Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Population data of 23 Y STRs from Manchu population of Liaoning Province, Northeast China. | Mongol-like-horsemen-turned-merchants from Manchuria are known as Manchus, originally their homeland was centered around what is nowadays the city of Shenyang in Northeast China. Previously, worldwide analysis of Y-chromosomal haplotype diversity for 23 STR loci and Y-STR databases with PowerPlex® Y23 System (Promega C... | ['China', 'Chromosomes, Human, Y', 'DNA Fingerprinting', 'Ethnic Groups', 'Genetic Variation', 'Genetics, Population', 'Haplotypes', 'Humans', 'Male', 'Microsatellite Repeats', 'Polymerase Chain Reaction'] | 30,353,363 | [['Z01.252.474.164'], ['A11.284.187.520.300.505.757', 'A11.284.187.865.983.500', 'G05.360.162.520.300.505.757', 'G05.360.162.865.983.500'], ['E05.318.740.225.500.500', 'E05.393.290', 'I01.198.780.937.375', 'N04.452.910.099.750'], ['M01.686.754', 'N01.224.317'], ['G05.365'], ['H01.158.273.343.335'], ['G05.380.360'], ['B... | ['Geographicals [Z]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Named Groups [M]', 'Disciplines and Occupations [H]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Prevalence and severity of menstrual symptoms among institutionalised women with an intellectual disability. | BACKGROUND: Perimenstrual syndrome (PMS) among women with an intellectual disability (ID) has not been investigated in Taiwan. This study explores the prevalence/severity of PMS experienced by women with ID who are institutionalised.METHOD: Ninety two female residents aged 15 to 54 at six public institutions completed ... | ['Adolescent', 'Adult', 'Arousal', 'Female', 'Humans', 'Institutionalization', 'Intellectual Disability', 'Male', 'Menstruation', 'Middle Aged', 'Prevalence', 'Severity of Illness Index', 'Surveys and Questionnaires', 'Syndrome', 'Young Adult'] | 19,234,977 | [['M01.060.057'], ['M01.060.116'], ['F02.830.104', 'G11.561.035'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.760.415', 'N02.421.585.415'], ['C10.597.606.360', 'C23.888.592.604.646', 'F01.700.687', 'F03.625.539'], ['G08.686.605.428'], ['M01.060.116.630'], ['E05.318.308.985.525.750', 'N01.224.935.597.750', '... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The effect of beta-hydroxy-beta-methylbutyrate on growth, mortality, and carcass qualities of broiler chickens. | Experiments were conducted to determine whether the leucine catabolite beta-hydroxy-beta-methylbutyrate (HMB) could influence protein metabolism in broilers. In Experiment 1, HMB was fed at either .01 or .05% of the diet. beta-Hydroxy-beta-methylbutyrate did not improve feed conversion or BW gain; however, broilers fed... | ['Animal Feed', 'Animals', 'Bacitracin', 'Body Weight', 'Chickens', 'Female', 'Food, Fortified', 'Male', 'Monensin', 'Mortality', 'Random Allocation', 'Valerates'] | 8,165,160 | [['G07.203.300.300.100', 'J02.500.300.100'], ['B01.050'], ['D04.345.566.075', 'D12.644.641.075'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['G07.203.300.515', 'J02.500.515'], ['D03... | ['Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
A telehealth program for self-management of COPD exacerbations and promotion of an active lifestyle: a pilot randomized controlled trial. | The objective of this pilot study was to investigate the use of and satisfaction with a chronic obstructive pulmonary disease (COPD) telehealth program applied in both primary and secondary care. The program consisted of four modules: 1) activity coach for ambulant activity monitoring and real-time coaching of daily ac... | ['Aged', 'Counseling', 'Disease Progression', 'Exercise Tolerance', 'Female', 'Health Knowledge, Attitudes, Practice', 'Health Promotion', 'Humans', 'Internet', 'Lung', 'Male', 'Middle Aged', 'Motor Activity', 'Netherlands', 'Patient Compliance', 'Patient Education as Topic', 'Patient Satisfaction', 'Pilot Projects', '... | 25,246,781 | [['M01.060.116.100'], ['F02.784.176', 'F04.408.413', 'N02.421.143.303', 'N02.421.461.363'], ['C23.550.291.656'], ['G11.427.680.270'], ['F01.100.150.500', 'N05.300.150.410'], ['I02.233.332.445', 'N02.421.726.407.579'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.230.110.500'], ['A04.411'], ['M01.060.116.6... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Information Science [L]', 'Anatomy [A]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and ... | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
Effects of normothermic organ bath and verapamil-nitroglycerin solution alone or in combination on the blood flow of radial artery. | OBJECTIVE: Radial artery pedicle tissue cooling during harvesting is one of the major causes of vasospasm. We aimed to compare the effects of the pedicle rewarming method, normothermic organ bath, and one of the most preferred topical antispasmodic agents, verapamil-nitroglycerin solution alone or in combination on the... | ['Adult', 'Aged', 'Body Temperature', 'Drug Combinations', 'Female', 'Humans', 'Hypothermia, Induced', 'Male', 'Middle Aged', 'Nitroglycerin', 'Parasympatholytics', 'Prospective Studies', 'Radial Artery', 'Regional Blood Flow', 'Spasm', 'Tissue and Organ Harvesting', 'Vascular Diseases', 'Vasodilator Agents', 'Verapami... | 17,709,252 | [['M01.060.116'], ['M01.060.116.100'], ['E01.370.600.875.374', 'G07.110'], ['D26.310'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.258.750'], ['M01.060.116.630'], ['D02.640.636'], ['D27.505.696.663.050.650'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['A07.01... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Health Care [N]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Multidrug and carbapenem-resistant Acinetobacter baumannii infections: Factors associated with mortality. | BACKGROUND AND OBJECTIVE: To analyse factors related to mortality and influence of antibiotic treatment on outcome in patients with nosocomial infection due to multidrug and carbapenem-resistant Acinetobacter baumannii (MDR-C AB).PATIENTS AND METHODS: Observational and prospective study of a cohort of adult patients wi... | ['Acinetobacter Infections', 'Acinetobacter baumannii', 'Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Anti-Bacterial Agents', 'Bacteremia', 'Carbapenems', 'Cross Infection', 'Drug Resistance, Multiple, Bacterial', 'Female', 'Humans', 'Male', 'Middle Aged', 'Multivariate Analysis', 'Prospective Studies', 'Young A... | 22,093,403 | [['C01.150.252.400.560.022'], ['B03.440.400.425.537.050.099', 'B03.660.250.530.050.099'], ['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.954.122.085'], ['C01.150.252.100', 'C01.757.100', 'C23.550.470.790.500.100'], ['D02.065.589.099.124', 'D03.633.100.300.124'], ['C01.248', 'C... | ['Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Cancer control in Peru: a comprehensive approach to a public health issue]. | Cancer as a public health issue is changing and complex. It calls for a comprehensive, coherent and horizontal strategy based on previous experiences and considering the alarming increase of this condition worldwide. Therefore, it is imperative to reach and respect consensuses, to promote new technologies and study cul... | ['Humans', 'Incidence', 'Neoplasms', 'Peru', 'Public Health'] | 23,612,820 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.985.525.375'], ['C04'], ['Z01.107.757.702'], ['H02.403.720', 'N01.400.550', 'N06.850']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Geographicals [Z]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
Discovery of [3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo[2,3-b]pyridin-1-yl]acetic acids as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications. | Efforts to identify treatments for chronic diabetic complications have resulted in the discovery of a novel series of highly potent and selective [3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo[2,3-b]pyridin-1-yl]acetic acid aldose reductase inhibitors. The lead candidate, [6-methyl-3-(4,5,7-trifluoro-benzothiazol... | ['Acetates', 'Aldehyde Reductase', 'Benzothiazoles', 'Catalytic Domain', 'Chronic Disease', 'Computer Simulation', 'Crystallography, X-Ray', 'Diabetes Complications', 'Enzyme Inhibitors', 'Humans', 'Inhibitory Concentration 50'] | 19,250,825 | [['D02.241.081.018', 'D10.251.400.045'], ['D08.811.682.047.150.700.156.500', 'D08.811.682.047.820.284.500'], ['D03.383.129.708.089', 'D03.633.100.185'], ['G02.111.570.120.704', 'G02.111.570.820.709.275.750.188'], ['C23.550.291.500'], ['L01.224.160'], ['E05.196.309.742.225'], ['C19.246.099'], ['D27.505.519.389'], ['B01.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Isolation, characterization, and identification of Geobacillus thermodenitrificans HRO10, an alpha-amylase and alpha-glucosidase producing thermophile. | Thermophilic and amylolytic aerobic bacteria were isolated from soil through a selective enrichment procedure at 60 degrees C with starch as the carbon source. One of the isolates designated as HRO10 produced glucose aside from limit dextrin as the only hydrolysis product from starch and was characterized in detail. Th... | ['Bacillaceae', 'DNA, Bacterial', 'Hot Temperature', 'RNA, Ribosomal, 16S', 'Sequence Analysis, DNA', 'Soil Microbiology', 'Starch', 'alpha-Amylases', 'alpha-Glucosidases'] | 16,234,866 | [['B03.300.390.400.158', 'B03.353.500.100', 'B03.510.100.100', 'B03.510.415.400.158', 'B03.510.460.410.158'], ['D13.444.308.212'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.775.710.380', 'N06.230.300.100.725.232', 'N06.230.300.100.725.710.380'], ['D13.444.735.686.670'], ['E05.393.760.700'], ['H01.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
[Increased thrombin time in a patient with multiple myeloma]. | We describe a 56-year-old patient with multiple myeloma and very high paraprotein concentration (IgG kappa). Coagulation studies showed unclottable thrombin and reptilase times caused by impaired fibrin polymerization presumably due to the paraproteinemia. There was no obvious bleeding tendency. The differential diagno... | ['Diagnosis, Differential', 'Fibrin', 'Hemorrhagic Disorders', 'Humans', 'Immunoglobulin kappa-Chains', 'Male', 'Middle Aged', 'Multiple Myeloma', 'Thrombin Time'] | 10,517,116 | [['E01.171'], ['D12.776.124.270'], ['C15.378.463'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.124.486.485.705.750.530', 'D12.776.124.790.651.705.750.530', 'D12.776.377.715.548.705.750.530'], ['M01.060.116.630'], ['C04.557.595.500', 'C14.907.454.460', 'C15.378.147.780.650', 'C15.378.463.515.460', 'C20.6... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Influence of heart rate on metabolic and hemodynamic parameters in the Syrian hamster cardiomyopathy. | The effect of varying heart rate in 155- to 170-day-old isolated, perfused cardiomyopathic Syrian hamster hearts was evaluated by 31P nuclear magnetic resonance spectroscopy. At a low paced heart rate of 170 bpm, cardiomyopathic hearts did not differ from normal hearts except for a lower developed left ventricular pres... | ['Adenosine Triphosphate', 'Animals', 'Blood Pressure', 'Coronary Circulation', 'Cricetinae', 'Energy Metabolism', 'Heart Failure', 'Heart Rate', 'Magnetic Resonance Spectroscopy', 'Mesocricetus', 'Oxygen Consumption', 'Phosphorus'] | 3,604,893 | [['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['B01.050'], ['E01.370.600.875.249', 'G09.330.380.076'], ['G09.330.100.324'], ['B01.050.150.900.649.313.992.635.075.250'], ['G03.295'], ['C14.280.434'], ['E01.370.600.875.500', 'G09.330.380.500'], ['E05.196.867.519'], ['B01.050.150.900.649.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Utility of systematically determining serum HBsAg in the 3d trimester of pregnancy]. | A group of pregnant women living in the south of the province of Pontevedra (Spain) have been studied in order to determine the prevalence of hepatitis B virus biological markers. For that respect we have prospectively studied HBsAg and other markers in 535 pregnant women from June 1987 to March 1988. The prevalence of... | ['Adolescent', 'Adult', 'Female', 'Hepatitis B', 'Hepatitis B Surface Antigens', 'Humans', 'Middle Aged', 'Pregnancy', 'Pregnancy Complications, Infectious', 'Pregnancy Trimester, Third', 'Prospective Studies', 'Spain'] | 2,717,791 | [['M01.060.057'], ['M01.060.116'], ['C01.221.250.500', 'C01.925.256.430.400', 'C01.925.440.435', 'C06.552.380.705.437'], ['D23.050.327.495.500.475'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['G08.686.784.769'], ['C01.674', 'C13.703.700'], ['G08.686.707.520'], ['E05.318.372.500.750.625', 'N... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Phosphorylation of Janus kinase 1 (JAK1) by AMP-activated protein kinase (AMPK) links energy sensing to anti-inflammatory signaling. | Adenosine 5'-monophosphate-activated protein kinase (AMPK) is a pivotal regulator of metabolism at cellular and organismal levels. AMPK also suppresses inflammation. We found that pharmacological activation of AMPK rapidly inhibited the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway ... | ['14-3-3 Proteins', 'AMP-Activated Protein Kinases', 'Amino Acid Substitution', 'Animals', 'Endothelial Cells', 'Enzyme Activation', 'Janus Kinase 1', 'Mice', 'Mice, Knockout', 'Mutation, Missense', 'Phosphorylation', 'STAT3 Transcription Factor', 'Signal Transduction'] | 27,919,027 | [['D12.644.360.024.050', 'D12.776.157.057.002', 'D12.776.476.024.050'], ['D08.811.913.696.620.682.700.085', 'D12.644.360.062', 'D12.776.476.062'], ['E05.393.420.601.035', 'G05.558.109'], ['B01.050'], ['A11.436.275'], ['G02.111.263', 'G03.328'], ['D08.811.913.696.620.682.725.124.100', 'D12.776.476.393.100'], ['B01.050.1... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of serum from rabbits of various ages on cell proliferation. | The report of Carrel and Ebeling (J. Exp. Med., 34 (1921) 599-623) generally gives the impression that both serum and blood plasma from old animals inhibit cell proliferation. For confirmation of this, we examined the effects of serum from rabbits of various ages on rabbit fetal skin fibroblasts (RSF cell) and human fe... | ['Aging', 'Animals', 'Blood Physiological Phenomena', 'Cattle', 'Cell Division', 'Cell Line', 'Female', 'Fetus', 'Fibroblasts', 'Humans', 'Kinetics', 'Lung', 'Pregnancy', 'Rabbits', 'Skin', 'Species Specificity'] | 3,835,412 | [['G07.345.124'], ['B01.050'], ['G09.188'], ['B01.050.150.900.649.313.500.380.271'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.251.210'], ['A16.378'], ['A11.329.228'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.374.661', 'G02.111.490'], ['A04.411'], ['G08.686.784.769'],... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Lymphoma with bladder involvement and renal transplantation]. | Based on the case of a renal transplant recipient who developed a monoclonal B cell lymphoma with plasma cell differentiation, arising in the bladder, the authors discuss the responsibility of intensive immunosuppressant protocols in the development of post-transplantation lymphoproliferative syndromes. The Epstein-Bar... | ['Herpesviridae Infections', 'Herpesvirus 4, Human', 'Humans', 'Immunosuppressive Agents', 'Kidney Transplantation', 'Lymphoma, B-Cell', 'Lymphoma, Large B-Cell, Diffuse', 'Male', 'Middle Aged', 'Neoplasm Staging', 'Tumor Virus Infections', 'Urinary Bladder Neoplasms'] | 7,719,353 | [['C01.925.256.466'], ['B04.280.210.400.500.450', 'B04.280.382.400.500.400', 'B04.613.204.500.500.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.477.656'], ['E02.870.500', 'E04.936.450.485', 'E04.950.774.400'], ['C04.557.386.480.150', 'C15.604.515.569.480.150', 'C20.683.515.761.480.150'], ['C04.5... | ['Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
PDE4D promotes FAK-mediated cell invasion in BRAF-mutated melanoma. | The cyclic AMP (cAMP) signaling pathway is critical in melanocyte biology for regulating differentiation. It is downregulated by phosphodiesterase (PDE) enzymes, which degrade cAMP itself. In melanoma evidence suggests that inhibition of the cAMP pathway by PDE type 4 (PDE4) favors tumor progression. For example, in me... | ['Apoptosis', 'Biomarkers, Tumor', 'Cell Differentiation', 'Cell Movement', 'Cell Proliferation', 'Cyclic Nucleotide Phosphodiesterases, Type 4', 'Focal Adhesion Kinase 1', 'Humans', 'Melanocytes', 'Melanoma', 'Mutation', 'Neoplasm Invasiveness', 'Neoplasm Staging', 'Phosphorylation', 'Prognosis', 'Proto-Oncogene Prote... | 28,092,671 | [['G04.146.954.035'], ['D23.101.140'], ['G04.152'], ['G04.198', 'G07.568.500.180'], ['G04.161.750', 'G07.345.249.410.750'], ['D08.811.277.352.640.150.400', 'D12.644.360.008.400', 'D12.776.476.008.400'], ['D08.811.913.696.620.682.725.049.500', 'D12.776.744.493'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.40... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The ultrastructural disruption of the glomerular basement membrane in diabetic nephropathy revealed by "tissue negative staining method". | To clarify the ultrastructural changes of the glomerular basement membrane (GBM) in diabetic nephropathy, the renal tissues of the patients with diabetic nephropathy were examined by electron microscopy using our newly devised "tissue negative staining method." A fine meshwork structure consisting of fibrils forming th... | ['Basement Membrane', 'Biopsy', 'Capillaries', 'Diabetes Mellitus, Type 2', 'Diabetic Nephropathies', 'Endothelium, Vascular', 'Humans', 'Kidney Glomerulus', 'Microscopy, Electron', 'Nephrotic Syndrome', 'Proteinuria', 'Renal Circulation'] | 8,573,748 | [['A10.272.220', 'A10.615.179'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['A07.015.461.165'], ['C18.452.394.750.149', 'C19.246.300'], ['C12.777.419.192', 'C13.351.968.419.192', 'C19.246.099.875'], ['A07.015.700.500', ... | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Should patients with psychogenic nonepileptic seizures be allowed to drive? Recommendations of German experts. | In the absence of evidence-based regulations on the driving ability of patients with psychogenic nonepileptic seizures (PNES), we asked 41 German epileptologists via e-mail for their recommendations on driving with PNES. This survey was modeled on an earlier study by Benbadis et al. in the United States and was compare... | ['Automobile Driving', 'Electronic Mail', 'Expert Testimony', 'Germany', 'Humans', 'Neurology', 'Psychophysiologic Disorders', 'Seizures'] | 19,853,517 | [['I03.125'], ['L01.178.847.249', 'L01.559.423.906.377.333'], ['I01.880.604.583.232', 'N03.706.535.253'], ['Z01.542.315'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H02.403.600'], ['C23.888.592.700'], ['C10.597.742', 'C23.888.592.742']] | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Information Science [L]', 'Health Care [N]', 'Geographicals [Z]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 |
Prevalence and correlates of traumatic brain injury among delinquent youths. | BACKGROUND: Delinquent youth frequently exhibit high-risk behaviours that can result in serious injury. However, little is known about traumatic brain injuries (TBIs) and their correlates in this population.AIMS: To examine the period prevalence and correlates of TBIs in delinquent youths.METHOD: Interviews were conduc... | ['Adolescent', 'Antisocial Personality Disorder', 'Attitude to Health', 'Brain Injuries', 'Child', 'Cognition Disorders', 'Comorbidity', 'Conduct Disorder', 'Crime Victims', 'Female', 'Humans', 'Juvenile Delinquency', 'Male', 'Missouri', 'Peer Group', 'Prevalence', 'Regression Analysis', 'Risk Factors', 'Risk-Taking', ... | 18,803,295 | [['M01.060.057'], ['F03.675.050'], ['F01.100.150', 'N05.300.150'], ['C10.228.140.199', 'C10.900.300.087', 'C26.915.300.200'], ['M01.060.406'], ['F03.615.250'], ['N05.715.350.225', 'N06.850.490.687'], ['F03.625.094.300'], ['M01.135'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I01.880.735.479'], ['Z01.107.567.87... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Profound approach to check legitimacy of an old technique used to gauge palatal rugae. | Aims: The present study aimed at assessing two fixed points of reference from where the mesial and distal point of all rugae can be measured so that the exact movement of particular rugae in any direction can be evaluated and assessing the changes in the palatal rugae after orthodontic treatment.Methods: A longitudinal... | ['Adolescent', 'Adult', 'Anthropometry', 'Dental Casting Technique', 'Female', 'Forensic Sciences', 'Humans', 'Longitudinal Studies', 'Male', 'Mouth Mucosa', 'Orthodontics', 'Palate', 'Palate, Hard', 'Treatment Outcome', 'Young Adult'] | 32,031,092 | [['M01.060.057'], ['M01.060.116'], ['E01.370.600.024', 'E05.041', 'N06.850.505.200.100'], ['E06.780.250', 'E06.912.115'], ['I01.198.780'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.500.750.500', 'N05.715.360.330.500.750.500', 'N06.850.520.450.500.750.500'], ['A10.615.550.599', 'A14.549.512'], ['E06... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Anatomy [A]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 |
Determination of 13C isotopic enrichment of valine and threonine by GC-C-IRMS after formation of the N(O,S)-ethoxycarbonyl ethyl ester derivatives of the amino acids. | We describe a new method of assessing, in a single run, (13)C isotopic enrichment of both Val and Thr by gas chromatography-combustion-isotope-ratio mass spectrometry (GC-C-IRMS). This method characterised by a rapid one-step derivatisation procedure performed at room temperature to form the N(O,S)-ethoxycarbonyl ethyl... | ['Amino Acids', 'Animals', 'Carbon Isotopes', 'Esters', 'Ethyl Ethers', 'Gas Chromatography-Mass Spectrometry', 'Intestinal Mucosa', 'Male', 'Protein Biosynthesis', 'Rats', 'Rats, Sprague-Dawley', 'Reproducibility of Results', 'Sensitivity and Specificity', 'Threonine', 'Time Factors', 'Valine'] | 17,468,859 | [['D12.125'], ['B01.050'], ['D01.268.150.075', 'D01.496.123'], ['D02.241.400'], ['D02.355.417'], ['E05.196.181.349.500', 'E05.196.566.500'], ['A03.556.124.369', 'A10.615.550.444'], ['G02.111.660.871', 'G03.734.871', 'G05.297.670'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.7... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Effectiveness of noncoplanar IMRT planning using a parallelized multiresolution beam angle optimization method for paranasal sinus carcinoma. | PURPOSE: To determine the effectiveness of noncoplanar beam configurations and the benefit of plans using fewer but optimally placed beams designed by a parallelized multiple-resolution beam angle optimization (PMBAO) approach.METHODS AND MATERIALS: The PMBAO approach uses a combination of coplanar and noncoplanar beam... | ['Humans', 'Paranasal Sinus Neoplasms', 'Radiography', 'Radiotherapy Dosage', 'Radiotherapy Planning, Computer-Assisted', 'Radiotherapy, Conformal'] | 16,168,851 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.443.665.650.693', 'C08.460.669.693', 'C08.460.692.503', 'C08.785.600.693', 'C09.603.669.693', 'C09.603.692.503', 'C09.647.685.693'], ['E01.370.350.700'], ['E02.815.639'], ['E02.950.825', 'L01.313.500.750.100.710.600.608'], ['E02.815.635.700', 'L01.313.500.750.... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Metabolic regulation is sufficient for global and robust coordination of glucose uptake, catabolism, energy production and growth in Escherichia coli. | The metabolism of microorganisms is regulated through two main mechanisms: changes of enzyme capacities as a consequence of gene expression modulation ("hierarchical control") and changes of enzyme activities through metabolite-enzyme interactions. An increasing body of evidence indicates that hierarchical control is i... | ['Cell Proliferation', 'Computer Simulation', 'Energy Metabolism', 'Escherichia coli', 'Gene Expression Regulation, Bacterial', 'Gene Expression Regulation, Enzymologic', 'Glucose', 'Metabolic Flux Analysis', 'Metabolic Networks and Pathways', 'Metabolism', 'Models, Biological', 'Signal Transduction'] | 28,187,134 | [['G04.161.750', 'G07.345.249.410.750'], ['L01.224.160'], ['G03.295'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['G05.308.300'], ['G05.308.320'], ['D09.947.875.359.448'], ['E01.370.225.500.810', 'E05.200.500.810', 'E05.242.654'], ['G03.493'], ['G03'], ['E05.599.395'], ['G02.111.820', 'G04.835']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Nuclear DNA content of non-endemic Burkitt's lymphoma. | The nuclear DNA content of 26 non-endemic Burkitt's lymphomas was studied by flow cytometry. Eighteen of the tumours showed a pattern characteristic for diploid chromosome distribution, while eight of the tumours were aneuploid. Six of the aneuploid tumours showed an almost diploid, aneuploid DNA index, while two were ... | ['Adolescent', 'Adult', 'Aged', 'Burkitt Lymphoma', 'Cell Nucleus', 'Child', 'Child, Preschool', 'DNA, Neoplasm', 'Female', 'Flow Cytometry', 'Humans', 'Interphase', 'Male', 'Middle Aged', 'Neoplasm Staging'] | 3,680,544 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['C01.925.256.466.313.165', 'C01.925.928.313.165', 'C04.557.386.480.150.165', 'C15.604.515.569.480.150.165', 'C20.683.515.761.480.150.165'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['M01.060.406'], ['M01.060.406.448'], ['D13.444.308.425'], ['E01.370.22... | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Spatiotemporal organization, regulation, and functions of tractions during neutrophil chemotaxis. | Despite recent advances in our understanding of biochemical regulation of neutrophil chemotaxis, little is known about how mechanical factors control neutrophils' persistent polarity and rapid motility. Here, using a human neutrophil-like cell line and human primary neutrophils, we describe a dynamic spatiotemporal pat... | ['Cell Adhesion', 'Cell Line', 'Cells, Cultured', 'Chemotaxis, Leukocyte', 'Humans', 'Integrin alpha5beta1', 'Myosin Type II', 'Myosin-Light-Chain Kinase', 'Neutrophils'] | 20,616,216 | [['G04.022'], ['A11.251.210'], ['A11.251'], ['G04.198.424.233'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.395.550.625.379', 'D12.776.543.550.625.379', 'D12.776.543.750.705.408.530.750', 'D12.776.543.750.705.408.850.349', 'D12.776.543.750.705.675.460', 'D12.776.543.750.705.876.374'], ['D05.750.078.730.... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The assessment of contractile reserve after thrombolytic therapy for acute myocardial infarction. | "Stunned" myocardium prevents the assessment of myocardial salvage after streptokinase. In order to unmask "stunning," we sought to evaluate left ventricular inotropic contractile reserve of patients after streptokinase. Radionuclide ventriculograms were obtained in 75 consecutive patients 2 weeks after myocardial infa... | ['Adult', 'Blood Pressure', 'Female', 'Heart', 'Heart Rate', 'Humans', 'Isoproterenol', 'Male', 'Middle Aged', 'Myocardial Contraction', 'Myocardial Infarction', 'Radionuclide Imaging', 'Sodium Pertechnetate Tc 99m', 'Stimulation, Chemical', 'Streptokinase', 'Stroke Volume', 'Time Factors'] | 3,010,690 | [['M01.060.116'], ['E01.370.600.875.249', 'G09.330.380.076'], ['A07.541'], ['E01.370.600.875.500', 'G09.330.380.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.033.100.291.439', 'D02.092.063.291.439', 'D02.092.311.649', 'D02.455.426.559.389.657.166.175.649'], ['M01.060.116.630'], ['G09.330.580', 'G11.427.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Electronic transport in graphitic nanoribbon films. | We fabricate, pattern, and analyze thin films composed of multilayer graphene nanoribbons. These films are conductive at room temperature but depict noticeable insulating behavior at low temperatures (<20 K) due to their disordered structure. We study the transport in this strong localization regime by analyzing the de... | ['Computer Simulation', 'Electron Transport', 'Graphite', 'Macromolecular Substances', 'Materials Testing', 'Membranes, Artificial', 'Models, Chemical', 'Molecular Conformation', 'Nanostructures', 'Particle Size', 'Surface Properties'] | 21,341,738 | [['L01.224.160'], ['G02.111.248', 'G03.295.531.403', 'G03.493.350'], ['D01.268.150.300', 'D01.578.300'], ['D05'], ['E05.570'], ['D25.479', 'J01.637.051.479', 'J01.637.087.500'], ['E05.599.495'], ['G02.111.570.820'], ['J01.637.512'], ['G02.712'], ['G02.860']] | ['Information Science [L]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Effects of receptor concentration, media pH and storage on nicotinic receptor-transmitted signal in a fiber-optic biosensor. | The optical signal generated by a nicotinic acetylcholine receptor (nAChR)-based optical biosensor was dependent on the density of toxin binding sites (i.e. receptors) immobilized on the surface of the fiber. The maximum density of nAChR receptors absorbed on the optic fibers, measured using [125I]-alpha-bungarotoxin (... | ['Animals', 'Biosensing Techniques', 'Bungarotoxins', 'Fiber Optic Technology', 'Fluorescein', 'Fluoresceins', 'Fluorometry', 'Hydrogen-Ion Concentration', 'In Vitro Techniques', 'Iodine Radioisotopes', 'Optical Fibers', 'Receptors, Nicotinic', 'Signal Transduction'] | 2,049,167 | [['B01.050'], ['E05.601.043'], ['D20.888.850.325.139', 'D23.946.833.850.325.139'], ['H01.671.617.249'], ['D02.455.426.779.347.390', 'D03.633.300.953.275.390', 'D04.711.347.390'], ['D02.455.426.779.347', 'D03.633.300.953.275', 'D04.711.347'], ['E05.196.712.516.600'], ['G02.300'], ['E05.481'], ['D01.268.380.400.500.496',... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Bifurcation control of a seizing human cortex. | We consider as a mathematical model of human cortical electrical activity a system of fourteen ordinary differential equations. With appropriate parameters, the model produces activity characteristic of a seizure. To prevent such seizures, we incorporate feedback controllers into the model dynamics. We show that three ... | ['Action Potentials', 'Biological Clocks', 'Cerebral Cortex', 'Computer Simulation', 'Electroencephalography', 'Feedback', 'Humans', 'Models, Neurological', 'Nerve Net', 'Neurons', 'Seizures'] | 16,711,857 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['G07.180.562.094'], ['A08.186.211.200.885.287.500'], ['L01.224.160'], ['E01.370.376.300', 'E01.370.405.245'], ['L01.906.394.211'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.395.642'], ['A08.511'], ['A08.675', 'A11.671'], ['C10.597.742', 'C23.888.... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Distant evolution of kidney arteriolar lesions and hypertension after pregnancy toxemia. | 60 patients were studied 3 months to 4 years after pregnancy. All had high pressure, gross proteinuria, and edema. In many cases, typical glomerular lesions and proteinuria disappeared rapidly. When arteriolar lesions are of grade I or II, they progressively disappear or remain unchanged and blood pressure returns to n... | ['Adult', 'Arterioles', 'Endothelium', 'Female', 'Follow-Up Studies', 'Humans', 'Hypertension', 'Hypertension, Renal', 'Kidney', 'Pre-Eclampsia', 'Pregnancy', 'Prognosis'] | 7,453,917 | [['M01.060.116'], ['A07.015.114.060', 'A07.015.461.080'], ['A10.272.491'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['C12.777.419.331', 'C13.351.968.419.331', 'C14.907.489.631'], ['A05.810.453'], ['C13.70... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Mindfulness-based cognitive therapy for depression: replication and exploration of differential relapse prevention effects. | Recovered recurrently depressed patients were randomized to treatment as usual (TAU) or TAU plus mindfulness-based cognitive therapy (MBCT). Replicating previous findings, MBCT reduced relapse from 78% to 36% in 55 patients with 3 or more previous episodes; but in 18 patients with only 2 (recent) episodes corresponding... | ['Attitude to Health', 'Cognitive Behavioral Therapy', 'Depressive Disorder, Major', 'Diagnostic and Statistical Manual of Mental Disorders', 'Female', 'Humans', 'Male', 'Middle Aged', 'Secondary Prevention', 'Severity of Illness Index'] | 14,756,612 | [['F01.100.150', 'N05.300.150'], ['F04.754.137.350'], ['F03.600.300.375'], ['L01.453.245.945.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E02.897', 'N02.421.726.825', 'N06.850.780.750'], ['E05.318.308.980.438.475.456.500', 'N05.715.360.300.800.438.375.364.500', 'N06.850.520.308.980.438... | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Information Science [L]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
The structure of coral allene oxide synthase reveals a catalase adapted for metabolism of a fatty acid hydroperoxide. | 8R-Lipoxygenase and allene oxide synthase (AOS) are parts of a naturally occurring fusion protein from the coral Plexaura homomalla. AOS catalyses the production of an unstable epoxide (an allene oxide) from the fatty acid hydroperoxide generated by the lipoxygenase activity. Here, we report the structure of the AOS do... | ['Animals', 'Anthozoa', 'Binding Sites', 'Catalase', 'Crystallization', 'Intramolecular Oxidoreductases', 'Lipid Peroxides', 'Recombinant Fusion Proteins'] | 15,625,113 | [['B01.050'], ['B01.050.500.308.237'], ['G02.111.570.120'], ['D08.811.682.732.332'], ['E05.196.300', 'G02.171'], ['D08.811.399.475'], ['D01.248.497.158.685.750.637', 'D01.339.431.374.637', 'D01.650.550.750.600', 'D02.389.338.450', 'D10.440'], ['D12.776.828.300']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The use of synthetic linear tetrapyrroles to probe the verdin sites of human biliverdin-IXalpha reductase and human biliverdin-IXbeta reductase. | Many vertebrate species express two enzymes that are capable of catalysing the reduction of various isomers of biliverdin. Biliverdin-IXalpha reductase (BVR-A) is most active with its physiological substrate biliverdin-IXalpha, but can also reduce the three other biliverdin isomers IXbeta, IXdelta and IXgamma. Biliverd... | ['Binding Sites', 'Humans', 'Kinetics', 'Ligands', 'Molecular Probe Techniques', 'Molecular Probes', 'Oxidoreductases Acting on CH-CH Group Donors', 'Porphyrins', 'Protein Binding', 'Substrate Specificity', 'Tetrapyrroles'] | 19,614,742 | [['G02.111.570.120'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.374.661', 'G02.111.490'], ['D27.720.470.480'], ['E05.601'], ['D27.505.259.750', 'D27.720.470.530'], ['D08.811.682.660'], ['D03.383.129.578.840.500', 'D03.633.400.909.500', 'D04.345.783.500', 'D23.767.727'], ['G02.111.679', 'G03.808'], ['G02.11... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Online solid-phase extraction-liquid chromatography-mass spectrometry to determine free sterols in human serum. | An automated method for analyzing free non-cholesterol sterols in human serum using online solid phase extraction-liquid chromatography-mass spectrometry is proposed herein. The method allows the determination of three phytosterols (sitosterol, stigmasterol and campesterol) and two cholesterol precursors (desmosterol a... | ['Cholesterol', 'Chromatography, Liquid', 'Desmosterol', 'Humans', 'Lanosterol', 'Limit of Detection', 'Mass Spectrometry', 'Phytosterols', 'Sitosterols', 'Solid Phase Extraction', 'Stigmasterol'] | 25,476,366 | [['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['E05.196.181.400'], ['D04.210.500.247.222.222.347.231', 'D04.210.500.247.808.197.250.281', 'D10.570.938.208.320.297'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.455.849.919.383', 'D04.210.500.247.222.222.347.557', 'D04.210.500.247... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Ideal cardiovascular health associated with fatty liver: Results from a multi-ethnic survey. | BACKGROUND AND AIMS: Little is known about the role of liver enzymes as predictors of non-liver-related morbidity and mortality. The ideal cardiovascular health (CVH) score proposed by the American Heart Association (AHA) can be used to predict mortality and morbidity. We investigated the association of the CVH score w... | ['Adult', 'Blood Glucose', 'Blood Pressure', 'Cardiovascular System', 'Cholesterol', 'Cross-Sectional Studies', 'Fasting', 'Female', 'Health Behavior', 'Health Status Indicators', 'Humans', 'Male', 'Middle Aged', 'Non-alcoholic Fatty Liver Disease'] | 30,878,840 | [['M01.060.116'], ['D09.947.875.359.448.500'], ['E01.370.600.875.249', 'G09.330.380.076'], ['A07'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['F01.145.407.400', 'G07.203.650.240.587', 'G07.203.650.353.400'],... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The impact of behavioral couple therapy on attachment in distressed couples. | Emotion-focused therapy (EFT; Greenberg & Johnson, Emotionally focused therapy for couples. New York: Guilford Press) is anchored in attachment theory (Johnson, 2003 Attachment processes in couples and families. New York: Guilford) and considers change in attachment schemas essential in the process of improving satisfa... | ['Adult', 'Cognitive Behavioral Therapy', 'Couples Therapy', 'Family Conflict', 'Female', 'Humans', 'Interpersonal Relations', 'Male', 'Object Attachment', 'Psychological Tests', 'Surveys and Questionnaires', 'Treatment Outcome'] | 25,800,417 | [['M01.060.116'], ['F04.754.137.350'], ['F04.754.864.581.136'], ['F01.829.263.370.054', 'F01.829.401.142'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.401'], ['F02.739.794.624'], ['F04.711'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980'], ['E01.789.800', 'N04.761.559.590.800', 'N05.7... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Marine Ï-3 polyunsaturated fatty acids induce sex-specific changes in reinforcer-controlled behaviour and neurotransmitter metabolism in a spontaneously hypertensive rat model of ADHD. | BACKGROUND: Previous reports suggest that omega-3 (n-3) polyunsaturated fatty acids (PUFA) supplements may reduce ADHD-like behaviour. Our aim was to investigate potential effects of n-3 PUFA supplementation in an animal model of ADHD.METHODS: We used spontaneously hypertensive rats (SHR). SHR dams were given n-3 PUFA ... | ['Animals', 'Animals, Newborn', 'Attention Deficit Disorder with Hyperactivity', 'Disease Models, Animal', 'Fatty Acids, Omega-3', 'Female', 'Humans', 'Hypertension', 'Male', 'Neurotransmitter Agents', 'Pregnancy', 'Rats', 'Rats, Inbred SHR', 'Rats, Inbred WKY', 'Reinforcement, Psychology', 'Sex Characteristics'] | 23,228,189 | [['B01.050'], ['B01.050.050.282'], ['F03.625.094.150'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['D10.212.302.380.410', 'D10.251.355.337', 'D10.627.430.450'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['D27.505.519.625', 'D27.505.696.577'], ['G08.686.784.769'], ['B01.050.150.900.649.313.9... | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
