Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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The influence of VKORC1 and CYP2C9 gene sequence variants on the stability of maintenance phase warfarin treatment. | INTRODUCTION: A substantial part of the inter-individual variation in vitamin K-antagonist dose can be explained by certain sequence variants in the genes CYP2C9 (NG_008385.1:g.8633C>T or *1/*2, NG_008385.1:g.47639A>C or *1/*3) and VKORC1 (NG_011564.1:g.6399C>T). Patients possessing these variant alleles require lower ... | ['Aged', 'Alleles', 'Aryl Hydrocarbon Hydroxylases', 'Blood Coagulation', 'Cytochrome P-450 CYP2C9', 'Female', 'Genetic Variation', 'Genotype', 'Humans', 'International Normalized Ratio', 'Male', 'Middle Aged', 'Mixed Function Oxygenases', 'Prospective Studies', 'Vitamin K Epoxide Reductases', 'Warfarin'] | 23,159,229 | [['M01.060.116.100'], ['G05.360.340.024.340.030'], ['D08.244.453.005', 'D08.811.682.690.708.170.010', 'D12.776.422.220.453.010'], ['G09.188.390.150'], ['D08.244.453.491.500.500', 'D08.811.682.690.708.170.450.500.500', 'D12.776.422.220.453.491.500.500'], ['G05.365'], ['G05.380'], ['B01.050.150.900.649.313.988.400.112.40... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Hsp90 modulates CAG repeat instability in human cells. | The Hsp90 molecular chaperone has been implicated as a contributor to evolution in several organisms by revealing cryptic variation that can yield dramatic phenotypes when the chaperone is diverted from its normal functions by environmental stress. In addition, as a cancer drug target, Hsp90 inhibition has been documen... | ['Cell Line', 'HSP90 Heat-Shock Proteins', 'Humans', 'Immunoblotting', 'Microsatellite Instability', 'RNA, Small Interfering', 'Rad51 Recombinase', 'Trinucleotide Repeats'] | 20,373,063 | [['A11.251.210'], ['D12.776.580.216.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.478.566.320', 'E05.601.470.320'], ['C23.550.362.590', 'G05.365.590.335.590', 'G05.370.590'], ['D13.150.650.700', 'D13.444.735.150.700', 'D13.444.735.790.552.875'], ['D08.811.739.650.500', 'D12.776.260.695', 'D12.776.313.96... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The intermediate state of DMPG is stabilized by enhanced positive spontaneous curvature. | 1,2-Dimyristoyl-sn-glycero-3-phospho-rac-glycerol (DMPG) at low salt concentrations has a complex endotherm with at least four components and extending over the span of 20 degrees. During this ongoing melting, the solution becomes viscous and scatters light poorly. This multipeak endotherm was suggested to result from ... | ['Calorimetry, Differential Scanning', 'Cholesterol', 'Dimethyl Sulfoxide', 'Ethanol', 'Lysophospholipids', 'Models, Theoretical', 'Molecular Structure', 'Phosphatidylglycerols', 'Transition Temperature', 'Urea'] | 20,205,407 | [['E05.196.131.310', 'E05.196.370.310'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['D02.886.640.150'], ['D02.033.375'], ['D10.570.755.375.760.550'], ['E05.599'], ['G02.111.570', 'G02.466'], ['D10.570.755.375.760.400.885'], ['G01.906.595.850'], ['D02.065.950']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Membrane Perturbation of ADP-insensitive Phosphoenzyme of Ca2+ | Ca2+ transport by sarcoplasmic reticulum Ca2+-ATPase involves ATP-dependent phosphorylation of a catalytic aspartic acid residue. The key process, luminal Ca2+ release occurs upon phosphoenzyme isomerization, abbreviated as E1PCa2 (reactive to ADP regenerating ATP and with two occluded Ca2+ at transport sites) ? E2P (i... | ['Animals', 'Calcium Signaling', 'Cell Membrane', 'Cytoplasm', 'Phosphorylation', 'Protein Binding', 'Protein Structure, Tertiary', 'Proteolysis', 'Rabbits', 'Sarcoplasmic Reticulum Calcium-Transporting ATPases'] | 28,117,348 | [['B01.050'], ['G02.111.820.800.100', 'G03.143.500.100', 'G04.835.800.100'], ['A11.284.149'], ['A11.284.430.214'], ['G02.111.665', 'G02.607.780', 'G03.796'], ['G02.111.679', 'G03.808'], ['G02.111.570.820.709.610'], ['G02.111.720', 'G03.812'], ['B01.050.150.900.649.313.968.700'], ['D08.811.277.040.025.314.250.500', 'D12... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A molecular spring for vision. | Light absorption by the visual pigment rhodopsin leads to vision via a complex signal transduction pathway that is initiated by the ultrafast and highly efficient photoreaction of its chromophore, the retinal protonated Schiff base (RPSB). Here, we investigate this reaction in real time by means of unrestrained molecul... | ['Algorithms', 'Models, Molecular', 'Photochemistry', 'Protein Binding', 'Quantum Theory', 'Receptors, G-Protein-Coupled', 'Retinaldehyde', 'Rhodopsin', 'Schiff Bases', 'Thermodynamics'] | 15,563,129 | [['G17.035', 'L01.224.050'], ['E05.599.595'], ['H01.181.529.711'], ['G02.111.679', 'G03.808'], ['H01.671.579.800'], ['D12.776.543.750.695'], ['D02.047.850', 'D02.455.326.271.665.202.495.690', 'D02.455.426.392.368.367.379.249.700.690', 'D02.455.849.131.495.690', 'D02.455.849.291.605', 'D23.767.261.700.690'], ['D12.776.5... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
The effect of "shearing" forces during ultracentrifugation on the membrane-bound polysomes associated with light rough microsomes of MPC-11 cells. | When microsomes, isolated from MPC-11 cells after nitrogen cavitation of cells in buffer containing 100 mM KCl, were separated into light rough (LR) and smooth (S) fractions by discontinuous gradient centrifugation it was observed that [3H]-choline label and A260 nm absorption did not coincide in the LR region of the g... | ['Animals', 'Cell Fractionation', 'Cell Line', 'Centrifugation, Density Gradient', 'False Negative Reactions', 'Intracellular Membranes', 'Mice', 'Microsomes', 'Multiple Myeloma', 'Neoplasms, Experimental', 'Osmolar Concentration', 'Polyribosomes', 'Potassium Chloride'] | 7,412,767 | [['B01.050'], ['E05.242.251'], ['A11.251.210'], ['E05.181.724.336', 'E05.196.941.336'], ['E01.354.340'], ['A11.284.149.450', 'A11.284.835.514'], ['B01.050.150.900.649.313.992.635.505.500'], ['A11.284.835.540'], ['C04.557.595.500', 'C14.907.454.460', 'C15.378.147.780.650', 'C15.378.463.515.460', 'C20.683.515.845', 'C20.... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Subclinical activation of fibrinolysis in atherosclerotic disease detected by B beta 15-42 assay. | Plasma B beta 15-42 and fibrinopeptide A (FPA) concentrations, which are respectively indicators of plasmin and thrombin in vivo activity, were measured in 46 patients with ischemic arterial disease without signs of acute thrombosis. In the group as a whole, an increase in both B beta 15-42 and FPA was found. When the ... | ['Adult', 'Aged', 'Arteriosclerosis', 'Female', 'Fibrin', 'Fibrinogen', 'Fibrinolysin', 'Fibrinolysis', 'Fibrinopeptide A', 'Humans', 'Male', 'Methods', 'Middle Aged', 'Peptide Fragments', 'Thrombin'] | 2,528,202 | [['M01.060.116'], ['M01.060.116.100'], ['C14.907.137.126'], ['D12.776.124.270'], ['D12.776.124.050.250', 'D12.776.124.125.500', 'D12.776.811.300', 'D23.119.490'], ['D08.811.277.656.300.760.330', 'D08.811.277.656.959.350.330'], ['G09.188.390.150.390'], ['D12.644.200', 'D12.776.124.125.515', 'D12.776.124.270.310', 'D12.7... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Comparative studies with scanning electron microscope on the quality of corneal disk incision using various corneal trephine (author's transl)]. | The cut surface of corneal stroma from rabbits was studied with a scanning-electron microscope and compared after using a manual trephine, a motor-driven rotor trephine and a rotor trephine with mechanical guidance. It became evident that the cut surface obtained with the motor-driven trephine is clearly smoother than ... | ['Animals', 'Cornea', 'Methods', 'Microscopy, Electron, Scanning', 'Rabbits'] | 732,207 | [['B01.050'], ['A09.371.060.217'], ['E05.581'], ['E01.370.350.515.402.541', 'E05.595.402.541'], ['B01.050.150.900.649.313.968.700']] | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
They are young, and they are many: dating freshwater lineages in unicellular dinophytes. | Dinophytes are one of few protist groups that have an extensive fossil record and are therefore appropriate for time estimations. However, insufficient sequence data and strong rate heterogeneity have been hindering to put dinophyte evolution into a time frame until now. Marine-to-freshwater transitions within this gro... | ['Climate', 'Dinoflagellida', 'Evolution, Molecular', 'Fossils', 'Fresh Water', 'Phylogeny', 'RNA, Ribosomal', 'Time'] | 31,369,197 | [['G16.500.275.071', 'N06.230.300.100.250'], ['B01.043.214'], ['G05.045.250', 'G16.075.250'], ['I01.076.368.584.311'], ['G16.500.275.280', 'N06.230.232'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['D13.444.735.686'], ['G01.910']] | ['Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Information Science [L]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 |
Functional anatomy of the ligaments of the elbow. | Dissections of 10 fresh cadaver specimens revealed an important insertion of the posterior portion of the lateral collateral ligament to the ulna at the crista supinatoris. The humeral origin of the medial ligament attachments was found to lie posterior to the axis of elbow flexion; in this position a cam effect is cre... | ['Aged', 'Elbow Joint', 'Female', 'Humans', 'Ligaments, Articular', 'Male', 'Middle Aged', 'Movement'] | 4,064,425 | [['M01.060.116.100'], ['A02.835.583.290'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.513.514', 'A02.835.583.512', 'A10.165.669.514'], ['M01.060.116.630'], ['G07.568', 'G11.427.410']] | ['Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Neonatal mouse protection against infection with multiple group B streptococcal (GBS) serotypes by maternal immunization with a tetravalent GBS polysaccharide-tetanus toxoid conjugate vaccine. | Most cases of neonatal sepsis and meningitis caused by group B streptococci (GBS) are attributable to one of four major capsular serotypes: Ia, Ib, II, or III. Because resistance to infection with GBS has been correlated with the presence of serum antibodies to the type-specific capsular polysaccharides in both experim... | ['Animals', 'Animals, Newborn', 'Bacterial Vaccines', 'Carbohydrate Sequence', 'Female', 'Immune Sera', 'Immunity, Maternally-Acquired', 'Mice', 'Molecular Sequence Data', 'Phagocytosis', 'Polysaccharides, Bacterial', 'Rabbits', 'Streptococcal Infections', 'Streptococcus agalactiae', 'Tetanus Toxoid', 'Vaccination', 'V... | 8,039,893 | [['B01.050'], ['B01.050.050.282'], ['D20.215.894.135'], ['G02.111.570.160', 'L01.453.245.667.160'], ['A12.207.152.846.500', 'D12.776.124.486.485.114.573', 'D12.776.124.790.651.114.573', 'D12.776.377.715.548.114.573', 'D20.215.401'], ['G12.450.570'], ['B01.050.150.900.649.313.992.635.505.500'], ['L01.453.245.667'], ['G0... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Detection of ECG waveforms by neural networks. | In this study, ECG waveform detection was performed by using artificial neural networks (ANNs). Initially, the R peak of the QRS complex is detected, and then feature vectors are formed by using the amplitudes of the significant frequency components of the DFT spectrum. Grow and Learn (GAL) and Kohonen networks are com... | ['Bundle-Branch Block', 'Electrocardiography', 'Humans', 'Neural Networks, Computer', 'Ventricular Premature Complexes'] | 9,450,258 | [['C14.280.067.558.323', 'C14.280.123.500.323', 'C23.550.073.425.100'], ['E01.370.370.380.240', 'E01.370.405.240'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G17.485', 'L01.224.050.375.605'], ['C14.280.067.325.500', 'C14.280.123.375.500', 'C23.550.073.325.800']] | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Regulation of biotechnology in the United States and Canada. | The regulation of biotechnology in the United States and Canada is based on principles that reflect respect for the new technology, yet also recognize that most traditional approaches to regulation, employing sound science and common sense, still apply. Four specific principles form the framework on which regulatory sc... | ['Animals', 'Biotechnology', 'Canada', 'Genetic Engineering', 'United States', 'United States Department of Agriculture', 'United States Food and Drug Administration'] | 2,132,699 | [['B01.050'], ['H01.158.550', 'J01.897.120'], ['Z01.107.567.176'], ['E05.393.420'], ['Z01.107.567.875'], ['I01.409.418.750.400', 'N03.540.348.500.500.400'], ['I01.409.418.750.600.650.760', 'N03.540.348.500.500.600.650.760']] | ['Organisms [B]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 1 |
