Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Activation of B cells by 1 microm particulate lysozyme or peptides: a Th-dependent pathway requiring CD40-CD40 ligand interaction. | Many antigens encountered by the immune system are included in complex structures such as bacteria or parasites. We previously developed an in vivo model to study the immunogenicity of particulate antigens, based on covalent linkage of proteins or peptides to 1 microm latex particles and showed that these antigens cann... | ['Aluminum Hydroxide', 'Animals', 'Antibody Formation', 'Antibody Specificity', 'B-Lymphocytes', 'CD40 Antigens', 'CD40 Ligand', 'Cells, Cultured', 'Epitopes', 'Female', 'Hemocyanins', 'Lymphocyte Activation', 'Lymphocyte Cooperation', 'Membrane Glycoproteins', 'Mice', 'Mice, Inbred BALB C', 'Mice, Inbred DBA', 'Micros... | 9,723,697 | [['D01.045.250.050', 'D01.056.037', 'D01.248.497.158.459.075'], ['B01.050'], ['G12.450.050.370.250'], ['G12.100'], ['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['D12.776.465.750', 'D12.776.543.750.705.852.760.097', 'D23.050.301.264.051.140', 'D... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Associations among circulating sex hormones, insulin-like growth factor, lipids, and mammographic density in postmenopausal women. | OBJECTIVE: Hormone therapy use has been positively associated with mammographic density in several studies. However, few studies have examined the association between endogenous hormone levels and mammographic density. Therefore, we evaluated the relationship of endogenous sex hormones, insulin-like growth factor (IGF)... | ['Aged', 'Breast', 'Female', 'Gonadal Steroid Hormones', 'Humans', 'Lipids', 'Mammography', 'Middle Aged', 'Obesity', 'Postmenopause', 'Somatomedins'] | 15,941,949 | [['M01.060.116.100'], ['A01.236'], ['D06.472.334.851'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D10'], ['E01.370.350.700.500'], ['M01.060.116.630'], ['C18.654.726.500', 'C23.888.144.699.500', 'E01.370.600.115.100.160.120.699.500', 'G07.100.100.160.120.699.500'], ['G08.686.157.500.625', 'G08.686.841.249.500.6... | ['Named Groups [M]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Oxytocin and the initiation of human parturition. IV. Plasma concentrations of oxytocin and 13,14-dihydro-15-keto-prostaglandin F2 alpha during induction of labor by artificial rupture of the membranes. | The influence of artificial rupture of the membranes on plasma levels of 13,14-dihydro-15-keto-prostaglandin F2 alpha (PGFM) and oxytocin was examined in 23 pregnant women at term. Serial blood samples were collected before and 15 minutes, 2 hours, 5 hours, and 8 hours after artificial rupture of the membranes. A signi... | ['Amnion', 'Cervix Uteri', 'Dinoprost', 'Female', 'Humans', 'Infant, Newborn', 'Labor, Induced', 'Labor, Obstetric', 'Oxytocin', 'Pregnancy', 'Prostaglandins F', 'Radioimmunoassay', 'Time Factors'] | 6,638,092 | [['A10.615.284.277', 'A16.254.750.277'], ['A05.360.319.679.256'], ['D10.251.355.255.550.400.200', 'D23.469.050.175.725.400.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['E04.520.252.968'], ['G08.686.784.769.326'], ['D06.472.699.631.692.433', 'D12.644.548.691.692.433'], ['G08.686.784.769'... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Serine phosphorylation of paxillin by heregulin-beta1: role of p38 mitogen activated protein kinase. | The mechanisms through which heregulin (HRG) regulates the progression of breast cancer cells to a more invasive phenotype are currently unknown. Recently we have shown that HRG treatment of breast cancer cells leads to the formation of lamellipodia/filopodia, and increased cell migration and invasiveness through the p... | ['Breast Neoplasms', 'Cell Adhesion', 'Cell Adhesion Molecules', 'Cytoskeletal Proteins', 'Female', 'Humans', 'Mitogen-Activated Protein Kinases', 'Neuregulin-1', 'Paxillin', 'Phosphoproteins', 'Phosphorylation', 'Serine', 'Signal Transduction', 'Tumor Cells, Cultured', 'p38 Mitogen-Activated Protein Kinases'] | 10,602,479 | [['C04.588.180', 'C17.800.090.500'], ['G04.022'], ['D12.776.395.550.200', 'D12.776.543.550.200', 'D23.050.301.350'], ['D12.776.220'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.913.696.620.682.700.567', 'D12.644.360.450', 'D12.776.476.450'], ['D12.644.276.860.550.750', 'D12.776.467.860.550.750', 'D12.77... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Some thoughts on Bateman's equation]. | The authors have investigated the characteristics of one of the basic equations of pharmacokinetics, Bateman's equation in the function of the differences between the absorption and elimination constants. | ['Humans', 'Intestinal Absorption', 'Models, Theoretical', 'Pharmacokinetics'] | 9,289,935 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['G03.015.500.374.500', 'G03.787.024.500.374.500', 'G07.203.650.372.500', 'G07.690.725.015.500.374.500', 'G10.261.353.500'], ['E05.599'], ['G03.787', 'G07.690.725']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Evaluation of the Biolog system for the identification of Bacillus anthracis. | The potential of the Biolog system for the identification of Bacillus anthracis was evaluated. In-house generated databases allowed the correct identification of 19 of 20 isolates of B. anthracis within 24 h. Five strains of the closely related B. cereus/thuringiensis group were misidentified as B. anthracis. For this ... | ['Bacillus anthracis', 'False Positive Reactions', 'Information Systems', 'Microbiological Techniques', 'Software'] | 7,766,114 | [['B03.300.390.400.158.218.151', 'B03.353.500.100.218.151', 'B03.510.100.100.218.151', 'B03.510.415.400.158.218.151', 'B03.510.460.410.158.218.151'], ['E01.354.506'], ['L01.313.500.750.300'], ['E01.370.225.875', 'E05.200.875'], ['L01.224.900']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
[Protective efficacy of 3 anesthetic methods with reference to surgical stress in children]. | Hormonal-metabolic stress responses have beyond doubt an effect on morbidity/mortality related to surgery. The present study med to determine which anaesthetic technique could afford the best protection in children, through analysis of the perioperative cortisol, prolactin and beta-endorphin plasma levels. Thirty-six y... | ['Anesthesia, General', 'Child', 'Child, Preschool', 'Humans', 'Hydrocortisone', 'Prolactin', 'Stress, Physiological', 'Surgical Procedures, Operative', 'beta-Endorphin'] | 9,033,826 | [['E03.155.197'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D04.210.500.745.745.654.600', 'D06.472.040.585.353.476', 'D06.472.040.585.478.392'], ['D06.472.699.322.576.773', 'D06.472.699.631.525.525', 'D12.644.548.691.525.525'], ['G07.775'], ['E04'], ['D06.472.699.327.935.2... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Reduction of maturation phenomenon in cerebral ischemia with CDP-choline-loaded liposomes. | PURPOSE: Cerebral ischemia represents a serious therapeutic challenge. We investigated the therapeutic efficacy of CDP-choline-loaded liposomes against cerebral ischemia. The determination of post-ischemic brain recovery by EEG analysis was carried out to evaluate the effect of CDP-choline-loaded liposomes with respect... | ['Animals', 'Blood-Brain Barrier', 'Brain Ischemia', 'Chemical Phenomena', 'Chemistry, Physical', 'Cytidine Diphosphate Choline', 'Drug Carriers', 'Electroencephalography', 'Freeze Fracturing', 'G(M1) Ganglioside', 'Lactates', 'Lipid Peroxidation', 'Liposomes', 'Male', 'Nootropic Agents', 'Rats', 'Rats, Wistar', 'Survi... | 10,644,072 | [['B01.050'], ['A07.035', 'A08.186.211.035'], ['C10.228.140.300.150', 'C14.907.253.092'], ['G02'], ['H01.181.529'], ['D02.092.877.883.333.130', 'D02.675.276.232.130', 'D03.383.742.686.246.150.180', 'D13.695.740.246.150.180', 'D13.695.827.232.150.180'], ['D26.255.260', 'E02.319.300.380'], ['E01.370.376.300', 'E01.370.40... | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 |
Prevalence of subclinical hepatic encephalopathy in cirrhotic patients in China. | AIM: Subclinical hepatic encephalopathy (SHE) is a common complication of liver diseases. The aim of this study was to find out the normal value of psychometric test and to investigate the prevalence of SHE in Chinese patients with stabilized hepatic cirrhosis.METHODS: Four hundred and nine consecutive cirrhotic patien... | ['Adult', 'Alcohol Drinking', 'China', 'Educational Status', 'Female', 'Hepatic Encephalopathy', 'Humans', 'Liver Cirrhosis', 'Male', 'Prevalence', 'Psychometrics', 'Reference Values', 'Risk Factors', 'Smoking'] | 15,285,027 | [['M01.060.116'], ['F01.145.317.269'], ['Z01.252.474.164'], ['N01.824.196'], ['C06.552.308.500.356', 'C10.228.140.163.360', 'C18.452.132.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C06.552.630', 'C23.550.355.412'], ['E05.318.308.985.525.750', 'N01.224.935.597.750', 'N06.850.505.400.975.525.750', 'N06.850.... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
The transcription factor Glass links eye field specification with photoreceptor differentiation in Drosophila. | Eye development requires an evolutionarily conserved group of transcription factors, termed the retinal determination network (RDN). However, little is known about the molecular mechanism by which the RDN instructs cells to differentiate into photoreceptors. We show that photoreceptor cell identity in Drosophila is cri... | ['Animals', 'DNA-Binding Proteins', 'Drosophila', 'Drosophila Proteins', 'Gene Expression Regulation, Developmental', 'Homeodomain Proteins', 'Neurogenesis', 'Photoreceptor Cells, Invertebrate', 'Retina'] | 26,952,983 | [['B01.050'], ['D12.776.260'], ['B01.050.500.131.617.720.500.500.750.310.250'], ['D12.776.093.500.462'], ['G05.308.310'], ['D12.776.260.400'], ['G04.152.912', 'G07.345.500.325.377.687', 'G08.686.784.170.450.500', 'G11.561.620'], ['A08.675.650.850.625.660', 'A08.675.650.915.937.650', 'A08.800.950.937.650', 'A09.371.729.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Self-Rehabilitation of a Captive American Crow at Binghamton Zoo. | The behavioral transition from an entirely unflighted-to-flighted, female yearling American crow (Corvus brachyrhynchos) in captivity in a specially designed exhibit was documented at the Binghamton Zoo at Ross Park in Binghamton, NY. Upon arrival, the focal crow had no complete primary feathers or retrices and had bee... | ['Animals', 'Animals, Zoo', 'Crows', 'Female', 'Flight, Animal', 'United States'] | 28,379,045 | [['B01.050'], ['B01.050.050.448'], ['B01.050.150.900.248.620.750.150'], ['G11.427.410.568.304', 'G11.427.410.698.416'], ['Z01.107.567.875']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
High platelet reactivity on aspirin in patients with acute ST elevation myocardial infarction. | BACKGROUND: Despite dual antiplatelet treatment, major ischemic events are common following ST elevation myocardial infarction (STEMI). We aimed to assess high platelet reactivity on aspirin (HPR-aspirin) and its association with P2Y12i (HPR-P2Y12i) during the acute phase of STEMI.METHODS: We included all consecutive p... | ['Acute Disease', 'Adenosine', 'Aspirin', 'Blood Platelets', 'Brain Ischemia', 'Cardiovascular Diseases', 'Clopidogrel', 'Female', 'Humans', 'Male', 'Middle Aged', 'Platelet Aggregation', 'Platelet Aggregation Inhibitors', 'Platelet Function Tests', 'Prasugrel Hydrochloride', 'Prospective Studies', 'Purinergic P2Y Rece... | 27,289,074 | [['C23.550.291.125'], ['D03.633.100.759.590.138', 'D13.570.583.138', 'D13.570.800.096'], ['D02.455.426.559.389.657.410.595.176'], ['A11.118.188', 'A15.145.229.188'], ['C10.228.140.300.150', 'C14.907.253.092'], ['C14'], ['D02.886.778.823.500.500', 'D03.383.725.849.500.500', 'D03.383.903.830.500.500', 'D03.633.100.928.50... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Mechanism of interaction between the general anesthetic halothane and a model ion channel protein, III: Molecular dynamics simulation incorporating a cyanophenylalanine spectroscopic probe. | A nitrile-derived amino acid, Phe(CN), has been used as an internal spectroscopic probe to study the binding of an inhalational anesthetic to a model membrane protein. The infrared spectra from experiment showed a blue-shift of the nitrile vibrational frequency in the presence of the anesthetic halothane. To interpret ... | ['Alanine', 'Anesthetics, General', 'Fluorescent Dyes', 'Halothane', 'Hydrogen', 'Ion Channels', 'Models, Molecular', 'Molecular Conformation', 'Movement', 'Mutation', 'Nitriles', 'Protein Binding', 'Spectrophotometry, Infrared', 'Vibration'] | 19,450,489 | [['D12.125.042'], ['D27.505.696.277.100.035', 'D27.505.954.427.210.100.035'], ['D27.720.233.348', 'D27.720.470.410.505.500'], ['D02.455.526.340'], ['D01.268.406', 'D01.362.340'], ['D12.776.157.530.400', 'D12.776.543.550.450', 'D12.776.543.585.400'], ['E05.599.595'], ['G02.111.570.820'], ['G07.568', 'G11.427.410'], ['G0... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[The medical education plans at the Complutense University, Medical School]. | The Medical Education of the Medical Faculty in the Complutense University of Madrid is analyzed since its double origin: The Cardinal Cisneros Constitutions, January 22-1510 and the Royal C?dula of King Charles III, February 24-1787, in which is created the Royal College of Surgery Saint Charles in Madrid. The Medical... | ['Cost-Benefit Analysis', 'Education, Continuing', 'Education, Medical', 'History, 16th Century', 'History, 17th Century', 'History, 18th Century', 'History, 19th Century', 'History, 20th Century', 'History, 21st Century', 'Schools, Medical', 'Spain', 'Teaching', 'Universities'] | 12,518,656 | [['N03.219.151.125'], ['I02.358.212'], ['I02.358.399'], ['K01.400.475.750'], ['K01.400.504.750'], ['K01.400.504.875'], ['K01.400.504.937'], ['K01.400.504.968'], ['K01.400.504.984'], ['I02.783.495.552', 'N02.278.020.578'], ['Z01.542.846'], ['I02.903'], ['I02.783.830', 'J03.832.830']] | ['Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Geographicals [Z]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 |
