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Validation and application of a novel integrated genetic screening method to a cohort of 1,112 men with idiopathic azoospermia or severe oligozoospermia. | Microdeletions of the Y chromosome (YCMs), Klinefelter syndrome (47,XXY), and CFTR mutations are known genetic causes of severe male infertility, but the majority of cases remain idiopathic. Here, we describe a novel method using single molecule Molecular Inversion Probes (smMIPs), to screen infertile men for mutations... | ['Azoospermia', 'Chromosome Aberrations', 'Computational Biology', 'DNA Copy Number Variations', 'Genetic Association Studies', 'Genetic Predisposition to Disease', 'Genetic Testing', 'High-Throughput Nucleotide Sequencing', 'Humans', 'Male', 'Mutation', 'Oligospermia', 'Phenotype', 'Reproducibility of Results', 'Sever... | 28,801,929 | [['C12.294.365.700.380'], ['C23.550.210', 'G05.365.590.175'], ['H01.158.273.180', 'L01.313.124'], ['G05.365.795.297.500'], ['E05.393.385'], ['C23.550.291.687.500', 'G05.380.355'], ['E01.370.225.562', 'E05.200.562', 'E05.393.435', 'N02.421.308.430', 'N02.421.726.233.221'], ['E05.393.760.319'], ['B01.050.150.900.649.313.... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Flexible matching in case-control studies of gene-environment interactions. | Because of the lack of power of case-control study designs to detect gene-environment interactions, flexible matching has recently been proposed as a method of improving efficiency. In this paper, the authors consider a large-sample approximation method that allows estimation of the most efficient matching strategy whe... | ['Case-Control Studies', 'Computer Simulation', 'Environmental Exposure', 'Epidemiologic Methods', 'Genetic Predisposition to Disease', 'Humans', 'Neoplasms', 'Research Design', 'Statistics as Topic'] | 14,693,655 | [['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['L01.224.160'], ['N06.850.460.350'], ['E05.318', 'N06.850.520'], ['C23.550.291.687.500', 'G05.380.355'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04'], ['E05.581.500', 'H01.770.644.728'], ['E05.318.740', 'H01.548.832', 'N05.715.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Information Science [L]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Neurotensin (NTS) and its receptor (NTSR1) causes EGFR, HER2 and HER3 over-expression and their autocrine/paracrine activation in lung tumors, confirming responsiveness to erlotinib. | Alterations in the signaling pathways of epidermal growth factor receptors (HERs) are associated with tumor aggressiveness. Neurotensin (NTS) and its high affinity receptor (NTSR1) are up regulated in 60% of lung cancers. In a previous clinical study, NTSR1 overexpression was shown to predict a poor prognosis for 5 yea... | ['Adenocarcinoma', 'Adenocarcinoma of Lung', 'Aged', 'Animals', 'Autocrine Communication', 'Cell Line, Tumor', 'Cell Proliferation', 'Chemotherapy, Adjuvant', 'ErbB Receptors', 'Erlotinib Hydrochloride', 'Female', 'Heparin-binding EGF-like Growth Factor', 'Humans', 'Kaplan-Meier Estimate', 'Lung Neoplasms', 'Male', 'Ma... | 25,249,545 | [['C04.557.470.200.025'], ['C04.557.470.200.025.022', 'C04.588.894.797.520.055'], ['M01.060.116.100'], ['B01.050'], ['G04.085.100'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.161.750', 'G07.345.249.410.750'], ['E02.186.170', 'E02.319.170'], ['D08.811.913.696.620.682.725.400.009', 'D12.776.543.750.630.009', 'D12.776... | ['Diseases [C]', 'Named Groups [M]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Leprosy patients: neurotrophic factors and axonal markers in skin lesions. | Neurotrophins are growth factors with crucial roles in neural pathophysiology. These mediators functionally modulate nociceptive fibers, and changes in neurotrophins expression have been correlated with early loss of nociception in leprosy. This study investigated the expression of NGF, BDNF, and NT3 in dermal nerves o... | ['Biomarkers', 'Brain-Derived Neurotrophic Factor', 'Case-Control Studies', 'Enzyme-Linked Immunospot Assay', 'Humans', 'Immunohistochemistry', 'Leprosy', 'Nerve Growth Factor', 'Neurotrophin 3', 'Skin'] | 22,510,739 | [['D23.101'], ['D12.644.276.860.100', 'D12.776.467.860.100', 'D12.776.631.600.100', 'D23.529.850.100'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['E01.370.225.500.508', 'E05.200.500.508', 'E05.242.551', 'E05.478.566.350.170.500', 'E05.478.566.380.360.500', 'E05.478.583.400.170.500'... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Detection of tuberculosis: respiratory symptoms flow and results achieved. | OBJECTIVE: to analyze the flow of care to the person with symptoms of tuberculosis and the results achieved in the detection of cases in Primary Health Care units of two municipalities of Rio Grande do Sul.METHOD: descriptive of mixed methods, developed between 2013 and 2016. We used secondary data of 69 units and semi... | ['Brazil', 'Humans', 'Mass Screening', 'Primary Health Care', 'Qualitative Research', 'Tuberculin Test', 'Tuberculosis'] | 30,304,188 | [['Z01.107.757.176'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.500', 'E05.318.308.980.438.580', 'N02.421.726.233.443', 'N05.715.360.300.800.438.500', 'N06.850.520.308.980.438.580', 'N06.850.780.500'], ['N04.590.233.727'], ['H01.770.644.241.850'], ['E01.370.225.812.871.800', 'E05.200.812.871.800', 'E05... | ['Geographicals [Z]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
Transcatheter adrenal arterial embolization of cortisol-producing tumors. Two cases of Cushing's syndrome. | Transcatheter arterial embolization (TAE) was performed in 2 patients with Cushing's syndrome caused by adrenal adenoma by using a mixture of absolute ethanol and iohexol. In 1 patient successful suppression of the hypersecretion of cortisol has continued for 9 months after TAE without complications. However, in the ot... | ['Adenoma', 'Adrenal Gland Neoplasms', 'Adult', 'Angiography', 'Cushing Syndrome', 'Embolization, Therapeutic', 'Ethanol', 'Female', 'Humans', 'Hydrocortisone', 'Iohexol', 'Middle Aged', 'Paraneoplastic Endocrine Syndromes', 'Tomography, X-Ray Computed'] | 9,973,912 | [['C04.557.470.035'], ['C04.588.322.078', 'C19.053.347', 'C19.344.078'], ['M01.060.116'], ['E01.370.350.700.060', 'E01.370.370.050'], ['C19.053.800.367'], ['E02.520.360', 'E02.926.500'], ['D02.033.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D04.210.500.745.745.654.600', 'D06.472.040.585.353.476', 'D06.472... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[A rare aetiology of the post-partum fever: ovarian vein thrombophlebitis]. | OBJECTIVES: To clarify the contribution of the doppler and the CT in the balance aetiology of a fever of the post-partum and to connect it with a thrombophlebitis of ovarian vein.PATIENTS AND METHODS: Five patients presented there post-partum a fever with pointed abdominal painful syndrome. A doppler and a CT were perf... | ['Abdominal Pain', 'Adult', 'Cefotaxime', 'Cephalosporins', 'Female', 'Fever', 'Humans', 'Ovarian Diseases', 'Ovary', 'Postpartum Period', 'Regional Blood Flow', 'Thrombophlebitis', 'Tomography, X-Ray Computed', 'Ultrasonography'] | 16,377,122 | [['C23.888.592.612.054', 'C23.888.821.030'], ['M01.060.116'], ['D02.065.589.099.249.190.190', 'D02.886.665.074.190.190', 'D03.633.100.300.249.190.190'], ['D02.065.589.099.249', 'D02.886.665.074', 'D03.633.100.300.249'], ['C23.888.119.344'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C13.351.500.056.630', 'C19.3... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Antitrypanosomal compounds from the essential oil and extracts of Keetia leucantha leaves with inhibitor activity on Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase. | Keetia leucantha is a West African tree used in traditional medicine to treat several diseases among which parasitic infections. The dichloromethane extract of leaves was previously shown to possess growth-inhibitory activities on Plasmodium falciparum, Trypanosoma brucei brucei and Leishmania mexicana mexicana with lo... | ['Glyceraldehyde-3-Phosphate Dehydrogenases', 'Oils, Volatile', 'Parasitic Sensitivity Tests', 'Phytotherapy', 'Plant Extracts', 'Plant Leaves', 'Plants, Medicinal', 'Rubiaceae', 'Trypanocidal Agents', 'Trypanosoma brucei brucei'] | 23,312,849 | [['D08.811.682.657.163.750'], ['D10.627.675'], ['E01.370.225.940', 'E05.200.940', 'E05.337.550.700'], ['E02.190.755'], ['D20.215.784.500', 'D26.667'], ['A18.024.812'], ['B01.650.560'], ['B01.650.940.800.575.912.250.456.937'], ['D27.505.954.122.250.100.875'], ['B01.268.475.868.887.080']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Continuous regional anaesthesia in infants. | Physiological immaturity of the respiratory musculature and central respiratory control centres leads to an increased risk of apnoea and respiratory complications following general anaesthesia in neonates. Regional anaesthetic techniques may obviate the need for general anaesthesia and lessen the risks of perioperative... | ['Anesthesia, Caudal', 'Anesthesia, Spinal', 'Anesthetics, Local', 'Bronchopulmonary Dysplasia', 'Bupivacaine', 'Catheters, Indwelling', 'Circumcision, Male', 'Hernia, Inguinal', 'Hernia, Umbilical', 'Humans', 'Infant', 'Infant, Newborn', 'Infant, Premature', 'Infant, Premature, Diseases', 'Male', 'Monitoring, Intraope... | 8,269,568 | [['E03.155.086.131.100'], ['E03.155.086.331'], ['D27.505.696.277.100.200', 'D27.505.696.663.850.025', 'D27.505.954.427.210.100.200'], ['C08.381.520.750.500', 'C16.614.521.125'], ['D02.065.199.239', 'D02.092.146.113.239'], ['E07.132.500'], ['E02.218.085.170', 'E04.085.170', 'E04.950.774.860.226'], ['C23.300.707.374.875'... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Longitudinal changes in intake and food sources of calcium from childhood to young adulthood: the bogalusa heart study. | OBJECTIVE: To examine changes in calcium intake and food sources of calcium from childhood to young adulthood in a longitudinal sample.METHODS: Information on food and nutrient intake was derived from a single 24-hour dietary recall collected on children who participated in a cross-sectional survey at age 10 and again ... | ['Adolescent', 'Adult', 'African Americans', 'Analysis of Variance', 'Calcium, Dietary', 'Child', 'Cohort Studies', 'Cross-Sectional Studies', 'European Continental Ancestry Group', 'Feeding Behavior', 'Female', 'Health Promotion', 'Humans', 'Longitudinal Studies', 'Louisiana', 'Male', 'Mental Recall', 'Nutrition Polic... | 15,310,738 | [['M01.060.057'], ['M01.060.116'], ['M01.686.508.100.100', 'M01.686.754.100'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['D01.146.395'], ['M01.060.406'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.5... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Special histologic stains are rarely beneficial for the evaluation of HIV-related gastrointestinal infections. | During a 28-month period, endoscopic mucosal biopsy specimens from all HIV-infected patients were submitted for routine histologic evaluation. Immunoperoxidase staining for cytomegalovirus and herpesvirus antigens (esophagus), mycobacterial and fungal staining, and Gram staining of mucosal biopsy specimens were done. S... | ['AIDS-Related Opportunistic Infections', 'Adult', 'Biopsy', 'Candida', 'Candidiasis', 'Cost-Benefit Analysis', 'Cytomegalovirus', 'Cytomegalovirus Infections', 'Endoscopy', 'Female', 'Follow-Up Studies', 'Gastric Mucosa', 'HIV Enteropathy', 'Herpes Simplex', 'Humans', 'Immunoenzyme Techniques', 'Intestinal Mucosa', 'M... | 10,989,639 | [['C01.221.250.875.100', 'C01.597.050', 'C01.610.684.050', 'C01.925.597.050', 'C01.925.782.815.616.400.100', 'C20.673.480.100'], ['M01.060.116'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['B01.300.107.795.095', 'B01.30... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Segmental enhancement inversion of small renal oncocytoma: differences in prevalence according to tumor size. | OBJECTIVE: The purpose of this study was to retrospectively assess the prevalence of segmental enhancement inversion of small renal oncocytomas according to tumor size.MATERIALS AND METHODS: Thirty-three patients (19 men, 14 women; mean age, 61 years; range, 40-74 years) with 33 oncocytomas diagnosed at surgical resect... | ['Adenoma, Oxyphilic', 'Adult', 'Aged', 'Female', 'Humans', 'Imaging, Three-Dimensional', 'Kidney Neoplasms', 'Male', 'Middle Aged', 'Prevalence', 'Reproducibility of Results', 'Republic of Korea', 'Sensitivity and Specificity', 'Tomography, X-Ray Computed', 'Tumor Burden'] | 23,617,489 | [['C04.557.470.035.140'], ['M01.060.116'], ['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.400', 'L01.224.308.410'], ['C04.588.945.947.535', 'C12.758.820.750', 'C12.777.419.473', 'C13.351.937.820.535', 'C13.351.968.419.473'], ['M01.060.116.630'], ['E05.318.308.985.525.750', 'N01.224.... | ['Diseases [C]', 'Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]', 'Geographicals [Z]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