Environmental regulation of mitochondria-rich cells in Chalcalburnus tarichi (Pallas, 1811) during reproductive migration. | Chalcalburnus tarichi is an anadromous cyprinid fish that has adapted to extreme conditions (salinity 22 ‰, pH 9.8 and alkalinity 153 mEq ? l⁻?) in Lake Van in eastern Turkey. Changes in immunoreactivity of Na⁺/K⁺-ATPase in gill tissue and osmolarity and ion levels in plasma were investigated in C. tarichi during repro... | ['Animal Migration', 'Animals', 'Calcium', 'Chlorides', 'Environment', 'Fishes', 'Fresh Water', 'Gills', 'Mitochondria', 'Osmolar Concentration', 'Potassium', 'Reproduction', 'Sodium', 'Sodium-Potassium-Exchanging ATPase'] | 23,124,947 | [['F01.145.113.069.500'], ['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D01.210.450.150', 'D01.248.497.158.215'], ['G16.500.275', 'N06.230'], ['B01.050.150.900.493'], ['G16.500.275.280', 'N06.230.232'], ['A13.421'], ['A11.284.430.214.190.875.564', 'A11.284.835.626'], ['G02.640'], ['D01.268.549.5... | ['Psychiatry and Psychology [F]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Urorectal septum malformation sequence: a report of seven cases. | Urorectal septum malformation (URSM) sequence is an extremely uncommon anomaly. We report herein seven cases of URSM sequence that were identified after reviewing all autopsies conducted at our hospital over a period of 26 years (1981-2006). The URSM spectrum includes partial and full URSM sequences. Absent perineal an... | ['Abnormalities, Multiple', 'Anus, Imperforate', 'Autopsy', 'Female', 'Humans', 'India', 'Infant, Newborn', 'Male', 'Pregnancy', 'Rectum', 'Syndrome', 'Urogenital Abnormalities'] | 18,983,585 | [['C16.131.077'], ['C06.198.050', 'C16.131.314.094'], ['E01.370.060', 'E05.070', 'I01.198.780.937.120'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.245.393'], ['M01.060.703.520'], ['G08.686.784.769'], ['A03.556.124.526.767', 'A03.556.249.249.767'], ['C23.550.288.500'], ['C12.706', 'C13.351.875', 'C16.13... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Geographicals [Z]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 |
Moderate intense physical activity depends on selected Metabolic Equivalent of Task (MET) cut-off and type of data analysis. | BACKGROUND: Accelerometry data are frequently analyzed without considering whether moderate-to-vigorous physical activities (MVPA) were performed in bouts of >10 minutes as defined in most physical activity guidelines. We aimed i) to quantify MVPA by using different commonly-applied physical activity guidelines, ii) to... | ['Accelerometry', 'Cross-Sectional Studies', 'Humans', 'Likelihood Functions', 'Motor Activity', 'Pulmonary Disease, Chronic Obstructive', 'ROC Curve', 'Retrospective Studies', 'Sensitivity and Specificity', 'Spirometry', 'Statistics, Nonparametric', 'Time Factors'] | 24,376,804 | [['E05.003'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.475', 'E05.318.740.600.400', 'E05.599.835.500', 'N05.715.360.750.530.450', 'N05.715.360.750.625.450', 'N06.850.520.830.500.475', 'N06.850.520.830.600.400'], ['F... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Differential contributions of the globus pallidus and ventral thalamus to stimulus-response learning in humans. | The ability to learn associations between stimuli, responses and rewards is a prerequisite for survival. Models of reinforcement learning suggest that the striatum, a basal ganglia input nucleus, vitally contributes to these learning processes. Our recently presented computational model predicts, first, that not only t... | ['Adult', 'Aged', 'Association Learning', 'Brain Waves', 'Female', 'Globus Pallidus', 'Humans', 'Male', 'Middle Aged', 'Models, Neurological', 'Psychomotor Performance', 'Reward', 'Ventral Thalamic Nuclei', 'Young Adult'] | 26,220,740 | [['M01.060.116'], ['M01.060.116.100'], ['F02.463.425.069.296'], ['E01.370.376.300.150', 'E01.370.405.245.287', 'G07.265.087', 'G11.561.127'], ['A08.186.211.200.885.287.249.487.397'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.599.395.642'], ['F02.808', 'G11.427.700', 'G11.561.660'], ['F... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Role of permanent atrial fibrillation (AF) on long-term mortality in community-dwelling elderly people with and without chronic heart failure (CHF). | Permanent AF is characterized by an increased mortality in elderly subjects with CHF. Moreover, AF increased the risk of mortality also in elderly subjects without CHF. Thus, we examined long-term mortality in community-dwelling elderly people with and without CHF. A total of 1332 subjects aged 65 and older were select... | ['Aged', 'Aged, 80 and over', 'Atrial Fibrillation', 'Cause of Death', 'Chronic Disease', 'Female', 'Heart Failure', 'Humans', 'Italy', 'Male', 'Residence Characteristics', 'Severity of Illness Index'] | 21,722,972 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['C14.280.067.198', 'C23.550.073.198'], ['E05.318.308.985.550.250', 'N01.224.935.698.100', 'N06.850.505.400.975.550.250', 'N06.850.520.308.985.550.250'], ['C23.550.291.500'], ['C14.280.434'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.542.489'], ['N01.224.791',... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Psychiatric aspects of learning difficulties. | This article describes the process of clinical assessment that may lead to differential treatment of psychiatric-related learning difficulties. The authors review differences in information processing among individuals with attention, affective, and primary thought disorders. | ['Adult', 'Anxiety', 'Anxiety Disorders', 'Anxiety, Separation', 'Child', 'Child Behavior Disorders', 'Child Psychiatry', 'Cognition', 'Depression', 'Developmental Disabilities', 'Dexamethasone', 'Dyslexia', 'Humans', 'Language Development Disorders', 'Learning', 'Learning Disabilities', 'Schizophrenia, Childhood', 'So... | 6,203,090 | [['M01.060.116'], ['F01.470.132'], ['F03.080'], ['F03.080.300', 'F03.625.047'], ['M01.060.406'], ['F03.625.141'], ['F04.096.544.193', 'H02.403.690.130'], ['F02.463.188'], ['F01.145.126.350'], ['F03.625.421'], ['D04.210.500.745.432.769.344', 'D04.210.500.908.238'], ['C10.597.606.150.500.300', 'C10.597.606.150.550.200', ... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
AIDS and Africa. Introduction. | Sub-Saharan Africa is the epicenter of the HIV/AIDS epidemic, and in this issue of the Journal, seven authors discuss the moral, social and medical implications of having 70% of those stricken living in this area. Anton A. van Niekerk considers complexities of plague in this region (poverty, denial, poor leadership, il... | ['Acquired Immunodeficiency Syndrome', 'Africa South of the Sahara', 'Bioethics', 'Delivery of Health Care', 'Disease Outbreaks', 'Ethics', 'Female', 'Humans', 'Internationality', 'Male', 'Politics', 'Poverty', 'Prejudice', 'Public Health', 'Social Problems'] | 11,961,693 | [['C01.221.250.875.040', 'C01.221.812.640.400.040', 'C01.778.640.400.040', 'C01.925.782.815.616.400.040', 'C01.925.813.400.040', 'C01.925.839.040', 'C20.673.480.040'], ['Z01.058.290'], ['K01.752.566.479.045', 'N05.350.200'], ['N04.590.374', 'N05.300'], ['N06.850.290'], ['K01.752.566.479', 'N05.350'], ['B01.050.150.900.... | ['Diseases [C]', 'Geographicals [Z]', 'Humanities [K]', 'Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Psychiatry and Psychology [F]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 |
Heterologous co-production of Thermobifida fusca Cel9A with other cellulases in Saccharomyces cerevisiae. | The processive endoglucanase Cel9A of the moderately thermophilic actinomycete Thermobifida fusca was functionally produced in Saccharomyces cerevisiae. Recombinant Cel9A displayed activity on both soluble (carboxymethylcellulose) and insoluble (Avicel) cellulose substrates confirming its processive endoglucanase activ... | ['Actinomycetales', 'Bacterial Proteins', 'Cellulases', 'Cellulose', 'Chromatography, Ion Exchange', 'Fungal Proteins', 'Glucose', 'Recombinant Proteins', 'Saccharomyces cerevisiae', 'Trichoderma'] | 20,449,742 | [['B03.510.024.049'], ['D12.776.097'], ['D08.811.277.450.420.200'], ['D05.750.078.562.180', 'D09.698.365.180', 'D25.720.099.500', 'J01.637.051.720.099.500'], ['E05.196.181.400.383'], ['D12.776.354'], ['D09.947.875.359.448'], ['D12.776.828'], ['B01.300.107.795.785.800', 'B01.300.930.705.655'], ['B01.300.381.910']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
The influence of 7,12-dimethylbenzanthracene on natural killer (NK) cell function in rats. | The administration to 2 strains of rat (Alderley Park and Sprague Dawley) of 40 (2 X 20) mg of 7,12-dimethylbenzanthracene (DMBA) on a single day caused a transient depression of NK cell function. The splenic natural cytotoxic capacity of both DMBA treated and control animals was augmented by inclusion within the assay... | ['9,10-Dimethyl-1,2-benzanthracene', 'Animals', 'Cells, Cultured', 'Cytotoxicity, Immunologic', 'Female', 'Killer Cells, Natural', 'Lymphocyte Activation', 'Phytohemagglutinins', 'Rats', 'Rats, Inbred Strains', 'Species Specificity', 'Spleen'] | 3,093,684 | [['D02.455.426.559.847.149.301', 'D04.615.149.301'], ['B01.050'], ['A11.251'], ['G12.287'], ['A11.118.637.555.567.537', 'A15.145.229.637.555.567.537', 'A15.382.490.555.567.537'], ['E01.370.225.812.482', 'E05.200.812.482', 'E05.478.594.530', 'G12.450.050.400.545', 'G12.565'], ['D12.776.395.560.825', 'D12.776.503.499.750... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Impaired mitochondrial function in murine oocytes is associated with controlled ovarian hyperstimulation and in vitro maturation. | The present study was designed to determine whether controlled ovarian hyperstimulation (COH) and in vitro maturation (IVM), two common clinical procedures in human IVF treatment, have an impact on mitochondrial DNA (mtDNA) copy number and mitochondrial function in oocytes. Matured mouse oocytes recovered following COH... | ['Adenosine Triphosphate', 'Animals', 'Chorionic Gonadotropin', 'Cytoskeleton', 'DNA Replication', 'DNA, Mitochondrial', 'Female', 'Fertility Agents, Female', 'Gonadotropins, Equine', 'In Vitro Oocyte Maturation Techniques', 'Membrane Potential, Mitochondrial', 'Mice', 'Mitochondria', 'Oocytes', 'Ovulation Induction', ... | 22,935,155 | [['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['B01.050'], ['D06.472.699.322.326', 'D06.472.699.649.367', 'D12.644.548.726.367', 'D12.776.780.400'], ['A11.284.430.214.190.750'], ['G02.111.225', 'G05.226'], ['D13.444.308.283.225'], ['D27.505.696.875.552.344', 'D27.505.954.705.552.344'],... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Comparative study on the percentage of recovery, survival and mode of sequestration of fresh and frozen preserved (-196 degrees C) human platelets. | Platelet concentrates amounting to 142 X 10(9) +/- 11 X 10(9) cells are prepared by cytopheresis from one liter of blood. Ten of the concentrates are labelled with 51Cr and reinfused autologously. The other ten concentrates are frozen with a controlled rate freezer in a medium containing 10% DMSO and 5% glucose for 7 d... | ['Blood Platelets', 'Blood Preservation', 'Blood Transfusion, Autologous', 'Cell Survival', 'Chromium Radioisotopes', 'Freezing', 'Humans', 'In Vitro Techniques', 'Liver', 'Myocardium', 'Platelet Transfusion', 'Shock', 'Spleen'] | 6,182,072 | [['A11.118.188', 'A15.145.229.188'], ['E02.792.833.230', 'E05.760.833.230'], ['E02.095.135.164'], ['G04.346'], ['D01.268.556.175.500.349', 'D01.268.956.124.500.349', 'D01.496.212.349', 'D01.496.749.213', 'D01.552.544.175.500.349'], ['G01.645.500', 'G01.906.595.272.437', 'G02.734.466'], ['B01.050.150.900.649.313.988.400... | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A two-state Raman coupler for coherent atom optics. | We present results on a Raman laser-system that resonantly drives a closed two-photon transition between two levels in different hyperfine ground states of (87)Rb. The coupler is based on a novel optical design for producing two phase-coherent optical beams to drive a Raman transition. Operated as an outcoupler, it pro... | ['Computer-Aided Design', 'Equipment Design', 'Equipment Failure Analysis', 'Interferometry', 'Lasers, Semiconductor', 'Refractometry', 'Reproducibility of Results', 'Sensitivity and Specificity', 'Spectrum Analysis, Raman'] | 19,219,134 | [['L01.224.108.150', 'L01.296.110.150'], ['E05.320'], ['E05.325.192'], ['E05.490'], ['E07.632.490.480', 'E07.710.520.480'], ['E05.196.808', 'H01.671.617.755'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700', 'N05.... | ['Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Stochastic late accretion to Earth, the Moon, and Mars. | Core formation should have stripped the terrestrial, lunar, and martian mantles of highly siderophile elements (HSEs). Instead, each world has disparate, yet elevated HSE abundances. Late accretion may offer a solution, provided that ?0.5% Earth masses of broadly chondritic planetesimals reach Earth's mantle and that ~... | ['Earth, Planet', 'Elements', 'Evolution, Planetary', 'Extraterrestrial Environment', 'Mars', 'Meteoroids', 'Minor Planets', 'Moon', 'Water'] | 21,148,387 | [['G01.060.075.730.700.200'], ['D01.268'], ['G01.060.275', 'G01.311.290'], ['G01.060.075.159', 'G16.500.275.240'], ['G01.060.075.730.700.625'], ['G01.060.075.500'], ['G01.060.075.730.600'], ['G01.060.075.730.700.200.500'], ['D01.045.250.875', 'D01.248.497.158.459.650', 'D01.650.550.925']] | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Compartmentation of glycolysis and glycogenolysis in the perfused rat heart. | Developing methods that can detect compartmentation of metabolic pathways in intact tissues may be important for understanding energy demand and supply. In this study, we investigated compartmentation of glycolysis and glycogenolysis in the isolated perfused rat heart using (13)C NMR isotopomer analysis. Rat hearts pre... | ['Animals', 'Energy Metabolism', 'Glucagon', 'Glucose', 'Glutamic Acid', 'Glycogen', 'Glycolysis', 'Heart', 'Lactic Acid', 'Magnetic Resonance Spectroscopy', 'Male', 'Myocardium', 'Pyruvic Acid', 'Rats', 'Rats, Sprague-Dawley', 'Signal Transduction'] | 15,052,552 | [['B01.050'], ['G03.295'], ['D06.472.699.587.730.500', 'D12.644.548.586.730.500'], ['D09.947.875.359.448'], ['D12.125.067.625.349', 'D12.125.119.409.349', 'D12.125.427.300'], ['D05.750.078.562.388', 'D09.698.365.388'], ['G02.111.158.750', 'G03.191.750', 'G03.295.436', 'G03.493.360'], ['A07.541'], ['D02.241.511.459.450'... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
WG "Freiberufliche osteoanthropologen" (AFOA). | Due to a continuous process of dismantling within the university system, the number of freelance anthropologists has increased. In 2011 a group of experienced anthropologists founded the "Workgroup Freelance Osteoanthropologists (AFOA)". Its members developed a codex and guidelines in order to ensure a high quality for... | ['Anthropology, Physical', 'Education', 'Humans', 'Universities'] | 24,818,446 | [['I01.076.368'], ['I02'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I02.783.830', 'J03.832.830']] | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 |
Identification and characterization of human PMP34, a protein closely related to the peroxisomal integral membrane protein PMP47 of Candida boidinii. | The cDNA of a human protein displaying 33% identity to the peroxisomal integral membrane protein PMP47 of Candida boidinii (CbPMP47) was cloned. It encodes a protein of 307 amino acids, with a calculated molecular mass of 34,566 Da. The protein, which we name HsPMP34, contains six membrane spans and belongs, like PMP47... | ['Acetyl-CoA C-Acetyltransferase', 'Amino Acid Sequence', 'Animals', 'Base Sequence', 'Biological Transport', 'Candida', 'Cell Line', 'Chromosome Mapping', 'Chromosomes, Human, Pair 22', 'Cloning, Molecular', 'Fungal Proteins', 'Humans', 'Membrane Proteins', 'Mice', 'Microbodies', 'Microscopy, Fluorescence', 'Molecular... | 9,874,197 | [['D08.811.913.050.134.025'], ['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G03.143'], ['B01.300.107.795.095', 'B01.300.381.147', 'B01.300.930.176'], ['A11.251.210'], ['E05.393.183'], ['A11.284.187.520.300.505.515', 'G05.360.162.520.300.505.515'], ... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Screening of high-risk and general populations for gestational diabetes. Clinical application and cost analysis. | Two thousand seventy-seven women attending a university-based prenatal clinic were screened for gestational diabetes. The patients were divided into two groups. Group 1 consisted of 959 patients with historic or clinical factors traditionally employed to identify patients as being at high risk for the occurrence of ges... | ['Costs and Cost Analysis', 'Female', 'Gestational Age', 'Glucose Tolerance Test', 'Humans', 'Mass Screening', 'Pregnancy', 'Pregnancy in Diabetics', 'Risk'] | 3,996,767 | [['N03.219.151'], ['G07.345.500.325.235.968', 'G08.686.320'], ['E01.370.225.124.100.355', 'E01.370.374.355', 'E05.200.124.100.355'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.500', 'E05.318.308.980.438.580', 'N02.421.726.233.443', 'N05.715.360.300.800.438.500', 'N06.850.520.308.980.438.580', 'N06.850.7... | ['Health Care [N]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Teratogenic assessment of three methylated hydrazine derivatives in the rat. | The embryotoxicity and teratogenicity of methylhydrazine, 1,1-dimethylhydrazine, and 1,2-dimethylhydrazine were investigated with pregnant Fischer-344 rats. The compounds were administered ip on d 6-15 of pregnancy. A dose-dependent reduction in maternal weight gains occurred for all three compounds. A dose-related ter... | ['1,2-Dimethylhydrazine', 'Animals', 'Body Weight', 'Dimethylhydrazines', 'Female', 'Fetal Resorption', 'Injections, Intraperitoneal', 'Methylhydrazines', 'Monomethylhydrazine', 'Pregnancy', 'Rats', 'Rats, Inbred F344', 'Teratogens'] | 6,716,510 | [['D02.442.600.400.200'], ['B01.050'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['D02.442.600.400'], ['C13.703.223.300', 'C23.550.260.585.260'], ['E02.319.267.530.490'], ['D02.442.600'], ['D02.442.600.601'], ['G08.686.784.769'], ['B01.050.150.9... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nurses' knowledge to identify early acute kidney injury. | OBJECTIVE: To evaluate the knowledgeof nurses on early identification of acute kidney injury (AKI) in intensive care, emergency and hospitalization units.METHOD: A prospective multi-center study was conducted with 216 nurses, using a questionnaire with 10 questions related to AKI prevention, diagnosis, and treatment.RE... | ['Acute Kidney Injury', 'Adult', 'Clinical Competence', 'Cross-Sectional Studies', 'Early Diagnosis', 'Female', 'Humans', 'Male', 'Middle Aged', 'Nursing Diagnosis', 'Prospective Studies', 'Self Report', 'Young Adult'] | 27,556,709 | [['C12.777.419.780.050', 'C13.351.968.419.780.050'], ['M01.060.116'], ['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['E01.390'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['N04.590.233.508.480.110'], ['E05.31... | ['Diseases [C]', 'Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
On the conformation of the COOH-terminal domain of the large mechanosensitive channel MscL. | COOH-terminal (S3) domains are conserved within the MscL family of bacterial mechanosensitive channels, but their function remains unclear. The X-ray structure of MscL from Mycobacterium tuberculosis (TbMscL) revealed cytoplasmic domains forming a pentameric bundle (Chang, G., R.H. Spencer, A.T. Lee, M.T. Barclay, and ... | ['Amino Acid Sequence', 'Amino Acid Substitution', 'Biomarkers', 'Cell Line', 'Cell Survival', 'Computer Simulation', 'Cysteine', 'Cytoplasm', 'Dithiothreitol', 'Dose-Response Relationship, Drug', 'Electric Conductivity', 'Escherichia coli Proteins', 'Hydrogen Peroxide', 'Ion Channel Gating', 'Ion Channels', 'Models, M... | 12,601,086 | [['G02.111.570.060', 'L01.453.245.667.060'], ['E05.393.420.601.035', 'G05.558.109'], ['D23.101'], ['A11.251.210'], ['G04.346'], ['L01.224.160'], ['D02.886.030.230', 'D02.886.489.155', 'D12.125.154.299', 'D12.125.166.230'], ['A11.284.430.214'], ['D02.033.800.196', 'D02.886.740.224', 'D09.853.196'], ['G07.690.773.875', '... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
An inexpensive drivable cannulated microelectrode array for simultaneous unit recording and drug infusion in the same brain nucleus of behaving rats. | Neurons are functionally segregated into discrete populations that perform specific computations. These computations, mediated by neuron-neuron electrochemical signaling, form the neural basis of behavior. Thus fundamental to a brain-based understanding of behavior is the precise determination of the contribution made ... | ['Animals', 'Behavior, Animal', 'Brain', 'Catheterization', 'Electrodes, Implanted', 'Infusion Pumps', 'Lidocaine', 'Male', 'Microelectrodes', 'Microinjections', 'Rats', 'Rats, Long-Evans'] | 21,613,588 | [['B01.050'], ['F01.145.113'], ['A08.186.211'], ['E02.148', 'E05.157'], ['E07.305.250.319', 'E07.695.202'], ['E07.505', 'E07.858.082.505'], ['D02.065.199.092.500', 'D02.092.146.113.092.500'], ['E07.305.250.500'], ['E02.319.267.530.690', 'E05.591.570'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.... | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
North-South divide: contrasting impacts of climate change on crop yields in Scotland and England. | Effects of climate change on productivity of agricultural crops in relation to diseases that attack them are difficult to predict because they are complex and nonlinear. To investigate these crop-disease-climate interactions, UKCIP02 scenarios predicting UK temperature and rainfall under high- and low-CO(2) emission sc... | ['Climate', 'Climate Change', 'Computer Simulation', 'Crops, Agricultural', 'Ecosystem', 'England', 'Models, Biological', 'Scotland'] | 19,447,817 | [['G16.500.275.071', 'N06.230.300.100.250'], ['G16.500.175.374'], ['L01.224.160'], ['B01.650.160', 'G07.203.300.300', 'J02.500.300'], ['G16.500.275.157', 'N06.230.124'], ['Z01.542.363.300'], ['E05.599.395'], ['Z01.542.363.766']] | ['Phenomena and Processes [G]', 'Health Care [N]', 'Information Science [L]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 |
Structure and chromosome assignment of the murine p36 (calpactin I heavy chain) gene. | p36 is a major substrate of both viral and growth factor receptor associated protein kinases. This protein has recently been named calpactin I heavy chain since it is the large subunit of a Ca2(+)-dependent phospholipid and actin binding heterotetramer. The primary structure of p36 has been determined from analysis of ... | ['Amino Acid Sequence', 'Animals', 'Annexins', 'Base Sequence', 'Calcium-Binding Proteins', 'Chromosome Deletion', 'Chromosome Mapping', 'Cricetinae', 'DNA', 'Exons', 'Gene Expression', 'Introns', 'Mice', 'Molecular Sequence Data', 'Repetitive Sequences, Nucleic Acid', 'Restriction Mapping'] | 2,138,915 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D12.776.157.125.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D12.776.157.125'], ['C23.550.210.050.500.500', 'G05.365.590.029.530.175', 'G05.365.590.175.050.500.500', 'G05.365.590.762.180', 'G05.558.800.180', 'G05.700.131.500.500'], ['E05... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Antibodies to Newcastle disease virus in the sera of indigenous chickens in Oodi, Kgatleng, Botswana. | A serological survey was conducted to determine the prevalence of antibodies to Newcastle disease virus in apparently healthy and unvaccinated adult indigenous chickens. Haemagglutination inhibiting antibodies to Newcastle disease virus were found in the sera of 51 out of 89 (57.3%) chickens sampled. | ['Animals', 'Antibodies, Viral', 'Botswana', 'Chickens', 'Newcastle Disease', 'Newcastle disease virus', 'Seroepidemiologic Studies'] | 11,403,432 | [['B01.050'], ['D12.776.124.486.485.114.254', 'D12.776.124.790.651.114.254', 'D12.776.377.715.548.114.254'], ['Z01.058.290.175.230'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['C01.925.782.580.600.080.600', 'C22.131.630'], ['B04.820.480.937.600.650.070.600'], ['E05.318.372.500.950', 'N05.715.360.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Increase in plasma thrombin-activatable fibrinolysis inhibitor may not contribute to thrombotic tendency in antiphospholipid syndrome because of inhibitory potential of antiphospholipid antibodies toward TAFI activation. | The causes of thrombosis in antiphospholipid syndrome (APS) remain unknown, though several hypotheses in regard to hypofibrinolysis have been proposed. To clarify the mechanism, we measured plasma levels of thrombin-activatable fibrinolysis inhibitor (TAFI) in APS patients. Both the TAFI antigen (TAFI:Ag) level measure... | ['Adult', 'Aged', 'Antibodies, Antiphospholipid', 'Antiphospholipid Syndrome', 'Carboxypeptidase B2', 'Female', 'Humans', 'Lupus Erythematosus, Systemic', 'Male', 'Middle Aged', 'Risk Factors', 'Thrombosis'] | 20,490,730 | [['M01.060.116'], ['M01.060.116.100'], ['D12.776.124.486.485.114.323.210', 'D12.776.124.790.651.114.323.210', 'D12.776.377.715.548.114.323.210'], ['C20.111.197'], ['D08.811.277.656.350.245.125', 'D08.811.277.656.350.555.225', 'D08.811.277.656.675.555.225', 'D08.811.277.656.837.092'], ['B01.050.150.900.649.313.988.400.1... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Effect of ACTH and histamine stress on serum corticosterone and adrenal cyclic AMP levels in immature rats. | Adrenal cAMP and plasma corticosterone levels were determined in pre-weanling rats subjected to treatment with either ACTH (50 mU/rat) or histamine dihydrochloride (0.2 mg/g body wt). ACTH injection elevated both serum corticosterone and adrenal cAMP levels on all days tested. However, the ACTH-induced elevation of adr... | ['Adrenal Glands', 'Adrenocorticotropic Hormone', 'Age Factors', 'Animals', 'Animals, Newborn', 'Corticosterone', 'Cyclic AMP', 'Female', 'Histamine', 'Male', 'Rats', 'Stimulation, Chemical', 'Stress, Physiological'] | 164,340 | [['A06.300.071'], ['D06.472.699.327.935.531.500', 'D06.472.699.631.525.600.531.500', 'D12.644.400.400.935.531.500', 'D12.644.548.365.935.531.500', 'D12.644.548.691.525.690.531.500', 'D12.776.631.650.405.935.531.500'], ['N05.715.350.075', 'N06.850.490.250'], ['B01.050'], ['B01.050.050.282'], ['D04.210.500.745.745.654.23... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Nonablative allogeneic hematopoietic transplantation as adoptive immunotherapy for indolent lymphoma: low incidence of toxicity, acute graft-versus-host disease, and treatment-related mortality. | This study investigated the use of a nonablative conditioning regimen to decrease toxicity and achieve engraftment of an allogeneic blood stem cell transplant, allowing a graft-versus-malignancy effect to occur. All patients had follicular or small cell lymphocytic lymphoma after relapse from a prior response to conven... | ['Adult', 'Aged', 'Antibodies, Monoclonal', 'Antibodies, Monoclonal, Murine-Derived', 'Cyclophosphamide', 'Female', 'Graft Survival', 'Graft vs Host Disease', 'Graft vs Tumor Effect', 'Hematopoietic Stem Cell Transplantation', 'Humans', 'Immunosuppressive Agents', 'Immunotherapy, Adoptive', 'Leukemia, Lymphocytic, Chro... | 11,739,162 | [['M01.060.116'], ['M01.060.116.100'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D12.776.124.486.485.114.224.075', 'D12.776.124.790.651.114.224.075', 'D12.776.377.715.548.114.224.284'], ['D02.455.526.728.650.730.243', 'D02.705.672.500.243'], ['G12.875.545.340'], ['... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Apolipoprotein D inhibits platelet-derived growth factor-BB-induced vascular smooth muscle cell proliferated by preventing translocation of phosphorylated extracellular signal regulated kinase 1/2 to the nucleus. | OBJECTIVE: Elevated apolipoprotein D (apoD) levels are associated with reduced proliferation of cancer cells. We therefore investigated whether apoD, which occurs free or associated with HDL, suppresses vascular smooth muscle cell (VSMC) proliferation, which is related to the pathobiology of disease.METHODS AND RESULTS... | ['Animals', 'Aorta', 'Apolipoproteins', 'Apolipoproteins D', 'Arteriosclerosis', 'Becaplermin', 'Cell Division', 'Cells, Cultured', 'Coronary Vessels', 'Mitogen-Activated Protein Kinase 1', 'Mitogen-Activated Protein Kinase 3', 'Mitogen-Activated Protein Kinases', 'Muscle, Smooth, Vascular', 'Phosphorylation', 'Platele... | 14,551,159 | [['B01.050'], ['A07.015.114.056'], ['D10.532.091', 'D12.776.070.400', 'D12.776.521.120'], ['D10.532.091.450', 'D12.776.070.400.450', 'D12.776.521.120.450'], ['C14.907.137.126'], ['D12.644.276.910.650.500', 'D12.776.260.690.500', 'D12.776.467.910.650.500', 'D23.529.910.650.500'], ['G04.144.220', 'G04.161.750.500', 'G05.... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Intratumoral DNA content variability. A study of non-small cell lung cancer. | Twenty-eight resected primary non-small cell lung carcinomas were studied for intratumoral DNA variability by flow cytometry (FCM). Three separate tissue specimens from each resected tumor were divided equally for FCM analysis and histologic evaluation. FCM analysis also was performed on fine-needle aspirates (FNAs) fr... | ['Adenocarcinoma', 'Aged', 'Biopsy, Needle', 'Carcinoma, Non-Small-Cell Lung', 'Carcinoma, Squamous Cell', 'DNA, Neoplasm', 'Female', 'Flow Cytometry', 'Humans', 'Lung Neoplasms', 'Male', 'Middle Aged', 'Ploidies', 'RNA, Neoplasm'] | 1,652,200 | [['C04.557.470.200.025'], ['M01.060.116.100'], ['E01.370.225.500.384.100.119', 'E01.370.225.998.054.119', 'E01.370.388.100.100', 'E04.074.119', 'E04.665.100', 'E05.200.500.384.100.119', 'E05.200.998.054.119', 'E05.242.384.100.119'], ['C04.588.894.797.520.109.220.249', 'C08.381.540.140.500', 'C08.785.520.100.220.500'], ... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Neuroanatomical and histochemical evidence for the presence of common lateral line and inner ear efferents and of efferents to the basilar papilla in a frog, Xenopus laevis. | The claimed absence of efferents to the basilar papilla in frogs was reexamined in Xenopus laevis with the use of acetylcholinesterase (AChE) histochemistry. We also tested the presence of common lateral line and inner ear efferents by employing neuroanatomical tract tracing techniques. Our data show some AChE-positive... | ['Acetylcholinesterase', 'Afferent Pathways', 'Animals', 'Basilar Membrane', 'Biological Evolution', 'Brain Stem', 'Cranial Nerves', 'Ear, Inner', 'Efferent Pathways', 'Metamorphosis, Biological', 'Microscopy, Electron', 'Species Specificity', 'Xenopus laevis'] | 9,156,781 | [['D08.811.277.352.100.170.176'], ['A08.612.220'], ['B01.050'], ['A09.246.300.246.125', 'A10.615.179.124'], ['G05.045', 'G16.075'], ['A08.186.211.132'], ['A08.800.800.120'], ['A09.246.300'], ['A08.612.380'], ['G07.345.500.550'], ['E01.370.350.515.402', 'E05.595.402'], ['G16.824'], ['B01.050.150.900.090.180.610.500.562'... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Influence of xylazine on the function of the LiDCO sensor in isoflurane anaesthetized horses. | OBJECTIVE: Previous studies showed an influence of xylazine on the LiDCO sensor in vitro and in standing horses, but did not prove that this interaction caused error in LiDCO measurements. Therefore, agreement of cardiac output (CO) measurements by LiDCO and bolus-thermodilution (BTD) was determined in horses receiving... | ['Anesthesia, Inhalation', 'Anesthetics, Inhalation', 'Animals', 'Cardiac Output', 'Female', 'Horses', 'Isoflurane', 'Male', 'Muscle Relaxants, Central', 'Thermodilution', 'Xylazine'] | 24,890,704 | [['E03.155.197.197'], ['D27.505.696.277.100.035.060', 'D27.505.954.427.210.100.035.060'], ['B01.050'], ['E01.370.370.380.150', 'G09.330.380.124'], ['B01.050.150.900.649.313.984.235.472'], ['D02.355.601.570'], ['D27.505.696.510', 'D27.505.696.663.700.600', 'D27.505.954.427.525'], ['E05.484.750'], ['D02.886.665.985', 'D0... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Distribution and structure-function relationship of myosin heavy chain isoforms in the adult mouse heart. | The two cardiac myosin heavy chain isoforms, alpha and beta, exhibit distinct functional characteristics and therefore may be distributed regionally within the heart to match the functional demands of a specific region. In adult mouse hearts, which predominantly express alpha-myosin heavy chain, we observed high concen... | ['Adenosine Triphosphatases', 'Animals', 'Mice', 'Myocardium', 'Myosin Heavy Chains', 'Protein Isoforms', 'Recombinant Fusion Proteins', 'Tissue Distribution', 'Ventricular Myosins'] | 17,575,272 | [['D08.811.277.040.025'], ['B01.050'], ['B01.050.150.900.649.313.992.635.505.500'], ['A02.633.580', 'A07.541.704', 'A10.690.552.750'], ['D05.750.078.730.475.100', 'D08.811.277.040.025.193.750.249', 'D12.776.210.500.600.100', 'D12.776.220.525.475.100'], ['D12.776.800'], ['D12.776.828.300'], ['G03.787.917', 'G07.690.725.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The effects of increasing consonant/vowel intensity ratio on speech loudness. | It was hypothesized that speech loudness may be primarily determined by the level of the vowel and that, as a consequence, high positive consonant/vowel intensity ratios (C/V ratios) could be tolerated by hearing-impaired listeners with possible improvement in intelligibility. The present study was concerned with the e... | ['Adult', 'Deafness', 'Hearing Aids', 'Hearing Loss, High-Frequency', 'Hearing Loss, Noise-Induced', 'Humans', 'Loudness Perception', 'Microcomputers', 'Phonetics', 'Software', 'Speech Acoustics', 'Speech Perception'] | 3,430,381 | [['M01.060.116'], ['C09.218.458.341.186', 'C10.597.751.418.341.186', 'C23.888.592.763.393.341.186'], ['E07.305.906.500', 'E07.814.458'], ['C09.218.458.341.812', 'C10.597.751.418.341.812', 'C23.888.592.763.393.341.812'], ['C09.218.458.341.887.460', 'C10.597.751.418.341.887.460', 'C23.888.592.763.393.341.887.460'], ['B01... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Information Science [L]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
Anatomical, Phytochemical, and Histochemical Study of Juniperus rigida | Needles of Juniperus rigida are used in Chinese traditional medicine for the treatment of brucellosis, dropsy, skin disease, and rheumatoid arthritis. This is the first study that reports anatomical structures of the J. rigida needles collected at different altitudes. The most common anatomical, phytochemical, and hist... | ['Altitude', 'Histocytochemistry', 'Juniperus', 'Phenols', 'Phytochemicals', 'Plant Epidermis', 'Plant Leaves', 'Terpenes'] | 31,451,123 | [['G16.500.275.058', 'N06.230.058'], ['E01.370.225.500.607', 'E01.370.225.750.551', 'E05.200.500.607', 'E05.200.750.551', 'H01.158.100.656.234', 'H01.158.201.344', 'H01.181.122.573'], ['B01.650.940.800.575.912.625.750.500'], ['D02.455.426.559.389.657'], ['D23.704'], ['A18.024.750'], ['A18.024.812'], ['D02.455.849']] | ['Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Detection of ocular malignancies. | The case notes of new patients attending the oncology clinic at Moorfields Eye Hospital during the first 5 months of 1988 were analysed retrospectively with regard to the origin of the primary referral, the presence of symptoms, the diagnosis and management. Sixty-eight of 94 new patients were diagnosed as having malig... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Child', 'Child, Preschool', 'Choroid Neoplasms', 'Ciliary Body', 'Community Health Services', 'Conjunctival Neoplasms', 'Eye Neoplasms', 'Humans', 'Infant', 'Iris Neoplasms', 'Melanoma', 'Middle Aged', 'Referral and Consultation', 'Retrospective Studies', 'Uveal Neo... | 2,325,059 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['M01.060.406'], ['M01.060.406.448'], ['C04.588.364.978.223', 'C11.319.494.198', 'C11.941.160.238', 'C11.941.855.198'], ['A09.371.060.160', 'A09.371.894.280'], ['N02.421.143'], ['C04.588.364.235', 'C11.187.169', 'C11.319.217'], ['C04.588.3... | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Convenient pd-catalyzed synthesis of large unimolecular star polyethylene nanoparticles. | A simplistic convenient "arm-first" catalytic synthesis method is demonstrated to render soft unimolecular star polyethylene nanoparticles. Low-dispersity polyethylene arms of controllable length and topology are first synthesized via Pd-catalyzed "living" ethylene poly-merization. The subsequent addition of norbornadi... | ['Catalysis', 'Magnetic Resonance Spectroscopy', 'Nanoparticles', 'Norbornanes', 'Particle Size', 'Polyethylene', 'Polymers'] | 24,030,963 | [['G02.130'], ['E05.196.867.519'], ['J01.637.512.600'], ['D02.455.426.100.080.550', 'D04.075.080.500'], ['G02.712'], ['D02.455.326.271.665.550.500', 'D05.750.716.507.500', 'D25.720.716.507.500', 'J01.637.051.720.716.507.500'], ['D05.750', 'D25.720', 'J01.637.051.720']] | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
A model to predict the improvement of automated blood culture bacterial detection by doubling platelet sample volume. | BACKGROUND: Some transmissions of bacterial infection from platelet (PLT) transfusion have occurred since introduction of automated blood culturing of apheresis PLTs. The majority of these cases involved false-negative culture results in which slow-growing Staphylococcus organisms were implicated. This study analyses t... | ['Automation', 'Bacteria', 'Blood', 'Blood Platelets', 'Blood Specimen Collection', 'Humans', 'Microbiological Techniques', 'Models, Statistical', 'Poisson Distribution'] | 17,319,822 | [['J01.897.104'], ['B03'], ['A12.207.152', 'A15.145'], ['A11.118.188', 'A15.145.229.188'], ['E01.370.225.998.110', 'E04.665.150', 'E05.200.998.110'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.875', 'E05.200.875'], ['E05.318.740.500', 'E05.599.835', 'N05.715.360.750.530', 'N06.850.520.830.500'], ['E... | ['Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
