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[Expression of HPV16 L1 protein in insect cell suspension culture system]. | OBJECTIVE: To express the L1 protein of human papillomavirus type 16 (HPV16) in insect cell suspension culture system.METHODS: Optimized the conditions of suspension culture, recombinant virus amplification and protein expression. Determined the virus tilter by plague analysis and detected the target protein by SDS-PAG... | ['Animals', 'Capsid Proteins', 'Cell Proliferation', 'Oncogene Proteins, Viral', 'Recombinant Proteins', 'Spodoptera', 'Suspensions', 'Virion'] | 18,322,600 | [['B01.050'], ['D12.776.964.970.600.550'], ['G04.161.750', 'G07.345.249.410.750'], ['D12.776.624.664.520', 'D12.776.964.700'], ['D12.776.828'], ['B01.050.500.131.617.720.500.500.937.650.700'], ['D20.280.810', 'D26.255.165.810'], ['A21.249']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Concomitant degradation of beta-catenin and GSK-3 beta potently contributes to glutamate-induced neurotoxicity in rat hippocampal slice cultures. | Increasingly, published evidence links glutamate with the pathogenesis of Alzheimer's disease. We investigated the molecular mechanism underlying glutamate-induced neurotoxicity in hippocampus, which is primarily linked to cognitive dysfunction in Alzheimer's disease. Acute exposure of rat hippocampal slices to glutama... | ['Animals', 'Cell Death', 'Dose-Response Relationship, Drug', 'Glutamic Acid', 'Glycogen Synthase Kinase 3', 'Glycogen Synthase Kinase 3 beta', 'Hippocampus', 'Organ Culture Techniques', 'Rats', 'Rats, Sprague-Dawley', 'beta Catenin'] | 18,445,133 | [['B01.050'], ['G04.146'], ['G07.690.773.875', 'G07.690.936.500'], ['D12.125.067.625.349', 'D12.125.119.409.349', 'D12.125.427.300'], ['D05.500.117.875', 'D08.811.913.696.620.682.700.429.500', 'D08.811.913.696.620.682.700.646.625', 'D12.644.360.300.500', 'D12.776.476.081.875', 'D12.776.476.300.500'], ['D05.500.117.875.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Localized mucinous bronchioloalveolar carcinoma of the lung: thin-section computed tomography and fluorodeoxyglucose positron emission tomography findings. | PURPOSE: The aim of this study was to evaluate thinsection computed tomography (CT) and fluorodeoxyglucose positron emission tomography (FDG-PET) findings of localized pulmonary mucinous bronchioloalveolar carcinomas (BACs).METHODS AND MATERIALS: From February 2000 to February 2009, there were seven patients with pulmo... | ['Adenocarcinoma, Bronchiolo-Alveolar', 'Adenocarcinoma, Mucinous', 'Adult', 'Aged', 'Female', 'Fluorodeoxyglucose F18', 'Goblet Cells', 'Humans', 'Lung Neoplasms', 'Male', 'Middle Aged', 'Positron-Emission Tomography', 'Radiopharmaceuticals', 'Tomography, X-Ray Computed'] | 20,512,541 | [['C04.557.470.200.025.022.500', 'C04.588.894.797.520.055.500'], ['C04.557.470.200.025.075', 'C04.557.470.590.075'], ['M01.060.116'], ['M01.060.116.100'], ['D09.254.229.500'], ['A03.556.124.369.320', 'A04.329.597.320', 'A04.531.520.320', 'A04.760.259', 'A10.615.550.444.321', 'A10.615.550.760.520.320', 'A10.615.550.760.... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Experiences of self-care in patients with colorectal cancer: a longitudinal study. | AIM: This paper is a report of a study to explore patients' experiences of self-care during a 6-month course of chemotherapy treatment for colorectal cancer.BACKGROUND: A greater degree of patient involvement in self-care is increasingly being encouraged, however, little is known about patients' experiences of being ac... | ['Aged', 'Colorectal Neoplasms', 'Female', 'Humans', 'Longitudinal Studies', 'Male', 'Middle Aged', "Nurse's Role", 'Patient Education as Topic', 'Patient Satisfaction', 'Self Care', 'Self Concept', 'Time Factors'] | 18,764,852 | [['M01.060.116.100'], ['C04.588.274.476.411.307', 'C06.301.371.411.307', 'C06.405.249.411.307', 'C06.405.469.158.356', 'C06.405.469.491.307', 'C06.405.469.860.180'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.500.750.500', 'N05.715.360.330.500.750.500', 'N06.850.520.450.500.750.500'], ['M01.060.116.... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Structural stigma and cigarette smoking in a prospective cohort study of sexual minority and heterosexual youth. | BACKGROUND: Sexual minority youth are more likely to smoke cigarettes than heterosexuals, but research into the determinants of these disparities is lacking.PURPOSE: This study aimed to examine whether exposure to structural stigma predicts cigarette smoking in sexual minority youth.METHODS: Prospective data from adole... | ['Adolescent', 'Female', 'Humans', 'Longitudinal Studies', 'Male', 'Minority Groups', 'Prospective Studies', 'Risk Factors', 'Sexuality', 'Smoking', 'Social Stigma', 'Young Adult'] | 24,136,092 | [['M01.060.057'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.500.750.500', 'N05.715.360.330.500.750.500', 'N06.850.520.450.500.750.500'], ['I01.880.853.300'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['E05.318.740.600.800.725', 'N05.715.350.200.700',... | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Brain and ventricular volumetric changes in frontotemporal lobar degeneration over 1 year. | BACKGROUND: Measurement of volumetric changes with MR might be a useful surrogate endpoint for clinical trials in frontotemporal lobar degeneration (FTLD). Because there is only limited longitudinal imaging data currently available, we measured the rate of change over 1 year of whole brain volume (WBV) and ventricular ... | ['Aged', 'Algorithms', 'Aphasia', 'Aphasia, Primary Progressive', 'Brain', 'Cerebral Ventricles', 'Clinical Trials as Topic', 'Dementia', 'Female', 'Follow-Up Studies', 'Humans', 'Linear Models', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Organ Size', 'Severity of Illness Index'] | 19,470,967 | [['M01.060.116.100'], ['G17.035', 'L01.224.050'], ['C10.597.606.150.500.800.100', 'C23.888.592.604.150.500.800.100'], ['C10.228.140.380.132', 'C10.597.606.150.500.800.100.155', 'C23.888.592.604.150.500.800.100.155', 'F03.615.400.125'], ['A08.186.211'], ['A08.186.211.140'], ['E05.318.372.250.250', 'N05.715.360.330.250.2... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Outcomes of a standardized triple-drug regimen for the treatment of nontuberculous mycobacterial pulmonary infection. | The treatment of fibrocavitatory pulmonary infection due to Mycobacterium avium complex and Mycobacterium malmoense poses a challenge. This study assessed microbial, inflammatory, radiographic, and clinical outcomes for a standardized 24-month triple-drug regime. Following treatment completion, all patients had fewer s... | ['Aged', 'Anti-Bacterial Agents', 'Blood Sedimentation', 'Ciprofloxacin', 'Clarithromycin', 'Drug Resistance, Bacterial', 'Drug Therapy, Combination', 'Ethambutol', 'Female', 'Humans', 'Lung', 'Male', 'Microbial Sensitivity Tests', 'Middle Aged', 'Mycobacterium Infections, Nontuberculous', 'Mycobacterium avium', 'Mycob... | 18,532,890 | [['M01.060.116.100'], ['D27.505.954.122.085'], ['E01.370.225.625.125', 'E05.200.625.125'], ['D03.633.100.810.835.322.186'], ['D02.540.576.500.992.100'], ['G06.099.225', 'G06.225.347', 'G07.690.773.984.269.347'], ['E02.319.310'], ['D02.092.782.258.368.265'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A04.411'], ... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Discrimination of EMG and acceleration measurements between patients with Parkinson's disease and healthy persons. | In this paper, we examine the potential of electromyographic (EMG) and acceleration measurements in discriminating patients with Parkinson's disease (PD) from healthy persons. Two types of muscle contractions are examined: static contractions of biceps brachii muscles and elbow extension movements. Twelve features are ... | ['Acceleration', 'Algorithms', 'Diagnosis, Computer-Assisted', 'Diagnosis, Differential', 'Discriminant Analysis', 'Electromyography', 'Humans', 'Muscle, Skeletal', 'Parkinson Disease', 'Physical Examination', 'Reproducibility of Results', 'Sensitivity and Specificity'] | 21,096,652 | [['G01.482.107'], ['G17.035', 'L01.224.050'], ['E01.158', 'L01.313.500.750.100.158'], ['E01.171'], ['E05.318.740.350', 'N05.715.360.750.325', 'N06.850.520.830.350'], ['E01.370.405.255', 'E01.370.530.255'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.633.567', 'A10.690.552.500'], ['C10.228.140.079.862.500', '... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Control of peripheral benzodiazepine receptor-mediated breast cancer in rats by soy protein. | Soy protein is known to have breast tumor suppressing activity. The expression of peripheral benzodiazepine receptors (PBRs), currently renamed as translocator protein (TSPO) and their associated functions, such as nuclear cholesterol uptake and content also have been shown to be increased in breast cancer. Here we inv... | ['9,10-Dimethyl-1,2-benzanthracene', 'Animals', 'Benzodiazepinones', 'Carcinogens', 'Female', 'Ligands', 'Mammary Neoplasms, Experimental', 'Protein Binding', 'Rats', 'Rats, Sprague-Dawley', 'Receptors, GABA-A', 'Soybean Proteins', 'Tritium'] | 17,932,947 | [['D02.455.426.559.847.149.301', 'D04.615.149.301'], ['B01.050'], ['D03.633.100.079.080.070'], ['D27.888.569.100'], ['D27.720.470.480'], ['C04.588.531.500', 'C04.619.590', 'E05.598.500.496.843'], ['G02.111.679', 'G03.808'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.750'], ['... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Synergistic interactions of combinations of topotecan with standard drugs in primary cultures of human tumor cells from patients. | OBJECTIVE: Combination therapies are important in the treatment of many tumor types. This study was undertaken to find candidates for combination therapy with the novel topoisomerase I inhibitor topotecan.METHODS: The cytotoxic effect of topotecan alone and in combination with five standard cytotoxic drugs was studied ... | ['Antineoplastic Combined Chemotherapy Protocols', 'Cisplatin', 'Doxorubicin', 'Drug Screening Assays, Antitumor', 'Drug Synergism', 'Enzyme Inhibitors', 'Humans', 'Neoplasms', 'Topoisomerase I Inhibitors', 'Topotecan', 'Tumor Cells, Cultured'] | 9,832,291 | [['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['D01.210.375', 'D01.625.125', 'D01.710.100'], ['D02.455.426.559.847.562.050.200.175', 'D04.615.562.050.200.175', 'D09.408.051.059.200.175'], ['E01.370.225.500.388', 'E05.200.500.388', 'E05.242.417', 'E05.337.550.200'], ['G07.690.773.968.477'], ['D27.505.519.3... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Survey of the diet of Pima Indians using quantitative food frequency assessment and 24-hour recall. Diabetic Renal Disease Study. | OBJECTIVE: A dietary survey was conducted in the Gila River Indian Community in Arizona using two methods of dietary assessment--24-hour recall and quantitative food frequency (QFF) assessment--to determine the usual intake of the population.DESIGN: Interviews were conducted by Pima women who were trained and monitored... | ['Adolescent', 'Adult', 'Aged', 'Anthropometry', 'Arizona', 'Diet', 'Diet Records', 'Diet Surveys', 'Energy Intake', 'Feeding Behavior', 'Female', 'Humans', 'Indians, North American', 'Interviews as Topic', 'Male', 'Microcomputers', 'Middle Aged', 'Reproducibility of Results', 'Sex Factors'] | 8,683,009 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['E01.370.600.024', 'E05.041', 'N06.850.505.200.100'], ['Z01.107.567.875.760.100'], ['G07.203.650.240'], ['N04.452.859.360'], ['E05.318.308.980.485.350', 'N05.715.360.300.800.469.300', 'N06.850.505.616.300', 'N06.850.520.308.980.469.350'], ['G07.203.650.240.340'],... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
Histology of connective tissue graft. A case report. | BACKGROUND: Few investigations can be found in the literature on the histological nature of the attachment of connective tissue grafts to root surfaces previously exposed by recession.METHODS: In this case report, a 24-year-old patient was treated with a connective tissue graft combined with a partial-thickness coronal... | ['Adult', 'Alveolar Process', 'Bicuspid', 'Bone Remodeling', 'Coloring Agents', 'Connective Tissue', 'Dental Cementum', 'Epithelial Attachment', 'Female', 'Fluorescent Dyes', 'Follow-Up Studies', 'Gingiva', 'Gingival Recession', 'Humans', 'Serial Extraction', 'Surgical Flaps', 'Tooth Cervix', 'Tooth Root', 'Wound Heali... | 11,759,874 | [['M01.060.116'], ['A02.835.232.781.324.502.125', 'A14.521.125', 'A14.549.167.646.094'], ['A14.549.167.860.150'], ['G11.427.213', 'G16.762.150'], ['D27.720.233'], ['A10.165'], ['A14.549.167.646.267', 'A14.549.167.900.250'], ['A14.549.167.646.374'], ['D27.720.233.348', 'D27.720.470.410.505.500'], ['E05.318.372.500.750.2... | ['Named Groups [M]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