Titan's rotation reveals an internal ocean and changing zonal winds. | Cassini radar observations of Saturn's moon Titan over several years show that its rotational period is changing and is different from its orbital period. The present-day rotation period difference from synchronous spin leads to a shift of approximately 0.36 degrees per year in apparent longitude and is consistent with... | ['Atmosphere', 'Extraterrestrial Environment', 'Ice', 'Saturn', 'Spacecraft', 'Water', 'Wind'] | 18,356,521 | [['G16.500.275.063', 'N06.230.300.100'], ['G01.060.075.159', 'G16.500.275.240'], ['D01.045.250.875.400', 'D01.248.497.158.459.650.400', 'D01.650.550.925.400', 'G16.500.275.410', 'G16.500.750.775.342', 'N06.230.291'], ['G01.060.075.730.700.831'], ['J01.937.285.850.900'], ['D01.045.250.875', 'D01.248.497.158.459.650', 'D... | ['Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
[Food allergy: comparison of diagnostic techniques]. | Fourteen children affected with allergic disease, from 8 months to 7-years-old, were studied; three children had Bronchial asthma, one child Bronchial asthma and rhinitis, one child recurrent laryngospasm, six children atopic dermatitis, two children diarrhoea, one abdominal pain. In all patients cow's milk and egg wer... | ['Asthma', 'Child', 'Child, Preschool', 'Dermatitis, Atopic', 'Enzyme-Linked Immunosorbent Assay', 'Female', 'Food Hypersensitivity', 'Humans', 'Immunoglobulin E', 'Infant', 'Male', 'Rhinitis, Allergic, Perennial'] | 7,643,816 | [['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['M01.060.406'], ['M01.060.406.448'], ['C16.320.850.210', 'C17.800.174.193', 'C17.800.815.193', 'C17.800.827.210', 'C20.543.480.343'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Renal capsule transplantations to assay skeletal angiogenesis. | Renal capsule transplantation is a very helpful method to grow embryonic tissues or tumors in a vascular environment, allowing long-term engraftment and biological analyses. This chapter describes the surgical procedure for the transplantation of embryonic skeletal elements in the renal capsule of adult mice and points... | ['Animals', 'Bone Development', 'Bone and Bones', 'Bowman Capsule', 'Female', 'Femur', 'Mice', 'Neovascularization, Physiologic', 'Pregnancy'] | 24,482,168 | [['B01.050'], ['G07.345.500.325.377.625.050.500', 'G11.427.578.050.500'], ['A02.835.232', 'A10.165.265'], ['A05.810.453.736.560.254'], ['A02.835.232.043.150'], ['B01.050.150.900.649.313.992.635.505.500'], ['G09.330.630'], ['G08.686.784.769']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Comparison of self-esteem level of adolescents with cochlear implant and normal hearing. | OBJECTIVE: The purpose of this study is to compare the levels of self-esteem of adolescents with cochlear implants (before and after cochlear implantation) and the ones who have normal hearing.METHODS: For this purpose, Rosenberg self-esteem scale is applied upon the study group which consists of 30 adolescents with co... | ['Adolescent', 'Adult', 'Child', 'Cochlear Implantation', 'Female', 'Humans', 'Male', 'Psychological Tests', 'Self Concept'] | 16,814,401 | [['M01.060.057'], ['M01.060.116'], ['M01.060.406'], ['E04.580.450.220', 'E04.650.220'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F04.711'], ['F01.752.747.792']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Current trends in the acute treatment of ischemic stroke: analysis from the Paul Coverdell National Acute Stroke Program. | BACKGROUND: The intra-arterial treatment (IAT) of acute ischemic stroke (AIS) is now evidence-based and given the highest level of recommendation among eligible patients. Using a multi-state stroke registry, we studied the trend in IAT among patients with AIS over 11 years and its impact on the utilization of intraveno... | ['Aged', 'Brain Ischemia', 'Female', 'Fibrinolytic Agents', 'Humans', 'Infusions, Intra-Arterial', 'Infusions, Intravenous', 'Injections, Intra-Arterial', 'Injections, Intravenous', 'Male', 'Middle Aged', 'Quality Improvement', 'Registries', 'Stroke', 'Thrombolytic Therapy', 'Treatment Outcome'] | 31,653,755 | [['M01.060.116.100'], ['C10.228.140.300.150', 'C14.907.253.092'], ['D27.505.519.421.750', 'D27.505.954.411.320', 'D27.505.954.502.427'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.267.510.520'], ['E02.319.267.082.500', 'E02.319.267.510.590'], ['E02.319.267.530.370'], ['E02.319.267.082.750', 'E02.319.267... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
[Hemorrhagic complications of oral anticoagulant therapy: results of a prospective multicenter study ISCOAT (Italian Study on Complications of Oral Anticoagulant Therapy)]. | BACKGROUND: To assess the incidence of bleeding complications during oral anticoagulant therapy (OAT) in a population of patients representative of daily practice in Italian anticoagulation clinics.DESIGN: prospective, inception-cohort, multicentre.SETTING: Thirty-four anticoagulation clinics federated in the Italian F... | ['Aged', 'Anticoagulants', 'Female', 'Hemorrhage', 'Humans', 'Italy', 'Male', 'Middle Aged', 'Prospective Studies', 'Risk Factors', 'Warfarin'] | 9,244,725 | [['M01.060.116.100'], ['D27.505.954.502.119'], ['C23.550.414'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.542.489'], ['M01.060.116.630'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['E05.318.740.600.800.725', 'N05.715.350.200.700', 'N05.715.360.750.625.700.70... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Assessment of the diagnostic value of specific anti-Toxocara IgA in Slovakian patients suspected to have toxocarosis. | Human toxocarosis is one of the most widespread and prevalent helminthic zoonosis in many countries, including Slovakia. The aim was to evaluate the usefulness of IgA anti-Toxocara antibody detection in the serodiagnosis of toxocarosis. The levels of specific IgA antibodies were determined by excretory-secretory (ES)-e... | ['Adolescent', 'Adult', 'Age Factors', 'Aged', 'Aged, 80 and over', 'Animals', 'Antibodies, Anti-Idiotypic', 'Antibodies, Helminth', 'Child', 'Child, Preschool', 'Female', 'Humans', 'Immunoglobulin E', 'Infant', 'Male', 'Middle Aged', 'Sensitivity and Specificity', 'Serum Bactericidal Antibody Assay', 'Slovakia', 'Toxo... | 29,214,527 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['B01.050'], ['D12.776.124.486.485.114.071', 'D12.776.124.790.651.114.071', 'D12.776.377.715.548.114.071'], ['D12.776.124.486.485.114.185', 'D12.776.124.790.651.114.185', 'D12.776.377.715.548.114.185... | ['Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Faculty development in family medicine education: what is needed? | A growing number of countries are embracing graduate training in the specialty of Family Medicine as a core component of global health systems reform. One significant challenge for new programs is to adequately prepare for educational excellence and leadership. Promising residents are often encouraged to remain in thei... | ['Africa South of the Sahara', 'Education, Medical, Graduate', 'Faculty, Medical', 'Family Practice', 'Humans', 'Internship and Residency', 'Leadership', 'Program Development', 'Staff Development'] | 28,533,864 | [['Z01.058.290'], ['I02.358.337.350', 'I02.358.399.350'], ['M01.526.485.375', 'M01.526.702.250.373', 'N02.360.375'], ['H02.403.340.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I02.358.337.350.500', 'I02.358.399.350.750'], ['F01.752.609'], ['N04.452.760'], ['I02.574.700', 'N04.452.677.822']] | ['Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Named Groups [M]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Genome-wide DNA methylation profiles in urothelial carcinomas and urothelia at the precancerous stage. | To clarify genome-wide DNA methylation profiles during multistage urothelial carcinogenesis, bacterial artificial chromosome (BAC) array-based methylated CpG island amplification (BAMCA) was performed in 18 normal urothelia obtained from patients without urothelial carcinomas (UCs) (C), 17 noncancerous urothelia obtain... | ['Aged', 'Aged, 80 and over', 'Chromosomes, Artificial, Bacterial', 'CpG Islands', 'DNA Methylation', 'Female', 'Humans', 'Male', 'Middle Aged', 'Precancerous Conditions', 'Urinary Bladder Neoplasms'] | 19,775,289 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['A11.284.187.178.170', 'A11.284.187.190.170', 'A20.812.170', 'G05.360.162.178.170', 'G05.360.162.190.170', 'G05.360.337.249.170'], ['G02.111.570.080.380.160', 'G05.360.080.380.160', 'G05.360.340.024.159'], ['G02.111.035.538.161', 'G02.111.218', 'G03.059.538.161', 'G05.206... | ['Named Groups [M]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A virtual cataract surgery course for ophthalmologists-in-training. | Virtual reality (VR) surgery simulation is an emerging teaching tool to train residents in cataract surgery. The widespread adoption of virtual surgery has been limited, however, by high costs and the absence of standardized curricula and evidence demonstrating the impact of VR training on resident surgical outcomes. W... | ['Cataract Extraction', 'Computer Simulation', 'Computer-Assisted Instruction', 'Humans', 'Internship and Residency', 'Ophthalmology'] | 23,923,120 | [['E04.540.825.249'], ['L01.224.160'], ['I02.903.771.500.208'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I02.358.337.350.500', 'I02.358.399.350.750'], ['H02.403.810.468']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 |
