importance of an additional... | ['Amino Acids', 'Azo Compounds', 'Bacillus subtilis', 'Circular Dichroism', 'Elasticity', 'Escherichia coli', 'Fluorenes', 'Hydrogels', 'Hydrogen-Ion Concentration', 'Kinetics', 'Lysine', 'Microscopy, Atomic Force', 'Molecular Weight', 'Spectroscopy, Fourier Transform Infrared', 'Temperature', 'Viscosity'] | 26,338,226 | [['D12.125'], ['D02.172'], ['B03.300.390.400.158.218.725', 'B03.353.500.100.218.725', 'B03.510.100.100.218.725', 'B03.510.415.400.158.218.725', 'B03.510.460.410.158.218.725'], ['E05.196.867.151'], ['G01.374.590'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D02.455.426.559.847.389', 'D04.615.389'], ['D20.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Moral identity as moral ideal self: links to adolescent outcomes. | The purposes of this study were to conceptualize moral identity as moral ideal self, to develop a measure of this construct, to test for age and gender differences, to examine links between moral ideal self and adolescent outcomes, and to assess purpose and social responsibility as mediators of the relations between mo... | ['Adolescent', 'Child', 'Concept Formation', 'Defense Mechanisms', 'Environment', 'Factor Analysis, Statistical', 'Female', 'Humans', 'Internal-External Control', 'Male', 'Models, Psychological', 'Morals', 'Motivation', 'Personality', 'Psychology, Adolescent', 'Self Concept', 'Social Behavior', 'Surveys and Questionnai... | 23,895,167 | [['M01.060.057'], ['M01.060.406'], ['F02.463.785.233'], ['F01.393'], ['G16.500.275', 'N06.230'], ['E05.318.740.400', 'N05.715.360.750.350', 'N06.850.520.830.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.379'], ['E05.599.695'], ['F01.829.500', 'K01.752.566'], ['F01.658', 'F01.752.543.500.750'], ['F01... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Humanities [K]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
NADPH-diaphorase-positive cell populations in the human amygdala and temporal cortex: neuroanatomy, peptidergic characteristics and aspects of aging and Alzheimer's disease. | Previous studies have shown that nerve cells containing NADPH-diaphorase (NADPH-d) are relatively resistant to various damaging processes. NADPH-d has been found to be colocalized with somatostatin (SOM) and neuropeptide Y (NPY) in neuronal populations of several forebrain regions. We have investigated the anatomical d... | ['Adult', 'Aged', 'Aged, 80 and over', 'Aging', 'Alzheimer Disease', 'Amygdala', 'Female', 'Humans', 'Immunohistochemistry', 'Male', 'Middle Aged', 'NADPH Dehydrogenase', 'Neurites', 'Neurofibrillary Tangles', 'Neuropeptides', 'Staining and Labeling', 'Temporal Lobe'] | 1,378,987 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['G07.345.124'], ['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['A08.186.211.180.090', 'A08.186.211.200.885.287.249.152'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Dimerization in tailoring uptake efficacy of the HSV-1 derived membranotropic peptide gH625. | gH625 constitutes a promising delivery vehicle for the transport of therapeutic biomacromolecules across membrane barriers. We report an application of multivalency to create a complex nanosystem for delivery and to elucidate the mechanism of peptide-lipid bilayer interactions. Multivalency may offer a route to enhance... | ['Amino Acid Sequence', 'Biological Transport', 'Cell Membrane', 'Lipid Bilayers', 'Lipids', 'Membrane Fluidity', 'Peptides', 'Protein Aggregates', 'Protein Binding', 'Protein Multimerization', 'Surface Plasmon Resonance', 'Viral Envelope Proteins'] | 28,842,580 | [['G02.111.570.060', 'L01.453.245.667.060'], ['G03.143'], ['A11.284.149'], ['D10.570.510', 'J01.637.087.500.510'], ['D10'], ['G01.154.500', 'G02.111.550', 'G04.570'], ['D12.644'], ['D05.875'], ['G02.111.679', 'G03.808'], ['G02.111.694'], ['E05.196.890', 'E05.601.043.700'], ['D09.400.430.968', 'D12.776.395.550.993', 'D1... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Current and future perspectives regarding the framework for nurse anesthesia education: nurse anesthesia education within the framework of nursing education. | The experience of a hospital-based certificate program when it transfers ownership to a university and becomes a program in the School of Nursing is related. Earlier attempts to make such a move, steps in the planning process and the changing attitudes of university administrators are all explored. The advantages and d... | ['Curriculum', 'Education, Nursing, Graduate', 'Nurse Anesthetists', 'Pennsylvania', 'Universities'] | 1,957,577 | [['I02.158'], ['I02.358.337.450', 'I02.358.462.565'], ['M01.526.485.140.650', 'M01.526.485.650.648.500', 'N02.360.140.650', 'N02.360.650.648.500'], ['Z01.107.567.875.075.550', 'Z01.107.567.875.350.550', 'Z01.107.567.875.500.550'], ['I02.783.830', 'J03.832.830']] | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Named Groups [M]', 'Health Care [N]', 'Geographicals [Z]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
Internalization of flax rust avirulence proteins into flax and tobacco cells can occur in the absence of the pathogen. | Translocation of pathogen effector proteins into the host cell cytoplasm is a key determinant for the pathogenicity of many bacterial and oomycete plant pathogens. A number of secreted fungal avirulence (Avr) proteins are also inferred to be delivered into host cells, based on their intracellular recognition by host re... | ['Amino Acid Sequence', 'Basidiomycota', 'Cytoplasm', 'Flax', 'Fungal Proteins', 'Molecular Sequence Data', 'Plant Diseases', 'Protein Sorting Signals', 'Protein Transport', 'Tobacco'] | 20,525,849 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.300.179'], ['A11.284.430.214'], ['B01.650.940.800.575.912.250.859.797.620.500'], ['D12.776.354'], ['L01.453.245.667'], ['G15.610'], ['D12.644.770', 'G02.111.570.060.670'], ['G03.143.700'], ['B01.650.940.800.575.912.250.908.500.900']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Effects of central and peripheral pretreatment with fluoxetine in gustatory conditioning. | The administration of fluoxetine, a relatively specific serotonin uptake inhibitor, an hour prior to a taste-drug pairing was shown to attenuate the acquisition of taste aversions in a dose-dependent manner. Desipramine which is less effective than fluoxetine in blocking the reuptake of serotonin was also less potent i... | ['5-Hydroxytryptophan', 'Animals', 'Chlorides', 'Conditioning, Classical', 'Dopamine', 'Fluoxetine', 'Lithium', 'Lithium Chloride', 'Male', 'Norepinephrine', 'Propylamines', 'Raphe Nuclei', 'Rats', 'Serotonin', 'Sucrose', 'Taste'] | 6,292,958 | [['D12.125.072.050.850.479'], ['B01.050'], ['D01.210.450.150', 'D01.248.497.158.215'], ['F02.463.425.179.308'], ['D02.092.211.215.406', 'D02.092.311.342', 'D02.455.426.559.389.657.166.175.342'], ['D02.092.831.280'], ['D01.268.549.450', 'D01.268.557.290', 'D01.552.528.480', 'D01.552.547.290'], ['D01.210.450.150.450', 'D... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Biotransformation of the mycotoxin, zearalenone, to a non-estrogenic compound by a fungal strain of Clonostachys sp. | Zearalenones are mycotoxins with estrogenic activity consisting of a resorcinol moiety fused to a 14-membered macrocyclic lactone and are produced by various Fusarium species. We found that Clonostachys rosea IFO 7063 was effectively capable of converting zearalenone (1) to cleavage product (2), 1-(3,5-dihydroxyphenyl)... | ['Ascomycota', 'Biotransformation', 'Breast Neoplasms', 'Cell Division', 'Estrogens', 'Humans', 'Ketones', 'Magnetic Resonance Spectroscopy', 'Molecular Structure', 'Resorcinols', 'Tumor Cells, Cultured', 'Zearalenone'] | 12,596,876 | [['B01.300.107'], ['G03.171', 'G03.787.225', 'G07.690.725.225'], ['C04.588.180', 'C17.800.090.500'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['D27.505.696.399.472.277'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.522'], ['E05.196.867.519'], ['G02.111.570', 'G02.466'], ['D02... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Quantitative morphological analysis reveals ultrastructural diversity of amyloid fibrils from alpha-synuclein mutants. | High resolution atomic force microscopy is a powerful tool to characterize nanoscale morphological features of protein amyloid fibrils. Comparison of fibril morphological properties between studies has been hampered by differences in analysis procedures and measurement error determination used by various authors. We de... | ['Amyloid', 'Biophysics', 'Humans', 'Microscopy, Atomic Force', 'Models, Biological', 'Mutation', 'Nanoparticles', 'Nanotechnology', 'Temperature', 'Time Factors', 'alpha-Synuclein'] | 16,997,873 | [['D05.500.049', 'D12.776.049'], ['H01.158.344', 'H01.671.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.515.666.400', 'E05.595.666.400'], ['E05.599.395'], ['G05.365.590'], ['J01.637.512.600'], ['H01.603', 'J01.897.520.600'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.... | ['Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 |
