Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Extra-articular dorsal closing-wedge osteotomy to treat late-stage Freiberg disease using polyblend sutures: technical tips and clinical results. | PURPOSE: The purpose of this study was to evaluate the clinical outcomes regarding the dorsal wedge osteotomy fixed using a polyblend suture and describe the usefulness of this fixation method for the treatment of Freiberg disease.METHODS: The subjects consisted of 13 feet from 13 cases suffering from Freiberg disease ... | ['Adolescent', 'Adult', 'Aged', 'Female', 'Humans', 'Male', 'Metatarsus', 'Middle Aged', 'Osteochondritis', 'Osteotomy', 'Sutures', 'Young Adult'] | 24,867,357 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A01.378.610.250.300.480'], ['M01.060.116.630'], ['C05.116.791', 'C05.182.520', 'C17.300.182.520'], ['E04.555.580'], ['E07.858.690.820'], ['M01.060.116.815']] | ['Named Groups [M]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Unusual variants of infantile spasms. | During evaluation of video-electroencephalograms (EEGs) performed in our laboratory, we identified 11 patients who had unusual repetitive movements that appeared to be variants of infantile spasms. Movements included yawning, facial grimacing, eye movements, and transient focal motor activity. These symptoms coincided ... | ['Cerebral Cortex', 'Diagnosis, Differential', 'Electroencephalography', 'Evoked Potentials', 'Female', 'Follow-Up Studies', 'Humans', 'Infant', 'Male', 'Monitoring, Physiologic', 'Muscle Contraction', 'Spasms, Infantile', 'Telemetry', 'Video Recording'] | 1,940,132 | [['A08.186.211.200.885.287.500'], ['E01.171'], ['E01.370.376.300', 'E01.370.405.245'], ['G07.265.216.500', 'G11.561.200.500'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['E01.370.520'], ['G11.427.494'], ['... | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]', 'Diseases [C]', 'Information Science [L]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Highly prevalent and poorly controlled cardiovascular risk factors among Chinese elderly people living in the rural community. | BACKGROUND: The epidemiological scenario of cardiovascular risk factors (CRFs) among elderly people in rural China is unclear. We seek to describe the distribution, burden and management of major CRFs among older Chinese people living in the rural community.METHODS: This cross-sectional study included 1538 participants... | ['Age Factors', 'Aged', 'Aged, 80 and over', 'Aging', 'Asian Continental Ancestry Group', 'Cardiovascular Diseases', 'China', 'Cross-Sectional Studies', 'Female', 'Health Care Surveys', 'Health Status Disparities', 'Humans', 'Independent Living', 'Life Style', 'Male', 'Middle Aged', 'Prevalence', 'Prognosis', 'Risk Fac... | 23,598,595 | [['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['G07.345.124'], ['M01.686.508.200'], ['C14'], ['Z01.252.474.164'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['E05.318.308.980.344', 'N03.349.380.210', 'N05.425.210', 'N05.715.360.300.800.344', '... | ['Health Care [N]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Deaths due to foreign body aspiration in children: the continuing hazard of toy balloons. | Asphyxia due to aspiration of a foreign body is a common cause of accidental death in children. Foreign body aspiration is the most likely cause of accidental fatalities in children under 1-year-of-age. Children may die due to airway obstruction by food objects such as hot dogs, nuts, candies, grapes, seeds, and egg sh... | ['Adolescent', 'Airway Obstruction', 'Cause of Death', 'Child', 'Child, Preschool', 'Female', 'Food', 'Foreign Bodies', 'Humans', 'Illinois', 'Infant', 'Male'] | 8,871,384 | [['M01.060.057'], ['C08.618.846.185'], ['E05.318.308.985.550.250', 'N01.224.935.698.100', 'N06.850.505.400.975.550.250', 'N06.850.520.308.985.550.250'], ['M01.060.406'], ['M01.060.406.448'], ['G07.203.300', 'J02.500'], ['C26.392'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.107.567.875.350.350', 'Z01.107.56... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
Mantle cell lymphoma: from ultrasound examination to histological diagnosis. | We report the case of a 42-year-old patient referred to our department for the examination of two large, symmetrical inguinal lumps. The ultrasound examination of the swollen lymph node demonstrated a cortical echogenicity greater than the medullary echogenicity, and the vascularization stop around the cortical zone su... | ['Adult', 'Diagnosis, Differential', 'Humans', 'Lymph Nodes', 'Lymphoma, Mantle-Cell', 'Ultrasonography'] | 30,132,201 | [['M01.060.116'], ['E01.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A10.549.400', 'A15.382.520.604.412'], ['C04.557.386.480.525', 'C15.604.515.569.480.525', 'C20.683.515.761.480.525'], ['E01.370.350.850']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Pentoxifylline Added to Steroid Window Treatment Phase Modified Apoptotic Gene Expression in Pediatric Patients With Acute Lymphoblastic Leukemia. | Pentoxifylline is a xanthine that possesses antitumor properties and that can induce higher apoptosis in the leukemic cells of pediatric patients with acute lymphoblastic leukemia (ALL) during treatment with prednisone. We conducted a phase 1 pilot, controlled, randomized trial to evaluate the gene expression modified ... | ['Adolescent', 'Apoptosis', 'Child', 'Child, Preschool', 'Female', 'Gene Expression Regulation, Leukemic', 'Humans', 'Infant', 'Male', 'Pentoxifylline', 'Pilot Projects', 'Precursor Cell Lymphoblastic Leukemia-Lymphoma', 'Prednisone'] | 29,683,943 | [['M01.060.057'], ['G04.146.954.035'], ['M01.060.406'], ['M01.060.406.448'], ['G05.308.370.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['D03.633.100.759.758.824.651.700'], ['E05.318.372.750', 'E05.337.737', 'N05.715.360.330.720', 'N06.850.520.450.720'], ['C04.557.337.428.600', 'C15.604.515.... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Boosting bandwidth. | The good news is that newer, faster technology is opening up new horizons for networked applications. The bad news? Figuring out how much bandwidth to install to meet future demands, without overbuilding and suffering a poor ROI. | ['Computer Communication Networks', 'Computers', 'Diffusion of Innovation', 'Technology Transfer', 'Telecommunications', 'Time Management', 'United States'] | 10,169,816 | [['L01.224.230.110'], ['L01.224.230.260'], ['L01.143.320'], ['J01.897.900', 'L01.143.320.800'], ['L01.178.847'], ['F02.784.412.923', 'F02.784.692.816', 'F04.096.628.779.900', 'N04.452.932'], ['Z01.107.567.875']] | ['Information Science [L]', 'Technology, Industry, and Agriculture [J]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 |
Cleanup of extracts using sweep co-distillation adapted to gas chromatograph. | An adaptation of the Varian Aerograph gas chromatograph to the sweep co-distillation cleanup using the modified Storherr tube is described. The recoveries of this cleanup technique were evaluated for the mixture of four organophosphoru pesticides added to extracts from ten crop and milk. Pesticides were analyzed by gas... | ['Animals', 'Chromatography, Gas', 'Fenitrothion', 'Fruit', 'Insecticides', 'Malathion', 'Milk', 'Plant Extracts', 'Vegetables'] | 1,173,556 | [['B01.050'], ['E05.196.181.349'], ['D02.705.400.625.300', 'D02.705.539.345.300', 'D02.886.300.692.300'], ['A18.024.500', 'G07.203.300.562', 'J02.500.562'], ['D27.720.031.700.491', 'D27.888.723.491'], ['D02.705.400.625.500', 'D02.705.539.345.500', 'D02.886.300.692.500'], ['A12.200.455', 'A12.790', 'G07.203.100.700', 'G... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Identification of a novel polyfluorinated compound as a lead to inhibit the human enzymes aldose reductase and AKR1B10: structure determination of both ternary complexes and implications for drug design. | Aldo-keto reductases (AKRs) are mostly monomeric enzymes which fold into a highly conserved (á/â)8 barrel, while their substrate specificity and inhibitor selectivity are determined by interaction with residues located in three highly variable external loops. The closely related human enzymes aldose reductase (AR or AK... | ['Aldehyde Reductase', 'Aldo-Keto Reductases', 'Carboxylic Acids', 'Crystallography, X-Ray', 'Drug Design', 'Enzyme Stability', 'Halogens', 'Humans', 'Molecular Dynamics Simulation', 'Mutagenesis, Site-Directed', 'NADP', 'Recombinant Proteins'] | 24,598,757 | [['D08.811.682.047.150.700.156.500', 'D08.811.682.047.820.284.500'], ['D08.811.682.047.150.700.156', 'D08.811.682.047.820.284'], ['D02.241'], ['E05.196.309.742.225'], ['E05.290.500', 'H01.158.703.007.338.500', 'H01.181.466.338.500'], ['E05.916.360', 'G02.111.700.500'], ['D01.268.380'], ['B01.050.150.900.649.313.988.400... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Information Science [L]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Sustained attention deficits in rats with chronic inflammatory pain. | Attentional deficits are a common clinical manifestation in chronic pain patients. The causes for this impairment are not clear, and explanations range from distraction caused by painful feelings to pain-induced putative alterations of brain regions related to attention processing. However, none of these explanations h... | ['Animals', 'Arthritis, Experimental', 'Attention', 'Chronic Disease', "Freund's Adjuvant", 'Mycobacterium', 'Pain', 'Rats'] | 19,631,256 | [['B01.050'], ['C05.550.114.015', 'E05.598.500.249'], ['F02.830.104.214'], ['C23.550.291.500'], ['D20.475'], ['B03.510.024.962.500', 'B03.510.460.400.410.552.552'], ['C23.888.592.612', 'F02.830.816.444', 'G11.561.790.444'], ['B01.050.150.900.649.313.992.635.505.700']] | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Ginsenoside Rb1 promotes browning through regulation of PPARã in 3T3-L1 adipocytes. | Browning of white adipocyte tissue (WAT) has received considerable attention due to its potential implication in preventing obesity and related comorbidities. Ginsenoside Rb1 is reported to improve glycolipid metabolism and reduce body weight in obese animals. However whether the body reducing effect mediates by browni... | ['3T3-L1 Cells', 'Adipocytes, Brown', 'Adipocytes, White', 'Anilides', 'Animals', 'Cell Differentiation', 'DNA-Binding Proteins', 'Energy Metabolism', 'Ginsenosides', 'Glucose', 'Ion Channels', 'Mice', 'Mitochondrial Proteins', 'Oxygen Consumption', 'PPAR gamma', 'Peroxisome Proliferator-Activated Receptor Gamma Coacti... | 26,381,176 | [['A11.251.210.100.775.800', 'A11.329.228.100.775.800'], ['A11.329.114.249'], ['A11.329.114.500'], ['D02.065.199', 'D02.092.146.113'], ['B01.050'], ['G04.152'], ['D12.776.260'], ['G03.295'], ['D02.455.849.919.277', 'D09.408.782.300'], ['D09.947.875.359.448'], ['D12.776.157.530.400', 'D12.776.543.550.450', 'D12.776.543.... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Serum total and bioavailable testosterone levels, central obesity, and muscle strength changes with aging in healthy Chinese men. | OBJECTIVES: To investigate the effects of the changes in serum bioavailable and total testosterone (TT) levels with aging on visceral body fat distribution and muscle strength in Chinese men.DESIGN: Cross-sectional study.SETTING: Ambulatory care.PARTICIPANTS: Four hundred seventy-five healthy ambulatory Chinese men (ag... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Aging', 'Androgens', 'Biological Availability', 'Body Mass Index', 'China', 'Cross-Sectional Studies', 'Humans', 'Male', 'Middle Aged', 'Muscle Strength', 'Obesity', 'Testosterone'] | 18,482,300 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['G07.345.124'], ['D27.505.696.399.472.161'], ['G03.787.151', 'G07.690.725.129'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['Z01.252.474.164'], ['E05.318.372.500.875', 'N05.715.360.330.5... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