DNA sequence profiles of the colorectal cancer critical gene set KRAS-BRAF-PIK3CA-PTEN-TP53 related to age at disease onset. | The incidence of colorectal cancer (CRC) increases with age and early onset indicates an increased likelihood for genetic predisposition for this disease. The somatic genetics of tumor development in relation to patient age remains mostly unknown. We have examined the mutation status of five known cancer critical genes... | ['Age Factors', 'Age of Onset', 'Aged', 'Class I Phosphatidylinositol 3-Kinases', 'Colorectal Neoplasms', 'DNA Mutational Analysis', 'Female', 'Genetic Predisposition to Disease', 'Humans', 'Kaplan-Meier Estimate', 'Male', 'Microsatellite Instability', 'Middle Aged', 'Mutation', 'Neoplasm Staging', 'PTEN Phosphohydrola... | 21,103,049 | [['N05.715.350.075', 'N06.850.490.250'], ['N05.715.350.075.100', 'N06.850.490.250.100'], ['M01.060.116.100'], ['D08.811.913.696.620.500.100.100', 'D08.811.913.696.620.500.200.100', 'D12.776.476.162'], ['C04.588.274.476.411.307', 'C06.301.371.411.307', 'C06.405.249.411.307', 'C06.405.469.158.356', 'C06.405.469.491.307',... | ['Health Care [N]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Increased proteasome degradation of cyclin-dependent kinase inhibitor p27 is associated with a decreased overall survival in mantle cell lymphoma. | Mantle cell lymphoma (MCL) is an aggressive neoplasm characterized by the deregulated expression of cyclin D1 by t(11;14). The molecular mechanisms responsible for MCL's clinical behavior remain unclear. The authors have investigated the expression of p53, E2F-1, and the CDK inhibitors p27 and p21 in 110 MCLs, relating... | ['B-Lymphocytes', 'Biomarkers, Tumor', 'Carrier Proteins', 'Cell Cycle Proteins', 'Cyclin-Dependent Kinase Inhibitor p21', 'Cyclin-Dependent Kinase Inhibitor p27', 'Cyclin-Dependent Kinases', 'Cyclins', 'Cysteine Endopeptidases', 'DNA-Binding Proteins', 'E2F Transcription Factors', 'E2F1 Transcription Factor', 'Humans'... | 10,627,471 | [['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['D23.101.140'], ['D12.776.157'], ['D12.776.167'], ['D12.644.360.225.500', 'D12.776.157.687.250', 'D12.776.167.187.500', 'D12.776.476.225.500', 'D12.776.624.776.355.500', 'D12.776.660.720.250'], ['D... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
DISC1 mRNA expression is not influenced by common Cis-acting regulatory polymorphisms or imprinting. | The hypothesis that genetic variation in Disrupted in Schizophrenia 1 (DISC1) influences risk of schizophrenia and other major psychiatric disorders is supported by a growing body of genetic association data and plausible functional biology. Risk of psychiatric disorder is not attributable to non-synonymous changes tha... | ['Base Sequence', 'Brain', 'Frameshift Mutation', 'Genetic Predisposition to Disease', 'Genomic Imprinting', 'Humans', 'Mental Disorders', 'Nerve Tissue Proteins', 'Polymorphism, Genetic', 'Promoter Regions, Genetic', 'RNA, Messenger', 'Regulatory Elements, Transcriptional', 'Repetitive Sequences, Nucleic Acid', 'Schiz... | 18,270,998 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A08.186.211'], ['G05.365.590.265'], ['C23.550.291.687.500', 'G05.380.355'], ['G05.308.203.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F03'], ['D12.776.631'], ['G05.365.795'], ['G02.111.570.080.689.675', 'G05.360.080.689.675', 'G05.360.340.024.3... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Neonatal jaundice, autism, and other disorders of psychological development. | OBJECTIVES: The goals were to study the association between neonatal jaundice and disorders of psychological development in a national, population-based cohort and to study whether gestational age, parity, and season of birth influenced that association.METHODS: A population-based, follow-up study of all children born ... | ['Adult', 'Birth Weight', 'Causality', 'Child', 'Child Development Disorders, Pervasive', 'Child, Preschool', 'Cross-Sectional Studies', 'Denmark', 'Developmental Disabilities', 'Female', 'Follow-Up Studies', 'Gestational Age', 'Humans', 'Infant', 'Infant, Newborn', 'Intellectual Disability', 'Jaundice, Neonatal', 'Mal... | 20,937,652 | [['M01.060.116'], ['C23.888.144.186', 'E01.370.600.115.100.160.120.186', 'E05.041.124.160.750.149', 'G07.100.100.160.120.186', 'G07.345.249.314.120.186'], ['N05.715.350.200', 'N06.850.490.625'], ['M01.060.406'], ['F03.625.164'], ['M01.060.406.448'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.50... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Importation of chloroquine-resistant Plasmodium falciparum by Guatemalan peacekeepers returning from the Democratic Republic of the Congo. | BACKGROUND: Malaria elimination is being pursued in five of seven Central American countries. Military personnel returning from peacekeeping missions in sub-Saharan Africa could import chloroquine-resistant Plasmodium falciparum, posing a threat to elimination and to the continued efficacy of first-line chloroquine (CQ... | ['Adult', 'Antimalarials', 'Chloroquine', 'Democratic Republic of the Congo', 'Drug Resistance', 'Guatemala', 'Humans', 'Malaria, Falciparum', 'Male', 'Middle Aged', 'Military Personnel', 'Plasmodium falciparum', 'Travel', 'Young Adult'] | 24,060,234 | [['M01.060.116'], ['D27.505.954.122.250.100.085'], ['D03.633.100.810.050.180'], ['Z01.058.290.100.220'], ['G07.690.773.984'], ['Z01.107.169.454'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C01.610.752.530.650', 'C01.920.875.650'], ['M01.060.116.630'], ['M01.526.625'], ['B01.043.075.380.611.561'], ['I03.883'], ... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 |
[Contemporary views on the problem of sepsis]. | Sepsis is due to its lethality, which varies round 25%, one of the major problems of contemporary clinical medicine. Classical therapeutic approaches, i.e. chemotherapy, surgical elimination of foci and intensive therapy focused on maintenance of vital functions have obviously reached the limit of effectiveness beyond ... | ['Humans', 'Sepsis'] | 8,168,168 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['C01.757', 'C23.550.470.790.500']] | ['Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Comparison of treadmill and cycle ergometer measurements of force-velocity relationships and power output. | Since body balance and weight-bearing factors present while running on the treadmill might cause additional muscle recruitment and thus could influence the force-velocity relationship and power, the present study was undertaken to find out whether the F-V and F-P relationships measured while running on the treadmill ar... | ['Adult', 'Bicycling', 'Biomechanical Phenomena', 'Exercise', 'Exercise Test', 'Humans', 'Male', 'Movement', 'Muscle, Skeletal', 'Running'] | 10,333,097 | [['M01.060.116'], ['I03.450.642.845.140'], ['G01.154.090', 'G01.374.089'], ['G11.427.410.698.277', 'I03.350'], ['E01.370.370.380.250', 'E01.370.386.700.250', 'E05.333.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G07.568', 'G11.427.410'], ['A02.633.567', 'A10.690.552.500'], ['G11.427.410.568.610', 'G11.427.... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Neurons in the guinea-pig lateral septum generate rhythmic bursting activities, in vitro, following application of carbachol. | We used intracellular recordings in a guinea pig brain slice preparation to characterize the actions of carbachol in neurons of the mediolateral part of the lateral septum (LSml). Bath application of carbachol elicited depolarization and rhythmic bursting activities in a majority of neurons (61.5%) through muscarinic r... | ['Animals', 'Atropine', 'Carbachol', 'Female', 'Guinea Pigs', 'In Vitro Techniques', 'Membrane Potentials', 'Muscarine', 'Neurons', 'Nicotine', 'Periodicity', 'Septal Nuclei', 'Synapses', 'Tetrodotoxin'] | 9,469,664 | [['B01.050'], ['D02.145.074.722.229.199', 'D03.132.760.180.572.199', 'D03.132.889.180.648.199', 'D03.605.084.500.722.229.199', 'D03.605.869.229.199'], ['D02.092.877.883.333.115', 'D02.675.276.232.115'], ['B01.050.150.900.649.313.992.550'], ['E05.481'], ['G01.154.535', 'G04.580', 'G07.265.675', 'G11.561.570'], ['D02.092... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The time course and effect on serum electrolytes of oral sodium phosphates solution in healthy male and female volunteers. | BACKGROUND: Although oral sodium phosphates solution is used extensively for bowel preparation, the pharmacokinetic profile of 2 x 45 mL oral sodium phosphates solution has not been reported.OBJECTIVES: The primary objective of this study was to evaluate the time course and degree of electrolyte shifts in two age group... | ['Administration, Oral', 'Adult', 'Age Factors', 'Aged', 'Electrolytes', 'Female', 'Humans', 'Male', 'Middle Aged', 'Pharmaceutical Solutions', 'Phosphates', 'Sex Factors', 'Time Factors'] | 18,000,319 | [['E02.319.267.100'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['D01.248'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['D26.776.708', 'D27.505.954.578', 'D27.720.752'], ['D01.029.260.700.675.374', 'D01.248.497.158.730', 'D01.695.625.675.650'], ['N05.715.3... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Shared parameter model for competing risks and different data summaries in meta-analysis: Implications for common and rare outcomes. | This paper considers the problem in aggregate data meta-analysis of studies reporting multiple competing binary outcomes and of studies using different summary formats for those outcomes. For example, some may report numbers of patients with at least one of each outcome while others may report the total number of such ... | ['Administration, Oral', 'Algorithms', 'Anticoagulants', 'Asymptomatic Infections', 'Atrial Fibrillation', 'Computer Simulation', 'Dabigatran', 'Hemorrhage', 'Humans', 'Likelihood Functions', 'Meta-Analysis as Topic', 'Motivation', 'Myocardial Infarction', 'Odds Ratio', 'Proportional Hazards Models', 'Randomized Contro... | 31,330,089 | [['E02.319.267.100'], ['G17.035', 'L01.224.050'], ['D27.505.954.502.119'], ['C01.125', 'C23.550.291.187.500'], ['C14.280.067.198', 'C23.550.073.198'], ['L01.224.160'], ['D03.383.725.192', 'D03.633.100.103.280'], ['C23.550.414'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.475', 'E05.318.740.600.4... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Association between indoxyl sulfate and cardiac dysfunction and prognosis in patients with dilated cardiomyopathy. | BACKGROUND: Serum indoxyl sulfate (IS) is a uremic toxin that accelerates the progression of chronic kidney disease (CKD). The aim of this study was to determine whether serum IS is associated with hemodynamic parameters or cardiac events in patients with nonischemic dilated cardiomyopathy (DCM).METHODS AND RESULTS: Th... | ['Adult', 'Aged', 'Biomarkers', 'Cardiomyopathy, Dilated', 'Disease Progression', 'Female', 'Heart Failure', 'Humans', 'Indican', 'Kaplan-Meier Estimate', 'Male', 'Middle Aged', 'Natriuretic Peptide, Brain', 'Predictive Value of Tests', 'Prognosis', 'Renal Insufficiency, Chronic', 'Risk Factors', 'Stroke Volume', 'Ultr... | 23,100,090 | [['M01.060.116'], ['M01.060.116.100'], ['D23.101'], ['C14.280.195.160', 'C14.280.238.070', 'C16.320.488.750'], ['C23.550.291.656'], ['C14.280.434'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.633.100.473.393'], ['E05.318.740.998.650', 'N05.715.360.750.795.650', 'N06.850.520.830.998.650'], ['M01.060.116.630'... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Phospho-kinase profile of triple negative breast cancer and androgen receptor signaling. | BACKGROUND: The androgen receptor (AR) plays a central role in the oncogenesis of different tumors, as is the case in prostate cancer. In triple negative breast cancer (TNBC) a gene expression classification has described different subgroups including a luminal androgen subtype. The AR can be controlled by several mech... | ['Anilides', 'Cell Line, Tumor', 'Cell Proliferation', 'ErbB Receptors', 'Gene Expression Regulation, Neoplastic', 'Humans', 'MAP Kinase Signaling System', 'Molecular Targeted Therapy', 'Nitriles', 'Receptors, Androgen', 'TOR Serine-Threonine Kinases', 'Tosyl Compounds', 'Triple Negative Breast Neoplasms'] | 24,779,793 | [['D02.065.199', 'D02.092.146.113'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.161.750', 'G07.345.249.410.750'], ['D08.811.913.696.620.682.725.400.009', 'D12.776.543.750.630.009', 'D12.776.543.750.750.400.074'], ['G05.308.370'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.111.820.560', 'G03.493.560', 'G0... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Psychiatric and physical comorbidities and their impact on the course of bipolar disorder: A prospective, naturalistic 4-year follow-up study. | OBJECTIVES: The aim of the present study was to increase the available evidence on how physical and psychiatric comorbidities influence the long-term outcome in bipolar I and II disorder.METHODS: We examined the prevalence of comorbid physical (metabolic, cardiovascular, thyroid, and neurological) diseases and psychiat... | ['Adult', 'Austria', 'Bipolar Disorder', 'Cardiovascular Diseases', 'Comorbidity', 'Female', 'Follow-Up Studies', 'Humans', 'International Classification of Diseases', 'Male', 'Mental Disorders', 'Metabolic Diseases', 'Middle Aged', 'Nervous System Diseases', 'Prevalence', 'Prospective Studies', 'Recurrence', 'Thyroid ... | 28,544,558 | [['M01.060.116'], ['Z01.542.088'], ['F03.084.500'], ['C14'], ['N05.715.350.225', 'N06.850.490.687'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.453.245.945.400'], ['F03'], ['C18.452'], ['M01.060.116.630'], ['C10'], ['... | ['Named Groups [M]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Information Science [L]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