Angiotensin I converting enzyme activity in uranyl nitrate induced acute renal failure in rats. | Angiotensin I converting enzyme (ACE) was measured in urine, serum, and tissues from rats with acute renal failure (ARF) induced by a single subcutaneous injection (15 mg/kg BW) of uranyl nitrate (UN). Urine was collected daily until day 5, when rats were sacrificed by decapitation for the obtention of blood serum and ... | ['Acetylglucosaminidase', 'Acute Kidney Injury', 'Animals', 'Dipeptidyl Peptidase 4', 'Kidney Cortex', 'Kidney Glomerulus', 'Kidney Tubules, Proximal', 'Male', 'Microscopy, Electron', 'Peptidyl-Dipeptidase A', 'Rats', 'Rats, Wistar', 'Time Factors', 'Uranyl Nitrate'] | 7,569,110 | [['D08.811.277.450.483.180.500'], ['C12.777.419.780.050', 'C13.351.968.419.780.050'], ['B01.050'], ['D08.811.277.656.350.350.126', 'D08.811.277.656.959.250', 'D23.050.301.264.894.160', 'D23.101.100.894.160'], ['A05.810.453.324'], ['A05.810.453.324.359', 'A05.810.453.736.520'], ['A05.810.453.736.560.570'], ['E01.370.350... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Targeted inactivation of Hoxb8 affects survival of a spinal ganglion and causes aberrant limb reflexes. | Hoxb8 mutant mice were generated by inserting the lacZ coding sequence in frame with the first exon of Hoxb8. These mice express a fusion protein with a functional beta-galactosidase activity instead of Hoxb8. Mutant embryos were analyzed for anatomical changes. The results indicate that Hoxb8 is not an indispensable r... | ['Animals', 'Body Patterning', 'Exons', 'Extremities', 'Female', 'Ganglia, Spinal', 'Gene Expression Regulation, Developmental', 'Gene Silencing', 'Homeodomain Proteins', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Mice, Inbred Strains', 'Mice, Mutant Strains', 'Movement Disorders', 'Recombinant Fusion Proteins', 'Reflex, A... | 10,559,485 | [['B01.050'], ['G07.345.500.100'], ['G05.360.340.024.340.137.232'], ['A01.378'], ['A08.340.390.340', 'A08.800.350.340', 'A08.800.800.720.725.350'], ['G05.308.310'], ['G05.308.203.374'], ['D12.776.260.400'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Imaging diagnosis--spinal cord histiocytic sarcoma in a dog. | A 12-year-old mixed breed dog was presented for evaluation of progressive paraparesis and ataxia. Magnetic resonance (MR) imaging was performed and identified multifocal intradural spinal cord mass lesions. The lesions were hyperintense in T2-weighted sequences, isointense to mildly hyperintense in T1-weighted sequence... | ['Animals', 'Ataxia', 'Contrast Media', 'Diagnosis, Differential', 'Dog Diseases', 'Dogs', 'Histiocytic Sarcoma', 'Image Enhancement', 'Magnetic Resonance Imaging', 'Male', 'Paraparesis', 'Spinal Cord Diseases', 'Spinal Cord Neoplasms'] | 24,382,300 | [['B01.050'], ['C10.597.350.090', 'C23.888.592.350.090'], ['D27.505.259.500', 'D27.720.259'], ['E01.171'], ['C22.268'], ['B01.050.150.900.649.313.750.250.216.200'], ['C04.557.227.380', 'C15.604.250.390.380'], ['E01.370.350.600.350', 'L01.224.308.380'], ['E01.370.350.825.500'], ['C10.597.636.500', 'C23.888.592.643.500']... | ['Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Measuring Exposure to Incarceration Using the Electronic Health Record. | BACKGROUND: Electronic health records (EHRs) are a rich source of health information; however social determinants of health, including incarceration, and how they impact health and health care disparities can be hard to extract.OBJECTIVE: The main objective of this study was to compare sensitivity and specificity of pa... | ['Administrative Claims, Healthcare', 'Adult', 'Cohort Studies', 'Electronic Health Records', 'Ethnic Groups', 'Female', 'Humans', 'Information Storage and Retrieval', 'Male', 'Medicare', 'Middle Aged', 'Natural Language Processing', 'Prisoners', 'Self Report', 'Sensitivity and Specificity', 'United States', 'United St... | 31,095,055 | [['N04.452.859.564.137'], ['M01.060.116'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E05.318.308.940.968.625.500', 'N04.452.859.564.650.125', 'N05.715.360.300.715.500.530.250', 'N06.850.520.308.940.968.625.250'], ['M01.686.754', 'N01.224.317'], ['B01.050.150.900.649.313.988.400.11... | ['Health Care [N]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Information Science [L]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
Avian malaria on Madagascar: bird hosts and putative vector mosquitoes of different Plasmodium lineages. | BACKGROUND: Avian malaria occurs almost worldwide and is caused by Haemosporida parasites (Plasmodium, Haemoproteus and Leucocytozoon). Vectors such as mosquitoes, hippoboscid flies or biting midges are required for the transmission of these parasites. There are few studies about avian malaria parasites on Madagascar b... | ['Animals', 'Birds', 'Cytochromes b', 'DNA, Mitochondrial', 'DNA, Protozoan', 'Madagascar', 'Malaria, Avian', 'Mosquito Vectors', 'Polymerase Chain Reaction'] | 28,057,063 | [['B01.050'], ['B01.050.150.900.248'], ['D08.244.187.249', 'D12.776.422.220.187.249'], ['D13.444.308.283.225'], ['D13.444.308.442'], ['Z01.639.520.500'], ['C01.610.752.530.606', 'C01.920.875.606', 'C22.131.498'], ['N06.850.335.188.100.500.500', 'N06.850.520.203.375.100.500.500'], ['E05.393.620.500']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Diseases [C]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
The importance of science communication in cancer research: an interview with Martin Christlieb. | I trained as a chemist, studying for a PhD at the University of Cambridge. After I left Cambridge, I undertook postdoctoral appointments at Stanford and Oxford. These appointments led me into metal chemistry, initially using the metals as reagents, and finally using metal atoms as the key atom in a series of compounds ... | ['Biomedical Research', 'Biomedical Technology', 'Humans', 'Interdisciplinary Communication', 'Medical Oncology', 'Neoplasms', 'Positron-Emission Tomography', 'Radioactive Tracers', 'Research Personnel', 'United Kingdom', 'Universities'] | 29,957,072 | [['H01.770.644.145'], ['J01.897.120.050'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.401.205.249', 'L01.143.865.500'], ['H02.403.429.515'], ['C04'], ['E01.370.350.350.800.700', 'E01.370.350.600.350.800.399', 'E01.370.350.710.800.399', 'E01.370.350.825.800.399', 'E01.370.384.730.800.399'], ['D01.496.749... | ['Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Information Science [L]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Named Groups [M]', 'Geographicals [Z]', 'Anthr... | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 |