MiR-223 is dispensable for platelet production and function in mice. | MicroRNAs (miRNAs) are key physiological regulators in multiple cell types. Here, we assessed platelet production and function in mice deficient in miR-223, one of the most abundantly expressed miRNAs in platelets and megakaryocytes. We found platelet number, size, life-span as well as surface expression of platelet ad... | ['Animals', 'Antibody-Dependent Cell Cytotoxicity', 'Bleeding Time', 'Blood Coagulation', 'Blood Platelets', 'Bone Marrow Transplantation', 'Cell Adhesion Molecules', 'Cell Count', 'Cells, Cultured', 'Humans', 'Megakaryocytes', 'Mice', 'Mice, Inbred Strains', 'Mice, Knockout', 'MicroRNAs', 'Platelet Activation', 'Throm... | 24,067,995 | [['B01.050'], ['G12.287.070'], ['E01.370.225.625.625.100', 'E05.200.625.625.100', 'G09.188.087'], ['G09.188.390.150'], ['A11.118.188', 'A15.145.229.188'], ['E02.095.147.725.040', 'E04.936.580.040'], ['D12.776.395.550.200', 'D12.776.543.550.200', 'D23.050.301.350'], ['E01.370.225.500.195', 'E05.200.500.195', 'E05.242.19... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mechanical properties of the copper-deficient rat heart. | Copper deficiency is known to induce cardiac hypertrophy, cardiac morphologic lesions and altered electrocardiograms. These findings suggest that copper deficiency may also influence the mechanical properties of the myocardium. In the present study, weanling albino rats were fed a copper-deficient (-Cu) diet and compar... | ['Animals', 'Cardiomegaly', 'Copper', 'Growth', 'Heart', 'Heart Rate', 'Male', 'Myocardium', 'Norepinephrine', 'Oxygen Consumption', 'Rats', 'Rats, Inbred Strains', 'Systole'] | 6,215,471 | [['B01.050'], ['C14.280.195', 'C23.300.775.250'], ['D01.268.556.195', 'D01.268.956.170', 'D01.552.544.195'], ['G07.345.249'], ['A07.541'], ['E01.370.600.875.500', 'G09.330.380.500'], ['A02.633.580', 'A07.541.704', 'A10.690.552.750'], ['D02.033.100.291.502', 'D02.092.063.480', 'D02.092.211.215.746', 'D02.092.311.830', '... | ['Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The effect of the color red on consuming food does not depend on achromatic (Michelson) contrast and extends to rubbing cream on the skin. | Recent literature suggests that individuals may consume less food when this is served on red plates. We explored this intriguing effect in three experiments. Independent groups of participants were presented with constant amounts of popcorns, chocolate chips, or moisturizing cream, on red, blue, or white plates. They w... | ['Adult', 'Aged', 'Color', 'Eating', 'Female', 'Food Preferences', 'Humans', 'Linear Models', 'Male', 'Middle Aged', 'Surveys and Questionnaires', 'Taste', 'Young Adult'] | 23,999,521 | [['M01.060.116'], ['M01.060.116.100'], ['G01.590.540.199'], ['G07.203.650.283', 'G10.261.330'], ['F01.145.407.516', 'G07.203.650.353.516'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.500', 'E05.318.740.750.425', 'E05.599.835.750', 'N05.715.360.750.530.460', 'N05.715.360.750.695.460', 'N06.850.52... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Effects of simulated elevation of atmospheric CO2 concentration on the physiological features of spring phytoplankton in Taihu Lake]. | To disclose the impact of different CO2 concentrations (270 x 10(-6), 380 x 10(-6), 750 x 10(-6)) on physiological features of spring phytoplankton, an in situ simulated experiment was carried out in Meiliang Bay of Taihu Lake from 29 April to 26 May in 2012. The results showed that atmospheric CO2 elevation would sign... | ['Atmosphere', 'Carbon Dioxide', 'Carbonates', 'China', 'Chlorophyta', 'Computer Simulation', 'Diatoms', 'Ecosystem', 'Fresh Water', 'Lakes', 'Phytoplankton', 'Seasons'] | 23,947,023 | [['G16.500.275.063', 'N06.230.300.100'], ['D01.200.200', 'D01.362.150', 'D01.650.550.200'], ['D01.045.125', 'D01.200.275.150', 'D01.248.497.158.165'], ['Z01.252.474.164'], ['B01.650.940.150'], ['L01.224.160'], ['B01.750.200'], ['G16.500.275.157', 'N06.230.124'], ['G16.500.275.280', 'N06.230.232'], ['G01.311.580', 'G16.... | ['Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Organisms [B]', 'Information Science [L]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 |
Promoting Factors for Physical Activity in Children with Asthma Explored through Concept Mapping. | For children with asthma, physical activity (PA) can decrease the impact of their asthma. Thus far, effective PA promoting interventions for this group are lacking. To develop an intervention, the current study aimed to identify perspectives on physical activity of children with asthma, their parents, and healthcare pr... | ['Asthma', 'Child', 'Cluster Analysis', 'Disabled Persons', 'Exercise', 'Female', 'Health Personnel', 'Health Promotion', 'Humans', 'Male', 'Parents'] | 31,766,299 | [['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['M01.060.406'], ['E05.318.740.250', 'N05.715.360.750.200', 'N06.850.520.830.250'], ['M01.150'], ['G11.427.410.698.277', 'I03.350'], ['M01.526.485', 'N02.360'], ['I02.233.332.445', 'N02.421.726.407.579'], ['B01.050.150.900.649.313.988.400.112.40... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Identification of mesothelioma-specific sialylated epitope recognized with monoclonal antibody SKM9-2 in a mucin-like membrane protein HEG1. | The anti-mesothelioma mAb SKM9-2 recognizes the sialylated protein HEG homolog 1 (HEG1). HEG1 is a 400 kDa mucin-like membrane protein found on mesothelioma. SKM9-2 can detect mesothelioma more specifically and sensitively than other antibodies against current mesothelioma markers; therefore, SKM9-2 would be likely use... | ['Antibodies, Monoclonal', 'Cell Line, Tumor', 'Enzyme-Linked Immunosorbent Assay', 'Epitopes', 'Glycosylation', 'Humans', 'Lectins', 'Lung Neoplasms', 'Mass Spectrometry', 'Membrane Proteins', 'Mesothelioma', 'Mesothelioma, Malignant', 'N-Acetylneuraminic Acid', 'Peptides', 'Polysaccharides', 'Protein Binding'] | 30,250,045 | [['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['A11.251.210.190', 'A11.251.860.180'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['D23.050.550'], ['G02.111.158.812', 'G02.607.299', 'G03.191.812'],... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The bioavailability of apigenin-7-glucoside is influenced by human intestinal microbiota in rats. | We investigated the impact of human intestinal microbiota on bioavailability of the flavone apigenin-7-glucoside (A7G) by comparing germ-free and human microbiota-associated (HMA) rats. First, the ability of the human intestinal microbiota to convert A7G was proven in vitro by incubating A7G with fecal suspensions. Api... | ['Adult', 'Animals', 'Apigenin', 'Bacteria', 'Biological Availability', 'Feces', 'Female', 'Germ-Free Life', 'Humans', 'Intestines', 'Male', 'Middle Aged', 'Rats', 'Species Specificity', 'Young Adult'] | 19,403,720 | [['M01.060.116'], ['B01.050'], ['D03.383.663.283.266.450.260.110', 'D03.633.100.150.266.450.260.110'], ['B03'], ['G03.787.151', 'G07.690.725.129'], ['A12.459'], ['G06.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A03.556.124'], ['M01.060.116.630'], ['B01.050.150.900.649.313.992.635.505.700'], ['G16.824'], [... | ['Named Groups [M]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Role of oral contraceptive agents in the pathogenesis of liver tumors. | Since the introduction of oral contraceptive steroids in 1960 there has been a sharp increase in the incidence of benign liver tumors. Epidemiologic and other evidence links focal nodular hyperplasia and hepatic cell adenoma to the use of these agents. The risk increases with long-term exposure. The majority of patient... | ['Adult', 'Animals', 'Carcinoma, Hepatocellular', 'Contraceptives, Oral', 'Ethinyl Estradiol', 'Female', 'Hamartoma', 'Humans', 'Hyperplasia', 'Liver', 'Liver Neoplasms', 'Male', 'Mestranol', 'Neoplasms, Experimental', 'Pregnancy', 'Pregnancy Complications', 'Rats', 'Rupture, Spontaneous'] | 224,197 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Building better fibrin knob mimics: an investigation of synthetic fibrin knob peptide structures in solution and their dynamic binding with fibrinogen/fibrin holes. | Fibrin polymerizes via noncovalent and dynamic association of thrombin-exposed "knobs" with complementary "holes." Synthetic knob peptides have received significant interest as a means for understanding fibrin assembly mechanisms and inhibiting fibrin polymerization. Nevertheless, the inability to crystallize short pep... | ['Biomimetics', 'Fibrin', 'Fibrinogen', 'Humans', 'Models, Molecular', 'Molecular Dynamics Simulation', 'Peptide Fragments', 'Protein Binding', 'Protein Conformation', 'Solutions', 'Surface Plasmon Resonance', 'Thrombin'] | 20,484,082 | [['H01.158.550.100', 'J01.897.120.100'], ['D12.776.124.270'], ['D12.776.124.050.250', 'D12.776.124.125.500', 'D12.776.811.300', 'D23.119.490'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.595'], ['E05.599.595.500', 'G02.111.570.895', 'L01.224.160.500'], ['D12.644.541'], ['G02.111.679', 'G03.808'], ['G02.... | ['Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Information Science [L]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 |
Plateletpheresis during plasma collection. | New systems for collection of platelet concentrate (PC) and platelet poor plasma (PPP) are presently available. The aim of our work was to test the possibility of preparing PC routinely from normal plasma donors in a minimum amount of time and, at the same time, providing a second product that can be used as source-pla... | ['Humans', 'Plasmapheresis', 'Platelet Count', 'Platelet Transfusion', 'Plateletpheresis'] | 8,013,973 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.120.770', 'E02.912.715', 'E04.292.869'], ['E01.370.225.500.195.107.740', 'E01.370.225.625.107.700', 'E01.370.225.625.625.625', 'E05.200.500.195.107.740', 'E05.200.625.107.700', 'E05.200.625.625.625', 'E05.242.195.107.740', 'G04.140.107.740', 'G09.188.105.700'], ['... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Record keeping in two types of relationships. | On the basis of a distinction between communal and exchange relationships (Clark & Mills, 1979; Mills & Clark, 1982), the following predictions were made: (a) Members of exchange relationships would keep track of individual inputs into joint tasks and (b) members of communal relationships would not. These hypotheses we... | ['Adult', 'Female', 'Humans', 'Interpersonal Relations', 'Male', 'Psychological Theory', 'Set, Psychology', 'Social Behavior'] | 6,491,869 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.401'], ['F02.739'], ['F02.463.425.838'], ['F01.145.813']] | ['Named Groups [M]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Matching physician practice style to patient informational issues and decision-making preferences. An approach to patient autonomy and medical paternalism issues in clinical practice. | The movement away from traditional medical paternalism toward increased patient autonomy presents difficult practical and ethical problems for the physician treating the wide variety of patients seen in clinical practice. A review of the literature supports the concept of matching the physician's practice style with bo... | ['Comprehension', 'Decision Making', 'Disclosure', 'Humans', 'Models, Psychological', 'Paternalism', 'Patient Participation', 'Personal Autonomy', 'Physician-Patient Relations'] | 7,987,509 | [['F02.463.188.357'], ['F02.463.785.373'], ['F01.829.401.046', 'I01.880.604.583.080.134', 'L01.143.335'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.695'], ['F01.829.547'], ['F01.100.150.750.500.620', 'F01.145.488.887.500.620', 'N02.421.143.212.300', 'N03.540.245.360.300', 'N05.300.150.800.500.620'], ['... | ['Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Humanities [K]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 |