The arts as healing. | The relationship between artistic involvement and individual mental health is considered, and the concept of "healing" is differentiated from that of "therapy." Seven properties of art experience are identified which, when developed, have contributed to patients' recovery from mental illness. Implications of these prop... | ['Adolescent', 'Adult', 'Art Therapy', 'Catharsis', 'Creativity', 'Helplessness, Learned', 'Humans', 'Imagination', 'Mental Disorders', 'Psychoanalytic Theory', 'Self Concept', 'Verbal Behavior'] | 6,638,153 | [['M01.060.057'], ['M01.060.116'], ['E02.190.888.124', 'E02.760.169.063.500.100', 'E02.831.100', 'F04.754.070'], ['F04.754.720.107.333'], ['F01.752.264', 'F02.463.785.302'], ['F01.393.398', 'F02.463.425.420'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.188.634'], ['F03'], ['F02.739.794'], ['F01.752.747.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Androgen receptor defects in patients with minimal and partial androgen resistance classified according to a model of androgen-receptor complex energy states. | We have characterized intracellularly the androgen-receptor (A-R) complexes formed by genital skin fibroblasts from 2 unrelated males with qualitative defects of the androgen receptor: one has a small nonhypospadic penis as part of a syndrome of mild androgen resistance; the other was born with ambiguous external genit... | ['Adolescent', 'Androgens', 'Child, Preschool', 'Dihydrotestosterone', 'Drug Resistance', 'Fibroblasts', 'Genitalia, Male', 'Humans', 'Male', 'Metribolone', 'Nandrolone', 'Receptors, Androgen', 'Testosterone', 'Thermodynamics'] | 2,210,624 | [['M01.060.057'], ['D27.505.696.399.472.161'], ['M01.060.406.448'], ['D04.210.500.054.040.248', 'D06.472.334.851.968.964'], ['G07.690.773.984'], ['A11.329.228'], ['A05.360.444'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D04.210.500.365.415.550'], ['D04.210.500.365.415.638', 'D06.472.334.851.968.976'], ['D12.7... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Synthesis of cyclic peptidomimetics from aldol building blocks. | Aldol products (3-hydroxy acids) with an allyl-protected hydroxy group were converted to amino alcohols by Curtius rearrangement. Combination of the carboxylic acid with the amino alcohols gave the amides 10. Ring-closing metathesis led to the 12-membered lactams 12 as mixtures of E/Z-isomers. The scheme was also trans... | ['Alkylation', 'Amides', 'Amination', 'Amino Acids', 'Carboxylic Acids', 'Combinatorial Chemistry Techniques', 'Cyclization', 'Lactams', 'Magnetic Resonance Spectroscopy', 'Molecular Conformation', 'Molecular Mimicry', 'Molecular Structure', 'Peptides, Cyclic', 'Stereoisomerism'] | 12,182,676 | [['G02.111.035', 'G02.607.094', 'G03.059'], ['D02.065'], ['G02.111.053', 'G02.607.110', 'G03.068'], ['D12.125'], ['D02.241'], ['E05.197.312', 'J01.897.836.249.249'], ['G02.111.180', 'G02.607.133', 'G03.208'], ['D02.065.589', 'D03.383.411'], ['E05.196.867.519'], ['G02.111.570.820'], ['G02.111.560', 'G05.545', 'G16.012.7... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
[Poisoning caused by external use of iodoform]. | A case of iodoform toxicity caused by use of 5% iodoformed bandage in occlusive surgical dressings for tamponing of diffuse hemorrhage in pelvic cavity, following amputation for treatment of rectum adenocarcinoma. Despite the frequent use of iodoformed dressings following surgical procedures, the signs and symptoms of ... | ['Aged', 'Bandages', 'Follow-Up Studies', 'Humans', 'Hydrocarbons, Iodinated', 'Male', 'Postoperative Period'] | 7,871,328 | [['M01.060.116.100'], ['E07.101'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.455.526.581'], ['E04.614.750', 'N02.421.585.753.750']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
PGE1 reduces injury in hepatic allografts following preservation. | Prostaglandins of the E series have been shown to decrease renal and hepatic ischemic injury as well as improve hepatic function in patients with primary nonfunction following transplantation. We wished to determine the effect of prostaglandin E1 (PGE1) on hepatic allograft reperfusion injury in the isolated perfused r... | ['Alprostadil', 'Animals', 'Aspartate Aminotransferases', 'Bile', 'L-Lactate Dehydrogenase', 'Liver', 'Liver Circulation', 'Liver Transplantation', 'Male', 'Organ Preservation', 'Oxygen Consumption', 'Rats', 'Rats, Inbred Strains', 'Reperfusion Injury', 'Superoxides', 'Transplantation, Homologous'] | 1,646,912 | [['D10.251.355.255.550.250.100', 'D10.251.355.325.050', 'D23.469.050.175.725.250.100'], ['B01.050'], ['D08.811.913.477.700.225'], ['A12.200.087'], ['D08.811.682.047.551.400', 'D08.811.682.047.820.493'], ['A03.620'], ['G09.330.100.881.552'], ['E02.095.147.725.490', 'E04.210.650', 'E04.936.450.490', 'E04.936.580.490'], [... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Environmental enrichment: the influences of restricted daily exposure and subsequent exposure to uncontrollable stress. | Environmental enrichment has been proposed to enhance an animal's subsequent ability to learn. While this proposal has received considerable support from experiments involving maze tasks, it has received equivocal support from experiments employing operant and pavlovian tasks. The purpose of the present study is two-fo... | ['Animals', 'Appetitive Behavior', 'Arousal', 'Conditioning, Operant', 'Escape Reaction', 'Exploratory Behavior', 'Helplessness, Learned', 'Male', 'Rats', 'Rats, Inbred Strains', 'Reaction Time', 'Reinforcement Schedule', 'Social Environment'] | 1,557,441 | [['B01.050'], ['F01.145.113.111'], ['F02.830.104', 'G11.561.035'], ['F02.463.425.179.509'], ['F01.145.113.780.688', 'F01.145.367', 'F01.145.875.439.500.688', 'G07.568.500.590.688', 'G11.427.410.568.850.688'], ['F01.145.387', 'F01.658.370'], ['F01.393.398', 'F02.463.425.420'], ['B01.050.150.900.649.313.992.635.505.700']... | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
Endocannabinoids mediate neuroprotection after transient focal cerebral ischemia. | The endocannabinoids anandamide (AEA) and palmitoylethanolamide (PEA) act as endogenous protective factors of the brain, using different pathways of neuroprotection against neuronal damage. Although several in vivo and in vitro studies confirmed the neuroprotective efficacy of endocannabinoids, no experimental settings... | ['Animals', 'Brain', 'Cannabinoid Receptor Modulators', 'Endocannabinoids', 'Ischemic Attack, Transient', 'Male', 'Neuroprotective Agents', 'Rats', 'Rats, Wistar', 'Recovery of Function'] | 18,823,959 | [['B01.050'], ['A08.186.211'], ['D27.505.519.625.085', 'D27.505.696.399.472.188'], ['D10.251.265'], ['C10.228.140.300.150.836', 'C14.907.253.092.836'], ['D27.505.696.706.548', 'D27.505.954.427.575'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.900'], ['G16.757']] | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Influence of halothane on contraction at positive membrane potentials in single cells isolated from guinea-pig ventricular muscle. | Actions of halothane were investigated under voltage-clamp conditions in single cells from guinea-pig ventricular muscle. Contraction (measured by an optical method) evoked by step depolarization to 0 mV was consistently reduced by halothane. At positive membrane potentials (+60 mV) 2% halothane did not cause a consist... | ['Animals', 'Guinea Pigs', 'Halothane', 'In Vitro Techniques', 'Isoflurane', 'Membrane Potentials', 'Muscle Contraction', 'Muscles', 'Ventricular Function'] | 2,727,244 | [['B01.050'], ['B01.050.150.900.649.313.992.550'], ['D02.455.526.340'], ['E05.481'], ['D02.355.601.570'], ['G01.154.535', 'G04.580', 'G07.265.675', 'G11.561.570'], ['G11.427.494'], ['A02.633', 'A10.690'], ['G09.330.955']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Early Versus Delayed Use of Ultrasound-Assisted Catheter-Directed Thrombolysis in Patients With Acute Submassive Pulmonary Embolism. | OBJECTIVES: The effect of early vs delayed use of ultrasound-assisted catheter-directed thrombolysis (USAT) on invasive hemodynamics and in-hospital outcomes in patients with acute submassive pulmonary embolism (PE) is not well known.METHODS: We evaluated 41 patients with submassive PE to study the association of early... | ['Acute Disease', 'Cardiac Catheterization', 'Computed Tomography Angiography', 'Female', 'Fibrinolytic Agents', 'Follow-Up Studies', 'Humans', 'Male', 'Middle Aged', 'Pulmonary Embolism', 'Retrospective Studies', 'Thrombolytic Therapy', 'Time-to-Treatment', 'Tissue Plasminogen Activator', 'Tomography, X-Ray Computed',... | 29,715,164 | [['C23.550.291.125'], ['E01.370.370.380.140', 'E02.148.442', 'E05.157.250'], ['E01.370.350.350.810.335', 'E01.370.350.567.250', 'E01.370.350.600.350.700.810.335', 'E01.370.350.700.700.810.335', 'E01.370.350.700.810.810.568', 'E01.370.350.825.810.810.499'], ['D27.505.519.421.750', 'D27.505.954.411.320', 'D27.505.954.502... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Liposomes of controllable size in the range of 40 to 180 nm by defined dialysis of lipid/detergent mixed micelles. | Liposomes, in the size range of 40--180 nm, are formed when lipid and additives are solubilized with detergent, yielding defined mixed micelles, and the detergent is subsequently removed by controlled dialysis. Their most important properties are that they are indeed unilamellar with usefully large encapsulated volumes... | ['Animals', 'Cattle', 'Cholic Acids', 'Colloids', 'Detergents', 'Dialysis', 'Freeze Fracturing', 'Liposomes', 'Micelles', 'Microscopy, Electron', 'Molecular Conformation', 'Phospholipids', 'Surface-Active Agents'] | 7,194,112 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['D04.210.500.105.225', 'D04.210.500.221.430'], ['D20.280', 'D26.255.165'], ['D27.720.877.265', 'J01.516.381'], ['E05.196.353', 'G02.186'], ['E01.370.225.500.620.620.260', 'E01.370.225.750.600.620.260', 'E05.200.500.620.620.260', 'E05.200.750.600.620.260'], ['D25.4... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Affinity chromatography matrices for depletion and purification of casein glycomacropeptide from bovine whey. | Casein glycomacropeptide (CMP) is a 64- amino acid peptide found in cheese whey, which is released after ê-casein specific cleavage by chymosin. CMP lacks aromatic amino acids, a characteristic that makes it usable as a nutritional supplement for people with phenylketonuria. CMP consists of two nonglycosylated isoforms... | ['Adsorption', 'Amino Acids', 'Animals', 'Caseins', 'Cattle', 'Chitosan', 'Chromatography, Affinity', 'Glycosylation', 'Milk', 'N-Acetylneuraminic Acid', 'Peptide Fragments', 'Whey', 'Whey Proteins'] | 27,897,433 | [['G01.030', 'G02.020'], ['D12.125'], ['B01.050'], ['D12.776.256.159.750.207', 'D12.776.744.150'], ['B01.050.150.900.649.313.500.380.271'], ['D05.750.078.139.500', 'D09.698.211.500'], ['E05.196.181.400.170'], ['G02.111.158.812', 'G02.607.299', 'G03.191.812'], ['A12.200.455', 'A12.790', 'G07.203.100.700', 'G07.203.300.3... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Transcriptional response of yellow perch to changes in ambient metal concentrations-A reciprocal field transplantation experiment. | Recent local adaptation to pollution has been evidenced in several organisms inhabiting environments heavily contaminated by metals. Nevertheless, the molecular mechanisms underlying adaptation to high metal concentrations are poorly understood, especially in fishes. Yellow perch (Perca flavescens) populations from lak... | ['Animals', 'Canada', 'Energy Metabolism', 'Fish Proteins', 'Gene Expression Regulation', 'Lakes', 'Liver', 'Metals', 'Perches', 'Water Pollutants, Chemical'] | 26,867,186 | [['B01.050'], ['Z01.107.567.176'], ['G03.295'], ['D12.776.325'], ['G05.308'], ['G01.311.580', 'G16.500.275.280.500', 'N06.230.232.500'], ['A03.620'], ['D01.552'], ['B01.050.150.900.493.602.600'], ['D27.888.284.903.655']] | ['Organisms [B]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Decreased activity of acid alpha-glucosidase in a patient with persistent periocular swelling after infusions of hydroxyethyl starch. | After infusion therapy with hydroxyethyl starch (HES) on account of sudden hearing loss, a 68-year-old woman developed a marked and persistent periocular swelling. This extraordinary adverse effect caused us to search for an explanation by means of histopathology, immunohistochemistry, immunoelectron microscopy and bio... | ['Aged', 'Edema', 'Facial Dermatoses', 'Female', 'Humans', 'Hydroxyethyl Starch Derivatives', 'Plasma Substitutes', 'alpha-Glucosidases'] | 9,640,378 | [['M01.060.116.100'], ['C23.888.277'], ['C17.800.271'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D09.301.915.500', 'D09.698.365.855.500'], ['D27.505.954.502.140.500'], ['D08.811.277.450.420.050']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Conversation as therapy for older adults in residential care: the case for intervention. | Social isolation resulting from sensory loss tends to reduce life satisfaction in older adults. Residence in a long-term care facility such as a nursing home does little to alleviate their communication needs. Potenial communication partners are available (e.g. other residents, family and friends, nursing staff, volunt... | ['Aged', 'Communication', 'Humans', 'Social Isolation', 'Socioenvironmental Therapy', 'Speech Disorders', 'Speech Therapy'] | 7,865,926 | [['M01.060.116.100'], ['F01.145.209', 'L01.143'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.813.781', 'I01.880.853.748'], ['F04.754.864'], ['C10.597.606.150.500.800', 'C23.888.592.604.150.500.800'], ['E02.760.169.063.500.727.552', 'E02.831.727.552']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Information Science [L]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 |
Blood lead levels in Omani children admitted to hospital. | Whole blood lead levels were estimated by atomic absorption analysis in 119 Omani children admitted to hospital. Eighteen per cent of the children were found to have a blood lead level of 1.2 mumol/l or more, 5 per cent were found to have a level above 2.4 mumol/l and 3 per cent had very high levels in excess of 3.4 mu... | ['Adolescent', 'Child', 'Child, Preschool', 'Female', 'Hospitals, District', 'Humans', 'Infant', 'Infant, Newborn', 'Lead Poisoning', 'London', 'Male', 'Oman'] | 2,280,439 | [['M01.060.057'], ['M01.060.406'], ['M01.060.406.448'], ['N02.278.421.510.140'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['C25.723.522.750'], ['Z01.433.553', 'Z01.542.363.300.553'], ['Z01.252.245.500.600']] | ['Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Dealing with noisy absences to optimize species distribution models: an iterative ensemble modelling approach. | Species distribution models (SDMs) are widespread in ecology and conservation biology, but their accuracy can be lowered by non-environmental (noisy) absences that are common in species occurrence data. Here we propose an iterative ensemble modelling (IEM) method to deal with noisy absences and hence improve the predic... | ['Biodiversity', 'Conservation of Natural Resources', 'Ecology', 'Ecosystem', 'Environment', 'Models, Theoretical'] | 23,166,691 | [['G16.500.275.157.049', 'N06.230.124.049'], ['J01.256', 'N06.230.080'], ['H01.158.273.248', 'H01.277.249'], ['G16.500.275.157', 'N06.230.124'], ['G16.500.275', 'N06.230'], ['E05.599']] | ['Phenomena and Processes [G]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 |
Ocular toxicity during adjuvant chemoendocrine therapy for early breast cancer: results from International Breast Cancer Study Group trials. | BACKGROUND: Others have reported ocular toxicity after adjuvant chemoendocrine therapy, but this study looked at ocular toxicity in similarly treated patients from large randomized clinical trials.METHODS: Information was retrieved on incidence and timing of ocular toxicity from the International Breast Cancer Study Gr... | ['Aged', 'Antineoplastic Agents, Hormonal', 'Antineoplastic Combined Chemotherapy Protocols', 'Breast Neoplasms', 'Databases, Factual', 'Eye', 'Eye Diseases', 'Female', 'Humans', 'Male', 'Middle Aged', 'Randomized Controlled Trials as Topic', 'Retrospective Studies', 'Tamoxifen', 'Toremifene', 'Visual Acuity'] | 16,369,994 | [['M01.060.116.100'], ['D27.505.954.248.169'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['C04.588.180', 'C17.800.090.500'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['A01.456.505.420', 'A09.371'], ['C11'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.372.2... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Information Science [L]', 'Anatomy [A]', 'Organisms [B]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Mouse interferon in ascitic fluids. | Mouse interferon was obtained in relatively large volumes by the use of ascitic fluid from mice bearing sarcoma 180/TG and subsequently inoculated with Germiston virus. | ['Animals', 'Arboviruses', 'Ascitic Fluid', 'Injections, Intraperitoneal', 'Interferons', 'Methods', 'Mice', 'Mice, Inbred Strains', 'Neoplasm Transplantation', 'Sarcoma, Experimental'] | 4,853,277 | [['B01.050'], ['B04.080'], ['A12.207.119'], ['E02.319.267.530.490'], ['D12.644.276.374.440', 'D12.776.467.374.440', 'D23.529.374.440'], ['E05.581'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520', 'B01.050.150.900.649.313.992.635.505.500.400'], ['E05.624'], ['C04.557.450.795.830', 'C04.619.857'... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nitric oxide mediates redistribution of intrarenal blood flow during bacteremia. | The normal or hyperdynamic circulatory response during the early phases of the systemic septic response is associated with renal microvascular constriction and can result in renal dysfunction. Intrarenal redistribution of blood flow from the outer cortex to the medulla appears to account for decreased glomerular filtra... | ['Animals', 'Arginine', 'Bacteremia', 'Blood Pressure', 'Escherichia coli Infections', 'Heart Rate', 'Infusions, Intravenous', 'Laser-Doppler Flowmetry', 'Male', 'NG-Nitroarginine Methyl Ester', 'Nitric Oxide', 'Rats', 'Rats, Sprague-Dawley', 'Renal Circulation', 'p-Aminohippuric Acid'] | 7,636,915 | [['B01.050'], ['D12.125.068.050', 'D12.125.095.104', 'D12.125.142.087'], ['C01.150.252.100', 'C01.757.100', 'C23.550.470.790.500.100'], ['E01.370.600.875.249', 'G09.330.380.076'], ['C01.150.252.400.310.330'], ['E01.370.600.875.500', 'G09.330.380.500'], ['E02.319.267.082.500', 'E02.319.267.510.590'], ['E01.370.370.475',... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Severe bronchospasm during rectal carcinoid resection. | The manifestations of carcinoid syndrome result from a variety of hormones secreted by the carcinoid tumour. The minority of patients with carcinoid tumour suffer bronchospasm and flushing. In this report the possibility of carcinoid syndrome in a patient who developed severe bronchospasm during operative manipulation ... | ['Bronchial Spasm', 'Carcinoid Tumor', 'Humans', 'Intraoperative Complications', 'Male', 'Malignant Carcinoid Syndrome', 'Middle Aged', 'Rectal Neoplasms'] | 7,786,271 | [['C08.127.321'], ['C04.557.465.625.650.200', 'C04.557.470.200.025.200', 'C04.557.580.625.650.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.505'], ['C04.557.465.625.650.200.500', 'C04.557.470.200.025.200.500', 'C04.557.580.625.650.200.500'], ['M01.060.116.630'], ['C04.588.274.476.411.307.790', 'C06.... | ['Diseases [C]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A randomized controlled trial on rehabilitation through caregiver-delivered nurse-organized service programs for disabled stroke patients in rural china (the RECOVER trial): design and rationale. | RATIONALE: Stroke is the leading cause of death and disability in rural China. For stroke patients residing in resource-limited rural areas, secondary prevention and rehabilitation are largely unavailable, and where present, are far below evidence-based standards.AIM: This study aims to develop and implement a simplifi... | ['Activities of Daily Living', 'Adolescent', 'Adult', 'Aged', 'Caregivers', 'China', 'Feasibility Studies', 'Follow-Up Studies', 'Humans', 'Middle Aged', 'Motor Activity', 'Nurses', 'Pilot Projects', 'Rural Population', 'Self Care', 'Software', 'Stroke Rehabilitation', 'Telephone', 'Treatment Outcome', 'Young Adult'] | 27,462,096 | [['E02.760.169.063.500.067', 'E02.831.067', 'I03.050', 'N02.421.784.110'], ['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.085', 'M01.526.485.200', 'N02.360.200'], ['Z01.252.474.164'], ['E05.318.372.550', 'E05.337.675', 'N05.715.360.330.550', 'N06.850.520.450.550'], ['E05.318.372.500.750.249', 'N05.715.360... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Named Groups [M]', 'Geographicals [Z]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Disciplines an... | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 |
Solitary maxillary central incisor and short stature. | Seven patients, three males and four females, each with a single (unpaired) deciduous and permanent maxillary central incisor, were studied. All the males and two the female children were growth hormone deficient. One adult woman and a female infant with a single maxillary central incisor were short in stature but had ... | ['Adult', 'Anodontia', 'Child, Preschool', 'Female', 'Growth Disorders', 'Growth Hormone', 'Humans', 'Incisor', 'Infant', 'Male', 'Tooth, Deciduous'] | 925,821 | [['M01.060.116'], ['C07.650.800.100', 'C07.793.700.100', 'C16.131.850.800.100'], ['M01.060.406.448'], ['C23.550.393'], ['D06.472.699.631.525.425', 'D12.644.548.691.525.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A14.549.167.860.425'], ['M01.060.703'], ['A14.549.167.860.700']] | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes. | Following its tyrosine phosphorylation, STAT3 is methylated on K140 by the histone methyl transferase SET9 and demethylated by LSD1 when it is bound to a subset of the promoters that it activates. Methylation of K140 is a negative regulatory event, because its blockade greatly increases the steady-state amount of activ... | ['Active Transport, Cell Nucleus', 'Cell Line', 'Histone Demethylases', 'Histone-Lysine N-Methyltransferase', 'Histones', 'Humans', 'Interleukin-6', 'Lysine', 'Methylation', 'Promoter Regions, Genetic', 'STAT3 Transcription Factor', 'Suppressor of Cytokine Signaling 3 Protein', 'Suppressor of Cytokine Signaling Protein... | 21,098,664 | [['G03.143.310.100', 'G03.143.700.100'], ['A11.251.210'], ['D08.811.682.662.582.475'], ['D08.811.913.555.500.800.200.500'], ['D12.776.157.687.485', 'D12.776.660.720.485', 'D12.776.664.469'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.465.224', 'D12.776.467.374.465.202', 'D23.529.374.465.224'], [... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Typing of multiple single-nucleotide polymorphisms using ribonuclease cleavage of DNA/RNA chimeric single-base extension primers and detection by MALDI-TOF mass spectrometry. | A novel single-base extension (SBE) assay using cleavable and noncleavable SBE primers in the same reaction mix is described. The cleavable SBE primers consisted of deoxyribonucleotides and one ribonucleotide (hereafter denoted chimeric primers), whereas the noncleavable SBE primers consisted of only deoxyribonucleotid... | ['Base Sequence', 'DNA Primers', 'Molecular Sequence Data', 'Polymorphism, Single Nucleotide', 'RNA', 'Ribonucleases', 'Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization'] | 16,097,763 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['L01.453.245.667'], ['G05.365.795.598'], ['D13.444.735'], ['D08.811.277.352.700'], ['E05.196.566.755']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Total Exposure Study Analysis consortium: a cross-sectional study of tobacco exposures. | BACKGROUND: The Total Exposure Study was a stratified, multi-center, cross-sectional study designed to estimate levels of biomarkers of tobacco-specific and non-specific exposure and of potential harm in U.S. adult current cigarette smokers (?one manufactured cigarette per day over the last year) and tobacco product no... | ['Adult', 'African Continental Ancestry Group', 'Biomarkers', 'Chemistry Techniques, Analytical', 'Cotinine', 'Cross-Sectional Studies', 'European Continental Ancestry Group', 'Hispanic Americans', 'Humans', 'Male', 'Nicotine', 'Risk Factors', 'Smoke', 'Smoking', 'Tobacco Use Disorder', 'United States', 'Virginia'] | 26,346,437 | [['M01.060.116'], ['M01.686.508.100'], ['D23.101'], ['E05.196'], ['D03.383.773.812.180'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['M01.686.508.400'], ['M01.686.754.441'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.132.760.570', 'D03.383.725.518'], ['E05.318.740.600.80... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