Lack of Association between Polymorphisms of the TLR4 Gene and Infection with the Hepatitis B and C Viruses. | Toll-like receptor 4 (TLR4) plays a crucial role in the early recognition of pathogenic microorganisms and provides an ideal model to investigate the consequences of genetic variation and susceptibility to diseases. The present study investigated the occurrence of the single nucleotide polymorphisms (SNPs) rs4986790 (A... | ['Adult', 'Female', 'Genetic Predisposition to Disease', 'Hepatitis B', 'Hepatitis C', 'Humans', 'Male', 'Middle Aged', 'Polymorphism, Single Nucleotide', 'Toll-Like Receptor 4'] | 26,347,404 | [['M01.060.116'], ['C23.550.291.687.500', 'G05.380.355'], ['C01.221.250.500', 'C01.925.256.430.400', 'C01.925.440.435', 'C06.552.380.705.437'], ['C01.221.250.750', 'C01.925.440.440', 'C01.925.782.350.350', 'C06.552.380.705.440'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['G05.365.795.598'],... | ['Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Value of free/total prostate specific antigen in the early diagnosis of prostate cancer (study of 105 patients)]. | INTRODUCTION: Prostate Specific Antigen (PSA) exists in the serum in several molecular forms which can be measured by immunoradiodetectable assays: free PSA and total PSA (which represent the sum of the free PSA and complexed PSA to alpha 1 antichymotrypsin). Recently, the proportion of free to total PSA could enhance ... | ['Adenocarcinoma', 'Aged', 'Case-Control Studies', 'Diagnosis, Differential', 'Humans', 'Immunoradiometric Assay', 'Male', 'Prostate-Specific Antigen', 'Prostatic Hyperplasia', 'Prostatic Neoplasms', 'Reproducibility of Results', 'Sensitivity and Specificity'] | 9,264,766 | [['C04.557.470.200.025'], ['M01.060.116.100'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['E01.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.478.566.639.405', 'E05.601.470.639.405'], ['D08.811.277.656.300.760.442.750', 'D08.811.277.656.959.350.442.750', 'D12.776.866.... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The mRNA interferases, MazF-mt3 and MazF-mt7 from Mycobacterium tuberculosis target unique pentad sequences in single-stranded RNA. | mRNA interferases are sequence-specific endoribonucleases encoded by toxin-antitoxin (TA) systems in bacterial genomes. Previously, we demonstrated that Mycobacterium tuberculosis contains at least seven genes encoding MazF homologues (MazF-mt1 to -mt7) and determined cleavage specificities for MazF-mt1 and MazF-mt6. H... | ['Bacterial Proteins', 'Base Sequence', 'DNA, Single-Stranded', 'Endoribonucleases', 'Molecular Chaperones', 'Mycobacterium tuberculosis', 'RNA Stability', 'RNA, Bacterial', 'RNA, Messenger', 'Substrate Specificity'] | 18,485,066 | [['D12.776.097'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D13.444.308.497', 'G02.111.570.820.486.437', 'G05.360.580.437'], ['D08.811.277.352.355.350', 'D08.811.277.352.700.350'], ['D12.776.580'], ['B03.510.024.962.500.702', 'B03.510.460.400.410.552.552.702'], ['G02.111.780'], ['D13.444.735.473'], [... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Does quality of child care affect child outcomes at age 4(1/2)? | Research reveals associations between child-care quality and child outcomes. But are these associations causal? Data from the National Institute of Child Health and Human Development (NICHD) Study of Early Child Care. a longitudinal study of children from birth to age 4(1/2), were used to explore 5 propositions that wo... | ['Caregivers', 'Child Behavior Disorders', 'Child Care', 'Child Day Care Centers', 'Child Development', 'Child, Preschool', 'Environment Design', 'Ethnic Groups', 'Female', 'Follow-Up Studies', 'Humans', 'Infant', 'Infant, Newborn', 'Longitudinal Studies', 'Male', 'Outcome Assessment, Health Care', 'Parenting', 'Social... | 12,760,515 | [['M01.085', 'M01.526.485.200', 'N02.360.200'], ['F03.625.141'], ['I01.880.787.293.360', 'N02.421.088'], ['J03.160', 'N02.421.143.098'], ['F01.525.200', 'G07.345.374.750'], ['M01.060.406.448'], ['I01.283', 'I01.880.709.359', 'N06.230.145'], ['M01.686.754', 'N01.224.317'], ['E05.318.372.500.750.249', 'N05.715.360.330.50... | ['Named Groups [M]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Disciplines and O... | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 |
Triadin and CLIMP-63 form a link between triads and microtubules in muscle cells. | In skeletal muscle, the triad is a structure comprising a transverse (T)-tubule and sarcoplasmic reticulum (SR) cisternae. Triads constitute the basis of excitation-contraction coupling as the cradle of the Ca2+ release complex. We have shown previously that triadin, a member of this complex, has shaping properties on ... | ['Animals', 'COS Cells', 'Carrier Proteins', 'Chlorocebus aethiops', 'HEK293 Cells', 'Humans', 'Membrane Proteins', 'Mice, Knockout', 'Microtubules', 'Muscle Cells', 'Muscle Proteins', 'Phenotype', 'Protein Binding', 'Protein Domains', 'Protein Isoforms', 'Rats', 'Transfection'] | 27,562,070 | [['B01.050'], ['A11.251.210.172.500', 'A11.329.228.220'], ['D12.776.157'], ['B01.050.150.900.649.313.988.400.112.199.120.126.110'], ['A11.251.210.172.750', 'A11.436.334'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.543'], ['B01.050.050.136.500.500', 'B01.050.150.900.649.313.992.635.505.500.550.455', 'B0... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The failure of prolactin to initiate lactogenesis in the ewe. | Infusion of exogenous prolactin (NIH-P-S11) at 1 mg/h for 10 h into ewes pretreated for 30 days with oestradiol benzoate and progesterone was unable to initiate milk secretion. Similarly primed ewes injected with 10 microgram thyrotrophin releasing hormone also failed to lactate but all ewes injected with dexamethasone... | ['Animals', 'Dexamethasone', 'Estrogens', 'Female', 'Lactation', 'Pregnancy', 'Progesterone', 'Prolactin', 'Sheep', 'Thyrotropin-Releasing Hormone'] | 116,641 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Induction of mitochondrial heat shock protein 60 and 10 mRNAs following transient focal cerebral ischemia in the rat. | Heat shock proteins (HSPs) 60 and 10 are stress-inducible mitochondrial matrix proteins that form a chaperonin complex that is important for mitochondrial protein folding and function. The effect of cerebral ischemia on mitochondrial HSPs is unclear. The topographical and chronological patterns of HSP60 and HSP10 messe... | ['Animals', 'Blotting, Northern', 'Cerebral Cortex', 'Chaperonin 10', 'Chaperonin 60', 'Gene Expression Regulation', 'Hippocampus', 'In Situ Hybridization', 'Infarction, Middle Cerebral Artery', 'Ischemic Attack, Transient', 'Male', 'RNA, Messenger', 'Rats', 'Rats, Sprague-Dawley', 'Reverse Transcriptase Polymerase Cha... | 11,295,228 | [['B01.050'], ['E05.196.401.095', 'E05.301.300.074', 'E05.601.100'], ['A08.186.211.200.885.287.500'], ['D12.776.580.216.210.590.500'], ['D08.811.277.040.025.142.500.500', 'D12.776.580.216.210.590.750'], ['G05.308'], ['A08.186.211.180.405', 'A08.186.211.200.885.287.500.345'], ['E01.370.225.500.620.670.325', 'E01.370.225... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Relationship of obesity with respiratory symptoms and decreased functional capacity in adults without established COPD. | BACKGROUND: Obesity contributes to respiratory symptoms and exercise limitation, but the relationships between obesity, airflow obstruction (AO), respiratory symptoms and functional limitation are complex.AIMS: To determine the relationship of obesity with airflow obstruction (AO) and respiratory symptoms in adults wit... | ['Activities of Daily Living', 'Body Mass Index', 'Female', 'Humans', 'Interviews as Topic', 'Lung Diseases, Obstructive', 'Male', 'Middle Aged', 'Multivariate Analysis', 'Obesity', 'Odds Ratio', 'Physical Fitness', 'Prospective Studies', 'Regression Analysis', 'Smoking', 'Spirometry'] | 22,453,663 | [['E02.760.169.063.500.067', 'E02.831.067', 'I03.050', 'N02.421.784.110'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.420', 'L01.399.250.520', 'N05.715.360.300.400', 'N06.850.520.308.420'], ['C08.381.495'],... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Information Science [L]', 'Diseases [C]', 'Named Groups [M]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 0 |
Effects of chlorthalidone on serum and total body potassium in hypertensive patients. | Total body potassium has been estimated in 26 hypertensive patients who were hypokalaemic as a result of long-term chlorthalidone treatment (mean 20.5 months), while they were on chlorthalidone and 4 weeks after this had been discontinued. The mean difference amounted to only 95 mEq (not significant). In 6 additional p... | ['Adult', 'Antihypertensive Agents', 'Body Weight', 'Chlorthalidone', 'Drug Therapy, Combination', 'Electrolytes', 'Female', 'Humans', 'Hydrogen-Ion Concentration', 'Hypertension', 'Hypokalemia', 'Male', 'Middle Aged', 'Potassium', 'Potassium Chloride', 'Time Factors'] | 8,958 | [['M01.060.116'], ['D27.505.954.411.162'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['D02.065.884.365', 'D02.455.426.559.389.134.500', 'D02.478.600.500', 'D02.522.223.500', 'D02.886.590.700.365', 'D03.633.100.513.750.500'], ['E02.319.310'], ['D... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The feedback loop between miR-124 and TGF-â pathway plays a significant role in non-small cell lung cancer metastasis. | Increasing evidence shows that micro RNAs (miRNAs) play a critical role in tumor development. However, the role of miRNAs in non-small cell lung cancer (NSCLC) metastasis remains largely unknown. Here, we found that miR-124 expression was significantly impaired in NSCLC tissues and associated with its metastasis. In vi... | ['Animals', 'Blotting, Western', 'Carcinoma, Non-Small-Cell Lung', 'Cell Movement', 'Chromatin Immunoprecipitation', 'Feedback, Physiological', 'Heterografts', 'Humans', 'Immunohistochemistry', 'Lung Neoplasms', 'Mice', 'Mice, Inbred BALB C', 'MicroRNAs', 'Neoplasm Invasiveness', 'Real-Time Polymerase Chain Reaction', ... | 26,818,357 | [['B01.050'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['C04.588.894.797.520.109.220.249', 'C08.381.540.140.500', 'C08.785.520.100.220.500'], ['G04.198', 'G07.568.500.180'], ['E05.393.170', 'E05.478.605.160'], ['G07.410.732'], ['A01.941.875'], ['B01.050.150.90... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Regulation of production of delta-aminolaevulinate synthase in tissues of chick embryos. Effects of porphyrogenic agents and of haem precursors. | Studies conducted by several groups have established that porphyrogenic agents which caused elevations in chick-embryo liver delta-aminolaevulinate (ALA) synthase activity also increased the concentrations of the enzyme's RNA, and that haemin inhibited these elevations. We have determined in this study, using immune-bl... | ['5-Aminolevulinate Synthetase', 'Acetamides', 'Allylisopropylacetamide', 'Aminolevulinic Acid', 'Animals', 'Blotting, Northern', 'Chick Embryo', 'Dihydropyridines', 'Ferrous Compounds', 'Isoenzymes', 'RNA, Messenger', 'Testosterone', 'Tissue Distribution'] | 2,590,168 | [['D08.811.913.050.276'], ['D02.065.064', 'D02.241.081.018.110'], ['D02.065.064.189', 'D02.241.081.018.110.189', 'D02.455.326.271.122.272'], ['D02.241.755.547.276', 'D12.125.262'], ['B01.050'], ['E05.196.401.095', 'E05.301.300.074', 'E05.601.100'], ['A13.350.150', 'A16.331.200'], ['D03.383.725.203'], ['D01.490.200'], [... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Evaluating the biological risk of functionalized multiwalled carbon nanotubes and functionalized oxygen-doped multiwalled carbon nanotubes as possible toxic, carcinogenic, and embryotoxic agents. | Carbon nanotubes (CNTs) have been a focus of attention due to their possible applications in medicine, by serving as scaffolds for cell growth and proliferation and improving mesenchymal cell transplantation and engraftment. The emphasis on the benefits of CNTs has been offset by the ample debate on the safety of nanot... | ['Animals', 'Carcinogens', 'Cell Cycle', 'Cell Proliferation', 'Cell Transformation, Neoplastic', 'Cells, Cultured', 'Chick Embryo', 'Mesenchymal Stem Cells', 'Mice, Nude', 'Nanotubes, Carbon', 'Oxygen', 'Rats', 'Toxicity Tests'] | 29,089,764 | [['B01.050'], ['D27.888.569.100'], ['G04.144'], ['G04.161.750', 'G07.345.249.410.750'], ['C04.697.098.500', 'C23.550.727.098.500'], ['A11.251'], ['A13.350.150', 'A16.331.200'], ['A11.329.830.500', 'A11.872.590.500'], ['B01.050.150.900.649.313.992.635.505.500.550.500'], ['D01.268.150.250.500', 'J01.637.512.850.500'], ['... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Correcting mistakes in predicting distributions. | Motivation: Many applications monitor predictions of a whole range of features for biological datasets, e.g. the fraction of secreted human proteins in the human proteome. Results and error estimates are typically derived from publications.Results: Here, we present a simple, alternative approximation that uses performa... | ['Humans', 'Proteome', 'Software'] | 29,762,646 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.817'], ['L01.224.900']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Information Science [L]'] | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Characterization of the repetitive DNA elements in the genome of fish lymphocystis disease viruses. | The complete DNA nucleotide sequence of the repetitive DNA elements in the genome of fish lymphocystis disease virus (FLDV) isolated from two different species (flounder and dab) was determined. The size of these repetitive DNA elements was found to be 1413 bp which corresponds to the DNA sequences of the 5' terminus o... | ['Amino Acid Sequence', 'Animals', 'Base Sequence', 'DNA, Viral', 'Fish Diseases', 'Fishes', 'Genes', 'Genes, Viral', 'Iridoviridae', 'Molecular Sequence Data', 'Repetitive Sequences, Nucleic Acid', 'Restriction Mapping', 'Sequence Homology, Nucleic Acid', 'Viral Proteins'] | 2,773,322 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D13.444.308.568'], ['C22.362'], ['B01.050.150.900.493'], ['G05.360.340.024.340'], ['G05.360.340.024.340.364.875', 'G05.360.340.358.024.875', 'G05.360.340.358.840.500'], ['B04.280.410'], ['L01.453.245.6... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Radiation exposure--do urologists take it seriously in Turkey? | PURPOSE: A questionnaire was administered to urologists to evaluate attitudes and behaviors about protection from radiation exposure during fluoroscopy guided endourological procedures.MATERIALS AND METHODS: The questionnaire was e-mailed to 1,482 urologists, including urology residents, specialists and urologists hold... | ['Adult', 'Fluoroscopy', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Occupational Exposure', 'Radiation Protection', 'Surveys and Questionnaires', 'Turkey', 'Urology'] | 22,341,291 | [['M01.060.116'], ['E01.370.350.700.225'], ['F01.100.150.500', 'N05.300.150.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N06.850.460.350.600'], ['N06.850.810.425'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980'], ['Z01.252.245.500.850'], ['H02.403.810.860']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