The influence of intestinal (ceca) flora on serum and egg yolk cholesterol levels in laying hens. | Normal and cecectomized laying hens were used to study the influence of intestinal (ceca) flora and the implantation of Lactobacillus acidophylus on the levels of serum and egg yolk cholesterol. The ceca had been surgically removed when the experimental birds were 16 months of age. Serum cholesterol levels of cecectomi... | ['Animals', 'Cecum', 'Chickens', 'Cholesterol', 'Egg Yolk', 'Female', 'Lactobacillus acidophilus', 'Oviposition'] | 819,912 | [['B01.050'], ['A03.556.124.526.209', 'A03.556.249.249.209'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['A16.690.325', 'G07.203.300.470.800', 'J02.500.470.800'], ['B03.353.750.450.475.100', 'B03.510.460.400.410.475.475.100... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Compound screening platform using human induced pluripotent stem cells to identify small molecules that promote chondrogenesis. | Articular cartilage, which is mainly composed of collagen II, enables smooth skeletal movement. Degeneration of collagen II can be caused by various events, such as injury, but degeneration especially increases over the course of normal aging. Unfortunately, the body does not fully repair itself from this type of degen... | ['Cell Differentiation', 'Chondrocytes', 'Chondrogenesis', 'Drug Evaluation, Preclinical', 'Genes, Reporter', 'Humans', 'Induced Pluripotent Stem Cells', 'Keratinocytes', 'Luciferases', 'Peptides', 'Reproducibility of Results', 'Small Molecule Libraries'] | 23,161,332 | [['G04.152'], ['A11.329.171'], ['G07.345.500.325.377.625.180', 'G11.427.578.180'], ['E05.290.750', 'E05.337.550'], ['G05.360.340.024.340.435'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.872.040.500', 'A11.872.700.500'], ['A11.409.500', 'A11.436.397'], ['D08.811.682.517', 'D12.776.532.510'], ['D12.644'], ['... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Toxoplasma retinitis following intravitreal injection of triamcinolone acetonide: A case report and review of literature. | The aim of this study was to report a case of atypical toxoplasma retinochoroiditis following intravitreal triamcinolone acetonide (IVTA) injection and to review the literature pertaining to toxoplasma retinochoroiditis following intravitreal injection of corticosteroid. Clinical data were collected from a 64-year-old ... | ['Eye Infections, Parasitic', 'Glucocorticoids', 'Humans', 'Intravitreal Injections', 'Male', 'Middle Aged', 'Retina', 'Retinitis', 'Tomography, Optical Coherence', 'Toxoplasma', 'Toxoplasmosis, Ocular', 'Triamcinolone Acetonide'] | 30,038,184 | [['C01.610.300', 'C11.294.725'], ['D06.472.040.543', 'D27.505.696.399.472.488'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.267.530.475.500'], ['M01.060.116.630'], ['A09.371.729'], ['C11.768.773'], ['E01.370.350.589.249.500', 'E01.370.350.825.805.500', 'E05.642.249.500'], ['B01.043.075.189.250.750.800']... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Opinion of the Scientific Committee on Consumer safety (SCCS) - Opinion on the safety of the use of Methylisothiazolinone (MI) (P94), in cosmetic products (sensitisation only). | CONCLUSION OF THE OPINION: The information provided does not support the safe use of MI as a preservative in rinse-off cosmetic products up to a concentration limit of 100 ppm from the view of induction of contact allergy. For rinse-off cosmetic products, a concentration of 15 ppm (0.0015%) MI is considered safe for th... | ['Animals', 'Consumer Product Safety', 'Cosmetics', 'Dermatitis, Allergic Contact', 'Dose-Response Relationship, Drug', 'Humans', 'Preservatives, Pharmaceutical', 'Risk Assessment', 'Risk Factors', 'Thiazoles', 'Toxicity Tests'] | 26,790,577 | [['B01.050'], ['N06.850.210'], ['D27.720.269', 'J01.516.213'], ['C17.800.174.255.100', 'C17.800.815.255.100', 'C20.543.418.150'], ['G07.690.773.875', 'G07.690.936.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D26.650.702', 'D27.720.744.771'], ['E05.318.740.600.800.715', 'N04.452.871.715', 'N05.715.360.750.6... | ['Organisms [B]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Radiotherapy in the management of cutaneous B-cell lymphoma. Our experience in 25 cases. | PURPOSE: To report our results in the treatment with radiation therapy of 25 patients affected by B-cell lymphoma with initial cutaneous presentation.MATERIALS AND METHODS: From October 1978 to June 1997, we have treated 25 patients with cutaneous B-cell lymphoma (CBCL) by cutaneous irradiation. There were 17 males and... | ['Adult', 'Aged', 'Aged, 80 and over', 'Disease-Free Survival', 'Female', 'Humans', 'Lymphoma, B-Cell', 'Male', 'Middle Aged', 'Recurrence', 'Remission Induction', 'Skin Neoplasms', 'Survival Rate'] | 10,577,681 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E01.789.800.190', 'E05.318.740.998.300', 'N04.761.559.590.800.190', 'N05.715.360.575.575.800.190', 'N05.715.360.750.795.300', 'N06.850.520.830.998.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.386.480.150', 'C15.604.515.569.480.150', ... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Successful treatment by adding thalidomide to meglumine antimoniate in a case of refractory anthroponotic mucocutaneous leishmaniasis. | Mucosal leishmaniasis (ML) is mostly associated with Leishmania braziliensis; however, a few cases of Leishmania tropica induced mucocutaneous leishmaniasis have been reported. The standard treatment for leishmaniasis is pentavalent antimonials, but several other drugs for resistant cases have been proposed including a... | ['Antiprotozoal Agents', 'Humans', 'Iran', 'Leishmania tropica', 'Leishmaniasis, Mucocutaneous', 'Male', 'Meglumine Antimoniate', 'Nose', 'Thalidomide', 'Young Adult'] | 31,492,621 | [['D27.505.954.122.250.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.245.500.350'], ['B01.268.475.868.488.680'], ['C01.610.752.300.500.400.385', 'C01.610.858.560.400.385', 'C01.920.813.400.385', 'C17.800.838.775.560.400.385'], ['D02.033.800.813.550.800', 'D09.067.342.600.800', 'D09.853.813.550.800']... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Geographicals [Z]', 'Diseases [C]', 'Anatomy [A]', 'Named Groups [M]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
Recurrence and virulence of colonic diverticulitis in immunocompromised patients. | BACKGROUND: To evaluate the probability of recurrence and the virulence of colonic diverticulitis correlated with immunocompromised status.METHODS: Nine hundred thirty-one patients admitted in a single tertiary referral university hospital over a 14-year period were included. Patients were divided into 2 groups: group ... | ['Aged', 'Anti-Bacterial Agents', 'Diet', 'Digestive System Surgical Procedures', 'Diverticulitis, Colonic', 'Emergencies', 'Female', 'Follow-Up Studies', 'Humans', 'Immunocompromised Host', 'Length of Stay', 'Male', 'Middle Aged', 'Recurrence', 'Rest', 'Severity of Illness Index'] | 22,444,713 | [['M01.060.116.100'], ['D27.505.954.122.085'], ['G07.203.650.240'], ['E04.210'], ['C06.405.205.282.500.250', 'C06.405.469.158.587.500'], ['C23.550.291.781', 'N06.230.100.083', 'N06.850.376'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Multimodal microscopy for automated histologic analysis of prostate cancer. | BACKGROUND: Prostate cancer is the single most prevalent cancer in US men whose gold standard of diagnosis is histologic assessment of biopsies. Manual assessment of stained tissue of all biopsies limits speed and accuracy in clinical practice and research of prostate cancer diagnosis. We sought to develop a fully-auto... | ['Area Under Curve', 'Automation, Laboratory', 'Carcinoma', 'Histological Techniques', 'Humans', 'Male', 'Microscopy', 'Models, Biological', 'Models, Theoretical', 'Prostatic Neoplasms', 'Sensitivity and Specificity', 'Spectroscopy, Fourier Transform Infrared', 'Tissue Array Analysis'] | 21,303,560 | [['E05.318.740.200', 'G03.787.101', 'G07.690.725.064', 'N06.850.520.830.200'], ['E05.064', 'J01.897.104.416'], ['C04.557.470.200'], ['E01.370.225.750', 'E05.200.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.515', 'E05.595', 'H01.671.617.562'], ['E05.599.395'], ['E05.599'], ['C04.588.945.440.770'... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 |