5-Fluorouracil (NSC-19893), DTIC (NSC-45388), BCNU (NSC-409962), and vincristine (NSC-67574) in advanced colorectal carcinoma. | Thirty-three patients with advanced colorectal carcinoma were treated with 5-day courses of 5-fluorouracil (10 mg/kg/day, iv, Days 1-5), DTIC (3 mg/kg/day, iv, Days 1 and 2), BCNU (1.5 mg/kg/day, iv, Day 1 only), and vincristine (0.025 mg/kg/day, iv, Day 1 only) at 5-week intervals. One patient achieved CR and six pati... | ['Adult', 'Aged', 'Antineoplastic Agents', 'Carmustine', 'Colonic Neoplasms', 'Dacarbazine', 'Drug Therapy, Combination', 'Female', 'Fluorouracil', 'Humans', 'Male', 'Middle Aged', 'Rectal Neoplasms', 'Remission, Spontaneous', 'Vincristine'] | 1,000,517 | [['M01.060.116'], ['M01.060.116.100'], ['D27.505.954.248'], ['D02.065.950.594.247', 'D02.654.692.247'], ['C04.588.274.476.411.307.180', 'C06.301.371.411.307.180', 'C06.405.249.411.307.180', 'C06.405.469.158.356.180', 'C06.405.469.491.307.180'], ['D02.925.200', 'D03.383.129.308.240'], ['E02.319.310'], ['D03.383.742.698.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
An improved extraction method for the HPLC determination of morphine and its metabolites in plasma. | A new, simple and rapid extraction procedure coupled with a combined coulometric-fluorescence HPLC assay is described for the simultaneous determination of morphine (M) and morphine-3-glucuronide (M3G), morphine-6-glucuronide (M6G), and normorphine (NM) in plasma. The effect of concentration and pH of selected ion-pair... | ['Animals', 'Chromatography, High Pressure Liquid', 'Electrochemistry', 'Hydrogen-Ion Concentration', 'Injections, Intravenous', 'Morphine', 'Morphine Derivatives', 'Sheep', 'Spectrometry, Fluorescence'] | 8,357,878 | [['B01.050'], ['E05.196.181.400.300'], ['H01.181.529.307'], ['G02.300'], ['E02.319.267.082.750', 'E02.319.267.530.540'], ['D03.132.577.249.562.571', 'D03.605.497.607.587', 'D03.633.400.686.607.587', 'D04.615.723.795.576.571'], ['D03.132.577.249.562', 'D03.605.497.607', 'D03.633.400.686.607', 'D04.615.723.795.576'], ['B... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Impaired hemodynamic response in the ischemic brain assessed with BOLD fMRI. | The study aims to investigate the effect of cerebral ischemia or hypoperfusion in the evaluation of neural activity with blood-oxygen-level dependent (BOLD) functional magnetic resonance imaging (fMRI), and to examine whether the severity of the compromised hemodynamic status in patients with major cerebral artery dise... | ['Adult', 'Aged', 'Algorithms', 'Brain Ischemia', 'Carotid Stenosis', 'Cerebrovascular Circulation', 'Collateral Circulation', 'Female', 'Hemodynamics', 'Humans', 'Image Processing, Computer-Assisted', 'Ischemic Attack, Transient', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Middle Cerebral Artery', 'Motor Co... | 22,507,231 | [['M01.060.116'], ['M01.060.116.100'], ['G17.035', 'L01.224.050'], ['C10.228.140.300.150', 'C14.907.253.092'], ['C10.228.140.300.200.360', 'C14.907.137.230', 'C14.907.253.123.360'], ['G09.330.100.159'], ['G09.330.100.248'], ['G09.330.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['C10.228.140... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Finite element analysis of impact and shaking inflicted to a child. | This study compares a vigorous shaking and an inflicted impact, defined as the terminal portion of a vigorous shaking, using a finite element model of a 6-month-old child head. Whereas the calculated values in terms of shearing stress and brain pressure remain different and corroborate the previous studies based on ang... | ['Biomechanical Phenomena', 'Finite Element Analysis', 'Forensic Medicine', 'Head Injuries, Closed', 'Humans', 'Infant', 'Intracranial Pressure', 'Models, Biological', 'Shaken Baby Syndrome', 'Stress, Mechanical'] | 17,091,312 | [['G01.154.090', 'G01.374.089'], ['E05.355'], ['H02.403.330', 'I01.198.780.937'], ['C10.900.300.350', 'C26.915.300.450', 'C26.974.382'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['G11.561.170.505'], ['E05.599.395'], ['C10.900.300.087.850', 'C26.915.300.200.825'], ['G01.374.835']] | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 |
Spatiotemporal receptive fields of cells in V1 are optimally shaped for stimulus velocity estimation. | In recent literature, particularly interesting stimulus velocity-selective behaviors were found in the response properties of neurons belonging to the primary visual cortex (V1). In this work, 93 simple and complex cell receptive fields were obtained from the recordings of different experiments made on cats (DeAngelis,... | ['Animals', 'Cats', 'Fourier Analysis', 'Models, Biological', 'Neurons', 'Photic Stimulation', 'Time Factors', 'Uncertainty', 'Visual Cortex'] | 22,218,360 | [['B01.050'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['E05.377', 'G17.226', 'L01.224.800.625'], ['E05.599.395'], ['A08.675', 'A11.671'], ['E05.723.729'], ['G01.910.857'], ['E05.318.740.600.900', 'F02.463.785.373.820', 'G17.680.875', 'N05.715.360.750.625.850', 'N06.850.520.830.600.900'], ['A08.186.211.200.885.... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Combinatorial interaction of two adjacent cis-active promoter regions mediates the synergistic induction of Bt2 gene by sucrose and ABA in maize endosperm. | The accumulation of starch in cereal endosperm is a key process that determines crop yield and quality. Research has reported that sucrose and abscisic acid (ABA) synergistically regulate the synthesis of crop starch. However, little is known about the molecular mechanisms behind this synergistic effect. In this study,... | ['Abscisic Acid', 'Drug Synergism', 'Edible Grain', 'Endosperm', 'Gene Expression Regulation, Plant', 'Plant Growth Regulators', 'Plant Proteins', 'Promoter Regions, Genetic', 'Starch', 'Sucrose', 'Zea mays'] | 30,080,620 | [['D02.241.223.268.034', 'D02.455.326.271.665.202.061', 'D02.455.426.392.368.367.379.249.024', 'D02.455.849.131.061', 'D02.455.849.765.521.500'], ['G07.690.773.968.477'], ['A18.024.500.750.500', 'B01.650.160.250', 'B01.650.510.250', 'G07.203.300.300.550', 'G07.203.300.775.500', 'J02.500.300.550', 'J02.500.775.500'], ['... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Reversible hemichorea associated with extracranial carotid artery stenosis. | Hemichorea associated with carotid artery occlusive disease is extremely rare. It has been recently suggested that carotid artery stenosis should be considered in the differential diagnosis of chorea, even in the absence of a preceding stroke or transient ischemic attack. Although the pathophysiology of this condition ... | ['Aged, 80 and over', 'Carotid Artery, Internal', 'Carotid Stenosis', 'Cerebrovascular Circulation', 'Chorea', 'Humans', 'Magnetic Resonance Angiography', 'Magnetic Resonance Imaging', 'Male', 'Tomography, Emission-Computed, Single-Photon'] | 20,888,600 | [['M01.060.116.100.080'], ['A07.015.114.186.200.230'], ['C10.228.140.300.200.360', 'C14.907.137.230', 'C14.907.253.123.360'], ['G09.330.100.159'], ['C10.228.662.262.249', 'C10.597.350.250', 'C23.888.592.350.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500.500', 'E01.370.370.050.500'], ['E01... | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Reabsorption and secretion of alpha-ketoglutarate along the rat nephron: a micropuncture study. | The transport of alpha-ketoglutarate (alpha-KG) across the luminal membrane of the rat nephron was studied by micropuncture and microassay techniques. In normal and acidotic rats, approximately 75% of the filtered alpha-KG was reabsorbed in the proximal tubule and 20% in the pars recta and/or loop of Henle at endogenou... | ['Acid-Base Equilibrium', 'Acidosis', 'Alkalosis', 'Animals', 'Biological Transport, Active', 'Glomerular Filtration Rate', 'Ketoglutaric Acids', 'Kidney Tubules', 'Male', 'Nephrons', 'Punctures', 'Rats', 'Rats, Inbred Strains'] | 3,976,899 | [['G02.111.007', 'G02.300.176', 'G03.030', 'G07.410.110', 'G09.188.050'], ['C18.452.076.176'], ['C18.452.076.354'], ['B01.050'], ['G03.143.310'], ['E01.370.390.400.300', 'G08.852.357'], ['D02.241.081.337.351.502', 'D02.241.755.465'], ['A05.810.453.736.560'], ['A05.810.453.736'], ['E02.800', 'E04.665'], ['B01.050.150.90... | ['Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Phosphorus partitioning in sediments from a tropical reservoir during a strong period of drought. | Monitoring phosphorus (P) concentration in water and sediments in the Castanh?o reservoir, under intensive aquaculture, in Northeastern Brazil showed internal process to dominate P cycling following a reduction of reservoir volume due to an extended drought period. A strong negative correlation between soluble reactive... | ['Brazil', 'Climate Change', 'Droughts', 'Environmental Monitoring', 'Geologic Sediments', 'Phosphorus', 'Tropical Climate'] | 27,646,452 | [['Z01.107.757.176'], ['G16.500.175.374'], ['G16.500.175.781', 'G16.500.750.775.154', 'N06.230.100.230.150'], ['N06.850.460.350.080', 'N06.850.780.375'], ['G01.311.330', 'G16.500.320'], ['D01.268.666'], ['G16.500.275.071.600', 'N06.230.300.100.250.600']] | ['Geographicals [Z]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Correlations between scores on Chinese versions of long and short forms of the Geriatric Depression Scale among elderly Chinese. | A total of 187 elderly Chinese from the community were interviewed with the Chinese versions of the Geriatric Depression Scale-the long form and the short form. The scores on a proposed new version of the short form were also calculated. Cronbach alpha for the Geriatric Depression Scale-long form was .86. The correlati... | ['Aged', 'Aged, 80 and over', 'China', 'Depression', 'Female', 'Geriatric Assessment', 'Humans', 'Male', 'Psychiatric Status Rating Scales', 'Translating'] | 9,520,556 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['Z01.252.474.164'], ['F01.145.126.350'], ['E05.318.308.225', 'I01.240.425.350', 'N01.224.425.350', 'N05.715.360.300.360', 'N06.850.505.400.425.350', 'N06.850.520.308.225'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F04.711.513.653'], ['L01.559.423.796']] | ['Named Groups [M]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
The prevalence of antibody to human parvovirus B19 in pregnant women in Kuwait. | Infection with parvovirus B19 during pregnancy is known to be associated with various fetal damage, such as aplastic anemia and hydrops fetalis. Our objective was to study the seroprevalence of parvovirus B19 in the obstetric population in Kuwait and to compare this with that in the adult population in other regions. B... | ['Adult', 'Antibodies, Viral', 'Female', 'Humans', 'Immunoglobulin G', 'Immunoglobulin M', 'Kuwait', 'Parvoviridae Infections', 'Parvovirus B19, Human', 'Pregnancy', 'Pregnancy Complications, Infectious', 'Prospective Studies', 'Seroepidemiologic Studies'] | 10,546,839 | [['M01.060.116'], ['D12.776.124.486.485.114.254', 'D12.776.124.790.651.114.254', 'D12.776.377.715.548.114.254'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.124.486.485.114.619.393', 'D12.776.124.790.651.114.619.393', 'D12.776.377.715.548.114.619.393'], ['D12.776.124.486.485.114.619.574', 'D12.776.124.79... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Geographicals [Z]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
