Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Structural requirements for hybridization at the 5'-position are different in á-l-LNA as compared to â-D-LNA. | The synthesis and biophysical evaluation of R and S-5'-Me-á-l-LNA nucleoside phosphoramidites and modified oligo-2'-deoxyribonucleotides is reported. Synthesis of the nucleoside phosphoramidites was accomplished in multi-gram quantities starting from diacetone glucose. The 5'-methyl group in the S configuration was int... | ['Animals', 'Biochemistry', 'Biophysics', 'Crystallography, X-Ray', 'Drug Design', 'Glucose', 'Mice', 'Models, Chemical', 'Molecular Conformation', 'Nucleic Acid Conformation', 'Nucleic Acid Hybridization', 'Nucleosides', 'Oligonucleotides', 'Organophosphorus Compounds', 'Stereoisomerism', 'Temperature'] | 22,153,935 | [['B01.050'], ['H01.158.201', 'H01.181.122'], ['H01.158.344', 'H01.671.100'], ['E05.196.309.742.225'], ['E05.290.500', 'H01.158.703.007.338.500', 'H01.181.466.338.500'], ['D09.947.875.359.448'], ['B01.050.150.900.649.313.992.635.505.500'], ['E05.599.495'], ['G02.111.570.820'], ['G02.111.570.820.486', 'G05.360.580'], ['... | ['Organisms [B]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
An investigation into the performance of an automated quality assurance and dosimetry system in diagnostic radiology. | A system has been developed to undertake automatic quality assurance and dosimetry for diagnostic radiology examinations. The accuracy and reproducibility of the measurements and calculations made by the system have been investigated in a laboratory study and compared with concurrent measurements of exposure parameters... | ['Humans', 'Microcomputers', 'Quality Control', 'Radiation Dosage', 'Radiography'] | 2,400,880 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.230.260.550'], ['J01.897.608'], ['E05.799.513', 'G01.750.740', 'N06.850.810.250'], ['E01.370.350.700']] | ['Organisms [B]', 'Information Science [L]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 |
[Regeneration of the rabbit sciatic nerve after its dissection and the use of various surgical methods]. | The method of stimulation electromyography and histological methods were used to study regeneration of the sciatic nerve of a rabbit after its division and joining with epineural and perineural sutures as well as by means of a vascular allograft. Successful regeneration of the nerve occurred in both types of sutures. I... | ['Animals', 'Arteries', 'Electromyography', 'Methods', 'Muscles', 'Nerve Fibers', 'Nerve Regeneration', 'Rabbits', 'Sciatic Nerve', 'Skin Temperature', 'Suture Techniques', 'Time Factors'] | 3,071,055 | [['B01.050'], ['A07.015.114'], ['E01.370.405.255', 'E01.370.530.255'], ['E05.581'], ['A02.633', 'A10.690'], ['A08.675.542', 'A11.671.501'], ['G11.561.585', 'G16.762.611'], ['B01.050.150.900.649.313.968.700'], ['A08.800.800.720.450.760'], ['G07.110.753', 'G13.750.844'], ['E04.987.775'], ['G01.910.857']] | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Production of lactic acid from paper sludge using acid-tolerant, thermophilic Bacillus coagulan strains. | Production of lactic acid from paper sludge was studied using thermophilic Bacillus coagulan strains 36D1 and P4-102B. More than 80% of lactic acid yield and more than 87% of cellulose conversion were achieved using both strains without any pH control due to the buffering effect of CaCO(3) in paper sludge. The addition... | ['Acids', 'Bacillus', 'Bioreactors', 'Biotechnology', 'Calcium Carbonate', 'Carbohydrates', 'Cellobiose', 'Cellulose', 'Fermentation', 'Hydrogen-Ion Concentration', 'Industrial Microbiology', 'Lactic Acid', 'Paper', 'Sewage', 'Time Factors'] | 19,577,925 | [['D01.029'], ['B03.300.390.400.158.218', 'B03.353.500.100.218', 'B03.510.100.100.218', 'B03.510.415.400.158.218', 'B03.510.460.410.158.218'], ['E07.115', 'J01.897.120.115'], ['H01.158.550', 'J01.897.120'], ['D01.146.275', 'D01.200.275.150.150', 'D01.578.200'], ['D09'], ['D09.698.365.180.180', 'D09.698.629.305.200', 'D... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Effects on birth weight of smoking, alcohol, caffeine, socioeconomic factors, and psychosocial stress. | OBJECTIVE: To investigate the effects of smoking, alcohol, and caffeine consumption and socio-economic factors and psychosocial stress on birth weight.DESIGN: Prospective population study.SETTING: District general hospital in inner London.PARTICIPANTS: A consecutive series of 1860 white women booking for delivery were ... | ['Adolescent', 'Adult', 'Alcohol Drinking', 'Birth Weight', 'Caffeine', 'Coffee', 'Female', 'Gestational Age', 'Humans', 'Infant, Newborn', 'London', 'Maternal Age', 'Pregnancy', 'Prospective Studies', 'Smoking', 'Socioeconomic Factors', 'Stress, Psychological', 'Tea'] | 2,496,859 | [['M01.060.057'], ['M01.060.116'], ['F01.145.317.269'], ['C23.888.144.186', 'E01.370.600.115.100.160.120.186', 'E05.041.124.160.750.149', 'G07.100.100.160.120.186', 'G07.345.249.314.120.186'], ['D03.132.960.175', 'D03.633.100.759.758.824.175'], ['D20.215.784.249', 'G07.203.100.325', 'J02.200.325'], ['G07.345.500.325.23... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Geographicals [Z]', 'Health Care [N]', 'Anthropology, Edu... | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
Potential diagnosis of Giardia lamblia infection through specific antibody detection in saliva. | Thirty six patients presenting with gastrointestinal symptoms were studied for the presence of specific anti-Giardia lamblia salivary IgA antibodies. Stool samples were examined for parasites especially G. lamblia by direct smear. Duodenal aspirate was examined for the parasite. Saliva samples were collected from each ... | ['Animals', 'Antibodies, Protozoan', 'Antigens, Protozoan', 'Child', 'Child, Preschool', 'Enzyme-Linked Immunosorbent Assay', 'Feces', 'Gastrointestinal Diseases', 'Giardia lamblia', 'Giardiasis', 'Humans', 'Immunoglobulin A', 'Saliva'] | 15,287,184 | [['B01.050'], ['D12.776.124.486.485.114.252', 'D12.776.124.790.651.114.252', 'D12.776.377.715.548.114.252'], ['D23.050.293'], ['M01.060.406'], ['M01.060.406.448'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['A12.459'], ['C06.405'], ['B01.237.385... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Alternative polyadenylation of Pax3 controls muscle stem cell fate and muscle function. | Adult stem cells are essential for tissue homeostasis. In skeletal muscle, muscle stem cells (MuSCs) reside in a quiescent state, but little is known about the mechanisms that control homeostatic turnover. Here we show that, in mice, the variation in MuSC activation rate among different muscles (for example, limb versu... | ["3' Untranslated Regions", 'Animals', 'Gene Knockdown Techniques', 'Mice', 'Mice, Mutant Strains', 'MicroRNAs', 'Muscle, Skeletal', 'Myoblasts, Skeletal', 'PAX3 Transcription Factor', 'Polyadenylation', 'RNA, Messenger', 'Ribonucleoprotein, U1 Small Nuclear'] | 31,699,935 | [['D13.444.735.544.875.880', 'D13.444.735.790.878.880', 'G05.360.340.024.220.880.880', 'G05.360.340.024.340.137.910.880'], ['B01.050'], ['E05.393.335.500'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.150.900.649.313.992.635.505.500.550'], ['D13.150.650.319', 'D13.444.735.150.319', 'D13.444.735.790.552.500']... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Construction of a gene bank of Rhizobium leguminosarum Rld 164. | The total genomic DNA of R. leguminosarum Rld164 (trp, sms, azi) was cloned in the EcoR1 site of the wide host and conjugally transferable cosmid vector pLAFR1. The average insert size in the gene clones of the bank was found to be 21.3 Kb. The strain R. leguminosarum Rld7 (leu-1) was employed as recepient to conjugall... | ['Cloning, Molecular', 'DNA, Bacterial', 'Gene Library', 'Genes, Bacterial', 'Rhizobium'] | 2,606,538 | [['E05.393.220'], ['D13.444.308.212'], ['G05.360.325'], ['G05.360.340.024.340.364.249', 'G05.360.340.358.024.249', 'G05.360.340.358.207.249'], ['B03.440.400.425.700.800', 'B03.585.900', 'B03.660.050.662.670']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Agency and dependency within treatment: drug treatment clients negotiating methadone and antidepressants. | This paper explores how drug treatment clients exercise agency while finding their ability to act curtailed by the strictures of treatment itself. Drawing on qualitative interviews with 77 male and female drug treatment clients collected in an Australian study of drug treatment and mental health, the experience of meth... | ['Adult', 'Antidepressive Agents', 'Female', 'Humans', 'Interviews as Topic', 'Male', 'Methadone', 'New South Wales', 'Patient Compliance', 'Substance-Related Disorders'] | 17,321,658 | [['M01.060.116'], ['D27.505.954.427.700.122'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.420', 'L01.399.250.520', 'N05.715.360.300.400', 'N06.850.520.308.420'], ['D02.522.675'], ['Z01.639.100.750', 'Z01.678.100.373.750'], ['F01.100.150.750.500.600', 'F01.145.488.887.500.600', 'N05.300.150.800.500.6... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
Plant roots redesign the rhizosphere to alter the three-dimensional physical architecture and water dynamics. | The mechanisms controlling the genesis of rhizosheaths are not well understood, despite their importance in controlling the flux of nutrients and water from soil to root. Here, we examine the development of rhizosheaths from drought-tolerant and drought-sensitive chickpea varieties; focusing on the three-dimensional ch... | ['Cicer', 'Droughts', 'Permeability', 'Plant Roots', 'Porosity', 'Quantitative Trait, Heritable', 'Rhizosphere', 'Soil', 'Water', 'X-Ray Microtomography'] | 29,774,952 | [['B01.650.940.800.575.912.250.401.150'], ['G16.500.175.781', 'G16.500.750.775.154', 'N06.230.100.230.150'], ['G02.723'], ['A18.400'], ['G01.374.710'], ['G05.420.720'], ['G16.500.275.157.625', 'G16.500.853', 'N06.230.124.437'], ['D20.721', 'G01.311.820', 'G16.500.275.815', 'N06.230.600'], ['D01.045.250.875', 'D01.248.4... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Spirochetes isolated from the blood of two patients with Lyme disease. | We isolated spirochetes from the blood of 2 of 36 patients in Long Island and Westchester County, New York, who had signs and symptoms suggestive of Lyme disease. The spirochetes were morphologically similar and serologically identical to organisms recently found to infect lxodes dammini ticks, which are endemic to the... | ['Adult', 'Aged', 'Antibodies, Bacterial', 'Arthritis, Infectious', 'Blood', 'Female', 'Humans', 'Male', 'New York', 'Spirochaetales', 'Spirochaetales Infections', 'Tick Infestations'] | 6,828,119 | [['M01.060.116'], ['M01.060.116.100'], ['D12.776.124.486.485.114.107', 'D12.776.124.790.651.114.125', 'D12.776.377.715.548.114.125'], ['C01.100', 'C05.550.114.099'], ['A12.207.152', 'A15.145'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.107.567.875.075.437', 'Z01.107.567.875.350.530', 'Z01.107.567.875.500.5... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Geographicals [Z]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