Mutations in valosin-containing protein (VCP) decrease ADP/ATP translocation across the mitochondrial membrane and impair energy metabolism in human neurons. | Mutations in the gene encoding valosin-containing protein (VCP) lead to multisystem proteinopathies including frontotemporal dementia. We have previously shown that patient-derived VCP mutant fibroblasts exhibit lower mitochondrial membrane potential, uncoupled respiration, and reduced ATP levels. This study addresses ... | ['Adenosine Diphosphate', 'Adenosine Triphosphatases', 'Adenosine Triphosphate', 'Biological Transport, Active', 'Cell Cycle Proteins', 'Cell Line, Tumor', 'Humans', 'Induced Pluripotent Stem Cells', 'Mitochondrial ADP, ATP Translocases', 'Mitochondrial Membranes', 'Mutation', 'Neurodegenerative Diseases', 'Neurons', '... | 28,360,103 | [['D03.633.100.759.646.138.124', 'D13.695.667.138.124', 'D13.695.827.068.124'], ['D08.811.277.040.025'], ['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['G03.143.310'], ['D12.776.167'], ['A11.251.210.190', 'A11.251.860.180'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.872.040... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Reliable and early diagnosis of bacterial blight in pomegranate caused by Xanthomonas axonopodis pv. punicae using sensitive PCR techniques. | Bacterial blight caused by Xanthomonas axonopodis pv. punicae is a major disease of pomegranate. Bacterial blight drastically reduces the yield and quality of fruits, which are critical for pomegranate production. Precise and early diagnosis of bacterial blight is crucial for active surveillance and effective managemen... | ['DNA, Bacterial', 'Fruit', 'High-Throughput Screening Assays', 'Plant Diseases', 'Pomegranate', 'Real-Time Polymerase Chain Reaction', 'Xanthomonas axonopodis'] | 31,300,709 | [['D13.444.308.212'], ['A18.024.500', 'G07.203.300.562', 'J02.500.562'], ['E05.916.680'], ['G15.610'], ['B01.650.940.800.575.912.250.859.833.500.625'], ['E05.393.620.500.706'], ['B03.660.250.915.930.049']] | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Detecting awareness in the vegetative state. | We used functional magnetic resonance imaging to demonstrate preserved conscious awareness in a patient fulfilling the criteria for a diagnosis of vegetative state. When asked to imagine playing tennis or moving around her home, the patient activated predicted cortical areas in a manner indistinguishable from that of h... | ['Adult', 'Awareness', 'Brain', 'Brain Injuries', 'Brain Mapping', 'Consciousness', 'Female', 'Humans', 'Magnetic Resonance Imaging', 'Neurons', 'Persistent Vegetative State'] | 16,959,998 | [['M01.060.116'], ['F02.463.188.150'], ['A08.186.211'], ['C10.228.140.199', 'C10.900.300.087', 'C26.915.300.200'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['F02.463.188.409', 'F02.830.233'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['A08.675', 'A11.671... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Met-Gly-Cys motif from G-protein alpha subunit cannot direct palmitoylation when fused to heterologous protein. | To determine whether the N-terminal Met-Gly-Cys motif from G-protein alpha subunit can direct palmitoylation of protein, we have generated heterologous fusion proteins containing the first 10 amino acids of Gi1 alpha and Gs alpha using tumor necrosis factor as a model protein and determined their ability to incorporate... | ['Amino Acid Sequence', 'Animals', 'Base Sequence', 'Cell Line', 'Cysteine', 'GTP-Binding Protein alpha Subunits, Gs', 'Glycine', 'Macromolecular Substances', 'Methionine', 'Myristic Acid', 'Palmitic Acid', 'Protein Biosynthesis', 'Protein Processing, Post-Translational', 'Recombinant Fusion Proteins', 'Spodoptera', 'T... | 9,448,708 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A11.251.210'], ['D02.886.030.230', 'D02.886.489.155', 'D12.125.154.299', 'D12.125.166.230'], ['D08.811.277.040.330.300.200.100.400', 'D12.644.360.360.100.400', 'D12.776.157.325.332.100.400', 'D12.776.4... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Evidence for the long-term maintenance of a rare self-incompatibility system in Oleaceae. | A rare homomorphic diallelic self-incompatibility (DSI) system discovered in Phillyrea angustifolia (family Oleaceae, subtribe Oleinae) can promote the transition from hermaphroditism to androdioecy. If widespread and stable in Oleaceae, DSI may explain the exceptionally high rate of androdioecious species reported in ... | ['Biological Evolution', 'Flowers', 'Fraxinus', 'Oleaceae', 'Reproduction', 'Self-Incompatibility in Flowering Plants'] | 26,833,140 | [['G05.045', 'G16.075'], ['A18.024.249.500'], ['B01.650.940.800.575.912.250.583.640.374'], ['B01.650.940.800.575.912.250.583.640'], ['G08.686.784'], ['G15.840']] | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Prevalence of antibodies against Neospora caninum and Toxoplasma gondii in dogs and foxes in Austria. | Sera from 1770 dogs and 94 red foxes from Austria were examined for antibodies against Neospora caninum using the indirect immunofluorescent antibody test (IFAT). 3.6% of the dogs were seropositive with titres ranging from 1:50 to 1:6400. Dogs from rural areas were significantly more often seropositive for N. caninum t... | ['Age Factors', 'Animals', 'Antibodies, Protozoan', 'Austria', 'Coccidiosis', 'Dog Diseases', 'Dogs', 'Female', 'Fluorescent Antibody Technique, Indirect', 'Foxes', 'Male', 'Neospora', 'Rural Population', 'Seroepidemiologic Studies', 'Toxoplasma', 'Toxoplasmosis, Animal', 'Urban Population'] | 15,740,855 | [['N05.715.350.075', 'N06.850.490.250'], ['B01.050'], ['D12.776.124.486.485.114.252', 'D12.776.124.790.651.114.252', 'D12.776.377.715.548.114.252'], ['Z01.542.088'], ['C01.610.752.250'], ['C22.268'], ['B01.050.150.900.649.313.750.250.216.200'], ['E01.370.225.500.607.512.240.310', 'E01.370.225.750.551.512.240.310', 'E05... | ['Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Angiotensin converting enzyme inhibitors and Alzheimer disease in the presence of the apolipoprotein E4 allele. | OBJECTIVE: The effect of angiotensin converting enzyme (ACE) inhibitors on Alzheimer disease (AD) remains unclear, with conflicting results reported. We studied the interaction of the Apolipoprotein E (ApoE) genotype and ACE inhibitors on AD.METHODS: This was a cross-sectional study of homebound elderly with an AD diag... | ['Aged', 'Alleles', 'Alzheimer Disease', 'Angiotensin-Converting Enzyme Inhibitors', 'Apolipoprotein E4', 'Cross-Sectional Studies', 'Female', 'Humans', 'Male', 'Neuropsychological Tests', 'Peptidyl-Dipeptidase A'] | 23,567,418 | [['M01.060.116.100'], ['G05.360.340.024.340.030'], ['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['D27.505.519.389.745.085'], ['D10.532.091.500.750', 'D12.776.070.400.500.750', 'D12.776.521.120.500.750'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.6... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
What drives sleep-dependent memory consolidation: greater gain or less loss? | When memory is tested after a delay, performance is typically better if the retention interval includes sleep. However, it is unclear what accounts for this well-established effect. It is possible that sleep enhances the retrieval of information, but it is also possible that sleep protects against memory loss that norm... | ['Adolescent', 'Adult', 'Association Learning', 'Female', 'Humans', 'Male', 'Memory', 'Retention, Psychology', 'Sleep', 'Young Adult'] | 23,263,887 | [['M01.060.057'], ['M01.060.116'], ['F02.463.425.069.296'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.425.540'], ['F02.463.425.540.772'], ['F02.830.855', 'G11.561.803'], ['M01.060.116.815']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Clinical and morphological characteristics and factors of prognosis of pulmonary thromboembolism]. | Analysis of 146,521 autopsy protocols in Moscow in 2001-2005 showed that the incidence pulmonary thromboembolism (PTE) as a direct cause of death was 3.8-7%. PTE was not diagnosed during life in 20-28% of the patients who had died at hospitals and in 68-72% of those who had died at home. PTE was 2-3 times more common i... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Female', 'Humans', 'Male', 'Middle Aged', 'Prognosis', 'Pulmonary Embolism', 'Retrospective Studies', 'Sex Factors', 'Venous Thrombosis'] | 19,385,132 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.789'], ['C08.381.746', 'C14.907.355.350.700'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825',... | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Clinical course and surgical treatment of macular epiretinal membranes in young subjects. | OBJECTIVE: To examine the surgical and nonsurgical visual outcomes of young subjects with idiopathic macular epiretinal membranes (ERMs).DESIGN: Retrospective observational and noncomparative interventional case series.PARTICIPANTS: Nineteen consecutive subjects (20 eyes) aged 40 years or less with an idiopathic macula... | ['Adolescent', 'Adult', 'Child', 'Epiretinal Membrane', 'Female', 'Fundus Oculi', 'Humans', 'Macula Lutea', 'Male', 'Recurrence', 'Retrospective Studies', 'Treatment Outcome', 'Visual Acuity', 'Vitrectomy'] | 11,150,258 | [['M01.060.057'], ['M01.060.116'], ['M01.060.406'], ['C11.768.328'], ['A09.371.729.313'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A09.371.729.522'], ['C23.550.291.937'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.520.450.500.5... | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Total metabolic tumor volume, circulating tumor cells, cell-free DNA: distinct prognostic value in follicular lymphoma. | Outcomes for follicular lymphoma (FL) have greatly improved, but most patients will ultimately relapse. High total metabolic tumor volume (TMTV), computed from baseline 18F-fluorodeoxyglucose-positron emission tomography (PET), is associated with shorter progression-free survival (PFS), but circulating tumor cells (CTC... | ['Adult', 'Aged', 'Circulating Tumor DNA', 'Female', 'Humans', 'Lymphoma, Follicular', 'Male', 'Middle Aged', 'Neoplastic Cells, Circulating', 'Polymerase Chain Reaction', 'Predictive Value of Tests', 'Prognosis', 'Retrospective Studies', 'Survival Analysis', 'Tumor Burden'] | 29,636,326 | [['M01.060.116'], ['M01.060.116.100'], ['D13.444.154.500', 'D13.444.308.425.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.386.480.350', 'C15.604.515.569.480.350', 'C20.683.515.761.480.350'], ['M01.060.116.630'], ['A11.642', 'C04.697.650.900', 'C23.550.727.650.900'], ['E05.393.620.500'], ['E05.318.37... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Transformation of expression intensities across generations of Affymetrix microarrays using sequence matching and regression modeling. | The utility of previously generated microarray data is severely limited owing to small study size, leading to under-powered analysis, and failure of replication. Multiplicity of platforms and various sources of systematic noise limit the ability to compile existing data from similar studies. We present a model for tran... | ['Algorithms', 'Cluster Analysis', 'Gene Expression Profiling', 'Humans', 'Linear Models', 'Oligonucleotide Array Sequence Analysis', 'Oligonucleotide Probes', 'Sequence Analysis'] | 16,224,098 | [['G17.035', 'L01.224.050'], ['E05.318.740.250', 'N05.715.360.750.200', 'N06.850.520.830.250'], ['E05.393.332'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.500', 'E05.318.740.750.425', 'E05.599.835.750', 'N05.715.360.750.530.460', 'N05.715.360.750.695.460', 'N06.850.520.830.500.500', 'N06.850.52... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