Sustained c-Jun-NH2-kinase activity promotes epithelial-mesenchymal transition, invasion, and survival of breast cancer cells by regulating extracellular signal-regulated kinase activation. | The c-Jun NH(2)-terminus kinase (JNK) mediates stress-induced apoptosis and the cytotoxic effect of anticancer therapies. Paradoxically, recent clinical studies indicate that elevated JNK activity in human breast cancer is associated with poor prognosis. Here, we show that overexpression of a constitutively active JNK ... | ['Animals', 'Antineoplastic Agents', 'Breast Neoplasms', 'Carcinoma', 'Cell Dedifferentiation', 'Cell Lineage', 'Cell Movement', 'Cell Survival', 'Cell Transformation, Neoplastic', 'Enzyme Activation', 'Epithelial Cells', 'Extracellular Signal-Regulated MAP Kinases', 'Female', 'Humans', 'Insulin Receptor Substrate Prot... | 20,145,041 | [['B01.050'], ['D27.505.954.248'], ['C04.588.180', 'C17.800.090.500'], ['C04.557.470.200'], ['G04.148'], ['G04.172', 'G07.345.500.325.180.500', 'G08.686.155', 'G08.686.784.170.104.249'], ['G04.198', 'G07.568.500.180'], ['G04.346'], ['C04.697.098.500', 'C23.550.727.098.500'], ['G02.111.263', 'G03.328'], ['A11.436'], ['D... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Increased apoptosis of immunoreactive host cells and augmented donor leukocyte chimerism, not sustained inhibition of B7 molecule expression are associated with prolonged cardiac allograft survival in mice preconditioned with immature donor dendritic cells plus anti-CD40L mAb. | BACKGROUND: We previously reported the association among donor leukocyte chimerism, apoptosis of presumedly IL-2-deficient graft-infiltrating host cells, and the spontaneous donor-specific tolerance induced by liver but not heart allografts in mice. Survival of the rejection-prone heart allografts in the same strain co... | ['Animals', 'Antibodies, Monoclonal', 'Antigens, CD', 'Antigens, Differentiation, T-Lymphocyte', 'Apoptosis', 'B7-2 Antigen', 'Bone Marrow Cells', 'CD40 Ligand', 'Dendritic Cells', 'Graft Survival', 'Granulocyte-Macrophage Colony-Stimulating Factor', 'Heart Transplantation', 'Immunophenotyping', 'Interleukin-4', 'Leuko... | 10,515,374 | [['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D23.050.301.264.035', 'D23.101.100.110'], ['D23.050.301.264.894', 'D23.101.100.894'], ['G04.146.954.035'], ['D12.776.465.500', 'D12.776.467.150.200', 'D12.776.543.095.200', 'D23.050.301.285.200', 'D23.529.168.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
TGFâ and PDGF-B signaling blockade inhibits myofibroblast development from both bone marrow-derived and keratocyte-derived precursor cells in vivo. | Myofibroblasts, the primary cells associated with corneal stromal haze (opacity), can be derived from both cornea-derived and bone marrow-derived precursor cells. In the present study, the role of TGFâ or PDGF blockage on bone marrow-derived myofibroblast development was investigated using a green fluorescent protein (... | ['Actins', 'Animals', 'Bone Marrow Cells', 'Corneal Keratocytes', 'Female', 'Fluorescent Antibody Technique, Indirect', 'Genetic Vectors', 'Green Fluorescent Proteins', 'Mice', 'Mice, Inbred C57BL', 'Myofibroblasts', 'Photorefractive Keratectomy', 'Plasmids', 'Proto-Oncogene Proteins c-sis', 'Signal Transduction', 'Ste... | 24,582,892 | [['D05.750.078.730.250', 'D12.776.210.500.100', 'D12.776.220.525.255'], ['B01.050'], ['A11.148', 'A15.378.316'], ['A11.329.228.109'], ['E01.370.225.500.607.512.240.310', 'E01.370.225.750.551.512.240.310', 'E05.200.500.607.512.240.310', 'E05.200.750.551.512.240.310', 'E05.478.583.375.310'], ['G05.360.337'], ['D12.776.53... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases. | Microglia play critical roles in brain development, homeostasis, and neurological disorders. Here, we report that human microglial-like cells (iMGLs) can be differentiated from iPSCs to study their function in neurological diseases, like Alzheimer's disease (AD). We find that iMGLs develop in vitro similarly to microgl... | ['Alzheimer Disease', 'Amyloid beta-Peptides', 'Amyloid beta-Protein Precursor', 'Animals', 'Brain', 'Cells, Cultured', 'Cytokines', 'Disease Models, Animal', 'Humans', 'Induced Pluripotent Stem Cells', 'Mice', 'Microglia', 'Peptide Fragments'] | 28,426,964 | [['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['D12.644.024', 'D12.776.049.407.249.500', 'D12.776.543.039.500'], ['D12.776.049.407.249', 'D12.776.543.039', 'D12.776.645.468.500', 'D12.776.811.050'], ['B01.050'], ['A08.186.211'], ['A11.251'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['C22... | ['Diseases [C]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Has the prevalence of invalidating musculoskeletal pain changed over the last 15 years (1993-2006)? A Spanish population-based survey. | UNLABELLED: The aim of the current study was to estimate the prevalence and time trend of invalidating musculoskeletal pain in the Spanish population and its association with socio-demographic factors, lifestyle habits, self-reported health status, and comorbidity with other diseases analyzing data from 1993-2006 Spani... | ['Adolescent', 'Adult', 'Aged', 'Chronic Disease', 'Comorbidity', 'Cross-Sectional Studies', 'Female', 'Humans', 'Male', 'Middle Aged', 'Musculoskeletal Diseases', 'Pain', 'Prevalence', 'Socioeconomic Factors', 'Spain', 'Young Adult'] | 20,356,799 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['C23.550.291.500'], ['N05.715.350.225', 'N06.850.490.687'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C05'], ['C23.888.592.612', 'F02.830.816.444', 'G11.5... | ['Named Groups [M]', 'Diseases [C]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Using secondary outcome to sharpen bounds for treatment harm rate in characterizing heterogeneity. | In a clinical trial, statistical reports are typically concerned about the mean difference in two groups. Now there is increasing interest in the heterogeneity of the treatment effect, which has important implications in treatment evaluation and selection. The treatment harm rate (THR), which is defined by the proporti... | ['Biometry', 'Clinical Trials as Topic', 'Data Interpretation, Statistical', 'Humans', 'Models, Statistical', 'Programming, Linear', 'Treatment Outcome'] | 29,911,355 | [['E05.318.740.225', 'N06.850.505.200'], ['E05.318.372.250.250', 'N05.715.360.330.250.250', 'N06.850.520.450.250.250'], ['E05.245.380', 'E05.318.740.300', 'L01.313.500.750.190.380', 'N05.715.360.750.300', 'N06.850.520.830.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500', 'E05.599.835', 'N05.71... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Information Science [L]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Development of an intraoral device for social inclusion of a physically disabled patient. | The aim of this study is to describe the use of an intraoral assistive technology for a patient with idiopathic generalized muscular dystonia, presenting temporomandibular disorder and severe anterior tooth mobility and diastema. A multidisciplinary team developed an intraoral device to provide typing and painting func... | ['Adult', 'Dental Care for Disabled', 'Diastema', 'Dystonic Disorders', 'Female', 'Humans', 'Occlusal Splints', 'Temporomandibular Joint Disorders'] | 26,578,336 | [['M01.060.116'], ['E06.170.310', 'N02.421.240.190.230'], ['C07.650.800.320', 'C07.793.700.320', 'C16.131.850.800.320'], ['C10.228.662.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E07.858.442.743.829'], ['C05.500.607.221.897', 'C05.550.905', 'C05.651.243.897', 'C07.320.610.291.897', 'C07.678']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
When may the posterior capsule be preserved in pediatric intraocular lens surgery? | PURPOSE: To refine indications for primary posterior capsulotomy (PPC) in conjunction with posterior chamber intraocular lens (PCIOL) implantation for cataract in childhood.DESIGN: Noncomparative case series.PARTICIPANTS: Patients 1 to 13 years old who underwent cataract extraction with intent to preserve the posterior... | ['Adolescent', 'Age Factors', 'Cataract', 'Cataract Extraction', 'Child', 'Child, Preschool', 'Female', 'Follow-Up Studies', 'Humans', 'Infant', 'Laser Therapy', 'Lens Capsule, Crystalline', 'Lens Implantation, Intraocular', 'Male', 'Pseudophakia', 'Risk Factors', 'Safety', 'Time Factors', 'Visual Acuity', 'Vitrectomy'... | 11,825,817 | [['M01.060.057'], ['N05.715.350.075', 'N06.850.490.250'], ['C11.510.245'], ['E04.540.825.249'], ['M01.060.406'], ['M01.060.406.448'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['E02.594', 'E04.014.520'], [... | ['Named Groups [M]', 'Health Care [N]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
PGE2 involvement in experimental infection with Trypanosoma cruzi subpopulations. | PGE2 involvement in experimental Trypanosoma cruzi infection depends on the lethal capacity of the parasite subpopulation used. Mice acutely infected with non-lethal K98 displayed an enhancement in PGE2 serum levels during the acute period, while those infected with lethal T. cruzi subpopulations (RA or K98-2) showed l... | ['16,16-Dimethylprostaglandin E2', 'Animals', 'Aspirin', 'Cell Adhesion', 'Chagas Disease', 'Dinoprostone', 'Indomethacin', 'Leukocyte Count', 'Male', 'Mice', 'Mice, Inbred C3H', 'T-Lymphocytes', 'Trypanosoma cruzi'] | 7,652,183 | [['D10.251.355.255.550.775.450.300', 'D23.469.050.175.725.775.450.300', 'D23.469.700.660.200'], ['B01.050'], ['D02.455.426.559.389.657.410.595.176'], ['G04.022'], ['C01.610.752.300.900.200', 'C01.920.625'], ['D10.251.355.255.550.250.200', 'D23.469.050.175.725.250.200'], ['D03.633.100.473.420'], ['E01.370.225.500.195.10... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Age-dependent epileptic encephalopathy: a longitudinal study. | A longitudinal clinico-electroencephalographic study was conducted on 484 cases of age-dependent epileptic encephalopathy; early-infantile epileptic encephalopathy with suppression-burst (Ohtahara) (EIEE), the West and Lennox syndromes. 1) The three types had the same kind of etiologic heterogeneity. 2) An evolutional ... | ['Brain', 'Brain Diseases', 'Cerebral Palsy', 'Child', 'Child Development', 'Child, Preschool', 'Electroencephalography', 'Encephalitis', 'Epilepsy', 'Evoked Potentials', 'Female', 'Humans', 'Infant', 'Intellectual Disability', 'Longitudinal Studies', 'Male', 'Prognosis', 'Spasms, Infantile', 'Tuberous Sclerosis'] | 7,327,468 | [['A08.186.211'], ['C10.228.140'], ['C10.228.140.140.254'], ['M01.060.406'], ['F01.525.200', 'G07.345.374.750'], ['M01.060.406.448'], ['E01.370.376.300', 'E01.370.405.245'], ['C10.228.140.430'], ['C10.228.140.490'], ['G07.265.216.500', 'G11.561.200.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703']... | ['Anatomy [A]', 'Diseases [C]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Hydrogen ion modulation of Ca channel current in cardiac ventricular cells. Evidence for multiple mechanisms. | We have investigated the effects of H ions on (L-type) Ca channel current in isolated ventricular cells. We find that the current amplitude is enhanced in solutions that are alkaline relative to pH 7.4 and reduced in solutions acidic to this pH. We measured pH0-induced shifts in channel gating and analyzed our results ... | ['Animals', 'Calcium', 'Electric Conductivity', 'Female', 'Guinea Pigs', 'Hydrogen-Ion Concentration', 'Ion Channels', 'Male', 'Membrane Potentials', 'Myocardium', 'Protons', 'Rats', 'Rats, Inbred Strains'] | 2,458,428 | [['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['G01.358.500.249.277'], ['B01.050.150.900.649.313.992.550'], ['G02.300'], ['D12.776.157.530.400', 'D12.776.543.550.450', 'D12.776.543.585.400'], ['G01.154.535', 'G04.580', 'G07.265.675', 'G11.561.570'], ['A02.633.580', 'A07.541.704', 'A10.690.552.750... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