Application of Single Voxel 1H Magnetic Resonance Spectroscopy in Hepatic Benign and Malignant Lesions. | BACKGROUND To quantify the metabolite changes in hepatic tumors by single-voxel 1H magnetic resonance spectroscopy (MRS) at 3.0 T and explore the application value of 1HMRS in the diagnosis of hepatic benign and malignant lesions. MATERIAL AND METHODS A total of 45 patients (55 lesions) diagnosed with hepatic lesions b... | ['Adult', 'Aged', 'Choline', 'Contrast Media', 'Diagnosis, Differential', 'Female', 'Humans', 'Lipid Metabolism', 'Liver Neoplasms', 'Magnetic Resonance Imaging', 'Magnetic Resonance Spectroscopy', 'Male', 'Middle Aged'] | 27,992,399 | [['M01.060.116'], ['M01.060.116.100'], ['D02.033.100.291.211', 'D02.092.063.291.211', 'D02.092.877.883.333', 'D02.675.276.232'], ['D27.505.259.500', 'D27.720.259'], ['E01.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G03.458'], ['C04.588.274.623', 'C06.301.623', 'C06.552.697'], ['E01.370.350.825.500'], ['E0... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Suppression of 6-Hydroxydopamine-Induced Oxidative Stress by Hyperoside Via Activation of Nrf2/HO-1 Signaling in Dopaminergic Neurons. | In our ongoing research to discover natural products with neuroprotective effects, hyperoside (quercetin 3-O-galactoside) was isolated from Acer tegmentosum, which has been used in Korean traditional medicine to treat liver-related disorders. Here, we demonstrated that hyperoside protects cultured dopaminergic neurons ... | ['Acer', 'Antioxidants', 'Cell Line, Tumor', 'Dopaminergic Neurons', 'Heme Oxygenase-1', 'Humans', 'NF-E2-Related Factor 2', 'Neuroprotective Agents', 'Oxidative Stress', 'Oxidopamine', 'Quercetin', 'Signal Transduction'] | 31,757,050 | [['B01.650.940.800.575.912.250.885.056'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['A11.251.210.190', 'A11.251.860.180'], ['A08.675.278', 'A11.671.270'], ['D08.811.682.690.708.410.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.260.108.737', 'D12.776.930.127.737'], ['D27.505.696... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Biological responses to trauma and the development of intrusive memories: an analog study with the trauma film paradigm. | Evidence suggests that previous trauma reduces the cortisol response to subsequent stressors. We examined the relation of this response to intrusive memory, and the potential moderating roles of sympathetic reactions. Pre-existing trauma-related factors and the cardiac defense response were assessed before 58 healthy p... | ['Adolescent', 'Adult', 'Female', 'Humans', 'Hydrocortisone', 'Male', 'Memory', 'Saliva', 'Salivary alpha-Amylases', 'Stress Disorders, Post-Traumatic', 'Sympathetic Nervous System', 'Young Adult'] | 25,150,464 | [['M01.060.057'], ['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D04.210.500.745.745.654.600', 'D06.472.040.585.353.476', 'D06.472.040.585.478.392'], ['F02.463.425.540'], ['A12.200.666'], ['D08.811.277.450.066.050.500', 'D12.644.848.875', 'D12.776.850.887'], ['F03.950.750.500'], ['A08.800.050.800']... | ['Named Groups [M]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The measurement of antibodies to extractable nuclear antigen. | By the use of a combination of Ouchterlony immunodiffusion and hemagglutination, it was found that 30 of 81 sera (37%) from patients who had systemic lupus erythematosus (SLE) had antibodies to the ribonucleoprotein component of extractable nuclear antigen, and 37 (46%) had antibody to the Sm antigen. Immunodiffusion w... | ['Antibodies, Antinuclear', 'Hemagglutination Tests', 'Humans', 'Immunodiffusion', 'Lupus Erythematosus, Systemic', 'Nucleoproteins', 'Ribonucleoproteins'] | 107,791 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Frictional properties of confined polymers. | We present molecular dynamics friction calculations for confined hydrocarbon solids with molecular lengths from 20 to 1400 carbon atoms. Two cases are considered: a) polymer sliding against a hard substrate, and b) polymer sliding on polymer. In the first setup the shear stresses are relatively independent of molecular... | ['Carbon', 'Computer Simulation', 'Elasticity', 'Equipment Design', 'Friction', 'Models, Theoretical', 'Physics', 'Polymers', 'Pressure', 'Stress, Mechanical', 'Surface Properties'] | 19,230,226 | [['D01.268.150'], ['L01.224.160'], ['G01.374.590'], ['E05.320'], ['G01.374.618'], ['E05.599'], ['H01.671'], ['D05.750', 'D25.720', 'J01.637.051.720'], ['G01.374.715'], ['G01.374.835'], ['G02.860']] | ['Chemicals and Drugs [D]', 'Information Science [L]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 |
Alloxan- and glutathione-dependent ferritin iron release and lipid peroxidation. | The diabetogenic action of alloxan is believed to involve oxygen free radicals and iron. Incubation of glutathione (GSH) and alloxan with rat liver ferritin resulted in release of ferrous iron as assayed by spectrophotometric detection of ferrous-bathophenanthroline complex formation. Neither GSH nor alloxan alone medi... | ['Alloxan', 'Animals', 'Catalase', 'Ceruloplasmin', 'Electron Spin Resonance Spectroscopy', 'Ferritins', 'Free Radicals', 'Glutathione', 'Iron', 'Kinetics', 'Lipid Peroxidation', 'Liver', 'Rats', 'Superoxide Dismutase'] | 2,537,598 | [['D03.383.742.698.122'], ['B01.050'], ['D08.811.682.732.332'], ['D08.811.682.226', 'D12.776.124.050.130', 'D12.776.124.790.106.214', 'D12.776.157.160', 'D12.776.377.715.085.214', 'D12.776.556.151'], ['E05.196.867.519.274'], ['D12.776.157.427.249', 'D12.776.556.579.249'], ['D01.339', 'D02.389'], ['D12.644.456.448'], ['... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Role of nitric oxide-related mechanisms in renal function in ageing rats. | BACKGROUND: The impaired renal function and vasodilatation that accompany age need to be re-addressed based upon the new knowledge concerning vascular nitric oxide (NO)-dependent systems. The present study examined the effects of age on the NO-related renal response.METHODS: The study was performed in euvolaemic, consc... | ['Acetylcholine', 'Aging', 'Animals', 'Antihypertensive Agents', 'Arginine', 'Glomerular Filtration Rate', 'Hemodynamics', 'Kidney', 'Kidney Function Tests', 'Male', 'Microspheres', 'Nitric Oxide', 'Nitroprusside', 'Rats', 'Rats, Wistar'] | 9,550,633 | [['D02.092.211.111'], ['G07.345.124'], ['B01.050'], ['D27.505.954.411.162'], ['D12.125.068.050', 'D12.125.095.104', 'D12.125.142.087'], ['E01.370.390.400.300', 'G08.852.357'], ['G09.330.380'], ['A05.810.453'], ['E01.370.390.400'], ['E07.565'], ['D01.339.387', 'D01.625.550.500', 'D01.625.700.500', 'D01.650.550.587.600']... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Detection of autoantibodies to thyroid peroxidase in autoimmune thyroid diseases by micro-ELISA and immunoblotting. | Serum autoantibodies to thyroid peroxidase (TPO) in patients with thyroid autoimmune diseases were studied by micro-ELISA and immunoblotting. Twenty-four patients, 15 with Graves' disease and 9 with Hashimoto's thyroiditis, whose serum titers were greater than 3200 on the microsomal hemagglutination test (except for 1 ... | ['Animals', 'Autoantibodies', 'Autoimmune Diseases', 'Binding, Competitive', 'Collodion', 'Electrophoresis, Polyacrylamide Gel', 'Enzyme-Linked Immunosorbent Assay', 'Hemagglutination Tests', 'Humans', 'Immunochemistry', 'Immunoglobulin G', 'Iodide Peroxidase', 'Microsomes', 'Rabbits', 'Swine', 'Thyroid Diseases', 'Thy... | 3,958,129 | [['B01.050'], ['D12.776.124.486.485.114.323', 'D12.776.124.790.651.114.323', 'D12.776.377.715.548.114.323'], ['C20.111'], ['E05.196.080', 'G02.111.084', 'G02.111.570.120.309'], ['D25.720.099.500.439', 'J01.637.051.720.099.500.439'], ['E05.196.401.402', 'E05.301.300.319'], ['E05.478.566.350.170', 'E05.478.566.380.360', ... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Disciplines and Occupations [H]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Clinical characteristics and risk factors associated with COVID-19 disease severity in patients with cancer in Wuhan, China: a multicentre, retrospective, cohort study. | BACKGROUND: COVID-19 has spread globally. Epidemiological susceptibility to COVID-19 has been reported in patients with cancer. We aimed to systematically characterise clinical features and determine risk factors of COVID-19 disease severity for patients with cancer and COVID-19.METHODS: In this multicentre, retrospect... | ['Aged', 'Betacoronavirus', 'COVID-19', 'China', 'Cities', 'Coronavirus Infections', 'Female', 'Hospitalization', 'Humans', 'Male', 'Middle Aged', 'Neoplasms', 'Pandemics', 'Pneumonia, Viral', 'Retrospective Studies', 'Risk Factors', 'SARS-CoV-2', 'Severity of Illness Index'] | 32,479,790 | [['M01.060.116.100'], ['B04.820.578.500.540.150.113'], ['C01.748.214', 'C01.748.610.763.500', 'C01.925.705.500', 'C01.925.782.600.550.200.163', 'C08.381.677.807.500', 'C08.730.214', 'C08.730.610.763.500'], ['Z01.252.474.164'], ['G16.500.275.069', 'N06.230.069', 'Z01.433'], ['C01.925.782.600.550.200'], ['E02.760.400', '... | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Cancer genetic clinics: why do women who already have cancer attend? | Cancer patients attend oncogenetic clinics so that the existence of a genetic risk can be checked and the relatives informed. The aim of this study was to describe the expectations of cancer patients about genetic counselling and their beliefs about the aetiology of their disease. A survey based on self-administered qu... | ['Attitude to Health', 'Breast Neoplasms', 'Cancer Care Facilities', 'Female', 'France', 'Genetic Counseling', 'Humans', 'Middle Aged', 'Ovarian Neoplasms', 'Patient Acceptance of Health Care', 'Patient Satisfaction', 'Referral and Consultation', 'Risk Factors'] | 9,893,626 | [['F01.100.150', 'N05.300.150'], ['C04.588.180', 'C17.800.090.500'], ['N02.278.421.556.070'], ['Z01.542.286'], ['H01.158.273.343.385.500.384', 'N02.421.308.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C04.588.322.455', 'C13.351.500.056.630.705', 'C13.351.937.418.685', 'C19.344.410', 'C... | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Diseases [C]', 'Geographicals [Z]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
The impact of Alpha/ESHRE consensus regarding oocytes with aggregates of smooth endoplasmic reticulum (SERa) on in vitro fertilization outcome. | PURPOSE: The present study aimed to gather information on the impact of Alpha/European Society of Human Reproduction and Embryology (ESHRE) consensus regarding oocytes with aggregates of smooth endoplasmic reticulum (SERa) on in vitro fertilization outcome. In particular, we investigated if patients undergoing intracyt... | ['Adult', 'Case-Control Studies', 'Embryo Implantation', 'Embryo Transfer', 'Endoplasmic Reticulum, Smooth', 'Female', 'Humans', 'Male', 'Oocytes', 'Practice Guidelines as Topic', 'Pregnancy', 'Pregnancy Rate', 'Sperm Injections, Intracytoplasmic'] | 26,431,954 | [['M01.060.116'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['G08.686.784.170.104.500'], ['E02.875.800.500', 'E05.820.800.500'], ['A11.284.430.214.190.875.248.310'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A05.360.490.690.680', 'A11.497.497.600'], ['N04.761.700.350.650', ... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
NH4(+) triggers the release of astrocytic lactate via mitochondrial pyruvate shunting. | Neural activity is accompanied by a transient mismatch between local glucose and oxygen metabolism, a phenomenon of physiological and pathophysiological importance termed aerobic glycolysis. Previous studies have proposed glutamate and K(+) as the neuronal signals that trigger aerobic glycolysis in astrocytes. Here we ... | ['Ammonium Compounds', 'Animals', 'Astrocytes', 'Lactic Acid', 'Mice', 'Mitochondria', 'Pyruvic Acid'] | 26,286,989 | [['D01.625.062'], ['B01.050'], ['A08.637.200', 'A11.650.200'], ['D02.241.511.459.450'], ['B01.050.150.900.649.313.992.635.505.500'], ['A11.284.430.214.190.875.564', 'A11.284.835.626'], ['D02.241.755.812.800']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Eustachian tube blockage and Meniere's disease. | On the basis of our clinical experience, it has been noted that an unusually large proportion of patients with Meniere's disease have intermittent eustachian tube blockage. A review of the tympanograms of 81 patients with Meniere's disease, representing 107 ears, showed that 25 (30.9%) of the patients and 35 (32.7%) of... | ['Adult', 'Aged', 'Air Pressure', 'Ear Canal', 'Ear Diseases', 'Eustachian Tube', 'Humans', 'Meniere Disease', 'Middle Aged'] | 869,771 | [['M01.060.116'], ['M01.060.116.100'], ['G16.500.750.274.100', 'N06.230.300.100.185.100'], ['A09.246.272.396'], ['C09.218'], ['A09.246.397.369'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C09.218.568.217.500'], ['M01.060.116.630']] | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Cycloalkanones V: synthesis, distribution, and effects on triglyceride metabolism. | The 14-C-labeled 2,8-dibenzylcyclooctanone was synthesized to study its absorption, distribution, and excretion in rats. Maximum drug absorption from the GI tract occurred between 12 and 14 hr after administration. The major organs possessed maximum amounts of the drug in 1 hr, with the liver concentrating the most wit... | ['Acid Phosphatase', 'Acyltransferases', 'Animals', 'Benzyl Compounds', 'Carbon Radioisotopes', 'Cycloparaffins', 'Dihydroxyacetone Phosphate', 'Glycerol-3-Phosphate O-Acyltransferase', 'In Vitro Techniques', 'Intestinal Absorption', 'Lipase', 'Lipids', 'Liver', 'Male', 'Microsomes, Liver', 'Organ Size', 'Phosphoric Mo... | 165,282 | [['D08.811.277.352.650.025'], ['D08.811.913.050'], ['B01.050'], ['D02.455.426.559.389.140'], ['D01.268.150.075.328', 'D01.496.123.328', 'D01.496.749.154'], ['D02.455.426.392.368', 'D04.345.133'], ['D09.894.150'], ['D08.811.913.050.425'], ['E05.481'], ['G03.015.500.374.500', 'G03.787.024.500.374.500', 'G07.203.650.372.5... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Malignant mesenchymoma of median nerve: combined nerve sheath sarcoma and liposarcoma. | A malignant mesenchymoma consisting of nerve sheath sarcoma and liposarcoma occurred in the right median nerve of a 29-year-old man who did not have stigmata of von Recklinghausen neurofibromatosis. It produced pain at the affected part, referred pain to the palm, and weakness of muscles supplied by branches of this ne... | ['Adipose Tissue', 'Adult', 'Humans', 'Liposarcoma', 'Lung Neoplasms', 'Male', 'Median Nerve', 'Myelin Sheath', 'Neoplasm Recurrence, Local', 'Peripheral Nervous System Neoplasms', 'Sarcoma'] | 6,694,400 | [['A10.165.114'], ['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.557.450.550.420', 'C04.557.450.795.465'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['A08.800.800.720.050.500'], ['A08.637.600.500', 'A08.637.800.500', 'A08.675.542.512.560', 'A08.800.800.690.500', 'A10.755.503', 'A11... | ['Anatomy [A]', 'Named Groups [M]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Effect of a novel beta-adrenoceptor agonist (Ro 40-2148) on resting energy expenditure in obese women. | The aim of this single-blind, placebo-controlled study was to investigate the effects of the new beta-adrenergic compound Ro 40-2148 on resting energy expenditure (REE) at rest and after an oral glucose load in non-diabetic obese women before and after two weeks of treatment. After one week of placebo administration an... | ['Adrenergic beta-Agonists', 'Adult', 'Blood Glucose', 'Body Temperature Regulation', 'C-Peptide', 'Calorimetry, Indirect', 'Energy Metabolism', 'Female', 'Glucose', 'Glucose Tolerance Test', 'Hemodynamics', 'Humans', 'Insulin', 'Lipid Metabolism', 'Middle Aged', 'Obesity', 'Organic Chemicals', 'Oxidation-Reduction', '... | 7,914,795 | [['D27.505.519.625.050.100.200', 'D27.505.696.577.050.100.200'], ['M01.060.116'], ['D09.947.875.359.448.500'], ['G07.110.232', 'G07.410.421', 'G16.012.500.535'], ['D06.472.699.587.200.500.250', 'D12.644.548.586.200.500.250'], ['E05.196.131.655'], ['G03.295'], ['D09.947.875.359.448'], ['E01.370.225.124.100.355', 'E01.37... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Factors influencing the stability of alpha-helices and beta-strands in thermophilic ribonuclease H. | Understanding the influence of structural parameters is crucial to enhance the thermal stability of proteins. In this work, the stability (deltaG) of residues in different secondary structures of Ribonuclease H (RNase H) has been analyzed with 48 amino acid properties. The properties reflecting hydrophobicity show a go... | ['Enzyme Stability', 'Hot Temperature', 'Models, Molecular', 'Protein Conformation', 'Protein Structure, Secondary', 'Ribonuclease H', 'Solvents', 'Thermus thermophilus'] | 11,426,698 | [['E05.916.360', 'G02.111.700.500'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.775.710.380', 'N06.230.300.100.725.232', 'N06.230.300.100.725.710.380'], ['E05.599.595'], ['G02.111.570.820.709'], ['G02.111.570.820.709.600'], ['D08.811.277.352.355.350.700', 'D08.811.277.352.700.350.700'], ['D27.720.8... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Electrochemical nanoprobes for single-cell analysis. | The measurement of key molecules in individual cells with minimal disruption to the biological milieu is the next frontier in single-cell analyses. Nanoscale devices are ideal analytical tools because of their small size and their potential for high spatial and temporal resolution recordings. Here, we report the fabric... | ['Electrochemical Techniques', 'Electrodes', 'Hydrogen Peroxide', 'Microscopy, Electron, Scanning', 'Nanostructures', 'Oxidation-Reduction', 'Oxygen', 'Single-Cell Analysis'] | 24,377,306 | [['E05.301'], ['E07.305.250'], ['D01.248.497.158.685.750.424', 'D01.339.431.374.424', 'D01.650.550.750.400', 'D02.389.338.253'], ['E01.370.350.515.402.541', 'E05.595.402.541'], ['J01.637.512'], ['G02.700', 'G03.295.531'], ['D01.268.185.550', 'D01.362.670'], ['E05.242.900']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Does the ADMA/DDAH/NO pathway modulate early regression of left ventricular hypertrophy with esmolol? | Hypertensive left ventricular hypertrophy (LVH) is a maladaptive response to chronic pressure overload and a strong independent risk factor for cardiovascular disease. Regression of LVH is associated with improved prognosis. Regression of LVH with antihypertensive therapy (angiotensin-converting enzyme inhibitors, angi... | ['Adrenergic beta-1 Receptor Antagonists', 'Amidohydrolases', 'Animals', 'Antihypertensive Agents', 'Arginine', 'Humans', 'Hypertension', 'Hypertrophy, Left Ventricular', 'Models, Cardiovascular', 'Nitric Oxide', 'Propanolamines', 'Rats', 'Rats, Inbred SHR', 'Risk Factors', 'Signal Transduction', 'Ventricular Remodelin... | 26,826,640 | [['D27.505.519.625.050.200.200.100', 'D27.505.696.577.050.200.200.100'], ['D08.811.277.087'], ['B01.050'], ['D27.505.954.411.162'], ['D12.125.068.050', 'D12.125.095.104', 'D12.125.142.087'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['C14.280.195.400', 'C23.300.775.250.400'], ['E05.599.395.161']... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Investigation of a dosage regimen for intravenous theophylline. | A study was designed to evaluate the validity of the dosage guidelines for theophylline recommended by Hendeles and Weinberger. A total of seven asthmatic smokers and non-smokers were entered and studied. Theophylline serum concentrations were determined prior to the start of therapy and at intervals following initiati... | ['Adult', 'Asthma', 'Drug Administration Schedule', 'Half-Life', 'Humans', 'Infusions, Parenteral', 'Injections, Intravenous', 'Kinetics', 'Middle Aged', 'Theophylline'] | 7,067,620 | [['M01.060.116'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['E02.319.283'], ['G01.910.405'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.267.510'], ['E02.319.267.082.750', 'E02.319.267.530.540'], ['G01.374.661', 'G02.111.490'], ['M01.060.116.630'], ['D03.132.960.751', 'D0... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Usefulness and application of the liver hanging maneuver for anatomical liver resections. | BACKGROUND: To achieve complete anatomic hepatectomy, hepatic transection by an anterior approach is useful. The liver hanging maneuver is a useful procedure for transection of adequate cut plane in anatomical liver resections and may reduce intraoperative bleeding and transection time.METHODS: We examined the records ... | ['Adult', 'Aged', 'Aged, 80 and over', 'Analysis of Variance', 'Chi-Square Distribution', 'Female', 'Hepatectomy', 'Humans', 'Liver', 'Liver Diseases', 'Liver Function Tests', 'Male', 'Middle Aged', 'Treatment Outcome'] | 18,452,024 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['E04.210.556'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A03.620'], ['C06.552'], ['E... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Acute angle closure glaucoma after sertraline. | Glaucoma is a rare complication of selective serotonin reuptake inhibitor treatment. We report a case of acute angle closure glaucoma related to sertraline. | ['Acute Disease', 'Depressive Disorder, Major', 'Female', 'Glaucoma, Angle-Closure', 'Humans', 'Middle Aged', 'Serotonin Uptake Inhibitors', 'Sertraline'] | 23,040,863 | [['C23.550.291.125'], ['F03.600.300.375'], ['C11.525.381.056'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['D27.505.519.562.437.850', 'D27.505.519.625.600.850', 'D27.505.519.625.850.900', 'D27.505.696.577.600.850', 'D27.505.696.577.850.900'], ['D02.092.705.800', 'D02.455.426.559.847.638.845.... | ['Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Named Groups [M]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A soxRS-constitutive mutation contributing to antibiotic resistance in a clinical isolate of Salmonella enterica (Serovar typhimurium). | The soxRS regulon is activated by redox-cycling drugs such as paraquat and by nitric oxide. The >15 genes of this system provide resistance to both oxidants and multiple antibiotics. An association between clinical quinolone resistance and elevated expression of the soxRS regulon has been observed in Escherichia coli, ... | ['Anti-Bacterial Agents', 'Anti-Infective Agents', 'Blotting, Northern', 'Chloramphenicol', 'Ciprofloxacin', 'Drug Resistance, Microbial', 'Genes, Bacterial', 'Humans', 'Microbial Sensitivity Tests', 'Mutation', 'Nalidixic Acid', 'Phenotype', 'Plasmids', 'Salmonella Infections', 'Salmonella enterica', 'Tetracyclines'] | 11,120,941 | [['D27.505.954.122.085'], ['D27.505.954.122'], ['E05.196.401.095', 'E05.301.300.074', 'E05.601.100'], ['D02.033.455.706.300', 'D02.455.426.559.389.565.175', 'D02.640.529.175'], ['D03.633.100.810.835.322.186'], ['G06.225', 'G07.690.773.984.269'], ['G05.360.340.024.340.364.249', 'G05.360.340.358.024.249', 'G05.360.340.35... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
M2BP inhibits HIV-1 virion production in a vimentin filaments-dependent manner. | M2BP (also called 90K) is an interferon-stimulated gene product that is upregulated in HIV-1 infection. A recent study revealed that M2BP reduces the infectivity of HIV-1 by inhibiting the processing of the viral envelope protein. Here we report that in addition to reducing viral infectivity, M2BP inhibits HIV-1 virion... | ['Antigens, Neoplasm', 'Biomarkers, Tumor', 'Carrier Proteins', 'Cell Line', 'Cell Membrane', 'Glycoproteins', 'HIV-1', 'HeLa Cells', 'Host-Pathogen Interactions', 'Humans', 'Interferon alpha-2', 'Interferon-alpha', 'Recombinant Proteins', 'Vimentin', 'Virion', 'Virus Replication', 'env Gene Products, Human Immunodefic... | 27,604,950 | [['D23.050.285'], ['D23.101.140'], ['D12.776.157'], ['A11.251.210'], ['A11.284.149'], ['D09.400.430', 'D12.776.395'], ['B04.820.650.589.650.350.400'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'], ['G06.462', 'G16.527.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.440.890.250... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Asymmetric synthesis of (S)-alpha-methylbenzylamine by recombinant Escherichia coli co-expressing omega-transaminase and acetolactate synthase. | To produce (S)-alpha-methylbenzylamine (MBA) from acetophenone, recombinant Escherichia coli co-expressing omega-transaminase and acetolactate synthase was used as a whole-cell biocatalyst. The solvent-bridge reaction system increased the yield of the whole-cell reaction by 2.5-fold, and the inhibitory (S)-alpha-MBA pr... | ['Acetolactate Synthase', 'Biocatalysis', 'DNA, Recombinant', 'Escherichia coli', 'Gene Expression', 'Phenethylamines', 'Solvents', 'Stereoisomerism', 'Transaminases'] | 18,997,410 | [['D08.811.913.200.324', 'D12.776.331.049'], ['G02.111.086', 'G02.130.500', 'G03.105'], ['D13.444.308.460'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['G05.297'], ['D02.092.471.683'], ['D27.720.844'], ['G02.607.445.682'], ['D08.811.913.477.700']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Analysis of age-period-cohort effect on breast cancer mortality in Brazil and regions]. | OBJECTIVE: To estimate the effect of age, period and birth cohort on mortality from breast cancer in Brazil and regions.METHODS: Data on mortality from breast cancer were analyzed for women aged > 30 years in Brazil and regions from 1980 to 2009. The effect of age, period, and birth cohort was calculated by Poisson reg... | ['Adult', 'Age Factors', 'Aged', 'Aged, 80 and over', 'Brazil', 'Breast Neoplasms', 'Female', 'Geography, Medical', 'Humans', 'Middle Aged', 'Mortality'] | 26,245,175 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['Z01.107.757.176'], ['C04.588.180', 'C17.800.090.500'], ['H01.277.500.097', 'H02.403.352'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.308.985.550', 'N01.224.935.698', 'N06.850.5... | ['Named Groups [M]', 'Health Care [N]', 'Geographicals [Z]', 'Diseases [C]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