The effect of posterior thoracic spine anatomical structures on motion segment flexion stiffness. | STUDY DESIGN: This in vitro human cadaveric study tested the loss of thoracic motion segment flexion stiffness after sequential posterior upper instrumented vertebra anchor placement techniques and posterior column destabilization.OBJECTIVE: This study was designed to determine the possible destabilizing effects of upp... | ['Aged', 'Aged, 80 and over', 'Biomechanical Phenomena', 'Bone Screws', 'Female', 'Humans', 'In Vitro Techniques', 'Kyphosis', 'Ligaments', 'Male', 'Middle Aged', 'Postoperative Complications', 'Prevalence', 'Range of Motion, Articular', 'Risk Factors', 'Scoliosis', 'Spinal Fusion', 'Thoracic Vertebrae'] | 19,247,164 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['G01.154.090', 'G01.374.089'], ['E07.695.370.437', 'E07.858.442.660.460.437', 'E07.858.690.725.460.437'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.481'], ['C05.116.900.800.500'], ['A02.513', 'A10.165.669'], ['M01.060.116.630'], ['C23.550.767'], ['E05.318.308... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Rac1 pathway mediates stretch response in pulmonary alveolar epithelial cells. | Alveolar epithelial cells (AECs) maintain the pulmonary blood-gas barrier integrity with gasketlike intercellular tight junctions (TJ) that are anchored internally to the actin cytoskeleton. We have previously shown that AEC monolayers stretched cyclically and equibiaxially undergo rapid magnitude- and frequency-depend... | ['Androstadienes', 'Animals', 'Chimerin Proteins', 'Cytoskeleton', 'Epithelial Cells', 'Lim Kinases', 'Phosphorylation', 'Platelet-Derived Growth Factor', 'Protein Kinase Inhibitors', 'Proto-Oncogene Proteins c-akt', 'Pulmonary Alveoli', 'Pyrones', 'Quinolines', 'Rats', 'Rats, Sprague-Dawley', 'Respiratory Mucosa', 'Si... | 23,686,855 | [['D04.210.500.054.079.129'], ['B01.050'], ['D12.644.360.325.150.100', 'D12.776.476.325.150.100', 'D12.776.631.124'], ['A11.284.430.214.190.750'], ['A11.436'], ['D08.811.913.696.620.682.700.542', 'D12.644.360.390', 'D12.776.476.396', 'D12.776.512.124'], ['G02.111.665', 'G02.607.780', 'G03.796'], ['D12.644.276.910', 'D1... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Changes in the polyelectrolyte-amphiphile interaction due to helix-coil transition induced by specific counterions or variations in temperature. | For the system kappa-carrageenan/amitriptyline it is shown that the degree of binding of amitriptyline is closely related to the carrageenan conformation as regulated by the counterions (Na+ or K+). The adsorption becomes much more pronounced when the carrageenan molecule is in the helix form (counterion K+) than when ... | ['Amitriptyline', 'Antidepressive Agents, Tricyclic', 'Biopolymers', 'Carbohydrate Sequence', 'Carrageenan', 'Electrolytes', 'Ions', 'Molecular Conformation', 'Molecular Sequence Data', 'Temperature'] | 8,756,518 | [['D02.455.426.559.847.181.384.100', 'D04.615.181.384.100'], ['D27.505.954.427.700.122.055'], ['D05.750.078', 'D25.720.099', 'J01.637.051.720.099'], ['G02.111.570.160', 'L01.453.245.667.160'], ['D09.698.152'], ['D01.248'], ['D01.248.497'], ['G02.111.570.820'], ['L01.453.245.667'], ['G01.906.595', 'G16.500.275.063.725.7... | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 |
Amniotic membrane transplantation to reconstruct the conjunctival surface in cases of chemical burn. | PURPOSE: To evaluate the efficiency of preserved human amniotic membrane transplantation for conjunctival surface reconstruction in cases of chemical burn.METHODS: Preserved amniotic membrane transplantation was performed in 6 patients (6 eyes) having symblepharon and fornix insufficiency due to chemical burn. Amniotic... | ['Adolescent', 'Adult', 'Alkalies', 'Amnion', 'Burns, Chemical', 'Conjunctiva', 'Eye Burns', 'Female', 'Fibrosis', 'Humans', 'Male', 'Recurrence'] | 12,967,871 | [['M01.060.057'], ['M01.060.116'], ['D01.045'], ['A10.615.284.277', 'A16.254.750.277'], ['C26.200.156'], ['A09.371.060.200', 'A09.371.337.168'], ['C10.900.300.284.250.250', 'C26.200.503', 'C26.915.300.425.250.250'], ['C23.550.355'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.291.937']] | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Correlative measurement of four biological contaminants on cotton lint, and their implications for occupational health. | Four biological contaminants of cotton fibers (gram-negative bacterial cells, endotoxin, fungal cells, and (1-3)-beta-D-glucan) were measured in 13 cotton lint samples from international origins, using traditional microbiological spread plating and adaptation of the Limulus amoebocyte lysate (LAL) assay. Correlations w... | ['Cotton Fiber', 'Fungi', 'Gram-Negative Bacteria', 'Lipopolysaccharides', 'Occupational Exposure', 'Statistics, Nonparametric', 'beta-Glucans'] | 16,722,191 | [['J01.637.836.299'], ['B01.300'], ['B03.440'], ['D09.400.500', 'D09.698.718.450', 'D10.494', 'D23.050.161.616.525', 'D23.946.123.329.500'], ['N06.850.460.350.600'], ['E05.318.740.995', 'N05.715.360.750.760', 'N06.850.520.830.995'], ['D09.698.365.089']] | ['Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Numerical design of electrical-mechanical traps. | We present a coupled immersed interface method-boundary element method (IIM-BEM) numerical technique that predicts the behaviour of deformable cells under the effect of both hydrodynamic and electrical forces. This technique is applied to the study of a hybrid electrical-mechanical trap for single-cell trapping. We rep... | ['Algorithms', 'Electrodes', 'Electromagnetic Fields', 'Electrophoresis, Microchip', 'Equipment Design', 'Microarray Analysis', 'Models, Biological', 'Particle Size', 'Viscosity'] | 18,432,346 | [['G17.035', 'L01.224.050'], ['E07.305.250'], ['G01.358.500.260', 'G01.358.750.500'], ['E05.196.401.190.500', 'E05.588.465.340'], ['E05.320'], ['E05.588.570'], ['E05.599.395'], ['G02.712'], ['G02.930']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Outcome of directly observed therapy for tuberculosis in Yokohama City, Japan. | BACKGROUND: Yokohama City is currently developing directly observed treatment (DOT) in its programme, and requires guidance on types of DOT appropriate for local conditions.OBJECTIVE: To assess the effectiveness of DOT for tuberculosis treatment in a retrospective study under operational conditions in Yokohama City.MET... | ['Antitubercular Agents', 'Directly Observed Therapy', 'Humans', 'Japan', 'Logistic Models', 'Middle Aged', 'Multivariate Analysis', 'Patient Compliance', 'Program Evaluation', 'Retrospective Studies', 'Self Administration', 'Treatment Outcome', 'Tuberculosis, Pulmonary'] | 12,921,148 | [['D27.505.954.122.085.255'], ['F01.100.150.750.500.600.500.500', 'F01.145.488.887.500.600.500.500', 'N05.300.150.800.500.600.500.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.474.463', 'Z01.639.595'], ['E05.318.740.500.525', 'E05.318.740.600.800.450', 'E05.318.740.750.450', 'E05.599.835.875', 'N05.... | ['Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Hepatic heparan sulphate proteoglycan and the recycling of transferrin. | Heparan sulphate proteoglycan, labelled with [35S]sulphate, was prepared from rat livers for studies of its interaction with purified rat transferrin. Affinity chromatography of the preparation on columns of immobilized differic transferrin and apotransferrin showed that the proteoglycan possessed affinity for both typ... | ['Animals', 'Apoproteins', 'Chromatography, Affinity', 'Heparan Sulfate Proteoglycans', 'Heparitin Sulfate', 'Hydrogen-Ion Concentration', 'Iron', 'Liver', 'Proteoglycans', 'Rats', 'Receptors, Transferrin', 'Transferrin'] | 1,449,722 | [['B01.050'], ['D12.776.070'], ['E05.196.181.400.170'], ['D09.698.373.425.500', 'D09.698.735.400', 'D12.776.395.650.350'], ['D09.698.373.425'], ['G02.300'], ['D01.268.556.412', 'D01.268.956.287', 'D01.552.544.412'], ['A03.620'], ['D09.698.735', 'D12.776.395.650'], ['B01.050.150.900.649.313.992.635.505.700'], ['D12.776.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Sesquiterpene lactones from Carpesium abrotanoides. | Phytochemical study on the ethanol extract of the aerial parts of Carpesium abrotanoides led to the isolation of two new sesquiterpene lactones, carabrolactone A (1) and carabrolactone B (2). Their structures were elucidated on the basis of extensive spectroscopic analysis. | ['Asteraceae', 'Lactones', 'Molecular Structure', 'Plant Components, Aerial', 'Sesquiterpenes'] | 18,948,175 | [['B01.650.940.800.575.912.250.100'], ['D02.540'], ['G02.111.570', 'G02.466'], ['A18.024'], ['D02.455.849.765']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Genetically diverse herpesviruses in South American Atlantic coast seabirds. | Different herpesviruses have been associated with respiratory and enteric disease and mortality among seabirds and waterfowl. In 2011, a respiratory disease outbreak affected 58.3% (98/168) of the Magellanic penguins undergoing rehabilitation due to an oil spill off the southern Brazilian coast. Etiology was attributed... | ['Animals', 'Atlantic Ocean', 'Bird Diseases', 'Disease Outbreaks', 'Genetic Variation', 'Herpesviridae', 'Phylogeny', 'Polymerase Chain Reaction', 'South America', 'Spheniscidae'] | 28,575,104 | [['B01.050'], ['Z01.756.092'], ['C22.131'], ['N06.850.290'], ['G05.365'], ['B04.280.382'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['E05.393.620.500'], ['Z01.107.757'], ['B01.050.150.900.248.860']] | ['Organisms [B]', 'Geographicals [Z]', 'Diseases [C]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 |
Near infrared (NIR) lanthanide emissive Langmuir-Blodgett monolayers formed using Nd(III) directed self-assembly synthesis of chiral amphiphilic ligands. | The incorporation of chiral amphiphilic lanthanide-directed self-assembled Nd(III) complexes (Nd.13 and Nd.23) into stable Langmuir monolayers, and the subsequent Langmuir-Blodgett film formation of these, is described. The photophysical properties of the enantiomeric pair of ligands 1 and 2 in the presence of Nd(CF3SO... | ['Hydrogen Bonding', 'Hydrophobic and Hydrophilic Interactions', 'Infrared Rays', 'Lanthanoid Series Elements', 'Ligands', 'Models, Molecular', 'Molecular Conformation', 'Neodymium', 'Stereoisomerism'] | 23,980,548 | [['G02.282'], ['G02.409'], ['G01.358.500.505.650.552', 'G01.590.540.552', 'G01.750.250.650.552', 'G01.750.770.578.552', 'G16.500.275.063.725.525.400', 'G16.500.750.775.525.400', 'N06.230.300.100.725.525.400'], ['D01.268.558.362', 'D01.552.550.399'], ['D27.720.470.480'], ['E05.599.595'], ['G02.111.570.820'], ['D01.268.5... | ['Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Kinetic properties of the isoenzymes of human creatine phosphokinase. | Studies of the three human creatine phosphokinase (EC 2.7.3.2) isoenzymes, MM, MB, and BB, show that important differences exist in substrate dependency of the reaction rates. A method was developed to study these properties in which the ATP formed in the reverse reaction was measured by means of firefly luciferase. Wi... | ['Adenosine Triphosphate', 'Creatine Kinase', 'Diagnosis, Differential', 'Humans', 'Insecta', 'Isoenzymes', 'Kinetics', 'Luciferases', 'Luminescent Measurements', 'Myocardial Infarction'] | 4,524,644 | [['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['D08.811.913.696.640.150'], ['E01.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.500.131.617'], ['D08.811.348', 'D12.776.800.300'], ['G01.374.661', 'G02.111.490'], ['D08.811.682.517', 'D12.776.532.510'], ['E05.196.712.51... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Association of SNP3 polymorphism in the apolipoprotein A-V gene with plasma triglyceride level in Tunisian type 2 diabetes. | BACKGROUND: Apolipoprotein A-V (Apo A-V) gene has recently been identified as a new apolipoprotein involved in triglyceride metabolism. A single nucleotide polymorphism (SNP3) located in the gene promoter (-1131) was associated with triglyceride variation in healthy subjects. In type 2 diabetes the triglyceride level i... | ['Aged', 'Apolipoproteins', 'Coronary Artery Disease', 'Diabetes Mellitus, Type 2', 'Female', 'Genotype', 'Humans', 'Male', 'Middle Aged', 'Polymorphism, Single Nucleotide', 'Risk Factors', 'Triglycerides', 'Tunisia'] | 15,636,639 | [['M01.060.116.100'], ['D10.532.091', 'D12.776.070.400', 'D12.776.521.120'], ['C14.280.647.250.260', 'C14.907.137.126.339', 'C14.907.585.250.260'], ['C18.452.394.750.149', 'C19.246.300'], ['G05.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['G05.365.795.598'], ['E05.318.740.600.800.725', ... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