Cycloaspeptides F and G, Cyclic Pentapeptides from a Cordyceps-colonizing isolate of Isaria farinosa. | Cycloaspeptides F (1) and G (2), two new cyclic pentapeptides, and the known cycloaspeptides A (3), C (4), and bisdethiodi(methylthio)hyalodendrin (5) have been isolated from the crude extract of the fungus Isaria farinosa that colonizes Cordyceps sinensis. The structures of 1 and 2 were elucidated primarily by NMR and... | ['Antineoplastic Agents', 'Cordyceps', 'Drug Screening Assays, Antitumor', 'HeLa Cells', 'Humans', 'Hypocreales', 'Molecular Structure', 'Nuclear Magnetic Resonance, Biomolecular', 'Peptides, Cyclic', 'Tibet'] | 19,572,613 | [['D27.505.954.248'], ['B01.300.107.501.220'], ['E01.370.225.500.388', 'E05.200.500.388', 'E05.242.417', 'E05.337.550.200'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.300.107.501'], ['G02.111.570', 'G02.466'], ['E05.196.867.519.550'], ['D04.345... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Modification of a model for cerebral ischemia in the cat: a new method to occlude the middle cerebral artery. | A modified method of occluding the middle cerebral artery (MCA) by inserting a tiny copper wire into the lumen of the vessel to make a model for cerebral ischemia in the cat is described. Of 22 rats, 4 were controls and the remaining 18 were divided into two groups. Bipolar electrocoagulation was used in 9 cats and cop... | ['Animals', 'Brain Ischemia', 'Cats', 'Cerebral Arteries', 'Disease Models, Animal', 'Evoked Potentials, Somatosensory'] | 2,755,579 | [['B01.050'], ['C10.228.140.300.150', 'C14.907.253.092'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['A07.015.114.228'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['G07.265.216.500.400', 'G11.561.200.500.400']] | ['Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The morbidity of a divided stoma compared to a loop colostomy in patients with anorectal malformation. | PURPOSE: Loop colostomies may contaminate the genitourinary (GU) tract in patients with anorectal malformations (ARM) owing to incomplete diversion of stool. Stoma complications are also thought to be higher with a loop versus divided colostomy. We sought to compare the morbidity, including urinary tract infections (UT... | ['Anorectal Malformations', 'Anus, Imperforate', 'Colostomy', 'Female', 'Humans', 'Infant, Newborn', 'Male', 'Rectal Fistula', 'Retrospective Studies', 'Surgical Stomas', 'Urinary Fistula', 'Urinary Tract Infections'] | 26,547,286 | [['C06.198.025', 'C16.131.314.047'], ['C06.198.050', 'C16.131.314.094'], ['E04.210.338.225', 'E04.579.338.225'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['C06.267.550.600', 'C06.405.469.471.600', 'C06.405.469.860.752', 'C23.300.575.185.550.600'], ['E05.318.372.500.500.500', 'E05.318.372.50... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A 10376 bp deletion of FECH gene responsible for erythropoietic protoporphyria. | Erythropoietic protoporphyria (EPP, MIM 177000) is an autosomal dominant disease with incomplete penetrance since the phenotypic expression requires coinheritance of a null allele and a wild-type low expressed allele of Ferrochelatase gene (FECH). In this study, we identify a peculiar mutation in a young Canadian patie... | ['Alleles', 'Child', 'Ferrochelatase', 'Humans', 'Male', 'Mutation', 'Polymorphism, Single Nucleotide', 'Promoter Regions, Genetic', 'Protoporphyria, Erythropoietic', 'Sequence Deletion'] | 17,888,693 | [['G05.360.340.024.340.030'], ['M01.060.406'], ['D08.811.520.500', 'D12.776.157.427.374.375.957', 'D12.776.556.579.374.375.617', 'D12.776.575.562'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G05.365.590'], ['G05.365.795.598'], ['G02.111.570.080.689.675', 'G05.360.080.689.675', 'G05.360.340.024.340.137.750.680'... | ['Phenomena and Processes [G]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Evaluation of photocatalytic activities of supported catalysts on NaX zeolite or activated charcoal. | This study aimed to evaluate the photocatalytic activity of ZnO and Nb2O5 catalysts, both supported on NaX zeolite and activated charcoal (AC). The synergistic effect between oxide and support and the influence of solution pH (3, 7 and 9) on photocatalytic degradation of reactive blue 5G (C.I. 222) were analyzed. The c... | ['Azo Compounds', 'Catalysis', 'Charcoal', 'Coloring Agents', 'Niobium', 'Oxides', 'Photolysis', 'Ultraviolet Rays', 'Zeolites', 'Zinc Oxide'] | 23,969,282 | [['D02.172'], ['G02.130'], ['D01.268.150.150'], ['D27.720.233'], ['D01.268.556.615', 'D01.268.956.687', 'D01.552.544.615'], ['D01.248.497.158.685', 'D01.650.550'], ['G02.740.685'], ['G01.358.500.505.650.891', 'G01.590.540.891', 'G01.750.250.650.891', 'G01.750.750.659', 'G01.750.770.578.891', 'G16.500.275.063.725.525.60... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Chicken IgL variable region gene conversions display pseudogene donor preference and 5' to 3' polarity. | Chicken immunoglobulin variable region diversity is generated during B-cell development in the bursa of Fabricius by intrachromosomal gene conversion, resulting in the replacement of sequence blocks within the unique rearranged VL1 and VH1 genes with homologous sequences derived from V region pseudogene segments (psi V... | ['Animals', 'Base Sequence', 'Cells, Cultured', 'Chickens', 'Exons', 'Gene Conversion', 'Genes, Immunoglobulin', 'Immunoglobulin Light Chains', 'Immunoglobulin Variable Region', 'Molecular Sequence Data', 'Pseudogenes', 'Sequence Homology, Nucleic Acid'] | 2,113,879 | [['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A11.251'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['G05.360.340.024.340.137.232'], ['G05.728.615.475'], ['G05.360.340.024.340.335', 'G12.500.299'], ['D12.776.124.486.485.705.750', 'D12.776.124.790.651.705.750', 'D12.776.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Long-term health investment when people underestimate their adaptation to old age-related health problems. | This paper explores in a two-period model the economic implications of people's tendency to underestimate their ability to adapt to age-related health problems. We model this misperception by assuming that the individual underestimates his future subjective health. Under standard assumptions, we show that, when people ... | ['Adaptation, Physiological', 'Adaptation, Psychological', 'Aging', 'Health Behavior', 'Health Status', 'Humans'] | 23,271,348 | [['G07.025', 'G16.012.500'], ['F01.058'], ['G07.345.124'], ['F01.145.488'], ['I01.240.425', 'N01.224.425', 'N06.850.505.400.425'], ['B01.050.150.900.649.313.988.400.112.400.400']] | ['Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