The collaboration of grouping laws in vision. | Gestalt theory gives a list of geometric grouping laws that could in principle give a complete account of human image perception. Based on an extensive thesaurus of clever graphical images, this theory discusses how grouping laws collaborate, and conflict toward a global image understanding. Unfortunately, as shown in ... | ['Algorithms', 'Gestalt Theory', 'Humans', 'Mathematics', 'Models, Biological', 'Psychophysics', 'Vision, Ocular', 'Visual Perception'] | 22,343,519 | [['G17.035', 'L01.224.050'], ['F02.739.527'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H01.548'], ['E05.599.395'], ['E01.370.685', 'F04.096.753'], ['F02.830.816.964', 'G02.111.820.480.900', 'G04.835.480.900', 'G11.561.790.964', 'G14.935'], ['F02.463.593.932']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Strategies for developing a family support group. | Various interventions may be used by nurses to provide social support to critical care families. Nurses may support family members in one-to-one relationships, or by facilitating the development of supportive relationships in the group setting. The steps described here are fundamental in developing a support group for ... | ['Anxiety', 'Critical Care', 'Family', 'Group Processes', 'Group Structure', 'Humans', 'Nursing Diagnosis', 'Self-Help Groups', 'Social Isolation', 'Social Support'] | 1,761,127 | [['F01.470.132'], ['E02.760.190', 'N02.421.585.190'], ['F01.829.263', 'I01.880.853.150'], ['F01.829.316'], ['F01.829.316.274'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N04.590.233.508.480.110'], ['N03.540.782'], ['F01.145.813.781', 'I01.880.853.748'], ['I01.880.853.500.600']] | ['Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Rectal plasmacytoma with intracellular hemosiderin in a dog. | An 11-year-old female American Cocker Spaniel was presented with a rectal mass that protruded through the anus. Cytologically, the mass was composed of neoplastic round cells consistent with an extramedullary plasmacytoma. Histiocytic sarcoma, carcinoid tumor, and melanoma were also considered because of the presence o... | ['Animals', 'Dog Diseases', 'Dogs', 'Female', 'Hemosiderin', 'Plasmacytoma', 'Rectal Neoplasms'] | 19,605,892 | [['B01.050'], ['C22.268'], ['B01.050.150.900.649.313.750.250.216.200'], ['D12.776.556.526'], ['C04.557.595.600', 'C20.683.515.880'], ['C04.588.274.476.411.307.790', 'C06.301.371.411.307.790', 'C06.405.249.411.307.790', 'C06.405.469.491.307.790', 'C06.405.469.860.180.500']] | ['Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effect of ammonia production on intracellular pH: Consequent effect on adenovirus vector production. | Recombinant adenoviral vectors (AdV) have proven to be highly efficient for the delivery and expression of foreign genes in a broad spectrum of cell types and species both for vaccination and gene therapy in a number of specific applications. In this study, the effect of ammonia production on intracellular pH (pH(i)) a... | ['Adenoviridae', 'Ammonia', 'Biotechnology', 'Cell Count', 'Cell Culture Techniques', 'Cell Line', 'Endodeoxyribonucleases', 'Flow Cytometry', 'Genetic Vectors', 'Humans', 'Hydrogen-Ion Concentration', 'Virus Cultivation'] | 17,313,985 | [['B04.280.030'], ['D01.362.075', 'D01.625.050'], ['H01.158.550', 'J01.897.120'], ['E01.370.225.500.195', 'E05.200.500.195', 'E05.242.195', 'G04.140'], ['E01.370.225.500.223', 'E05.200.500.265', 'E05.242.223', 'E05.481.500.249'], ['A11.251.210'], ['D08.811.277.352.335.350', 'D08.811.277.352.355.325'], ['E01.370.225.500... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Assessment of genetic diversity and relationships among Salvia | To detect the genetic variation and relationships among different Salvia ecotypes/species, the gene targeted CAAT box derived polymorphism (CBDP) markers were employed in terms of their efficiency. In this study, 25 CBDP primers amplified a total of 323 different polymorphic fragments that discriminate all 26 Salvia ec... | ['Alleles', 'Cluster Analysis', 'DNA, Plant', 'Gene Flow', 'Genetic Markers', 'Genetics, Population', 'Nucleotide Motifs', 'Phylogeny', 'Polymorphism, Genetic', 'Salvia'] | 31,544,779 | [['G05.360.340.024.340.030'], ['E05.318.740.250', 'N05.715.360.750.200', 'N06.850.520.830.250'], ['D13.444.308.435'], ['G05.330.159'], ['D23.101.387', 'G05.695.450'], ['H01.158.273.343.335'], ['G02.111.570.080.611', 'G02.111.570.820.486.662', 'G05.360.080.611', 'G05.360.580.662'], ['G05.697', 'G16.075.605', 'L01.100.69... | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Information Science [L]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
[Human biological age]. | By biological age is understood that state of the organism, with the inclusion of both physical and psychic parameters, which has been reached at a certain point of the chronological age. Experiments are reported which have been conducted in an attempt to measure the biological age of human beings by the aid of batteri... | ['Aged', 'Aging', 'Diabetes Mellitus', 'Female', 'Humans', 'Hypertension', 'Longitudinal Studies', 'Male', 'Obesity', 'Risk'] | 7,347,935 | [['M01.060.116.100'], ['G07.345.124'], ['C18.452.394.750', 'C19.246'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['E05.318.372.500.750.500', 'N05.715.360.330.500.750.500', 'N06.850.520.450.500.750.500'], ['C18.654.726.500', 'C23.888.144.699.500', 'E01.370.600.115.100.160.120.699.500', 'G07.100.1... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Prediction of long-term mortality in patients with rheumatoid arthritis according to simple questionnaire and joint count measures. | OBJECTIVE: To describe mortality over 15 years in a cohort of patients with rheumatoid arthritis, according to a simple questionnaire and joint count.DESIGN: A cohort study with 15 years of follow-up.SETTING: University hospital outpatient clinic.PATIENTS: A cohort of 75 patients with rheumatoid arthritis.MEASUREMENTS:... | ['Activities of Daily Living', 'Actuarial Analysis', 'Arthritis, Rheumatoid', 'Female', 'Follow-Up Studies', 'Humans', 'Joints', 'Male', 'Middle Aged', 'Physical Examination', 'Predictive Value of Tests', 'Proportional Hazards Models', 'Severity of Illness Index', 'Surveys and Questionnaires', 'Survival Analysis'] | 8,250,453 | [['E02.760.169.063.500.067', 'E02.831.067', 'I03.050', 'N02.421.784.110'], ['E05.318.740.100', 'N05.715.360.750.100', 'N06.850.520.830.100'], ['C05.550.114.154', 'C05.799.114', 'C17.300.775.099', 'C20.111.199'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Named Groups [M]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
[Artificial Intelligence in Smart Health: Investigation of Theory and Practice]. | The World Health Organization defines Smart Healthcare as "Information and Communication Technology applications in the medical and health fields, including medical care, disease management, public health monitoring, education, and research." In addition, many scholars believe that "Smart Healthcare" refers also to the... | ['Algorithms', 'Artificial Intelligence', 'Delivery of Health Care', 'Humans', 'Information Technology', 'Medical Informatics'] | 30,924,509 | [['G17.035', 'L01.224.050'], ['G17.035.250', 'L01.224.050.375'], ['N04.590.374', 'N05.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.479'], ['L01.313.500']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Complications of repeated operations to control esophageal reflux (esophagogastrocutaneous and esophagogastropericardial fistulas). | Iatrogenic injury to the distal esophagus and gastric cardia with subsequent fistula formation may occur at times following repeated direct operative attempts to control reflux esophagitis. At re-operation when this problem occurs, the indirect operative procedure of Roux-en-Y diversion is a safe, effective and prefera... | ['Aged', 'Colonic Diseases', 'Esophageal Fistula', 'Female', 'Fistula', 'Gastric Fistula', 'Gastroesophageal Reflux', 'Hernia, Hiatal', 'Humans', 'Intestinal Fistula', 'Male', 'Middle Aged', 'Pericardium', 'Postoperative Complications', 'Radiography', 'Skin Diseases'] | 851,291 | [['M01.060.116.100'], ['C06.405.469.158'], ['C06.267.250', 'C06.405.117.367', 'C23.300.575.185.250'], ['C23.300.575'], ['C06.267.375', 'C23.300.575.185.375'], ['C06.405.117.119.500.484'], ['C23.300.707.960.500.467'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C06.267.550', 'C06.405.469.471', 'C23.300.575.185.55... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Mechanism underlying 2-methoxyestradiol inducing apoptosis of K562 cells]. | The aim of this study was to investigate apoptotic effect of 2-methoxyestradiol (2-ME2) on K562 cells and its mechanism. K562 cells were treated with different concentrations of 2-ME2. MTT assay was used to examine the effect inducing growth inhibition. DNA fragmentation assay and Annexin V-FITC/PI staining were used t... | ['2-Methoxyestradiol', 'Apoptosis', 'Cell Proliferation', 'Cytochromes c', 'Down-Regulation', 'Estradiol', 'Humans', 'K562 Cells', 'Proto-Oncogene Proteins c-akt', 'Proto-Oncogene Proteins c-bcl-2', 'RNA, Messenger'] | 19,379,563 | [['D04.210.500.365.415.248.830', 'D06.472.334.851.437.500.750'], ['G04.146.954.035'], ['G04.161.750', 'G07.345.249.410.750'], ['D08.244.286.100', 'D12.776.422.220.286.100'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['D04.210.500.365.415.248', 'D06.472.334.851.437.500'], ['B01.050.150.900.649.313.988.400.112.4... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
CD56 and PGP expression in acute myeloid leukemia: impact on clinical outcome. | BACKGROUND AND OBJECTIVES: Overexpression of P-glycoprotein (PGP), a multidrug-related (MDR) protein, is one of the most important factors responsible for reduced drug sensitivity in acute myeloid leukemia (AML). Recently, we demonstrated that the presence of CD56 antigen, an isoform of the neural adhesion molecule, in... | ['ATP Binding Cassette Transporter, Subfamily B, Member 1', 'Acute Disease', 'Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'CD56 Antigen', 'Female', 'Humans', 'Immunophenotyping', 'Leukemia, Myeloid', 'Male', 'Middle Aged', 'Prognosis', 'Survival Analysis', 'Treatment Outcome'] | 12,414,342 | [['D12.776.157.530.100.075.063', 'D12.776.157.530.450.074.500.500.250.125', 'D12.776.395.550.020.400.153', 'D12.776.543.550.192.400.153', 'D12.776.543.585.100.200.125', 'D12.776.543.585.450.074.500.500.250.125'], ['C23.550.291.125'], ['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D12.... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Characterization of B-cell lines from SLE patients and their relatives. | Epstein-Barr-virus (EBV)-transformed lymphoblastoid B-cell lines were generated from peripheral blood lymphocytes of 55 patients with systemic lupus erythematosus (SLE) and 44 healthy relatives. All donors have previously been extensively characterized with regard to clinical, serologic, and genetic parameters. Here, p... | ['Antigens, Surface', 'B-Lymphocytes', 'Cell Division', 'Cell Line, Transformed', 'Fluorescent Antibody Technique, Indirect', 'Herpesvirus 4, Human', 'Humans', 'Immunoglobulins', 'Lupus Erythematosus, Systemic', 'Nuclear Family'] | 8,588,125 | [['D23.050.301'], ['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.251.210.172'], ['E01.370.225.500.607.512.240.310', 'E01.370.225.750.551.512.240.310', 'E05.200.500.60... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
Anxiety enhances threat processing without competition among multiple inputs: a diffusion model analysis. | Enhanced processing of threatening information is a well established phenomenon among high-anxious individuals. This effect is most reliably shown in situations where 2 or more items compete for processing resources, suggesting that input competition is a critical component of the effect. However, it could be that ther... | ['Anxiety', 'Electronic Data Processing', 'Female', 'Humans', 'Linguistics', 'Male', 'Models, Psychological'] | 21,038,949 | [['F01.470.132'], ['L01.224.085'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.559.598'], ['E05.599.695']] | ['Psychiatry and Psychology [F]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Cefotaxime-resistant Salmonella enterica in travelers returning from Thailand to Finland. | During 1993-2011, cefotaxime resistance among Salmonella enterica isolates from patients in Finland increased substantially. Most of these infections originated in Thailand; many were qnr positive and belonged to S. enterica serovar Typhimurium and S. enterica monophasic serovar 4,[5],12:i:-. Although cefotaxime-resist... | ['Anti-Bacterial Agents', 'Cefotaxime', 'Drug Resistance, Bacterial', 'Finland', 'Humans', 'Salmonella Infections', 'Salmonella enterica', 'Thailand', 'Travel'] | 24,960,266 | [['D27.505.954.122.085'], ['D02.065.589.099.249.190.190', 'D02.886.665.074.190.190', 'D03.633.100.300.249.190.190'], ['G06.099.225', 'G06.225.347', 'G07.690.773.984.269.347'], ['Z01.542.816.186'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C01.150.252.400.310.821'], ['B03.440.450.425.800.200', 'B03.660.250.150.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Organisms [B]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 |