A conserved glutamate residue in the C-terminal deaminase domain of pentatricopeptide repeat proteins is required for RNA editing activity. | Many transcripts expressed from plant organelle genomes are modified by C-to-U RNA editing. Nuclear encoded pentatricopeptide repeat (PPR) proteins include an RNA binding domain that provides site specificity. In addition, many PPR proteins include a C-terminal DYW deaminase domain with characteristic zinc binding moti... | ['Agrobacterium', 'Amino Acid Motifs', 'Arabidopsis', 'Arabidopsis Proteins', 'Conserved Sequence', 'Cytidine Deaminase', 'Gene Expression Regulation, Plant', 'Glutamic Acid', 'Molecular Sequence Data', 'Protein Isoforms', 'Protein Structure, Tertiary', 'RNA Editing', 'RNA, Plant', 'Structure-Activity Relationship', 'T... | 25,739,442 | [['B03.440.400.425.700.024', 'B03.660.050.662.024'], ['G02.111.570.820.709.275.500', 'G02.111.570.820.709.600.500'], ['B01.650.940.800.575.912.250.157.100'], ['D12.776.765.149'], ['G02.111.570.580'], ['D08.811.277.151.486.250'], ['G05.308.375'], ['D12.125.067.625.349', 'D12.125.119.409.349', 'D12.125.427.300'], ['L01.4... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Information Science [L]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Free testosterone levels and implications on clinical outcomes in elderly men. | BACKGROUND AND AIMS: Aging is accompanied by a progressive decline in serum testosterone. Evidence concerning the clinical manifestations of low serum testosterone levels is contradictory. We aimed to examine the age-related decline in testosterone and the possible clinical outcomes, including erectile dysfunction, pro... | ['Aged', 'Erectile Dysfunction', 'Geriatrics', 'Humans', 'Male', 'Prognosis', 'Sexual Behavior', 'Testosterone'] | 18,594,186 | [['M01.060.116.100'], ['C12.294.644.486', 'F03.835.400'], ['H02.403.355'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.789'], ['F01.145.802'], ['D04.210.500.054.079.429.824', 'D06.472.334.851.968.984']] | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Expenditure Reductions Associated with a Social Service Referral Program. | Recent health system innovations provide encouraging evidence that greater coordination of medical and social services can improve health outcomes and reduce health care expenditures. This study evaluated the savings associated with a managed care organization's call center-based social service referral program that ai... | ['Adult', 'Aged', 'Cost Savings', 'Female', 'Health Care Costs', 'Humans', 'Male', 'Managed Care Programs', 'Medicaid', 'Medicare', 'Middle Aged', 'Population Health Management', 'Referral and Consultation', 'Social Determinants of Health', 'United States'] | 29,664,702 | [['M01.060.116'], ['M01.060.116.100'], ['N03.219.151.160.200'], ['N03.219.151.400', 'N05.300.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.219.521.576.343.800', 'N04.590.374.410'], ['N03.219.521.346.506.564.655', 'N03.706.615.693'], ['N03.219.521.346.506.564.663', 'N03.219.521.576.343.840', 'N03.706.615... | ['Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
[Value of the "startle" symptom in predicting the development of epileptic phenomena in infancy]. | This is the first description of the "startle reaction" observed in young children and of the technique of its stimulation. On the basis of the study of 38 children with the given symptom and of 30 control children aged up to 6 months the independence and pathologic nature of the startle reaction have been proved. 12-m... | ['Anticonvulsants', 'Epilepsy', 'Female', 'Humans', 'Infant', 'Infant, Newborn', 'Male', 'Nervous System Diseases', 'Reflex, Abnormal', 'Reflex, Startle'] | 3,630,489 | [['D27.505.954.427.080'], ['C10.228.140.490'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['C10'], ['C10.597.704', 'C23.888.592.717', 'E01.370.376.550.650.655', 'E01.370.600.550.650.655', 'G11.561.731.587'], ['E01.370.376.550.650.800', 'E01.370.600.550.650.800', 'F02.830.702.... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
MicroRNA regulation of endothelin-1 mRNA in renal collecting duct cells. | AIMS: Recently, microRNAs (miRNAs) have been implicated in control of Edn1 mRNA in several tissues. Here we examined the role of miRNA action on Edn1 mRNA expression in renal distal collecting duct cells.MAIN METHODS: A microarray study was conducted to provide a comprehensive assessment of miRNAs present in a murine i... | ["3' Untranslated Regions", 'Aldosterone', 'Animals', 'Argonaute Proteins', 'Binding Sites', 'Cell Line', 'Endothelin-1', 'Gene Expression Regulation', 'Immunoprecipitation', 'Kidney Tubules, Collecting', 'Mice', 'MicroRNAs', 'Oligonucleotide Array Sequence Analysis', 'RNA, Messenger', 'Reverse Transcriptase Polymerase... | 24,632,479 | [['D13.444.735.544.875.880', 'D13.444.735.790.878.880', 'G05.360.340.024.220.880.880', 'G05.360.340.024.340.137.910.880'], ['D04.210.500.745.745.654.062', 'D06.472.040.585.353.118'], ['B01.050'], ['D08.811.277.352.355.350.810.500', 'D08.811.277.352.700.350.810.500', 'D12.776.157.725.500.906.500', 'D12.776.664.962.500.9... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cost analysis of employing multi-test allergy screening to guide serial endpoint titration (SET) testing versus SET alone. | OBJECTIVE: We analyzed the cost differences between 2 different modalities of allergy testing. Study design and setting Material costs, labor costs, and overhead expenditures were compared for 2 different allergy-testing algorithms. Fifty patients were placed in each group. The first group was tested for 14 allergens a... | ['Algorithms', 'Costs and Cost Analysis', 'Humans', 'Hypersensitivity', 'Intradermal Tests', 'Mass Screening'] | 12,869,908 | [['G17.035', 'L01.224.050'], ['N03.219.151'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C20.543'], ['E01.370.225.812.871.300', 'E05.200.812.871.300', 'E05.478.594.890.300'], ['E01.370.500', 'E05.318.308.980.438.580', 'N02.421.726.233.443', 'N05.715.360.300.800.438.500', 'N06.850.520.308.980.438.580', 'N06.850.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
The metabolism of 1-hydroxy- and 2-hydroxy-3-methylcholanthrene by liver microsomes: effect of enzyme inducing agents. | The metabolism of both 1-hydroxy-3-methylcholanthrene (1-OH-3-MC) and 2-hydroxy-3-methylcholanthrene (2-OH-3-MC) by rat liver microsomes was investigated. Metabolites were separated by high pressure liquid chromatography (HPLC). Both compounds were shown to be substrates for further metabolism. Metabolism of 1-OH-3-MC ... | ['Animals', 'Aroclors', 'Enzyme Induction', 'Male', 'Methylcholanthrene', 'Microsomes, Liver', 'Phenobarbital', 'Rats'] | 6,498,793 | [['B01.050'], ['D02.309.750.500', 'D02.455.526.439.773.292', 'D02.455.526.439.785.292'], ['G05.308.320.200'], ['D02.455.426.559.847.149.500', 'D04.615.149.500'], ['A11.284.835.540.541'], ['D03.383.742.698.253.650'], ['B01.050.150.900.649.313.992.635.505.700']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Quantitative, real-time analysis of base excision repair activity in cell lysates utilizing lesion-specific molecular beacons. | We describe a method for the quantitative, real-time measurement of DNA glycosylase and AP endonuclease activities in cell nuclear lysates using base excision repair (BER) molecular beacons. The substrate (beacon) is comprised of a deoxyoligonucleotide containing a single base lesion with a 6-Carboxyfluorescein (6-FAM)... | ['DNA Glycosylases', 'DNA Repair', 'DNA-(Apurinic or Apyrimidinic Site) Lyase', 'Fluoresceins', 'Fluorescent Dyes', 'Oligonucleotide Probes', 'Real-Time Polymerase Chain Reaction'] | 22,895,410 | [['D08.811.074.249', 'D08.811.277.450.430.099'], ['G02.111.222', 'G05.219'], ['D08.811.074.750', 'D08.811.520.241.225'], ['D02.455.426.779.347', 'D03.633.300.953.275', 'D04.711.347'], ['D27.720.233.348', 'D27.720.470.410.505.500'], ['D13.444.600.601', 'D27.505.259.750.600.650', 'D27.720.470.530.600.650'], ['E05.393.620... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Prenatal diagnosis and management of a new autosomal recessive skeletal dysplasia. | We present a rare case of bilateral absence of fibula, hypoplastic femurs, ankylosis of knee joints and talipes equinovarus in a woman who had a previously affected offspring with similar defects. Antenatal diagnosis, management and a short review of the literature are presented. | ['Abnormalities, Multiple', 'Abortion, Induced', 'Adult', 'Ankylosis', 'Bone Diseases, Developmental', 'Clubfoot', 'Female', 'Femur', 'Fibula', 'Genes, Recessive', 'Humans', 'Knee Joint', 'Pregnancy', 'Pregnancy Trimester, Second', 'Ultrasonography, Prenatal'] | 9,457,984 | [['C16.131.077'], ['E04.520.050'], ['M01.060.116'], ['C05.550.069'], ['C05.116.099'], ['C05.330.488.655.063', 'C05.330.495.681.063', 'C05.660.585.512.380.813.063', 'C16.131.621.585.512.500.681.063'], ['A02.835.232.043.150'], ['A02.835.232.043.650.321'], ['G05.360.340.024.340.415', 'G05.420.325'], ['B01.050.150.900.649.... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Predictive validity and efficiency of ongoing visual-inspection criteria for interpreting functional analyses. | Prior research has evaluated the reliability and validity of structured criteria for visually inspecting functional-analysis (FA) results on a post-hoc basis, after completion of the FA (i.e., post-hoc visual inspection [PHVI]; e.g., Hagopian et al., 1997). However, most behavior analysts inspect FAs using ongoing visu... | ['Behavior Observation Techniques', 'Data Analysis', 'Data Visualization', 'Humans', 'Problem Behavior', 'Reproducibility of Results'] | 29,527,741 | [['E05.796.112', 'F04.669.112'], ['H01.548.338'], ['L01.143.288'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.126.972', 'F01.145.179.750'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Disciplines and Occupations [H]', 'Information Science [L]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Vaporization-condensation-recrystallization process-mediated synthesis of helical m-aminobenzoic acid nanobelts. | One-dimensional (1D) helical organic nanostructures were synthesized by a modified vapor-solid (VS) process, called the vaporization-condensation-recrystallization (VCR) process. The conventional solution-phase synthetic methods generally mediate self-assemblies of repeating unit molecules. To provide enough intermolec... | ['Algorithms', 'Aminobenzoates', 'Crystallization', 'Dimerization', 'Microscopy, Electron, Transmission', 'Models, Theoretical', 'Molecular Structure', 'Nanostructures', 'Scattering, Small Angle', 'Surface Properties', 'Temperature', 'Volatilization', 'X-Ray Diffraction', 'meta-Aminobenzoates'] | 17,918,873 | [['G17.035', 'L01.224.050'], ['D02.241.223.100.050', 'D02.455.426.559.389.127.020'], ['E05.196.300', 'G02.171'], ['G02.206', 'G03.230'], ['E01.370.350.515.402.580', 'E05.595.402.580'], ['E05.599'], ['G02.111.570', 'G02.466'], ['J01.637.512'], ['E05.196.822.830', 'G01.867.755'], ['G02.860'], ['G01.906.595', 'G16.500.275... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 |
Histological and ultrastructural study of Zona Radiata in oocyte of common carp Cyprinus carpio (Linnaeus 1758). | Oocytes and fertilized eggs of teleosts are enclosed by a non-cellular envelope, the Zona Radiata (ZR). It has structural differences in various ecological and systematic groups of fish. Ultrastructural analysis has shown that ZR is formed during the previtellogenic stages. Morphological characteristics of ZR suggest v... | ['Animals', 'Carps', 'Female', 'Histocytochemistry', 'Microscopy', 'Microscopy, Electron, Scanning', 'Oocytes', 'Ovary'] | 20,605,473 | [['B01.050'], ['B01.050.150.900.493.200.244.248'], ['E01.370.225.500.607', 'E01.370.225.750.551', 'E05.200.500.607', 'E05.200.750.551', 'H01.158.100.656.234', 'H01.158.201.344', 'H01.181.122.573'], ['E01.370.350.515', 'E05.595', 'H01.671.617.562'], ['E01.370.350.515.402.541', 'E05.595.402.541'], ['A05.360.490.690.680',... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Tridecanoin is anticonvulsant, antioxidant, and improves mitochondrial function. | The hypothesis that chronic feeding of the triglycerides of octanoate (trioctanoin) and decanoate (tridecanoin) in "a regular non-ketogenic diet" is anticonvulsant was tested and possible mechanisms of actions were subsequently investigated. Chronic feeding of 35E% of calories from tridecanoin, but not trioctanoin, was... | ['3-Hydroxybutyric Acid', 'Animals', 'Anticonvulsants', 'Antioxidants', 'Blood Glucose', 'Brain', 'Decanoates', 'Disease Models, Animal', 'Male', 'Mice, Inbred Strains', 'Mitochondria', 'Seizures', 'Triglycerides'] | 27,418,037 | [['D02.241.081.114.937.349', 'D02.241.511.429.349', 'D02.522.585.087', 'D10.251.400.143.781.500'], ['B01.050'], ['D27.505.954.427.080'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['D09.947.875.359.448.500'], ['A08.186.211'], ['D10.251.175.200'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['B01.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Intraocular lens implantation in children with unilateral congenital cataract in the first 4 years of life. | PURPOSE: To describe the outcome of phacoaspiration with intraocular lens implantation in children with unilateral congenital cataract in the first 4 years of life.METHODS: A retrospective chart review of children with visually significant unilateral congenital cataract presenting in the first 4 years of life was done.... | ['Cataract', 'Cataract Extraction', 'Child, Preschool', 'Female', 'Follow-Up Studies', 'Humans', 'Infant', 'Lens Implantation, Intraocular', 'Lenses, Intraocular', 'Male', 'Postoperative Complications', 'Pseudophakia', 'Retrospective Studies', 'Treatment Outcome', 'Visual Acuity'] | 30,060,694 | [['C11.510.245'], ['E04.540.825.249'], ['M01.060.406.448'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['E04.540.825.600'], ['E07.632.500.460', 'E07.695.460'], ['C23.550.767'], ['C23.888.681'], ['E05.318.37... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
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