[The effect of a supplement of citric acid on the bioavailability of zinc from corn germ]. | The purpose of this 2 factorial designed study was to investigate the influence of citric acid on the availability of zinc from diets containing 140 g corn germs as a native phytate source (0.5% phytate in diet). Growing male rats with an average initial weight of 42 g were divided into 8 groups of 8 animals each. Afte... | ['Alkaline Phosphatase', 'Animals', 'Biological Availability', 'Citrates', 'Citric Acid', 'Diet', 'Femur', 'Intestine, Small', 'Liver', 'Male', 'Metallothionein', 'Phytic Acid', 'Rats', 'Zea mays', 'Zinc'] | 2,333,719 | [['D08.811.277.352.650.035'], ['B01.050'], ['G03.787.151', 'G07.690.725.129'], ['D02.241.081.901.434'], ['D02.241.081.901.434.249'], ['G07.203.650.240'], ['A02.835.232.043.150'], ['A03.556.124.684'], ['A03.620'], ['D12.776.556.670'], ['D02.033.800.519.400.700', 'D09.853.519.400.700', 'D09.894.480.700'], ['B01.050.150.9... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
An unusual lawn mower injury. | The authors report a case of foot trauma produced by a piece of the lawn mower blade, which was fired projectile-wise from the machine while it was in operation. At hit the calcaneous and remained trapped in the bone. The wound healed after removal of the foreign body, wound debridement and systemic and local antibioti... | ['Accidents, Home', 'Adult', 'Antibiotic Prophylaxis', 'Calcaneus', 'External Fixators', 'Foot Injuries', 'Foreign Bodies', 'Fracture Healing', 'Humans', 'Male', 'Radiography', 'Wounds, Penetrating'] | 8,881,231 | [['N06.850.135.217'], ['M01.060.116'], ['E02.319.162.150', 'E02.319.703.150'], ['A02.835.232.043.300.710.300'], ['E07.858.442.660.430', 'E07.858.690.725.430'], ['C26.558.300'], ['C26.392'], ['G16.762.891.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.700'], ['C26.986']] | ['Health Care [N]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Effects of anodal transcranial direct current stimulation over lower limb primary motor cortex on motor learning in healthy individuals. | Transcranial direct current stimulation (tDCS) is a neuromodulatory technique which alters motor functions in healthy humans and in neurological patients. Most studies so far investigated the effects of tDCS on mechanisms underlying improvements in upper limb performance. To investigate the effect of anodal tDCS over t... | ['Adult', 'Female', 'Healthy Volunteers', 'Humans', 'Learning', 'Lower Extremity', 'Male', 'Motor Cortex', 'Psychomotor Performance', 'Single-Blind Method', 'Transcranial Direct Current Stimulation', 'Young Adult'] | 29,443,433 | [['M01.060.116'], ['M01.774.500', 'M01.955.236'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.425', 'F02.784.629.529'], ['A01.378.610'], ['A08.186.211.200.885.287.500.270.548', 'A08.186.211.200.885.287.500.814.624'], ['F02.808', 'G11.427.700', 'G11.561.660'], ['E05.318.370.850', 'N05.715.360.325.730', 'N... | ['Named Groups [M]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Coronary-pulmonary artery fistula associated with right heart failure: successful closure of fistula with a graft stent. | Coronary artery fistula constitutes a rare congenital anomaly. The reported incidence of this anomaly ranges from 0.1% to 0.2% of the population undergoing coronary angiography. Coronary-pulmonary artery fistula is an extremely rare congenital anomaly of the coronary artery. Its real incidence is unknown. The authors r... | ['Aged', 'Arterio-Arterial Fistula', 'Coronary Angiography', 'Coronary Vessel Anomalies', 'Echocardiography', 'Echocardiography, Doppler', 'Female', 'Follow-Up Studies', 'Heart Failure', 'Humans', 'Polytetrafluoroethylene', 'Pulmonary Artery', 'Stents', 'Time Factors'] | 12,365,873 | [['M01.060.116.100'], ['C14.240.850.984.500', 'C14.907.933.110', 'C16.131.240.850.500', 'C23.300.575.950.150'], ['E01.370.350.130.625', 'E01.370.350.700.060.200', 'E01.370.370.050.200', 'E01.370.370.380.200'], ['C14.240.400.210', 'C14.280.400.210', 'C16.131.240.400.210'], ['E01.370.350.130.750', 'E01.370.350.850.220', ... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
MiRNA-615-5p functions as a tumor suppressor in pancreatic ductal adenocarcinoma by targeting AKT2. | BACKGROUND: Aberrant microRNA (miRNA) expression is associated with tumor development. This study aimed to elucidate the role of miR-615-5p in the development of pancreatic ductal adenocarcinoma (PDAC).METHODS: Locked nucleic acid in situ hybridization (LNA-ISH) was performed to compare miR-615-5p expression in patient... | ['Adenocarcinoma', 'Animals', 'Apoptosis', 'Base Sequence', 'Cell Line, Tumor', 'Cell Movement', 'Cell Proliferation', 'Cell Transformation, Neoplastic', 'Female', 'Gene Expression Regulation, Neoplastic', 'Genes, Tumor Suppressor', 'Humans', 'Kaplan-Meier Estimate', 'Male', 'Mice', 'MicroRNAs', 'Middle Aged', 'Neoplas... | 25,856,297 | [['C04.557.470.200.025'], ['B01.050'], ['G04.146.954.035'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.198', 'G07.568.500.180'], ['G04.161.750', 'G07.345.249.410.750'], ['C04.697.098.500', 'C23.550.727.098.500'], ['G05.308.370'], ['G05.360.340.024.340.375.24... | ['Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Named Groups [M]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Estimated radiation doses to different organs among patients treated for ankylosing spondylitis with a single course of X rays. | A follow-up study of over 14,000 patients treated with a single course of X rays for ankylosing spondylitis demonstrated a substantial excess risk of developing cancer. Previously the excess risk of leukaemia has been related to the estimated mean radiation dose to the active bone marrow but detailed estimates were not... | ['Adult', 'Bone Marrow', 'Digestive System', 'Female', 'Humans', 'Lung', 'Male', 'Middle Aged', 'Monte Carlo Method', 'Radiation Dosage', 'Spondylitis, Ankylosing', 'Whole-Body Counting'] | 3,126,852 | [['M01.060.116'], ['A15.382.216'], ['A03'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A04.411'], ['M01.060.116.630'], ['E05.318.740.525', 'L01.906.394.422', 'N05.715.360.750.540', 'N06.850.520.830.525'], ['E05.799.513', 'G01.750.740', 'N06.850.810.250'], ['C05.116.900.853.625.800.850', 'C05.550.069.680', 'C05.... | ['Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Use of miswak versus toothbrushes: oral health beliefs and behaviours among a sample of Jordanian adults. | OBJECTIVE: This descriptive survey aimed at determining the perceived relationship among miswak, the toothbrush, and toothbrush-plus-miswak usage on oral health beliefs and behaviours of Jordanian adults, 18-60 years old, seeking dental care in the city of Irbid, northern Jordan.METHODS: Patients (n = 138) voluntarily ... | ['Adolescent', 'Adult', 'Age Factors', 'Chi-Square Distribution', 'Educational Status', 'Female', 'Health Behavior', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Jordan', 'Male', 'Middle Aged', 'Office Visits', 'Oral Health', 'Oral Hygiene', 'Reproducibility of Results', 'Salvadoraceae', 'Sex Factors', 'Surveys ... | 16,451,363 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['N01.824.196'], ['F01.145.488'], ['F01.100.150.500', 'N05.300.150.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.245.500.400'], ['M... | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
A study of microemboli monitoring of atherosclerotic thrombotic cerebral infarction and artery stenosis. | This study aimed to assess the relationship between the recurrence and prognosis of patients with acute middle cerebral artery infarction, atherosclerotic brain infarction, and the existence of microemboli. We continuously enrolled patients with acute atherosclerotic thrombotic cerebral infarction artery stenosis. We p... | ['Aged', 'Analysis of Variance', 'Carotid Arteries', 'Cerebral Arterial Diseases', 'Constriction, Pathologic', 'Embolism', 'Female', 'Humans', 'Infarction, Middle Cerebral Artery', 'Intracranial Arteriosclerosis', 'Magnetic Resonance Angiography', 'Male', 'Middle Aged', 'Neurologic Examination', 'Prognosis', 'Recurrenc... | 25,177,953 | [['M01.060.116.100'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['A07.015.114.186'], ['C10.228.140.300.510.200', 'C14.907.253.560.200'], ['C23.300.287'], ['C14.907.355.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.228.140.300.150.477.200.450', 'C10.228.140.300.510.200.387', 'C10... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Effects of polyactin A on in vitro IL-2 production and responsiveness of human lymphocytes]. | The effects of a novel antitumor antibiotic polyactin A (PA) on in vitro IL-2 production and IL-2 responsiveness of human lymphocytes were investigated. The results show that PA in a concentration range from 0.01 to 100 micrograms/ml obviously augmented in vitro IL-2 production, IL-2 receptor expression and responsiven... | ['Antibiotics, Antineoplastic', 'Glycopeptides', 'Humans', 'Interleukin-2', 'Lymphocytes'] | 2,284,949 | [['D27.505.954.248.106'], ['D09.400.420', 'D12.644.233'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.465.021', 'D12.644.276.374.480.372', 'D12.776.467.374.465.021', 'D12.776.467.374.480.372', 'D23.529.374.465.155', 'D23.529.374.480.372'], ['A11.118.637.555.567', 'A15.145.229.637.555.567', 'A15.3... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Fluoride is not an activator of the smaller (20-25 kDa) GTP-binding proteins. | Effects of aluminum, magnesium, and fluoride (AMF) on members of both the trimeric G protein and smaller (20-25 kDa) monomeric GTP-binding protein families were examined. The dissociation of GDP from G proteins was blocked by AMF but was unchanged with the addition of AMF to any of six of the monomeric GTP-binding prot... | ['Adenosine Diphosphate Ribose', 'Aluminum', 'Animals', 'Brain', 'Catalysis', 'Cattle', 'Fluorides', 'GTP-Binding Proteins', 'Magnesium', 'Molecular Weight'] | 1,908,456 | [['D03.633.100.759.646.138.124.070.125', 'D09.408.620.569.070.125', 'D13.695.667.138.124.070.125', 'D13.695.827.068.124.070.125', 'D13.695.827.708.070.125'], ['D01.268.557.050', 'D01.552.547.050'], ['B01.050'], ['A08.186.211'], ['G02.130'], ['B01.050.150.900.649.313.500.380.271'], ['D01.248.497.158.380', 'D01.303.350.3... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bacterial phagocytosis in obstructive jaundice. A microbiologic and electron microscopic analysis. | Reticuloendothelial system dysfunction has been suggested as an explanation for the increased susceptibility to infection in patients with obstructive jaundice. In the present study, the response of cholestatic rats to a bacterial challenge was investigated and the uptake of bacteria by their Kupffer cells was examined... | ['Animals', 'Cholestasis', 'Female', 'Kupffer Cells', 'Liver', 'Lung', 'Phagocytosis', 'Rats', 'Rats, Inbred Strains', 'Sepsis', 'Staphylococcal Infections'] | 1,992,871 | [['B01.050'], ['C06.130.120.135'], ['A11.329.372.588', 'A11.627.482.588', 'A11.733.397.588', 'A15.382.670.522.588', 'A15.382.680.397.588'], ['A03.620'], ['A04.411'], ['G04.417.350', 'G09.188.665', 'G12.450.564.809', 'G12.688'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760', 'B01.050.150.900.64... | ['Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Validation of the Hearing Handicap Inventory for Adults Scale for Spanish-Speaking Patients. | OBJECTIVE: To perform translation, cross-cultural adaptation, and validation of the hearing handicap inventory for adults scale (HHIA) to the Spanish language.STUDY DESIGN: Prospective study.SETTING: Tertiary neurotologic referral center.PATIENTS: The study included 104 hearing impaired persons. Inclusion criteria were... | ['Adult', 'Female', 'Hearing Loss', 'Humans', 'Language', 'Male', 'Middle Aged', 'Prospective Studies', 'Psychometrics', 'Reproducibility of Results', 'Surveys and Questionnaires', 'Translating'] | 31,725,590 | [['M01.060.116'], ['C09.218.458.341', 'C10.597.751.418.341', 'C23.888.592.763.393.341'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.209.399', 'L01.559'], ['M01.060.116.630'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['F04.711.780'], ['E05.318.370.725', '... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