[Relationship between extent of tumor resection and prognosis: an evaluation in 533 cases of gastric cancer]. | OBJECTIVE: To evaluate prognosis of patients with stomach cancer based on the extent of tumor resection.METHODS: Five hundred and thirty-three cases of gastric cancer resected from 1980 through 1990 were divided into 3 categories A, B, and C, in the order of decreasing completeness of tumor resection as set forth in th... | ['Adult', 'Aged', 'Aged, 80 and over', 'Female', 'Humans', 'Lymph Node Excision', 'Lymphatic Metastasis', 'Male', 'Middle Aged', 'Prognosis', 'Stomach Neoplasms', 'Survival Rate'] | 11,776,630 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.446'], ['C04.697.650.560', 'C23.550.727.650.560'], ['M01.060.116.630'], ['E01.789'], ['C04.588.274.476.767', 'C06.301.371.767', 'C06.405.249.767', 'C06.405.748.789'], ['E05.318.308.985.550.900', 'N01.2... | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Intrinsically Disordered Stress Protein COR15A Resides at the Membrane Surface during Dehydration. | Plants from temperate climate zones are able to increase their freezing tolerance during exposure to low, above-zero temperatures in a process termed cold acclimation. During this process, several cold-regulated (COR) proteins are accumulated in the cells. One of them is COR15A, a small, intrinsically disordered protei... | ['Arabidopsis Proteins', 'Cell Membrane', 'Phosphatidylcholines', 'Protein Conformation, alpha-Helical', 'Protein Folding', 'Surface Properties', 'Water'] | 28,793,212 | [['D12.776.765.149'], ['A11.284.149'], ['D10.570.755.375.760.400.800'], ['G02.111.570.820.709.600.020'], ['G01.154.651', 'G02.111.688'], ['G02.860'], ['D01.045.250.875', 'D01.248.497.158.459.650', 'D01.650.550.925']] | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A Population-Based Study of Cholesterol Measurements in the Oldest Old. | BACKGROUND: Effect of lipid-lowering treatment in the oldest old is a matter of debate as there is no unequivocal evidence of statins being beneficial among the oldest. The need for cholesterol measurements is therefore also questionable, but the frequency of cholesterol measurements in the oldest old has not been desc... | ['Aged, 80 and over', 'Cholesterol', 'Female', 'Humans', 'Male'] | 26,329,161 | [['M01.060.116.100.080'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['B01.050.150.900.649.313.988.400.112.400.400']] | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Folding simulations of a three-stranded antiparallel beta -sheet peptide. | Protein folding is a grand challenge of the postgenomic era. In this paper, 58 folding events sampled during 47 molecular dynamics trajectories for a total simulation time of more than 4 micros provide an atomic detail picture of the folding of a 20-residue synthetic peptide with a stable three-stranded antiparallel be... | ['Models, Molecular', 'Peptides', 'Protein Folding'] | 10,984,515 | [['E05.599.595'], ['D12.644'], ['G01.154.651', 'G02.111.688']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Treatment of headaches among the Aborigines of Tierra de Fuego. A comparison with other anthropological studies]. | SUMMARY INTRODUCTION: Several different indigenous groups (Yamana, Selk'nam, Alacaluf, Haush) used to inhabit the Patagonian region of Tierra de Fuego, but are now extinct.AIM: To analyse the healing practices that these prehistoric aborigines used to treat headaches and to compare them with those observed in other ant... | ['Anthropology, Physical', 'Argentina', 'Headache', 'History, 19th Century', 'History, 20th Century', 'Humans', 'Indians, South American', 'Medicine, Traditional'] | 18,841,550 | [['I01.076.368'], ['Z01.107.757.077'], ['C23.888.592.612.441'], ['K01.400.504.937'], ['K01.400.504.968'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.686.508.150.625'], ['E02.190.488', 'I01.076.201.450.654']] | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]', 'Diseases [C]', 'Humanities [K]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 |
Characterization of the metal-binding sites of the beta-lactamase from Bacteroides fragilis. | In an effort to better understand the structure and function of the metallo-beta-lactamase from Bacteroides fragilis, spectroscopic and metal-binding studies were performed on the native, metal-substituted, and mutant forms of the enzyme. Atomic absorption studies demonstrate that the native B. fragilis enzyme tightly ... | ['Bacteroides fragilis', 'Binding Sites', 'Cations, Divalent', 'Cloning, Molecular', 'DNA Primers', 'Electron Spin Resonance Spectroscopy', 'Escherichia coli', 'Kinetics', 'Magnetic Resonance Spectroscopy', 'Metals', 'Mutagenesis, Site-Directed', 'Point Mutation', 'Polymerase Chain Reaction', 'Protein Conformation', 'R... | 8,810,919 | [['B03.440.080.094.152.400', 'B03.440.425.410.194.152.400'], ['G02.111.570.120'], ['D01.248.497.300.333'], ['E05.393.220'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['E05.196.867.519.274'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['G01.374.661', 'G02.111.490'], ['E05.196.867.519'], ['... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Impact of live attenuated influenza vaccination programme for healthy children in Northern Ireland: A comparison of seven influenza seasons, 2010/11-2016/17. | Seasonal influenza vaccination for healthy children was introduced in Northern Ireland in the 2013/14 flu season, with an initial pilot year involving two specific cohorts, followed by rollout to all children aged 4-11 years in subsequent seasons. This study aimed to examine the impact of that programme on the burden o... | ['Child', 'Child, Preschool', 'Female', 'Humans', 'Immunization Programs', 'Incidence', 'Influenza Vaccines', 'Influenza, Human', 'Male', 'Northern Ireland', 'Outcome Assessment, Health Care', 'Seasons', 'Vaccination', 'Vaccines, Attenuated'] | 29,275,988 | [['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N02.421.726.608'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.985.525.375'], ['D20.215.894.899.302'], ['C01.748.310', 'C01.925.782.620.365', 'C08.730.310'], ['Z01.542.363.602... | ['Named Groups [M]', 'Organisms [B]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Geographicals [Z]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
Progesterone receptors induce FOXO1-dependent senescence in ovarian cancer cells. | Loss of nuclear progesterone receptors (PR) and low circulating progesterone levels are associated with increased ovarian cancer (OC) risk. However, PR are abundantly expressed in a significant percentage of serous and endometrioid ovarian tumors; patients with PR+ tumors typically experience longer progression-free su... | ['Cell Line, Tumor', 'Cell Proliferation', 'Cell Survival', 'Cellular Senescence', 'Cyclin-Dependent Kinase Inhibitor p21', 'Female', 'Forkhead Box Protein O1', 'Forkhead Transcription Factors', 'Gene Expression Regulation, Neoplastic', 'Green Fluorescent Proteins', 'Humans', 'Models, Biological', 'Ovarian Neoplasms', ... | 23,574,718 | [['A11.251.210.190', 'A11.251.860.180'], ['G04.161.750', 'G07.345.249.410.750'], ['G04.346'], ['G04.043'], ['D12.644.360.225.500', 'D12.776.157.687.250', 'D12.776.167.187.500', 'D12.776.476.225.500', 'D12.776.624.776.355.500', 'D12.776.660.720.250'], ['D12.776.260.950.249.250', 'D12.776.930.977.249.250'], ['D12.776.260... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
PE859, A Novel Curcumin Derivative, Inhibits Amyloid-â and Tau Aggregation, and Ameliorates Cognitive Dysfunction in Senescence-Accelerated Mouse Prone 8. | Aggregation of amyloid-â (Aâ) and tau plays a crucial role in the onset and progression of Alzheimer's disease (AD). Therefore, the inhibition of Aâ and tau aggregation may represent a potential therapeutic target for AD. Herein, we designed and synthesized both Aâ and tau dual aggregation inhibitors based on the struc... | ['Aging', 'Amyloid beta-Peptides', 'Animals', 'Brain', 'Cell Line, Tumor', 'Cognition Disorders', 'Disease Models, Animal', 'Dose-Response Relationship, Drug', 'Humans', 'Indoles', 'L-Lactate Dehydrogenase', 'Maze Learning', 'Mice', 'Mice, Transgenic', 'Microscopy, Electron, Transmission', 'Motor Activity', 'Neuroblast... | 28,598,836 | [['G07.345.124'], ['D12.644.024', 'D12.776.049.407.249.500', 'D12.776.543.039.500'], ['B01.050'], ['A08.186.211'], ['A11.251.210.190', 'A11.251.860.180'], ['F03.615.250'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['G07.690.773.875', 'G07.690.936.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.633.10... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Reactions between M+ (M = Si, Ge, Sn and Pb) and benzene in the gas phase. | Using a laser ablation/inert buffer gas ion source coupled with a reflectron time-of-flight mass spectrometer, the gas-phase reactions between the IVA group element ions M(+) (M = Si, Ge, Sn and Pb) and benzene seeded in argon gas were studied. In addition to the association reaction pathway (forming [M(C(6)H(6))(x)](+... | ['Benzene', 'Gases', 'Germanium', 'Lead', 'Mass Spectrometry', 'Metals', 'Organometallic Compounds', 'Silicon', 'Tin'] | 12,872,279 | [['D02.455.426.559.389.023'], ['D01.362'], ['D01.268.513.750', 'D01.268.556.305', 'D01.552.544.305'], ['D01.268.556.435', 'D01.552.544.435'], ['E05.196.566'], ['D01.552'], ['D02.691'], ['D01.268.513.937'], ['D01.268.556.875', 'D01.552.544.875']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Sigma1 receptor modulation of opioid analgesia in the mouse. | Opioid analgesia is influenced by many factors, including the sigma1 receptor system. Current studies show the importance of supraspinal mechanisms in these sigma1actions. Given supraspinally, the sigma1receptor agonist (+)pentazocine diminished systemic mu, delta, kappa1, and kappa3 opioid analgesia in CD-1 mice. Ther... | ['Analgesics, Opioid', 'Animals', 'Central Nervous System', 'Down-Regulation', 'Drug Synergism', 'Haloperidol', 'Injections, Spinal', 'Male', 'Mice', 'Mice, Inbred BALB C', 'Narcotic Antagonists', 'Oligodeoxyribonucleotides, Antisense', 'Pain Measurement', 'Pentazocine', 'Receptors, sigma'] | 11,861,817 | [['D27.505.696.277.600.500', 'D27.505.696.663.850.014.760.500', 'D27.505.954.427.040.550.500', 'D27.505.954.427.210.600.500'], ['B01.050'], ['A08.186'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['G07.690.773.968.477'], ['D02.522.352.506'], ['E02.319.267.530.580'], ['B01.050.150.900.649.313.992.635.505.500'], ... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Orthodontic treatment in a periodontal patient with pathologic migration of anterior teeth. | A 22-year-old man with severe periodontitis and pathologic tooth migration sought orthodontic treatment. He was treated successfully with effective control of the strength and the direction of the orthodontic forces, and a combination of periodontic and orthodontic treatment. After 22 months of orthodontic treatment, h... | ['Alveolar Bone Loss', 'Cephalometry', 'Dental Occlusion, Traumatic', 'Esthetics', 'Gingival Recession', 'Humans', 'Incisor', 'Male', 'Malocclusion', 'Occlusal Splints', 'Orthodontics, Corrective', 'Patient Care Planning', 'Patient Care Team', 'Periodontal Pocket', 'Periodontitis', 'Self Concept', 'Tooth Migration', 'T... | 24,785,933 | [['C05.116.264.150', 'C07.465.714.354.500'], ['E01.370.600.024.250', 'E05.041.250', 'N06.850.505.200.100.300'], ['C07.793.494.293'], ['F02.463.785.477', 'K01.752.210'], ['C07.465.714.258.447', 'C07.465.714.354.625'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A14.549.167.860.425'], ['C07.793.494'], ['E07.858.44... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Humanities [K]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Named Groups [M]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Bacterial transport experiments in fractured crystalline bedrock. | The efficiency of contaminant biodegradation in ground water depends, in part, on the transport properties of the degrading bacteria. Few data exist concerning the transport of bacteria in saturated bedrock, particularly at the field scale. Bacteria and microsphere tracer experiments were conducted in a fractured cryst... | ['Bacteria', 'Biodegradation, Environmental', 'Geological Phenomena', 'Geology', 'Population Dynamics', 'Soil Microbiology', 'Soil Pollutants', 'Water Movements', 'Water Pollutants', 'Water Supply'] | 13,678,122 | [['B03'], ['N06.230.080.600.500', 'N06.850.460.375.500'], ['G01.311'], ['H01.277.562'], ['I01.240.600', 'N01.224.625', 'N06.850.505.400.700'], ['H01.158.273.540.274.555', 'N06.850.425.300'], ['D27.888.284.756'], ['G16.500.971', 'N06.230.132.644.750', 'N06.230.850'], ['D27.888.284.903'], ['J01.293.821.500']] | ['Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 |