A slice geometry phantom for cross sectional tomographic imagers. | This investigation presents the design and fabrication of a magnetic resonance imaging (MRI) test phantom for determining slice thickness, slice adjacency, slice offset, and slice angulation. This test phantom is a three-dimensional conic section of MRI image producing material; proper orientation allows analysis in ea... | ['Humans', 'Magnetic Resonance Imaging', 'Models, Structural', 'Quality Assurance, Health Care', 'Tomography, Emission-Computed', 'Tomography, X-Ray Computed'] | 2,785,637 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['J01.897.280.500.545', 'L01.178.820.090.545'], ['N04.761.700', 'N05.700'], ['E01.370.350.350.800', 'E01.370.350.600.350.800', 'E01.370.350.710.800', 'E01.370.350.825.800', 'E01.370.384.730.800'], ['E01.370.350.350.810', 'E01.370.350.600.350.700... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 |
Expression of human papillomavirus proteins in yeast Saccharomyces cerevisiae. | The L1 and L2 proteins of human papillomavirus (HPV) types 1, 6, and 16 and the E6 and E7 proteins of HPV 16 were expressed in Saccharomyces cerevisiae. The yeast expressed proteins were readily detected by immune blotting and were generally intact. The HPV 1 L1 and L2 proteins expressed in yeast were indistinguishable... | ['Antibodies, Viral', 'Antigens, Viral', 'Cloning, Molecular', 'Gene Expression', 'Glycoproteins', 'Glycosylation', 'Humans', 'In Vitro Techniques', 'Molecular Weight', 'Papillomaviridae', 'Polymerase Chain Reaction', 'Precipitin Tests', 'Protein Processing, Post-Translational', 'Recombinant Proteins', 'Saccharomyces c... | 1,850,917 | [['D12.776.124.486.485.114.254', 'D12.776.124.790.651.114.254', 'D12.776.377.715.548.114.254'], ['D23.050.327'], ['E05.393.220'], ['G05.297'], ['D09.400.430', 'D12.776.395'], ['G02.111.158.812', 'G02.607.299', 'G03.191.812'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.481'], ['G02.494'], ['B04.280.210.655',... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Generation of phosphorescent triplet states via photoinduced electron transfer: energy and electron transfer dynamics in Pt porphyrin-Rhodamine B dyads. | Control over generation and dynamics of excited electronic states is fundamental to their utilization in all areas of technology. We present the first example of multichromophoric systems in which emissive triplet states are generated via a pathway involving photoinduced electron transfer (ET), as opposed to local intr... | ['Electron Transport', 'Electrons', 'Energy Transfer', 'Light', 'Luminescent Measurements', 'Molecular Structure', 'Oxygen', 'Photochemical Processes', 'Piperazines', 'Platinum', 'Porphyrins', 'Rhodamines', 'Spectrum Analysis', 'Temperature', 'Thermodynamics'] | 22,400,988 | [['G02.111.248', 'G03.295.531.403', 'G03.493.350'], ['G01.249.335', 'G01.358.500.750'], ['G01.154.240', 'G02.111.255', 'G02.216'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['E05.196.712.516'], ['G02.111.570', 'G02.466'], ['D01.268.185.550', 'D01.362.670'], ['G02.740'], ['D03.383.606... | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Dexamethasone inhibits IL-1 beta gene expression in LPS-stimulated RAW 264.7 cells by blocking NF-kappa B/Rel and AP-1 activation. | In the present study, the mechanism by which dexamethasone (DEX) inhibited IL-1beta gene expression in bacterial lipopolysaccharide (LPS)-activated RAW 264.7 cells was investigated. The decrease in LPS-induced IL-1beta mRNA expression was demonstrated by quantitative reverse transcription polymerase chain reaction (RT-... | ['Animals', 'Cell Line', 'Cell Nucleus', 'Dexamethasone', 'Enhancer Elements, Genetic', 'Gene Expression Regulation', 'Interleukin-1', 'Lipopolysaccharides', 'Macrophage Activation', 'Macrophages', 'Mice', 'NF-kappa B', 'Protein Binding', 'Proto-Oncogene Proteins c-rel', 'Transcription Factor AP-1'] | 10,936,515 | [['B01.050'], ['A11.251.210'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['D04.210.500.745.432.769.344', 'D04.210.500.908.238'], ['G02.111.570.080.689.330', 'G05.360.080.689.330', 'G05.360.340.024.340.137.750.249'], ['G05.308'], ['D12.644.276.374.465.010', 'D12.644.276.374.500.400', 'D12.776.467.374.465.010',... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Energy Expenditure in Older People Hospitalized for an Acute Episode. | Weight loss and worsening of nutritional state is a frequent downfall of acute hospitalization in older people. It is usually accepted that acute inflammation is responsible for hypercatabolism. However, several studies suggest, on the contrary, a reduction in resting energy expenditure (REE). This study aimed to obtai... | ['Acute Disease', 'Aged', 'Aged, 80 and over', 'Body Composition', 'Calorimetry, Indirect', 'Energy Intake', 'Energy Metabolism', 'Female', 'Frail Elderly', 'Hospitalization', 'Humans', 'Male', 'Nutritional Requirements', 'Nutritional Status', 'Weight Loss'] | 31,817,061 | [['C23.550.291.125'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['G02.111.130', 'G03.180', 'G07.100.049'], ['E05.196.131.655'], ['G07.203.650.240.340'], ['G03.295'], ['M01.060.116.100.540'], ['E02.760.400', 'N02.421.585.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G07.203.650.620'], ['G07.203.650.650',... | ['Diseases [C]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Inhibition of factor XIII activation by an anti-peptide monoclonal antibody. | As the final enzyme in the coagulation cascade, activated fibrin stabilizing factor or factor XIII catalyzes the intermolecular cross-linking of fibrin chains. To study this enzyme in plasma, we derived a monoclonal antibody (MAb 309) against a peptide sequence (NH2-G-V-N-L-Q-E-F-C-COOH) in the thrombin activation site... | ['Amino Acid Sequence', 'Animals', 'Antibodies, Monoclonal', 'Binding Sites, Antibody', 'Binding, Competitive', 'Enzyme Activation', 'Factor XIII', 'Humans', 'Mice', 'Mice, Inbred BALB C', 'Molecular Sequence Data', 'Peptides', 'Thrombin', 'Transglutaminases'] | 1,681,898 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['G02.111.570.060.425.079', 'G02.111.570.120.408', 'G12.122.232', 'G12.125'], ['E05.196.080', 'G02.111.084', 'G02.111.570.120.309'], ['G02.111.263', 'G03.328'], ['D08.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
[Dysphagia - epidemiology, diagnostics, therapy and nutrition-management]. | BACKGROUND: Swallowing is a complex neuro-muscular process at which around 50 muscle couples need to be coordinated. The swallowing process is controlled by the swallowing centres in cortex and brainstem as well as by five brain nerves.EPIDEMIOLOGY: Severe dysphagia appears most frequently in the context of neurologica... | ['Cross-Sectional Studies', 'Deglutition Disorders', 'Dehydration', 'Enteral Nutrition', 'Humans', 'Laryngoscopy', 'Mass Screening', 'Patient Care Team', 'Pneumonia, Aspiration', 'Protein-Energy Malnutrition', 'Stroke', 'Video Recording'] | 19,347,785 | [['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['C06.405.117.119', 'C09.775.174'], ['C18.452.950.179', 'C23.550.274'], ['E02.421.360', 'E02.642.500.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.386.460', 'E01.370.388.250.525', 'E04.502.250.525', 'E04.580.373'], ['E01... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Information Science [L]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Radiation Dosimetry of Whole-Body Dual-Tracer 18F-FDG and 11C-Acetate PET/CT for Hepatocellular Carcinoma. | UNLABELLED: Combined whole-body dual-tracer ((18)F-FDG and (11)C-acetate) PET/CT is increasingly used for staging hepatocellular carcinoma, with only limited studies investigating the radiation dosimetry data of these scans. The aim of the study was to characterize the radiation dosimetry of combined whole-body dual-tr... | ['Acetates', 'Aged', 'Aged, 80 and over', 'Carbon Radioisotopes', 'Carcinoma, Hepatocellular', 'Female', 'Fluorodeoxyglucose F18', 'Humans', 'Liver Neoplasms', 'Male', 'Middle Aged', 'Positron Emission Tomography Computed Tomography', 'Radioactive Tracers', 'Radiometry', 'Retrospective Studies', 'Risk', 'Whole Body Ima... | 26,823,568 | [['D02.241.081.018', 'D10.251.400.045'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D01.268.150.075.328', 'D01.496.123.328', 'D01.496.749.154'], ['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['D09.254.229.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Motor and cognitive aspects of motor retardation in depression. | BACKGROUND: Motor retardation is a common feature of major depressive disorder having potential prognostic and etiopathological significance. According to DSM-IV, depressed patients who meet criteria for psychomotor retardation, must exhibit motor slowing of sufficient severity to be observed by others. However, overt ... | ['Antidepressive Agents', 'Antipsychotic Agents', 'Basal Ganglia', 'Bipolar Disorder', 'Cognition Disorders', 'Cognitive Behavioral Therapy', 'Depressive Disorder, Major', 'Female', 'Humans', 'Male', 'Middle Aged', 'Psychiatric Status Rating Scales', 'Psychomotor Disorders', 'Reaction Time', 'Severity of Illness Index'... | 10,708,819 | [['D27.505.954.427.700.122'], ['D27.505.696.277.950.040', 'D27.505.954.427.210.950.040', 'D27.505.954.427.700.872.331'], ['A08.186.211.200.885.287.249'], ['F03.084.500'], ['F03.615.250'], ['F04.754.137.350'], ['F03.600.300.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['F04.711.513.653'],... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Distribution of genetic markers of fecal pollution on a freshwater sandy shoreline in proximity to wastewater effluent. | Water, sand, and sediment from a Lake Superior harbor site continuously receiving wastewater effluent was sampled monthly for June to October 2010 and from May to September 2011. Understanding the dynamics of genetic markers of fecal bacteria in these matrices is essential to accurately characterizing health risks. Gen... | ['Bacteria', 'Bacteroides', 'Colony Count, Microbial', 'Enterococcus', 'Environmental Monitoring', 'Feces', 'Fresh Water', 'Genetic Markers', 'Geography', 'Geologic Sediments', 'Humans', 'Minnesota', 'Sewage', 'Silicon Dioxide', 'Waste Disposal, Fluid', 'Waste Water', 'Water Pollution'] | 23,473,470 | [['B03'], ['B03.440.080.094.152', 'B03.440.425.410.194.152'], ['E01.370.225.875.220', 'E05.200.875.220'], ['B03.353.750.250.250', 'B03.510.550.250.250'], ['N06.850.460.350.080', 'N06.850.780.375'], ['A12.459'], ['G16.500.275.280', 'N06.230.232'], ['D23.101.387', 'G05.695.450'], ['H01.277.500'], ['G01.311.330', 'G16.500... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Geographicals [Z]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