A multicenter disease management program for hospitalized patients with heart failure. | BACKGROUND: Despite the availability of proven therapies, outcomes in patients with heart failure (HF) remain poor. In this 2-stage, multicenter trial, we evaluated the effect of a disease management program on clinical and economic outcomes in patients with HF.METHODS AND RESULTS: In Stage 1, a pharmacist or nurse ass... | ['Aged', 'Aged, 80 and over', 'Angiotensin-Converting Enzyme Inhibitors', 'Canada', 'Counseling', 'Disease Management', 'Female', 'Heart Failure', 'Hospitalization', 'Humans', 'Inpatients', 'Male', 'Middle Aged', 'Patient Care Team', 'Patient Compliance', 'Patient Education as Topic'] | 15,599,837 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.519.389.745.085'], ['Z01.107.567.176'], ['F02.784.176', 'F04.408.413', 'N02.421.143.303', 'N02.421.461.363'], ['N04.590.607'], ['C14.280.434'], ['E02.760.400', 'N02.421.585.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.643.470'], ['M01.060.116.630... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Propranolol in yawning prophylaxis: a case report. | OBJECTIVE: Yawning is a frequent behavior with circadian effects. Sometimes, its frequency is very high and it is disturbing. However, there is no evidence-based treatment for yawning.METHOD: This is a case report of a man with severe yawning from about 2 years ago.RESULTS: Yawning reduced after taking propranolol.CONC... | ['Humans', 'Male', 'Middle Aged', 'Propranolol', 'Treatment Outcome', 'Yawning'] | 22,055,334 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['D02.033.100.624.698.711', 'D02.033.755.624.698.711', 'D02.092.063.624.698.711', 'D02.455.426.559.847.638.945', 'D04.615.638.945'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800'], ['G09.772.982']] | ['Organisms [B]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Psychosomatic aspects of children's consultations in primary care. | Family doctors identified psychological factors associated with the presenting complaint in 17% of children aged 7 to 12 years attending their care. When compared with other children attending within the same age group, children said by their doctors to show associated psychological factors tended to present with psych... | ['Child', 'Family', 'Family Health', 'Female', 'Humans', 'Male', 'Parent-Child Relations', 'Primary Health Care', 'Psychophysiologic Disorders', 'Referral and Consultation'] | 3,653,154 | [['M01.060.406'], ['F01.829.263', 'I01.880.853.150'], ['N01.400.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.263.370.290'], ['N04.590.233.727'], ['C23.888.592.700'], ['N04.452.758.849']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
News media coverage of direct-to-consumer pharmaceutical advertising: implications for countervailing powers theory. | Since a 1997 regulatory shift on the part of the US Food and Drug Administration (FDA), there has been an explosion of televised direct-to-consumer (DTC) pharmaceutical advertising in the United States. The introduction and growth of this form of advertising, as well as other recent evolutions in the health care arena,... | ['Advertising', 'Attitude of Health Personnel', 'Attitude to Health', 'Consumer Behavior', 'Drug Industry', 'Drug Prescriptions', 'Health Personnel', 'Humans', 'Mass Media', 'Sociology, Medical', 'United States'] | 18,073,249 | [['J01.219.687.274', 'L01.143.050'], ['F01.100.050', 'N05.300.100'], ['F01.100.150', 'N05.300.150'], ['F01.145.236'], ['J01.576.655.750'], ['E02.319.307', 'N02.421.668.778.500'], ['M01.526.485', 'N02.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.178.590'], ['F04.096.879.757.400', 'H02.790', 'I01.880.859... | ['Technology, Industry, and Agriculture [J]', 'Information Science [L]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phe... | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
[Absence of the palmar c triradius. Dermatoglyphic and geneologic study of a genetic character transmitted since the 17th century in a Quebec family]. | A dermatoglyphic research on the absence of the palmar c-triradius was carried out in a Canadian family line originating from a French married couple who settled in the Quebec City area in 1649. Of the 51 individuals examined, 34 showed that c-triradius was missing on one or both palms. The study of the family tree and... | ['Chromosome Aberrations', 'Chromosome Disorders', 'Dermatoglyphics', 'Female', 'Fingers', 'Foot', 'France', 'Hand', 'Humans', 'Male', 'Pedigree', 'Phenotype', 'Quebec', 'Radiography', 'Sex Chromosomes', 'Sex Factors', 'Time Factors'] | 6,606,380 | [['C23.550.210', 'G05.365.590.175'], ['C16.131.260', 'C16.320.180'], ['E05.318.740.225.500.375', 'I01.198.780.937.343', 'N04.452.910.099.500'], ['A01.378.800.667.430'], ['A01.378.610.250'], ['Z01.542.286'], ['A01.378.800.667'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.393.673'], ['G05.695'], ['Z01.107.567... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Anatomy [A]', 'Geographicals [Z]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
The effect of aglycosylation on the binding of mouse IgG to staphylococcal protein A. | Aglycosylated IgG produced by hybridoma cells cultured in the presence of tunicamycin was compared with normal IgG for its ability to bind to staphylococcal protein A. No differences were found in binding or elution profiles. It is concluded that aglycosylation does not produce major structural alterations at the CH2-C... | ['Animals', 'Electrophoresis, Polyacrylamide Gel', 'Hybridomas', 'Immunoglobulin G', 'Mice', 'Staphylococcal Protein A', 'Tunicamycin'] | 6,653,789 | [['B01.050'], ['E05.196.401.402', 'E05.301.300.319'], ['A11.251.353.485', 'A11.251.600.485'], ['D12.776.124.486.485.114.619.393', 'D12.776.124.790.651.114.619.393', 'D12.776.377.715.548.114.619.393'], ['B01.050.150.900.649.313.992.635.505.500'], ['D12.776.097.820', 'D23.050.161.821'], ['D03.383.742.680.725', 'D13.570.6... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The reliability of the histological diagnosis of endometritis in asymptomatic IVF cases: a multicenter observer study. | BACKGROUND: Chronic endometritis is associated with abnormal uterine bleeding, recurrent abortion and infertility. It is a subtle condition, and therefore is difficult to diagnose. The diagnosis is ultimately based on the presence of plasma cells in the endometrial stroma on histopathological examination. Literature on... | ['Adult', 'Biopsy', 'Chronic Disease', 'Endometritis', 'Endometrium', 'Female', 'Fertilization in Vitro', 'Gynecology', 'Humans', 'Hysteroscopy', 'Immunohistochemistry', 'Observer Variation', 'Pathology', 'Prevalence', 'Reproducibility of Results'] | 22,025,228 | [['M01.060.116'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['C23.550.291.500'], ['C13.351.500.056.750.249', 'C13.351.500.852.299'], ['A05.360.319.679.490'], ['E02.875.800.750', 'E05.820.800.750'], ['H02.403.763.750', '... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Association of vital exhaustion and depressive symptoms with changes in fibrin D-dimer to acute psychosocial stress. | OBJECTIVE: Vital exhaustion and depression are psychosocial risk factors of coronary artery disease. A hypercoagulable state in response to acute psychosocial stress contributes to atherothrombotic events. We aimed to investigate the hypothesis that vital exhaustion and depression correlate with stress-induced changes ... | ['Acute Disease', 'Antifibrinolytic Agents', 'Blood Coagulation', 'Cardiovascular Diseases', 'Depression', 'Fatigue', 'Female', 'Fibrin Fibrinogen Degradation Products', 'Humans', 'Male', 'Middle Aged', 'Stress, Psychological', 'Time Factors'] | 19,539,823 | [['C23.550.291.125'], ['D27.505.519.421.500', 'D27.505.954.502.270.463.091'], ['G09.188.390.150'], ['C14'], ['F01.145.126.350'], ['C23.888.369'], ['D12.776.124.270.300', 'D12.776.811.300.290'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['F01.145.126.990', 'F02.830.900'], ['G01.910.857']] | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Highly sensitive and rapid normal-phase chiral screen using high-performance liquid chromatography-atmospheric pressure ionization tandem mass spectrometry (HPLC/MS). | In the last years, there has been an increasing demand on the development of quantitative assays for determination of enantiopurity. Herein, we present a methodology based on a direct linking of an atmospheric pressure ionization mass spectrometer (MS-APCI) with a high-performance liquid chromatography HPLC (DAD) syste... | ['Atmospheric Pressure', 'Chromatography, High Pressure Liquid', 'Mass Spectrometry', 'Sensitivity and Specificity', 'Stereoisomerism'] | 15,560,479 | [['G16.500.750.274', 'N06.230.300.100.185'], ['E05.196.181.400.300'], ['E05.196.566'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700', 'N05.715.360.750.725', 'N06.850.520.445.800', 'N06.850.520.830.872'], ['G02.607.445.682']] | ['Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Heterogeneity of the supramammillary-hippocampal pathways: evidence for a unique GABAergic neurotransmitter phenotype and regional differences. | The supramammillary nucleus (SuM) provides substantial projections to the hippocampal formation. This hypothalamic structure is involved in the regulation of hippocampal theta rhythm and therefore the control of hippocampal-dependent cognitive functions as well as emotional behavior. A major goal of this study was to c... | ['Animals', 'Glutamic Acid', 'Hippocampus', 'Male', 'Mammillary Bodies', 'Neural Pathways', 'Neuroanatomical Tract-Tracing Techniques', 'Neurotransmitter Agents', 'Phenotype', 'Presynaptic Terminals', 'Rats', 'Rats, Sprague-Dawley', 'gamma-Aminobutyric Acid'] | 20,722,723 | [['B01.050'], ['D12.125.067.625.349', 'D12.125.119.409.349', 'D12.125.427.300'], ['A08.186.211.180.405', 'A08.186.211.200.885.287.500.345'], ['A08.186.211.180.497.362.500', 'A08.186.211.200.317.357.362.500'], ['A08.612'], ['E01.370.225.500.620.670.570', 'E01.370.225.750.600.670.570', 'E05.200.500.620.670.570', 'E05.200... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Study of the diurnal variation of human lymphocyte subsets. | The diurnal variation of peripheral white cells and in particular of different lymphocyte subsets has been investigated in 11 normal subjects. Monoclonal antibodies (Mab) phenotyping total T lymphocytes (UCHT1), cytotoxic/suppressor (UCHT4), helper T cells (Leu 3a), B lymphocytes (231) and K/NK cells (H25) have been us... | ['Adult', 'Antibodies, Monoclonal', 'Biometry', 'Circadian Rhythm', 'Humans', 'Leukocytes', 'Lymphocytes', 'Male', 'T-Lymphocytes, Helper-Inducer', 'T-Lymphocytes, Regulatory'] | 2,931,528 | [['M01.060.116'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['E05.318.740.225', 'N06.850.505.200'], ['G07.180.562.190'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.118.637', 'A15.145.229.637', 'A15.382.490'], ['A11.118.637.555.567', 'A15.145.229.637.555.5... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Mechanistic studies of tobacco carcinogenesis in mouse epidermis and lung tissues. | The particulate matter of tobacco smoke induces benign and malignant tumors in various animal tissues and species. The most widely used bioassay system for evaluating the carcinogenicity of tobacco tars is mouse skin. Mouse skin bioassays have led to the identification of the PAHs as the major tumor initiators, while s... | ['Animals', 'Animals, Newborn', 'Benzo(a)pyrene', 'Biological Assay', 'Carcinogenicity Tests', 'Carcinogens', 'Catechols', 'Cricetinae', 'DNA Damage', 'Epidermis', 'Humans', 'Lung', 'Mesocricetus', 'Mice', 'Risk Factors', 'Smoking'] | 2,748,687 | [['B01.050'], ['B01.050.050.282'], ['D02.455.426.559.847.799.306.300', 'D04.615.799.306.300'], ['E05.091'], ['E05.940.150'], ['D27.888.569.100'], ['D02.455.426.559.389.657.166'], ['B01.050.150.900.649.313.992.635.075.250'], ['G05.200'], ['A10.272.497', 'A17.815.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Health Care [N]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Positive and negative functions of the SAGA complex mediated through interaction of Spt8 with TBP and the N-terminal domain of TFIIA. | A surface that is required for rapid formation of preinitiation complexes (PICs) was identified on the N-terminal domain (NTD) of the RNA Pol II general transcription factor TFIIA. Site-specific photocross-linkers and tethered protein cleavage reagents positioned on the NTD of TFIIA and assembled in PICs identified the... | ['Amino Acid Sequence', 'Binding, Competitive', 'Cross-Linking Reagents', 'Hydroxyl Radical', 'Models, Biological', 'Molecular Sequence Data', 'Mutagenesis', 'Saccharomyces cerevisiae', 'Saccharomyces cerevisiae Proteins', 'Sequence Homology, Amino Acid', 'TATA-Box Binding Protein', 'Transcription Factor TFIIA', 'Trans... | 15,132,995 | [['G02.111.570.060', 'L01.453.245.667.060'], ['E05.196.080', 'G02.111.084', 'G02.111.570.120.309'], ['D27.720.470.410.210'], ['D01.045.250.357', 'D01.248.497.158.459.300', 'D01.339.431.249'], ['E05.599.395'], ['L01.453.245.667'], ['G05.558'], ['B01.300.107.795.785.800', 'B01.300.930.705.655'], ['D12.776.354.750'], ['G0... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Neuroprosthetic hearing with auditory brainstem implants. | The auditory brainstem implant (ABI) does provide auditory sensations, recognition of environmental sounds and aid in spoken communication in about 300 patients worldwide. It is no more an investigative device but widely accepted for the treatment of patients who have lost hearing due to bilateral tumors of the hearing... | ['Auditory Brain Stem Implants', 'Electric Stimulation Therapy', 'Equipment Failure Analysis', 'Hearing', 'Hearing Loss', 'Humans', 'Microelectrodes', 'Prosthesis Design', 'Signal Processing, Computer-Assisted', 'Therapy, Computer-Assisted'] | 15,171,587 | [['E07.305.250.319.381.500.249', 'E07.695.075', 'E07.695.202.381.500.249', 'E07.814.458.074'], ['E02.331', 'E02.779.468', 'E02.831.535.468'], ['E05.325.192'], ['F02.830.816.263', 'G07.888.500', 'G11.561.790.263'], ['C09.218.458.341', 'C10.597.751.418.341', 'C23.888.592.763.393.341'], ['B01.050.150.900.649.313.988.400.1... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Information Science [L]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Genome-wide gene-based analyses of weight loss interventions identify a potential role for NKX6.3 in metabolism. | Hundreds of genetic variants have been associated with Body Mass Index (BMI) through genome-wide association studies (GWAS) using observational cohorts. However, the genetic contribution to efficient weight loss in response to dietary intervention remains unknown. We perform a GWAS in two large low-caloric diet interve... | ['Adult', 'Animals', 'Bayes Theorem', 'Cohort Studies', 'Drosophila Proteins', 'Drosophila melanogaster', 'Female', 'Genome-Wide Association Study', 'Homeodomain Proteins', 'Humans', 'Male', 'Middle Aged', 'Polymorphism, Single Nucleotide', 'Risk Factors', 'Transcription Factors', 'Triglycerides', 'Weight Loss'] | 30,710,084 | [['M01.060.116'], ['B01.050'], ['E05.318.740.600.200', 'N05.715.360.750.625.150', 'N06.850.520.830.600.200'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['D12.776.093.500.462'], ['B01.050.500.131.617.720.500.500.750.310.250.500'], ['E05.318.370.392', 'E05.318.416.249', 'E05.393.385.5... | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Arterial hypertension and the right heart. A hemodynamic and echocardiographic study]. | OBJECTIVE: To evaluate the effects of arterial hypertension on the pulmonary circulation and the right heart.SETTING: Coronary Care Unit (UTIC Ars?nio Cordeiro) Hemodynamics Laboratory and Medicine I Echocardiography Laboratory-Santa Maria Hospital.PARTICIPANTS: 38 hypertensive patients separated in two groups: 24 with... | ['Adult', 'Aged', 'Blood Pressure', 'Cardiomegaly', 'Diastole', 'Echocardiography', 'Female', 'Follow-Up Studies', 'Humans', 'Hypertension', 'Male', 'Microcirculation', 'Middle Aged', 'Systole', 'Ventricular Function, Right'] | 1,838,483 | [['M01.060.116'], ['M01.060.116.100'], ['E01.370.600.875.249', 'G09.330.380.076'], ['C14.280.195', 'C23.300.775.250'], ['G09.330.580.295', 'G11.427.494.554.250', 'G11.427.494.570.295'], ['E01.370.350.130.750', 'E01.370.350.850.220', 'E01.370.370.380.220'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Comparative study of the abundance of various bacterial morphotypes in an eutrophic freshwater environment determined by AODC and TEM. | Transmission electron microscopy (TEM) and epifluorescence microscopy were used to obtain comparative measurements of total bacterial counts, and to enumerate abundances of various bacterial morphotypes in an eutrophic freshwater habitat. Although particulate matter would have been expected to interfere with counting b... | ['Acridine Orange', 'Bacteria', 'Bacteriological Techniques', 'Colony Count, Microbial', 'Fresh Water', 'Microscopy, Electron', 'Microscopy, Fluorescence', 'Water Microbiology'] | 10,670,768 | [['D03.633.300.046.250.150'], ['B03'], ['E01.370.225.875.150', 'E05.200.875.150'], ['E01.370.225.875.220', 'E05.200.875.220'], ['G16.500.275.280', 'N06.230.232'], ['E01.370.350.515.402', 'E05.595.402'], ['E01.370.350.515.458', 'E05.595.458'], ['H01.158.273.540.274.777', 'N06.850.425.450']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Release of plasma atrial natriuretic peptide after volume expansion is not related to pituitary-adrenal axis diurnal variation in normal subjects. | The existence of a circadian rhythm of atrial natriuretic peptide (ANP) in humans is controversial. We studied the plasma ANP response to isotonic blood volume expansion in the morning and in the afternoon and its relationship with adrenocorticotropic hormone (ACTH)-cortisol diurnal variation in seven normal subjects. ... | ['Adrenal Glands', 'Adrenocorticotropic Hormone', 'Adult', 'Atrial Natriuretic Factor', 'Circadian Rhythm', 'Female', 'Humans', 'Hydrocortisone', 'Male', 'Pituitary Gland', 'Plasma Substitutes'] | 9,283,629 | [['A06.300.071'], ['D06.472.699.327.935.531.500', 'D06.472.699.631.525.600.531.500', 'D12.644.400.400.935.531.500', 'D12.644.548.365.935.531.500', 'D12.644.548.691.525.690.531.500', 'D12.776.631.650.405.935.531.500'], ['M01.060.116'], ['D06.472.699.584.500', 'D12.644.548.585.500'], ['G07.180.562.190'], ['B01.050.150.90... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Comparison of overhead and cross-table lateral views for detection of knee-joint effusion. | Prompted by the failure to detect a clinically evident knee-joint effusion on the cross-table lateral view of an injured patient, a prospective study was carried out to compare the routine overhead and cross-table lateral knee views for detection of joint effusion in 18 patients with acute knee trauma. In every case, t... | ['Adult', 'Bursa, Synovial', 'Exudates and Transudates', 'Follow-Up Studies', 'Humans', 'Knee Injuries', 'Knee Joint', 'Male', 'Patella', 'Posture', 'Technology, Radiologic', 'Tomography, X-Ray Computed'] | 3,872,582 | [['M01.060.116'], ['A02.835.583.156'], ['A12.383'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C26.558.554'], ['A02.835.583.475'], ['A02.835.232.043.650.624', 'A02.835.232.730.500'], ['G11.427.695'], ['E05.920', 'H02.010.... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 |
Fetal Dysmorphology-Still an Essential Art. Analysis of the Limitations of Microarray in a Fetal Population and a Look Toward the Genome Sequencing Era. | Cytogenomic microarray allows assessment of the genome at higher resolutions than traditional karyotyping. The objective of this study is to evaluate the utility of microarray in a routine fetal autopsy setting before the advent of routine fetal exome/genome sequencing and the issues these technologies may generate. A ... | ['Autopsy', 'Congenital Abnormalities', 'Female', 'Fetal Death', 'Humans', 'Male', 'Real-Time Polymerase Chain Reaction', 'Retrospective Studies', 'Tissue Array Analysis'] | 28,727,969 | [['E01.370.060', 'E05.070', 'I01.198.780.937.120'], ['C16.131'], ['C13.703.223', 'C23.550.260.585'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.393.620.500.706'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.520.450.500.500.500... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Combined treatment of stage IV melanoma patients with amifostine and fotemustine--a pilot study. | Amifostine (Ethyol) is a new chemoprotective agent that has been shown to have significant activity in the prevention of nephro-, oto-, neuro- and haemotoxicity. In preclinical models as well as in clinical trials carried out in patients suffering from various malignancies, the adverse effects and signs of toxicity rel... | ['Amifostine', 'Antineoplastic Agents', 'Antineoplastic Combined Chemotherapy Protocols', 'Bone Marrow', 'Brain Neoplasms', 'Drug Administration Schedule', 'Humans', 'Leukopenia', 'Melanoma', 'Neoplasm Staging', 'Nitrosourea Compounds', 'Organophosphorus Compounds', 'Pilot Projects', 'Skin Neoplasms', 'Thrombocytopenia... | 9,610,871 | [['D02.705.400.625.050', 'D02.705.539.345.050', 'D02.886.300.692.050'], ['D27.505.954.248'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['A15.382.216'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['E02.319.283'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C15.378.553.546'], [... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Age-specific prevalence of diagnosed systemic lupus erythematosus in Germany 2002 and projection to 2030. | OBJECTIVE: The objective of this report is to estimate the prevalence and future number of cases of systemic lupus erythematosus (SLE) in Germany.METHODS: Data from a representative sample of all insurants from the statutory health insurance in Germany comprising more than 2.3 million individuals have been screened for... | ['Adolescent', 'Adult', 'Age Factors', 'Aged', 'Aged, 80 and over', 'Child', 'Child, Preschool', 'Female', 'Forecasting', 'Germany', 'Humans', 'Infant', 'Infant, Newborn', 'Insurance, Health', 'Lupus Erythematosus, Systemic', 'Male', 'Middle Aged', 'Prevalence', 'Sex Factors', 'Young Adult'] | 24,928,831 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['M01.060.406'], ['M01.060.406.448'], ['I01.320'], ['Z01.542.315'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['N03.219.521.576.343'], ['C17.300.480', 'C2... | ['Named Groups [M]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Patterns and persistence of larval retention and connectivity in a marine fish metapopulation. | Connectivity, the demographic linking of local populations through the dispersal of individuals, is one of the most poorly understood processes in population dynamics, yet has profound implications for conservation and harvest strategies. For marine species with pelagic larvae, direct estimation of connectivity remains... | ['Animal Distribution', 'Animals', 'Coral Reefs', 'Genetics, Population', 'Genotype', 'Larva', 'Microsatellite Repeats', 'Papua New Guinea', 'Perciformes', 'Population Dynamics', 'Seasons', 'Sequence Analysis, DNA', 'Water Movements'] | 22,891,716 | [['F01.145.113.069', 'G16.049'], ['B01.050'], ['G16.500.275.157.130', 'N06.230.124.130'], ['H01.158.273.343.335'], ['G05.380'], ['B05.500.500', 'G07.345.500.550.500.500'], ['G02.111.570.080.708.800.500', 'G05.360.080.708.800.500', 'G05.360.340.024.850.500'], ['Z01.639.760.590.715'], ['B01.050.150.900.493.602'], ['I01.2... | ['Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 |
Asymptomatic red lesion in anterior floor of mouth: diagnosis and management. | We have presented a case illustrating that an asymptomatic, red lesion in the oral mucosa should be considered a malignant neoplasm, until proved otherwise. A biopsy and microscopic examination of such lesions are necessary to establish a definitive diagnosis. An appropriate method of obtaining a tissue specimen from t... | ['Aged', 'Carcinoma, Squamous Cell', 'Color', 'Diagnosis, Differential', 'Humans', 'Male', 'Mouth Floor', 'Mouth Neoplasms'] | 6,960,077 | [['M01.060.116.100'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['G01.590.540.199'], ['E01.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A14.549.441'], ['C04.588.443.591', 'C07.465.530']] | ['Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Stakeholder engagement and public policy evaluation: factors contributing to the development and implementation of a regional network for geriatric care. | The development and implementation of a regional network that provides universally accessible and consistent services to the frail elderly living in Southwestern Ontario is described. Through continuous stakeholder engagement, clear network goals were identified and operationalized. Stakeholder commitment to the integr... | ['Aged', 'Diffusion of Innovation', 'Frail Elderly', 'Geriatric Nursing', 'Humans', 'National Health Programs', 'Ontario', 'Organizational Case Studies', 'Policy Making', 'Public Policy', 'Regional Health Planning'] | 18,399,264 | [['M01.060.116.100'], ['L01.143.320'], ['M01.060.116.100.540'], ['H02.478.676.236', 'N02.421.533.245'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.349.550'], ['Z01.107.567.176.639'], ['N03.349.380.710', 'N05.715.360.455'], ['N03.706.742'], ['I01.655.500.608', 'I01.880.604.825.608', 'N03.623.500.608'], ['N03... | ['Named Groups [M]', 'Information Science [L]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