Angiogenic growth factor levels in maternal and fetal blood: correlation with Doppler ultrasound parameters in pregnancies complicated by pre-eclampsia and intrauterine growth restriction. | OBJECTIVES: To correlate levels of angiogenic growth factors with Doppler ultrasound parameters in pregnancies complicated by pre-eclampsia and intrauterine growth restriction (IUGR).METHODS: In 16 women with pre-eclampsia and 15 women with isolated IUGR, pulsatility indices (PI) in the umbilical and uterine arteries w... | ['Adult', 'Angiogenesis Inducing Agents', 'Arteries', 'Biomarkers', 'Female', 'Fetal Blood', 'Fetal Growth Retardation', 'Humans', 'Pre-Eclampsia', 'Pregnancy', 'Pulsatile Flow', 'Ultrasonography, Doppler', 'Ultrasonography, Prenatal', 'Umbilical Arteries', 'Uterus'] | 17,330,322 | [['M01.060.116'], ['D27.505.696.377.077.077'], ['A07.015.114'], ['D23.101'], ['A12.207.152.200', 'A15.145.300', 'A16.378.200'], ['C13.703.277.370', 'C16.300.390', 'C23.550.393.450'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C13.703.395.249'], ['G08.686.784.769'], ['G01.482.620', 'G09.330.380.630.555'], ['E01.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Some ecomorphologic aspects of nodular goiter]. | AIM OF THE STUDY: Determine microcalcifications' rule in nodular goiter, to classify those calcifications and identify US features suspect for tumoral pathology.MATERIAL AND METHODS: In Endocrine Surgery Unit we ultrasonographically detected 655 patients in a period of twelve months (Jan to Dec 2005). Patients aged fro... | ['Adult', 'Aged', 'Calcinosis', 'Diagnosis, Differential', 'Female', 'Goiter, Nodular', 'Humans', 'Incidence', 'Male', 'Middle Aged', 'Precancerous Conditions', 'Prevalence', 'Retrospective Studies', 'Sensitivity and Specificity', 'Sicily', 'Thyroiditis', 'Ultrasonography'] | 17,518,324 | [['M01.060.116'], ['M01.060.116.100'], ['C18.452.174.130'], ['E01.171'], ['C19.874.283.501'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.985.525.375'], ['M01.060.116.630'], ['C04.834'], ['E05.318.308.985.525.750', '... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
A rare variant of gallstone ileus: Bouveret's syndrome. | INTRODUCTION: Bouveret's syndrome (gastric outlet obstruction due to impaction of a stone) is a rare variant of gallstone ileus. A recently observed case led us to review the literature, with the aim to discuss the recent advances in the management of this rare syndrome.DISCUSSION: A 69-year-old woman was admitted with... | ['Aged', 'Cholelithiasis', 'Diagnosis, Differential', 'Female', 'Gastric Outlet Obstruction', 'Humans', 'Syndrome', 'Tomography, X-Ray Computed'] | 19,421,821 | [['M01.060.116.100'], ['C06.130.409'], ['E01.171'], ['C06.405.748.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.288.500'], ['E01.370.350.350.810', 'E01.370.350.600.350.700.810', 'E01.370.350.700.700.810', 'E01.370.350.700.810.810', 'E01.370.350.825.810.810']] | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Hemimicelle capped functionalized carbon nanotubes-based nanosized solid-phase extraction of arsenic from environmental water samples. | The end functionalization of CNTs can introduce oxygen-containing negatively functional groups such as -COOH, -OH, or -CO on their surface site. If cationic surfactant such as cetyltrimethylammonium chloride (CTAC) was added to the functionalized CNTs, then interactions such as hydrophobic and ionic may lead to formati... | ['Adsorption', 'Arsenic', 'Electrolytes', 'Environmental Pollutants', 'Hydrogen-Ion Concentration', 'Micelles', 'Nanotubes, Carbon', 'Reproducibility of Results', 'Sensitivity and Specificity', 'Solid Phase Extraction', 'Surface-Active Agents', 'Time Factors', 'Ultrasonics', 'Water'] | 19,084,624 | [['G01.030', 'G02.020'], ['D01.268.513.249'], ['D01.248'], ['D27.888.284'], ['G02.300'], ['D05.374', 'D26.255.560'], ['D01.268.150.250.500', 'J01.637.512.850.500'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700', ... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 |
Antagonistic effects of chloroquine on autophagy occurrence potentiate the anticancer effects of everolimus on renal cancer cells. | Renal cell carcinoma is an aggressive disease often asymptomatic and weakly chemo-radiosensitive. Currently, new biologic drugs are used among which everolimus, an mTOR inhibitor, that has been approved for second-line therapy. Since mTOR is involved in the control of autophagy, its antitumor capacity is often limited.... | ['Antineoplastic Agents', 'Apoptosis', 'Apoptosis Regulatory Proteins', 'Autophagy', 'Beclin-1', 'Carcinoma, Renal Cell', 'Cell Line, Tumor', 'Cell Survival', 'Chloroquine', 'Drug Synergism', 'Everolimus', 'Humans', 'Kidney Neoplasms', 'Lysosomes', 'Membrane Proteins', 'Mitochondria', 'Proto-Oncogene Proteins c-bcl-2',... | 25,866,016 | [['D27.505.954.248'], ['G04.146.954.035'], ['D12.644.360.075', 'D12.776.476.075'], ['G04.011'], ['D12.644.360.075.335', 'D12.776.094.500', 'D12.776.476.075.335'], ['C04.557.470.200.025.390', 'C04.588.945.947.535.160', 'C12.758.820.750.160', 'C12.777.419.473.160', 'C13.351.937.820.535.160', 'C13.351.968.419.473.160'], [... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Biochemical markers of bone metabolism during distance running in healthy, regularly exercising men and women. | The purpose of the present study was to evaluate the effects of long distance running on bone metabolism, using the biochemical markers ICTP (the carboxyterminal cross-linked telopeptide of type I collagen), PICP (the carboxyterminal propeptide of type I procollagen), osteocalcin and bALP (bone specific alkaline phosph... | ['Adult', 'Biomarkers', 'Bone and Bones', 'Collagen', 'Exercise', 'Female', 'Humans', 'Male', 'Middle Aged', 'Osteocalcin', 'Parathyroid Hormone', 'Peptide Fragments', 'Physical Endurance', 'Procollagen', 'Running'] | 8,680,940 | [['M01.060.116'], ['D23.101'], ['A02.835.232', 'A10.165.265'], ['D05.750.078.280', 'D12.776.860.300.250'], ['G11.427.410.698.277', 'I03.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['D12.776.157.125.700'], ['D06.472.699.590', 'D12.644.548.587'], ['D12.644.541'], ['G11.427.680', 'I03.450.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Sedimentation rates and erosion processes in the lagoon of Venice. | Since the early 1990s in the lagoon of Venice, especially in the central basin, the surface sediment underwent high re-suspension and sedimentation changes and water turbidity increased both because of the disappearance of the macroalgal coverage and the harvesting of the Manila clam Tapes philippinarum Adams and Reeve... | ['Animals', 'Bivalvia', 'Cities', 'Environmental Monitoring', 'Food Chain', 'Geologic Sediments', 'Italy', 'Risk Assessment', 'Seawater', 'Time Factors', 'Water Pollutants, Chemical'] | 16,083,960 | [['B01.050'], ['B01.050.500.644.080'], ['G16.500.275.069', 'N06.230.069', 'Z01.433'], ['N06.850.460.350.080', 'N06.850.780.375'], ['G16.500.275.157.250', 'N06.230.124.250'], ['G01.311.330', 'G16.500.320'], ['Z01.542.489'], ['E05.318.740.600.800.715', 'N04.452.871.715', 'N05.715.360.750.625.700.690', 'N06.850.505.715', ... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
A finite element model for investigating effects of aerial architecture on tree oscillations. | A finite element model was developed to study the influence of aerial architecture on the structural dynamics of trees. The model combines a complete description of the axes of the aerial architecture of the plant with numerical techniques suitable for dynamic nonlinear analyses. Trees were modeled on the basis of morp... | ['Biomechanical Phenomena', 'Models, Biological', 'Pinus', 'Plant Roots', 'Plant Stems', 'Trees', 'Vibration'] | 16,510,396 | [['G01.154.090', 'G01.374.089'], ['E05.599.395'], ['B01.650.940.800.575.912.625.875.777'], ['A18.400'], ['A18.024.937'], ['B01.650.915'], ['G01.374.930']] | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The problem of overcontrol: Perfectionism, emotional inhibition, and personality disorders. | BACKGROUND AND AIMS: Some individuals with Personality Disorders (PD), particularly of a non-Borderline type, present with difficulties relating to over-control of cognitions, emotion and behavior, perfectionistic traits, and impaired social interactions. The current study sought to evaluate the strength of association... | ['Adolescent', 'Adult', 'Aged', 'Anxiety Disorders', 'Cognition', 'Depression', 'Emotions', 'Female', 'Humans', 'Inhibition, Psychological', 'Male', 'Middle Aged', 'Perfectionism', 'Personality Disorders', 'Self Report', 'Young Adult'] | 29,621,675 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['F03.080'], ['F02.463.188'], ['F01.145.126.350'], ['F01.470'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.544', 'F02.463.425.475', 'F02.739.794.405'], ['M01.060.116.630'], ['F01.752.823'], ['F03.675'], ['E05.318.308.980.500', 'N05.715.360.300.800.... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Improving utilization of antimicrobial drugs among physician assistants in the ED. | OBJECTIVE: This study examines the effectiveness of an educational intervention that used audit and feedback to influence physician assistant (PA) antimicrobial utilization in an emergency department (ED).METHODS: Twelve ED PAs participated in this pre- and postintervention study. Their prescribing patterns were retros... | ['Adult', 'Anti-Infective Agents', 'Curriculum', 'Drug Utilization', 'Education, Medical, Continuing', 'Emergency Service, Hospital', 'Female', 'Humans', 'Male', 'Physician Assistants', "Practice Patterns, Physicians'"] | 22,010,565 | [['M01.060.116'], ['D27.505.954.122'], ['I02.158'], ['N04.452.706.477'], ['I02.358.212.350', 'I02.358.399.250'], ['N02.278.216.500.968.336', 'N02.421.297.195', 'N04.452.442.452.422.336'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.526.485.067.740', 'N02.360.067.740'], ['N04.590.374.577', 'N05.300.625']] | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
[Characteristics of lipid peroxidation in various tissues during acute stress and its correction by pyracetam and cerebrolysin]. | The process of lipid peroxidation (LPO), the activity of antioxidant enzymes, and the effects of piracetam (300 mg/kg) and cerebrolysin (0.1 ml/kg) were studied in the brain, liver, thymus, spleen, and blood serum of white male rats under acute stress (immobilization) conditions. The results of analyses confirmed that ... | ['Acute Disease', 'Amino Acids', 'Animals', 'Antioxidants', 'Brain', 'Catalase', 'Ceruloplasmin', 'Lipid Peroxidation', 'Liver', 'Male', 'Nootropic Agents', 'Organ Specificity', 'Piracetam', 'Rats', 'Spleen', 'Stress, Psychological', 'Superoxide Dismutase', 'Thiobarbituric Acid Reactive Substances', 'Thymus Gland'] | 11,022,305 | [['C23.550.291.125'], ['D12.125'], ['B01.050'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['A08.186.211'], ['D08.811.682.732.332'], ['D08.811.682.226', 'D12.776.124.050.130', 'D12.776.124.790.106.214', 'D12.776.157.160', 'D12.776.377.715.085.214', 'D12.776.556.151'], ['G02.111.515', 'G03.295.531.58... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Rapid-onset "need-free" sodium appetite after lesions of the dorsomedial medulla. | Previous studies indicate the dorsomedial hindbrain is important in the maintenance of fluid balance. Lesions centering on the area postrema (AP) result in enhanced ad libitum intake of concentrated saline solutions on a 24-h basis as well as enhanced excretion of water and electrolytes. Additionally, rats with lesions... | ['Animals', 'Appetite', 'Behavior, Animal', 'Diet, Sodium-Restricted', 'Drinking', 'Furosemide', 'Male', 'Medulla Oblongata', 'Nephrectomy', 'Rats', 'Rats, Sprague-Dawley', 'Sodium', 'Sodium Chloride'] | 8,322,980 | [['B01.050'], ['F02.830.071', 'G07.203.650.390.070', 'G10.261.390.070'], ['F01.145.113'], ['E02.642.249.290', 'G07.203.650.240.290'], ['G07.203.650.283.249', 'G10.261.330.249'], ['D02.065.884.725.300', 'D02.092.146.807.300', 'D02.886.590.700.725.300'], ['A08.186.211.132.810.591.500'], ['E04.950.774.435'], ['B01.050.150... | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Tolerance and metabolic results of long-term administration of a mixture of saturated triglycerides by recto-colic route in rabbits]. | Rabbit's and Dog's colonic absorption of triglycerides is shown in previous works. Further, we are studying the possibility to use the rectal route for nutritive substances. This way remains now poorly used and an exceptional therapeutic. However, bringing triglycerides in adequate state would be an energetic, supply, ... | ['Animals', 'Colon', 'Intestinal Absorption', 'Kidney', 'Lipids', 'Liver', 'Male', 'Rabbits', 'Rectum', 'Triglycerides'] | 1,029,424 | [['B01.050'], ['A03.556.124.526.356', 'A03.556.249.249.356'], ['G03.015.500.374.500', 'G03.787.024.500.374.500', 'G07.203.650.372.500', 'G07.690.725.015.500.374.500', 'G10.261.353.500'], ['A05.810.453'], ['D10'], ['A03.620'], ['B01.050.150.900.649.313.968.700'], ['A03.556.124.526.767', 'A03.556.249.249.767'], ['D10.351... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Improving the physical diagnosis skills of third-year medical students: a controlled trial of a literature-based curriculum. | OBJECTIVE: To determine if a literature-based physical diagnosis curriculum could improve student knowledge, skill, and self-confidence in physical diagnosis.DESIGN: Prospective controlled trial of an educational intervention.SETTING: Required internal medicine clerkship for third-year medical students at Brown Medical... | ['Clinical Clerkship', 'Clinical Competence', 'Curriculum', 'Female', 'Humans', 'Internal Medicine', 'Male', 'Physical Examination', 'Problem-Based Learning', 'Prospective Studies', 'Rhode Island', 'Self-Assessment', 'Students, Medical'] | 12,911,648 | [['I02.358.105'], ['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['I02.158'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H02.403.429'], ['E01.370.600'], ['F02.463.425.720', 'I02.158.660', 'I02.903.565'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['Z01.107.567... | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]', 'Named Groups [M]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Flura-seq identifies organ-specific metabolic adaptations during early metastatic colonization. | Metastasis-initiating cells dynamically adapt to the distinct microenvironments of different organs, but these early adaptations are poorly understood due to the limited sensitivity of in situ transcriptomics. We developed fluorouracil-labeled RNA sequencing (Flura-seq) for in situ analysis with high sensitivity. Flura... | ['Animals', 'Breast Neoplasms', 'Cell Separation', 'Disease Models, Animal', 'Heterografts', 'Mice', 'Neoplasm Micrometastasis', 'Neoplasm Transplantation', 'Pathology, Molecular', 'Sequence Analysis, RNA', 'Staining and Labeling'] | 30,912,515 | [['B01.050'], ['C04.588.180', 'C17.800.090.500'], ['E01.370.225.500.363', 'E05.200.500.363', 'E05.242.363'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['A01.941.875'], ['B01.050.150.900.649.313.992.635.505.500'], ['C04.697.650.695', 'C23.550.727.650.695'], ['E05.624'], ['H01.158.201.636.475.750', 'H01.158.273.343.... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Measurement of left ventricular volumes and ejection fraction after intravenous contrast agent administration using standard echocardiographic equipment. | The enhancement of endocardial border delineation using second harmonic imaging and contrast administration improves the measurement of ventricular volumes. In the majority of existing echocardiographic equipment, however, harmonic imaging is not yet available. The aim of this study was to assess the feasibility of the... | ['Cardiomyopathy, Dilated', 'Contrast Media', 'Echocardiography', 'Feasibility Studies', 'Humans', 'Injections, Intravenous', 'Middle Aged', 'Myocardial Infarction', 'Observer Variation', 'Polysaccharides', 'Reproducibility of Results', 'Stroke Volume'] | 10,979,016 | [['C14.280.195.160', 'C14.280.238.070', 'C16.320.488.750'], ['D27.505.259.500', 'D27.720.259'], ['E01.370.350.130.750', 'E01.370.350.850.220', 'E01.370.370.380.220'], ['E05.318.372.550', 'E05.337.675', 'N05.715.360.330.550', 'N06.850.520.450.550'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.267.082.750'... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Evidence for the involvement of the Ss protein of the mouse in the hemolytic complement system. | A significant within-strain correlation has been demonstrated between the levels of Ss and hemolytic complement (C) activity in two Ss-high strains. Mouse serum specifically depleted of Ss by absorption with F(ab')2 fragments of anti-Ss had negligible C activity. In control experiments, Ss-specific antigen-antibody com... | ['Animals', 'Blood Proteins', 'Complement Fixation Tests', 'Complement System Proteins', 'Hemolysis', 'Immune Sera', 'Immunodiffusion', 'Immunogenetics', 'Immunoglobulin Fab Fragments', 'Immunoglobulin G', 'Male', 'Mice', 'Mice, Inbred Strains', 'Rabbits', 'Serum Albumin, Bovine'] | 805,206 | [['B01.050'], ['D12.776.124'], ['E01.370.225.812.735.150', 'E05.200.812.735.150', 'E05.478.594.760.150'], ['D12.776.124.486.274'], ['C23.550.403', 'G12.122.545'], ['A12.207.152.846.500', 'D12.776.124.486.485.114.573', 'D12.776.124.790.651.114.573', 'D12.776.377.715.548.114.573', 'D20.215.401'], ['E01.370.225.812.735.64... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Five-year outcomes of adjuvant carboplatin/paclitaxel chemotherapy and intravaginal radiation for stage I-II papillary serous endometrial cancer. | OBJECTIVE: The purpose of this study is to report our single-institution experience with concurrent adjuvant intravaginal radiation (IVRT) and carboplatin/paclitaxel chemotherapy for early stage uterine papillary serous carcinoma (UPSC).METHODS: From 10/2000 to 12/2009, 41 women with stage I-II UPSC underwent surgery f... | ['Aged', 'Aged, 80 and over', 'Antineoplastic Agents', 'Antineoplastic Combined Chemotherapy Protocols', 'Brachytherapy', 'Carboplatin', 'Chemoradiotherapy, Adjuvant', 'Cystadenocarcinoma, Papillary', 'Cystadenocarcinoma, Serous', 'Drug Administration Schedule', 'Endometrial Neoplasms', 'Female', 'Follow-Up Studies', '... | 22,850,412 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.954.248'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['E02.815.150'], ['D02.257.125'], ['E02.186.079.500', 'E02.319.164.500', 'E02.815.160.500'], ['C04.557.470.200.025.480.230', 'C04.557.470.590.480.230'], ['C04.557.470.200.025.480.240', 'C04.557... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Ataxia telangiectasia: presentation and diagnostic delay. | BACKGROUND AND AIMS: Ataxia telangiectasia (A-T) is a rare progressive, multisystem genetic disease. Families of children with ultra-rare diseases often experience significant diagnostic delays. We reviewed the diagnostic process for A-T in order to identify causes of delay in an attempt to facilitate earlier identific... | ['Age Factors', 'Ataxia Telangiectasia', 'Child', 'Child, Preschool', 'Delayed Diagnosis', 'Humans', 'Infant', 'Retrospective Studies', 'alpha-Fetoproteins'] | 27,799,156 | [['N05.715.350.075', 'N06.850.490.250'], ['C10.228.140.252.190.530.060', 'C10.562.100', 'C10.597.350.090.500.530.060', 'C14.907.823.213', 'C16.320.080', 'C16.320.798.250', 'C18.452.284.060', 'C20.673.795.250'], ['M01.060.406'], ['M01.060.406.448'], ['E01.110', 'E02.760.273', 'N02.421.585.273'], ['B01.050.150.900.649.31... | ['Health Care [N]', 'Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Functional characteristics of mesenchymal stem cells derived from bone marrow of patients with myelodysplastic syndromes. | Mesenchymal stem cells (MSCs) have emerged as excellent candidates for clinical application because of their capabilities of immunomodulatory and supporting hematopoiesis. Nevertheless, it is unclear whether the characteristics of MSCs are altered in diseased states. In this study, we obtained and expanded MSCs from bo... | ['Adult', 'Aged', 'Bone Marrow Cells', 'Cell Proliferation', 'Cells, Cultured', 'Cytokines', 'Female', 'Flow Cytometry', 'Gene Expression', 'Hematopoiesis', 'Humans', 'Immunophenotyping', 'Karyotype', 'Lymphocyte Activation', 'Male', 'Mesenchymal Stem Cells', 'Microscopy, Electron, Transmission', 'Middle Aged', 'Myelod... | 22,240,014 | [['M01.060.116'], ['M01.060.116.100'], ['A11.148', 'A15.378.316'], ['G04.161.750', 'G07.345.249.410.750'], ['A11.251'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.200.500.386.350', 'E05.242.363.... | ['Named Groups [M]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Moderation and mediation effects of coping by Chinese American and European American adolescents. | The authors asked 55 second-generation Chinese American adolescents (M age = 16.8 years) and 58 European American adolescents (M age = 17.0 years) to complete self-report measures of stress levels, use of coping strategies, psychological outcomes, and grades. Chinese American adolescents reported higher levels of every... | ['Adaptation, Psychological', 'Adolescent', 'Affect', 'Anxiety', 'Asian Americans', 'Attitude', 'Cross-Cultural Comparison', 'Depression', 'European Continental Ancestry Group', 'Female', 'Humans', 'Male', 'Social Adjustment', 'Somatoform Disorders', 'United States'] | 15,782,676 | [['F01.058'], ['M01.060.057'], ['F01.470.047'], ['F01.470.132'], ['M01.686.508.200.100', 'M01.686.754.225'], ['F01.100'], ['I01.076.201.450.281', 'I01.880.853.100.257'], ['F01.145.126.350'], ['M01.686.508.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.813.621'], ['F03.875'], ['Z01.107.567.875']] | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 |
Rapamycin-FKBP12 blocks proliferation, induces differentiation, and inhibits cdc2 kinase activity in a myogenic cell line. | Rapamycin is a potent immunosuppressant that binds to the cytosolic protein, FKBP12, and blocks T cell activation. Here we report that rapamycin also blocks myogenic proliferation and induces differentiation, associated with a decrease in p34cdc2 activity and cyclin A levels. In yeast and mammals, rapamycin blocks cell... | ['Animals', 'CDC2 Protein Kinase', 'Carrier Proteins', 'Cell Cycle', 'Cell Differentiation', 'Cell Division', 'Cell Line', 'Cyclins', 'Heat-Shock Proteins', 'Immunosuppressive Agents', 'Kinetics', 'Mice', 'Muscles', 'Polyenes', 'Sirolimus', 'Tacrolimus', 'Tacrolimus Binding Proteins'] | 7,503,980 | [['B01.050'], ['D08.811.913.696.620.682.700.646.500.500.250', 'D08.811.913.696.620.682.700.646.500.984.500', 'D12.644.360.250.067.249', 'D12.644.360.250.580.500', 'D12.776.167.200.067.249', 'D12.776.167.200.580.500', 'D12.776.476.250.067.249', 'D12.776.476.250.580.500', 'D12.776.744.360'], ['D12.776.157'], ['G04.144'],... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Citreoviridin inhibits cell proliferation and enhances apoptosis of human umbilical vein endothelial cells. | In some areas of China, citreoviridin (CIT) is considered one of the risk factors for development of cardiovascular disease (CVD). Apoptosis of endothelial cell may induce vascular endothelium injury and atherosclerosis, which result in CVD probably. In this study, we investigated the effect of CIT on apoptosis and pro... | ['Apoptosis', 'Aurovertins', 'Caspase 3', 'Caspase 9', 'Cell Cycle', 'Cell Proliferation', 'Cell Survival', 'Cells, Cultured', 'Cyclin B1', 'Cyclin D1', 'Cyclin-Dependent Kinase Inhibitor p21', 'Human Umbilical Vein Endothelial Cells', 'Humans', 'Mycotoxins', 'NF-kappa B', 'Proto-Oncogene Proteins c-bcl-2', 'Tumor Supp... | 24,637,250 | [['G04.146.954.035'], ['D03.383.663.075'], ['D08.811.277.656.262.500.126.350.300', 'D08.811.277.656.300.200.126.350.300', 'D12.644.360.075.405.350.300', 'D12.776.476.075.405.350.300'], ['D08.811.277.656.262.500.126.550.900', 'D08.811.277.656.300.200.126.550.900', 'D12.644.360.024.131.155', 'D12.644.360.075.358.155', 'D... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Two modified techniques to decrease complications of buried suture double-eyelid blepharoplasty. | BACKGROUND: Double-eyelid blepharoplasty is performed using two alternative approaches: the incision method and the suture method. Buried suture double-eyelid blepharoplasty involves implantation of a foreign material, that is, the suture thread. Therefore, potential complications caused by foreign material should be c... | ['Adolescent', 'Adult', 'Blepharoplasty', 'Child', 'Female', 'Humans', 'Male', 'Middle Aged', 'Oculomotor Muscles', 'Postoperative Complications', 'Retrospective Studies', 'Suture Techniques'] | 23,232,449 | [['M01.060.057'], ['M01.060.116'], ['E04.540.104', 'E04.680.275.090'], ['M01.060.406'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['A02.633.567.700'], ['C23.550.767'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.85... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Enzyme-linked immunosorbent assay for the detection of total cathepsin H in human tissue cytosols and sera. | An enzyme-linked immunosorbent assay (ELISA) was constructed for the determination of total human cathepsin H concentration in clinical samples. Utilising monoclonal and polyclonal antibodies, raised to human liver cathepsin H, the assay is able to detect a mature protein, a precursor molecule and enzyme-inhibitor comp... | ['Animals', 'Antibodies, Monoclonal', 'Cathepsin H', 'Cathepsins', 'Cysteine Endopeptidases', 'Cytosol', 'Enzyme-Linked Immunosorbent Assay', 'Humans', 'Isoelectric Point', 'Melanoma', 'Mice', 'Mice, Inbred BALB C', 'Neoplasm Metastasis'] | 9,050,938 | [['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D08.811.277.656.224.400', 'D08.811.277.656.262.500.153', 'D08.811.277.656.300.200.153', 'D23.050.301.500.600.300', 'D23.050.705.552.600.300'], ['D08.811.277.656.224'], ['D08.811.277.656.262.500', 'D08.811.277.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Organic air pollutants inside and outside residences in Shimizu, Japan: levels, sources and risks. | Concentrations of 38 organic air pollutants including aromatic hydrocarbons (AHCs), carbonyl compounds (CCs), volatile organic halogenated compounds (VOHCs), and organophosphorus compounds (OPCs) were measured in indoor and outdoor air in an industrial city, Shimizu, Shizuoka Prefecture, Japan. Levels of pollutants ten... | ['Air Pollutants', 'Air Pollution, Indoor', 'Aldehydes', 'Environmental Monitoring', 'Housing', 'Humans', 'Hydrocarbons', 'Japan', 'Organophosphorus Compounds', 'Risk Assessment'] | 16,298,419 | [['D27.888.284.101'], ['N06.850.460.100.080'], ['D02.047'], ['N06.850.460.350.080', 'N06.850.780.375'], ['J03.340', 'N01.224.791.400', 'N06.230.150.360', 'N06.850.505.400.800.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.455'], ['Z01.252.474.463', 'Z01.639.595'], ['D02.705'], ['E05.318.740.600.800.715',... | ['Chemicals and Drugs [D]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