Efficacy of low doses of fenbendazole and its administration via drinking water in the prophylaxis of nematodiasis in grazing calves. | Under experimental conditions, fenbendazole given at doses of 0.4 and 1.0 mg/kg body weight suppressed calves' faecal output of Ostertagia and Cooperia species eggs and Dictyocaulus viviparus larvae. Both dose levels were given in the form of small daily drenches and the higher level showed greater efficacy. In a grazi... | ['Administration, Oral', 'Animals', 'Benzimidazoles', 'Cattle', 'Cattle Diseases', 'Dictyocaulus Infections', 'Drinking', 'Feces', 'Fenbendazole', 'Male', 'Nematode Infections', 'Ostertagiasis', 'Parasite Egg Count', 'Seasons'] | 3,157,260 | [['E02.319.267.100'], ['B01.050'], ['D03.633.100.103'], ['B01.050.150.900.649.313.500.380.271'], ['C22.196'], ['C01.610.335.349.315', 'C01.610.335.508.700.775.825.315', 'C01.610.701.377.315', 'C22.674.377.315'], ['G07.203.650.283.249', 'G10.261.330.249'], ['A12.459'], ['D02.241.081.251.320', 'D03.633.100.103.450'], ['C... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Normal values for microperimetry with the MAIA microperimeter: sensitivity and fixation analysis in healthy adults and children. | PURPOSE: To establish normative values of retinal sensitivity and parameters describing the fixation pattern using macular analyzer integrity assessment (MAIA) microperimetry (Centervue, Padova, Italy) in adults and children.METHODS: A sample of 237 eyes of 237 healthy subjects aged between 10 and 70 years (mean age 30... | ['Adolescent', 'Adult', 'Aged', 'Child', 'Female', 'Fixation, Ocular', 'Humans', 'Macula Lutea', 'Male', 'Middle Aged', 'Reference Values', 'Reproducibility of Results', 'Visual Acuity', 'Visual Field Tests', 'Visual Fields', 'Young Adult'] | 28,127,734 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.406'], ['G14.350.253'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A09.371.729.522'], ['M01.060.116.630'], ['E05.978.810'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['E01.370.380.850.950', 'F02.463.593.932... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Manual action verbs modulate the grip force of each hand in unimanual or symmetrical bimanual tasks. | Manual action verbs modulate the right-hand grip force in right-handed subjects. However, to our knowledge, no studies demonstrate the ability to accomplish this modulation during bimanual tasks nor describe their effect on left-hand behavior in unimanual and bimanual tasks. Using load cells and word playlists, we eval... | ['Adult', 'Female', 'Functional Laterality', 'Hand Strength', 'Humans', 'Male', 'Middle Aged', 'Young Adult'] | 29,401,468 | [['M01.060.116'], ['F02.830.297.425', 'G11.561.225.425'], ['E01.370.600.425.500', 'G11.427.560.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['M01.060.116.815']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Effect of direct, reflex and exercise-provoked increases in sympathetic tone on idiopathic ventricular tachycardia. | Exercise treadmill testing and direct enhancement of sympathetic influence with agents such as isoproterenol are often used to reproduce ventricular tachycardia (VT). The cardiac effects of, and arrhythmia responses to, graded exercise, isoproterenol infusion and lower body negative pressure (the latter 2 with and with... | ['Adult', 'Aged', 'Blood Pressure', 'Cardiac Pacing, Artificial', 'Electrocardiography', 'Female', 'Heart Rate', 'Heart Ventricles', 'Humans', 'Isoproterenol', 'Lower Body Negative Pressure', 'Male', 'Middle Aged', 'Physical Exertion', 'Reflex', 'Sympathetic Nervous System', 'Tachycardia'] | 1,590,233 | [['M01.060.116'], ['M01.060.116.100'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E02.331.200'], ['E01.370.370.380.240', 'E01.370.405.240'], ['E01.370.600.875.500', 'G09.330.380.500'], ['A07.541.560'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.033.100.291.439', 'D02.092.063.291.439', 'D02.092.311.649', ... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Transcriptional activity at supraoptimal temperature of growth in the antarctic psychrotrophic bacterium Pseudomonas syringae. | Transcriptional activity was monitored in cells of the Antarctic psychrotrophic bacterium Pseudomonas syringae (Lz4W), which does not grow above 30 degrees C. It was observed that the bacterium was capable of synthesising RNA at a temperature range of 0-37 degrees C, both in vitro and in vivo. The net incorporation of ... | ['Animals', 'Bacterial Proteins', 'Cattle', 'Hot Temperature', 'Pseudomonas', 'RNA, Bacterial', 'RNA, Ribosomal', 'Ribonucleases', 'Transcription, Genetic'] | 9,922,464 | [['B01.050'], ['D12.776.097'], ['B01.050.150.900.649.313.500.380.271'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.775.710.380', 'N06.230.300.100.725.232', 'N06.230.300.100.725.710.380'], ['B03.440.400.425.625.625', 'B03.660.250.580.590'], ['D13.444.735.473'], ['D13.444.735.686'], ['D08.811.277.352... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Neonatal platelet activation in preeclampsia. | Preeclampsia is associated with an increased platelet activation; however, there are few studies concerning platelet activation of the newborn. The aim of our study was to compare platelet activation in newborns of preeclamptic mothers to newborns of healthy mothers by using whole blood flow cytometry. Blood samples we... | ['Adenosine Diphosphate', 'Antigens, CD', 'Biomarkers', 'Female', 'Fibrinogen', 'Flow Cytometry', 'HELLP Syndrome', 'Humans', 'Infant, Newborn', 'Male', 'Platelet Activation', 'Pre-Eclampsia', 'Pregnancy'] | 11,190,901 | [['D03.633.100.759.646.138.124', 'D13.695.667.138.124', 'D13.695.827.068.124'], ['D23.050.301.264.035', 'D23.101.100.110'], ['D23.101'], ['D12.776.124.050.250', 'D12.776.124.125.500', 'D12.776.811.300', 'D23.119.490'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.36... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Evaluation of the PG-Numeric assay for semi-automated analysis for phosphatidylglycerol in amniotic fluid. | We evaluated the performance of the PG-Numeric (PGN; Isolab, Inc.) enzymatic assay for phosphatidylglycerol (PG) adapted for semi-automated analysis on the Cobas-Bio (Roche) centrifugal analyzer. We evaluated precision, linearity, and potential interference from endogenous glycerol. In addition, we compared the results... | ['Amniotic Fluid', 'Evaluation Studies as Topic', 'Female', 'Fetus', 'Gestational Age', 'Humans', 'Infant, Newborn', 'Phosphatidylglycerols', 'Pregnancy', 'Prenatal Diagnosis', 'Respiratory Distress Syndrome, Newborn'] | 2,242,581 | [['A12.098', 'A16.378.149'], ['E05.337', 'N05.715.360.335'], ['A16.378'], ['G07.345.500.325.235.968', 'G08.686.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['D10.570.755.375.760.400.885'], ['G08.686.784.769'], ['E01.370.378.630'], ['C08.381.840.500', 'C08.618.840.500', 'C16.614.521.563']... | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Differences in mitogenic responses of murine T cells to two distinct phytohemagglutinin (PHA) subcomponents. | Two distinct mitogenic subcomponents of phytohemagglutinin (PHA)--leucoagglutinin (LA) and "purified" PHA--apparently stimulated different subpopulations of murine T cells. In the DBA/2J strain, the mitogenic responses of splenic lymphocytes to LA reached maximal levels after 24 to 36 hr exposure and almost completely ... | ['Aging', 'Animals', 'Dose-Response Relationship, Immunologic', 'Female', 'Incubators', 'Lymphocyte Activation', 'Mice', 'Mice, Inbred C57BL', 'Mice, Inbred DBA', 'Mitogens', 'Phytohemagglutinins', 'T-Lymphocytes', 'Time Factors'] | 6,974,129 | [['G07.345.124'], ['B01.050'], ['G12.300'], ['E07.461'], ['E01.370.225.812.482', 'E05.200.812.482', 'E05.478.594.530', 'G12.450.050.400.545', 'G12.565'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420'], ['B01.050.050.199.520.520.500', 'B01.... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Differences in chemical composition and internal structure influence systemic host response to implants of biomaterials. | In reconstructive surgery, implantable devices are used to supply a missing function. In tissue engineering, biomaterials serve to guide and eventually deliver cells and/or molecules where a tissue regenerative response is needed. The host organism always reacts to implants of any biomaterial, in some instances even tr... | ['Animals', 'Biocompatible Materials', 'Biomarkers', 'Collagen Type I', 'Cytokines', 'Durapatite', 'Foreign-Body Reaction', 'Immunity, Humoral', 'Inflammation Mediators', 'Mice', 'Mice, Inbred BALB C', 'Polyesters', 'Prosthesis Design', 'Time Factors', 'Tissue Scaffolds'] | 21,534,242 | [['B01.050'], ['D25.130', 'D27.720.102.130', 'J01.637.051.130'], ['D23.101'], ['D05.750.078.280.300.100', 'D12.776.860.300.250.300.100'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['D01.029.260.700.675.374.075.025.300.150', 'D01.146.360.050.300.200', 'D01.578.122.477.300', 'D01.695.625.675.650.075.025.300.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
[Comparative study of group A streptococcal antigens. II. Comparative characteristics of several physico-chemical and immunochemical properties of partially purified M-protein and cytoplasmic protective antigen]. | The authors carried out a comparative physico-chemical and immunochemical study of antigen obtained from the fraction of streptococcus cytoplasm by precipitation with ammonium sulfate, and partially purified M-protein. They proved to be heterogeneous by molecular-weight characteristics when tested by the methods of sed... | ['Antigens, Bacterial', 'Cell Wall', 'Electrophoresis, Disc', 'Immunoelectrophoresis', 'Molecular Weight', 'Precipitin Tests', 'Spectrophotometry', 'Streptococcus pyogenes'] | 785,889 | [['D23.050.161'], ['A11.284.183'], ['E05.196.401.402.236', 'E05.301.300.319.403'], ['E01.370.225.812.735.645.350.350', 'E05.196.401.568', 'E05.200.812.735.645.350.350', 'E05.301.300.568', 'E05.478.594.760.645.350.350', 'E05.478.605.492.350.350'], ['G02.494'], ['E01.370.225.812.735.645', 'E05.196.150.639.500', 'E05.200.... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bilateral video-assisted thoracoscopic thymectomy has a surgical extent similar to that of transsternal extended thymectomy with more favorable early surgical outcomes for myasthenia gravis patients. | BACKGROUND: This study aimed to introduce the authors' surgical technique of bilateral video-assisted thoracoscopic thymectomy (BVT) and to compare their early surgical results between BVT and transsternal extended thymectomy (T3-b thymectomy) for patients with myasthenia gravis (MG).METHODS: The records of 114 patient... | ['Adult', 'Atrophy', 'Chest Tubes', 'Esthetics', 'Female', 'Humans', 'Hyperplasia', 'Length of Stay', 'Male', 'Middle Aged', 'Myasthenia Gravis', 'Narcotics', 'Pain, Postoperative', 'Postoperative Complications', 'Retrospective Studies', 'Thoracic Surgery, Video-Assisted', 'Thymectomy', 'Thymoma', 'Thymus Gland', 'Thym... | 20,721,579 | [['M01.060.116'], ['C23.300.070'], ['E07.858.150'], ['F02.463.785.477', 'K01.752.210'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.444'], ['E02.760.400.480', 'N02.421.585.400.480'], ['M01.060.116.630'], ['C04.588.614.550.500', 'C04.730.856.490', 'C10.114.656', 'C10.574.781.588', 'C10.668.758.725', 'C20.... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Humanities [K]', 'Organisms [B]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Study of the properties of surgical knots of various types]. | In a work, the results of studying the properties of 17 types of the surgical knots of polyamide threads (braided, lisle, monothreads) are presented. The methods for investigation have been developed, criteria for assessment of knot properties chosen. It is shown that irrespective of structure of the polyamide threads,... | ['Humans', 'Nylons', 'Surgical Wound Dehiscence', 'Suture Techniques', 'Sutures', 'Tensile Strength', 'USSR'] | 1,564,853 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['D05.750.716.392', 'D25.720.716.392', 'J01.637.051.720.716.392', 'J01.637.548'], ['C23.550.767.887'], ['E04.987.775'], ['E07.858.690.820'], ['G01.374.850'], ['Z01.542.931', 'Z01.586.950']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 |