In vitro release studies of insulin from lipid implants in solution and in a hydrogel matrix mimicking the subcutis. | Widely accepted in vitro methodologies for sustained release parenteral drug formulations remain to be established. Hydrogels have been proposed as a release matrix more closely resembling the in vivo conditions for formulations intended for subcutaneous administration. The perspective of the current work was to invest... | ['Delayed-Action Preparations', 'Drug Implants', 'Drug Liberation', 'Hydrogels', 'Hydrogen-Ion Concentration', 'Insulin', 'Lipids', 'Models, Theoretical', 'Solutions', 'Subcutaneous Tissue'] | 26,478,185 | [['D26.255.210', 'E02.319.300.253'], ['D26.255.210.315'], ['G02.211', 'G03.787.321', 'G07.690.725.321'], ['D20.280.320.375', 'D26.255.165.320.375'], ['G02.300'], ['D06.472.699.587.200.500.625', 'D12.644.548.586.200.500.625'], ['D10'], ['E05.599'], ['D26.776'], ['A10.165.887']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bikunin, a serine protease inhibitor, is present on the cell boundary of epidermis. | Bikunin, which is an inhibitor of serine proteases, is widely distributed in human tissues, including liver, kidney, and mucous membranes of the stomach and colon. The aim of this study was to clarify whether bikunin is expressed in human epidermis and its appendages. Immunoblot analysis using a specific polyclonal ant... | ['Antibodies', 'Cell Line', 'Cross Reactions', 'Epidermal Cells', 'Epidermis', 'Glycoproteins', 'Hair Follicle', 'Humans', 'Immunoblotting', 'Keratinocytes', 'Membrane Glycoproteins', 'RNA, Messenger', 'Serine Proteinase Inhibitors', 'Sweat Glands', 'Trypsin Inhibitor, Kunitz Soybean'] | 10,469,301 | [['D12.776.124.486.485.114', 'D12.776.124.790.651.114', 'D12.776.377.715.548.114'], ['A11.251.210'], ['G12.122.281'], ['A11.409'], ['A10.272.497', 'A17.815.250'], ['D09.400.430', 'D12.776.395'], ['A10.272.497.500', 'A17.360.710', 'A17.815.250.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.478.566.320', '... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Unique V kappa group associated with two mouse L chain genetic markers. | The C.C58 and C.AKR congeneic strains of mice differ from BALB/c at loci on chromosome 6 which govern kappa light chain variable region (V kappa) polymorphisms and the Lyt-2 and Lyt-3 alloantigens. Amino acid sequence analysis of light chains of myelomas induced in these strains revealed one light chain, C.C58 M75, tha... | ['Amino Acid Sequence', 'Animals', 'Binding Sites, Antibody', 'Immunoglobulin Light Chains', 'Immunoglobulin Variable Region', 'Immunoglobulin kappa-Chains', 'Isoelectric Focusing', 'Mice', 'Mice, Inbred Strains', 'Myeloma Proteins', 'Polymorphism, Genetic'] | 6,787,595 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.060.425.079', 'G02.111.570.120.408', 'G12.122.232', 'G12.125'], ['D12.776.124.486.485.705.750', 'D12.776.124.790.651.705.750', 'D12.776.377.715.548.705.750'], ['D12.644.541.500.650.500', 'D12.776.124.486.485.680.650.500', 'D12.776.124.486.485.797',... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
The distribution of bovine pancreatic polypeptide/FMRFamide-like immunoreactivity in the ventral nervous system of the locust. | The distribution of bovine pancreatic polypeptide (BPP) FMRFamide-like immunoreactivity is described in the ganglia of the ventral nerve cord and in the peripheral median nervous system of the locust, Schistocerca gregaria. Immunoreactive cell bodies occur in three regions of the thoracic ganglia: 1) two pairs of cells... | ['Animals', 'Antigens', 'Epitopes', 'FMRFamide', 'Ganglia', 'Grasshoppers', 'Oligopeptides', 'Pancreatic Polypeptide', 'Species Specificity'] | 2,579,985 | [['B01.050'], ['D23.050'], ['D23.050.550'], ['D12.644.400.235', 'D12.776.631.650.235'], ['A08.340'], ['B01.050.500.131.617.678.369'], ['D12.644.456'], ['D06.472.699.587.700', 'D12.644.400.600', 'D12.644.548.586.700', 'D12.776.631.650.600'], ['G16.824']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Expert consensus v. evidence-based approaches in the revision of the DSM. | The development of DSM-III through DSM-5 has relied heavily on expert consensus. In this essay, we provide an historical and critical perspective on this process. Over the last 40 years, medicine has struggled to find appropriate methods for summarizing research results and making clinical recommendations. When such re... | ['Consensus', 'Consensus Development Conferences as Topic', 'Diagnostic and Statistical Manual of Mental Disorders', 'Evidence-Based Medicine', 'History, 20th Century', 'History, 21st Century', 'Humans'] | 27,071,528 | [['F01.829.316.068', 'F02.463.785.373.433'], ['L01.178.682.759.150', 'N03.540.199.205'], ['L01.453.245.945.200'], ['H02.249.750', 'H02.403.200.400'], ['K01.400.504.968'], ['K01.400.504.984'], ['B01.050.150.900.649.313.988.400.112.400.400']] | ['Psychiatry and Psychology [F]', 'Information Science [L]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Humanities [K]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Distribution of collagens type I, type III and type V in the pancreas of rat, dog, pig and man. | The presence of collagens type I, type III and type V was determined immunohistochemically in pancreatic tissue of rat, pig, dog and man. The reaction to anti-collagen type I is weak (pig, dog) or moderate (rat, man) in the peri-insular region and in the lobar, lobular and acinar septa, whereas the reaction to anti-col... | ['Adult', 'Aging', 'Animals', 'Collagen', 'Dogs', 'Female', 'Humans', 'Immunohistochemistry', 'Male', 'Pancreas', 'Rats', 'Rats, Wistar', 'Species Specificity', 'Swine'] | 8,055,531 | [['M01.060.116'], ['G07.345.124'], ['B01.050'], ['D05.750.078.280', 'D12.776.860.300.250'], ['B01.050.150.900.649.313.750.250.216.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.2... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Randomized controlled trial of the safety and efficacy of Daptomycin versus standard-of-care therapy for management of patients with osteomyelitis associated with prosthetic devices undergoing two-stage revision arthroplasty. | The prevalence of Staphylococcus aureus causing prosthetic joint infection (PJI) supports investigation of higher doses of daptomycin in the management of PJI. This was a prospective, randomized controlled trial studying safety and efficacy of daptomycin (6 and 8 mg/kg of body weight) compared with standard-of-care the... | ['Adult', 'Aged', 'Aged, 80 and over', 'Anti-Bacterial Agents', 'Arthroplasty, Replacement, Hip', 'Arthroplasty, Replacement, Knee', 'Biomarkers', 'Creatine Kinase', 'Daptomycin', 'Drug Administration Schedule', 'Female', 'Hip Prosthesis', 'Humans', 'Knee Prosthesis', 'Male', 'Middle Aged', 'Osteomyelitis', 'Penicillin... | 22,908,174 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.954.122.085'], ['E04.555.110.110.110', 'E04.650.110.110', 'E04.680.101.110.110'], ['E04.555.110.110.115', 'E04.650.110.115', 'E04.680.101.110.115'], ['D23.101'], ['D08.811.913.696.640.150'], ['D04.345.566.270', 'D10.477.500', 'D12.644.365.500', '... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Passive current redistribution in the heart. | INTRODUCTION: Electrical stimuli produce a spatial distribution of voltage across the heart. We hypothesized that the potential difference between tissue near a stimulating electrode and a remote site could cause sufficient current to flow through a highly conductive wire connecting the two sites to directly stimulate ... | ['Animals', 'Cardiac Pacing, Artificial', 'Electric Conductivity', 'Equipment Design', 'Heart', 'Models, Cardiovascular', 'Pacemaker, Artificial', 'Swine', 'Vena Cava, Superior', 'Ventricular Function, Left', 'Ventricular Function, Right'] | 11,291,810 | [['B01.050'], ['E02.331.200'], ['G01.358.500.249.277'], ['E05.320'], ['A07.541'], ['E05.599.395.161'], ['E07.305.250.750'], ['B01.050.150.900.649.313.500.880'], ['A07.015.908.949.815'], ['G09.330.955.800'], ['G09.330.955.900']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Spontaneous ruptures of allotransplants of human cadaveric kidneys]. | On the basis of morphological data it was established that spontaneous ruptures of allotransplanted kidneys of man were connected mainly with juxtamedullar shunting of their blood flow; Impairment of the blood flow was apparently caused both by immune and nonimmune endogenous humoral factors. The pathomorphological pic... | ['Adolescent', 'Adult', 'Humans', 'Kidney', 'Kidney Diseases', 'Kidney Transplantation', 'Postoperative Complications', 'Rupture, Spontaneous', 'Transplantation, Homologous'] | 773,349 | [['M01.060.057'], ['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A05.810.453'], ['C12.777.419', 'C13.351.968.419'], ['E02.870.500', 'E04.936.450.485', 'E04.950.774.400'], ['C23.550.767'], ['C23.300.909'], ['E04.936.864']] | ['Named Groups [M]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Does a dynamic chair increase office workers' movements? - Results from a combined laboratory and field study. | PURPOSE: Dynamic chairs have the potential to facilitate movements that could counteract health problems associated with sedentary office work. This study aimed to evaluate whether a dynamic chair can increase movements during desk-based office work.METHODS: Fifteen healthy subjects performed desk-based office work usi... | ['Accelerometry', 'Adult', 'Ergonomics', 'Female', 'Humans', 'Interior Design and Furnishings', 'Male', 'Middle Aged', 'Movement', 'Occupational Health', 'Posture', 'Random Allocation', 'Task Performance and Analysis', 'Torso', 'Upper Extremity', 'Workplace', 'Young Adult'] | 28,166,867 | [['E05.003'], ['M01.060.116'], ['F02.784.412', 'J01.293.556'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['J01.086.339.290'], ['M01.060.116.630'], ['G07.568', 'G11.427.410'], ['N01.400.525'], ['G11.427.695'], ['E05.318.370.700', 'E05.581.500.805', 'N05.715.360.325.675', 'N06.850.520.445.700'], ['F02.784.412.846'... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Parental intention to have daughters receive the human papillomavirus vaccine. | BACKGROUND: Concerns have been raised that parents may be reluctant to have their daughters receive the human papillomavirus (HPV) vaccine, because of a belief that doing so might be interpreted as condoning earlier and more frequent sexual activity. We determined intentions regarding vaccination among Canadian parents... | ['Adolescent', 'Adult', 'Age Distribution', 'Canada', 'Child', 'Female', 'Health Care Surveys', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Intention', 'Logistic Models', 'Male', 'Multivariate Analysis', 'Odds Ratio', 'Papillomavirus Infections', 'Papillomavirus Vaccines', 'Parents', 'Patient Compliance', 'Sex ... | 18,056,599 | [['M01.060.057'], ['M01.060.116'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['Z01.107.567.176'], ['M01.060.406'], ['E05.318.308.980.344', 'N03.349.380.210', 'N05.425.210', 'N05.715.360.300.800.344', 'N06.850.520.308.980.344'], ['F01.100.150.500', 'N05.300.150.410'], ['B01.050.150.900.649.313.988.400.112.4... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Osteolysis in third-generation alumina ceramic-on-ceramic hip bearings with severe impingement and titanium metallosis. | The most common cause of long-term failure of total hip arthroplasty is osteolysis and aseptic loosening secondary to wear debris. Combinations of hard materials such as ceramic-on-ceramic generate smaller volumes of particulate wear debris than traditional combinations such as metal-on-polyethylene. We describe 2 case... | ['Adult', 'Aluminum Oxide', 'Arthroplasty, Replacement, Hip', 'Ceramics', 'Female', 'Hip Joint', 'Hip Prosthesis', 'Humans', 'Male', 'Middle Aged', 'Osteolysis', 'Range of Motion, Articular', 'Titanium'] | 18,534,463 | [['M01.060.116'], ['D01.056.050', 'D01.650.550.050'], ['E04.555.110.110.110', 'E04.650.110.110', 'E04.680.101.110.110'], ['J01.637.153'], ['A02.835.583.411'], ['E07.695.400.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C05.116.264.579', 'G11.427.213.150.570'], ['E01.370.600.700', 'G11.4... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 |