[Myofibroblasts and afferent signalling in the urinary bladder. A concept]. | Afferent signal transduction in the urinary bladder is still not clearly understood. An increasing body of evidence supports the view of complex interactions between urothelium, suburothelial myofibroblasts, and sensory nerves. Bladder tissue from tumour patients was used in this study. Methods included confocal immuno... | ['Calcium Channels', 'Cells, Cultured', 'Fibroblasts', 'Fluorescence Recovery After Photobleaching', 'Humans', 'In Vitro Techniques', 'Microscopy, Fluorescence', 'Myoblasts, Smooth Muscle', 'Neurons, Afferent', 'Peripheral Nerves', 'Receptors, Muscarinic', 'Receptors, Purinergic', 'Sensory Receptor Cells', 'Signal Tran... | 18,679,652 | [['D12.776.157.530.400.150', 'D12.776.543.550.450.150', 'D12.776.543.585.400.150'], ['A11.251'], ['A11.329.228'], ['E05.196.712.516.600.393'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.481'], ['E01.370.350.515.458', 'E05.595.458'], ['A11.872.620.510'], ['A08.675.650', 'A11.671.650'], ['A08.800.800'], ['D12... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Production and evaluation of the utility of novel phage display-derived peptide ligands to Salmonella spp. for magnetic separation. | AIMS: The objectives of this study were to produce Salmonella-specific peptide ligands by phage display biopanning and evaluate their use for magnetic separation (MS).METHODS AND RESULTS: Four-phage display biopanning rounds were performed, and the peptides expressed by the two most Salmonella-specific (on the basis of... | ['Cell Surface Display Techniques', 'Ligands', 'Magnetic Phenomena', 'Peptides', 'Salmonella'] | 23,551,658 | [['E05.393.220.250.500', 'E05.393.420.601.292'], ['D27.720.470.480'], ['G01.358'], ['D12.644'], ['B03.440.450.425.800', 'B03.660.250.150.710']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Determination of hydrogen cyanide in cigarette mainstream smoke by LC/MS/MS. | An LC/MS/MS method is presented for the determination of hydrogen cyanide in cigarette mainstream smoke. Cyanide is derivatized with 2,3'-naphthalenedicarboxaldehyde and taurine to form a benzo[f]isoindole derivative, which is then analyzed by LC/MS/MS. Isotopic KCN (K13C15N) was used as an internal standard. The regre... | ['Chromatography, Liquid', 'Hydrogen Cyanide', 'Limit of Detection', 'Smoke', 'Tandem Mass Spectrometry', 'Tobacco'] | 20,629,410 | [['E05.196.181.400'], ['D01.029.260.330', 'D01.625.400'], ['E05.318.740.872.374', 'N05.715.360.750.725.500', 'N06.850.520.830.872.500'], ['D20.633.937'], ['E05.196.566.880'], ['B01.650.940.800.575.912.250.908.500.900']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Structural Basis for Selective Binding of Export Cargoes by Exportin-5. | In the nucleus, RanGTP binding to importin dissociates the cargo. On the other hand, RanGTP enables exportin to bind export cargo and form the export complex by each exportin's own cargo selection mechanism. Here, we present two X-ray structures for Exportin-5 (Exp-5) alone and Exp-5:RanGTP intermediate complex. The st... | ['Binding Sites', 'Crystallography, X-Ray', 'Humans', 'Karyopherins', 'Models, Molecular', 'Protein Binding', 'Protein Conformation', 'Protein Stability', 'ran GTP-Binding Protein'] | 30,100,359 | [['G02.111.570.120'], ['E05.196.309.742.225'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.157.530.750.500', 'D12.776.543.585.750.500', 'D12.776.660.502'], ['E05.599.595'], ['G02.111.679', 'G03.808'], ['G02.111.570.820.709'], ['G02.111.700'], ['D08.811.277.040.330.300.400.462', 'D12.644.360.525.462', 'D1... | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Lung cancer in young persons. | Lung cancer in patients under 40 years old is rare. Among 718 patients with lung cancer, 5% or 35 patients were younger than 40. All but one were heavy smokers. Twelve young patients who had operations survived 41.7 (SD 46.3) months: they included six who had resections of Stage 3 disease and who survived 19.2 (SD 16.0... | ['Adenocarcinoma', 'Adult', 'Age Factors', 'Carcinoma, Small Cell', 'Carcinoma, Squamous Cell', 'Female', 'Humans', 'Lung Neoplasms', 'Male', 'Sarcoma', 'Smoking'] | 6,278,230 | [['C04.557.470.200.025'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['C04.557.470.200.380'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['C04.557.450.795'], ['F01.145.805']] | ['Diseases [C]', 'Named Groups [M]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Chloride channels and alpha1-adrenoceptor-mediated pulmonary artery smooth muscle contraction: effect of pulmonary hypertension. | Noradrenaline induced concentration-dependent contractions of pulmonary artery segments from control and monocrotaline-treated rats. There was a significant decrease in the maximum response but not sensitivity in artery segments from monocrotaline-treated rats. At a concentration (10(-6) M) that abolished KCl-induced c... | ['Animals', 'Bumetanide', 'Calcium Channel Blockers', 'Chloride Channels', 'Chloride-Bicarbonate Antiporters', 'Hypertension, Pulmonary', 'Isometric Contraction', 'Male', 'Monocrotaline', 'Muscle Contraction', 'Muscle, Smooth, Vascular', 'Nifedipine', 'Niflumic Acid', 'Norepinephrine', 'Poisons', 'Pulmonary Artery', 'R... | 15,588,736 | [['B01.050'], ['D02.065.884.150', 'D02.241.223.100.050.300.200', 'D02.455.426.559.389.127.020.452.500', 'D02.886.590.700.150'], ['D27.505.519.562.249', 'D27.505.696.260.500', 'D27.505.954.411.192'], ['D12.776.157.530.400.175', 'D12.776.543.550.450.175', 'D12.776.543.585.400.175'], ['D12.776.157.530.450.162.193', 'D12.7... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytotoxicity of thermosensitive polymers poly(N-isopropylacrylamide), poly(N-vinylcaprolactam) and amphiphilically modified poly(N-vinylcaprolactam). | Thermosensitive polymers poly(N-isopropylacrylamide) (PNIPAM), poly(N-vinylcaprolactam) (PVCL) and PVCL grafted with amphiphilic poly(ethylene oxide) (PEO) chains (PVCL-graft-C11EO42) were prepared and characterized and their putative cytotoxicity was evaluated. The cytotoxicity of these thermosensitive polymers and th... | ['Acrylic Resins', 'Caco-2 Cells', 'Calorimetry, Differential Scanning', 'Caprolactam', 'Cell Line', 'Cell Line, Tumor', 'Cell Survival', 'Chromatography', 'Coloring Agents', 'Dose-Response Relationship, Drug', 'Hot Temperature', 'Humans', 'L-Lactate Dehydrogenase', 'Light', 'Models, Chemical', 'Polyethylene Glycols', ... | 15,603,800 | [['D05.750.716.822.111', 'D25.720.716.822.111', 'J01.637.051.720.716.822.111'], ['A11.251.210.190.160', 'A11.251.860.180.160', 'A11.436.140'], ['E05.196.131.310', 'E05.196.370.310'], ['D02.065.589.200', 'D03.383.066.150', 'D03.383.411.200'], ['A11.251.210'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.346'], ['E05.19... | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Abiotic factors determine functional outcomes of microbial inoculation of soils from a metal contaminated brownfield. | Whole community microbial inoculation can improve soil function in contaminated environments. Here we conducted a case study to investigate whether biotic factors (inoculum) or abiotic factors (soil base) have more impact on the extracellular enzymatic activities in a whole community microbial inoculation. To this end,... | ['Agricultural Inoculants', 'Biodegradation, Environmental', 'Chemical Phenomena', 'Metals, Heavy', 'Phosphoric Monoester Hydrolases', 'RNA, Ribosomal, 16S', 'Soil', 'Soil Microbiology', 'Soil Pollutants'] | 30,415,167 | [['B01.300.053', 'B03.054'], ['N06.230.080.600.500', 'N06.850.460.375.500'], ['G02'], ['D01.268.556', 'D01.552.544'], ['D08.811.277.352.650'], ['D13.444.735.686.670'], ['D20.721', 'G01.311.820', 'G16.500.275.815', 'N06.230.600'], ['H01.158.273.540.274.555', 'N06.850.425.300'], ['D27.888.284.756']] | ['Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Neurophysiological changes with age probed by inverse modeling of EEG spectra. | OBJECTIVE: To investigate age-associated changes in physiologically-based EEG spectral parameters in the healthy population.METHODS: Eyes-closed EEG spectra of 1498 healthy subjects aged 6-86 years were fitted to a mean-field model of thalamocortical dynamics in a cross-sectional study. Parameters were synaptodendritic... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Aging', 'Axons', 'Cerebral Cortex', 'Child', 'Cross-Sectional Studies', 'Dendrites', 'Electroencephalography', 'Female', 'Humans', 'Male', 'Middle Aged', 'Models, Neurological', 'Sex Factors', 'Thalamus', 'Time Factors', 'Young Adult'] | 19,854,102 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['G07.345.124'], ['A08.675.542.145', 'A11.284.180.075', 'A11.671.137', 'A11.671.501.145'], ['A08.186.211.200.885.287.500'], ['M01.060.406'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['A08.675.256', 'A1... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Visualization of giant virus particles and development of "VIRAMOS" for high school and university biology course. | Several educational trials on handling viruses and or virology have been reported. However, given their small size, direct visualization of these viruses under a microscope has been rarely performed. The so-called "giant viruses" are larger than other viruses with a particle size greater than 200-300 nm. This enables t... | ['Biology', 'Data Visualization', 'Giant Viruses', 'Humans', 'Learning', 'Microscopy', 'Students', 'Teaching', 'Universities', 'Virion'] | 31,021,444 | [['H01.158.273'], ['L01.143.288'], ['B04.280.356'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.425', 'F02.784.629.529'], ['E01.370.350.515', 'E05.595', 'H01.671.617.562'], ['M01.848'], ['I02.903'], ['I02.783.830', 'J03.832.830'], ['A21.249']] | ['Disciplines and Occupations [H]', 'Information Science [L]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Technology, Industry, and Agriculture [J]', 'Anato... | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
Formaldehyde cross-linking for studying nucleosomal dynamics. | Methods are described for the utilization of formaldehyde as a reversible cross-linking agent for the characterization of protein-protein and protein-DNA interactions. The methods include a description of procedures to: (1) isolate and characterize transcriptionally active chromatin from cells cross-linked with formald... | ['Cross-Linking Reagents', 'Electrophoresis, Polyacrylamide Gel', 'Formaldehyde', 'Histones', 'Hydrogen-Ion Concentration', 'Magnesium', 'Molecular Biology', 'Nucleosomes', 'Ribonuclease, Pancreatic', 'Sonication', 'Time Factors'] | 10,075,891 | [['D27.720.470.410.210'], ['E05.196.401.402', 'E05.301.300.319'], ['D02.047.407'], ['D12.776.157.687.485', 'D12.776.660.720.485', 'D12.776.664.469'], ['G02.300'], ['D01.268.552.437', 'D01.268.557.500', 'D01.552.547.500'], ['H01.158.201.636', 'H01.158.273.343.595', 'H01.181.122.650'], ['A11.284.430.106.279.345.190.160.1... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Anatomy [A]'] | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