Deletion of GOLGA2P3Y but not GOLGA2P2Y is a risk factor for oligozoospermia. | The AZFc locus on the human Y chromosome harbours several multicopy genes, some of which are required for spermatogenesis. It is believed that deletion of one or more copies of these genes is a cause of infertility in some men. GOLGA2LY is one of the genes in the AZFc locus and it exists in two copies, GOLGA2P2Y and GO... | ['Autoantigens', 'Chromosomes, Human, Y', 'Gene Deletion', 'Gene Rearrangement', 'Genetic Predisposition to Disease', 'Humans', 'Infertility, Male', 'Male', 'Membrane Proteins', 'Oligospermia', 'Risk Factors', 'Sequence Deletion', 'Sperm Count', 'Sperm Motility', 'Spermatogenesis', 'Spermatozoa', 'Temperature'] | 26,655,651 | [['D23.050.422'], ['A11.284.187.520.300.505.757', 'A11.284.187.865.983.500', 'G05.360.162.520.300.505.757', 'G05.360.162.865.983.500'], ['G05.365.590.762.320', 'G05.558.800.320'], ['G05.344'], ['C23.550.291.687.500', 'G05.380.355'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.294.365.700'], ['D12.776.543'], ... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Impact of germline and somatic missense variations on drug binding sites. | Advancements in next-generation sequencing (NGS) technologies are generating a vast amount of data. This exacerbates the current challenge of translating NGS data into actionable clinical interpretations. We have comprehensively combined germline and somatic nonsynonymous single-nucleotide variations (nsSNVs) that affe... | ['Animals', 'Binding Sites', 'Computational Biology', 'Data Mining', 'Databases, Genetic', 'Genotype', 'Germ-Line Mutation', 'High-Throughput Nucleotide Sequencing', 'Humans', 'Models, Molecular', 'Mutation, Missense', 'Pharmaceutical Preparations', 'Pharmacogenetics', 'Pharmacogenomic Variants', 'Phenotype', 'Precisio... | 26,810,135 | [['B01.050'], ['G02.111.570.120'], ['H01.158.273.180', 'L01.313.124'], ['L01.313.500.750.280.199', 'L01.470.625'], ['L01.313.500.750.300.188.400.325', 'L01.470.750.750.325'], ['G05.380'], ['G05.365.590.350'], ['E05.393.760.319'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.595'], ['G05.365.590.650'], ['D... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Toddlers' concentration: does maternal depression make a difference? | Twenty-five mother-toddler dyads with depressed mothers were compared with 25 dyads with well mothers on measures of attention during 20 min of spontaneous play in a home-like setting. Children of depressed women focused attention on more objects for shorter durations. Group differences could be accounted for by mother... | ['Adult', 'Arousal', 'Attention', 'Child, Preschool', 'Depressive Disorder', 'Female', 'Humans', 'Infant', 'Male', 'Mother-Child Relations', 'Play and Playthings', 'Risk Factors'] | 3,417,803 | [['M01.060.116'], ['F02.830.104', 'G11.561.035'], ['F02.830.104.214'], ['M01.060.406.448'], ['F03.600.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['F01.829.263.370.290.170'], ['I03.450.642.693'], ['E05.318.740.600.800.725', 'N05.715.350.200.700', 'N05.715.360.750.625.700.700', 'N06.850.490.... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Scaling up Pediatric HIV Testing by Incorporating Provider-Initiated HIV Testing Into all Child Health Services in Hurungwe District, Zimbabwe. | BACKGROUND: Practical ways are needed to scale-up pediatric HIV testing in sub-Saharan Africa, where testing is usually limited to HIV-exposed children in maternal and child health clinics.METHODS: We implemented an enhanced pediatric HIV testing program in 33 health facilities in Zimbabwe by integrating HIV testing in... | ['Child Health Services', 'Child, Preschool', 'Delivery of Health Care, Integrated', 'Female', 'HIV Infections', 'Health Facilities', 'Health Personnel', 'Health Plan Implementation', 'Humans', 'Infant', 'Infant, Newborn', 'Male', 'Mass Screening', 'Zimbabwe'] | 28,991,881 | [['N02.421.143.130'], ['M01.060.406.448'], ['N04.590.374.142', 'N05.300.262'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['N02.278'], ['M01.526.485', 'N02.360'], ['N03.349.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.... | ['Health Care [N]', 'Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Ophthalmic manifestations in Asian patients with systemic lupus erythematosus. | AIM OF STUDY: To determine the spectrum and prevalence of ophthalmic manifestations of systemic lupus erythematosus (SLE) in Asian patients.METHODS: We performed a standardised ophthalmic examination on consecutive Asian patients with SLE referred from a tertiary rheumatology unit to an ophthalmology department.RESULTS... | ['Adolescent', 'Adult', 'Aged', 'Child', 'Cross-Sectional Studies', 'Eye Diseases', 'Female', 'Humans', 'Lupus Erythematosus, Systemic', 'Male', 'Middle Aged', 'Prevalence', 'Prospective Studies', 'Vision Screening', 'Visual Acuity'] | 10,067,401 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.406'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['C11'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C17.300.480', 'C20.111.590'], ['M01.060.116.630'], ['E05.318.308.985.525.750', 'N01.224.935.597.750', 'N06.8... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[A case of renal cell carcinoma difficult to diagnose preoperatively because of hypovascular findings]. | A 35-year-old man visited our out-patient clinic with the chief complaint of macroscopic hematuria. After admission to the hospital, examinations by CT scan, renal angiography, etc. revealed a hypovascular space-occupying lesion in the right kidney, but no definite diagnosis could be made; blood findings such as accent... | ['Adult', 'Carcinoma, Renal Cell', 'Gallium Radioisotopes', 'Humans', 'Kidney Neoplasms', 'Male', 'Renal Artery', 'Tomography, X-Ray Computed'] | 3,864,364 | [['M01.060.116'], ['C04.557.470.200.025.390', 'C04.588.945.947.535.160', 'C12.758.820.750.160', 'C12.777.419.473.160', 'C13.351.937.820.535.160', 'C13.351.968.419.473.160'], ['D01.268.556.289.500.400', 'D01.496.360.400', 'D01.496.749.360', 'D01.552.544.289.500.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Differential effects of L-NAME on rat venular hydraulic conductivity. | The role of nitric oxide (NO) in microvascular permeability remains unclear because both increases and decreases in permeability by NO synthase (NOS) inhibitors have been reported. We sought to determine whether blood-borne constituents modify venular permeability responses to the NOS inhibitor N(G)-nitro-L-arginine me... | ['Animals', 'Arginine', 'Capillary Permeability', 'Enzyme Inhibitors', 'Male', 'NG-Nitroarginine Methyl Ester', 'Nitric Oxide Synthase', 'Rats', 'Rats, Sprague-Dawley', 'Splanchnic Circulation', 'Venules'] | 11,009,493 | [['B01.050'], ['D12.125.068.050', 'D12.125.095.104', 'D12.125.142.087'], ['G03.143.330', 'G09.330.165'], ['D27.505.519.389'], ['D12.125.068.050.525', 'D12.125.095.104.525'], ['D08.811.682.664.500.772'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.750'], ['G09.330.100.881'], ['... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Rearrangements of 11q in patients with hematologic malignancies]. | BACKGROUND: The aim of this study was to investigate the rearrangement of MLL gene in bone marrow cells of patients with hematological malignancies with various types of 11q aberrations. These aberrations have been observed in acute lymphoblastic and acute myeloid leukemias as well as in myelodysplasias and lymphomas.M... | ['Adult', 'Chromosomes, Human, Pair 11', 'DNA-Binding Proteins', 'Female', 'Gene Rearrangement', 'Hematologic Neoplasms', 'Histone-Lysine N-Methyltransferase', 'Humans', 'Leukemia, Myeloid', 'Male', 'Myelodysplastic Syndromes', 'Myeloid-Lymphoid Leukemia Protein', 'Precursor Cell Lymphoblastic Leukemia-Lymphoma', 'Prot... | 12,428,421 | [['M01.060.116'], ['A11.284.187.520.300.325.355', 'G05.360.162.520.300.325.355'], ['D12.776.260'], ['G05.344'], ['C04.588.448', 'C15.378.400'], ['D08.811.913.555.500.800.200.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.337.539'], ['C15.378.190.625'], ['D12.776.260.560', 'D12.776.624.664.700.148', '... | ['Named Groups [M]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Attention to action and awareness of other minds. | We have only limited awareness of the system by which we control our actions and this limited awareness does not seem to be concerned with the control of action. Awareness of choosing one action rather than another comes after the choice has been made, while awareness of initiating an action occurs before the movement ... | ['Attention', 'Awareness', 'Communication', 'Humans', 'Mind-Body Relations, Metaphysical', 'Models, Psychological', 'Perception'] | 12,470,618 | [['F02.830.104.214'], ['F02.463.188.150'], ['F01.145.209', 'L01.143'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.509'], ['E05.599.695'], ['F02.463.593']] | ['Psychiatry and Psychology [F]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Why and how do systems react in thermally fluctuating environments? | Many chemical reactions, including those of biological importance, take place in thermally fluctuating environments. Compared to isolated systems, there arise markedly different features due to the effects of energy dissipation through friction and stochastic driving by random forces reflecting the fluctuation of the e... | ['Algorithms', 'Models, Chemical', 'Temperature'] | 22,048,614 | [['G17.035', 'L01.224.050'], ['E05.599.495'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.150.450', 'N06.230.300.100.725.710']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Joint statement of the European Association for the Study of Obesity and the European Society of Hypertension: obesity and difficult to treat arterial hypertension. | Obese patients are prone to arterial hypertension, require more antihypertensive medications, and have an increased risk of treatment-resistant arterial hypertension. Obesity-induced neurohumoral activation appears to be involved. The association between obesity and hypertension shows large inter-individual variability... | ['Antihypertensive Agents', 'Bariatric Surgery', 'Blood Pressure', 'Europe', 'Humans', 'Hypertension', 'Life Style', 'Obesity', 'Practice Guidelines as Topic', 'Weight Loss'] | 22,573,071 | [['D27.505.954.411.162'], ['E02.650.500.062', 'E04.062'], ['E01.370.600.875.249', 'G09.330.380.076'], ['Z01.542'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['F01.829.458'], ['C18.654.726.500', 'C23.888.144.699.500', 'E01.370.600.115.100.160.120.699.500', 'G07.100.100.160.120.699.500'], ['N04.76... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Pharmacokinetic-pharmacodynamic profiling of four antimicrobials against gram-negative bacteria collected from Shenyang, China. | BACKGROUND: To examine common antimicrobial regimens used in eradicating certain nosocomial gram-negative pathogens and determine which ones are likely to be the most suitable as empirical choices in Shenyang, China.METHODS: A 5000-subject Monte Carlo simulation was conducted to determine the cumulative fraction of res... | ['Anti-Bacterial Agents', 'China', 'Cross Infection', 'Gram-Negative Bacteria', 'Gram-Negative Bacterial Infections', 'Humans', 'beta-Lactams'] | 20,546,625 | [['D27.505.954.122.085'], ['Z01.252.474.164'], ['C01.248', 'C23.550.291.875.500'], ['B03.440'], ['C01.150.252.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.065.589.099', 'D02.886.108', 'D03.633.100.300']] | ['Chemicals and Drugs [D]', 'Geographicals [Z]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Medicare program; swing-bed program changes--HCFA. Interim rule with comment period. | These interim rules revise the current Medicare rules relating to approved swing-bed hospitals. They expand the allowable rural hospital bed size from 49 beds to 99 beds. They require approved swing-bed hospitals with more than 49 beds t:--Transfer extended care hospital patients within 5 days to an available skilled n... | ['Bed Conversion', 'Centers for Medicare and Medicaid Services, U.S.', 'Health Facility Planning', 'Hospitals, Rural', 'Medicaid', 'Medicare', 'Skilled Nursing Facilities', 'United States'] | 10,303,830 | [['N03.349.650.250.080'], ['I01.409.418.750.600.310', 'N03.540.348.500.500.600.550'], ['N03.349.650.250'], ['N02.278.421.518'], ['N03.219.521.346.506.564.655', 'N03.706.615.693'], ['N03.219.521.346.506.564.663', 'N03.219.521.576.343.840', 'N03.706.615.696'], ['N02.278.825.610.770'], ['Z01.107.567.875']] | ['Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
High-resolution mapping of changes in histone-DNA contacts of nucleosomes remodeled by ISW2. | The imitation switch (ISWI) complex from yeast containing the Isw2 and Itc1 proteins was shown to preferentially slide mononucleosomes with as little as 23 bp of linker DNA from the end to the center of DNA. The contacts of unique residues in the histone fold regions of H4, H2B, and H2A with DNA were determined with ba... | ['Adenosine Triphosphatases', 'Base Sequence', 'Chromatin', 'DNA', 'Dose-Response Relationship, Drug', 'Escherichia coli', 'Histones', 'Models, Genetic', 'Models, Molecular', 'Molecular Sequence Data', 'Mutation', 'Nucleosomes', 'Plasmids', 'Protein Binding', 'Protein Biosynthesis', 'Protein Conformation', 'Saccharomyc... | 12,370,299 | [['D08.811.277.040.025'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A11.284.430.106.279.345.190.160.180', 'D12.776.664.224', 'G05.360.160.180'], ['D13.444.308'], ['G07.690.773.875', 'G07.690.936.500'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D12.776.157.687.485', 'D12.776.660.720.48... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Pain measurement in older adults with head and neck cancer and communication impairments. | The ability to communicate the presence of pain by means of verbal and nonverbal communication is crucial to facilitate the assessment of pain. Patients with communication impairment (CI) are limited in their ability to verbally report their pain and, consequently, mechanisms to elicit information about the pain experi... | ['Aged', 'Aged, 80 and over', 'Attitude to Health', 'Communication Disorders', 'Female', 'Geriatric Assessment', 'Head and Neck Neoplasms', 'Humans', 'Laryngectomy', 'Linear Models', 'Male', 'Middle Aged', 'Multivariate Analysis', 'Nursing Assessment', 'Nursing Evaluation Research', 'Oncology Nursing', 'Pain Measuremen... | 15,632,781 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['F01.100.150', 'N05.300.150'], ['C10.597.606.150', 'C23.888.592.604.150', 'F03.625.374'], ['E05.318.308.225', 'I01.240.425.350', 'N01.224.425.350', 'N05.715.360.300.360', 'N06.850.505.400.425.350', 'N06.850.520.308.225'], ['C04.588.443'], ['B01.050.150.900.649.313.988.400... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Geographica... | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