Elevated pain thresholds correlate with dissociation and aversive arousal in patients with borderline personality disorder. | In addition to reduced pain perception, patients with borderline personality disorder (BPD) show higher pain thresholds under subjective stress conditions as compared with non-stress conditions. However, the correlation between symptoms of stress and pain thresholds has not been investigated so far. Using a new and con... | ['Adult', 'Arousal', 'Borderline Personality Disorder', 'Diagnostic and Statistical Manual of Mental Disorders', 'Dissociative Disorders', 'Escape Reaction', 'Female', 'Humans', 'Pain', 'Pain Measurement', 'Pain Threshold', 'Psychometrics', 'Self-Injurious Behavior', 'Severity of Illness Index', 'Stress, Psychological'... | 17,126,914 | [['M01.060.116'], ['F02.830.104', 'G11.561.035'], ['F03.675.100'], ['L01.453.245.945.200'], ['F03.300'], ['F01.145.113.780.688', 'F01.145.367', 'F01.145.875.439.500.688', 'G07.568.500.590.688', 'G11.427.410.568.850.688'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.888.592.612', 'F02.830.816.444', 'G11.561.7... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Diabetes mellitus and expression of the enterocyte renin-angiotensin system: implications for control of glucose transport across the brush border membrane. | Streptozotocin-induced (Type 1) diabetes mellitus (T1DM) in rats promotes jejunal glucose transport, but the trigger for this response remains unclear. Our recent work using euglycemic rats has implicated the enterocyte renin-angiotensin system (RAS) in control of sodium-dependent glucose transporter (SGLT1)-mediated g... | ['Animals', 'Biological Transport, Active', 'Blood Glucose', 'Diabetes Mellitus, Experimental', 'Enterocytes', 'Gene Expression Regulation', 'Glucose', 'Glucose Transporter Type 2', 'Jejunum', 'Male', 'Microvilli', 'RNA, Messenger', 'Rats', 'Rats, Wistar', 'Renin-Angiotensin System', 'Sodium-Glucose Transporter 1'] | 19,535,516 | [['B01.050'], ['G03.143.310'], ['D09.947.875.359.448.500'], ['C18.452.394.750.074', 'C19.246.240', 'E05.598.500.374'], ['A03.556.124.369.290', 'A10.615.550.444.290', 'A11.436.290'], ['G05.308'], ['D09.947.875.359.448'], ['D12.776.157.530.500.500.750', 'D12.776.157.530.937.563.750', 'D12.776.543.585.500.500.750', 'D12.7... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Ineffectiveness of cough for enhancing mucus clearance in asymptomatic smokers. | Using monodisperse aerosols radiolabeled with 99mTc, we studied the effectiveness of cough and rapid inhalations for clearing mucus in ten asymptomatic smokers. On three separate study days, each subject breathed 5 microns (MMAD) 99mTc-iron oxide particles under controlled breathing conditions. While seated in front of... | ['Aerosols', 'Cough', 'Female', 'Ferric Compounds', 'Gamma Cameras', 'Humans', 'Male', 'Mucociliary Clearance', 'Radionuclide Imaging', 'Respiratory Mechanics', 'Smoking', 'Technetium', 'Time Factors', 'Xenon Radioisotopes'] | 1,643,924 | [['D20.280.055', 'D26.255.165.055'], ['C08.618.248', 'C23.888.852.293'], ['D01.490.100'], ['E07.420'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.386.520', 'G09.772.555'], ['E01.370.350.710', 'E01.370.384.730'], ['G09.772.705.700'], ['F01.145.805'], ['D01.268.271.870', 'D01.268.556.843', 'D01.268.956.87... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Human parechovirus-3 infection: emerging pathogen in neonatal sepsis. | Human parechovirus-3 (HPeV-3) is an emerging pathogen that has been described as a cause of neonatal sepsis. Human parechoviruses are a family of viruses closely related to enteroviruses; however, enteroviral PCR will not detect HPeVs. We present clinical details of neonatal meningoencephalitis and hepatitis-coagulopat... | ['Acyclovir', 'Antiviral Agents', 'Cerebrospinal Fluid', 'Humans', 'Infant, Newborn', 'Male', 'Meningoencephalitis', 'Parechovirus', 'Picornaviridae Infections', 'Polymerase Chain Reaction', 'Sepsis'] | 19,483,524 | [['D03.633.100.759.758.399.454.250'], ['D27.505.954.122.388'], ['A12.207.270.210'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['C01.207.245.550', 'C01.207.570', 'C10.228.140.430.550', 'C10.228.228.245.550', 'C10.228.228.570', 'C10.228.614.500'], ['B04.820.578.750.700'], ['C01.925.782.687'], ... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Women's experiences of an altered appearance during chemotherapy: an indication of cancer status. | This study explores breast cancer patients' experiences of chemotherapy treatment, with a focus on the impact of an altered appearance during this time. We present two key themes from the thematic analysis of interviews with 19 women: anxiety that chemotherapy will render them identifiable as a ;person-with-cancer'; an... | ['Adult', 'Drug Therapy', 'Female', 'Humans', 'Neoplasm Staging', 'Neoplasms', 'Self Concept', 'Social Desirability'] | 18,519,434 | [['M01.060.116'], ['E02.319'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.789.625'], ['C04'], ['F01.752.747.792'], ['F01.145.813.628']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A new species of Discocyrtoides from southern Brazilian pine forest (Opiliones, Gonyleptidae, Mitobatinae). | Discocyrtoidespinorum sp. nov. is described from the conifers forest in Paran? State, Southern Brazil. This is the second species of Discocyrtoides Mello-Leit?o, 1923, the other being known from S?o Paulo State. It is remarkable for having greenish/yellowish spots in the dorsal scutum highly contrasting with the brown ... | ['Animals', 'Arachnida', 'Brazil', 'Forests', 'Microscopy, Electron', 'Pinus', 'Terminology as Topic', 'Tracheophyta'] | 31,176,589 | [['B01.050'], ['B01.050.500.131.166'], ['Z01.107.757.176'], ['G16.500.275.157.437', 'N06.230.124.343'], ['E01.370.350.515.402', 'E05.595.402'], ['B01.650.940.800.575.912.625.875.777'], ['L01.559.598.400'], ['B01.650.940.800.575.912']] | ['Organisms [B]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 |
RS1 satellite phage promotes diversity of toxigenic Vibrio cholerae by driving CTX prophage loss and elimination of lysogenic immunity. | In El Tor biotype strains of toxigenic Vibrio cholerae, the CTX? prophage often resides adjacent to a chromosomally integrated satellite phage genome, RS1, which produces RS1? particles by using CTX prophage-encoded morphogenesis proteins. RS1 encodes RstC, an antirepressor against the CTX? repressor RstR, which cooper... | ['Animals', 'Bacterial Proteins', 'Bacteriophages', 'Cholera', 'Cholera Toxin', 'Genes, Bacterial', 'Intestines', 'Lysogeny', 'Prophages', 'Rabbits', 'Serine Endopeptidases', 'Vibrio cholerae'] | 24,935,981 | [['B01.050'], ['D12.776.097'], ['B04.123'], ['C01.150.252.400.959.347'], ['D08.811.913.400.725.115.180', 'D23.946.123.194', 'D23.946.330.150'], ['G05.360.340.024.340.364.249', 'G05.360.340.358.024.249', 'G05.360.340.358.207.249'], ['A03.556.124'], ['G05.935.500', 'G06.920.877.500'], ['B04.123.655'], ['B01.050.150.900.6... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Effects of La3+ on calcium binding to erythrocyte cytoskeleton]. | When the whole erythrocytes were exposed to LaCl3, A--23187, ionomycin, orthovanadate and saponin, there was Ca2+ binding only following La3+ treatment of the cells. The binding was evident at a wide range (0.1 microM--1.OmM) of La3+ concentrations. Iodoacetamide-induced (incubation for 3 hours, 37 degrees C) decrease ... | ['Adenosine Triphosphate', 'Animals', 'Calcium', 'Calcium-Transporting ATPases', 'Cytoskeleton', 'Erythrocytes', 'Female', 'Humans', 'Lanthanum', 'Pregnancy', 'Rats'] | 1,535,234 | [['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D08.811.277.040.025.314.250', 'D12.776.157.530.450.250.500', 'D12.776.157.530.813.250', 'D12.776.543.585.450.250.500', 'D12.776.543.585.813.250'], ['A11.284.430.214.190.7... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A new species of Chrysozephyrus associated with Lithocarpus corneus (Lepidoptera: Lycaenidae: Theclini). | Chrysozephyrus laoshanensis, sp. nov., is described and illustrated from Cenwanglaoshan in the western part of Guangxi Province, China and Ha Giang Province of Vietnam. The new species is associated with Lithocarpus corneus, which has not previously been recognized as a hostplant for Theclini or any lepidopterous speci... | ['Animals', 'Butterflies', 'China', 'Lepidoptera', 'Vietnam'] | 29,690,061 | [['B01.050'], ['B01.050.500.131.617.720.500.500.937.200'], ['Z01.252.474.164'], ['B01.050.500.131.617.720.500.500.937'], ['Z01.252.145.945']] | ['Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Treatment outcome for earlier-phase alcoholics. | Employed alcoholics treated in a traditional inpatient alcoholism treatment program were classified by their alcoholism counselors as being in either the chronic phase or in earlier phases of alcoholism. Three-month follow-up data indicated that a significantly smaller proportion (41%) of the earlier-phase alcoholics t... | ['Adult', 'Age Factors', 'Alcohol Drinking', 'Alcoholism', 'Follow-Up Studies', 'Humans', 'Male', 'Marriage', 'Socioeconomic Factors', 'Time Factors'] | 1,072,388 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['F01.145.317.269'], ['C25.775.100.250', 'F03.900.100.350'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.263.315.500.500', 'I01.240.361.500.500', 'I01.880.8... | ['Named Groups [M]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Fluorometric liquid-chromatographic determination of serum cortisol. | We describe a sensitive and specific liquid-chromatographic assay for serum cortisol, exploiting acid-induced fluorescence. Each analysis requires only 50 microL of serum, and chromatography is complete in 7 min. Analytical recovery of cortisol added to serum ranged from 90 to 105% and between-run precision (CV) from 6... | ['Chromatography, Liquid', 'Humans', 'Hydrocortisone', 'Spectrometry, Fluorescence'] | 7,471,396 | [['E05.196.181.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D04.210.500.745.745.654.600', 'D06.472.040.585.353.476', 'D06.472.040.585.478.392'], ['E05.196.712.516.600.676', 'E05.196.867.726']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Covering their butts: responses to the cigarette litter problem. | BACKGROUND: Cigarette butt litter is a potential target of tobacco control. In addition to its toxicity and non-biodegradability, it can justify environmental regulation and policies that raise the price of tobacco and further denormalise its use. This paper examines how the tobacco industry has managed the cigarette b... | ['Air Pollution', 'Conservation of Natural Resources', 'Environmental Pollution', 'Humans', 'Mass Media', 'Public Opinion', 'Refuse Disposal', 'Smoking', 'Tobacco Industry', 'United States'] | 20,966,130 | [['N06.850.460.100'], ['J01.256', 'N06.230.080'], ['N06.850.460'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.178.590'], ['I01.880.630.548'], ['N06.850.780.200.800.800.700', 'N06.850.860.510.900.600'], ['F01.145.805'], ['J01.576.655.968'], ['Z01.107.567.875']] | ['Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Information Science [L]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 1 |
DNA repair synthesis facilitates RAD52-mediated second-end capture during DSB repair. | Homologous recombination (HR) is essential for the repair of DNA double-strand breaks (DSBs) in mitotic and meiotic cells. HR occurs through a series of steps involving DSB resection, invasion of single-stranded DNA into homologous duplex DNA to form a D loop, repair synthesis, and second-end capture. We show that DNA ... | ['Animals', 'DNA Breaks, Double-Stranded', 'DNA Repair', 'DNA, Single-Stranded', 'DNA-Directed DNA Polymerase', 'Humans', 'Isoenzymes', 'Nucleic Acid Conformation', 'Rad51 Recombinase', 'Rad52 DNA Repair and Recombination Protein', 'Recombination, Genetic', 'Replication Protein A'] | 18,313,388 | [['B01.050'], ['G05.200.210.220'], ['G02.111.222', 'G05.219'], ['D13.444.308.497', 'G02.111.570.820.486.437', 'G05.360.580.437'], ['D08.811.913.696.445.308.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.348', 'D12.776.800.300'], ['G02.111.570.820.486', 'G05.360.580'], ['D08.811.739.650.500', 'D12.776... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Diabetes produced in mice by smoked/cured mutton. | There is circumstantial evidence of a causal connection between type 1 diabetes in young Icelandic males and consumption of smoked cured mutton, containing N-nitroso compounds, by their parents at about the time of conception. This hypothesis has been examined in CD1 mice, and such processed mutton, consumed by the par... | ['Animals', 'Animals, Newborn', 'Blood Glucose', 'Diabetes Mellitus, Experimental', 'Female', 'Food Additives', 'Food Preservation', 'Iceland', 'Islets of Langerhans', 'Male', 'Maternal-Fetal Exchange', 'Meat', 'Mice', 'Nitroso Compounds', 'Pregnancy', 'Sex Factors', 'Sheep'] | 6,127,504 | [['B01.050'], ['B01.050.050.282'], ['D09.947.875.359.448.500'], ['C18.452.394.750.074', 'C19.246.240', 'E05.598.500.374'], ['D27.720.372.300', 'G07.203.300.514.500', 'J02.500.514.500'], ['J01.576.423.850.700'], ['Z01.542.816.249', 'Z01.639.490'], ['A03.734.414', 'A06.300.414'], ['G08.686.784.769.455'], ['G07.203.300.60... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Geographicals [Z]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
Self-assembled core-shell nanoparticles for combined chemotherapy and photodynamic therapy of resistant head and neck cancers. | Combination therapy enhances anticancer efficacy of both drugs via synergistic effects. We report here nanoscale coordination polymer (NCP)-based core-shell nanoparticles carrying high payloads of cisplatin and the photosensitizer pyrolipid, NCP@pyrolipid, for combined chemotherapy and photodynamic therapy (PDT). NCP@p... | ['Animals', 'Cell Line, Tumor', 'Cisplatin', 'Combined Modality Therapy', 'Drug Carriers', 'Drug Resistance, Neoplasm', 'Female', 'Head and Neck Neoplasms', 'Humans', 'Mice', 'Nanomedicine', 'Nanoparticles', 'Photochemotherapy', 'Photosensitizing Agents', 'Polymers'] | 25,559,017 | [['B01.050'], ['A11.251.210.190', 'A11.251.860.180'], ['D01.210.375', 'D01.625.125', 'D01.710.100'], ['E02.186'], ['D26.255.260', 'E02.319.300.380'], ['G07.690.773.984.395'], ['C04.588.443'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649.313.992.635.505.500'], ['H01.603.600', 'J01.897.120.050.6... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Disruption of oligomerization and dehydroalanine formation as mechanisms for ClpP protease inhibition. | Over 100 protease inhibitors are currently used in the clinics, and most of them use blockage of the active site for their mode of inhibition. Among the protease drug targets are several enzymes for which the correct multimeric assembly is crucial to their activity, such as the proteasome and the HIV protease. Here, we... | ['Alanine', 'Endopeptidase Clp', 'Models, Molecular', 'Molecular Structure', 'Protease Inhibitors', 'Structure-Activity Relationship'] | 24,106,749 | [['D12.125.042'], ['D08.811.277.040.013.500.032.099.500', 'D08.811.277.040.025.024.032.099.500', 'D08.811.277.656.149.099.500', 'D08.811.277.656.300.065.500', 'D12.776.157.025.750.032.099.500', 'D12.776.575.374', 'D12.776.765.199.249'], ['E05.599.595'], ['G02.111.570', 'G02.466'], ['D27.505.519.389.745'], ['G02.111.830... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