High glucose suppresses human islet insulin biosynthesis by inducing miR-133a leading to decreased polypyrimidine tract binding protein-expression. | BACKGROUND: Prolonged periods of high glucose exposure results in human islet dysfunction in vitro. The underlying mechanisms behind this effect of high glucose are, however, unknown. The polypyrimidine tract binding protein (PTB) is required for stabilization of insulin mRNA and the PTB mRNA 3'-UTR contains binding si... | ['Cytokines', 'Gene Expression Regulation', 'Glucose', 'Humans', 'Insulin', 'Islets of Langerhans', 'MicroRNAs', 'Palmitic Acid', 'Polypyrimidine Tract-Binding Protein', 'RNA Precursors', 'RNA, Messenger'] | 20,520,763 | [['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['G05.308'], ['D09.947.875.359.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D06.472.699.587.200.500.625', 'D12.644.548.586.200.500.625'], ['A03.734.414', 'A06.300.414'], ['D13.150.650.319', 'D13.444.735.150.319', 'D13.444.735.790.552.500'], ['D10.251.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
THUMP: an immersive haptic console for surgical simulation and training. | Telerobotic systems are revolutionizing minimally invasive surgery (MIS), giving the surgeon complete control over precise dexterous movements of tiny robotic instruments. Such 'surgery-by-wire' approaches also create unique opportunities for simulation and training, as the surgeon operates at a computer-mediated hapti... | ['Computer Simulation', 'General Surgery', 'Robotics', 'United States', 'User-Computer Interface'] | 15,544,287 | [['L01.224.160'], ['H02.403.810.300'], ['H01.671.293.643', 'J01.897.104.834', 'L01.224.050.375.630'], ['Z01.107.567.875'], ['L01.224.900.910']] | ['Information Science [L]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Geographicals [Z]'] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 |
Effects of selective angiotensin II type 1 receptor blockade with losartan on arterial compliance in patients with mild essential hypertension. | It has been suggested that antihypertensive drugs should not only decrease blood pressure, but also improve large artery compliance. The aim of the present study was to examine the effect of losartan, a selective angiotensin II type 1 receptor antagonist, on parameters reflecting arterial compliance. In a randomized, d... | ['Adult', 'Aged', 'Analysis of Variance', 'Angiotensin Receptor Antagonists', 'Antihypertensive Agents', 'Arteries', 'Blood Pressure', 'Cardiac Output', 'Cross-Over Studies', 'Double-Blind Method', 'Heart Rate', 'Hemodynamics', 'Humans', 'Losartan', 'Middle Aged', 'Plethysmography', 'Pulsatile Flow', 'Receptor, Angiote... | 10,697,301 | [['M01.060.116'], ['M01.060.116.100'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['D27.505.519.162'], ['D27.505.954.411.162'], ['A07.015.114'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E01.370.370.380.150', 'G09.330.380.124'], ['E05.318.370.150', 'N05.715.360.325.150', 'N06.850.520.445.150... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Fasting and postprandial antroduodenal motility in functional dyspepsia]. | Fasting and postprandial antroduodenal motility was studied with manometry in 39 patients with functional dyspepsia (FD) and 15 healthy volunteers. The results showed that: (1) the interdigestive antral motility was significantly decreased with contractions of lower amplitude and less frequency and the amplitude of duo... | ['Adolescent', 'Adult', 'Duodenum', 'Dyspepsia', 'Fasting', 'Female', 'Gastrointestinal Motility', 'Humans', 'Male', 'Manometry', 'Middle Aged', 'Pyloric Antrum'] | 8,697,913 | [['M01.060.057'], ['M01.060.116'], ['A03.556.124.684.124', 'A03.556.875.249'], ['C23.888.821.236'], ['F01.145.407.400', 'G07.203.650.240.587', 'G07.203.650.353.400'], ['G10.261.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.559'], ['M01.060.116.630'], ['A03.556.875.875.716']] | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Characterization of the effector cells responsible for tumour resistance in Salmonella enteritidis 11RX-immunized mice. | In an attempt to characterize the effector cells responsible for tumour resistance in Salmonella enteritidis 11RX-immunized mice the anti-macrophage agent trypan blue was used in both in vivo and in vitro experiments. Resistance was measured in vivo by the clearance of 125I from the peritoneal cavity of mice injected i... | ['Animals', 'Carcinoma, Ehrlich Tumor', 'Cell Communication', 'Cell Separation', 'Cytotoxicity, Immunologic', 'Immunity, Innate', 'Immunization', 'Killer Cells, Natural', 'Macrophages', 'Mice', 'Salmonella enteritidis', 'Trypan Blue'] | 7,046,716 | [['B01.050'], ['C04.557.470.200.200', 'C04.619.169'], ['G04.085'], ['E01.370.225.500.363', 'E05.200.500.363', 'E05.242.363'], ['G12.287'], ['G12.450.564'], ['E02.095.465.425.400', 'E05.478.550', 'N02.421.726.758.310', 'N06.850.780.200.425', 'N06.850.780.680.310'], ['A11.118.637.555.567.537', 'A15.145.229.637.555.567.53... | ['Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[The interaction between gamma-aminobutyric acid and other related neurotransmitters in depression]. | Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter of the central nervous system (CNS) in mammalian, which involved in several mood disorders such as anxiety, depression and schizophrenia. Nowadays, there are growing evidences showed that the depression is concerned with a deficiency in brain GABA.... | ['Animals', 'Brain', 'Depression', 'Dopamine', 'Glutamic Acid', 'Humans', 'Neurotransmitter Agents', 'Serotonin', 'gamma-Aminobutyric Acid'] | 25,219,270 | [['B01.050'], ['A08.186.211'], ['F01.145.126.350'], ['D02.092.211.215.406', 'D02.092.311.342', 'D02.455.426.559.389.657.166.175.342'], ['D12.125.067.625.349', 'D12.125.119.409.349', 'D12.125.427.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.519.625', 'D27.505.696.577'], ['D02.092.211.215.801.852', '... | ['Organisms [B]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The curvature vector in nucleosomal DNAs and theoretical prediction of nucleosome positioning. | Using our model for predicting DNA superstructures from the sequence, the average distribution of the phases of curvature along the sequences of the set of the 177 nucleosomal DNAs investigated by Satchwell et al. (J. Mol. Biol. 191 (1986) 659) was calculated. The diagram obtained shows very significant features which ... | ['Base Sequence', 'Chemical Phenomena', 'Chemistry, Physical', 'DNA', 'DNA, Viral', 'Genes, Regulator', 'Genes, Viral', 'Models, Chemical', 'Nucleic Acid Conformation', 'Nucleosomes', 'Simian virus 40'] | 1,647,823 | [['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G02'], ['H01.181.529'], ['D13.444.308'], ['D13.444.308.568'], ['G05.360.340.024.340.425'], ['G05.360.340.024.340.364.875', 'G05.360.340.358.024.875', 'G05.360.340.358.840.500'], ['E05.599.495'], ['G02.111.570.820.486', 'G05.360.580'], ['A11.284.430.106.279.3... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Melampodium leucanthum, a source of cytotoxic sesquiterpenes with antimitotic activities. | A new tricyclic sesquiterpene, named meleucanthin (1), was isolated from an extract of the leaves and branches of Melampodium leucanthum, along with four known germacranolide sesquiterpene lactones, leucanthin-A (2), leucanthin-B (3), melampodin-A acetate (4), and 3á-hydroxyenhydrin (5). The chemical structure of 1 was... | ['Antimitotic Agents', 'Antineoplastic Agents, Phytogenic', 'Asteraceae', 'Cell Cycle', 'Drug Screening Assays, Antitumor', 'Female', 'HeLa Cells', 'Humans', 'Molecular Structure', 'Nuclear Magnetic Resonance, Biomolecular', 'Sesquiterpenes', 'Texas'] | 25,685,941 | [['D27.505.519.593.249', 'D27.505.954.248.147'], ['D27.505.954.248.179'], ['B01.650.940.800.575.912.250.100'], ['G04.144'], ['E01.370.225.500.388', 'E05.200.500.388', 'E05.242.417', 'E05.337.550.200'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Geographicals [Z]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
[Abdominal actinomycosis: four cases]. | The abdominal actinomycosis (AA) is a rare and often unrecognised suppurative chronic illness. It is caused by an anaerobic Gram positive bacteria, Actinomyces israelii. Abdominal actinomycosis is responsible for pseudotumoral syndrome often leading, to a large and mutilating surgery whereas a prolonged treatment by an... | ['Abdominal Abscess', 'Abdominal Wall', 'Actinomyces', 'Actinomycosis', 'Aged', 'Anti-Bacterial Agents', 'Cholecystectomy', 'Female', 'Humans', 'Intrauterine Devices', 'Middle Aged', 'Pelvic Inflammatory Disease', 'Rectus Abdominis', 'Round Ligament of Uterus', 'Treatment Outcome'] | 19,180,833 | [['C01.830.025.020'], ['A01.923.047.050'], ['B03.510.024.049.050.050', 'B03.510.460.400.400.049.049.178'], ['C01.150.252.410.040.137'], ['M01.060.116.100'], ['D27.505.954.122.085'], ['E04.210.120.172'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E07.190.250.510'], ['M01.060.116.630'], ['C01.635.500', 'C13.351.5... | ['Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Association of the frequency of spicy food intake and the risk of abdominal obesity in rural Chinese adults: a cross-sectional study. | OBJECTIVES: Recent data relating to the association between spicy food intake frequency and abdominal obesity are limited, especially in low-income areas. Therefore, the study explored the relationship between spicy food intake frequency and abdominal obesity, and assessed the role of energy intake as a mediator of the... | ['Adult', 'Aged', 'Body Mass Index', 'China', 'Cohort Studies', 'Cross-Sectional Studies', 'Diet', 'Female', 'Flavoring Agents', 'Food Preferences', 'Humans', 'Logistic Models', 'Male', 'Middle Aged', 'Obesity, Abdominal', 'Prevalence', 'Risk Assessment', 'Risk Factors', 'Rural Health', 'Spices', 'Taste'] | 31,712,332 | [['M01.060.116'], ['M01.060.116.100'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['Z01.252.474.164'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['G07.20... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Geographicals [Z]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
Increase in bicarbonate stores with exercise. | We previously described bicarbonate exchange dynamics in humans at rest and during exercise using a three-compartment model. In the present study we tested the effect of certain assumptions of this model on the prediction of the change in exchangeable bicarbonate with the increased metabolic rate of exercise. We compar... | ['Bicarbonates', 'Cardiac Output', 'Exercise', 'Humans', 'Models, Biological', 'Oxygen Consumption', 'Rest', 'Time Factors', 'Veins'] | 1,565,895 | [['D01.200.275.150.100', 'D01.248.497.158.165.100'], ['E01.370.370.380.150', 'G09.330.380.124'], ['G11.427.410.698.277', 'I03.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.395'], ['G03.680'], ['I03.450.769.647'], ['G01.910.857'], ['A07.015.908']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
Intravenous magnesium sulfate for the treatment of acute asthma in the emergency department. | Conventional nebulized beta-agonist therapy has met with disappointing results in an increasing number of moderate to severe asthmatics who may be characterized as "poor responders." Thirty-eight patients suffering from acute exacerbations of moderate to severe asthma were treated in an emergency department with an int... | ['Adolescent', 'Adult', 'Aged', 'Asthma', 'Double-Blind Method', 'Emergency Service, Hospital', 'Female', 'Humans', 'Infusions, Intravenous', 'Magnesium Sulfate', 'Male', 'Middle Aged', 'Patient Admission', 'Patient Discharge', 'Peak Expiratory Flow Rate', 'Random Allocation'] | 2,761,061 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['N02.278.216.500.968.336', 'N02.421.297.195', 'N04.452.442.452.422.336'], ['B01.050.150.900.649.313.988... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Maternal Perception of Adequacy of Mother's Milk Among Mothers Giving Birth at a Teaching Hospital in Sri Lanka. | BACKGROUND:: Sri Lanka boasts high rates of early and exclusive breastfeeding. Perceived inadequacy of milk, a global problem, is the main cause for early cessation of breastfeeding.RESEARCH AIMS:: The aims of this study are to (a) determine the prevalence, (b) identify the risk factors, and (c) ascertain the associati... | ['Adolescent', 'Adult', 'Breast Feeding', 'Cross-Sectional Studies', 'Female', 'Hospitals, Teaching', 'Humans', 'Lactation', 'Milk, Human', 'Mothers', 'Perception', 'Pregnancy', 'Prospective Studies', 'Sri Lanka', 'Surveys and Questionnaires', 'Young Adult'] | 29,787,682 | [['M01.060.057'], ['M01.060.116'], ['F01.145.407.199', 'G07.203.650.195', 'G07.203.650.220.500.500', 'G07.203.650.353.199'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['N02.278.020.300', 'N02.278.421.639'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G08.686.523', 'G08.686.70... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Ge... | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