Repair of potentially lethal damage in unfed plateau phase cultures of Ehrlich ascites tumour cells. I. Suspension cultures. | Plateau phase EAT-cells have been irradiated at different times in the plateau phase and their ability to repair PLD has been measured. A large capacity to repair PLD has been observed if the cultures are kept in the plateau phase for some hours after irradiation before diluting and plating to measure the survival. In ... | ['Animals', 'Carcinoma, Ehrlich Tumor', 'Cell Line', 'Cell Survival', 'DNA Repair', 'DNA, Neoplasm', 'Dose-Response Relationship, Radiation', 'Interphase', 'Mitosis', 'Time Factors', 'X-Rays'] | 6,968,721 | [['B01.050'], ['C04.557.470.200.200', 'C04.619.169'], ['A11.251.210'], ['G04.346'], ['G02.111.222', 'G05.219'], ['D13.444.308.425'], ['E05.799.513.500', 'G01.750.740.500', 'G04.712.500', 'G07.225', 'G07.738.500', 'N06.850.810.250.180'], ['G04.144.500'], ['G04.144.220.220.781', 'G05.113.220.781'], ['G01.910.857'], ['G01... | ['Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[A case of multilocular renal cyst showing neoplastic features]. | A 45-year-old woman was hospitalized with complaint of upper right abdominal pain. By serial examination, it was difficult to distinguish renal cyst from renal cancer. But, because of the frequency of the attacks of upper abdominal pain, nephrectomy was undertaken. The tumor measured 5 X 5 X 3 cm, was distinct from nor... | ['Diagnosis, Differential', 'Female', 'Humans', 'Kidney Diseases, Cystic', 'Kidney Neoplasms', 'Middle Aged', 'Radiography'] | 4,032,766 | [['E01.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.777.419.403', 'C13.351.968.419.403'], ['C04.588.945.947.535', 'C12.758.820.750', 'C12.777.419.473', 'C13.351.937.820.535', 'C13.351.968.419.473'], ['M01.060.116.630'], ['E01.370.350.700']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Characteristics of the use of cold combination products among older ambulatory patients at the National Hospital Organization Tochigi Medical Center in Japan: a retrospective single-center observational study. | OBJECTIVE: This study aimed to determine the frequency and characteristics of prescriptions of cold combination products among older ambulatory patients. A retrospective observational study was conducted using electronic medical records. All patients aged 65 years or older who continued visiting internal medicine physi... | ['Acetaminophen', 'Aged', 'Aged, 80 and over', 'Ambulatory Care', 'Anti-Inflammatory Agents, Non-Steroidal', 'Antipyretics', 'Caffeine', 'Common Cold', 'Drug Combinations', 'Drug Prescriptions', 'Electronic Health Records', 'Female', 'Follow-Up Studies', 'Histamine H1 Antagonists', 'Hospitals', 'Humans', 'Japan', 'Male... | 29,221,489 | [['D02.065.199.092.040', 'D02.092.146.113.092.040'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E02.760.106', 'N02.421.585.106'], ['D27.505.696.663.850.014.040.500', 'D27.505.954.158.030', 'D27.505.954.329.030'], ['D27.505.696.068'], ['D03.132.960.175', 'D03.633.100.759.758.824.175'], ['C01.748.162', 'C01.925.782.... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Charge-altering releasable transporters (CARTs) for the delivery and release of mRNA in living animals. | Functional delivery of mRNA to tissues in the body is key to implementing fundamentally new and potentially transformative strategies for vaccination, protein replacement therapy, and genome editing, collectively affecting approaches for the prevention, detection, and treatment of disease. Broadly applicable tools for ... | ['Animals', 'Biocompatible Materials', 'Carbocyanines', 'Cell Line', 'Cell Line, Tumor', 'Cells, Cultured', 'Female', 'Gene Transfer Techniques', 'Green Fluorescent Proteins', 'Humans', 'Mesenchymal Stem Cells', 'Mice, Inbred BALB C', 'RNA, Messenger'] | 28,069,945 | [['B01.050'], ['D25.130', 'D27.720.102.130', 'J01.637.051.130'], ['D02.455.326.397.300'], ['A11.251.210'], ['A11.251.210.190', 'A11.251.860.180'], ['A11.251'], ['E05.393.350'], ['D12.776.532.265'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.329.830.500', 'A11.872.590.500'], ['B01.050.050.199.520.520.338', '... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Urinary estrone glucuronide, pregnanediol glucuronide and human chorionic gonadotrophin in threatened abortion. | Estimations of urinary estrone glucuronide, pregnanediol glucuronide and human chorionic gonadotrophin were carried out by ELISA to see their potential in predicting an abnormal outcome in cases with vaginal bleeding in early pregnancy. Reference values were set up with samples from women without bleeding in present or... | ['Abortion, Missed', 'Abortion, Threatened', 'Chorionic Gonadotropin', 'Enzyme-Linked Immunosorbent Assay', 'Estrone', 'Female', 'Humans', 'Pregnancy', 'Pregnanediol'] | 2,905,284 | [['C13.703.039.173'], ['C13.703.090'], ['D06.472.699.322.326', 'D06.472.699.649.367', 'D12.644.548.726.367', 'D12.776.780.400'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['D04.210.500.365.415.414', 'D04.210.500.578.502.497', 'D06.472.040.502.49... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Influence of Solution Chemistry and Soft Protein Coronas on the Interactions of Silver Nanoparticles with Model Biological Membranes. | The influence of solution chemistry and soft protein coronas on the interactions between citrate-coated silver nanoparticles (AgNPs) and model biological membranes was investigated by assembling supported lipid bilayers (SLBs) composed of zwitterionic 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) on silica crystal se... | ['Citric Acid', 'Humans', 'Hydrogen-Ion Concentration', 'Kinetics', 'Lipid Bilayers', 'Metal Nanoparticles', 'Models, Biological', 'Phosphatidylcholines', 'Protein Corona', 'Quartz Crystal Microbalance Techniques', 'Serum Albumin', 'Silicon Dioxide', 'Silver', 'Solutions', 'Surface Properties'] | 26,812,241 | [['D02.241.081.901.434.249'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.300'], ['G01.374.661', 'G02.111.490'], ['D10.570.510', 'J01.637.087.500.510'], ['J01.637.512.600.500'], ['E05.599.395'], ['D10.570.755.375.760.400.800'], ['D12.776.642'], ['E05.196.778', 'E05.978.673'], ['D12.776.034.841', 'D12.776.124... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
beta-Adrenoceptor hypersensitivity after stopping oxprenolol: discrepant findings not attributable to methodology. | Using isoprenaline and glyceryl trinitrate (GTN) induced tachycardia we have compared the rebound beta-adrenoceptor hypersensitivity on stopping slow-release and conventional oxprenolol in young normotensive subjects. Heart rate on standing with GTN rose after stopping slow-release and conventional oxprenolol to peak l... | ['Adult', 'Heart Rate', 'Humans', 'Male', 'Nitroglycerin', 'Oxprenolol', 'Receptors, Adrenergic, beta', 'Substance Withdrawal Syndrome'] | 6,318,786 | [['M01.060.116'], ['E01.370.600.875.500', 'G09.330.380.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.640.636'], ['D02.033.100.624.698.633', 'D02.033.755.624.698.633', 'D02.092.063.624.698.633'], ['D12.776.543.750.670.300.300.340', 'D12.776.543.750.695.150.300.340', 'D12.776.543.750.720.330.300.340'], ['... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Emotional self-efficacy and alexithymia may affect compliance, renal function and quality of life in kidney transplant recipients: results from a preliminary cross-sectional study. | UNLABELLED: Recent studies show that alexithymia may influence compliance and quality of life in different clinical situations. The aim of this study was to evaluate the associations between alexithymia or emotional self-efficacy and compliance, quality of life (QoL) and renal function in renal transplant patients.METH... | ['Affective Symptoms', 'Cross-Sectional Studies', 'Female', 'Follow-Up Studies', 'Humans', 'Immunosuppression', 'Kidney Transplantation', 'Male', 'Middle Aged', 'Patient Compliance', 'Psychiatric Status Rating Scales', 'Quality of Life', 'Self Efficacy', 'Self Report', 'Surveys and Questionnaires', 'Treatment Outcome'] | 25,680,476 | [['F01.145.126.100'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.095.465.425.450', 'E05.478.610'], ['E02.870.500', 'E04.936.450.485', 'E04... | ['Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
[LM, EM and immunohistochemical observations on 10 cases of atypical carcinoid of the lung]. | Twenty-two cases of neuroendocrine tumor comprising neurosecretory granules were identified ultrastructurally in 124 cases of resected pulmonary carcinoma. Among these, 10 cases of atypical carcinoid of the lung were examined by LM, EM and immunohistochemical staining for NSE. The diagnosis of atypical carcinoid is dif... | ['Carcinoid Tumor', 'Diagnosis, Differential', 'Humans', 'Immunohistochemistry', 'Lung Neoplasms', 'Microscopy, Electron'] | 2,279,307 | [['C04.557.465.625.650.200', 'C04.557.470.200.025.200', 'C04.557.580.625.650.200'], ['E01.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512', 'H01.158.201.344.512', 'H01.158... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Physicochemical properties of a methacrylate-based dental adhesive incorporated with epigallocatechin-3-gallate. | This study aimed to evaluate the influence of epigallocatechin-3-gallate (EGCG) incorporation on the physicochemical properties of a methacrylate-based dental adhesive. EGCG was added to Adper Easy One (3M-ESPE) except in control group, to obtain concentrations of 0.01% w/w and 0.1% w/w of EGCG-doped adhesives. For wat... | ['Bisphenol A-Glycidyl Methacrylate', 'Catechin', 'Dental Cements', 'Dental Stress Analysis', 'Hardness', 'In Vitro Techniques', 'Materials Testing', 'Methacrylates', 'Resin Cements', 'Spectroscopy, Fourier Transform Infrared', 'Surface Properties'] | 25,590,200 | [['D02.241.081.069.600.150', 'D02.455.426.559.389.657.100', 'D05.750.716.822.308.200', 'D25.339.816.500.200', 'D25.720.716.822.308.200', 'J01.637.051.339.816.500.200', 'J01.637.051.720.716.822.308.200'], ['D03.383.663.283.240.190', 'D03.383.663.283.266.450.206', 'D03.633.100.150.240.190', 'D03.633.100.150.266.450.206']... | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Relationship Between Polymorphisms in Methotrexate Pathway Genes and Outcome of Methotrexate Treatment in a Cohort of 119 Patients with Juvenile Idiopathic Arthritis. | OBJECTIVE: To identify clinical and pharmacogenetic determinants of efficacy and toxicity of methotrexate (MTX) in juvenile idiopathic arthritis (JIA) over time.METHODS: A cohort of 119 consecutive patients with JIA treated with MTX was reviewed. The Juvenile Arthritis Disease Activity Score including 71 joints was use... | ['AMP Deaminase', 'ATP Binding Cassette Transporter, Subfamily G, Member 2', 'Antirheumatic Agents', 'Arthritis, Juvenile', 'Child', 'Child, Preschool', 'Female', 'Ferredoxin-NADP Reductase', 'Genotype', 'Humans', 'Infant', 'Male', 'Methotrexate', 'Methylenetetrahydrofolate Dehydrogenase (NADP)', 'Methylenetetrahydrofo... | 28,572,465 | [['D08.811.277.151.653.060'], ['D12.776.157.530.100.228.500', 'D12.776.395.550.020.457.500', 'D12.776.543.550.192.457.500', 'D12.776.543.585.100.228.500'], ['D27.505.954.329'], ['C05.550.114.122', 'C05.799.056', 'C17.300.775.049', 'C20.111.198'], ['M01.060.406'], ['M01.060.406.448'], ['D08.811.682.667.076'], ['G05.380'... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Ensembles of Bayesian-regularized genetic neural networks for modeling of acetylcholinesterase inhibition by huprines. | Acetylcholinesterase inhibition was modeled for a set of huprines using ensembles of Bayesian-regularized Genetic Neural Networks. In the Bayesian-regularized Genetic Neural Network approach the Bayesian regularization avoids overfitted regressions and the genetic algorithm allows exploring a wide pool of three-dimensi... | ['Acetylcholinesterase', 'Algorithms', 'Alkaloids', 'Animals', 'Bayes Theorem', 'Cattle', 'Cholinesterase Inhibitors', 'Computer Simulation', 'Drug Design', 'Models, Biological', 'Molecular Structure', 'Neural Networks, Computer', 'Quantitative Structure-Activity Relationship', 'Sesquiterpenes', 'Tacrine'] | 17,105,484 | [['D08.811.277.352.100.170.176'], ['G17.035', 'L01.224.050'], ['D03.132'], ['B01.050'], ['E05.318.740.600.200', 'N05.715.360.750.625.150', 'N06.850.520.830.600.200'], ['B01.050.150.900.649.313.500.380.271'], ['D27.505.519.389.275', 'D27.505.519.625.120.300', 'D27.505.696.577.120.300'], ['L01.224.160'], ['E05.290.500', ... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Effects of bariatric surgery on pericardial ectopic fat depositions and cardiovascular function. | OBJECTIVE: Cardiac ectopic fat depositions are thought to play a role in the pathogenesis of cardiovascular disease (CVD), the main cause of death in patients with type 2 diabetes. Diet-induced weight loss results in a decrease in cardiac ectopic fat stores, however if this is the same for surgically induced weight los... | ['Adipose Tissue', 'Adolescent', 'Adult', 'Bariatric Surgery', 'Cardiovascular Physiological Phenomena', 'Choristoma', 'Diabetes Mellitus, Type 2', 'Female', 'Humans', 'Male', 'Middle Aged', 'Obesity, Morbid', 'Pericardium', 'Pulse Wave Analysis', 'Young Adult'] | 24,392,723 | [['A10.165.114'], ['M01.060.057'], ['M01.060.116'], ['E02.650.500.062', 'E04.062'], ['G09.330'], ['C23.300.250'], ['C18.452.394.750.149', 'C19.246.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C18.654.726.500.700', 'C23.888.144.699.500.500', 'E01.370.600.115.100.160.120.699.500.500', 'G... | ['Anatomy [A]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Massage therapy for stress management: implications for nursing practice. | Unresolved stress has been shown to have numerous adverse effects on the body. A review of the literature has revealed 2 major themes: (1) research that argues that massage has a direct relationship with positive health outcomes and (2) research that stresses that although there are little or no measurable physiologica... | ['Cost-Benefit Analysis', 'Education, Nursing, Continuing', 'Humans', 'Massage', 'Stress, Psychological'] | 20,664,464 | [['N03.219.151.125'], ['I02.358.212.450', 'I02.358.462.399'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.190.599.750.750', 'E02.779.867.880.750', 'E02.831.535.867.880.750'], ['F01.145.126.990', 'F02.830.900']] | ['Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Aprotinin in the management of coagulopathy associated with amniotic fluid embolus. | Amniotic fluid embolus, also known as anaphylactoid syndrome of pregnancy is a rare complication of pregnancy. When it occurs, the maternal mortality rate may be as high as 86%, and in survivors, the morbidity rate may be just as high. Hallmark clinical features include maternal cardiovascular collapse with disseminate... | ['Adult', 'Aprotinin', 'Blood Cell Count', 'Blood Coagulation Disorders', 'Blood Coagulation Tests', 'Crystalloid Solutions', 'Embolism, Amniotic Fluid', 'Female', 'Hemostatics', 'Humans', 'Isotonic Solutions', 'Plasma Substitutes', 'Pregnancy', 'Uterus'] | 16,715,609 | [['M01.060.116'], ['D12.776.083'], ['E01.370.225.500.195.107', 'E01.370.225.625.107', 'E05.200.500.195.107', 'E05.200.625.107', 'E05.242.195.107', 'G04.140.107', 'G09.188.105'], ['C15.378.100'], ['E01.370.225.625.115', 'E05.200.625.115'], ['D26.776.498.500'], ['C13.703.634.404', 'C14.583.404', 'C14.907.355.350.354'], [... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Behavioral and emotional functioning in children of adolescent mothers. | This study compared children of mothers in three age groups--15-17, 18-19, and 20-24 years--at the birth of their first child. Outcome measures were ratings of psychological functioning obtained at three time periods from multiple sources. Results, controlling for family structure and maternal education, indicate that ... | ['Adolescent', 'Adult', 'Child', 'Child Behavior', 'Child, Preschool', 'Educational Status', 'Female', 'Humans', 'Male', 'Maternal Age', 'Mothers', 'Pregnancy', 'Pregnancy Complications', 'Risk', 'Self Concept', 'Single Person'] | 6,507,595 | [['M01.060.057'], ['M01.060.116'], ['M01.060.406'], ['F01.145.179'], ['M01.060.406.448'], ['N01.824.196'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G08.686.560', 'N05.715.350.075.550', 'N06.850.490.250.550'], ['F01.829.263.500.320.200', 'I01.880.853.150.500.340.270', 'M01.620.630'], ['G08.686.784.769'], ['C13... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Towards sustained silencing of HER2/neu in cancer by epigenetic editing. | UNLABELLED: The human epidermal growth factor receptor-2 (HER2/neu/ERBB2) is overexpressed in several cancer types. Although therapies targeting the HER2/neu protein result in inhibition of cell proliferation, the anticancer effect might be further optimized by limiting HER2/neu expression at the DNA level. Towards thi... | ['Breast Neoplasms', 'Cell Line, Tumor', 'DNA-Binding Proteins', 'Down-Regulation', 'Epigenesis, Genetic', 'Female', 'Gene Expression Regulation, Neoplastic', 'Gene Silencing', 'HEK293 Cells', 'Histone Methyltransferases', 'Histone-Lysine N-Methyltransferase', 'Humans', 'MCF-7 Cells', 'Methylation', 'Ovarian Neoplasms'... | 23,814,024 | [['C04.588.180', 'C17.800.090.500'], ['A11.251.210.190', 'A11.251.860.180'], ['D12.776.260'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['G05.308.203'], ['G05.308.370'], ['G05.308.203.374'], ['A11.251.210.172.750', 'A11.436.334'], ['D08.811.913.555.500.800.200'], ['D08.811.913.555.500.800.200.500'], ['B01.050.... | ['Diseases [C]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Structure-Based Derivation of Protein Folding Intermediates and Energies from Optical Tweezers. | Optical tweezers (OTs) measure the force-dependent time-resolved extension of a single macromolecule tethered between two trapped beads. From this measurement, it is possible to determine the folding intermediates, energies, and kinetics of the macromolecule. Previous data analysis generally has used the extension as a... | ['Amino Acid Sequence', 'HIV Envelope Protein gp41', 'Molecular Sequence Data', 'Optical Tweezers', 'Protein Folding', 'SNARE Proteins', 'Thermodynamics'] | 26,789,767 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D12.776.543.512.500.330', 'D12.776.964.775.325.164.200', 'D12.776.964.775.562.500.200', 'D12.776.964.970.880.325.164.200', 'D12.776.964.970.880.910.330', 'D23.050.327.520.330'], ['L01.453.245.667'], ['E05.650'], ['G01.154.651', 'G02.111.688'], ['D12.776.543.512.249', 'D12.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Immunotherapy of tumor-bearing mice with chemically modified tumor membrane fractions of two syngeneic tumor cell lines. | The effects of chemical modification on the immunogenicity of plasma membrane fractions of virus-induced and chemically induced tumor cell lines were tested in syngeneic tumor-bearing mice. The immunotherapeutic effects were dependent on (1) the chemical nature of the modifying reagent, which also determines the molecu... | ['Animals', 'Avian Sarcoma Viruses', 'Cell Line', 'Cell Membrane', 'Cell Survival', 'Cell Transformation, Neoplastic', 'Immunotherapy', 'Mice', 'Mice, Inbred Strains', 'Sarcoma, Experimental', 'Transplantation, Isogeneic'] | 6,091,881 | [['B01.050'], ['B04.613.807.070.120', 'B04.820.650.070.120'], ['A11.251.210'], ['A11.284.149'], ['G04.346'], ['C04.697.098.500', 'C23.550.727.098.500'], ['E02.095.465.425'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520', 'B01.050.150.900.649.313.992.635.505.500.400'], ['C04.557.450.795.830', '... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Fate of renal allografts transplanted in patients with urinary diversion. | Fifty-five kidneys were transplanted into 50 patients with supravesical urinary diversion at 16 transplant centers between 1970 and 1991. Of the 32 males and 18 females, 40 were adults (> or = 18 years) and 10 were less than 18 years old at the time of first transplant. Mean follow-up was 7.8 years. At last follow-up, ... | ['Adult', 'Child', 'Creatinine', 'Female', 'Follow-Up Studies', 'Graft Rejection', 'Humans', 'Kidney Transplantation', 'Life Tables', 'Male', 'Retrospective Studies', 'Survival Analysis', 'Time Factors', 'Treatment Outcome', 'Urinary Diversion'] | 8,212,204 | [['M01.060.116'], ['M01.060.406'], ['D03.383.129.308.207'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['G12.875.545.328'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.870.500', 'E04.936.450.485', 'E04.950.774.400'], ['E05.318.308.985.475', 'E05.318.740.100.500... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Reduction of nerve growth factor level in the brain of genetically ataxic mice (weaver, reeler). | By a highly sensitive enzyme immunoassay we measured the level of nerve growth factor (NGF) in the cerebellum and cerebrum of the neurologically mutant mice, weaver, reeler and Purkinje cell degeneration (PCD). A significant decrease in NGF level was observed in both cerebellum and cerebrum of weaver and reeler mutants... | ['Animals', 'Ataxia', 'Brain Chemistry', 'Cerebellum', 'Female', 'Male', 'Mice', 'Mice, Neurologic Mutants', 'Nerve Growth Factors', 'Reference Values', 'Species Specificity'] | 2,265,716 | [['B01.050'], ['C10.597.350.090', 'C23.888.592.350.090'], ['G02.111.150', 'G03.185'], ['A08.186.211.132.810.428.200'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.150.900.649.313.992.635.505.500.550.480'], ['D12.644.276.860', 'D12.776.467.860', 'D12.776.631.600', 'D23.529.850'], ['E05.978.810'], ['G16.824']] | ['Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Inhibition of mitochondrial function induces an integrated stress response in oligodendroglia. | Maternal inheritance of a pathogenic point mutation within complex I of the mitochondrial genome causes Leber's hereditary optic neuropathy (LHON), resulting in the neurodegeneration and demyelination of the optic nerve. The integrated stress response (ISR), a signaling pathway that responds to various stresses by acti... | ['Activating Transcription Factor 4', 'Adenosine Triphosphate', 'Cell Line', 'Cell Line, Tumor', 'Cell Proliferation', 'Cell Respiration', 'Dose-Response Relationship, Drug', 'Electron Transport Complex I', 'Enzyme Activation', 'Humans', 'Mitochondria', 'Mitogen-Activated Protein Kinase 8', 'Oligodendroglia', 'Optic At... | 19,233,273 | [['D12.776.260.108.061.937', 'D12.776.930.127.061.937'], ['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['A11.251.210'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.161.750', 'G07.345.249.410.750'], ['G03.197', 'G04.270'], ['G07.690.773.875', 'G07.690.936.500'], ['D05.500.562.249', 'D0... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Synthesis of photoresponsive dual NIR two-photon absorptive [60]fullerene triads and tetrads. | Broadband nonlinear optical (NLO) organic nanostructures exhibiting both ultrafast photoresponse and a large cross-section of two-photon absorption throughout a wide NIR spectrum may make them suitable for use as nonlinear biophotonic materials. We report here the synthesis and characterization of two C₆₀-(antenna)(x) ... | ['Absorption', 'Fullerenes', 'Humans', 'Nanostructures', 'Photochemotherapy', 'Photons', 'Photosensitizing Agents'] | 23,941,881 | [['G01.015', 'G02.010', 'G03.015', 'G03.787.024', 'G07.690.725.015'], ['D01.268.150.250', 'J01.637.512.600.612.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['J01.637.512'], ['E02.186.500', 'E02.319.685', 'E02.774.722'], ['G01.249.705', 'G01.358.500.505.650.782', 'G01.590.540.782', 'G01.750.250.650.782', 'G01... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Engineered GH11 xylanases from Orpinomyces sp. PC-2 improve techno-functional properties of bread dough. | BACKGROUND: Endo-1,4-â-xylanases have marked hydrolytic activity towards arabinoxylans. Xylanases (xynA) produced by the anaerobic fungus Orpinomyces sp. strain PC-2 have been shown to be superior in specific activity, which strongly suggests their applicability in the bakery industry for the processing of whole-wheat ... | ['Biocatalysis', 'Bread', 'Endo-1,4-beta Xylanases', 'Flour', 'Food Handling', 'Fungal Proteins', 'Hydrogen-Ion Concentration', 'Hydrolysis', 'Neocallimastigales', 'Protein Engineering', 'Triticum', 'Xylans'] | 29,999,533 | [['G02.111.086', 'G02.130.500', 'G03.105'], ['G07.203.300.100', 'J02.500.100'], ['D08.811.277.450.950.249'], ['G07.203.300.484', 'J02.500.484'], ['J01.576.423.200'], ['D12.776.354'], ['G02.300'], ['G02.380'], ['B01.300.665.600'], ['E05.393.420.601'], ['B01.650.940.800.575.912.250.822.918'], ['D09.698.925']] | ['Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Long-term risks for kidney donors. | Previous studies have suggested that living kidney donors maintain long-term renal function and experience no increase in cardiovascular or all-cause mortality. However, most analyses have included control groups less healthy than the living donor population and have had relatively short follow-up periods. Here we comp... | ['Adult', 'Cardiovascular Diseases', 'Case-Control Studies', 'Cause of Death', 'Female', 'Follow-Up Studies', 'Humans', 'Kidney Failure, Chronic', 'Kidney Transplantation', 'Living Donors', 'Male', 'Middle Aged', 'Norway', 'Proportional Hazards Models', 'Tissue and Organ Harvesting'] | 24,284,516 | [['M01.060.116'], ['C14'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['E05.318.308.985.550.250', 'N01.224.935.698.100', 'N06.850.505.400.975.550.250', 'N06.850.520.308.985.550.250'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Steroid treatment of acute graft-versus | Patients with acute graft-versus-host disease (GvHD) grade I were randomized to an observation arm (n=85) or to a treatment arm (n=86) consisting of 6-methylprednisolone 1 mg/kg/day, after stratification for age and donor type. The primary end point was development of grade II-IV GvHD. The cumulative incidence of grade... | ['Acute Disease', 'Adolescent', 'Adult', 'Aged', 'Child', 'Child, Preschool', 'Disease Progression', 'Graft vs Host Disease', 'Hematopoietic Stem Cell Transplantation', 'Humans', 'Infant', 'Infant, Newborn', 'Methylprednisolone', 'Middle Aged', 'Prognosis', 'Steroids', 'Survival Analysis', 'Young Adult'] | 28,971,905 | [['C23.550.291.125'], ['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.406'], ['M01.060.406.448'], ['C23.550.291.656'], ['C20.452'], ['E02.095.147.500.500.500', 'E04.936.225.687.