The recent recombinant evolution of a major crop pathogen, potato virus Y. | Potato virus Y (PVY) is a major agricultural disease that reduces crop yields worldwide. Different strains of PVY are associated with differing degrees of pathogenicity, of which the most common and economically important are known to be recombinant. We need to know the evolutionary origins of pathogens to prevent furt... | ['Crops, Agricultural', 'DNA, Viral', 'Evolution, Molecular', 'Homologous Recombination', 'Phylogeny', 'Potyvirus', 'Recombination, Genetic', 'Sequence Analysis, DNA', 'Solanum tuberosum', 'Time Factors'] | 23,226,339 | [['B01.650.160', 'G07.203.300.300', 'J02.500.300'], ['D13.444.308.568'], ['G05.045.250', 'G16.075.250'], ['G05.728.615'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['B04.715.464.600', 'B04.715.635.600', 'B04.820.578.782.600'], ['G05.728'], ['E05.393.760.700'], ['B01.650.940.800.575.912.250.908.500.725.777'], ['G01.910... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Fetomaternal outcome in severe preeclamptic women undergoing emergency cesarean section under either general or spinal anesthesia. | This prospective observational study compared the effects of general and spinal anesthesia in 173 severe preeclamptic women undergoing emergency cesarean section. 146 (84.5%) patients underwent spinal anesthesia (SA) and 27 (15.5%) patients had general anesthesia (GA). Most of the patients were primigravid and nullipar... | ['Adolescent', 'Adult', 'Anesthesia, General', 'Anesthesia, Spinal', 'Anticonvulsants', 'Antihypertensive Agents', 'Apgar Score', 'Cesarean Section', 'Female', 'Fetal Mortality', 'Gestational Age', 'Humans', 'Infant, Newborn', 'Infant, Premature', 'Labetalol', 'Magnesium Sulfate', 'Maternal Mortality', 'Methyldopa', 'P... | 24,864,211 | [['M01.060.057'], ['M01.060.116'], ['E03.155.197'], ['E03.155.086.331'], ['D27.505.954.427.080'], ['D27.505.954.411.162'], ['E01.370.600.050'], ['E04.520.252.500'], ['E05.318.308.985.550.362', 'N01.224.935.698.300', 'N06.850.505.400.975.550.362', 'N06.850.520.308.985.550.362'], ['G07.345.500.325.235.968', 'G08.686.320'... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Tumor necrosis factor alpha (rhTNF) fails to stimulate angiogenesis in the rabbit cornea. | BACKGROUND: The objective of this study was to thoroughly examine the in vivo angiogenesis activity of human recombinant tumor necrosis factor alpha (rhTNF).METHODS: rhTNF (0.5 ng to 1.0 microgram) was incorporated into the slow release polymers Hydron or HYPAN and implanted into the rabbit cornea. Release of biologica... | ['Acrylic Resins', 'Animals', 'Cornea', 'Drug Carriers', 'Female', 'Neovascularization, Physiologic', 'Prostheses and Implants', 'Rabbits', 'Recombinant Proteins', 'Statistics, Nonparametric', 'Tumor Necrosis Factor-alpha'] | 8,731,040 | [['D05.750.716.822.111', 'D25.720.716.822.111', 'J01.637.051.720.716.822.111'], ['B01.050'], ['A09.371.060.217'], ['D26.255.260', 'E02.319.300.380'], ['G09.330.630'], ['E07.695'], ['B01.050.150.900.649.313.968.700'], ['D12.776.828'], ['E05.318.740.995', 'N05.715.360.750.760', 'N06.850.520.830.995'], ['D12.644.276.374.5... | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Vasoconstrictor effect of midodrine, ST 1059, noradrenaline, etilefrine and dihydroergotamine on isolated human veins. | ST 1059, the pharmacologically active metabolite of midodrine, is a powerful vasoconstrictor compound, acting by stimulation of alpha-receptors. It elicited 80% of noradrenaline-induced contraction of human veins. | ['Dihydroergotamine', 'Ethanolamines', 'Etilefrine', 'Humans', 'In Vitro Techniques', 'Midodrine', 'Muscle, Smooth, Vascular', 'Norepinephrine', 'Phenylephrine', 'Vasoconstrictor Agents', 'Veins'] | 93,544 | [['D03.132.327.412.225', 'D03.633.400.562.300'], ['D02.033.100.291', 'D02.033.375.291', 'D02.092.063.291'], ['D02.033.100.291.617.300', 'D02.092.063.291.617.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.481'], ['D02.033.100.291.480', 'D02.092.063.291.480'], ['A02.633.570.491', 'A07.015.733.500', 'A10.69... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Splicing site mutations in dentin sialophosphoprotein causing dentinogenesis imperfecta type II. | Dentinogenesis imperfecta (DGI) type II (OMIM # 125490) is an inherited disorder affecting dentin. Defective dentin formation results in discolored teeth that are prone to attrition and fracture. To date, several mutations have been described in the dentin sialophosphoprotein (DSPP) gene, causing DGI types II and III a... | ['Child', 'DNA Mutational Analysis', 'Dentin', 'Dentinogenesis Imperfecta', 'Exons', 'Extracellular Matrix Proteins', 'Finland', 'Genetic Linkage', 'Genetic Markers', 'Humans', 'Male', 'Mutation', 'Pedigree', 'Phenotype', 'Phosphoproteins', 'Sequence Analysis, DNA', 'Sialoglycoproteins', 'Surveys and Questionnaires'] | 17,026,502 | [['M01.060.406'], ['E05.393.760.700.300'], ['A14.549.167.900.280'], ['C07.650.800.270', 'C07.793.700.270', 'C16.131.850.800.270'], ['G05.360.340.024.340.137.232'], ['D12.776.860.300'], ['Z01.542.816.186'], ['G05.348'], ['D23.101.387', 'G05.695.450'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G05.365.590'], ['E... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Otago glaucoma surgery outcome study: tissue matrix breakdown by apoptotic cells in capsules surrounding molteno implants. | PURPOSE: To identify cell types and extracellular matrix components in Molteno implant capsules.METHODS: Histologic features including cytology, distribution of apoptotic cells, cytoantigens, collagens, basement membranes, elastic fibers, and glycoproteins were examined by light microscopy. Findings were correlated wit... | ['Adult', 'Aged', 'Aged, 80 and over', 'Apoptosis', 'Basement Membrane', 'Connective Tissue', 'Extracellular Matrix Proteins', 'Eye Enucleation', 'Female', 'Fibroblasts', 'Glaucoma', 'Humans', 'Immunoenzyme Techniques', 'In Situ Nick-End Labeling', 'Macrophages', 'Male', 'Molteno Implants', 'Vacuoles'] | 18,978,350 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['G04.146.954.035'], ['A10.272.220', 'A10.615.179'], ['A10.165'], ['D12.776.860.300'], ['E04.540.429'], ['A11.329.228'], ['C11.525.381'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.478.566.350', 'E05.478.583.400', 'E05.601.470.350'], ['E05.393.... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Development of fluorescent protein-based biosensing strains: A new tool for the detection of aromatic hydrocarbon pollutants in the environment. | The major sources for release of hydrocarbons into the environment include the effluents generated from chemical processing industries and ports. The introduction of such hazardous compounds into natural water bodies creates considerable disturbances in aquatic life and causes a threat to humans. Thus, it is essential ... | ['Biosensing Techniques', 'Escherichia coli', 'Genes, Reporter', 'Green Fluorescent Proteins', 'Humans', 'Hydrocarbons, Aromatic', 'Promoter Regions, Genetic', 'Waste Water', 'Water Pollutants, Chemical', 'Water Purification'] | 31,349,104 | [['E05.601.043'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['G05.360.340.024.340.435'], ['D12.776.532.265'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.455.426.559'], ['G02.111.570.080.689.675', 'G05.360.080.689.675', 'G05.360.340.024.340.137.750.680'], ['D20.944.932', 'N06.850.460.710.865'],... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Evaluation of Cardiovascular Risk in Patient with Primary Non-alcoholic Fatty Liver Disease. | INTRODUCTION: The study aimed to investigate, in patients with primary non-alcoholic fatty liver disease (NAFLD), the presence of possible relationships between the degree of steatosis or fibrosis and the individual cardiovascular risk and possibly whether a difference between those various methods exists.METHODS: Thir... | ['Adult', 'Aged', 'Aged, 80 and over', 'Cardiovascular Diseases', 'Decision Support Techniques', 'Female', 'Humans', 'Liver Cirrhosis', 'Male', 'Middle Aged', 'Non-alcoholic Fatty Liver Disease', 'Prognosis', 'Risk Assessment', 'Risk Factors', 'Severity of Illness Index', 'Time Factors', 'Ultrasonography'] | 32,436,128 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C14'], ['E05.245', 'L01.313.500.750.190'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C06.552.630', 'C23.550.355.412'], ['M01.060.116.630'], ['C06.552.241.519'], ['E01.789'], ['E05.318.740.600.800.715', 'N04.452.871.715', 'N05.715.360.750.625.700... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Curriculum Development Around Parenting Strategies to Prevent and Respond to Child Sexual Abuse in Sub-Saharan Africa: A Program Collaboration Between Families Matter! and Global Dialogues. | Despite widespread recognition of child sexual abuse as a serious problem in sub-Saharan Africa, few far-reaching programmatic interventions addressing child sexual abuse in this setting are currently available, and those interventions that do exist tend to focus on response rather than prevention. The Families Matter!... | ['Africa South of the Sahara', 'Child', 'Child Abuse, Sexual', 'Female', 'Humans', 'Male', 'Models, Organizational', 'Parent-Child Relations', 'Parents', 'Primary Prevention', 'Program Evaluation', 'Risk Reduction Behavior'] | 26,701,277 | [['Z01.058.290'], ['M01.060.406'], ['I01.198.240.748.300', 'I01.198.240.856.350.250.255', 'I01.880.735.900.350.250.255'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.670', 'N04.452.534'], ['F01.829.263.370.290'], ['F01.829.263.500.320', 'I01.880.853.150.500.340', 'M01.620'], ['N02.421.726.758', 'N06.850.... | ['Geographicals [Z]', 'Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Identification of novel inhibitors of human Chk1 using pharmacophore-based virtual screening and their evaluation as potential anti-cancer agents. | Kinases are one of the major players in cancer development and progression. Serine threonine kinases such as human checkpoint kinase-1 (Chk1), Mek1 and cyclin-dependent kinases have been identified as promising targets for cancer treatment. Chk1 is an important kinase with vital role in cell cycle arrest and many poten... | ['Cell Line, Tumor', 'Checkpoint Kinase 1', 'DNA Damage', 'Humans', 'Neoplasms', 'Niacin', 'Phenylurea Compounds', 'Phosphorylation', 'Protein Kinase Inhibitors', 'Protein Kinases', 'User-Computer Interface'] | 25,312,395 | [['A11.251.210.190', 'A11.251.860.180'], ['D08.811.913.696.620.682.700.143'], ['G05.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04'], ['D03.066.515.475', 'D03.383.725.547.475'], ['D02.065.950.681', 'D02.455.426.559.389.703'], ['G02.111.665', 'G02.607.780', 'G03.796'], ['D27.505.519.389.755'], ['D08.811.9... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Information Science [L]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Characterization of serum lipoproteins of the shark Centrophorus squamous. | 1. Blood serum from the shark Centrophorus squamosus (Bonnaterre) was shown to contain VLD (very-low-density), LD (low-density) and HD (high-density) lipoproteins. 