MRI demonstration of the effect of neoadjuvant radiotherapy on rectal carcinoma. | BACKGROUND AND PURPOSE: In patients with locally advanced rectal cancer, neoadjuvant long course (45-54 Gy in 25-30 fractions) chemoradiotherapy (CRT) may reduce tumour size and result in downstaging. In patients with primary resectable tumour short course (25 Gy in 5 fractions) radiotherapy (SCRT) reduces local recurr... | ['Adult', 'Aged', 'Aged, 80 and over', 'Carcinoma', 'Female', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Neoadjuvant Therapy', 'Rectal Neoplasms', 'Treatment Outcome'] | 17,851,843 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C04.557.470.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['M01.060.116.630'], ['E02.186.450'], ['C04.588.274.476.411.307.790', 'C06.301.371.411.307.790', 'C06.405.249.411.307.790', 'C06.405.469.491.307.790', 'C06.405.4... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A service-oriented grid infrastructure for biomedical data and compute services. | Service-oriented Grid technologies are increasingly utilized for the realization of future biomedical IT infrastructures since they offer unprecedented opportunities for the integration of advanced analysis and simulation applications as well as distributed heterogeneous data sources and information systems. The Europe... | ['Computational Biology', 'Database Management Systems', 'Databases, Factual', 'Information Storage and Retrieval', 'Internet', 'Molecular Biology', 'User-Computer Interface'] | 17,695,748 | [['H01.158.273.180', 'L01.313.124'], ['L01.224.068', 'L01.224.900.280', 'N04.452.515.110'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['L01.313.500.750.280', 'L01.470'], ['L01.224.230.110.500'], ['H01.158.201.636', 'H01.158.273.343.595', 'H01.181.122.650'], ['L01.224.900.910']] | ['Disciplines and Occupations [H]', 'Information Science [L]', 'Health Care [N]'] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Enhancement of the properties of a drug by mono-deuteriation: reduction of acid-catalysed formation of a gut-motilide enol ether from 8-deuterio-erythromycin B. | Erythromycin B is structurally very similar to erythromycin A, and also shares its clinically important antibacterial activity. Its potential advantage is that it is much more stable to acid. Both compounds are susceptible to 6-9-enol ether formation, involving loss of a proton from C-8. The enol ethers lack antibacter... | ['Alcohols', 'Anti-Bacterial Agents', 'Catalysis', 'Erythromycin', 'Ethers', 'Gram-Negative Bacteria', 'Gram-Positive Bacteria', 'Hydrogen-Ion Concentration', 'Microbial Sensitivity Tests', 'Molecular Conformation', 'Oxidation-Reduction'] | 27,273,525 | [['D02.033'], ['D27.505.954.122.085'], ['G02.130'], ['D02.540.576.500.992'], ['D02.355'], ['B03.440'], ['B03.510'], ['G02.300'], ['E01.370.225.875.595', 'E05.200.875.595', 'E05.337.550.400'], ['G02.111.570.820'], ['G02.700', 'G03.295.531']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Modeling the anti-CEA antibody combining site by homology and conformational search. | A model for an antibody specific for the carcinoembryonic antigen (CEA) has been constructed using a method which combines the concept of canonical structures with conformational search. A conformational search technique is introduced which couples random generation of backbone loop conformations to a simulated anneali... | ['Amino Acid Sequence', 'Antibodies', 'Binding Sites, Antibody', 'Carcinoembryonic Antigen', 'Computer Simulation', 'Models, Molecular', 'Molecular Sequence Data'] | 1,438,186 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D12.776.124.486.485.114', 'D12.776.124.790.651.114', 'D12.776.377.715.548.114'], ['G02.111.570.060.425.079', 'G02.111.570.120.408', 'G12.122.232', 'G12.125'], ['D12.776.395.550.200.210', 'D12.776.543.550.200.210', 'D23.050.285.329', 'D23.050.301.350.210', 'D23.101.140.300'... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Using tele-emergency to avoid patient transfers in rural emergency departments: An assessment of costs and benefits. | Introduction Tele-emergency can address several challenges facing emergency departments in rural areas. The purpose of this paper is to (a) examine the rates of avoided transfers in rural emergency departments that adopted tele-emergency applications; and (b) estimate the costs and benefits of using tele-emergency to a... | ['Cost-Benefit Analysis', 'Emergency Service, Hospital', 'Female', 'Hospitals, Rural', 'Humans', 'Male', 'Patient Transfer', 'Rural Health Services', 'Rural Population', 'South Dakota', 'Telemedicine'] | 29,278,984 | [['N03.219.151.125'], ['N02.278.216.500.968.336', 'N02.421.297.195', 'N04.452.442.452.422.336'], ['N02.278.421.518'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.760.169.624', 'E02.760.400.630', 'N02.421.585.169.624', 'N02.421.585.400.630', 'N04.590.233.727.210.624'], ['N02.421.816'], ['N01.600.725'], ['Z01.... | ['Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Disciplines and Occupations [H]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 |
Aversiveness of denatonium saccharide and quinine in grasshopper mice Onychomys leukogaster. | The responses toward denatonium saccharide and quinine by three rodent species differ from those exhibited by humans. This study measured the relative aversiveness of these two compounds in grasshopper mice (Onychomys leucogaster) to determine if this species responded similarly to or differently from these other roden... | ['Animals', 'Discrimination, Psychological', 'Drinking Behavior', 'Mice', 'Muridae', 'Quaternary Ammonium Compounds', 'Quinine', 'Taste'] | 2,717,362 | [['B01.050'], ['F02.463.593.257'], ['F01.145.317'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.150.900.649.313.992.635'], ['D01.625.062.500', 'D02.092.877', 'D02.675.276'], ['D03.132.206.719', 'D03.605.687.762', 'D03.633.100.810.762'], ['F02.830.816.724', 'G11.561.790.724']] | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Estimating forest canopy cover by combining spaceborne ICESat-GLAS waveforms and mul- tispectral Landsat-TM images]. | The spatial distribution of forest canopy cover is a critical indicator for evaluating the forest productivity and decomposition rates. With the Wangqing Forest Region in Jilin Province of China as the study area, this study first estimated the forest canopy cover using spaceborne LiDAR IC- ESat-GLAS waveforms and Land... | ['China', 'Environmental Monitoring', 'Forests', 'Linear Models', 'Neural Networks, Computer', 'Satellite Imagery', 'Trees'] | 26,572,016 | [['Z01.252.474.164'], ['N06.850.460.350.080', 'N06.850.780.375'], ['G16.500.275.157.437', 'N06.230.124.343'], ['E05.318.740.500.500', 'E05.318.740.750.425', 'E05.599.835.750', 'N05.715.360.750.530.460', 'N05.715.360.750.695.460', 'N06.850.520.830.500.500', 'N06.850.520.830.750.425'], ['G17.485', 'L01.224.050.375.605'],... | ['Geographicals [Z]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 |
Design and fabrication development of a micro flow heated channel with measurements of the inside micro-scale flow and heat transfer process. | The current work provides a design and fabrication technique for a micro channel system that can provide a uniform heat flux boundary condition on the channel wall and a well insulation on the wall to prevent heat loss from the channel to the outside ambient. Therefore, detailed micro-scale flow and heat transfer proce... | ['Equipment Design', 'Equipment Failure Analysis', 'Flow Injection Analysis', 'Heating', 'Hot Temperature', 'Microfluidic Analytical Techniques', 'Reproducibility of Results', 'Sensitivity and Specificity', 'Thermal Conductivity', 'Thermography', 'Transducers'] | 15,142,581 | [['E05.320'], ['E05.325.192'], ['E05.196.460'], ['N06.230.150.300'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.775.710.380', 'N06.230.300.100.725.232', 'N06.230.300.100.725.710.380'], ['E05.588.465'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['E05.318.370.8... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Epidermal growth factor can replace thymic mesenchyme in induction of embryonic thymus morphogenesis in vitro. | The thymus is surrounded by a thin layer of mesenchyme and the epithelial-mesenchymal interaction is known to be essential for the thymus development. To clarify the roles of mesenchyme in the thymus lobule formation that occurs around embryonic days 14-15 in vivo, we set up a three-dimensional organ culture system. Th... | ['Amino Acid Sequence', 'Animals', 'Collagen', 'Culture Media, Conditioned', 'Drug Combinations', 'Embryonic Induction', 'Epidermal Growth Factor', 'Laminin', 'Mesoderm', 'Mice', 'Mice, Inbred ICR', 'Molecular Sequence Data', 'Morphogenesis', 'Organ Culture Techniques', 'Proteoglycans', 'Thymus Gland', 'Transforming Gr... | 8,625,963 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D05.750.078.280', 'D12.776.860.300.250'], ['D27.720.470.305.250', 'E07.206.250'], ['D26.310'], ['G04.085.300', 'G04.152.300', 'G07.345.500.100.250', 'G07.345.500.325.180.750', 'G08.686.784.170.104.750'], ['D06.472.317.350', 'D12.644.276.382.500', 'D12.776.467.