An integrated approach to mapping the proteome of the human bone marrow stromal cell. | Bone marrow stromal cells, also known as mesenchymal stem or progenitor cells, are thought to play a critical role in hematopoiesis. Because hematopoiesis is dysregulated in leukemic individuals, expression profiling in leukemic stromal cells might yield valuable insights into mechanisms of normal and dysregulated hema... | ['Adult', 'Bone Marrow Cells', 'Cell Separation', 'Cells, Cultured', 'Chromatography, Liquid', 'Female', 'Humans', 'Male', 'Mass Spectrometry', 'Middle Aged', 'Proteins', 'Proteome', 'Proteomics', 'Stromal Cells', 'Tumor Cells, Cultured'] | 16,947,122 | [['M01.060.116'], ['A11.148', 'A15.378.316'], ['E01.370.225.500.363', 'E05.200.500.363', 'E05.242.363'], ['A11.251'], ['E05.196.181.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.196.566'], ['M01.060.116.630'], ['D12.776'], ['D12.776.817'], ['H01.158.201.843', 'H01.158.273.180.350.700', 'H01.158.273.343.... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Evaluation of latent tuberculosis infection in patients with inflammatory arthropathies before treatment with TNF-alpha blocking drugs using a novel flow-cytometric interferon-gamma release assay. | OBJECTIVE: To compare the efficacy of the conventional skin test and a novel flow cytometric whole blood assay in the diagnosis of latent tuberculosis infection (LTBI) in patients with rheumatological diseases evaluated for treatment with TNF-alpha-blocking agents.METHODS: Prospective study of 97 consecutively enrolled... | ['Aged', 'Anti-Inflammatory Agents', 'Arthritis, Psoriatic', 'Arthritis, Rheumatoid', 'CD4-Positive T-Lymphocytes', 'Female', 'Flow Cytometry', 'Humans', 'Interferon-gamma', 'Male', 'Middle Aged', 'Mycobacterium tuberculosis', 'Prednisolone', 'Reproducibility of Results', 'Rheumatic Diseases', 'Sensitivity and Specific... | 18,208,824 | [['M01.060.116.100'], ['D27.505.954.158'], ['C05.116.900.853.625.800.424', 'C05.550.114.145', 'C05.550.114.865.800.424', 'C17.800.859.675.175'], ['C05.550.114.154', 'C05.799.114', 'C17.300.775.099', 'C20.111.199'], ['A11.118.637.555.567.569.200', 'A15.145.229.637.555.567.569.200', 'A15.382.490.555.567.569.200'], ['E01.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Activation of peritoneal macrophages in rats with caerulein-induced pancreatitis]. | We examined the stimulatory state of peritoneal macrophages (M phi) in caerulein-induced pancreatitis. Edematous pancreatitis was developed by the intravenous continuous injection of caerulein (5 micrograms/kg/hr) for 4 hr. Thereafter peritoneal M phi were collected and the activity for free radical production was meas... | ['Acute Disease', 'Animals', 'Ceruletide', 'Macrophage Activation', 'Macrophages, Peritoneal', 'Male', 'Pancreatitis', 'Rats', 'Rats, Inbred F344'] | 8,271,462 | [['C23.550.291.125'], ['B01.050'], ['D12.644.456.241'], ['G12.287.500'], ['A11.329.372.630', 'A11.627.482.630', 'A11.733.397.630', 'A15.382.670.522.630', 'A15.382.680.397.630'], ['C06.689.750'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760.200', 'B01.050.150.900.649.313.992.635.505.700.400.200... | ['Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Low cytomegalovirus-specific T-cell counts at reactivation are associated with progression to high-level viremia or disease in seropositive recipients of hematopoietic cell grafts from seropositive but not seronegative donors. | BACKGROUND AIMS: Identifying patients who spontaneously resolve cytomegalovirus (CMV) reactivation could spare these patients from the toxicity of antiviral drugs such as ganciclovir. The role of CMV-specific T cells in clearing CMV viremia in patients who do not receive ganciclovir has not been evaluated. We assessed ... | ['Adult', 'CD4-Positive T-Lymphocytes', 'Cytomegalovirus', 'Cytomegalovirus Infections', 'Disease Progression', 'Ganciclovir', 'Hematopoietic Stem Cell Transplantation', 'Humans', 'Interferon-gamma', 'Lymphocyte Count', 'Middle Aged', 'Tissue Donors', 'Viremia', 'Virus Activation', 'Virus Latency'] | 22,149,135 | [['M01.060.116'], ['A11.118.637.555.567.569.200', 'A15.145.229.637.555.567.569.200', 'A15.382.490.555.567.569.200'], ['B04.280.382.150.150'], ['C01.925.256.466.245'], ['C23.550.291.656'], ['D03.633.100.759.758.399.454.250.300'], ['E02.095.147.500.500.500', 'E04.936.225.687.500'], ['B01.050.150.900.649.313.988.400.112.4... | ['Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Expression of beta-amyloid precursor protein mRNAs following transient focal ischaemia. | beta-Amyloid precursor protein (beta APP) can be alternatively processed to result in release of either neurotoxic amyloid beta-peptide, or secreted forms of beta APP, which might have a role in neuronal plasticity and survival. Four different forms of beta APP mRNAs have been described in rodents: APP695, APP714, APP7... | ['Amyloid beta-Protein Precursor', 'Animals', 'Brain Ischemia', 'In Situ Hybridization', 'Male', 'Rats', 'Rats, Wistar'] | 8,981,456 | [['D12.776.049.407.249', 'D12.776.543.039', 'D12.776.645.468.500', 'D12.776.811.050'], ['B01.050'], ['C10.228.140.300.150', 'C14.907.253.092'], ['E01.370.225.500.620.670.325', 'E01.370.225.750.600.670.325', 'E05.200.500.620.670.325', 'E05.200.750.600.670.325', 'E05.393.661.475'], ['B01.050.150.900.649.313.992.635.505.7... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Male gender influences response to an educational package for delirium prevention among older people: a stratified analysis. | BACKGROUND: Increasing evidence is pointing towards the efficacy of intervention programmes in decreasing the incidence of delirium among older people admitted to hospital. We have previously shown that an educational package directed at doctors and nurses significantly decreased the point prevalence of delirium among ... | ['Age Factors', 'Aged', 'Aged, 80 and over', 'Delirium', 'Dementia', 'Female', 'Hospitalization', 'Humans', 'Inservice Training', 'London', 'Male', 'Medical Staff, Hospital', 'Nursing Staff, Hospital', 'Outcome Assessment, Health Care', 'Pilot Projects', 'Sex Factors'] | 16,676,296 | [['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C10.597.606.337.500', 'C23.888.592.604.339.500', 'F01.700.250.500', 'F03.615.350'], ['C10.228.140.380', 'F03.615.400'], ['E02.760.400', 'N02.421.585.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I02.574'], ['Z01.433.553... | ['Health Care [N]', 'Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
The AMPK â2 subunit is required for energy homeostasis during metabolic stress. | AMP activated protein kinase (AMPK) plays a key role in the regulatory network responsible for maintaining systemic energy homeostasis during exercise or nutrient deprivation. To understand the function of the regulatory â2 subunit of AMPK in systemic energy metabolism, we characterized â2 subunit-deficient mice. Using... | ['AMP-Activated Protein Kinases', 'Aminoimidazole Carboxamide', 'Animals', 'Diet, High-Fat', 'Energy Metabolism', 'Fasting', 'Glucose', 'Homeostasis', 'Metabolic Networks and Pathways', 'Metabolic Syndrome', 'Mice', 'Mice, 129 Strain', 'Mice, Inbred C57BL', 'Mice, Knockout', 'Muscle, Skeletal', 'Physical Exertion', 'Pr... | 22,586,267 | [['D08.811.913.696.620.682.700.085', 'D12.644.360.062', 'D12.776.476.062'], ['D03.383.129.308.030'], ['B01.050'], ['G07.203.650.240.267'], ['G03.295'], ['F01.145.407.400', 'G07.203.650.240.587', 'G07.203.650.353.400'], ['D09.947.875.359.448'], ['G07.410'], ['G03.493'], ['C18.452.394.968.500.570', 'C18.452.625'], ['B01.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Delay discrimination and reversal eyeblink classical conditioning in abstinent chronic alcoholics. | Evidence has shown that alcoholism leads to volume reductions in brain regions critical for associative learning using the eyeblink classical conditioning paradigm (EBCC). Evidence indicates that cerebellar shrinkage causes impairment in simple forms of EBCC, whereas changes in forebrain structures result in impairment... | ['Alcohol Drinking', 'Alcoholism', 'Cerebellum', 'Conditioning, Eyelid', 'Discrimination Learning', 'Discrimination, Psychological', 'Female', 'Humans', 'Male', 'Middle Aged', 'Neuropsychological Tests', 'Psychiatric Status Rating Scales', 'Psychomotor Performance', 'Reversal Learning', 'Temperance', 'Wechsler Scales'] | 18,331,162 | [['F01.145.317.269'], ['C25.775.100.250', 'F03.900.100.350'], ['A08.186.211.132.810.428.200'], ['F02.463.425.179.408'], ['F02.463.425.280'], ['F02.463.593.257'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['F04.711.513'], ['F04.711.513.653'], ['F02.808', 'G11.427.700', 'G11.561.660'], ['F02.4... | ['Psychiatry and Psychology [F]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Named Groups [M]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Mission and tasks of the Coordination Centres for Clinical Trials]. | Coordination Centres for Clinical Trials (Koordinierungszentren f?r Klinische Studien, KKS) were set up to increase the quality and number of clinical trials in Germany as well as to establish clinical trial training programs in order to improve international recognition of German clinical research. Over the past 6 yea... | ['Academic Medical Centers', 'Clinical Trials Data Monitoring Committees', 'Drug Industry', 'Germany', 'Humans', 'Interdisciplinary Communication', 'Multicenter Studies as Topic', 'Randomized Controlled Trials as Topic', 'Research Support as Topic'] | 19,263,026 | [['N02.278.020'], ['N05.700.685.149'], ['J01.576.655.750'], ['Z01.542.315'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.401.205.249', 'L01.143.865.500'], ['E05.318.372.658', 'N05.715.360.330.643', 'N06.850.520.450.643'], ['E05.318.372.250.250.365.500', 'N05.715.360.330.250.250.365.500', 'N06.850.520.450... | ['Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Geographicals [Z]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 |
Prevalence and determinant factors of malocclusion in population with special needs in South India. | OBJECTIVES: Malocclusion plays an important role in the overall oral health of an individual because it is associated with periodontal disease, temporomandibular disorders and may be complicated by an individual's disparity. Careful attention to malocclusion in children with special needs leads to a considerable improv... | ['Adolescent', 'Adult', 'Child', 'Cross-Sectional Studies', 'Diastema', 'Disabled Persons', 'Female', 'Habits', 'Hearing Disorders', 'Humans', 'Incidence', 'India', 'Intellectual Disability', 'Male', 'Malocclusion', 'Malocclusion, Angle Class I', 'Malocclusion, Angle Class II', 'Malocclusion, Angle Class III', 'Open Bi... | 23,886,718 | [['M01.060.057'], ['M01.060.116'], ['M01.060.406'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['C07.650.800.320', 'C07.793.700.320', 'C16.131.850.800.320'], ['M01.150'], ['F01.145.466'], ['C09.218.458', 'C10.597.751.418', 'C23.888.592.763.393'], ['B01.050.150.900.649.313.988.400.112... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Synthesis and biological evaluation of A-ring biaryl-carbamate analogues of rhazinilam. | An improvement of the synthesis of biphenyl-carbamate 2a, the most active analogue of rhazinilam 1 so far, was performed using the Pd-catalyzed borylation/Suzuki coupling (BSC) method developed in our laboratories. The preparation of A-ring analogues of 2a bearing electron-withdrawing or donating groups is reported acc... | ['Alkaloids', 'Antineoplastic Agents', 'Catalysis', 'Drug Screening Assays, Antitumor', 'Humans', 'Indicators and Reagents', 'Indolizines', 'Lactams', 'Microtubules', 'Palladium', 'Tumor Cells, Cultured'] | 12,213,452 | [['D03.132'], ['D27.505.954.248'], ['G02.130'], ['E01.370.225.500.388', 'E05.200.500.388', 'E05.242.417', 'E05.337.550.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.720.470.410'], ['D03.633.100.496'], ['D02.065.589', 'D03.383.411'], ['A11.284.430.214.190.750.602'], ['D01.268.556.680', 'D01.268.956.718',... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Direction-selective motion blindness after unilateral posterior brain damage. | Motion blindness (MB) is defined as the selective disturbance of visual motion perception despite intact perception of other features of the visual scene. MB is characterized by a pandirectional deficit of motion direction discrimination and is assumed to result from damage to the visual motion pathway, especially area... | ['Adult', 'Aged', 'Aged, 80 and over', 'Blindness', 'Brain Damage, Chronic', 'Discrimination, Psychological', 'Female', 'Humans', 'Image Processing, Computer-Assisted', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Motion Perception', 'Psychophysics', 'Sensory Thresholds'] | 12,911,768 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C10.597.751.941.162', 'C11.966.075', 'C23.888.592.763.941.162'], ['C10.228.140.140'], ['F02.463.593.257'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['E01.370.350.825.500'], ['M01.060.116.630'], ['F02.463.593.932.567'], ['E01.370.... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