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['D04.210.500.745.432.769.795.53... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Effects of trifluoperazine on the conformation and dynamics of membrane proteins in human erythrocytes. | The chemical modifications induced by trifluoperazine (TFP) in erythrocyte ghosts have been investigated by fluorescence quenching. The apparent distance separating the membrane protein tryptophans and bound 1-aniline-8-naphthalene sulfonate (ANS) molecules decreased after treating erythrocyte membranes with TFP. This ... | ['Anilino Naphthalenesulfonates', 'Dopamine Antagonists', 'Erythrocyte Membrane', 'Erythrocytes', 'Fluorescence', 'Fluorescent Dyes', 'Humans', 'Membrane Proteins', 'Protein Conformation', 'Trifluoperazine'] | 9,705,239 | [['D02.092.146.125', 'D02.455.426.559.847.638.555.282', 'D02.886.645.600.080.050.650.050', 'D04.615.638.555.282'], ['D27.505.519.625.150.175', 'D27.505.696.577.150.175'], ['A11.118.290.270', 'A11.284.149.356', 'A15.145.229.334.270'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['G01.358.500.505.650.665.500', 'G0... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Exfoliative cytology as a tool for monitoring pre-malignant and malignant lesions based on combined stains and morphometry techniques. | BACKGROUND: Prevention and early diagnosis have the greatest potential for public health and are the most effective method in the long-term to control oral cancer. The aim was to apply PAP staining together with AgNOR staining and morphometric analysis in oral exfoliative cytology, to determine the sensitivity and spec... | ['Adult', 'Aged', 'Aged, 80 and over', 'Antigens, Nuclear', 'Area Under Curve', 'Cell Nucleus', 'Coloring Agents', 'Cross-Sectional Studies', 'Cytodiagnosis', 'Cytoplasm', 'Early Detection of Cancer', 'Female', 'Humans', 'Leukoplakia, Oral', 'Lichen Planus, Oral', 'Male', 'Middle Aged', 'Mouth Neoplasms', 'Nucleolus Or... | 25,065,639 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D12.776.660.625', 'D23.050.290'], ['E05.318.740.200', 'G03.787.101', 'G07.690.725.064', 'N06.850.520.830.200'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['D27.720.233'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.8... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Methylation of SFRP5 is related to multidrug resistance in leukemia cells. | Methylation of secreted frizzle-related protein (SFRP) genes activates Wnt/?-catenin signaling and promotes tumor development. This study investigated whether SFRP5 gene methylation causes multidrug resistance (MDR) in leukemia through the Wnt/?-catenin signaling, leading to the upregulation of the mdr1 gene and its pr... | ['ATP Binding Cassette Transporter, Subfamily B', 'ATP Binding Cassette Transporter, Subfamily B, Member 1', 'Adaptor Proteins, Signal Transducing', 'Analysis of Variance', 'Blotting, Western', 'Cell Line, Tumor', 'DNA Methylation', 'Doxorubicin', 'Drug Resistance, Multiple', 'Eye Proteins', 'Gene Expression Regulation... | 24,434,572 | [['D12.776.157.530.100.075', 'D12.776.157.530.450.074.500.500.250', 'D12.776.395.550.020.400', 'D12.776.543.550.192.400', 'D12.776.543.585.100.200', 'D12.776.543.585.450.074.500.500.250'], ['D12.776.157.530.100.075.063', 'D12.776.157.530.450.074.500.500.250.125', 'D12.776.395.550.020.400.153', 'D12.776.543.550.192.400.... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
The impact of institutional case volume on the prognosis of ruptured aortic aneurysms: a Japanese nationwide study. | OBJECTIVES: To improve outcome for ruptured aortic aneurysms (rAAs), centralization of treatment is potentially effective. However, there is no nationwide survey for the current managements and outcomes of rAA in Japan. The aim of this study was to assess the volume-outcome relationship for rAA treatment using the nati... | ['Aged', 'Aged, 80 and over', 'Aortic Aneurysm, Abdominal', 'Aortic Rupture', 'Databases, Factual', 'Female', 'Hospital Mortality', 'Humans', 'Incidence', 'Japan', 'Male', 'Odds Ratio', 'Patient Discharge', 'Prognosis', 'Registries', 'Time Factors', 'Treatment Outcome'] | 30,789,211 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['C14.907.055.239.075', 'C14.907.109.139.075'], ['C14.907.055.185.125', 'C14.907.055.239.175', 'C14.907.109.139.175', 'C26.761.125'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['E05.318.308.985.550.400', 'N01.224.935.698.400', 'N06.850.505.400.975.550.400', 'N06.... | ['Named Groups [M]', 'Diseases [C]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
Procreative experiences and orientations toward paternity held by incarcerated adolescent males. | PURPOSE: To describe the procreative experiences and the attitudes related to paternity held by a sample of incarcerated adolescent males.METHODS: All adolescent males who were admitted to a long-term correctional facility between July 1994 and October 1994 were asked to participate in a confidential, face-to-face inte... | ['Adolescent', 'African Americans', 'Alabama', 'Attitude', 'Cross-Sectional Studies', 'European Continental Ancestry Group', 'Female', 'Humans', 'Interviews as Topic', 'Male', 'Paternity', 'Pregnancy', 'Pregnancy in Adolescence', 'Prisoners', 'Social Responsibility'] | 9,069,020 | [['M01.060.057'], ['M01.686.508.100.100', 'M01.686.754.100'], ['Z01.107.567.875.075.100', 'Z01.107.567.875.750.100'], ['F01.100'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['M01.686.508.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.420', 'L01.399.250.520', '... | ['Named Groups [M]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Information Science [L]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]', 'Humanities [K]... | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
Relationship between temperature, dopaminergic neurotoxicity, and plasma drug concentrations in methamphetamine-treated squirrel monkeys. | To examine the relationship between temperature (ambient and core), dopaminergic neurotoxicity, and plasma drug [methamphetamine (METH)] and metabolite [amphetamine (AMPH)] concentrations, two separate groups of squirrel monkeys (n = 4-5 per group) were treated with METH (1.25 mg/kg, given twice, 4 h apart) or vehicle ... | ['Animals', 'Body Temperature', 'Corpus Striatum', 'Female', 'Male', 'Methamphetamine', 'Saimiri'] | 16,293,712 | [['B01.050'], ['E01.370.600.875.374', 'G07.110'], ['A08.186.211.200.885.287.249.487'], ['D02.092.471.683.152.619'], ['B01.050.150.900.649.313.988.400.600.150.710.710']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cystic hamartoma of the liver. | A case of cystic hamartoma of the liver is reported. The clinical presentation and management is discussed. A review of the origin of this rare tumor and its clinical and pathological characteristics is made. | ['Female', 'Hamartoma', 'Humans', 'Liver Neoplasms', 'Middle Aged'] | 536,140 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Distribution of linear accelerators in Great Britain. Use of fast electrons and their main applications]. | The features of the electron beam that make it a unique therapeutic tool, are related to physical characteristic rather than to any special biological effectiveness. The advantages of the dose distribution pattern are greatest at low energies (under 20 MeV), suggesting the use of electrons for irradiation of superficia... | ['Electrons', 'Humans', 'Particle Accelerators', 'Radiotherapy', 'United Kingdom'] | 2,251,412 | [['G01.249.335', 'G01.358.500.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E07.710.680'], ['E02.815'], ['Z01.542.363']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Effects of head position on intraoral pressures in Class I and Class II adults. | Variations in resting lip and tongue pressures and their relationship to alterations in head posture were investigated in subjects with Class I and Class II dental and skeletal morphology. Intraoral pressures were measured by means of transducers mounted in plastic carriers, customized for each subject from dental cast... | ['Adolescent', 'Adult', 'Dental Occlusion', 'Female', 'Head', 'Humans', 'Lip', 'Male', 'Malocclusion', 'Malocclusion, Angle Class I', 'Malocclusion, Angle Class II', 'Pressure', 'Tongue', 'Transducers'] | 3,857,007 | [['M01.060.057'], ['M01.060.116'], ['E06.276', 'G10.549.208'], ['A01.456'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A01.456.505.631.515', 'A14.549.336'], ['C07.793.494'], ['C07.793.494.610'], ['C07.793.494.630'], ['G01.374.715'], ['A03.556.500.885', 'A14.549.885'], ['E07.305.812']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Exercise-induced improvements in glucose effectiveness are blunted by a high glycemic diet in adults with prediabetes. | AIMS: Glucose effectiveness (GE) refers to the ability of glucose to influence its own metabolism through insulin-independent mechanisms. Diminished GE is a predictor of progression to type 2 diabetes. Exercise training improves GE, however, little is known about how dietary interventions, such as manipulating the glyc... | ['Aged', 'Diabetes Mellitus, Type 2', 'Diet Therapy', 'Exercise Therapy', 'Female', 'Glucose', 'Glucose Tolerance Test', 'Glycemic Index', 'Humans', 'Insulin Resistance', 'Male', 'Middle Aged', 'Obesity', 'Prediabetic State', 'Treatment Outcome'] | 30,612,202 | [['M01.060.116.100'], ['C18.452.394.750.149', 'C19.246.300'], ['E02.642.249'], ['E02.760.169.063.500.387', 'E02.779.483', 'E02.831.535.483'], ['D09.947.875.359.448'], ['E01.370.225.124.100.355', 'E01.370.374.355', 'E05.200.124.100.355'], ['G07.203.650.660.500', 'J01.576.423.850.730.750.500', 'N06.850.601.750.500'], ['B... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Morphological and molecular characterization of healthy human ascending aorta. | Knowledge of the characteristics of the normal human aorta has been constrained by lack of data on fresh aortic tissue, especially from healthy individuals. In this study, the gene expression and morphological characteristics of the thoracic ascending aorta (AA) of healthy organ donors have been evaluated, with the aim... | ['Actins', 'Adult', 'Aorta, Thoracic', 'Cytoskeletal Proteins', 'Female', 'Fibronectins', 'Gene Expression Regulation', 'Humans', 'Immunohistochemistry', 'Male', 'Middle Aged', 'Muscle Proteins', 'Nuclear Proteins', 'RNA, Messenger', 'Reverse Transcriptase Polymerase Chain Reaction', 'Trans-Activators', 'Young Adult'] | 22,127,602 | [['D05.750.078.730.250', 'D12.776.210.500.100', 'D12.776.220.525.255'], ['M01.060.116'], ['A07.015.114.056.372'], ['D12.776.220'], ['D12.776.377.715.390', 'D12.776.395.550.350', 'D12.776.543.550.350', 'D12.776.860.300.450'], ['G05.308'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Observations on intravenous administration of lignocaine in patients with myocardial infarction. | Lignocaine was administered intravenously to 36 patients with acute myocardial infarction. A bolus of 100 mg followed by an infusion of 2 mg/minute failed to maintain plasma levels above 2 microgram/ml. A bolus of 100 mg followed by 4 mg/minute also failed to maintain satisfactory plasma concentrations during the first... | ['Arrhythmias, Cardiac', 'Female', 'Humans', 'Infusions, Parenteral', 'Lidocaine', 'Male', 'Middle Aged', 'Myocardial Infarction'] | 737,094 | [['C14.280.067', 'C23.550.073'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.267.510'], ['D02.065.199.092.500', 'D02.092.146.113.092.500'], ['M01.060.116.630'], ['C14.280.647.500', 'C14.907.585.500', 'C23.550.513.355.750', 'C23.550.717.489.750']] | ['Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
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