Abundance, distribution and size structure of Diadema antillarum (Echinodermata: Diadematidae) in South Eastern Cuban coral reefs. | The 1983-1984 mass mortality event of Diadema antillarum affected more than 93% of the total Caribbean population. Although there are no records about the status of Diadema populations before and after die-off on Cuban reefs, anecdotal information suggests that populations were struck. We analyzed spatial variation in ... | ['Animals', 'Anthozoa', 'Cuba', 'Echinodermata', 'Population Density', 'Population Dynamics', 'Sea Urchins', 'Seasons'] | 20,527,467 | [['B01.050'], ['B01.050.500.308.237'], ['Z01.107.084.900.225', 'Z01.639.880.225'], ['B01.050.500.408'], ['N01.224.600', 'N06.850.505.400.600'], ['I01.240.600', 'N01.224.625', 'N06.850.505.400.700'], ['B01.050.500.408.578'], ['G01.910.645.661', 'G16.500.275.071.590', 'N06.230.300.100.250.525']] | ['Organisms [B]', 'Geographicals [Z]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
[Benign pre-sacral teratoma and vestigial retrorectal cysts in the adult]. | Benign mature presacral teratomas or dermoid cysts occur rarely in the adult; the incidence is estimated at less than 1/40,000. They are considered to be retrorectal vestigial growths from embryonal rests; they are usually asymptomatic and discovered by chance. However, since they have a 20-30% risk of secondary infect... | ['Dermoid Cyst', 'Humans', 'Male', 'Middle Aged', 'Rectal Neoplasms', 'Sacrococcygeal Region', 'Soft Tissue Neoplasms', 'Teratoma'] | 17,185,960 | [['C04.182.201', 'C04.557.465.910.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C04.588.274.476.411.307.790', 'C06.301.371.411.307.790', 'C06.405.249.411.307.790', 'C06.405.469.491.307.790', 'C06.405.469.860.180.500'], ['A01.923.176.780'], ['C04.588.839'], ['C04.557.465.910']] | ['Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Renal Artery Aneurysm A Neverland Entity. | Renal artery aneurysms are rare. The indication for treatment at 20mm diameter comes from studies conducted before the advent of cross-sectional imaging. We present a case of a 61years-old woman with a 23mm saccular right renal artery aneurysm under surveillance for 6 years without growing. | ['Aneurysm', 'Female', 'Humans', 'Middle Aged', 'Renal Artery'] | 32,707,625 | [['C14.907.055'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['A07.015.114.745']] | ['Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Cardiac excitation-contraction coupling is altered in myocytes from aged male mice but not in cells from aged female mice. | This study characterized age-related alterations in excitation-contraction (EC)-coupling in ventricular myocytes and investigated whether these alterations are affected by the sex of the animal. Voltage-clamp experiments were conducted in myocytes from young adult (approximately 7 mo) and aged (approximately 24 mo) mal... | ['Aging', 'Animals', 'Calcium', 'Electric Conductivity', 'Electric Stimulation', 'Female', 'Fluorescent Dyes', 'Fura-2', 'Heart Ventricles', 'Male', 'Mice', 'Mice, Inbred Strains', 'Myocardial Contraction', 'Myocytes, Cardiac', 'Patch-Clamp Techniques', 'Sarcoplasmic Reticulum'] | 16,731,653 | [['G07.345.124'], ['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['G01.358.500.249.277'], ['E05.723.402'], ['D27.720.233.348', 'D27.720.470.410.505.500'], ['D03.383.129.462.285', 'D03.633.100.127.250'], ['A07.541.560'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520', 'B01.0... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Induction of Syndecan-4 by Organic-Inorganic Hybrid Molecules with a 1,10-Phenanthroline Structure in Cultured Vascular Endothelial Cells. | Organic-inorganic hybrid molecules constitute analytical tools used in biological systems. Vascular endothelial cells synthesize and secrete proteoglycans, which are macromolecules consisting of a core protein and glycosaminoglycan side chains. Although the expression of endothelial proteoglycans is regulated by severa... | ['Animals', 'Aorta', 'Cattle', 'Cells, Cultured', 'Endothelial Cells', 'Enzyme Activation', 'Hypoxia-Inducible Factor 1, alpha Subunit', 'Hypoxia-Inducible Factor-Proline Dioxygenases', 'Phenanthrolines', 'Proteoglycans', 'Signal Transduction', 'Syndecan-4'] | 28,208,699 | [['B01.050'], ['A07.015.114.056'], ['B01.050.150.900.649.313.500.380.271'], ['A11.251'], ['A11.436.275'], ['G02.111.263', 'G03.328'], ['D12.776.260.103.625.750', 'D12.776.930.125.625.750'], ['D08.811.682.690.416.617.500', 'D08.811.682.690.708.694.500'], ['D03.633.300.669'], ['D09.698.735', 'D12.776.395.650'], ['G02.111... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Understanding the pathophysiology of hyperglycemia-associated chorea-ballism: a systematic review of positron emission tomography findings. | Hyperglycemia-associated chorea-ballism (HCB) is an infrequent neurological syndrome whose pathophysiology remains poorly understood. Positron emission tomography (PET) studies have offered valuable information regarding regional glucose metabolism. The studies included were published between 1980-2017 and reported dem... | ['Basal Ganglia', 'Chorea', 'Humans', 'Hyperglycemia', 'Motor Cortex', 'Positron-Emission Tomography'] | 29,984,683 | [['A08.186.211.200.885.287.249'], ['C10.228.662.262.249', 'C10.597.350.250', 'C23.888.592.350.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C18.452.394.952'], ['A08.186.211.200.885.287.500.270.548', 'A08.186.211.200.885.287.500.814.624'], ['E01.370.350.350.800.700', 'E01.370.350.600.350.800.399', 'E01.370.3... | ['Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Craniofacial parameters during growth from the deciduous to permanent dentition--a longitudinal study. | Data on the dynamics of craniofacial growth, obtained by simple non-invasive measurements, are scarce in comparison with those collected by cephalometric methods. The aim of this study was to measure a number of craniofacial parameters, and to evaluate their changes during transition from the deciduous to the permanent... | ['Anthropometry', 'Cephalometry', 'Child', 'Child, Preschool', 'Chin', 'Dentition, Mixed', 'Dentition, Permanent', 'Evaluation Studies as Topic', 'Facial Bones', 'Female', 'Humans', 'Longitudinal Studies', 'Male', 'Mandible', 'Maxilla', 'Nasal Bone', 'Regression Analysis', 'Sex Characteristics', 'Skull', 'Tooth, Decidu... | 9,458,601 | [['E01.370.600.024', 'E05.041', 'N06.850.505.200.100'], ['E01.370.600.024.250', 'E05.041.250', 'N06.850.505.200.100.300'], ['M01.060.406'], ['M01.060.406.448'], ['A01.456.505.259', 'A02.835.232.781.324.502.632.130', 'A14.521.632.300'], ['A14.549.167.229'], ['A14.549.167.237'], ['E05.337', 'N05.715.360.335'], ['A02.835.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Cervical stromal invasion predicting survival in endometrial cancer. | OBJECTIVE: To estimate the extent to which cervical stromal invasion would predict survival.METHODS: Cases of stage II endometrioid endometrial adenocarcinoma from three academic institutions were reviewed. A gynecologic pathologist reevaluated archived slides and measured the depth of cervical stromal invasion. Clinic... | ['Adult', 'Aged', 'Aged, 80 and over', 'Carcinoma, Endometrioid', 'Cervix Uteri', 'Endometrial Neoplasms', 'Female', 'Humans', 'Middle Aged', 'Neoplasm Invasiveness', 'Survival Rate'] | 20,966,686 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C04.557.470.200.025.240', 'C04.588.945.418.948.585.124', 'C13.351.500.056.630.705.331', 'C13.351.937.418.685.331', 'C13.351.937.418.875.200.124', 'C19.391.630.705.331'], ['A05.360.319.679.256'], ['C04.588.945.418.948.585', 'C13.351.500.852.762.200', 'C13... | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Cardiovascular effects of 1,8-cineole, a terpenoid oxide present in many plant essential oils, in normotensive rats. | The cardiovascular effects of i.v. treatment with 1,8-cineole, a monoterpenic oxide present in many plant essential oils, were investigated in normotensive rats. This study examined (i) whether the autonomic nervous system is involved in the mediation of 1,8-cineole-induced changes in mean aortic pressure (MAP) and hea... | ['Animals', 'Blood Pressure', 'Cardiovascular System', 'Cyclohexanols', 'Dose-Response Relationship, Drug', 'Eucalyptol', 'Male', 'Monoterpenes', 'Oils, Volatile', 'Oxides', 'Rats', 'Rats, Wistar', 'Terpenes', 'Vasodilation'] | 12,564,637 | [['B01.050'], ['E01.370.600.875.249', 'G09.330.380.076'], ['A07'], ['D02.033.415.510.500', 'D02.455.426.392.368.367.318', 'D10.289.510.500'], ['G07.690.773.875', 'G07.690.936.500'], ['D02.033.415.510.500.454', 'D02.455.426.392.368.367.318.625', 'D02.455.849.575.250', 'D10.289.510.500.454'], ['D02.455.849.575'], ['D10.6... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Stereotypic and hypothermic effects of apomorphine and N-n-propylnorapomorphine in mice. | Two dopaminergic agonists, apomorphine (APO) and N-n-propylnorapomorphine (NPA) were compared in mice for their ability to induce stereotypic cage-climbing and hypothermia. Stereotypic cage-climbing responses were recorded on videotape and subsequently rated "blind" in comparison to the animal's predrug behavior and to... | ['Animals', 'Apomorphine', 'Behavior', 'Body Temperature', 'Humans', 'Male', 'Mice', 'Stereotyped Behavior'] | 570,924 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Stability in cyclic epidemic models. | A general formulation for a family of cyclic epidemic models with density-dependent feedback mechanisms and removed classes is presented. A parameter, lambda, related to the basic reproductive rate determines the asymptotic behaviour of solutions of the model. It is shown that if lambda less than 1 the trivial solution... | ['Animals', 'Biometry', 'Epidemiology', 'Humans', 'Models, Biological', 'Parasites', 'Population Dynamics'] | 4,067,441 | [['B01.050'], ['E05.318.740.225', 'N06.850.505.200'], ['H02.403.720.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.395'], ['B01.050.500.714'], ['I01.240.600', 'N01.224.625', 'N06.850.505.400.700']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 |