[The role of atrial natriuretic peptide in the pathogenesis of arterial hypertension in chronic glomerulonephritis]. | Radioimmunoassay was used in 39 patients with chronic glomerulonephritis and secondary hypertension to measure atrial natriuretic peptide concentration in blood plasma. The latter concentration appeared unrelated to the patients' age, duration and gravity of hypertension, the degree of renal insufficiency, hyperhydrati... | ['Adolescent', 'Adult', 'Atrial Natriuretic Factor', 'Blood Pressure', 'Chronic Disease', 'Female', 'Glomerulonephritis', 'Humans', 'Hypertension', 'Male', 'Middle Aged', 'Renin-Angiotensin System'] | 2,533,305 | [['M01.060.057'], ['M01.060.116'], ['D06.472.699.584.500', 'D12.644.548.585.500'], ['E01.370.600.875.249', 'G09.330.380.076'], ['C23.550.291.500'], ['C12.777.419.570.363', 'C13.351.968.419.570.363'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['M01.060.116.630'], ['G03.820', 'G09.330.380.813']] | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Relationship between serum estrogen and level of apolipoprotein E in human ovarian follicular fluid. | Apolipoprotein E (apoE) is an important effector of plasma lipoprotein due to its interaction with cell-surface receptors. In addition, it is secreted by rat and human ovarian granulosa cells in tissue culture, and its production is hormonally modulated. Such observations indicate that apoE should be found in human fol... | ['Apolipoproteins E', 'Estrogens', 'Female', 'Fertilization in Vitro', 'Follicle Stimulating Hormone', 'Humans', 'Ovarian Follicle'] | 2,494,081 | [['D10.532.091.500', 'D12.776.070.400.500', 'D12.776.521.120.500'], ['D27.505.696.399.472.277'], ['E02.875.800.750', 'E05.820.800.750'], ['D06.472.699.322.576.288', 'D06.472.699.631.525.343.288', 'D12.644.548.691.525.343.288'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A05.360.319.114.630.535', 'A06.300.312.49... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Protein structure in the truncated (2/2) hemoglobin family. | The discovery of protein sequences belonging to the widespread 'truncated hemoglobin' family has been followed in the last few years by extensive analyses of their three-dimensional structures. Truncated hemoglobins can be classified in three main groups, in light of their overall structural properties. The three group... | ['Hemoglobins', 'Ligands', 'Models, Molecular', 'Protein Binding', 'Proteins', 'Truncated Hemoglobins'] | 17,701,548 | [['D12.776.124.400', 'D12.776.422.316.762'], ['D27.720.470.480'], ['E05.599.595'], ['G02.111.679', 'G03.808'], ['D12.776'], ['D12.776.422.316.762.932']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Rat liver macrophages will not phagocytose fibrin during disseminated intravascular coagulation. | Disseminated intravascular coagulation was induced in rats by injection of a silver colloid suspension or thrombin. Ten min after the injection of colloid, fibrin deposits were observed light microscopically in all major organs. At 30 min, fibrin was no longer present. In rats treated with antifibrinolytics (epsilon-am... | ['Animals', 'Colloids', 'Disseminated Intravascular Coagulation', 'Female', 'Fibrin', 'Fibrinolysis', 'Kupffer Cells', 'Liver', 'Macrophages', 'Male', 'Phagocytosis', 'Rats', 'Silver', 'Thrombin'] | 1,002,004 | [['B01.050'], ['D20.280', 'D26.255.165'], ['C15.378.100.220', 'C15.378.463.250', 'C15.378.925.220'], ['D12.776.124.270'], ['G09.188.390.150.390'], ['A11.329.372.588', 'A11.627.482.588', 'A11.733.397.588', 'A15.382.670.522.588', 'A15.382.680.397.588'], ['A03.620'], ['A11.329.372', 'A11.627.482', 'A11.733.397', 'A15.382.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Influence of end-stage renal failure on concentrations of free apolipoprotein A-1 in serum. | We determined, immunoturbidimetrically, the concentrations of apolipoprotein A-I (apo A-I) (a) in total serum, (b) in total lipoproteins, and (c) in the fraction of d greater than 1.21 kg/L (free apo A-I) in 31 uremic patients (16 on hemodialysis, HD, and 15 with end-stage renal failure, ESRF) and 14 control subjects. ... | ['Adult', 'Apolipoprotein A-I', 'Apolipoproteins A', 'Arteriosclerosis', 'Cholesterol, HDL', 'Female', 'Humans', 'Immunologic Techniques', 'Kidney Failure, Chronic', 'Male', 'Middle Aged', 'Nephelometry and Turbidimetry', 'Uremia'] | 2,499,432 | [['M01.060.116'], ['D10.532.091.200.100', 'D12.776.070.400.200.100', 'D12.776.521.120.200.100'], ['D10.532.091.200', 'D12.776.070.400.200', 'D12.776.521.120.200'], ['C14.907.137.126'], ['D04.210.500.247.808.197.238', 'D10.532.432.400', 'D10.570.938.208.270', 'D12.776.521.479.470'], ['B01.050.150.900.649.313.988.400.112... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Speech disturbance at stroke onset is correlated with stroke early mortality. | BACKGROUND: Speech disturbance is a common symptom of stroke and is important as a prompt identifier of the event. The frequency of the symptom among each stroke subtype, differences between patients with and without speech disturbance and its correlation to early mortality remain unclear.METHODS: The Kyoto prefecture ... | ['Aged', 'Aged, 80 and over', 'Cerebral Infarction', 'Female', 'Humans', 'Kaplan-Meier Estimate', 'Male', 'Middle Aged', 'Odds Ratio', 'Speech Disorders', 'Stroke'] | 23,855,651 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['C10.228.140.300.150.477.200', 'C10.228.140.300.775.200.200', 'C14.907.253.092.477.200', 'C14.907.253.855.200.200', 'C23.550.513.355.250.200', 'C23.550.717.489.250.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.998.650', 'N05.715.360.750.795.650', '... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Engineering a composite neotrachea with surgical adhesives. | BACKGROUND/PURPOSE: Reconstructive surgery often is limited by the availability of normal tissue. Tissue engineering provides promise in the development of "artificial tissues." The purpose of this study was to test the efficacy and viability of the use of a biologic surgical adhesive TISSEEL in combining engineered br... | ['Biodegradation, Environmental', 'Bronchi', 'Cells, Cultured', 'Chondrocytes', 'Coculture Techniques', 'Fibrin Tissue Adhesive', 'Humans', 'Respiratory Mucosa', 'Surgical Mesh', 'Tissue Adhesives', 'Tissue Engineering', 'Trachea'] | 12,077,766 | [['N06.230.080.600.500', 'N06.850.460.375.500'], ['A04.411.125'], ['A11.251'], ['A11.329.171'], ['E05.481.500.374'], ['D12.776.124.270.305'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A04.760', 'A10.615.550.760'], ['E07.858.708'], ['D25.919', 'D27.720.102.919', 'E07.858.690.860', 'J01.637.051.919'], ['E05.481.... | ['Health Care [N]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
2-Hydroxyestradiol is not mediating the effects of estradiol on tuberoinfundibular dopaminergic neurons controlling prolactin secretion in female rats. | Conversion of estrogens in their hydroxylated derivatives has been proposed as one of the mechanisms of action for these steroids in the brain. However, the actions of catechol estrogens on the hypothalamic control of the prolactin (PRL) release seem to be different to the effects caused by native estrogens. To clarify... | ['3,4-Dihydroxyphenylacetic Acid', 'Animals', 'Dopamine', 'Estradiol', 'Estrogens, Catechol', 'Female', 'Hypothalamus, Middle', 'Neurons', 'Ovariectomy', 'Pituitary Gland, Anterior', 'Progesterone', 'Prolactin', 'Rats', 'Rats, Inbred Strains', 'Reference Values'] | 2,536,446 | [['D02.241.223.601.220'], ['B01.050'], ['D02.092.211.215.406', 'D02.092.311.342', 'D02.455.426.559.389.657.166.175.342'], ['D04.210.500.365.415.248', 'D06.472.334.851.437.500'], ['D02.455.426.559.389.657.166.350', 'D06.472.334.851.437.984'], ['A08.186.211.180.497.352', 'A08.186.211.200.317.357.352'], ['A08.675', 'A11.6... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects on penile reflexes and plasma hormones of hyperprolactinemia induced by MtTW15 tumors. | The effects of severe hyperprolactinemia induced by MtTW15 tumors (prolactin- and growth-hormone-secreting pituitary adenoma) on penile reflex activity and blood hormones were examined. There was no significant adverse effect of hyperprolactinemia on penile reflexes at 7, 14, or 21 days after tumor inoculation. However... | ['Animals', 'Dihydrotestosterone', 'Hyperprolactinemia', 'Male', 'Neoplasm Transplantation', 'Penis', 'Pituitary Neoplasms', 'Progesterone', 'Prolactin', 'Rats', 'Rats, Inbred Strains', 'Reflex, Abnormal', 'Testosterone'] | 4,054,854 | [['B01.050'], ['D04.210.500.054.040.248', 'D06.472.334.851.968.964'], ['C10.228.140.617.738.250.450', 'C19.700.355.600'], ['E05.624'], ['A05.360.444.492'], ['C04.588.322.609', 'C04.588.614.250.195.885.500.600', 'C10.228.140.211.885.500.600', 'C10.228.140.617.477.600', 'C10.228.140.617.738.675', 'C10.551.240.250.700.500... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Transient global amnesia: concomitant episodic memory and positron emission tomography assessment in two additional patients. | Transient global amnesia (TGA) is characterized by a profound but transient deficit of episodic memory. The study of cerebral blood flow and oxygen metabolism with positron emission tomography (PET) provides relevant pathophysiologic data, but only three patients have been reported so far and in only one was concomitan... | ['Aged', 'Amnesia, Transient Global', 'Amygdala', 'Cognition', 'Female', 'Hippocampus', 'Humans', 'Learning', 'Memory', 'Middle Aged', 'Neuropsychological Tests', 'Tomography, Emission-Computed'] | 12,023,067 | [['M01.060.116.100'], ['C10.228.140.060', 'C10.597.606.525.100.800', 'C23.888.592.604.529.100.800', 'F01.700.625.100.800', 'F03.615.200.800'], ['A08.186.211.180.090', 'A08.186.211.200.885.287.249.152'], ['F02.463.188'], ['A08.186.211.180.405', 'A08.186.211.200.885.287.500.345'], ['B01.050.150.900.649.313.988.400.112.40... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Adaptive evolution of malaria parasites in French Guiana: Reversal of chloroquine resistance by acquisition of a mutation in pfcrt. | In regions with high malaria endemicity, the withdrawal of chloroquine (CQ) as first-line treatment of Plasmodium falciparum infections has typically led to the restoration of CQ susceptibility through the reexpansion of the wild-type (WT) allele K76 of the chloroquine resistance transporter gene (pfcrt) at the expense... | ['Alleles', 'Chloroquine', 'Drug Resistance', 'Evolution, Molecular', 'French Guiana', 'Genetic Markers', 'Genome', 'Genotype', 'Haplotypes', 'Humans', 'Inhibitory Concentration 50', 'Malaria', 'Membrane Transport Proteins', 'Mutation', 'Phenotype', 'Plasmodium falciparum', 'Prevalence', 'Principal Component Analysis',... | 26,261,345 | [['G05.360.340.024.340.030'], ['D03.633.100.810.050.180'], ['G07.690.773.984'], ['G05.045.250', 'G16.075.250'], ['Z01.107.757.435'], ['D23.101.387', 'G05.695.450'], ['G05.360.340'], ['G05.380'], ['G05.380.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.940.350', 'G07.690.936.563'], ['C01.610.752.530', 'C0... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Adrenergic stimulation of diacylglycerol production in genital tract smooth muscle myocytes. | Diacylglycerol (DAG) production has not been reported in previous studies that have characterized inositol phosphate production during alpha-1 adrenergic receptor signal transduction in the DDT1 MF-2 genital tract myocytes. The current study sought to measure norepinephrine (NE)-stimulated DAG production in these trans... | ['Animals', 'Cell Line', 'Cricetinae', 'Diglycerides', 'Genitalia, Male', 'Male', 'Mesocricetus', 'Muscle, Smooth', 'Receptors, Adrenergic', 'Sympatholytics', 'Sympathomimetics', 'Testosterone'] | 8,331,032 | [['B01.050'], ['A11.251.210'], ['B01.050.150.900.649.313.992.635.075.250'], ['D10.351.303'], ['A05.360.444'], ['B01.050.150.900.649.313.992.635.075.250.500'], ['A02.633.570', 'A10.690.467'], ['D12.776.543.750.670.300.300', 'D12.776.543.750.695.150.300', 'D12.776.543.750.720.330.300'], ['D27.505.696.663.050.850'], ['D27... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Oxidative damage to plasma constituents by ozone. | The reaction of ozone (O3) with human blood plasma was studied to help understand possible events that could occur in the respiratory tract. Uric acid (quantitatively the most important scavenger) and ascorbic acid were oxidized quickly, protein-SH groups were lost more slowly, and there was no loss of bilirubin or alp... | ['Adult', 'Antioxidants', 'Ascorbic Acid', 'Humans', 'In Vitro Techniques', 'Kinetics', 'Lipid Peroxidation', 'Male', 'Middle Aged', 'Oxidation-Reduction', 'Ozone', 'Uric Acid'] | 1,544,461 | [['M01.060.116'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['D02.241.081.844.107', 'D02.241.511.902.107', 'D09.811.