Frequency-dependent selection on female morphs driven by premating interactions with males. | Species showing color polymorphisms-the presence of two or more genetically determined color morphs within a single population-are excellent systems for studying the selective forces driving the maintenance of genetic diversity. Despite a shortage of empirical evidence, it is often suggested that negative frequency-dep... | ['Animals', 'Female', 'Genetic Variation', 'Male', 'Mating Preference, Animal', 'Odonata', 'Polymorphism, Genetic', 'Selection, Genetic'] | 26,098,345 | [['B01.050'], ['G05.365'], ['F01.145.113.252.748.300'], ['B01.050.500.131.617.720.750.750'], ['G05.365.795'], ['G05.783']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vindesine and mitomycin C in chemotherapy: refractory advanced breast cancer. | Thirty-five unselected postmenopausal women with metastatic breast carcinoma, refractory to hormonal manipulation and/or chemotherapy, were treated with vindesine (3 mg/m2 day 1, then weekly for 6 weeks, then every other week) and mitomycin (12 mg/m2 day 1, then every 6 weeks). Thirty-one patients were evaluable for re... | ['Adult', 'Aged', 'Antineoplastic Combined Chemotherapy Protocols', 'Breast Neoplasms', 'Female', 'Humans', 'Leukopenia', 'Menopause', 'Middle Aged', 'Mitomycin', 'Mitomycins', 'Nausea', 'Neoplasm Metastasis', 'Neoplasm Staging', 'Peripheral Nervous System Diseases', 'Vindesine'] | 3,002,594 | [['M01.060.116'], ['M01.060.116.100'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['C04.588.180', 'C17.800.090.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C15.378.553.546'], ['G08.686.157.500', 'G08.686.841.249.500'], ['M01.060.116.630'], ['D02.806.400.249.350', 'D03.383.097.500.350', 'D03... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Prevention of chloridazon and metribuzin pollution using lignin-based formulations. | The herbicides chloridazon and metribuzin, identified as groundwater pollutants, were incorporated in lignin-based granules with different sizes to obtain controlled release formulations (CRFs) and reduce water pollution risk. Kinetics release tests in water and soil showed that the release rate of both from CRFs dimin... | ['Chemistry, Agricultural', 'Environmental Pollution', 'Herbicides', 'Kinetics', 'Lignin', 'Pyridazines', 'Soil Pollutants', 'Triazines'] | 20,133,032 | [['H01.181.216'], ['N06.850.460'], ['D27.720.031.700.366', 'D27.888.723.366'], ['G01.374.661', 'G02.111.490'], ['D05.750.078.562.180.515', 'D05.750.078.687', 'D20.538', 'D25.720.099.687', 'J01.637.051.720.099.687'], ['D03.383.710'], ['D27.888.284.756'], ['D03.383.931']] | ['Disciplines and Occupations [H]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 |
Voltage-assisted photoaligning effect of an azo dye doped in a liquid crystal with negative dielectric anisotropy. | We demonstrate a method of controlling the pretilt angle by field-assisted photoalignment in a vertically-aligned liquid crystal doped with a dichroic azo dye. By dynamically measuring both the pretilt angle and anisotropy in absorbance, we present detailed alignment variations in both the polar and azimuthal direction... | ['Anisotropy', 'Azo Compounds', 'Coloring Agents', 'Electric Conductivity', 'Electromagnetic Fields', 'Equipment Design', 'Equipment Failure Analysis', 'Liquid Crystals', 'Refractometry'] | 20,940,882 | [['G01.590.040', 'G02.050'], ['D02.172'], ['D27.720.233'], ['G01.358.500.249.277'], ['G01.358.500.260', 'G01.358.750.500'], ['E05.320'], ['E05.325.192'], ['J01.637.506'], ['E05.196.808', 'H01.671.617.755']] | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Determination of nitrobenzene in water and ice samples collected from the Songhua River after an explosion of a petrochemical plant and investigation on enclosing behavior of nitrobenzene into ice. | In this study, nitrobenzene in water and ice samples collected from the Songhua River after the explosion of a petrochemical plant was determined by GC/MS. The results showed that nitrobenzene was detected in most of the water and ice samples taken from the Songhua River. However, the concentration of nitrobenzene in a... | ['China', 'Explosions', 'Ice', 'Nitrobenzenes', 'Petroleum', 'Rivers', 'Water'] | 20,410,580 | [['Z01.252.474.164'], ['N06.230.208'], ['D01.045.250.875.400', 'D01.248.497.158.459.650.400', 'D01.650.550.925.400', 'G16.500.275.410', 'G16.500.750.775.342', 'N06.230.291'], ['D02.455.426.559.389.565', 'D02.640.529'], ['D20.345.630', 'N06.230.132.258.630'], ['G01.311.750', 'G16.500.275.280.650', 'N06.230.232.650'], ['... | ['Geographicals [Z]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
A Semliki forest virus vector engineered to express IFNá induces efficient elimination of established tumors. | Semliki Forest virus (SFV) represents a promising gene therapy vector for tumor treatment, because it produces high levels of recombinant therapeutic proteins while inducing apoptosis in infected cells. In this study, we constructed a SFV vector expressing murine interferon alpha (IFNá). IFNá displays antitumor activit... | ['Animals', 'Cell Line', 'Cricetinae', 'Disease Models, Animal', 'Female', 'Gene Expression', 'Genetic Therapy', 'Genetic Vectors', 'Immunity, Cellular', 'Injections', 'Interferon-alpha', 'Mice', 'Mice, Inbred C57BL', 'Neoplasms', 'Semliki forest virus'] | 21,734,727 | [['B01.050'], ['A11.251.210'], ['B01.050.150.900.649.313.992.635.075.250'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['G05.297'], ['E02.095.301', 'E05.393.420.301'], ['G05.360.337'], ['G12.450.050.400'], ['E02.319.267.530'], ['D12.644.276.374.440.890.250', 'D12.776.467.374.440.890.250', 'D23.529.374.440.890.250']... | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Uncoupling protein 3 adjusts mitochondrial Ca(2+) uptake to high and low Ca(2+) signals. | Uncoupling proteins 2 and 3 (UCP2/3) are essential for mitochondrial Ca(2+) uptake but both proteins exhibit distinct activities in regard to the source and mode of Ca(2+) mobilization. In the present work, structural determinants of their contribution to mitochondrial Ca(2+) uptake were explored. Previous findings ind... | ['Amino Acid Sequence', 'Calcium', 'Calcium Signaling', 'Cell Line', 'Humans', 'Ion Channels', 'Membrane Transport Proteins', 'Mitochondria', 'Mitochondrial Proteins', 'Mutagenesis, Site-Directed', 'Protein Conformation', 'Uncoupling Protein 2', 'Uncoupling Protein 3'] | 21,047,682 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['G02.111.820.800.100', 'G03.143.500.100', 'G04.835.800.100'], ['A11.251.210'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.157.530.400', 'D12.776.543.550.450', 'D12.776.543.585.400'], ['D12.776.157.530', ... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Androgen and oestrogen modulation by D-aspartate in rat epididymis. | Testosterone (T) synthesised in Leydig cells enters the epididymis and may there be converted into dihydrotestosterone (DHT) by 5á-reductase (5á-red) or into 17â-oestradiol (E2) by P450 aromatase (P450-aro). D-aspartate (D-Asp) is known to induce T synthesis in the testis. In this study, we investigated the effects of ... | ['3-Oxo-5-alpha-Steroid 4-Dehydrogenase', 'Animals', 'Aromatase', 'D-Aspartic Acid', 'Dihydrotestosterone', 'Epididymis', 'Estradiol', 'Estrogens', 'Male', 'Rats', 'Receptors, Androgen', 'Testosterone'] | 26,044,185 | [['D08.811.682.660.465'], ['B01.050'], ['D08.244.453.489.500', 'D08.244.453.915.099', 'D08.811.682.690.708.170.447.500', 'D08.811.682.690.708.170.915.099', 'D12.776.422.220.453.489.500', 'D12.776.422.220.453.915.099'], ['D12.125.067.500.150', 'D12.125.119.170.150'], ['D04.210.500.054.040.248', 'D06.472.334.851.968.964'... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Diphtheria-tetanus skin testing. Its clinical value for delayed hypersensitivity. | Skin testing as an in vivo means of evaluating cell-mediated immune function is extremely valuable. However, problems lie in selecting the appropriate antigens and interpreting the results. The suggestion that diphtheria-tetanus would provide a good antigen in infants and children was evaluated by comparing skin test o... | ['Adolescent', 'Adult', 'Child', 'Child, Preschool', 'Diphtheria Toxoid', 'Evaluation Studies as Topic', 'Humans', 'Hypersensitivity, Delayed', 'Immunity, Cellular', 'Immunologic Deficiency Syndromes', 'Infant', 'Skin', 'Skin Tests', 'Tetanus Toxoid'] | 7,377,155 | [['M01.060.057'], ['M01.060.116'], ['M01.060.406'], ['M01.060.406.448'], ['D20.215.894.691.263'], ['E05.337', 'N05.715.360.335'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C20.543.418'], ['G12.450.050.400'], ['C20.673'], ['M01.060.703'], ['A17.815'], ['E01.370.225.812.871', 'E05.200.812.871', 'E05.478.594.890'... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Isolation and in vitro propagation of human choroidal fibroblasts. Morphology and characterization of the cultures. | Subretinal ingrowth of choroidal fibroblasts is of importance in several clinical settings such as age-related macular degeneration or after traumas such as laser treatment and infection. In the present investigation we describe a method for isolation and propagation of human choroidal fibroblasts in vitro. Outgrowth f... | ['Aged', 'Aged, 80 and over', 'Cell Division', 'Cell Movement', 'Cell Separation', 'Cells, Cultured', 'Choroid', 'Cytoskeletal Proteins', 'Fibroblasts', 'Humans', 'Immunoenzyme Techniques', 'Microscopy, Electron, Scanning', 'Microscopy, Phase-Contrast', 'Middle Aged'] | 8,689,475 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['G04.198', 'G07.568.500.180'], ['E01.370.225.500.363', 'E05.200.500.363', 'E05.242.363'], ['A11.251'], ['A09.371.894.223'], ['D12.776.220'], ['A11.329.228'], ['B01.050.150.900.649.313.988.400.112.40... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
MicroRNA-15b Suppresses Th17 Differentiation and Is Associated with Pathogenesis of Multiple Sclerosis by Targeting O | IL-17-producing Th17 cells have gradually become considered as key factors in the pathogenesis of many autoimmune diseases, including multiple sclerosis (MS). Although the involvement of certain microRNAs in the development of MS has been reported, their role in Th17-driven autoimmunity is still poorly understood. In t... | ['Animals', 'Blotting, Western', 'Cell Differentiation', 'Cell Separation', 'Down-Regulation', 'Encephalomyelitis, Autoimmune, Experimental', 'Flow Cytometry', 'Gene Expression Regulation', 'Gene Knockdown Techniques', 'Humans', 'Immunoprecipitation', 'Mice', 'Mice, Inbred C57BL', 'MicroRNAs', 'Multiple Sclerosis', 'N-... | 28,228,555 | [['B01.050'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['G04.152'], ['E01.370.225.500.363', 'E05.200.500.363', 'E05.242.363'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['C10.114.703.300', 'C10.228.140.695.562.250', 'C10.314.350.250', 'C20.111.258.625... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Improvement of highly thermostable xylanases production by Talaromyces thermophilus for the agro-industrials residue hydrolysis. | A newly isolated thermophilic fungal strain from Tunisian soil samples was identified as Talaromyces thermophilus and was selected for its ability to produce extracellular hemicellulases when grown on various lignocellulosic substrates. Following the optimization of carbon source, nitrogen source, and initial pH of the... | ['Endo-1,4-beta Xylanases', 'Enzyme Stability', 'Fungal Proteins', 'Hot Temperature', 'Hydrolysis', 'Industrial Microbiology', 'Lignin', 'Talaromyces', 'Waste Products'] | 20,349,285 | [['D08.811.277.450.950.249'], ['E05.916.360', 'G02.111.700.500'], ['D12.776.354'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.775.710.380', 'N06.230.300.100.725.232', 'N06.230.300.100.725.710.380'], ['G02.380'], ['H01.158.273.540.460', 'J01.897.120.460'], ['D05.750.078.562.180.515', 'D05.750.078.68... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 |