The ultrastructure and development of the colonial sheath of Microcystis marginata. | The colonial sheath of Microcystis marginata has a definite structure as seen by light and electron microscopy, consisting of a relatively smooth inner surface and densely packed, long fibrils on the outer surface. The sheath initially forms around the single cell and expands by continual deposition of sheath material ... | ['Microcystis'] | 814,872 | [['B03.280.500', 'B03.440.475.100.500']] | ['Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Inhibition by anaesthetics of 14C-guanidinium flux through the voltage-gated sodium channel and the cation channel of the 5-HT3 receptor of N1E-115 neuroblastoma cells. | The influence of local and general anaesthetics on cation influx through the fast, voltage-dependent sodium channel and the 5-HT3 receptor cation channel was studied in N1E-115 mouse neuroblastoma cells by measuring 2-min influx of the organic cation 14C-guanidinium induced by either veratridine (1 mmol/l) or 5-HT (100... | ['Anesthesia, General', 'Anesthetics', 'Anesthetics, Local', 'Animals', 'Carbon Radioisotopes', 'Guanidine', 'Guanidines', 'Injections, Intravenous', 'Ion Channel Gating', 'Ion Channels', 'Mice', 'Neuroblastoma', 'Receptors, Serotonin', 'Serotonin', 'Serotonin Antagonists', 'Sodium Channels', 'Tumor Cells, Cultured', '... | 7,682,657 | [['E03.155.197'], ['D27.505.696.277.100', 'D27.505.954.427.210.100'], ['D27.505.696.277.100.200', 'D27.505.696.663.850.025', 'D27.505.954.427.210.100.200'], ['B01.050'], ['D01.268.150.075.328', 'D01.496.123.328', 'D01.496.749.154'], ['D02.078.370.472'], ['D02.078.370'], ['E02.319.267.082.750', 'E02.319.267.530.540'], [... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Pilot-scale bubble column photobioreactor culture of a marine dinoflagellate microalga illuminated with light emission diodes. | Production of biomass of the shear-sensitive marine algal dinoflagellate Karlodinium veneficum was successfully scaled-up to 80L using a bubble column photobioreactor. The scale factor exceeded 28,500. Light-emission diodes were used as the light source. The diel irradiance profile mimicked the outdoor profile of natur... | ['Biomass', 'Dinoflagellida', 'Light', 'Photobioreactors'] | 27,318,163 | [['G16.500.275.157.100', 'N06.230.124.100'], ['B01.043.214'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['E07.115.600', 'J01.897.120.115.600']] | ['Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Rapid Bioorthogonal Chemistry Enables in Situ Modulation of the Stem Cell Behavior in 3D without External Triggers. | Chemical modification of engineered microenvironments surrounding living cells represents a means for directing cellular behaviors through cell-matrix interactions. Presented here is a temporally controlled method for modulating the properties of biomimetic, synthetic extracellular matrices (ECM) during live cell cultu... | ['Cell Culture Techniques', 'Cell Differentiation', 'Chondrogenesis', 'Extracellular Matrix', 'Humans', 'Hydrogels', 'Mesenchymal Stem Cells', 'Stem Cells'] | 30,015,482 | [['E01.370.225.500.223', 'E05.200.500.265', 'E05.242.223', 'E05.481.500.249'], ['G04.152'], ['G07.345.500.325.377.625.180', 'G11.427.578.180'], ['A11.284.295.310'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D20.280.320.375', 'D26.255.165.320.375'], ['A11.329.830.500', 'A11.872.590.500'], ['A11.872']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cretaceous diversity and disparity in a lacewing lineage of predators (Neuroptera: Mantispidae). | Mantidflies (Mantispidae) are an unusual and charismatic group of predatory lacewings (Neuroptera), whereby the adults represent a remarkable case of morphological and functional convergence with praying mantises (Mantodea). The evolutionary history of mantidflies remains largely unknown due to a scarcity of fossils. H... | ['Amber', 'Animals', 'Biodiversity', 'Biological Evolution', 'Holometabola', 'Mantodea', 'Phylogeny'] | 32,486,975 | [['D05.750.078.840.109', 'D20.215.721.500.109'], ['B01.050'], ['G16.500.275.157.049', 'N06.230.124.049'], ['G05.045', 'G16.075'], ['B01.050.500.131.617.720.500.500'], ['B01.050.500.131.617.720.500.750'], ['G05.697', 'G16.075.605', 'L01.100.697']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Information Science [L]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Storage stability of microencapsulated cloudberry ( Rubus chamaemorus ) phenolics. | Cloudberries ( Rubus chamaemorus ) contain phenolics (mainly ellagitannins), which have recently been related to many valuable bioactivity properties. In general, phenolics are known to react readily with various components, which may create an obstacle in producing stable functional components for food and pharmaceuti... | ['Capsules', 'Drug Compounding', 'Drug Stability', 'Drug Storage', 'Phenols', 'Polysaccharides', 'Rosaceae'] | 18,989,975 | [['D26.255.150'], ['E05.916.270'], ['E05.916.330'], ['E05.916.350'], ['D02.455.426.559.389.657'], ['D09.698'], ['B01.650.940.800.575.912.250.859.937.500']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of suture tension and surgical approach during unilateral arytenoid lateralization on the rima glottidis in the canine larynx. | OBJECTIVES: To evaluate the effect of abduction suture tension and cricothyroid (CT) joint disarticulation on the area, height, and width of the rima glottidis (RG) during unilateral arytenoid lateralization.STUDY DESIGN: Experimental study.ANIMALS: Nine canine cadaver larynges.METHODS: Left arytenoid lateralization wa... | ['Animals', 'Arytenoid Cartilage', 'Biomechanical Phenomena', 'Cadaver', 'Dog Diseases', 'Dogs', 'Glottis', 'Suture Techniques', 'Vocal Cord Paralysis'] | 12,415,529 | [['B01.050'], ['A02.165.257.625.083', 'A02.165.407.500.083', 'A04.329.591.085'], ['G01.154.090', 'G01.374.089'], ['C23.550.260.224'], ['C22.268'], ['B01.050.150.900.649.313.750.250.216.200'], ['A04.329.364'], ['E04.987.775'], ['C08.360.931', 'C09.400.931', 'C10.292.887.800', 'C10.597.622.943', 'C23.888.592.636.943']] | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Developing a general ward nursing dashboard. | The seventh and final article in the series on Leading Better Care explores some of the challenges in clinical practice relating to the use of data and making information meaningful to senior charge nurses and ward sisters. It describes the collaborative approach taken by NHS Lanarkshire, which involved nursing staff, ... | ['Communication', 'Humans', 'Nursing Staff, Hospital', 'Nursing, Supervisory', 'Patient Handoff', 'Patient Safety', 'Patient-Centered Care', 'Practice Guidelines as Topic', 'Telemedicine', 'United Kingdom'] | 25,492,791 | [['F01.145.209', 'L01.143'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.526.485.680.490', 'M01.526.485.740.523', 'N02.360.680.490', 'N02.360.740.523'], ['N04.452.758.377.750'], ['E02.760.169.249', 'E02.760.400.615', 'N02.421.585.169.249', 'N02.421.585.400.615', 'N04.590.233.727.210.249', 'N05.715.840.500'],... | ['Psychiatry and Psychology [F]', 'Information Science [L]', 'Organisms [B]', 'Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 |
Evaluation of high frequency ultrasound methods and contrast agents for characterising tumor response to anti-angiogenic treatment. | PURPOSE: To compare non-enhanced and contrast-enhanced high-frequency 3D Doppler ultrasound with contrast-enhanced 2D and 3D B-mode imaging for assessing tumor vascularity during antiangiogenic treatment using soft-shell and hard-shell microbubbles.MATERIALS AND METHODS: Antiangiogenic therapy effects (SU11248) on vasc... | ['Angiogenesis Inhibitors', 'Animals', 'Carcinoma, Squamous Cell', 'Cell Line, Tumor', 'Contrast Media', 'Female', 'Imaging, Three-Dimensional', 'Mice', 'Mice, Nude', 'Microbubbles', 'Neovascularization, Pathologic', 'Reproducibility of Results', 'Sensitivity and Specificity', 'Treatment Outcome', 'Ultrasonography'] | 22,093,958 | [['D27.505.696.377.077.099', 'D27.505.696.377.450.100', 'D27.505.954.248.025'], ['B01.050'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['A11.251.210.190', 'A11.251.860.180'], ['D27.505.259.500', 'D27.720.259'], ['E01.370.350.400', 'L01.224.308.410'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.150.900.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Elevated [3H]inositol 1,4,5-trisphosphate binding sites and expressed inositol 1,4,5-trisphosphate receptor protein level in platelets of depressed patients. | Several reports suggest that serotonin2A (5HT2A) receptors and this receptor-mediated phosphatidyl inositol (PI) hydrolysis signal transduction system are altered in platelets of depressed patients. Inositol 1,4,5-trisphosphate (Ins[1,4,5]P3), an important component of the PI signaling system, plays a crucial role in v... | ['Adult', 'Blood Platelets', 'Calcium Channels', 'Depressive Disorder', 'Female', 'Humans', 'Inositol 1,4,5-Trisphosphate', 'Inositol 1,4,5-Trisphosphate Receptors', 'Male', 'Receptors, Cytoplasmic and Nuclear', 'Tritium'] | 9,694,526 | [['M01.060.116'], ['A11.118.188', 'A15.145.229.188'], ['D12.776.157.530.400.150', 'D12.776.543.550.450.150', 'D12.776.543.585.400.150'], ['F03.600.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.033.800.519.400.350', 'D09.853.519.400.350', 'D09.894.480.350'], ['D12.776.157.530.400.150.760', 'D12.776.543.5... | ['Named Groups [M]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Electrophoresis of water-insoluble leptospiral proteins and the taxonomy of Leptospira. | The cellular debris obtained after lysis of Leptospira were solubilized by sodium dodecyl sulfate and studied by polyacrylamide electrophoresis, comparing the molecular weight and relative concentration of the protein bands. The percentage similarity of 30 characteristic bands from 21 Leptospira strains, belonging to t... | ['Bacterial Proteins', 'Electrophoresis, Polyacrylamide Gel', 'Leptospira', 'Molecular Weight', 'Serotyping'] | 1,015,034 | [['D12.776.097'], ['E05.196.401.402', 'E05.301.300.319'], ['B03.440.400.425.475.475', 'B03.851.475.475'], ['G02.494'], ['E01.370.225.812.742', 'E01.370.225.875.150.125.890', 'E05.200.812.742', 'E05.200.875.150.125.890', 'E05.478.594.780']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Enantiomeric separation of liarozole on amylose chiral stationary phase]. | A high performance liquid chromatographic method was established for the enantiomeric separation of liarozole. Baseline chiral separation of liarozole was achieved under normal-phase chromatographic mode by the Chiralpak AD-H chiral stationary phase. The influences of the concentration and kind of organic solvent, the ... | ['Amylose', 'Buffers', 'Chromatography, High Pressure Liquid', 'Imidazoles', 'Stereoisomerism', 'Temperature'] | 19,160,771 | [['D09.301.915.361', 'D09.698.365.855.361'], ['D27.720.470.280'], ['E05.196.181.400.300'], ['D03.383.129.308'], ['G02.607.445.682'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.150.450', 'N06.230.300.100.725.710']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