2. In shape, size and general physical properties, these lipoproteins were very similar to those described for other animals. The VLD lipoproteins were the ... | ['Amino Acids', 'Animals', 'Apolipoproteins', 'Chromatography, Gel', 'Electrophoresis, Polyacrylamide Gel', 'Fatty Acids', 'Glycerol', 'Lipids', 'Lipoproteins', 'Lipoproteins, VLDL', 'Sharks'] | 195,575 | [['D12.125'], ['B01.050'], ['D10.532.091', 'D12.776.070.400', 'D12.776.521.120'], ['E05.196.181.400.250'], ['E05.196.401.402', 'E05.301.300.319'], ['D10.251'], ['D02.033.800.875.500', 'D09.853.875.500'], ['D10'], ['D10.532', 'D12.776.521'], ['D10.532.599', 'D12.776.521.622'], ['B01.050.150.900.493.370.853']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Uptake of organic emergent contaminants in spath and lettuce: an in vitro experiment. | Although a myriad of organic microcontaminants may occur in irrigation waters, little attention has been paid to their incorporation in crops. In this work, a systematic approach to assess the final fate of both ionizable and neutral organic contaminants taken up by plants is described. In vitro uptake of triclosan (TC... | ['Araceae', 'Biological Transport', 'Food Contamination', 'Kinetics', 'Lettuce', 'Pharmaceutical Preparations', 'Water Pollutants, Chemical'] | 22,293,031 | [['B01.650.940.800.575.912.250.618.050.750'], ['G03.143'], ['J01.576.423.850.730.500.249', 'N06.850.460.400', 'N06.850.601.500.249'], ['G01.374.661', 'G02.111.490'], ['B01.650.940.800.575.912.250.100.500'], ['D26'], ['D27.888.284.903.655']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Human rhinovirus 87 identified as human enterovirus 68 by VP4-based molecular diagnosis. | Human rhinoviruses (HRVs) are the major cause of respiratory infections. We developed a diagnostic method for HRVs based on the reverse-transcription polymerase chain reaction (RT-PCR) and VP4-based phylogenetic analysis. A set of primers used in the RT-PCR of human enteroviruses (EVs) appeared to be capable of amplify... | ['Capsid Proteins', 'Enterovirus', 'Enterovirus D, Human', 'Enterovirus Infections', 'Humans', 'Molecular Sequence Data', 'Phylogeny', 'Reverse Transcriptase Polymerase Chain Reaction', 'Rhinovirus', 'Sequence Analysis, DNA'] | 12,403,917 | [['D12.776.964.970.600.550'], ['B04.820.578.750.284'], ['B04.820.578.750.284.188'], ['C01.925.782.687.359'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.453.245.667'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['E05.393.620.500.725'], ['B04.820.578.750.775'], ['E05.393.760.700']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Information Science [L]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Mitral valve repair with the new semirigid partial Colvin-Galloway Future annuloplasty band. | OBJECTIVE: Various devices have been proposed for ring stabilization in patients with mitral valve disease. This study reports the intermediate-term results of mitral valve repair with a new semirigid partial annuloplasty ring in a large series of patients.METHODS: A total of 437 consecutive patients were analyzed who ... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Female', 'Heart Valve Prosthesis', 'Heart Valve Prosthesis Implantation', 'Humans', 'Male', 'Middle Aged', 'Mitral Valve', 'Mitral Valve Insufficiency'] | 18,455,589 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E07.695.310'], ['E04.100.376.485', 'E04.650.410', 'E04.928.220.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['A07.541.510.507'], ['C14.280.484.461']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The 2 microm plasmid causes cell death in Saccharomyces cerevisiae with a mutation in Ulp1 protease. | The 2 microm circle plasmid confers no phenotype in wild-type Saccharomyces cerevisiae but in a nib1 mutant, an elevated plasmid copy number is associated with cell death. Complementation was used to identify nib1 as a mutant allele of the ULP1 gene that encodes a protease required for removal of a ubiquitin-like prote... | ['Alleles', 'Cell Division', 'Cell Nucleus', 'Cell Proliferation', 'Chromosome Segregation', 'Cysteine Endopeptidases', 'Fungal Proteins', 'G2 Phase', 'Gene Dosage', 'Genes, Reporter', 'Mutation', 'Phenotype', 'Plasmids', 'Protein Binding', 'Repressor Proteins', 'Saccharomyces cerevisiae', 'Saccharomyces cerevisiae Pro... | 15,870,298 | [['G05.360.340.024.340.030'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['G04.161.750', 'G07.345.249.410.750'], ['G04.144.220.220.625', 'G05.113.220.625'], ['D08.811.277.656.262.500', 'D08.811.277.656.300.200'], ['D12.776.354'], ['G04.1... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Assessing water distribution and agricultural expansion in the Cele Oasis, China. | Oases support 90% of the province's inhabitants and produce more than 95% of the social wealth in Xinjiang Province of China. Oases' dependency on water availability from mountainous regions plays a critical factor in the sustainability of agricultural practices and oasis expansion. In this study, we have chosen the Ce... | ['Agriculture', 'China', 'Desert Climate', 'Ecosystem', 'Environmental Monitoring', 'Water', 'Water Supply'] | 32,297,013 | [['J01.040'], ['Z01.252.474.164'], ['G16.500.275.071.325', 'N06.230.300.100.250.325'], ['G16.500.275.157', 'N06.230.124'], ['N06.850.460.350.080', 'N06.850.780.375'], ['D01.045.250.875', 'D01.248.497.158.459.650', 'D01.650.550.925'], ['J01.293.821.500']] | ['Technology, Industry, and Agriculture [J]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
Computed tomographic evaluation of traumatic spinal injuries. | A full radiological evaluation of patients who sustained traumatic injuries to the spine may be difficult to obtain due to the danger associated with manipulation. Computed tomography offers a new modality for simple and accurate evaluation; valuable information may be gained without the use of invasive methods. | ['Humans', 'Spinal Injuries', 'Tomography, X-Ray Computed'] | 663,187 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['C26.117.500'], ['E01.370.350.350.810', 'E01.370.350.600.350.700.810', 'E01.370.350.700.700.810', 'E01.370.350.700.810.810', 'E01.370.350.825.810.810']] | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Transformation by complementation of a uracil auxotroph of the hyper lignin-degrading basidiomycete Phanerochaete sordida YK-624. | Phanerochaete sordida YK-624 is a hyper lignin-degrading basidiomycete possessing greater ligninolytic selectivity than either P. chrysosporium or Trametes versicolor. To construct a gene transformation system for P. sordida YK-624, uracil auxotrophic mutants were generated using a combination of ultraviolet (UV) radia... | ['Gene Expression Regulation, Fungal', 'Genetic Complementation Test', 'Glyceraldehyde-3-Phosphate Dehydrogenases', 'Green Fluorescent Proteins', 'Industrial Microbiology', 'Lignin', 'Mutation', 'Orotate Phosphoribosyltransferase', 'Orotic Acid', 'Phanerochaete', 'Transformation, Genetic', 'Uracil'] | 17,701,036 | [['G05.308.330'], ['E05.393.281.526'], ['D08.811.682.657.163.750'], ['D12.776.532.265'], ['H01.158.273.540.460', 'J01.897.120.460'], ['D05.750.078.562.180.515', 'D05.750.078.687', 'D20.538', 'D25.720.099.687', 'J01.637.051.720.099.687'], ['G05.365.590'], ['D08.811.913.400.725.700'], ['D03.066.627', 'D03.383.742.698.875... | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
[Hypoxia promotes the differentiation of neural stem cells into dopaminergic neurons]. | Neural stem cells (NSCs) are multipotent and widely used in many research fields such as transplantation. Hypoxia not only improves the proliferation of various stem cells in vitro but also plays an important role in the differentiation of stem cells. The aim of the present study was to investigate the effect of hypoxi... | ['Animals', 'Cell Differentiation', 'Cell Hypoxia', 'Cells, Cultured', 'Dopamine', 'Female', 'Neurons', 'Rats', 'Rats, Wistar', 'Stem Cells', 'Tyrosine 3-Monooxygenase'] | 17,579,780 | [['B01.050'], ['G04.152'], ['G03.197.300', 'G04.270.300'], ['A11.251'], ['D02.092.211.215.406', 'D02.092.311.342', 'D02.455.426.559.389.657.166.175.342'], ['A08.675', 'A11.671'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.900'], ['A11.872'], ['D08.811.682.690.708.923', 'D12.7... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A qualitative study of the quality of life of children receiving intravenous nutrition at home. | OBJECTIVES: To discover the views of children with severe intestinal failure treated with intravenous nutrition from early life and who remained heavily dependent on treatment throughout childhood.METHODS: Seven children ages 7 to 17 years (mean 13 years) were interviewed. The diagnoses were enteropathy in 3, extreme s... | ['Adaptation, Psychological', 'Adolescent', 'Child', 'Family', 'Female', 'Gastrointestinal Diseases', 'Home Care Services', 'Humans', 'Interviews as Topic', 'Male', 'Parenteral Nutrition', 'Qualitative Research', 'Quality of Life', 'Resilience, Psychological'] | 20,179,643 | [['F01.058'], ['M01.060.057'], ['M01.060.406'], ['F01.829.263', 'I01.880.853.150'], ['C06.405'], ['N02.421.143.524', 'N02.421.539.089'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.420', 'L01.399.250.520', 'N05.715.360.300.400', 'N06.850.520.308.420'], ['E02.421.505', 'E02.642.500.505'], ['H01.770.64... | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Disciplines and Occupations [H]', 'Humanities [K]'... | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 |
Surgical management of malignant islet cell tumors. | The surgical management of pancreatic islet cell carcinomas poses a complicated set of questions resulting from their rare occurrence and the difficulty in establishing a diagnosis in early cases or, conversely, the problems inherent in dealing with metastatic disease. However, because their biologic behavior is rather... | ['Adenoma, Islet Cell', 'Glucagonoma', 'Humans', 'Pancreatic Neoplasms', 'Vipoma', 'Zollinger-Ellison Syndrome'] | 8,395,750 | [['C04.557.470.035.100', 'C04.588.274.761.249', 'C04.588.322.475.249', 'C06.301.761.249', 'C06.689.667.249', 'C19.344.421.249'], ['C04.557.470.200.025.290.750', 'C04.588.274.761.500.249', 'C04.588.322.475.500.249', 'C06.301.761.500.249', 'C06.689.667.500.249', 'C19.344.421.500.249'], ['B01.050.150.900.649.313.988.400.1... | ['Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Roles for interleukin-2 (IL-2) and IL-4 in the generation of allocytotoxic T cells in the primary and secondary responses in vitro. | Roles for interleukin-2 (IL-2) and IL-4 in the generation of murine allocytotoxine T lymphocytes (allo-CTL) in the primary and secondary responses were studied in vitro. The generation of allo-CTL in the primary response was inhibited by anti-IL-2 monoclonal antibody (mAb), but was not inhibited by anti-IL-4 mAb. On th... | ['Animals', 'Cells, Cultured', 'Female', 'Humans', 'Interleukin-2', 'Interleukin-4', 'Mice', 'Mice, Inbred BALB C', 'Mice, Inbred C3H', 'T-Lymphocytes, Cytotoxic'] | 1,547,862 | [['B01.050'], ['A11.251'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.465.021', 'D12.644.276.374.480.372', 'D12.776.467.374.465.021', 'D12.776.467.374.480.372', 'D23.529.374.465.155', 'D23.529.374.480.372'], ['D12.644.276.374.465.186', 'D12.776.467.374.465.178', 'D23.529.374.465.186'], ['B01.050... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Extracellular hemicellulolytic enzymes from the maize endophyte Acremonium zeae. | Microorganisms that colonize plants require a number of hydrolytic enzymes to help degrade the cell wall. The maize endophyte Acremonium zeae was surveyed for production of extracellular enzymes that hydrolyze cellulose and hemicellulose. The most prominent enzyme activity in cell-free culture medium from A. zeae NRRL ... | ['Acremonium', 'Cellulases', 'Electrophoresis, Polyacrylamide Gel', 'Fungal Proteins', 'Molecular Weight', 'Polysaccharides', 'Xylans', 'Zea mays'] | 19,184,610 | [['B01.300.381.025'], ['D08.811.277.450.420.200'], ['E05.196.401.402', 'E05.301.300.319'], ['D12.776.354'], ['G02.494'], ['D09.698'], ['D09.698.925'], ['B01.650.940.800.575.912.250.822.966']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Recognition of variable courtship song in the field cricket Gryllus assimilis. | We analyzed the courtship song of the field cricket Gryllus assimilis. The song comprises two elements: groups of ca. 10 pulses (chirps) with low fundamental frequency (3.5-3.7 kHz) alternating with high-frequency (15-17 kHz) pulses (ticks) that usually occur as doublets. Some elements of courtship song are quite varia... | ['Animals', 'Courtship', 'Female', 'Gryllidae', 'Interneurons', 'Male', 'Sexual Behavior, Animal', 'Vocalization, Animal'] | 22,675,181 | [['B01.050'], ['F01.145.802.279'], ['B01.050.500.131.617.678.410'], ['A08.675.358', 'A11.671.358'], ['F01.145.113.252.748'], ['F01.145.113.055.800']] | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
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