Bromohypericins are potent photoactive antiviral agents. | Several hypericin derivatives, previously shown to have interesting light-mediated biological activities, were evaluated for antiviral activities against herpes simplex virus and influenza virus. Three brominated hypericins, the dibromo- and tetrabromo-derivatives and the natural compound gymnochrome B were all very ac... | ['Animals', 'Antiviral Agents', 'Cell Line', 'Chlorocebus aethiops', 'Dogs', 'Herpesvirus 1, Human', 'Influenza A virus', 'Perylene', 'Photosensitizing Agents', 'Structure-Activity Relationship', 'Vero Cells'] | 10,568,175 | [['B01.050'], ['D27.505.954.122.388'], ['A11.251.210'], ['B01.050.150.900.649.313.988.400.112.199.120.126.110'], ['B01.050.150.900.649.313.750.250.216.200'], ['B04.280.382.100.750.390'], ['B04.820.480.968.405.400'], ['D02.455.426.559.847.149.700', 'D02.455.426.559.847.680.500', 'D04.615.149.700', 'D04.615.680.500'], ['... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The abundance of cis-acting loci leading to differential allele expression in F1 mice and their relationship to loci harboring genes affecting complex traits. | BACKGROUND: Genome-wide surveys have detected cis-acting quantitative trait loci altering levels of RNA transcripts (RNA-eQTLs) by associating SNV alleles to transcript levels. However, the sensitivity and specificity of detection of cis- expression quantitative trait loci (eQTLs) by genetic approaches, reliant as it i... | ['Alcoholism', 'Alleles', 'Animals', 'Crosses, Genetic', 'Female', 'Gene Expression Regulation', 'Genotype', 'Inheritance Patterns', 'Kidney', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Mice, Inbred DBA', 'Mice, Inbred Strains', 'Neovascularization, Pathologic', 'Organ Specificity', 'Phenotype', 'Prosencephalon', 'Quantita... | 27,515,598 | [['C25.775.100.250', 'F03.900.100.350'], ['G05.360.340.024.340.030'], ['B01.050'], ['E05.393.281'], ['G05.308'], ['G05.380'], ['G05.420'], ['A05.810.453'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420'], ['B01.050.050.199.520.520.500', 'B0... | ['Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Towards the Automatic Classification of Avian Flight Calls for Bioacoustic Monitoring. | Automatic classification of animal vocalizations has great potential to enhance the monitoring of species movements and behaviors. This is particularly true for monitoring nocturnal bird migration, where automated classification of migrants' flight calls could yield new biological insights and conservation applications... | ['Animal Migration', 'Animals', 'Area Under Curve', 'Automation', 'Birds', 'Flight, Animal', 'ROC Curve', 'Seasons', 'Tape Recording', 'Vocalization, Animal'] | 27,880,836 | [['F01.145.113.069.500'], ['B01.050'], ['E05.318.740.200', 'G03.787.101', 'G07.690.725.064', 'N06.850.520.830.200'], ['J01.897.104'], ['B01.050.150.900.248'], ['G11.427.410.568.304', 'G11.427.410.698.416'], ['E05.318.370.800.750', 'E05.318.740.872.750', 'N05.715.360.325.700.680', 'N06.850.520.445.800.750'], ['G01.910.6... | ['Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 |
Conjunctival changes in children with Kawasaki disease: cytopathologic characterization. | OBJECTIVE: To examine the cytopathological changes in the conjunctiva of patients with active Kawasaki disease.STUDY DESIGN: Case-control prospective study. Bilateral conjunctival swabs were obtained from 3 groups of children: patients with acute KD (11), age-matched controls (7), and patients with inactive KD (9). The... | ['Acute Disease', 'Case-Control Studies', 'Child', 'Child, Preschool', 'Conjunctiva', 'Conjunctival Diseases', 'Eosinophils', 'Goblet Cells', 'Humans', 'Lymphocytes', 'Monocytes', 'Mucocutaneous Lymph Node Syndrome', 'Neutrophils', 'Plasma Cells', 'Prospective Studies'] | 17,536,537 | [['C23.550.291.125'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['M01.060.406'], ['M01.060.406.448'], ['A09.371.060.200', 'A09.371.337.168'], ['C11.187'], ['A11.118.637.415.345', 'A11.627.340.345', 'A15.145.229.637.415.345', 'A15.382.490.315.251'], ['A03.556.124.369.320', 'A04.329.5... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Named Groups [M]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Dentine-bonded ceramic crowns: two case reports. | The dentine-bonded ceramic crown is a full coverage restoration luted to the underlying tooth tissue via a dentine bond and resin composite luting system. The main advantage of using this technique is that removal of tooth tissue can be kept to a minimum. Additionally, the final aesthetic results may be excellent. In t... | ['Adolescent', 'Cementation', 'Ceramics', 'Composite Resins', 'Crowns', 'Dental Cements', 'Dental Enamel Hypoplasia', 'Dental Prosthesis Design', 'Dentin-Bonding Agents', 'Esthetics, Dental', 'Female', 'Follow-Up Studies', 'Humans', 'Incisor', 'Tooth Erosion', 'Tooth Fractures', 'Tooth Preparation, Prosthodontic'] | 9,447,769 | [['M01.060.057'], ['E05.170', 'E06.095.170'], ['J01.637.153'], ['D05.750.716.822.308', 'D25.339.816.500', 'D25.720.716.822.308', 'J01.637.051.339.816.500', 'J01.637.051.720.716.822.308'], ['E06.780.346.250', 'E07.695.190.088'], ['D25.339.291', 'J01.637.051.339.291'], ['C07.650.800.255', 'C07.793.700.255', 'C16.131.850.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
[Plasma-digoxin concentration in patients at time of hospital admission (author's transl)]. | Plasma-digoxin and serum creatinine concentrations were determined on admission in 145 unselected patients previously digitalized as outpatients. Adequate digitalization was found in 62.7%, inadequate doses in 15.9% of patients. In the latter group the daily dosage reported by the patients failed to correlate with the ... | ['Ambulatory Care', 'Canrenoic Acid', 'Creatinine', 'Digitalis Glycosides', 'Digoxin', 'Female', 'Hospitalization', 'Humans', 'Male', 'Radioimmunoassay', 'Spironolactone'] | 891,379 | [['E02.760.106', 'N02.421.585.106'], ['D04.210.500.745.432.100'], ['D03.383.129.308.207'], ['D04.210.500.155.580.130.500', 'D09.408.180.261'], ['D04.210.500.155.580.130.500.436', 'D04.210.500.155.580.130.688', 'D09.408.180.261.436'], ['E02.760.400', 'N02.421.585.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], [... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Cloning, expression, and localization of 230-kDa phosphatidylinositol 4-kinase. | A phosphatidylinositol (PI) 4-kinase cDNA was cloned from a rat brain cDNA library. This cDNA encoded a protein of 2041 amino acids with a calculated molecular weight of 231,317. The deduced amino acid sequence shared the identity of 52.3 and 34.4% in the presumed catalytic domain with two yeast PI 4-kinases, STT4 and ... | ['Amino Acid Sequence', 'Animals', 'Base Sequence', 'Cells, Cultured', 'Cloning, Molecular', 'DNA, Complementary', 'GTP-Binding Proteins', 'Molecular Sequence Data', 'Molecular Weight', 'Phosphotransferases (Alcohol Group Acceptor)', 'Rats'] | 8,662,589 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A11.251'], ['E05.393.220'], ['D13.444.308.497.220', 'D13.444.600.223.500', 'D27.720.470.530.600.223.260'], ['D08.811.277.040.330.300', 'D12.776.157.325'], ['L01.453.245.667'], ['G02.494'], ['D08.811.91... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Simultaneous determination of erlotinib and its isomeric major metabolites in human plasma using isocratic liquid chromatography-tandem mass spectrometry and its clinical application. | This study developed a method for the simultaneous determination of erlotinib and its isomeric major metabolites, OSI-413 and OSI-420, in human plasma using an isocratic liquid chromatography-tandem mass spectrometry. Plasma specimens deproteinized with acetonitrile were separated using a 3-µm particle size octadecylsi... | ['Antineoplastic Agents', 'Carcinoma, Non-Small-Cell Lung', 'Chromatography, Liquid', 'Erlotinib Hydrochloride', 'Humans', 'Isomerism', 'Tandem Mass Spectrometry'] | 25,296,722 | [['D27.505.954.248'], ['C04.588.894.797.520.109.220.249', 'C08.381.540.140.500', 'C08.785.520.100.220.500'], ['E05.196.181.400'], ['D03.633.100.786.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.111.570.685', 'G02.607.445'], ['E05.196.566.880']] | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Characterization of the signaling domain of the NO-responsive regulator NorR from Ralstonia eutropha H16 by site-directed mutagenesis. | In Ralstonia eutropha H16, the nitric oxide (NO)-responsive transcriptional activator NorR controls the expression of a dicistronic operon that encodes a membrane-bound NO reductase, NorB, and a protein of unknown function, NorA. The N-terminal domain (NTD) of NorR is responsible for perception of the signal molecule, ... | ['Amino Acid Sequence', 'Amino Acid Substitution', 'Bacterial Proteins', 'Base Sequence', 'Cupriavidus necator', 'DNA Primers', 'Kinetics', 'Molecular Sequence Data', 'Mutagenesis, Site-Directed', 'Oxidoreductases', 'Polymerase Chain Reaction', 'Signal Transduction', 'Spectrophotometry', 'Trans-Activators'] | 17,277,050 | [['G02.111.570.060', 'L01.453.245.667.060'], ['E05.393.420.601.035', 'G05.558.109'], ['D12.776.097'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['B03.440.400.425.251.200.200', 'B03.660.075.090.688.200.200'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['G01.374.661', 'G02.111.490'], ['L... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Glutathione conjugation and induction of a 32,000 dalton stress protein. | Chinese hamster ovary cells were exposed to various concentrations of diethylmaleate in order to produce various levels of intracellular glutathione (GSH) depletion. Exposure to a 20 microM concentration or more of diethylmaleate depleted the intracellular glutathione concentration by 80% or more and resulted in enhanc... | ['Animals', 'Buthionine Sulfoximine', 'Cell Line', 'Cricetinae', 'Dose-Response Relationship, Drug', 'Electrophoresis, Gel, Two-Dimensional', 'Glutathione', 'Heat-Shock Proteins', 'Maleates', 'Methionine Sulfoximine', 'Molecular Weight'] | 2,914,013 | [['B01.050'], ['D02.886.030.676.620.125', 'D12.125.166.676.620.125'], ['A11.251.210'], ['B01.050.150.900.649.313.992.635.075.250'], ['G07.690.773.875', 'G07.690.936.500'], ['E05.196.401.250', 'E05.301.300.230'], ['D12.644.456.448'], ['D12.776.580.216'], ['D02.241.081.337.502'], ['D02.886.030.676.620', 'D12.125.166.676.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Management of liver injuries in Zaria, Nigeria. | The records of 37 patients with liver injuries operated upon at the Ahmadu Bello University Teaching Hospital, Zaria, Nigeria from 1976 to 1987 were reviewed. There were 31 males and 6 females with a mean age of 22 years. Sixty-two per cent were due to blunt injury from road traffic accidents, 14 per cent were due to g... | ['Accidents, Traffic', 'Adolescent', 'Adult', 'Aged', 'Child', 'Child, Preschool', 'Drainage', 'Female', 'Humans', 'Liver', 'Male', 'Middle Aged', 'Multiple Trauma', 'Nigeria', 'Postoperative Complications', 'Retrospective Studies', 'Sutures', 'Wounds and Injuries', 'Wounds, Nonpenetrating', 'Wounds, Penetrating'] | 2,401,550 | [['N06.850.135.392'], ['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.406'], ['M01.060.406.448'], ['E02.309', 'E04.237'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A03.620'], ['M01.060.116.630'], ['C26.640'], ['Z01.058.290.190.565'], ['C23.550.767'], ['E05.318.372.500.500.500', 'E05.318.372.50... | ['Health Care [N]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Geographicals [Z]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Factors affecting the incidence of postoperative wound infection. | A prospective study of postoperative wounds was carried out in West Dorset to determine the incidence of infection, describe the time distribution of presentation before and after discharge from hospital and identify possible contributory factors. There were 702 consecutive patients admitted to the study (600 in-patien... | ['Age Factors', 'Anti-Bacterial Agents', 'Cross Infection', 'Disinfection', 'England', 'Humans', 'Middle Aged', 'Outcome and Process Assessment, Health Care', 'Premedication', 'Preoperative Care', 'Prospective Studies', 'Surgery Department, Hospital', 'Surgical Wound Infection'] | 1,979,572 | [['N05.715.350.075', 'N06.850.490.250'], ['D27.505.954.122.085'], ['C01.248', 'C23.550.291.875.500'], ['N06.850.780.200.450.850.375'], ['Z01.542.363.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['N04.761.559', 'N05.715.360.575'], ['E02.319.703'], ['E02.760.795', 'E04.604.750', 'N02.421.5... | ['Health Care [N]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Geographicals [Z]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Specific activation of CD4- | Cardiomyopathy is the most severe outcome of Chagas disease, causing more than 12 000 deaths/year. Immune cells participate in cardiomyopathy development either by direct tissue destruction, or by driving inflammation. We have shown that CD4- CD8- [double-negative (DN)] T cells are major sources of inflammatory and ant... | ['Adult', 'Aged', 'Antigens, Protozoan', 'CD4 Antigens', 'CD8 Antigens', 'Cardiomyopathies', 'Cell Differentiation', 'Cells, Cultured', 'Chagas Disease', 'Cytokines', 'Disease Progression', 'Female', 'Glycolipids', 'Humans', 'Inflammation', 'Inflammation Mediators', 'Lymphocyte Activation', 'Male', 'Middle Aged', 'Rece... | 28,543,170 | [['M01.060.116'], ['M01.060.116.100'], ['D23.050.293'], ['D12.776.543.750.705.852.420.810.500', 'D12.776.543.750.830.700.025', 'D23.050.301.264.894.100', 'D23.101.100.894.100'], ['D23.050.301.264.894.108', 'D23.101.100.894.108'], ['C14.280.238'], ['G04.152'], ['A11.251'], ['C01.610.752.300.900.200', 'C01.920.625'], ['D... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The BDNF Val66Met Polymorphism Influences Reading Ability and Patterns of Neural Activation in Children. | Understanding how genes impact the brain's functional activation for learning and cognition during development remains limited. We asked whether a common genetic variant in the BDNF gene (the Val66Met polymorphism) modulates neural activation in the young brain during a critical period for the emergence and maturation ... | ['Brain-Derived Neurotrophic Factor', 'Child', 'Cognition', 'Female', 'Frontal Lobe', 'Gene Frequency', 'Genotype', 'Hippocampus', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Memory', 'Neurons', 'Polymorphism, Single Nucleotide', 'Reading'] | 27,551,971 | [['D12.644.276.860.100', 'D12.776.467.860.100', 'D12.776.631.600.100', 'D23.529.850.100'], ['M01.060.406'], ['F02.463.188'], ['A08.186.211.200.885.287.500.270'], ['G05.330'], ['G05.380'], ['A08.186.211.180.405', 'A08.186.211.200.885.287.500.345'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500']... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