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.481'], ['G01.374.661', 'G02.111.490'], ['G02.111.515', 'G03.295.531.587'], ['M01.060.116.630'], ['G02.700', 'G03.295.531'... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Ten years of snake bites at Fremantle Hospital. | Seventy-six patients (30% children) were admitted to Fremantle Hospital over 10 years with suspected snake bite. Twenty-nine patients were definitely bitten, with 26 bites being witnessed. Of the 13 patients definitely envenomated, 11 had a coagulopathy although seven were asymptomatic; four other patients may have bee... | ['Adolescent', 'Adult', 'Antivenins', 'Child', 'Female', 'Hospitals, Community', 'Hospitals, Teaching', 'Humans', 'Male', 'Snake Bites', 'Western Australia'] | 2,246,987 | [['M01.060.057'], ['M01.060.116'], ['D12.776.124.486.485.114.573.601.138', 'D12.776.124.790.651.114.573.601.138', 'D12.776.377.715.548.114.573.601.138', 'D20.215.401.601.163'], ['M01.060.406'], ['N02.278.421.306'], ['N02.278.020.300', 'N02.278.421.639'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C25.723.127.44... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Anticonvulsant and behavioral effects of GABA(B) receptor positive modulator CGP7930 in immature rats. | Possible anticonvulsant action of GABAB receptor positive allosteric modulator CGP7930 was studied in cortical epileptic afterdischarges (ADs) in rat pups 12, 18, and 25 days old. Afterdischarges were induced by six series of stimulation of sensorimotor cortex, and CGP7930 (20 or 40 mg/kgi.p.) was administered after th... | ['Age Factors', 'Analysis of Variance', 'Animals', 'Animals, Newborn', 'Anticonvulsants', 'Disease Models, Animal', 'Dose-Response Relationship, Drug', 'Electric Stimulation', 'Epilepsy', 'Exploratory Behavior', 'Grooming', 'Male', 'Maze Learning', 'Motor Activity', 'Phenols', 'Psychomotor Performance', 'Rats', 'Rats, ... | 23,708,148 | [['N05.715.350.075', 'N06.850.490.250'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['B01.050'], ['B01.050.050.282'], ['D27.505.954.427.080'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['G07.690.773.875', 'G07.690.936.500'], ['E05.723.402'], ['C10.228.140.490'], ['F01.145.387', 'F01.658.370... | ['Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Evidence for peripherally antinociceptive action of propofol in rats: behavioral and spinal neuronal responses to subcutaneous bee venom. | In the present study, behavioral and in vivo electrophysiological methods were used to examine the peripheral effects of propofol on tonic ongoing pain-related responses produced by subcutaneous bee venom-induced inflammatory pain state. Local administration of 0.5 microg propofol produced significant suppression of th... | ['Analgesics', 'Animals', 'Bee Venoms', 'Behavior, Animal', 'Consciousness', 'Male', 'Nociceptors', 'Pain', 'Posterior Horn Cells', 'Propofol', 'Rats', 'Rats, Sprague-Dawley', 'Stimulation, Chemical'] | 15,862,538 | [['D27.505.696.663.850.014', 'D27.505.954.427.040'], ['B01.050'], ['D20.888.065.115', 'D23.946.833.065.115'], ['F01.145.113'], ['F02.463.188.409', 'F02.830.233'], ['A08.675.650.915.875', 'A08.800.950.875', 'A11.671.650.915.875'], ['C23.888.592.612', 'F02.830.816.444', 'G11.561.790.444'], ['A08.186.854.697.500', 'A08.67... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Kinetics of etoposide cytotoxicity against mouse P388 leukemia]. | The in vitro cytotoxicity of etoposide against mouse P388 leukemia cells was kinetically studied and compared with those of podophyllotoxin, the parent compound, and other antitumor agents. When P388 cells were exposed to etoposide, surviving-cell fraction decreased with etoposide concentration and exposure time. Simil... | ['Animals', 'Bleomycin', 'Cell Cycle', 'Cell Survival', 'Cisplatin', 'Colony-Forming Units Assay', 'Cytarabine', 'Doxorubicin', 'Etoposide', 'Fluorouracil', 'Leukemia P388', 'Leukemia, Experimental', 'Melphalan', 'Mice', 'Peplomycin', 'Podophyllotoxin', 'Tumor Stem Cell Assay', 'Vinblastine'] | 2,415,068 | [['B01.050'], ['D09.400.420.110', 'D12.644.233.110'], ['G04.144'], ['G04.346'], ['D01.210.375', 'D01.625.125', 'D01.710.100'], ['E01.370.225.500.383', 'E05.200.500.383', 'E05.242.383'], ['D03.383.742.680.245.453', 'D13.570.065.300', 'D13.570.685.245.453'], ['D02.455.426.559.847.562.050.200.175', 'D04.615.562.050.200.17... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Post-tonsillectomy haemorrhage: reusable and disposable instruments compared. | The aim of this study was to determine if the introduction of disposable instruments for tonsillectomy resulted in a significant change in post-tonsillectomy haemorrhage rates. This is a prospective comparative study of haemorrhage rates for cold dissection (CD) tonsillectomy in adults using reusable instruments during... | ['Adolescent', 'Adult', 'Age Distribution', 'Child', 'Child, Preschool', 'Confidence Intervals', 'Disposable Equipment', 'Equipment Reuse', 'Female', 'Follow-Up Studies', 'Humans', 'Incidence', 'Length of Stay', 'Male', 'Postoperative Hemorrhage', 'Probability', 'Prospective Studies', 'Risk Assessment', 'Sex Distributi... | 12,898,140 | [['M01.060.057'], ['M01.060.116'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['M01.060.406'], ['M01.060.406.448'], ['E05.318.740.275', 'N05.715.360.750.220', 'N06.850.520.830.275'], ['E07.252'], ['E05.328', 'N06.850.585'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Technical aspects of hepatic portal dissection in biliary atresia. | During the past 8 yr, 37 patients with a noncorrectable type of biliary atresia have undergone hepatic portoenterostomy or portocholecystostomy at the Kobe Children's Hospital. The hepatic portal dissections employed in this series were classified as "supraportal" (9 procedures), "portal" (25 procedures), and "infra-po... | ['Bile', 'Biliary Tract', 'Biliary Tract Surgical Procedures', 'Child', 'Humans', 'Liver', 'Methods'] | 106,101 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Helicobacter pylori DNA in recurrent aphthous stomatitis. | BACKGROUND: Considering not only the fact that recurrent aphthous stomatitis (RAS) and stomach ulcers are immunologically mediated ulcers associated with Helicobacter pylori, but also the recent evidence that anaemia can be associated with both diseases, and the discovery of H. pylori in the oral mucosa led us to hypot... | ['Adolescent', 'Adult', 'Aged', 'Chi-Square Distribution', 'Child', 'DNA, Bacterial', 'Helicobacter Infections', 'Helicobacter pylori', 'Humans', 'Middle Aged', 'Mouth Mucosa', 'Recurrence', 'Sequence Analysis, DNA', 'Stomatitis, Aphthous'] | 12,653,861 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['M01.060.406'], ['D13.444.308.212'], ['C01.150.252.400.466'], ['B03.440.500.550', 'B03.660.150.235.500.250.550'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Reduced frequency of murine cytomegalovirus retinitis in C57BL/6 mice correlates with low levels of suppressor of cytokine signaling (SOCS)1 and SOCS3 expression within the eye during corticosteroid-induced immunosuppression. | AIDS-related human cytomegalovirus retinitis remains a leading cause of blindness worldwide. We compared two C57BL/6 mouse models of experimental murine cytomegalovirus (MCMV) retinitis for intraocular expression of suppressors of cytokine signaling (SOCS)1 and SOCS3, host proteins that are inducible negative feedback ... | ['Adrenal Cortex Hormones', 'Animals', 'Cytomegalovirus Retinitis', 'Disease Models, Animal', 'Disease Progression', 'Eye', 'Immune Tolerance', 'Mice', 'Mice, Inbred C57BL', 'Murine Acquired Immunodeficiency Syndrome', 'Muromegalovirus', 'Suppressor of Cytokine Signaling 1 Protein', 'Suppressor of Cytokine Signaling 3 ... | 28,558,309 | [['D06.472.040'], ['B01.050'], ['C01.375.725.270', 'C01.925.256.466.245.150', 'C01.925.325.270', 'C11.294.800.270', 'C11.768.773.360'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['C23.550.291.656'], ['A01.456.505.420', 'A09.371'], ['G12.535.425'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Echinacoside elicits endothelium-dependent relaxation in rat aortic rings via an NO-cGMP pathway. | The aim of this study was to identify and elucidate the vasorelaxant activity of echinacoside, a phenylethanoid glycoside isolated from the medicinal herb Cistanche tubulosa, and its possible underlying mechanism on isolated rat thoracic aortic rings pre-contracted with phenylephrine (PE, 1 microM) and KCl (60 mM). Ech... | ['Animals', 'Aorta, Thoracic', 'Atropine', 'Cistanche', 'Cyclic GMP', 'Endothelium, Vascular', 'Enzyme Inhibitors', 'Glycosides', 'Guanylate Cyclase', 'Male', 'Muscle Relaxation', 'Muscle, Smooth, Vascular', 'Nitric Oxide', 'Phenylephrine', 'Plant Extracts', 'Plant Stems', 'Rats', 'Rats, Sprague-Dawley', 'Receptors, Mu... | 19,468,974 | [['B01.050'], ['A07.015.114.056.372'], ['D02.145.074.722.229.199', 'D03.132.760.180.572.199', 'D03.132.889.180.648.199', 'D03.605.084.500.722.229.199', 'D03.605.869.229.199'], ['B01.650.940.800.575.912.250.583.670.175'], ['D03.633.100.759.646.454.160', 'D13.695.462.275', 'D13.695.667.454.160', 'D13.695.827.426.160'], [... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Lease or buy: optimizing capital equipment procurement. | Many physician group practices struggle over whether to buy or lease equipment. While purchasing has been the traditional method of acquiring equipment, leasing often can be more cost-effective. Conducting a lease-versus-purchase analysis can help group practices arrive at the most cost-effective decision. Careful cons... | ['Accounting', 'Capital Expenditures', 'Decision Making, Organizational', 'Financial Management', 'Group Practice', 'Leasing, Property', 'Organizational Objectives', 'United States'] | 10,168,711 | [['N03.219.463.030'], ['N03.219.151.450.200'], ['N04.452.190'], ['N03.219.463'], ['N04.452.758.244'], ['N03.219.463.500'], ['N04.452.615'], ['Z01.107.567.875']] | ['Health Care [N]', 'Geographicals [Z]'] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Behavioral characteristics in 18- to 36-month-old toddlers with atopic dermatitis compared with healthy children. | Some differences in behavioral characteristics have been attributed to atopic dermatitis (AD). In this study, AD patients compared with healthy toddlers had significantly higher scores in perceptual sensitivity and high pleasure in an early childhood behavior questionnaire (ECBQ). They tended to be more energetic and i... | ['Child Behavior', 'Child, Preschool', 'Dermatitis, Atopic', 'Exploratory Behavior', 'Female', 'Humans', 'Impulsive Behavior', 'Infant', 'Infant Behavior', 'Male', 'Perception', 'Pleasure', 'Severity of Illness Index', 'Surveys and Questionnaires'] | 20,609,162 | [['F01.145.179'], ['M01.060.406.448'], ['C16.320.850.210', 'C17.800.174.193', 'C17.800.815.193', 'C17.800.827.210', 'C20.543.480.343'], ['F01.145.387', 'F01.658.370'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.527'], ['M01.060.703'], ['F01.145.179.500'], ['F02.463.593'], ['F01.470.867', 'F02.830.816.49... | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Evaluation of a non-name-based HIV reporting system in San Francisco. | OBJECTIVE: To develop and evaluate a non-name-based HIV reporting system.METHODS: A population-based study of the accuracy of a set of non-name codes and a prospective study of a laboratory-initiated HIV surveillance system conducted at a county hospital (site 1) and a health maintenance organization (site 2). Particip... | ['Disease Notification', 'Female', 'HIV Infections', 'Health Maintenance Organizations', 'Hospitals, County', 'Humans', 'Male', 'Population Surveillance', 'Registries', 'San Francisco'] | 11,981,367 | [['E05.318.362', 'N06.850.520.373', 'N06.850.780.200.262'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['N03.219.521.576.343.800.400', 'N03.219.521.576.343.925.400', 'N04.452.758.244.425', 'N04.590.374.410.400'], ['N02.278.421.510.100'], [... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Benefits of carbon dioxide as pH reducer in chlorinated indoor swimming pools. | Carbon dioxide is seldom used as pH reducer in swimming pools. Nevertheless it offers two interesting advantages. First, its use instead of the usual hydrochloric acid avoids the characteristic and serious accident of mixing the disinfectant with that strong acid, which forms a dangerous chlorine gas cloud and, second,... | ['Carbon Dioxide', 'Chlorine', 'Colorimetry', 'Hydrogen-Ion Concentration', 'Swimming Pools', 'Trihalomethanes'] | 20,529,696 | [['D01.200.200', 'D01.362.150', 'D01.650.550.200'], ['D01.268.380.150', 'D01.362.225'], ['E05.196.922.250'], ['G02.300'], ['J03.925.830'], ['D02.455.526.913']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Interleukin-2-inducible T cell kinase (Itk) network edge dependence for the maturation of iNKT cell. | Invariant natural killer T (iNKT) cells are a unique subset of innate T lymphocytes that are selected by CD1d. They have diverse immune regulatory functions via the rapid production of interferon-ã (IFN-ã) and interleukin-4 (IL-4). In the absence of signaling nodes Itk and Txk, Tec family non-receptor tyrosine kinases,... | ['Animals', 'Cell Count', 'Cytokines', 'Gene Expression Regulation', 'Interleukin-2 Receptor beta Subunit', 'Mice', 'Natural Killer T-Cells', 'Protein Structure, Tertiary', 'Protein-Tyrosine Kinases', 'T-Box Domain Proteins', 'Thymus Gland'] | 21,036,902 | [['B01.050'], ['E01.370.225.500.195', 'E05.200.500.195', 'E05.242.195', 'G04.140'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['G05.308'], ['D12.776.543.750.705.852.420.320.750', 'D12.776.543.750.705.852.420.800.500'], ['B01.050.150.900.649.313.992.635.505.500'], ['A11.118.637.555.567.569.290', 'A15.145.22... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Prostaglandin E2 is activated by airway injury and regulates fibroblast cytoskeletal dynamics. | OBJECTIVES/HYPOTHESIS: To characterize the activation of cyclooxygenase (COX)-2/prostaglandin (PG) E2 signaling during airway mucosal repair and its subsequent role during the wound healing process.STUDY DESIGN: Prospective animal study.METHODS: The subglottis was approached via cricothyroidotomy. Sham airways were clo... | ['Animals', 'Cell Culture Techniques', 'Cell Movement', 'Cyclooxygenase 2', 'Cyclooxygenase Inhibitors', 'Dinoprostone', 'Enzyme-Linked Immunosorbent Assay', 'Fibroblasts', 'Interleukin-1', 'Lasers', 'Prospective Studies', 'Rabbits', 'Reverse Transcriptase Polymerase Chain Reaction', 'Signal Transduction', 'Trachea', '... | 19,444,894 | [['B01.050'], ['E01.370.225.500.223', 'E05.200.500.265', 'E05.242.223', 'E05.481.500.249'], ['G04.198', 'G07.568.500.180'], ['D08.811.600.720.750'], ['D27.505.519.389.310', 'D27.505.696.663.850.014.040.500.500', 'D27.505.954.158.030.500', 'D27.505.954.329.030.500'], ['D10.251.355.255.550.250.200', 'D23.469.050.175.725.... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[The effect of antioxidant therapy on indicators of activity of free radicals in workers exposed to risks of styrene]. | To 30 workers exposed to the risk of styrene for a period of 30 days a mixture of antioxidants was administered: vitamin C 200 mg, vitamin E 300 mg, selenium 20 mg, troxerutin 600 mg and beta-carotene 6 mg. Before the onset of supplementation and immediately afterwards laboratory indicators of antioxidant protection an... | ['Adult', 'Aged', 'Antioxidants', 'Female', 'Free Radicals', 'Glutathione Peroxidase', 'Humans', 'Male', 'Malondialdehyde', 'Middle Aged', 'Occupational Exposure', 'Risk Factors', 'Styrene', 'Styrenes', 'Superoxide Dismutase'] | 9,601,870 | [['M01.060.116'], ['M01.060.116.100'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['D01.339', 'D02.389'], ['D08.811.682.732.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.047.700'], ['M01.060.116.630'], ['N06.850.460.350.600'], ['E05.318.740.600.800.725', 'N05.715.350.200.700', 'N05.7... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Automated gastric slow wave cycle partitioning and visualization for high-resolution activation time maps. | High-resolution (HR) multi-electrode mapping has become an important technique for evaluating gastrointestinal (GI) slow wave (SW) behaviors. However, the application and uptake of HR mapping has been constrained by the complex and laborious task of analyzing the large volumes of retrieved data. Recently, a rapid and r... | ['Algorithms', 'Animals', 'Diagnosis, Computer-Assisted', 'Electromyography', 'Myoelectric Complex, Migrating', 'Pattern Recognition, Automated', 'Reproducibility of Results', 'Sensitivity and Specificity', 'Swine'] | 20,927,594 | [['G17.035', 'L01.224.050'], ['B01.050'], ['E01.158', 'L01.313.500.750.100.158'], ['E01.370.405.255', 'E01.370.530.255'], ['G07.265.675.775', 'G10.261.360.570', 'G11.427.494.730', 'G11.561.570.837'], ['L01.399.750'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['E05.318.370.800', '... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Results from a patient survey to assess gastrointestinal burden of non-steroidal anti-inflammatory drug therapy contrasted with a review of data from EVA to determine satisfaction with rofecoxib. | Non-steroidal anti-inflammatory drugs (NSAIDs) have frequently been linked with unpleasant gastrointestinal (GI) side-effects such as dyspepsia and ulcers. The present study investigated the burden of NSAID therapy from a patient perspective and also reviewed previously published data on satisfaction with a less gastro... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Anti-Inflammatory Agents, Non-Steroidal', 'Child', 'Cost of Illness', 'Cyclooxygenase Inhibitors', 'Drug Therapy, Combination', 'Gastrointestinal Diseases', 'Health Surveys', 'Humans', 'Lactones', 'Middle Aged', 'Osteoarthritis', 'Patient Satisfaction', 'Quality of ... | 12,173,277 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.696.663.850.014.040.500', 'D27.505.954.158.030', 'D27.505.954.329.030'], ['M01.060.406'], ['N03.219.151.165', 'N05.715.360.300.800.438.375.182', 'N06.850.520.308.980.438.475.046'], ['D27.505.519.389.310', 'D27.505.696.663.850.014... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Developmental expression of beta-catenin in mouse retina. | Recent studies have shown that catenins play a pivotal role in neuronal signalling during vertebrate development. In order to study the significance of beta-catenin in the developing mouse retina, the localization of beta-catenin was examined by immunohistochemistry from embryonic day (E) 12 to adult mice. Immunoreacti... | ['Aging', 'Animals', 'Animals, Newborn', 'Cell Differentiation', 'Cytoskeletal Proteins', 'Down-Regulation', 'Female', 'Fetus', 'Gene Expression Regulation, Developmental', 'Immunohistochemistry', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Neurons', 'Pigment Epithelium of Eye', 'RNA, Messenger', 'Retina', 'Retinal Ganglion... | 12,422,411 | [['G07.345.124'], ['B01.050'], ['B01.050.050.282'], ['G04.152'], ['D12.776.220'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['A16.378'], ['G05.308.310'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512', 'H01.158.201.3... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
JNK1â1 is phosphorylated during expression in E. coli and in vitro by MKK4 at three identical novel sites. | JNK1 is activated by phosphorylation of the canonical T183 and Y185 residues, modifications that are catalysed typically by the upstream eukaryotic kinases MKK4 and MKK7. Nonetheless, the exact sites at which the most abundant JNK variant, JNK1â1, is further modified by MKK4 for phospho-regulation has not been previous... | ['Escherichia coli', 'Humans', 'MAP Kinase Kinase 4', 'Mass Spectrometry', 'Mitogen-Activated Protein Kinase 8', 'Phosphorylation', 'Protein Processing, Post-Translational', 'Protein Structure, Secondary', 'Protein Structure, Tertiary', 'Recombinant Proteins'] | 23,416,355 | [['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.913.696.620.682.700.565.400', 'D08.811.913.696.620.682.725.200.400', 'D12.644.360.440.400', 'D12.776.476.440.400'], ['E05.196.566'], ['D08.811.913.696.620.682.700.567.374.500', 'D12.644.360.450.340.500', ... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Calcium-channel blockers and sodium intake: a controlled study in patients with essential hypertension. | Thirteen patients with mild to moderate essential hypertension and whose average supine blood pressure with no treatment was 165/104 mmHg were studied as inpatients for 3 consecutive one-week periods on different sodium intakes. On the last day of each dietary period, they received a single, 20-mg nitrendipine tablet a... | ['Adult', 'Blood Pressure', 'Body Weight', 'Calcium Channel Blockers', 'Female', 'Humans', 'Hypertension', 'Male', 'Middle Aged', 'Nitrendipine', 'Pulse', 'Sodium', 'Sodium, Dietary'] | 2,487,528 | [['M01.060.116'], ['E01.370.600.875.249', 'G09.330.380.076'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['D27.505.519.562.249', 'D27.505.696.260.500', 'D27.505.954.411.192'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['M0... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
P-31 nuclear magnetic resonance analysis of brain: II. Effects of oxygen deprivation on isolated perfused and nonperfused rat brain. | Phosphatic metabolite (perchloric acid extractable) concentrations of cerebral tissues were analyzed by phosphorus-31 nuclear magnetic resonance (P-31 NMR) spectroscopy following external perfusion of the isolated rat brain (30 min or 60 min) under the following conditions: (a) constant perfusion pressure with either f... | ['Animals', 'Brain', 'Brain Ischemia', 'Electroencephalography', 'Energy Metabolism', 'Erythrocytes', 'Fluorocarbons', 'Hypoxia', 'In Vitro Techniques', 'Magnetic Resonance Spectroscopy', 'Male', 'Nucleotides', 'Perchlorates', 'Perfusion', 'Phosphates', 'Phosphocreatine', 'Rats', 'Rats, Inbred Strains', 'Sugar Phosphat... | 6,092,545 | [['B01.050'], ['A08.186.211'], ['C10.228.140.300.150', 'C14.907.253.092'], ['E01.370.376.300', 'E01.370.405.245'], ['G03.295'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['D02.455.526.510.435'], ['C23.888.852.079'], ['E05.481'], ['E05.196.867.519'], ['D09.408.620', 'D13.695'], ['D01.029.260.650', 'D01.210.675'... | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Relational supervision: drawing on cognitive-analytic frameworks. | PURPOSE: Supervision is an expanding area of clinical practice, and despite the threadbare evidence base, the demand for supervision provided by trained clinical supervisors is growing. This demand accompanies the injection of large numbers of psychological therapists into the UK National Health Service (NHS), and the ... | ['Adult', 'Child', 'Clinical Competence', 'Clinical Governance', 'Cognitive Behavioral Therapy', 'Cooperative Behavior', 'Female', 'Humans', 'Interprofessional Relations', 'Male', 'Models, Psychological', 'Organizational Culture', 'Personal Construct Theory', 'Personality Development', 'Psychotherapeutic Processes', 'S... | 22,903,883 | [['M01.060.116'], ['M01.060.406'], ['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['N04.452.115'], ['F04.754.137.350'], ['F01.145.813.115'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.401.205'], ['E05.599.695'], ['N04.452.606'], ['F02.739.660'], ['F01.752.747'], ['F04.754.720'], ['F01.752.747.792'],... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Determination of DNA and RNA Methylation in Circulating Tumor Cells by Mass Spectrometry. | DNA methylation (5-methylcytosine, 5-mC) is the best characterized epigenetic mark that has regulatory roles in diverse biological processes. Recent investigation of RNA modifications also raises the possible functions of RNA adenine and cytosine methylations on gene regulation in the form of "RNA epigenetics." Previou... | ['Chromatography, High Pressure Liquid', 'DNA Methylation', 'DNA, Neoplasm', 'Humans', 'Lung Neoplasms', 'MCF-7 Cells', 'Neoplastic Cells, Circulating', 'RNA, Neoplasm', 'Tandem Mass Spectrometry'] | 26,707,930 | [['E05.196.181.400.300'], ['G02.111.035.538.161', 'G02.111.218', 'G03.059.538.161', 'G05.206'], ['D13.444.308.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['A11.251.210.190.630'], ['A11.642', 'C04.697.650.900', 'C23.550.727.650.900'], ['D13.444.735.615']... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Pituitary Cushing's syndrome and Nelson's syndrome: diagnostic criteria, surgical therapy, and results. | Eight patients with pituitary Cushing's syndrome and 2 with Nelson's syndrome were followed from one to ten years after removal of pituitary adenomas. A detailed assessment of the pituitary-adrenal axis was obtained in all patients when last seen, save the first, who had undergone a complete hypophysectomy ten years pr... | ['Adrenocorticotropic Hormone', 'Adult', 'Cushing Syndrome', 'Dexamethasone', 'Diagnosis, Differential', 'Female', 'Humans', 'Hydrocortisone', 'Male', 'Middle Aged', 'Nelson Syndrome', 'Pituitary Neoplasms'] | 6,278,664 | [['D06.472.699.327.935.531.500', 'D06.472.699.631.525.600.531.500', 'D12.644.400.400.935.531.500', 'D12.644.548.365.935.531.500', 'D12.644.548.691.525.690.531.500', 'D12.776.631.650.405.935.531.500'], ['M01.060.116'], ['C19.053.800.367'], ['D04.210.500.745.432.769.344', 'D04.210.500.908.238'], ['E01.171'], ['B01.050.15... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Stoichiometry and stability of the adduct formed between human 4-aminobutyrate aminotransferase and 4-aminohex-5-enoate: sequence of a labelled peptide. | The reaction between human 4-aminobutyrate aminotransferase and the anti-epileptic drug 4-aminohex-5-enoate, an irreversible inhibitor of the enzyme, has been studied using the radiolabelled compound. The inactivated enzyme was found to lose radiolabel over a period of a few days at 37 degrees C but even in the presenc... | ['4-Aminobutyrate Transaminase', 'Amino Acid Sequence', 'Aminocaproates', 'Binding Sites', 'Chromatography, High Pressure Liquid', 'Enzyme Stability', 'Molecular Sequence Data', 'Protein Binding', 'Vigabatrin'] | 2,503,053 | [['D08.811.913.477.700.200'], ['G02.111.570.060', 'L01.453.245.667.060'], ['D02.241.081.193.150', 'D12.125.213'], ['G02.111.570.120'], ['E05.196.181.400.300'], ['E05.916.360', 'G02.111.700.500'], ['L01.453.245.667'], ['G02.111.679', 'G03.808'], ['D02.241.081.114.500.350.900', 'D12.125.190.350.900']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Influence of particle size on the effectiveness of beet pulp fiber. | Sixteen Holstein cows in midlactation were used in a design based on a replicated 4 x 4 Latin square with the last period removed to determine the influence of particle size of beet pulp neutral detergent fiber (NDF) on its effectiveness as a replacement for alfalfa NDF. Diets were a low forage, low fiber diet [12.1 g ... | ['Animal Nutritional Physiological Phenomena', 'Animals', 'Cattle', 'Dietary Fiber', 'Digestion', 'Eating', 'Female', 'Lactation', 'Lipids', 'Medicago sativa', 'Milk', 'Milk Proteins', 'Particle Size', 'Vegetables'] | 9,178,130 | [['G07.203.650.161'], ['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['D09.301.416', 'G07.203.300.400', 'J02.500.400'], ['G07.203.650.250', 'G10.261.190'], ['G07.203.650.283', 'G10.261.330'], ['G08.686.523', 'G08.686.702.500'], ['D10'], ['B01.650.940.800.575.912.250.401.590.500'], ['A12.200.455', 'A12.790', 'G07... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Teaching & Learning Tips 4: Motivation and emotion in learning. | Challenge: Trainees' motivational and emotional states can influence their learning and career decisions, but historically these "affective" learning factors have received little attention in medical education. In this "Tips" piece, we outline strategies to positively influence trainees' intrinsic motivation and emotio... | ['Dermatology', 'Emotions', 'Humans', 'Learning', 'Motivation', 'Personal Autonomy', 'Psychological Theory', 'Self Efficacy', 'Teaching'] | 29,330,931 | [['H02.403.225'], ['F01.470'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.425', 'F02.784.629.529'], ['F01.658', 'F01.752.543.500.750'], ['F02.600', 'I01.880.604.473.380.500', 'K01.752.566.479.830.650', 'N03.706.437.380.500', 'N05.350.958.650'], ['F02.739'], ['F01.752.747.792.700'], ['I02.903']] | ['Disciplines and Occupations [H]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 |
Structure-function analysis of tritrypticin, an antibacterial peptide of innate immune origin. | The structural requirements for the antibacterial activity of a pseudosymmetric 13-residue peptide, tritrypticin, were analyzed by combining pattern recognition in protein structures, the structure-activity knowledge-base, and circular dichroism. The structure-activity analysis, based on various deletion analogs, led t... | ['Amino Acid Sequence', 'Anti-Bacterial Agents', 'Bone Marrow', 'Circular Dichroism', 'Escherichia coli', 'Models, Molecular', 'Peptides', 'Proteins', 'Salmonella typhimurium', 'Structure-Activity Relationship'] | 10,438,505 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D27.505.954.122.085'], ['A15.382.216'], ['E05.196.867.151'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['E05.599.595'], ['D12.644'], ['D12.776'], ['B03.440.450.425.800.200.825', 'B03.660.250.150.710.160.760'], ['G02.111.830', 'G07.690.773.997']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Phosphoproteome profiling for cold temperature perception. | Temperature sensation initiates from the activation of cellular receptors when the cell is exposed to a decrease in temperature. Here, we applied a phosphoproteome profiling approach to the human lung epithelial cell line BEAS-2B to elucidate cellular cold-responsive processes. The primary aim of this study was to dete... | ['Blotting, Western', 'Cell Line', 'Cold Temperature', 'Electrophoresis, Gel, Two-Dimensional', 'Humans', 'Immunohistochemistry', 'Immunoprecipitation', 'Phosphoproteins', 'RNA-Binding Proteins', 'Tandem Mass Spectrometry'] | 21,268,085 | [['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['A11.251.210'], ['G01.906.595.272', 'G16.500.275.063.725.710.300', 'G16.500.750.775.710.300', 'N06.230.300.100.725.154', 'N06.230.300.100.725.710.300'], ['E05.196.401.250', 'E05.301.300.230'], ['B01.050.150.900.649.31... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Autotransplantation of transmigrated mandibular canine. | Transplantation is the transfer of tissue or an organ from one site to another in the same person or between different persons. A transplantation in which donor and recipient are the same individual has been termed as autogenous transplantation, autoplastic transplantation, or autotransplantation. The purpose of this r... | ['Child', 'Dental Arch', 'Female', 'Humans', 'Mandible', 'Prognosis', 'Radiography', 'Tooth, Impacted', 'Transplantation, Autologous'] | 19,213,383 | [['M01.060.406'], ['A02.835.232.781.324.502.320', 'A14.521.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.232.781.324.502.632', 'A14.521.632'], ['E01.789'], ['E01.370.350.700'], ['C07.793.905'], ['E04.936.664']] | ['Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Blood pressure response, but not adverse event incidence, correlates with dose of angiotensin II antagonist. | OBJECTIVE: To assess the efficacy and safety of the novel angiotensin II antagonist olmesartan medoxomil in patients with mild to moderate essential hypertension, using a meta-analysis of the combined database from seven US and European clinical trials.DESIGN: Studies were randomized, double-blind, placebo-controlled a... | ['Angiotensin II', 'Antihypertensive Agents', 'Blood Pressure', 'Dose-Response Relationship, Drug', 'Humans', 'Imidazoles', 'Incidence', 'Olmesartan Medoxomil', 'Randomized Controlled Trials as Topic', 'Safety', 'Tetrazoles'] | 11,451,214 | [['D06.472.699.094.078', 'D12.644.400.070.078', 'D12.644.456.073.041', 'D12.644.548.058.078', 'D12.776.631.650.070.078', 'D23.469.050.050.050'], ['D27.505.954.411.162'], ['E01.370.600.875.249', 'G09.330.380.076'], ['G07.690.773.875', 'G07.690.936.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.383.129.308... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
A chimeric EBV gp350/220-based VLP replicates the virion B-cell attachment mechanism and elicits long-lasting neutralizing antibodies in mice. | Epstein-Barr virus (EBV), an oncogenic gammaherpesvirus, causes acute infectious mononucleosis (AIM) and is linked to the development of several human malignancies. There is an urgent need for a vaccine that is safe, prevents infection and/or limits disease. Unique among human herpesviruses, glycoprotein (gp)350/220, w... | ['Animals', 'Antibodies, Neutralizing', 'Antigens, CD', 'B-Lymphocytes', 'Cell Adhesion', 'Cell Line', 'Humans', 'Immunization', 'Immunoglobulin G', 'Mice, Inbred BALB C', 'Neutralization Tests', 'Protein Binding', 'Recombinant Proteins', 'Viral Matrix Proteins', 'Virion'] | 25,885,535 | [['B01.050'], ['D12.776.124.486.485.114.244', 'D12.776.124.790.651.114.244', 'D12.776.377.715.548.114.244'], ['D23.050.301.264.035', 'D23.101.100.110'], ['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['G04.022'], ['A11.251.210'], ['B01.050.150.90... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
CEACAM6 as a novel target for indirect type 1 immunotoxin-based therapy in pancreatic adenocarcinoma. | Immunotoxins are a potentially powerful approach for targeted anticancer therapy. We evaluated a novel immunotherapeutic strategy targeting the immunoglobulin superfamily member carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6). Using pancreatic adenocarcinoma as a model, we show that crosslinking CEA... | ['Adenocarcinoma', 'Antigens, CD', 'Antigens, Neoplasm', 'Caspase 3', 'Caspases', 'Cell Adhesion Molecules', 'Cell Line, Tumor', 'GPI-Linked Proteins', 'Humans', 'Pancreatic Neoplasms'] | 15,081,416 | [['C04.557.470.200.025'], ['D23.050.301.264.035', 'D23.101.100.110'], ['D23.050.285'], ['D08.811.277.656.262.500.126.350.300', 'D08.811.277.656.300.200.126.350.300', 'D12.644.360.075.405.350.300', 'D12.776.476.075.405.350.300'], ['D08.811.277.656.262.500.126', 'D08.811.277.656.300.200.126', 'D12.644.360.075.405', 'D12.... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Randomized Controlled Trial of an Internet-Based Educational Intervention for Mothers With Mental Illnesses: An 18-Month Follow-Up. | OBJECTIVE: A randomized controlled trial was conducted to examine the effectiveness of an Internet-based educational intervention plus a peer support-moderated listserv for improving parenting skills and coping and reducing parental stress among mothers with serious mental illnesses. The analyses examined whether posit... | ['Adaptation, Psychological', 'Adult', 'Female', 'Follow-Up Studies', 'Humans', 'Internet', 'Mental Disorders', 'Mothers', 'Parenting', 'Patient Education as Topic', 'Stress, Psychological'] | 31,023,190 | [['F01.058'], ['M01.060.116'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.230.110.500'], ['F03'], ['F01.829.263.500.320.200', 'I01.880.853.150.500.340.270', 'M01.620.630'], ['F01.829.263.370.310'], ['I02.233.332.5... | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Information Science [L]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 0 |
Degradation of Insecticides in Poultry Manure: Determining the Insecticidal Treatment Interval for Managing House Fly (Diptera: Muscidae) Populations in Poultry Farms. | It is crucial to understand the degradation pattern of insecticides when designing a sustainable control program for the house fly, Musca domestica (L.), on poultry farms. The aim of this study was to determine the half-life and degradation rates of cyromazine, chlorpyrifos, and cypermethrin by spiking these insecticid... | ['Animals', 'Houseflies', 'Insect Control', 'Insecticides', 'Manure', 'Pesticide Residues', 'Poultry'] | 26,896,536 | [['B01.050'], ['B01.050.500.131.617.720.500.500.750.642.470'], ['N06.850.780.200.650.425'], ['D27.720.031.700.491', 'D27.888.723.491'], ['D20.601'], ['D27.720.031.700.672', 'D27.888.723.697', 'N06.850.460.200.700'], ['B01.050.050.116.625', 'B01.050.150.900.248.690', 'G07.203.300.600.750', 'J02.500.600.750']] | ['Organisms [B]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Profound ionized hypomagnesemia induced by therapeutic plasma exchange in liver failure patients. | BACKGROUND: Various adverse effects, including cardiac arrest, have been induced by plasma exchange (PE). Electrolyte derangement is frequently observed. The purpose of this study was to assess the effect of PE on the serum ionized magnesium (Mg2+) concentration in acute liver failure patients.STUDY DESIGN AND METHODS:... | ['Acid-Base Equilibrium', 'Adult', 'Aged', 'Calcium', 'Female', 'Hematocrit', 'Humans', 'Ion-Selective Electrodes', 'Liver Failure', 'Magnesium', 'Magnesium Deficiency', 'Male', 'Middle Aged', 'Plasma Exchange', 'Time Factors', 'Water-Electrolyte Imbalance'] | 12,473,141 | [['G02.111.007', 'G02.300.176', 'G03.030', 'G07.410.110', 'G09.188.050'], ['M01.060.116'], ['M01.060.116.100'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['E01.370.225.625.400', 'E05.200.625.400', 'G09.188.370.374'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E07.305.250.471'], ['C06.552.308.500'],... | ['Phenomena and Processes [G]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
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