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Recommendations for development of an emergency plan for in vitro fertilization programs: a committee opinion. | All in vitro fertilization (IVF) programs and clinics should have a plan to protect fresh and cryopreserved human tissue (embryos, oocytes, sperm) and to provide for continuation of patient care in the event of an emergency or natural disaster. This document was reviewed and affirmed by the Practice Committee in 2011. | ['Advisory Committees', 'Continuity of Patient Care', 'Cryopreservation', 'Disasters', 'Embryo, Mammalian', 'Emergency Medical Services', 'Expert Testimony', 'Female', 'Fertilization in Vitro', 'Forms and Records Control', 'Health Planning Guidelines', 'Humans', 'Male', 'Oocytes', 'Practice Guidelines as Topic', 'Semen... | 22,537,383 | [['N03.706.742.500'], ['E02.760.169', 'N02.421.585.169', 'N04.590.233.727.210'], ['E01.370.225.500.620.760.160', 'E01.370.225.750.600.760.160', 'E02.792.156', 'E05.200.500.620.760.160', 'E05.200.750.600.760.160', 'E05.760.156'], ['N06.230.100'], ['A16.254'], ['N02.421.297'], ['I01.880.604.583.232', 'N03.706.535.253'], ... | ['Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Skeletal muscle water and electrolytes following prolonged dehydrating exercise. | We studied if dehydrating exercise would reduce muscle water (H2Omuscle ) and affect muscle electrolyte concentrations. Vastus lateralis muscle biopsies were collected prior, immediately after, and 1 and 4 h after prolonged dehydrating exercise (150 min at 33 ± 1 °C, 25% ± 2% humidity) on nine endurance-trained cyclist... | ['Adolescent', 'Adult', 'Bicycling', 'Body Water', 'Dehydration', 'Electrolytes', 'Exercise', 'Extracellular Fluid', 'Fluid Shifts', 'Humans', 'Intracellular Fluid', 'Male', 'Muscle, Skeletal', 'Plasma Volume', 'Quadriceps Muscle', 'Sweat', 'Water-Electrolyte Imbalance', 'Young Adult'] | 25,199,922 | [['M01.060.057'], ['M01.060.116'], ['I03.450.642.845.140'], ['A12.207.200'], ['C18.452.950.179', 'C23.550.274'], ['D01.248'], ['G11.427.410.698.277', 'I03.350'], ['A11.284.295.260', 'A12.207.270'], ['G07.313'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.284.430.429', 'A11.284.835.450', 'A12.207.515'], ['A02... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
The terpolymer produced by Azotobacter chroococcum 7B: effect of surface properties on cell attachment. | The copolymerization of poly(3-hydroxybutyrate) (PHB) is a promising trend in bioengineering to improve biomedical properties, e.g. biocompatibility, of this biodegradable polymer. We used strain Azotobacter chroococcum 7B, an effective producer of PHB, for biosynthesis of not only homopolymer and its main copolymer, p... | ['Azotobacter', 'Biocompatible Materials', 'Biopolymers', 'Calorimetry, Differential Scanning', 'Cell Adhesion', 'Cell Proliferation', 'Magnetic Resonance Spectroscopy', 'Microscopy, Atomic Force', 'Molecular Weight'] | 23,468,935 | [['B03.440.400.425.625.050', 'B03.660.250.580.022'], ['D25.130', 'D27.720.102.130', 'J01.637.051.130'], ['D05.750.078', 'D25.720.099', 'J01.637.051.720.099'], ['E05.196.131.310', 'E05.196.370.310'], ['G04.022'], ['G04.161.750', 'G07.345.249.410.750'], ['E05.196.867.519'], ['E01.370.350.515.666.400', 'E05.595.666.400'],... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
A new measurement tool to consider for airborne pollutants evaluations using lichens. | An important factor affecting acquisition of pollution elements could be the lichen growth form. The Brunauer-Emmett-Teller theory approach has been used to determinate the specific area surface (BET-area) of solids by gas multilayer adsorption. Taking this standard method as a new tool, we measure the specific thallus... | ['Air Pollutants', 'Argentina', 'Environmental Monitoring', 'Lichens', 'Metals, Heavy'] | 30,937,743 | [['D27.888.284.101'], ['Z01.107.757.077'], ['N06.850.460.350.080', 'N06.850.780.375'], ['B01.300.340', 'B05.350'], ['D01.268.556', 'D01.552.544']] | ['Chemicals and Drugs [D]', 'Geographicals [Z]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Visualization of clear echocardiographic images with near field noise reduction technique: experimental study and clinical experience. | BACKGROUND: With transthoracic echocardiography, it is sometimes difficult to obtain a clear image of the apical portion of the heart because of noise near the transducer. To reduce this artifact, we have developed a new technique (near field noise reduction, NFNR) based on the digital filtering by using radiofrequency... | ['Echocardiography', 'Female', 'Humans', 'Image Enhancement', 'Male', 'Middle Aged', 'Phantoms, Imaging', 'Transducers'] | 9,657,406 | [['E01.370.350.130.750', 'E01.370.350.850.220', 'E01.370.370.380.220'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.600.350', 'L01.224.308.380'], ['M01.060.116.630'], ['E07.671'], ['E07.305.812']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Information Science [L]', 'Named Groups [M]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Biodiversity of amoebae and amoebae-resisting bacteria in a drinking water treatment plant. | The complex ecology of free-living amoebae (FLA) and their role in spreading pathogenic microorganisms through water systems have recently raised considerable interest. In this study, we investigated the presence of FLA and amoebae-resisting bacteria (ARB) at various stages of a drinking water plant fed with river wate... | ['Amoeba', 'Animals', 'Bacteria', 'Biodiversity', 'Coculture Techniques', 'DNA, Bacterial', 'DNA, Protozoan', 'DNA, Ribosomal', 'Disinfectants', 'Disinfection', 'Ecosystem', 'Ozone', 'Phylogeny', 'RNA, Ribosomal, 16S', 'RNA, Ribosomal, 18S', 'Rivers', 'Sequence Analysis, DNA', 'Sequence Homology', 'Water Microbiology',... | 18,637,950 | [['B01.046.500.100.700.089'], ['B01.050'], ['B03'], ['G16.500.275.157.049', 'N06.230.124.049'], ['E05.481.500.374'], ['D13.444.308.212'], ['D13.444.308.442'], ['D13.444.308.475'], ['D27.505.954.122.425', 'D27.720.274'], ['N06.850.780.200.450.850.375'], ['G16.500.275.157', 'N06.230.124'], ['D01.362.670.600'], ['G05.697'... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Information Science [L]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Possible role of the M?ller cell in uptake and metabolism of glutamate in the mammalian outer retina. | It is not known how glutamate released synaptically in the outer plexiform layer of the retina is inactivated. Since there is no extracellular enzymatic degradation, glutamate released from photoreceptors is taken up intracellularly by at least one of the three transporters known, and metabolized by a glutamate degradi... | ['Amino Acid Transport System X-AG', 'Animals', 'Carrier Proteins', 'Glutamate-Ammonia Ligase', 'Glutamic Acid', 'Glycoproteins', 'Immunoenzyme Techniques', 'Microscopy, Immunoelectron', 'Neuroglia', 'Photoreceptor Cells', 'Rats', 'Retina'] | 9,068,840 | [['D12.776.157.530.200.249.500', 'D12.776.157.530.937.250', 'D12.776.543.585.200.249.500', 'D12.776.543.585.937.250'], ['B01.050'], ['D12.776.157'], ['D08.811.464.259.200.600'], ['D12.125.067.625.349', 'D12.125.119.409.349', 'D12.125.427.300'], ['D09.400.430', 'D12.776.395'], ['E05.478.566.350', 'E05.478.583.400', 'E05... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Acute aortic regurgitation due to localized aortic dissection adjacent to the commissure of the aortic valve]. | A 78-year-old male with a sudden loss of consciousness and chest pain was transferred to our hospital. He presented heart failure due to severe aortic regurgitation. Cardiac ultrasonography and computed tomography (CT) scanning did not lead to an established diagnosis of acute aortic dissection. Aortic valve replacemen... | ['Acute Disease', 'Aged', 'Aneurysm, Dissecting', 'Aortic Aneurysm', 'Aortic Valve', 'Aortic Valve Insufficiency', 'Heart Valve Prosthesis Implantation', 'Humans', 'Male'] | 12,136,581 | [['C23.550.291.125'], ['M01.060.116.100'], ['C14.907.055.050'], ['C14.907.055.239', 'C14.907.109.139'], ['A07.541.510.110'], ['C14.280.484.048.500'], ['E04.100.376.485', 'E04.650.410', 'E04.928.220.410'], ['B01.050.150.900.649.313.988.400.112.400.400']] | ['Diseases [C]', 'Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