[Morphology of the adult human olfactory epithelium]. | The morphological observation of adult human mucous membrane has been investigated with the light microscope and T.E.M. Olfactory mucous membrane is separated into epithelium and lamina propria by basement membrane. The lamina propria contains a lot of Bowman's glands. There are many secretory granules in the cytoplasm... | ['Aged', 'Basement Membrane', 'Epithelium', 'Humans', 'Microscopy, Electron', 'Middle Aged', 'Olfactory Mucosa', 'Olfactory Receptor Neurons'] | 7,742,028 | [['M01.060.116.100'], ['A10.272.220', 'A10.615.179'], ['A10.272'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.515.402', 'E05.595.402'], ['M01.060.116.630'], ['A04.531.520.573', 'A04.760.600.640', 'A09.531.623', 'A10.615.550.760.600.640'], ['A04.531.520.573.580', 'A04.760.600.640.640', 'A08.675.650.9... | ['Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Smooth muscle differentiation in normal human ovaries, ovarian stromal hyperplasia and ovarian granulosa-stromal cells tumors. | An immunohistochemical and ultrastructural investigation on the presence of "smooth muscle differentiation" in stromal ovarian tissue was carried out in 10 adult granulosa cell tumors, six juvenile granulosa cell tumors, six thecoma/fibrothecomas, six cases of stromal hyperplasia, and in 10 normal ovaries. For immunohi... | ['Actins', 'Adult', 'Biomarkers, Tumor', 'Desmin', 'Female', 'Granulosa Cell Tumor', 'Humans', 'Hyperplasia', 'Immunohistochemistry', 'Microscopy, Electron', 'Muscle, Smooth', 'Ovarian Neoplasms', 'Ovary', 'Sex Cord-Gonadal Stromal Tumors'] | 7,731,938 | [['D05.750.078.730.250', 'D12.776.210.500.100', 'D12.776.220.525.255'], ['M01.060.116'], ['D23.101.140'], ['D05.750.078.593.200', 'D12.776.220.475.200'], ['C04.557.475.750.656', 'C04.588.322.455.398', 'C13.351.500.056.630.705.398', 'C13.351.937.418.685.398', 'C19.344.410.398', 'C19.391.630.705.398'], ['B01.050.150.900.... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Pharmacology of topical retinoids. | The goal of research into retinoic acid is to maintain or improve the pharmacologic activities of topically applied retinoic acid while decreasing both local and systemic toxicity and improving chemical stability. Data are presented from a wide range of in vitro and in vivo test systems for retinoic acid, its congeners... | ['Administration, Topical', 'Animals', 'Binding Sites', 'Carrier Proteins', 'Cell Division', 'Cell Line', 'Cells, Cultured', 'Humans', 'Receptors, Retinoic Acid', 'Retinoids', 'Teratoma', 'Tretinoin'] | 3,021,828 | [['E02.319.267.120'], ['B01.050'], ['G02.111.570.120'], ['D12.776.157'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.251.210'], ['A11.251'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.826.701', 'D12.776.930.775'], ['D02.455.326.271.665.202.495', 'D02.455.426.392.368.3... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Single nucleotide polymorphisms in exon 10 of the chinchilla growth hormone receptor (GHR) gene. | The aim of this study was to detect SNPs in exon 10 of the chinchilla growth hormone receptor gene (GHR) by comparative sequencing. Sixty females of the same breed (Standard) were analysed. Four new SNPs were identified, which cause 3 amino acid substitutions in the intracellular domain of the receptor: G/C at position... | ['Animals', 'Base Sequence', 'Chinchilla', 'DNA Primers', 'Exons', 'Female', 'Molecular Sequence Data', 'Polymorphism, Single Nucleotide', 'Receptors, Somatotropin', 'Sequence Analysis, DNA'] | 16,278,515 | [['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['B01.050.150.900.649.313.992.328'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['G05.360.340.024.340.137.232'], ['L01.453.245.667'], ['G05.365.795.598'], ['D12.776.543.750.750.555.770', 'D12.776.543.750.750.660.750'], ['E05.393.7... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Suicidality in adjustment disorder--clinical characteristics of adolescent outpatients. | OBJECTIVE: Although a remarkable proportion of adolescents suffering from adjustment disorder (AD) are suicidal, few studies have documented the characteristics of suicidal AD patients. We examined background, psychopathology and treatment-related factors among suicidal adolescent AD outpatients.METHOD: Data on 302 con... | ['Adjustment Disorders', 'Adolescent', 'Adult', 'Child', 'Diagnostic and Statistical Manual of Mental Disorders', 'Female', 'Humans', 'Male', 'Patient Dropouts', 'Suicide, Attempted'] | 15,959,663 | [['F03.950.500'], ['M01.060.057'], ['M01.060.116'], ['M01.060.406'], ['L01.453.245.945.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.100.150.750.500.610', 'F01.145.488.887.500.610', 'N05.300.150.800.500.610'], ['F01.145.126.980.875.600', 'I01.880.735.856.600']] | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Information Science [L]', 'Organisms [B]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 0 |
Immunohistochemical localization of choline acetyltransferase of a peripheral type in the rat larynx. | As shown in the accompanying paper, choline acetyltransferase, so far the best histochemical marker for identifying cholinergic structures, has at least one alternative splice variant. The variant, termed pChAT because of its preferential expression in peripheral organs, encouraged us to study peripheral, probably chol... | ['Afferent Pathways', 'Animals', 'Capsaicin', 'Choline O-Acetyltransferase', 'Denervation', 'Efferent Pathways', 'Immunoenzyme Techniques', 'Immunohistochemistry', 'Laryngeal Muscles', 'Laryngeal Nerves', 'Larynx', 'Male', 'Medulla Oblongata', 'Nerve Fibers', 'Pain', 'Rats', 'Rats, Wistar', 'Vagotomy', 'Viscera'] | 10,569,237 | [['A08.612.220'], ['B01.050'], ['D02.065.690.500', 'D02.455.326.271.690.222', 'D02.455.426.559.389.657.166.099', 'D03.132.760.200', 'D10.251.355.325.190'], ['D08.811.913.050.134.180'], ['E04.525.210'], ['A08.612.380'], ['E05.478.566.350', 'E05.478.583.400', 'E05.601.470.350'], ['E01.370.225.500.607.512', 'E01.370.225.7... | ['Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Panniculectomy in conjunction with radical cystectomy in the obese patient. | Obesity in the abdominal area causes difficulty not only with the placement of an ileal conduit stoma and conduit length but also with surgical exposure during radical surgery to the pelvis. Such problems may be ameliorated by using a horizontal abdominal dermolipectomy in conjunction with a midline fascial and periton... | ['Abdomen', 'Abdominal Muscles', 'Adipose Tissue', 'Female', 'Humans', 'Ileostomy', 'Methods', 'Obesity', 'Urinary Bladder', 'Urinary Diversion'] | 6,216,617 | [['A01.923.047'], ['A02.633.567.050'], ['A10.165.114'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.210.338.508', 'E04.579.338.508'], ['E05.581'], ['C18.654.726.500', 'C23.888.144.699.500', 'E01.370.600.115.100.160.120.699.500', 'G07.100.100.160.120.699.500'], ['A05.810.890'], ['E04.950.774.852']] | ['Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Distribution of glycoproteins on feline testicular sperm, epididymal sperm and ejaculated sperm. | Glycoproteins (GPs) are known to be involved in the phenomenon of sperm maturation and capacitation. In the present study, we investigated the attachment of GPs on sperm cell membrane during the process of feline sperm maturation from testicular sperm to ejaculated sperm by using 8 FITC-labeled lectins. The results sho... | ['Animals', 'Cats', 'Epididymis', 'Fluorescein-5-isothiocyanate', 'Glycoproteins', 'Lectins', 'Male', 'Microscopy, Fluorescence', 'Spermatozoa', 'Testis'] | 21,282,936 | [['B01.050'], ['B01.050.150.900.649.313.750.377.750.250.125'], ['A05.360.444.371'], ['D02.455.426.779.347.400', 'D02.500.375.250', 'D02.886.250.250', 'D03.633.300.953.275.400', 'D04.711.347.400'], ['D09.400.430', 'D12.776.395'], ['D12.776.503'], ['E01.370.350.515.458', 'E05.595.458'], ['A05.360.490.890', 'A11.497.760']... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Low-dose combination of alendronate and atorvastatin reduces ligature-induced alveolar bone loss in rats. | BACKGROUND AND OBJECTIVE: Atorvastatin (ATV) has bone anabolic properties, and alendronate (ALD) is an important antiresorptive drug. This study aimed to evaluate the effects of the combination of ALD and ATV on ligature-induced alveolar bone loss in rats.MATERIAL AND METHODS: Periodontitis was induced by ligature in 7... | ['Acid Phosphatase', 'Alanine Transaminase', 'Alendronate', 'Alkaline Phosphatase', 'Alveolar Bone Loss', 'Animals', 'Aspartate Aminotransferases', 'Atorvastatin', 'Body Weight', 'Bone Density Conservation Agents', 'Dental Cementum', 'Gingiva', 'Heptanoic Acids', 'Hydroxymethylglutaryl-CoA Reductase Inhibitors', 'Infus... | 23,742,139 | [['D08.811.277.352.650.025'], ['D08.811.913.477.700.100'], ['D02.705.429.500.100'], ['D08.811.277.352.650.035'], ['C05.116.264.150', 'C07.465.714.354.500'], ['B01.050'], ['D08.811.913.477.700.225'], ['D03.383.129.578.075', 'D10.251.450.200'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.10... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A novel class of developmentally regulated noncoding RNAs in Leishmania. | Leishmania is a protozoan parasite that causes serious morbidity and mortality in humans worldwide. The ability of these parasites to survive within the phagolysosomes of mammalian macrophages is dependent on the developmental regulation of a variety of genes. Identifying genomic sequences that are preferentially expre... | ['Animals', 'Base Sequence', 'Conserved Sequence', 'Cricetinae', 'DNA, Protozoan', 'Gene Expression Regulation, Developmental', 'Genes, Protozoan', 'Humans', 'Leishmania infantum', 'Molecular Sequence Data', 'RNA Splicing', 'RNA Stability', 'RNA, Protozoan', 'RNA, Untranslated', 'Ribonucleoproteins', 'Sequence Homology... | 17,071,827 | [['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G02.111.570.580'], ['B01.050.150.900.649.313.992.635.075.250'], ['D13.444.308.442'], ['G05.308.310'], ['G05.360.340.024.340.396', 'G05.360.340.397.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.268.475.868.488.325'], ['L01.453.245... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Active Src expression is induced after rat peripheral nerve injury. | The non-receptor-type Src tyrosine kinases are key components of intracellular signal transduction that are expressed at high levels in the nervous system. To improve understanding of the cascades of molecular events underlying peripheral nerve regeneration, we analyzed active Src expression in the crushed or cut rat s... | ['Animals', 'Axons', 'Axotomy', 'Cell Communication', 'Disease Models, Animal', 'Ectodysplasins', 'GAP-43 Protein', 'Immunohistochemistry', 'Male', 'Membrane Proteins', 'Nerve Crush', 'Nerve Regeneration', 'Neurofilament Proteins', 'Proto-Oncogene Proteins', 'Proto-Oncogene Proteins c-fyn', 'Rats', 'Rats, Sprague-Dawle... | 12,655,602 | [['B01.050'], ['A08.675.542.145', 'A11.284.180.075', 'A11.671.137', 'A11.671.501.145'], ['E04.525.210.158'], ['G04.085'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['D12.644.276.374.750.186', 'D12.776.395.550.275', 'D12.776.467.374.750.186', 'D12.776.543.550.275', 'D23.529.374.750.186'], ['D12.776.395.550.400', 'D... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
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