The effect of AM noise on correlation phase-noise measurements. | We analyze the phase-noise measurement methods in which correlation and averaging is used to reject the background noise of the instrument. All the known methods make use of a mixer, used either as a saturated-phase detector or as a linear-synchronous detector. Unifortunately, AM noise is taken in through the power-to-... | ['Amplifiers, Electronic', 'Artifacts', 'Equipment Failure', 'Equipment Failure Analysis', 'Radio Waves', 'Statistics as Topic', 'Ultrasonography'] | 17,523,557 | [['E07.305.061'], ['E05.047'], ['E05.325'], ['E05.325.192'], ['G01.358.500.505.810', 'G01.750.250.810', 'G01.750.770.721'], ['E05.318.740', 'H01.548.832', 'N05.715.360.750', 'N06.850.520.830'], ['E01.370.350.850']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Implementation of a model of emergency care in an Australian hospital. | AIM: Emergency departments are characterised by a fast-paced, quick turnover and high acuity workload, therefore appropriate staffing is vital to ensure positive patient outcomes. Models of care are frameworks in which safe and effective patient-to-nurse ratios can be ensured. The aim of this study was to implement a s... | ['Adult', 'Australia', 'Emergency Medical Services', 'Emergency Nursing', 'Emergency Service, Hospital', 'Female', 'Humans', 'Male', 'Models, Organizational', 'Self Report'] | 29,125,259 | [['M01.060.116'], ['Z01.639.100', 'Z01.678.100.373'], ['N02.421.297'], ['H02.478.676.200', 'N02.421.533.200'], ['N02.278.216.500.968.336', 'N02.421.297.195', 'N04.452.442.452.422.336'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.670', 'N04.452.534'], ['E05.318.308.980.500', 'N05.715.360.300.800.500', 'N... | ['Named Groups [M]', 'Geographicals [Z]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
At-risk and heavy episodic drinking, motivation to change, and the development of alcohol dependence among men. | OBJECTIVE: The purpose of this study was to analyze whether general hospital inpatients with at-risk and heavy episodic drinking (ARHE) have a higher motivation to change drinking habits and a higher risk of developing alcohol dependence than individuals with at-risk drinking only (AR) or heavy episodic drinking only (... | ['Adult', 'Alcohol Drinking', 'Alcoholism', 'Diagnostic and Statistical Manual of Mental Disorders', 'Follow-Up Studies', 'Hospitals, General', 'Humans', 'Inpatients', 'Male', 'Middle Aged', 'Motivation', 'Regression Analysis', 'Risk Factors'] | 19,895,771 | [['M01.060.116'], ['F01.145.317.269'], ['C25.775.100.250', 'F03.900.100.350'], ['L01.453.245.945.200'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['N02.278.421.389'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.643.470'], ['M01.060.116.630'], ['F01.658', 'F01.... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Rapid activation of the alternative pathway of complement by extracorporeal membrane oxygenation. | Extracorporeal membrane oxygenation (ECMO) is an effective therapy for patients with severe respiratory distress syndromes. However, an inflammatory response has been observed with the use of this therapy. We measured complement activation in vivo in two adults receiving ECMO for acute respiratory distress syndrome (AR... | ['Adult', 'Biomarkers', 'Complement Activation', 'Complement C3b', 'Complement C4', 'Complement C4b', 'Enzyme-Linked Immunosorbent Assay', 'Extracorporeal Membrane Oxygenation', 'Fatal Outcome', 'Female', 'Humans', 'Inflammation', 'Male', 'Middle Aged', 'Peptide Fragments', 'Respiratory Distress Syndrome'] | 9,952,020 | [['M01.060.116'], ['D23.101'], ['G12.274'], ['D12.776.124.486.274.250.260'], ['D12.776.124.486.274.350'], ['D12.776.124.486.274.350.260'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['E02.880.301', 'E04.292.451'], ['E05.318.308.985.550.325', 'N01... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Effect of nicotine on spinal disc cells: a cellular mechanism for disc degeneration. | STUDY DESIGN: Experimental investigation to determine the effect of nicotine on intervertebral spinal disc nucleus pulposus (NP) cells cultured in vitro. OBJECTIVES.: To evaluate the effects of nicotine on cell proliferation, extracellular matrix production, and viability of NP cells in three-dimensional alginate const... | ['Alginates', 'Animals', 'Cattle', 'Cell Culture Techniques', 'Cell Division', 'Cell Survival', 'Cells, Cultured', 'Chondrocytes', 'Collagen Type I', 'Collagen Type II', 'DNA', 'Dose-Response Relationship, Drug', 'Extracellular Matrix', 'Extracellular Matrix Proteins', 'Glucuronic Acid', 'Glycosaminoglycans', 'Hexuroni... | 15,129,075 | [['D09.698.068'], ['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['E01.370.225.500.223', 'E05.200.500.265', 'E05.242.223', 'E05.481.500.249'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['G04.346'], ['A11.251'], ['A11.329.171'], ['D05.750.078.280.300.100', 'D12.776.860.300.250.300.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Electrophoretic mobility profiles of mouse leukemias: I. Electrophoresis of normal mouse thymus and lymph node cell populations. | Anodic electrophoretic mobility of thymocytes and lymph node cells from random-bred ICR Swiss mice was examined. Three cell populations were identified which differed in their surface charge as reflected in their distinct mean AEM and in their time of appearance during the course of life. The first electrophoretically ... | ['Animals', 'Cell Movement', 'Cell Separation', 'Electrophoresis', 'Lymph Nodes', 'Mice', 'Mice, Inbred ICR', 'Mice, Inbred Strains', 'Thymus Gland'] | 7,312,073 | [['B01.050'], ['G04.198', 'G07.568.500.180'], ['E01.370.225.500.363', 'E05.200.500.363', 'E05.242.363'], ['E05.196.401', 'E05.301.300'], ['A10.549.400', 'A15.382.520.604.412'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.510', 'B01.050.150.900.649.313.992.635.505.500.400.510'], ['B01.050.050.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Thermal supplementing soil nutrients through biocomposting of night-soil in the northwestern Indian Himalaya. | Agriculture is one of the prime activities of the hill people residing in the northwestern Indian Himalaya. However, poor soil fertility in these areas is a big hurdle to sustainable farming. The effects of washout of topsoil and its nutrients, year after year, due to the abundance of snowfall, avalanches, landslides a... | ['Agriculture', 'Bioreactors', 'Conservation of Natural Resources', 'Feces', 'Fertilizers', 'Humans', 'Hygiene', 'India', 'Soil'] | 17,490,873 | [['J01.040'], ['E07.115', 'J01.897.120.115'], ['J01.256', 'N06.230.080'], ['A12.459'], ['D27.720.031.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.547', 'N06.850.670'], ['Z01.252.245.393'], ['D20.721', 'G01.311.820', 'G16.500.275.815', 'N06.230.600']] | ['Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Geographicals [Z]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
Development and validation of a frailty index based on Australian Aged Care Assessment Program data. | OBJECTIVES: To develop and validate a frailty index, derived from aged care eligibility assessment data.DESIGN: Retrospective cohort study; analysis of the historical national cohort of the Registry of Senior Australians (ROSA).PARTICIPANTS: 903 996 non-Indigenous Australians aged 65 years or more, living in the commun... | ['Aged', 'Aged, 80 and over', 'Australia', 'Female', 'Frail Elderly', 'Frailty', 'Geriatric Assessment', 'Health Services for the Aged', 'Health Status Indicators', 'Humans', 'Male', 'Predictive Value of Tests', 'Program Evaluation', 'Proportional Hazards Models', 'ROC Curve', 'Reproducibility of Results', 'Risk Factor... | 32,776,351 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['Z01.639.100', 'Z01.678.100.373'], ['M01.060.116.100.540'], ['C23.550.359'], ['E05.318.308.225', 'I01.240.425.350', 'N01.224.425.350', 'N05.715.360.300.360', 'N06.850.505.400.425.350', 'N06.850.520.308.225'], ['N02.421.320'], ['E05.318.308.980.438.475', 'N05.715.360.300.8... | ['Named Groups [M]', 'Geographicals [Z]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
The PET18 locus of Saccharomyces cerevisiae: a complex locus containing multiple genes. | The basis of pleiotropy shown by the pet18 mutants of Saccharomyces cerevisiae (rho-0,KIL-0 and temperature sensitive growth) was examined by cloning the fragment which complements the defect in growth at 37 degrees C of the pet18 mutants. The cloned DNA could complement the defect in the maintenance of the killer plas... | ['Base Sequence', 'Blotting, Southern', 'Cloning, Molecular', 'DNA, Fungal', 'Genes, Fungal', 'Genetic Complementation Test', 'Molecular Sequence Data', 'Phenotype', 'Plasmids', 'Restriction Mapping', 'Saccharomyces cerevisiae', 'Temperature', 'Transformation, Genetic'] | 3,916,862 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.196.401.114', 'E05.301.300.087', 'E05.601.150'], ['E05.393.220'], ['D13.444.308.300'], ['G05.360.340.024.340.364.500', 'G05.360.340.358.024.500', 'G05.360.340.358.365.500'], ['E05.393.281.526'], ['L01.453.245.667'], ['G05.695'], ['G05.360.600'], ['E05.39... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Assessment of older drivers: relationships among on-road errors, medical conditions and test outcome. | PROBLEM: It is essential that driver licensing authorities have a valid and reliable system for evaluating older drivers' continuing competency; road tests are usually required as part of such a system. This study sought to find information about the nature of driving errors made during license review tests, and about ... | ['Accidents, Traffic', 'Age Factors', 'Aged', 'Aged, 80 and over', 'Automobile Driving', 'Geriatric Assessment', 'Humans', 'Licensure', 'Logistic Models', 'Middle Aged', 'Police', 'Psychomotor Performance', 'Referral and Consultation', 'Victoria'] | 14,636,664 | [['N06.850.135.392'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['I03.125'], ['E05.318.308.225', 'I01.240.425.350', 'N01.224.425.350', 'N05.715.360.300.360', 'N06.850.505.400.425.350', 'N06.850.520.308.225'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.706.110.510'... | ['Health Care [N]', 'Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Units for reporting the results of toxicological measurements. | A survey of hospital laboratories and current literature revealed that there is a considerable diversity of units employed for reporting the results of toxicological assays. Consideration is given to some of the problems and difficulties that arise from the use of SI units for reporting drug analyses, resulting from a ... | ['Humans', 'International System of Units', 'Pharmaceutical Preparations', 'Toxicology', 'Weights and Measures'] | 7,212,606 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.978.507'], ['D26'], ['H01.158.891', 'H02.884'], ['E05.978']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Enantioselective synthesis of N-Cbz-protected 6-amino-6-deoxymannose, -talose, and -gulose. | The enantioselective synthesis of three 6-amino-6-deoxy sugars has been achieved in six to eight steps from furfural. A sequence of diastereoselective oxidation and reduction reactions produced Cbz-protected 6-aminomannose from furfuryl alcohol 3. The incorporation of a Mitsunobu reaction into the reaction sequence all... | ['Amino Sugars', 'Glucosamine', 'Magnetic Resonance Spectroscopy', 'Rhamnose', 'Stereoisomerism'] | 11,720,564 | [['D09.067'], ['D09.067.342.531'], ['E05.196.867.519'], ['D09.254.799'], ['G02.607.445.682']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Characterization of cellular receptors for erythroid differentiation factor on murine erythroleukemia cells. | Erythroid differentiation factor (EDF), which is structurally related to transforming growth factor-beta family and induces differentiation of murine erythroleukemia cell clone F5-5, has been labeled with 125I to characterize its interaction with cellular receptors. Binding of 125I-EDF to F5-5 cells is time- and temper... | ['Activins', 'Animals', 'Binding, Competitive', 'Cell Differentiation', 'Cell Line', 'Growth Substances', 'Humans', 'Inhibins', 'Kinetics', 'Leukemia, Erythroblastic, Acute', 'Mice', 'Molecular Weight', 'Receptors, Cell Surface', 'Receptors, Growth Factor', 'Recombinant Proteins'] | 2,542,329 | [['D06.472.334.500', 'D06.472.699.009', 'D12.644.548.009', 'D12.776.395.022'], ['B01.050'], ['E05.196.080', 'G02.111.084', 'G02.111.570.120.309'], ['G04.152'], ['A11.251.210'], ['D27.505.696.377'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D06.472.334.968', 'D06.472.699.337', 'D12.644.548.387', 'D12.776.395.43... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
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