South African podiatry students' perceptions of feedback given as part of clinical training. | Background: As part of their clinical training podiatry students spend time in clinical settings treating patients under the supervision of qualified podiatrists. The role and purpose of feedback during such clinical training is to improve students' knowledge, skills and behaviour. Feedback is an integral part of the l... | ['Cross-Sectional Studies', 'Formative Feedback', 'Humans', 'Podiatry', 'Students, Medical'] | 29,988,740 | [['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['F02.784.629.529.223'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H02.696'], ['M01.848.769.602']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Named Groups [M]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Percutaneous microcompression of the trigeminal ganglion for trigeminal neuralgia. | Fifty patients were treated for trigeminal neuralgia by percutaneous microcompression of the trigeminal ganglion. A No. 4 Fogarty balloon catheter was inserted under brief general anesthesia, using biplane fluoroscopy. This procedure is essentially a percutaneous simplication of the older Taarnh?j-Sheldon-Pudenz operat... | ['Adolescent', 'Adult', 'Aged', 'Catheterization', 'Female', 'Humans', 'Male', 'Microsurgery', 'Middle Aged', 'Trigeminal Nerve', 'Trigeminal Neuralgia'] | 6,631,493 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['E02.148', 'E05.157'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.494', 'E05.591.580'], ['M01.060.116.630'], ['A08.800.800.120.760'], ['C07.465.299.625.500.700', 'C10.292.319.625.700.700']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Effect of pro-inflammatory and immunoregulatory cytokines on human tenocytes. | Tendon injury induces a local inflammatory response, characterized by the induction of pro-inflammatory cytokines. The aim of the present study was to analyze the effects of TNFalpha, IL-6 and IL-10 on key parameters of tendon homeostasis. Cultured primary human tenocytes were treated with the recombinant cytokines IL-... | ['Adult', 'Aged', 'Aged, 80 and over', 'Cells, Cultured', 'Collagen Type I', 'Elastin', 'Female', 'Humans', 'Interleukin-10', 'Interleukin-1beta', 'Interleukin-6', 'Male', 'Matrix Metalloproteinase 1', 'Middle Aged', 'Suppressor of Cytokine Signaling 1 Protein', 'Suppressor of Cytokine Signaling 3 Protein', 'Suppressor... | 20,127,972 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['A11.251'], ['D05.750.078.280.300.100', 'D12.776.860.300.250.300.100'], ['D05.750.078.421', 'D12.776.860.300.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.465.510', 'D12.776.467.374.465.510', 'D23.529.374.465.510'], ['D12.644.2... | ['Named Groups [M]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A case of Graves' ophthalmopathy associated with pembrolizumab (Keytruda) therapy. | We present the first reported case of Graves' orbitopathy induced by pembrolizumab, a new FDA-approved drug used for the treatment of multiple refractory solid tumors and classic Hodgkin lymphoma. Pembrolizumab elicits T-lymphocyte proliferation; we suspect that thyroid eye disease may result in some cases. | ['Antibodies, Monoclonal, Humanized', 'Antineoplastic Agents, Immunological', 'Graves Ophthalmopathy', 'Humans', 'Male', 'Middle Aged'] | 29,626,663 | [['D12.776.124.486.485.114.224.060', 'D12.776.124.790.651.114.224.060', 'D12.776.377.715.548.114.224.200'], ['D27.505.954.248.384'], ['C11.270.240', 'C11.675.349.500.500', 'C16.320.347', 'C19.874.283.605.500', 'C19.874.397.370.500', 'C20.111.555.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Impact of Predilation Before Transcatheter Aortic Valve Implantation with New-Generation Devices. | BACKGROUND: Significant aortic stenosis can be effectively treated with transcatheter aortic valve implantation (TAVI) in patients at high or intermediate surgical risk. Predilation is often performed to facilitate TAVI implantation, but its risk-benefit balance with new-generation devices is detabed. We aimed to appra... | ['Aged', 'Aged, 80 and over', 'Aortic Valve', 'Aortic Valve Insufficiency', 'Aortic Valve Stenosis', 'Balloon Valvuloplasty', 'Echocardiography', 'Female', 'Heart Valve Prosthesis', 'Humans', 'Italy', 'Male', 'Operative Time', 'Prospective Studies', 'Prosthesis Design', 'Recovery of Function', 'Risk Factors', 'Time Fac... | 30,711,476 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['A07.541.510.110'], ['C14.280.484.048.500'], ['C14.280.484.048.750', 'C14.280.955.249'], ['E02.148.108', 'E05.157.125'], ['E01.370.350.130.750', 'E01.370.350.850.220', 'E01.370.370.380.220'], ['E07.695.310'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.542.489'... | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Functional and evolutionary insights from the genomes of three parasitoid Nasonia species. | We report here genome sequences and comparative analyses of three closely related parasitoid wasps: Nasonia vitripennis, N. giraulti, and N. longicornis. Parasitoids are important regulators of arthropod populations, including major agricultural pests and disease vectors, and Nasonia is an emerging genetic model, parti... | ['Animals', 'Arthropods', 'Biological Evolution', 'DNA Methylation', 'DNA Transposable Elements', 'Female', 'Gene Transfer, Horizontal', 'Genes, Insect', 'Genetic Speciation', 'Genetic Variation', 'Genome, Insect', 'Host-Parasite Interactions', 'Insect Proteins', 'Insect Viruses', 'Insecta', 'Male', 'Molecular Sequence... | 20,075,255 | [['B01.050'], ['B01.050.500.131'], ['G05.045', 'G16.075'], ['G02.111.035.538.161', 'G02.111.218', 'G03.059.538.161', 'G05.206'], ['D13.444.308.520', 'G02.111.570.080.708.330.200', 'G05.360.080.708.330.200', 'G05.360.340.024.425.200'], ['G05.728.390'], ['G05.360.340.024.340.340', 'G05.360.340.357.500'], ['G05.045.350', ... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Aspergillus fumigatus and mesophilic moulds in air in the surrounding environment downwind of non-hazardous waste landfill sites. | Non-hazardous waste landfilling has the potential to release biological agents into the air, notably mould spores. Some species, such as Aspergillus fumigatus, may be a cause of concern for at-risk nearby residents. However, air concentration in the surrounding environment of non-hazardous waste landfill sites is poorl... | ['Air Microbiology', 'Air Pollutants', 'Environmental Monitoring', 'Fungi', 'Hazardous Waste Sites', 'Wind'] | 26,915,642 | [['H01.158.273.540.274.110', 'N06.850.425.110'], ['D27.888.284.101'], ['N06.850.460.350.080', 'N06.850.780.375'], ['B01.300'], ['N06.850.780.200.800.800.900.449.500', 'N06.850.860.510.900.700.500'], ['G16.500.175.249.200', 'G16.500.275.063.725.154.200', 'G16.500.750.775.780', 'N06.230.132.644.875', 'N06.230.300.100.150... | ['Disciplines and Occupations [H]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Improving Medicare's Hospital Compare Mortality Model. | OBJECTIVE: To improve the predictions provided by Medicare's Hospital Compare (HC) to facilitate better informed decisions regarding hospital choice by the public.DATA SOURCES/SETTING: Medicare claims on all patients admitted for Acute Myocardial Infarction between 2009 through 2011.STUDY DESIGN: Cohort analysis using ... | ['Aged', 'Bayes Theorem', 'Cohort Studies', 'Fee-for-Service Plans', 'Health Services Research', 'Hospital Mortality', 'Hospitals', 'Humans', 'Medicare', 'Models, Statistical', 'Myocardial Infarction', 'United States'] | 26,987,446 | [['M01.060.116.100'], ['E05.318.740.600.200', 'N05.715.360.750.625.150', 'N06.850.520.830.600.200'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['N03.219.442.195', 'N03.219.521.710.305.090', 'N04.452.758.745.225'], ['H01.770.644.145.360', 'N03.349.380', 'N05.425'], ['E05.318.308.985.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