Platelet-derived growth factor receptor-mediated signal transduction from endosomes. | Although accumulated evidence supports the concept of endosomal signaling of receptor tyrosine kinases, most results are generated from studies of epidermal growth factor receptor (EGFR). It is not clear whether the concept of endosomal signaling could be generally applied to the other receptor tyrosine kinases. For ex... | ['Adaptor Proteins, Signal Transducing', 'Adaptor Proteins, Vesicular Transport', 'Adipocytes', 'Animals', 'Carcinoma, Hepatocellular', 'Cell Division', 'Cell Line', 'Cell Membrane', 'Cell Survival', 'Endosomes', 'ErbB Receptors', 'Fluorescent Antibody Technique', 'GRB2 Adaptor Protein', 'Humans', 'Liver Neoplasms', 'M... | 14,660,565 | [['D12.644.360.024', 'D12.776.157.057', 'D12.776.476.024'], ['D12.776.543.990.150'], ['A11.329.114'], ['B01.050'], ['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['A11.251.210'], ['A11.284.149'], ['G04.3... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The isolated perfused liver response to a 'second hit' of portal endotoxin during severe acute pancreatitis. | BACKGROUND/AIM: During severe acute pancreatitis (AP), the liver may show an exaggerated response to the inflammatory products of gut injury transported in the portal vein. Our aim was to explore liver proinflammatory mediator production after a 'second hit' of portal lipopolysaccharide (LPS) during AP.METHODS: Twenty-... | ['Amylases', 'Animals', 'Animals, Outbred Strains', 'Ceruletide', 'Disease Models, Animal', 'Glycodeoxycholic Acid', 'Interleukin-6', 'Lipopolysaccharides', 'Liver', 'Male', 'Neutrophil Activation', 'Neutrophils', 'Pancreas', 'Pancreatitis, Acute Necrotizing', 'Perfusion', 'Rats', 'Rats, Wistar', 'Respiratory Burst', '... | 15,985,775 | [['D08.811.277.450.066'], ['B01.050'], ['B01.050.050.284'], ['D12.644.456.241'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['D04.210.500.105.225.272.411', 'D04.210.500.105.225.400.380', 'D04.210.500.221.430.342.400', 'D04.210.500.221.430.484.430', 'D12.125.481.700.249.420'], ['D12.644.276.374.465.224', 'D12.776.46... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Antibody reactivity to linear epitopes of Plasmodium falciparum cytoadherence-linked asexual gene 9 in asymptomatic children and adults from papua new Guinea. | The cytoadherence-linked asexual gene 9 (clag 9) of Plasmodium falciparum has been implicated in the cytoadherence of infected erythrocytes. To determine the immunogenicity of the clag 9 gene product (CLAG 9 protein) in humans, we measured antibody responses to 11 synthetic CLAG 9 peptides in a group of 177 asymptomati... | ['Adult', 'Amino Acid Sequence', 'Animals', 'Antibodies, Protozoan', 'Cell Adhesion', 'Cell Adhesion Molecules', 'Child', 'Genes, Protozoan', 'Humans', 'Molecular Sequence Data', 'New Guinea', 'Plasmodium falciparum', 'Protozoan Proteins', 'Sequence Homology, Amino Acid'] | 15,964,954 | [['M01.060.116'], ['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D12.776.124.486.485.114.252', 'D12.776.124.790.651.114.252', 'D12.776.377.715.548.114.252'], ['G04.022'], ['D12.776.395.550.200', 'D12.776.543.550.200', 'D23.050.301.350'], ['M01.060.406'], ['G05.360.340.024.340.396', 'G05.360.340.397.500'], [... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Geographicals [Z]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 |
Evaluation of diversity among common beans (Phaseolus vulgaris L.) from two centers of domestication using 'omics' technologies. | BACKGROUND: Genetic diversity among wild accessions and cultivars of common bean (Phaseolus vulgaris L.) has been characterized using plant morphology, seed protein allozymes, random amplified polymorphic DNA, restriction fragment length polymorphisms, DNA sequence analysis, chloroplast DNA, and microsatellite markers.... | ['Crops, Agricultural', 'Gene Expression Profiling', 'Gene Expression Regulation, Plant', 'Genetic Variation', 'Genomics', 'Metabolomics', 'Oligonucleotide Array Sequence Analysis', 'Phaseolus', 'Phylogeny', 'Proteomics'] | 21,126,341 | [['B01.650.160', 'G07.203.300.300', 'J02.500.300'], ['E05.393.332'], ['G05.308.375'], ['G05.365'], ['H01.158.273.180.350', 'H01.158.273.343.350'], ['H01.158.201.586', 'H01.158.273.180.599', 'H01.181.122.638'], ['E05.393.661.640', 'E05.393.760.640', 'E05.588.570.660', 'E05.601.640'], ['B01.650.940.800.575.912.250.401.64... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 |
Risk of hepatitis B in adolescence and young adulthood. | In countries of low hepatitis B virus (HBV) endemicity, infection occurs mainly in adolescents and young adults (15-34 years old). The most important risk factors for infection are heterosexual activity, homosexual activity and intravenous drug use. In industrialized countries, therefore, HBV infection is classified am... | ['Adolescent', 'Adult', 'Age Factors', 'Hepatitis B', 'Humans', 'Incidence', 'Prevalence', 'Risk Factors'] | 7,571,824 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['C01.221.250.500', 'C01.925.256.430.400', 'C01.925.440.435', 'C06.552.380.705.437'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.985.525.375... | ['Named Groups [M]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Serum leptin levels positively correlate with peripheral arterial stiffness in kidney transplantation patients. | BACKGROUND: Leptin is a protein predominantly produced by adipocytes that plays a pathophysiologic role in the pathogenesis of hypertension and cardiovascular diseases. The aim of this study was to evaluate the relationship between fasting serum leptin levels and peripheral arterial stiffness among kidney transplant (K... | ['Adult', 'Aged', 'Female', 'Humans', 'Kidney Transplantation', 'Leptin', 'Male', 'Middle Aged', 'Vascular Stiffness'] | 24,655,962 | [['M01.060.116'], ['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.870.500', 'E04.936.450.485', 'E04.950.774.400'], ['D06.472.699.042.500', 'D12.644.276.024.500', 'D12.644.548.011.500', 'D12.776.467.024.500', 'D23.529.024.500'], ['M01.060.116.630'], ['G09.330.940']] | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder. | Autism spectrum disorder (ASD) is a highly heritable disorder of complex and heterogeneous aetiology. It is primarily characterized by altered cognitive ability including impaired language and communication skills and fundamental deficits in social reciprocity. Despite some notable successes in neuropsychiatric genetic... | ['Adult', 'Child', 'Child Development Disorders, Pervasive', 'Cluster Analysis', 'Cohort Studies', 'DNA Copy Number Variations', 'Female', 'Genetic Predisposition to Disease', 'Genome-Wide Association Study', 'Genotype', 'Haplotypes', 'Homozygote', 'Humans', 'Linkage Disequilibrium', 'Male', 'Middle Aged', 'Nuclear Fam... | 21,996,756 | [['M01.060.116'], ['M01.060.406'], ['F03.625.164'], ['E05.318.740.250', 'N05.715.360.750.200', 'N06.850.520.830.250'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['G05.365.795.297.500'], ['C23.550.291.687.500', 'G05.380.355'], ['E05.318.370.392', 'E05.318.416.249', 'E05.393.385.500',... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Estrogen receptor gene polymorphism and craniofacial morphology in female TMJ osteoarthritis patients. | The aim of this study was to investigate the possible influence of estrogen receptor alpha (ERalpha) polymorphism on the craniofacial skeleton in female patients suffering from symptomatic osteoarthritis (OA) of the temporomandibular joint (TMJ). The sample comprised 76 genetically unrelated Korean women diagnosed with... | ['Adolescent', 'Adult', 'Cephalometry', 'Chi-Square Distribution', 'Estrogen Receptor alpha', 'Female', 'Humans', 'Mandible', 'Middle Aged', 'Osteoarthritis', 'Polymorphism, Genetic', 'Radiography', 'Skull', 'Statistics, Nonparametric', 'Temporomandibular Joint Disorders'] | 16,154,319 | [['M01.060.057'], ['M01.060.116'], ['E01.370.600.024.250', 'E05.041.250', 'N06.850.505.200.100.300'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['D12.776.826.750.350.174'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.232.781.324.502.632', 'A14.521.632']... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Malignant solitary fibrous tumor of the lumbar spinal root mimicking schwannoma: a case report. | BACKGROUND CONTEXT: Malignant solitary fibrous tumors (SFTs) arising from the spinal cord are extremely rare and poorly understood mesenchymal neoplasms. To date, only one malignant SFT located in the spinal canal of the sacrum has been described, but none arising from the lumbar nerve root have been reported. Although... | ['Diagnosis, Differential', 'Female', 'Humans', 'Magnetic Resonance Imaging', 'Middle Aged', 'Neurilemmoma', 'Peripheral Nervous System Neoplasms', 'Solitary Fibrous Tumors', 'Spinal Nerve Roots'] | 24,120,147 | [['E01.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['M01.060.116.630'], ['C04.557.465.625.650.595', 'C04.557.580.600.610.595', 'C04.557.580.625.650.595'], ['C04.588.614.596', 'C10.551.775', 'C10.668.829.725'], ['C04.557.450.565.590.797'], ['A08.800.800.720.725']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Global macroevolution and macroecology of passerine song. | Studying the macroevolution of the songs of Passeriformes (perching birds) has proved challenging. The complexity of the task stems not just from the macroevolutionary and macroecological challenge of modeling so many species, but also from the difficulty in collecting and quantifying birdsong itself. Using machine lea... | ['Animal Communication', 'Animal Distribution', 'Animals', 'Biological Evolution', 'Life History Traits', 'Mating Preference, Animal', 'Passeriformes', 'Spatio-Temporal Analysis'] | 29,441,527 | [['F01.145.113.055'], ['F01.145.113.069', 'G16.049'], ['B01.050'], ['G05.045', 'G16.075'], ['G05.045.513', 'G16.575'], ['F01.145.113.252.748.300'], ['B01.050.150.900.248.620'], ['E05.318.740.933.500', 'N05.715.360.750.746.500', 'N06.850.520.830.933.500']] | ['Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Transventricular mitral valve replacement in a patient with a left ventricular aneurysm: report of a case. | Postinfarct left ventricular aneurysm associated with mitral valve regurgitation is resistant to medical treatment and often requires surgical repair. A transventricular approach to the mitral valve in such a patient can enable the surgeon to avoid incision of the right or left atrium, and can provide for safe and reli... | ['Coronary Aneurysm', 'Female', 'Heart Valve Prosthesis Implantation', 'Humans', 'Middle Aged', 'Mitral Valve', 'Mitral Valve Insufficiency'] | 9,681,620 | [['C14.280.647.250.250', 'C14.907.055.395', 'C14.907.585.250.250'], ['E04.100.376.485', 'E04.650.410', 'E04.928.220.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['A07.541.510.507'], ['C14.280.484.461']] | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
CT evaluation of an anterior urethral tear. | A retrograde urethrogram is usually performed to evaluate the urethra in patients with suspected urethral injuries. A computed tomography (CT) scan is performed after the retrograde urethrogram to evaluate for further intrabdominal injuries. We present a case in which a CT scan performed after a retrograde urethrogram ... | ['Adult', 'Catheterization', 'Emergency Medicine', 'Hematoma', 'Humans', 'Inguinal Canal', 'Male', 'Rupture', 'Tomography, X-Ray Computed', 'Urethra', 'Urinary Bladder Diseases', 'Urology'] | 15,028,330 | [['M01.060.116'], ['E02.148', 'E05.157'], ['H02.403.250'], ['C23.550.414.838'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A01.923.047.412'], ['C26.761'], ['E01.370.350.350.810', 'E01.370.350.600.350.700.810', 'E01.370.350.700.700.810', 'E01.370.350.700.810.810', 'E01.370.350.825.810.810'], ['A05.360.444.492.72... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Effects of Therapy in Patients Suffering from Chronic Back Pain Treated with Spinal Cord Stimulation. | Pain in the lumbosacral part of the spine in the course of degenerative disease is the most common cause of physical activity limitation in adults. Treatment includes pharmacotherapy, physiotherapy, psychotherapy, health promotion, and sometimes surgery. Surgical treatment is not always successful, and the various clin... | ['Adult', 'Aged', 'Aged, 80 and over', 'Chronic Pain', 'Cohort Studies', 'Failed Back Surgery Syndrome', 'Female', 'Humans', 'Low Back Pain', 'Male', 'Middle Aged', 'Neuralgia', 'Pain Measurement', 'Spinal Cord Stimulation', 'Treatment Outcome'] | 26,187,548 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C23.888.592.612.274'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['C23.550.767.225', 'C23.888.592.612.107.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.888.592.612.107.400'], ['M01.060.116.630'], ['C10... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Motivation to change as a mediator for the longitudinal relationships of gender and alcohol severity with one-year drinking outcome. | OBJECTIVE: We examined whether motivation to change mediated the relationships between gender and baseline alcohol severity with drinking outcome at 12-month follow-up in a longitudinal community sample.METHOD: Data were from baseline and 12-month interviews from the Rural Alcohol Study, a probability sample of rural a... | ['Adult', 'Alcohol Drinking', 'Alcohol-Related Disorders', 'Data Collection', 'Female', 'Follow-Up Studies', 'Humans', 'Longitudinal Studies', 'Male', 'Motivation', 'Rural Population', 'Sex Factors', 'Time Factors', 'United States', 'Urban Population'] | 22,456,256 | [['M01.060.116'], ['F01.145.317.269'], ['C25.775.100', 'F03.900.100'], ['E05.318.308', 'L01.399.250', 'N05.715.360.300', 'N06.850.520.308'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.500.750.500', 'N05.715.36... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
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