Comparison of two surgical approaches for the treatment of primary spontaneous pneumothorax*. | AIM: The authors report a retrospective study on surgical treatment of primary spontaneous pneumothorax (PSP). Surgical approaches by Videoassisted axillary mini-thoracothomy (VAMT) and three-port VATS (t-VATS) are compared. Mean post-operative stay (MPS) and ipsilateral recurrence rate (IRR) are assessed. Secondary en... | ['Adolescent', 'Adult', 'Axilla', 'Drainage', 'Female', 'Follow-Up Studies', 'Humans', 'Length of Stay', 'Male', 'Pain, Postoperative', 'Pneumothorax', 'Retrospective Studies', 'Secondary Prevention', 'Thoracic Surgery, Video-Assisted', 'Treatment Outcome'] | 24,979,102 | [['M01.060.057'], ['M01.060.116'], ['A01.378.800.090'], ['E02.309', 'E04.237'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.760.400.480', 'N02.421.585.400.480'], ['C23.550.767.700', 'C23.888.592.612.832'], ['C08.528.77... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Healthy humans with a narrow upper airway maintain patency during quiet breathing by dilating the airway during inspiration. | A patent upper airway is essential for survival. Increased age, obesity and some upper airway anatomical features are associated with failure to maintain upper airway patency during sleep, leading to obstructive sleep apnoea. However, many healthy subjects with these risk factors do not develop this condition. The aim ... | ['Adult', 'Aged', 'Aging', 'Body Mass Index', 'Female', 'Humans', 'Linear Models', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Models, Biological', 'Respiration', 'Respiratory System', 'Young Adult'] | 25,217,376 | [['M01.060.116'], ['M01.060.116.100'], ['G07.345.124'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.500', 'E05.318.740.750.425', 'E05.599.835.750', 'N05.715.360.750.530.460', 'N05.715.360.750.695.460', '... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Changes in mutagenicity of protein pyrolyzates by reaction with nitrite. | Pyrolyzates of protein and related materials were treated with nitrite under acidic conditions, and the mutagenic activity toward Salmonella tester strains was determined. After treatment with nitrite in acidic solution, casein pyrolyzate, an extract of roasted chicken meat, tobacco-smoke condensate and some aromatic a... | ['Genetic Techniques', 'Hot Temperature', 'Mutagens', 'Nitrites', 'Proteins', 'Salmonella typhimurium', 'Smoke'] | 362,194 | [['E05.393'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.775.710.380', 'N06.230.300.100.725.232', 'N06.230.300.100.725.710.380'], ['D27.888.569.468'], ['D01.248.497.158.635', 'D01.625.600.600', 'D02.633'], ['D12.776'], ['B03.440.450.425.800.200.825', 'B03.660.250.150.710.160.760'], ['D20.633.937']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Examining low bacterial dietary practice: a survey on low bacterial food. | Patients with haematological malignancies have periods of neutropenia caused by the disease process and subsequent treatments, during which time they are at an increased risk of developing life threatening infections. Historically, many measures have been initiated to protect patients during this time. One such measure... | ['Cooking', 'Europe', 'Food Microbiology', 'Food Service, Hospital', 'Health Care Surveys', 'Hematologic Neoplasms', 'Humans', 'Neutropenia', 'Opportunistic Infections', 'Practice Guidelines as Topic', 'Stem Cell Transplantation'] | 18,524,677 | [['J01.576.423.200.200'], ['Z01.542'], ['H01.158.273.540.274.332', 'J01.576.423.850.730.500.249.300', 'N06.850.425.200', 'N06.850.460.400.300', 'N06.850.601.500.249.300'], ['J01.576.423.500.300', 'N02.278.216.500.968.374', 'N02.421.242.472', 'N04.452.442.452.422.374'], ['E05.318.308.980.344', 'N03.349.380.210', 'N05.42... | ['Technology, Industry, and Agriculture [J]', 'Geographicals [Z]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 |
First steps towards a Zn/Co(III)sep-driven P450 BM3 reactor. | Cytochrome P450s are synthetically attractive hydroxylation catalysts. For cell-free applications, a constant supply of NAD(P)H can be very costly. Mediators such as Zn/Co(III)sep can be an alternative cofactor system to NAD(P)H. Several mutants of cytochrome P450 BM3 with improved electron transfer rate to Zn/Co(III)s... | ['Amino Acid Substitution', 'Bacterial Proteins', 'Coenzymes', 'Cytochrome P-450 Enzyme System', 'Enzymes, Immobilized', 'Mutant Proteins', 'NADPH-Ferrihemoprotein Reductase', 'Phenyl Ethers'] | 21,562,982 | [['E05.393.420.601.035', 'G05.558.109'], ['D12.776.097'], ['D08.211'], ['D08.244.453', 'D08.811.682.690.708.170', 'D12.776.422.220.453'], ['D08.811.180', 'D12.776.463.500'], ['D12.776.602'], ['D08.811.682.608.191.500'], ['D02.355.726', 'D02.455.426.559.389.657.654']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mucociliary flow in the canine frontal sinus. | The mucociliary flow in the frontal sinus of dogs is in a spiral pattern from medial to lateral. The final evacuation of mucus is through the ostium positioned anteriorly. Mucus flow rate is most rapid in the areas of the ostium and slowest in the area of the intersinus septum. Mucus flow patterns remain the same despi... | ['Animals', 'Cilia', 'Dogs', 'Frontal Sinus', 'Nasal Mucosa', 'Nasal Septum', 'Secretory Rate'] | 6,824,286 | [['B01.050'], ['A11.284.180.165'], ['B01.050.150.900.649.313.750.250.216.200'], ['A04.531.621.387'], ['A04.531.520', 'A04.760.600', 'A10.615.550.760.600'], ['A04.531.591'], ['G03.857']] | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The perineurium of the adult housefly: ultrastructure and permeability to lanthanum. | The ultrastructure of the perineurial cells of Musca overlying the first optic neuropile was examined by transmission electron microscopy. These cells are somewhat similar to those of other insects but cytoplasmic flanges seem to be absent, and mitochondria are relatively large and sinuous. The intercellular channel sy... | ['Animals', 'Endoplasmic Reticulum', 'Houseflies', 'Lanthanum', 'Microscopy, Electron', 'Mitochondria', 'Nervous System', 'Neurons', 'Permeability'] | 7,237,533 | [['B01.050'], ['A11.284.430.214.190.875.248'], ['B01.050.500.131.617.720.500.500.750.642.470'], ['D01.268.558.362.500', 'D01.552.550.399.500'], ['E01.370.350.515.402', 'E05.595.402'], ['A11.284.430.214.190.875.564', 'A11.284.835.626'], ['A08'], ['A08.675', 'A11.671'], ['G02.723']] | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Apoptosis and catastrophic cell death in benzo[a]pyrene-transformed human breast epithelial cells. | Apoptosis and mitotic death, bi- and multinucleation, giant cells and micronucleation were investigated in human breast epithelial cell lines transformed by benzo[a]pyrene (BP) (BP1, BP1-E and BP1-E1 cells) and in BP1 cells transfected with the c-Ha-ras oncogene (BP1-Tras cells). Since BP induces apoptosis and the abno... | ['Apoptosis', 'Benzo(a)pyrene', 'Breast', 'Cell Death', 'Cell Line, Transformed', 'Cell Nucleus', 'Cell Transformation, Neoplastic', 'Epithelial Cells', 'Genes, ras', 'Humans', 'Mitosis', 'Mitotic Index', 'Transfection'] | 10,656,492 | [['G04.146.954.035'], ['D02.455.426.559.847.799.306.300', 'D04.615.799.306.300'], ['A01.236'], ['G04.146'], ['A11.251.210.172'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['C04.697.098.500', 'C23.550.727.098.500'], ['A11.436'], ['G05.360.340.024.340.375.500.791.550'], ['B01.050.150.900.649.313.988.400.112.400... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
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